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Sample records for latest 20-year experience

  1. Surgical management of gynecomastia: 20 years' experience.

    Science.gov (United States)

    Lapid, O; Jolink, F

    2014-03-01

    Gynecomastia, breast hypertrophy in men, is a common finding. The diagnosis is clinical, and ancillary tests may be performed; however, there is no unanimity in the literature about their use or utility. The mainstay of management is conservative, with a minority of patients being operated on. The surgical treatment of gynecomastia is not restricted to one discipline and is performed by plastic, general, and pediatric surgeons. The aim of this study was to assess the experience treating gynecomastia in a university hospital and the practices of the different surgical disciplines in the diagnosis and surgical treatment of gynecomastia; this knowledge could be used for the formulation of guidelines and the allocation of health-care resources. a university medical center. A retrospective cohort study in which all records of patients operated on for gynecomastia over a 20-year period were retrieved. Data were obtained concerning patient demographics, responsible surgical discipline, the workup and etiology found, the surgical technique used, the occurrence of reoperations and revisions, and the use of pathological examination and its results. A total of 179 patients were treated. There was a difference between the patient groups operated on by the different disciplines regarding the indication, the workup, as well as in the operative techniques used. Plastic surgeons performed more bilateral operations than the other disciplines. Surgeons used more radiology and cytology testing. These results most probably represent differences in the population and pathologies treated. This is possibly due to a bias in the referrals by primary care physicians.

  2. 20-year experience with iatrogenic penile injury.

    Science.gov (United States)

    Amukele, Samuel A; Lee, Gene W; Stock, Jeffrey A; Hanna, Moneer K

    2003-10-01

    We review our experience with the management of iatrogenic penile injuries. Apart from circumcision, serious damage to the penis can occur following hypospadias repair, surgery for priapism or total loss of the penis following surgical repair of bladder exstrophy. A retrospective analysis of patients with iatrogenic penile amputation referred to us between 1980 and 2000 was undertaken. Causes of injury and choice of management were reviewed. Of the 13 cases treated during the 20-year period mechanism of primary injury was circumcision in 4, hypospadias repair in 6, priapism in 1, bladder exstrophy repair in 1 and penile carcinoma in 1. A variety of techniques were used for phallic reconstruction. Penile degloving, division of suspensory ligament and rotational skin flaps achieved penile augmentation and enhancement. Reasonable cosmesis and penile length were achieved in all cases. In indicated cases microsurgical phalloplasty was technically feasible. However long-term followup showed various complications including erosions from the use of a penile stiffener. The ultimate goal of reconstructive surgery is to have a penis with normal function and appearance. The management of penile injury requires a wide variety of surgical techniques that are tailored to the individual patient. Expedient penile reconstruction is successful and therapeutic delay is associated with complications.

  3. [Surgical treatment of esophageal achalasia--20 years experience].

    Science.gov (United States)

    Yaramov, N; Sokolov, M; Angelov, K; Toshev, S; Petrov, B

    2009-01-01

    Achalasia comes from a Greek word that means "failure to relax." Cardiospasm and achalasia refer to the same condition. This report addresses esophageal achalasia--its history, diagnosis, pathophysiology, and treatment options. We report our experience in treating this disorder surgically using modified Heller myotomy combined or not with partial gastric fundoplication. 47 patients with achalasia surgically operated in 20-years period are reported by authors. These features make it reasonable to reasses the relative indications for surgery and nonsurgical therapy in achalasia of the esophagus.

  4. Childhood neoplasms presenting at autopsy: A 20-year experience.

    Science.gov (United States)

    Bryant, Victoria A; Booth, John; Palm, Liina; Ashworth, Michael; Jacques, Thomas S; Sebire, Neil J

    2017-09-01

    The aims of the review are to establish the number of undiagnosed neoplasms presenting at autopsy in a single centre and to determine the incidence and most common causes of sudden unexpected death due to neoplasia in infancy and childhood (SUDNIC). Retrospective observational study of paediatric autopsies performed on behalf of Her Majesty's Coroner over a 20-year period (1996-2015; n = 2,432). Neoplasms first diagnosed at autopsy were identified from an established database and cases meeting the criteria for sudden unexpected death were further categorised. Thirteen previously undiagnosed neoplasms were identified, including five haematological malignancies, two medulloblastomas, two neuroblastomas, two cardiac tumours and two malignancies of renal origin. Eight cases met the criteria for SUDNIC (0.33% of autopsies), the commonest group of which were haematological malignancies (n = 3). Neoplasms presenting as unexpected death in infancy and childhood and diagnosed at autopsy are rare. The findings suggest that haematological malignancies are the commonest cause of SUDNIC and highlight the importance of specialist autopsy in cases of sudden unexpected death. © 2017 Wiley Periodicals, Inc.

  5. Treatment of Pediatric Condylar Fractures: A 20-Year Experience.

    Science.gov (United States)

    Ghasemzadeh, Ali; Mundinger, Gerhard S; Swanson, Edward W; Utria, Alan F; Dorafshar, Amir H

    2015-12-01

    The purpose of this study was to define patterns of injury and treatment for condylar and subcondylar fractures and evaluate short-term outcomes in the pediatric population. A retrospective chart review was performed on pediatric patients with mandibular condylar fractures who presented between 1990 and 2010. Computed tomographic imaging was reviewed for all patients to assess fracture characteristics. Mandibular fractures were codified using the Strasbourg Osteosynthesis Research Group and Lindahl classification methods. Sixty-four patients with 92 condylar fractures were identified. Of these patients, 29 had isolated condylar fracture and 35 had a condylar fracture associated with an additional mandibular arch fracture. The most common fracture patterns were diacapitular fracture in the Strasbourg Osteosynthesis Research Group system (n = 46) and vertical condylar head fracture in the Lindahl system (n = 14). Condylar fracture with additional mandibular arch fractures were treated with maxillomandibular fixation more often than patients with condylar fracture [n = 40 (74.1 percent) versus n = 14 (25.9 percent); p = 0.004]. No condylar fracture was treated in an open fashion. Forty-three patients returned for follow-up. The median follow-up period was 81 days (interquartile range, 35 to 294 days). Ten patients had complications (23.3 percent). The most common complication was malocclusion (n = 5). Nine of 10 patients with complications had condylar fracture with an additional mandibular arch fracture. Closed treatment of condylar fractures yields satisfactory results in pediatric patients. Pediatric patients with condylar fractures combined with additional arch fractures experience a higher rate of unfavorable outcomes.

  6. The OPERA Experiment. Latest results

    Energy Technology Data Exchange (ETDEWEB)

    Hollnagel, Annika [Universitaet Hamburg, Institut fuer Experimentalphysik (Germany); Collaboration: OPERA-Hamburg-Collaboration

    2015-07-01

    The long-baseline neutrino oscillation experiment OPERA has been designed for the direct observation of ν{sub τ} appearance in the CNGS ν{sub μ} beam. The OPERA detector is located at the LNGS underground laboratory, with a distance of 730 km from the neutrino source at CERN. It is a hybrid detector, combining the micrometric precision of emulsion cloud chambers with electronic detector elements for online readout. While CNGS beam data taking lasted from 2008 to 2012, the neutrino oscillation analysis is still ongoing. Updated results with increased statistics are presented, including the recent observation of ν{sub τ} appearance.

  7. Mont Terri rock laboratory, 20 years of research: introduction, site characteristics and overview of experiments

    International Nuclear Information System (INIS)

    Bossart, P.; Bernier, F.; Birkholzer, J.

    2017-01-01

    Geologic repositories for radioactive waste are designed as multi-barrier disposal systems that perform a number of functions including the long-term isolation and containment of waste from the human environment, and the attenuation of radionuclides released to the subsurface. The rock laboratory at Mont Terri (canton Jura, Switzerland) in the Opalinus Clay plays an important role in the development of such repositories. The experimental results gained in the last 20 years are used to study the possible evolution of a repository and investigate processes closely related to the safety functions of a repository hosted in a clay rock. At the same time, these experiments have increased our general knowledge of the complex behaviour of argillaceous formations in response to coupled hydrological, mechanical, thermal, chemical, and biological processes. After presenting the geological setting in and around the Mont Terri rock laboratory and an overview of the mineralogy and key properties of the Opalinus Clay, we give a brief overview of the key experiments that are described in more detail in the following research papers to this Special Issue of the Swiss Journal of Geosciences. These experiments aim to characterise the Opalinus Clay and estimate safety-relevant parameters, test procedures, and technologies for repository construction and waste emplacement. Other aspects covered are: bentonite buffer emplacement, high-pH concrete-clay interaction experiments, anaerobic steel corrosion with hydrogen formation, depletion of hydrogen by microbial activity, and finally, release of radionuclides into the bentonite buffer and the Opalinus Clay barrier. In the case of a spent fuel/high-level waste repository, the time considered in performance assessment for repository evolution is generally 1 million years, starting with a transient phase over the first 10,000 years and followed by an equilibrium phase. Experiments dealing with initial conditions, construction, and waste

  8. Mont Terri rock laboratory, 20 years of research: introduction, site characteristics and overview of experiments

    Energy Technology Data Exchange (ETDEWEB)

    Bossart, P. [Swisstopo, Federal Office of Topography, Wabern (Switzerland); Bernier, F. [Federal Agency for Nuclear Control FANC, Brussels (Belgium); Birkholzer, J. [Lawrence Berkeley National Laboratory, Berkeley (United States); and others

    2017-04-15

    Geologic repositories for radioactive waste are designed as multi-barrier disposal systems that perform a number of functions including the long-term isolation and containment of waste from the human environment, and the attenuation of radionuclides released to the subsurface. The rock laboratory at Mont Terri (canton Jura, Switzerland) in the Opalinus Clay plays an important role in the development of such repositories. The experimental results gained in the last 20 years are used to study the possible evolution of a repository and investigate processes closely related to the safety functions of a repository hosted in a clay rock. At the same time, these experiments have increased our general knowledge of the complex behaviour of argillaceous formations in response to coupled hydrological, mechanical, thermal, chemical, and biological processes. After presenting the geological setting in and around the Mont Terri rock laboratory and an overview of the mineralogy and key properties of the Opalinus Clay, we give a brief overview of the key experiments that are described in more detail in the following research papers to this Special Issue of the Swiss Journal of Geosciences. These experiments aim to characterise the Opalinus Clay and estimate safety-relevant parameters, test procedures, and technologies for repository construction and waste emplacement. Other aspects covered are: bentonite buffer emplacement, high-pH concrete-clay interaction experiments, anaerobic steel corrosion with hydrogen formation, depletion of hydrogen by microbial activity, and finally, release of radionuclides into the bentonite buffer and the Opalinus Clay barrier. In the case of a spent fuel/high-level waste repository, the time considered in performance assessment for repository evolution is generally 1 million years, starting with a transient phase over the first 10,000 years and followed by an equilibrium phase. Experiments dealing with initial conditions, construction, and waste

  9. Rural development and bioenergy - experiences from 20 years of development in Sweden

    International Nuclear Information System (INIS)

    Hillring, B.

    2002-01-01

    Activities have been going on for a number of decades in Sweden in the field of job creation, rural development and development of local economies through the use of bioenergy. This paper relates the experience of different strategies of rural development projects over a 20-year period based on the rapid development of biofuel use, especially wood fuel use in Sweden. A successful strategy for people and companies involved, has been to specify the products and services opposed to bulky raw material production and to integrate them into the companies operations. Another success factor has been size rationalisation. Systems thinking with respect to the market and in different environmental values in the environmental cycle have also been successful. In the future, there will probably be room for different niche companies that can meet the needs of the market that the strongly rationalised companies cannot. This study calls for new studies of direct employment effects and multipliers. Continued internationalisation of the biofuel market will give greater competitiveness and press down prices among local producers. The strong competition will mean that the survivors will be those who are flexible and have activities and products integrated and apply systems thinking where contact will be with different parts of the chain and not only with the production of the raw material.(author)

  10. Surgical Management of Renal Cell Carcinoma Extending Into Venous System: A 20-Year Experience.

    Science.gov (United States)

    Xiao, X; Zhang, L; Chen, X; Cui, L; Zhu, H; Pang, D; Yang, Y; Wang, Q; Wang, M; Gao, C

    2017-11-01

    The purpose of this study is to report our 20-year experience with the surgical management of renal cell carcinoma extending into the inferior vena cava using a novel classification system. We retrospectively reviewed the data of 103 patients (69 males, 34 females, mean age: 52.9 ± 12.6 years) with renal cell carcinoma involving the venous system treated between 1993 and 2014. The inferior vena cava tumor thrombus was classified into five levels: 0 (renal vein, n = 12), 1 (infrahepatic, n = 33), 2a (low retrohepatic, n = 26), 2b (high retrohepatic, n = 19), and 3 (supradiaphragmatic, n = 13). Clinical data were summarized, and overall survival, cancer-specific survival, and disease-free survival were examined by Cox regression analysis. All patients underwent radical surgery. Complete resections of the renal tumor and thrombus were achieved in 101 patients (98.1%). Two intraoperative and one postoperative in-hospital deaths (2.9%) occurred. In total, 19 patients (18.8%) had a total of 29 postoperative complications. Mean follow-up time was 46 months (range, 1-239 months). The 5- and 10-year overall survival rates were 62.9% and 56.0%, respectively. Metastasis, rather than thrombus level, was a significant risk factor associated with overall survival (hazard ratio = 4.89, 95% confidence interval: 2.24-10.67, p system can be used to select the optimal surgical approach and method for patients with renal cell carcinoma and venous thrombus. Its use is associated with prolonged survival and relatively few complications. Metastasis is an independent risk factor of overall survival.

  11. Diagnosis and treatment of congenital choledochal cyst: 20 years' experience in China.

    Science.gov (United States)

    Shi, L B; Peng, S Y; Meng, X K; Peng, C H; Liu, Y B; Chen, X P; Ji, Z L; Yang, D T; Chen, H R

    2001-10-01

    To summarize the experience of diagnosis and treatment of congenital choledochal cyst in the past 20 years (1980-2000). The clinical data of 108 patients admitted from 1980 to 2000 were analyzed retrospectively. Abdominal pain,jaundice and abdominal mass were presented in most child cases. Clinical symptoms in adult cases were non-specific, resulting in delayed diagnosis frequently. Fifty-seven patients (52.7%) had coexistent pancreatiobiliary disease. Carcinoma of the biliary duct occurred in 18 patients (16.6%). Ultrasonic examination was undertaken in 94 cases, ERCP performed in 46 cases and CT in 71 cases. All of the cases were correctly diagnosed before operation. Abnormal pancreatobiliary duct junction was found in 39 patients. Before 1985 the diagnosis and classification of congenital choledochal cyst were established by ultrasonography preoperatively and confirmed during operation, the main procedures were internal drainage by cyst enterostomy. After 1985, the diagnosis was established by ERCP and CT, and cystectomy with Roux-en-Y hepaticojejunostomy was the conventional procedures.In 1994, we reported a new and simplified operative procedure in order to reduce the risk of choledochal cyst malignancy. Postoperative complication was mainly retrograde infection of biliary tract, which could be controlled by the administration of antibiotics, there was no perioperative mortality. The concept in diagnosis and treatment of congenital choledochal cyst has obviously been changed greatly.CT and ERCP were of great help in the classification of the disease.Currently, cystectomy with Roux-en-Y hepaticojejunostomy is strongly recommended as the choice for patients with type I and type IV cysts. Piggyback orthotopic liver transplantation is indicated in type V cysts (Caroli's disease) with frequently recurrent cholangitis.

  12. Surgical treatment of bronchiectasis: A review of 20 years of experience

    Directory of Open Access Journals (Sweden)

    D. Coutinho

    2016-03-01

    Full Text Available Background: Bronchiectasis is defined as an abnormal and irreversible dilation and distortion of the bronchi, which has numerous causes. Surgical treatment of this disease is usually reserved for focal disease and when the medical treatment is no longer effective. We report our center experience and outcomes in bronchiectasis surgery during the last 20 years. Methods: Between 1994 and 2014, sixty-nine patients underwent surgical resection for bronchiectasis. Patient demographics, presenting symptoms, indications for surgical treatment, type of lung resection, morbidity and mortality, as well as clinical follow-up and outcomes were analyzed. Results: From the 69 patients included, 31 (44.9% were male and 38 (55.1% were female. Surgery was indicated because of unsuccessful medical therapy in 33 patients (47.8%, haemoptysis in 22 patients (31.9%, nondiagnostic lung mass in 9 patients (13.0% and lung abscess in 5 patients (7.3%. The surgical procedures were lobectomy in 45 (65.2% patients, pneumonectomy in 10 (14.5% patients, bilobectomy in 8 (11.6% patients, lobectomy plus segmentectomy in 3 (4.3% patients and only segmentectomy in 3 (4.3% patients. Morbidity rate was 14.5% and there was no perioperative mortality. The follow-up was possible in 60 patients, with an outcome reported as excellent in 44 (73.3% patients, as improved in 11 (18.3% and as unchanged in 5 (8.3%. Conclusion: Although the number of patients with bronchiectasis referred for surgical treatment has decreased, pulmonary resection still plays a significant role. Surgical resection of localized bronchiectasis is a safe procedure with proven improvement of quality of life for the majority of patients. Keywords: Bronchiectasis, Thoracic surgery

  13. Meningitis and Meningoencephalitis among Israel Defense Force Soldiers: 20 Years Experience at the Hadassah Medical Centers.

    Science.gov (United States)

    Pikkel, Yoav Y; Ben-Hur, Tamir; Eliahou, Ruth; Honig, Asaf

    2015-11-01

    Meningitis and meningoencephalitis pose major risks of morbidity and mortality. To describe 20 years of experience treating infections of the central nervous system in Israel Defense Force (IDF) soldiers, including the common presentations, pathogens and sequelae, and to identify risk groups among soldiers. All soldiers who were admitted to the Hadassah University Medical Center (both campuses: Ein Kerem and Mt. Scopus) due to meningitis and meningoencephalitis from January 1993 to January 2014 were included in this retrospective study. Clinical, laboratory and radiologic data were reviewed from their hospital and army medical corps files. Attention was given to patients' military job description, i.e., combat vs. non-combat soldier, soldiers in training, and medical personnel. We identified 97 cases of suspected meningitis or meningoencephalitis. Six were mistakenly filed and these patients were found to have other disorders. Four soldiers were diagnosed with epidural abscess and five with meningitis due to non-infectious in flammatory diseases. Eighty-two soldiers in active and reserve duty had infectious meningitis or meningoencephalitis. Of these, 46 (56.1%) were combat soldiers and 31 (37.8%) non-combat; 20 (29.2%) were soldiers in training, 10 (12.2%) were training staff and 8 (9.8%) were medical staff. The main pathogens were enteroviruses, Epstein-Barr virus an d Neisseria meningitidis. In our series, soldiers in training, combat soldiers and medical personnel had meningitis and meningoencephalitis more than other soldiers. Enteroviruses are highly infectious pathogens and can cause outbreaks. N. meningitidis among IDF soldiers is still a concern. Early and aggressive treatment with steroids should be considered especially in robust meningoencephalitis cases.

  14. Successes and Challenges in Tobacco Control–Turkish Experience of 20 Years

    Directory of Open Access Journals (Sweden)

    Nazmi Bilir

    2017-12-01

    Full Text Available Turkey has 20 years of experience with tobacco control. The first tobacco control law came into force in 1996. This law banned smoking in some indoor public places and public transportation, selling tobacco products to children, and all kinds of advertisement of tobacco products. The law made it a duty for television networks to broadcast programs and advertisements on the harms of smoking for 90 minutes per month. After 12 years of implementation, the law was amended to include all indoor public places, including hospitality venues, as smoke-free. Political commitment has been important in establishing comprehensive smoke-free policy and implementation. Following the implementation of 100% smoke-free public places, indoor air quality was improved, employees, and clients of hospitality places were more comfortable, and smoking prevalence was reduced. Dr. Margaret Chan, Director General of the World Health Organization (WHO, highlighted Turkey’s success as follows: “Turkey is the first and, to date, the only country in the world to attain the highest implementation score for all of WHO’s MPOWER measures. This is a model for other countries to follow.” However, still there are some areas to be developed. Violations at some indoor public places were seen, particularly at restaurants and bars during the late night period. Although smoking prevalence was reduced, the prevalence is still high and cigarette prices are too low when compared with some other countries. On the other hand, smoking among youth is increasing. More education and awareness programs should be done for the general public, more comprehensive inspections should be performed for smoke-free implementation, and higher taxes on tobacco products should be implemented.

  15. Latest News from the MEG Experiment

    CERN Multimedia

    CERN. Geneva

    2013-01-01

    Within the Standard Model (SM), in spite of neutrino oscillations, the flavor of charged leptons is conserved in very good approximation, and therefore charged Lepton Flavor Violation (cLFV) is expected to be unobservable. On the other hand, most new physics models predict cLFV at a level within the experimental reach, and processes like the mu to e gamma decay became standard probes for physics beyond the SM. The MEG experiment, at the Paul Scherrer Institute (Switzerland), searches for the mu to e gamma decay, down to a Branching Ratio of about 5 10^-13, exploiting the most intense continuous muon beam in the word and innovative detectors. In this seminar, I will present the most recent results from MEG, and the plan for an upgrade of the experiment, aiming at an improvement of the sensitivity by one order of magnitude within this decade.

  16. Latest results from the Double Chooz experiment

    Energy Technology Data Exchange (ETDEWEB)

    Goeger-Neff, Marianne [Physik Department E15, Technische Universitaet Muenchen (Germany); Collaboration: Double Chooz-Collaboration

    2016-07-01

    Double Chooz aims at a precise measurement of the neutrino mixing angle θ{sub 13} through the disappearance of reactor electron antineutrinos. The experiment relies on the measurement of neutrino flux and spectrum with two identical detectors at 400 m and 1000 m from the reactor cores of two nuclear power reactors. anti ν{sub e} are detected by inverse beta decay on free protons in 8.3 tons of Gd-loaded liquid scintillator, providing a unique delayed coincidence signature. Double Chooz has been running since 2011 with the far detector only, providing the first indication for non-zero θ{sub 13} with reactor antineutrinos. With a rate+shape analysis of 467.90 live days from 2011-2013 we obtain a value of sin {sup 2} 2 θ{sub 13}=0.090{sup +0.032}{sub -0.029}. Data taking with the near detector has started beginning of 2015, allowing a significant reduction of both reactor and detector related systematic uncertainties. The talk reviews the most recent results obtained with the far detector only and discuss first data from the near detector.

  17. 20 Years Experience with using Low Cost Launch Opportunities for 20 Small Satellite Missions

    Science.gov (United States)

    Meerman, Maarten; Sweeting, Martin, , Sir

    these larger 'small satellites' are too big to be carried 'piggy-back'. The entrepreneurial efforts of leading FSU rocket &missile organisations in converting existing vehicles to meet the small satellite launch market at an appropriate cost has resulted in the FSU now holding the prime position for providing launches for the small satellite community - and with an excellent track record of successful launches. However, negotiating and completing a Launch Services Agreement (LSA) for a nano-micro-minisatellite with any launcher organisation is a complex matter and risky territory for the unwary or inexperienced who may easily fall prey to unexpected additional costs and delays. Whilst this warning should be heeded when dealing with European and US organisations, it is particularly relevant when negotiating launches from the FSU where there is a plethora of agencies and organisations offering a bewildering range of launch vehicles and options. Furthermore, the FSU has developed a very different technical and managerial philosophy towards launchers when compared with the west and this can be unnerving to 'first-time buyers'. Organisations experienced in dealing in the FSU will encounter a different but excellent service - once the launch service agreement has been thoroughly and fiercely negotiated in every detail. The inexperienced, however, have encountered frustrating delays, lost opportunities, unexpected taxes and costs for additional services or facilities not originally specified, and bewilderment at the different procedures used in the FSU. Fortunately, all this can be avoided with proper experience and the FSU is the current mainstay for launching small satellites quickly, affordably and reliably. Surrey has unique experience gathered over 20 years in handling launches for 20 small satellites, ranging from a 6kg nanosatellite, 50-100kg microsatellites, and a 325kg minisatellite, using 7 different launchers from the USA, Russia, Ukraine, and Europe. By working

  18. [Primary lymphoma of the central nervous system: 20 years' experience in a referral hospital].

