WorldWideScience

Sample records for laurence kell hans

  1. ENTREVISTA CON LAURENCE VIENNOT

    Directory of Open Access Journals (Sweden)

    CAROLINA MARIN

    2010-12-01

    Full Text Available Interview with Laurence Viennot. Brief Biography: Laurence Viennot, born in France. She conducted research in the astrophysics field, in Paris, from 1970 until 1975. In 1977, she obtained her PhD in physics education at the University Denis Diderot, Paris VII. In this University she founded and directed the master's program in Science Education, and, worked alternately as a professor in the Department of Physics. She researched and wrote important works about common knowledge and reasoning ways in learning physics.Questions for Professor Viennot: 1. What are you doing currently in physics teaching research?. 2. What is your opinion about the emerging of science education research, and inside it, the physics didactic as an autonomous field of research? 3. What do you consider is the most important knowledge to teach to future physics teachers? 4. How do you suggest to include issues of modern physics in physics education,at the secondary level? 5. Why there is a need research on natural reasoning in physics? 6. What that’s mean “common reasoning” in physics? 7. Can you talk us about physics texts that, usually have the laws, concepts and physical phenomena in a very "simplistic" or general? 8. How influential can become textbooks on reasoning ways in physics learning? 9. What is the teacher's role in the analysis of such texts? 10. You said that in France the content and teaching texts evolved, how did this change? What was the proposal to publishers? 11. How to contribute to systemic analysis beyond the ritual practices? 12. What factors should be taken into account to contribute in improvement of teaching and learning processes in physics class? 13. What do you think about Colombia, and your experience in this academic event?

  2. Kell immunization: A case report

    OpenAIRE

    Tasić Marija; Milošević Jelena; Stefanović Milan; Radović-Janošević Dragana; Krstić Miljan; Antić Vladimir

    2009-01-01

    Introduction. The frequency of occurrence of RhD alloimmunization, due to preventive protocols, is decreased in our country, but more often there are other antigens that emerge as a cause of hemolytic disease of fetus. The most prominent is Kell antigen, which promotes specific course of disease based on an innate pathogenetic mechanism. Anti- Kell antibody production is, just as in other atypical antibodies, provoked with transfusion of incompatible blood. Except for the immune-mediated hemo...

  3. Research Ship Laurence M. Gould Underway Meteorological Data, Quality Controlled

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Research Ship Laurence M. Gould Underway Meteorological Data (delayed ~10 days for quality control) are from the Shipboard Automated Meteorological and Oceanographic...

  4. Isolation of a Kell-reactive protein from red cell membranes.

    Science.gov (United States)

    Wallas, C; Simon, R; Sharpe, M A; Byler, C

    1986-01-01

    A red cell membrane protein which exhibits Kell blood group antigen activity has been identified with a purified anti-Kell bound to a Protein-A agarose column and eluting with lithium diiodosalicylate (LIS). Although anti-Kell as well as the Kell-reactive membrane protein were eluted from the column, the eluate was capable of reducing the titer of added anti-Kell from 64 to 4. In addition, the eluate was shown to possess Kell reactivity by binding I125 Protein A after incubation with anti-Kell. Electrophoresis (SDS gel polyacrylamide 5-20% gradient) showed a band at approximately 90,000 daltons when solubilized membranes from Kell-positive red cells were used but not when membranes from dithiothreitol- and papain-treated Kell-positive red cells or Kell-negative red cells were used. A band isolated with unreduced conditions was capable of neutralizing anti-Kell.

  5. Investigation of monoclonal antibodies directed against Fy3, Jra, Lub, Kell or Kell related antigens.

    Science.gov (United States)

    Janvier, D; Veaux, S; Benbunan, M

    1997-01-01

    Twenty Mabs of human or murine origin were studied. Serological characterization was achieved by the gel technique with common, rare, and enzyme-modified RBCs. Three clones bound to cell surface proteins on immunoblots: 1 anti-Lub and 2 Mabs raised to a purified Kell glycoprotein. Four anti-K Mabs precipitated the expected 93kD protein and a dimeric form under non-reducing conditions.

  6. Homme kell 11 algab Pärnu uue kunsti muuseumis...

    Index Scriptorium Estoniae

    2005-01-01

    Mati Põldre ja Mark Soosaare filmi- ja fotokunsti meistriklass ning kell 12 Leo Rohlini loeng "Pilk eesti keraamikale". Loengut illustreerivad slaidiprogramm, Urmas Puhkani tehtud Leo Rohlini personaalnäituse video ja Tõnu Aru film keraamik Evi Mardnast

  7. Recalcitrant psoriasis vulgaris associated with Laurence-Moon-Biedl syndrome.

    Science.gov (United States)

    Margolin, L; Haliulin, Y

    2003-09-01

    We report a 30-year-old European (Ashkenazi Jewish) male with Laurence-Moon-Biedl syndrome (Bardet-Biedl type) who was hospitalized because of severe recalcitrant plaque-type psoriasis. Laurence-Moon-Biedl syndrome has been shown to be linked to the chromosome 11q region in the majority of the patients of European descent. The same 11q region had increased frequency of aberrations in the study that included cytogenetic analysis of 477 psoriatic patients. The animal model of the syndrome (mice) showed abnormalities in hair growth and epidermal differentiation. This genetic association between Laurence-Moon-Biedl syndrome and psoriasis can contribute to the understanding of the factors involved in the initiation of psoriasis and factors that modulate its severity and resistance to therapy.

  8. A Literature Unit for "Dragon's Gate" by Laurence Yep.

    Science.gov (United States)

    Thomas-Vallens, Mary

    Intended as a an aid to classroom teachers, this 52-page handbook presents a literature unit based on the children and young people's book, "Dragon's Gate" by Laurence Yep. It begins with sample lesson plans, pre-reading activities, author information, a book summary, vocabulary lists and suggested vocabulary activities. Next, chapters…

  9. A Literature Unit for "Dragon's Gate" by Laurence Yep.

    Science.gov (United States)

    Thomas-Vallens, Mary

    Intended as a an aid to classroom teachers, this 52-page handbook presents a literature unit based on the children and young people's book, "Dragon's Gate" by Laurence Yep. It begins with sample lesson plans, pre-reading activities, author information, a book summary, vocabulary lists and suggested vocabulary activities. Next, chapters…

  10. $K_{\\ell3}$ decays in Chiral Perturbation Theory

    CERN Document Server

    Bijnens, J; Bijnens, Johan; Talavera, Pere

    2003-01-01

    The process $K_{\\ell3}$ is calculated to two-loop order ($p^6$) in Chiral Perturbation Theory (ChPT) in the isospin conserved case. We use expressions suitable for use with previous work in two-loop CHPT where the order $p^4$ parameters ($L_i^r$) were determined from experiment. We point out that all the order $p^6$ parameters ($C_i^r$) that appear in the value of $f_+(0)$ relevant for the determination of $|V_{us}|$ can be determined from $K_{\\ell3}$ measurements via the slope and the curvature of the scalar form-factor.

  11. Kelle pension vajab enim tõstmist? / Taavi Rõivas

    Index Scriptorium Estoniae

    Rõivas, Taavi, 1979-

    2007-01-01

    Riigikogu liikme sõnul näeb Reformierakond vajadust tõsta eeskätt praeguste vanemate pensionäride pensioni, Keskerakonna esitatud pensioniseaduse muudatus aga viiks praegu töötavate inimeste tulevikupensioni tõusule. Ta selgitab pensioni kujunemist ning kutsub inimesi oma arvamust avaldama, kelle pension peaks praegu olema esikohal

  12. Incidence of Kell blood group in Kashmiri population attending blood bank SKIMS as donors

    Directory of Open Access Journals (Sweden)

    Mohd Younus Shah

    2013-01-01

    Full Text Available Purpose: To determine anti-Kell in Kashmiri population. Material and Methods: Prospective study of One Year. Result: Six patients were tested positive. Conclusion: The incidence of Kell is very low i.e., 0.03% and correlates to the incidence of Japanese.

  13. An irresponsible biography of the actor Laurence Harvey: motion pictures, white wine, older women & long thin cigarettes

    OpenAIRE

    Brannon, Matthew

    2015-01-01

    Tiré du site Internet de Onestar Press: "Pocket edition of Laurence Harvey's "irresponsible" biography by Matthew Brannon. From the back cover of the book : Call yourself an actor ? You're not even a bad actor. You can't act at all, you fucking stupid hopeless sniveling little cunt-faced cunty fucking shit-faced arse-hole ... LAURENCE OLIVIER to Laurence Havery from Robert Stephen's "Knight errant : memoirs of a vagabond actor", Hodder and Stoughton, 1995.".

  14. Estimating the recombination frequency for the PTC-Kell linkage.

    Science.gov (United States)

    Anne-Spence, M; Falk, C T; Neiswanger, K; Field, L L; Marazita, M L; Allen, F H; Siervogel, R M; Roche, A F; Crandall, B F; Sparkes, R S

    1984-01-01

    Two data sets are analyzed for linkage between the PTC and Kell blood group loci. The original report of close linkage for these loci was that of Conneally et al. (1976), where the maximum likelihood estimate of theta was 0.05. These two new data sets give a combined maximum likelihood estimate of theta m = f = 0.28. Estimating the recombination frequency for the sexes separately gave theta m = 0.29, theta f = 0.23. The combined maximum likelihood estimate over all published data sets including this report is theta m = f = 0.14, Zmax = 8.94. There is statistically significant evidence of heterogeneity among the published studies.

  15. Lapi torn, Ameerika kotkas ja gooti kell / Vilen Künnapu ; intervjueerinud Margit Mutso

    Index Scriptorium Estoniae

    Künnapu, Vilen, 1948-

    2010-01-01

    Arhitekt Vilen Künnapu oma installatsioonist "Gooti kell", mis avati 2. novembril Lilleoru pargis, arhitekti rollist, osalemisest koos Ain Padriku, Lennart Meri ja Andres Siimuga rahvusvahelistel arhitektuurivõistlustel, valminud hoonetest, installatsioonidest, praegusest tegevusest jm.

  16. Clinical Significance of an Alloantibody against the Kell Blood Group Glycoprotein

    Science.gov (United States)

    Mattaloni, Stella Maris; Arnoni, Carine; Céspedes, Rosario; Nonaka, Claudia; Trucco Boggione, Carolina; Luján Brajovich, Melina Eliana; Trejo, Andrea; Zani, Néstor; Biondi, Claudia Silvia; Castilho, Lilian; Cotorruelo, Carlos Miquel

    2017-01-01

    Background Kell null (K0) individuals can produce anti-Ku, an antibody against many epitopes in the Kell glycoprotein, after transfusion and/or pregnancy. Since sensitized K0 patients are rare, little is known about anti-Ku clinical relevance and in particular about its association to hemolytic disease of the fetus and newborn. Case Report This work describes a case of neonatal hyperbilirubinemia due to immune-mediated erythrocyte destruction by an alloantibody directed against the Kell glycoprotein. Serologic and molecular approaches identified an anti-Ku alloantibody in maternal serum. A homozygous IVS3 + 1g>a point mutation (KEL*02N.06 allele) was found to be responsible for the lack of Kell antigen expression in the mother's red blood cell and subsequent alloimmunization after a previous pregnancy. Even though in most cases Kell antibodies are clinically severe and may cause suppression of erythropoiesis, in our case the newborn had a moderate anemia and hyperbilirubinemia that was successfully treated with phototherapy without requiring exchange transfusion. Serological and molecular studies performed in the proband's family members allowed us to provide them with proper counseling regarding alloimmunization after transfusion and/or pregnancy. Conclusions This case enlarges the understanding of the clinical significance of alloantibodies against Kell blood group antigens.

  17. A case of Hydrops fetalis due to Kell alloimmunization: A perinatal approach to a rare case

    Directory of Open Access Journals (Sweden)

    Arzu Akdag

    2012-03-01

    Full Text Available Introduction: While the routine administration of Rhesus immunoglobulin has significantly reduced the incidence of this type of alloimmunization, maternal alloimmunization to other red cell antigens continues to contribute to perinatal morbidity and mortality. Although the Kell antigen is found on the red cells of only 9% of the population, attention has increasingly been focused on Kell antibodies. Case Report: We present a case of fetal hydrops who was sonographically detected at 30th week of pregnancy. Antenatal tests for evaluation of fetal condition clearly showed the critical level of hemolytic disease but the baby was delivered prematurely due to fetal distress. The combination of anemia, reticulocytopenia, hydrops fetalis, and positive indirect Coombs test suggested Kell isoimmunization. The baby was treated by exchange transfusion with the Kell-negative packed red cell succesfully, and was discharged on postnatal 30th day. Conclusion: Here we describe a case of hydrops fetalis caused by Kell alloimmunization that was determined in postnatal period, and thus we plan to discuss the perinatal approach to the Kell immunization.

  18. Review - Critical Han Studies

    Directory of Open Access Journals (Sweden)

    Zhiguo Ye

    2013-12-01

    Full Text Available Review of: Thomas Mullaney, James Leibold, Stéphane Gros, and Eric Armand Vanden Bussche (eds. 2012. Critical Han Studies: The History, Representation, and Identity of China's Majority. Berkeley, Calif: University of California Press. This path-breaking volume is an academic collaboration that emerged out of the "Critical Han Studies Conference and Workshop" at Stanford University in April 2008. Eleven scholars contributed to the question of what it means to be 'Han' in China, both historically and at present. Constituting over ninety percent of China's population, the Han are not only the largest ethnic group in China, but are also one of the largest categories of collective identity in the world. Despite this, the dominant Han group has so far eluded careful scholarly scrutiny, with the Han often referred to as an unmarked majority category in contemporary China. This volume challenges such conventional views by conceptualizing new interdisciplinary approaches to the question of Hanness. The eleven essays of the volume are divided into three themes: 'Han and China', 'The Problem of Han Origins', and 'The Problem of Han Formations'. The first theme, comprised of four essays, analyzes the ties that bind the category of Han to those of Chinese ethnicity, race, and polity. Kevin Carrico in "Recentering China: The Cantonese in and Beyond the Han" questions a single, unitary Hanness that he believes conceals "countless other perceived and imagined lines of differentiation" (25. The study examines how multiple identities...

  19. Laurence W. Mazzeno. Becoming John Updike: Critical Reception, 1958-2010

    OpenAIRE

    2013-01-01

    John Updike scholarship seems to be thriving. After The John Updike Encyclopedia by Jack De Bellis (2000) another volume of encyclopedic nature has come out this year: Becoming John Updike: Critical Reception, 1958-2010 by Laurence W. Mazzeno, President Emeritus of Alvenia University, whose volumes on Austen, Dickens, Tennyson and Matthew Arnold make his latest one a classic. As its title indicates, the book presents critical reception that covers both journalistic and academic responses to U...

  20. Building Communities in Resistance, Metelkova City in the Hands of Axt und Kelle

    Directory of Open Access Journals (Sweden)

    Sandi Abram

    2013-09-01

    Full Text Available The article deals with nomadic journeymen and journeywomen from the German guild Axt und Kelle and with their encounter with Metelkova. At the outset, the historical trajectory of German guilds, the constitution of Axt und Kelle and the custom of tramping artisans (i.e., walz are highlighted. The hypothesis that Axt und Kelle make use of re-appropriated spaces (i.e., squats either as a sporadic proactive clientele or they choose such spaces as their annual summer solidarity work camps is defended on a twofold basis: firstly, squats are considered and constructed as a substitute of the previously guaranteed houses of call (i.e., herberge by the classical guilds. Secondly, the guild intentionally constituted itself as a political subject with the mission of empowering communities in resistance. ACC Metelkova City was chosen as a solidarity work camp twice in the early and mid-00s when many emblematic interiors and exteriors were created. Focusing on the non-instrumentalized (own production of knowledge, exchange of experiences and outwardly oriented distribution, the article views the reciprocal interaction between ACC Metelkova City and Axt und Kelle through Mauss’s theory of the gift.

  1. Anti-K1 (Kell) Antibody Expressed in Maternal Breastmilk: A Case Report of a Neonate with Multiple Intrauterine Transfusions and Postnatal Exposure to Kell Antibody in Maternal Breastmilk

    Science.gov (United States)

    Asfour, Mohamed; Hersey, Kelly

    2017-01-01

    Hemolytic disease of the fetus and newborn is a common consideration in newborn medicine, especially among the jaundiced. Maternal breastmilk provides numerous benefits to the infant, including nutrition and immunologic factors. Here, we present an infant who received three intrauterine transfusions for anemia secondary to anti-K1 (Kell), anti-C, and anti-e antibodies and whose maternal breastmilk tested positive for anti-Kell antibodies. The infant required another transfusion at 4 weeks of life for anemia. We review the pathophysiology of anti-Kell antibodies, the immunology of breast milk, and the intersection of these two topics. PMID:28357148

  2. Hans Christian Jacobaeus: Inventor of human laparoscopy and thoracoscopy.

    Science.gov (United States)

    Hatzinger, Martin; Kwon, S T; Langbein, S; Kamp, S; Häcker, Axel; Alken, Peter

    2006-11-01

    Hans Christian Jacobaeus performed the first clinical laparoscopic surgery in Stockholm. This pioneering procedure was based on the animal experiments of Georg Kelling (1866-1945), a German physician from Dresden, who performed the first laparoscopic intervention in 1901 using a Nitz cystoscope in a dog. In 1910, Jacobaeus published his initial experiences with laparoscopic surgery in the Münchner Medizinischen Wochenschrift under the title "The Possibilities for Performing Cystoscopy in Examinations of Serous Cavities." He used this technique for diagnostic purposes in undefined abdominal complaints and functional impairment. Jacobaeus was the first who pointed out the possibility of injuring organs, especially the intestines, by inserting the trocar. In 1910, Jacobaeus recognized the immense diagnostic and therapeutic possibilities of laparoscopic surgery, as well as its difficulties and limits. He also was the first to realize the need for initial endoscopic training in animals and corpses. He promoted the development of special laparoscopic instruments to optimize and simplify the procedure.

  3. Han er her endnu

    DEFF Research Database (Denmark)

    Bonde, Lisbeth

    2012-01-01

    Interview med den kinesiske aktivist og billedkunstner Ai Weiwei, der sad fængslet i 81 dage i 2011. Hans pas er stadig (i februar 2014) inddraget af myndighederne, så han kan ikke forlade landet, selv om han har betalt en bøde på 13 mio. kr. for ”skatteunddragelse”. Både i sin kunst og i sine...

  4. A very large soul: selected letters from Margaret Laurence to Canadian writers A very large soul: selected letters from Margaret Laurence to Canadian writers

    Directory of Open Access Journals (Sweden)

    John J. O'Connor

    2008-04-01

    Full Text Available “This will be a brief letter, as I have a horrifying stack of business letters to catch up on,” wrote Margaret Laurence to her friend and fellow novelist Gabrielle Roy in 1978, echoing an earlier lament to her epistolary friend Ernest Buckler about the need to “keep pace with the ghastly flow of business correspondence.” Although she was always to face some tension between her personal and professional selves as correspondent, her priority was never in question: “Must go. I have 70 letters to reply to, having got far behind in correspondence ... am trying now to communicate once again with dear friends first, and then to answer all the others, which will no doubt be my winter project” (4 Sept. 1974 letter to Silver Donald Cameron. “This will be a brief letter, as I have a horrifying stack of business letters to catch up on,” wrote Margaret Laurence to her friend and fellow novelist Gabrielle Roy in 1978, echoing an earlier lament to her epistolary friend Ernest Buckler about the need to “keep pace with the ghastly flow of business correspondence.” Although she was always to face some tension between her personal and professional selves as correspondent, her priority was never in question: “Must go. I have 70 letters to reply to, having got far behind in correspondence ... am trying now to communicate once again with dear friends first, and then to answer all the others, which will no doubt be my winter project” (4 Sept. 1974 letter to Silver Donald Cameron.

  5. Virginia Woolf’s learning to hybridize: Laurence Sterne's sneer at generic boundaries

    Directory of Open Access Journals (Sweden)

    Paolo Bugliani

    2016-11-01

    Full Text Available The paper aims at assessing the treatment that Virginia Woolf the critic reserved to Laurence Sterne, and at highlighting the main sites in Woolf’s ‘Poetics’ where the influence of the Augustan humorist was strongest, i.e. the delicate relation between Life and Literature, and the idea of a Poetry that transcends the limits of verse to encompass prose and prosaic expressions. In order to demonstrate this fruitful filiation, the essays where Woolf dealt directly with Sterne have been analyzed in parallel with other critical pronouncements and/or journal entries where the author developed the metaliterary hints that Sterne’s example roused.

  6. Evelin Ilves asus Šveitsi suurfirma ausaadikuks. Meeleheaks 52 000 krooni maksev kell / Katrin Rohtla

    Index Scriptorium Estoniae

    Rohtla, Katrin, 1966-

    2008-01-01

    17. mail 2008 oli Estonia teatris "Tristani ja Isolde" esietendus, kus proua Evelin Ilves nimetati Šveitsi luksuskellade meistri Raymond Weili ausaadikuks. Tiitliga kaasnes kingitusena teemantidega käekell. Kommenteerivad Aktsiaseltsi Balti Kell juhataja Toivo Aalja ja proua E. Ilvese erasekretär Piia Vann. Vt. samas: Kadri Simson: ausaadik on peen nimetus reklaamnäole. Riigikogu korruptsioonivastase seaduse kohaldamise erikomisjoni liikme Kadri Simsoni kommentaar. Vt. ka juhtkiri lk. 8: Reklaampost. SL Õhtulehe arvates on sobimatu, et presidendiproua seotakse ühe äriettevõtte huvidega

  7. Evelin Ilves asus Šveitsi suurfirma ausaadikuks. Meeleheaks 52 000 krooni maksev kell / Katrin Rohtla

    Index Scriptorium Estoniae

    Rohtla, Katrin, 1966-

    2008-01-01

    17. mail 2008 oli Estonia teatris "Tristani ja Isolde" esietendus, kus proua Evelin Ilves nimetati Šveitsi luksuskellade meistri Raymond Weili ausaadikuks. Tiitliga kaasnes kingitusena teemantidega käekell. Kommenteerivad Aktsiaseltsi Balti Kell juhataja Toivo Aalja ja proua E. Ilvese erasekretär Piia Vann. Vt. samas: Kadri Simson: ausaadik on peen nimetus reklaamnäole. Riigikogu korruptsioonivastase seaduse kohaldamise erikomisjoni liikme Kadri Simsoni kommentaar. Vt. ka juhtkiri lk. 8: Reklaampost. SL Õhtulehe arvates on sobimatu, et presidendiproua seotakse ühe äriettevõtte huvidega

  8. Ictericia e incompatibilidad por grupo Kell: caso clínico.

    OpenAIRE

    2010-01-01

    Dentro de las patologías más frecuentes que afectan al recién nacido se encuentra la ictericia. Sus etiologías son diversas y conforman una larga lista que varía desde causas infecciosas, metabólicas, hematológicas, inmunológicas, entre otras. Sin embargo, cuando se presenta durante las primeras horas, las causas más frecuentes corresponden a incompatibilidades de grupo sanguíneo y de ellas, la incompatibilidad Rh y ABO suelen ser más frecuentes. La incompatibilidad por grupo Kell, en cambio...

  9. Laurence-Moon-Biedl综合征伴慢性肾脏病1例

    Institute of Scientific and Technical Information of China (English)

    张以勤; 颜建华; 陈明革

    2008-01-01

    我院收治1例Laurence-Moon-Biedl综合征病例,男性,16岁,出生时即多指(趾)畸形,高度近视,食欲大,体型肥胖,智力水平较同龄儿童差,经多项检查确诊.本病分五型:完全型、不完全型、顿挫型、非典型型、扩大进展型,诊断中应注意与Astrom综合征、Froehtich综合征、Klinefetter综合征、Prader-willi综合征、皮质醇增多症等相鉴别,无特效治疗方法.死因主要有肾脏疾病和心血管疾病等.

  10. Hans Grauert: Mathematician Pur

    CERN Document Server

    Huckleberry, Alan

    2010-01-01

    This article was written on the occasion of Hans Grauert receiving the Cantor Medallion of the Deutsche Mathematische Vereinigung. It is a brief overview of his mathematical contributions and attempts to convey the author's great respect for the man and his science.

  11. Hans Christian Andersen

    DEFF Research Database (Denmark)

    Nørgaard, Jørgen

    2007-01-01

    The Danish author, Hans Christian Andersen, living in the 1800s expressed through his fairy tales and other stories an enthusiasm for the technological breakthroughs in that century with trains, etc. But he also showed great concern for what the natural science did to people by narrowing their mind...

  12. Special issue: Hans Bethe

    CERN Multimedia

    Gottfried, Kurt

    2005-01-01

    "There are a handful of people who soar, whose accompalishments are so off-scale as to nearly defy belief. Hans Bethe (2 July 1906 - 6 March 2005) was of that caliber. As just one measure of his stature, imagine the task of copying his published opus by hand, for that is how he wrote most of it" (2 pages)

  13. Ictericia e incompatibilidad por grupo Kell: caso clínico.

    Directory of Open Access Journals (Sweden)

    Miguel Zúñiga

    2010-08-01

    Full Text Available Dentro de las patologías más frecuentes que afectan al recién nacido se encuentra la ictericia. Sus etiologías son diversas y conforman una larga lista que varía desde causas infecciosas, metabólicas, hematológicas, inmunológicas, entre otras. Sin embargo, cuando se presenta durante las primeras horas, las causas más frecuentes corresponden a incompatibilidades de grupo sanguíneo y de ellas, la incompatibilidad Rh y ABO suelen ser más frecuentes. La incompatibilidad por grupo Kell, en cambio, es un trastorno mucho menos frecuente. Se presenta en un recién nacido con ictericia secundaria a una anemia hemolítica y que posee anticuerpos relacionados con el grupo sanguíneo Kell. Su evolución puede ser compleja y severa, requiriendo en algunos casos manejo en cuidados intensivos y apoyo importante de hemoderivados. Todo lo anterior hace importante conocer esta patología, de manera de poder identificarla y actuar a tiempo en su tratamiento.

  14. Ictericia e incompatibilidad por grupo Kell: caso clínico.

    Directory of Open Access Journals (Sweden)

    Miguel Zúñiga

    2009-01-01

    Full Text Available Dentro de las patologías más frecuentes que afectan al recién nacido se encuentra la ictericia. Sus etiologías son diversas y conforman una larga lista que varía desde causas infecciosas, metabólicas, hematológicas, inmunológicas, entre otras. Sin embargo, cuando se presenta durante las primeras horas, las causas más frecuentes corresponden a incompatibilidades de grupo sanguíneo y de ellas, la incompatibilidad Rh y ABO suelen ser más frecuentes. La incompatibilidad por grupo Kell, en cambio, es un trastorno mucho menos frecuente. Se presenta en un recién nacido con ictericia secundaria a una anemia hemolítica y que posee anticuerpos relacionados con el grupo sanguíneo Kell. Su evolución puede ser compleja y severa, requiriendo en algunos casos manejo en cuidados intensivos y apoyo importante de hemoderivados. Todo lo anterior hace importante conocer esta patología, de manera de poder identificarla y actuar a tiempo en su tratamiento.

  15. The Hans Tausen drill

    DEFF Research Database (Denmark)

    Johnsen, Sigfus Johann; Dahl-Jensen, Dorthe; Steffensen, Jørgen Peder

    2007-01-01

    In the mid-1990s, excellent results from the GRIP and GISP2 deep drilling projects in Greenland opened up funding for continued ice-coring efforts in Antarctica (EPICA) and Greenland (NorthGRIP). The Glaciology Group of the Niels Bohr Institute, University of Copenhagen, was assigned the task...... of providing drilling capability for these projects, as it had done for the GRIP project. The group decided to further simplify existing deep drill designs for better reliability and ease of handling. The drill design decided upon was successfully tested on Hans Tausen Ice Cap, Peary Land, Greenland, in 1995....... The 5.0 m long Hans Tausen (HT) drill was a prototype for the ~11 m long EPICA and NorthGRIP versions of the drill which were mechanically identical to the HT drill except for a much longer core barrel and chips chamber. These drills could deliver up to 4 m long ice cores after some design improvements...

  16. Hans Bethe's early life

    Science.gov (United States)

    Bernstein, Jeremy

    2012-10-01

    In 1937, two years after he moved to the US to escape Nazi persecution, the physicist Hans Bethe sent a letter to his mother in Germany. In it, he wrote, "I think I am about the leading theoretician in America. [Eugene] Wigner is certainly better and [Robert] Oppenheimer and [Edward] Teller probably just as good. But I do more and talk more and that counts too."

  17. Tribute to Hans Sann

    CERN Multimedia

    2003-01-01

    1945-2003 Hans Sann, an internationally recognized scientist, beloved colleague and friend, died in a tragic car accident, on May 27th, on one of his many travels to CERN. Employed at GSI, in Darmstadt, since 1979, Hans Sann devoted most of his scientific career to the development of large size gas detectors for nuclear and high-energy physics experiments at GSI, CERN and Berkeley. One of his main achievements, among many others, was the famous MUSIC detector, on which several projects at GSI, Berkeley and other research Institutes were based. The innovative results obtained in the study of the fluid-gas transition in nuclear matter would not have been possible without his contribution and the application of the MUSIC detector. A member of the ALICE Collaboration since 1996, Hans was leading two main ALICE sub-programmes, the development of the gas system and the cooling system for the TPC detector. In addition, he was involved in the development of a new technological concept for the resistor chain of the ...

  18. Genotyping of Kell, Duffy, Kidd and RHD in patients with b Thalassemia

    Directory of Open Access Journals (Sweden)

    Castilho Lilian

    2000-01-01

    Full Text Available Determination of Rh, Kell, Duffy and Kidd phenotypes in addition to ABO is used to prevent the alloimmunization to red blood cells (RBCs antigens and as part of the antibody identification process in patients with beta Thalassemia. However, phenotyping in these patients can be time consuming and difficult to interpret. In these situations, it would be valuable to have an alternative to hemagglutination tests to determine the patient's antigen profile. We used PCR-RFLP to genotype such patients. DNA was prepared from 50 patients with beta Thalassemia who had been phenotyped by routine hemagglutination, and tested for Kell, Kidd, Duffy/GATA mutation by PCR-RFLP. RHD/non-D was analysed by PCR product size associated to RHD gene sequence in intron 4 and exon 10/3'UTR. The genotyping assays were performed without knowledge of phenotype results. For RHD/non-D, 47 were RhD+ and RHD+/RHCE+, and 3 were RhD- and RHD-/RHCE+. For Kell, 48 kk were K2K2 and 2 Kk were K1K2. For Duffy, of 44 samples that had normal GATA box, 8 Fy(a+b- were FYA/FYA, 15 Fy(a+b+ were FYB/FYB, and 19 Fy(a+b+ were FYA/FYB; of the other 4 samples 3 were FYA/FYB and heterozygous GATA mutation, and 1 Fy(a-b- was FYB/FYB, homozygous GATA mutation. Two samples phenotyped as Fy(a+b- that had normal GATA , presented the 265T/298A mutations and two samples phenotyped as Fy(a-b+ were genotyped was FYA/FYB.. For Kidd , 15 Jk(a+b were JKA/JKA, 12 Jk(a-b+ were JKB/JKB, and 20 Jk(a+b+ were JKA/JKB. Three samples phenotyped as JK(a+b+ were genotyped as JKB/JKB. Genotype is more accurate than phenotype for determination of blood groups in polytransfused patients with betaThalassemia. Genotyping in these patients can be helpful to select antigen-negative RBCs for transfusion.

  19. Han digtede om det uudsigelige

    DEFF Research Database (Denmark)

    svendsen, erik

    2015-01-01

    Paul Celan skrev det vigtigste litterære vidnesbyrd om holocaust, inden han druknede sig i Seinen. Ny samling af hans uafrystelige og virtuost forfærdende poesi på dansk.......Paul Celan skrev det vigtigste litterære vidnesbyrd om holocaust, inden han druknede sig i Seinen. Ny samling af hans uafrystelige og virtuost forfærdende poesi på dansk....

  20. Singer Han Hong

    Institute of Scientific and Technical Information of China (English)

    KIRIN; KID

    2000-01-01

    HAN Hong had a happy childhood in the beautiful Xigaze City, Tibet. From the children's chorus, the military art troupe, the Prize Winning Competition on TV, up to the institute of art, she has never stopped singing. The difference to other singers her age is that she not only wishes to be a singer but a composer. Not satisfied with just singing the songs of others, she began expressing her happiness and sadness by writing her own. Finally she finished her first collection Rays in Tibet, which is the fi...

  1. Plant regeneration via somatic embryogenesis from protoplast of Clausena harmandiana (Engl. Swing and M. Kell

    Directory of Open Access Journals (Sweden)

    Hasan Basri JUMIN

    2013-05-01

    Full Text Available Protoplasts isolated from embryogenic callus of Clausena harmandiana (Engl. 'Swing. and M. Kell. were cultured in MT (Murashige and Tucker 1969 basal medium containing 5% sucrose supplemented with bezyladenine (BA, malt extract (ME and 0.6 M sorbitol. The highest plating efficiency was obtained on MT basal medium containing 5% sucrose supplemented with 0.01 mg 1-1 BA and 600 mg 1-1 ME, MT basal medium containing 5% sucrose and supplemented with 0.01 mg 1-1 6(-y,y-dimethylallylamino-purine was found to be a medium suitable for the development somatic embryos into heart-shaped somatic embryos. The highest percentage of shoot formation- was obtained using 0.1 mg 1-1 gibberellic acid (GA3 + 0.1 mg 1-1 zeatin. In this investigation 25 plants were survived and grew normally in the soil.

  2. Interview Hans Blix

    CERN Multimedia

    2013-01-01

    The Thorium Energy Conference, ThEC13, ran from 27 to 31 October at CERN, addressing the scientific and technical advances offered by thorium – a silvery white metal four times more abundant than uranium in the Earth's crust – in alternative nuclear technologies for energy production and for the destruction of nuclear waste. Conference Chair Egil Lillestol invited Swedish diplomat and politician Hans Blix to talk about "Thorium Nuclear Power and Non-Proliferation". In a career spanning more than 50 years, Blix has been head of the International Atomic Energy Agency and the United Nations Monitoring, Verification and Inspection Commission. During the 1990s, CERN has been pioneering thorium technologies research with experiments instigated by Nobel laureate Carlo Rubbia, testing the basic concepts of a thorium-fuelled reactor driven by a proton accelerator.

  3. Frequencies of polymorphisms of the Rh, Kell, Kidd, Duffy and Diego systems of Santa Catarina, Southern Brazil

    Directory of Open Access Journals (Sweden)

    Daiane Cobianchi Costa

    Full Text Available ABSTRACT BACKGROUND: Red blood cell genes are highly polymorphic with the distribution of alleles varying between different populations and ethnic groups. The objective of this study was to investigate gene polymorphisms of blood groups in the state of Santa Catarina, Southern Brazil. METHODS: Three hundred and seventy-three unrelated blood donors and 31 transfusion-dependent patients were evaluated to investigate polymorphisms of the Rh, Kell, Duffy, Kidd, and Diego blood group systems in a population from the state of Santa Catarina. The subjects, from seven regions that comprise the blood-banking network of the state, were assessed between August 2011 and March 2014. The genotypes of the Rh, Kell, Duffy, Kidd, and Diego systems were determined using the restriction fragment length polymorphism-polymerase chain reaction and allele-specific polymerase chain reaction techniques. RESULTS: The genotype frequencies in this study were significantly different when populations from different regions of Santa Catarina were compared. Furthermore, there were also significant differences in the genetic frequencies compared to other Brazilian states. The genotype frequencies of the Kell and Kidd blood groups are similar to European populations from Naples, Italy and Zurich, Switzerland. CONCLUSION: This article reports for the first time the frequency of polymorphisms of blood group systems in blood donors from Santa Catarina, Southern Brazil.

  4. 'At Variance With Both General and Expert Opinion': The Later Works of Lieutenant-Colonel Professor Laurence Austine Waddell

    Directory of Open Access Journals (Sweden)

    Gabriel Moshenska

    2010-05-01

    Full Text Available An intellectual history can trace the movement of an idea into, and out of, the academic mainstreams of its time. Less often, it might turn its gaze on ideas that never gained widespread acceptance but remained and remain esoteric. Such marginal works are of value to historians in so far as they allow us to tentatively trace the margins of a past intellectual community. Few scholars can have inhabited these margins, and built more spectacular intellectual edifices there, than Lieutenant-Colonel Professor Laurence Austine Waddell.

  5. Local food between nature and culture: from neighbour farm to terroir. Interview of Laurence Bérard

    Directory of Open Access Journals (Sweden)

    Isabelle Techoueyres

    2005-05-01

    Full Text Available V.A.: Laurence Bérard, you stand for one half of the famous Bérard and Marchenay duo whose works on terroir products in France simply cannot be ignored ; this is the reason why you accepted this interview for our AOF issue on local food products. I’ll just start with the plain question: when I say local products, what do you think of? L.B.: you’re not saying terroir products, for a change…I.T: That’s the point, is there a difference between the French expression terroir products and local pro...

  6. The afterlife of Laurence Sterne (1713-1768): Body snatching, dissection and the role of Cambridge anatomist Charles Collignon.

    Science.gov (United States)

    Dittmar, Jenna M; Mitchell, Piers D

    2016-11-01

    This paper aims to highlight the practice of body snatching from graves in the 1700s for the purpose of providing corpses for anatomical dissection, and for stocking anatomy museums. To do this, we examine the exhumation and dissection of the famous eighteenth-century novelist Laurence Sterne and explore the involvement of Charles Collignon, Professor of Anatomy at the University of Cambridge. We also show that osteological and cut-mark analysis of a skull purported to be that of Sterne, currently housed in the Duckworth Collection at Cambridge, provides the key to solving the mystery surrounding why Sterne was resurrected. © The Author(s) 2015.

  7. The Book of Kells: A non-invasive MOLAB investigation by complementary spectroscopic techniques

    Science.gov (United States)

    Doherty, B.; Daveri, A.; Clementi, C.; Romani, A.; Bioletti, S.; Brunetti, B.; Sgamellotti, A.; Miliani, C.

    2013-11-01

    This paper highlights the efficacy of non-invasive portable spectroscopy for assessing the execution technique and constituent materials in one of the most important medieval manuscripts, the Book of Kells. An aimed campaign of in situ measurements by the MObile LABoratory (MOLAB) has analyzed its elemental composition and vibrational and electronic molecular properties. The ample analytical toolbox has afforded complementary diagnostic information of the pigment palette permitting the characterization of both inorganic and organic materials as pigments and dyes in the white, purple, blue, red, orange, green and black areas. In particular, the novel widespread use of calcinated gypsum (anhydrite) as both a white pigment and in correlation to the organic dyes in this manuscript has been noted. The non-invasive identification of the organic dye orchil is significant considering its rare non invasive detection in medieval manuscripts. Finally the occurrence of particular alterations of the organic black areas giving rise to calcium carboxylate and calcium oxalate has been specifically highlighted. Importantly, this work elaborates complex aspects of the employed painting materials which have given rise to numerous significant points of interest for a more elaborate understanding of this Irish treasure.

  8. Hans Jürman 85 : Hans Jürman: kes ma olen? / Hans Jürman

    Index Scriptorium Estoniae

    Jürman, Hans, 1923-2014

    2010-01-01

    Hans Jürmani lapsepõlvest, kooliaastatest ning ülikooliajast. Olles hariduselt eesti filoloog on Hans Jürman töötanud ka apteekrina ja õpetajana, kuid suurema osa oma elust raamatukogudes, põhiliselt Tallinna Keskraamatukogus ja Eesti NSV Riiklikus Avalikus Raamatukogus, viimasel ajal tegeleb terminoloogiaga

  9. Hans Jürman 85 : Hans Jürman: kes ma olen? / Hans Jürman

    Index Scriptorium Estoniae

    Jürman, Hans, 1923-2014

    2010-01-01

    Hans Jürmani lapsepõlvest, kooliaastatest ning ülikooliajast. Olles hariduselt eesti filoloog on Hans Jürman töötanud ka apteekrina ja õpetajana, kuid suurema osa oma elust raamatukogudes, põhiliselt Tallinna Keskraamatukogus ja Eesti NSV Riiklikus Avalikus Raamatukogus, viimasel ajal tegeleb terminoloogiaga

  10. Learning Han Cultures on Horseback

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    The "Think Tank in the Plain of Golden Lotuses" played important roles in the founding of the Yuan Dynasty.It came into being because of the enthusiasm of Kublai towards Han cultures and his political ambitions.

  11. The Hazard Notification System (HANS)

    Science.gov (United States)

    Snedigar, S. F.; Venezky, D. Y.

    2009-12-01

    The Volcano Hazards Program (VHP) has developed a Hazard Notification System (HANS) for distributing volcanic activity information collected by scientists to airlines, emergency services, and the general public. In the past year, data from HANS have been used by airlines to make decisions about diverting or canceling flights during the eruption of Mount Redoubt. HANS was developed to provide a single system that each of the five U.S. volcano observatories could use for communicating and storing volcanic information about the 160+ potentially active U.S. volcanoes. The data that cover ten tables and nearly 100 fields are now stored in similar formats, and the information can be released in styles requested by our agency partners, such as the International Civil Aviation Organization (ICAO). Currently, HANS has about 4500 reports stored; on average, two - three reports are added daily. HANS (at its most basic form) consists of a user interface for entering data into one of many release types (Daily Status Reports, Weekly Updates, Volcano Activity Notifications, etc.); a database holding previous releases as well as observatory information such as email address lists and volcano boilerplates; and a transmission system for formatting releases and sending them out by email or other web related system. The user interface to HANS is completely web based, providing access to our observatory scientists from any online PC. The underlying database stores the observatory information and drives the observatory and program websites' dynamic updates and archived information releases. HANS also runs scripts for generating several different feeds including the program home page Volcano Status Map. Each observatory has the capability of running an instance of HANS. There are currently three instances of HANS and each instance is synchronized to all other instances using a master-slave environment. Information can be entered on any node; slave nodes transmit data to the master node

  12. Bacteria Biomass and Chlorophyll-a depth profiles from bottle casts off the western Antarctic Peninsula from the R/V LAURENCE M. GOULD from 23 April 2001 to 01 September 2001 (NODC Accession 0000820)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Bacteria and Chlorophyll data were collected from bottle cast of the western Antarctic peninsula from the R/V Laurence M. Gould. Data were collected by the...

  13. Produits locaux entre nature et culture : de la ferme voisine au terroir. Entretien avec Laurence Bérard

    Directory of Open Access Journals (Sweden)

    Virginie Amilien

    2005-05-01

    Full Text Available V.A. : Laurence Bérard, vous représentez la moitié du célèbre duo Bérard et Marchenay, dont articles et ouvrages sur produits de terroir en France sont incontournables, et c’est à ce titre que vous nous accordez un entretien aujourd’hui pour le numéro sur les produits alimentaires locaux du journal Anthropology of Food. Alors je commencerais par la traditionnelle question : si je vous dis produits locaux, à quoi pensez-vous ?  L.B. : Produits locaux… et pas de produits de terroir…I.T. : Non j...

  14. Phenotypic Profile of Rh and Kell Blood Group Systems among Blood Donors in Cote d'Ivoire, West Africa

    Science.gov (United States)

    Siransy Bogui, L.; Dembele, B.; Sekongo, Y.; Abisse, S.; Konaté, S.; Sombo, M.

    2014-01-01

    Few countries in sub-Saharan Africa make systematic searches for antigens C, c, E, and e of the Rh and Kell system antigens in the donor and recipient, thereby exposing transfused patients. Purpose and Objectives. In this paper, we propose to determine the red cell Rh and Kell blood groups among blood donors from traditional techniques to improve medical care of transfused patients. This study will allow us to assess the frequency of blood group antigens in these systems. Study Design and Methods. We carried out a study on the red cell typing in the blood donor population of the National Blood Transfusion Center in Abidjan. This study was performed on 651 blood donors. Results. For the Rh system, the antigen frequencies of D, c, e, C, and E are, respectively, 92.93%, 99.85%, 99.85%, 21.97%, and 13.82%. K antigen is found in 0.77% of donors. Discussion and Conclusion. Although the frequencies of the most immunogenic antigens are lower than in the white race, lack of preventive measures makes the immunological risk high in Africa. Furthermore, Africa is full of specificities that are important to note for a better care of our patients. PMID:25328758

  15. En italiensk ridder, hans våpen hans styrke, hans seier og hans fall : Il Cavaliere - Silvio Berlusconi

    OpenAIRE

    Stokke, Alfhild

    2013-01-01

    Denne prosjektoppgavens hovedperson er Silvio Berlusconi. Min hoved-problemstilling er hvordan en av Europas største økonomier har kunnet la seg lede av en så omstridt leder i så mange år. Gjennom underproblemstillingene har jeg diskutert Berlusconi i lys av teori rundt karismatisk og narsissistisk lederskap. Jeg har også sett på hvordan han har taklet det politiske spiller og hvordan han tilegnet seg og utøvet makt. Jeg har anvendt hermeneutikk som metode og foretatt intervjuer med noen utva...

  16. Pola Kellèghãn dan Teknik Vokal Kèjhungan Representasi Ekspresi Budaya Madura dan Pengalaman Estetiknya

    Directory of Open Access Journals (Sweden)

    Zulkarnain Mistortoify

    2014-11-01

    Full Text Available Kèjhungan adalah gaya nyanyian Madura yang memiliki ciri-ciri kontur melodi dengandidominasi nada-nada tinggi, penuh dengan ketegangan suara (nyaring, ekspresif, dan terpola.Kèjhungan seringkali dianalogikan sebagai sebuah bentuk ekspresi “keluh-kesah” semata. Kelantangansuara, ketinggian nada, dan pengolahan melodi yang penuh melismatis mengesankan nyanyian iniseperti orang yang sedang berteriak, membentak, dan merintih-rintih. Penelitian ini dilakukan untukmengungkap hubungan antara karakteristik kèjhungan dengan dunia pengalaman manusia pemiliknya.Oleh karenanya, aspek yang dikaji tidak hanya melihat aspek materi nyanyian itu sendiri, melainkanmelihat pula perilaku menyanyikannya. Melalui analisis struktural-hermeneutik dan pendekatanetnoestetik, ditemukan bahwa kellèghãn (pola-pola kalimat lagu menjadi karakteristik pokok daribentuk kèjhungan dan teknik vokalnya yang bertumpu pada capaian ekspresi yang “menggebu-gebu”.Ide dan konsep yang tergali dibalik itu menunjukkan adanya relasi antara kebiasaan menyanyi orangMadura dengan pengalaman sejarah sosial-budayanya. Hasil penelitian ini menunjukkan bahwanyanyian Madura secara fenomenologis memberikan petunjuk yang sangat jelas sebagai representasidari ekspresi budaya dan pengalaman estetik, khususnya pada sub kultur barat Madura. Kellèghãn Pattern and Kèjhungan Vocal Technique, the Representation of Madurese CulturalExpression and Aesthetic Experience. Kèjhungan is a singing style specific to Madurese. It features thepatterned melodic contour dominated by high pitch vocal, expressiveness, and full of vocal intensity. Maduresekèjhungan is often misperceived only as a form of “moaning” due to its piercing sound, high pitch note, andmelismatic melody. Kèjhungan gives an impression of a person shrieking and moaning at the same time. Thestudy of kèjhungan was conducted to reveal the relationship between the singing characteristic and humanexperiences. Therefore, k

  17. HansTriebel访谈录

    Institute of Scientific and Technical Information of China (English)

    Antonio Caetano; Dorothee Haroske; 李天虹(译); 黄飞敏(校)

    2010-01-01

    Hans Triebel(1936年2月7日出生于Dessau)已于2001年从Friedrich—Schiller—Universitat Jena(德国耶拿市弗里德里希·席勒大学)退休.在1962年获得博士学位和1966年获得教授资格(Habilitation)之后,他在该校当了超过30年的分析领域的讲座教授.

  18. [Hans-Christian Jacobaeus (1879-1937): The inventor of human laparoscopy and thoracoscopy].

    Science.gov (United States)

    Hatzinger, M; Häcker, A; Langbein, S; Kwon, S; Hoang-Böhm, J; Alken, P

    2006-09-01

    Already 94 years ago in 1910, Dr. Hans Christian Jacobaeus performed the first clinical laparoscopic surgery in Stockholm. His pioneering procedure was based on the animal experiments of Georg Kelling (1866-1945), a German physician from Dresden, who performed the first laparoscopic intervention in 1901 using a Nitze cystoscope in a dog. In 1910 Jacobaeus published his first experiences with laparoscopic surgery in the Münchner Medizinische Wochenschrift under the title "The possibility to perform cystoscopy in examinations of serous cavities." He used this technique for diagnostic purposes in unclear abdominal complaints and functional impairment. Jacobaeus was the first who pointed out the possibility of causing injury to organs, especially the gut, by inserting the trocar. In 1910 Jacobaeus recognized the immense diagnostic and therapeutic possibilities of laparoscopic surgery, but also the difficulties and limits. He also was the first who recognized the need to complete training sessions on animals and corpses. He demanded the development of special laparoscopic instruments to optimize and simplify the operation.

  19. Non-Toxic HAN Monopropellant Propulsion Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Non-toxic monopropellants have been developed that provide better performance than toxic hydrazine. Formulations based on hydroxylammonium nitrate (HAN) have...

  20. Non-Toxic HAN Monopropellant Propulsion Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Non-toxic monopropellants have been developed that provide better performance than toxic hydrazine. Formulations based on hydroxylammonium nitrate (HAN) have...

  1. COLONIALISM, HAN & ECO-THEOLOGY

    Directory of Open Access Journals (Sweden)

    Grace Ji-Sun Kim

    2013-06-01

    Full Text Available Today, nations exhibit imperial behaviour but not like the ancient agriculture driven landed empires or the 18-19th century mercantile empires. The land and trade divisions are not as clearly segregated as in the earlier ones, but Imperial nations do exist and do control other nations. Imperialism and colonialism has devastating effects on our world. It has nurtured self-worth through the accumulation of worldly goods for the purposes of serving their own interests and exploiting others for the sole purpose of self-gain. This is devastating not only to human beings but to the whole ecology of the planet. Consumerism drives trade, but consumer buying is now like an unchained beast with tooth and claw causing han for the exploited as well as the resources of the planet. Eco-theologians and feminist theologians examine the devastating effects to help ensure that we are seriously determined to preserve the planet. We will examine ways of rethinking and reimagining our errors and how we can work towards the right direction for a safer, sustainable planet. doi: 10.7833/111-1-15

  2. Book of Kells in Finnegans Wake%《芬尼根的守灵夜》中的《凯尔斯书》

    Institute of Scientific and Technical Information of China (English)

    戴从容

    2014-01-01

    James Joyce’s Finnegans Wake is not only the forerunner of post-modern literature,but also demonstrates the medieval aesthetics which makes it possible to overstep the limit of modernism.Among those texts inthe Middle Ages,Book of Kells is the key to understand the medieval aesthetics in Finnegans Wake.The religious theme in Book of Kells leads Joyce to reconsider the Original Sin and the destiny of mankind from the religious perspective;the richness,complication,variation of the paintings in Book of Kells inspires the rich style and the poetics of sublime in Finnegans Wake.This Paper would illuminate the medieval aesthetics implied in Finnegans Wake which is different from the modern one by analyzing the relationship between Finnegans Wake and Book of Kells.%爱尔兰作家詹姆斯·乔伊斯的《芬尼根的守灵夜》不仅是后现代文学的先驱,而且包含着中世纪美学的因素,这使它得以超越现代主义美学的藩篱。在中世纪的文献中,《凯尔斯书》是理解《芬尼根的守灵夜》中中世纪美学的关键。《凯尔斯书》的宗教主题使乔伊斯在《芬尼根的守灵夜》中重新探讨人类的原罪及其与人类命运的关系;而它在艺术上的丰富、繁杂、变化带来了《芬尼根的守灵夜》的丰富博大感和审美上的崇高。本文试图通过对《芬尼根的守灵夜》与《凯尔斯》书的关系的分析,来揭示《芬尼根的守灵夜》中与现代主义美学不同的中世纪美学内涵。

  3. Temperature, salinity and other variables collected from discrete sample and profile observations using CTD, bottle and other instruments from LAURENCE M. GOULD in the Gulf of Guinea, South Atlantic Ocean and Southern Oceans from 2006-03-23 to 2010-11-02 (NCEI Accession 0144979)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NCEI Accession 0144979 includes discrete sample and profile data collected from LAURENCE M. GOULD in the Gulf of Guinea, South Atlantic Ocean and Southern Oceans...

  4. CHLOROPHYLL A and BACTERIA - BACTERIAL DENSITY ice core data collected in the South Atlantic Ocean and South Pacific Ocean on the LAURENCE M. GOULD and NATHANIEL B. PALMER cruises LMG0106, LMG0205 and others as part of the Southern Ocean GLOBEC project from 2001-07-28 to 2002-09-11 (NODC Accession 0112364)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0112364 includes biological and ice core data collected aboard the LAURENCE M. GOULD and NATHANIEL B. PALMER during cruises LMG0106, LMG0205, NBP0104...

  5. BIOMASS, ANIMALS - INDIVIDUAL - COUNTS, SPECIES IDENTIFICATION, TAXONOMIC CODE and species abundance trawl data collected in the South Atlantic Ocean and South Pacific Ocean on the LAURENCE M. GOULD and NATHANIEL B. PALMER cruises LMG0104, LMG0203 and others as part of the Southern Ocean GLOBEC project from 2001-04-30 to 2002-09-08 (NODC Accession 0112166)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0112166 includes biological and trawl data collected aboard the LAURENCE M. GOULD and NATHANIEL B. PALMER during cruises LMG0104, LMG0203, NBP0104 and...

  6. CHLOROPHYLL A and PHAEOPIGMENTS underway - surface data collected in the South Atlantic Ocean and South Pacific Ocean on the LAURENCE M. GOULD and NATHANIEL B. PALMER cruises LMG0203, NBP0104 and NBP0204 as part of the Southern Ocean GLOBEC project from 2001-08-03 to 2002-09-11 (NODC Accession 0112638)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0112638 includes underway - surface and biological data collected aboard the LAURENCE M. GOULD and NATHANIEL B. PALMER during cruises LMG0203, NBP0104...

  7. Documentation only - no data type documentation only - no observation type data collected in the South Pacific Ocean on the LAURENCE M. GOULD cruise LMG0106 as part of the Southern Ocean GLOBEC project from 2001-08-06 to 2001-11-10 (NODC Accession 0115276)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0115276 includes documentation only - no observation type data collected aboard the LAURENCE M. GOULD during cruise LMG0106 in the South Pacific Ocean...

  8. ANIMALS - INDIVIDUAL - COUNTS, SPECIES IDENTIFICATION - ORGANISM LENGTH, SPECIES IDENTIFICATION - LIFE STAGE, TAXONOMIC CODE and species abundance profile and discrete sample data collected in the South Atlantic Ocean and South Pacific Ocean on the LAURENCE M. GOULD cruises LMG0104 and LMG0203 as part of the Southern Ocean GLOBEC project from 2001-05-01 to 2002-05-10 (NODC Accession 0112167)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0112167 includes profile, discrete sample and biological data collected aboard the LAURENCE M. GOULD during cruises LMG0104 and LMG0203 in the South...

  9. Partial pressure (or fugacity) of carbon dioxide, salinity and other variables collected from Surface underway observations using Carbon dioxide (CO2) gas analyzer, Shower head chamber equilibrator for autonomous carbon dioxide (CO2) measurement and other instruments from LAURENCE M. GOULD in the North Pacific Ocean, South Atlantic Ocean and others from 2004-12-30 to 2005-11-20 (NCEI Accession 0148772)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NCEI Accession 0148772 includes Surface underway data collected from LAURENCE M. GOULD in the North Pacific Ocean, South Atlantic Ocean, South Pacific Ocean and...

  10. Partial pressure (or fugacity) of carbon dioxide, dissolved inorganic carbon, temperature, salinity and other variables collected from discrete sample and profile observations using CTD, Coulometer for DIC measurement and other instruments from LAURENCE M. GOULD in the South Atlantic Ocean and Southern Oceans from 2009-09-16 to 2009-10-09 (NODC Accession 0112845)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NCEI Accession 0112845 includes discrete sample and profile data collected from LAURENCE M. GOULD in the South Atlantic Ocean and Southern Oceans (> 60 degrees...

  11. Partial pressure (or fugacity) of carbon dioxide, salinity and other variables collected from Surface underway observations using Carbon dioxide (CO2) gas analyzer, Shower head chamber equilibrator for autonomous carbon dioxide (CO2) measurement and other instruments from LAURENCE M. GOULD in the North Pacific Ocean, South Atlantic Ocean and others from 2008-12-31 to 2009-12-21 (NCEI Accession 0148771)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NCEI Accession 0148771 includes Surface underway data collected from LAURENCE M. GOULD in the North Pacific Ocean, South Atlantic Ocean, South Pacific Ocean and...

  12. NITRATE + NITRITE CONTENT (CONCENTRATION), PHOSPHATE, DISSOLVED OXYGEN, NITRITE and other profile and discrete sample data collected in the South Atlantic Ocean and South Pacific Ocean on the LAURENCE M. GOULD cruises LMG0104, LMG0106 and others as part of the Southern Ocean GLOBEC project from 2001-04-29 to 2002-09-09 (NODC Accession 0112533)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0112533 includes profile, discrete sample and chemical data collected aboard the LAURENCE M. GOULD during cruises LMG0104, LMG0106, LMG0203 and...

  13. Partial pressure (or fugacity) of carbon dioxide, salinity and other variables collected from Surface underway observations using Carbon dioxide (CO2) gas analyzer, Shower head chamber equilibrator for autonomous carbon dioxide (CO2) measurement and other instruments from LAURENCE M. GOULD in the North Pacific Ocean, South Atlantic Ocean and others from 2008-12-31 to 2009-12-22 (NCEI Accession 0144533)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NCEI Accession 0144533 includes Surface underway data collected from LAURENCE M. GOULD in the North Pacific Ocean, South Atlantic Ocean, South Pacific Ocean and...

  14. WIND DIRECTION, Snow thickness, ICE - TYPE, SPECIES IDENTIFICATION - COUNT and other visual observation data collected in the Indian Ocean, South Atlantic Ocean and South Pacific Ocean on the LAURENCE M. GOULD and NATHANIEL B. PALMER cruises LMG0106, LMG0205 and others as part of the Southern Ocean GLOBEC project from 2001-07-26 to 2002-09-15 (NODC Accession 0112820)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0112820 includes meteorological, visual observation and physical data collected aboard the LAURENCE M. GOULD and NATHANIEL B. PALMER during cruises...

  15. Species abundance profile and discrete sample data collected in the South Atlantic Ocean and South Pacific Ocean on the LAURENCE M. GOULD and NATHANIEL B. PALMER cruises LMG0104, LMG0203 and others as part of the Southern Ocean GLOBEC project from 2001-05-01 to 2002-09-11 (NODC Accession 0112189)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0112189 includes profile, discrete sample and biological data collected aboard the LAURENCE M. GOULD and NATHANIEL B. PALMER during cruises LMG0104,...

  16. INCOMING SOLAR RADIATION time series data collected in the South Pacific Ocean on the LAURENCE M. GOULD cruise LMG0106 as part of the Southern Ocean GLOBEC project from 2001-08-06 to 2001-11-10 (NODC Accession 0112375)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0112375 includes meteorological and time series data collected aboard the LAURENCE M. GOULD during cruise LMG0106 in the South Pacific Ocean from...

  17. CORE - BULK DENSITY, Snow thickness, Snow temperature, Snow type and other site samples data collected in the South Pacific Ocean on the LAURENCE M. GOULD cruises LMG0106 and LMG0205 as part of the Southern Ocean GLOBEC project from 2001-07-28 to 2002-09-08 (NODC Accession 0112865)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0112865 includes site samples, meteorological and physical data collected aboard the LAURENCE M. GOULD during cruises LMG0106 and LMG0205 in the South...

  18. MARINE MAMMALS marine mammal observation data collected in the South Atlantic Ocean and South Pacific Ocean on the LAURENCE M. GOULD and NATHANIEL B. PALMER cruises LMG0103, NBP0103 and NBP0104 as part of the Southern Ocean GLOBEC project from 2001-03-21 to 2001-08-28 (NODC Accession 0112169)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0112169 includes marine mammal observation and biological data collected aboard the LAURENCE M. GOULD and NATHANIEL B. PALMER during cruises LMG0103,...

  19. Partial pressure (or fugacity) of carbon dioxide, salinity and other variables collected from Surface underway observations using Carbon dioxide (CO2) gas analyzer, Shower head chamber equilibrator for autonomous carbon dioxide (CO2) measurement and other instruments from LAURENCE M. GOULD in the North Pacific Ocean, South Atlantic Ocean and others from 2004-12-31 to 2005-12-26 (NCEI Accession 0144531)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NCEI Accession 0144531 includes Surface underway data collected from LAURENCE M. GOULD in the North Pacific Ocean, South Atlantic Ocean, South Pacific Ocean and...

  20. Partial pressure (or fugacity) of carbon dioxide, salinity and other variables collected from Surface underway observations using Carbon dioxide (CO2) gas analyzer, Shower head chamber equilibrator for autonomous carbon dioxide (CO2) measurement and other instruments from LAURENCE M. GOULD in the Caribbean Sea, North Pacific Ocean and others from 2004-01-01 to 2004-12-21 (NCEI Accession 0144538)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NCEI Accession 0144538 includes Surface underway data collected from LAURENCE M. GOULD in the Caribbean Sea, North Pacific Ocean, South Atlantic Ocean, South Pacific...

  1. SPECIES IDENTIFICATION - ORGANISM LENGTH, MARINE MAMMALS, SPECIES IDENTIFICATION, body fat and other marine mammal observation data collected in the South Atlantic Ocean and South Pacific Ocean on the LAURENCE M. GOULD cruises LMG0104, LMG0106 and others as part of the Southern Ocean GLOBEC project from 2001-05-05 to 2002-09-09 (NODC Accession 0112821)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0112821 includes marine mammal observation and biological data collected aboard the LAURENCE M. GOULD during cruises LMG0104, LMG0106, LMG0203 and...

  2. Partial pressure (or fugacity) of carbon dioxide, salinity and other variables collected from Surface underway observations using Carbon dioxide (CO2) gas analyzer, Shower head chamber equilibrator for autonomous carbon dioxide (CO2) measurement and other instruments from LAURENCE M. GOULD in the Caribbean Sea, North Pacific Ocean and others from 2004-01-02 to 2004-12-21 (NCEI Accession 0148768)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NCEI Accession 0148768 includes Surface underway data collected from LAURENCE M. GOULD in the Caribbean Sea, North Pacific Ocean, South Atlantic Ocean, South Pacific...

  3. Snow thickness, Freeboard, cloud amount/frequency, Albedo and other site samples data collected in the South Pacific Ocean on the LAURENCE M. GOULD cruises LMG0106 and LMG0205 as part of the Southern Ocean GLOBEC project from 2001-08-07 to 2002-09-08 (NODC Accession 0112864)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0112864 includes site samples, meteorological and physical data collected aboard the LAURENCE M. GOULD during cruises LMG0106 and LMG0205 in the South...

  4. PIGMENTS, growth rate and Condition factor site samples data collected in the South Atlantic Ocean and South Pacific Ocean on the LAURENCE M. GOULD cruises LMG0106 and LMG0205 as part of the Southern Ocean GLOBEC project from 2001-07-28 to 2002-09-09 (NODC Accession 0112636)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0112636 includes site samples and biological data collected aboard the LAURENCE M. GOULD during cruises LMG0106 and LMG0205 in the South Atlantic...

  5. ANIMALS - INDIVIDUAL - COUNTS, Displacement Volume, SPECIES IDENTIFICATION - LIFE STAGE, TAXONOMIC CODE and species abundance profile and discrete sample data collected in the South Atlantic Ocean and South Pacific Ocean on the LAURENCE M. GOULD cruises LMG0104 and LMG0203 as part of the Southern Ocean GLOBEC project from 2001-05-01 to 2002-05-10 (NODC Accession 0112170)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0112170 includes profile, discrete sample and biological data collected aboard the LAURENCE M. GOULD during cruises LMG0104 and LMG0203 in the South...

  6. SPECIES IDENTIFICATION - ORGANISM LENGTH, growth rate and SPECIES IDENTIFICATION - LIFE STAGE site samples data collected in the South Atlantic Ocean and South Pacific Ocean on the LAURENCE M. GOULD cruises LMG0106 and LMG0205 as part of the Southern Ocean GLOBEC project from 2001-07-28 to 2002-09-05 (NODC Accession 0112634)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0112634 includes site samples and biological data collected aboard the LAURENCE M. GOULD during cruises LMG0106 and LMG0205 in the South Atlantic...

  7. PIGMENTS, SPECIES IDENTIFICATION - LIFE STAGE and SPECIES IDENTIFICATION - WET WEIGHT site samples data collected in the South Pacific Ocean on the LAURENCE M. GOULD cruises LMG0106 and LMG0205 as part of the Southern Ocean GLOBEC project from 2001-08-06 to 2002-09-09 (NODC Accession 0112635)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0112635 includes site samples and biological data collected aboard the LAURENCE M. GOULD during cruises LMG0106 and LMG0205 in the South Pacific Ocean...

  8. CHLOROPHYLL A and BACTERIA - BACTERIAL DENSITY profile data collected in the South Pacific Ocean on the LAURENCE M. GOULD cruises LMG0104 and LMG0106 as part of the Southern Ocean GLOBEC project from 2001-04-29 to 2001-08-20 (NODC Accession 0112521)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0112521 includes profile and biological data collected aboard the LAURENCE M. GOULD during cruises LMG0104 and LMG0106 in the South Pacific Ocean from...

  9. Partial pressure (or fugacity) of carbon dioxide, dissolved inorganic carbon, temperature, salinity and other variables collected from discrete sample and profile observations using CTD, Carbon dioxide (CO2) gas analyzer and other instruments from the LAURENCE M. GOULD in the South Atlantic Ocean from 2006-03-21 to 2006-04-04 (NODC Accession 0108070)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0108070 includes chemical, discrete sample, physical and profile data collected from LAURENCE M. GOULD in the South Atlantic Ocean from 2006-03-21 to...

  10. SPECIES IDENTIFICATION - DRY WEIGHT, SPECIES IDENTIFICATION - ORGANISM LENGTH, Condition factor, Carbon content of specimen and Nitrogen content of specimen site samples data collected in the South Atlantic Ocean and South Pacific Ocean on the LAURENCE M. GOULD cruises LMG0106 and LMG0205 as part of the Southern Ocean GLOBEC project from 2001-07-29 to 2002-09-09 (NODC Accession 0112563)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0112563 includes site samples and biological data collected aboard the LAURENCE M. GOULD during cruises LMG0106 and LMG0205 in the South Atlantic...

  11. MARINE MAMMALS and WATER TEMPERATURE marine mammal observation data collected in the South Atlantic Ocean and South Pacific Ocean on the LAURENCE M. GOULD cruises LMG0104, LMG0106 and others as part of the Southern Ocean GLOBEC project from 2001-05-07 to 2002-10-25 (NODC Accession 0112822)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0112822 includes marine mammal observation, biological and physical data collected aboard the LAURENCE M. GOULD during cruises LMG0104, LMG0106,...

  12. Hans Christian Andersen ja Põhjamaade muinasjutud

    Index Scriptorium Estoniae

    2005-01-01

    Narva kultuurimajas etendub teater Varius etendus "Jutustan teile oma lugu", mis põhineb Hans Christian Anderseni elulool. Põhjamaade Ministrite Nõukogu esindus Eestis kingib Narva Linnavalitsusele 20 venekeelset Põhjamaade muinasjuttude kogumikku

  13. Catherine Sauviat et Laurence Lizé, La crise du modèle social américain, Rennes, Presses Universitaires de Rennes, 2010

    Directory of Open Access Journals (Sweden)

    Evelyne Thévenard

    2011-04-01

    Full Text Available Dans cet ouvrage publié juste avant l’adoption par le Congrès américain d’une réforme sociale majeure (le Patient Protection and Affordable Care Act, Catherine Sauviat et Laurence Lizé, économistes à l’Institut de recherches économiques et sociales, analysent les facteurs ayant contribué à la dégradation du « modèle social américain » mis en place pendant le New Deal et la période de prospérité de l’après-guerre, entraînant la montée de la précarité et l’aggravation des inégalités. Le concep...

  14. Donna Haraway, Manifeste cyborg et autres essais. Sciences-Fictions-Féminismes. Anthologie établie par Laurence Allard, Delphine Gardey et Nathalie Magnan

    Directory of Open Access Journals (Sweden)

    Irène Jami

    2008-12-01

    Full Text Available Il faut saluer l’heureuse initiative et la qualité de la réalisation de Laurence Allard, Delphine Gardey et Nathalie Magnan, relayées par les éditions Exils : mettre à notre disposition en français, et dans une langue claire et agréable en dépit de la difficulté de l’entreprise de traduction, des textes parmi les plus significatifs de l’œuvre de Donna Haraway. Après Judith Butler et Teresa de Lauretis, nous voici donc en mesure de nous familiariser – avec dix à vingt ans de délai, mais ce n’e...

  15. Roheline koletis / Laurence Lumiere

    Index Scriptorium Estoniae

    Lumiere, Laurence

    2008-01-01

    Koomiksipõhine seiklusfilm "Unustamatu Hulk" ("The Incredible Hulk") : stsenaristid Stan Lee ja Jack Kirby koomiksisarja alusel Zak Penn ning Edward Norton, kes kehastab ka peategelast : Ameerika Ühendriigid 2008. Lisatud nimekiri "20 edukamat koomiksifilmi Põhja-Ameerikas"

  16. Supermani esiisa / Laurence Lumiere

    Index Scriptorium Estoniae

    Lumiere, Laurence

    2007-01-01

    Anglosaksi eepose "Beowulf" alusel on valminud samanimeline USA seiklusfilm : stsenaristid Neil Gaiman, Roger Avary : režissöör Robert Zemeckis : osades Anthony Hopkins, Angelina Jolie, Ray Winstone

  17. Roheline koletis / Laurence Lumiere

    Index Scriptorium Estoniae

    Lumiere, Laurence

    2008-01-01

    Koomiksipõhine seiklusfilm "Unustamatu Hulk" ("The Incredible Hulk") : stsenaristid Stan Lee ja Jack Kirby koomiksisarja alusel Zak Penn ning Edward Norton, kes kehastab ka peategelast : Ameerika Ühendriigid 2008. Lisatud nimekiri "20 edukamat koomiksifilmi Põhja-Ameerikas"

  18. A structural query system for Han characters

    DEFF Research Database (Denmark)

    Skala, Matthew

    2016-01-01

    The IDSgrep structural query system for Han character dictionaries is presented. This dictionary search system represents the spatial structure of Han characters using Extended Ideographic Description Sequences (EIDSes), a data model and syntax based on the Unicode IDS concept. It includes a query...... language for EIDS databases, with a freely available implementation and format translation from popular third-party IDS and XML character databases. The system is designed to suit the needs of font developers and foreign language learners. The search algorithm includes a bit vector index inspired by Bloom...

  19. Molecular basis of two novel and related high-prevalence antigens in the Kell blood group system, KUCI and KANT, and their serologic and spatial association with K11 and KETI.

    Science.gov (United States)

    Velliquette, Randall W; Hue-Roye, Kim; Lomas-Francis, Christine; Gillen, Barbara; Schierts, Jennifer; Gentzkow, Kristie; Peyrard, Thierry; von Zabern, Inge; Flegel, Willy A; Rodberg, Karen; Debnath, Asim K; Lee, Soohee; Reid, Marion E

    2013-11-01

    The numerous antigens in the Kell blood group system result from missense nucleotide changes in KEL. Antibodies to antigens in this system can be clinically important. We describe six probands whose plasma contained antibodies to high-prevalence Kell antigens and discuss their relationship. Polymerase chain reaction amplification, direct sequencing, restriction fragment length polymorphism assays, hemagglutination, flow cytometry, and protein modeling were performed by standard methods. Proband 1 (KUCI) and her serologically compatible sister were heterozygous for a nucleotide change in Exon 11 (KEL*1271C/T; Ala424Val). Proband 2 (KANT) was heterozygous for KEL*1283G/T (Arg428Leu) and KEL*1216C/T (Arg406Stop) in Exon 11. Red blood cells (RBCs) from Proband 1 and her sister were not agglutinated by plasma from Proband 2; however, RBCs from Proband 2 were agglutinated by plasma from Proband 1. Probands 3, 4, 5, and 6 had the KEL*1391C>T change associated with the previously reported KETI- phenotype. Proband 5 was also homozygous for KEL*905T>C encoding the K11-K17+ phenotype. Hemagglutination studies revealed an association between KUCI, KANT, KETI, and K11. Protein modeling indicated that whereas Ala424 and Arg428 are clustered, Val302 and Thr464 are not. Ala424 in the Kell glycoprotein is associated with the high-prevalence Kell antigen, KUCI (ISBT 006032), which is detected by the antibody of Proband 1. Arg428 is associated with the high-prevalence Kell antigen, KANT (ISBT 006033). The association between KUCI, KANT, KETI, and K11 and the results of protein modeling are discussed. © 2013 New York Blood Center. Transfusion © 2013 American Association of Blood Banks.

  20. Hans Pöhl - Estlandssvenskarnas hövding = Hans Pöhl - rannarootslaste eestvõitleja / Torkel Jansson

    Index Scriptorium Estoniae

    Jansson, Torkel, 1947-

    2011-01-01

    Raamatututvustus: Hans Pöhl - Estlandssvenskarnas hövding : en biografi över Hans Pöhl (1876-1930), estlandssvenskarnas främste företrädare och ledare = Hans Pöhl - rannarootslaste eestvõitleja : Hans Pöhli (1876-1930), Eesti rootslaste vaimse liidri ja valgustaja elulugu. (Stockholm ; Tallinn, 2010)

  1. Obituary: Hans Albrecht Bethe, 1906-2005

    NARCIS (Netherlands)

    Wijers, R.

    2007-01-01

    One of the unquestioned giants of physics and astrophysics, Hans Bethe, died on 6 March 2005, at the venerable age of 98, in his home town of Ithaca, New York. Seven decades of contributing to research and a Nobel Prize for his work on stellar hydrogen burning make a listing of his honors superfluou

  2. Commemorate World-Famous Writer Han Suyin

    Institute of Scientific and Technical Information of China (English)

    Chuan; You

    2014-01-01

    <正>November 2,2013 marked the 1 st anniversary of the passing of the famous Anglo-Chinese writer Han Suyin.A memorial meeting jointly sponsored by the Sichuan Provincial People’s Association for Friendship with Foreign Countries(SIFA),the Sichuan Provincial Writers Association and the Culture and Sport Bureau of

  3. Hans Tausen: Kampen for en dansk Luther

    DEFF Research Database (Denmark)

    Dreyer, Rasmus Hoeg Colbjørn

    2011-01-01

    , hvis teologi bl.a. Hans Poulsen Resen identificerede som 'zwingliansk'. Pietismen og rationalismen (i en anden halvdel af det 18. århundrede) forsvarede derimod Tausen og benævnte ham endog 'den danske Luther' (Erich Pontoppidan), pga. det de antog at være særligt 'lutherske' aspekter i Tausens teologi...

  4. Obituary: Hans Albrecht Bethe, 1906-2005

    NARCIS (Netherlands)

    Wijers, R.

    2007-01-01

    One of the unquestioned giants of physics and astrophysics, Hans Bethe, died on 6 March 2005, at the venerable age of 98, in his home town of Ithaca, New York. Seven decades of contributing to research and a Nobel Prize for his work on stellar hydrogen burning make a listing of his honors superfluou

  5. Applied Mathematics, the Hans van Duijn way

    CERN Document Server

    Peletier, Mark A

    2012-01-01

    This is a former PhD student's take on his teacher's scientific philosophy. I describe a set of 'principles' that I believe are conducive to good applied mathematics, and that I have learnt myself from observing Hans van Duijn in action.

  6. Hans Eysenck (1916-1997): A Tribute.

    Science.gov (United States)

    Sternberg, Robert J.

    1997-01-01

    Hans Eysenck, who died in September 1997, was one of the most well-known psychologists in the world. A believer that intelligence is genetically controlled, Eysenck recognized the need for scientific investigation in the study of intelligence and creativity. He was characterized by extraordinary creativity and commitment to his scientific message.…

  7. Written Treasures of the Mawangdui Han Tomb

    Institute of Scientific and Technical Information of China (English)

    1993-01-01

    BEFORE paper-makingwas invented in China,bamboo or wooden slipsand silk were used for writtenmaterials.The following an-cient writings were all doneon bamboo slips:documentsunearthed in the Chu tombs inBaoshan in Hubei Province;Artof War by Sunzi,a famousChinese classic about militarystrategy and tactics,unearthedin the Han tombs in Yinques-

  8. An interview with Mark G. Hans

    Science.gov (United States)

    Bolognese, Ana Maria; Palomo, Juan Martin; Miyashita, Kunihiko; Nojima, Lincoln Issamu; Nojima, Matilde da Cunha Gonçalves

    2014-01-01

    It is a great honor to conduct an interview with Professor Mark G. Hans, after following his outstanding work ahead of the Bolton-Brush Growth Study Center and the Department of Orthodontics at the prestigious Case Western Reserve School of Dental Medicine (CWRU) in Cleveland, Ohio. Born in Berea, Ohio, Professor Mark Hans attended Yale University in New Haven, CT, and earned his Bachelor of Science Degree in Chemistry. Upon graduation, Dr. Hans received his DDS and Masters Degree of Science in Dentistry with specialty certification in Orthodontics at Case Western Reserve University. During his education, Dr. Hans' Master's Thesis won the Harry Sicher Award for Best Research by an Orthodontic Student and being granted a Presidential Teaching Fellowship. As one of the youngest doctors ever certified by the American Board of Orthodontics, Dr. Hans continues to maintain his board certification. He has worked through academics on a variety of research interests, that includes the demographics of orthodontic practice, digital radiographic data, dental and craniofacial genetics, as obstructive sleep apnea syndrome, with selected publications in these fields. One of his noteworthy contributions to the orthodontic literature came along with Dr. Donald Enlow on the pages of "Essentials of Facial Growth", being reference on the study of craniofacial growth and development. Dr. Mark Hans's academic career is linked to CWRU, recognized as the renowned birthplace of research on craniofacial growth and development, where the classic Bolton-Brush Growth Study was historically set. Today, Dr. Hans is the Director of The Bolton-Brush Growth Study Center, performing, with great skill and dedication, the handling of the larger longitudinal sample of bone growth study. He is Associate Dean for Graduate Studies, Professor and Chairman of the Department of Orthodontics, working in clinical and theoretical activities with students of the Undergraduate Course from the School of Dental

  9. Review: Udo Kelle (2007. Die Integration qualitativer und quantitativer Methoden in der empirischen Sozialforschung [Integrating Qualitative and Quantitative Methods in Empirical Social Research: Theoretical Foundations and Methodological Concepts

    Directory of Open Access Journals (Sweden)

    Jeannette Bischkopf

    2008-07-01

    Full Text Available Udo KELLE adds to the debate on integrating qualitative and quantitative methods by going beyond epistemological and pragmatic arguments and placing a stronger emphasis on the area of research and the actual research questions addressed empirically in social science. The fact that social scientific research mainly involves middle-range theories poses specific methodological problems for each of the two research traditions and makes their combination inevitable. The integrative methodological program the author develops can be understood as a new guiding program for evaluating the strengths and weaknesses of qualitative as well as quantitative methods and for deciding in which area of research and for which research questions each methods is best suited. The book provides a wealth of arguments for a theoretical and methodological integration of the two research traditions but these arguments could have been made more accessible by including more examples from actual research projects. URN: urn:nbn:de:0114-fqs080386

  10. Transforming han: a correlational method for psychology and religion.

    Science.gov (United States)

    Oh, Whachul

    2015-06-01

    Han is a destructive feeling in Korea. Although Korea accomplished significant exterior growth, Korean society is still experiencing the dark aspects of transforming han as evidenced by having the highest suicide rate in Asia. Some reasons for this may be the fragmentation between North and South Korea. If we can transform han then it can become constructive. I was challenged to think of possibilities for transforming han internally; this brings me to the correlational method through psychological and religious interpretation. This study is to challenge and encourage many han-ridden people in Korean society. Through the psychological and religious understanding of han, people suffering can positively transform their han. They can relate to han more subjectively, and this means the han-ridden psyche has an innate sacredness of potential to transform.

  11. Hans Teiv : mina sellel kohal igavuse üle ei kurda / Hans Teiv ; interv. Heli Salong

    Index Scriptorium Estoniae

    Teiv, Hans

    2004-01-01

    Saare maavanema kohusetäitja ja kandidaat Hans Teiv hindab oma võimalusi saada ametisse kinnitatud, räägib oma tegevusest maavalitsuse osakonnajuhataja ja maakonna juhina ning tutvustab Saaremaa arenguvisioone

  12. Hans Lepp : ainult tänu kodueestlastele on Eesti olemas / Hans Lepp ; interv. Kalev Vilgats

    Index Scriptorium Estoniae

    Lepp, Hans, 1950-

    2007-01-01

    Rootsi instituudi praegune kultuurinõunik Hans Lepp töötas esimese kultuuriatasheena taas avatud Rootsi suursaatkonnas. Töötamisest Rootsi instituudis, riigi välispoliitikast, suhetest Venemaaga, aprillisündmustest jm

  13. Hans Viertler: professor, cientista, gestor e amigo Hans Viertler: professor, scientist, manager and friend

    Directory of Open Access Journals (Sweden)

    Jailson B. de Andrade

    2010-01-01

    Full Text Available Hans Viertler, a visionary, an example of institutional commitment, a great scientist, excellent and dedicated teacher, highly respected as a professional and admired for his leadership, wisdom, generosity, good humor, professional capacity, and balance. A life dedicated to the consolidation of Chemistry in Brazil, the teaching chemistry, the IQ-USP, the Brazilian Chemical Society (SBQ and the CRQ-fourth region. Hans, a friend with a heart bigger than himself!

  14. An interview with Mark G. Hans.

    Science.gov (United States)

    Hans, Mark G; Nojima, Matilde da Cunha Gonçalves

    2014-01-01

    It is a great honor to conduct an interview with Professor Mark G. Hans, after following his outstanding work ahead of the Bolton-Brush Growth Study Center and the Department of Orthodontics at the prestigious Case Western Reserve School of Dental Medicine (CWRU) in Cleveland, Ohio. Born in Berea, Ohio, Professor Mark Hans attended Yale University in New Haven, CT, and earned his Bachelor of Science Degree in Chemistry. Upon graduation, Dr. Hans received his DDS and Masters Degree of Science in Dentistry with specialty certification in Orthodontics at Case Western Reserve University. During his education, Dr. Hans’ Master’s Thesis won the Harry Sicher Award for Best Research by an Orthodontic Student and being granted a Presidential Teaching Fellowship. As one of the youngest doctors ever certified by the American Board of Orthodontics, Dr. Hans continues to maintain his board certification. He has worked through academics on a variety of research interests, that includes the demographics of orthodontic practice, digital radiographic data, dental and craniofacial genetics, as obstructive sleep apnea syndrome, with selected publications in these fields. One of his noteworthy contributions to the orthodontic literature came along with Dr. Donald Enlow on the pages of “Essentials of Facial Growth”, being reference on the study of craniofacial growth and development. Dr. Mark Hans’s academic career is linked to CWRU, recognized as the renowned birthplace of research on craniofacial growth and development, where the classic Bolton-Brush Growth Study was historically set. Today, Dr. Hans is the Director of The Bolton-Brush Growth Study Center, performing, with great skill and dedication, the handling of the larger longitudinal sample of bone growth study. He is Associate Dean for Graduate Studies, Professor and Chairman of the Department of Orthodontics, working in clinical and theoretical activities with students of the Undergraduate Course from the School of

  15. JONAS, HANS, Memorias. Por Juan Arana

    Directory of Open Access Journals (Sweden)

    Juan Arana

    2012-05-01

    Full Text Available Autor: Hans Jonas (2005. Editorial: Losada, Madrid. Traducción: Illana Giner Comín. Basadas en las conversaciones con Rachel Salamander. Proemiode Lore Jonas. Prólogo de Rachel Salamander. Editor: Christian Wiese. Hans Jonas forma parte, con Koestler,Popper, Heidegger o Wittgenstein, del selecto grupo de pensadores y escritores a quienes tocó vivir en primera persona gran parte de las peripecias del turbulento siglo XX. Pero, como en todo, hay diferencias.La trayectoria vital de Jonas no dibuja el perfil de una desmesura excéntrica, como la de Wittgenstein, ni de una tenaz ambición teórica, como la de Popper, ni de un lamentable olvido del prójimo, como la de Heidegger, ni de un aventurismo desquiciado, como la de Koestler.

  16. Hans Wolter - a pioneer of applied optics

    CERN Document Server

    Schrimpf, Andreas

    2016-01-01

    Applied optics was one of the major topics Hans Walter was engaged in during his scientific life. He contributed to the understanding of optical properties of thin films, which could be used to design coating layers to improve the properties of optical and other surfaces. He developed the theoretical description of the basic principles of phase-contrast, schlieren and interference optics applied to enhance low contrast details and to increase the resolution in studies of biological samples. And last, but not least, Hans Wolter proposed an optical system of two grazing--incidence mirrors for use in an X--ray imaging microscope. A microscope using such an optics never was put into practice, but the optical design turned out to be well suited for telescopes.

  17. Nontoxic Hydroxylammonium Nitrate (HAN) Monopropellant Propulsion

    Science.gov (United States)

    McKechnie, Timothy N.

    2015-01-01

    Nontoxic monopropellants have been developed that provide better performance than toxic hydrazine. Formulations based on HAN have superior performance as compared to hydrazine with enhanced specific impulse (Isp), higher density and volumetric impulse, lower melting point, and much lower toxicity. However, HAN-based monopropellants require higher chamber temperatures (2,083 K vs. 883 K) to combust. Current hydrazine-based combustion chamber technology (Inconel® or niobium C103 and silicide coating) and catalyst (Shell 405) are inadequate. In Phase I, state-of-the-art iridium-lined rhenium chambers and innovative new foam catalysts were demonstrated in pulse and 10-second firings. Phase II developed and tested a flight-weight thruster for an environmentally green monopropellant.

  18. Hans Strand:大地诗人

    Institute of Scientific and Technical Information of China (English)

    烁朱; Hans; Strand

    2012-01-01

    Hans Strand与很多摄影家不同。在他整个青少年时期,都和摄影没有任何瓜葛,第一次拍照甚至到了大学快毕业的时候。但是,这并不妨碍他后来成为举世瞩目的自然摄影家。这位1955年出生于瑞

  19. Partial pressure (or fugacity) of carbon dioxide, salinity and other variables collected from Surface underway observations using Carbon dioxide (CO2) gas analyzer, Shower head chamber equilibrator for autonomous carbon dioxide (CO2) measurement and other instruments from LAURENCE M. GOULD in the South Atlantic Ocean, South Pacific Ocean and Southern Oceans from 2011-12-30 to 2012-12-23 (NCEI Accession 0148774)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NCEI Accession 0148774 includes Surface underway data collected from LAURENCE M. GOULD in the South Atlantic Ocean, South Pacific Ocean and Southern Oceans (> 60...

  20. Partial pressure (or fugacity) of carbon dioxide, salinity and other variables collected from Surface underway observations using Carbon dioxide (CO2) gas analyzer, Shower head chamber equilibrator for autonomous carbon dioxide (CO2) measurement and other instruments from LAURENCE M. GOULD in the South Atlantic Ocean, South Pacific Ocean and Southern Oceans from 2002-03-23 to 2002-12-23 (NCEI Accession 0148766)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NCEI Accession 0148766 includes Surface underway data collected from LAURENCE M. GOULD in the South Atlantic Ocean, South Pacific Ocean and Southern Oceans (> 60...

  1. Partial pressure (or fugacity) of carbon dioxide, salinity and other variables collected from Surface underway observations using Carbon dioxide (CO2) gas analyzer, Shower head chamber equilibrator for autonomous carbon dioxide (CO2) measurement and other instruments from LAURENCE M. GOULD in the South Atlantic Ocean, South Pacific Ocean and Southern Oceans from 2011-01-02 to 2011-12-18 (NCEI Accession 0148767)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NCEI Accession 0148767 includes Surface underway data collected from LAURENCE M. GOULD in the South Atlantic Ocean, South Pacific Ocean and Southern Oceans (> 60...

  2. Partial pressure (or fugacity) of carbon dioxide, salinity and other variables collected from Surface underway observations using Carbon dioxide (CO2) gas analyzer, Shower head chamber equilibrator for autonomous carbon dioxide (CO2) measurement and other instruments from LAURENCE M. GOULD in the South Atlantic Ocean, South Pacific Ocean and Southern Oceans from 2010-01-01 to 2011-12-19 (NCEI Accession 0148765)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NCEI Accession 0148765 includes Surface underway data collected from LAURENCE M. GOULD in the South Atlantic Ocean, South Pacific Ocean and Southern Oceans (> 60...

  3. Partial pressure (or fugacity) of carbon dioxide, salinity and other variables collected from Surface underway observations using Carbon dioxide (CO2) gas analyzer, Shower head chamber equilibrator for autonomous carbon dioxide (CO2) measurement and other instruments from LAURENCE M. GOULD in the South Atlantic Ocean, South Pacific Ocean and Southern Oceans from 2014-01-01 to 2014-12-20 (NCEI Accession 0145200)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NCEI Accession 0145200 includes Surface underway data collected from LAURENCE M. GOULD in the South Atlantic Ocean, South Pacific Ocean and Southern Oceans (> 60...

  4. Partial pressure (or fugacity) of carbon dioxide, salinity and other variables collected from Surface underway observations using Carbon dioxide (CO2) gas analyzer, Shower head chamber equilibrator for autonomous carbon dioxide (CO2) measurement and other instruments from LAURENCE M. GOULD in the South Atlantic Ocean, South Pacific Ocean and Southern Oceans from 2007-01-02 to 2007-12-22 (NCEI Accession 0144528)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NCEI Accession 0144528 includes Surface underway data collected from LAURENCE M. GOULD in the South Atlantic Ocean, South Pacific Ocean and Southern Oceans (> 60...

  5. Partial pressure (or fugacity) of carbon dioxide, salinity and other variables collected from Surface underway observations using Carbon dioxide (CO2) gas analyzer, Shower head chamber equilibrator for autonomous carbon dioxide (CO2) measurement and other instruments from LAURENCE M. GOULD in the South Atlantic Ocean, South Pacific Ocean and Southern Oceans from 2002-12-29 to 2003-11-30 (NCEI Accession 0144351)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NCEI Accession 0144351 includes Surface underway data collected from LAURENCE M. GOULD in the South Atlantic Ocean, South Pacific Ocean and Southern Oceans (> 60...

  6. Partial pressure (or fugacity) of carbon dioxide, salinity and other variables collected from Surface underway observations using Carbon dioxide (CO2) gas analyzer, Shower head chamber equilibrator for autonomous carbon dioxide (CO2) measurement and other instruments from LAURENCE M. GOULD in the South Atlantic Ocean, South Pacific Ocean and Southern Oceans from 2007-12-30 to 2008-10-28 (NCEI Accession 0144348)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NCEI Accession 0144348 includes Surface underway data collected from LAURENCE M. GOULD in the South Atlantic Ocean, South Pacific Ocean and Southern Oceans (> 60...

  7. Partial pressure (or fugacity) of carbon dioxide, salinity and SEA SURFACE TEMPERATURE collected from underway - surface observations using Carbon dioxide (CO2) gas analyzer, Shower head chamber equilibrator for autonomous carbon dioxide (CO2) measurement and other instruments from the LAURENCE M. GOULD in the Caribbean Sea, North Pacific Ocean and others from 2002-03-07 to 2012-11-24 (NODC Accession 0083196)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0083196 includes chemical, physical and underway - surface data collected from LAURENCE M. GOULD in the Caribbean Sea, North Pacific Ocean, South...

  8. Partial pressure (or fugacity) of carbon dioxide, salinity and other variables collected from Surface underway observations using Carbon dioxide (CO2) gas analyzer, Shower head chamber equilibrator for autonomous carbon dioxide (CO2) measurement and other instruments from LAURENCE M. GOULD in the South Atlantic Ocean, South Pacific Ocean and Southern Oceans from 2006-01-02 to 2006-12-26 (NCEI Accession 0148764)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NCEI Accession 0148764 includes Surface underway data collected from LAURENCE M. GOULD in the South Atlantic Ocean, South Pacific Ocean and Southern Oceans (> 60...

  9. Partial pressure (or fugacity) of carbon dioxide, salinity and other variables collected from Surface underway observations using Carbon dioxide (CO2) gas analyzer, Shower head chamber equilibrator for autonomous carbon dioxide (CO2) measurement and other instruments from LAURENCE M. GOULD in the South Atlantic Ocean, South Pacific Ocean and Southern Oceans from 2007-01-02 to 2007-12-20 (NCEI Accession 0148773)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NCEI Accession 0148773 includes Surface underway data collected from LAURENCE M. GOULD in the South Atlantic Ocean, South Pacific Ocean and Southern Oceans (> 60...

  10. Partial pressure (or fugacity) of carbon dioxide, salinity and other variables collected from Surface underway observations using Carbon dioxide (CO2) gas analyzer, Shower head chamber equilibrator for autonomous carbon dioxide (CO2) measurement and other instruments from LAURENCE M. GOULD in the South Atlantic Ocean, South Pacific Ocean and Southern Oceans from 2012-12-31 to 2013-11-15 (NCEI Accession 0144529)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NCEI Accession 0144529 includes Surface underway data collected from LAURENCE M. GOULD in the South Atlantic Ocean, South Pacific Ocean and Southern Oceans (> 60...

  11. Partial pressure (or fugacity) of carbon dioxide, salinity and other variables collected from Surface underway observations using Carbon dioxide (CO2) gas analyzer, Shower head chamber equilibrator for autonomous carbon dioxide (CO2) measurement and other instruments from LAURENCE M. GOULD in the South Atlantic Ocean, South Pacific Ocean and Southern Oceans from 2014-12-30 to 2015-05-11 (NCEI Accession 0148769)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NCEI Accession 0148769 includes Surface underway data collected from LAURENCE M. GOULD in the South Atlantic Ocean, South Pacific Ocean and Southern Oceans (> 60...

  12. Partial pressure (or fugacity) of carbon dioxide, salinity and other variables collected from Surface underway observations using Carbon dioxide (CO2) gas analyzer, Shower head chamber equilibrator for autonomous carbon dioxide (CO2) measurement and other instruments from LAURENCE M. GOULD in the South Atlantic Ocean, South Pacific Ocean and Southern Oceans from 2006-01-01 to 2006-12-27 (NCEI Accession 0144535)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NCEI Accession 0144535 includes Surface underway data collected from LAURENCE M. GOULD in the South Atlantic Ocean, South Pacific Ocean and Southern Oceans (> 60...

  13. Partial pressure (or fugacity) of carbon dioxide, salinity and other variables collected from Surface underway observations using Carbon dioxide (CO2) gas analyzer, Shower head chamber equilibrator for autonomous carbon dioxide (CO2) measurement and other instruments from LAURENCE M. GOULD in the South Atlantic Ocean, South Pacific Ocean and Southern Oceans from 2002-03-07 to 2002-12-23 (NCEI Accession 0144356)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NCEI Accession 0144356 includes Surface underway data collected from LAURENCE M. GOULD in the South Atlantic Ocean, South Pacific Ocean and Southern Oceans (> 60...

  14. Partial pressure (or fugacity) of carbon dioxide, salinity and other variables collected from Surface underway observations using Carbon dioxide (CO2) gas analyzer, Shower head chamber equilibrator for autonomous carbon dioxide (CO2) measurement and other instruments from LAURENCE M. GOULD in the South Atlantic Ocean, South Pacific Ocean and Southern Oceans from 2011-01-02 to 2011-12-19 (NCEI Accession 0144354)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NCEI Accession 0144354 includes Surface underway data collected from LAURENCE M. GOULD in the South Atlantic Ocean, South Pacific Ocean and Southern Oceans (> 60...

  15. Partial pressure (or fugacity) of carbon dioxide, salinity and other variables collected from Surface underway observations using Carbon dioxide (CO2) gas analyzer, Shower head chamber equilibrator for autonomous carbon dioxide (CO2) measurement and other instruments from LAURENCE M. GOULD in the South Atlantic Ocean, South Pacific Ocean and Southern Oceans from 2007-12-31 to 2008-10-27 (NCEI Accession 0148763)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NCEI Accession 0148763 includes Surface underway data collected from LAURENCE M. GOULD in the South Atlantic Ocean, South Pacific Ocean and Southern Oceans (> 60...

  16. Partial pressure (or fugacity) of carbon dioxide, salinity and other variables collected from Surface underway observations using Carbon dioxide (CO2) gas analyzer, Shower head chamber equilibrator for autonomous carbon dioxide (CO2) measurement and other instruments from LAURENCE M. GOULD in the South Atlantic Ocean, South Pacific Ocean and Southern Oceans from 2003-01-01 to 2003-12-29 (NCEI Accession 0148770)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NCEI Accession 0148770 includes Surface underway data collected from LAURENCE M. GOULD in the South Atlantic Ocean, South Pacific Ocean and Southern Oceans (> 60...

  17. Partial pressure (or fugacity) of carbon dioxide, salinity and other variables collected from Surface underway observations using Carbon dioxide (CO2) gas analyzer, Shower head chamber equilibrator for autonomous carbon dioxide (CO2) measurement and other instruments from LAURENCE M. GOULD in the South Atlantic Ocean, South Pacific Ocean and Southern Oceans from 2011-12-30 to 2012-12-24 (NCEI Accession 0144349)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NCEI Accession 0144349 includes Surface underway data collected from LAURENCE M. GOULD in the South Atlantic Ocean, South Pacific Ocean and Southern Oceans (> 60...

  18. Partial pressure (or fugacity) of carbon dioxide, salinity and other variables collected from Surface underway observations using Carbon dioxide (CO2) gas analyzer, Shower head chamber equilibrator for autonomous carbon dioxide (CO2) measurement and other instruments from LAURENCE M. GOULD in the South Atlantic Ocean, South Pacific Ocean and Southern Oceans from 2014-12-30 to 2015-07-01 (NCEI Accession 0144343)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NCEI Accession 0144343 includes Surface underway data collected from LAURENCE M. GOULD in the South Atlantic Ocean, South Pacific Ocean and Southern Oceans (> 60...

  19. Partial pressure (or fugacity) of carbon dioxide, salinity and other variables collected from Surface underway observations using Carbon dioxide (CO2) gas analyzer, Shower head chamber equilibrator for autonomous carbon dioxide (CO2) measurement and other instruments from LAURENCE M. GOULD in the South Atlantic Ocean, South Pacific Ocean and Southern Oceans from 2013-12-31 to 2014-12-20 (NCEI Accession 0144532)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NCEI Accession 0144532 includes Surface underway data collected from LAURENCE M. GOULD in the South Atlantic Ocean, South Pacific Ocean and Southern Oceans (> 60...

  20. Frequencies of red blood cell major blood group antigens and phenotypes in the Chinese Han population from Mainland China.

    Science.gov (United States)

    Yu, Y; Ma, C; Sun, X; Guan, X; Zhang, X; Saldanha, J; Chen, L; Wang, D

    2016-08-01

    Alloantibodies directed to red blood cell (RBC) antigens play an important role in alloimmune-mediated haemolytic transfusion reactions and haemolytic disease of the foetus and newborn. The frequencies and phenotypes of RBC antigens are different in populations from different geographic areas and races. However, the data on major blood group antigens in the Chinese Han population from Mainland China are still very limited; thus, we aimed to investigate them in this study. A total of 1412 unrelated voluntary Chinese Han blood donors were randomly recruited. All donors were typed for blood group antigens: D, C, c, E, e, C(w) , Jk(a) , Jk(b) ,M, N, S, s, Le(a) , Le(b) , K, k. Kp(a) , Kp(b) , Fy(a) , Fy(b) , Lu(a) , Lu(b) , P1 and Di(a) using serological technology. Calculations of antigen and phenotype frequencies were expressed as percentages and for allele frequencies under the standard assumption of Hardy-Weinberg equilibrium. Amongst the Rh antigens, D was the most common (98.94%) followed by e (92.28%), C (88.81%), c (58.43%), E (50.78%) and C(w) (0.07%) with DCe/DCe (R1 R1 , 40.72%) being the most common phenotype. In the Kell blood group system, k was present in 100% of the donors and a rare phenotype, Kp (a+b+), was found in 0.28% of the donors. For the Kidd and Duffy blood group systems, Jk (a+b+) and Fy (a+b-) were the most common phenotypes (44.05% and 84.35%, respectively). In the MNS blood group system, M+N+S-s+ (45.54%) was the most common, whereas M+N-S-s- and M-N+S-s- were not found. The rare Lu (a-b-) and Lu (a+b+) phenotypes were identified in 0.43% and 1.13% of the donors, respectively. Le(a) and Le(b) were seen in 17.92% and 63.03% of donors, respectively. The frequency of Di(a) was 4.75%, which was higher than in the Chinese population in Taiwan region or the Caucasian and Black populations (P frequencies of 24 blood group antigens in the Chinese Han population from Mainland China. The data can be helpful in creating a donor database for

  1. The philosophy of Hans-Georg Gadamer / Wolfgang Drechsler

    Index Scriptorium Estoniae

    Drechsler, Wolfgang, 1963-

    1998-01-01

    Rets.rmt.: The philosophy of Hans-Georg Gadamer : a review of the philosophy of Hans-Georg Gadamer / Lewis Edwin Hahn, ed. Chicago and La Salle, IL: Open Court, 1997. (The Library of Living Philosophers, vol. XXIV)

  2. The philosophy of Hans-Georg Gadamer / Wolfgang Drechsler

    Index Scriptorium Estoniae

    Drechsler, Wolfgang, 1963-

    1998-01-01

    Rets.rmt.: The philosophy of Hans-Georg Gadamer : a review of the philosophy of Hans-Georg Gadamer / Lewis Edwin Hahn, ed. Chicago and La Salle, IL: Open Court, 1997. (The Library of Living Philosophers, vol. XXIV)

  3. Hans Kruusi seotusest kodu-uurimisliikumisega / Eva Maaring

    Index Scriptorium Estoniae

    Maaring, Eva

    2011-01-01

    Uks kodu-uurimise valdkonda paotus Hans Kruusile Tartu Õpetajate Seminaris õppides 1910. aastal. 1920. aastatel elavnes Tartus teaduslik kodu-uurimine, hakkasid ilmuma koguteosed. Ajaloolasena oli nendes oma osa H. Kruusil. 1958. aastal sai Hans Kruusist Eesti NSV TA juures tegutseva kodu-uurimise komisjoni esimees. Hans Kruusi tabavaid ütlusi

  4. Rannarootslaste suurmees Hans Pöhl / Olev Liivik

    Index Scriptorium Estoniae

    Liivik, Olev, 1975-

    2011-01-01

    Arvustus: Estlandssvenskarnas hövding. En biografi över Hans Pöhl (1876-1930), estlandssvenskarnas främste företrädare och ledare = Hans Pöhl - rannarootslaste eestvõileja : Hans Pöhl (1876-1930), Eesti rootslaste vaimse liidri ja valgustaja elulugu. Stockholm, 2010

  5. Hans Kolb的实时系统

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    德国家族企业Hans Kolb Wellpappe GmbH&Co.KG公司致力于制造瓦楞设备,多年来,一直使用Kiwiplan公司的生产执行系统(MES)。最近,公司决定将品质检测记录电子化,以提高其运行速度、精准性和操作便利性,便采购了Kiwiplan公司的质量管理系统(QMS)模块。

  6. Tülikas meediademokraat Hans H. Luik / Hans H Luik ; interv. Jaanika Merilo

    Index Scriptorium Estoniae

    Luik, Hans H., 1961-

    2006-01-01

    Ekspress Grupi omanik ja nõukogu liige Hans H. Luik vastab küsimustele, mis puudutavad Ekspress Grupi võimlikku börsile minekut, meediaportfelli laiendamist ning tema vastu suunatuid rünnakuid. Skeem: Ekspress Grupp. Tabelid: Eesti Ekspressi majandusnäitajad; Ekspress Grupi majandusnäitajad. Kommenteerivad: Tuomas Siltala, Karoly Kirber, Lauri Lind ja Peeter Koppel

  7. Profile of Rh, Kell, Duffy, Kidd, and Diego blood group systems among blood donors in the Southwest region of the Paraná state, Southern Brazil.

    Science.gov (United States)

    Zacarias, Joana Maira Valentini; Langer, Ieda Bernadete Volkweis; Visentainer, Jeane Eliete Laguila; Sell, Ana Maria

    2016-12-01

    The aim of this study was to assess the distribution of alleles and genotypes of the blood group systems Rh, Kell, Duffy, Kidd, and Diego in 251 regular blood donors registered in the hemotherapy unit of the Southwestern region of Paraná, Southern Brazil. The frequencies were obtained by direct counting on a spreadsheet program and statistical analyses were conducted in order to compare them with other Brazilian populations using chi-squared with Yates correction on OpenEpi software. The frequencies of RHD* negative, RHCE*c/c and RHCE*e/e were higher than expected for the Caucasian population. A difference was also observed for FY alleles, FY*01/FY*01 genotype and FY*02N.01 -67T/C (GATA Box mutation). Two homozygous individuals were defined as a low frequency phenotype K + k- (KEL*01.01/KEL*01.01) and, for Diego blood group system the rare DI*01 allele was found in ten blood donors, of which one was DI*01/DI* 01 (0.4%). The allele and genotype frequencies of Kidd blood group system were similar to expected to Caucasians. The results showed the direction in which to choose donors, the importance of extended genotyping in adequate blood screening and the existence of rare genotypes in Brazilian regular blood donors. Copyright © 2016 Elsevier Ltd. All rights reserved.

  8. 劳伦斯作品中人与自然和谐关系的探析%Analysis of harmonious relationship between man and nature in Laurence's major works

    Institute of Scientific and Technical Information of China (English)

    张敬

    2014-01-01

    Facing the predicament of human beings brought by First World War and the industrial civilization , Laurence put forward to set up the harmonious relationship between man and nature to help human beings find a way out .This arti-cle is to analyze his harmonious concept between man and nature based on Laurence 's three major works Rainbow, Women in Love and Lady Chatterley’ s Lover.%面对第一次世界大战与工业文明给人类所带来的困境,劳伦斯提出通过建立人与自然的和谐关系,帮助人类找寻出路。本文从劳伦斯的三部主要作品《虹》、《恋爱中的女人》和《查泰来夫人的情人》中分析其倡导人与自然和谐的思想。

  9. Nursing care of a child with Laurence-Moon-Biedl syndrome complicated by type 2 diabetes%劳-蒙-毕综合征伴2型糖尿病患儿的护理

    Institute of Scientific and Technical Information of China (English)

    郑燕

    2013-01-01

    总结1例劳-蒙-毕综合征(Laurence-Moon-Biedl syndrome)伴2型糖尿病患儿的护理.护理要点包括:密切监测血糖及使用胰岛素、加强饮食管理、合理运动、心理支持、安全护理、健康教育.该惠儿住院期间配合治疗,家长学会正确监测血糖、使用胰岛素、掌握疾病相关知识,住院9d后患儿血糖控制后平稳出院.%This paper summarizes the nursing care of a patient with Laurence-Moon-Biedl syndrome complicated by type 2 diabetes.The key points were close monitoring of blood glucose and insulin injection,strengthening diet management,exercise,psychological support,safety nursing and health education.The child cooperated with the treatment well during hospitalization and the parents learned how to correctly monitor blood glucose and inject insulin and mastered diabetes related knowledge.The child was discharged from the hospital with stable blood glucose after 9 days.

  10. Dahiri, Mohammed; Carmelo García, Juan; González, Santiago; Lozano, Carlos; Otega, Alejandra y Thieux, Laurence (eds., Sociedad civil y transiciones en el norte de África. Egipto, Túnez, Argelia, Marruecos. Barcelona, Icaria Editorial, 2013, 250 pp.

    Directory of Open Access Journals (Sweden)

    Antonio Javier Martín Castellanos

    2014-10-01

    Full Text Available Dahiri, Mohammed; Carmelo García, Juan; González, Santiago; Lozano, Carlos; Otega, Alejandra y Thieux, Laurence (eds., Sociedad civil y transiciones en el norte de África. Egipto, Túnez, Argelia, Marruecos. Barcelona, Icaria Editorial, 2013, 250 pp.

  11. Brad Mehldau : Analytiske perspektiver på hans spillestil

    OpenAIRE

    2012-01-01

    Brad Mehldau (f. 1970) må kunne sies å være en av de store nålevende jazzpianistene, og han har gjort seg vel bemerket i både hans hjemland USA og internasjonalt. Han har samarbeidet med kjente utøvere som Pat Metheny, Joshua Redman, Kurt Rosenwinkel, Charlie Haden, Lee Konitz, etc. I sin egen trio, med bassist Larry Grenadier og trommeslager Jeff Ballard, spiller Mehldau en blanding av jazzstandardlåter, egne komposisjoner og poplåter i hans egne arrangementer. Denne oppgaven er sentrert run...

  12. Mathematics Ab Ovo: Hans Driesch and Entwicklungsmechanik.

    Science.gov (United States)

    Priven, Silvia Waisse; Alfonso-Goldfarb, Ana M

    2009-01-01

    One of the factors leading to the creation of embryology as a modern discipline at the end of the 19th century was Wilhelm Roux's formulation of the program of Entwicklungsmechanik (developmental mechanics). A look into the work of Hans Driesch, an equal contributor to developmental mechanics, may shed further light on this process. For Roux, developmental mechanics was an anatomical science, but for Driesch it was associated with a mathematical and physical approach to the natural world. Likewise, Roux used the concept of mechanics as an analogy, but Driesch used it literally. Driesch's generation had been trained in a pedagogic context that emphasized mathematics and physics, which may explain why he went a step further than Roux to state that a true "mechanics" of development required the reduction of morphogenetic problems to the known laws of physics. It is argued here that this difference in background is behind the enthusiastic adoption and further development of Roux's program by Driesch's generation, a generation that conceived Entwicklungsmechanik to be the reduction of embryological processes to "the laws of matter in motion." This same mathematical and physical mindset would underscore Driesch's later construction of entelechy as a regulating factor in embryogenesis, through mathematical analysis grounded on the notion of mathematical functions.

  13. [Hans Jonas: Nature Conservation, Conservation of Life].

    Science.gov (United States)

    Burgui Burgui, Mario

    2015-01-01

    This article discusses three of the problems that the German philosopher Hans Jonas studied. The first one addresses the need for a specific ethic dedicated to the moral dimension of environmental problems, from a different perspective to the traditional. The second problem is crucial in the discussion on environmental ethics: the value of the nature. Does the nature have an intrinsic value or an instrumental value only (to satisfy the interests of the human being)? The thesis of Jonas, which claimed that nature is a good in itself, were further elaborated here. And the third problem is the derivation of moral norms and the role of man in this ethic that recognizes a good in itself in nature. According to Jonas, the human being is not diminished by recognizing the intrinsic value of nature, since the man's uniqueness and value are unquestionable. From these three central issues, the paper highlights the importance of seeking the links between bioethics and environmental ethics to address the current environmental, social and economic crisis.

  14. Obituary: Hans Albrecht Bethe, 1906-2005

    Science.gov (United States)

    Wijers, Ralph

    2007-12-01

    One of the unquestioned giants of physics and astrophysics, Hans Bethe, died on 6 March 2005, at the venerable age of 98, in his home town of Ithaca, New York. Seven decades of contributing to research and a Nobel Prize for his work on stellar hydrogen burning make a listing of his honors superfluous (besides being impossible in this space). Bethe was born in Strassburg, in then German Alsass Lothringen, on 2 July 1906. His father, Albrecht Julius Bethe (1872-1954), taught physiology at the University, and his mother, Anna Kuhn (1876-1966), was a musician and writer. Both his grandfathers were physicians. He spent his youth in Strassburg, Kiel, and Frankfurt, and some time in sanatoria due to tuberculosis. Hans's first scientific paper, at age 18, was with his father and a colleague, on dialysis. His education and early career in Germany brought him into contact with many top stars in the quantum revolution. Starting in Frankfurt in chemistry, Bethe soon switched to physics, taught there by Walter Gerlach and Karl Meissner, among others. In 1926, he successfully applied to join Arnold Sommerfeld's group in Munich, where he met one of his later long-term collaborators, Rudolf Peierls. Bethe considered his entry into physics to have come at an ideal time, with the new ideas of wave mechanics being developed and discussed right there; it was certainly also at an ideal place. His doctoral thesis was on the theory of electron diffraction by crystals, following the experimental work by Clinton Davisson and Lester Germer and the work on X-ray diffraction by Max von Laue and Paul Ewald. The newly minted doctor went from there briefly to Frankfurt and then to Ewald in Stuttgart, where he felt at home academically and personally. In 1939, Bethe would marry Ewald's daughter Rose. Not much later, though, Sommerfeld recalled him to Munich, where Sommerfeld created a Privatdozent position for him. There he worked out the solution for a linear chain of coupled spins by what we

  15. Hans-Georg Gadamer, Language, and Intercultural Communication.

    Science.gov (United States)

    Roy, Abhik; Starosta, William J.

    2001-01-01

    Shows how Hans-Georg Gadamer's critical hermeneutics can be applied to intercultural communication. Suggests that by incorporating the philosophies of Hans-Georg Gadamer, intercultural communication scholars will be able to bring a fresh perspective to guide their theory, research, and practice. (Author/VWL)

  16. Hans Henriksen Ussing. 30 December 1911 - 22 December 2000

    DEFF Research Database (Denmark)

    Larsen, Erik Hviid

    2009-01-01

    Hans Ussing was born on 30 December 1911 at Sorø Academy in Denmark, where his father Dr Henrik Ussing was a lecturer and, as historian, a leading Danish folklorist. After his doctoral thesis in marine biology, Hans Ussing came to August Krogh's laboratory, where he studied protein turnover by us...

  17. Hans-Georg Gadamer, Language, and Intercultural Communication.

    Science.gov (United States)

    Roy, Abhik; Starosta, William J.

    2001-01-01

    Shows how Hans-Georg Gadamer's critical hermeneutics can be applied to intercultural communication. Suggests that by incorporating the philosophies of Hans-Georg Gadamer, intercultural communication scholars will be able to bring a fresh perspective to guide their theory, research, and practice. (Author/VWL)

  18. 上海地区汉族人群红细胞稀有血型系统抗原基因的多态性研究%Research of Genetic Polymorphism of Rare Blood Group System in Shanghai Han Population

    Institute of Scientific and Technical Information of China (English)

    赵晓明; 李志强

    2009-01-01

    目的 研究上海地区汉族临床输血人群8个红细胞稀有血型系统19种抗原基因多态性分布,提高配合性输注的能力.方法 应用PCR-SSP方法进行血型抗原基因分型.结果 Diego,Dombrock,Duffy血型系统抗原基因频率分别为:Dia=0.035 1,Dib=0.964 9;Doa=0.061 4,Dob=0.938 6;Fya=0.964 9,Fyb=0.035 1,Fy=0;均具有多态性.而Kell,Yt,Scianna,L-W,Colton血型系统抗原基因频率分布为单态性.经χ2检验,均符合Hardy-weinberg遗传定律.结论 上海地区汉族临床输血人群Diego、Dombrock、Duffy血型系统抗原基因频率具有多态性,随机临床输血抗原不合率分别是0.065 4、0.108 6、0.065 4,应引起高度重视.%Objective To investigate the polymorphism of 19 antigens of 8 rare red blood group systems in Shanghai clinical transfusion Han population in order to improve the capability of compatible infusion and reduce the transfusion reactions. Methods The genotypes were performed by polymerase chain reaction using sequence-specific primer(PCR-SSP).Results The gene frequencies of Diego,Dombrock,Duffy rare red blood group systems were Dia=0.035 1,Dib=0.964 9;Doa=0.061 4,Dob=0.938 6;Fya=0.964 9,Fyb=0.035 1,Fy=0;while the Kell,Yt,Scianna,L-W,Colton rare red blood groups allele frequencies distribution is monomorphic. There was a good fit to Hardy-weinberg equilibrium within each group.Conclusion There are great differences among the Diego,Dombrock,Duffy blood group gene frequencies in shanghai Han population.The rate of antigen mismatches in randomized clinical blood transfusion was 0.065 4,0.108 6,0.065 4 respectively.

  19. Hans Kelsen: pensador político

    Directory of Open Access Journals (Sweden)

    Sara Lagi

    2011-01-01

    Full Text Available Hasta la publicación de Sobre la esencia y el valor de la democracia, Hans Kelsen era solo conocido como experto en derecho público. El valor de este artículo de Lagi radica en rescatar de la obra kelseniana un aspecto casi por completo olvidado por la crítica, a saber, sus análisis sobre el significado y las características de la democracia parlamentaria en los Estados modernos. Se aborda la cuestión no solo desde el debate teórico sino también desde su contexto histórico¿político. La teoría política de Kelsen es considerada una parte integral de su doctrina central, presentada en Teoría pura del derecho, su obra más conspicua. Un análisis del trabajo sobre la esencia y el valor de la democracia nos restituye la imagen de un Kelsen como original pensador político. Se analizan las dos ediciones de Sobre la esencia y el valor de la democracia (1920¿1929 con estos propósitos: comprender por qué decidió dedicarse a la teoría de la democracia un teórico que rigurosamente defendió la separación de la esfera jurídica respecto de la historia, la filosofía y la política; y por qué no se limitó a explicar la esencia de la democracia sino que decidió concentrarse en clarificar qué se entiende por valor de la democracia.