    Science.gov (United States)

    Calderón-Garcidueñas, A L; Pacheco-Calleros, J; Castelán-Maldonado, E; Nocedal-Rustrián, F C

    Primary central nervous system lymphomas (PCNSL) are rare neoplasms. AIM. To study the clinical aspects and the immuno-phenotype of all cases of PCNSL in a 20 years lapse in a referral hospital in Northeastern Mexico. From January 1986 to December 2005 all PCNSL histologically confirmed were studied. The primary lymphomas were 1% of malignant central nervous system neoplasms. 21 cases were studied (ages from 9-70 years) with male predominance (2:1). 24% patients had immuno-suppression. The more frequent clinical data were: papilledema (71%), headache (62%), paresis (48%) and seizures (33%). 33% of patients died during the first six months after diagnosis. The T lymphomas were 19% of cases and corresponded to small cell type. PCNSL are still a diagnostic challenge. Multicenter studies are required in order to determine the best treatment protocol.

  19. Kozloduy NPP - its 20 years operational experience; AEhS `Kozloduy`: 20-letni opyt ehksploatatsii

    Energy Technology Data Exchange (ETDEWEB)

    Yankov, M; Grizanov, I; Sabinov, S [Kombinat Atomna Energetika, Kozloduj (Bulgaria)

    1996-12-31

    The main technical and economic results of 20 year operation of the Kozloduy NPP are summarised. The total electricity produced amounts to more than 200 billions KWh. The energy produced by the plant accounts for more than 40% of the national electricity output since 1993. Details of electricity production in different years by all 6 units are given. The efficiency of units 1-4 (WWER-440) is 29-30% and of units 5-6 (WWER-1000) is 29-33%. The Unit 6 has best characteristics. Since 1989 a safety test is being carried out in cooperation with the IAEA. Units 1 and 2 have been reconstructed in order to enhance safety and reliability. 1 tab.

  20. Use of two calcium concentrations in hemodialysis--report of a 20-year clinical experience.

    Science.gov (United States)

    Seyffart, G; Schulz, T; Stiller, S

    2009-03-01

    Over the past almost 50 years several calcium concentrations in the dialysate (CaD) have been used to balance calcium in hemodialysis (HD) patients but a consensus as to which is most appropriate has not been established. Moreover, since the late 1980s, further confusion has been caused following the use of calcium salts as intestinal phosphate binders. This paper reports results of 387 chronic HD patients with respect to secondary hyperparathyroidism (sHPT) and renal osteodystrophy (ROD) of a single center over 20 years. The most important therapeutic measures applied were use of only 2 CaD, 1.5 and 1.75 mmol/l, with very few exceptions, administration of either calcium-containing or calcium-magnesium-containing and/or calcium-free phosphate binders, no dietary restrictions and continuous compensation of uremic acidosis via dialysate and oral supplements of bicarbonate. Using one of the two CaD and selective administration of different phosphate binders for fine adjustment of serum calcium through this combination, we were able to maintain in the long term almost physiological conditions. With exception of the phosphate metabolism, most physiological functions with regard to sHPT and ROD returned close to normal. As a result, the incidence of hypercalcemia, hypocalcemia, extraosseous, extravascular calcification, bone pain and spontaneous bone fractures was extremely low. We conclude that the clinical advantages of the therapeutic measures, above all precise balance of calcium homeostasis, in our investigation were demonstrated by high survival rates (92% after the first year on HD, 82% after 2, and 55% after 5 years), low incidence of cardiovascular fatalities (about 25%), and very low incidence of sHPT (mostly normal parathyroid hormone levels, 1 parathyrdoidectomy within 20 years).

  1. Hydrocephalus shunt technology: 20 years of experience from the Cambridge Shunt Evaluation Laboratory.

    Science.gov (United States)

    Chari, Aswin; Czosnyka, Marek; Richards, Hugh K; Pickard, John D; Czosnyka, Zofia H

    2014-03-01

    The Cambridge Shunt Evaluation Laboratory was established 20 years ago. This paper summarizes the findings of that laboratory for the clinician. Twenty-six models of valves have been tested long-term in the shunt laboratory according to the expanded International Organization for Standardization 7197 standard protocol. The majority of the valves had a nonphysiologically low hydrodynamic resistance (from 1.5 to 3 mm Hg/[ml/min]), which may result in overdrainage related to posture and during nocturnal cerebral vasogenic waves. A long distal catheter increases the resistance of these valves by 100%-200%. Drainage through valves without a siphon-preventing mechanism is very sensitive to body posture, which may result in grossly negative intracranial pressure. Siphon-preventing accessories offer a reasonable resistance to negative outlet pressure; however, accessories with membrane devices may be blocked by raised subcutaneous pressure. In adjustable valves, the settings may be changed by external magnetic fields of intensity above 40 mT (exceptions: ProGAV, Polaris, and Certas). Most of the magnetically adjustable valves produce large distortions on MRI studies. The behavior of a valve revealed during testing is of relevance to the surgeon and may not be adequately described in the manufacturer's product information. The results of shunt testing are helpful in many circumstances, such as the initial choice of shunt and the evaluation of the shunt when its dysfunction is suspected.

  2. [Pulmonary resection using video-assisted thoracoscopic surgery--20 years experience].

    Science.gov (United States)

    Baste, J-M; Orsini, B; Rinieri, P; Melki, J; Peillon, C

    2014-04-01

    Major lung resection using minimally invasive techniques - video-assisted thoracoscopic surgery (VATS) - was first described 20 years ago. However, its development has been slow in many countries because the value of this approach has been questioned. Different techniques and definitions of VATS are used and this can be confusing for physicians and surgeons. The benefit of minimally invasive thoracic surgery was not always apparent, while many surgeons pointed to suboptimal operative outcomes. Recently, technological advances (radiology, full HD monitor and new stapler devices) have improved VATS outcomes. The objectives of this review are to emphasize the accepted definition of VATS resection, outline the different techniques developed and their results including morbidity and mortality compared to conventional approaches. Minimally invasive thoracic surgery has not been proven to give superior survival (level one evidence) compared to thoracotomy. A slight advantage has been demonstrated for short-term outcomes. VATS is not a surgical revolution but rather an evolution of surgery. It should be considered together with the new medical environment including stereotactic radiotherapy and radiofrequency. VATS seems to be more accurate in the treatment of small lung lesions diagnosed with screening CT scan. In the academic field, VATS allows easier teaching and diffusion of techniques. Copyright © 2014 SPLF. Published by Elsevier Masson SAS. All rights reserved.

  3. Implementation of an Emergency Medicine Research Associates Program: Sharing 20 Years of Experience

    Directory of Open Access Journals (Sweden)

    Vincent DeRienzo

    2018-03-01

    Full Text Available Introduction: The use of research associates (RA programs to facilitate study enrollment in the emergency department was initiated during the mid-1990s. The University of Rochester Medical Center (URMC was an early adopting site for this model, which has experienced considerable growth and development over the past 20 years. Methods: Our goal was to detail the Emergency Department Research Associates (EDRA program processes developed at the URMC that has led to our program’s sustainability and productivity. These processes, and the lessons learned during their development, can assist institutions seeking to establish an RA program or refine an existing program. Results: Defined procedures for selecting, training, and monitoring EDRAs have been created and refined with the goal of maximizing study enrollment and minimizing protocol deviations. Our EDRA program functions as a paid service center for investigators, and our EDRAs engage in a variety of study-related activities including screening and enrolling patients, administering surveys, collecting bio-specimens, and making follow-up calls. Over the past two years, our program has averaged 222 enrollments/month (standard deviation = 79.93, gathering roughly 25 participants per study per month. Conclusion: Our EDRA model has consistently resulted in some of the highest number of enrollments across a variety of recently funded, multi-center studies. Maintaining a high-quality EDRA program requires continual investment on the part of the leadership team, though the benefits to investigators within and outside the department outweigh these costs.

  4. 20 years of experience in the treatment of epidermoid carcinoma of anal canal

    International Nuclear Information System (INIS)

    Torres, M.

    2010-01-01

    Objectives: An experimental, longitudinal, prospective and descriptive study was designed (Phase II) with the purpose to evaluate the efficacy of concomitant chemoradiotherapy in local control, toxicity and survival squamous cell carcinoma Anal Canal. Material and Methods: Between 01/01/1989 and 31/12/2008, 120 consecutive patients were treated who had not received any cancer treatment, and did not show neoplasia simultaneously and all were HIV (-). The average age was 59.3 years (Range 34-74) and 80% were females; the performance status was 0-2 ECOG and the TNM (AJCC) classification in the distributed: T1, 36 (30%); T2, 43 (36%); T3 17 (14%); T4, 24 (20%); N0, 86 (72%); N1, 24 (20%); N2, 5 (4%); N3, 5 (4%); M0, 120 (100%). Radiotherapy megavoltage photons used as recommended ICRU-50 (GTV, CTV, PTV); a conventional fractionation was used with fractions 1.8 Gy daily, 5 times per week until 50.40 Gy, using multiple fields ( b ox technique ) ; CDDP chemotherapy was administered, 75 mg / m2 i / v 1 and 24 and 5-FU, 1000 mg / m2 continuous infusion i / v on days 1-5, and 24-28 the course of radiotherapy. The monitoring and the objective of the evaluation was performed according to the RTOG / EORTC and the Kaplan-Meyer recommendations. Results: Local control was : complete remission, 84%; partial remission, 2%; lesional stabilization, 6%; lesion progression, 8%; toxicity was cutaneous, gastrointestinal, and peripheral haematological, grades 2 and 3, and primarily acute neuropathy; There were no deaths due to the combined proceeding or increase colostomies. Survival Overall at 5, 10, 15 and 20 years it was 80%, 75%, 72% and 72% respectively. Conclusions: 1)The results of our study are comparable to those reported in the international literature; 2) Reconsider the current indications of the radiotherapy ( s plit-course, boost, total dose ) and chemotherapy ( i nduction adjuvant, new drugs ) ; 3) The concomitant radiochemotherapy remains the treatment universally accepted

  5. Development of an ICSBEP Benchmark Evaluation, Nearly 20 Years of Experience

    International Nuclear Information System (INIS)

    Briggs, J. Blair; Bess, John D.

    2011-01-01

    The basic structure of all ICSBEP benchmark evaluations is essentially the same and includes (1) a detailed description of the experiment; (2) an evaluation of the experiment, including an exhaustive effort to quantify the effects of uncertainties on measured quantities; (3) a concise presentation of benchmark-model specifications; (4) sample calculation results; and (5) a summary of experimental references. Computer code input listings and other relevant information are generally preserved in appendixes. Details of an ICSBEP evaluation is presented.

  6. Oregon's Death With Dignity Act: 20 Years of Experience to Inform the Debate.

    Science.gov (United States)

    Hedberg, Katrina; New, Craig

    2017-10-17

    Twenty years ago, Oregon voters approved the Death With Dignity Act, making Oregon the first state in the United States to allow physicians to prescribe medications to be self-administered by terminally ill patients to hasten their death. This report summarizes the experience in Oregon, including the numbers and types of participating patients and providers. These data should inform the ongoing policy debate as additional jurisdictions consider such legislation.

  7. 20 years of local ecological public health: the experience of Sandwell in the English West Midlands.

    Science.gov (United States)

    Middleton, J; Saunders, P

    2015-10-01

    A long-term picture of the economy and living conditions of Sandwell, an area of England's industrial Midlands, is presented to explore how these underpin and influence its 'health economy'. Sandwell's experience illustrates how public health actors have to tackle industrial and other factors which shape human health. The paper explores how the ecological public health perspective has helped inform the modern public health task in an area such as Sandwell. Some lessons are offered, including: the need to understand the specific economic legacy of a local area (in Sandwell, principally one of polluting and then declining manufacturing industries); the continuing story of infection control; the complexity of tackling poor diet; and the importance of the built environment and town planning. Faced by such challenges, local public health action represents, in effect, an attempt to transcend unecological public health. This can be exciting, innovative and ultimately successful; but it also means being prepared to face daunting and politically charged obstacles and superior national or international forces over which local public health practitioners conventionally have little leverage. The paper argues that, in such unequal power circumstances, public health practitioners have to draw on the creativity within the local population and build a facilitative alliance of formal and informal pro-public health actors. Despite the confounding odds and ever-present stretched resources, the Sandwell experience gives grounds for optimism, being a story of constant creativity and effective local alliances. Copyright © 2015 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved.

  8. Long Term Sequelae of Pediatric Craniopharyngioma – Literature Review and 20 Years of Experience

    Science.gov (United States)

    Cohen, Michal; Guger, Sharon; Hamilton, Jill

    2011-01-01

    Craniopharyngioma are rare histologically benign brain tumors that develop in the pituitary–hypothalamic area. They may invade nearby anatomical structures causing significant rates of neurological, neurocognitive, and endocrinological complications including remarkable hypothalamic damage. Information regarding long term implications of the tumors and treatment in the pediatric population is accumulating, and treatment goals appear to be changing accordingly. In this review we aim to present data regarding long term complications of craniopharyngioma in children and adolescents and our experience from a large tertiary center. Hypothalamic dysfunction was noted to be the most significant complication, adversely affecting quality of life in survivors. Obesity, fatigue, and sleep disorders are the most notable manifestations of this dysfunction, and treatment is extremely difficult. Changes in management in recent years show a potential for improved long term outcomes; we found a trend toward less aggressive surgical management and increasing use of adjuvant treatment, accompanied by a decrease in complication rates. PMID:22645511

  9. Long term sequelae of pediatric craniopharyngioma - literature review and 20 years of experience

    Directory of Open Access Journals (Sweden)

    Michal eCohen

    2011-11-01

    Full Text Available Craniopharyngioma are rare histologically benign brain tumors that develop in the pituitary- hypothalamic area. They may invade nearby anatomical structures causing significant rates of neurological, neurocognitive and endocrinological complications including remarkable hypothalamic damage. Information regarding long term implications of the tumors and treatment in the pediatric population is accumulating, and treatment goals appear to be changing accordingly. In this review we aim to present data regarding long term complications of craniopharyngioma in children and adolescents and our experience from a large tertiary center. Hypothalamic dysfunction was noted to be the most significant complication, adversely affecting quality of life in survivors. Obesity, fatigue and sleep disorders are the most notable manifestations of this dysfunction, and treatment is extremely difficult. Changes in management in recent years show a potential for improved long term outcomes; we found a trend towards less aggressive surgical management and increasing use of adjuvant treatment, accompanied by a decrease in complication rates.

  10. [State and developmental trends of urogenital tuberculosis--20 years clinical and pathologic-anatomical experiences].

    Science.gov (United States)

    Köhler, H; Haenselt, V; Endmann, P

    1978-10-01

    On the basis of own experiences of twenty years and taking into consideration the knowledge of other authors the developmental tendency in the treatment of the urogenital tuberculosis is demonstrated, the indications to nephrectomy, resection of the kidney, and epididymectomy are reified as well as kind and sequelae of errors in chemotherapy analysed. From 1958 to 1977 2,868 patients with urogenital tuberculosis were hospitalized in the Central Clinic Bad Berka. Of them about 41% had to undergo an operation. A decrease of the quantity of operations can be observed only in the renal resections, whereas the nephrectomy rate is unchangedly high (16.3% of the own patients) and even shows an increasing tendency since 1975. Comparative examinations show that the pathologo-anatomical picture of the ectomized kidneys has not changed during the period of observation. The knowledge of the symptom-poor course obliges also further on differential-diagnostically to take into consideration the urogenital tuberculosis. Only on this way the still large number of organ endangering complications may be encountered in time.

  11. Prevalence of Ectopic Breast Tissue and Tumor: A 20-Year Single Center Experience.

    Science.gov (United States)

    Famá, Fausto; Cicciú, Marco; Sindoni, Alessandro; Scarfó, Paola; Pollicino, Andrea; Giacobbe, Giuseppa; Buccheri, Giancarlo; Taranto, Filippo; Palella, Jessica; Gioffré-Florio, Maria

    2016-08-01

    Ectopic breast tissue, which includes both supernumerary breast and aberrant breast tissue, is the most common congenital breast abnormality. Ectopic breast cancers are rare neoplasms that occur in 0.3% to 0.6% of all cases of breast cancer. We retrospectively report, using a large series of breast abnormalities diagnosed and treated, our clinical experience on the management of the ectopic breast cancer. In 2 decades, we observed 327 (2.7%) patients with ectopic breast tissue out of a total of 12,177 subjects undergoing a breast visit for lesions. All patients were classified into 8 classes, according to the classification of Kajava, and assessed by a physician examination, ultrasounds, and, when appropriate, further studies with fine needle aspiration cytology and mammography. All specimens were submitted to the anatomo-pathologist. The most frequent benign histological diagnosis was fibrocystic disease. A rare granulosa cell tumor was also found in the right anterior thoracic wall of 1 patient. Four malignancies were also diagnosed in 4 women: an infiltrating lobular cancer in 1 patient with a lesion classified as class I, and an infiltrating apocrine carcinoma, an infiltrating ductal cancer, and an infiltrating ductal cancer with tubular pattern, occurring in 3 patients with lesions classified as class IV. Only 1 recurrence was observed. We recommend an earlier surgical approach for patients with lesions from class I to IV. Copyright © 2016 Elsevier Inc. All rights reserved.

  12. Outcomes of Reoperative Valve Replacement in Patients with Prosthetic Valve Endocarditis: A 20-Year Experience

    Directory of Open Access Journals (Sweden)

    Young Woong Kim

    2018-02-01

    Full Text Available Background: Prosthetic valve endocarditis (PVE is a serious complication of cardiac valve replacement, and many p atients with P VE r equire r eoperation. The aim of t his study was to r eview our institutional 2 0 -year experience of surgical reoperative valve replacement in patients with PVE. Methods: A retrospective study was performed on 84 patients (mean age, 54.8±12.7 years; 51 males who were diagnosed with PVE and underwent reoperative valve replacement from January 1995 to December 2016. Results: PVE was found in 1 valve in 61 cases (72.6%, and in 2 or more valves in 23 cases (27.4%. The median follow-up duration was 47.3 months (range, 0 to 250 months. Postoperative complications occurred in 39 patients (46.4%. Reinfection occurred in 6 cases, all within 1 year. The freedom from reinfection rate at 5 years was 91.0%±3.5%. The overall survival rates at 5 and 10 years were 64.4%±5.8% and 54.3%±7.3%, respectively. In stepwise multivariable Cox proportional hazard models, older age (hazard ratio [HR], 1.48; 95% confidence interval [CI], 1.05 to 2.10; p=0.027 and cardiopulmonary bypass (CPB time (HR, 1.03; 95% CI, 1.00 to 1.0 1; p =0 . 0 33 e merged a s independent risk f actors f or d eath. Conclusion: Older age and a longer CPB time were associated with an increased risk of overall mortality in PVE patients.

  13. CANDU steam generator aging management: Some perspectives after 20 years in-service experience

    International Nuclear Information System (INIS)

    Tapping, R.I.; Nickerson, J.; Subash, N.; Roy, S.

    2002-01-01

    assessment of the future field data. Subtle changes to plant operation and also the unique plant-specific details of materials and design often can have a significant impact on the life capability of this complicated equipment. From the plant-specific assessments, and from the experience from our R and D program and utility interaction, AECL has developed a detailed proactive SG aging management strategy for long and reliable life capability (to 50 years). This proactive strategy has a number of important elements that are recommended to be incorporated into current plant programs. With CANDU plants continuing operation with aging equipment, such as steam generators, AECL is continuing to undertake comprehensive programs to support operations and provide enhanced technologies for performance attainment and improvement in inspection, surveillance and performance/safety analysis methodologies. These technologies are also continuously improved by programs that are targeted to important in-service degradation mechanisms, understanding of the system/equipment tolerance to this degradation, and to measures that can be applied to both new reactors and back fitted to existing plants. Systematic and continuous feedback of experience from operations to the performance programs is another important part of the approach. This paper will outline the results of several CANDU SG condition assessments, and place the recommendations from these assessments in context with effective aging Management programs that need to be followed to achieve economic life. For CANDU 6 utilities, which have had a very good steam generator service record with little or no significant active degradation to date, the paper will outline the approach to proactive aging Management that will see equipment through to long and reliable extended life. Also mentioned will be examples of AECL performance improvement and operations support programs for steam generators. (author)

  14. Operating experience on radiation reduction in the latest BWRs

    International Nuclear Information System (INIS)

    Ohsumi, K.; Uchida, S.; Aizawa, M.; Takagi, K.; Amano, O.; Yamashita, K.

    1988-01-01

    In Japan, BWR plants have been operated commercially since 1970, and the reduction of radiation exposure has been an important concern. The application of the procedure for reducing occupational exposure is incorporated in Japanese Improvement and Standardization Program for LWRs. No.2 and No.4 plants in Fukushima No.2 Nuclear Power Station were designed and constructed as the latest 1,100 MWe BWRs in conformity with the Improvement and Standardization Program. No.2 plant began the commercial operation in February, 1984, and experienced three times of the scheduled annual maintenance outage. No.4 plant began the commercial operation in September, 1987, and the first annual maintenance is scheduled from September, 1988. In this paper, discussion is focused on recent radiation reduction measures, that is the control of iron and nickel in primary coolant for reducing the radiation dose rate in primary systems, based on the experience with No.2 and No.4 plants. The design concept of a low radiation dose rate nuclear power plant, the experience on water chemistry in No.2 plant, the control of iron and nickel in No.4 plant operation and so on are reported. It is believed that these operation experiences contribute to the reduction of occupational exposure in BWR plants currently in operation and in future. (Kako, I.)

  15. Afghan and Kurdish refugees, 8-20 years after resettlement, still experience psychological distress and challenges to well being.

    Science.gov (United States)

    Sulaiman-Hill, Cheryl M R; Thompson, Sandra C

    2012-04-01

    To examine the resettlement experiences and provide data of well being and psychological distress for Afghan and Kurdish refugees settled between eight and 20 years in New Zealand and Australia. Participants completed the Kessler-10 Psychological Distress Scale (K10) and Personal Well Being Index (PWI) for subjective well being. A mixed methods approach was used, with participants also discussing during interview resettlement difficulties, quality of life (QOL) and sources of stress. Data from 81 Muslim participants is reported; all spoke English, were generally well educated with 88% having secondary or tertiary level education, and the majority of those resettled before 2001 lived in Perth. Although psychological distress levels were mostly within the low-moderate risk range, significant differences were observed by gender and employment status. Participants identified a range of ongoing stressors with unemployment of particular concern. Social isolation and a sense that they would never really 'fit in' was also reported by some. Participants particularly valued the safety and improved quality of life in their host communities. Despite their appreciation of the overall resettlement experience, too much time to introspect, separation from family, status dissonance and still occasionally feeling overwhelmed by resettlement challenges is a long-term ongoing reality for some former refugees. Former refugees continue to struggle with unemployment, possible discrimination and loss of status long-term. © 2012 The Authors. ANZJPH © 2012 Public Health Association of Australia.

  16. [Extracorporeal circulation and hypothermy surgery in tumors with vena cava extension: 20 years experience at the University Clinic of Navarra].