  20. Method for Observing Intravascular BongHan Duct

    CERN Document Server

    Jiang, X; Shin, H; Lee, B; Choi, C; Soh, K; Cheun, B; Baik, K; Soh, K; Jiang, Xiaowen; Kim, Hee-kyeong; Shin, Hak-soo; Lee, Byong-chon; Choi, Chunho; Soh, Kyung-soon; Cheun, Byeung-soo; Baik, Ku-youn; Soh, Kwang-sup

    2002-01-01

    A method for observing intra blood vessel ducts which are threadlike bundle of tubules which form a part of the BongHan duct system. By injecting 10% dextrose solution at a vena femoralis one makes the intravascular BongHan duct thicker and stronger to be easily detectable after incision of vessels. The duct is semi-transparent, soft and elastic, and composed of smaller tubules whose diameters are of 10$\\mu$m order, which is in agreement with BongHan theory.

  1. Altofrequency SNPs of mitochondrial DNA in 26 Han Chinese

    Institute of Scientific and Technical Information of China (English)

    LUO Yong-jun; GAO Wen-xiang; GAO Yu-qi; CHEN Jian; TAN Xiao-ling; LIU Xin; CHEN Hai-hua

    2007-01-01

    Objective:To explore the possible mitochondrial DNA (mtDNA) polymorphism in Han Chinese.Methods:The complete mitochondrial genome of 26 unrelated healthy Han Chinese were extracted and sequenced.Results:The mtDNA nucleotide sites (2 706,7 028,8 860,11 719,and 15 326)were found totally different from the Revised Cambridge Reference Sequence (rCRS).These single nucleotide polymorphisms (SNPs) were 2 706 A→G,7 028 C→T,8 860 A→G,11 719 G→A,15 326 A→G.Conclusion:These findings provide new insights into the characteristics of Han Chinese mitochondrial genetic diversity.

  2. Sénécal Gilles, Bherer Laurence (dir., 2009, La métropolisation et ses territoires, Presses universitaires du Québec, 320 p.

    Directory of Open Access Journals (Sweden)

    Solange Verger

    2009-10-01

    Full Text Available L’ouvrage dirigé par Gilles Sénécal et Laurence Bherer reprend le thème désormais classique de la « métropolisation ». Il s’agit donc de parler de la ville, ou plus précisément, des changements à l’œuvre dans les grandes villes depuis plus d’une trentaine d’années. C’est donc sans surprise que la plupart des auteurs réunis dans cet ouvrage collectif appartiennent à des centres de recherche ayant fait des études urbaines leur thématique principale. Pourtant, le titre « La métropolisation et se...

  3. Profanum et Promissio : het begrip wereld in de missionaire ecclesiologieën van Hans Hoekendijk, Hans Jochen Margull en Ernst Lange

    NARCIS (Netherlands)

    Petter, Frank Anthonie

    2002-01-01

    Profanum et Promissio The concept of ‘world’ in the missionary ecclesiologies of Hans Hoekendijk, Hans Jochen Margull and Ernst Lange. This study deals with the concept of ‘world’ in the missionary ecclesiologies of Hans Hoekendijk (1912-1975), Hans Jochen Margull (1925-1982) and Ernst Lange (1927-1

  4. Profanum et Promissio : het begrip wereld in de missionaire ecclesiologieën van Hans Hoekendijk, Hans Jochen Margull en Ernst Lange

    NARCIS (Netherlands)

    Petter, Frank Anthonie

    2002-01-01

    Profanum et Promissio The concept of ‘world’ in the missionary ecclesiologies of Hans Hoekendijk, Hans Jochen Margull and Ernst Lange. This study deals with the concept of ‘world’ in the missionary ecclesiologies of Hans Hoekendijk (1912-1975), Hans Jochen Margull (1925-1982) and Ernst Lange

  5. Profanum et Promissio : het begrip wereld in de missionaire ecclesiologieën van Hans Hoekendijk, Hans Jochen Margull en Ernst Lange

    NARCIS (Netherlands)

    Petter, Frank Anthonie

    2002-01-01

    Profanum et Promissio The concept of ‘world’ in the missionary ecclesiologies of Hans Hoekendijk, Hans Jochen Margull and Ernst Lange. This study deals with the concept of ‘world’ in the missionary ecclesiologies of Hans Hoekendijk (1912-1975), Hans Jochen Margull (1925-1982) and Ernst Lange (1927-1

  6. Phenotype frequencies of blood group systems (Rh, Kell, Kidd, Duffy, MNS, P, Lewis, and Lutheran in blood donors of south Gujarat, India

    Directory of Open Access Journals (Sweden)

    Manoj A Kahar

    2014-01-01

    Full Text Available Background: This is the first study on phenotype frequencies of various blood group systems in blood donors of south Gujarat, India using conventional tube technique. Material and Methods: A total of 115 "O" blood group donors from three different blood banks of south Gujarat were typed for D, C, c, E, e, K, Jk a , Le a , Le b , P 1 , M, and N antigens using monoclonal antisera and k, Kp a , Kp b , Fy a ,Fy b , Jk b , S,s, Lu a , and Lu b antigens were typed using polyclonal antisera employing Indirect Antiglobulin Test. Antigens and phenotype frequencies were expressed as percentages. Results: From the 115 blood donor samples used for extended antigen typing in the Rh system, e antigen was found in 100% donors, followed by D [84.35%], C [81.74%], c [56.32%], and E [21.74%] with DCe/DCe (R 1 R 1 , 40.87% as the most common phenotype. k was found to be positive in 100% of donors and no K+k- phenotype was found in Kell system. For Kidd and Duffy blood group system, Jk(a+b+ and Fy(a-b- were the most common phenotypes with frequency of 52.17% and 48.69%, respectively. In the MNS system, 39.13% donors were typed as M+N+, 37.39% as M+N-, and 23.48% as M-N+. S+s+ was found in 24.35% of donors, S+s- in 8.69%, and S-s+ as the commonest amongst donors with 66.96%. No Lu(a+b+ or Lu(a+b- phenotypes were detected in 115 donors typed for Lutheran antigens. A rare Lu(a-b- phenotype was found in 2.61% donors. Conclusion: Data base for antigen frequency of various blood group systems in local donors help provide antigen negative compatible blood units to patients with multiple antibodies in order to formulate in-house red cells for antibody detection and identification and for preparing donor registry for rare blood groups.

  7. Estlandse uithaal naar oud-ambassadeur / Hans Jacobs

    Index Scriptorium Estoniae

    Jacobs, Hans

    2008-01-01

    Hollandi ajakirjanikud küsisid president Toomas Hendrik Ilveselt arvamust endise Hollandi suursaadiku Hans Glaubitzi tagakiusamise kohta. Eestis visiidil olnud Hollandi kuninganna Beatrix'i ja president Toomas Hendrik Ilvese kohtumisest

  8. Estlandse uithaal naar oud-ambassadeur / Hans Jacobs

    Index Scriptorium Estoniae

    Jacobs, Hans

    2008-01-01

    Hollandi ajakirjanikud küsisid president Toomas Hendrik Ilveselt arvamust endise Hollandi suursaadiku Hans Glaubitzi tagakiusamise kohta. Eestis visiidil olnud Hollandi kuninganna Beatrix'i ja president Toomas Hendrik Ilvese kohtumisest

  9. Interview with Hans Rott, January 2014, CAUS History

    OpenAIRE

    Rott, Hans

    2014-01-01

    Interview with Hans Rott, Professor of Architecture, on the history of Virginia Tech's College of Architecture and Urban Studies, his experiences with students and teaching, and his perspective on the importance and meaning of architecture.

  10. September 2013 DMM Podcast: an interview with Hans Clevers

    Science.gov (United States)

    2013-01-01

    SUMMARY An interview with Hans Clevers, Professor of Molecular Genetics at Utrecht University, in which he discusses his transition into applied science, the story behind his key findings in the stem cell and cancer fields, and the potential of organoid-based therapy for personalised medicine. Hans was interviewed by Ross Cagan, DMM Editor-in-Chief. The podcast is narrated by Paraminder Dhillon. To listen to this podcast, visit http://www.biologists.com/DMM/podcasts/index.html.

  11. Children and Moods in Hans Christian Andersen's Travel Books

    DEFF Research Database (Denmark)

    Jensen, Lars Bo

    2008-01-01

    A categorization of moods, atmospheres and motifs connected with the children in Hans Christian Andersen’s five travel books (1831-1868). Surprisingly, death and darkness and, on the other side, eroticism and (red) light are the dominant two categories.......A categorization of moods, atmospheres and motifs connected with the children in Hans Christian Andersen’s five travel books (1831-1868). Surprisingly, death and darkness and, on the other side, eroticism and (red) light are the dominant two categories....

  12. In memoriam Hans Jürgen Eysenck (1916-1997)

    OpenAIRE

    Andrés Pueyo, Antonio

    1997-01-01

    El pasado día 4 de septiembre moría en Londres Hans Jürgen Eysenck, víctima de una rápida enfermedad que ha hecho desaparecer a una de las más grandes figuras de la psicología contemporánea.Hans Eysenck vivió en 'un tiempo muy interesante', como él mismo ha considerado en su autobiografía.

  13. Suve suurim lustipidu / Laurence Lumiere

    Index Scriptorium Estoniae

    Lumiere, Laurence

    2008-01-01

    ABBA muusikale loodud muusikafilm "Mamma Mia!" : lavastaja Phyllida Lloyd : produtsent Judy Craymer : naispeaosas Meryl Streep : Suurbritannia - Ameerika Ühendriigid 2008. Filmi saamisloost. Lisatud nimekirjad "Maailma paremad muusikalid" ja "10 edukamat muusikali Põhja-Ameerika kinodes"

  14. Bond, uus Bond / Laurence Lumiere

    Index Scriptorium Estoniae

    Lumiere, Laurence

    2006-01-01

    Uus Bondi-film "007: Casino Royale". Stsenaristid Ian Flemingi raamatu ainetel Neal Purvis, Robert Wade, Paul Haggis. Režissöör Martin Campbell, peaosas Daniel Craig - Ameerika Ühendriigid-Suurbritannia 2006

  15. Bond, uus Bond / Laurence Lumiere

    Index Scriptorium Estoniae

    Lumiere, Laurence

    2006-01-01

    Uus Bondi-film "007: Casino Royale". Stsenaristid Ian Flemingi raamatu ainetel Neal Purvis, Robert Wade, Paul Haggis. Režissöör Martin Campbell, peaosas Daniel Craig - Ameerika Ühendriigid-Suurbritannia 2006

  16. Elust suurem seiklus / Laurence Lumiere

    Index Scriptorium Estoniae

    Lumiere, Laurence

    2002-01-01

    Peter Jacksoni esimene film J.R.R. Tolkieni triloogia "Sõrmuste isand" alusel - "Sõrmuse vennaskond", "The Lord of the Rings : The Fellowship of the Ring" : Uus-Meremaa, Ameerika Ühendriigid 2001. Ka : Teleleht nr. 3, lk. 43

  17. Home Energy Management System Using NILM, Low-Cost HAN

    Institute of Scientific and Technical Information of China (English)

    Qasim Khalid; Naveed Arshad; Nasir Khan; Taha Hassan; Fahad Javed; Jahangir Ikram

    2014-01-01

    Home energy management systems (HEMs) are used to provide comfortable life for consumers as well as to save energy. An essential component of HEMs is a home area network (HAN) that is used to remotely control the electric devices at homes and buildings. Although HAN prices have dropped in recent years but they are still expensive enough to prohibit a mass scale deployments. In this paper, a very low cost alternative to the expensive HANs is presented. We have applied a combination of non-intrusive load monitoring (NILM) and very low cost one-way HAN to develop a HEM. By using NILM and machine learning algorithms we find the status of devices and their energy consumption from a central meter and communicate with devices through the one-way HAN. The evaluations show that the proposed machine learning algorithm for NILM achieves up to 99%accuracy in certain cases. On the other hand our radio frequency (RF)-based one-way HAN achieves a range of 80 feet in all settings.

  18. Postoperative comparison of result of renal transplantation between ethnic minorities and Han recipients after receiving kidneys from Han donors

    Directory of Open Access Journals (Sweden)

    Han-wen CUI

    2013-04-01

    Full Text Available Objective  To analyze the outcomes and postoperative complications of renal transplant recipients of ethnic minorities and Han population in China, and investigate the differences between them. Methods  Clinical data from 89 minorit y patients and 100 Han patients who had received renal transplant of Hans' donators in Organ Transplantation Center of PLA from 1990 to 2012 were retrospectively analyzed. The general data before transplantation, and rate of short-term survival of the graft, incidence of delayed graft function (DGF, acute rejection, and pulmonary infection after transplantation were analyzed and compared. Results  No statistical difference was found in the preoperative personal profile between the recipients of minorities and Han nationality. In the recipients of minorities and Han nationality, the 1-year graft survival rate was 89.9% and 92%, the respective incidence of DGF was 28.1% and 27.0%, and the respective incidence of acute rejection was 22.5% and 19.0%, and there was no significant difference between them (P>0.05. The incidence of pulmonary infection was higher in minority recipients (30.3% than in Han recipients (10.0%, P0.05. Conclusion  The short-term clinical outcome of renal transplant recipients seems to be similar in different Chinese ethnic groups, but the incidence of pulmonary infection is higher in minority recipients, so it is important to strengthen monitoring in early postoperative period.

  19. "Reinhart Koselleck / Hans-Georg Gadamer (Hrsg.): Historik, Sprache und Hermeneutik – Eine Rede und eine Antwort. Herausgegeben zum 100. Geburtstag von Hans-Georg Gadamer. Mit einem Nachwort von Hans-Peter Schütt."

    OpenAIRE

    2001-01-01

    Besprechung "Reinhart Koselleck / Hans-Georg Gadamer (Hrsg.): Historik, Sprache und Hermeneutik – Eine Rede und eine Antwort. Herausgegeben zum 100. Geburtstag von Hans-Georg Gadamer. Mit einem Nachwort von Hans-Peter Schütt."

  20. Evelini lugu. Kelle heaks? Kelle aeg? Kelle raha? / Külli-Riin Tigasson

    Index Scriptorium Estoniae

    Tigasson, Külli-Riin, 1975-

    2008-01-01

    Eesti Päevalehe tellitud ja Faktum & Ariko tehtud arvamusuuringus esitati küsimus: "Kas presidendiproua Evelin Ilves on tulnud riigi esimese leedi funktsiooniga väärikalt toime?" Uuringu tulemused diagrammi kujul 2007. ja 2008. a. kohta. Arvamust avaldavad kunstnik Piret Räni, sotsioloog Airi-Alina Allaste, treener Marek Morozov, spordisotsioloog Joe Noormets, reklaamiuurija Merit Karise

  1. Thermoluminescence authentication of T`ang and Han Dynasty pottery

    Energy Technology Data Exchange (ETDEWEB)

    Price, D.M. [Wollongong Univ., NSW (Australia). School of Geosciences

    1997-12-31

    More than 80 pieces of T`ang Dynasty and 40 Han Dynasty style ceramic wares have been analysed to determine the amount of thermoluminescence (TL) accumulated since the initial firing of the object and the level of the radiation flux which has created the TL. This paper presents a summary of the thermoluminescence analysis results. Approximately 60% of Han ceramics and 45% of the T`ang pottery authenticated have been shown to belong to periods other than that stylistically suggested. Items which have been found not to be of the anticipated antiquity generally fall into distinct age groups. Of the T`ang wares the most commonly copied item is found to be the horse and for the Han pieces, human figures and ewers/pots/vases represent the most frequently reproduced wares.

  2. PENERAPAN TEORI HANS KELSEN DALAM TERTIB HUKUM INDONESIA

    Directory of Open Access Journals (Sweden)

    Muhtadi Muhtadi

    2014-03-01

    Full Text Available Tujuan penelitian ini adalah untuk mengetahui bagaimana pengaturan susunan dan tertib hukum Indonesia dalam hirarki norma berdasarkan Stufenbautheorie Hans Kelsen. Metode penelitian yang digunakan adalah doctrinal research dengan menggunakan data sekunder yang diperoleh melalui studi pustaka. Hasil penelitian menunjukkan bahwa pilihan hukum susunan norma hukum Indonesia berdasarkan teori Hans Kelsen adalah berjenjang dan berlapis-lapis, dari norma hukum lapisan terendah yang operatif-konkret-individual berjenjang dan bersumber pada norma hukum general-abstract berpuncak dalam pandangan dan cita hukum yang menjadi staatsnorm atau staatsfundamentalnorm, yaitu berpuncak pada Pancasila sebagai cita hukum.

  3. Talk about Han eaves tile art in our country

    Institute of Scientific and Technical Information of China (English)

    刘泽艺

    2015-01-01

    The Han Dynasty is the first in the history of the unified and powerful country. It is a huge momentum has also affected the development of art, especially the art of eaves tile. Pattern of Han eaves tile is the art of the Chinese nation in the classic, rich artistic value for tile study of traditional ceramic art is very necessary in China. Through the research on Eave Tile Art, can be in-jected into the power of ceramic art in China's new development.

  4. Language, Literacy, and Nationalism: Taiwan's Orthographic Transition from the Perspective of Han Sphere

    Science.gov (United States)

    Chiung, Wi-vun Taiffalo

    2007-01-01

    The Han sphere, including Vietnam, Korea, Japan, Taiwan and China, adopted Han characters and classical Han writing as the official written language before the 20th century. However, great changes came with the advent of the 20th century. After World War II, Han characters in Vietnam and Korea were officially replaced by the romanised "Chu…

  5. ["Snow" and "Walpurgisnacht". Hans Castorp's exemplary maturation crises in "Zauberberg"].

    Science.gov (United States)

    Heinrich, K; Walter, C

    1995-01-01

    On the occasion of a rather incidental visit in the sanatorium "Berghof" at Davos, Hans Castorp, the--as to his primary personality--asthenic and low-profile protagonist of the "Zauberberg" is gradually getting caught up in the maelstrom of the there prevailing timelessness and irresponsibility, this being interrupted solely by two tapering to crisis episodes: his amouressness to Mme. Chauchat as an erotic crisis and by the visionary daydream during a snowstorm about the abilities of men as a cognitive, mental crisis. Both events are triggered by a pathoid irritability, following the maxim of Th. Mann that illness, decay and death as borderline experiences may be the presupposition for cognition and reversal. Both crises end without consequences--the "Zauberberg" is the negation of the novel of education and development in the narrower sense. The unsuccessfulness and undecidedness of Hans Castorp's existence culminate in the open end of the novel, regarding his surviving on the battle field, and is in strict contrast to Adrian Leverkühn's determined autoinfection with Lues with the aim of artistic perfection and the creative break-through of "Doctor Faustus". Hans Castorp's regression and self-fragmentation within the decadent-morbid atmosphere of the sanatorium lead to his storming into the battles of the First World War as a last and existential crisis; it is here where finally the individual and national fate are merging. Hans Castorp becomes the paradigma of the German pre-war bourgeoisie and its crisis-prone development.

  6. Hans Christian Ørsted : natuurwetenschapper als estheticus

    NARCIS (Netherlands)

    Millekamp, Jan

    2012-01-01

    The Danish scientist Hans Christian Ørsted (1777-1851) is most famous for his discovery of electromagnetism, a discovery that literally and irreversibly changed our world. In Denmark he is also known as a poet and essayist. Interestingly, his scientific and his aesthetic work are closely interrelate

  7. Steve Jobs, Ameerika Hans H. Luik / Kertu Ruus

    Index Scriptorium Estoniae

    Ruus, Kertu, 1977-

    2007-01-01

    Autor võrdleb Apple'i asutajat ja juhti Steve Jobsi Eesti meediaärimehe Hans H. Luigega. Vt. samas: Jobs: ärge raisake aega teiste elu elamisele; Forbes: iPhone'ist saab Apple'i suur hitt; CV: Steven Paul Jobs. Diagramm: Apple'i aktsia

  8. Our Hitler - A Film by Hans-Jürgen Syberberg

    NARCIS (Netherlands)

    Elsaesser, T.; Machtans, K.; Ruehl, M.A.

    2012-01-01

    A good deal of the interest aroused by the so-called New German Cinema in the 1970s and 1980s was generated by the impression - as well as the expectation - that the films of Werner Herzog, Rainer Werner Fassbinder, Hans-Jürgen Syberberg, Wim Wenders, and others were not just another European new wa

  9. Homage to Professor Hans-Åke Gustafsson

    CERN Multimedia

    2010-01-01

    It was with deep sadness that we learned of the death of Professor Hans-Åke Gustafsson, an internationally recognized scientist, beloved colleague and friend. He passed away on Wednesday January 13th at the Lund University Hospital, surrounded by his loved ones, after a short battle against cancer. This is a great loss for all of us in ALICE and the whole heavy ion community. Hans-Åke, Professor at Lund University, was one of the pioneers of heavy ion physics with relativistic beams since its very beginning. He started his research at CERN, as a fellow at the ISOLDE ion beam facility, and immediately after, in the early 1980 joined the Plastic Ball collaboration at the Bevalac. One of the seminal papers of the field on the discovery of collective flow in relativistic nuclear collisions, co-authored by Hans-Åke, Hans Gutbrod and colleagues, stems from this period. From that point on he was always at the forefront of research with relativistic nuclear beams, being for three de...

  10. President Hans Ager of Austrian Federal Council Visits China

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    <正>An Austrian goodwill delegation led by Hans . Ager, president of the Austrian Federal Coun-cil and board member of the Austrian Association for Promotion of Friendship and Cultural Relations with China (AAPFCRC), paid a friendly visit to China in November, 2003 at the invitation of the CPAFFC. On the delegation were Dietmar Bachmann, president of the Industrial Federation of

  11. Steve Jobs, Ameerika Hans H. Luik / Kertu Ruus

    Index Scriptorium Estoniae

    Ruus, Kertu, 1977-

    2007-01-01

    Autor võrdleb Apple'i asutajat ja juhti Steve Jobsi Eesti meediaärimehe Hans H. Luigega. Vt. samas: Jobs: ärge raisake aega teiste elu elamisele; Forbes: iPhone'ist saab Apple'i suur hitt; CV: Steven Paul Jobs. Diagramm: Apple'i aktsia

  12. Combustion of Han-Based Monopropellant Droplets in Reduced Gravity

    Science.gov (United States)

    Shaw, B. D.

    1999-01-01

    The objective of this research is to study combustion of monopropellant droplets and monopropellant droplet components in reduced-gravity environments so that spherical symmetry is strongly promoted. The experiments will use hydroxylammonium nitrate (HAN, chemical formula NH3OHNO3) based monopropellants. This class of monopropellant is selected for study because of its current relevance and also because it is relatively benign and safe to work with. The experimental studies will allow for accurate determination of fundamental data on deflagration rates, gas-phase temperature profiles, transient gas-phase flame behaviors, the onset of bubbling in droplets at lower pressures, and the low-pressure deflagration limit. The theoretical studies will provide rational models of deflagration mechanisms of HAN-based liquid propellants. Besides advancing fundamental knowledge, the proposed research should aid in applications (e.g., spacecraft thrusters and liquid propellant guns) of this unique class of monopropellants.

  13. Hans Christian Ørsted reading nature's mind

    CERN Document Server

    Christensen, Dan Charly

    2013-01-01

    Hans Christian Orsted (1777-1851) is of great importance as a scientist and philosopher far beyond the borders of Denmark and his own time. At the centre of an international network of scholars, he was instrumental in founding the world picture of modern physics. Orsted was the physicist who brought Kant's metaphysics to fruition. In 1820 his discovery of electro-magnetism, a phenomenon that could not possibly exist according to his adversaries, changed the course of research in physics. It inspired Michael Faraday's experiments and discovery of the adverse effect, magneto-electric induction. The two physical phenomena were later described in mathematical equations by J.C. Maxwell. Together these discoveries constitute the prerequisites for the overwhelming development of modern technology. But Orsted was also one of the cultural leaders and organizers of the Danish Golden Age (together with Grundtvig, Kierkegaard, and Hans-Christian Andersen, his protege), and made significant contributions to aesthetics, ph...

  14. Hans von Hattingberg (1879-1944) Leben und Werk

    OpenAIRE

    Keifenheim, Katharina Eva

    2011-01-01

    Hans von Hattingberg, geboren am 18.11.1879 in Wien, wird heute vor allem mit dem Deutschen Institut für Psychologische Forschung und Psychotherapie („Göring-Institut“) in Verbindung gebracht, wo er sich mit der „Neuen Deutschen Seelenheilkunde“ und der Erarbeitung von „Thesen zur Neurosenlehre“ befasste. Interessanterweise war Hattingberg bis 1932 eher eine Randfigur in der Psychotherapeutenszene und galt vielen als unbelehrbarer Querulant. Viele seiner Arbeiten wurden nie veröffentlicht, u...

  15. Hans Woller, Mussolini. Der erste Faschist. Eine Biographie

    OpenAIRE

    Salvador, Alessandro

    2017-01-01

    La vita di Benito Mussolini, il fascismo e la Seconda guerra mondiale occupano una posizione ancora scomoda nella memoria storica italiana. È un po’ questo il pensiero dominante della biografia realizzata da Hans Woller. La stessa definizione di biografia, per questo volume, è decisamente riduttiva. Attraverso undici date e luoghi chiave della storia di Mussolini e del fascismo, Woller riesce in un’impresa non semplice: sintetizzare il più recente e completo stato della ricerca su quel period...

  16. CROSS SECTIONAL STUDY OF NUTRITIONAL STATUS IN OLDER HAN WOMEN.

    Science.gov (United States)

    Jun, Tao; Yuan, Zhong

    2016-01-01

    Abstract. Malnutrition is one of the most prevalent problems in older people, but there is little information about the nutritional status of the older women in China. Therefore, this study was conducted to investigate the nutritional status and clinically correlated factors for malnutrition in older Han women in China. In total, 2,556 hospital- and community-based Han women aged 60 years or older were recruited between May 2007 and December 2014. All women completed comprehensive geriatric assessment, and the Mini Nutritional Assessment Short Form (MNA-SF) was used to assess the nutritional status. The clinically corre- lated factors for malnutrition were also analyzed, including social factors, health status, and dietary behavior. The average age of these women was 75.9 ± 9.4 years, and 63.8% women lived in urban areas. Of the total respondents, 344 and 716 women were classified as malnutrition and at risk of malnutrition, respectively. Five factors were independently and positively correlated with poor nutrition, including chronic obstructive pulmonary disease (COPD), gastrointestinal disease, depression, cognitive impairment, and comorbidity (≥ 2). Three factors were independently and negatively correlated with poor nutrition, including economic status, meat intake, and fish intake. The older Han women with these five health problems should be given more attention with regards to their nutritional status. Improving economic status, eating more meat and fish were recommended for preventing poor nutrition in older women.

  17. Formation of THMs and HANs during bromination of Microcystis aeruginosa

    Institute of Scientific and Technical Information of China (English)

    Yunzhu Pu; Lingzhao Kong; Xin Huang; Guoji Ding; Naiyun Gao

    2013-01-01

    Bromine-contained disinfectants and biocides are widely used in swimming pools,recreational waters and cooling towers.The objective of this study was to evaluate the formation of thrihalomethanes (THMs) and haloacetonitriles (HANs) and their cytotoxicity in algae solutions during free bromine disinfection.Disinfection by-products formation potential experiments were conducted using modelsolutions containing 7mg/L (as total organic carbon) Microcystis aeruginosa cells.Effects of free bromine dosage,pH and ammonia were investigated.The results showed that brominated disinfection by-products were the major products when free bromine was applied.The total THMs formed during bromination was much as that formed during chlorination,whereas HANs were elevated by using bromination instead of chlorination.Dibromoacetonitrice (C2H2NBr2) and bromoform (CHBr3) were the only detected species during free bromine disinfection.The production of C2H2NBr2 and CHBr3 increased with disinfectant dosage but decreased with dosing ammonia.CHBr3 increased with the pH changing from 5 to 9.However,C2H2NBr2 achieved the highest production at neutral pH,which was due to a joint effect of variation in hydrolysis rate and free bromine reactivity.The hydrolysis of C2H2NBr2 was basecatalytic and nearly unaffected by disinfectant.Finally,estimation of cytotoxicity of the disinfected algae solutions showed that HANs formation was responsible for the majority of toxicity.Considering its highest toxicity among the measured disinfection by-products,the elevated C2H2NBr2 should be considered when using bromine-related algaecide.

  18. Ischemic stroke susceptibility gene in a Northern Han Chinese population

    Institute of Scientific and Technical Information of China (English)

    Haiping Wang; Shujuan Shi; Wenjing Yan; Yan Song; Jingjing Zhan; Chen Zhang; Haiji Wang

    2013-01-01

    Interleukin-18 gene promoter polymorphisms are potential risk factors for ischemic cerebrovascular disease, and the-607C al ele may increase ischemic stroke risk in the Han Chinese population. In the present study, we recruited 291 patients with ischemic cerebrovascular disease from the Affi-liated Hospital of Qingdao University Medical Col ege, China, and 226 healthy controls. Both pa-tients and controls were from the Han population in northern China. Immunoresonance scattering assays detected increased serum amyloid A protein, C-reactive protein, and interleukin-18 levels in ischemic cerebrovascular disease patients compared with healthy controls. Analysis of the-607C/A (rs1946518) polymorphism in the interleukin-18 gene promoter showed ischemic cerebrovascular disease patients exhibited increased frequencies of the CC genotype and C al eles than healthy controls. Genotype and al ele frequencies of the interleukin-18-137G/C (rs187238) polymorphism and the-13T/C (rs11024595) polymorphism in the 5'-flanking region of serum amyloid A, showed no significant difference between the two groups. Multivariate logistic regression analysis on the interleukin-18 promoter A/C genetic locus, for correction of age, gender, history of smoking, hyper-tension, diabetes mel itus, hypercholesteremia, and an ischemic stroke family history, showed ischemic cerebrovascular disease risk in individuals without the A al ele (C homozygotes) was 2.2-fold greater than in A al ele carriers. Overal , our findings suggest that the-13T/C (rs11024595) polymorphism in the 5′-flanking region of serum amyloid A has no correlation with ischemic cere-brovascular disease, but the C al ele of the-607C/A (rs1946518) polymorphism in the interleukin-18 promoter is a high-risk factor for ischemic cerebrovascular disease in the Han population of northern China. In addition, the A al ele is likely a protective gene for ischemic cerebrovascular disease.

  19. Nationalized Judaism and Diasporic Existence. Jakob Klatzkin and Hans Jonas

    Directory of Open Access Journals (Sweden)

    Yotam Hotam

    2008-08-01

    Full Text Available This article characterizes the modern Jewish debate around Zionism as a profound political theological controversy by juxtaposing the works of two significant twentieth-century Jewish scholars, Jakob Klatzkin (1882–1948 and Hans Jonas (1903–1993. While Klatzkin campaigned for Zionism as Gnosticism, Jonas critically challenged this link in his writings from the 1950s and 1960s. In presenting a theological reading of modern Jewish secular thought, the article transcends the political controversy between Zionists and Post-Zionists of the recent decades and proposes a new horizon in the study of Jewish modern-secular thought.

  20. HANS SELYE 70 YEARS LATER: STEROIDS, STRESS ULCERS & H. PYLORI.

    Science.gov (United States)

    Szabó, Sándor

    2014-03-30

    Although Hans Selye is mostly known for his discovery & development of the stress concept, he also introduced the first physiologically sound, structure-activity classification of steroids that was also based on the chemical structure of steroids in 1943. He not only introduced the names of glucocorticoids & mineralocorticoids but discovered the anti- & pro-inflammatory properties, respectively, of these steroids in animal models. Furthermore, he not only described the first stress-induced gastric ulcers in rats (1936) & characterized the first human 'stress ulcers' during the air-raids in London during World War 11 (1943). Thus, Selye was a much more productive & creative scientist than it is generally considered.

  1. RHD gene polymorphism among RhD-negative Han Chinese

    Institute of Scientific and Technical Information of China (English)

    徐群; 张建业; 王勤友; 张世训; 司桂玲

    2003-01-01

    Objective To evaluate the status of eight RHD specific exons in 131 Han Chinese blood donors who were classified as RhD-negative by serological methods and explore the genomic structure of RHD gene among the Han Chinese. The Rh blood group system has the highest prevalence of polymorphisms among human blood group systems and is clinically significant in transfusion medicine. The Rh antigens are expressed on polypeptides encoded by two highly homologous genes, RHD and RHCE. Recent molecular studies have shown that the RhD-negative trait could be generated by multiple genetic mechanisms and is ethnic group-dependent.Methods The polymerase chain reaction using-sequence specific primers (PCR-SSP) was used to amplify exons 2, 3, 4, 5, 6, 7, 9 and 10 of RHD gene and exons 1, 2 and 5 of RHCE gene, as well as intron 4 in each of them.Results The 131 cases of RhD-negative phenotypes consisted of 60 ccee, 58 Ccee, 5 ccEe, 5 CcEe and 3 CCee. Among them, 83 with the Rh ccee or ccEe phenotypes (63.4%) lacked the eight RHD exons indicated above, while 26 cases with the Rh Ccee, CCee, CcEe phenotypes (19.9%) had all the RHD exons examined. Twenty-two individuals with the Ccee, CCee, CcEe phenotypes (16.8%) carried at least one RHD exon. The phenotypes of the RhD negative individuals carrying the RHD gene were Rh CC or Cc, but not cc. Conclusions Three classes of RhD-negative polymorphisms among a population of Han Chinese were observed. Antigen association analysis suggested the existence of a novel class of RhD-negative associated haplotype in Han Chinese. This haplotype consisted of a normal RHCE allele and a nonfunctional RHD gene. It may be beneficial to redefine the RhD-negative blood group among Chinese populations upon clarification of the mechanisms of RHD gene expression and RhD antigen immunization.

  2. Hans-Georg Gadamer en die Ou Testament

    Directory of Open Access Journals (Sweden)

    J. H. le Roux

    2002-08-01

    Full Text Available Hans-George Gadamer and the Old Testament Some aspects of Gadamer�s hermeneutics are discussed below: his view on method, the finiteness of being human, the value of prejudices and so forth. With Gadamer�s help we are also able to think anew about our South African Old Testament tradition. He has perspectives and concepts which can help us to reword the basic questions of Old Testament scholarship. Of course, Gadamer is but one possibility, but he was one of the most important thinkers of the twentieth century. Whoever struggles with him also gains insight into the hermeneutical perspectives of the twentieth century.

  3. Dasar-Dasar Ontologis Pemahaman Hermeneutik Hans-Georg Gadamer

    Directory of Open Access Journals (Sweden)

    Agus Darmaji

    2013-04-01

    Full Text Available Hans-Georg Gadamer explicitly agrees with Heidegger that ‘Being’ is always been understood through the language and the dimension of time. So to catch up the Being, we need to know the Being itself, and to understand it. To understand means to perceive within the time and historicity. This paper will make clear the ontological basics of Gadamer’s hermeneutics containing: the relationship between historical aspect and understanding; hermeneutic discourse and sequential distance; prejudice and understanding; effective historical consciousness; understanding as application; and the structure of questions and answers.DOI: 10.15408/ref.v13i4.911

  4. Complete blood count reference intervals for healthy Han Chinese adults.

    Directory of Open Access Journals (Sweden)

    Xinzhong Wu

    Full Text Available Complete blood count (CBC reference intervals are important to diagnose diseases, screen blood donors, and assess overall health. However, current reference intervals established by older instruments and technologies and those from American and European populations are not suitable for Chinese samples due to ethnic, dietary, and lifestyle differences. The aim of this multicenter collaborative study was to establish CBC reference intervals for healthy Han Chinese adults.A total of 4,642 healthy individuals (2,136 males and 2,506 females were recruited from six clinical centers in China (Shenyang, Beijing, Shanghai, Guangzhou, Chengdu, and Xi'an. Blood samples collected in K2EDTA anticoagulant tubes were analyzed. Analysis of variance was performed to determine differences in consensus intervals according to the use of data from the combined sample and selected samples.Median and mean platelet counts from the Chengdu center were significantly lower than those from other centers. Red blood cell count (RBC, hemoglobin (HGB, and hematocrit (HCT values were higher in males than in females at all ages. Other CBC parameters showed no significant instrument-, region-, age-, or sex-dependent difference. Thalassemia carriers were found to affect the lower or upper limit of different RBC profiles.We were able to establish consensus intervals for CBC parameters in healthy Han Chinese adults. RBC, HGB, and HCT intervals were established for each sex. The reference interval for platelets for the Chengdu center should be established independently.

  5. A study on drought trend in Han River Basin

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Hung-Soo [Sun Moon University, Chonan(Korea); Moon, Jang-Won; Kim, Jae-Hyung; Kim, Joong-Hoon [Korea Univ., Seoul(Korea)

    2000-08-31

    The drought analysis is performed by applications of truncation level method and conditional probability concept for hydrologic time series in Han river basin. The distributed trend of conditional probability is determined using kriging method for the time series. This study uses daily flowrate, monthly rainfall, and daily high temperature data sets. The daily flowrate data of 12 years(1986-1997) is used for the analysis. Also, the 14 years' data sets(1986-1999) for monthly rainfall and daily high temperature obtained from the National Weather Service of Korea are used in this study. In the cases of flowrate and rainfall data sets, the estimated value corresponding to the truncation level is decreased as the truncation level is increased but in the high temperature data, the value is increased as the truncation level is increased. The conditional probability varies according to the observations and sites. However, the distributed trend of drought is similar over the basin. As a result, the possibility of the drought is high in the middle and lower parts of Han river basin and thus it is recommended the distributed trend of drought be considered when the plan or measures for drought are established. (author). 10 refs., 9 tabs., 5 figs.

  6. The anatomist Hans Elias: A Jewish German in exile.

    Science.gov (United States)

    Hildebrandt, S

    2012-04-01

    Hans Elias (1907 to 1985) was an anatomist, an educator, a mathematician, a cinematographer, a painter, and a sculptor. Above all, he was a German of Jewish descent, who had to leave his home country because of the policies of the National Socialist (NS) regime. He spent his life in exile, first in Italy and then in the United States. His biography is exemplary for a generation of younger expatriates from National Socialist Germany who had to find a new professional career under difficult circumstances. Elias was a greatly productive morphologist whose artistic talent led to the foundation of the new science of stereology and made him an expert in scientific cinematography. He struggled hard to fulfill his own high expectations of himself in terms of his effectiveness as a scientist, educator, and politically acting man in this world. Throughout his life this strong-willed and outspoken man never lost his great fondness for Germany and many of its people, while reserving some of his sharpest criticism for fellow anatomists who were active in National Socialist Germany, among them his friend Hermann Stieve, Max Clara, and Heinrich von Hayek. Hans Elias' life is well documented in his unpublished diaries and memoirs, and thus allows fresh insights into a time period when some anatomists were among the first victims of NS policies and other anatomists became involved in the execution of such policies.

  7. Hans H. Ussing - scientific work: contemporary significance and perspectives

    DEFF Research Database (Denmark)

    Larsen, Erik Hviid

    2002-01-01

    As a zoologist, Hans H. Ussing began his scientific career by studying the marine plankton fauna in East Greenland. This brought him in contact with August Krogh at the time George de Hevesy, Niels Bohr and Krogh planned the application of artificial radioactive isotopes for studying the dynamic...... such as exchange diffusion, unidirectional fluxes, flux-ratio equation, and solvent drag. Combining methods of biophysics with radioactive isotope technology, Ussing introduced and defined the phrases ‘short-circuit current', ‘active transport pathway' and ‘shunt pathway', and with frog skin as experimental model...... studies of high and low resistance epithelia and generalized the description of epithelial transport. He devoted the last decade of his scientific life to solute-coupled water transport. He introduced the sodium recirculation theory of isotonic transport, and in an experimental study, he obtained...

  8. Responsibility to Nature? Hans Jonas and Environmental Ethics

    Directory of Open Access Journals (Sweden)

    Peter Wolsing

    2013-11-01

    Full Text Available This paper presents the philosopher Hans Jonas’s idea of an environmental ethics. Through an outline of the development of man’s relation to nature from Greek antiquity to the present it is argued that science and technology in modernity favour a relation of exploitation which is partly the cause of fatal climate changes. Through Jonas’s philosophical notion of an ontology of man as an alternative to classical dualism and by means of a turn to an ontological interpretation of Kant’s categorical imperative, it is argued that mankind has a responsibility to both coming generations and to the biosphere as a whole. Not only does this ontological shift from philosophy of mind to an ontology of man transcend dualism in philosophy, it throws a new critical light on the technological development and suggests a new way of considering man’s place in the cosmos.

  9. Hans Hinterreiter’s non-linear transformations

    DEFF Research Database (Denmark)

    Makovicky, Emil

    Hans Hinterreiter (1902-1989) was a Swiss painter, belonging to the Constructivist movement, who spent most of his life in Ibiza, Spain. Since 1930 he occupied himself with the laws of form and colour. Parallel to Escher, he discovered laws of coloured symmetry before crystallographers started...... poster illustrates four different cases of this process, starting always with a plane-group pattern and showing both the application of non-linear transformations and coloured symmetry. In his more complex patterns, two of which are shown on the poster, Hinterreiter created domains of affinely......-step approach that combines plane group patterns with the principles of coloured symmetry and nonlinear transformations, his understanding of crystallographic and non-crystallographic symmetry and a meticulous application of these principles even to the most complex patterns produced a legacy close to the heart...

  10. [Hans Selye, the grandmaster of creativity and originality].

    Science.gov (United States)

    Somogyi, Árpád

    2015-08-30

    Hans Selye, the father of the stress concept, was a giant of science of the twentieth century. Beyond his best-known work on stress, he also made several discoveries on various other fields of experimental medicine. He described and characterized various pluricausal diseases. In addition, he made pivotal contributions to the broad field of endocrinology, especially to the classification of steroids and to our better understanding of their mode of action. He developed surgical technics and experimental animal models suitable for studying the pathogenesis and prevention of human diseases. Selye was an extremely well educated, highly intelligent and disciplined individual, an original and creative scientist, an outstanding teacher, a philosopher, a prolific author, a fabulous communicator and a gifted organizer successfully establishing, developing and managing a major academic research institution, the word-famous Institute of Experimental Medicine and Surgery of the University of Montreal.

  11. From chemistry to consciousness the legacy of Hans Primas

    CERN Document Server

    Müller-Herold, Ulrich

    2016-01-01

    This book reflects on the significant and highly original scientific contributions of Hans Primas. A professor of chemistry at ETH Zurich from 1962 to 1995, Primas continued his research activities until his death in 2014. Over these 50 years and more, he worked on the foundations of nuclear magnetic resonance spectroscopy, contributed to a number of significant issues in theoretical chemistry, helped to clarify central topics in quantum theory and the philosophy of physics, suggested innovative ways of addressing interlevel relations in the philosophy of science, and introduced cutting-edge approaches in the flourishing young field of scientific studies of consciousness. His work in these areas of research and its continuing impact is described by noted experts, colleagues, and collaborators of Primas. All authors contextualize their contributions to facilitate the mutual dialog between these fields.

  12. [The psychobiology of Hans Lungwitz (1881-1967)].

    Science.gov (United States)

    Becker, Reinhold

    2003-01-01

    Hans Lungwitz began to formulate his concept of philosophical and medical anthropology in 1924, and continued to develop it until his death in 1967. From his long experience as a neurologist, he arrived at a comprehensive theory of psychobiology which describes mental processes as biological / physiological function of neural structures in the human brain. Lungwitz's approach to holistic biological view of thought and experience to brain function and reflex behaviour, and provides a holistic biological view of the human brain, free from metaphysics. This is shown here as: the subject-object-relationship, the human being described as a reflex system; the psychobiology of language and speech; the way a person perceives (Weltanschauung); illness as infantilism in general and recover therefrom, especially in the context of treatment by the method of cognitive therapy, inaugurated by Lungwitz.

  13. The legacy of Hans Molisch (1856-1937), photosynthesis savant.

    Science.gov (United States)

    Gest, H

    1991-10-01

    Hans Molisch (1856-1937) was an exceptionally gifted and productive researcher who had broad interests in plant biology, physiology and biochemistry. In addition, he pioneered in isolating a number of species of purple photosynthetic bacteria in pure culture (including Rhodobacter capsulatus), which facilitated his discovery of basic aspects of bacterial photosynthesis. Molisch demonstrated conclusively that molecular oxygen is not produced by photosynthetic bacteria, and discovered the photoheterotrophic growth mode. The range of Molisch's research accomplishments was impressive, and he emerges as a major figure in the history of photosynthesis research. This essay reviews the numerous research contributions made by Molisch, particularly in regard to advancing knowledge of the several forms of photosynthetic metabolism. An English translation of his 1914 paper on the photosynthetic creation of visual images on leaves is included as an Appendix.

  14. Introduction to Professor HAN Jing-xian's Academic Thoughts

    Institute of Scientific and Technical Information of China (English)

    陆明霞; 丁晓蓉

    2006-01-01

    @@ Professor HAN Jing-xian graduated from the Department of Medicine in Tianjin Medical University in 1970. He made a further study of experimental medicine in Kitasato University, Japan between 1987 and 1988. He was engaged in aging research in mouse in Kyoto University, Japan between 1988-1989, and in practicing traditional Chinese medicine(TCM) in Mutian and other Hospitals from 1991 to 1994. In 1997, he won an excellent returned students award from Ministry of Health and was awarded special allowance by State Council. As a research fellow, he won an award of national scientific and technical progress and seven awards of local scientific and technical progress. He published more than twenty articles at home and abroad, including five SCI papers; and wrote four monographs, one of which, Acupuncture Techniques (in Japanese) has been considered as a guidance book for acupuncture practice in the acupuncture circle in Japan.

  15. CRITICAL PERSPECTIVES ON HANS MORGENTHAU'S APPROACH TO INTERNATIONAL RELATIONS

    OpenAIRE

    Chambers, Gary

    2015-01-01

       Hans Morgenthau'nun Uluslararası İlişkiler bilimine katkısı 1970'lere kadar alanda üstünlüğünü sürdürmüştür. Bu makalenin amacı, Morgenthau'nun realizm üzerine görüşlerinin uluslararası ilişkiler (IR) alanında daha sonraki çalışmalarda nasıl bir etki bıraktığını ve Morgenthau ve eleştirenleri arasında süregelen tartışmanın önemli yönlerini ortaya koymaktır. Morgenthau'nun realizminin açıklayıcı gücüne ve cimriliğinin ve açıklığının yararlarına bakmaksızın, Morgenthau'nun düşünüşüne, diğer ...

  16. Hans Loewald, psychoanalysis, and the project of autonomy.

    Science.gov (United States)

    Whitebook, Joel

    2008-12-01

    For some time psychoanalysts have tended to view Freud's cultural writings--concerning modernity, secularism, science, and religion--disparagingly, seeing them as the unscientific speculations of a misguided genius. But the questions Freud explored in those works are pressing topics that deserve serious attention. Just as fascism provided the historical context in which the critical theorists of the Frankfurt School developed a psychoanalytic social theory in the 1930s and 1940s, so the rise of fundamentalism demands a similar effort today. The "project of autonomy" conceptualized by the psychoanalyst-philosopher Castoriadis can be used to situate psychoanalysis in its broader historical context, as part of the emancipatory movement of modernity, and to elucidate fundamentalism as an attempt to turn back that project and reinstate the values of premodern traditional societies. Because the widespread aversion to secularism today is in no small degree the responsibility of secularists themselves--Freud's relatively crude and simplistic disregard of some of the deepest yearnings of humankind is a case in point--it is time to formulate, using the work of Hans Loewald, a more sensitive and sophisticated psychoanalytic view of religion. Yet psychoanalytic secularists must avoid overcompensating for past mistakes by giving too much ground to antisecularists. The legitimate desire to do justice to religion must not trump the need to advance the project of autonomy as a first priority.

  17. La agonía del Eros, Han (2014.

    Directory of Open Access Journals (Sweden)

    Laura Díaz Traversa

    2016-11-01

    Full Text Available Byung-Chul Han, Dr. en Filosofía de origen coreano, realizó sus estudios en Alemania, donde reside actualmente y se desempeña como docente de Filosofía y Estudios Culturales en la Universidad de las Artes de Berlín. Desde el punto de vista teórico-académico se inscribe en el Pensamiento Crítico de la escuela de Frankfurt, siendo alumno privilegiado de Honneth. Es considerado una de las voces filosóficas más prestigiosas de dicho país, y sus obras se caracterizan por ser breves, de fácil lectura, sorprendiendo al público por su fuerza y pertinencia en la actualidad. La agonía del Eros es la tercera obra del autor traducida al castellano y promete seguir el mismo camino que las anteriores, es decir, convertirse en una obra fundamental del Pensamiento Crítico.

  18. Risks associated with premature ovarian failure in Han Chinese women.

    Science.gov (United States)

    Wang, Huidan; Chen, Haitao; Qin, Yingying; Shi, Zhuqing; Zhao, Xiaoming; Xu, Jianfeng; Ma, Bowen; Chen, Zi-Jiang

    2015-04-01

    In this retrospective study, the relationship between demographic characteristics, past medical history, general lifestyle habits and susceptibility of premature ovarian failure (POF) in Han Chinese population was investigated. Five hundred and fifty-three patients with POF and 400 women with normal ovarian function were recruited. A questionnaire was designed to gather information from responders. Logistic regression was carried out to calculate odds ratios (OR), 95% confidence intervals (95% CI) and P-values. History of pelvic surgery, mumps, having relatives with menstrual abnormalities and exposure to chemical agents were significantly associated with increased risk of POF (OR 5.53 [2.15 to 14.23]; 3.26 [2.38 to 4.47]; 28.12 [8.84 to 89.46]; 4.47 [2.09 to 9.58]). Vegetarian diet, tea and mineral water consumption reduced the risk of POF (OR 0.27 [0.19 to 0.37]; 0.04 [0.03 to 0.07]; 0.63 [0.47 to 0.85], respectively). Heredity, pelvic surgery, mumps and exposure to chemical agents were identified as risk factors for POF, whereas vegetarian diet, tea consumption and mineral water drinking were protective. Therefore, genetic consultation could help those women whose relatives manifested an early or premature menopause to avoid the consequences of possible premature ovarian function cessation. Avoidance of exposure to endocrine disrupters and flavonoids intake should be considered.

  19. CRITICAL PERSPECTIVES ON HANS MORGENTHAU'S APPROACH TO INTERNATIONAL RELATIONS

    OpenAIRE

    Chambers, Gary

    2017-01-01

       Hans Morgenthau'nun Uluslararası İlişkiler bilimine katkısı 1970'lere kadar alanda üstünlüğünü sürdürmüştür. Bu makalenin amacı, Morgenthau'nun realizm üzerine görüşlerinin uluslararası ilişkiler (IR) alanında daha sonraki çalışmalarda nasıl bir etki bıraktığını ve Morgenthau ve eleştirenleri arasında süregelen tartışmanın önemli yönlerini ortaya koymaktır. Morgenthau'nun realizminin açıklayıcı gücüne ve cimriliğinin ve açıklığının yararlarına bakmaksızın, Morgenthau�...

  20. Nuclear forces the making of the physicist Hans Bethe

    CERN Document Server

    Schweber, Silvan S

    2012-01-01

    On the fiftieth anniversary of Hiroshima, Nobel-winning physicist Hans Bethe called on his fellow scientists to stop working on weapons of mass destruction. What drove Bethe, the head of Theoretical Physics at Los Alamos during the Manhattan Project, to renounce the weaponry he had once worked so tirelessly to create? That is one of the questions answered by "Nuclear Forces", a riveting biography of Bethe's early life and development as both a scientist and a man of principle. As Silvan Schweber follows Bethe from his childhood in Germany, to laboratories in Italy and England, and on to Cornell University, he shows how these differing environments were reflected in the kind of physics Bethe produced. Many of the young quantum physicists in the 1930s, including Bethe, had Jewish roots, and Schweber considers how Liberal Judaism in Germany helps explain their remarkable contributions. A portrait emerges of a man whose strategy for staying on top of a deeply hierarchical field was to tackle only those problems h...

  1. Hans Küpper discusses science and venture capital.

    Science.gov (United States)

    Küpper, Hans

    2004-11-01

    Hans Küpper has over 30 years of experience in the biotechnology industry in areas from research to R&D management, technology assessment and business acquisitions. He received his PhD in 1974 from the University of Heidelberg. After additional academic research at the Massachusetts Institute of Technology in the USA and at the University of Heidelberg, Germany, he joined Biogen in 1980. Here, he held various R&D positions, the last of which was Assistant Research Director. In 1985, he joined Behringwerke AG, Marburg, to build up and head the company's Molecular Biology Department and thereafter became Head of R&D of the Immunology/Oncology Business Unit. In 1999 he joined Global Life Science Ventures at their Munich office. Dr Küpper is the author of numerous publications and patents/applications and has also served as a consultant to the Pharmaceutical Industry and the European Commission. He is a board member of several early stage companies in the life sciences.

  2. Hans Christian Ørsted, narratives, oeuvres and physics education

    Science.gov (United States)

    Michelsen, Claus

    2017-05-01

    In 1820 the Danish scientist Hans Christian Ørsted discovered the relationship between electricity and magnetism by his famous wire-compass experiment. Ørsted was one of the foremost scientists of the nineteenth century, and he was also one of the leading figures in Denmark in the 19th century with a vital influence in the fields of aesthetics, philosophy, education, politics and religion. In this paper the work and life of Ørsted is placed in a school context with the rationale to accentuate that learning of physics needs to be accompanied by learning about physics, its history, its interrelations with culture, worldviews, and commerce, its philosophical assumptions, its epistemology and methodology. Narratives are introduced as a pedagogical support to this approach and two concrete examples of teaching sequences centred on the work and life of Ørsted is described in grade 7 and grade 9 classes, respectively. A prominent feature of the sequences was that all the activities of the pupils as an outcome should have a product. Products like a movie, a loudspeaker, a fairy tale or a newspaper played an important role by encouraging the pupils to produce both personally meaningful works as well as products that are useful for their community.

  3. [Hans von Hattingberg between psychoanalysis and National Socialism].

    Science.gov (United States)

    Keifenheim, Katharina Eva

    2011-01-01

    Hans von Hattingberg (1879-1944) worked as a neurologist and psychoanalyst in Munich and Berlin from about 1910 to 1944. He was a prolific writer, but met with increasing disapproval from Freud and his circle. An advocate of the union of different psychotherapeutic schools, he was initially a marginal figure in the professional field. With Hitler's rise to power his career prospered: He was offered the position of a lecturer for psychotherapy and became head of the research department at the "Göring Institute". He came to prominence with his writings on the "Neue deutsche Seelenheilkunde" despite the fact that this was never his preferred topic. The main themes of his publications were marriage, love and female emancipation. Those works contain only little of the standard Nazi ideology of the time. Not only was Hattingberg never a member of the NSDAP (the ruling party), but in some respects he could conceivably be considered a member of the resistance. The article outlines the most important stages of Hattingberg's life and focuses on the question of how he positioned himself after 1933, when it became vital for him to reconcile psychoanalysis and National Socialism.

  4. Type 2 Diabetes in Han Chinese in Hubei

    Science.gov (United States)

    Abdo Saif Dehwah, Mustafa; Shuang, Zhang; Yan, Wang; Chan, Peng; Huang, Qing-Yang

    The aim of this study was to investigate the association between Pro12Ala polymorphism in the PPARγ2 gene and type 2 diabetes mellitus in Han Chinese in Hubei. Peroxisome proliferator activated receptorγ2 (PPARγ2) is a nuclear receptor plays a key role in regulation of adipocyte differentiation, lipid metabolism, insulin sensitivity and the development of type 2 diabetes mellitus (T2DM). There are various studies have provided evidence for the association between common Pro12Ala polymorphism in the PPARγ2 gene and type 2 diabetes mellitus, but the results are controversial and depend on ethnicity. So we conducted a case-control association study among 330 T2DM patients and 212 controls with family-based and random case-control designs. The genotypes of the PPARγ2 Pro12Ala polymorphism were detected by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFL) method. The result indicated that the Pro12 allele was associated with type 2 diabetes in this study population.

  5. Bible Depicted in 2,000-year-old Han Dynasty Stone Carvings

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Wang Weifan is a member of the standing committee of the China Christian Council, and a Christian theology education professor. He recently discovered that several Eastern Han Dynasty museum exhibits in the Jiangsu Xuzhou Han Dynasty Stone Carving Museum include depictions of the bible and of early

  6. Som i et spejl - Hans Egede-receptionen gennem tre hundrede år

    DEFF Research Database (Denmark)

    Kjærgaard, Kathrine

    2008-01-01

    fyldigt omtalt i Ove Mallings meget læste: Store og gode Handlinger af Danske, Norske og Holstenere fra 1777, og der kom flere kobberstik med hans portræt. Hans Egede plejer de kobbesyge - en scene fra koppeepidemien i Godthåb 1733 af den bekendte kobberstikker Johann Friedrich Clemens efter tegning af...

  7. Jean Calvin (1509-1564) - i 500-året for hans fødsel

    DEFF Research Database (Denmark)

    Jørgensen, Ninna

    2010-01-01

    Artiklen er en introduktion til Calvins liv og tankeverden i anledning af 500-året for hans fødsel. Udgangspunkt er hans selvforståelse, som den kommer til udtryk i hans Salmekommentar og den forståelse af Salmerne som en sjælens "anatomi" og en vejledning til bøn, som står ved roden af hans...... teologi. Calvins humanistiske baggrund, engagement i reformationen, eksil, og ydre og indre modstandere beskrives sammen med et overblik over hans teologi, som den fremstår i Institutio. Denne inkluderer den dobbelte erkendelse af Gud som Skaber og som Frelser, hvori forsynet er en væsentlig del af første...

  8. 'Little Hans': from his phobic episode to becoming an opera director.

    Science.gov (United States)

    Vives, Jean-Michel

    2012-08-01

    'Little Hans' is one of the most highly commented cases in the psychoanalytic literature. His work as an opera director from 1925 in Europe and then in the United States of America is much less well known. This may seem especially surprising given that Freud very soon detects Hans's emerging interest in this subject. Yet Freud does not mention it either in 1909 when he reports the case, or when Hans visits him in 1922, even though Hans had already decided to become an opera director at this point. The author of this article endeavours to show how this artistic choice could be understood as a way of accommodating, in a double transference relationship with Freud and with his father, the unanalysed residue of the 'Krawall' (a term invented by Hans) and 'the black thing', both of which appeared during the phobic period.