    Science.gov (United States)

    Rioja Zuazu, J; Rodríguez-Rubio Cortadillas, F; Zudaire Bergera, J J; Saiz Sansi, A; Rosell Costa, D; Robles García, J E; Rábago, G; Berián Polo, J M

    2008-04-01

    We present our 20 years experience treating patients with vena cava extension in whom an extracorporeal circulation, hypothermia, cardio circulatory arrest (ECC-H-CCA) in order to perform, together with a tumoral resection, a thrombus resection. From 1985 to 2005 a total of 28 retroperitoneal tumor were treated: 25 renal cancers, a Wilms tumor, a paratesticular rabdomiosarcoma, and a pheocromocitoma. All of them had an extension by means of thrombus above the suprahepatics veins. All of them were treated by means of ECC-H-CCA for thrombus extraction. A descriptive study of the serie is performed as well as a Kaplan Meyer survival study. Surgical complications were present within 10 patients (35%), with a surgical mortality of two patients (7%): one intra-operatively because a massive embolism of the lungs and the other because of a lung embolism on the 4th post-operative day. Global actuarial survival was 29.1+/-10% at three years and 17.5+/-8% at five years. Analyzing only who do not have metastatic lesions, nor lymph nodes at diagnosis their three year survival was 50.9+/-16.3% and 32.2+/-16% at five years. Mean while those who have any metastatic lesion at diagnosis their three and five years survival was 20.8+/-12% and 10.4+/-9% respectively. The employ of surgical techniques with ECC-H-CCA with in oncological pathology associated with vena cava thrombus is justified and its employment does not worsen the survival; it is indicated because its results, allowing a complete tumoral resection in a safe and reproducible fashion.

  17. The Ross Procedure in Pediatric Patients: A 20-Year Experience of Ross Procedure in a Single Institution.

    Science.gov (United States)

    Yoon, Dong Woog; Yang, Ji-Hyuk; Jun, Tae-Gook; Park, Pyo Won

    2017-08-01

    The Ross/Ross-Konno procedure is considered a good option for irreparable aortic valve disease in pediatric patients because of its hemodynamic performance and potential for growth of the pulmonary autograft. This study is a review of the long-term results of our 20-year experience with the Ross and Ross-Konno operations in a single institution. Between June 1995 and January 2016, 16 consecutive patients (mean age, 6.0±5.9 years; range, 16 days to 17.4 years) underwent either a Ross operation (n=9) or a Ross-Konno operation (n=7). The study included 12 males and 4 females, with a median follow-up period of 47 months (range, 6 to 256 months). There were no cases of in-hospital or late mortality. Six reoperations were performed in 5 patients. Four patients underwent right ventricular-pulmonary artery (RV-PA) conduit replacement. Two patients underwent concomitant replacement of the pulmonary autograft and RV-PA conduit 10 years and 8 years after the Ross operation, respectively. The rate of freedom from adverse outcomes of the pulmonary autograft was 88% and 70% at 5 and 10 years, respectively. The rate of freedom from valve-related reoperations was 79% and 63% at 5 and 10 years, respectively. Pulmonary autografts demonstrated good durability with low mortality. The Ross/Ross-Konno procedure is a good option that can be performed safely in pediatric patients with aortic valve disease, even in a small-volume center.

  18. [Prevalence of central nervous system tumours and histological identification in the operated patient: 20 years of experience].

    Science.gov (United States)

    Anaya-Delgadillo, Gustavo; de Juambelz-Cisneros, Pedro Pablo; Fernández-Alvarado, Basilio; Pazos-Gómez, Fernando; Velasco-Torre, Andrea; Revuelta-Gutiérrez, Rogelio

    Central nervous system tumours comprise a heterogeneous group of neoplasms with great histological diversity. Despite the rising prevalence of these tumours in developing countries, some places like Mexico and Latin America have no representative studies that show the real impact of these tumours in our population. To describe the characteristics of the primary and secondary tumours of the central nervous system in the last 20 years in a Mexican institution. Patients with histopathological diagnosis from 1993 to 2013 in our institution, grouping them according to WHO classification 2007, characterising them by age group, gender, and anatomical location. There were a total of 511 tumours of the central nervous system. Of those, 292 were women and 219 men, with a ratio 1.3: 1, and a mean age of 49.3 years. Tumours with higher prevalence were: Meningeal tumours, 171 (33%), followed by neuroepithelial, 121 (24%). Astrocytoma had the highest prevalence in paediatric patients, whereas in those older than 20 years it was the meningioma. The supratentorial location was the most involved. This is the first study of a series of cases in Mexico that is performed by taking into account benign and malignant tumours of the central nervous system, with patients of all age groups with a range of 20 years. While this work only represents a retrospective analysis of an institution, it can be a strong indication of the epidemiology of these tumours in our environment. Copyright © 2016. Publicado por Masson Doyma México S.A.

  19. Latest news on SUSY from the ATLAS experiment

    CERN Multimedia

    CERN. Geneva

    2016-01-01

    Despite the absence of experimental evidence, weak scale supersymmetry remains one of the best motivated and studied Standard Model extensions. This talk reports the latest ATLAS results for searches for supersymmetric (SUSY) particles, obtained with 13 to 18 fb-1 of 13 TeV data. Weak and strong production in both R-Parity conserving and R-Parity violating SUSY scenarios are considered. The searches involved final states including jets, missing transverse momentum, light leptons, taus or photons.

  20. Double Valve Replacement (Mitral and Aortic for Rheumatic Heart Disease: A 20-year experience with 300 patients.

    Directory of Open Access Journals (Sweden)

    Prashant Mishra

    2016-09-01

    Full Text Available Introduction: Rheumatic heart disease still remains one of the leading causes of congestive heart failure and death owing to valvular pathologies, in developing countries. Valve replacement still remains the treatment of choice in such patients.The aim of this study wasto analyze the postoperative outcome of  double valve replacement (Mitral and Aortic in patients of rheumatic heart disease. Materials and Methods: Between 1988 and 2008, 300 patients of rheumatic heart disease underwent double (Mitral and Aortic valve replacement with Starr Edwards valve or St Jude mechanical valve prosthesis were implanted. These patients were studied retrospectively for preoperative data and postoperative outcome including causes of early and late deaths and the data was analyzed statistically. Results: The 30-day hospital death rate was 11.3% andlate death occurred in 11.6%. Anticoagulant regimen was followed to maintain the target pro-thrombin time at 1.5 times the control value. The actuarial survival (exclusive of hospital mortality was 92.4%, 84.6%, and 84.4%, per year at 5, 10, and 20 years, respectively Conclusions: In view of the acknowledged advantageof superior durability, increased thromboresistance in our patient population, and its cost effectiveness the Starr-Edwards ball valve or St. Jude valve is the mechanical prosthesis of choice for advanced combined valvular disease. The low-intensity anticoagulant regimen has offered suffcient protection against thromboembolism as well as hemorrhage.

  1. The increasing incidence of paranasal organizing hematoma: a 20-year experience of 23 cases at a single center.

    Science.gov (United States)

    Kim, Jong Seung; Oh, Jong Seok; Kwon, Sam Hyun

    2016-06-01

    Sinonasal organized hematoma is a rare, benign disease that can be locally aggressive and may be mistaken for malignancy. Because of its rarity, the clinical characteristics are not well known. The aim of this study is to investigate the distinguishing features of organized hematoma with an emphasis on incidence change. In this retrospective study, we reviewed the records of 23 patients with organized hematoma confirmed histopathologically among 5,378 patients who underwent endoscopic sinus surgery performed by a single surgeon from January 1995 to December 2014 at a tertiary care center. Clinical symptoms, endoscopic photography, computed tomography, and operative findings were reviewed. We also reviewed the relevant literature. Age, sex, site, origin subsite and histopathology were investigated. A statistical review was performed using R 3.1.2 to examine incidence change. The most common complaint was frequent epistaxis and nasal obstruction (52.1%). Of the 23 patients, eight were women and 15 were men with an age range of 18 to 75 years. (mean 38.9 years). Nine of these hematomas occurred on the right side and 14 on the left side. The predominant occurrence site was the antrum (65%), followed by the septum (17.3%), inferior turbinate (8%), and ethmoid sinus (8%). The incidence steadily increased over 20 years. Investigation of the clinical characteristics and incidence change of organized hematoma can provide useful information. Through analysis of the 23 cases in our study, the age distribution was found to be bimodal and the incidence of organizing hematoma was observed to steadily increase. Clinicians should be aware of these characteristics to avoid misdiagnoses of malignant tumors.

  2. Long-Term Outcomes of Homografts in the Aortic Valve and Root Position: A 20-Year Experience

    Directory of Open Access Journals (Sweden)

    Joo Yeon Kim

    2016-08-01

    Full Text Available Background: The advantages of using a homograft in valve replacement surgery are the excellent hemodynamic profile, low risk of thromboembolism, and low risk of prosthetic valve infection. The aim of this study was to evaluate the long-term outcomes of homograft implantation in the aortic valve position. Methods: This is a retrospective study of 33 patients (>20 years old who underwent aortic valve replacement or root replacement with homografts between April 1995 and May 2015. Valves were collected within 24 hours from explanted hearts of heart transplant recipients (<60 years and organ donors who were not suitable for heart transplantation. The median follow-up duration was 35.6 months (range, 0 to 168 months. Results: Aortic homografts were used in all patients. The 30-day mortality rate was 9.1%. The 1- and 5-year survival rates were 80.0%±7.3% and 60.8%±10.1%, respectively. The 1-, 5-, and 10-year freedom from reoperation rates were 92.3%±5.2%, 68.9%±10.2%, and 50.3%±13.6%, respectively. The 1-, 5-, and 10-year freedom from significant aortic dysfunction rates were 91.7%±8.0%, 41.7%±14.2%, and 25.0%±12.5%, respectively. Conclusion: Homografts had the advantages of a good hemodynamic profile and low risk of thromboembolic events, and with good outcomes in cases of aortitis.

  3. PANCREATODUODENECTOMY (WHIPPLE’S PROCEDURE FOR THE MENAGEMENT OF CARCINOMA OF THE PANCREAS – OWN EXPERIENCE AND 20-YEAR SERIES

    Directory of Open Access Journals (Sweden)

    Stane Repše

    2002-07-01

    Full Text Available Background. Pancreatoduodenectomy – the procedure of choice in patients with pancreatic head cancer – has the reputation as a high risk operation with frequent postoperative complications, high postoperative mortality and poor 5-year survival. The development of the operative technique in the world and in Slovenia is presented. The autor’s own 20-year series of patients resected by this method is analysed.Patients and methods. In the period from Jan. 1981 to Dec. 2000 the author resected 58 patients with pancreatic head or periampular cancer. They underwent presumably radical or only paliative procedure (R0, R1, R2 – 30 patients with periampullary tumours and 28 patients with ductal adenocarcinoma. In 52 patients classical Whipple pancreatoduodenectomy was performed and in 6 patients pylorus preserving pancreatoduodenectomy. In 8 patients it was necessary to enlarge the resection – 4 times to partial resection of portal vein, once to total pancreatectomy, once to extended right hemicolectomy and twice to simultaneous resection of liver methastasis.Results. During postoperative course 6 patients had to be reoperated for surgical complications. Three patients died in the 30 days after operation – postoperative mortality rate 5.2%. Five-year survival rate is known only for the patients who are Slovene residents (38/58. Among them 5 patients lived longer than 5 years (107, 100, 87, 80 and 69 months. At the end of 2001 only 4 resected patients were alive – 2 women (3.5 and 3 years after surgery and 2 men (4 and 3.5 year after surgery. The 5-year survival rate calculated by Kaplan-Meier method is 22.6%.Conclusions. In spite of numerous postoperative complications and high postoperative mortality pancreatoduodenectomy is the method of choice in pancreatic head cancer patients. It is possible to improve the outcome to lower the postoperative mortality below 5% and to raise the 5-year survival of resected patients over 25%.

  4. Package performance evaluation: our latest 30-year experience

    International Nuclear Information System (INIS)

    Malesys, Pierre; Gagner, Laurent

    2006-01-01

    Packages for the transport of radioactive material have to comply with national and / or international regulations. These regulations are widely based on the requirements set forth by the International Atomic Energy Agency (IAEA) in the 'Regulations for the Safe Transport of Radioactive Material'. The packages designed to transport the most demanding contents are submitted to tests for demonstrating their ability to withstand accident conditions of transport. These tests are typically: - a nine-meter drop onto a flat and unyielding surface, - a one-meter drop onto a punch, - a 800 deg. C / 30 minutes fire, and an immersion under a head of water of either 0.9 m, or 15 m or 200 m (depending of the criteria to be considered). During the last 20 years, on several of its package designs, COGEMA LOGISTICS has performed tests and analyses to simulate extremely severe accidents. These tests and analysis include: 1. long duration fire test and deep immersion test on a package designed to transport plutonium oxide powder; - 2. deep immersion tests on scale model of packages designed to transport spent fuel, high level vitrified waste and fresh MOX (uranium and plutonium mixed oxide) fuel; - 3. burial in a soft ground of packages designed to transport spent fuel; - 4. numerical study of the thermal behaviour of packages designed to transport spent fuel and high level vitrified waste; - 5. aircraft crash test on scale models of dual-purpose packages for the transport and storage of spent fuel. The paper will: - review the tests and analysis which were performed; - show that our designs are able to withstand extremely severe conditions; - demonstrate that there is no cliff effect: should a failure occurs, it appears gradually and there is no sudden collapse of the package; - explain how compliance with all the regulatory requirements lead to high performances regarding each of them (for instance, in many cases, the need to meet radiation exposure criteria induces a mechanical

  5. Latest experiences in inspecting the inside of BWR vessel shields

    Energy Technology Data Exchange (ETDEWEB)

    Alberdi, R.; Gonzalez, E.

    2001-07-01

    In the last few years, the owners of BWR nuclear power plants have been forced to address new fuel shield inspection requirements, TECNATOM has responded to this situation by launching the TEIDE projects, which include development of an inspection machine and the corresponding Non-Destructive Tests to examine the inside of this shield. With these projects, TECNATOM has performed more than 12 fuel shield inspections in different countries. This article describes the experience gained in the last three years. (Author)

  6. Latest results from the Soviet-American gallium experiment

    International Nuclear Information System (INIS)

    Gavrin, V.N.; Anosov, O.L.; Faizov, E.L.; Kalikhov, A.V.; Knodel, T.V.; Knyshenko, I.I.; Kornoukhov, V.N.; Mirmov, I.N.; Ostrinsky, A.V.; Pshukov, A.M.; Shikhin, A.A.; Timofeyev, P.V.; Veretenkin, E.P.; Vermul, V.M.; Zatsepin, G.T.; Bowles, T.J.; Elliott, S.R.; Nico, J.S.; O'Brien, H.A.; Wark, D.L.; Wilkerson, J.F.; Cleveland, B.T.; Davis, R. Jr.; Lande, K.; Cherry, M.L.; Kouzes, R.T.

    1992-01-01

    A radiochemical 71 Ga- 71 Ge experiment to determine the primary flux of neutrinos from the Sun began measurements of the solar neutrino flux at the Baksan Neutrino Observatory in 1990. The number of 71 Ge atoms extracted from 30 tons of gallium in 1990 and from 57 tons of gallium in 1991 was measured in twelve runs during the period of January 1990 to December 1991. The combined 1990 and 1991 data sets give a value of 58+17/-24 (stat)±14 (syst) SNU. This is to be compared with 132 SNU predicted by the Standard Solar Model

  7. Latest Results from the Daya Bay Reactor Neutrino Experiment

    CERN Multimedia

    CERN. Geneva

    2014-01-01

    Among all the fundamental particles that have been experimentally observed, neutrinos remain one of the least understood. The Daya Bay Reactor Neutrino Experiment in China consists of eight identical detectors placed underground at different baselines from three groups of nuclear reactors, a configuration that is ideally suited for studying the properties of these elusive particles. This talk will present three sets of results that have just recently been released by the Daya Bay Collaboration: (i) a precision measurement of the oscillation parameters that drive the disappearance of electron antineutrinos at short baselines, (ii) a search for sterile neutrino mixing, and (iii) a high-statistics determination of the absolute flux and spectrum of reactor-produced electron antineutrinos. All of these results extend the limits of our knowledge in their respective areas and thus shed new light on neutrinos and the physics that surround them.

  8. 20 years of experience on treatment of large contaminated components and on clearance of material for recycling

    International Nuclear Information System (INIS)

    Lorenzen, Joachim; Lindberg, Maria; Amcoff, Bjoern; Wirendal, Bo

    2005-01-01

    This paper will describe the treatment of contaminated, large, retired components from NPP:s, at low and intermediate activity waste levels for recycling in Sweden. Decontamination and melting of various large components, as well as other metal scrap, has been conducted at Studsvik since the mid 1980:ies. Experience on clearance for recycling, i.e. for unconditional re-use of the metals in the public domain will be described. The contaminated material may be Co-60 dominated as well as Uranium Bearing Waste. During these years different techniques for decontamination and segmentation as well as pre- and post treatment have been developed and successively applied at Studsvik melting facility in Nykoeping, Sweden. This collective experience is presently used for the planning and treatment of both domestic and foreign larger components, like heat exchangers, reactors vessel heads, turbine parts, steam generators, fuel bottles and Giant boilers. During 2005 one 300 ton full size, 400 m 3 Westinghouse Steam Generator is under treatment using advanced decontamination, segmentation and melting techniques to be applied in a specifically designed and confined environment. The conduction of demonstration projects as well as commercial projects will be explained and described. The Studsvik melting facility is today treating components and scrap metal comprising stainless and carbon steel as well as aluminium, copper, brass and lead. Studsvik RadWaste has licenses for treating not only components from Swedish nuclear facilities but also for processing components from nuclear industries outside Sweden, including temporary import and export within a limited time window for each international project. Direct clearance or clearance after limited decay storage at Studsvik site is possible. The high Recycling Rate is due to optimized production to leave an extremely low percentage of secondary waste, including post-treatment of the secondary waste volume. Further, the waste volume

  9. Genetic and epigenetic divergence between disturbed and undisturbed subpopulations of a Mediterranean shrub: a 20-year field experiment.

    Science.gov (United States)

    Herrera, Carlos M; Bazaga, Pilar

    2016-06-01

    Little is known on the potential of ecological disturbance to cause genetic and epigenetic changes in plant populations. We take advantage of a long-term field experiment initiated in 1986 to study the demography of the shrub Lavandula latifolia , and compare genetic and epigenetic characteristics of plants in two adjacent subplots, one experimentally disturbed and one left undisturbed, 20 years after disturbance. Experimental setup was comparable to an unreplicated 'Before-After-Control-Impact' (BACI) design where a single pair of perturbed and control areas were compared. When sampled in 2005, plants in the two subplots had roughly similar ages, but they had established in contrasting environments: dense conspecific population ('Undisturbed' subpopulation) versus open area with all conspecifics removed ('Disturbed' subpopulation). Plants were characterized genetically and epigenetically using amplified fragment length polymorphism (AFLP) and two classes of methylation-sensitive AFLP (MSAP) markers. Subpopulations were similar in genetic diversity but differed in epigenetic diversity and multilocus genetic and epigenetic characteristics. Epigenetic divergence between subpopulations was statistically unrelated to genetic divergence. Bayesian clustering revealed an abrupt linear boundary between subpopulations closely coincident with the arbitrary demarcation line between subplots drawn 20 years back, which supports that genetic and epigenetic divergence between subpopulations was caused by artificial disturbance. There was significant fine-scale spatial structuring of MSAP markers in both subpopulations, which in the Undisturbed one was indistinguishable from that of AFLP markers. Genetic differences between subpopulations could be explained by divergent selection alone, while the concerted action of divergent selection and disturbance-driven appearance of new methylation variants in the Disturbed subpopulation is proposed to explain epigenetic differences. This

  10. Latest results on b-physics from the ATLAS and CMS experiments

    CERN Document Server

    Pasqualucci, E; The ATLAS collaboration

    2013-01-01

    This paper briefly reviews some of the latest measurements of the ATLAS and CMS experiments at LHC in the b-physics sector, namely the ones on rare and semi-rare B0(s) decays, the parity violation in the b decay and the CP violation parameters in the Bs --> J/psi (μ+μ−)phi(K+K−) process, some of the measurements on heavy quarkonia systems.

  11. Chernobyl - 20 years and beyond

    International Nuclear Information System (INIS)

    Lacronique, J.F.; Deconinck, F.; Govaerts, P.; Eggermont, C.; Cort, M. de; Joulia, J.P.; Dal, A.H.; Balonov, M.; Kenigsberg, J.; Hindie, E.; Havenaar, M.

    2006-01-01

    In commemoration of the Chernobyl accident 20 years ago, the French society for radiation protection (S.F.R.P.) and the Belgian society for radiation protection (B.V.S.A.B.R.) organise jointly a one day colloquium in Brussels. This colloquium is divided in two parts: the first one concerns the technical and organisational aspects of the accident with the scenario and its global impact, the international environmental radioactivity information exchange through the Chernobyl experience, the European Union (E.U.) assistance to mitigate the Chernobyl accident consequences, the crisis communication and management and the lessons learned from them; the second part is devoted to the medical and humanitarian aspects through the thyroid cancers after Chernobyl accident, the health effects in the European Union (E.U.) and the psychological factors affecting health after the Chernobyl disaster. (N.C.)

  12. Chernobyl - 20 years and beyond

    Energy Technology Data Exchange (ETDEWEB)

    Lacronique, J F [Institut de Radioprotection et de Surete Nucleaire, 92 - Fontenay-aux-Roses (France); Deconinck, F; Govaerts, P; Eggermont, C [SCK-CEN - Studiecentrum voor Kernenergie, Centre d' Etude de l' Energie Nucleaire, Mol (Belgium); Cort, M de [Institute for Environment and Sustainability, DG JRC EC (Italy); Joulia, J P [EuropeAid Co-operation Office, EC, Brussels (Belgium); Dal, A H; Balonov, M [International Atomic Energy Agency (IAEA), Vienna (Austria); Kenigsberg, J [Commission on Radiation protection, council of ministry (Belarus); Hindie, E [Universites Paris, 75 (France); Havenaar, M [Amsterdam Univ. (Netherlands)

    2006-07-01

    In commemoration of the Chernobyl accident 20 years ago, the French society for radiation protection (S.F.R.P.) and the Belgian society for radiation protection (B.V.S.A.B.R.) organise jointly a one day colloquium in Brussels. This colloquium is divided in two parts: the first one concerns the technical and organisational aspects of the accident with the scenario and its global impact, the international environmental radioactivity information exchange through the Chernobyl experience, the European Union (E.U.) assistance to mitigate the Chernobyl accident consequences, the crisis communication and management and the lessons learned from them; the second part is devoted to the medical and humanitarian aspects through the thyroid cancers after Chernobyl accident, the health effects in the European Union (E.U.) and the psychological factors affecting health after the Chernobyl disaster. (N.C.)

  13. Recent operating experience during startup testing at latest 1100 MWe BWR-5 nuclear power plants

    International Nuclear Information System (INIS)

    Tanabe, Akira; Tateishi, Mizuo; Kajikawa, Makoto; Hayase, Yuichi.

    1986-01-01

    In June and September 1985, the latest two 1100 Mwe BWR-5 nuclear power plants started commercial operation about ten days earlier than initially expected without any unscheduled shutdown. These latest plants, 2F-3 and K-1, are characterized by an improved core with new 8 x 8 fuel assemblies, highly reliable control systems, advanced control room system and turbine steam full bypass system for full load rejection (2F3). This paper describes the following operating experiences gained during their startup testing. 1) Continuous operation at full load rejection. 2) Stable operation at natural circulating flow condition. 3) 31 and 23 hour short time start up operation. 4) 100-75-100 %, 1-8-1-14 hours daily load following operation. (author)

  14. Latest experience on insertion devices at the National Synchrotron Light Source-II

    International Nuclear Information System (INIS)

    Tanabe, Toshiya; Cappadoro, Peter; Corwin, Todd

    2016-01-01

    National Synchrotron Light Source-II (NSLS-II) is the latest storage ring of 3 GeV energy with the horizontal emittance of the electron beam being 0.9 nm.rad. Nine In-Vacuum Undulators (IVUs) are utilized at the NSLS-II as of February 2016. All IVUs have a unique side window derived from the experience from the CHESS facility in Cornell University. An R and D activity called 'Vacuum Seal Test' was conducted to ensure the viability of aluminum wire seal. Another R and D activity to develop a measurement system for Cryogenic Permanent Magnet Undulator (CPMU) was also performed. Other in-air devices, namely damping wigglers (DWs) and elliptically polarizing undulators (EPUs) utilize extruded aluminum chambers with Non-Evaporable Getter (NEG) coating. The beam-based integral estimates were obtained from the virtual kicks at the upstream and downstream of the undulator that best fit the measured orbit distortion in a model lattice with Tracy. In some cases, there are fairly large discrepancies between magnetic measurement data and observed integrals by the beam. Beam studies were carried out to explain the discrepancies mentioned earlier. The latest experiences on ID development and commissioning are discussed in conjunction with related activities in the world. (author)

  15. Time trends in upper gastrointestinal diseases and Helicobacter pylori infection in a multiracial Asian population--a 20-year experience over three time periods.

    Science.gov (United States)

    Leow, A H-R; Lim, Y-Y; Liew, W-C; Goh, K-L

    2016-04-01

    Marked epidemiological changes in upper gastrointestinal diseases and Helicobacter pylori infection have taken place in the Asian Pacific region. In particular, differences with respect to race in the multiracial Asian population in Malaysia have been important and interesting. A time trend study of upper gastrointestinal disease and H. pylori infection in three time periods: 1989-1990, 1999-2000 and 2009-2010 spanning a period of 20 years was carried out. Consecutive first time gastroscopies carried out on patients attending the University of Malaya Medical Center were studied. Diagnoses and H. pylori infection status were carefully recorded. A steady decline in prevalence of duodenal ulcer (DU) and gastric ulcer (GU) from 21.1% to 9.5% to 5.0% and from 11.9% to 9.4% to 9.9% while an increase in erosive oesophagitis (EO) from 2.0% to 8.4% to 9.5% (chi-square for trend; P Chinese and Indians but the difference over time was most marked in Malays. There was a steady decline in the proportion of patients with gastric and oesophageal cancers. Peptic ulcers have declined significantly over a 20-year period together with a decline in H. pylori infection. In contrast, a steady increase in erosive oesophagitis was observed. Gastric and oesophageal squamous cell cancers have declined to low levels. © 2016 John Wiley & Sons Ltd.

  16. Surgical Treatment of Primary Intracardiac Myxoma: 20-Year Experience in “Shahid Modarres Hospital”—A Tertiary University Hospital—Tehran, Iran

    Directory of Open Access Journals (Sweden)

    Zahra Ansari Aval

    2015-01-01

    Full Text Available Although cardiac tumors are not common they may vary in terms of race and surgical approach in different countries. Method. Patients data of 20 years was collected and evaluated in the “Shahid Modarres Hospital”—a tertiary university hospital—Tehran, Iran. Results. 42 patients with cardiac myxoma (all cases in 20 years were included in study, 17 males and 25 females, age difference: 13 to 76 years (mean 50.6. Most of patients were in functional classes I, II. 35 patients complained of dyspnea and 3 patients had embolic events. 97.6% of tumors were primary (41 patients and one tumor was recurrent (2.4%, 85.7% of tumors (36 cases were located in LA, and 88.1% of tumors (37 cases were pediculated. 40 patients (95% had one tumor. In 22 patients (52.3% after tumor resection septal defects were repaired primarily while in 18 patients (42.8% the defects were repaired with pericardial patch and In one patient, tumor resected without any septal defect. Mean tumor size was about 5.22 cm (range of 2.2 to 8.2 cm. Postoperatively, 33 patients discharged from hospital without any complication. Discussion. The research reveals that patients’ age and gender were similar to that of other studies in other countries while tumor’s incidence seems to be higher. 3 patients were diagnosed after remote embolic event and one patient was diagnosed after MI reflecting relatively high tumor complications and late diagnosis. Conclusion. In our study mean time from diagnosis to operation was too long. The patients had more preoperative embolic events and complication. However, size of myxoma and location of that was as same as its rate in the other literature. As recommendation we suggested that in all patients with vague chest pain or remote embolic events cardiac myxomas should be ruled out.

  17. Latest experiences and future plans on NSLS-II insertion devices

    Energy Technology Data Exchange (ETDEWEB)

    Tanabe, T.; Hidaka, Y.; Kitegi, C.; Hidas, D.; Musardo, M.; Harder, D. A.; Rank, J.; Cappadoro, P.; Fernandes, H.; Corwin, T. [Energy Sciences Directorate, Brookhaven National Laboratory, Upton, NY 11973, U.S.A (United States)

    2016-07-27

    National Synchrotron Light Source-II (NSLS-II) is the latest storage ring of 3 GeV energy at the Brookhaven National Laboratory (BNL). The horizontal emittance of the electron beam with the currently installed six damping wigglers is 0.9 nm.rad, which could be further reduced to 0.5 nm.rad with more insertion devices (IDs). With only one RF cavity the beam current is restricted to 200 mA. Five hundred mA operation is envisaged for next year with an addition of the second cavity. Six (plus two branches) beamlines have been commissioned in the initial phase of the project. In July 2015, three NIH funded beamlines called “Advanced Beamlines for Biological Investigations with X-rays” (ABBIX) will be added for operation. This paper describes the experiences of ID development, installation, and commissioning for the NSLS-II project as well as our future plans to improve the performance of the facility in terms of source development.

  18. Change in the incidence and anatomic distribution of colorectal adenoma and cancer over a period of 20 years: A single center experience

    Directory of Open Access Journals (Sweden)

    Milovanović-Alempijević Tamara

    2018-01-01

    Full Text Available Background/Aim. In recent years, many studies have demonstrated a proximal shift in the distribution of adenomas and colorectal cancers. The aim of this study was to investigate whether there are differences in the incidence and anatomical distribution of adenomas and colorectal cancers spanning a 20 year time gap. Methods. We performed a retrospective observational study of colorectal adenomas and cancers diagnosed during total colonoscopy in a high volume tertiary care facility in two 1-year periods of time – 1990 and 2010. Results. During the analyzed period, 4,048 colonoscopies were performed, 1,148 were performed in 1990 and 2,900 were done in 2010. The study included 466 patients with adenomas and 121 patients with colorectal cancers. Frequency of proximal adenoma changed from 16.5% to 32.7% (p < 0.001. By analyzing colonoscopies in 2010, an increase in the incidence of adenomas compared to 1990 was noticed. The number of adenomas sized 0–5 mm rose from 32.8% to 56.9% (p < 0.001. Frequency of colon carcinoma changed from 5.3% to 2.0% (p < 0.001. Incidence of cancers in the proximal colon rose from 21.3% to 48.4% (p = 0.002. A higher incidence of cancers in the proximal colon and a lower incidence of distal cancers were observed, while no difference was observed in the incidence of rectal cancers. Conclusion. Presence of proximal colon adenoma and cancer is higher, while the overall incidence of colon cancer is lower. This finding should be taken into account when planning the screening for colorectal cancer.

  19. The use of circular external fixators in the management of lower limb trauma in Dublin: a single surgeon's 20-year experience.

    Science.gov (United States)

    O'Neill, B J; Fox, C M; Molloy, A P; O'hEireamhoin, S; Moore, D P

    2016-02-01

    It has been estimated that approximately 520,000 injury presentations are made to Irish accident and emergency departments each year. Fractures account for 20 % of these injuries. Circular external fixators (frames) have been shown to be a safe and effective method of treatment for long bone fractures where internal fixation is impossible or in-advisable. We present the outcomes of all frames applied at our institution for stabilisation of acute fractures over a 20-year period. We retrospectively reviewed a prospectively compiled database of all frames applied in our institution and identified all frames which were applied for acute lower limb trauma. We identified 68 fractures in 63 patients. There were 11 femoral fractures and 57 tibial fractures. All fractures were classified using the AO Classification system, and most fractures were Type C fractures. We used an Ilizarov frame for 53 fractures and a Taylor Spatial Frame for 15 fractures. The mean time in frame was 365 days for a femoral fracture and 230 days for a tibial fracture. There were five tibial non-unions giving an overall union rate of 93 %. Factors associated with non-union included high-energy trauma and cigarette smoking. The vast majority of lower limb fractures can be treated using 'conventional' methods. Complex fractures which are not amenable to open reduction and internal fixation or cast immobilisation can be treated in a frame with excellent results. The paucity of published reports regarding the use of frames for complex trauma reflects the under-utilisation of the technique.

  20. The Titan Haze Simulation Experiment: Latest Laboratory Results and Dedicated Plasma Chemistry Model

    Science.gov (United States)

    Sciamma-O'Brien, Ella; Raymond, Alexander; Mazur, Eric; Salama, Farid

    2018-06-01

    Here, we present the latest results on the gas and solid phase analyses in the Titan Haze Simulation (THS) experiment. The THS experiment, developed at NASA Ames’ COSmIC facility is a unique experimental platform that allows us to simulate Titan’s complex atmospheric chemistry at Titan-like temperature (200 K) by cooling down N2-CH4-based mixtures in a supersonic expansion before inducing the chemistry by plasma.Gas phase: The residence time of the jet-accelerated gas in the active plasma region is less than 4 µs, which results in a truncated chemistry enabling us to control how far in the chain of reactions the chemistry is processing. By adding heavier molecules in the initial gas mixture, it is then possible to study the first and intermediate steps of Titan’s atmospheric chemistry as well as specific chemical pathways, as demonstrated by mass spectrometry and comparison to Cassini CAPS data [1]. A new model was recently developed to simulate the plasma chemistry in the THS. Calculated mass spectra produced by this model are in good agreement with the experimental THS mass spectra, confirming that the short residence time in the plasma cavity limits the growth of larger species [2].Solid phase: Scanning electron microscopy and infrared spectroscopy have been used to investigate the effect of the initial gas mixture on the morphology of the THS Titan aerosol analogs as well as on the level and nature of the nitrogen incorporation into these aerosols. A comparison to Cassini VIMS observational data has shown that the THS aerosols produced in simpler mixtures, i.e., that contain more nitrogen and where the N-incorporation is in isocyanide-type molecules instead of nitriles, are more representative of Titan’s aerosols [3]. In addition, a new optical constant facility has been developed at NASA Ames that allows us to determine the complex refractive indices of THS Titan aerosol analogs from NIR to FIR (0.76-222 cm-1). The facility and preliminary results

  1. Race and association with disease manifestations and mortality in scleroderma: a 20-year experience at the Johns Hopkins Scleroderma Center and review of the literature.

    Science.gov (United States)

    Gelber, Allan C; Manno, Rebecca L; Shah, Ami A; Woods, Adrianne; Le, Elizabeth N; Boin, Francesco; Hummers, Laura K; Wigley, Fredrick M

    2013-07-01

    Experience suggests that African Americans may express autoimmune disease differently than other racial groups. In the context of systemic sclerosis (scleroderma), we sought to determine whether race was related to a more adverse expression of disease. Between January 1, 1990, and December 31, 2009, a total of 409 African American and 1808 white patients with scleroderma were evaluated at a single university medical center. While the distribution by sex was virtually identical in both groups, at 82% female, African American patients presented to the center at a younger mean age than white patients (47 vs. 53 yr; p scleroderma-specific autoantibody status, and for the socioeconomic measures of educational attainment and health insurance status, diminished these risk estimates (RR, 1.3; 95% CI, 1.0-1.6). The heightened risk of mortality persisted in strata defined by age at disease onset, diffuse cutaneous disease, anticentromere seropositivity, decade of care at the center, and among women. These findings support the notion that race is related to a distinct phenotypic profile in scleroderma, and a more unfavorable prognosis among African Americans, warranting heightened diagnostic evaluation and vigilant care of these patients. Further, we provide a chronologic review of the literature regarding race, organ system involvement, and mortality in scleroderma; we furnish synopses of relevant reports, and summarize findings.

  2. The Tutorial Education Program on the Formation of the New Milenium's Meteorologist: 20 Years of Project Experience at Universidade Federal de Pelotas - Brazil

    Science.gov (United States)

    Foster, P.

    2012-12-01

    The Programa de Educação Tutorial (Tutorial Education Program), also known as "PET", has the objective to finance students with potential, encouraging and providing extracurricular activities in order to promote the integration with the academic market and the development of study programs in graduate school, preparing a professional that in the future will operate in a global market, transforming and fighting for the professional interests of their class. The design of the program dates back to 1970 and is based on the model of learning and guidance to form the student. The groups are composed gradually, through an annual selection. The deployment and implementation of the groups consider the inclusion of new members in different stages of their school program, working in an integrated manner. To apply, students must submit satisfactory academic performance, without failures on any course and commit to devote a minimum of twenty hours per week to the program activities. Deployed at Universidade Federal de Pelotas - Brazil, in 1991, the group has contributed to the training of students of Meteorology through the concept of teaching-research-extension activities. We believe that PET has been of utmost importance in the training of the new millennium's professional, given that the objectives of this program seek to provide an excellent level of academic training to undergraduates, encouraging their entry into the graduate studies; stimulating the improvement of the quality of teaching degree through the development of new practices and teaching experience; multiplying the activities developed by scholars and increase their interactions with program's faculty and other students of the institution. With the highly competitive market requiring specialized professionals, the high investment in students with potential can be reversed for the benefit of the profession.

  3. Valve-sparing David I procedure in acute aortic type A dissection: a 20-year experience with more than 100 patients.

    Science.gov (United States)

    Beckmann, Erik; Martens, Andreas; Pertz, Jana; Kaufeld, Tim; Umminger, Julia; Hanke, Jasmin S; Schmitto, Jan D; Cebotari, Serghei; Haverich, Axel; Shrestha, Malakh Lal

    2017-08-01

    The aortic valve-sparing David procedure has been applied to the elective treatment of patients with aortic aneurysms with excellent results. The use of this technique in patients with acute aortic dissection type A (AADA) is still a matter of debate. We present our long-term experience with 109 patients with AADA who had the valve-sparing David I procedure. Between July 1993 and October 2015, 109 patients with AADA had the valve-sparing David I procedure at our centre. We conducted a retrospective review with follow-up. The mean age was 54 ± 12 years; 78 (72%) patients were men. Marfan syndrome was present in 6 (5%) patients and bicuspid aortic valve in 3 (3%). Only 4 (4%) patients received the isolated David procedure; 50 (46%) underwent additional proximal, 13 (12%) subtotal and 42 (39%) total aortic arch replacement. The in-hospital mortality rate was 11% ( n  = 12). Intraoperative/discharge echocardiography showed aortic insufficiency ≤ I° in 93 of 97 patients (96%). Mean follow-up time was 8.3 ± 5.7 years. The survival rate after discharge at 1, 5 and 10 years was 94%, 90% and 78%, respectively. Thirteen percent ( n  = 13) of patients underwent valve-related reoperation. Freedom from valve-related reoperation at 1, 5 and 10 years was 96%, 88% and 85%, respectively. Compared to patients who underwent the David I procedure for any reason other than AADA, there were no significant differences in long-term survival rates ( P  = 0.29) and freedom from a valve-related reoperation ( P  = 0.39). The valve-sparing David I procedure has acceptable long-term results even in emergent operations for AADA and is not inferior when performed in elective settings. © The Author 2017. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.

  4. Surgical management of gynecomastia: 20 years' experience

    NARCIS (Netherlands)

    Lapid, O.; Jolink, F.

    2014-01-01

    Gynecomastia, breast hypertrophy in men, is a common finding. The diagnosis is clinical, and ancillary tests may be performed; however, there is no unanimity in the literature about their use or utility. The mainstay of management is conservative, with a minority of patients being operated on. The

  5. Operational experience for the latest generation of ATRIUM trademark 10 fuel assemblies

    International Nuclear Information System (INIS)

    Schoss, Volker; Hoffmann, Petra Britt; Schaefer, Jens

    2011-01-01

    AREVA NP's ATRIUM trademark 10 product family was first introduced to the BWR market in 1992. Lead test campaigns confirmed the outstanding product performance and justified introduction of reload quantities. Further development of particular product features was demonstrated and implemented in the fuel design to meet highest expectations for reliability and fuel economics. The latest generation called ATRIUM trademark 10XP and subsequently ATRIUM trademark 10XM was introduced in 2002 and 2005, respectively. The first lead test assemblies completed their operation successfully after seven cycles. (orig.)

  6. Latest Results of Open Heavy Flavor and Quarkonia from the PHENIX Experiment at RHIC

    International Nuclear Information System (INIS)

    Nouicer, Rachid

    2017-01-01

    The PHENIX Collaboration carries out a comprehensive physics program which studies heavy flavor production in relativistic heavy ion collisions at RHIC. The discovery at RHIC of large high-p T suppression and flow of electrons from heavy quarks flavors have altered our view of the hot and dense matter formed in central Au+Au collisions at GeV. These results suggest a large energy loss and flow of heavy quarks in the hot, dense matter. In recent years, the PHENIX has installed a silicon vertex tracker both in central rapidity (VTX) and in forward rapidity (FVTX) regions, and has collected large data samples. These two silicon trackers enhance the capability of heavy flavor measurements via precision tracking. This paper summarizes some of the latest PHENIX results concerning open heavy flavor and quarkonia production as a function of rapidity, energy and system size. (paper)

  7. Analysis of Latest Experience in Design of Industrial Buildings Reconstruction by Constructing Additional Interfloor Overlaps

    Science.gov (United States)

    Peshnina, I.; Sinitsina, O.

    2017-11-01

    The study relevance is determined by the increasing interest in reconstruction of city historical centers and located in the area of industrial buildings the functional profile of which needs to be changed. The problem of obtaining extra usable spaces in the historical centers of cities is solved by raising the number of storeys in the buildings which can be achieved by the construction of additional built-in inter-floor overlaps. The article is dedicated to the analysis of the recent years’ experience in reconstruction design involving this method in our country and abroad, in the Netherlands, in particular. The article presents the results of the analysis of the experience in reconstruction of the objects by constructing additional inter-floor overlaps and aims to define the optimum construction solution for built-in inter-floor overlapping and to develop non-existing solutions for wide application of this method in the reconstruction of a building with non-unified and unmodulated parameters. It was determined as expedient to apply a monolith reinforced concrete slab with the use of steel profiled flooring as a formwork and reinforcement and steel beams designed as “Built-in Beams” for the construction of built-in inter-floor overlaps in reconstruction. The article will be useful for specialists doing research in the sphere of reconstruction of the buildings and for the practical activity of design engineers.

  8. Exploiting the information revolution: call for independent evaluation of the latest English national experiment.

    Science.gov (United States)

    Scott, Philip

    2015-02-19

    The English National Health Service (NHS) has a long history of national experiments with information technology; some successful, others less so. The NHS England Five Year Forward View aspires to 'Exploit the information revolution' through the transformational work of the National Information Board (NIB). NIB has published a 'Framework for Action' that promotes citizen empowerment, information availability, transparency, public trust, innovation, informatics skills and societal value. The framework sets out many laudable and common sense ambitions, but is light on evidence to support its aspirations, or plans for its evaluation. Considerable resource was invested in evaluation studies in the later stages of the National Programme for IT in England, but the analyses do not seem to have been included. Most of the cited evidence is from an unpublished report by management consultants rather than independent peer-reviewed work. National experiments of this importance should be evidence based and properly evaluated so that each iteration of 'information revolution' produces an evidence base to inform subsequent generations of care provision models and technology innovation. Evaluation should be planned from the very start rather than added in as an afterthought. Like any good business plan there should be defined critical success factors for health and social care, and a declaration of how they might be measured. Unintended consequences should be qualitatively explored. Evaluation should also consider critical-interpretive social perspectives to understand the human factors in technology deployment and should seek a theoretically informed insight into the mechanisms of change. The NHS Five Year Forward View and the NIB framework set out challenging ambitions based on transformative use of information technology and collaborative partnerships with commissioners and providers. The framework stands up very well against the Hayes principles, but the learning opportunities

  9. 20 years ago: first collisions (at LEP)

    CERN Multimedia

    2009-01-01

    It’s been 20 years since the first electron positron collision at LEP, and I have to confess to a little self-indulgence in my message this week. Back then I was a member of the OPAL collaboration, the first to see collisions at LEP just before midnight on 13 August 1989 and almost exactly one month after the first circulating beam. It was a historic moment, and the atmosphere in the OPAL control room, 100 metres underground, was one of anticipation and excitement. We reported back to the LEP control room, champagne duly arrived, and over the next few hours, all the experiments were recording data. The pilot run was as smooth as it could be, and within weeks we were announcing new physics. It’s interesting to contrast the start-up of LEP with that of the LHC. With the benefit of hindsight, LEP seems to have got going without a hitch, and indeed it was a smooth start. We circulated beam on 14 July, much to the joy of one of our host states, and it was just a month ...

  10. NDT in Canada - the next 20 years

    International Nuclear Information System (INIS)

    Kittmer, C.A.

    1985-01-01

    The theme for the Fifth Canadian Conference on Nondestructive Testing was 'NDT in Canada - The Next 20 years'. The three day conference with 42 presentations provided a short overview of NDT in Canada, a look at NDT in pipeline, materials, offshore, nuclear and training applications, and a glimpse into the next 20 years with recent advances in research and development as related to this 'hi-tech' field of work

  11. 20 years PSI accelerator. The speeches

    International Nuclear Information System (INIS)

    1994-01-01

    This publication contains the text of four papers presented at the occasion of the 20 year Symposium of the PSI accelerator. The papers dealt with the following topics: Scientific research and its dual interaction with industry and with the general public, the history of the PSI accelerator, μ-n-γ investigations on high temperature superconductors, therapy with charged particles. figs., tabs., refs

  12. 20 years' operation of the Rheinsberg nuclear power plant

    International Nuclear Information System (INIS)

    Lehmann, R.; Quasniczka, H.; Fiss, W.; Hentschel, G.; Schulz, K.D.

    1986-01-01

    After a 20 years' operation of the Rheinsberg nuclear power plant a review of the operating results achieved, performance of the main equipment, research and development works performed, and experience gained with education and training of plant staff is given. (author)

  13. The Psychiatry OSCE: a 20-year retrospective.

    Science.gov (United States)

    Hodges, Brian D; Hollenberg, Elisa; McNaughton, Nancy; Hanson, Mark D; Regehr, Glenn

    2014-02-01

    Twenty years ago researchers at the University of Toronto launched the Psychiatry Skills Assessment Project (PSAP), a research program exploring Objective Structured Clinical Examinations (OSCEs) in psychiatry. Between 1994 and 2005 PSAP produced publications on the feasibility, reliability, validity, ethics, and practical concerns of OSCEs in psychiatry. The current review has two parts: a review of the state of the art of OSCEs in psychiatry 20 years after they were introduced and documentation of the impact of the PSAP research program. A literature search identified all publications on OSCEs and psychiatry. Articles were coded thematically, and locations of agreement and controversies were identified. Bibliometric analysis identified citations of PSAP research papers, which were analyzed thematically. As of May 2013, there were 250 publications related to OSCEs in psychiatry (not including 10 PSAP papers), published in 29 different countries and ten languages. Prominent topics were the validity and acceptability of OSCEs and SPs, systems issues in adopting OSCEs in psychiatry, and the effects on learning. Eighty-eight percent of all publications cited PSAP work (300 citations). Citations were employed for four purposes: as evidence/justification (54 %); to frame replication research (14 %); to support adaptation of OSCEs in other countries and professions (15 %); and for debate (18 %). Over the past 20 years, use of OSCEs has grown steadily in psychiatry, and several national certification organizations have adopted OSCEs. PSAP work, introduced two decades ago, continues to provide a scholarly foundation for psychometric, practical, and ethical issues of interest to this field.

  14. 20 YEARS OF PROGRESS IN MALARIA RESEARCH

    Directory of Open Access Journals (Sweden)

    J. Kevin Baird

    2012-09-01

    Full Text Available U.S. Naval Medical Research Unit No. 2 Detachment (NAMRU, in collaboration with National Institute of Health Research and Development (NIHRD and many other Indonesian government agencies and universities, has conducted studies of malaria throughout Java, Sumatra, Sulawesi, Kalimantan, Flores, Timor, and Irian Jaya. Most studies have characterized the disease epidemiologically by defining the parasitologic distribution of the disease in the population, and by defining the entomologic parameters of local transmission. Studies of patterns of resistance to antimalarials have also been done at many field sites. Several studies on the clinical management of malaria occurred in Rumah Sakit Umum Propinsi in Jayapura. In addition to these studies which impact upon local public health planning policy, immunologic studies routinely occurred in support of the global effort to develop a vaccine against malaria. This report summarizes the progress made in these areas of research during the first 20 years of NAMRU in Indonesia.