  9. The regulation of HanA during heterocyst development in cyanobacterium Anabaena sp. PCC 7120.

    Science.gov (United States)

    Lu, Jing-Jing; Shi, Lei; Chen, Wen-Li; Wang, Li

    2014-10-01

    In response to deprivation of combined nitrogen, the filamentous cyanobacterium Anabaena sp. strain PCC 7120 develops heterocyst, which is specifically involved in the nitrogen fixation. In this study, we focused on the regulation of HanA, a histone-like protein, in heterocyst development. Electrophoretic mobility shift assay results showed that NtcA, a global nitrogen regulator necessary for heterocyst differentiation, could bind to two NtcA-binding motifs in the hanA promoter region. qPCR results also showed that NtcA may regulate the expression of hanA. By using the hanA promoter-controlled gfp as a reporter gene and performing western blot we found that the amount of HanA in mature heterocysts was decreased gradually.

  10. 释“寒池”、“寒庭”与“寒夜”%An Explanation of "Han Chi", "Han Ting" and "Han Ye"

    Institute of Scientific and Technical Information of China (English)

    叶贵良

    2011-01-01

    在道经中,“寒池”、“寒庭”都有地狱刑罚之池、人身命门、月中广寒之池、北极元福弃贤世界郁单之国的神池等意思;“寒夜”则有地狱的意思,此外,该词还可作地狱曹府之名。%In Taoist scripture, "han chi" and "han ting" take the meanings like a pool with hell, penalty, fate, cold-evil, etc. Except the meaning of hell, "han ye" is the synonym of hell.

  11. Modern use of Chinese herbal formulae from Shang-Han Lun

    Institute of Scientific and Technical Information of China (English)

    CHEN Fang-pey; CHEN Fun-jou; JONG Maw-shiou; TSAI Hui-lin; WANG Jen-ren; HWANG Shinn-jang

    2009-01-01

    Background The Chinese medical archive,Shang-Han Lun,is said to be written by ZHANG Zhong-jing (150-219 A.D.).This great influential work introduced the specific symptoms of six-channel disorders (Tai-Yang,Yang-Ming,Shao-Yang,Tai-Yin,Shao-Yin,and Jue-Yin) and their corresponding treatments,the combined syndromes,deterioration due to malpractice,and the concept of six-channel transitions.The concept of Shang-Han Lun is widely accepted by Chinese herbal doctors.However,no clinical data about Shang-Han symptoms are described in oriental or western medical reports.Methods The clinical prescription data of traditional Chinese medicine visits were extracted under the National Health Insurance in Taiwan.The application rate of 42 Shang-Han formulae in clinical practice was analyzed in detail with the software SPSS.Results Between 1999 and 2002,the prescription rate of Shang-Han formula was only 5.22% among a total of 528 889 576 Chinese herbal formula prescriptions.The most frequently used formula was Tai-Yang formulae (71.31%),followed by Shao-Yang formulae (17.49%) and the most commonly prescribed individual Shang-Han formulae were Ge-Gen Tang (16.11%),Shao-Yao-Gan-Cao Tang (12.97%),Xiao-Qing-Long Tang (11.79%),Ban-Xia Xie-Xin Tang (10.24%),and Xiao-Chai-Hu Tang (9.11%),which comprised 60.22% of the utilization rate of total Shang-Han formulae.Conclusions From the prescription patterns of Shang-Han formulae,there was no evidence of transitions among the six channels.Despite the fundamental role of Shang-Han Lun in traditional Chinese medicine,prescription of Shang-Han formulae was limited in clinical practice.

  12. Its not refrigerator art / Laurence Boyce

    Index Scriptorium Estoniae

    Boyce, Laurence

    2011-01-01

    27. aprillil avati Tallinna lauluväljakul koolinoorte nüüdiskunsti triennaal "Eksperimenta!". Lauluväljaku näitusesaalides, õuealal ja Maarjamäe lossis on väljas 13 riigi (loetletud) koolinoorte tööd

  13. Its not refrigerator art / Laurence Boyce

    Index Scriptorium Estoniae

    Boyce, Laurence

    2011-01-01

    27. aprillil avati Tallinna lauluväljakul koolinoorte nüüdiskunsti triennaal "Eksperimenta!". Lauluväljaku näitusesaalides, õuealal ja Maarjamäe lossis on väljas 13 riigi (loetletud) koolinoorte tööd

  14. Taevalik trio / Laurence Lumiére

    Index Scriptorium Estoniae

    Lumiére, Laurence

    2000-01-01

    Actionfilm "Charlie inglid" : režissöör Joseph McGinty Nichol : peategelased : Drew Barrymore (. Ka produtsent), Cameron Diaz ja Lucy Liu : Ameerika Ühendriigid 2000. Ka : Nädal nr. 47, lk. 90-91

  15. Saag käima! / Laurence Lumiere

    Index Scriptorium Estoniae

    Lumiere, Laurence

    2006-01-01

    Tallinnas on ekraanil õudusfilm "Texase mootorsaemõrvad : algus" ("The Texas Chainsaw Massacre : The Beginning") : režissöör Jonathan Liebesman : Ameerika Ühendriigid 2006. Ülevaade sama teema ja pealkirjaga rohketest eelkäijatest kuni esimeseni - 1974.a. valminud Tobe Hooperi filmini "Texase mootorsaemõrvad"

  16. Verine kättemaksumuusikal / Laurence Lumiere

    Index Scriptorium Estoniae

    Lumiere, Laurence

    2008-01-01

    Õudusmuusikal "Sweeney Todd : Fleet Streeti deemonlik habemeajaja" Stephen Sondheimi muusikali alusel : režissöör Tim Burton : peaosades Johnny Depp, Helena Bonham Carter : Ameerika Ühendriigid - Suurbritannia 2007

  17. Rõõmus roheline / Laurence Lumiere

    Index Scriptorium Estoniae

    Lumiere, Laurence

    2007-01-01

    Täispikk animafilm "Shrek Kolmas" ("Shrek the Third") : režissöör Chris Miller : eestikeelse dublaazhi režissöör Janno Põldma : Ameerika Ühendriigid 2007. Ära on nimetatud ka kõikide rollide eesti keelde dubleerijad

  18. 2x Ben Affleck / Laurence Lumiere

    Index Scriptorium Estoniae

    Lumiere, Laurence

    2007-01-01

    Põnevusfilm "Hollywoodland" : režissöör Allen Coulter : Ameerika Ühendriigid 2006 ja põnevuskomöödia "Äss mättasse" ("Smokin' Aces") : režissöör Joe Carnahan : Suurbritannia - Prantsusmaa - Ameerika Ühendriigid 2007. Mõlemas mängib Ben Affleck

  19. Kaunitar, koletis ja... anarhia! / Laurence Lumiere

    Index Scriptorium Estoniae

    Lumiere, Laurence

    2006-01-01

    USA - Saksamaa ulmepõnevik "V nagu veritasu" ("V for Vendetta") : režissöör James McTeigue : osades Natalie Portman, Hugo Weaving : 2005. Aluseks on Alan Moore'i samanimeline koomiks, mille vennad Larry ja Andy Wachowski stsenaariumiks töötlesid

  20. 2x Ben Affleck / Laurence Lumiere

    Index Scriptorium Estoniae

    Lumiere, Laurence

    2007-01-01

    Põnevusfilm "Hollywoodland" : režissöör Allen Coulter : Ameerika Ühendriigid 2006 ja põnevuskomöödia "Äss mättasse" ("Smokin' Aces") : režissöör Joe Carnahan : Suurbritannia - Prantsusmaa - Ameerika Ühendriigid 2007. Mõlemas mängib Ben Affleck

  1. Kõrged kontsad, kokteilid ja Cosmo / Laurence Lumiere

    Index Scriptorium Estoniae

    Lumiere, Laurence

    2008-01-01

    Menutelesarja "Seks ja linn" peategelastega samanimelisest mängufilmist (režissöör Michael Patrick King). Seriaali sünniloost, alates ideest produtsent Darren Stari peas ning filmi ja seriaali võrdlusest

  2. Black power! / Laurence Lumiére

    Index Scriptorium Estoniae

    Lumiére, Laurence

    2000-01-01

    Mängufilm "Shaft" : režissöör John Singelton : nimiosas Samuel L. Jackson : Ameerika Ühendriigid 2000. Sama pealkirjaga film, praeguse eelkäija ja eeskuju, jõulisest mustast politseinikust linastus 1971. aastal ning on üks olulisemaid filme eneseteadvuse kasvatamisel USAs. Ka : Teleleht nr. 42, lk. 36-37

  3. Taevalik trio / Laurence Lumiére

    Index Scriptorium Estoniae

    Lumiére, Laurence

    2000-01-01

    Actionfilm "Charlie inglid" : režissöör Joseph McGinty Nichol : peategelased : Drew Barrymore (. Ka produtsent), Cameron Diaz ja Lucy Liu : Ameerika Ühendriigid 2000. Ka : Nädal nr. 47, lk. 90-91

  4. Saag käima! / Laurence Lumiere

    Index Scriptorium Estoniae

    Lumiere, Laurence

    2006-01-01

    Tallinnas on ekraanil õudusfilm "Texase mootorsaemõrvad : algus" ("The Texas Chainsaw Massacre : The Beginning") : režissöör Jonathan Liebesman : Ameerika Ühendriigid 2006. Ülevaade sama teema ja pealkirjaga rohketest eelkäijatest kuni esimeseni - 1974.a. valminud Tobe Hooperi filmini "Texase mootorsaemõrvad"

  5. Kõrged kontsad, kokteilid ja Cosmo / Laurence Lumiere

    Index Scriptorium Estoniae

    Lumiere, Laurence

    2008-01-01

    Menutelesarja "Seks ja linn" peategelastega samanimelisest mängufilmist (režissöör Michael Patrick King). Seriaali sünniloost, alates ideest produtsent Darren Stari peas ning filmi ja seriaali võrdlusest

  6. Armastusest nii ja teisiti / Laurence Lumiere

    Index Scriptorium Estoniae

    Lumiere, Laurence

    2007-01-01

    Romantiline komöödiafilm "Viimane suudlus" ("The Last Kiss") : režissöör Tony Goldwyn : Ameerika Ühendriigid, 2006 ja põnevusfilm "Ghost Rider - põrguline" : režissöör Mark Steven : peaosas Nicolas Cage : Ameerika Ühendriigid, 2007

  7. Ämblikmehe uus tulemine / Laurence Lumiere

    Index Scriptorium Estoniae

    Lumiere, Laurence

    2004-01-01

    Mängufilm "Ämblikmees 2" ("Spider Man 2") : režissöör Sam Raimi : peaosatäitja Tobey Maguire : Ameerika Ühendriigid 2004. Filmi aluseks olev Stan Lee ja Steve Ditko koomiks alustas ilmumist 1962. aastal

  8. Ämblikmehe uus tulemine / Laurence Lumiere

    Index Scriptorium Estoniae

    Lumiere, Laurence

    2004-01-01

    Mängufilm "Ämblikmees 2" ("Spider Man 2") : režissöör Sam Raimi : peaosatäitja Tobey Maguire : Ameerika Ühendriigid 2004. Filmi aluseks olev Stan Lee ja Steve Ditko koomiks alustas ilmumist 1962. aastal

  9. Kaunitar, koletis ja... anarhia! / Laurence Lumiere

    Index Scriptorium Estoniae

    Lumiere, Laurence

    2006-01-01

    USA - Saksamaa ulmepõnevik "V nagu veritasu" ("V for Vendetta") : režissöör James McTeigue : osades Natalie Portman, Hugo Weaving : 2005. Aluseks on Alan Moore'i samanimeline koomiks, mille vennad Larry ja Andy Wachowski stsenaariumiks töötlesid

  10. 15. XI kell 17 avatakse EKA galeriis...

    Index Scriptorium Estoniae

    2004-01-01

    Näitus "ERKI moe-show" 10 aastat", mille koostasid Karolin Kuusik, Gerli Liivamägi, Kristina Paju, Külli-Kerttu Siplane ja Agne Talu. Eksponeeritakse ka Jaanus Orgusaare, Vassilissa, Aldo Järvsoo ning Hula noortekollektsiooni esinemiste meeldejäävamaid hetki. 20. XI kinos Kosmos ERKI moeetendus "Go". Lavastuse autorid Taavet Jansen ja Oksana Titova, kunstiline juht Ain Nurmela, videokunstnik Taavi Warm, graafiline kujundus Martin Eelmalt, helikujundus Remi Prualilt

  11. 15. XI kell 17 avatakse EKA galeriis...

    Index Scriptorium Estoniae

    2004-01-01

    Näitus "ERKI moe-show" 10 aastat", mille koostasid Karolin Kuusik, Gerli Liivamägi, Kristina Paju, Külli-Kerttu Siplane ja Agne Talu. Eksponeeritakse ka Jaanus Orgusaare, Vassilissa, Aldo Järvsoo ning Hula noortekollektsiooni esinemiste meeldejäävamaid hetki. 20. XI kinos Kosmos ERKI moeetendus "Go". Lavastuse autorid Taavet Jansen ja Oksana Titova, kunstiline juht Ain Nurmela, videokunstnik Taavi Warm, graafiline kujundus Martin Eelmalt, helikujundus Remi Prualilt

  12. 1. V kell 19 algab Tartu Sadamateatris...

    Index Scriptorium Estoniae

    2005-01-01

    Tartu Kõrgema Kunstikooli tekstiiliosakonna korraldatud üritus "Projekt: Mood-Performance-Tants". Esineb Viljandi Kultuuriakadeemia tantsutrupp Jaanika Müürsepa juhendamisel. Baby Universali moeetendusel esinevad Maru, Kätlin Kängsepp, Liisi Eesmaa, Jaanika Terasmaa, Ieva Veita, Ilze Adumane jt. Muusikat teevad Kiwa, King-Bit, Fabrique jt.

  13. Kelle huve kaitseb riigieelarvekava? / Eiki Nestor

    Index Scriptorium Estoniae

    Nestor, Eiki, 1953-

    2004-01-01

    Ilmunud ka: Lääne Elu, 28. sept. 2004, lk. 2; Hiiu Leht, 28. sept. 2004, lk. 2; Pärnu Postimees, 28. sept. 2004, lk. 15; Võrumaa Teataja, 28. sept. 2004, lk. 2; Sakala, 29. sept. 2004, lk. 2; Meie Maa, 29. sept. 2004, lk. 2; Nädaline, 30. sept. 2004, lk. 4; Põhjarannik, 30. sept. 2004, lk. 2; Severnoje Poberezhje, 30. sept. 2004, lk. 2; Elva Postipoiss, 2. okt. 2004, lk. 4; Videvik, 7. okt. 2004, lk. 2; Sotsiaaldemokraat, okt., nr. 97, 2004, lk. 3. Autor kritiseerib valitsuse esitatud 2005. aasta riigieelarve eelnõu

  14. Kelle huve kaitseb riigieelarvekava? / Eiki Nestor

    Index Scriptorium Estoniae

    Nestor, Eiki, 1953-

    2004-01-01

    Ilmunud ka: Lääne Elu, 28. sept. 2004, lk. 2; Hiiu Leht, 28. sept. 2004, lk. 2; Pärnu Postimees, 28. sept. 2004, lk. 15; Võrumaa Teataja, 28. sept. 2004, lk. 2; Sakala, 29. sept. 2004, lk. 2; Meie Maa, 29. sept. 2004, lk. 2; Nädaline, 30. sept. 2004, lk. 4; Põhjarannik, 30. sept. 2004, lk. 2; Severnoje Poberezhje, 30. sept. 2004, lk. 2; Elva Postipoiss, 2. okt. 2004, lk. 4; Videvik, 7. okt. 2004, lk. 2; Sotsiaaldemokraat, okt., nr. 97, 2004, lk. 3. Autor kritiseerib valitsuse esitatud 2005. aasta riigieelarve eelnõu

  15. Täna kell 17 avatakse tarbekunstimuuseumis...

    Index Scriptorium Estoniae

    2003-01-01

    28. XI Leo Rohlini keraamikanäituse avamine ja kunstniku "Keraamika käsiraamatu" esitlus. Näituse kuraator Airi Ligi, kujundaja Mari Kurismaa, kataloogi kujundaja Denes Farkas. L. Rohlini loengud: "Eesti keraamika ja keraamikakoolitus" 12. I 2004, "Glasuur - kas imelihtne või lihtsalt ime? Ekspositsiooni analüüs" 13. I 2004

  16. 27. V kell 16 avatakse Niguliste kirikus...

    Index Scriptorium Estoniae

    2002-01-01

    EKA interdistsiplinaarsete kunstide eriala magistritööde näitus "Nagu aamen kirikus". Eksponeeritud Kristin Kalamehe lühimängufilm "Igavene tuli", Mirja-Mari Smidti video ja maaliseeria "Kaaluta olek", Allan Tõnissoo videoskulptuur "Kristus", Avangardi (Sandra Jõgeva, Margus Tamm) fotoseeria ja video "Sõda ja rahu". Avamisel Avangardi performance

  17. 1. V kell 19 algab Tartu Sadamateatris...

    Index Scriptorium Estoniae

    2005-01-01

    Tartu Kõrgema Kunstikooli tekstiiliosakonna korraldatud üritus "Projekt: Mood-Performance-Tants". Esineb Viljandi Kultuuriakadeemia tantsutrupp Jaanika Müürsepa juhendamisel. Baby Universali moeetendusel esinevad Maru, Kätlin Kängsepp, Liisi Eesmaa, Jaanika Terasmaa, Ieva Veita, Ilze Adumane jt. Muusikat teevad Kiwa, King-Bit, Fabrique jt.

  18. Homme kell 13 algab Von Krahli teatris...

    Index Scriptorium Estoniae

    2005-01-01

    III rahvusvaheline video ja performance'i festival "Inport 2005", mille on kokku pannud Gert Hatsukov. Loetletud aktsioonide autorid (Eesti: Sandra Jõgeva, Yellow Wolfman [Andrus Joonas], Andres Tenusaar)

  19. Haal alles uit onderzoek (interview met Leo Marcelis en Hans Dagevos)

    NARCIS (Netherlands)

    Kamminga, H.; Marcelis, L.F.M.; Dagevos, H.

    2012-01-01

    In de toekomst zullen tuinbouwbedrijven meer teelt- en consumentenonderzoek op eigen houtje laten uitvoeren. Voor veel ondernemers is dit nieuw. Wetenschappers Leo Marcelis en Hans Dagevos geven tips om zoveel mogelijk nuttige informatie uit onderzoek te halen.

  20. Hans Jonas' Thought on The Ethics of Research on Human Subjects

    African Journals Online (AJOL)

    Dr Olaleye

    Subjects: Implications for Contemporary Medical Research in. Nigeria. Ebeh J.I1 and ... Keywords: Human Research ethics, Nigeria, Hans Jonas. *Author for corresp .... 1998) reported a case of over sixty embryos that were transplanted into ...

  1. Rootsi ja Eesti - kümme aastat koostööd / Hans Lepp

    Index Scriptorium Estoniae

    Lepp, Hans, 1950-

    2003-01-01

    Rootsi Instituudi kultuuri- ja ühiskonnaosakonna direktor Hans Lepp meenutab oma tegevust Rootsi kultuuriatašeena Eestis 1990ndatel aastatel. Ka autori meenutused kohtumisest RRi peadirektori Ivi Eenmaaga, ka rootsi saali asutamisest RRis

  2. Former Netherlands Deputy Prime Minister Hans Dijkstal Leads Delegation to China

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    <正>Hans Dijkstal, former Netherlands deputy prime minister and current chairman of the Board of Atlantic & Pacific Exchange Programme (APEP) of the Netherlands, headed a 12-member goodwill delegation to visit Beijing and Shanghai from May 25 to

  3. The inherent purpose of ontology in ecology: The immutable use of Hans Jonas’s works

    Directory of Open Access Journals (Sweden)

    Raluca Deleanu

    2014-12-01

    Full Text Available Theresa Morris, Hans Jonas’s Ethic of Responsibility: From Ontology to Ecology, Albany, NY: State University of New York Press, SUNY Series in Environmental Philosophy and Ethics, 2013, 236 p.

  4. Det var ikke hans krop, der lå i graven

    DEFF Research Database (Denmark)

    Nord, Ane Marie

    2011-01-01

    I 14 år lagde Norma blomster ved det gravsted, hun troede indeholdt hendes bror. Det gjorde det ikke.Hun drømmer om at dø med vished om, at hans jordiske rester er fundet, om at have et gravsted at lægge blomster ved, og om at se de skyldige for hans død dømt. Men det er en drøm, der nok tvivlsomt...

  5. Tallinna linnaelu kajastumine raehärra Hans Rotgersi märkmetes / Tiina Kala

    Index Scriptorium Estoniae

    Kala, Tiina

    2008-01-01

    Hans Rotgersi aktiivne tegutsemisperiood hõlmab 15. sajandi viimase ja 16. saj. esimese veerandi. Kõige ulatuslikuma kirjaliku pärandi on ta endast maha jätnud Niguliste kiriku eestseisjana. Niguliste kiriku olulistest daatumitest. Maksujõuliste tallinlaste surma kajastumisest Rotgersi ülestähendustes. Rotgersi käsikirjas säilinud astroloogiliste ja meditsiiniliste soovituste kogust. Hans Rotgersi testamendist.

  6. Det var ikke hans krop, der lå i graven

    DEFF Research Database (Denmark)

    Nord, Ane Marie

    2011-01-01

    I 14 år lagde Norma blomster ved det gravsted, hun troede indeholdt hendes bror. Det gjorde det ikke.Hun drømmer om at dø med vished om, at hans jordiske rester er fundet, om at have et gravsted at lægge blomster ved, og om at se de skyldige for hans død dømt. Men det er en drøm, der nok tvivlsom...

  7. Porcelain in the Ming Dynasty:Cultural and Artistic Exchanges Between Hans and Tibetans

    Institute of Scientific and Technical Information of China (English)

    WuMingdi

    2004-01-01

    As an example of Chinese arts and crafts, porcelain is an important element of Chinese culture. In ancient times, when transport and communications were extremely backward, the continuous flow of porcelain items between Han Chinese and Tibetans played an essential role in their material and cultural life. Put specifically, the close relationship between porcelain and Han-Tibetan cultural and artistic exchanges can be observed as follows:

  8. Minu moto : alati kõrgustesse! Dr. Hans O. A. Koehn, ADDINOL Lube Oil GmbH osanik - 80 / Hans O. A. Koehn ; interv. Mikk Mehide

    Index Scriptorium Estoniae

    Koehn, Hans O. A.

    2006-01-01

    Maailma tippkvaliteediga määrdeaineid tootva Saksa õlifirma Addinol osanik dr. Hans O. A. Koehn on üks juhtivaid isikuid Saksamaa mineraalõli majanduses, tööst õlifirmas Valvoline, edasisest karjäärist ning Addinoli osanikuks saamisest

  9. Plant crop remains from the outer burial pit of the Han Yangling Mausoleum and their significance to Early Western Han agriculture

    Institute of Scientific and Technical Information of China (English)

    YANG XiaoYan; LIU ChangJiang; ZHANG JianPing; YANG WuZhan; ZHANG XiaoHu; L(U) HouYuan

    2009-01-01

    A large amount of carbonized plant remains were discovered in one of the outer burial pits of the Han Yangling Mausoleum, which was built more than 2000 years ago for the Jing Emperor, Liu, Qi (188-141 cal a BC), the fourth emperor of the Western Han Dynasty. The remains are identified by phytolith analysis and macrofossil morphological features. Seeds from foxtail millet (Setaria italica), broomcorn millet (Panicum miliaceum), rice (Oryza sativa) and chenopod (possible Chenopodium giganteum) are identified, suggesting that these four crops might have been the staple plant foods in the capital area (Guanzhong area), Shaanxi Province during the Early Western Han Dynasty. Chenopods were often considered as weeds since they have only been rarely found as carbonized seeds in prehistoric sites. This is the first time such a large amount of seeds has been found at a site, which provides strong material evidence for chenopod cultivation with a long history in China. Wheat was thought to be promoted and popularized in the Guanzhong area since the Wu Emporor, Liu, Che (156-87 cal a BC), the fifth emperor of the Western Han Dynasty. No wheat was found at this site, which supports the historical document record that wheat was still secondary in the diet and agrarian economy before the Wu Emperor's reign.

  10. Minu moto : alati kõrgustesse! Dr. Hans O. A. Koehn, ADDINOL Lube Oil GmbH osanik - 80 / Hans O. A. Koehn ; interv. Mikk Mehide

    Index Scriptorium Estoniae

    Koehn, Hans O. A.

    2006-01-01

    Maailma tippkvaliteediga määrdeaineid tootva Saksa õlifirma Addinol osanik dr. Hans O. A. Koehn on üks juhtivaid isikuid Saksamaa mineraalõli majanduses, tööst õlifirmas Valvoline, edasisest karjäärist ning Addinoli osanikuks saamisest

  11. An Unknown Tradition of Han Chinese Conversions to Tibetan Buddhism:Han Chinese Incarnate Lamas and Parishioners of Tibetan Buddhist Monasteries in Amdo

    Institute of Scientific and Technical Information of China (English)

    Gray Tuttle

    2013-01-01

    AbstrActThis article examines Han Chinese who has historically practiced Tibetan Buddhism in the Qinghai-Gansu border region. The main primary sources were published in the 1990s, based on surveys by Chinese social scientists who were sent around in the 1950s to collect data on Tibetan Buddhist institutions as well as additional independent surveys from the 1980s and my own site visits in 2006. On the basis of these sources, I argue that there are at least 100,000 and probably as many as 200,000 Han Chinese on the borders of Qinghai and Gansu (part of the Amdo cultural region for Tibetans) practicing Tibetan Buddhism, following traditions that seem to have been in place for centuries. I also discuss the sixteen historic cases of Han Chinese reincarnate lamas and the over one hundred monasteries in this region affiliated with Han Chinese. Finally, I note the sectarian affiliations (jiaopai: Nyingma, Geluk, etc.) and religious practices of these Chinese communities practicing Tibetan Buddhism.

  12. Quantitative Analysis and Comparison of BMI among Han, Tibetan, and Uygur University Students in Northwest China

    Directory of Open Access Journals (Sweden)

    Bai Jingya

    2013-01-01

    Full Text Available Objectives. To fully analyze and compare BMI among Han, Tibetan, and Uygur university students, to discuss the differences in their physical properties and physical health, and thus to provide some theoretical suggestions for the improvement of students’ physical health. Methods. The cross-sectional random cluster sampling was used to investigate 10103 Han, Tibetan, and Uygur university students, aged 20–24 in Northwest China, and their height and weight were measured to calculate BMI. The BMI classification criteria for Chinese established by Work Group on Obesity in China (WGOC were used for screening. Results. Han, Tibetan, and Uygur university students show low obesity rates but high overweight rates. Han, Tibetan, and Uygur university students present a high rate of underweight, normal weight, and overweight, respectively. Female Han students show higher underweight and normal weight rates, but lower overweight and obesity rates, than male Han students. Female Tibetan students show higher normal weight rate, but lower overweight and obesity rates, than male Tibetan students. BMI increases with age for male students but decreases with age for female students. Male Uygur students show higher obesity rate than female Uygur students. Tibetan and Uygur university students have higher BMI than other minorities in South China.

  13. Prevalence of and risk factors for gallstones in Uighur and Han Chinese

    Science.gov (United States)

    Zhu, Li; Aili, Aikebaier; Zhang, Cheng; Saiding, Aili; Abudureyimu, Kelimu

    2014-01-01

    AIM: To perform a single-centre survey of the prevalence of and possible risk factors for gallstones in Uighur and Han Chinese. METHODS: Complete medical data for 9455 patients were collected from the medical centre of our hospital, and the overall prevalence of gallstones as well as the prevalence in different ethnic groups was studied. The risk factors for gallstones in different ethnic groups were identified in a univariate analysis, and variables with statistical significance were analysed by unconditional multiple logistic regression, to primarily explore the similarities and differences in gallstone risk factors between different ethnic groups. RESULTS: The prevalence of gallstones was significantly higher in the Uighur population than in the Han population (22.87% vs 11.64%, P gallstones based on the different ethnic areas revealed that age was a risk factor for gallstones in both groups; triglycerides, body-mass index (BMI) and high-density lipoprotein were risk factors for gallstones in the Han population, while total cholesterol (TC), gender and fatty liver were risk factors in the Uighur population. The Uighur patients were older than the Han patients, and had higher BMI, TC, low-density lipoprotein, female rate and fatty liver rate, while the incidence of hypertension was lower than that in the Han patients. CONCLUSION: The prevalence of and risk factors for gallstones differ between the Uighur and Han populations. PMID:25356055

  14. Implicit trust between the Uyghur and the Han in Xinjiang, China.

    Directory of Open Access Journals (Sweden)

    Shen Zhang

    Full Text Available Trust is a vital lubricant that increases the sense of security in social interactions. In this study, we investigated the intergroup trust between the Uyghur and the Han, the two largest ethnic groups in Xinjiang, China, with a Go/No-Go Association Task. Specifically, we instructed Uyghur and Han participants to respond to ethnic faces (Uyghur vs. Han and trust/distrust words and measured the strength of the automatic associations between the faces and words for both in-group and out-group pairs. As expected, both ethnic groups showed implicit in-group trust and out-group distrust, but the Han group demonstrated stronger in-group trust and out-group distrust toward the Uyghur than the Uyghur group toward the Han. However, the magnitude of distrust of the Han toward the Uyghur was small to medium as compared with that reported by other intergroup relationship research. In addition, participant geographic location was associated with out-group distrust. These findings offer implications for developing effective strategies to encourage trust between conflicting groups.

  15. Prevalence of Diabetes and Associated Factors in the Uyghur and Han Population in Xinjiang, China

    Directory of Open Access Journals (Sweden)

    Haiying Gong

    2015-10-01

    Full Text Available Objective: To estimate the prevalence of diabetes and identify risk factors in the Uyghur and Han population in Xinjiang, China. Methods: A cross-sectional study in urban and rural areas in Xinjiang, including 2863 members of the Uyghur population and 3060 of the Han population aged 20 to 80 years, was conducted from June 2013 to August 2013. Data on fasting plasma glucose (FPG and personal history of diabetes were used to estimate the prevalence of diabetes. Data on demographic characteristics, lifestyle risk factors, and lipid profiles were collected to identify risks factors using the multivariate logistic regression model. Results: In urban areas, the age- and gender-standardized prevalence of diabetes was 8.21%, and the age- and gender-standardized prevalence of diabetes was higher in the Uyghur population (10.47% than in the Han population (7.36%. In rural areas, the age- and gender-standardized prevalence of diabetes was 6.08%, and it did not differ significantly between the Uyghur population (5.71% and the Han population (6.59%. The results of the multivariate logistic regression analysis showed that older age, obesity, high triglycerides (TG, and hypertension were all associated with an increased risk of diabetes in the Uyghur and Han population. Urban residence and low high-density lipoprotein cholesterol (HDL-C were associated with an increased risk of diabetes in the Uyghur population. Being an ex-drinker was associated with an increased risk of diabetes and heavy physical activity was associated with a decreased risk of diabetes in the Han population. Conclusions: Our study indicates that diabetes is more prevalent in the Uyghur population compared with the Han population in urban areas. Strategies aimed at the prevention of diabetes require ethnic targeting.

  16. Attachment and sibling rivalry in Little Hans: the fantasy of the two giraffes revisited.

    Science.gov (United States)

    Wakefield, Jerome C

    2007-01-01

    Freud's interpretation of Little Hans's "phantasy of the two giraffes" is pivotal to his oedipal analysis that Hans has inchoate desires for sexual intercourse with his mother. Bowlby argued that Freud's focus on his oedipal theory led him to ignore preoedipal attachment-related factors that have equal plausibility in explaining the clinical data. However, Bowlby did not attempt to apply the attachment perspective to the interpretation of Hans's fantasies that form the core of the case material. A microanalysis of Hans's giraffe fantasy and the evidence used to support Freud's claims about it yields an attachment-based sibling rivalry account arguably of greater explanatory power than the oedipal account. Consistent with Bowlby's hypothesis, the evidence suggests that Hans's giraffe fantasy is about the sibling rivalry triangle involved in caregiver attachment access, rather than (or in addition to) the oedipal triangle. The issue of multiple levels of meaning and the methodological challenges raised by multiple determination is also considered. The giraffe fantasy's attachment-theoretic explanation encourages a rethinking of this classic case and strengthens Bowlby's claim that the case is fruitfully viewed from an attachment perspective.

  17. Hydrogeochemical and isotopic investigations of the Han River basin, South Korea

    Science.gov (United States)

    Ryu, Jong-Sik; Lee, Kwang-Sik; Chang, Ho-Wan

    2007-10-01

    SummaryThe Han River, the largest river in South Korea draining approximately 26,000 km 2, comprises two major tributaries: the North and the South Han Rivers. Seasonal and spatial variations in the major ion chemistry and isotope compositions of the Han River were monitored for one year at 14-23 locations, covering about 80% of the entire drainage basin. Compared to the South Han River (SHR), the North Han River (NHR) was much lower in total dissolved solids (TDS), Sr, and major ion concentrations, but higher in Si concentration, δ 34S SO 4 values, and 87Sr/ 86Sr ratios. These observations suggest strong influence of prevailing rock types in the drainage basins on the chemical and isotopic compositions of the river waters. These are silicate rocks in the NHR basin and carbonate rocks in the SHR basin. The headwaters of the NHR basin, where several flood control dams have been constructed, show enrichment in deuterium and oxygen-18, indicating evaporative loss. The δ 34S SO 4 data suggest dissolved sulfates in the NHR and SHR are mostly derived from atmospheric deposition, and variable mixtures of atmospheric deposition and sulfide oxidation, respectively. The 87Sr/ 86Sr ratios are much higher in the NHR (0.71793-0.72722) than in the SHR (0.71495-0.71785) with one exception, indicating weathering of Precambrian and Mesozoic granitic rocks and marine carbonates, respectively.

  18. Comparative Analysis of Gut Microbiota of Native Tibetan and Han Populations Living at Different Altitudes.

    Directory of Open Access Journals (Sweden)

    Kang Li

    Full Text Available The factors driving the composition of gut microbiota are still only partly understood but appear to include environmental, cultural, and genetic factors. In order to obtain more insight into the relative importance of these factors, we analyzed the microbiome composition in subjects of Tibetan or Han descent living at different altitudes. DNA was isolated from stool samples. Using polymerase chain reaction methodology, the 16S rRNA V1-V3 regions were amplified and the sequence information was analyzed by principal coordinates analysis and Lefse analyses. Contrasting the Tibetan and Han populations both living at the 3600 m altitude, we found that the Tibetan microbiome is characterized by a relative abundance of Prevotella whereas the Han stool was enriched in Bacteroides. Comparing the microbiome of Han stool obtained from populations living at different altitudes revealed a more energy efficient flora in samples from those living at higher altitude relative to their lower-altitude counterparts. Comparison of the stool microbiome of Tibetan herders living at 4800 m to rural Tibetans living at 3600 m altitude shows that the former have a flora enriched in butyrate-producing bacteria, possibly in response to the harsher environment that these herders face. Thus, the study shows that both altitude and genetic/cultural background have a significant influence on microbiome composition, and it represents the first attempt to compare stool microbiota of Tibetan and Han populations in relation to altitude.

  19. Analysis of 24 Y-STR haplotype data in a Chinese Han population from Guangdong Province.

    Science.gov (United States)

    Wang, Ying; Liu, Chao; Zhang, Chu-chu; Li, Ran; Liu, Hong; Ou, Xue-ling; Li, Hai-xia; Sun, Hong-yu

    2016-05-01

    In this study, we investigated the genetic polymorphisms of 24 Y-chromosomal short tandem repeat (Y-STR) loci in 885 unrelated Chinese Han male individuals from Guangdong Province, using a domestic AGCU Y24 STR kit. A total of 878 different haplotypes were observed at the 24 Y-STR loci; among them, 871 haplotypes were unique and 7 haplotypes occurred twice. The overall haplotype diversity was 0.99998 and the discrimination capacity was 99.2%. The gene diversity values ranged from 0.4354 at DYS438 to 0.9606 at DYS385a/b. Population relationships between the Guangdong Han population and seven other published Chinese populations were evaluated by Rst values and visualized in a two multi-dimensional scaling plot. The results showed the 24 Y-STR loci are highly polymorphic in Guangdong Han population and of great value in forensic application.

  20. Relation of Plasma Uric Acid Levels and the Lipid Parameters in Han and Uygur Ethnicity

    Institute of Scientific and Technical Information of China (English)

    Sun Yuping; Yao Hua; Yao Wenhai; Li Qing; You Lan; Wang Qiuyun; Jiang Yan

    2006-01-01

    Objectives Hyperuricemia is a common finding in hypertension and hyperlipidemia,they are all correlated to cardiovascular diseases. The aim of this study was to find the relationship of uric acid and plasma lipid parameters of Han and Uygur ethnicity in Xinjiang. Methods This cross-sectional health examination survey was based on a population random sample from the Urumchi, It included 1166 subjects aged from 20 to 70 years. Serum biochemical testing by Automatic Analyzer (HITACHI 7600-010).Results The uric acid in Han was higher than in Uygur(P< 0.05), men were higher than women in two ethnicities; For lipid parameters men were higher than women, in TG and HDL women were higher than in men in two ethnicity (P < 0.05). Serum uric acid was strongly related to serum triglycerides in Han as well as Uygur ethnicity ( P < 0.001); Compared with the normal group, UA, TG, CHOL, VLDL had ascending trend and HDL had descending trend (P <0.05 ) among groups in Han and Uygur ethnicity,especially Hyperuricemia-hypertriglyceridemia group,uric acid and most some lipid parameters was higher than Hyperuricemia and hypertriglyceridemia group,The prevalence of different groups in Han and Urgur was significantly different (P < 0.05). Conclusions This study shows that the UA and some lipid parameters are different in Han and Uygur ethnicity and show sexual difference; serum uric acid is markedly related to serum triglycerides; Hyperuricemia and hypertriglyceridemia show cooperated effect in uric acid and most lipid parameters. Considering the growing incidence of the potential link between hyperuricemia/hypertriglyceridemia and cardiovascular diseases, more emphasis should be put on the evolving prevalence of hyperuricemia and hypertriglyceridemia in Xinjiang.

  1. Study on the Brocades of Han Dynasty in Philadelphia Museum of Art

    Institute of Scientific and Technical Information of China (English)

    屠恒贤

    2004-01-01

    The brocades (jin 锦) in Han Dynasty is very precious for the study of the history of ancient Chinese textiles. This paper introduces the study on the brocades of Han Dynasty, which excavated from the tumuli of the ancient nomadic tribe "Xiong-nu" (Hun 匈奴) in the Noin-Ula Mountains in Mongolia. The detailed analyses of the brocades in the collection of Philadelphia Museum of Art are given in this paper and a logical, reasonable conjecture for ancient weaving technology is proposed.

  2. Prof. CHEN Han-ping: A Thinker in Principles and Practice of Acupuncture-moxibustion

    Institute of Scientific and Technical Information of China (English)

    杨永清; 王宇; 尹磊淼

    2010-01-01

    The Thinker (Le Penseur) is known as the masterpiece of Auguste Rodin, a distinguished French sculptor, signifying the intellectual activity and creativity of human being. Having put forward a way of "viewing the Earth from the Moon" in developing preclinical and clinical studies of acupuncture, Prof. CHEN Han-ping brought about imaginations to acupuncture scholars with his ideas on the soul, principle, skills and orientations of acupuncture. He deserves the title of "the thinker in principles and practice of acupuncture"[1-3]. The academic ideas of Prof. CHEN Han-ping are now summarized as follows.

  3. Scientific Bronze Casting Reconstruction of Zhang Heng's Seismograph from the Eastern Han Dynasty

    Institute of Scientific and Technical Information of China (English)

    Hu Chunliang

    2010-01-01

    @@ Commissioned by the state Task Force for scientific reconstruction of Zhang Heng's seismograph, the "Eastern Han Zhang Heng's seismograph" was successfully cast on August 5, 2008 at Shanxi Yuda Group, a national cultural industry demonstration base. After sophisticated assembly and debugging,the 1.7 m tall reconstructed Zhang Heng's seismograph was displayed at the Science and Technology Museum of China in August 2009,making the Eastern Han Zhang Heng's seismograph which had been lost for thousands of years reemerge in the world.

  4. Genetic determination of the enhanced drought resistance of rice maintainer HuHan2B by pedigree breeding.

    Science.gov (United States)

    Wei, Haibin; Feng, Fangjun; Lou, Qiaojun; Xia, Hui; Ma, Xiaosong; Liu, Yunhua; Xu, Kai; Yu, Xinqiao; Mei, Hanwei; Luo, Lijun

    2016-11-17

    The ongoing deficit of fresh water resource in rice growing regions has made the selection of water-saving and drought-resistance rice (WDR) a crucial factor in developing sustainable cultivation. HuHan2B, a new japonica maintainer for WDR breeding, had the same yield potential as recurrent parent HanFengB but showed improved drought resistance in fields. We investigated the genomic content accumulation and candidate genes passed from parent to offspring using the genomic and transcriptomic approaches. The genomic constitution indicated that the genetic similarity was 84% between HuHan2B and HanFengB; additionally, 7,256 genes with specific alleles were inherited by HuHan2B from parents other than HanFengB. The differentially expressed genes (DEGs) under drought stress showed that biological function was significantly enriched for transcript regulation in HuHan2B, while the oxidation-reduction process was primarily enriched in HanFengB. Furthermore, 36 DEGs with specific inherited alleles in HuHan2B were almost involved in the regulatory network of TFs and target genes. These findings suggested that major-effect genes were congregated and transformed into offspring in manner of interacting network by breeding. Thus, exploiting the potential biological function of allelic-influencing DEGs would be of great importance for improving selection efficiency and the overall genetic gain of multiple complex traits.

  5. Kinetics, mechanisms, and influencing factors on the treatment of haloacetonitriles (HANs) in water by two household heating devices.

    Science.gov (United States)

    Shi, Wendong; Wang, Lei; Chen, Baiyang

    2017-04-01

    Haloacetonitriles (HANs) are a group of nitrogenous disinfection by-products (DBPs) commonly found in treated water with potential carcinogenic, cytotoxic, and genotoxic risks. In order to control HANs and understand their real intake levels by people via drinking water, this study evaluated a list of structural, operational, and environmental factors affecting the treatment of HANs by two domestic heating devices, i.e., an electric boiler and a microwave oven. Results show that the concentrations of HANs decreased exponentially over time with increasing temperature, water turbulence, and bubbles, and the phenomena were most likely due to a combined effect of volatilization and hydrolysis. Among HANs, the lability increased with increasing halogenation degrees (i.e., tri- > di- > mono- HANs) yet decreasing halogen molecular weights (i.e., Cl- > Br- > I- HANs); such trends were well captured by quantitative structure activity relationship models (R(2) = 0.99). Operational factors played critical roles in controlling HANs too, including the rate of heating, water volume, water temperature at time of pouring, cooling method, and capping condition, suggesting that people could benefit from proper handling methods and procedures. In addition, HANs added to tap water exhibited higher removals than those added to ultrapure water, probably because of the presence of free chlorine in tap water. Copyright © 2017 Elsevier Ltd. All rights reserved.

  6. Meeting Held for the Publication of Biography of Han Xu——Experience of a Diplomat

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    <正>A meeting for the publication of the Book Biography of Han Xu--Experience of a Diplomat was held in the auditorium of the CPAFFC on September 20. Chen Haosu, president of the CPAFFC, and Wang Chengjia, president of the World Affairs Press, co-chaired the meeting. About

  7. Carvacrolreiches Oregano-Öl als Futterzusatz: Interview met Hans van der Mheen

    NARCIS (Netherlands)

    Grohs, Birgit; Mheen, van der H.J.C.J.

    2011-01-01

    In dit interview met Hans van der Mheen van het PPO-agv te Lelystad worden de mogelijkheden van het gebruik van etherische olie gewonnen uit oregano; origanum vulgare en origanum heracleoticum, geteeld in Nederland besproken. De olie kan gebruikt worden in voer voor pluimvee en varkens. Gezocht word

  8. Association of tumor necrosis factor polymorphisms with susceptibility to ulcerative colitis in Chinese Han population

    Institute of Scientific and Technical Information of China (English)

    曹倩

    2006-01-01

    Objective To investigate the association between tumor necrosis factor(TNF) promoter polymorphisms and susceptibility to ulcerative colitis (UC) in the Chinese Han population. Methods Blood samples from 110 unrelated UC patients and 292 healthy controls from Zhejiang Province, Eastern China were studied. Genotyping for 6 common TNF promoter polymorphisms (TNF-

  9. Book Review: Zöllner, Hans-Bernd, The Beast and the Beauty: ...

    Directory of Open Access Journals (Sweden)

    Grit Grigoleit

    2012-01-01

    Full Text Available Book Review of the monograph: Zöllner, Hans-Bernd (2012, The Beast and the Beauty: The History of the Conflict between the Military and Aung San Suu Kyi in Myanmar, 1988–2011, Set in a Global Context Berlin: regiospectra Verlag, ISBN: 978-3-9401-3244-4, 592 pages

  10. Collaboration, Reputation, and Ethics in American Academic Life: Hans H. Gerth and C. Wright Mills.

    Science.gov (United States)

    Oakes, Guy; Vidich, Arthur J.

    Using the collaboration between sociologist C. Wright Mills and Hans H. Gerth and their studies of the work of Max Weber as a point of departure for a sustained discussion of academic ethics, this book explores how concealment, secrecy, and deception contribute to the building of academic reputation and how the balance of knowledge and power in a…

  11. Brief Report: No Increase in Criminal Convictions in Hans Asperger's Original Cohort

    Science.gov (United States)

    Hippler, Kathrin; Viding, Essi; Klicpera, Christian; Happe, Francesca

    2010-01-01

    Hans Asperger originally used the term "autistic psychopathy" to describe his patients on the autism spectrum, leading to a possible confusion with psychopathic disorder and delinquent behaviour. We conducted a penal register search for 177 former patients of Asperger's clinic with a childhood diagnosis of "autistic…

  12. Quantitative Analysis of Intestinal Flora of Uygur and Han Ethnic Chinese Patients with Ulcerative Colitis

    Directory of Open Access Journals (Sweden)

    Ping Yao

    2016-01-01

    Full Text Available Aim. To study the correlation between intestinal flora and ulcerative colitis by analyzing the abundance of Bacteroides, Fusobacterium, Clostridium, Bifidobacterium spp., and Faecalibacterium prausnitzii in the intestinal of ulcerative colitis (UC patients and healthy controls with Uygur and Han ethnic. Methods. Bacterial genomic DNA was extracted from fecal samples and analyzed with real-time fluorescence quantitative polymerase chain reaction (PCR to identify the abundance of Bacteroides, Fusobacterium, Clostridium, Bifidobacterium spp., and Faecalibacterium prausnitzii. Results. The samples from UC patients, Uygur and Han ethnic combined, had higher abundance of Bacteroides (P=0.026 but lower Clostridium (P=0.004, Bifidobacterium spp. (P=0.009, and Faecalibacterium prausnitzii (P=0.008 than those from healthy controls. Among UC patients, Bacteroides population was raised in acute UC patients (P≤0.05, while the abundance of Clostridium, Bifidobacterium spp., Fusobacterium, and Faecalibacterium prausnitzii decreased (P≤0.05 compared with the remission. In both UC patients group and control group, no difference was observed in the abundance of these 5 bacteria between the Han and the Uygur group. Conclusions. Variations in the abundance of these five bacterial strains in intestines may be associated with the occurrence of UC in Uygur and Han populations; however, these variations were not associated with ethnic difference.

  13. Hans J. Massaquoi’s Destined to Witness as an Autobiographical Act of Identity Formation

    Directory of Open Access Journals (Sweden)

    Lindhout, Alexandra E.

    2006-01-01

    Full Text Available In his autobiography, Hans J. Massaquoi describes the discrimination he encountered in Nazi Germany and Liberia because of his mixed racial background. Throughout his life Massaquoi had to cope with identity crises. Through the self-therapeutic discourse in the form of his autobiography, however, Massaquoi developed his hybrid transatlantic African American and African German identity.

  14. Brief Report: No Increase in Criminal Convictions in Hans Asperger's Original Cohort

    Science.gov (United States)

    Hippler, Kathrin; Viding, Essi; Klicpera, Christian; Happe, Francesca

    2010-01-01

    Hans Asperger originally used the term "autistic psychopathy" to describe his patients on the autism spectrum, leading to a possible confusion with psychopathic disorder and delinquent behaviour. We conducted a penal register search for 177 former patients of Asperger's clinic with a childhood diagnosis of "autistic psychopathy" or features of the…

  15. Genetic variants at 20p11 confer risk to androgenetic alopecia in the Chinese Han population.

    Directory of Open Access Journals (Sweden)

    Bo Liang

    Full Text Available BACKGROUND: Androgenetic alopecia (AGA is a well-characterized type of progressive hair loss commonly seen in men, with different prevalences in different ethnic populations. It is generally considered to be a polygenic heritable trait. Several susceptibility genes/loci, such as AR/EDA2R, HDAC9 and 20p11, have been identified as being involved in its development in European populations. In this study, we aim to validate whether these loci are also associated with AGA in the Chinese Han population. METHODS: We genotyped 16 previously reported single nucleotide polymorphisms (SNPs with 445 AGA cases and 546 healthy controls using the Sequenom iPlex platform. The trend test was used to evaluate the association between these loci and AGA in the Chinese Han population. Conservatively accounting for multiple testing by the Bonferroni correction, the threshold for statistical significance was P ≤ 3.13 × 10(-3. RESULTS: We identified that 5 SNPs at 20p11 were significantly associated with AGA in the Chinese Han population (1.84 × 10(-11 ≤ P ≤ 2.10 × 10(-6. CONCLUSIONS: This study validated, for the first time, that 20p11 also confers risk for AGA in the Chinese Han population and implicated the potential common genetic factors for AGA shared by both Chinese and European populations.

  16. Odavpoodide kett soetas suure krundi Viljandi südamesse / Hans Väre

    Index Scriptorium Estoniae

    Väre, Hans, 1979-

    2006-01-01

    Saksa kaubandusketi Lidl Eesti tütarfirma ostis kaubanduskeskuse rajamiseks Viljandi bussipargi kinnistu. Lidl taotleb kvartali detailplaneeringu algatamist eesmärgiga muuta kruntide piire, määrata ehitusõigus ja liikluskorraldus. Vanemarhitekt Leelo Saare selgitused. Vaata ka Hans Väre kommentaari "Mis tuleb bussiparki?" lk. 5

  17. Bronzino and a bronze boar. Hans Christian Andersen and Stendhal in nineteenth-century Florence

    NARCIS (Netherlands)

    Klerck, A.R. de

    2015-01-01

    Bronzino e il porcellino: Hans Christian Andersen e Stendhal nella Firenze del XIX secolo La storia dell’arte dell’Ottocento non sembra aver avuto particolarmente a cuore gli artisti italiani delle generazioni successive ai grandi maestri rinascimentali, quali Raffaello e Michelangelo. Così, ad

  18. 'Presence' of the past in the presence (Hans Ulrich Gumbrecht, Eelco Runia)

    NARCIS (Netherlands)

    ter Schure, L

    2006-01-01

    In recent writings historian Eelco Runia (Groningen) and literary theorist Hans Ulrich Gumbrecht (Stanford) have introduced the notion of presence, a new and promising way of thinking about history. Although there are differences between the two authors, both think of presence as the antithesis of '

  19. Quantitative Analysis of Intestinal Flora of Uygur and Han Ethnic Chinese Patients with Ulcerative Colitis.

    Science.gov (United States)

    Yao, Ping; Cui, Min; Wang, Haikun; Gao, Hongliang; Wang, Lei; Yang, Tao; Cheng, Yongbo

    2016-01-01

    Aim. To study the correlation between intestinal flora and ulcerative colitis by analyzing the abundance of Bacteroides, Fusobacterium, Clostridium, Bifidobacterium spp., and Faecalibacterium prausnitzii in the intestinal of ulcerative colitis (UC) patients and healthy controls with Uygur and Han ethnic. Methods. Bacterial genomic DNA was extracted from fecal samples and analyzed with real-time fluorescence quantitative polymerase chain reaction (PCR) to identify the abundance of Bacteroides, Fusobacterium, Clostridium, Bifidobacterium spp., and Faecalibacterium prausnitzii. Results. The samples from UC patients, Uygur and Han ethnic combined, had higher abundance of Bacteroides (P = 0.026) but lower Clostridium (P = 0.004), Bifidobacterium spp. (P = 0.009), and Faecalibacterium prausnitzii (P = 0.008) than those from healthy controls. Among UC patients, Bacteroides population was raised in acute UC patients (P ≤ 0.05), while the abundance of Clostridium, Bifidobacterium spp., Fusobacterium, and Faecalibacterium prausnitzii decreased (P ≤ 0.05) compared with the remission. In both UC patients group and control group, no difference was observed in the abundance of these 5 bacteria between the Han and the Uygur group. Conclusions. Variations in the abundance of these five bacterial strains in intestines may be associated with the occurrence of UC in Uygur and Han populations; however, these variations were not associated with ethnic difference.

  20. Meeting Held for the Publication of Biography of Han Xu——Experience of a Diplomat

    Institute of Scientific and Technical Information of China (English)

    OurStaffReporter

    2004-01-01

    Ameeting for the publication of the Book Biography of Han Xu——Experience of a Diplomat was held in the auditorium of the CPAFFC on September 20. Chen Haosu, president of the CPAFFC, and Wang Chengjia, president of the World Affairs Press, co-chaired the meeting. About 60 former colleagues, subordinates,

  1. Prevalence and Risk Factors of Infertility for Han, Uygur, and Kazakh Ethnicities in Xinjiang Rural Residents.

    Science.gov (United States)

    Zhao, Jing; Wang, Songfeng; Gao, Qi; Cai, Xia; La, Xiaolin

    2015-01-01

    To estimate the prevalence and associated factors of current infertility for Han, Uygur, and Kazakh ethnicities in Xinjiang rural residents. Chinese Uygur, Kazakh, and Han populations represent > 90% of the total population of the Xinjiang Uygur Autonomous Region, and their customs, culture, and food consumption are different. The effect of ethnic differences on infertility risk factors is rarely studied. A cross-sectional study of 5,086 married and common-law couples, with a female partner aged 18-49, living in Hami, Kuche, or Xinyuan counties in Xinjiang, China. General information for the study subjects, including demographic characteristics, life customs, sexual history, history of contraception use, and history of disease, was collected by questionnaire. General health, gynecologic examinations, and sociodemographic characteristics were also carried out. A total of 5,086 females from Xinjiang Province were surveyed, including 493 with infertility. The standardized prevalence rate of infertility was 9.7% (95% CI 8.9-10.5), and the prevalence of infertility in Han, Uygur, and Kazakh ethnicities was 6.8% (95% CI 5.7-7.9), 10.9% (95% CI 8.0-13.8), and 10.1% (95% CI 7.4-12.8), respectively. The present study suggests that the prevalence of infertility was lower in the Han as compared to the Kazakh and Uygur ethnicities.

  2. Milline oli teie esimene töökoht? / Raivo Vare, Rein Lang, Hans H Luik

    Index Scriptorium Estoniae

    Vare, Raivo, 1958-

    2002-01-01

    Oma esimest töökohta meenutavad Tallinna abilinnapea, AS-i Trio LSL nõukogu esimees Rein Lang, AS-i Pakterminal juhatuse esimees Raivo Vare ja Eesti Ekspressi vastutav väljaandja ning Ekspress Grupi nõukogu liige Hans H. Luik

  3. Looduskaitse ülistamise ja ignoreerimise keerulisel teel / Hans Trass ; interv. Toomas Kukk

    Index Scriptorium Estoniae

    Trass, Hans, 1928-

    2007-01-01

    Eesti looduskaitse ja looduse uurimise hetkeseisust. 17. aug. 2006 vastu võetud määrusest Lääne-Eesti saarestiku biosfääri kaitseala kehtetuks tunnistamise kohta, mis näitab, et Eesti ignoreerib UNESCO loodud biosfääri kaitseala programmi. Lisatud Hans-Voldemar Trassi eluloolised andmed

  4. My Practice Report to “Han Suyin Award for Young Translators”

    Institute of Scientific and Technical Information of China (English)

    何霞

    2016-01-01

    As we all know, "Translation is the communication of the meaning of a source-language text by means of an equivalent target-language text." This report is going to analyze the E-C and C-E translation process of two works in "Han Suyin Award for Young Translators".

  5. The Relevance of Hans-Georg Gadamer's Concept of Tradition to the Philosophy of Education

    Science.gov (United States)

    Leiviskä, Anniina

    2015-01-01

    In this article, Anniina Leiviskä argues that the educational relevance of Hans-Georg Gadamer's concept of tradition has remained unacknowledged because of the conservatism that has been associated with Gadamer's hermeneutics, particularly his notion of tradition. Therefore, Leiviskä seeks to reveal the reflective, nonconservative nature of…

  6. A Gnostic Critic of Modernity: Hans Jonas from Existentialism to Science

    DEFF Research Database (Denmark)

    Cahana, Jonathan

    2017-01-01

    This article addresses the ways in which the German-Jewish philosopher Hans Jonas (1903–1993) employed Gnosticism in his philosophical critique of modernity. Far from treating it as an “antiquarian concern” or attempting to “overcome” it, I argue that Jonas continuously used Gnosticism, including...

  7. ANALYSIS ON GENETIC POLYMORPHISM OF 6 STR LOCI ON CHROMOSOME 12 IN CHINESE HAN POPULATION

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    Objective To analyze the genetic polymorphism of 6 STR loci (D12S358, D12S1675, D12S1663, D12S1697, D12S1725 and D12S1613) on chromosome 12 in Chinese Han population. Methods EDTA-blood specimens were collected from 153 unrelated individuals of Chinese Han population in Shaanxi province. Allele and genotype frequencies for the 6 STR loci were estimated and statistical parameters of polymorphism were calculated. Results 8 alleles and 18 genotypes, 10 alleles and 17 genotypes, 9 alleles and 15 genotypes, 12alleles and 29 genotypes, 12 alleles and 31 genotypes, 8 alleles and 11 genotypes were observed at D12S358, D12S1675, D12S1663, D12S1697, D12S1725 and D12S1613, respectively. No deviations of the observed allele frequency from Hardy-weinberg equilibrium expectations were found for any of these loci. The Heterozygotes of these 6 loci were 78.89%, 66.10%, 54.95%, 79.10%, 71.98% and 59.48%, respectively. It indicated the high genetic polymorphism of the loci in Chinese Han population. Conclusion The 6 STR loci belonged to the genetic marker system of high discriminutesation and high information in Chinese Han population and can be used in the study of gene-related diseases.