  15. Planetary nebulae: 20 years of Hubble inquiry

    Science.gov (United States)

    Balick, Bruce

    2012-08-01

    The Hubble Space Telescope has served the critical roles of microscope and movie camera in the past 20 years of research on planetary nebulae (``PNe''). We have glimpsed the details of the evolving structures of neutral and ionized post-AGB objects, built ingenious heuristic models that mimic these structures, and constrained most of the relevant physical processes with careful observations and interpretation. We have searched for close physical binary stars with spatial resolution ~50 AU at 1 AU, located jets emerging from the nucleus at speeds up to 2000 km s-1 and matched newly discovered molecular and X-ray emission regions to physical substructures in order to better understand how stellar winds and ionizing radiation interact to form the lovely symmetries that are observed. Ultraviolet spectra of CNO in PNe help to uncover how stars process deep inside AGB stars with unstable nuclear burning zones. HST broadband imaging has been at the forefront of uncovering surprisingly complex wind morphologies produced at the tip of the AGB, and has led to an increasing realization of the potentially vital roles of close binary stars and emerging magnetic fields in shaping stellar winds.

  16. Video-assisted thoracoscopic surgery lobectomy at 20 years

    DEFF Research Database (Denmark)

    Yan, Tristan D; Cao, Christopher; D'Amico, Thomas A

    2014-01-01

    OBJECTIVE: Video-assisted thoracoscopic surgery (VATS) lobectomy has been gradually accepted as an alternative surgical approach to open thoracotomy for selected patients with non-small-cell lung cancer (NSCLC) over the past 20 years. The aim of this project was to standardize the perioperative....... No statistically significant differences in the responses between the two rounds of questioning were identified. Consensus was reached on 21 controversial points, outlining the current accepted definition of VATS lobectomy, its indications and contraindications, perioperative clinical management...... and recommendations for training and future research directions. CONCLUSION: The present Consensus Statement represents a collective agreement among 50 international experts to establish a standardized practice of VATS lobectomy for the thoracic surgical community after 20 years of clinical experience....

  17. Cytopathologist-performed and ultrasound-guided fine needle aspiration cytology enhances diagnostic accuracy and avoids pitfalls: An overview of 20 years of personal experience with a selection of didactic cases.

    Science.gov (United States)

    Paksoy, Nadir; Ozbek, Busra

    2018-01-01

    Over the last few decades, fine needle aspiration cytology (FNA) has emerged as a SAFE (Simple, Accurate, Fast, Economical) diagnostic tool based on the morphologic evaluation of cells. The first and most important step in obtaining accurate results from FNA is to procure sufficient and representative material from the lesion and to appropriately transfer this material to the laboratory. Unfortunately, the most important aspect of this task occurs beyond the control of the cytopathologist, a key reason for obtaining unsatisfactory results with FNA. There is growing interest in the field of cytology in "cytopathologist-performed ultrasound (US)-guided FNA," which has been reported to yield accurate results. The first author has been applying FNA in his own private cytopathology practice with a radiologist and under the guidance of US for more than 20 years. This study retrospectively reviews the utility of this practice. We present a selection of didactic examples under different headings that highlight the application of FNA by a cytopathologist, accompanied by US, under the guidance of a radiologist, in the form of an "outpatient FNA clinic." The use of this technique enhances diagnostic accuracy and prevents pitfalls. The highlights of each case are also outlined as "take-home messages."

  18. Uruguayan experience melanomauveal: results of 63 patients at 20 years follow-up; Experiencia uruguaya en melanoma uveal: resultados de 63 pacientes en 20 años de seguimiento

    Energy Technology Data Exchange (ETDEWEB)

    Krygier, G; Castillo, C; Della Valle, A; Ugartemendia, E; Sabini, G; Viola, A; Musé, I. [Hospital de Clínicas, Facultad de Medicina, Montevideo (Uruguay)

    2010-12-15

    Fulltext: Uveal melanoma is the most common malignant intraocular tumor in primitive adults (70%). It happens so often sporadic and uveal melanoma family comprises only 0.6% of patients. 63 patients assisted information was collected at six different institutions Montevideo, Uruguay, for a period of 20 years. The diagnosis was confirmed by pathology in 55/63 (87%) cases. Radical surgery (predominantly enucleation) was performed on 54/63 (86%) patients. other options treatment were orbital exenteration, radiotherapy and brachytherapy protons. 25/63 (40%) developed distant metastases, mainly in liver. The median age at diagnosis was 59 years old. The most common symptom was decreased visual acuity in 50/63 (77%). Three patients had extension extrascleral tumor and pigmented lesions presented. There was a correlation between mixed and epithelioid tumors with survival statistically significant (p <0.01) but there was no relationship between tumor diameter and survival (p = 0.06). Three clinical cases of familial uveal melanoma demonstrated that They involved the first generation of the same family (brothers), one of the which also had breast cancer 2 years before ocular tumor. a mutation in the BRCA2 gene was identified. The three brothers were enucleated and died with a median survival of 19 months due to distant metastases. Secundarismo liver was confirmed radiologically in 23/63 (36.5%) cases. The disease-free interval from diagnosis of ocular tumor metastasis was 40.5 months and the median survival for the disease metastasis was 4 months. Overall survival was 88 months (95% CI 75-100). This study illustrates the natural history of this entity by taking into account the behavior heterogeneous of it in our country, especially with outstanding fatal and family with uveal melanoma (three brothers), and commitment extrascleral as the first clinical fact present in three other cases.

  19. The latest results on top quark pair cross-section measurement at the LHC-ATLAS experiment

    CERN Document Server

    Yamauchi, Katsuya; The ATLAS collaboration

    2015-01-01

    The latest results on top quark pair production cross-section measurement in proton-proton collisions at $\\sqrt{s}$ = 7\\,TeV and $\\sqrt{s}$ = 8\\,TeV with the ATLAS detector are reported. The inclusive cross-section was measured with relative uncertainty of 4\\% using the final state of the top quark pair including an electron and a muon. The measurement of the differential cross-section as functions of various observables such as the transverse momentum and the rapidity of the top quark and the invariant mass of the top quark pair system are also reported. These results are compared with various generators such as {\\sc Powheg}, {\\sc Alpgen} and {\\sc MC@NLO} and various sets of parton distribution functions.

  20. Experience of Google's latest deep learning library, TensorFlow, in a large-scale WLCG cluster

    Energy Technology Data Exchange (ETDEWEB)

    Kawamura, Gen; Smith, Joshua Wyatt; Quadt, Arnulf [II. Physikalisches Institut, Georg-August-Universitaet Goettingen (Germany)

    2016-07-01

    The researchers at the Google Brain team released their second generation's Deep Learning library, TensorFlow, as an open-source package under the Apache 2.0 license in November, 2015. Google has already deployed the first generation's library using DistBlief in various systems such as Google Search, advertising systems, speech recognition systems, Google Images, Google Maps, Street View, Google Translate and many other latest products. In addition, many researchers in high energy physics have recently started to understand and use Deep Learning algorithms in their own research and analysis. We conceive a first use-case scenario of TensorFlow to create the Deep Learning models from high-dimensional inputs like physics analysis data in a large-scale WLCG computing cluster. TensorFlow carries out computations using a dataflow model and graph structure onto a wide variety of different hardware platforms and systems, such as many CPU architectures, GPUs and smartphone platforms. Having a single library that can distribute the computations to create a model to the various platforms and systems would significantly simplify the use of Deep Learning algorithms in high energy physics. We deploy TensorFlow with the Docker container environments and present the first use in our grid system.

  1. 20 years of the Lenin atomic icebreaker

    International Nuclear Information System (INIS)

    Lebedev, O.K.; Mel'nikov, Eh.M.; Mitenkov, F.M.; Movshevich, Z.M.; Pologikh, B.G.; Khlopkin, N.S.

    1980-01-01

    Operation experience of the ice-breaker ''Lenin'' which has provided a valuable material to advance marine nuclear power plants is analyzed. The application of electric motion to improve the ice-breaker manoeuvrability, simplification of reactor primary circuit to facilitate the equipment accessibility and maintenance, utilization of a water-vessel type reactor are among the achievements. Training of highly skilled specialists for the mearchant nuclear fleet is one of the main ice-breaker operation results. The long and intence operation of the nuclear ice-breaker ''Lenin'' has confirmed a high reliability of the steam-generating plant equipment and the whole plant

  2. 20 Years is not long enough.

    Science.gov (United States)

    Korol, Lucía

    2005-08-01

    The author presents some Latin American sociopolitical vicissitudes exemplified by Argentina, where she lives and where she trained and practices as a psychoanalyst. The exposition is based on the impact that her experience with two patients, Ana and Juana, had on her, and is presented in the form of clinical vignettes. The author reflects clinically and technically on the transference and countertransference and on the ways in which self-analysis enabled her to distinguish between the countertransference related to the patient and that related to the psychoanalyst. Finally, the author discusses the traumatic effects of 'the human condition', 'social violence' and 'Evil', referring specifically to the 'repetitive trauma' individuals experience under the globalization of terror and to the use of mechanisms of disavowal that result in serious splitting. The author confronts the reader with totalitarian terror as something that attacks and destroys the main constitutive characteristic of human beings, namely, their ability to think, remarking that H. Arendt is the one who speaks about 'radical evil' as 'the banality of Evil'. The author addresses the question of whether by tempering aggression and organizing levels of symbolization 'words' might prevent the emergence of 'pure jouissance' and be more powerful and significant than violence, overriding it.

  3. 20 years' experience in the management of Zenker's diverticulum in a third-level hospital Experiencia de 20 años en el manejo del divertículo de Zenker en un hospital de 3er nivel

    Directory of Open Access Journals (Sweden)

    J. Ruiz-Tovar

    2006-06-01

    Full Text Available Zenker's diverticulum arises in the posterior wall of the pharynx, above the cricopharyngeal muscle, secondary to a functional cricopharyngeal disorder. We describe our experience with the management of Zenker's diverticulum from 1985 to this day in a third-level hospital. We review clinical data from 27 patients (78% males with a mean age of 60.4 years. The most common clinical manifestations were dysphagia, regurgitation, syalorrhea, cough, and weight loss. All cases were diagnosed using an esophagogram. A diverticulectomy with cricopharingeal myotomy was performed in 74% of patients. Complications developed in 5 cases (21%, and the recurrence rate was 4% (1 of 3 cases, where myotomy was not performed.

  4. Latest results from LUNA

    Science.gov (United States)

    Depalo, Rosanna; LUNA Collaboration

    2018-01-01

    A precise knowledge of the cross section of nuclear fusion reactions is a crucial ingredient in understanding stellar evolution and nucleosynthesis. At stellar temperatures, fusion cross sections are extremely small and difficult to measure. Measuring nuclear cross sections at astrophysical energies is a challenge that triggered a huge amount of experimental work. A breakthrough in this direction was the first operation of an underground accelerator at the Laboratory for Underground Nuclear Astrophysics (LUNA) in Gran Sasso, Italy. The 1400 meters of rocks above the laboratory act as a natural shield against cosmic radiation, suppressing the background by orders of magnitude. The latest results achieved at LUNA are discussed, with special emphasis on the 22Ne(p,γ)23Na reaction. Future perspectives of the LUNA experiment are also illustrated.

  5. Picosecond spectroscopy: The first 20 years

    International Nuclear Information System (INIS)

    Rentzepis, P.M.

    1987-01-01

    Lasers were at first operating in the pulsed mode. That was the ruby, Cr/sup 3+/, emitting at 694.3 nm with a few kilowatts power, several microseconds time width, and a rather broad non-smooth-spiky-intensity profile. Even with such a primitive laser source, several noteworthy, novel experiments were performed such as two photon processes and second harmonic generation. The advent of Q-switch lasers by means of dyes, Kerr cells and electro-optic crystals introduced the era of high power lasers and laser spectroscopy. The high intensity and rather smooth intensity versus time profile pulses emitted by ruby and Nd/sup 3+//glass lasers provided excellent means for non-linear spectroscopy studies and nanosecond Raman spectroscopy, a field which flourished ten years later. In the mid-sixties, the He/Ne laser was mode locked, and shortly thereafter, the Nd/sup 3+//glass laser was also mode locked and shown to emit picosecond duration pulses. This paper presents what one observes on the screen of an oscilloscope once a laser is set up so as to generate picosecond pulses by use of either a saturable absorbing dye or solid state modulator. What is seen is, of course, a train of pulses. It is characteristic of these pulses that their intensity is extremely high, in the gigawatt region. In this particular case, the band width is approximately twenty to thirty wavenumbers. The method utilized to measure the picosecond pulses, initially, was the two photon method. This paper also gives a more graphic illustration how this technique operates. This same procedure provides an extremely simple technique which the author believes made possible the initial development of the picosecond spectroscopy field

  6. [Acquired immunodeficiency syndrome-related lymphoma: 1. Course during the 20 years of the epidemic. 2. The experience at the Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán: 1986-2003].

    Science.gov (United States)

    Hernández-Rivera, E Gabriela; Gómez-Roel, Xóchitl; Villasís-Keever, Angelina

    2004-01-01

    The goal of this presentation is the description of the epidemiologic evolution and changes in natural history of the human immunodeficiency virus infection (HIV) epidemic itself and its relation with the acquired immunodeficiency syndrome-related lymphoma (ARL). We have started with the description of the world's state of the HIV epidemic, its features since the first case report in the United States of America in 1981, through the peak of new diagnoses in 1993 until the event that changed the natural history of the disease: the era of the widespread use of the highly active antiretroviral therapy (HAART), introduced in 1995 in the world and in 1997 in our country. The widespread introduction of HAART led to dramatic reductions in AIDS related mortality and morbidity throughout the developed world with a marked fall in the incidence of the major opportunistic infections in AIDS. We describe the main risk factors for the development of ARL, and the prognostic factors for survival and response to treatment. There is no clear definition in the literature of the roll that has played the use of HAART in relation to survival and response to treatment in ARL, but there is evidence that the basal count of CD4 cells has increased with HAART, leading to a better survival and response in ARL. The debate regarding this issue is surely affected by factors such as degree of antiretroviral treatment compliance, antiretroviral therapy resistance and chemotherapy heterogeneity. Finally we present the preliminary results of the analysis of our experience in ARL from 1986 to 2003.

  7. Latest results from EXO-200

    International Nuclear Information System (INIS)

    TOSI, D.

    2014-01-01

    The Enriched Xenon Observatory (EXO) is an experimental program searching for neutrino-less double beta decay in xenon-136. The first stage of this program, EXO-200, has been in operation since early 2011. I present here the latest physics results from the experiment.

  8. The Biochemistry Over 20 Years In The High School Textbooks

    Directory of Open Access Journals (Sweden)

    C. E.S. Rocha

    2014-08-01

    Full Text Available   The Biochemistry Over 20 Years In The High School Textbooks   Rocha, C. E. S.1; Büttenbender, M. D.1; Denardin, E.L.G.2, Roehrs, R.1,2 1Grupo Interdisciplinar de Pesquisa em Práticas de Ensino, UNIPAMPA, RS. 2Laboratório de Estudos Físico Químicos e Produtos Naturais, UNIPAMPA, RS.   INTRODUCTION: Many teachers make use of textbook to lead content in the classroom. The chemistry books introduce concepts that should relate biochemistry to students in schools. It is important that this first contact turns out into an encouraging experience for the students, because once it worked as expected it arouses interest and makes the students see themselves curious to delve into the subject. The research aims to evaluate the presence of related concepts in biochemistry textbooks in chemistry in high school, over 20 years. MATERIAL AND METHODS: In order to perform this study, we analyzed the following content related to biochemistry: proteins, carbohydrates, lipids and nucleic acids in the books "Chemistry - Structure of Matter and Organic Chemistry" of the year 1993 and the book "Chemistry in approach to daily life" of the year 2012 with the purpose of verifying the changes in the content of biochemistry in the last 20 years. RESULTS AND DISCUSSION: In the 90s, as used in the book, concepts and explanations are introduced in a very objective approach, making a total of 22 pages. The current largest is 23 pages with experiments and curiosities. Through analysis we found that current textbooks present the same issues related to biochemistry, however, a greater amount of data, bringing students to more examples and applications in everyday life. Today we see that the contents and processes are most exploited and that there is a concern on the importance of the study of issues that relate to biochemistry. CONCLUSIONS: The study of the biochemistry textbooks has been more attractive in recent years, contextualizing content with the daily life of

  9. Research reactor FR2 - 20 years chemical and radiochemical measurements

    International Nuclear Information System (INIS)

    Feuerstein, H.; Graebner, H.; Oschinski, J.; Hoffmann, W.; Beyer, J.

    1986-09-01

    The FR2 has been a D 2 O cooled and moderated research reactor with a thermal output of 44 MW. It was in operation from 1961 to 1981. Because of the operating conditions of the reactor, only a small number of routine measurements were performed. For these however special techniques had to be developed. During the 20 years of operation a number of special events occured or have been observed, sometimes with very amazing results, e.g. the 'aceton effect'. This report describes the chemical and radiochemical conditions of the reactor systems, as well as the results of the surveilance work. Not described are measurements for the many experiments. The last chapter gives in a short form a description of the most unusual events and observations. (orig.) [de

  10. Smoke Inhalation and Cyanide Poisoning: 20 Years of Paris Experience

    International Nuclear Information System (INIS)

    Baud, F. J.

    2007-01-01

    Hydroxocobalamin has been used as a cyanide poisoning antidote for many years in France. It has recently been approved by the US FDA. In Paris, hydroxocobalamin is carried by the Brigade de Sapeurs Pompiers (Paris Fire Brigade) in mobile intensive care vehicles and has been administered empirically to victims of enclosed-space fire smoke inhalation who meet the criteria of having soot in the nose, mouth, or throat, any alteration in mental status or disturbance in consciousness, and especially if any degree of hypotension is present (BP less than or equal to 100 mmHg systolic). The administration of hydroxocobalamin at the scene was shown to be safe. Hydroxocobalamin has also been efficacious and safe in 'pure' cyanide poisoning, as long as brain death has not already occurred. A 'toxidrome' of cyanide poisoning has been developed in our institution in Paris, and its application can assist in making the diagnosis of this life-threatening poisoning which cannot be emergent diagnosed by currently-available laboratory methods.(author)

  11. Environmental monitoring of the Kozloduy NPP: 20 year experience

    Energy Technology Data Exchange (ETDEWEB)

    Aleksiev, A; Tsochev, S; Dimitrov, M; Avramov, V [Kombinat Atomna Energetika, Kozloduj (Bulgaria)

    1996-12-31

    The radiation monitoring system of the Kozloduy NPP is described and the assessment of the environmental impact of the power plant is presented. Measurements are carried out in 36 control points distributed in 3 areas: radiation protected area (3 km diameter), radiation controlled area (12 km) and surveillance area (100 km). Comparison of radiation monitoring data for 1993 with data recorded in the pre-operational period (1972-74) show that no significant changes can be detected in the activity of {sup 90} Sr and gross beta activity. An increase in Cs-137 activity (38 Bq/kg d.w. versus 7 Bq/kg d.w.) is found in the soil and bottom sediments in the Danube river, which is attributed to Chernobyl accident. The Kozloduy NPP operation is continuously monitored for release of artificial radionuclides by gaseous and liquid effluents. It is reported that the average population exposure in the 30 km area due to liquid effluents is 3-4.10{sup -4} man Sv/a. A system for automated continuous radiation monitoring in 10 control stations is available in case of radiation accidents. It is supplemented by a mobile laboratory. Meteorological measurements are carried out by automatic station MC-10 and a second station is under construction. 21 refs., 2 figs., 6 tabs.

  12. Acute Lymphoblastic Leukemia in Infants: 20 years of Experience

    Directory of Open Access Journals (Sweden)

    Amanda Ibagy

    2013-01-01

    Full Text Available Objective: To analyze patients younger than 2 years with acute lymphoblastic leukemia, treated in the period between 1990 and 2010 in a state reference center. Methods: This was a clinical-epidemiological, cross-sectional, observational, and descriptive study. It included patients younger than 2 years with acute lymphoblastic leukemia, treated in the period of 1990 to 2010 in a pediatric oncology unit of a state reference center, totaling 41 cases. Results: All patients were white ethnicity, and 60.9% were females. Regarding age, 24.38% were younger than 6 months, 17.07% were between 6 months and 1 year, and 58.53% were older than 1 year. The age of 6 months was statistically significant for the outcome of death. Predominant signs and symptoms were fever, bruising, and petechiae. A leukocyte count > 100,000 was found in 34.14% of cases, hemoglobin count < 11 in 95.13%, and platelet count < 100,000 in 75.61. Infiltration of central nervous system was present in 12.91% of patients. According to the lineage, B-cell lineage predominated (73%, but the T-cell line was statistically significant for death. 39% of patients had disease recurrence. In relation to vital status, 70.73% of the patients died; septic shock was the main cause. Conclusions: Acute lymphoblastic leukemia in infants has a high mortality rate, especially in children under 1 year and those with T-cell derived lineage. Resumo: Objetivo: Analisar pacientes com menos de dois anos de idade com leucemia linfoblásti- ca aguda atendidos no período de 1990 a 2010, em um centro de referência estadual. Métodos: Estudo clínico, epidemiológico, transversal, descritivo e observacional. Pacientes incluídos tinham menos de dois anos de idade, com leucemia linfoblástica aguda, tratados no período de 1990 a 2010 na unidade de oncologia pediátrica de um centro de referência estadual, totalizando 41 casos. Resultados: Todos os pacientes eram Caucasianos e 60,9% eram do sexo feminino. Com relação à idade, 24,38% tinham menos de seis meses, 17,07% tinham entre seis meses e um ano e 58,53% mais do que um ano de idade. A idade de seis meses foi estatisticamente significante para o desfecho de óbito. Os sinais e sintomas predominantes foram febre, hematomas e petéquias. Uma contagem de leucócitos superior a 100.000 foi observada em 34,14% dos casos; hemoglobina inferior a 11 em 95,13% e contagem de plaquetas inferior a 100.000, em 75,61% dos casos. Infiltração do sistema nervoso central estava presente em 12,91% dos pacientes. Em relação à linhagem, a linhagem B predominou (73%, mas a linhagem de células T foi estatisticamente significativa para o óbito. Trinta e nove por cento dos pacientes tiveram recorrência da doença. Em relação ao estado vital, 70,73% dos pacientes morreram, sendo choque séptico a principal causa. Conclusões: : leucemia linfoblástica aguda em crianças tem uma alta taxa de mortalidade, principalmente em crianças menores de um ano e linhagem derivada de células T. Keywords: Infant, Leukemia, classification, Precursor cell lymphoblastic leukemia-lymphoma, Palavras-chave: Crianças, Leucemia, classificação, Leucemia-linfoma linfoblástica precursora de células

  13. Environmental monitoring of the Kozloduy NPP: 20 year experience

    International Nuclear Information System (INIS)

    Aleksiev, A.; Tsochev, S.; Dimitrov, M.; Avramov, V.

    1995-01-01

    The radiation monitoring system of the Kozloduy NPP is described and the assessment of the environmental impact of the power plant is presented. Measurements are carried out in 36 control points distributed in 3 areas: radiation protected area (3 km diameter), radiation controlled area (12 km) and surveillance area (100 km). Comparison of radiation monitoring data for 1993 with data recorded in the pre-operational period (1972-74) show that no significant changes can be detected in the activity of 90 Sr and gross beta activity. An increase in Cs-137 activity (38 Bq/kg d.w. versus 7 Bq/kg d.w.) is found in the soil and bottom sediments in the Danube river, which is attributed to Chernobyl accident. The Kozloduy NPP operation is continuously monitored for release of artificial radionuclides by gaseous and liquid effluents. It is reported that the average population exposure in the 30 km area due to liquid effluents is 3-4.10 -4 man Sv/a. A system for automated continuous radiation monitoring in 10 control stations is available in case of radiation accidents. It is supplemented by a mobile laboratory. Meteorological measurements are carried out by automatic station MC-10 and a second station is under construction. 21 refs., 2 figs., 6 tabs

  14. Sperm banking for fertility preservation: a 20-year experience.

    Science.gov (United States)

    Johnson, Matrika D; Cooper, Amber R; Jungheim, Emily S; Lanzendorf, Susan E; Odem, Randall R; Ratts, Valerie S

    2013-09-01

    Sperm banking is an effective method to preserve fertility, but is not universally offered to males facing gonadotoxic treatment in the United States. We compared the disposition and semen parameters of cryopreserved sperm from individuals referred for sperm banking secondary to a cancer diagnosis to those of sperm from men banking for infertility reasons. We performed a retrospective cohort study that reviewed 1118 records from males who presented to bank sperm at Washington University between 1991 and 2010. We collected and analyzed demographics, semen parameters, and disposition of banked sperm. Four hundred and twenty-three men with cancer and 348 banking for infertility reasons attempted sperm cryopreservation in our unit during the specified time period. The most prevalent cancers in our cohort were testicular (32%), lymphoma (25%), and leukemia (11%). Patients with leukemia had the lowest pre-thaw counts and motility. Most cancer patients (57%) who banked elected to use, transfer to another facility, or keep their specimens in storage. The remaining samples were discarded electively (34%) or following death (8%). Overall semen parameters were similar between the cancer and infertility groups, but demographics, ability to bank a sample, azoospermia rates, length of storage, current banking status, and use of banked sperm differed significantly between the two groups. The majority of cancer patients who banked survived their cancer and chose to continue storage of banked samples. Cancer patients were more likely than infertility patients to use or continue storage of banked samples. Our study provides evidence that sperm banking is a utilized modality of fertility preservation in patients with a myriad of cancer diagnoses and should be offered to all men facing gonadotoxic therapies. Further work is needed to determine where disparities in access to sperm banking exist to improve the potential for future fertility in these males. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  15. Juvenile nasopharyngeal angiofibroma in a 20 year old Nigerian male

    African Journals Online (AJOL)

    This paper presents misdiagnosis of a 20 year old male with Juvenile nasopharyngeal angiofibroma (JNA). Methods: The case record of a 20year old male who presented with recurrent spontaneous profuse epistaxis, progressive nasal obstruction, hyponasality and conductive hearing loss with mass in the post nasal space ...

  16. Radiation protection issues after 20 years of LHC operation

    CERN Document Server

    Forkel-Wirth, D.; Roesler, S.; Theis, C.; Ulrici, L.; Vincke, H.; Vincke, Hz.

    2011-01-01

    Since November 2009, the LHC commissioning progresses very well, both with proton and lead beams. It will continue in 2011 and nominal LHC operation is expected to be attained in 2013. In parallel, plans for various LHC upgrades are under discussion, suggesting a High-Luminosity (HL) upgrade first and a High-Energy (HE) upgrade in a later state. Whereas the upgrade in luminosity would require the modification of only some few key accelerator components like the inner triplets, the upgrade in beam energy from 7 TeV to 16.5 TeV would require the exchange of all dipoles and of numerous other accelerator components. The paper gives an overview of the radiation protection issues related to the dismantling of LHC components prior to the installation of the HE-LHC components, i.e. after about 20 years of LHC operation. Two main topics will be discussed: (i) the exposure of workers to ionizing radiation during the dismantling of dipoles, inner triplets or collimators and experiments and (ii) the production, condition...

  17. Psychiatric disorders revealing multiple sclerosis after 20 years of evolvement

    Directory of Open Access Journals (Sweden)

    Aicha Slassi Sennou

    2014-01-01

    Full Text Available Previous research indicates that the onset of psychiatric disorders is sometimes associated with multiple sclerosis (MS evolving several years later. However, information on why this might occur, and on the outcomes of such patients, is still lacking. We aim to discuss these limitations with the current paper. We describe a 51-year-old female who demonstrated severe anxiety disorder and depression years before developing MS neurological symptoms. The patient was treated for these psychiatric disorders over 20 years. In the last 3 years of her treatment, the patient demonstrated a choreic-type of movement disorder in all her limbs. This disorder is consistent with relapsing-remitting MS. Clinical and magnetic resonance imaging (MRI examinations demonstrated aspects of MS, without MS being diagnosed conclusively. The visual evoked potential indicated a diagnosis of conduction abnormalities. The established diagnosis was slow relapsing MS. The patient underwent methylprednisolone bolus (1 g/day. This case-study suggests that health professionals should conduct a full neurological assessment when they find atypical psychiatric symptoms in a patient. This would make sure that patients receive a better standard of care, and thus experience a better quality of life.

  18. The Latest Forecast.

    Science.gov (United States)

    Laurence, David

    2002-01-01

    Discusses the "latest forecast" for the future of English departments. Addresses departmental and institutional staffing practices, employment opportunities for PhDs, the acceleration of change in the institution, and the general state of the study and teaching of English. (RS)

  19. Cancer consequences of the Chernobyl accident: 20 years on

    International Nuclear Information System (INIS)

    Cardis, Elisabeth; Howe, Geoffrey; Ron, Elaine

    2006-01-01

    26 April 2006 marks the 20th anniversary of the Chernobyl accident. On this occasion, the World Health Organization (WHO), within the UN Chernobyl Forum initiative, convened an Expert Group to evaluate the health impacts of Chernobyl. This paper summarises the findings relating to cancer. A dramatic increase in the incidence of thyroid cancer has been observed among those exposed to radioactive iodines in childhood and adolescence in the most contaminated territories. Iodine deficiency may have increased the risk of developing thyroid cancer following exposure to radioactive iodines, while prolonged stable iodine supplementation in the years after exposure may reduce this risk. Although increases in rates of other cancers have been reported, much of these increases appear to be due to other factors, including improvements in registration, reporting and diagnosis. Studies are few, however, and have methodological limitations. Further, because most radiation-related solid cancers continue to occur decades after exposure and because only 20 years have passed since the accident, it is too early to evaluate the full radiological impact of the accident. Apart from the large increase in thyroid cancer incidence in young people, there are at present no clearly demonstrated radiation-related increases in cancer risk. This should not, however, be interpreted to mean that no increase has in fact occurred: based on the experience of other populations exposed to ionising radiation, a small increase in the relative risk of cancer is expected, even at the low to moderate doses received. Although it is expected that epidemiological studies will have difficulty identifying such a risk, it may nevertheless translate into a substantial number of radiation-related cancer cases in the future, given the very large number of individuals exposed. (review)

  20. Cancer consequences of the Chernobyl accident: 20 years on

    Energy Technology Data Exchange (ETDEWEB)

    Cardis, Elisabeth [International Agency for Research on Cancer, 150 Cours Albert Thomas, 69372 Lyon CEDEX 08 (France); Howe, Geoffrey [Department of Epidemiology, Mailman School of Public Health, Columbia University, 722 W. 168th Street, Room 1104, New York, NY 10032 (United States); Ron, Elaine [Radiation Epidemiology Branch, Division of Epidemiology and Genetics, National Cancer Institute, Building EPS, MS 7238, Rockville, MD 20852 (United States)] (and others)

    2006-06-15

    26 April 2006 marks the 20th anniversary of the Chernobyl accident. On this occasion, the World Health Organization (WHO), within the UN Chernobyl Forum initiative, convened an Expert Group to evaluate the health impacts of Chernobyl. This paper summarises the findings relating to cancer. A dramatic increase in the incidence of thyroid cancer has been observed among those exposed to radioactive iodines in childhood and adolescence in the most contaminated territories. Iodine deficiency may have increased the risk of developing thyroid cancer following exposure to radioactive iodines, while prolonged stable iodine supplementation in the years after exposure may reduce this risk. Although increases in rates of other cancers have been reported, much of these increases appear to be due to other factors, including improvements in registration, reporting and diagnosis. Studies are few, however, and have methodological limitations. Further, because most radiation-related solid cancers continue to occur decades after exposure and because only 20 years have passed since the accident, it is too early to evaluate the full radiological impact of the accident. Apart from the large increase in thyroid cancer incidence in young people, there are at present no clearly demonstrated radiation-related increases in cancer risk. This should not, however, be interpreted to mean that no increase has in fact occurred: based on the experience of other populations exposed to ionising radiation, a small increase in the relative risk of cancer is expected, even at the low to moderate doses received. Although it is expected that epidemiological studies will have difficulty identifying such a risk, it may nevertheless translate into a substantial number of radiation-related cancer cases in the future, given the very large number of individuals exposed. (rev0009i.

  1. Are History Textbooks More "Considerate" after 20 Years?

    Science.gov (United States)

    Berkeley, Sheri; King-Sears, Margaret E.; Hott, Brittany L.; Bradley-Black, Katherine

    2014-01-01

    Features of eighth-grade history textbooks were examined through replication of a 20-year-old study that investigated "considerateness" of textbooks. Considerate texts provide clear, coherent information and include features that promote students' comprehension, such as explicit use of organizational structures, a range of question types…

  2. Kaposi sarcoma appearing 20 year post renal transplant | Yassir ...

    African Journals Online (AJOL)

    A kidney- transplanted Saudi patient presented with a skin rash for which he was treated as fungal infection .The patient developed these lesions 20 years after transplantation. The clinical picture was that of Kaposi\\'s sarcoma which was confirmed by histopathology .The patient developed these lesions after he was shifted ...

  3. The latest radiation instrument

    International Nuclear Information System (INIS)

    Kang, Se Sik; Gwon, Dal Gwan; Kim, Gyeong Geum

    2008-08-01

    This book deals with the latest radiation instrument, which is comprised of eight chapters. It explains X rays instrument for medial treatment, X-ray tube instrument and permissible burden with its history, structure and characteristic high voltage apparatus with high voltage rectifier circuit, X-ray control apparatus for medical treatment, X-ray image equipment X-ray television apparatus and CCD 205, X-ray apparatus of install and types, Digital X-ray apparatus with CR 261 and DR 269, performance management on X-ray for medical treatment with its history, necessity and management in the radiation field.

  4. The latest general chemistry

    International Nuclear Information System (INIS)

    Ryu, Geun Bae; Choi, Se Yeong; Kim, Chin Yeong; Yoon, Gil Jung; Lee, Eun Seok; Seo, Moon Gyu

    1995-02-01

    This book deals with the latest general chemistry, which is comprised of twenty-three chapters, the contents of this book are introduction, theory of atoms and molecule, chemical formula and a chemical reaction formula, structure of atoms, nature of atoms and the periodic table, structure of molecule and spectrum, gas, solution, solid, chemical combination, chemical reaction speed, chemical equilibrium, thermal chemistry, oxidation-reduction, electrochemistry, acid-base, complex, aquatic chemistry, air chemistry, nuclear chemistry, metal and nonmetal, organic chemistry and biochemistry. It has exercise in the end of each chapter.

  5. [False aneurysm on dacron prosthesis, 20 years after aortofemoral bypass].

    Science.gov (United States)

    Illuminati, G; Bertagni, A; Nasti, A G; Montesano, G

    2001-10-01

    A 85-year-old male developed a false, non septic, non anastomotic aneurysm, 20 years after right aorto-femoral Dacron grafting for claudication. On account of the proximity to the femoral anastomosis, and the association with a profunda femoris stenosis, a conventional surgical repair was preferred to an endovascular treatment. The patient underwent a successful aneurysm resection followed by PTFE interposition between the primary graft and the profunda femoris artery, with uneventful recovery.

  6. Clinical observations over 20 years period of Bikini victims

    International Nuclear Information System (INIS)

    Kumatori, Toshiyuki

    1976-01-01

    The author outlined the results of medical examinations performed in a period of 20 years on the Japanese fishermen who were exposed at Bikini in 1954. Exposure doses were estimated, and the progress of medical examinations for skin injury, hematological changes, cytogenetic changes, and spermatogenetic disturbance was described. In view of internal exposure, none of the long half-life nuclides was retained in the body. The victims were compared with the victims exposed in Marshall Islands. (Serizawa, K.)

  7. Coartação de aorta em crianças até um ano: análise de 20 anos de experiência Coarctation of the aorta in infants under one year of age: an analysis of 20 years of experience

    Directory of Open Access Journals (Sweden)

    Gabriel Lorier

    2005-07-01

    Full Text Available OBJETIVO: Revisão da experiência com diversas técnicas de correção empregadas, nos últimos 20 anos, em crianças menores de um ano de idade. MÉTODOS: No período de 1978 a 1998, foram operados 148 pacientes (pc consecutivos com coartação de aorta (CoAo com até um ano de idade, com ou sem defeitos intracardíacos associados. A idade apresentou mediana de 50 dias, 92 pc do sexo feminino (62,1%. O peso foi de 4.367±1.897 gramas. O seguimento foi em média de 1.152±1.462 dias. A população foi dividida em 3 grupos: Grupo I, CoAo isolada: 74 pc (50%; Grupo II, CoAo e comunicação interventricular (CIV: 41 pacientes (27,7% e Grupo III, CoAo com malformações complexas: 33 pc (22,3%. RESULTADOS: Mortalidade total foi 43 pc (29%: com menos de 30 dias, foi 53%, p=0,009, OR=4,5, entre 31 e 90 dias, foi 14,7%, p=0,69, e acima de 91 dias, 15%, p=0,004. A probabilidade de sobrevida atuarial de toda a população foi de 67% aos 5 e 10 anos. Trinta e seis pacientes (24,3% recoartaram, dos quais 18 pacientes (50% tinham menos de 30 dias, OR=6,35. A incidência de recoartação foi com a técnica de Waldhausen em 4 pacientes (10% e com a término-terminal clássica em 19 pacientes (26% p=0.03, e a istmoplastia em 6 pacientes (37,5%. A probabilidade de sobrevida atuarial livre de recoartação aos 5 e 10 anos foi de 69% com a técnica de Waldhausen e 63% com a técnica término-terminal clássica. CONCLUSÃO: Pacientes com menos de 30 dias apresentaram risco aumentado de mortalidade e recoartação. A técnica de Waldhausen em pacientes com mais de 30 dias mostrou-se efetiva. A técnica término-terminal clássica mostrou não ser uma boa opção em todas as faixas etárias, sendo imperativo executar variantes técnicas como término-terminal estendida.OBJECTIVE: A review of experience with techniques of correction used, in the last 20 years, in children younger than one year old. METHODS: In the period from 1978 to 1998, 148 patients (pt with

  8. Keywords Review of IT Security Literature in Recent 20 Years

    OpenAIRE

    WANG Lidong; LIN Yan; QIAN Liping

    2012-01-01

    The volume of published scientific literature available on Internet has been increasing exponentially. Some of them reflect the latest achievement of the specific research domain. In recent years, many projects have been funded aiming to online scientific literature mining, especially in biomedical research. Scientific literature covers most of the hot topics in the research field and has a very large domain-specific vocabulary. The exploitation of domain knowledge and specialized vocabulary ...

  9. 20 Years of Dukovany NPP Operation and Plans for Future

    International Nuclear Information System (INIS)

    Vlcek, J.

    2006-01-01

    NPP Dukovany (4x440MW), the first Czech nuclear power plant and a keystone of Czech Electricity Grid, in 2005 celebrated 20 years of successful operation. In my presentation I am going to speak about next areas. I will start about construction and commissioning history of Dukovany NPP, then I'll put forward what milestones of Dukovany NPP operation were accomplished, I'll say examples about our modernisation and investment activities (including replacement of IandC equipment, modifications for increasing of power and support grid services) and in the end our plans for future. (author)

  10. Conceptualizing 20 years of engaged scholarship: A scoping review.

    Directory of Open Access Journals (Sweden)

    Marianne Beaulieu

    Full Text Available Engaged scholarship, a movement that has been growing steadily since 1995, offers a new way of bridging gaps between the university and civil society. Numerous papers and reports have been published since Boyer's foundational discourse in 1996. Yet, beyond a growing interest in orienting universities' missions, we observed a lack a formal definition and conceptualization of this movement. Based on a scoping review of the literature over the past 20 years, the objective of this article is to propose a conceptualization of engaged scholarship. More specifically, we define its values, principles, and processes. We conclude with a discussion of the implications of this new posture for faculty and students, as well as for the university as an institution.

  11. Conceptualizing 20 years of engaged scholarship: A scoping review

    Science.gov (United States)

    Beaulieu, Marianne; Breton, Mylaine

    2018-01-01

    Engaged scholarship, a movement that has been growing steadily since 1995, offers a new way of bridging gaps between the university and civil society. Numerous papers and reports have been published since Boyer’s foundational discourse in 1996. Yet, beyond a growing interest in orienting universities’ missions, we observed a lack a formal definition and conceptualization of this movement. Based on a scoping review of the literature over the past 20 years, the objective of this article is to propose a conceptualization of engaged scholarship. More specifically, we define its values, principles, and processes. We conclude with a discussion of the implications of this new posture for faculty and students, as well as for the university as an institution. PMID:29489870

  12. Residential Transitions among Adults with Intellectual Disability across 20 Years

    Science.gov (United States)

    Woodman, Ashley C.; Mailick, Marsha R.; Anderson, Kristy A.; Esbensen, Anna J.

    2014-01-01

    The present study addresses critical gaps in the literature by examining residential transitions among 303 adults with intellectual disability over 10 years (Part 1) and 75 adults with Down syndrome over 20 years (Part 2). All adults lived at home at the start of the study, but many moved to a variety of settings. Several characteristics of the adults with intellectual disability differed across settings, most notably adaptive behavior and the number of residential transitions, while characteristics such as age, type of disability, and behavior problems were less predictive of residential placements. The number of moves over the course of the study varied widely, with critical links to earlier family dynamics, social relationships, and health and adaptive behavior. PMID:25354121

  13. Conceptualizing 20 years of engaged scholarship: A scoping review.

    Science.gov (United States)

    Beaulieu, Marianne; Breton, Mylaine; Brousselle, Astrid

    2018-01-01

    Engaged scholarship, a movement that has been growing steadily since 1995, offers a new way of bridging gaps between the university and civil society. Numerous papers and reports have been published since Boyer's foundational discourse in 1996. Yet, beyond a growing interest in orienting universities' missions, we observed a lack a formal definition and conceptualization of this movement. Based on a scoping review of the literature over the past 20 years, the objective of this article is to propose a conceptualization of engaged scholarship. More specifically, we define its values, principles, and processes. We conclude with a discussion of the implications of this new posture for faculty and students, as well as for the university as an institution.

  14. Wind turbines - facts from 20 years of technological progress

    Energy Technology Data Exchange (ETDEWEB)

    Hansen, L H; Dannemand Andersen, P [Risoe Ntaional Lab., Roskilde (Denmark)

    1999-03-01

    The first Danish commercial wind turbines were installed in the late 1970s. Over the last 20 years the Danish wind turbine market has been relatively stable concerning annual installations, and the wind turbine technology has been able to develop continuously. This gives a unique time track for technology analysts. The aim of this paper is to extract reliable information on this time track from existing archives and statistics. Seven generations of wind turbine technology have been identified mainly based on `characteristic` rotor diameters. The technological development of each generation is described using indicators such as: market share in Denmark, generator size, rotor diameter, hub height, electricity production and productivity. Economical indicators comprise: costs of turbine and standard foundation. (au)

  15. The Role of Lifestyle Behaviors on 20-Year Cognitive Decline

    Directory of Open Access Journals (Sweden)

    D. Cadar

    2012-01-01

    Full Text Available This study examined the association between smoking, physical activity and dietary choice at 36 and 43 years, and change in these lifestyle behaviors between these ages, and decline in verbal memory and visual search speed between 43 and 60–64 years in 1018 participants from MRC National Survey of Health and Development (NSHD, the British 1946 birth cohort. ANCOVA models were adjusted for sex, social class of origin, childhood cognition, educational attainment, adult social class, and depression; then the lifestyle behaviors were additionally mutually adjusted. Results showed that healthy dietary choice and physical activity were associated, respectively, with slower memory and visual search speed decline over 20 years, with evidence that increasing physical activity was important. Adopting positive health behaviors from early midlife may be beneficial in reducing the rate of cognitive decline and ultimately reducing the risk of dementia.

  16. Wind turbines - facts from 20 years of technological progress

    International Nuclear Information System (INIS)

    Hansen, L.H.; Dannemand Andersen, P.

    1999-01-01

    The first Danish commercial wind turbines were installed in the late 1970s. Over the last 20 years the Danish wind turbine market has been relatively stable concerning annual installations, and the wind turbine technology has been able to develop continuously. This gives a unique time track for technology analysts. The aim of this paper is to extract reliable information on this time track from existing archives and statistics. Seven generations of wind turbine technology have been identified mainly based on 'characteristic' rotor diameters. The technological development of each generation is described using indicators such as: market share in Denmark, generator size, rotor diameter, hub height, electricity production and productivity. Economical indicators comprise: costs of turbine and standard foundation. (au)

  17. African Savanna-Forest Boundary Dynamics: A 20-Year Study

    Science.gov (United States)

    Cuni-Sanchez, Aida; White, Lee J. T.; Calders, Kim; Jeffery, Kathryn J.; Abernethy, Katharine; Burt, Andrew; Disney, Mathias; Gilpin, Martin; Gomez-Dans, Jose L.; Lewis, Simon L.

    2016-01-01

    Recent studies show widespread encroachment of forest into savannas with important consequences for the global carbon cycle and land-atmosphere interactions. However, little research has focused on in situ measurements of the successional sequence of savanna to forest in Africa. Using long-term inventory plots we quantify changes in vegetation structure, above-ground biomass (AGB) and biodiversity of trees ≥10 cm diameter over 20 years for five vegetation types: savanna; colonising forest (F1), monodominant Okoume forest (F2); young Marantaceae forest (F3); and mixed Marantaceae forest (F4) in Lopé National Park, central Gabon, plus novel 3D terrestrial laser scanning (TLS) measurements to assess forest structure differences. Over 20 years no plot changed to a new stage in the putative succession, but F1 forests strongly moved towards the structure, AGB and diversity of F2 forests. Overall, savanna plots showed no detectable change in structure, AGB or diversity using this method, with zero trees ≥10 cm diameter in 1993 and 2013. F1 and F2 forests increased in AGB, mainly as a result of adding recruited stems (F1) and increased Basal Area (F2), whereas F3 and F4 forests did not change substantially in structure, AGB or diversity. Critically, the stability of the F3 stage implies that this stage may be maintained for long periods. Soil carbon was low, and did not show a successional gradient as for AGB and diversity. TLS vertical plant profiles showed distinctive differences amongst the vegetation types, indicating that this technique can improve ecological understanding. We highlight two points: (i) as forest colonises, changes in biodiversity are much slower than changes in forest structure or AGB; and (ii) all forest types store substantial quantities of carbon. Multi-decadal monitoring is likely to be required to assess the speed of transition between vegetation types. PMID:27336632

  18. 20 year long term air quality trends in Israel

    Science.gov (United States)

    Luria, M.

    2017-12-01

    The Israeli air monitoring network was established in the mid 1990's with dozens of measuring sites near most populated areas. During these past 20 years the Israel economy has increased significantly. The population grew by 30%, energy consumption and power generation by more than 40% and the number of motor vehicles increased by nearly 50%. Most of the fossil energy is consumed by the electric power industry that has changed immensely during this period. Until the early 2000's the vast majority of the electricity was generated from coal and heavy oil. However, during the last ten years natural gas has gradually becomes the major source for power generation and for most of the heavy industry. In the present study we examined the impact of these economic trends on the major criteria air pollution parameters; O3, NOx, SO2 and PM10. The analyses was based on the long term trend of median value (50th percentile) and the 90th percentile. The results revealed that SO2 levels throughout the country decreased to very low levels, with the 90th percentile near the detection limit. The levels of PM10, that are relatively high compare with other global regions, did not show any trend during the 20 year period. This is consistent with the fact that most particulate matter results from long range transport of dust from the surrounding deserts. The long term trend of NOx indicates a gradual and steady increase at most measuring sites, which is consistent with the increase of fossil fuel consumption. The increase in NOx levels is most likely the cause for the significant increase in O3 levels found at most sites in a few of them to levels that are considered as an environmental hazard.