  8. Epidemiology Investigation of stroke among Mongolian and Han population aged over 45 in Inner Mongolia.

    Science.gov (United States)

    Zhang, Chunyu; Lan, Tian; Zhe, Yan; Hu, Baolige; Zhang, Guohua; He, Juan; Wang, Zhiguang; Jiang, Mingfang; Hu, Riletemuer

    2017-04-04

    To discuss the status of epidemiology of stroke in the Mongolian and Han population aged over 45 years and to understand the treatment and prevention of stroke. Data collected on stroke populations aged over 45 years in the six areas in Inner Mongolia were analyzed by using stratified multi-stage cluster sampling. The prevalence rate of stroke in patients aged over 45 years in Inner Mongolia was 4.62%. The stroke prevalence rate increased with age in both males and females, the Han and Mongolian populations, and was higher in males than in females in Inner Mongolia. The prevalence rate of stroke in the Mongolian population was higher than in the Han population. The incidence rate of stroke in patients aged over 45 years in Inner Mongolia was 0.28%, of which the rate of relapsed ischemic stroke was 23.29%. The proportion of ischemic stroke in the stroke patients was higher than hemorrhagic stroke. The prevalence and incidence rates of stroke in patients aged over 45 years in Inner Mongolia were high. The prevalence rate of stroke in both the Han population and the Mongolian population increased with age. Ischemic stroke was the major form of stroke.

  9. Bronzino and a bronze boar. Hans Christian Andersen and Stendhal in nineteenth-century Florence

    NARCIS (Netherlands)

    Klerck, A.R. de

    2015-01-01

    Bronzino e il porcellino: Hans Christian Andersen e Stendhal nella Firenze del XIX secolo La storia dell’arte dell’Ottocento non sembra aver avuto particolarmente a cuore gli artisti italiani delle generazioni successive ai grandi maestri rinascimentali, quali Raffaello e Michelangelo. Così, ad ese

  10. Antisocial Behavior in Children and Hans Eysenck's Biosocial Theory of Personality: A Review.

    Science.gov (United States)

    Kemp, Dawn E.; Center, David B.

    This paper examines antisocial behavior in children and youth in relation to the biosocial personality theory of Hans Eysenck. It explains Eysenck's theory, which includes a significant role for biological factors in the development of antisocial behavior. The theory holds that three temperament traits--Psychoticism (P), Extroversion (E), and…

  11. Comparison of the Perception of English Learning Between Ethnic Group Students and Han Students

    Institute of Scientific and Technical Information of China (English)

    沈映梅

    2013-01-01

    This paper has analyzed the discrepancies of the perception of English learning between ethnic students and Han studens in a trilingual language context. The research results will be expected to broaden our understanding of the ethnic group students in the minority regions, and to provide some empirical references and implications for teachers.

  12. The Relevance of Hans-Georg Gadamer's Concept of Tradition to the Philosophy of Education

    Science.gov (United States)

    Leiviskä, Anniina

    2015-01-01

    In this article, Anniina Leiviskä argues that the educational relevance of Hans-Georg Gadamer's concept of tradition has remained unacknowledged because of the conservatism that has been associated with Gadamer's hermeneutics, particularly his notion of tradition. Therefore, Leiviskä seeks to reveal the reflective, nonconservative nature of…

  13. Brief Report: No Increase in Criminal Convictions in Hans Asperger's Original Cohort

    Science.gov (United States)

    Hippler, Kathrin; Viding, Essi; Klicpera, Christian; Happe, Francesca

    2010-01-01

    Hans Asperger originally used the term "autistic psychopathy" to describe his patients on the autism spectrum, leading to a possible confusion with psychopathic disorder and delinquent behaviour. We conducted a penal register search for 177 former patients of Asperger's clinic with a childhood diagnosis of "autistic…

  14. Investigation into Emperors and Officials' Citation from Shi in the Western Han Dynasty and the Eastern Han Dynasty%两汉君臣用《诗》考

    Institute of Scientific and Technical Information of China (English)

    郑利锋

    2011-01-01

    Shi has been introduced from Qin Dynasty to the Western Han Dynasty and the Eastern Han Dynasty. In both dynasties, there has been much citation of it in the order and report of the emperors and officials. Thus two schools appeared in the defined period with Xi'an as the center of Western Han Dynasty and Luoyang the center of Eastern Han Dynasty. The two centers have demonstrated different styles of citation both in the amount and the features of application owing to their different historical periods and different development of social poli- tics, economics and ideological trends, which have reflected developmental changes and histori- cal features of Shi. These differences have manifested the development and completion of the combination of classicality and historicity of Shi and have been the perfect integration of the po- litical citation of Shi in the Chun Qiu period and the textual citation in the Warring States Period%《诗》自先秦传人两汉,在两汉历朝君臣的下诏和上奏中都大量引用到《诗》,它们分别以西汉的长安和东汉的洛阳为中心,俨然形成两个用《诗》集团。由于所处的历史时代不同和不同历史时段社会政治、经济与学术思想发展的差异,这两个用《诗》集团在引用《诗》之“风”、“雅”、“颂”的数量和在诏奏中征引时所呈现出的应用特征,又有不同;而在此中则反映出了《诗》学在两汉时期的发展流变和时代特征,显示了《诗》之经典性与历史性融通的进行和完成,是春秋时期政治用《诗》和战国时期文本用《诗》的完美融合和发展。

  15. Hyperuricemia prevalence and genetic susceptibility of young Han males at an altitude of 4520m

    Directory of Open Access Journals (Sweden)

    Zhong-wei TANG

    2016-10-01

    Full Text Available Objective  To investigate the pathogenic characteristics of hyperuricemia and the correlation between hyperuricemia and the polymorphism of xanthine oxidase (XO in young Han males at an altitude of 4520m. Methods  Two hundred and forty Han Chinese young men, aged 16-36 years (mean 22.1 years, moved to an altitude of 4520m for 0.25-10.8 years (mean 2.3 years, were selected. The general information and physiological index were collected by using questionnaires and routine examination; Fasting venous blood was collected in the morning, serum uric acid and XO concentration were measured, and the rs17038412 polymorphism of XO gene was analyzed. Results  There were 186 hyperuricemia patients (hyperuricemia group in 240 subjects, accounting for 77.5%, and 54 people with normal serum uric acid (normal group, accounting for 22.5%. Compared with normal group, the concentrations of XO and hemoglobin were significantly higher, the blood oxygen saturation significantly lower (P<0.01, and blood uric acid concentration was positively correlated to both hemoglobin level and XO concentration in hyperuricemia group (P<0.01, P<0.001. The frequency of AT genotype was significantly higher in hyperuricemia group than in normal group (P<0.01. Logistic regression analysis showed that the AT genotype was a risk factor for hyperuricemia in the young Han men (OR=3.96, 95%CI 1.42-11.08. Conclusions  Incidence rate of hyperuricemia is high in young Han men. Serum uric acid concentration is positively correlated with the concentrations of XO and hemoglobin. AT genotype at a polymorphic site rs17038412 in XO may be related to the risk of hyperuricemia in the young Han men. DOI: 10.11855/j.issn.0577-7402.2016.10.13

  16. Difference in normal corneal thickness and curvature between Mongolian and Han nationalities

    Institute of Scientific and Technical Information of China (English)

    Hai-Xia; Zhao; Li; Zhang; Wen-Ying; Guan

    2015-01-01

    AIM: To investigate the differences in central corneal thickness(CCT) and curvature in myopic patients with different genders between Mongolian and Han nationalities in the Inner Mongolia region.METHODS: Patients with myopia, among whom 122cases(244 eyes) were Mongolian and 150 cases(300eyes) were Han, were selected. Pentacam was used to measure the corneal curvature, whereas CCT was determined by Pentacam, Orbscan and ultrasound pachymetry.RESULTS: Comparisons of the curvature of men and women in Mongolia showed a significant difference(P <0.05) by comparing of the CCT values measured by three methods in Han and Mongolian in Inner Mongolia, we can draw a conclusion that the CCT values measured by Pentacam are less than the values by Orbscan and ultrasound pachymetry, and there are statistically significant difference in CCT measurement among the instruments except between the Orbscan and ultrasound pachymetry. The CCT values of Mongolians are more than Han people, and the analysis exhibited statistical significance. The CCT values measured by Orbscan in Mongolia of women are more than men, the difference showed statistical significance.CONCLUSION: Corneal curvature in Mongolian females was significantly higher than that in males. However, no significant difference was observed among Han males and females. The CCT values of Mongolian females were higher than those of males. The normal CCT values measured by Pentacam in Mongolian myopic patients were smaller than those obtained by Orbscan or ultrasound. The normal CCT values of Mongolian patients with myopia were higher than those reported for domestic people.

  17. [Gao Jingyi. Han yu yu bei Ou yu yan : Han yu yu Wula'er yu yan ji Yin Ou yu yan tong yuan tan jiu] / Ago Künnap

    Index Scriptorium Estoniae

    Künnap, Ago, 1941-

    2010-01-01

    Arvustus: Gao Jingyi. Han yu yu bei Ou yu yan : Han yu yu Wula'er yu yan ji Yin Ou yu yan tong yuan tan jiu = Chinese language and languages of northern Europe. Beijing : Zhongguo she hui ke xue chu ban she, 2008

  18. [Gao Jingyi. Han yu yu bei Ou yu yan : Han yu yu Wula'er yu yan ji Yin Ou yu yan tong yuan tan jiu] / Ago Künnap

    Index Scriptorium Estoniae

    Künnap, Ago, 1941-

    2010-01-01

    Arvustus: Gao Jingyi. Han yu yu bei Ou yu yan : Han yu yu Wula'er yu yan ji Yin Ou yu yan tong yuan tan jiu = Chinese language and languages of northern Europe. Beijing : Zhongguo she hui ke xue chu ban she, 2008

  19. Personalikonsultant Kai Kell : ROWE-metoodika loob paindlikkuse / Kai Kell ; interv. Tiina Saar

    Index Scriptorium Estoniae

    Kell, Kai

    2008-01-01

    HR lighthouse OÜ consulting vanemkonsultant tutvustab ROWE (Results only work environment) metoodikat, mis tugineb põhimõttele, et tööd saab hinnata ainult töötulemuste järgi, ning selle rakendamise eeliseid ja puudusi ettevõtetes

  20. Personalikonsultant Kai Kell : ROWE-metoodika loob paindlikkuse / Kai Kell ; interv. Tiina Saar

    Index Scriptorium Estoniae

    Kell, Kai

    2008-01-01

    HR lighthouse OÜ consulting vanemkonsultant tutvustab ROWE (Results only work environment) metoodikat, mis tugineb põhimõttele, et tööd saab hinnata ainult töötulemuste järgi, ning selle rakendamise eeliseid ja puudusi ettevõtetes

  1. Remarks on the expert`s opinion by Prof. Hans Schaefer: `Does electrosmog endanger health?`; Zum Gutachten von Professor Hans Schaefer: ``Gefaehrdet Elektrosmog die Gesundheit?``

    Energy Technology Data Exchange (ETDEWEB)

    Mohr, H.

    1995-08-01

    Upon invitation by the Academy of Technology Assessment, Prof. Hans Schaefer, lecturing in physiology at Heidelberg University, established an expert`s opinion on the health hazards of the so-called electrosmog phenomenon. The study takes account of relevant publications up to the end of 1994 and is based mostly on original scientific publications. The methodology and findings of these studies were investigated in a meta-analysis. The article is a slightly abridged version of the comments of the Academy of Technology Assessment on Prof. Schaefer`s expert opinion. (orig./MG) [Deutsch] Im Auftrag der Akademie fuer Technikfolgenabschaetzung hat der Heidelberger Physiologe Professor Hans Schaefer ein Gutachten zur Frage der Gesundheitsgefaehrdung durch den sogenannten Elektrosmog erstellt. Es sollte der momentane Wissensstand durch einen Experten erfasst und metaanalytisch aufgearbeitet werden. Die Studie beruecksichtigt die relevante Literatur bis Ende 1994 und stuetzt sich hauptsaechlich auf wissenschaftliche Originalarbeiten. Methoden und Ergebnisse dieser Arbeiten wurden in einer Metaanalyse evaluiert. Der vorliegende Text ist eine leicht gekuerzte Fassung der Stellungnahme der Akademie fuer Technikfolgenabschaetzung zum Gutachten von Professor Schaefer. (orig./MG)

  2. Para além da autoconsciência moderna: a historiografia de Hans Ulrich Gumbrecht Beyond modern self-consciousness: the historiography of Hans Ulrich Gumbrecht

    Directory of Open Access Journals (Sweden)

    Valdei Lopes de Araujo

    2006-12-01

    Full Text Available Neste artigo, apresento uma análise dos aspectos historiográficos da obra de Hans Ulrich Gumbrecht. Acompanhado o desenvolvimento de sua teoria da modernidade e das conseqüências dessa teoria para a escrita da história e para a auto-consciência disciplinar. Por fim, proponho uma releitura da história da historiografia através dos dois tipos de culturas propostas por Gumbrecht, ou seja, culturas de sentido e culturas de presença. Argumento que mesmo que a historiografia moderna possa ser caracterizada como predominantemente ancorada na produção de sentido, aspectos centrais de sua história só podem ser explicados através de elementos típicos da produção de presença.This paper analyses some historiographical aspects of Hans Ulrich Gumbrecht's work, particularly his theory of modernity and its consequences to the writing of history and its disciplinary self-conscious. Finally, it is proposed a reinterpretation of the history of historiography based on the distinction between cultures of presence and cultures of meaning. It is argued that despite the fact that the elements of meaning are predominant in the constitution of modern historiography, the forces acting in its constitution cannot be explained without typical elements of a culture of presence.

  3. Image and Role of the Queen Mother of the West in Han Grave Art

    Directory of Open Access Journals (Sweden)

    Nataša VAMPELJ SUHADOLNIK

    2015-12-01

    Full Text Available The present article is a detailed study of the image of an ancient Chinese goddess, The Queen Mother of the West, called Xiwangmu 西王母 in Chinese. In the mythological tradition, Xiwangmu is a goddess who possesses the elixir of immortality and dwells in the western paradise, on the magic mountain Kunlun 崑崙. While her image can be found in mural paintings, and on lacquered objects and bronze mirrors, it appears primarily in the form of relief images on the stones and bricks of grave chambers and temples in the Han (206 BCE–220 CE grave complexes. The literary tradition reveals a multifunctional role of the mother, with her many attributes developing in accordance with the changing values of social and mythological concepts. The article concludes with a detailed discussion of her image and role within the wider cosmological context of Han grave art.

  4. [The professionalized transformation of medical witchcraft in the Qin-Han Dynasties].

    Science.gov (United States)

    Liu, Yang; Liu, Changhua

    2014-03-01

    By witchcraft, it refers to the activities of imagining and intending to affect or control the object through"supernatural power". Ancient witchcraft was applied extensively in which those applied for medical purpose included sorcery, praying, superstitious art of anti-disaster, and tabooing, were collectively called"medical witchcraft". During the Qin-Han periods, witchcraft was transformed by the theory of Yin-Yang and Five-Phases as a part of technical profession. Among them, the system of demon-ghost witchcraft was replaced by the necromantic ghost system; exorcism and taboo system were infiltrated with the conception of the art of mathematics and technical system; whereas the superstitious art of anti-disaster was replaced by incantation. The remnants of medical witchcraft not yet totally transformed were also applied by the technical professionals of the Qin-Han Dynasties.

  5. Bong-Han Corpuscles as Possible Stem Cell Niches on the Organ-Surfaces

    Directory of Open Access Journals (Sweden)

    Min Su Kim

    2008-03-01

    Full Text Available Objectives : Showing that Bong-Han corpuscles(BHC are suppliers of the stem cells in adulthood, and the Bong-Han ducts(BHD are transportation routes of stem cells. Methods : BHC and BHD were obtained from the internal organ-surfaces of rats. The sliced BHC and BHD were immunostained with various stem cell markers. Extracellular matrices were also analyzed by immunohistochemistry. Result : The presence of mesenchymal stem cells was confirmed by the expression of Integrin beta 1, Collagen type 1 and Fibronectin. But CD54 was not expressed. The hematopoietic stem cell marker, Thy 1 was strongly expressed. BHDs showed Collagen type 1, Fibronectin, and vWF expression. Conclusion : Both hematopoietic and mesenchymal stem cell markers were expressed strongly in BHC similarly as in bone marrow. An endothelial cell marker(vWF demonstrated the possibility of the stem cell transportation routes of BHD.

  6. Y-chromosome haplotype distribution in Han Chinese populations and modern human origin in East Asians

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    We investigated the distribution of Y-chromosome haplotype using 19 Y-SNPs in Han Chinese populations from 22 provinces of China. Our data indicate distinctive patterns of Y chromosome between southern and northern Han Chinese populations. The southern populations are much more polymorphic than northern populations. The latter has only a subset of the southern haplotypes. This result confirms the genetic difference observed between southern and northern ethnic populations in East Asia. It supports the hypothesis that the first settlement of modern hu-mans of African origin occurred in the southern part of East Asia during the last Ice Age, and a northward migration led to the peopling of northern China.

  7. Parity and litter size effects on maternal behavior of Small Tail Han sheep in China.

    Science.gov (United States)

    Lv, Shen-Jin; Yang, Yan; Li, Fu-Kuan

    2016-03-01

    The effects of parity and litter size on maternal behavior of Small Tail Han sheep was investigated at Linyi University, China. Sixty-eight ewes were observed from parturition to weaning. Continuous focal animal sampling was used to quantify the duration of maternal behaviors. Ewe feces were collected every 2 days and estradiol concentration was measured with an enzyme immunoassay kit. All lambs were weighed 24 h after parturition and again at 35 days of age. Parity increased sucking, following, grooming, low-pitched bleat, head-up and udder-refusal behavior and decreased aggressive behavior (P primiparous ewes at birth (P primiparous ewes. Parity and litter size may have effects on maternal behavior during lactation. Ewes that have 2-3 lambs may be more suitable for production of Small Tail Han sheep in China.

  8. Debating Modernity as Secular Religion: Hans Kelsen’s futile exchange with Eric Voegelin

    DEFF Research Database (Denmark)

    Thomassen, Bjørn

    2014-01-01

    This article reviews the mysterious and recently published last book by Hans Kelsen, “Secular Religion. A Polemic Against the Misinterpretation of Modern Social Philosophy, Science and Politics as ‘New Religions’”, contextualizing it with reference to the little known dialogue between Hans Kelsen...... and Eric Voegelin. The confrontation between Kelsen and Voegelin, two of the most illustrious émigré scholars who found in America their new home, is important to revisit because it touches upon several axes of debate of crucial importance to postwar intellectual history: the religion/secularity debate......, the positivist/anti-positivist debates, and the controversy that also led to the famous Voegelin/Arendt debate: how to read the horrors of totalitarianism into a historical trajectory of modernity. Although the Kelsen/Voegelin exchange ended in failure and bitterness its substance matter goes to the heart...

  9. Inverted migration of rare whisker sheatfish in Nong-Han Lake, northeastern Thailand: implications for conservation.

    Science.gov (United States)

    Phongkaew, P; Arunyawat, U; Swatdipong, A; Hongtrakul, V

    2014-09-12

    Nong-Han Lake, Thailand, sustains the whisker sheatfish (Micronema bleekeri Günther, 1864), which is a rare species of freshwater catfish. Wild-caught whisker sheatfish has been intensively harvested to meet market demand; yet, genetic information about this species remains unknown. To assist with the in situ conservation of whisker sheatfish populations in Nong-Han Lake, 35 and 34 individuals from the middle (MN) and lower (LN) areas of the lake, respectively, were studied using 7 microsatellite loci. Low genetic variation was detected in the MN (HO=0.338, AR=2.710) and LN (HO=0.394, AR=2.714) populations. Genetic differentiation between the 2 populations was significant (FST=0.063, PChao Phraya River basins is required to assist national-scale conservation efforts.

  10. Association of Gghrelin Polymorphisms with Metabolic Syndrome in Han Nationality Chinese

    Institute of Scientific and Technical Information of China (English)

    LING-LING XU; HONG-DING XIANG; CHANG-CHUN QIU; QUN XU

    2008-01-01

    Objective To investigate the association of ghrelin gene polymorphisms with metabolic syndrome in Han Nationality Chinese. Methods A total of 240 patients with metabolic syndrome annd 427 adults aged above forty years were recruited. Genotypes were determined by polymerase chain reaction and restriction fragment lengthpolymorphism analysis.Results The allelic frequency of the Leu72Met polymorphismwas 17.3% in the patient group and 11.9% in the control group(x2=7.36, P=0.007). Metabolic syndrome was more prevalent among carriers of the Met72 variant (43.8 vs 33.1%, age- and sex-adjusted odds ratio=1.57, P=0.01). No Arg51Gln variants were found in our study subjects. Conclusion Rather than being associated with its individual components, Leu72Met polymorphism is associated with metabolic syndrome in the Han Nationality Chinese. Arg51Gln polymorphism is rare in the Hart Nationality Chinese.

  11. Genetic Analysis of 15 STR Loci in Chinese Han Population from West China

    Institute of Scientific and Technical Information of China (English)

    Ya-Jun Deng; Jiang-Wei Yan; Xiao-Guang Yu; Yuan-Zhe Li; Hao-Fang Mu; Yan-Qing Huang; Xiao-Tie Shi; Wei-Min Sun

    2007-01-01

    Allele frequencies for 15 short tandem repeat (STR) loci (D8S1179, D21S11, D7S820, CSF1PO, D3S1358, TH01, D13S317, D16S539, D2S1338, D19S433, vWA, TPOX, D18S51, D5S818, and FGA) were obtained from 7,636 unrelated individuals of Chinese Han population living in Qinghai and Chongqing, China. Totally 206 alleles were observed, with the corresponding allele frequencies ranging from 0.0001-0.4982. Chi-square test showed that all of the STR loci agreed with the Hardy-Weinberg equilibrium. We also compared our data with previously published population data of other ethnics or areas. The results are valuable for human identification and paternity testing in Chinese Han population.

  12. Angiogenin gene polymorphism: A risk factor for diabetic peripheral neuropathy in the northern Chinese Han population.

    Science.gov (United States)

    Wang, Hongli; Fan, Dongsheng; Zhang, Yingshuang

    2013-12-25

    Angiogenin is associated with the pathogenesis of diabetic peripheral neuropathy. Here, we quenced the coding region of the angiogenin gene in genomic DNA from 207 patients with type 2 diabetes mellitus (129 diabetic peripheral neuropathy patients and 78 diabetic non-neuropathy patients) and 268 healthy controls. All subjects were from the Han population of northern China. No mutations were found. We then compared the genotype and allele frequencies of the angiogenin synonymous single nucleotide polymorphism rs11701 between the diabetic peripheral neuropathy patients and controls, and between the diabetic neuropathy and non-neuropathy patients, using a case-control design. We detected no statistically significant genetic associations. Angiogenin may not be associated with genetic susceptibility to diabetic peripheral neuropathy in the Han population of northern China.

  13. Hans-Peter Schultze, a great paleoichthyologist for whom work is synonymous with enjoyment

    Directory of Open Access Journals (Sweden)

    R. Cloutier

    2002-01-01

    Full Text Available In the summer of 1982, Hans-Peter Schultze and Gloria Arratia were invited to a small museum located on a fossiliferous site of the Devonian Escuminac Formation in Miguasha, Quebec, eastern Canada, Hans-Peter was to work with Marius Arsenault, the director of the Miguasha Museum, on the skull of the elpistostegalid Elpistostege watsoni, a species closely related to basal tetrapod. In addition, he went through the collections to describe and measure numerous juvenile specimens of the osteolepiform. Eusthenopteran foordi. As expected, there two projects turned out to be important contributions in lower vertebrate paleontology and systematics: one on the origin of tetrapods (1985, and the second one on growth patterns of a Late Devonian fish (1984. During his visit to Miguasha, Hans-Peter also spent time digging for fossils and drawing numerous specimens in the collection. In addition, in order to help the personnel of the museum to identify some of the Escuminac fished, he created an identification key based on the gross morphology of the scales. For a small group of undergraduate students, hired at the museum during the summer as naturalists, it was a unique opportunity to discuss paleontology with a leading researcher. We were amazed by his willingness to talk to us, even if then most of us only spoke French! For the first time, we were exposed to Hennigian methodology and its usage in vertebrate paleontology during and evening lecture that Hans-Peter prepared for us. His lecture was delightful; it was an intensive course in lower vertebrate anatomy, and an intellectual journey among the philosophers Karl Marx and Karl Popper, the entomologists Willy Hennig and Lars Brundin, and "The Band of Four" (Rosen et al., 1981. It was for most of us our first exposure to science, as it should be done. We were all impressed by his knowledge and above all by his simplicity and friendliness. Two years later I started my Ph.D. at The University of Kansas

  14. More heritability probably captured by psoriasis genome-wide association study in Han Chinese.

    Science.gov (United States)

    Jiang, Long; Liu, Lu; Cheng, Yuyan; Lin, Yan; Shen, Changbing; Zhu, Caihong; Yang, Sen; Yin, Xianyong; Zhang, Xuejun

    2015-11-15

    Missing heritability is a common problem in genome-wide association studies in complex diseases/traits. To quantify the unbiased heritability estimate, we applied the phenotype correlation-genotype correlation regression in psoriasis genome-wide association data in Han Chinese which comprises 1139 cases and 1132 controls. We estimated that 45.7% heritability of psoriasis in Han Chinese were captured by common variants (s.e.=12.5%), which reinforced that the majority of psoriasis heritability can be covered by common variants in genome-wide association data (68.2%). The results provided evidence that the heritability covered by psoriasis genome-wide genotyping data was probably underestimated in previous restricted maximum likelihood method. Our study highlights the broad role of common variants in the etiology of psoriasis and sheds light on the possibility to identify more common variants of small effect by increasing the sample size in psoriasis genome-wide association studies.

  15. The first Koç Han: Pioneering modern architecture in Ankara

    Directory of Open Access Journals (Sweden)

    Oya Atalay Franck

    2013-01-01

    Full Text Available Koç Holding is the most established conglomerate in Turkey. Th e company’s beginnings date from the mid 1920s, when Ahmet Vehbi Koç, founder of Koç Holding, had his first own company registered with the Ankara Chamber of Commerce. In 1932, Koç moved his business from his father’s store on Anafartalar Street to a new building, the first Koç Han, erected the same year on Çankırı Street Nr.13 in Ulus. Th e building’s designer was Swiss-Austrian architect Ernst Arnold Egli, who had come to Turkey only five years earlier upon invitation by the government to work as chief architect of the Ministry of National Education. During his stay, which lasted from 1927 until 1940, Egli realized about 40 projects and worked on many more. Koç Han is the rare example of a commercial building by Egli. At a time when the urban aspect of the old town center of Ankara consisted mostly of one-or two-storeyed stone-and-wood houses, the first Koç Han represented an altogether new building type for the town, in being a multipurpose edifice with space for shops at street level, with large storage facilities below ground, and providing off ices and housing on the upper fl oors. Th e functional rigor of the plan and the sober modernism of the building’s facades contrasted strongly with the architecture of the time. In this respect, the first Koç Han was a strong statement regarding Ahmet Vehbi Koç’s belief in a modern Turkey and to the contribution of the building’s architect, Ernst Arnold Egli, to this project.

  16. Sintoma e invenção no caso Pequeno Hans de Freud.

    Directory of Open Access Journals (Sweden)

    Paulo Eduardo Viana Vidal

    2015-07-01

    Full Text Available As we will try to show in the article, initial result of a research on the symptom in Freud and Lacan, Freud's case study of Little Hans, published over one hundred years ago, teaches us how a subject whose world collapsed and who is taken by anguish, can invent, rig up with the remaining fragments a symptom that reorganizes for himself a liveable world.

  17. Play / play under the beyond the pleasure principle (1920 Hans and little (1909

    Directory of Open Access Journals (Sweden)

    Jeferson José Moebus Retondar

    2015-11-01

    Full Text Available The purpose of the test is to point out the place of the game / joke within the context of Freudian psychoanalytic theory from the texts of Beyond the Pleasure and Little Hans principle as metaphors for thinking about the game / play and possible teacher intervention of the repercussions of physical education in kindergarten to consider the psychoanalysis of appropriation so the playful manifestation.

  18. Hans Sperber e Freud: a origem sexual da linguagem humana e a psicanálise

    Directory of Open Access Journals (Sweden)

    Maria Antonieta Amarante de Mendonça Coh

    2014-03-01

    Full Text Available Neste trabalho, discute-se a relação entre a psicanálise, a linguageme sua origem sexual, tendo por base dois autores: Hans Sperber(1912, cuja proposta é a de que a linguagem humana falada temuma origem e um desenvolvimento vinculados ao sexual; SigmundFreud, nos textos em que trata de questões relativas à linguagemem sentido estrito.

  19. Association study confirmed susceptibility loci with keloid in the Chinese Han population.

    Directory of Open Access Journals (Sweden)

    Fei Zhu

    Full Text Available Keloid is benign fibroproliferative dermal tumors with unknown etiology. Recently, a genome-wide association study (GWAS in Japanese population has identified 3 susceptibility loci (rs873549 at 1q41, rs940187 and rs1511412 at 3q22.3, rs8032158 at 15p21.3 for keloid. In order to examine whether these susceptibility loci are associated with keloid in the Chinese Han population, twelve previously reported SNPs were selected for replication in 714 cases and 2,944 controls by using Sequenom MassArray system. We found three SNPs in two regions showed significant association with keloid in the Chinese Han population: 1q41 (rs873549, P = 3.03×10(-33, OR = 2.05, 95% CI: 1.82-2.31 and rs1442440, P = 9.85×10(-18, OR = 0.56, 95% CI: 0.49-0.64, respectively and 15q21.3 (rs2271289 located in NEDD4, P = 1.02×10(-11, OR = 0.66, 95% CI: 0.58-0.74. We also detected one risk haplotype AG (P = 1.36×10(-31, OR = 2.02 and two protective haplotypes of GA and AA (GA, P = 1.94×10(-19, OR = 0.53, AA, P = 0.00043, OR = 0.78, respectively from the two SNPs (rs873549 and rs1442440. Our study confirmed two previously reported loci 1q41 and 15q21.3 for keloid in the Chinese Han population, which suggested the common genetic factor predisposing to the development of keloid shared by the Chinese Han and Japanese populations.

  20. 50 aastat Euroopa integratsiooni: aeg uueks alguseks / Hans-Gert Pöttering

    Index Scriptorium Estoniae

    Pöttering, Hans-Gert, 1945-

    2007-01-01

    Ilmunud ka: Virumaa Teataja, 23. märts 2007, lk. 1; Pärnu Postimees, 24. märts 2007, lk. 19; Koit, 24. märts 2007, lk. 6; Põhjarannik, 24. märts 2007, lk. 2; Severnoje Poberezhje, 24. märts 2007, lk. 2. Euroopa Parlamendi presidendi Hans-Gert Pötteringi mõtted Euroopa Ühenduse asutamislepingu sõlmimise 50. aastapäeva puhul

  1. La Torre de Hanói y los Qn Grafos

    Directory of Open Access Journals (Sweden)

    Mª Milagros Latasa Asso

    2011-10-01

    Full Text Available La Torre de Hanói es uno de los hallazgos matemáticos más ingeniosos de la matemática recreativa. Gracias a una leyenda con tinte oriental hoy se conoce de modo universal. Se describen en este artículo las relaciones entre las soluciones del rompecabezas y los ciclos hamiltonianos en los grafos Qn.

  2. Genetic variants associated with lean and obese type 2 diabetes in a Han Chinese population

    Science.gov (United States)

    Kong, Xiaomu; Xing, Xiaoyan; Hong, Jing; Zhang, Xuelian; Yang, Wenying

    2016-01-01

    Abstract Type 2 diabetes (T2D) is highly phenotypically heterogeneous. Genetics of the heterogeneity of lean and obese T2D is not clear. The aim of the present study was to identify the associations of T2D-related genetic variants with the risks for lean and obese T2D among the Chinese Han population. A case–control study consisting of 5338 T2D patients and 4663 normal glycemic controls of Chinese Han recruited in the Chinese National Diabetes and Metabolic Disorders Study was conducted. T2D cases were identified according to the 1999 World Health Organization criteria. Lean T2D was defined as T2D patient with a body mass index (BMI) CAMK1D, HHEX, and TCF2 were associated with the risk for lean T2D, and SNPs in or near KCNQ1 and FTO were associated with the risk for obese T2D. The results showed that the GRS for 25 T2D-related SNPs was more strongly associated with the risk for lean T2D (Ptrend = 2.66 × 10−12) than for obese T2D (Ptrend = 2.91 × 10−5) in our study population. Notably, the T2D GRS contributed to lower obesity-related measurements and greater β-cell dysfunction, including lower insulin levels in oral glucose tolerance test, decreased insulinogenic index, and Homeostasis Model Assessment for β-cell Function. In conclusion, our findings identified T2D-related genetic loci that contribute to the risk of lean and obese T2D individually and additively in a Chinese Han population. Moreover, the study highlights the contribution of known T2D genomic loci to the heterogeneity of lean and obese T2D in Chinese Hans. PMID:27281091

  3. Hans Bethe and Physics in/of the 20th Century

    Energy Technology Data Exchange (ETDEWEB)

    Schweber, Silvan [Brandeis University

    2012-12-12

    I will present some facets of Hans Bethe’s life to illustrate how I have used biography to narrate certain aspects of the history of twentieth century physics. I will focus on post World War II quantum field theory, on the relation between solid state/condensed matter physics and high energy physics, and make some observations regarding certain “top down” views in solid state physics in postmodernity.

  4. Zur Frage der Gewalt in Hubert Fichtes Interviews mit Hans Eppendorfen

    Directory of Open Access Journals (Sweden)

    Manfred Weinberg

    2000-11-01

    Full Text Available Este ensaio investiga a importância da violência na entrevista de Hubert Fichte com Hans Eppendorfer, o Homem de Couro - no plano conteudístico e no plano estrutural. Tenta-se demonstrar como Fichte manipula (violentamente o entrevistado. A violência que é tema da entrevista é examinada dentro do horizonte da teoria fichtiana do ritual.

  5. Hermeneutics and Dialectics: (Hegel, Husserl, Heidegger and) Hans-Georg Gadamer

    OpenAIRE

    Khan, Haider

    2008-01-01

    The purpose of this paper is to explore briefly the role that a more phenomenological conception of dialectical development of consciousness plays in Hans-Georg Gadamer's work on hermeneutics. This is done with both an implicit understanding of the dialectical development of consciousness and self-consciousness in Gadamer and some explicit references to Hegel’s Phenomenology of Spirit and his Science of Logic in connection with Gadamer's work. However, the twentieth century departures from H...

  6. The Stable of Central Authorities in Han Dynasty%汉代中央的厩

    Institute of Scientific and Technical Information of China (English)

    沈刚

    2015-01-01

    The Stable of central authorities in Han dynasty was set up inside and outside Changan city. The amount of the stables of central authorities in the latter Han was lower than those in the Former Han.The stable of central authorities was administered by the system of emperor finance. The horses of the stable were chosen from the traditional herse breeding area.Confiscation and requisition from the local government were al⁃so the main sources. The horses were provided for emperor and his families to ride, sacrifices, complement to the regional post house, and as army horse. The officers of the stable were including of ling(令), cheng(丞),and jian(监). They were close to emperor in spite of their humble status. The change of stable in Han dynasty reflect⁃ed the development of the administrative system.%汉代中央的厩设置于长安城内外。东汉中央厩的数目较之西汉有所减省。中央厩由帝室财政系统掌管,其马匹主要从传统养马区选择,罚没、从地方征调也是中央厩马的重要来源。厩马主要供皇帝及帝室成员骑乘,祭祀、补充地方传置,以及作为军马等。中央厩所设置的职官主要有令、丞、监等,其秩级虽低,但和皇帝关系密切。厩在两汉时期的变化从一个侧面反映了汉代行政体系逐渐发育成熟。

  7. Polymorphism analysis of 15 STR loci in a large sample of Guangdong (Southern China) Han population.

    Science.gov (United States)

    Chen, Ling; Lu, Huijie; Qiu, Pingming; Yang, Xingyi; Liu, Chao

    2015-11-01

    AmpFℓSTR Sinofiler PCR Amplification Kit is specially developed for Chinese forensic laboratories, but there are little population-genetic data about this kit for Southern China. This kit contains 15 STR loci: D8S1179, D21S11, D7S820, CSF1PO, D3S1358, D13S317, D16S539, D2S1338, D19S433, vWA, D18S51, D6S1043, D12S391, D5S818 and FGA. We have conducted genotyping experiments on the 15 STR loci in 5234 unrelated individuals from Guangdong (Southern China). We observed a total of 243 alleles in the group with the allelic frequency values ranging from less than 0.0001 to 0.3686. Our statistic analysis indicates that the 15 STR loci conform to the Hardy-Weinberg's equilibrium (p>0.05). The highest polymorphism was found at D6S1043 locus and the lowest was found at D3S1358. The combined power of discrimination reached 0.99999999999999999977431 and the combined probability of paternity exclusion reached 0.999999721 for 15 STR loci. Guangdong Han population had significant differences compared with Shaanxi, Shandong and Henan province of Northern China. A Neighbor-joining tree indicates that the Guangdong Han has a close genetic relationship with the Yunnan population. Significant differences were found between Guangdong Han population and other reported populations (Japanese, Philippine, African American, Caucasian, Hispanic and Western Romanian) at 2-11 STR loci. The results may provide useful information for forensic sciences and population genetics studies. The present findings indicate that all the 15 STR loci are highly genetically polymorphic in the Han population of Guangdong.

  8. CPPCC Vice Chairman and CPAPD President Mr.Han Qide Visits Mexico and Argentina via France

    Institute of Scientific and Technical Information of China (English)

    2014-01-01

    <正>At the invitation of the Mexican Council on Foreign Relations(COMEXI)and the World Peace Council(WPC),Mr.Han Qide,Vice Chairman of the Chinese People’s Political Consultative Conference(CPPCC)and President of the Chinese People’s Association for Peace and Disarmament(CPAPD)attended the WPC international conference,visited Mexico and Argentina,and transited through

  9. A comprehensive analysis of NDST3 for schizophrenia and bipolar disorder in Han Chinese.

    Science.gov (United States)

    Zhang, C; Lu, W; Wang, Z; Ni, J; Zhang, J; Tang, W; Fang, Y

    2016-01-05

    A novel susceptibility locus (rs11098403) for schizophrenia and bipolar disorder (BD) was identified in an Ashkenazi Jewish population by a recent large-scale genome-wide association study. The rs11098403 is located in the vicinity of the gene encoding N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3, (NDST3). This study aimed to replicate the results in a Han Chinese population and then potentially extend these findings. We performed a two-stage study to investigate the association of NDST3 with the schizophrenia and BD risk in the Han Chinese. In stage 1, a total of 632 patients with schizophrenia, 654 patients with BD and 684 healthy controls were recruited from the Shanghai region. In stage 2, 522 schizophrenia patients and 547 normal subjects were enrolled from the Hangzhou region. Then, we conducted a meta-analysis based on the present literature. In stage 1, the single nucleotide polymorphism (SNP) rs11098403 showed a significant association with schizophrenia (corrected P=0.005). The frequency of the rs11098403 G allele was significantly lower among schizophrenia patients than among the controls (odds ratio (OR)=0.68, 95% confidence interval (CI): 0.55-0.84, corrected P=0.002). No significant difference was observed in individual SNP marker genotypes or allele distributions between the BD and control groups. In stage 2, the association of rs11098403 with schizophrenia could be validated (genotypic P=0.001 and allelic P=0.0003). After pooling all data from 1861 patients with schizophrenia and 2081 controls, we observed a significant association of the rs11098403 G allele with schizophrenia (Z=5.56, Pschizophrenia in the Han Chinese. Further investigations are warranted to identify the precise mechanism regulating brain NDST3 expression in the Han Chinese. These results would help to explain the pathophysiological mechanism of schizophrenia.

  10. Comparative transcriptome profiling of longissimus muscle tissues from Qianhua Mutton Merino and Small Tail Han sheep

    OpenAIRE

    Limin Sun; Man Bai; Lujie Xiang; Guishan Zhang; Wei Ma; Huaizhi Jiang

    2016-01-01

    The Qianhua Mutton Merino (QHMM) is a new sheep (Ovis aries) variety with better meat performance compared with the traditional local variety Small Tail Han (STH) sheep. We aimed to evaluate the transcriptome regulators associated with muscle growth and development between the QHMM and STH. We used RNA-Seq to obtain the transcriptome profiles of the longissimus muscle from the QHMM and STH. The results showed that 960 genes were differentially expressed (405 were up-regulated and 555 were dow...

  11. Lakatos und Bohrs Programm. Entgegnung auf eine Kritik von Hans Radder

    OpenAIRE

    Carrier, Martin

    1983-01-01

    In a paper published in this Journal, Hans Radder argues that a detailed analysis of the degenerating phase of Bohr's programme reveals the basic incorrectness of Lakatos' own reconstruction of this period. Furthermore the corrected version shows the impossibility to account for the development in Lakatosian concepts. In this reply I try to point out that a slight modification of Lakatos' reconstruction is sufficient for reconciling the theory with the historical data. It is not Lakatos's the...

  12. Association study of SHANK3 gene polymorphisms with autism in Chinese Han population

    Directory of Open Access Journals (Sweden)

    Ruan Yan

    2009-06-01

    Full Text Available Abstract Background Autism, a heterogeneous disease, is described as a genetic psychiatry disorder. Recently, abnormalities at the synapse are supposed to be important for the etiology of autism.SHANK3 (SH3 and multiple ankyrin repeat domains protein gene encodes a master synaptic scaffolding protein at postsynaptic density (PSD of excitatory synapse. Rare mutations and copy number variation (CNV evidence suggested SHANK3 as a strong candidate gene for the pathogenesis of autism. Methods We performed an association study between SHANK3 gene polymorphisms and autism in Chinese Han population. We analyzed the association between five single nucleotide polymorphisms (SNPs of the SHANK3 gene and autism in 305 Chinese Han trios, using the family based association test (FBAT. Linkage disequilibrium (LD analysis showed the presence of LD between pairwise markers across the locus. We also performed mutation screening for the rare de novo mutations reported previously. Results No significant evidence between any SNPs of SHANK3 and autism was observed. We did not detect any mutations described previously in our cohort. Conclusion We suggest that SHANK3 might not represent a major susceptibility gene for autism in Chinese Han population.

  13. Association between Common Genetic Variants and Polycystic Ovary Syndrome Risk in a Chinese Han Population

    Science.gov (United States)

    Sun, Ying; Yuan, Yi; Yang, Hua; Li, Jingjie; Feng, Tian; Ouyang, Yongri; Jin, Tianbo; Liu, Ming

    2016-01-01

    Objective: Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies affecting 5-7% of reproductive age women worldwide. The aim of our study was to explore the PCOS-related single nucleotide polymorphism (SNP) associations between common genetic variants and PCOS risk in a Han Chinese women population. Methods: In this case-control study, 285 Chinese Han women aged 28.50±6.858 years with PCOS and 299 controls of a mean age of 32.66±7.018 years were compared. We selected recently published genome-wide association studies (GWAS) which identified several genetic loci in PCOS. All the SNPs were genotyped by Sequenom Mass-ARRAY technology. Associations between the gene and the risk of PCOS were tested using various genetic models by Statistical Package for the Social Sciences and Plink. Results: We found that rs705702 in the RAB5B/SUOX was associated with PCOS (odds ratio=1.42; 95% confidence interval=1.08-1.87, p=0.011) and increased the PCOS risk. The genotypic model analysis also showed that rs705702 was associated with PCOS risk. Conclusion: Our results suggest that SNPs rs705702 in gene RAB5B/SUOX was associated with PCOS in Han Chinese women. PMID:27217259

  14. The chronological age estimation of third molar mineralization of Han population in southwestern China.

    Science.gov (United States)

    Qing, Maofeng; Qiu, Lihua; Gao, Zhi; Bhandari, Kishor

    2014-05-01

    The purpose of the study was to estimate the chronology of third molar mineralization in Han population of southwestern China and find its unique characteristics so that it would provide a reference in several legal cases like forensic age estimation. The study used Demirjian's staging method to study 2192 orthopantomograms of 984 male and 1208 female subjects aged between 8 and 25 years. The statistical data was analyzed by Student's t test and ANOVA. The conclusions of the study are: (1) The chronological mineralization age of third molars of Han population in Southwestern China is similar to the Turkish and the Japanese, was earlier than the Austrian and Han of South China, but later than the Spanish. (2) The mineralization timing of the third molars between two sides in maxilla or mandible has no significant differences in the same gender group. (3) There is no significant difference in mineralization of third molars between male and female, except for tooth 48 in Demirjian's stage E. (4) The mineralization of third molar in maxilla is earlier than mandible.

  15. Runoff and Sediment Response to Cascade Hydropower Exploitation in the Middle and Lower Han River, China

    Directory of Open Access Journals (Sweden)

    Junhong Zhang

    2017-01-01

    Full Text Available With the rapid development of hydropower exploitation in China, changes in runoff and sediment transport have become a significant issue that cannot be neglected. In this study, the Han River was selected as a study case, where the runoff variation and changes in sediment load at the Baihe, Huangjiagang, Huangzhuang, and Xiantao stations were analyzed in different time periods. The results indicate that impact of cascade hydropower exploitation on runoff and sediment transport is significantly different even during the same time periods. After reservoir regulation, the decreasing of sediment load is faster than that of runoff. Strong positive correlation between runoff and sediment load exists during different time periods, while reservoir operation leads to different turning points at the Baihe, Huangjiagang, Huangzhuang, and Xiantao stations in the middle and lower Han River. As a key driving factor, runoff variation contributed to sediment transport with different impact index CR. The impact index CR before and after the first change point at the Baihe, Huangjiagang, Huangzhuang, and Xiantao stations is 43.35%, −3.68%, 11.17%, and 30.12%, respectively. This study helps us understand and evaluate the hydrological changes under cascade hydropower exploitation in the middle and lower Han River.

  16. Association of the CTLA4 gene with Graves' disease in the Chinese Han population.

    Directory of Open Access Journals (Sweden)

    Shuang-Xia Zhao

    Full Text Available To determine whether genetic heterogeneity exists in patients with Graves' disease (GD, the cytotoxic T-lymphocyte associated 4 (CTLA-4 gene, which is implicated a susceptibility gene for GD by considerable genetic and immunological evidence, was used for association analysis in a Chinese Han cohort recruited from various geographic regions. Our association study for the SNPs in the CTLA4 gene in 2640 GD patients and 2204 control subjects confirmed that CTLA4 is the susceptibility gene for GD in the Chinese Han population. Moreover, the logistic regression analysis in the combined Chinese Han cohort revealed that SNP rs231779 (allele frequencies p = 2.81x10(-9, OR = 1.35, and genotype distributions p = 2.75x10(-9, OR = 1.42 is likely the susceptibility variant for GD. Interestingly, the logistic regression analysis revealed that SNP rs35219727 may be the susceptibility variant to GD in the Shandong population; however, SNP, rs231779 in the CTLA4 gene probably independently confers GD susceptibility in the Xuzhou and southern China populations. These data suggest that the susceptibility variants of the CTLA4 gene varied between the different geographic populations with GD.

  17. Hans von Bülow: creativity and neurological disease in a famous pianist and conductor.

    Science.gov (United States)

    Wöhrle, Johannes C; Haas, Frithjof

    2007-01-01

    Hans von Bülow (1830-1894) was a conductor and pianist of worldwide reputation and founder of many stylistic interpretations of classic and romantic symphonies. The close friendship with Richard Wagner, but not the enthusiastic admiration of his dramatic musical opus, ended abruptly when Hans von Bülow became aware of the betrayal of his wife Cosima and Richard Wagner. Hans von Bülow reported symptoms and signs of neurological disease in many letters that were kept and edited by his second wife Marie. For decades he suffered from chronic neuralgiforme headaches, which were caused by a tumor of the cervical radicular nerves. At the age of 45 years, he suddenly developed a motorsensory deficit in the right arm and hand and a contralateral facial deficit, suggestive of brainstem infarction. He recovered and celebrated even greater successes as a musician, although phases of major depression also interfered with his professional life. In the last, phase of his life, he experienced the consequences of generalized atherosclerosis and cerebral microangiopathy. It was a second cerebrovascular accident of the brainstem that caused his death, only 10 months after his last concert performance. Although his death occurred in Egypt, an autopsy was performed by Professor Ludwig Edinger and the results will be presented.

  18. [The prevalence, prevention and treatment of cattle epidemic during the Han-Tang Period].

    Science.gov (United States)

    Han, Yi

    2013-03-01

    About 21 times of cattle epidemic with rather strong infectivity happened during the Han-Tang Period, including 6 in the Eastern Han Dynasty, 2 in the Jin Dynasty, 4 in the Southern and Northern Dynasties, 8 in the Tang Dynasty and 1in the Five Dynasty. Most of them were spread along the Yellow River and the northern region of the Huai River. The type of cattle epidemic included the acute cattle plague, cattle bovine mange, cattle yellow fever and cattle rotten hoof disease, etc. Its occurrence and prevalence brought a serious influentce on the society of the Han and Tang Dynasties, causing massive mortality of farm cattle, and then the shortage of animal power, and threatening the agriculture, which drew the attention of the governments, physicians, agriculturists, astrologists and Taoists. The medical measures and economic measures were adopted for the prevention and treatment of cattle epidemic. Especially, prescriptions in the books of medicine and agriculture exerted positive effects on the containment of cattle epidemic. On the other hand, its prevalence and the mass mortality of farm cattle, in a way, promoted, to certain extent, the improvement of the government's function of relief, the updating of the methods of agriculture and the creation of new farm tools, and being regarded as a main cause for the technological innovation of agriculture.

  19. Genetic Variation of 25 Y-Chromosomal and 15 Autosomal STR Loci in the Han Chinese Population of Liaoning Province, Northeast China.

    Science.gov (United States)

    Yao, Jun; Wang, Bao-Jie

    2016-01-01

    In the present study, we investigated the genetic characteristics of 25 Y-chromosomal and 15 autosomal short tandem repeat (STR) loci in 305 unrelated Han Chinese male individuals from Liaoning Province using AmpFISTR® Yfiler® Plus and IdentifilerTM PCR amplification kits. Population comparison was performed between Liaoning Han population and different ethnic groups to better understand the genetic background of the Liaoning Han population. For Y-STR loci, the overall haplotype diversity was 0.9997 and the discrimination capacity was 0.9607. Gene diversity values ranged from 0.4525 (DYS391) to 0.9617 (DYS385). Rst and two multi-dimensional scaling plots showed that minor differences were observed when the Liaoning Han population was compared to the Jilin Han Chinese, Beijing Han Chinese, Liaoning Manchu, Liaoning Mongolian, Liaoning Xibe, Shandong Han Chinese, Jiangsu Han Chinese, Anhui Han Chinese, Guizhou Han Chinese and Liaoning Hui populations; by contrast, major differences were observed when the Shanxi Han Chinese, Yunnan Bai, Jiangxi Han Chinese, Guangdong Han Chinese, Liaoning Korean, Hunan Tujia, Guangxi Zhuang, Gansu Tibetan, Xishuangbanna Dai, South Korean, Japanese and Hunan Miao populations. For autosomal STR loci, DP ranged from 0.9621 (D2S1338) to 0.8177 (TPOX), with PE distributing from 0.7521 (D18S51) to 0.2988 (TH01). A population comparison was performed and no statistically significant differences were detected at any STR loci between Liaoning Han, China Dong, and Shaanxi Han populations. The results showed that the 25 Y-STR and 15 autosomal STR loci in the Liaoning Han population were valuable for forensic applications and human genetics, and Liaoning Han was an independent endogenous ethnicity with a unique subpopulation structure.

  20. [Mode and size of HPA-typed platelet apheresis donor bank in Chinese Han population].

    Science.gov (United States)

    Dai, Yu-Dong

    2010-08-01

    This study was purposed to determine the mode and size of human platelet antigens (HPA) typed platelet apheresis donor bank. The published data of HPA distribution collected from Chinese Han population of 16 provinces were analyzed. The combined data were tested with the Hardy-Weinberg equilibrium. The results showed that the bb homozygote was not detected in HPA-1, -4, -6, -10, and b gene was not found in HPA-7-9, 11-14, -16. There were 648 combined HPA 1-16 genotypes in Chinese Han population, and the cumulative frequency of 42 combinations higher than 0.001 were 0.9763. The highest frequency (0.2012) in combination was HPA-(7-8-9-11-12-13-14-16) aa - (1-4-5-6-10) aa-2aa-3ab-15ab. The probability of HPA dual antigen mismatch in HPA-15, -3 and -2 was higher than the 0.1, and the probability in the HPA-1, -5, and -6 was between 0.01 - 0.1. The probability of full-match in HPA1-16 antigens was 0.3195 in Chinese Han population after the random blood transfusion. According to the curve drawn by donor number (N) versus frequency (F), the regression equation LogN = -0.4394 x Ln (F) +0.4324 was derived at P = 95%. If the derived frequency (product of HPA frequency and ABO frequency) is 0.005, then the N should be 576.07 at least in Chinese Han population. It is concluded that the mode of regional, multi-center database of HPA-typed platelet apheresis donor bank may be acceptable in Chinese Han population, and the suitable number of HPA-typed platelet donor in one bank may be 600. Therefore, the bank can be used to treat the platelet transfusion refractoriness (PTR) caused by HPA-15, 3 and 2 mismatch mainly, and can be expanded effectively in similar genetic background to deal with the low-frequency HPA antigens mismatch. The number of HPA-typed platelet apheresis donor influences not only on the frequency of HPA, but also on the frequency of ABO group.

  1. Chronological age estimation of third molar mineralization of Han in southern China.

    Science.gov (United States)

    Zeng, Dong Lin; Wu, Zhi Ling; Cui, Min Yi

    2010-03-01

    In order to study the chronology of age of third molar mineralization of Han in southern China, Demirjian staging method was used to determine the stage of four third molars (18, 28, 38, 48) mineralization in 3,100 Han in southern China aged 4.1-26.9 years based on radiological evidence from digital orthopantomograms. The mean age of the 3,100 patients was 15.96 +/- 4.73 years, including 1,200 male (mean age, 15.32 +/- 4.62) and 1,900 female (mean age, 16.35 +/- 4.76). Results show that there was no significant difference in mineralization between 18 and 28 and 38 and 48 of male or female. However, significant difference was observed between 28 and 38 of female at stage C; 28 was 0.25 years earlier than 38. In male, at stage G, 38 was 0.61 years earlier than 28, and 48 was 0.62 years earlier than 18. At stages D, E, F, G, and H, male 48 was 0.34, 0.66, 0.72, 1.34, and 0.76 years earlier than that of female, respectively. At stages A, D, E, F, G, and H, male 38 was 0.73, 0.26, 0.56, 0.91, 1.29, and 0.70 years earlier than that of female, respectively. At stages B, E, F, G, and H, the mineralization mean age of male 18 was 0.54, 0.50, 0.76, 0.92, and 0.58 years earlier than that of female, respectively. At stages E, F, G, and H, the mineralization mean age of male 28 was 0.51, 0.76, 0.92, and 0.49 years earlier than that of female, respectively. After reviewing the literature, the chronological mineralization age of 48, at stages D to G, of Han in southern China was 1 to 4.6 years earlier than that of Japanese and 1 to 3 years earlier than that of German. The mean age at stage H of 48 of Han in southern China was similar to Turkish, Black African, Japanese, and German, but was later than Spanish. Finally, the conclusions are: (1) in the same gender group of Han in southern China, the mineralization ages between two sides in upper or lower jaw are very similar, and (2) the chronology mean age and complete time of third molar mineralization of male were earlier than

  2. Hanxue Shangdui: A case study on the contentions between the Han School and the Song School in the middle Qing dynasty

    Institute of Scientific and Technical Information of China (English)

    Zhang Shuhong

    2006-01-01

    During the Jiaqing and Daoguang periods of the Qing dynasty,Fang Dongshu published the Hanxue Shangdui,which launched a fierce attack on the Han School and marked the open contentions between the Han and the Song schools.While defending the Song Learning.Fang attacked the shortcomings of the Han School.mainly in four aspects:the Han School's methods of scholarship,various concepts of philosophy proposed by the Han-Learning scholars,the trivial and piecemeal character,and the heterodoxy of the Han School.Fang Dongshu criticized the Han-Learning scholars who Paid attention only to the books and neglected the social affairs.Sharp and reasonable as it was,his criticism however seemed less objective,especially when he tried to use the emperor's authority to threaten the Han School,which was beyond the range of the normal academic debates.

  3. Some philology questions and history value of Hou Han Shu, which for the research the district geography in han and before han dynasty%《后汉书》对研究西汉以前政区地理的史料价值及相关文献学问题

    Institute of Scientific and Technical Information of China (English)

    辛德勇

    2012-01-01

    南朝刘宋范晔撰著的《后汉书》本纪和列传,配以西晋司马彪《续汉书》诸志,是研治东汉一朝史事最为重要的基本史料。惟研究西汉以及汉代以前各个时期的地理问题,范哗《后汉书》和包括《郡国志》在内的《续汉书》诸志,同样具有很多《汉书·地理志》以及《史记》和《汉书》其他部分所不具备的独特史料价值。%The imperial and collective biographies of Hou Han Shu compiled by Fan Ye from theLiu Song Dynasty, along with the records of Xu Han Shu compiled by Sima Biao from the Jin Dynasty, are the most important fundamental historical texts for studying the histories during the EasternHan Dynasty. Regarding the research on geographical issues before and during Han Dynasty, Fan Ye "s Hou Han Shu and Xu Han Shu including Jun Guo Zhi possess unique historical texts that Han Shuincluding its Treaties on Geography and Shiji do not have.

  4. CPPCC Vice Chairman and CPAPD President Mr.Han Qide on a good-will visit to Mexico and Argentina transit through France

    Institute of Scientific and Technical Information of China (English)

    2014-01-01

    <正>During stay in Mexico,Mr.Han Qide meets with Mr.Cervantes,President of the Senate in May 2014.Mr.Han Qide and his party attend the"Seminar on the Opportunities and Challenges in China-Mexico Cooperation".Mr.Han Qide meets with persons in charge of the Ministry of Health of Mexico.Mr.Han Qide visits the Mexican Council on Foreign Relations.