  19. A 20-year simulated climatology of global dust aerosol deposition.

    Science.gov (United States)

    Zheng, Yu; Zhao, Tianliang; Che, Huizheng; Liu, Yu; Han, Yongxiang; Liu, Chong; Xiong, Jie; Liu, Jianhui; Zhou, Yike

    2016-07-01

    Based on a 20-year (1991-2010) simulation of dust aerosol deposition with the global climate model CAM5.1 (Community Atmosphere Model, version 5.1), the spatial and temporal variations of dust aerosol deposition were analyzed using climate statistical methods. The results indicated that the annual amount of global dust aerosol deposition was approximately 1161±31Mt, with a decreasing trend, and its interannual variation range of 2.70% over 1991-2010. The 20-year average ratio of global dust dry to wet depositions was 1.12, with interannual variation of 2.24%, showing the quantity of dry deposition of dust aerosol was greater than dust wet deposition. High dry deposition was centered over continental deserts and surrounding regions, while wet deposition was a dominant deposition process over the North Atlantic, North Pacific and northern Indian Ocean. Furthermore, both dry and wet deposition presented a zonal distribution. To examine the regional changes of dust aerosol deposition on land and sea areas, we chose the North Atlantic, Eurasia, northern Indian Ocean, North Pacific and Australia to analyze the interannual and seasonal variations of dust deposition and dry-to-wet deposition ratio. The deposition amounts of each region showed interannual fluctuations with the largest variation range at around 26.96% in the northern Indian Ocean area, followed by the North Pacific (16.47%), Australia (9.76%), North Atlantic (9.43%) and Eurasia (6.03%). The northern Indian Ocean also had the greatest amplitude of interannual variation in dry-to-wet deposition ratio, at 22.41%, followed by the North Atlantic (9.69%), Australia (6.82%), North Pacific (6.31%) and Eurasia (4.36%). Dust aerosol presented a seasonal cycle, with typically strong deposition in spring and summer and weak deposition in autumn and winter. The dust deposition over the northern Indian Ocean exhibited the greatest seasonal change range at about 118.00%, while the North Atlantic showed the lowest seasonal

  20. 20 Years Health Promotion Research in and on settings

    Directory of Open Access Journals (Sweden)

    Heiko Waller

    2007-12-01

    Full Text Available In 2006 we celebrated the 20th anniversary of the Ottawa Charta for Health Promotion. During these 20 years health promotion became a very influential public health strategy. Let us - with reference to the WHO Health Promotion Glossary - recall some of the core elements of health promotion: “Health promotion represents a comprehensive social and political process, it not only embraces actions directed at strengthening skills and capabilities of individuals, but also actions directed towards changing social, environmental and economic conditions so as to alleviate their impact on public and individual health.Health promotion is the process of enabling people to increase control over the determinants of health and thereby improve their health. Participation is essential to sustain health promotion action.” The Ottawa Charter identifies three basic strategies for health promotion. These are (1 advocacy for health to create the essential conditions for health indicated above; (2 enabling all people to achieve their full health potential; and (3 mediating between different interests in society in the pursuit of health. The Ottawa Charter identifies three basic strategies for health promotion. These are (1 advocacy for health to create the essential conditions for health indicated above; (2 enabling all people to achieve their full health potential; and (3 mediating between different interests in society in the pursuit of health.

  1. Nuclear Poland? The second approach after 20 years

    Energy Technology Data Exchange (ETDEWEB)

    Sawicki, L.; Gołębiewski, T.; Fornalski, K.W.; Gadja, D.

    2015-07-01

    Poland’s plan for reorganization of its energy mix is to construct several nuclear reactors (2 NPPs with number of units depending on reactor type) of total capacity 6000 MW. It is assumed that energy from NPPs will provide up to 19% of the electricity production in Poland after 2035. Currently there is no nuclear power plant in operation. The previous nuclear programme was canceled in 1990. Almost 20 years later Polish government has undertaken second attempt to construct first NPP by adoption of The Polish Nuclear Power Program in January 2014. Since that moment were started intensive preparations to implement many legal regulations related to future nuclear industry in Poland e.g. Atomic Law amendment. In the same year the Owner’s Engineer was chosen by the main investor PGE S.A. Following “nuclear” a lot of Polish Universities launched studies connected with the subject to ensure employees for deployment and sustaining of nuclear technologies in Poland. This paper describes the rationale staying behind the government decision, present situation of Polish energy market and current work status. (Author)

  2. Environmental Volunteering and Health Outcomes over a 20-Year Period

    Science.gov (United States)

    Pillemer, Karl; Fuller-Rowell, Thomas E.; Reid, M. C.; Wells, Nancy M.

    2010-01-01

    Purpose: This study tested the hypothesis that volunteering in environmental organizations in midlife is associated with greater physical activity and improved mental and physical health over a 20-year period.  Design and Methods: The study used data from two waves (1974 and 1994) of the Alameda County Study, a longitudinal study of health and mortality that has followed a cohort of 6,928 adults since 1965. Using logistic and multiple regression models, we examined the prospective association between environmental and other volunteerism and three outcomes (physical activity, self-reported health, and depression), with 1974 volunteerism predicting 1994 outcomes, controlling for a number of relevant covariates.  Results: Midlife environmental volunteering was significantly associated with physical activity, self-reported health, and depressive symptoms.  Implications: This population-based study offers the first epidemiological evidence for a significant positive relationship between environmental volunteering and health and well-being outcomes. Further research, including intervention studies, is needed to confirm and shed additional light on these initial findings. PMID:20172902

  3. Cumulative risk, cumulative outcome: a 20-year longitudinal study.

    Directory of Open Access Journals (Sweden)

    Leslie Atkinson

    Full Text Available Cumulative risk (CR models provide some of the most robust findings in the developmental literature, predicting numerous and varied outcomes. Typically, however, these outcomes are predicted one at a time, across different samples, using concurrent designs, longitudinal designs of short duration, or retrospective designs. We predicted that a single CR index, applied within a single sample, would prospectively predict diverse outcomes, i.e., depression, intelligence, school dropout, arrest, smoking, and physical disease from childhood to adulthood. Further, we predicted that number of risk factors would predict number of adverse outcomes (cumulative outcome; CO. We also predicted that early CR (assessed at age 5/6 explains variance in CO above and beyond that explained by subsequent risk (assessed at ages 12/13 and 19/20. The sample consisted of 284 individuals, 48% of whom were diagnosed with a speech/language disorder. Cumulative risk, assessed at 5/6-, 12/13-, and 19/20-years-old, predicted aforementioned outcomes at age 25/26 in every instance. Furthermore, number of risk factors was positively associated with number of negative outcomes. Finally, early risk accounted for variance beyond that explained by later risk in the prediction of CO. We discuss these findings in terms of five criteria posed by these data, positing a "mediated net of adversity" model, suggesting that CR may increase some central integrative factor, simultaneously augmenting risk across cognitive, quality of life, psychiatric and physical health outcomes.

  4. Mortality in acromegaly: a 20-year follow-up study.

    Science.gov (United States)

    Ritvonen, Elina; Löyttyniemi, Eliisa; Jaatinen, Pia; Ebeling, Tapani; Moilanen, Leena; Nuutila, Pirjo; Kauppinen-Mäkelin, Ritva; Schalin-Jäntti, Camilla

    2016-06-01

    It is unclear whether mortality still is increased in acromegaly and whether there are gender-related differences. We dynamically assessed outcome during long-term follow-up in our nationwide cohort. We studied standardized mortality ratios (SMRs) relative to the general population and causes of death in acromegaly (n=333) compared with age- and gender-matched controls (n=4995). During 20 (0-33) years follow-up, 113 (34%) patients (n=333, 52% women) and 1334 (27%) controls (n=4995) died (P=0.004). SMR (1.9, 95% CI: 1.53-2.34, Pacromegaly. Overall distribution of causes of death (Pacromegaly, but not in controls, causes of deaths shifted from 44% cardiovascular and 28% cancer deaths during the first decade, to 23% cardiovascular and 35% cancer deaths during the next two decades. In acromegaly, cancer deaths were mostly attributed to pancreatic adenocarcinoma (n=5), breast (n=4), lung (n=3) and colon (n=3) carcinoma. In acromegaly, men were younger than women at diagnosis (median 44.5 vs 50 years, Pacromegaly, men are younger at diagnosis and death than women. Compared with controls, mortality is increased during 20 years of follow-up, especially in women. Causes of deaths shift from predominantly cardiovascular to cancer deaths. © 2016 Society for Endocrinology.

  5. 20 year old lady with a paraspinal mass.

    LENUS (Irish Health Repository)

    O'Toole, Orna

    2010-05-01

    A 20 year old female presented with a 4 month history of right upper limb pain and paraesthesias. She had no systemic symptoms and no prior medical or family history of note. MRI revealed a right-sided intradural extramedullary mass extending from C7-T1 and displacing the spinal cord. While awaiting surgery her symptoms progressed to involve the right lower limb. She was re-imaged and the lesion now extended from C5 to T3 with spinal cord compression at C7-T1. The radiological features and recent rapid growth were felt to be in keeping with a large plexiform neurofibroma. The patient underwent emergency resection of the lesion and pathology revealed Hodgkin\\'s Lymphoma (HL)-mixed cellularity type. A mediastinal mass was identified on further imaging and biopsy confirmed the diagnosis of HL-stage IV. The patient is currently undergoing treatment with ABVD chemotherapy. CNS-HL is extremely rare and may occur de novo or in association with systemic disease. Lesions may be parenchymal or dural based and are usually intracranial with an increased risk of CNS involvement in HL-mixed-cellularity type as in our patient. This is the first report in the literature of CNS-HL radiologically mimicking a paraspinal plexiform neurofibroma.

  6. The Latest from LHCf

    CERN Multimedia

    2009-01-01

    At the end of September, the LHCf collaboration installed RadMon dosimeters inside the TAN absorbers containing the detectors. Being located on the same level as the LHCf detectors, the dosimeters will provide precise information on the particle dose received. These data will be visible online as they are acquired. Hitherto, the only dosimeters of this type were located underneath the TAN absorbers, which did not provide precise information on the particle dose received by the detectors. The LHCf experiment has been ready for a year and the LHCf the collaboration is eagerly awaiting circulation of the first particle beams in the LHC at the end of the autumn. LHCf Collaboration

  7. Older adults' alcohol consumption and late-life drinking problems: a 20-year perspective.

    Science.gov (United States)

    Moos, Rudolf H; Schutte, Kathleen K; Brennan, Penny L; Moos, Bernice S

    2009-08-01

    The aim of this study was to identify changes in patterns of alcohol consumption over a 20-year interval among older women and men, and to examine the associations between guideline-defined excessive drinking and late-life drinking problems. DESIGN, PARTICIPANTS AND MEASURES: A community sample of 719 adults between 55 and 65 years of age who consumed alcohol at or prior to baseline participated in a survey of alcohol consumption and drinking problems and was followed 10 years and 20 years later. The likelihood of excessive drinking declined over the 20-year interval as adults matured into their 70s and 80s. However, at ages 75-85, 27.1% of women and 48.6% of men consumed more than two drinks per day or seven drinks per week. At comparable guideline levels of alcohol consumption, older men were more likely to have drinking problems than were older women. Consumption of more than two drinks per day or seven drinks per week was identified as a potential conservative guideline for identifying excessive drinking associated with an elevated likelihood of drinking problems. A substantial percentage of older adults who consume alcohol engage in guideline-defined excessive drinking and incur drinking problems. The finding that older men may be more likely than older women to experience problems when they drink beyond guideline levels suggests that alcohol guidelines for men should not be set higher than those for women.

  8. Older Adults’ Alcohol Consumption and Late-Life Drinking Problems: A 20-Year Perspective

    Science.gov (United States)

    Moos, Rudolf H.; Schutte, Kathleen K.; Brennan, Penny L.; Moos, Bernice S.

    2009-01-01

    Aims The aim was to identify changes in patterns of alcohol consumption over a 20-year interval among older women and men, and to examine the associations between guideline-defined excessive drinking and late-life drinking problems. Design, Participants, and Measures A community sample of 719 adults between 55 and 65 years of age who consumed alcohol at or prior to baseline participated in a survey of alcohol consumption and drinking problems and was followed 10 years and 20 years later. Findings The likelihood of excessive drinking declined over the 20-year interval as adults matured into their 70s and 80s. However, at ages 75–85, 27% of women and 49% of men consumed more than 2 drinks per day or 7 drinks per week. At comparable guideline levels of alcohol consumption, older men were more likely to have drinking problems than were older women. Consumption of more than 2 drinks per day or 7 drinks per week was identified as a potential conservative guideline for identifying excessive drinking associated with an elevated likelihood of drinking problems. Conclusions A substantial percentage of older adults who consume alcohol engage in guideline-defined excessive drinking and incur drinking problems. The finding that older men may be more likely than older women to experience problems when they drink beyond guideline levels suggests that alcohol guidelines for men should not be set higher than those for women. PMID:19438836

  9. Latest results from ALICE

    CERN Document Server

    Scapparone, Eugenio

    2011-01-01

    In this paper selected results obtained by the ALICE experiment at the LHC will be presented. Data collected during the pp runs taken at sqrt(s)=0.9, 2.76 and 7 TeV and Pb-Pb runs at sqrt(s_NN)=2.76 TeV allowed interesting studies on the properties of the hadronic and nuclear matter: proton runs gave us the possibility to explore the ordinary matter at very high energy and up to very low pt, while Pb-Pb runs provided spectacular events where several thousands of particles produced in the interaction revealed how a very dense medium behaves, providing a deeper picture on the quark gluon plasma(QGP) chemical composition and dynamics.

  10. The Latest from LHCb

    CERN Multimedia

    2009-01-01

    This month the LHCb Collaboration has observed the first Cherenkov rings from the RICH1 detector. These rings were emitted by cosmic particles passing through the detector. Cherenkov radiation occurs when a charged particle passes through a medium faster than the speed of light. As it travels, the particle emits photons along a cone. This cone is measured and, along with a measurement of momentum, is used to identify the particle. There are two types of radiators in RICH1, the first gaseous and the other made from aerogel. Both rings seen on the picture are from the same particle passing through the two different radiators. This is the fist time that the RICH detector has seen a particle as it will see them when the LHC re-starts. It has also been a time for the experiment to begin commissioning. After network upgrades, LHCb held a commissioning week, an opportunity for physicists working on all the different detectors within LHCb...

  11. The Latest from CMS

    CERN Multimedia

    2009-01-01

    CMS is on track to be ready for physics one month in advance of the LHC restart. The final installations are being completed and tests are being run to ensure that the experiment is as well prepared as possible to exploit sustained LHC operation throughout 2010. Physics week in Bologna, Italy, was a valuable time for CMS collaborators to discuss preparations for numerous physics analyses, as well as the performance of the detector during the recent data-taking period with cosmics (CRAFT 09). During this five-week exercise, more than 300 million cosmic events were recorded with the magnetic field on. This large data-set is being used to further improve the sub-detector alignment, calibration and performance whilst awaiting p-p collisions. Meanwhile, in the experimental cavern, Wolfram Zeuner, Deputy Technical Coordinator of CMS, reports "We are now very nearly closed up again. We are just doing the final clean-up work and are ready t...

  12. Evolution of US DOE Performance Assessments Over 20 Years - 13597

    Energy Technology Data Exchange (ETDEWEB)

    Suttora, Linda C. [U.S. Department of Energy, Office of Site Restoration, 19901 Germantown Rd, Germantown, MD 20874-1290 (United States); Seitz, Roger R. [Savannah River National Laboratory, Savannah River Site, Bldg 773-43A, Aiken, SC 29808 (United States)

    2013-07-01

    Performance assessments (PAs) have been used for many years for the analysis of post-closure hazards associated with a radioactive waste disposal facility and to provide a reasonable expectation of the ability of the site and facility design to meet objectives for the protection of members of the public and the environment. The use of PA to support decision-making for LLW disposal facilities has been mandated in United States Department of Energy (US DOE) directives governing radioactive waste management since 1988 (currently DOE Order 435.1, Radioactive Waste Management). Prior to that time, PAs were also used in a less formal role. Over the past 20+ years, the US DOE approach to conduct, review and apply PAs has evolved into an efficient, rigorous and mature process that includes specific requirements for continuous improvement and independent reviews. The PA process has evolved through refinement of a graded and iterative approach designed to help focus efforts on those aspects of the problem expected to have the greatest influence on the decision being made. Many of the evolutionary changes to the PA process are linked to the refinement of the PA maintenance concept that has proven to be an important element of US DOE PA requirements in the context of supporting decision-making for safe disposal of LLW. The PA maintenance concept is central to the evolution of the graded and iterative philosophy and has helped to drive the evolution of PAs from a deterministic compliance calculation into a systematic approach that helps to focus on critical aspects of the disposal system in a manner designed to provide a more informed basis for decision-making throughout the life of a disposal facility (e.g., monitoring, research and testing, waste acceptance criteria, design improvements, data collection, model refinements). A significant evolution in PA modeling has been associated with improved use of uncertainty and sensitivity analysis techniques to support efficient

  13. Evolution Of USDOE Performance Assessments Over 20 Years

    Energy Technology Data Exchange (ETDEWEB)

    Seitz, Roger R. [Savannah River Site (SRS), Aiken, SC (United States); Suttora, Linda C. [U.S. Department of Energy, Office of Site Restoration, Germantown, MD (United States)

    2013-02-26

    Performance assessments (PAs) have been used for many years for the analysis of post-closure hazards associated with a radioactive waste disposal facility and to provide a reasonable expectation of the ability of the site and facility design to meet objectives for the protection of members of the public and the environment. The use of PA to support decision-making for LLW disposal facilities has been mandated in United States Department of Energy (USDOE) directives governing radioactive waste management since 1988 (currently DOE Order 435.1, Radioactive Waste Management). Prior to that time, PAs were also used in a less formal role. Over the past 20+ years, the USDOE approach to conduct, review and apply PAs has evolved into an efficient, rigorous and mature process that includes specific requirements for continuous improvement and independent reviews. The PA process has evolved through refinement of a graded and iterative approach designed to help focus efforts on those aspects of the problem expected to have the greatest influence on the decision being made. Many of the evolutionary changes to the PA process are linked to the refinement of the PA maintenance concept that has proven to be an important element of USDOE PA requirements in the context of supporting decision-making for safe disposal of LLW. The PA maintenance concept represents the evolution of the graded and iterative philosophy and has helped to drive the evolution of PAs from a deterministic compliance calculation into a systematic approach that helps to focus on critical aspects of the disposal system in a manner designed to provide a more informed basis for decision-making throughout the life of a disposal facility (e.g., monitoring, research and testing, waste acceptance criteria, design improvements, data collection, model refinements). A significant evolution in PA modeling has been associated with improved use of uncertainty and sensitivity analysis techniques to support efficient

  14. Evolution Of USDOE Performance Assessments Over 20 Years

    International Nuclear Information System (INIS)

    Seitz, Roger R.; Suttora, Linda C.

    2013-01-01

    Performance assessments (PAs) have been used for many years for the analysis of post-closure hazards associated with a radioactive waste disposal facility and to provide a reasonable expectation of the ability of the site and facility design to meet objectives for the protection of members of the public and the environment. The use of PA to support decision-making for LLW disposal facilities has been mandated in United States Department of Energy (USDOE) directives governing radioactive waste management since 1988 (currently DOE Order 435.1, Radioactive Waste Management). Prior to that time, PAs were also used in a less formal role. Over the past 20+ years, the USDOE approach to conduct, review and apply PAs has evolved into an efficient, rigorous and mature process that includes specific requirements for continuous improvement and independent reviews. The PA process has evolved through refinement of a graded and iterative approach designed to help focus efforts on those aspects of the problem expected to have the greatest influence on the decision being made. Many of the evolutionary changes to the PA process are linked to the refinement of the PA maintenance concept that has proven to be an important element of USDOE PA requirements in the context of supporting decision-making for safe disposal of LLW. The PA maintenance concept represents the evolution of the graded and iterative philosophy and has helped to drive the evolution of PAs from a deterministic compliance calculation into a systematic approach that helps to focus on critical aspects of the disposal system in a manner designed to provide a more informed basis for decision-making throughout the life of a disposal facility (e.g., monitoring, research and testing, waste acceptance criteria, design improvements, data collection, model refinements). A significant evolution in PA modeling has been associated with improved use of uncertainty and sensitivity analysis techniques to support efficient

  15. Evolution of US DOE Performance Assessments Over 20 Years - 13597

    International Nuclear Information System (INIS)

    Suttora, Linda C.; Seitz, Roger R.

    2013-01-01

    Performance assessments (PAs) have been used for many years for the analysis of post-closure hazards associated with a radioactive waste disposal facility and to provide a reasonable expectation of the ability of the site and facility design to meet objectives for the protection of members of the public and the environment. The use of PA to support decision-making for LLW disposal facilities has been mandated in United States Department of Energy (US DOE) directives governing radioactive waste management since 1988 (currently DOE Order 435.1, Radioactive Waste Management). Prior to that time, PAs were also used in a less formal role. Over the past 20+ years, the US DOE approach to conduct, review and apply PAs has evolved into an efficient, rigorous and mature process that includes specific requirements for continuous improvement and independent reviews. The PA process has evolved through refinement of a graded and iterative approach designed to help focus efforts on those aspects of the problem expected to have the greatest influence on the decision being made. Many of the evolutionary changes to the PA process are linked to the refinement of the PA maintenance concept that has proven to be an important element of US DOE PA requirements in the context of supporting decision-making for safe disposal of LLW. The PA maintenance concept is central to the evolution of the graded and iterative philosophy and has helped to drive the evolution of PAs from a deterministic compliance calculation into a systematic approach that helps to focus on critical aspects of the disposal system in a manner designed to provide a more informed basis for decision-making throughout the life of a disposal facility (e.g., monitoring, research and testing, waste acceptance criteria, design improvements, data collection, model refinements). A significant evolution in PA modeling has been associated with improved use of uncertainty and sensitivity analysis techniques to support efficient

  16. DGMK technical meeting: SCC - latest developments and experiences in practice. Papers; DGMK-Fachtagung: SCC - Neueste Entwicklungen und Erfahrungen aus der Praxis. Vortraege

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-07-01

    Occupational safety and health management systems were the topic of the DGMK meeting. Certification of industrial plants by Safety Certificat Contractors (SSC) becomes a competitive property in mineral oil industry. Experiences, training of employees, accident statistics and health improvement of various enterprises are reported. (uke)

  17. Results from the latest SN-4 multi-parametric benthic observatory experiment (MARsite EU project) in the Gulf of Izmit, Turkey: oceanographic, chemical and seismic monitoring

    Science.gov (United States)

    Embriaco, Davide; Marinaro, Giuditta; Frugoni, Francesco; Giovanetti, Gabriele; Monna, Stephen; Etiope, Giuseppe; Gasperini, Luca; Çağatay, Namık; Favali, Paolo

    2015-04-01

    An autonomous and long-term multiparametric benthic observatory (SN-4) was designed to study gas seepage and seismic energy release along the submerged segment of the North Anatolian Fault (NAF). Episodic gas seepage occurs at the seafloor in the Gulf of Izmit (Sea of Marmara, NW Turkey) along this submerged segment of the NAF, which ruptured during the 1999 Mw7.4 Izmit earthquake. The SN-4 observatory already operated in the Gulf of Izmit at the western end of the 1999 Izmit earthquake rupture for about one-year at 166 m water depth during the 2009-2010 experiment (EGU2014-13412-1, EGU General Assembly 2014). SN-4 was re-deployed in the same site for a new long term mission (September 2013 - April 2014) in the framework of MARsite (New Directions in Seismic Hazard assessment through Focused Earth Observation in the Marmara Supersite, http://marsite.eu/ ) EC project, which aims at evaluating seismic risk and managing of long-term monitoring activities in the Marmara Sea. A main scientific objective of the SN-4 experiment is to investigate the possible correlations between seafloor methane seepage and release of seismic energy. We used the same site of the 2009-2010 campaign to verify both the occurrence of previously observed phenomena and the reliability of results obtained in the previous experiment (Embriaco et al., 2014, doi:10.1093/gji/ggt436). In particular, we are interested in the detection of gas release at the seafloor, in the role played by oceanographic phenomena in this detection, and in the association of gas and seismic energy release. The scientific payload included, among other instruments, a three-component broad-band seismometer, and gas and oceanographic sensors. We present a technical description of the observatory, including the data acquisition and control system, results from the preliminary analysis of this new multidisciplinary data set, and a comparison with the previous experiment.