  5. Quines empreses han aguantat millor la crisi, les empreses familiars o les no familiars?

    Directory of Open Access Journals (Sweden)

    Jose Luis Gallizo

    2014-12-01

    Full Text Available Objecte: En aquest estudi és porta a terme un anàlisi comparatiu sobre l’evolució de l’estructura econòmica i financera que presenten les empreses familiars i no familiars de Catalunya en un context d’intensa crisi econòmica. La seva finalitat és poder donar resposta a dos qüestions principals: identificar les característiques diferencials de l’EF respecte a l’EnF i comprovar si aquestes característiques diferencials han permès a les EF aguantar millor la crisi econòmica. Disseny/metodologia: S’ha analitzat una mostra de 750 grans i mitjanes empreses de Catalunya (550 familiars i 200 no familiars durant el període 2008-2012. Les dades s’han obtingut a través de la base de dades SABI, i per a la classificació de les empreses en familiars i no familiars s’ha dut a terme una comprovació individual de cadascuna d’elles per evitar habituals errors de classificació. Posteriorment les empreses s’han classificat en funció de la seva dimensió per dotar d’una major robustes els resultats. També s’ha procurat que la distribució d’empreses per sectors fos similar en les diferents categories per evitar que un efecte sectorial pogués tergiversar els resultats de l’estudi. Aportacions i resultats: L’estudi ha permès constatar les hipòtesis establertes sobre el finançament de les empreses familiars i concloure que aquestes presenten una estructura financera diferent a les Empreses no familiars. Les empreses familiars als seus balanços, presenten un major nivell d’autofinançament gràcies a la seva menor distribució de dividends. A més a més, les EF presenten millors resultats en quant a nivells de cobertura i liquiditat, ja que es troben més capitalitzades i presenten uns nivells d’endeutament inferior que les Empreses no familiars. Aquestes característiques patrimonials i financeres han contribuït a que les empreses familiars aguantin millor els anys de crisi, produint-se durant aquests anys

  6. Association of TSHR gene polymorphisms and haplotypes with Graves’ disease in Han population from coastal areas in Shandong province

    Institute of Scientific and Technical Information of China (English)

    王海丽

    2013-01-01

    Objective To investigate the association of thyroid stimulating hormone receptor(TSHR)gene polymorphisms and haplotypes with Graves’disease(GD)in Han population from coastal areas in Shandong province

  7. On the Inscriptions of Han Period Pictorial Stones%汉代画像石榜题略论

    Institute of Scientific and Technical Information of China (English)

    杨爱国

    2005-01-01

    Inscriptions on the Han period pictorial stones, as this sort of relief itself, are broadly distributed across the country. With extensively involving contents, they present one aspect of the change of the mourning concept in the Han period and reflect the intensify of care for living people. They tell of the existence of folk versions on historical figures' careers beyond history books written in biographical style. Meanwhile, they provide a standard for the chronological study of Han pictorial stones.The official positions mentioned in these inscriptions can be used in comparative study of archaeological and literal evidence to supply omission in historical documents and especially to correct errors in textual records. It is known from pictorial stone inscriptions that there already existed the official position of Mt.Tai governor in the Eastern Han period.

  8. Adsorption and decomposition of monopropellant molecule HAN on Pd(100) and Ir(100) surfaces: A DFT study

    Science.gov (United States)

    Banerjee, Sourav; Shetty, Sharath A.; Gowrav, M. N.; Oommen, Charlie; Bhattacharya, Atanu

    2016-11-01

    We have performed density functional theory calculations with the generalized gradient approximation to investigate the catalytic decomposition reactions of one of the most promising monopropellants, hydroxylammonium nitrate (HAN), on two catalytically active single crystal Pd(100) and Ir(100) surfaces, aiming at exploring different reaction pathways and reactivities of these two surfaces towards the catalytic decomposition of HAN. We find that the HAN molecule binds both the Pd(100) and Ir(100) surfaces molecularly in different orientations with respect to the surface. The HONO elimination is found to possess the lowest activation energy on the Pd(100) surface; whereas, NO2 elimination is predicted to show the lowest activation energy on the Ir(100) surface. Exothermicities associated with different reaction steps are also discussed. This is the first theoretical report on the catalytic decomposition reactions of the HAN molecule on the single crystal Pd(100) and the Ir(100) surfaces using the periodic DFT calculations.

  9. Sequence analysis and functional study of the Han Nationality glial cell line-derived neurotrophic factor transcript

    Institute of Scientific and Technical Information of China (English)

    CHEN Zhe-yu; HUANG Ai-jun; LU Chang-lin; WU Xiang-fu; HE Cheng

    2001-01-01

    To study the sequence and function of the glial cell line-derived neurotrophic factor (GDNF) transcript in subjects of Han nationality. Methods: The Han nationality GDNF transcript was amplified by RT-PCR and expressed by baculovirus expression system. Biological activity of the expressed product was measured by the primary culture of midbrain dopaminergic neurons. Results: There only existed the shorter GDNF transcript of 555 bp in the Han nationality. The secretory expression product of the shorter transcript in insect cells promoted the survival and differentiation of dopaminergic neurons. Conclusion: It is found that there is a 78 bp deletion in the Han nationality GDNF transcript compared with the reported 633 bp GDNF transcript. The 78 bp deletion does not affect the secretory expression and biological activity of GDNF mature protein.

  10. His Excellency Mr Hans Brattskar, Ambassador and Permanent Representative of Norway to the United Nations Office, visiting CERN

    CERN Multimedia

    AUTHOR|(CDS)2099575

    2016-01-01

    Ambassador Hans Brattskar signing the guest book with Director for international relations Charlotte Warakaulle and Director-General Fabiola Gianotti; Deputy Permanent Representative and Minister Kjersti Sommerset and CERN Advisers Pippa Wells and Jens Vigen are also present.

  11. Pain management using Han's acupoint nerve stimulator combined with patient-controlled analgesia following neurosurgery A randomized case control study

    Institute of Scientific and Technical Information of China (English)

    Junming Ye; Zuyu Zhu; Cheng Huang; Jun Wei

    2008-01-01

    BACKGROUND:Han's acupoint ncwve stimulator(HANS)has been frequently used to relieve pain by promoting the central ncrvve system's release of endogenous opioid peptides through electric stimulation to the body surface.OBJECTIVE:To investigate the pain-relieving effects of HANS,combined with patient-controlled analgesia,following neurosurgery,and to observe adverse reactions and effects.DESIGN,TIME AND SETTING:A randomized centrel observation was performed at the Department of Neurology in the First Affiliated Hospital of Gannan MeScal College(Ganzhou,Jiangxi Province,China)from January 2005 to February 2006.PARTICIPANTS:Forty patients,who were selected for craniotomy and required pain relief following surgery at the Department of Neurology in the First Affiliated Hospital of Garman Medical College(China),were included in this study.METHODS:Forty patients underwent neurosurgery and were randomly divided into two groups:patient-controlled analgesia plus HANS(+HANS,n=20)and patient-controlled analgesia(-HANS,n=20).Both groups were well matched in baseline data.Automatic syringe infusion pump ZZB-150 was the product of Nantong Aipeng Medical Instruments Co.,Ltd.(China).Patient-controlled analgesia consisted of 100 mL 0.02% lappaconitine/0.02% metoclopramide.LH-402 HANS instrument was produced in Beijing(China),with a serial number of 402183.The HANS instrumentation was used to stimulate the Hegu-Laogong acupoint on one side and Jiaogan,Shenmen penetrating Shen,Waifei,Naogan penetrating Pizhixia ear acupoints on the affected side for one hour,with 2-hour intervals.The disperse-dense wave was alternating,with a 2/100 Hz frequency of dectrical stimulation.MAIN OUTCOME MEASURE:The scores of visual analogue scale and incidence of adverse reaction were observed in two groups following surgery.RESULTS:Compared with the-HANS group,the visual analogue scale scores were remarkably lower in the+HANS group six hours after surgery(P<0.01),and the incidence rate of adverse reactions

  12. Evaluation of the genetic parameters and mutation analysis of 22 STR loci in the central Chinese Han population.

    Science.gov (United States)

    Hongdan, Wang; Bing, Kang; Ning, Su; Miao, He; Bo, Zhang; Yuxin, Guo; Bofeng, Zhu; Shixiu, Liao; Zhaoshu, Zeng

    2017-01-01

    At present, the Han nationality is China's main ethnic group and also the most populous nation in the world. This is a great resource to study microsatellite mutations and for the study of ethnogeny. The aim of this study is to investigate the genetic polymorphisms and mutations of 22 autosomal STR loci in 2475 individuals from Henan province, China. DNA is amplified and genotyped using PowerPlex™24 system. The gene frequencies, forensic parameters, and the mutation rate of the 22 STR loci are analyzed. A total of 295 alleles are observed in this Henan Han population, and the allelic frequencies ranged from 0.0003 to 0.5036. In order to investigate the genetic relationships between the Henan Han and the other 14 different populations, our present data were compared with previously published data for the same 15 STR loci. The results indicated that the Henan Han had closer genetic relationships the groups including Minnan Han, Maonan, Yi and Guangdong Han groups while the South morocco population, the Moroccan population, the Malay group, and the Uigur stand away from Henan Han. Except of D2S441, D13S317, PentaE, D2S1338, D5S818, TPOX and D19S433, the mutation events are found in the other 15 STR loci. A total of 40 mutation events are observed in the 15 STR loci. The mutation rates are ranged from 0 to 4.85 × 10(-3). In this study, 39 mutations are single-step mutations, and only one at FGA comprised two steps. STR mutation is commonly existed in paternity testing, while there are no STR mutation studies of the 22 STR loci in the Henan Han population. It is of great importance in forensic individual discrimination and paternal testing.

  13. Familial correlation and aggregation of body mass index and blood pressure in Chinese Han population.

    Science.gov (United States)

    Hu, Yang; He, Liu; Wu, Yangfeng; Ma, Guansheng; Li, Liming; Hu, Yonghua

    2013-07-26

    It remains unclear whether the body mass index (BMI) and blood pressure (BP) profile are clustered within families in Chinese Han population. The aim of this study is to explore familial aggregation and parent-offspring correlations of BMI and blood pressure in Chinese Han population. 6,369 Han nucleus families, consisting of parents and at least one biological adult child who were living together, were enrolled from the nation-wide cross-sectional study (China National Nutrition and Health Survey) which was conducted in 2002, with a total number of 19,107 participants aged 18-64 years (6,369 sets of parents, 4,132 sons and 2,237 daughters). Family aggregation (Intra-class correlations, ICCs) and parent-offspring correlations in BMI, systolic BP (SBP) and diastolic BP (DBP) were estimated using linear mixed effect regression models. BMI and BP levels in two generations and ICCs of BMI, SBP and DBP varied across the country. Familial aggregation of overweight/obesity was observed in rural area (ICC=5.4%, pfamilies (ICC=4.4%, pfamilies (ICC=2.6%). Additionally, offspring with more parents being overweight/obese tend to have higher BMI. The similar trend was found for high BP. However, we did not observe that same-sex parent-offspring correlations of BMI and BP were stronger than the correlations for mother-son or father-daughter. Our study suggested that familial environments, alongside the impact of genetic factors, could be important non-communicable chronic diseases (NCD) risk factors. Family-based intervention taking both mother and father into account might have great potential in NCD prevention for younger generation.

  14. Association study of ankylosing spondylitis and polymorphisms in ERAP1 gene in Zhejiang Han Chinese population.

    Science.gov (United States)

    Liu, Yangbo; Li, Liangda; Shi, Shanfen; Chen, Xin; Gao, Jianqing; Zhu, Minyu; Yuan, Jiandong

    2016-02-01

    The susceptibility loci of ERAP1 polymorphisms have been found to be strongly associated with ankylosing spondylitis (AS). The researches in multiple ethnic cohorts suggested that the population attributable risk in ERAP1 polymorphisms is at a high significance level. This study was undertaken to estimate the prevalence and incidence of subsets of AS and investigate the specific variants of ERAP1 polymorphisms in AS susceptibility, in the Han ethnic Chinese population in Zhejiang Province. AS patients were selected, diagnosed, and confirmed by a qualified rheumatologist. The basal clinical and demographic characteristics were compared with all subjects. Genotypes for eight selected single nucleotide polymorphisms (SNPs) in ERAP1 gene (rs27038, rs27037, rs27434, rs27980, rs7711564, rs30187, rs10050860, and rs17482078) were determined by using the Sequenom MassARRAY iPLEX platform in Zhejiang Han Chinese population. Association analyses were performed on the whole genotyped data set in 707 unrelated ankylosing spondylitis cases and 837 ethnically matched controls. We observed the strongest association between AS and HLA-B27, which confers over 90 % of ankylosing spondylitis cases. Moreover, we found three loci of ERAP1 polymorphisms were at a high significance level (rs27037 P = 0.00451; rs27434 P = 0.00012; rs27980 P = 0.00682) with AS in Zhejiang population. We also confirmed polymorphism locus of ERAP1 previously reported association with AS (rs27434; P = 5.3 × 10(-12)). Our results indicated a difference in the mechanism of susceptibility loci in subsets of Zhejiang Han Chinese population and provided further evidence that rs27434 is the key polymorphism associated with AS in ERAP1 gene.

  15. Association Study of IL-12B Polymorphisms Susceptibility with Ankylosing Spondylitis in Mainland Han Population.

    Directory of Open Access Journals (Sweden)

    Li Zhang

    Full Text Available This study aims to determine whether the genetic polymorphisms of IL-12B gene is a susceptibility factor to Ankylosing spondylitis (AS in mainland Han Chinese population.Eight single-nucleotide polymorphisms (SNPs (rs10045431, rs11167764, rs3212227, rs6556412, rs6556416, rs6871626, rs6887695 and rs7709212 in the IL-12B gene were genotyped by iMLDR Assay technology in 400 patients [96% (384/400 HLA-B27(+] and 395 geographically and ethnically matched healthy controls in mainland Han Chinese population. The correlation between IL-12B genetic polymorphisms and AS activity index (BASDAI, BASFI were tested.The significant difference was found in genotype distribution between AS and healthy controls (χ2 = 6.942, P-value = 0.031 of the SNP rs6871626. Furthermore, significant evidence was also detected under the recessive model for minor allele A. The AA genotype carrier had 1.830 fold risk compared with C allele carrier (with CC and AC genotypes [OR (95% CI = 1.830 (1.131-2.961, P-value = 0.014]. Nevertheless, the difference was no longer significant after Bonferroni correction. Subset analysis on cases with HLA-B27(+ did find the same results. Three genotypic groups (AA, CC and CA in rs6871626 site was highly associated with the BASDAI and BASFI (P-value = 0.012 and P-value = 0.023, respectively, after adjustment for effect of age, sex, and disease duration, the P-value was 0.031 and 0.041, respectively. The AA genotype of rs6871626 was also significantly correlated with an increased BASDAI and BASFI compared to the AC and CC genotypes in AS patients.Our findings suggest that rs6871626 may be associated AS susceptibility and with disease activity (BASDAI, BASFI in mainland Han Chinese population.

  16. Vitamin D binding protein variants associate with asthma susceptibility in the Chinese han population

    Directory of Open Access Journals (Sweden)

    Zhang Youming

    2011-08-01

    Full Text Available Abstract Background Asthma is a genetically heterogeneous disease. Polymorphisms of genes encoding components of the vitamin D pathway have been reported to associate with the risk of asthma. We have previously demonstrated that vitamin D status was associated with lung function in Chinese asthma patients. In this study, we tested whether polymorphisms of genes encoding for vitamin D receptor (VDR, vitamin D 25-hydroxylase (CYP2R1 and vitamin D binding protein (GC were associated with asthma in the Chinese Han population. Methods We sequenced all 8 exons of VDR and all 5 exons of CYP2R1 in a Chinese case-control cohort of asthma consisting of 467 cases and 288 unrelated healthy controls. Two mutations were identified in these regions. These variants were specified as rs2228570 in exon 2 of VDR and rs12794714 in exon 1 of CYP2R1. We also genotyped two common polymorphisms in GC gene (rs4588 and rs7041 by a PCR-restriction fragment length polymorphism (RFLP method. We analyzed the association between these 4 polymorphisms and asthma susceptibility and asthma-related traits. Results Polymorphic markers in VDR and CYP2R1 were not associated with asthma in the Chinese Han cohort. Importantly, variants in GC gene, which give rise to the two most common electrophoretic isoforms of the vitamin D binding protein, were associated with asthma susceptibility. Compared with isoform Gc1, Gc2 was significantly associated with the risk of asthma (OR = 1.35, 95% CI = 1.01-1.78 p = 0.006. Conclusions The results provide supporting evidence for association between GC variants and asthma susceptibility in the Chinese Han population.

  17. Environmental Risk Factors in Han and Uyghur Children with Dyslexia: A Comparative Study.

    Directory of Open Access Journals (Sweden)

    Hua Zhao

    Full Text Available Several studies have been conducted to explore risk factors for dyslexia. However, most studies examining dyslexia have been skewed toward Western countries, and few have considered two nationalities simultaneously. This study focused on differences in dyslexia prevalence and potential environmental risk factors between Han and Uyghur children.A cross-sectional study was conducted in Kashgar and Aksu, cities in Xinjiang province, China. A two-stage sampling strategy was used to recruit 2,854 students in grades 3-6 from 5 primary schools in 5 districts; 2,348 valid student questionnaires were included in the analysis. Dyslexia checklists for Chinese and Uyghur children and pupil rating scales were used to identify children with dyslexia. Questions related to the home literacy environment and reading ability were used to evaluate potential environmental risk factors. Single factor analysis and multivariate logistic regression were used to examine prevalence and risk factors for dyslexia.Dyslexia prevalence differed significantly between Han (3.9% and Uyghur (7.0% children (P < 0.05, and the boy-to-girl diagnosis ratio was almost 2:1. Multiple logistic regression analysis showed that ethnic differences in dyslexia prevalence between Han and Uyghur children could have occurred because of factors such as mother's occupation (P = 0.02, OR = 0.04, 95% CI = 0.01-0.68 and the frequency with which parents told stories (P = 0.00, OR = 4.50, 95% CI = 1.67-12.11.The prevalence of dyslexia was high in all children, particularly those in the Uyghur group. Environmental factors could have been responsible for some of the differences observed. The results contribute to the early identification and management of dyslexia in children from these two groups and research examining developmental dyslexia and differences in racial genetics.

  18. Environmental Risk Factors in Han and Uyghur Children with Dyslexia: A Comparative Study

    Science.gov (United States)

    Zhao, Hua; Zhang, Baoping; Chen, Yun; Zhou, Xiang

    2016-01-01

    Background Several studies have been conducted to explore risk factors for dyslexia. However, most studies examining dyslexia have been skewed toward Western countries, and few have considered two nationalities simultaneously. This study focused on differences in dyslexia prevalence and potential environmental risk factors between Han and Uyghur children. Methods A cross-sectional study was conducted in Kashgar and Aksu, cities in Xinjiang province, China. A two-stage sampling strategy was used to recruit 2,854 students in grades 3–6 from 5 primary schools in 5 districts; 2,348 valid student questionnaires were included in the analysis. Dyslexia checklists for Chinese and Uyghur children and pupil rating scales were used to identify children with dyslexia. Questions related to the home literacy environment and reading ability were used to evaluate potential environmental risk factors. Single factor analysis and multivariate logistic regression were used to examine prevalence and risk factors for dyslexia. Results Dyslexia prevalence differed significantly between Han (3.9%) and Uyghur (7.0%) children (P boy-to-girl diagnosis ratio was almost 2:1. Multiple logistic regression analysis showed that ethnic differences in dyslexia prevalence between Han and Uyghur children could have occurred because of factors such as mother’s occupation (P = 0.02, OR = 0.04, 95% CI = 0.01–0.68) and the frequency with which parents told stories (P = 0.00, OR = 4.50, 95% CI = 1.67–12.11). Conclusions The prevalence of dyslexia was high in all children, particularly those in the Uyghur group. Environmental factors could have been responsible for some of the differences observed. The results contribute to the early identification and management of dyslexia in children from these two groups and research examining developmental dyslexia and differences in racial genetics. PMID:27416106

  19. The association between common genetic variation in the FTO gene and metabolic syndrome in Han Chinese

    Institute of Scientific and Technical Information of China (English)

    WANG Tong; ZHANG Li-li; ZHANG Yun; SUN Xiao-fang; ZHANG Qian; HUANG Yi; XIAO Xin-hua; WANG Duen-mei; DIAO Cheng-ming; ZHANG Feng; XU Ling-ling; ZHANG Yong-biao; LI Wen-hui

    2010-01-01

    Background Genome-wide association studies for type 2 diabetes mellitus (T2DM) identified FTO gene as a locus conferring increased risk for common obesity in many populations with European ancestry. However, the involvement of FTO gene in obesity or T2DM related metabolic traits has not been consistently established in Chinese populations. The objective of this study was to investigate the association of FTO genetic polymorphisms with metabolic syndrome (MetS) in Han Chinese.Methods We tested 41 FTO single nucleotide polymorphisms (SNPs) for association between FTO and MetS-related traits. There were a total of 236 unrelated subjects (108 cases and 128 controls), grouped according to the International Diabetes Federation (IDF) criteria.Results Of the 41 SNPs examined, only SNP rs8047395 exhibited statistical significance (P=0.026) under a recessive model, after Bonferroni adjustment for multiple testing (OR 1.64, 95% CI 1.11-2.42; P=0.014). The common distributions of this polymorphism among Chinese-with a minor allele frequency (MAF) of 36% in the control group versus 48% in the MetS group-greatly improved our test power in a relatively small sample size for an association study. Previously identified obesity-(or T2DM-) associated FTO SNPs were less common in Han Chinese and were not associated with MetS in this study. No significant associations were found between our FTO SNPs and any endophenotypes of MetS.Conclusions A more common risk-conferring variant of FTO for MetS was identified in Han Chinese. Our study substantiated that genetic variations in FTO locus are involved in the pathogenesis of MetS.

  20. LBP and CD14 polymorphisms correlate with increased colorectal carcinoma risk in Han Chinese

    Institute of Scientific and Technical Information of China (English)

    Rui Chen; Fu-Kang Luo; Ya-Li Wang; Jin-Liang Tang; You-Sheng Liu

    2011-01-01

    AIM: To explore the associations of polymorphisms of lipopolysaccharide binding protein (LBP), cluster of differentiation 14 (CD14), toll-like receptor 4 (TLR-4), interleukin-6 (IL-6) and tumor necrosis factor α (TNF-α) with the colorectal carcinoma (CRC) risk in Han Chinese. METHODS: Polymorphisms of LBP (rs1739654, rs2232596, rs2232618), CD14 (rs77083413, rs4914), TLR-4 (rs5030719), IL-6 (rs13306435) and TNF-α (rs35131721) were genotyped in 479 cases of sporadic colorectal carcinoma and 486 healthy controls of Han Chinese in a case-control study. Single-nucleotide polymorphisms (SNPs) between cases and controls were analyzed by unconditional logistic regression. RESULTS: GA and GG genotypes of LBP rs2232596 were associated with a significantly increased risk of CRC [odds ratio (OR) = 1.51, 95% confidence interval (CI) 1.15-1.99, P = 0.003; OR = 2.49, 95% CI 1.16-5.38, P = 0.016, respectively]. A similar association was also observed for the CG genotype of CD14 rs4914 (OR= 1.69, 95% CI 1.20-2.36, P = 0.002). In addition, a combination of polymorphisms in LBP rs2232596 and CD14 rs4914 led to a 3.4-fold increased risk of CRC (OR = 3.44,95% CI 1.94-6.10, P = 0.000).CONCLUSION: This study highlights the LBP rs2232596 and CD14 rs4914 polymorphisms as biomarkers for elevated CRC susceptibility in the Chinese Han population.

  1. HLA-G coding region and 3'untranslated region (3'UTR) in two Chinese Han populations.

    Science.gov (United States)

    Wang, Wen Yi; Tian, Wei; Liu, Xue Xiang; Li, Li Xin

    2016-08-01

    In this study, exons 2-4 and 3'untranslated region (3'UTR) of human leukocyte antigen (HLA)-G gene were investigated for 201 and 104 healthy unrelated Han samples recruited from Hunan Province, southern China and central Inner Mongolia Autonomous Region, northern China, respectively, using sequence-based typing and cloning methods. Totally 12 HLA-G alleles in the coding region, 9 variable sites in 3'UTR, 8 3'UTR haplotypes and 15 HLA-G extended haplotypes (EHs) incorporating the coding region and 3'UTR were observed. Very strong linkage disequilibrium (LD) was observed between HLA-A and HLA-G, and between HLA-G coding region and 3'UTR in each population (all global P=0.0000). Seven HLA-A-G haplotypes showed significant LD in both populations. Three HLA-G alleles in the coding region, 4 polymorphic sites in the 3'UTR, 3 3'UTR haplotypes and 4 HLA-G EHs differed significantly in their distributions between the 2 Chinese Han populations (all P≤0.0001). There was evidence for balancing selection acting on HLA-G 3'UTR positions +3010, +3142 and +3187 in the two populations. The NJ dendrograms demonstrated the existence of two basic HLA-G lineages and indicated that, HLA-G*01:01:01, the most common HLA-G allele, formed a separate lineage from other alleles. Our results shed new lights into HLA-G genetics among Chinese Han populations. The findings reported here are of importance for future studies related to post-transcriptional regulation of HLA-G allelic expression and the potential role of HLA-G in disease association in populations of Chinese ancestry.

  2. Mitochondrial DNA haplogroup R in the Han population and recovery from septic encephalopathy.

    Science.gov (United States)

    Yang, Yi; Zhang, Ping; Lv, Rong; He, Qiang; Zhu, Yiling; Yang, Xianghong; Chen, Jianghua

    2011-10-01

    To determine whether the main mitochondrial DNA (mtDNA) haplogroups of the Han people are associated with neurological recovery from septic encephalopathy. We studied 137 individuals with septic encephalopathy who were sequentially admitted to the intensive care unit or the emergency intensive care unit at the First Affiliated Hospital, College of Medicine, Zhejiang University, and the People's Hospital of Zhejiang Province. Demographic and clinical data were recorded along with clinical outcome over 28 days. The Glasgow coma scale (GCS) score was calculated daily until it reached 15 or until the patient died during the 28-day period. Follow-up was completed for all study participants. We then determined the mtDNA haplogroups of the patients by analyzing sequences of hypervariable mtDNA segments and testing diagnostic polymorphisms in the mtDNA coding region with DNA probes. MtDNA haplogroup R, one of the main mtDNA haplogroups of the Han people, was a strong independent predictor of outcome following septic encephalopathy, conferring a 4.053-fold (95% CI 1.803-9.110, p = 0.001) increased chance of neurological recovery within 28 days compared with those with a non-R mtDNA haplogroup. In the Han population, mtDNA haplogroup R is a strong independent predictor of the outcome of septic encephalopathy, conferring an increased chance of neurological recovery compared with individuals with a non-R haplogroup. Our results provide potential insights into the mechanisms involved in septic encephalopathy, and reveal that the mtDNA haplogroup R is an independent predictor of the outcome of septic encephalopathy.

  3. La discreta y sorprendente vigencia del ideólogo del despotismo chino: Han Feizi

    Directory of Open Access Journals (Sweden)

    Conde, Juan Luis

    2016-06-01

    Full Text Available Han Feizi (3rd century B.C. is the main representative of the Chinese Legalist school (făjiā. The tenets of this political theory have earned him the nickname “the Chinese Machiavelli”. His ideas were adopted by Qin Shihuang, the so-called First Emperor, who unified China and unleashed a despotic régime characterized by the crackdown of any political debate and the suppression of free speech. The connexion between rhetorical development and the political sphere in the context of Classical China’s last stage may set the scene for a wider discussion about that link. Comparative rhetoric will provide further ground for connexions between classical Chinese Legalist ideas and contemporary Neoliberal discourse.Han Feizi (s. III a.C. es el principal representante de la escuela legista china (făjiā. Los principios de su teoría política le han granjeado el apodo de “el Maquiavelo chino”. Sus ideas serían adoptadas por Qin Shihuang, el Primer Emperador, quien unificó China e impuso un régimen despótico caracterizado por la represión del debate político y la supresión de la libertad de expresión. La conexión entre el desarrollo de la retórica y la situación política en el contexto de la última etapa del clasicismo chino puede servir de fondo para una consideración más amplia de dicho nexo. La retórica comparada proporciona las bases para relacionar el pensamiento legista chino con el discurso neoliberal contemporáneo.

  4. Caso de estudio sobre apropiación de SCRUM en empresas que han adoptado CMMI

    OpenAIRE

    2013-01-01

    Actualmente la industria de software local se enfrenta a una situación interesante: de una parte se evidencia un auge en la adopción de las prácticas ágiles, que buscan encontrar mejores formas de trabajo de los equipos de desarrollo de software y, de otra parte, algunas de estas industrias, ya han realizado proyectos de mejora de procesos utilizando CMMI como el modelo referente, e incluso algunas de estas compañías cuentan con valoraciones oficiales de madurez en niveles 2, 3 y superiores -...

  5. Adding a Capability to Extract Sentiment from Text Using HanDles

    Science.gov (United States)

    2012-05-01

    Minister of National Defence, 2012 © Sa Majesté la Reine (en droit du Canada), telle que représentée par le ministre de la Défense nationale, 2012...HanDles afin qu’il fasse la distinction entre bonnes et mauvaises critiques de film. Nous avons exécuté ce scénario à trois reprises dans le but de...vérifier à quel point il parvient à classifier correctement les documents. Le premier essai portait sur des critiques de l’appareil Kindle d’Amazon

  6. Genetic Variants at 20p11 Confer Risk to Androgenetic Alopecia in the Chinese Han Population

    OpenAIRE

    Bo Liang; Chunjun Yang; Xianbo Zuo; Yang Li; Yantao Ding; Yujun Sheng; Fusheng Zhou; Hui Cheng; Xiaodong Zheng; Gang Chen; Zhengwei Zhu; Jun Zhu; Xuhui Fu; Tao Wang; Ying Dong

    2013-01-01

    BACKGROUND: Androgenetic alopecia (AGA) is a well-characterized type of progressive hair loss commonly seen in men, with different prevalences in different ethnic populations. It is generally considered to be a polygenic heritable trait. Several susceptibility genes/loci, such as AR/EDA2R, HDAC9 and 20p11, have been identified as being involved in its development in European populations. In this study, we aim to validate whether these loci are also associated with AGA in the Chinese Han popul...

  7. ELEMENTOS PARA PENSAR A CRISE DA RACIONALIDADE OCIDENTAL - O CAMINHO DE HANS JONAS E DE LEVINAS

    Directory of Open Access Journals (Sweden)

    Flaviano Fonseca

    2012-07-01

    Full Text Available Este artigo destaca a importância de pensar a racionalidade ocidental a partir dacategoria da alteridade e da responsabilidade ética. A razão instrumental colaborousignificativamente para com a profunda crise pela qual passa a nossa racionalidade ocidental.Hans Jonas propõe uma nova ética nesta época em que somos chamados a escolher o nossofuturo. Isso implica refletir sobre a questão do ser (humano e não humano como fim em simesmo, pois somos uma comunidade terrestre com um destino comum.

  8. NO ASSOCIATION BETWEEN TUMOR NECROSIS FACTOR ALPHA AND OBSESSIVE COMPULSIVE DISORDER IN CHINESE HAN POPULATION

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Objective To investigate association between tumor necrosis factor alpha (TNF-α) and obsessive compulsive disorder (OCD) in Chinese Han population.Methods Plasma concentrations of TNF-α were measured in 61 drug-free patients who fulfilled DSM-Ⅳ criteria for OCD and 93 healthy controls.TNF-α concentrations in blood were determined by enzyme-linked immunosorbent assay (ELISA).Two polymorphisms of TNF-α gene were investigated in the same patients and healthy controls:-308 G/A and-238 G/A.The allelic and genoty...

  9. Hans Christian Andersen's spelling and syntax: Allegations of specific dyslexia are unfounded

    DEFF Research Database (Denmark)

    Kihl, Preben; Gregersen, K.; Sterum, N.

    2000-01-01

    Sources contemporary with Danish author Hans Christian Andersen claimed that he did not master the Danish Language, which modern studies interpret as specific dyslexia. A systematic study of his diaries from age 20 to 70 found a mean spelling error percentage of approximately 1.7 (SD=1%, range 0...... and 15 times lower than the mean percentages in studies of individuals with dyslexia. A structural analysis of Andersen's spelling errors shows that they are mainly phonologically plausible from ages 11 to 70, and that the proportion of phonologically plausible/implausible errors match those of normal...... achievers, but not those of individuals with dyslexia....

  10. [Sigmund Freud and Hans Blüher in up to now unpublished letters].

    Science.gov (United States)

    Neubauer, J

    1996-02-01

    In the years 1912 and 1913 there occured an epistolary encounter between the founder-father of psychoanalysis and the young Hans Bluher who had been active in the Wandervogel movement, a German youth movement with strong traditionalist and nationalist leanings. Their correspondence centered around the evaluation of male homosexuality, a point on which Freud and Bluher were not in entire agreement. In his introduction Neubauer outlines the intellectual nub of this debate and sketches Bluher's later career and his gradual transformation into a biologistically motivated anti-Semite completely and utterly disowned by Freud.

  11. HANS BELLMER, UN ARTISTE PHILOSOPHE OU L'IDENTITE EN QUESTION

    Directory of Open Access Journals (Sweden)

    MARYVONNE PERROT

    2013-05-01

    Full Text Available If the surrealist group has attracted the interest of philosophers, one can also note that some of these artists have attempted to develop their own philosophical reflection. This was the case of Hans Bellmer obsessed with the themes of desire, body and metamorphosis and, through that, with the games of identity and otherness. The anatomy of the image, one of Bellmer’s essential books, also shows the role of the artistic creation in the efforts to illuminate the “enigma of existence”.

  12. Experiencia e historicidad en la hemenéutica de hans-georg gadamer

    OpenAIRE

    Mancilla Muñoz, Mauricio

    2013-01-01

    Se busca mostrar la mutua correspondencia entre experiencia e historicidad en la obra de Hans-Georg Gadamer. La experiencia es entendida como el movimiento fundamental de la existencia histórica, la cual articula las diversas esferas de la acción humana. La experiencia hermenéutica pone de manifiesto que el comprender no puede fundarse en un procedimiento metódico, sino en la forma del existir situado en el mundo. El acto hermenéutico es entendido como un continuo proceso de apropiación, que ...

  13. Vision improvement in a Taiwanese (Han Chinese) family with Leber's hereditary optic neuropathy.

    Science.gov (United States)

    Lin, Hong-Zin; Pang, Cheng-Yoong; Chen, Shee-Ping; Tsai, Rong-Kung

    2012-12-01

    In this report, we describe a Taiwanese (Han Chinese) family with Leber's hereditary optic neuropathy. The family carried a mitochondrial DNA mutation (mtDNA m.14484T>C) associated with spontaneous visual improvement. A 15-year-old boy from this family was diagnosed with Leber's hereditary optic neuropathy 6 months after losing his vision. His vision recovered after 8 months of supportive treatment. His mother, older brother, and two sisters also had the same mutation and had previously experienced vision loss. In this family, there was no male predominance.

  14. Detecting the polymorphism sites of p53 and Fas genes of Han population in Zhejiang province

    Institute of Scientific and Technical Information of China (English)

    Yang Zhuo; Xingye Zeng; Dadao Huang; Xuexue Zhou

    2006-01-01

    BACKGROUND: It is of significance for single nucleotide polymorphisms (SNPs),a difference of rank, which exists widely in biology, genetics and other fields.OBJECTIVE: To detect polymorphism sites in exon-4 of p53 gene, promotor of Fas gene and intron-7 of Fas gene of healthy people in Han nationality in Zhejiang province.DESIGN: Simple random sampling.SETTING: Department of Surgery of the 118 Hospital of Chinese PLA.PARTICIPANTS: A total of 80 healthy people in Han nationality were selected from hospitals in Zhejiang province from August 2005 to January 2006. There were 43 males and 37 females aged from 3 to 78 years with the mean age of 39.5 years, and all subjects were consent. DNA which was used in genetic analysis was selected from peripheral venous blood of all subjects and maintained at -20 ℃.METHODS: Polymorphism sites in exon-4 of p53 gene, promotor of Fas gene and intron-7 of Fas gene were detected with directly DNA sequencing technique.MAIN OUTCOME MEASURES: Polymorphism sites in exon-4 of p53 gene, promotor of Fas gene and intron-7 of Fas gene of healthy people in Han nationality in Zhejiang province.RESULTS: A total of 80 samples were involved in the final analysis. SNPs sites were found at the 119th base of exon-4 of p53 gene (the 72nd codon of p53 gene), the 670th base of upper start codon in promotor of Fas gene (Fas-670), and the 995th base of intron-7 of Fas gene, especially SNPs in the 995th base of intron-7 pf Fas gene, I.e. C→A transversion, was a new site.CONCLUSION: One unknown SNPs site is discovered in intron-7 of Fas gene of people in Han nationality in Zhejiang province. This study also proves that the 72nd codon exists in p53 gene and the -670 polymorphism site exists in promotor of Fas gene.

  15. Mitochondrial DNA Haplogroups and the Risk of Sporadic Parkinson's Disease in Han Chinese

    Institute of Scientific and Technical Information of China (English)

    Ya-Fang Chen; Wan-Jin Chen; Xiao-Zhen Lin; Qi-Jie Zhang; Jiang-Ping Cai; Chia-Wei Liou; Ning Wang

    2015-01-01

    Background:Mitochondrial dysfunction is linked to the pathogenesis of Parkinson's disease (PD).However,the precise role of mitochondrial DNA (mtDNA) variations is obscure.On the other hand,mtDNA haplogroups have been inconsistently reported to modify the risk of PD among different population.Here,we try to explore the relationship between mtDNA haplogroups and sporadic PD in a Han Chinese population.Methods:Nine single-nucleotide polymorphisms,which define the major Asian mtDNA haplogroups (A,B,C,D,F,G),were detected via polymerase chain reaction-restriction fragment length polymorphism or denaturing polyacrylamide gel electrophoresis in 279 sporadic PD patients and 510 matched controls of Han population.Results:Overall,the distribution ofmtDNA haplogroups did not show any significant differences between patients and controls.However,after stratification by age at onset,the frequency of haplogroup B was significantly lower in patients with early-onset PD (EOPD) compared to the controls (odds ratio [OR] =0.225,95% confidence interval [CI]:0.082-0.619,P =0.004),while other haplogroups did not show significant differences.After stratification by age at examination,among subjects younger than 50 years of age:Haplogroup B also showed a lower frequency in PD cases (OR =0.146,95% CI:0.030-0.715,P =0.018) while haplogroup D presented a higher risk of PD (OR =3.579,95% CI:1.112-11.523,P =0.033),other haplogroups also did not show significant differences in the group.Conclusions:Our study indicates that haplogroup B might confer a lower risk for EOPD and people younger than 50 years in Han Chinese,while haplogroup D probably lead a higher risk of PD in people younger than 50 years of age.In brief,particular Asian mtDNA haplogroups likely play a role in the pathogenesis of PD among Han Chinese.

  16. Autocratic Bureacratism: Han Fei's Ancient Chinese Strategies of Governance as Contrasted with Machiavelli's Political Philosophy

    OpenAIRE

    2002-01-01

    This study is a comparative analysis of the political philosophies of the ancient Chinese thinker Han Fei (ca. 280-233 BC) and the Western Renaissance thinker Niccolò Machiavelli (AD 1469-1527). In the thought of these pioneers of strategic political thought – both notorious for their hardheaded and “realist” approach to political life – the special problems of power maintenance and political stability are focused. The strong focus on these issues in the two thinkers must be seen in the l...

  17. Hans Christian Andersen's spelling and syntax: Allegations of specific dyslexia are unfounded

    DEFF Research Database (Denmark)

    Kihl, Preben; Gregersen, K.; Sterum, N.

    2000-01-01

    Sources contemporary with Danish author Hans Christian Andersen claimed that he did not master the Danish Language, which modern studies interpret as specific dyslexia. A systematic study of his diaries from age 20 to 70 found a mean spelling error percentage of approximately 1.7 (SD=1%, range 0...... and 15 times lower than the mean percentages in studies of individuals with dyslexia. A structural analysis of Andersen's spelling errors shows that they are mainly phonologically plausible from ages 11 to 70, and that the proportion of phonologically plausible/implausible errors match those of normal...... achievers, but not those of individuals with dyslexia....

  18. Traduire la bêtise. Entretien avec Hans-Horst Henschen

    Directory of Open Access Journals (Sweden)

    Hans-Horst Henschen

    2012-03-01

    Full Text Available Quand il entreprend de traduire l’ensemble du corpus Bouvard et Pécuchet, Hans-Horst Henschen est déjà un traducteur reconnu. Ses traductions et/ou éditions de Barthes, Lévi-Strauss, Lyotard, Althusser, Michel Serres ou Jean Starobinski font de lui en Allemagne un relais important de la pensée française. Et à ces traductions d’auteurs ou de courants critiques, s’ajoutent celles qui s’y rattachent par raccroc ; celles qui semblent au contraire quitter les champs de l’anthropologie, de la psych...

  19. Hans Zimmer and James Newton Howard’s The Dark Knight: A Film Score Guide

    OpenAIRE

    Hexel, V

    2016-01-01

    Christopher Nolan’s caped crusader trilogy—Batman Begins, The Dark Knight, and The Dark Knight Rises—is considered by many to be one of the finest translations of comic book characters to the big screen. The second film in the series, The Dark Knight, was both a critical and commercial success, featuring an Oscar-winning performance by Heath Ledger as the Joker. The score—by Academy Award winner Hans Zimmer and eight-time Oscar nominee James Newton Howard—also received accolades, including a ...

  20. Annual Conference (4th) on HAN-Based Liquid Propellants. Volume 2

    Science.gov (United States)

    1989-05-01

    and J. D. Knapton, BRL, Aberdeen Proving Ground, MD 1000 Break 1020 "Quantitative Analysis of HAN-Based Liquid Propellants" by Dr. H. J. de Greiff ...Backof Dr. H. Joachin de Greiff 0721-4640-382 0721-4640-321 Rolf Hausen 0721-4640- 170 Fraunhofer- Institut-fuer K-urzzeitd3namik Ernst- Mach...6106 Ron Sasse’ Leon Decker (301) 278-6172 (301) 278-6167 Andrez Miziokel Wm F. McBratney (301) 278-6157 (301) 278-6171 227 I 4 228 DISTRIBUTION LIST No

  1. Shaping biomedical objects across history and philosophy:a conversation with Hans-Jörg Rheinberger.

    Science.gov (United States)

    García-Sancho, Miguel; González-Silva, Matiana; Jesús Santesmases, María; Rheinberger, Hans-Jörg

    2014-01-01

    Historical epistemology, according to the historian of science Hans-Jörg Rheinberger, is a space through which "to take experimental laboratory work into the realm of philosophy". This key concept, together with the crucial events and challenges of his career, were discussed in a public conversation which took place on the occasion of Rheinberger's retirement. By making sense of natural phenomena in the laboratory, the act of experimenting shapes the object; it is this shaping which became the core of Rheinberger's own research across biology and philosophy into history. For his intellectual agenda, a history of the life sciences so constructed became "epistemologically demanding".

  2. Gardens and Gateways: Journeys within the Vision of Han-shan

    Directory of Open Access Journals (Sweden)

    Anne Beidler

    2011-04-01

    Full Text Available Although rooted in the work of the T’ang poet Han-shan, this paper is ultimately about the ways in which writers and artists engage with what they experience in the world. The work of filmmaker Trin T Minh-Ha, poems by W.S. Merwin, Burtin Watson’s translations, and the thoughts on the creative process of translation by Tony Barnstone and Gary Snyder have all informed my work as an artist and the images I present here.

  3. Narrative Angle of Han Music Collection%汉乐府的叙事角度

    Institute of Scientific and Technical Information of China (English)

    谈艺超

    2012-01-01

    The first-person and the third-person narrative angles are applied in the narrative poems in Han Music Collection. The different narrative angle produces the different aesthetic effect.%汉乐府叙事诗所采用的叙事角度多为第一人称及第三人称叙事视角,也有不少作品根据情节设置的需要转换视角,不同的叙事角度产生不同的审美效果。

  4. Molecular analysis of RNF213 gene for moyamoya disease in the Chinese Han population.

    Directory of Open Access Journals (Sweden)

    Zhiyuan Wu

    Full Text Available BACKGROUND: Moyamoya disease (MMD is an uncommon cerebrovascular disorder characterized by progressive occlusion of the internal carotid artery causing cerebral ischemia and hemorrhage. Genetic factors in the etiology and pathogenesis of MMD are being increasingly recognized. Previous studies have shown that the RNF213 gene was related to MMD susceptibility in the Japanese population. However, there is no large scale study of the association between this gene and MMD in the Chinese Han population. Thus we designed this case-control study to validate the R4810K mutation and to define the further spectrum of RNF213 mutations in Han Chinese. METHODOLOGY/PRINCIPAL FINDINGS: Genotyping of the R4810K mutation in the RNF213 gene was performed in 170 MMD cases and 507 controls from a Chinese Han population. The R4810K mutation was identified in 22 of 170 MMD cases (13%, including 21 heterozygotes and a single familial homozygote. Two of the 507 controls (0.4% were heterozygous R4810K carriers. The R4810K mutation greatly increased the risk for MMD (OR = 36.7, 95% CI: 8.6~156.6, P = 6.1 E-15. The allele frequency of R4810K was significantly different between patients with ischemia and hemorrhage (OR = 5.4, 95% CI: 1.8~16.1, P = 0.001. Genomic sequencing covering RNF213 exon 40 to exon 68 also identified eight other non-R4810K variants; P4007R, Q4367L, A4399T, T4586P, L4631V, E4950D, A5021V and M5136I. Among them A4399T polymorphism was found in 28/170 cases (16.5% and 45/507 controls (8.9% and was associated with MMD (OR = 2.0, 95% CI: 1.2~3.3, P = 0.004, especially with hemorrhage (OR = 2.8, 95% CI: 1.2~6.5, P = 0.014. CONCLUSIONS: RNF213 mutations are associated with MMD susceptibility in Han Chinese. The ischemic type MMD is particularly related to the R4810K mutation. However, A4399T is also a susceptible variant for MMD, primarily associated with hemorrhage. Identification of novel variants in the RNF213 gene further highlights the genetic

  5. Ancient DNA reveals that the genetic structure of the northern Han Chinese was shaped prior to 3,000 years ago.

    Science.gov (United States)

    Zhao, Yong-Bin; Zhang, Ye; Zhang, Quan-Chao; Li, Hong-Jie; Cui, Ying-Qiu; Xu, Zhi; Jin, Li; Zhou, Hui; Zhu, Hong

    2015-01-01

    The Han Chinese are the largest ethnic group in the world, and their origins, development, and expansion are complex. Many genetic studies have shown that Han Chinese can be divided into two distinct groups: northern Han Chinese and southern Han Chinese. The genetic history of the southern Han Chinese has been well studied. However, the genetic history of the northern Han Chinese is still obscure. In order to gain insight into the genetic history of the northern Han Chinese, 89 human remains were sampled from the Hengbei site which is located in the Central Plain and dates back to a key transitional period during the rise of the Han Chinese (approximately 3,000 years ago). We used 64 authentic mtDNA data obtained in this study, 27 Y chromosome SNP data profiles from previously studied Hengbei samples, and genetic datasets of the current Chinese populations and two ancient northern Chinese populations to analyze the relationship between the ancient people of Hengbei and present-day northern Han Chinese. We used a wide range of population genetic analyses, including principal component analyses, shared mtDNA haplotype analyses, and geographic mapping of maternal genetic distances. The results show that the ancient people of Hengbei bore a strong genetic resemblance to present-day northern Han Chinese and were genetically distinct from other present-day Chinese populations and two ancient populations. These findings suggest that the genetic structure of northern Han Chinese was already shaped 3,000 years ago in the Central Plain area.

  6. MAPT as a predisposing gene for sporadic amyotrophic lateral sclerosis in the Chinese Han population

    Institute of Scientific and Technical Information of China (English)

    Pu Fang; Wenyuan Xu; Chengsi Wu; Min Zhu; Xiaobing Li; Daojun Hong

    2013-01-01

    A previous study of European Caucasian patients with sporadic amyotrophic lateral sclerosis demonstrated that a polymorphism in the microtubule-associated protein Tau (MAPT) gene was significantly associated with sporadic amyotrophic lateral sclerosis pathogenesis. Here, we tested this association in 107 sporadic amyotrophic lateral sclerosis patients and 100 healthy controls from the Chinese Han population. We screened the mutation-susceptible regions of MAPT-the 3′and 5′untranslated regions as wel as introns 9, 10, 11, and 12-by direct sequencing, and identified 33 genetic variations. Two of these, 105788 A>G in intron 9 and 123972 T>A in intron 11, were not present in the control group. The age of onset in patients with the 105788 A>G and/or the 123972 T>A variant was younger than that in patients without either genetic variation. Moreover, the pa-tients with a genetic variation were more prone to bulbar palsy and breathing difficulties than those with the wild-type genotype. This led to a shorter survival period in patients with a MAPT genetic variant. Our study suggests that the MAPT gene is a potential risk gene for sporadic amyotrophic lateral sclerosis in the Chinese Han population.

  7. Correlation of HDEFB1 polymorphism and susceptibility to chronic obstructive pulmonary disease in Chinese Han population

    Institute of Scientific and Technical Information of China (English)

    胡瑞成; 徐永健; 张珍祥; 倪望; 陈士新

    2004-01-01

    Background Inherited factors are involved in the development of chronic obstructive pulmonary disease (COPD). This study was designed to investigate the relationship between polymorphisms of HDEFB1 668 C/G and 1654G/A loci and susceptibility to COPD in Chinese Han population.Methods After the process of extracting genomic DNA from peripheral blood of COPD smokers and healthy smokers, the loci of genotypes 668C/G and 1654G/A were determined by polymerase chain reaction-restriction fragment length polymorphism analysis and polymerase chain reaction-single strand conformation polymorphism analysis. Results With respect to HDEFB1 668 locus, the occurences of CC, CG, GG genotypes were 72.7%, 25.0%, 2.3% in COPD smokers and 53.2%, 38.3%, 8.5% in healthy smokers (P<0.05, respectively). The allele frequencies of 668 C and 668G were 85.2% and 14.8% in COPD smokers and 72.3% and 27.7% in healthy smokers (P<0.01, respectively, odds ratio was 2.32 with 95% confidence interval 1.37 to 3.72). As to HDEFB1 1654G/A locus, neither genotype distribution difference nor allele distribution difference was found when comparing COPD smokers with healthy smokers. Conclusion The polymorphism of HDEFB1 668C/G is associated with susceptibility to COPD in Chinese Han population; furthermore, the 668G allele represents relatively lower susceptibility to COPD.

  8. Association between RTEL1 gene polymorphisms and COPD susceptibility in a Chinese Han population

    Science.gov (United States)

    Ding, Yipeng; Xu, Heping; Yao, Jinjian; Xu, Dongchuan; He, Ping; Yi, Shengyang; Li, Quanni; Liu, Yuanshui; Wu, Cibing; Tian, Zhongjie

    2017-01-01

    Objective We investigated the association between single-nucleotide polymorphisms in regulation of telomere elongation helicase 1 (RTEL1), which has been associated with telomere length in several brain cancers and age-related diseases, and the risk of chronic obstructive pulmonary disease (COPD) in a Chinese Han population. Methods In a case–control study that included 279 COPD cases and 290 healthy controls, five single-nucleotide polymorphisms in RTEL1 were selected and genotyped using the Sequenom MassARRAY platform. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using unconditional logistic regression after adjusting for age and gender. Results In the genotype model analysis, we determined that rs4809324 polymorphism had a decreased effect on the risk of COPD (CC versus TT: OR =0.28; 95% CI =0.10–0.82; P=0.02). In the genetic model analysis, we found that the “C/C” genotype of rs4809324 was associated with a decreased risk of COPD based on the codominant model (OR =0.33; 95% CI =0.13–0.86; P=0.022) and recessive model (OR =0.32; 95% CI =0.12–0.80; P=0.009). Conclusion Our data shed new light on the association between genetic polymorphisms of RTEL1 and COPD susceptibility in the Chinese Han population.

  9. Study of the relationship between IL-10 polymorphism and serum lipoprotein levels in Han Chinese individuals.

    Science.gov (United States)

    Yang, W Q

    2016-06-03

    Previous studies have shown that cytokines can affect serum lipoprotein concentrations. The aim of this study was to examine the association between IL-10 gene polymorphisms and serum lipoprotein levels of Han Chinese individuals. A total of 359 Han Chinese people were enrolled in this investigation. IL-10 -592, -819, and -1082 genotypes were established using polymerase chain reaction-restriction fragment length polymorphism analysis. An automatic biochemistry analyzer was used to determine serum concentrations of total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), and very low-density lipoprotein (VLDL) in each individual. We observed that the three IL-10 polymorphisms did not significantly differ in terms of age or age of carrier (P > 0.05), and the -592 and -819 variants did not significantly affect serum lipoprotein levels (P > 0.05). HDL concentrations were higher and TG levels were lower in carriers of the -1082 GA genotype compared to those with the AA genotype, and these differences were statistically significant (P 0.05). Our results suggest that the polymorphism at position -1082 in the promoter region of IL-10 may affect serum HDL and TG concentrations, while other variants of this gene appear to have no relationship with serum lipoprotein levels.

  10. Chromatin remodeling gene EZH2 involved in the genetic etiology of autism in Chinese Han population.

    Science.gov (United States)

    Li, Jun; You, Yang; Yue, Weihua; Yu, Hao; Lu, Tianlan; Wu, Zhiliu; Jia, Meixiang; Ruan, Yanyan; Liu, Jing; Zhang, Dai; Wang, Lifang

    2016-01-01

    Autism spectrum disorder (ASD) is a group of severe neurodevelopmental disorders. Epigenetic factors play a critical role in the etiology of ASD. Enhancer of zest homolog 2 (EZH2), which encodes a histone methyltransferase, plays an important role in the process of chromatin remodeling during neurodevelopment. Further, EZH2 is located in chromosome 7q35-36, which is one of the linkage regions for autism. However, the genetic relationship between autism and EZH2 remains unclear. To investigate the association between EZH2 and autism in Chinese Han population, we performed a family-based association study between autism and three tagged single nucleotide polymorphisms (SNPs) that covered 95.4% of the whole region of EZH2. In the discovery cohort of 239 trios, two SNPs (rs740949 and rs6464926) showed a significant association with autism. To decrease false positive results, we expanded the sample size to 427 trios. A SNP (rs6464926) was significantly associated with autism even after Bonferroni correction (p=0.008). Haplotype G-T (rs740949 and rs6464926) was a risk factor for autism (Z=2.655, p=0.008, Global p=0.024). In silico function prediction for SNPs indicated that these two SNPs might be regulatory SNPs. Expression pattern of EZH2 showed that it is highly expressed in human embryonic brains. In conclusion, our findings demonstrate that EZH2 might contribute to the genetic etiology of autism in Chinese Han population.

  11. Medicinal use of earths and minerals from Hippocrates to Sir Hans Sloane and beyond.

    Science.gov (United States)

    Retsas, Spyros

    2012-12-01

    In 1931 two pharmaceutical drawers containing mineral specimens, belonging to Sir Hans Sloane, the 18th century collector, Royal Physician, President of the Royal Society and of the Royal College of Physicians of London, were found in the Department of Botany of the Natural History Museum (NHM) of London. The drawers, each divided into 49 compartments, contained a total of 107 mineral pharmaceutical specimens, some labelled as mercury or white arsenic. Their registration, identification with the Sloane Manuscript Catalogues and subsequent transfer to the Mineralogy department of the NHM where one of these drawers is now on public display, had been documented by 1935. In antiquity therapeutic empiricism attributed medicinal properties to animal products, plants and minerals, including the soil of specific geographic locations. This communication traces the medicinal use of certain earths and minerals, listed in Sir Hans Sloane's manuscript catalogues, to classical antiquity with a reference to Arsenic compounds, which in our time are finding application in the treatment of acute promyelocytic leukaemia and to Terra Lemnia, a celebrated antidote of repute spanning twenty centuries, also included in the Sloane collections.

  12. [Hans Gross and the beginning of criminology on a scientific basis].

    Science.gov (United States)

    Bachhiesl, Christian

    2007-01-01

    Modern criminology--if one wants to consider it a separate scientific discipline at all--is usually perceived as being mainly influenced by the methods of natural sciences supplemented by components from the field of psychology, which, at least in some of its conceptions, tends to define itself as a natural science, too. If we take a look at the history of science, we will see development of criminology in this direction was not necessarily inevitable. The scientific work of the Austrian Hans Gross (1847-1915), one of the founding fathers of scientific criminology, serves as an example of the way how natural sciences and their exact methods became established in the methodological apparatus of modern criminology, although in praxi his claim for the application of exact methods was all too often replaced by irrational and intuitive ways of working. Still, Hans Gross' fundamental decision for the exact methods derived from the natural sciences is an important step towards a criminology that can be understood as a part of natural sciences, largely superseding the methods of cultural sciences and anthropological philosophy. This approach made the (criminal) human being an object of measurement and can result in the concept of man as a mere phenomenon of quantity. This is, on the one hand, ethically questionable; on the other hand, it made modern criminology more efficient and successful.

  13. Bronzino and a Bronze Boar. Hans Christian Andersen and Stendhal in Nineteenth-Century Florence

    Directory of Open Access Journals (Sweden)

    Bram de Klerck

    2015-07-01

    Full Text Available Bronzino e il porcellino: Hans Christian Andersen e Stendhal nella Firenze del XIX secoloLa storia dell’arte dell’Ottocento non sembra aver avuto particolarmente a cuore gli artisti italiani delle generazioni successive ai grandi maestri rinascimentali, quali Raffaello e Michelangelo. Così, ad esempio, lo stile delle opere del pittore fiorentino Agnolo Bronzino (1503-1572 veniva giudicato con termini alquanto ostici come ‘vuoto’, ‘offensivo’, o come il risultato di ‘pedanteria anatomica’. Autori con meno preoccupazioni determinate dalla storia dell'arte lasciano tuttavia intravedere di aver apprezzato altre caratteristiche di questi artisti. Almeno gli scritti di un poeta ed un romanziere, ambedue grandi amatori dell’Italia e di firenze, rivelano una valutazione sorprendentemente diversa di un’importante opera del pittore, la sua Discesa di Cristo al Limbo del 1552. Si tratta di Hans Christian Andersen e di Stendhal. Questo contributo alla ricezione dello stile ‘manierista’ del quadro sulla Discesa al Limbo del Bronzino prende in esame sia la critica d’arte del XIX secolo che il modo con cui l’opera è stata trattata dall’immaginazione letteraria, così come risulta dal racconto di Andersen intitolato Il porcellino di bronzo e dal resoconto originale delle esperienze di Stendhal a Firenze, considerate poi come i sintomi della ‘sindrome’ che porta il suo nome.

  14. Association of polymorphisms in the DCDC2 gene with developmental dyslexia in the Han Chinese

    Institute of Scientific and Technical Information of China (English)

    ZUO Peng-xiang; WU Han-rong; LI Zeng-chun; CAO Xu-dong; PANG Li-juan; YANG Lan; LIU Fan; ZHAO Feng

    2012-01-01

    Background Genetic association studies on populations of European origin have identified the DCDC2 gene as a susceptibility locus for developmental dyslexia.Here,we sought to investigate the association of DCDC2 polymorphisms with developmental dyslexia in children of Han Chinese origin.Methods We undertook a case-control genetic association study on 76 dyslexic children and 79 non-dyslexic matched controls.We isolated DNA from oral mucosal cell samples and genotyped two DCDC2 coding-sequence single nucleotide polymorphisms,rs2274305 and rs6456593,in each sample using SNaPshot single nucleotide extension.We compared the allele and genotype frequencies between the groups using the X2 test and analyzed the relationship between dyslexia and the polymorphism at both loci using unconditional logistic regression.We also predicted haplotypes and compared their frequencies between the two groups.Results The differences in the genotype distribution and the allelic genes of the two single nucleotide luci of the DCDC2 gene,rs2274305 and rs6456593,between the two dyslexic and non-dyslexic groups were statistically meaningless (P >0.05).The differences in the haplotype distributions of the DCDC2 gene between the dyslexic and normal group were statistically meaningless (P >0.05).Conclusion The DCDC2 gene may not be a susceptibility factor for developmental dyslexia among the Han Chinese.However,methodological issues may have prevented the detection of oositive associations.

  15. Genetic polymorphisms in ALDH2 are associated with drug addiction in a Chinese Han population.

    Science.gov (United States)

    Zhang, Chan; Ding, Heng; Cheng, Yujing; Chen, Wanlu; Li, Qi; Li, Qing; Dai, Run; Luo, Manlin

    2017-01-31

    We investigated the association between single nucleotide polymorphisms (SNPs) in ALDH2, which has been associated with alcohol dependence and several types of diseases, and the risk of drug addiction in a Chinese Han population. In a case-control study that included 692 cases and 700 healthy controls, eight SNPs in ALDH2 were selected and genotyped using the Sequenom MassARRAY platform. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using unconditional logistic regression after adjusting for age and gender. We determined that rs671 is significantly associated with a 1.551-fold increased drug addiction risk (95% CI = 1.263-1.903; p drug addiction under additive, dominant and recessive models (p drug addiction risk under additive and recessive model, respectively (p drug addiction risk (OR = 1.668; 95% CI, 1.328-2.094, p drug addiction risk (OR = 0.444; 95% CI, 0.281-0.704, p drug addiction in the Chinese Han population.

  16. 汉代的集市贸易%A Study on the Han Dynasty Market Trade

    Institute of Scientific and Technical Information of China (English)

    郭俊然

    2014-01-01

    The Han Dynasty market was a very prosperous integrated market which consisted with va-rious specialized markets ,like horse market ,book market ,wine market ,and so on .These markets were stared spontaneously ,while on the contrary ,the city markets were always under the construction planning with column and square shape .Both of these two were reflected on the prosperous market development of the Han Dynasty .It also reflected the idea of physiocracy about the trade .%汉代集市贸易繁荣,有马市、书市、酒市等专业性的市场。这些集市多自发形成,城市集市则多经人为规划建设。城市集市都是方形,市列纵横。这反映了汉代集市贸易的繁荣和汉代“重农抑商”理念对贸易的阻碍。

  17. Association between Polymorphism of Interleukin-23 Receptor and Hashimoto's Thyroiditis in Chinese Han Population of Shandong

    Institute of Scientific and Technical Information of China (English)

    Zhi-Hua Li; Jie Han; Yu-Fei Wang; Jun Dai; Hui Zhang; Chun-Xia Li; Qun Ma

    2015-01-01

    Objective:The interleukin-23 receptor (IL-23R) has been shown to be associated with autoimmune diseases in many different populations.This study aimed to investigate the association between IL-23R gene polymorphism and susceptibility to Hashimoto's thyroiditis (HT) in Chinese Han population of Shandong.Methods:A case-control cohort study was performed in 145 HT patients from First People's Hospital of Jining between February 2010 to October 2013 and 150 healthy controls.Two single nucleotide polymorphisms located in the promoter region ofIL-23R gene (rs 17375018 and rs7517847) were examined by polymerase chain reaction-restriction fragment length polymorphism analysis.Hardy-Weinberg equilibrium was performed using the Chi-square test.Genotype frequencies were estimated by direct counting,and allele and genotype frequencies between patients and controls were analyzed by the Chi-square test.Results:The rs 17375018 GG genotype and the G allele were significantly increased in HT patients compared with healthy controls (P =0.034 and P =0.013,respectively).No association was identified between HT patients and healthy controls in rs7517847.Conclusion:The study demonstrated that polymorphism of IL-23R gene rs17375018 is highly associated with HT in Chinese Han population of Shandong,suggesting that IL-23R gene polymorphism (rs 17375018 G) may play a critical role in susceptibility to HT.

  18. Age-dependent association of KIBRA gene polymorphism with Alzheimer's disease in Han Chinese.

    Science.gov (United States)

    Wang, Hui-Fu; Tan, Lan; Yu, Jin-Tai; Ma, Xiao-Ying; Liu, Qiu-Yan; Wang, Wei

    2013-12-01

    Genetic factors play an important role in the Alzheimer's disease (AD) development and memory impairment is a cardinal clinical feature of AD. Kidney and brain expressed protein (KIBRA), owing to its connection with human episodic memory, became an interesting candidate gene for AD. Recently, KIBRA (rs17070145) was reported to be associated with AD in the genetic and functional levels in Caucasian and African-American, and the association might be different across age groups. To investigate the possibility of age-dependent association of KIBRA with AD in Asian, we conducted an independent replication study in a cohort of 1,586 subjects from Han Chinese (including 790 LOAD patients and 796 healthy controls). The results revealed no significant differences in the distributions of genotype or allele between LOAD and control groups in the total sample. However, when these data were stratified by their age, we observed a significant difference in the genotypes and alleles frequencies (genotype: p = 0.004, allele: p = 0.035) in the young subgroup. Moreover, the association was further demonstrated in logistic regression analysis (rs17070145: p = 0.045, OR = 0.428). Our data suggested that KIBRA might associate with younger AD patients (≤74 years) in a Northern Han Chinese population.

  19. Histopathological Analysis of Liver During Pregnancy Toxemia in Small-tailed Han Sheep

    Institute of Scientific and Technical Information of China (English)

    Mingcheng WANG; Enzhong LI; Gailing WANG

    2014-01-01

    The present work aimed to investigate the microscopic and ultramicro-scopic structure of the liver to assess the level of hepatic impairment during preg-nancy toxemia. Seven pregnant smal-tailed Han sheep of negative urine ketone bodies were assessed in this study. Toxemia was induced by limiting food and movement late in pregnancy. Three sheep developed obvious clinical symptoms with motor weakness, depression, anorexia, locomotion disturbances, blindness and lan-guishment. We harvested their liver tissues as pathological material, and used rou-tine histological and electronic microscopy methods to observe the histopathological changes in smal-tailed Han sheep induced by pregnancy toxemia. Autopsy of the livers of the sheep revealed deep yel ow coloration, intumescence and hemorrhage on the surface. Microstructural features indicated fatty degeneration, which is a main characteristic of fatty liver. Hepatocel ular ultrastructural changes were observed un-der an electronic microscope. The characteristic findings were nucleolus concentra-tion, vacuolation of mitochondria and excessive glycogen granules in the cytoplasm. Via this experimental protocol, pregnancy toxemia of sheep was successful y in-duced, providing a pathological model for the study of this disease. After the experi-mental induction of pregnancy toxemia, the clinical symptoms of pathogenic sheep and pathological changes to their livers exhibited obvious characteristics of pregnan-cy toxemia.

  20. Genetic polymorphism and evolutionary differentiation of Eastern Chinese Han: a comprehensive and comparative analysis on KIRs

    Science.gov (United States)

    Yin, Caiyong; Hu, Li; Huang, Huijie; Yu, Yanfang; Li, Zheng; Ji, Qiang; Kong, Xiaochao; Wang, Zhongqun; Yan, Jinchuan; Yan, Jiangwei; Zhu, Bofeng; Chen, Feng

    2017-01-01

    Killer cell immunoglobulin-like receptor genes, namely KIRs, cluster together within the 160 kb genomic DNA region. In this study, we used PCR-SSP approach and successfully identified the genotype of 17 KIR genes in 123 independent healthy donors residing in the Jiangsu province, China. All individuals were positive at the 7 genes. The observed carrier gene frequencies (OFs) of remaining 10 KIRs ranged from 14.63% (KIR2DS3) to 95.93% (KIR3DL1). We found 27 distinct genotypes excluding KIR1D. The most frequent occurred in 63 individuals (51.22%). The linkage disequilibrium analysis signified 29 positive and 6 negative relations in 45 pairwise comparisons. To study population differentiation, we drew a Heatmap based on the data of KIRs from 59 populations and conducted Hierarchical Clustering by Euclidean distances. We next validated our results by estimating pairwise DA distances and illustrating a Neighbor-Joining tree, as well as a MDS plot covering 3 additional Chinese Han groups. The phylogenetic reconstruction and cluster analysis strongly indicated a genetically close relationship between Eastern and Jilin Hans. In conclusion, the present study provided a meritorious resource of KIR genotyping for population genetics, and could be helpful to uncover the genetic mechanism of KIRs in immune disease in the future. PMID:28205529

  1. Genetic polymorphism and evolutionary differentiation of Eastern Chinese Han: a comprehensive and comparative analysis on KIRs.

    Science.gov (United States)

    Yin, Caiyong; Hu, Li; Huang, Huijie; Yu, Yanfang; Li, Zheng; Ji, Qiang; Kong, Xiaochao; Wang, Zhongqun; Yan, Jinchuan; Yan, Jiangwei; Zhu, Bofeng; Chen, Feng

    2017-02-16

    Killer cell immunoglobulin-like receptor genes, namely KIRs, cluster together within the 160 kb genomic DNA region. In this study, we used PCR-SSP approach and successfully identified the genotype of 17 KIR genes in 123 independent healthy donors residing in the Jiangsu province, China. All individuals were positive at the 7 genes. The observed carrier gene frequencies (OFs) of remaining 10 KIRs ranged from 14.63% (KIR2DS3) to 95.93% (KIR3DL1). We found 27 distinct genotypes excluding KIR1D. The most frequent occurred in 63 individuals (51.22%). The linkage disequilibrium analysis signified 29 positive and 6 negative relations in 45 pairwise comparisons. To study population differentiation, we drew a Heatmap based on the data of KIRs from 59 populations and conducted Hierarchical Clustering by Euclidean distances. We next validated our results by estimating pairwise DA distances and illustrating a Neighbor-Joining tree, as well as a MDS plot covering 3 additional Chinese Han groups. The phylogenetic reconstruction and cluster analysis strongly indicated a genetically close relationship between Eastern and Jilin Hans. In conclusion, the present study provided a meritorious resource of KIR genotyping for population genetics, and could be helpful to uncover the genetic mechanism of KIRs in immune disease in the future.

  2. RELN gene polymorphisms and susceptibility to autism in Chinese Han population.

    Science.gov (United States)

    Tian, Peichao

    2012-01-01

    Single nucleotide polymorphisms (SNPs) in the Reelin gene (RELN) are likely candidates to confer risk for autism. The objective of the present study is to investigate the association of RELN gene SNPs with autism. A total of 367 Chinese Han subjects were recruited, including 186 autism patients and 181 unrelated healthy controls. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and DNA sequencing methods were used to detect RELN gene polymorphisms. The association between SNPs and autism was analyzed in this study. The g.333509A>C in intron12 and g.504742G>A in exon60 were detected in the RELN gene and a significant association was found between the g.504742G>A polymorphism and autism. Allele and genotype frequencies for the g.504742G>A polymorphism in autistic patients were significantly different for healthy subjects. There was no significantly difference in g.333509A>C polymorphism and autism in the studied populations. Our findings indicated that g.333509A>C was not significantly associated with autism. The g.504742G>A polymorphic variant in the RELN gene might affect subjects susceptibility toward autism in Chinese Han population.

  3. HLA-A gene polymorphisms contribute to osteoporosis susceptibility in postmenopausal Han Chinese women.

    Science.gov (United States)

    Li, S M; Guo, H; Yang, H J; Lv, M Q; Zhou, D X

    2015-08-28

    Osteoporosis is a common disease characterized by low bone mineral density, deterioration in bone microarchitecture, and increased fracture risk and is more prevalent in postmenopausal women. HLA is a complex gene family; previous studies have shown that it plays an important role in the pathogenesis of osteoporosis among Japanese and Greek populations. Prompted by these findings, this study was designed to explore the associations between HLA-A gene polymorphisms and postmenopausal osteoporosis in the Han Chinese population. The polymerase chain reaction-sequence-based typing method was used for DNA genotyping at the HLA-A locus in 70 patients with postmenopausal osteoporosis and 73 healthy controls. We identified 17 HLA-A alleles in patients with postmenopausal osteoporosis and 20 HLA-A alleles in control subjects. Furthermore, we found that the frequency of the HLA-A* 02:07 allele was significantly higher in patients with postmenopausal osteoporosis than in control subjects (P = 0.023), and the relative risk was 4.065 (95% confidence interval = 1.109-14.893). Our study provides supportive evidence for the contribution of HLA-A gene polymorphisms to the susceptibility to postmenopausal osteoporosis and suggests that HLA-A* 02:07 is likely an important genetic risk factor for postmenopausal osteoporosis in the Han Chinese population.

  4. Associations between polymorphisms of HLA-B gene and postmenopausal osteoporosis in Chinese Han population.

    Science.gov (United States)

    Li, S-M; Zhou, D-X; Liu, M-Y

    2014-08-01

    Osteoporosis is a systemic skeletal disease, which is more prevalent in postmenopausal women. Osteoporosis likely develops beginning with genetic risk. This study explored the relationships between polymorphisms of HLA-B gene and postmenopausal osteoporosis in a Chinese Han population. Polymerase chain reaction sequence-based typing (PCR-SBT) method was used for DNA typing at HLA-B locus in 70 patients with postmenopausal osteoporosis and 73 healthy controls in female Han population of Shaanxi Province, situated in north-western China. We found that 40 HLA-B alleles in postmenopausal osteoporosis patients and control subjects, respectively. Furthermore, the frequency of HLA-B* 3501 allele was significantly higher in postmenopausal osteoporosis patients than in the control group (P = 0.033), and the relative risk was 7.632 (95% CI: 0.927-62.850). Our results suggest that HLA-B* 3501 was likely an important risk factor for postmenopausal osteoporosis. As different populations have different HLA polymorphisms, further investigation of the relationship of various HLA genes and osteoporosis with larger sample size is still necessary in the future.

  5. Drought analysis using multi-scale standardized precipitation index in the Han River Basin, China

    Institute of Scientific and Technical Information of China (English)

    Yue-ping XU; Sheng-ji LIN; Yan HUANG; Qin-qing ZHANG; Qi-hua RAN

    2011-01-01

    Regional drought analysis provides useful information for sustainable water resources management. In this paper, a standardized precipitation index (SPI) at multiple time scales was used to investigate the spatial patterns and trends of drought in the Han River Basin, one of the largest tributaries of Yangtze River, China. It was found that, in terms of drought severity, the upper basin of the Hart River is the least, while the growing trend is the most conspicuous; a less conspicuous growing trend can be observed in the middle basin; and there is an insignificant decreasing trend in the lower basin. Meanwhile, the impact of drought on the Middle Route of the South-to-North Water Transfer Project was investigated, and it is suggested that water intake must be reduced in times of drought, particularly when successive or simultaneous droughts in the upper and middle basins of the Han River Basin occur. The results can provide substantial information for future water allocation schemes of the South-to-North Water Transfer Project.

  6. Angiotensin-converting enzyme gene polymorphism and middle cerebral artery stenosis in a Chinese Han population

    Institute of Scientific and Technical Information of China (English)

    Chunshu Rong; Yingqi Xing; Xinmei Jiang; Juan Wang; Baoshan Gao; Jianjun Zhao; Kangding Liu

    2013-01-01

    The angiotensin-converting enzyme gene is a candidate gene of stroke. The present study involved 62 healthy volunteers and 148 patients with middle cerebral artery stenosis as confirmed by brain color ultrasound from a Han population in North China, and determined the peripheral blood angiotensin-converting enzyme genotype using PCR-restriction fragment length polymorphism analysis. The results showed that the frequencies of the DD genotype and D allele were increased in patients with middle cerebral artery stenosis, but the difference was not statistically significant compared with healthy controls. The findings of this study on the relationship between stroke genes and middle cerebral artery stenosis indicate no significant correlation between the frequencies of the DD genotype and D allele of angiotensin-converting enzyme and middle cerebral artery stenosis in this Han population from North China. In the future, studies will be carried out to investigate correlations between multiple stroke candidate gene synergy and middle cerebral artery stenosis to provide a foundation for the development of gene therapy.

  7. Polymorphism Profile of Nine Short Tandem Repeat Loci in the Han Chinese

    Institute of Scientific and Technical Information of China (English)

    Shuangding Li; Chunxia Yan; Yajun Deng; Ruilin Wang; Jian Wang; Huanming Yang; Shengbin Li

    2003-01-01

    Nine short tandem repeat (STR) markers (D3S1358, VWA, FGA, THO1, TPOX,CSFIPO, D5S818, D13S317, and D7S820) and a sex-identification marker (Amel-ogenin locus) were amplified with multiplex PCR and were genotyped with afour-color fluorescence method in samples from 174 unrelated Han individuals inNorth China. The allele frequencies, genotype frequencies, heterozygosity, prob-ability of discrimination powers, probability of paternity exclusion and Hardy-Weinberg equilibrium expectations were determined. The results demonstratedthat the genotypes at all these STR loci in Han population conform to Hardy-Weinberg equilibrium expectations. The combined discrimination power (DP) was1.05 × 10-10 within nine STR loci analyzed and the probability of paternity exclusion(EPP) was 0.9998. The results indicate that these nine STR loci and the Amelo-genin locus are useful markers for human identification, paternity and maternitytesting and sex determination in forensic sciences.

  8. CHRNA5 polymorphisms and risk of lung cancer in Chinese Han smokers

    Science.gov (United States)

    Huang, Chong-Ya; Xun, Xiao-Jie; Wang, A-Jing; Gao, Ya; Ma, Jing-Yuan; Chen, Yuan-Tang; Jin, Tian-Bo; Hou, Peng; Gu, Shan-Zhi

    2015-01-01

    Lung cancer is the most frequent cancer among men in many countries. It is the result of interactions between genetic and environmental factors, among which tobacco smoking is a key environmental factor. CHRNA5, Cholinergic Receptor, Neuronal Nicotinic, Alpha Polypeptide-5, was previously reported to be associated with lung cancer risk. To identify the genetic susceptibility and tobacco smoking that influence lung cancer risk in Han population, we performed a case-control study in 228 patients and 301 controls. These data were compared using the χ2-test, genetic model analysis, and haplotype analysis. rs495956, rs680244, rs601079, rs555018, 588765 and rs11637635 showed an increased risk of lung cancer in both allelic model and genetic mode analysis. The genotype G/A-A/A of rs11637635 was most strongly associated with a 2.17-fold increased risk of lung cancer in dominant model (p = 0.018). One SNP, rs684513, was associated with a 0.645-fold decreased risk (p = 0.033) in allelic model analysis. By haplotype association analysis, haplotype sequences CTTATCAAAGA and GA of CHRNA5 were found to be associated with a 2.03-fold and 1.91-fold increased lung cancer risk (p < 0.05). Our results, combined with those from previous studies, suggest that genetic variation in CHRNA5 may influence susceptibility to lung cancer among Han smokers. PMID:26693074

  9. Vitamin D receptor genetic polymorphisms and tuberculosis among Chinese Han ethnic group

    Institute of Scientific and Technical Information of China (English)

    CAO Shang; LUO Peng-fei; LI Wei; TANG Wan-qin; CONG Xiao-na; WEI Ping-min

    2012-01-01

    Background In epidemiological studies,tuberculosis (TB) appears intimately with vitamin D insufficiency whereas its relationship with vitamin D receptor (VDR) polymorphism caused by radical difference remains unspecified.This study aimed to investigate the relationship between vitamin D genetic polymorphism and tuberculosis in Han ethnic group.Methods Meta-analysis was adopted in the synthetic quantitative analysis of documents home and abroad on the relationship between vitamin D genetic polymorphisms and tuberculosis,which were openly published during June 2000 to January 2010.Random effect model and fixed effect model analyses were used to calculate the incorporated odds ratio (OR) based on the heterogeneity test data.Results A total of 6 eligible studies were included in this analysis.The Fokl-ff genotype showed a significant marginal association (Fixed effect model:OR 1.91,95% CI 1.44-2.52; Random effect model:OR 1.91,95% CI 0.94-3.88),yet Taql polymorphisms was not significantly related to TB.Conclusion The interaction between FoKI genotype polymorphism and TB observed demonstrates that vitamin D deficiency might exist as a risk factor during the development of TB in Han ethnic group and more evidences needed to validate the conclusion.

  10. [Genetic variability and phylogenetic analysis of 39 short tandem repeat loci in Beijing Han population].

    Science.gov (United States)

    Xiuyan, Ruan; Weini, Wang; Yaran, Yang; Bingbing, Xie; Jing, Chen; Yacheng, Liu; Jiangwei, Yan

    2015-07-01

    In this study, we studied the genetic polymorphisms of short tandem repeat (STR) loci from 13 CODIS and 26 non-CODIS system in Beijing Han population for the first time, and established a database of 39 STR loci whose forensic parameters were further evaluated. Our results demonstrated no significant deviation from the Hardy-Weinberg equilibrium of 39 STR loci and no pairwise linkage disequilibrium between them. The power of discriminations, expected heterozygosity, polymorphic information content, and power of exclusion of 39 STR loci ranged from 0.7740-0.9818, 0.6000-0.9350, 0.5317-0.9047 and 0.2909-0.8673. The cumulated discrimination power and cumulative probability of exclusion were 0.999999999999999999999999999999999999999964971 and 0.999999999973878, respectively. Moreover, the genetic distance was calculated based on allele frequency and phylogenetic tree was built using STR loci data from Beijing Han and other 11 Chinese ethnic groups.This study provides important basic data for Chinese forensic DNA database and population genetics database, and has important significance in carrying out forensic individual identification, paternity testing, and population genetic study.

  11. Genetic variations of the ADIPOQgene and risk of prostate cancer in Chinese Han men

    Directory of Open Access Journals (Sweden)

    Cheng-Yuan Gu

    2014-12-01

    Full Text Available Adiponectin secreted by adipose tissue has been implicated in prostate carcinogenesis. Genetic variations in ADIPOQ are thought to influence the activity of adiponectin, thus relating to cancer occurrence. In this hospital-based case-control study of 917 prostate cancer (PCa cases and 1036 cancer-free controls, we evaluated the association of single nucleotide polymorphisms in ADIPOQ with risk of PCa and adiponectin levels in Chinese Han men. Variants of ADIPOQ were genotyped by Taqman polymerase chain reaction method. The plasma adiponectin concentrations were measured by enzyme-linked immunosorbent assay (ELISA in a subset of cases and controls. We found that the ADIPOQ rs3774262 variant AA genotype was associated with both decreased PCa risk [adjusted odds ratio (OR: 0.66, 95% confidence interval (CI =0.48-0.92] and increased plasma adiponectin levels (P = 0.036 and 0.043, with significant difference by tumor grade, clinical stage, and aggressiveness. A significant interaction between ADIPOQ rs3774262 and body mass index was observed in modifying the risk of PCa (P = 6.7 × 10−3 . ADIPOQ rs266729 and rs182052 were not related to PCa risk or plasma adiponectin levels. Our data support that ADIPOQ rs3774262 may affect PCa risk in combination with plasma adiponectin levels in Chinese Han men. It may contribute to the molecular basis for the association between obesity and PCa.

  12. Association of NFATc1 gene polymorphism with ventricular septal defect in the Chinese Han population

    Institute of Scientific and Technical Information of China (English)

    SHEN Lei; LI Zhong-zhi; SHEN A-dong; LIU Hui; BAI Song; GUO Jian; YUAN Feng

    2013-01-01

    Background Congenital heart disease (CHD) is a diverse group of diseases determined by genetic and environmental factors.Considerable research has been done on genes associated with the development of the heart.Recently,focus is on the role of transcription factor NFATc1 in the development of proper valve and septa.As part of a larger study,high density single nucleotide polymorphism (SNP) scanning was used to explore the relationship between NFATc1 gene polymorphism and susceptibility to ventricular septal defect (VSD) in the Chinese Han population.Methods One hundred and ninety-two pediatric patients with congenital VSD and 192 matching healthy control subjects were studied.The haplotype reconstructions were calculated by PHASE2.0 software.Haploview software was used to perform linkage disequilibrium assessment and define haplotype blocks.The algorithm used for defining the blocks was the confidence interval method.Results The NFATc1 gene region can be divided into 11 haplotype blocks.Strong linkage disequilibrium existed within blocks 6,8,9,and 11.Three SNPs (rs7240256,rs11665469,and rs754505) within the NFATc1 gene had significant correlation with VSD by single marker association analysis.In addition,two haplotypes correlated with VSD.Conclusions NFATc1 is associated with the occurrence of VSD and it may be a predisposing gene to CHD in Han Chinese.This finding has set a direction for further genetic and functional studies.

  13. Association between fifteen risk factors and progressing ischemic stroke in the Han population of northeast China

    Institute of Scientific and Technical Information of China (English)

    YANG Shan-shan; TENG Da; YOU Ding-yun; SU Zhi-qiang; LI Fang; ZHAO Ji-yang

    2010-01-01

    Background The mortality and disability associated with progressing ischemic stroke are much higher than general ischemic stroke. This study was conducted to determine the risk factors for progressing ischemic stroke in the Han population of northeast China.Methods A total of 2511 patients with ischemic stroke within 24 hours admitted to Department of Neurology, First Affiliated Hospital of Harbin Medical University were studied, from November 2007 to May 2009. All of the patients were classified into the progressing or non-progressing group according to the scores of the Scandinavian Neurological Stroke Scale. Fifteen putative risk factors were evaluated. The influence of risk factors for progressing ischemic stroke was analyzed with the simple Logistic analysis, the multiple Logistic analysis, and the stepwise Logistic regression model. All the statistical analysis was performed by SAS 9.1.Results Totally 359 (14.3%) patients met the criteria for progressing ischemic stroke. The Logistic analysis showed that age, family stroke history, smoking history, hypertension on admission, a drop in blood pressure after admission to the hospital, high serum glucose on admission, and fever were related to progressing ischemic stroke in the Han population of northeast China.Conclusion People of the ischemic stroke with these factors are more likely to develop progressing ischemic stroke.

  14. Association of a miRNA-137 Polymorphism with Schizophrenia in a Southern Chinese Han Population

    Directory of Open Access Journals (Sweden)

    Guoda Ma

    2014-01-01

    Full Text Available Both genome wide association study (GWAS and biochemical studies of Caucasian populations indicate a robust association between the miR-137 genetic variant rs1625579 and schizophrenia, but inconsistent results have been reported. To assay the association between this variant and schizophrenia, we genotyped 611 schizophrenic patients from Southern Chinese Han population for the risk single nucleotide polymorphism (SNP rs1625579 using the SNaPshot technique and compared the clinical profiles of different genotypes. Additionally, a meta-analysis was performed using the combined sample groups from five case-control publications and the present study. Both the genotype and allele distributions of the rs1625579 SNP were significantly different between patients and controls (P=0.036 and 0.026, SNP. TT genotype carriers showed slightly lower Brief Assessment of Cognition in Schizophrenia- (BACS- derived working memory performance than G carriers (15.58 ± 9.56 versus 19.71 ± 8.18, P=0.045. In the meta-analysis, we observed a significant association between rs1625579 and schizophrenia under different genetic models (all P<0.05. The results of our study and meta-analysis provide convincing evidence that rs1625579 is significantly associated with schizophrenia. Furthermore, the miR-137 polymorphism influences the working memory performance of schizophrenic patients in a Chinese Han population.

  15. Vitamin D receptor genetic polymorphisms and tuberculosis among Chinese Han ethnic group.

    Science.gov (United States)

    Cao, Shang; Luo, Peng-fei; Li, Wei; Tang, Wan-qin; Cong, Xiao-na; Wei, Ping-min

    2012-03-01

    In epidemiological studies, tuberculosis (TB) appears intimately with vitamin D insufficiency whereas its relationship with vitamin D receptor (VDR) polymorphism caused by radical difference remains unspecified. This study aimed to investigate the relationship between vitamin D genetic polymorphism and tuberculosis in Han ethnic group. Meta-analysis was adopted in the synthetic quantitative analysis of documents home and abroad on the relationship between vitamin D genetic polymorphisms and tuberculosis, which were openly published during June 2000 to January 2010. Random effect model and fixed effect model analyses were used to calculate the incorporated odds ratio (OR) based on the heterogeneity test data. A total of 6 eligible studies were included in this analysis. The FokI-ff genotype showed a significant marginal association (Fixed effect model: OR 1.91, 95%CI 1.44-2.52; Random effect model: OR 1.91, 95%CI 0.94-3.88), yet TaqI polymorphisms was not significantly related to TB. The interaction between FoKI genotype polymorphism and TB observed demonstrates that vitamin D deficiency might exist as a risk factor during the development of TB in Han ethnic group and more evidences needed to validate the conclusion.

  16. The Life and Works of Han Shin Gwang : a Midwife and Nurse of Korean Modern Times

    Directory of Open Access Journals (Sweden)

    YI Ggodme

    2006-06-01

    Full Text Available Han Shin Gwang, born in an early Christian family in Korea in 1902, could get western education different from the ordinary Korean girls in that period. She participated in the 1919 Samil Independence Movement in her teens, and got nursing and midwifery education in a missionary hospital. She got a midwife license and worked as a member in an early mother-and-child health center. She organized 'Korean Nurses' Association' in 1924 and focused on public health movement as the chairwoman. She actively participated in women's movement organizations, and Gwangjoo Student's Movement. She was known to be a representative of leading working women, and wrote articles on woman's right, the needs and works of nurses and midwives. From late Japanese colonial period, she opened her own clinic and devoted herself to midwifery. After the Korean Liberation in 1945, she began political movement and went in for a senate election. During the Korean War, she founded a shelter for mothers and children in help. After the War, she reopened a midwifery clinic and devoted to the works of Korean Midwives' Association. Han Shin Gwang's life and works belong to the first generation of Korean working women in modern times. She actively participated in women's movement, nurses' and midwives professional movement, Korea liberation movement, and mother-and-child health movement for 60 years. Her life is truly exemplary as one of the first generation of working women in modern Korea, distinguished of devotion and calling.

  17. White blood cells contribute to patient-specific warfarin dose for Han Chinese

    Institute of Scientific and Technical Information of China (English)

    ZHU Jin; ZHENG Wen-jie; ZHANG Wei-juan; WANG He-yao; WANG Chen

    2012-01-01

    Background Warfarin is the most commonly prescribed anticoagulant worldwide.Factors which influence warfarin's inter-individual requirements including age,weight,and genetic factors explained about 50% of dose variance,and unidentified factors still remain.The aim of this study was to explore whether white blood cell count affects warfarin dose requirements.Methods Three hundred and twenty-two patients suffering from venous thromboembolism (VTE) and taking warfarin were recruited in this study.Genotyping of selected genes was conducted and other information was collected using the Epidata software.Dosing algorithms were constructed by multivariate linear regression analyses.Results In addition to well-known factors such as age,body weight,CYP2Cg*3,and VKORC1 c.1173C>T,white blood cell counts negatively related to warfarin dose requirements and contributed to warfarin variability in Han Chinese by about 0.6%.Conclusion White blood cell count has a small but significant contribution to warfarin dose requirements in Han Chinese.

  18. Hans Georg Trüper (1936–2016) and His Contributions to Halophile Research

    Science.gov (United States)

    Oren, Aharon

    2016-01-01

    Prof. Hans Georg Trüper, one of the most important scientists in the field of halophile research, passed away on 9 March 2016 at the age of 79. I here present a brief obituary with special emphasis on Prof. Trüper’s contributions to our understanding of the halophilic prokaryotes and their adaptations to life in hypersaline environments. He has pioneered the study of the halophilic anoxygenic phototrophic sulfur bacteria of the Ectothiorhodospira—Halorhodospira group. Some of the species he and his group isolated from hypersaline and haloalkaline environments have become model organisms for the study of the mechanisms of haloadaptation: the functions of three major organic compounds – glycine betaine, ectoine, and trehalose – known to serve as “compatible solutes” in halophilic members of the Bacteria domain, were discovered during studies of these anoxygenic phototrophs. Prof. Trüper’s studies of hypersaline alkaline environments in Egypt also led to the isolation of the first known extremely halophilic archaeon (Natronomonas pharaonis). The guest editors dedicate this special volume of Life to the memory of Prof. Hans Georg Trüper. PMID:27187481

  19. Relationship between genetic polymorphisms in the DRD5 gene and paranoid schizophrenia in northern Han Chinese.

    Science.gov (United States)

    Zhao, Y; Ding, M; Pang, H; Xu, X M; Wang, B J

    2014-03-12

    Dopamine (DA) has been implicated in the pathophysiol-ogy of several psychiatric disorders, including schizophrenia. Thus, genes related to the dopaminergic (DAergic) system are good candidate genes for schizophrenia. One of receptors of the DA receptor system is dopa-mine receptor 5 (DRD5). Single nucleotide polymorphisms (SNPs) in the regulatory regions of DRD5 gene may affect gene expression, influence biosynthesis of DA and underlie various neuropsychiatric disorders re-lated to DA dysfunction. The present study explored the association of SNPs within the DRD5 gene with paranoid schizophrenia in Han Chinese. A total of 176 patients with schizophrenia and 206 healthy controls were genotyped for four DRD5 SNPs (rs77434921, rs2076907, rs6283, and rs1800762). Significant group differences were observed in the allele and genotype frequencies of rs77434921 and rs1800762 and in the frequen-cies of GC haplotypes corresponding to rs77434921-rs1800762. Our find-ings suggest that common genetic variations of DRD5 are likely to con-tribute to genetic susceptibility to paranoid schizophrenia in Han Chinese. Further studies in larger samples are needed to replicate this association.

  20. Dr. Hans Max Hirschfeld, man zonder moreel kompas? Over de ontsporing van beeldvorming

    Directory of Open Access Journals (Sweden)

    R. de Bruin

    2008-01-01

    Full Text Available Dr Hans Max Hirschfeld: A Man without a Moral Compass? On Dislodging PerceptionsEven though his father was Jewish, Hans Max Hirschfeld became one of the most prominent Dutch civil servants during the German Occupation of the Netherlands. In the interest of the Dutch population, Hirschfeld was supposed to co-operate with the German Reichskommissariat. However, various measures made him very unpopular with the government in exile and the resistance movement. In his well-read history of the Netherlands under Nazi rule, Dutch historian Loe de Jong portrayed Hirschfeld as the personification of the aloofness that was characteristic of many Dutch people with regard to the persecution of the Jews. De Jong characterized Hirschfeld as a typical ‘negotiator’, who had learned to shield his emotions regarding the fate of the Jews. In the past few years, two biographies on Hirschfeld have been published, in which De Jong’s characterizations play a major role. This article, based on research of De Jong’s records, claims that the characterizations were largely inventions of De Jong, rooted in images projected in the illegal press during the German Occupation.

  1. Polymorphism of the catechol-O-methyltransferase gene in Han Chinese patients with psoriasis vulgaris

    Directory of Open Access Journals (Sweden)

    Lin Gao

    2009-01-01

    Full Text Available Psoriasis vulgaris is defined by a series of linked cellular changes in the skin: hyperplasia of epidermal keratinocytes, vascular hyperplasia and ectasia, and infiltration of T lymphocytes, neutrophils and other types of leukocytes in the affected skin. Catechol-O-methyltransferase ( COMT 158 polymorphism can reduce the activity of the COMT enzyme that may trigger defective differentiation of keratinocytes in psoriasis. Immunocytes can degrade and inactivate catecholamines via monamine oxidase (MAO and COMT in the cells. We hypothesized that the COMT-158 G > A polymorphism was associated with the risk of psoriasis vulgaris in Han Chinese people. In a hospital-based case-control study, 524 patients with psoriasis vulgaris and 549 psoriasis-free controls were studied. COMT-158 G > A polymorphism was genotyped using the PCR sequence-specific primer (PCR-SSP technique. We found no statistically significant association between the COMT-158 allele A and the risk of psoriasis vulgaris (p = 0.739 adjusted OR = 1.03; 95% CI = 0.81-1.31. This suggests that the COMT-158 G > A polymorphism may not contribute to the etiology of psoriasis vulgaris in the Han Chinese population.

  2. Genetic association between NRG1 and schizophrenia, major depressive disorder, bipolar disorder in Han Chinese population.

    Science.gov (United States)

    Wen, Zujia; Chen, Jianhua; Khan, Raja Amjad Waheed; Song, Zhijian; Wang, Meng; Li, Zhiqiang; Shen, Jiawei; Li, Wenjin; Shi, Yongyong

    2016-04-01

    Schizophrenia, major depressive disorder, and bipolar disorder are three major psychiatric disorders affecting around 0.66%, 3.3%, and 1.5% of the Han Chinese population respectively. Several genetic linkage analyses and genome wide association studies identified NRG1 as a susceptibility gene of schizophrenia, which was validated by its role in neurodevelopment, glutamate, and other neurotransmitter receptor expression regulation. To further investigate whether NRG1 is a shared risk gene for major depressive disorder, bipolar disorder as well as schizophrenia, we performed an association study among 1,248 schizophrenia cases, 1,056 major depression cases, 1,344 bipolar disorder cases, and 1,248 controls. Totally 15 tag SNPs were genotyped and analyzed, and no population stratification was found in our sample set. Among the sites, rs4236710 (corrected Pgenotye  = 0.015) and rs4512342 (Pallele  = 0.03, Pgenotye  = 0.045 after correction) were associated with schizophrenia, and rs2919375 (corrected Pgenotye  = 0.004) was associated with major depressive disorder. The haplotype rs4512342-rs6982890 showed association with schizophrenia (P = 0.03 for haplotype "TC" after correction), and haplotype rs4531002-rs11989919 proved to be a shared risk factor for both major depressive disorder ("CC": corrected P = 0.009) and bipolar disorder ("CT": corrected P = 0.003). Our results confirmed that NRG1 was a shared common susceptibility gene for major mental disorders in Han Chinese population.

  3. Correlation between IL-6 gene polymorphisms and sepsis of Chinese Han population in Henan province

    Directory of Open Access Journals (Sweden)

    Meng-xuan YANG

    2011-01-01

    Full Text Available Objective To investigate the correlation between-572G/C and-174G/C polymorphism of IL-6 gene and sepsis of Chinese Han population in Henan province.Methods A population-based case-control study involving 99 patients with sepsis and 260 health volunteers(control was carried out.The-572C/G and-174G/C polymorphism of IL-6 gene was analyzed by polymerase chain reaction and restriction fragment-length polymorphism(PCR-RFLP technique.Results The genotype frequencies of all 359 cases were in Hardy-Weinberg equilibrium(P>0.05.No polymorphism was found in-174 site(GG genotype only,while alleles G,C and genotypes GG,GC,CC were found in-572 site,and no significant difference of allele frequency existed between patients and controls.Unconditional logistic regression analysis showed-G572C polymorphism was related to sepsis,the susceptibility to sepsis of patients with GG genotype was significantly higher than that of patients with CC genotype(OR=2.411,95% CI=1.045-5.562,P=0.039 after age and gender correction.Conclusions The-G572C polymorphism of IL-6 gene associates with sepsis,and the GG is the risk genotype of sepsis.There maybe no polymorphism in-G174C of IL-6 gene of Chinese Han population in Henan province.

  4. Association of the LRRK2 genetic polymorphisms with leprosy in Han Chinese from Southwest China.

    Science.gov (United States)

    Wang, D; Xu, L; Lv, L; Su, L-Y; Fan, Y; Zhang, D-F; Bi, R; Yu, D; Zhang, W; Li, X-A; Li, Y-Y; Yao, Y-G

    2015-03-01

    Leprosy is a chronic infectious and neurological disease that is caused by infection of Mycobacterium leprae (M. leprae). A recent genome-wide association study indicated a suggestive association of LRRK2 genetic variant rs1873613 with leprosy in Chinese population. To validate this association and further identify potential causal variants of LRRK2 with leprosy, we genotyped 13 LRRK2 variants in 548 leprosy patients and 1078 healthy individuals from Yunnan Province and (re-)analyzed 3225 Han Chinese across China. Variants rs1427267, rs3761863, rs1873613, rs732374 and rs7298930 were significantly associated with leprosy per se and/or paucibacillary leprosy (PB). Haplotype A-G-A-C-A was significantly associated with leprosy per se (P=0.018) and PB (P=0.020). Overexpression of the protective allele (Thr2397) of rs3761863 in HEK293 cells led to a significantly increased nuclear factor of activated T-cells' activity compared with allele Met2397 after lipopolysaccharides stimulation. Allele Thr2397 could attenuate 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-induced autophagic activity in U251 cells. These data suggest that the protective effect of LRRK2 variant p.M2397T on leprosy might be mediated by increasing immune response and decreasing neurotoxicity after M. leprae loading. Our findings confirm that LRRK2 is a susceptible gene to leprosy in Han Chinese population.

  5. Impact of strabismus on the quality of life of Chinese Han teenagers

    Directory of Open Access Journals (Sweden)

    Tu CS

    2016-06-01

    Full Text Available Changsen Tu, Liang Ye, Longfei Jiang, Yuwen Wang, Yingzi Li The Eye Hospital of Wenzhou Medical University, School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, People’s Republic of China Background: Although much research has been conducted on the impact of strabismus on the quality of life (QoL of adults, the effect of this condition on teenagers has not been extensively studied. This study therefore aimed to assess the effect of strabismus on the vision-related QoL of Chinese teenagers.Methods: The Chinese version of the 25-item National Eye Institute Visual Function Questionnaire (NEI-VFQ-25 was self-administered by 1,040 teenagers with strabismus and 1,002 individuals with normal vision. All the participants were from the Chinese Han population. The independent samples t-test was used to compare QoL between teenagers with and without strabismus.Results: The majority of scores on the NEI-VFQ-25 domains were significantly different between the two groups. QoL was significantly lower in individuals with strabismus compared with teenagers with normal vision on all domains, with the exception of social functioning.Conclusion: Statistically significantly lower vision-related QoL scores were found in Chinese Han teenagers with strabismus compared with those without strabismus. Keywords: quality of life, strabismus, NEI-VFQ-25, teenager, HRQoL

  6. Hans Ballmer : la poesía y el movimiento de la aniquilación

    Directory of Open Access Journals (Sweden)

    Constanza Nieto Yusta

    2006-01-01

    Full Text Available En la producción artística de Hans Bellmer confluyen factores que se inscriben tanto en el ámbito de la creación artística como en el mundo especulativo. Es en este sentido cómo pueden entenderse sus famosas poupées, objetos poéticos y científicos a través de los cuales es posible desgranar aquellos temas que obsesionaron al artista desde su más temprana juventud y que engloban desde los temores inocentes y los juegos de la primera infancia hasta la posterior exploración de la aniquilación a través del veneno, la sexualidad y el movimiento.The artistic production of the surrealist Hans Bellmer shows the importance of two elements, opposed in appearance: Poetry and Science. Is in this sense how his lifesize dolls can be considered, as poetic and scientific objects where it is possible to find the subjects that turned into obsessions since his most early childhood: games, science mechanisms, poison, sexuality, movement and death.

  7. Hans Georg Trüper (1936–2016 and His Contributions to Halophile Research

    Directory of Open Access Journals (Sweden)

    Aharon Oren

    2016-05-01

    Full Text Available Prof. Hans Georg Trüper, one of the most important scientists in the field of halophile research, passed away on 9 March 2016 at the age of 79. I here present a brief obituary with special emphasis on Prof. Trüper’s contributions to our understanding of the halophilic prokaryotes and their adaptations to life in hypersaline environments. He has pioneered the study of the halophilic anoxygenic phototrophic sulfur bacteria of the Ectothiorhodospira—Halorhodospira group. Some of the species he and his group isolated from hypersaline and haloalkaline environments have become model organisms for the study of the mechanisms of haloadaptation: the functions of three major organic compounds – glycine betaine, ectoine, and trehalose – known to serve as “compatible solutes” in halophilic members of the Bacteria domain, were discovered during studies of these anoxygenic phototrophs. Prof. Trüper’s studies of hypersaline alkaline environments in Egypt also led to the isolation of the first known extremely halophilic archaeon (Natronomonas pharaonis. The guest editors dedicate this special volume of Life to the memory of Prof. Hans Georg Trüper.

  8. Applicability of the Tanaka-Johnston and Moyers mixed dentition analyses in Northeast Han Chinese.

    Science.gov (United States)

    Sherpa, Jangbu; Sah, Gopal; Rong, Zeng; Wu, Lipeng

    2015-06-01

    To assess applicability of the Tanaka-Johnston and Moyers prediction methods in a Han ethnic group from Northeast China and to develop prediction equations for this same population. Cross-sectional study. Department of Orthodontics, School of Stomatology, Jiamusi University, Heilongjiang, China. A total of 130 subjects (65 male and 65 female) aged 16-21 years from a Han ethnic group of Northeast China were recruited from dental students and patients seeking orthodontic treatment. Ethnicity was verified by questionnaire. Mesio-distal tooth width was measured using Digital Vernier calipers. Predicted values were obtained from the Tanaka-Johnston and Moyers methods in both arches were compared with the actual measured widths. Based on regression analysis, prediction equations were developed. Tanaka-Johnston equations were not precise, except for the upper arch in males. However, the Moyers 85th percentile in the upper arch and 75th percentile in the lower arch predicted the sum precisely in males. For females, the Moyers 75th percentile predicted the sum precisely for the upper arch, but none of the Moyers percentiles predicted in the lower arch. Both the Tanaka-Johnston and Moyers method may not be applied universally without question. Hence, it may be safer to develop regression equations for specific populations. Validating studies must be conducted to confirm the precision of these newly developed regression equations.

  9. 50 Years of Bong-Han Theory and 10 Years of Primo Vascular System

    Directory of Open Access Journals (Sweden)

    Kwang-Sup Soh

    2013-01-01

    Full Text Available The primo vascular system (PVS was first introduced by Bong-Han Kim via his five research reports. Among these the third report was most extensive and conclusive in terms of the PVS anatomy and physiology relating to the acupuncture meridians. His study results, unfortunately, were not reproduced by other scientists because he did not describe the materials and methods in detail. In 2002, a research team in Seoul National University reinitiated the PVS research, confirmed the existence of PVS in various organs, and discovered new characteristics of PVS. Two important examples are as follows: PVS was found in the adipose tissue and around cancer tissues. In parallel to these new findings, new methods for observing and identifying PVS were developed. Studies on the cell and material content inside the PVS, including the immune function cells and stem cells, are being progressed. In this review, Bong-Han Kim’s study results in his third report are summarized, and the new results after him are briefly reviewed. In the last section, the obstacles in finding the PVS in the skin as an anatomical structure of acupuncture meridian are discussed.

  10. 50 years of bong-han theory and 10 years of primo vascular system.

    Science.gov (United States)

    Soh, Kwang-Sup; Kang, Kyung A; Ryu, Yeon Hee

    2013-01-01

    The primo vascular system (PVS) was first introduced by Bong-Han Kim via his five research reports. Among these the third report was most extensive and conclusive in terms of the PVS anatomy and physiology relating to the acupuncture meridians. His study results, unfortunately, were not reproduced by other scientists because he did not describe the materials and methods in detail. In 2002, a research team in Seoul National University reinitiated the PVS research, confirmed the existence of PVS in various organs, and discovered new characteristics of PVS. Two important examples are as follows: PVS was found in the adipose tissue and around cancer tissues. In parallel to these new findings, new methods for observing and identifying PVS were developed. Studies on the cell and material content inside the PVS, including the immune function cells and stem cells, are being progressed. In this review, Bong-Han Kim's study results in his third report are summarized, and the new results after him are briefly reviewed. In the last section, the obstacles in finding the PVS in the skin as an anatomical structure of acupuncture meridian are discussed.

  11. 韩氏穴位神经刺激仪对妊娠晚期下腰痛的影响%THE EFFECT OF HANS ACUPOINT NERVE TIMULATOR ( HANS ) ON THE LOW BACK PAIN IN LATE PREGNANCY

    Institute of Scientific and Technical Information of China (English)

    陈伟业; 王爱群; 张立贤

    2011-01-01

    目的:评估韩氏穴位神经刺激仪(HANS)对妊娠晚期下腰痛的疗效及安全性.方法:95例妊娠晚期下腰痛孕妇随机分入HANS组(n=46)和对照组(n=49).HANS组给予每周一次的HANS治疗,持续6周;对照组未予治疗.采用视觉模拟评分(VAS)评估孕妇下腰痛程度.记录HANS治疗即时反应、孕妇早产率、新生儿情况和分娩方式.结果:对照组孕妇下腰痛有加重趋势.HANS组孕妇下腰痛程度比治疗前好转,较对照组也显著减轻(P<0.05),未发现严重不良反应.两组孕妇早产率、新生儿情况、分娩方式差异无显著性意义(P>0.05).结论:HANS可安全用于孕妇并减轻妊娠晚期下腰痛.%Objective: To evaluate the analgesic effect and safety of HANS for low back pain during the third trimester of pregnancy. Methods: 95 women in late pregnancy with low back pain were randomized into HANS group (n = 46) and control group (n = 49). HANS group has HANS treatment once a week for 6 weeks and control group without treatment. Self-reported pain intensity was assessed on a visual analog scale (VAS). Immediate events of HANS treatment, incidence of preterm delivery, neonatal outcome and mode of delivery were also recorded. Results: The intensity after low back pain in control group increased as pregnancy advanced. HANS group showed reduction in the intensity of low back pain after treatment, and were less than that in control group (P < 0.05). No serious adverse effects were found in HANS group. There was no difference on data of the neonatal outcome, incidence of preterm delivery and mode of delivery between the two groups. Conclusion: HANS can be safely used and reduced the intensity of low back pain in late pregnancy.

  12. ITIH family genes confer risk to schizophrenia and major depressive disorder in the Han Chinese population.

    Science.gov (United States)

    He, Kuanjun; Wang, Qingzhong; Chen, Jianhua; Li, Tao; Li, Zhiqiang; Li, Wenjin; Wen, Zujia; Qiang, Yu; Wang, Meng; Shen, Jiawei; Song, Zhijian; Ji, Jue; Feng, Guoyin; Qi, Shuguang; Lin, He; Shi, Yongyong; Cheng, Zaohuo

    2014-06-03

    As a major extracellular matrix component, ITIHs played an important role in inflammation and carcinogenesis. Several genome-wide association studies have reported that some positive signals which were derived from the tight linkage disequilibrium region on chromosome 3p21 were associated with both schizophrenia and bipolar disorders in the Caucasian population. To further investigate whether this genomic region is also a susceptibility locus of schizophrenia and major depressive disorder in the Han Chinese population, we conducted this study by recruiting 1235 schizophrenia patients, 1045 major depressive disorder patients and 1235 healthy control subjects in the Han Chinese samples for a case-control study. We genotyped seven SNPs within this region using TaqMan® technology. We found that rs2710322 was significantly associated with schizophrenia (adjusted P(allele) = 0.0018, adjusted P(genotype) = 0.006, OR [95% CI] = 1.278 [1.117-1.462]) while rs1042779 was weakly associated with schizophrenia (adjusted P(allele) = 0.048, OR [95% CI] = 1.164 [1.040-1.303]) and major depressive disorder (adjusted P(allele) = 0.042, OR [95% CI] = 1.178 [1.047-1.326]); it was also our finding that rs3821831 was positively associated with major depressive disorder (adjusted P(allele) = 0.003, adjusted P(genotype) = 0.006, OR [95% CI] = 1.426 [1.156-1.760]). Furthermore, no haplotype was found to be associated with schizophrenia and major depressive disorder. Via the association analysis which combines the schizophrenia and major depressive disorder cases, we also notice that rs1042779 and rs3821831 were significantly associated with combined cases (rs1042779: adjusted P(allele) = 0.012, adjusted P(genotype) = 0.018, OR [95% CI] = 1.171 [1.060-1.292]; rs3821831:adjusted P(genotype) = 0.012, OR [95% CI] = 1.193 [1.010-1.410]). Our results revealed that the shared genetic risk factors of both schizophrenia and major depressive disorder exist in ITIH family genes in the Han Chinese

  13. Carta abierta a Hans Christian Andersen en el bicentenario de su nacimiento

    Directory of Open Access Journals (Sweden)

    Carlos Alberto Rubio Torres

    2005-06-01

    Full Text Available

    Resumen. El 2 de abril del 2005 se realizó una doble celebración: el bicentenario del natalicio del escritor danés Hans Christian Andersen y el Día Internacional del Libro Infantil. Se considera a este autor como el creador de la literatura para niños contemporánea, por introducir discursos reservados, hasta aquel momento, exclusivamente para adultos.

    La “Carta abierta” fue leída a estudiantes de la Universidad Centroamericana (UCA en Managua, Nicaragua, en el marco del Festival dedicado a Andersen, organizado por la Fundación Libros para Niños con el apoyo de las embajadas de Noruega y Dinamarca. En ella, se trata de establecer un perfil biográfico de Andersen y se exploran posibles lecturas de sus cuentos, desde perspectivas educativas, psicológicas y psicoanalíticas. Concluye con una interpretación de Andersen como metáfora del entendimiento y el diálogo entre Costa Rica y Nicaragua.

    Asimismo, este trabajo es la base para el suplemento Educare en el aula, el cual contiene ideas para la motivación a la lectura. Como complemento, se adiciona el cuento El porquerizo de Hans Christian Andersen.

     

    Abstract. April 2nd, 2005 was a day for a double celebration: the bicentennial of the birth of Danish writer Hans Christian Andersen and the International Children’s Book Day. Andersen is known as the creator of contemporary children literature, for his fairy tales introduce language that at that time was used by adults only.

    Students from Central American University (UCA in Managua, Nicaragua, read an “Open Letter” during a Festival that the Books for Children Foundation organized in honor of the author along with the Norwegian and Danish embassies. The letter presents Andersen’s biography and explores alternative readings of his fairy tales from educational, psychological and psychoanalytical perspectives. The letter concludes

  14. Modernidad y humanismo civil: debates y perspectivas en torno a la tesis de Hans Baron

    Directory of Open Access Journals (Sweden)

    Sverlij, Mariana

    2013-12-01

    Full Text Available Resumen En 1952, Hans Baron concluye su obra más importante: The Crisis of the early Italian Renaissance, publicada por la Universidad de Princeton en dos volúmenes, en 1955. En ella, Baron desarrolla el concepto de “humanismo civil”, desde el cual analiza el humanismo florentino del siglo XV y, en particular, la obra de Leonardo Bruni. Para Baron, los humanistas florentinos, en su lucha por la libertad de Florencia ante la amenaza de la Milán de los Visconti, articularon una novedosa relación entre intelectualidad y política. Este movimiento intelectual, al mismo tiempo, abrió las puertas al pensamiento moderno. Numerosas críticas recibió, desde entonces, el trabajo de Baron, centralmente, por parte de aquellos que reivindicaron las continuidades entre la Edad Media y el Renacimiento, así como también por parte de los que han leído críticamente el éxito que tuvo la Crisis en las academias norteamericanas y su influencia en la consolidación de la “ideología americana”. El artículo propone una revisión de la tesis de Baron así como de las controversias generadas en torno a ella, para, finalmente, esbozar la posibilidad de revisar el concepto de “humanismo civil” desde la obra de Leon Battista Alberti. Abstract In 1952, Hans Baron finished his most important work, The Crisis of the Early Italian Renaissance, published in two volumes by Princeton University in 1955. In this work, the author expounds on the concept of “civil humanism” which he uses to analyze the Florentine humanism of the fifteenth century, and in particular, Leonardo Bruni’s work. According to Baron, Florentine humanists, fighting for Florence’s freedom against the threat of Visconti’s Milan, developed a novel relationship between intellectualism and politics. This intellectual movement also paved the way for modern thought. Baron’s work has been critically reviewed many times since then, especially, by those who vindicated the

  15. Molecular basis of weak D and DEL in Han population in Anhui Province, China

    Institute of Scientific and Technical Information of China (English)

    CHEN Qing; LI Ming; LI Min; LU Xue-song; L(U) Rong; SUN Jun; LIU Zhong

    2012-01-01

    Background Rh blood group system is the most complex and immunogenetic blood group system.Prevalent RHD alleles varied in different populations.The purpose of this study is to determine the molecular basis of weak D and DEL phenotype in Anhui Chinese Han population.Methods The D antigen was determined with IgM monoclonal anti-D conformed to the guidelines for donor testing in China.Weak D samples were identified by an indirect antiglobulin test.DEL phenotype was determined by adsorption and elution test.All the RHD 10 exons were screened by PCR with sequence-specific priming or sequenced for the first-time donors who typed weak D,DEL or D negative by serologic test.Results Of all the 30 799 blood donors,155 blood samples were found D negative with IgM anti-D; 34 blood samples were found D positive by indirect antiglobulin test or absorption elution test.RHD alleles were identified by nucleotide sequencing.Total 4 RHD alleles were found including two new.One hundred and twenty of 155 (77.4%) of the serologically D negative samples lacked the RHD gene.One D negative was RHD(615de12).Thirty-two of 155 (20.6%)carried RHD(K409K) among them one carrying 1227G>A and 845G>A.Two of 155 (1.3%) was weak D type 15.Conclusions In this study at the molecular level,all DEL phenotype is RHD(K40gK); weak D type 15 is the prevalent weak D allele in Anhui Chinese Han population.Additionally,an improved more efficient method was adopted to amplify all the RHD exons in one PCR program.Our study added to the understanding of molecular mechanisms underlying D antigen expression in Anhui Han population and provided useful information for adopting suitable genotyping strategies in routine use.

  16. BFH-OST, a new predictive screening tool for identifying osteoporosis in postmenopausal Han Chinese women

    Directory of Open Access Journals (Sweden)

    Ma Z

    2016-08-01

    Full Text Available Zhao Ma, Yong Yang,* JiSheng Lin, XiaoDong Zhang, Qian Meng, BingQiang Wang, Qi Fei* Department of Orthopedics, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of China *These authors contributed equally to this work Purpose: To develop a simple new clinical screening tool to identify primary osteoporosis by dual-energy X-ray absorptiometry (DXA in postmenopausal women and to compare its validity with the Osteoporosis Self-Assessment Tool for Asians (OSTA in a Han Chinese population.Methods: A cross-sectional study was conducted, enrolling 1,721 community-dwelling postmenopausal Han Chinese women. All the subjects completed a structured questionnaire and had their bone mineral density measured using DXA. Using logistic regression analysis, we assessed the ability of numerous potential risk factors examined in the questionnaire to identify women with osteoporosis. Based on this analysis, we build a new predictive model, the Beijing Friendship Hospital Osteoporosis Self-Assessment Tool (BFH-OST. Receiver operating characteristic curves were generated to compare the validity of the new model and OSTA in identifying postmenopausal women at increased risk of primary osteoporosis as defined according to the World Health Organization criteria.Results: At screening, it was found that of the 1,721 subjects with DXA, 22.66% had osteoporosis and a further 47.36% had osteopenia. Of the items screened in the questionnaire, it was found that age, weight, height, body mass index, personal history of fracture after the age of 45 years, history of fragility fracture in either parent, current smoking, and consumption of three of more alcoholic drinks per day were all predictive of osteoporosis. However, age at menarche and menopause, years since menopause, and number of pregnancies and live births were irrelevant in this study. The logistic regression analysis and item reduction yielded a final tool (BFH-OST based on age

  17. BFH-OST, a new predictive screening tool for identifying osteoporosis in postmenopausal Han Chinese women

    Science.gov (United States)

    Ma, Zhao; Yang, Yong; Lin, JiSheng; Zhang, XiaoDong; Meng, Qian; Wang, BingQiang; Fei, Qi

    2016-01-01

    Purpose To develop a simple new clinical screening tool to identify primary osteoporosis by dual-energy X-ray absorptiometry (DXA) in postmenopausal women and to compare its validity with the Osteoporosis Self-Assessment Tool for Asians (OSTA) in a Han Chinese population. Methods A cross-sectional study was conducted, enrolling 1,721 community-dwelling postmenopausal Han Chinese women. All the subjects completed a structured questionnaire and had their bone mineral density measured using DXA. Using logistic regression analysis, we assessed the ability of numerous potential risk factors examined in the questionnaire to identify women with osteoporosis. Based on this analysis, we build a new predictive model, the Beijing Friendship Hospital Osteoporosis Self-Assessment Tool (BFH-OST). Receiver operating characteristic curves were generated to compare the validity of the new model and OSTA in identifying postmenopausal women at increased risk of primary osteoporosis as defined according to the World Health Organization criteria. Results At screening, it was found that of the 1,721 subjects with DXA, 22.66% had osteoporosis and a further 47.36% had osteopenia. Of the items screened in the questionnaire, it was found that age, weight, height, body mass index, personal history of fracture after the age of 45 years, history of fragility fracture in either parent, current smoking, and consumption of three of more alcoholic drinks per day were all predictive of osteoporosis. However, age at menarche and menopause, years since menopause, and number of pregnancies and live births were irrelevant in this study. The logistic regression analysis and item reduction yielded a final tool (BFH-OST) based on age, body weight, height, and history of fracture after the age of 45 years. The BFH-OST index (cutoff =9.1), which performed better than OSTA, had a sensitivity of 73.6% and a specificity of 72.7% for identifying osteoporosis, with an area under the receiver operating

  18. Prediction consistency and clinical presentations of breast cancer molecular subtypes for Han Chinese population

    Directory of Open Access Journals (Sweden)

    Huang Chi-Cheng

    2012-09-01

    Full Text Available Abstract Background Breast cancer is a heterogeneous disease in terms of transcriptional aberrations; moreover, microarray gene expression profiles had defined 5 molecular subtypes based on certain intrinsic genes. This study aimed to evaluate the prediction consistency of breast cancer molecular subtypes from 3 distinct intrinsic gene sets (Sørlie 500, Hu 306 and PAM50 as well as clinical presentations of each molecualr subtype in Han Chinese population. Methods In all, 169 breast cancer samples (44 from Taiwan and 125 from China of Han Chinese population were gathered, and the gene expression features corresponding to 3 distinct intrinsic gene sets (Sørlie 500, Hu 306 and PAM50 were retrieved for molecular subtype prediction. Results For Sørlie 500 and Hu 306 intrinsic gene set, mean-centring of genes and distance-weighted discrimination (DWD remarkably reduced the number of unclassified cases. Regarding pairwise agreement, the highest predictive consistency was found between Hu 306 and PAM50. In all, 150 and 126 samples were assigned into identical subtypes by both Hu 306 and PAM50 genes, under mean-centring and DWD. Luminal B tended to show a higher nuclear grade and have more HER2 over-expression status than luminal A did. No basal-like breast tumours were ER positive, and most HER2-enriched breast tumours showed HER2 over-expression, whereas, only two-thirds of ER negativity/HER2 over-expression tumros were predicted as HER2-enriched molecular subtype. For 44 Taiwanese breast cancers with survival data, a better prognosis of luminal A than luminal B subtype in ER-postive breast cancers and a better prognosis of basal-like than HER2-enriched subtype in ER-negative breast cancers was observed. Conclusions We suggest that the intrinsic signature Hu 306 or PAM50 be used for breast cancers in the Han Chinese population during molecular subtyping. For the prognostic value and decision making based on intrinsic subtypes, further prospective

  19. The evidence for association of ATP2B2 polymorphisms with autism in Chinese Han population.

    Directory of Open Access Journals (Sweden)

    Wen Yang

    Full Text Available BACKGROUND: Autism is a neurodevelopmental disorder with a high estimated heritability. ATP2B2, located on human chromosome 3p25.3, encodes the plasma membrane calcium-transporting ATPase 2 which extrudes Ca(2+ from cytosol into extracellular space. Recent studies reported association between ATP2B2 and autism in samples from Autism Genetic Resource Exchange (AGRE and Italy. In this study, we investigated whether ATP2B2 polymorphisms were associated with autism in Chinese Han population. METHODS: We performed a family based association study between five SNPs (rs35678 in exon, rs241509, rs3774180, rs3774179, and rs2278556 in introns in ATP2B2 and autism in 427 autism trios of Han Chinese descent. All SNPs were genotyped using the Sequenom genotyping platform. The family-based association test (FBAT program was used to perform association test for SNPs and haplotype analyses. RESULTS: This study demonstrated a preferential transmission of T allele of rs3774179 to affected offsprings under an additive model (T>C, Z = 2.482, p = 0.013. While C allele of rs3774179 showed an undertransmission from parents to affected children under an additive and a dominant model, respectively (Z = -2.482, p = 0.013; Z = -2.591, p = 0.0096. Haplotype analyses revealed that three haplotypes were significantly associated with autism. The haplotype C-C (rs3774180-rs3774179 showed a significant undertransmission from parents to affected offsprings both in specific and global haplotype FBAT (Z = -2.037, p = 0.042; Global p = 0.03. As for the haplotype constructed by rs3774179 and rs2278556, C-A might be a protective haplotype (Z = -2.206, p = 0.027; Global p = 0.04, while T-A demonstrated an excess transmission from parents to affected offsprings (Z = 2.143, p = 0.032. These results were still significant after using the permutation method to obtain empirical p values. CONCLUSIONS: Our research suggested that ATP2B2

  20. The localization of type 2 diabetes susceptibility gene loci in northern Chinese Han families

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    We conducted a genome-wide scan,in which 358 well distributed fluorescent dye-labe- led microsatellite marker sets were applied in 32 Chinese Han type 2 diabetes families from Northern China to search for the susceptibility gene loci.The data collected from screening all the chromosomes of genome were genotyped by using genescan and genotyping software,then,parametric and non-parametric multipoint test,and affected sib-pair analysis as well,were used to analyze the data.We identified some susceptibility gene loci residing in chromosomes 1,12,18,20,respectively,or precisely,located around D1S214,D1S207,D1S218,D1S235,D12S336,D18S61 and D20S118.The comparison of this result with those from other regions and races reflected the complexity and heterogeneity of type 2 diabetes.

  1. ALBERT, HANS, Racionalismo crítico. Por Juan A. Estrada

    Directory of Open Access Journals (Sweden)

    Juan A. Estrada

    2013-06-01

    Full Text Available Autor: Hans Albert (2002 Editorial: Síntesis, Madrid, 238 pp.   Desde su tratado sobre la razón crítica, Albert no ha cesado de precisar su concepción filosófica, desde un diálogo constante con Popper y respondiendo a las diversas críticas de la hermenéutica y la fenomenología, de la teoría crítica y de la misma teología. En este volumen ofrece varios trabajos con el subtítulo de «Cuatro capítulos para una sátira del pensamiento ilusorio», precedida de un denso y buen prólogo de Ángeles J. Perona.

  2. The Elite Children in the Han Dynasty%汉代杰出成童

    Institute of Scientific and Technical Information of China (English)

    董海蔚

    2012-01-01

    In the Han Dynasty, as compared to younger children, children aged eight to fifteen- year- old children were regarded as quasi- adult children. Some of them were intelligent, filial piety, had awe - inspiring spirit, even with extraordinary talent and martial skill. They had extraordinary, social influence and were outstanding representatives of children.%在汉代,相对于年龄较小的幼童,八至十五岁年龄段的儿童则属于成童。他们中的一些聪慧、孝顺,有令人折服的气概,甚至具备非凡的辩才及武功。他们有着不凡的社会影响力,是当时儿童群体的杰出代表。

  3. Characteristics of white coat hypertension in Chinese Han patients with type 2 diabetes mellitus.

    Science.gov (United States)

    Zhou, Jianguang; Liu, Changyun; Shan, Peijia; Zhou, Yingqi; Xu, Erli; Ji, Yufeng

    2014-01-01

    This study documented the prevalence and clinical features of white coat hypertension (WCH) among Chinese Han patients with type 2 diabetes mellitus (T2DM). Clinic and ambulatory blood pressure (BP) measurements were compared in 856 patients with T2DM to determine the frequency of WCH (WCH was defined as clinical blood pressure ≥140/90 mmHg and daytime blood pressure hypertension. Age, course of T2DM, male WC were independent protective factors, whereas female sex, smoking and alcohol consumption were independent risk factors for WCH in T2DM. Non-dippers and reverse dippers made up larger proportion of the WCH group (p hypertension (EH), and WCH patients also exhibit significant differences in clinical parameters.

  4. FAIRY-TALE REALISM. HANS CHRISTIAN ANDERSEN AND THE MODERN WORLD OF THINGS

    Directory of Open Access Journals (Sweden)

    Frederike Felcht

    2013-01-01

    Full Text Available According to recent research in literary studies, literature has a specific knowledge about things. My contribution supports this thesis by analyzing the world of things in Hans Christian Andersen's fairy tales. Exemplary readings reveal how Andersen's texts acknowledge the power of things in modern life and how these texts thus question scientific and philosophical concepts of subjectivity that dominated in the nineteenth century. The agency of things in Andersen's texts challenges the ideal of a rational subject that acts autonomously. Current theoretical approaches, notably Actor-Network-Theory, allow us to understand the realism of acting things in Andersen's work. That which is marvelous, which is prevalently used to define the genre Fairy Tale in literary studies, is inherent to modernity. The relationship between magic and modernity is different than expected: modernity consists of an interplay between enchantment and disenchantment.

  5. FAIRY-TALE REALISM. HANS CHRISTIAN ANDERSEN AND THE MODERN WORLD OF THINGS

    Directory of Open Access Journals (Sweden)

    Frederike Felcht

    2013-01-01

    Full Text Available According to recent research in literary studies, literature has a specific knowledge about things. My contribution supports this thesis by analyzing the world of things in Hans Christian Andersen's fairy tales. Exemplary readings reveal how Andersen's texts acknowledge the power of things in modern life and how these texts thus question scientific and philosophical concepts of subjectivity that dominated in the nineteenth century. The agency of things in Andersen's texts challenges the ideal of a rational subject that acts autonomously. Current theoretical approaches, notably Actor-Network-Theory, allow us to understand the realism of acting things in Andersen's work. That which is marvelous, which is prevalently used to define the genre Fairy Tale in literary studies, is inherent to modernity. The relationship between magic and modernity is different than expected: modernity consists of an interplay between enchantment and disenchantment

  6. [Hans Gross as an archaeologist--the significance of archaeology for 'encyclopedic' criminology].

    Science.gov (United States)

    Karl, Stephan; Bachhiesl, Christian

    2014-01-01

    In some cases, forensics and criminology have to cooperate with disciplines that usually are counted among the humanities, e.g. with archaeology. This article examines the significance of this cooperation for the criminological epistemology at the turn of the 19th century. These methodological considerations are illustrated by an example: When Hans Gross, who became the founder of the Austrian School of Criminology later, saw an unusually shaped hill near Feldbach, a town in southern Styria, he assumed this hill to be a burial mound and informed the responsible archaeological authorities immediately. Further investigations showed, however, that this hill was a natural formation. This is an early example for interdisciplinary cooperation, which proves that both in archaeology and in criminology a thorough inspection of the site is decisive for further scientific analysis of the topic of research.

  7. Medieval orthopaedic history in Germany: Hieronymus Brunschwig and Hans von Gersdorff.

    Science.gov (United States)

    Hernigou, Philippe

    2015-10-01

    Hans von Gerssdorff and Hieronymus Brunschwig, who flourished in Germany in the latter half of the fifteenth century, have both left early printed treatises on Surgery which give excellent woodcuts showing pictures of instruments, operations, and costumes, at the end of the medieval period. Hieronymus Brunschwig or Hieronymus Brunschwygk (ca. 1450 - ca. 1512), was a German surgeon (wundartzot), alchemist and botanist. He was notable for his methods of treatment of gunshot wounds. His most influential book was the Buch der Cirurgia. Gersdorff(1455-1529) was a military surgeon who gained wide experience during 40 years of campaigning and was an expert in the treatment of battlefield injuries. His work covers anatomy, surgery, leprosy, and glossaries of anatomical terms, diseases, and medications.

  8. Re-reading "Little Hans": Freud's case study and the question of competing paradigms in psychoanalysis.

    Science.gov (United States)

    Midgley, Nicholas

    2006-01-01

    Psychoanalysts have long recognized the complex interaction between clinical data and formal psychoanalytic theories. While clinical data are often used to provide "evidence" for psychoanalytic paradigms, the theoretical model used by the analyst also structures what can and cannot be seen in the data. This delicate interaction between theory and clinical data can be seen in the history of interpretations of Freud's "Analysis of a Phobia in a Five-Year-Old Boy" ("Little Hans"). Freud's himself revised his reading of the case in 1926, after which a number of psychoanalysts--including Melanie Klein, Jacques Lacan, and John Bowlby--reinterpreted the case in the light of their particular models of the mind. These analysts each found "evidence" for their theoretical model within this classic case study, and in doing so they illuminated aspects of the case that had previously been obscured, while also revealing a great deal about the shifting preoccupations of psychoanalysis as a field.

  9. Continuatio naturae. La arquitectura monástica de Dom Hans van der Laan

    OpenAIRE

    Sainz Gutiérrez, Victoriano

    2009-01-01

    En un texto de carácter autobiográfico redactado hacia el final de su vida, Hans van der Laan señalaba, al recordar sus años de infancia y adolescencia, que el principal objetivo en esos años cruciales para su formación había sido el conocimiento de la naturaleza: «Lento pero seguro escribe, me adentraba en la vida de la naturaleza, siendo consciente de que había sido creada por Dios. Mi hermana mayor, la que murió durante la guerra, tuvo como profesora, tanto en la enseñanza primaria como en...

  10. Suicidal risk factors of recurrent major depression in Han Chinese women.

    Science.gov (United States)

    Zhu, Yuzhang; Zhang, Hongni; Shi, Shenxun; Gao, Jingfang; Li, Youhui; Tao, Ming; Zhang, Kerang; Wang, Xumei; Gao, Chengge; Yang, Lijun; Li, Kan; Shi, Jianguo; Wang, Gang; Liu, Lanfen; Zhang, Jinbei; Du, Bo; Jiang, Guoqing; Shen, Jianhua; Zhang, Zhen; Liang, Wei; Sun, Jing; Hu, Jian; Liu, Tiebang; Wang, Xueyi; Miao, Guodong; Meng, Huaqing; Li, Yi; Hu, Chunmei; Li, Yi; Huang, Guoping; Li, Gongying; Ha, Baowei; Deng, Hong; Mei, Qiyi; Zhong, Hui; Gao, Shugui; Sang, Hong; Zhang, Yutang; Fang, Xiang; Yu, Fengyu; Yang, Donglin; Liu, Tieqiao; Chen, Yunchun; Hong, Xiaohong; Wu, Wenyuan; Chen, Guibing; Cai, Min; Song, Yan; Pan, Jiyang; Dong, Jicheng; Pan, Runde; Zhang, Wei; Shen, Zhenming; Liu, Zhengrong; Gu, Danhua; Wang, Xiaoping; Liu, Xiaojuan; Zhang, Qiwen; Li, Yihan; Chen, Yiping; Kendler, Kenneth Seedman; Flint, Jonathan; Liu, Ying

    2013-01-01

    The relationship between suicidality and major depression is complex. Socio- demography, clinical features, comorbidity, clinical symptoms, and stressful life events are important factors influencing suicide in major depression, but these are not well defined. Thus, the aim of the present study was to assess the associations between the above-mentioned factors and suicide ideation, suicide plan, and suicide attempt in 6008 Han Chinese women with recurrent major depression (MD). Patients with any suicidality had significantly more MD symptoms, a significantly greater number of stressful life events, a positive family history of MD, a greater number of episodes, a significant experience of melancholia, and earlier age of onset. Comorbidity with dysthymia, generalized anxiety disorder (GAD), social phobia, and animal phobia was seen in suicidal patients. The present findings indicate that specific factors act to increase the likelihood of suicide in MD. Our results may help improve the clinical assessment of suicide risk in depressed patients, especially for women.

  11. Improvement of the Han-Kobayashi Rate Region for General Interference Channel-v2

    CERN Document Server

    Hodtani, Ghosheh Abed

    2010-01-01

    Allowing the input auxiliary random variables to be correlated and using the binning scheme, the Han-Kobayashi (HK) rate region for general interference channel is partially improved. The obtained partially new achievable rate region (i) is compared to the HK region and its simplified description, i.e., Chong-Motani-Garg (CMG) region, in a detailed and favorable manner, by considering different versions of the regions, and (ii) has an interesting and easy interpretation: as expected, any rate in our region has generally two additional terms in comparison with the HK region (one due to the input correlation and the other as a result of the binning scheme). Keywords. Interference channel, Input correlation, Binning scheme

  12. Hans-Georg Gadamer’s philosophical hermeneutics: Concepts of reading, understanding and interpretation

    Directory of Open Access Journals (Sweden)

    Paul Regan

    2012-12-01

    Full Text Available Hans-Georg Gadamer’s philosophical hermeneutics is a popular qualitative research interpretive method aiming to explore the meaning of individual experiences in relation to understanding human interpretation. Gadamer identifies that authentic engagement with reading requires awareness of the inter-subjective nature of understanding in order to promote a reflective engagement with the text. The main concepts of Gadamer’s view of reading and understanding are explored in this paper in relation to interpreting text. Concepts such as; inter-subjectivity, Being, authenticity, fore-structure, pre-suppositions, prejudice, temporality and history are all help to enhance health and social science researchers’ understanding of his theory and its application.

  13. Julius Elster and Hans Geitel - Dioscuri of physics and pioneer investigators in atmospheric electricity

    Science.gov (United States)

    Fricke, Rudolf G. A.; Schlegel, Kristian

    2017-01-01

    Julius Elster and Hans Geitel contributed to the physics at the turn of the 19-20th century in many ways. We first summarize the life of these exceptional scientists. Then - owing to the topic of this journal - we focus on their atmospheric electricity research. With their experiments, careful evaluations and ingenious interpretation, Elster and Geitel made important contributions to precipitation electricity, the influence of solar radiation on the electric state of the atmosphere, the nature of charge carriers and the ionization of air by radioactivity. They proved their experimental skills by inventing new instruments with unprecedented accuracy and reliability. A very modern concept was their attitude to undertake long-term measurements at various locations. A section on their recognition in the physics community and their scientific distinctions concludes the paper.

  14. Integrating experimental and observational personality research--the contributions of Hans Eysenck.

    Science.gov (United States)

    Revelle, William; Oehlberg, Katherine

    2008-12-01

    A fundamental aspect of Hans Eysenck's research was his emphasis upon using all the tools available to the researcher to study personality. This included correlational, experimental, physiological, and genetic approaches. Fifty years after Cronbach's call for the reunification of the two disciplines of psychology (Cronbach, 1957) and 40 years after Eysenck's plea for experimental approaches to personality research (H. J. Eysenck, 1966), what is the status of the unification? Should personality researchers use experimental techniques? Do experimental techniques allow us to tease out causality, and are we communicating the advantages of combining experimental with multivariate correlational techniques? We review the progress made since Cronbach's and Eysenck's original papers and suggest that although it is still uncommon to find experimental studies of personality, psychology would benefit from the joint use of correlational and experimental approaches.

  15. Hermeneutics and the philosophy of medicine: Hans-Georg Gadamer's platonic metaphor.

    Science.gov (United States)

    Lingiardi, V; Grieco, A

    1999-09-01

    Taking as our starting point Plato's metaphor of the doctor as philosopher we reflect on some aspects of the epistemological status of medicine. The framework to this paper is the hermeneutics of Hans-Georg Gadamer which shows the paradoxical nature of Western medicine in choosing the body-object as its investigative starting point, while in actual fact dealing with subjects. Gadamer proposes a model of medicine as the art of understanding and dialogue, which is capable of bringing together its various constituent parts, i.e. knowledge, knowing how to do and knowing how to be, in medical practice and in the physician's training. The paper concludes with a brief discussion of the dyadic figure of the physician as Platonic "master of the living totality" and wounded healer, capable of activating the patient's self-healing capacity.

  16. Philosophical hermeneutics and the project of Hans Georg Gadamer: implications for nursing research.

    Science.gov (United States)

    Walsh, K

    1996-12-01

    The paper begins with an overview of the historical roots of philosophical hermeneutics grounded in the work of Husserl and Heidegger. It goes on to explore the philosophical hermeneutics of Hans Georg Gadamer as a philosophy useful to nursing research. The four concepts of prejudice, the fusion of horizons, the hermeneutic circle and play are discussed, as are the implications these concepts have for nursing research. These concepts have been utilized in the author's own research and examples from this research are given to illuminate how these concepts can be shaped to the purposes of nursing research. While the concepts discussed stem from the work of Gadamer, the ways they have been utilized by the author do not represent a Gadamerian method. Gadamer's project is purely philosophical.

  17. Suicidal risk factors of recurrent major depression in Han Chinese women.

    Directory of Open Access Journals (Sweden)

    Yuzhang Zhu

    Full Text Available The relationship between suicidality and major depression is complex. Socio- demography, clinical features, comorbidity, clinical symptoms, and stressful life events are important factors influencing suicide in major depression, but these are not well defined. Thus, the aim of the present study was to assess the associations between the above-mentioned factors and suicide ideation, suicide plan, and suicide attempt in 6008 Han Chinese women with recurrent major depression (MD. Patients with any suicidality had significantly more MD symptoms, a significantly greater number of stressful life events, a positive family history of MD, a greater number of episodes, a significant experience of melancholia, and earlier age of onset. Comorbidity with dysthymia, generalized anxiety disorder (GAD, social phobia, and animal phobia was seen in suicidal patients. The present findings indicate that specific factors act to increase the likelihood of suicide in MD. Our results may help improve the clinical assessment of suicide risk in depressed patients, especially for women.

  18. First survey of parasitic helminths of goats along the Han River in Hubei Province, China.

    Science.gov (United States)

    Yang, Xin; Gasser, Robin B; Fang, Rui; Zeng, Jinrong; Zhu, Kaixiang; Qi, Mingwei; Zhang, Zongze; Tan, Li; Lei, Weiqiang; Zhou, Yanqin; Zhao, Junlong; Hu, Min

    2016-09-01

    Diseases caused by parasitic helminths cause considerable production and economic losses in livestock worldwide. Understanding the epidemiology of these parasites has important implications for controlling them. The main purpose of the present study was to estimate the prevalence of key parasitic helminths in goats along the Han River in Zhanggang, Hubei Province (from January to December 2014). We used faecal flotation and sedimentation techniques as well as PCR-based DNA sequencing to detect and identify helminths. Results showed that the prevalence of helminths was high throughout the year, particularly for gastrointestinal nematodes. These first findings provide useful baseline information for goat helminths in Zhanggang, and a starting point for the implementation of control programs. With an increased expansion of the goat industry in China, the findings also emphasise the need to undertake prevalence surveys in other regions of China where extensive farming practices are used.

  19.  Introduktion til Luhmanns organisationsteori i lyset af hans almene systemteori

    DEFF Research Database (Denmark)

    Tække, Jesper

    2007-01-01

    Jeg vil i denne indledning give en udlægning af Luhmanns teori i fugleperspektiv, der ud fra en videnskabsteoretisk og metametodologisk vinkel henvender sig til interesserede i organisationsteori og organisationskommunikation, der gerne vil tilegne sig Luhmanns organisationsteori i forhold til hans...... overordnede teoriramme. Hver af de følgende artikler tager en problematik op ift. organisationer, fx, værdier og anskueliggør hvordan den kan tænkes ud fra Luhmann. Indledningen selv tager Luhmanns systemteori og udlægger den ved at formidle en række grundbegreber i en sammenhæng der begynder med...... iagttagelsesbegrebet og bevæger sig over autopoiesis, forskellige systemtyper, kommunikation og sociale systemtyper til begrebet organisation. Jeg begynder altså med iagttagelse, med refleksion over muligheden og betingelserne for overhovedet at udsige noget om verden. Ved Luhmann foregår dette uden ontologiske...

  20. Hans Robert Jauss e a hermenêutica literária

    OpenAIRE

    Brizotto, Bruno; Universidade de Caxias do Sul; Bertussi, Lisana Teresinha; Universidade de Caxias do Sul

    2014-01-01

    Exame das relações entre hermenêutica e Estética da recepção, sobretudo da hermenêutica literária, ramo da hermenêutica, cuja organização metodológica é exigida e providenciada por Hans Robert Jauss, um dos maiores expoentes da Escola de Constança, berço da Estética da recepção. Corolário desse exercício é a efetivação de um rico e produtivo diálogo entre a filosofia e os estudos literários.

  1. Genome-Wide Association Study for Autism Spectrum Disorder in Taiwanese Han Population.

    Directory of Open Access Journals (Sweden)

    Po-Hsiu Kuo

    Full Text Available Autism spectrum disorder (ASD is a neurodevelopmental disorder with strong genetic components. Several recent genome-wide association (GWA studies in Caucasian samples have reported a number of gene regions and loci correlated with the risk of ASD--albeit with very little consensus across studies.A two-stage GWA study was employed to identify common genetic variants for ASD in the Taiwanese Han population. The discovery stage included 315 patients with ASD and 1,115 healthy controls, using the Affymetrix SNP array 6.0 platform for genotyping. Several gene regions were then selected for fine-mapping and top markers were examined in extended samples. Single marker, haplotype, gene-based, and pathway analyses were conducted for associations.Seven SNPs had p-values ranging from 3.4~9.9*10-6, but none reached the genome-wide significant level. Five of them were mapped to three known genes (OR2M4, STYK1, and MNT with significant empirical gene-based p-values in OR2M4 (p = 3.4*10(-5 and MNT (p = 0.0008. Results of the fine-mapping study showed single-marker associations in the GLIS1 (rs12082358 and rs12080993 and NAALADL2 (rs3914502 and rs2222447 genes, and gene-based associations for the OR2M3-OR2T5 (olfactory receptor genes, p = 0.02, and GLIPR1/KRR1 gene regions (p = 0.015. Pathway analyses revealed important pathways for ASD, such as olfactory and G protein-coupled receptors signaling pathways.We reported Taiwanese Han specific susceptibility genes and variants for ASD. However, further replication in other Asian populations is warranted to validate our findings. Investigation in the biological functions of our reported genetic variants might also allow for better understanding on the underlying pathogenesis of autism.

  2. [Hans Neuffer (1892-1968). Medical moral philosopher and politician of profession in personal union].

    Science.gov (United States)

    Denis, Réne; Gross, Dominik

    2003-01-01

    Hans Neuffer had a well established, civil familiary background. He was raised according to Christian values and remained a practising Christian until the end of his life. Before 1945 he was no person in public life. In spite of the fact that he disapproved the Nazi rule, he did not practise open resistance. After World War Two politically guiltless physicians were needed. Neuffer had this quality and on top of that he had a talent for organisation. In the beginning he was medical functionary in his swabian hometown Stuttgart. In 1949 he took over tasks as medical functionary nationwide. Under his leadership the German physicians succeeded in creating the structures of self administration, that still exist today. Big improvements in income were achieved. The German physicians profited from this until the seventy years of the last century. In addition to this the German doctors managed to become fully accepted members of the World Medical Association (WMA). Besides his work as medical functionary, Neuffer was occupied with ethical questions. The premise of Neuffer's medical ethics were the physician's close ties to God. The responsibility to God was more important than responsibility to conscience, science, the people or the government. One of the foundations of Neuffer's ethics lies in the doctor's personality. Like an artist the "true" physician felt an inner calling. He possessed high mental capacity and had special psychological abilities. Such high moral, mental and psychological demands could only be fulfilled in freedom. Freedom required an adequate income and physicians' self administration. This kind of medical ethics fitted well to the political aims of West Germany's General Medical Council. The freedom of the medical profession and independence from society or government were crucial positions. Hans Neuffer was a politically and morally guiltless medical functionary. At the end of his presidency in 1959, West Germany's physicians had achieved all

  3. La persona como singularidad concreta en la obra de Hans Urs von Balthasar

    Directory of Open Access Journals (Sweden)

    Anneliese Meis W.

    2001-01-01

    Full Text Available El presente estudio aborda el concepto de persona de Hans Urs von Balthasar en cuanto singularidad concreta, descubierto a través de una intensa lectura analítica de su voluminosa obra, búsqueda a la luz de la pregunta ¿por qué yo soy precisamente yo? En efecto, el teólogo suizo nunca sistematiza su comprensión de persona ­la distingue sí de los conceptos "individuo", "sujeto" y "espíritu­, pese a que se sirve de aquella como de uno de los pilares más significativos de su pensamiento. Los resultados obtenidos evidencian la complejidad de factores conceptuales, que demuestran que el yo tiene su fundamento último en el acto libre del amor infinito, que como tal constituye la persona desde el dinamismo intradivino de las relaciones opuestas entre Padre, Hijo y Espíritu SantoThis paper regards the concept of person as a concrete singularity in Hans Urs Von Balthasar's work. Such concept rose after a deep analytical reading of his voluminous work, in the light of the guiding question; Why am I, precisely I? The Swiss theologian distinguishes person from the concepts "individual", "subject" and "spirit", but he never synthesises his understanding of person, even though he uses it as one of the most significant pillars of his thought. The results obtained from the research confirm the complexity of the conceptual factors, which show that one's self has its deepest foundation in the free act of the infinite love, which as such, constitutes the person from the intra-divine dynamism of the opposed relations between the Father, Son and Holy Spirit

  4. Hans Selye and the development of the stress concept. Special reference to gastroduodenal ulcerogenesis.

    Science.gov (United States)

    Szabo, S

    1998-06-30

    Hans Selye has a historic role in the development of the stress concept. Before his short article in Nature in 1936, the neuroendocrine response to nonspecific injury was thought to be restricted to the release of catecholamines, as recognized by Cannon. Selye was the first to appreciate the crucial role of the adrenal cortex/hypophysis axis in the stress response. He also insisted on the nonspecificity of this neuroendocrine response, and he named the stress-causing agent "stressors". His last major contribution was the distinction between negative, that is, distress, and positive, that is, eustress reactions. The "triad of stress" (adrenal hypertrophy, gastrointestinal ulcers, thymolymphatic atrophy) was also first described by Selye, who was fascinated by the fact that in stressed rodents only gastric and not duodenal ulcers would develop. It was not until the recognition of duodenal ulcerogenic properties of propionitrile and cysteamine as well as the subsequent quantitative structure-activity studies predicting the duodenal ulcerogenic action of complex molecules that pathogenetic investigations allowed a molecular and mechanistic approach for studying the etiology and pathogenesis of duodenal ulceration. Recent studies on the role of sulfhydryls, TRH, ET, and growth factors provide new insights into central and peripheral pre-ulcer pathways. We were surprised to learn that an organ-specific ET-1 release may play a role both in ulcer induction and healing, which seems to start with the expression of immediate early genes such as egr-1 and stimulation of the local synthesis of growth factors such as bFGF and PDGF. Thus, a historic review originating with Hans Selye and extending through the next 60 years allows a cellular and molecular approach to the better understanding of stress-related disorders such as gastroduodenal ulceration.

  5. Disposition and kinetics of tetrabromobisphenol A in female Wistar Han rats

    Directory of Open Access Journals (Sweden)

    Gabriel A. Knudsen

    2014-01-01

    Full Text Available Tetrabromobisphenol A (TBBPA is the brominated flame retardant with the largest production volume worldwide. NTP 2-year bioassays found TBBPA dose-dependent increases in uterine tumors in female Wistar Han rats; evidence of reproductive tissues carcinogenicity was equivocal in male rats. To explain this apparent sex-dependence, the disposition and toxicokinetic profile of TBBPA were investigated using female Wistar Han rats, as no data were available for female rats. In these studies, the primary route of elimination following [14C]-TBBPA administration (25, 250 or 1000 mg/kg was in feces; recoveries in 72 h were 95.7 ± 3.5%, 94.3 ± 3.6% and 98.8 ± 2.2%, respectively (urine: 0.2–2%; tissues: <0.1. TBBPA was conjugated to mono-glucuronide and -sulfate metabolites and eliminated in the bile. Plasma toxicokinetic parameters for a 250 mg/kg dose were estimated based on free TBBPA, as determined by UV/radiometric-HPLC analyses. Oral dosing by gavage (250 mg/kg resulted in a rapid absorption of compound into the systemic circulation with an observed Cmax at 1.5 h post-dose followed by a prolonged terminal phase. TBBPA concentrations in plasma decreased rapidly after an IV dose (25 mg/kg followed by a long elimination phase. These results indicate low systemic bioavailability (F < 0.05, similar to previous reports using male rats. Elimination pathways appeared to become saturated leading to delayed excretion after a single oral administration of the highest dose (1000 mg/kg; no such saturation or delay was detected at lower doses. Chronic high exposures to TBBPA may result in competition for metabolism with endogenous substrates in extrahepatic tissues (e.g., SULT1E1 estrogen sulfation resulting in endocrine disruption.

  6. Association of inflammatory gene polymorphisms with ischemic stroke in a Chinese Han population

    Directory of Open Access Journals (Sweden)

    Zhao Nan

    2012-07-01

    Full Text Available Abstract Background Inflammatory mechanisms are important in stroke risk, and genetic variations in components of the inflammatory response have been implicated as risk factors for stroke. We tested the inflammatory gene polymorphisms and their association with ischemic stroke in a Chinese Han population. Methods A total of 1,124 ischemic stroke cases and 1,163 controls were genotyped with inflammatory panel strips containing 51 selected inflammatory gene polymorphisms from 35 candidate genes. We tested the genotype-stroke association with logistic regression model. Results We found two single nucleotide polymorphisms (SNPs in CCL11 were associated with ischemic stroke. After adjusting for multiple testing using false discovery rate (FDR with a 0.20 cut-off point, CCL11 rs4795895 remained statistically significant. We further stratified the study population by their hypertension status. In the hypertensive group, CCR2 rs1799864, CCR5 rs1799987 and CCL11 rs4795895 were nominally associated with increased risk of stroke. In the non-hypertensive group, CCL11 rs3744508, LTC4S rs730012, FCER1B rs569108, TGFB1 rs1800469, LTA rs909253 and CCL11 rs4795895 were associated with ischemic stroke. After correction for multiple testing, CCR2 rs1799864 and CCR5 rs1799987 remained significant in the hypertensive group, and CCL11 rs3744508, LTC4S rs730012, FCER1B rs569108, TGFB1 rs1800469, LTA rs909253 remained significant in the non-hypertensive group. Conclusions Our results indicate that inflammatory genetic variants are associated with increased risk of ischemic stroke in a Chinese Han population, particularly in non-hypertensive individuals.

  7. Pen size and parity effects on maternal behaviour of Small-Tail Han sheep.

    Science.gov (United States)

    Lv, S-J; Yang, Y; Dwyer, C M; Li, F-K

    2015-07-01

    The aim of this experiment was to study the effects of pen size and parity on maternal behaviour of twin-bearing Small-Tail Han ewes. A total of 24 ewes were allocated to a 2×2 design (six per pen), with parity (primiparous or multiparous) and pen size (large: 6.0×3.0 m; small: 6.0×1.5 m) as main effects at Linyi University, Shandong Province, China. Behaviour was observed from after parturition until weaning. All ewes were observed for 6 h every 5 days from 0700 to1000 h and from 1400 to 1700 h. Continuous focal animal sampling was used to quantify the duration of maternal behaviours: sucking, grooming and following as well as the frequency of udder accepting, udder refusing and low-pitched bleating. Oestradiol and cortisol concentrations in the faeces (collected in the morning every 5 days) were detected using EIA kits. All lambs were weighed 24 h after parturition and again at weaning at 35 days of age. The small pen size significantly reduced following (Pprimiparous ewes (Pprimiparous ewes (P<0.001), and ewes in small pens had higher faecal cortisol levels compared with ewes in larger pens (P<0.001). As lambs increased in age, the duration of maternal grooming, following and suckling as well as frequency of udder acceptance and low-pitched bleating all declined, and the frequency of udder refusing increased (P<0.001 for all). Ewe parity, but not pen size, affected lamb weight gain during the period of observation (P<0.001). This is the first study to show that pen size, interacting with parity, can affect the expression of maternal behaviour in sheep during lactation. The study is also the first to report on the maternal behaviour of Chinese native sheep breeds (Small-Tail Han sheep), with implications for the production of sheep in China.

  8. Incidence and Simple Prediction Model of Hyperuricemia for Urban Han Chinese Adults: A Prospective Cohort Study

    Science.gov (United States)

    Cao, Jin; Wang, Chunxia; Zhang, Guang; Ji, Xiang; Liu, Yanxun; Sun, Xiubin; Yuan, Zhongshang; Jiang, Zheng; Xue, Fuzhong

    2017-01-01

    Background: Hyperuricemia (HUA) contributes to gout and many other diseases. Many hyperuricemia-related risk factors have been discovered, which provided the possibility for building the hyperuricemia prediction model. In this study we aimed to explore the incidence of hyperuricemia and develop hyperuricemia prediction models based on the routine biomarkers for both males and females in urban Han Chinese adults. Methods: A cohort of 58,542 members of the urban population (34,980 males and 23,562 females) aged 20–80 years old, free of hyperuricemia at baseline examination, was followed up for a median 2.5 years. The Cox proportional hazards regression model was used to develop gender-specific prediction models. Harrell’s C-statistics was used to evaluate the discrimination ability of the models, and the 10-fold cross-validation was used to validate the models. Results: In 7139 subjects (5585 males and 1554 females), hyperuricemia occurred during a median of 2.5 years of follow-up, leading to a total incidence density of 49.63/1000 person years (64.62/1000 person years for males and 27.12/1000 person years for females). The predictors of hyperuricemia were age, body mass index (BMI) systolic blood pressure, serum uric acid for males, and BMI, systolic blood pressure, serum uric acid, triglycerides for females. The models’ C statistics were 0.783 (95% confidence interval (CI), 0.779–0.786) for males and 0.784 (95% CI, 0.778–0.789) for females. After 10-fold cross-validation, the C statistics were still steady, with 0.782 for males and 0.783 for females. Conclusions: In this study, gender-specific prediction models for hyperuricemia for urban Han Chinese adults were developed and performed well.

  9. Role of IL-17 Variants in Preeclampsia in Chinese Han Women.

    Directory of Open Access Journals (Sweden)

    Haiyan Wang

    Full Text Available Previous studies have suggested an important role for IL-17, mainly secreted by Th17 cells, in the development of systemic inflammation in preeclampsia (PE. This study therefore investigated the association between genetic variants in IL-17A, IL-17F, and IL-17RA and susceptibility to PE in Chinese Han women. We recruited 1,031 PE patients and 1,298 controls of later pregnant women, and used TaqMan allelic discrimination real-time PCR to genotype the polymorphisms of IL17A rs2275913, IL-17F rs763780, and IL-17RA rs4819554. No significant differences in genotypic or allelic frequencies were found at all three polymorphic sites between PE patients and controls (rs2275913: genotype χ2 = 0.218, p = 0.897 and allele χ2 = 0.157, p = 0.692, OR = 1.024, 95%CI 0.911-1.152; rs763780: genotype χ2 = 1.948, p = 0.377 and allele χ2 = 1.242, p = 0.265, OR = 0.897, 95%CI 0.741-1.086; rs4819554: genotype χ2 = 0.633, p = 0.729 and allele χ2 = 0.115, p = 0.735, OR = 1.020, 95%CI 0.908-1.146. There were also no significant differences in genetic distributions between mild/severe PE or early/late-onset PE and control subgroups. Our data indicate that the genetic variants of rs2275913 in IL-17A, rs763780 in IL-17F, and rs4819554 in IL-17RA may not play a role in the pathogenesis of PE in Chinese Han women. However, these findings should be confirmed in other ethnic populations.

  10. Population data of 21 non-CODIS STR loci in Han population of northern China.

    Science.gov (United States)

    Yuan, Li; Ge, Jianye; Lu, Di; Yang, Xue

    2012-07-01

    Allele frequencies and forensic statistics of 21 autosomal short tandem repeat loci (i.e., D6S474, D12ATA63, D22S1045, D10S1248, D1S1677, D11S4463, D1S1627, D3S4529, D2S441, D6S1017, D4S2408, D19S433, D17S1301, D1GATA113, D18S853, D20S482, D14S1434, D9S1122, D2S1776, D10S1435 and D5S2500) were estimated in Han population from northern China (n = 220). Significant deviation from Hardy-Weinberg equilibrium was detected only for D22S1045. The observed heterozygosity, the expected heterozygosity, the discrimination power, the probability of paternity exclusion in trios, the probability of paternity exclusion in duos and the polymorphic information content ranged from 0.591 to 0.836, 0.594 to 0.830, 0.762 to 0.948, 0.341 to 0.659, 0.189 to 0.487 and 0.535 to 0.807, respectively. Triallelic patterns were observed at D19S433 and D10S1435. Mutations occurred at D22ATA63, D10S1248, D19S433 and D14S1434 loci with all single-step mutations. The expected mutation rates of these four loci are 0.0042 with 95% confidence interval [0.0001, 0.0232] in a total of 238 meioses. Our results show that these 21 non-CODIS STR loci are highly polymorphic and can be useful for human identification and kinship analysis in Northern Han population in China.

  11. Polymorphisms in CISH gene are associated with persistent hepatitis B virus infection in Han Chinese population.

    Directory of Open Access Journals (Sweden)

    Zhangyong Hu

    Full Text Available BACKGROUND AND AIM: Cytokine-inducible SRC homology 2 domain protein (CISH is the first member of the suppressors of cytokine signaling (SOCS protein family. An association between multiple CISH polymorphisms and susceptibility to infectious diseases has been reported. This study aimed to investigate the possible association of these single nucleotide polymorphisms (SNPs in CISH gene with different outcomes of Hepatitis B virus (HBV infection. METHODS: 1019 unrelated Chinese Han subjects, including 240 persistent asymptomatic HBV carriers, 217 chronic hepatitis B patients, 137 HBV-related liver cirrhosis patients, and 425 cases of spontaneously recovered HBV as controls, were studied. Four SNPs (rs622502, rs2239751, rs414171 and rs6768300 in CISH gene were genotyped with the snapshot technique. Transcriptional activity of the CISH promoter was assayed in vitro using the dual-luciferase reporter assay system. RESULTS: At position rs414171, A allele and AA genotype frequencies were significantly higher in the HBV-resolved group as compared to the persistent HBV infection group. At position rs2239751, TT genotype was further observed in the HBV-resolved group. Using asymptomatic HBV carriers as controls, our results indicated that the rs414171 and rs2239751 polymorphisms were unrelated to HBV progression. The other two SNPs (rs622502 and rs6768300 showed no association with persistent HBV infection. Haplotype analysis revealed that the GGCA haplotype was associated with spontaneous clearance of HBV in this population. Moreover, luciferase activity was significantly higher in the PGL3-Basic-rs414171T construct as compared to the PGL3-Basic-rs414171A construct (p<0.001. CONCLUSION: Two SNPs (rs414171 and rs2239751 in the CISH gene were associated with persistent HBV infection in Han Chinese population, but not with HBV progression.

  12. Genetic Analysis of IL-17 Gene Polymorphisms in Gout in a Male Chinese Han Population.

    Directory of Open Access Journals (Sweden)

    Zheng Zhou

    Full Text Available Interleukin (IL-17 is a proinflammatory cytokine mainly secreted by activated T helper 17 cells and involved in inflammatory immune responses. This study aimed to investigate the association between IL-17 variants as well as serum IL-17 levels with gout in male Chinese Han individuals. A total of 1,101 male gout patients and 1,239 ethic-matched controls were enrolled. Genetic distributions of three variants (rs2275913 in IL-17A, rs763780 in IL-17F, and rs4819554 in IL-17RA were detected by real-time polymerase chain reaction using the Taqman probe method. The plasma concentrations of IL-17A and IL-17F were measured in 228 gout patients and 198 controls that came from above samples by an enzyme-linked immunosorbent assay. No significant differences were observed in the genetic distribution of these polymorphisms between cases and controls (rs2275913: χ2 = 0.15, p = 0.928 by genotype, χ2 = 0.14, p = 0.711 by allele; rs763780: χ2 = 2.24, p = 0.326 by genotype, χ2 = 0.26, p = 0.609 by allele; rs4819554: χ2 = 1.79, p = 0.409 by genotype, χ2 = 1.46, p = 0.227 by allele. Levels of serum IL-17A and IL-17F were significantly decreased in gout patients (both p0.05. Although the genetic variants in IL-17 we studied in this research do not appear to be involved in the development of gout in male Chinese Han individuals, the IL-17 cytokine family may participate in gouty inflammation in an undefined way, which requires further validation.

  13. Relevance Study on Cerebral Infarction and Resistin Gene Polymorphism in Chinese Han Population

    Science.gov (United States)

    Yan, Aijuan; Cai, Gaoyu; Fu, Ningzhen; Feng, Yulan; Sun, Jialan; Maimaiti, Yiming; Zhou, Weijun; Fu, Yi

    2016-01-01

    Recent research on genome-wide associations has implicated that the serum resistin level and its gene polymorphism are associated with cerebral infarction (CI) morbidity and prognosis, and could thereby regulate CI. This study aimed to investigate the association between the resistin single nucleotide polymorphism (SNP) and the susceptibility to CI in the Chinese Han population. A total of 550 CI patients and 313 healthy controls were genotyped. Nine SNPs of the resistin gene previously shown were sequenced and assessed for an association with CI. The numbers of GG genotype carriers of rs3219175 and rs3486119 in the CI group were significantly higher than those in the control group among the middle-aged group (aged 45-65), at 76% vs 67.9% (P=0.025) and 75.5% vs 67.9% (P=0.031). rs3219175 and rs34861192 were associated with CI in the dominant and superdominant models according to the genetic model analysis (P<0.05). Meanwhile, there was strong linkage disequilibrium among the rs34124816, rs3219175, rs34861192, rs1862513, rs3745367, 180C/G and rs3745369 sites. In a haplotype analysis, the occurrence rate of the haplotype AGGCAGC was 1.97 times (P<0.05) higher in the patient group than in the control group. In addition, the numbers of GG genotype carriers of rs3219175 and rs3486119 in the middle-aged male CI patients and the middle-aged small artery occlusion (SAO) CI patients were higher than those in the control group (P<0.05). In the Chinese Han middle-aged population, the GG gene type carriers of the resistin gene sites rs3219175 and rs34861192 had a high risk for CI onset, especially in middle-aged male patients and SAO CI in all middle-aged patients. PMID:27699082

  14. Risk Factors, Coronary Severity, Outcome and ABO Blood Group: A Large Chinese Han Cohort Study.

    Science.gov (United States)

    Zhang, Yan; Li, Sha; Zhu, Cheng-Gang; Guo, Yuan-Lin; Wu, Na-Qiong; Xu, Rui-Xia; Dong, Qian; Liu, Geng; Li, Jian-Jun

    2015-10-01

    ABO blood type locus has been reported to have ethnic difference and to be a pivotal genetic determinant of cardiovascular risk, whereas few prospective data regarding the impact on cardiovascular outcomes are available in a large cohort of patients with angiography-proven coronary artery disease, especially from the Chinese population. The objective of this study was to assess the prognostic role of blood type in future cardiovascular events (CVEs) in Chinese Han patients undergoing coronary angiography.The population of this prospective cohort study consisted of 3823 eligible patients, and followed annually to capture all CVEs. Baseline characteristics and ABO blood type were obtained. Cox proportional hazards models were used to evaluate the risk of ABO blood type on CVEs.New CVEs occurred in 348 patients [263 (10.3%) non-O and 85 (7.8%) O] during a median period of 24.6 months follow-up. Significantly, non-O blood group was related to the presence and severity of coronary atherosclerosis and several risk factors including inflammatory markers. The log-rank test revealed that there was a significant difference between non-O and O blood groups in event-free survival analysis (P = 0.026). In particular, the Cox proportional hazards models revealed that non-O blood type was associated with increased CVEs risk [hazard ratio (95% confidence interval) 1.320 (1.033-1.685)], even after adjusting for potential confounders [adjusted hazard ratio (95% confidence interval) non-O: 1.289 (1.003-1.656); A: 1.083 (0.797-1.472); B: 1.481 (1.122-1.955); AB: 1.249 (0.852-1.831), respectively].Non-O blood type is associated with future CVEs in Chinese Han patients undergoing coronary angiography.

  15. Association of apolipoprotein E 4 polymorphism with cerebral infarction in Chinese Han population

    Institute of Scientific and Technical Information of China (English)

    Zhu-qing JIN; Wei-feng JI; Jian-gang ZHANG; Yong-sheng FAN; Jing DING; Mei CHEN; Wei FAN; Guang-ji ZHANG; Bin-hui ZHANG; Suo-jing YU; Yong-sheng ZHANG

    2004-01-01

    AIM: To study the association between APOE polymorphisms and cerebral infarction through a case-control study among the Chinese Han population. METHODS: First-ever cerebral infarction patients (n=226) whose ages ranged from 40 to 60 years old were recruited from Department of Neurology, Zhongshan Hospital, Shanghai, and Zhejiang Chinese Traditional Medicine Hospital, Zhejiang, China. Unrelated healthy controls (n=201) were selected from the general population in the same area with similar age and sex distribution. APOE was amplified by one-stage PCR using the forward primer: 5'-GGC ACG GCT GTC CAA GGA GCT-3' and reverse primer: 5'-GAT GGC GCT GAG GCC GCG CT-3'. The PCR product was digested directly with 5 U of CfoI and separated by a 20 % polyacrylamide (acrylamide: bis-acrylamide=29:1) nondenaturing gel. RESULTS: Both cerebral infarction patient and control groups were in Hardy-Weinberg equilibrium. The allele frequency ofAPOE*2, APOE*3, and APOE*4 was 4.6 %,81.9 %, and 13.5 % respectively in the patients with cerebral infarction; 5.7 %, 87.3 %, and 7.0 % respectively in the healthy control group. Compared with APOE3/3 subjects, APOE4/4 carriers had a 2.1-fold risk of cerebral infarction (odds ratio 2.1, 95 % confidence limits 1.3 to 3.4). The allele frequency of APOE*4 in the cerebral infarction patient group was significantly higher than that in the control group (13.5 % vs 7.0 %; P=0.002).CONCLUSION: APOE 4 is a risk factor for cerebral infarction among the Chinese Han population.

  16. CYP7A1 genotypes and haplotypes associated with hypertension in an obese Han Chinese population.

    Science.gov (United States)

    Fu, Lingyu; Zhao, Yanyan; Wu, Xiaomei; Liu, Hong; Shi, Jingpu; Lu, Jingyu; Zhou, Bo

    2011-06-01

    This study investigated the association between single-nucleotide polymorphisms (SNPs; rs3808607 and rs1125226) within the CYP7A1 promoter and hypertension susceptibility in a Han Chinese population. From 2003 through 2006, a population-based case-control study was performed in a cohort of 1187 randomly selected Han Chinese subjects. A sib-pair study for a transmission disequilibrium test analysis was carried out in 76 hypertensive (HT) families (n=312) from northeastern Liaoning province. SNPs were detected using real-time PCR. No significant differences were found in the genotype or allele frequencies of either SNP (P>0.05), with no excessive allele sharing. For rs3808607, the frequency of the AA genotype in obese hypertensive patients was 31.91%, significantly higher than in normotensive (NT) subjects (12.73%; odds ratio (OR)=3.21, 95% confidence interval (CI)=1.35-7.66). For rs3808607, the AA genotype frequency was significantly higher in obese male HT subjects (27.87%) than in matched NTs (7.41%; OR=4.83, 95% CI=1.03-22.65). After adjustment for environmental risk factors in obese participants, the AA genotype was associated with hypertension (OR=3.395, 95% CI=1.412-8.162). Among subjects with body mass index 28 kg m(-2), the HT and NT groups had significantly different frequencies of Hap I (C/C) and Hap IV (A/A). The frequencies of rs3808607 alleles in the CYP7A1 gene differed significantly between obese HT and NT men. Haplotypes I and IV were associated with hypertension in obese participants.

  17. Association between NOS3 genetic variants and coronary artery disease in the Han population.

    Science.gov (United States)

    Zhao, G L; Li, Q J; Lu, H Y

    2016-06-03

    The enzyme endothelial nitric oxide synthase (NOS3) is an important mediator of atherosclerotic disease and is associated with coronary artery disease (CAD). There is growing evidence that polymorphisms in NOS3 influence the progression of CAD; however, there is also a controversy regarding the association of polymorphisms in the gene encoding NOS3 and CAD. To determine if the NOS3 genetic variants are associated with CAD in the Han Chinese, we examined the potential association between CAD and eight single nucleotide polymorphisms (rs1799983, rs2070744, rs11771443, rs3918188, rs2853796, rs7830, rs1541861, and rs2853792) of the NOS3 using the MassARRAY system. The allelic and genotypic frequencies of the rs1799983 (promoter regions) and rs2070744 (intron 1) polymorphisms in patients with CAD were significantly different from those in healthy controls. These patients had significantly higher frequencies of the rs1799983 T allele (χ2 = 7.717, P = 0.007, OR = 1.649, 95%CI = 1.41-2.382) and the rs2070744 G allele (χ2 = 4.548, P = 0.033, OR = 1.490, 95%CI = 1.031-2.153). Strong linkage disequilibrium was observed in three blocks (D' > 0.9). In block 1, significantly more T-T-C haplotypes (χ2 = 5.537, P = 0.019, OR = 0.632, 95%CI = 0.430-0.927) were found in controls. These findings point to a role for NOS3 polymorphisms in CAD in the Chinese Han population, and may be useful for future investigations on the pathogenesis of CAD.

  18. Genetic susceptibility to ulcerative colitis in the Chinese Han ethnic population: association with TNF polymorphisms

    Institute of Scientific and Technical Information of China (English)

    CAO Qian; ZHU Qin; WU Min-liang; HU Wei-ling; GAO Min; SI Jian-min

    2006-01-01

    Background Tumor necrosis factor α (TNFα) is an important proinflammatory cytokine that has been implicated in the pathogenesis of inflammatory bowel disease (IBD). Recent studies have evaluated the role of TNF promoter polymorphisms in IBD, whereas the data are inconsistent. Trans-racial mapping in an ethnically distinct but homogenous population may help clarify these associations. We investigate the association between TNF promoter polymorphisms and susceptibility to ulcerative colitis (UC) in the Chinese Han ethnic population.Methods We studied 110 unrelated UC patients and 292 healthy controls from Zhejiang Province, China.Genotyping for 6 common TNF promoter polymorphisms (TNF -1031T/C, -863C/A, -857C/T, -380G/A,-308G/A, -238G/A) was carried out by polymerase chain reaction sequence-specific primers (PCR-SSP).Results TNF-308A was associated with disease (allele frequency patients 14.6% vs controls 8.9%, P=0.02).TNF -857T was increased in patients but without statistical significance (allele frequency 17.3% vs 12.2%,P=0.06). Haplotype analysis revealed 6 haplotypes including two (H5 and H3), which contained TNF -308A. H5was associated with disease (haplotype frequency patients -12.3% vs controls 7.5%, P=0.03). Of note the rare haplotype H3 has not previously been identified in Caucasian populations. Homozygosity for the haplotype H4comprising the common alleles at each TNF promoter single-nucleotide polymorphism (SNP) was negatively associated with disease (patients vs controls 24.5% vs 34.9%, P<0.05).Conclusions We report the association with TNF -308A polymorphisms in Chinese patients with ulcerative colitis. The functional study in Chinese Han ethnic population is now required.

  19. A single nucleotide polymorphism of the TNRC9 gene associated with breast cancer risk in Chinese Han women.

    Science.gov (United States)

    Chen, F; Zhou, J; Xue, Y; Yang, S; Xiong, M; Li, Y; Liu, Q

    2014-01-01

    A single nucleotide polymorphism (SNP) in the TNRC9 gene was identified as a breast cancer susceptibility genetic variant in recent genome-wide association studies of women of European ancestry. We investigated whether TNRC9 polymorphisms are associated with risk of breast cancer in Chinese women of the Han nationality. We genotyped the SNPs rs3803662, rs1362548, rs1123428 in 870 women, including 388 breast cancer patients and 482 healthy controls, via the PCR-single strand conformation polymorphism procedure and by sequence detection. We found that the T allele and the TT genotype of the SNP rs38033662 is significantly associated with risk for breast cancer in Chinese Han women; however, no significant association was found for rs1362548 or rs1123428. We conclude that SNP rs3803662 is a putative risk factor for breast cancer in Chinese Han women.

  20. Study on the adult physique with the Heath-Carter anthropometric somatotype in the Han of Xi'an, China.

    Science.gov (United States)

    Yang, Li-Tao; Wang, Ning; Li, Zeng-Xian; Liu, Cui; He, Xin; Zhang, Jian-Fei; Han, Hua; Wen, You-Feng; Qian, Yi-Hua; Xi, Huan-Jiu

    2016-03-01

    The study of somatotypes has important significance for medical and physical anthropology as well as sports science. The aim of this study was to understand the somatotype components of the Han population in Xi'an and compare the somatotypes of the Han and five other nationalities in China. The study sample consisted of 429 people of Han nationality (207 males, 222 females) from Xi'an, China, aged ≥20 years old. The Heath-Carter anthropometric method was employed. We evaluated the differences in age and sex by one-way ANOVA and t test. A comparison of somatotypes between the Han and other nationalities was made using the U test. The results showed that the male and female samples all could be classified as having a mesomorphic endomorph profile. The difference in endomorphy was strongest between sexes in all age groups (P < 0.01). There were prominent differences in mesomorphy and ectomorphy between males and females in the 50-59- and ≥60-year-old age groups. In females, the differences in somatotype components appeared to be distinguished between ages (P < 0.01 or P < 0.05). However, in males, there were prominent differences in somatotype components between the 20-29 year olds and all other age groups (P < 0.01 or P < 0.05) except for between those 20-29 and ≥60 years old in endomorphy. Compared with the other five nationalities, there were prominent differences in somatotype components between males and females. These results suggest that the somatotype of the Han population in Xi'an, China, has a predominantly mesomorphic endomorph profile. The endomorphic component shows distinct differences between ages and genders, respectively. Additionally, there are distinct differences in the somatotype components between Xi'an Han and five other nationalities in China in males and females.