  18. Europe Unveils 20-Year Plan for Brilliant Future in Astronomy

    Science.gov (United States)

    2008-11-01

    Astronomy is enjoying a golden age of fundamental, exciting discoveries. Europe is at the forefront, thanks to 50 years of progress in cooperation. To remain ahead over the next two to three decades, Europe must prioritise and coordinate the investment of its financial and human resources even more closely. The ASTRONET network, backed by the entire European scientific community, supported by the European Commission, and coordinated by the CNRS, today presents its Roadmap for a brilliant future for European astronomy. ESO's European Extremely Large Telescope is ranked as one of two top-priority large ground-based projects. Astronet and the E-ELT ESO PR Photo 43a/08 The E-ELT Europe is a leader in astronomy today, with the world's most successful optical observatory, ESO's Very Large Telescope, and cutting-edge facilities in radio astronomy and in space. In an unprecedented effort demonstrating the potential of European scientific cooperation, all of European astronomy is now joining forces to define the scientific challenges for the future and construct a common plan to address them in a cost-effective manner. In 2007, a top-level Science Vision was prepared to assess the most burning scientific questions over the next quarter century, ranging from dark energy to life on other planets. European astronomy now presents its Infrastructure Roadmap, a comprehensive 20-year plan to coordinate national and community investments to meet these challenges in a cost-effective manner. The Roadmap not only prioritises the necessary new frontline research facilities from radio telescopes to planetary probes, in space and on the ground, but also considers such key issues as existing facilities, human resources, ICT infrastructure, education and outreach, and cost -- of operations as well as construction. This bold new initiative -- ASTRONET -- was created by the major European funding agencies with support from the European Commission and is coordinated by the National Institute

  19. 20 years of cleft lip and palate missions.

    Science.gov (United States)

    Lambrecht, J Thomas; Kreusch, Thomas; Marsh, Jeff L; Schopper, Christian

    2014-01-01

    Volunteer missions for cleft lip and palate (CLP) care in Indonesia (1991-1992), India (1994-2003), Bhutan (2005-2010), and Kenya (2011), took place always at the same Hospital in each country. Altogether over a thousand patients were operated using a conservative protocol: Safety first - no experiments. Five months and 5 kg were the basic rules. For the native doctors, training help for self-help was priority. In the announcements, patients with CLP were primarily addressed. Burns, contractions, tumors, and trauma-cases were the second priority. Fresh trauma was done in night shifts with the local surgeons in order not to interfere. Besides facial esthetics speech was the number one issue, following priorities fell into place. Cultural aspects played a certain role in the different countries and continents.

  20. 20 years of cleft lip and palate missions

    Science.gov (United States)

    Lambrecht, J. Thomas; Kreusch, Thomas; Marsh, Jeff L.; Schopper, Christian

    2014-01-01

    Volunteer missions for cleft lip and palate (CLP) care in Indonesia (1991-1992), India (1994-2003), Bhutan (2005-2010), and Kenya (2011), took place always at the same Hospital in each country. Altogether over a thousand patients were operated using a conservative protocol: Safety first - no experiments. Five months and 5 kg were the basic rules. For the native doctors, training help for self-help was priority. In the announcements, patients with CLP were primarily addressed. Burns, contractions, tumors, and trauma-cases were the second priority. Fresh trauma was done in night shifts with the local surgeons in order not to interfere. Besides facial esthetics speech was the number one issue, following priorities fell into place. Cultural aspects played a certain role in the different countries and continents. PMID:25593861

  1. Adolescents and Pornography: A Review of 20 Years of Research.

    Science.gov (United States)

    Peter, Jochen; Valkenburg, Patti M

    2016-01-01

    The goal of this review was to systematize empirical research that was published in peer-reviewed English-language journals between 1995 and 2015 on the prevalence, predictors, and implications of adolescents' use of pornography. This research showed that adolescents use pornography, but prevalence rates varied greatly. Adolescents who used pornography more frequently were male, at a more advanced pubertal stage, sensation seekers, and had weak or troubled family relations. Pornography use was associated with more permissive sexual attitudes and tended to be linked with stronger gender-stereotypical sexual beliefs. It also seemed to be related to the occurrence of sexual intercourse, greater experience with casual sex behavior, and more sexual aggression, both in terms of perpetration and victimization. The findings of this review need to be seen against the background of various methodological and theoretical shortcomings, as well as several biases in the literature, which currently precludes internally valid causal conclusions about effects of pornography on adolescents.

  2. Celebrating 20 years of the discovery of the top quark

    CERN Document Server

    Azzi, P

    2015-01-01

    An historical recount of the events leading to the discovery of the top quark in 1995 by the CDF and DO experiments at the Tevatron. 1 Introduction This presentation brings us back to the early nineties. It is interesting to picture ourselves without iphone and laptops, working on DEC VAX and having to stay in the office to work because there was no internet at home. The programming language was Fortran and plots were made with PAW. Detectors were becoming bigger and more complex, but no Silicon detector had been tried in a hadron collider yet. To put things in perspective for the LHC physicist of today: the MonteCarlo programs of the time did not differentiate between heavy and light quarks (VECBOS), there were no b-tagging algorithms, it was not clear that a Silicon detector could survive the radiation environement of an hadron collider such as the Tevatron and collecting data took a long time (one year for 20 pb-1). Nonetheless, working at the most powerful accelerator of the time was as exciting as it tod...

  3. Superior Canal Dehiscence Syndrome: Lessons from the First 20 Years

    Directory of Open Access Journals (Sweden)

    Bryan K. Ward

    2017-04-01

    Full Text Available Superior semicircular canal dehiscence syndrome was first reported by Lloyd Minor and colleagues in 1998. Patients with a dehiscence in the bone overlying the superior semicircular canal experience symptoms of pressure or sound-induced vertigo, bone conduction hyperacusis, and pulsatile tinnitus. The initial series of patients were diagnosed based on common symptoms, a physical examination finding of eye movements in the plane of the superior semicircular canal when ear canal pressure or loud tones were applied to the ear, and high-resolution computed tomography imaging demonstrating a dehiscence in the bone over the superior semicircular canal. Research productivity directed at understanding better methods for diagnosing and treating this condition has substantially increased over the last two decades. We now have a sound understanding of the pathophysiology of third mobile window syndromes, higher resolution imaging protocols, and several sensitive and specific diagnostic tests. Furthermore, we have a treatment (surgical occlusion of the superior semicircular canal that has demonstrated efficacy. This review will highlight some of the fundamental insights gained in SCDS, propose diagnostic criteria, and discuss future research directions.

  4. Overview of the latest HT-7 experiments

    International Nuclear Information System (INIS)

    Wan Baonian; Luo Jiarong; Li Jiangang

    2005-01-01

    An overview of the HT-7 experimental progress during 2003-2004 is presented. The operational scenarios of H-mode, negative reversed shear (RS) and high l i were investigated for quasi-steady-state high performance plasma discharges. Stationary internal transport barriers (ITBs) with normalized performance β N *H 89 > 1-3 have been obtained with combined injection of lower hybrid (LH) and ion Bernstein (IB) waves for a duration of several hundred energy confinement times in weak negative reversed shear. The maximum fraction of non-inductive current was >90% I p . The increase of the total injected power up to 1 MW did not degrade the plasma confinement significantly in the RS operational scenario. Plasma performance and duration were mainly limited by two kinds of MHD instabilities and recycling. The high l i plasma was created by fast plasma current ramp-down and sustained by central LHCD and IBW heating for a duration of >1 s with a strongly peaked electron temperature profile. The highest central electron temperature obtained was as much as 4.5 keV. Stationary improved confinement has been observed in the high l i plasma. The longest plasma discharge, with a duration of 240 s, T e (0) ∼ 1 keV and a central electron density of >0.8 x 10 19 m -3 , was achieved in 2004. A fully LHW current driven plasma without using ohmic current in the central solenoid coils was sustained for 80 s. The main limitation for the pulse length was due to the recycling, which caused an uncontrollable rise in the electron density. The poloidal large-scale ExB time-varying flows, electrostatic and magnetic Reynolds stress were directly measured in the boundary plasma of the HT-7 tokamak. (author)

  5. 20 years of RERTR. Where we are and where to go?

    International Nuclear Information System (INIS)

    Krull, W.; Jager, W.

    1997-01-01

    This review will not survey the 20 years with all the efforts made in different countries to develop higher density fuel, to perform test irradiations and typical prototype fuel irradiation experiments, post irradiation examinations and actual core conversions. The emphasis is directed to the situation a few years ago when efforts have been rapidly slowing down, and the situation today after having had an international wake up call and comparing these efforts with the primary demand to reduce the proliferation risk worldwide and to have this as an indispensable goal of the international politics. The RERTR program is being back on the stony way. There are some (many?) hopes but many doubts to have the RERTR program a real success. Such a success needs the strong continue support and activities of many governments and especially of the IAEA for years. (author)

  6. The latest electrical installation (I)

    International Nuclear Information System (INIS)

    Won, Jong Su

    1976-04-01

    This book deals with the latest electrical installation. The contents of this book are construction electrical installation, regulations related electrical installation, foundation and principle of wiring, main line feeder, lighting installation, power of wiring, main line feeder, lighting installation, power installation, method to read structure drawing for electrical construct drawing electric lamp wiring diagram, working drawing, material and tools and method of construction of electrical installation on types of wiring construction, metallic conduit, rigid poly-vinyl conduit wiring, bus duct work, cable work and insulation out of metal lathed.

  7. A History of the Environmental Management Advisory Board: 20 Years of Service and Partnership - 13219

    International Nuclear Information System (INIS)

    Ellis, Kristen; Schmitt, Elizabeth

    2013-01-01

    The Environmental Management Advisory Board (EMAB or Board) was chartered under the Federal Advisory Committee Act (FACA) in 1992 to provide the Assistant Secretary for Environmental Management (EM) with independent and external advice, information, and recommendations on corporate issues relating to accelerated site clean-up and risk reduction throughout the EM complex. Over the course of the past 20 years, the composition and focus of the Board have varied widely to address the changing needs of the program. EMAB began as the Environmental Restoration and Waste Management Advisory Committee, formed to provide advice on an EM Programmatic Environmental Impact Statement. In 1994, the Board was restructured to function more as an executive-level, limited member advisory board whose membership provides insight of leading industry experts and the viewpoints of representatives from critical stakeholder constituencies. Throughout the 20 years of its existence, EMAB has covered a wide variety of topics and produced nearly 200 recommendations. These recommendations have resulted in several policy changes and improvements within EM. Most recently, EMAB has been credited for its contribution to the EM Energy Park Initiative, forerunner of the DOE Asset Revitalization Initiative; creation of the EM Offices of Communications and External Affairs; improvement of acquisition and project management strategies and culture; and several recommendations related to the Waste Treatment Plant and the tank waste programs at Hanford and the Savannah River Site. The wealth of experience and knowledge the Assistant Secretary can leverage through utilization of the Board continues to support fulfillment of EM's mission. In commemoration of EMAB's 20. anniversary, this paper will provide further context for the evolution of the Board, the role FACA plays in its administration, and a look at the members' current objectives and EM's expectations for the future. (authors)

  8. A History of the Environmental Management Advisory Board: 20 Years of Service and Partnership - 13219

    Energy Technology Data Exchange (ETDEWEB)

    Ellis, Kristen; Schmitt, Elizabeth [Environmental Management Advisory Board, US DoE (United States)

    2013-07-01

    The Environmental Management Advisory Board (EMAB or Board) was chartered under the Federal Advisory Committee Act (FACA) in 1992 to provide the Assistant Secretary for Environmental Management (EM) with independent and external advice, information, and recommendations on corporate issues relating to accelerated site clean-up and risk reduction throughout the EM complex. Over the course of the past 20 years, the composition and focus of the Board have varied widely to address the changing needs of the program. EMAB began as the Environmental Restoration and Waste Management Advisory Committee, formed to provide advice on an EM Programmatic Environmental Impact Statement. In 1994, the Board was restructured to function more as an executive-level, limited member advisory board whose membership provides insight of leading industry experts and the viewpoints of representatives from critical stakeholder constituencies. Throughout the 20 years of its existence, EMAB has covered a wide variety of topics and produced nearly 200 recommendations. These recommendations have resulted in several policy changes and improvements within EM. Most recently, EMAB has been credited for its contribution to the EM Energy Park Initiative, forerunner of the DOE Asset Revitalization Initiative; creation of the EM Offices of Communications and External Affairs; improvement of acquisition and project management strategies and culture; and several recommendations related to the Waste Treatment Plant and the tank waste programs at Hanford and the Savannah River Site. The wealth of experience and knowledge the Assistant Secretary can leverage through utilization of the Board continues to support fulfillment of EM's mission. In commemoration of EMAB's 20. anniversary, this paper will provide further context for the evolution of the Board, the role FACA plays in its administration, and a look at the members' current objectives and EM's expectations for the future. (authors)

  9. Social class and gender patterning of insomnia symptoms and psychiatric distress: a 20-year prospective cohort study.

    Science.gov (United States)

    Green, Michael J; Espie, Colin A; Benzeval, Michael

    2014-05-25

    Psychiatric distress and insomnia symptoms exhibit similar patterning by gender and socioeconomic position. Prospective evidence indicates a bi-directional relationship between psychiatric distress and insomnia symptoms so similarities in social patterning may not be coincidental. Treatment for insomnia can also improve distress outcomes. We investigate the extent to which the prospective patterning of distress over 20 years is associated with insomnia symptoms over that period. 999 respondents to the Twenty-07 Study had been followed for 20 years from approximately ages 36-57 (73.2% of the living baseline sample). Psychiatric distress was measured using the GHQ-12 at baseline and at 20-year follow-up. Gender and social class were ascertained at baseline. Insomnia symptoms were self-reported approximately every five years. Latent class analysis was used to classify patterns of insomnia symptoms over the 20 years. Structural Equation Models were used to assess how much of the social patterning of distress was associated with insomnia symptoms. Missing data was addressed with a combination of multiple-imputation and weighting. Patterns of insomnia symptoms over 20 years were classified as either healthy, episodic, developing or chronic. Respondents from a manual social class were more likely to experience episodic, developing or chronic patterns than those from non-manual occupations but this was mostly explained by baseline psychiatric distress. People in manual occupations experiencing psychiatric distress however were particularly likely to experience chronic patterns of insomnia symptoms. Women were more likely to experience a developing pattern than men, independent of baseline distress. Psychiatric distress was more persistent over the 20 years for those in manual social classes and this effect disappeared when adjusting for insomnia symptoms. Irrespective of baseline symptoms, women, and especially those in a manual social class, were more likely than men to

  10. PREVAIL: latest electron optics results

    Science.gov (United States)

    Pfeiffer, Hans C.; Golladay, Steven D.; Gordon, Michael S.; Kendall, Rodney A.; Lieberman, Jon E.; Rockrohr, James D.; Stickel, Werner; Yamaguchi, Takeshi; Okamoto, Kazuya; Umemoto, Takaaki; Shimizu, Hiroyasu; Kojima, Shinichi; Hamashima, Muneki

    2002-07-01

    The PREVAIL electron optics subsystem developed by IBM has been installed at Nikon's facility in Kumagaya, Japan, for integration into the Nikon commercial EPL stepper. The cornerstone of the electron optics design is the Curvilinear Variable Axis Lens (CVAL) technique originally demonstrated with a proof of concept system. This paper presents the latest experimental results obtained with the electron optical subsystem at Nikon's facility. The results include micrographs illustrating proper CVAL operation through the spatial resolution achieved over the entire optical field of view. They also include data on the most critical issue of the EPL exposure approach: subfield stitching. The methodology of distortion correction will be described and both micrographs and metrology data of stitched subfields will be presented. This paper represents a progress report of the IBM/Nikon alliance activity on EPL.

  11. Artificial sensory organs: latest progress.

    Science.gov (United States)

    Nakamura, Tatsuo; Inada, Yuji; Shigeno, Keiji

    2018-03-01

    This study introduces the latest progress on the study of artificial sensory organs, with a special emphasis on the clinical results of artificial nerves and the concept of in situ tissue engineering. Peripheral nerves have a strong potential for regeneration. An artificial nerve uses this potential to recover a damaged peripheral nerve. The polyglycolic acid collagen tube (PGA-C tube) is a bio-absorbable tube stuffed with collagen of multi-chamber structure that consists of thin collagen films. The clinical application of the PGA-C tube began in 2002 in Japan. The number of PGA-C tubes used is now beyond 300, and satisfactory results have been reported on peripheral nerve repairs. This PGA-C tube is also effective for patients suffering from neuropathic pain.

  12. Latest ATLAS results on $\\phi_s$

    CERN Document Server

    AUTHOR|(INSPIRE)INSPIRE-00222462; The ATLAS collaboration

    2017-01-01

    New Physics effects beyond the predictions of the Standard Model may manifest in the $CP$-violation of $b$-hadron decays. This paper presents the latest analysis of $B^0_s \\to J/\\psi\\phi$ decay at the ATLAS experiment, measuring the $CP$-violating phase $\\phi_s$, the decay width $\\Gamma_s$ and the difference of widths between the mass eigenstates $\\Delta\\Gamma_s$. The latest results are using integrated luminosity of 14.3 fb$^{-1}$ collected by the ATLAS detector from $\\sqrt{s}$ = 8 TeV $pp$ collisions at the Large Hadron Collider, and are statistically combined with the results from 4.9 fb$^{-1}$ of $\\sqrt{s}$ = 7 TeV data, leading to: \\begin{eqnarray*} \\phi_s & = & -0.090 \\pm 0.078 \\;\\mathrm{(stat.)} \\pm 0.041 \\;\\mathrm{(syst.)~rad} ,\\;\\;\\\\ \\Delta\\Gamma_s & = & 0.085 \\pm 0.011 \\;\\mathrm{(stat.)} \\pm 0.007 \\;\\mathrm{(syst.)~ps}^{-1} ,\\;\\;\\\\ \\Gamma_s & = & 0.675 \\pm 0.003 \\;\\mathrm{(stat.)} \\pm 0.003 \\;\\mathrm{(syst.)~ps}^{-1}. \\end{eqnarray*} The results are also presented in the form...

  13. The latest figures on uranium

    International Nuclear Information System (INIS)

    Vance, R.

    2010-01-01

    According to the latest figures on uranium, soon to be published by the NEA, uranium resources, production and demand are all on the rise. Exploration efforts have increased recently in line with the expected expansion of nuclear energy in the coming years. Total identified resources have grown and are now sufficient to cover 100 years of supply at 2008 rates of consumption. Costs of production have, however, also increased. This article is based on the latest edition of the 'Red Book', Uranium 2009: Resources, Production and Demand, which presents the results of the most recent biennial review of world uranium market fundamentals and a statistical profile of the world uranium industry as of 1 January 2009. It contains official data provided by OECD Nuclear Energy Agency (NEA) and International Atomic Energy Agency (IAEA) member countries on uranium exploration, resources, production and reactor-related requirements. Projections of nuclear generating capacity and reactor-related uranium requirements through 2035 are also provided as well as a discussion of long-term uranium supply and demand issues. Despite recent declines stemming from the global financial crisis, world demand for electricity is expected to continue to grow significantly over the next several decades to meet the needs of an increasing population and economic growth. The recognition by an increasing number of governments that nuclear power can produce competitively priced, base-load electricity that is essentially free of greenhouse gas emissions, coupled with the role that nuclear can play in enhancing security of energy supply, increases the prospects for growth in nuclear generating capacity, although the magnitude of that growth remains to be determined. Regardless of the role that nuclear energy ultimately plays in meeting rising electricity demand, the uranium resource base is more than adequate to meet projected requirements. Meeting even high-case requirements to 2035 would consume less

  14. Zika virus: the latest newcomer

    Directory of Open Access Journals (Sweden)

    Juan-Carlos eSaiz

    2016-04-01

    Full Text Available Since the beginning of this century, humanity has been facing a new emerging, or re-emerging, virus threat almost every year: West Nile, Influenza A, avian flu, dengue, Chikungunya, SARS, MERS, Ebola, and now Zika, the latest newcomer. Zika virus (ZIKV, a flavivirus transmitted by Aedes mosquitoes, was identified in 1947 in a sentinel monkey in Uganda, and later on in humans in Nigeria. The virus was mainly confined to the African continent until it was detected in south-east Asia the 1980´s, then in the Micronesia in 2007 and, more recently in the Americas in 2014, where it has displayed an explosive spread, as advised by the World Health Organization (WHO, which resulted in the infection of hundreds of thousands of people. ZIKV infection was characterized by causing a mild disease presented with fever, headache, rash, arthralgia, and conjunctivitis, with exceptional reports of an association with Guillain-Barre syndrome (GBS and microcephaly. However, since the end of 2015, an increase in the number of GBS associated cases and an astonishing number of microcephaly in foetus and new-borns in Brazil have been related to ZIKV infection, raising serious worldwide public health concerns. Clarifying such worrisome relationships is, thus, a current unavoidable goal. Here, we extensively review what is currently known about ZIKV, from molecular biology, transmission routes, ecology and epidemiology, to clinical manifestations, pathogenesis, diagnosis, prophylaxis and public health.

  15. Latest design of gate valves

    Energy Technology Data Exchange (ETDEWEB)

    Kurzhofer, U.; Stolte, J.; Weyand, M.

    1996-12-01

    Babcock Sempell, one of the most important valve manufacturers in Europe, has delivered valves for the nuclear power industry since the beginning of the peaceful application of nuclear power in the 1960s. The latest innovation by Babcock Sempell is a gate valve that meets all recent technical requirements of the nuclear power technology. At the moment in the United States, Germany, Sweden, and many other countries, motor-operated gate and globe valves are judged very critically. Besides the absolute control of the so-called {open_quotes}trip failure,{close_quotes} the integrity of all valve parts submitted to operational forces must be maintained. In case of failure of the limit and torque switches, all valve designs have been tested with respect to the quality of guidance of the gate. The guidances (i.e., guides) shall avoid a tilting of the gate during the closing procedure. The gate valve newly designed by Babcock Sempell fulfills all these characteristic criteria. In addition, the valve has cobalt-free seat hardfacing, the suitability of which has been proven by friction tests as well as full-scale blowdown tests at the GAP of Siemens in Karlstein, West Germany. Babcock Sempell was to deliver more than 30 gate valves of this type for 5 Swedish nuclear power stations by autumn 1995. In the presentation, the author will report on the testing performed, qualifications, and sizing criteria which led to the new technical design.

  16. The Latest Books on Globalization

    Directory of Open Access Journals (Sweden)

    Elia Zaru

    2016-12-01

    Full Text Available The latest books published on globalization raise interesting issues which reflect upon the very complexity of the process we are facing. In The Great Convergence: Information Technology and the New Globalization Richard Baldwin proposes a history of globalization divided into two stages. As Baldwin argues, the process of globalization has to be divided into “old” and “new” age. The “old” globalization took place between 1820 and 1990. It was characterized by the “great divergence”, that is by the centralization of world income in today’s wealthy nations. However, since 1990 the sharing of world income has plummeted to where it was in 1900. According to Baldwin, this reversal of fortune is a symptom of a shift in the globalization process. The “new” globalization, driven by information technology, has combined high tech with low wages, and lead simultaneously to the industrialization of developing nations and deindustrialization of developed ones. This is the “great convergence”: in the “new” globalization rich and developing nations are alike and they face equal global challenges.

  17. Surgical removal of intra-abdominal intrauterine devices at one center in a 20-year period.

    Science.gov (United States)

    Ertopcu, Kenan; Nayki, Cenk; Ulug, Pasa; Nayki, Umit; Gultekin, Emre; Donmez, Aysegul; Yildirim, Yusuf

    2015-01-01

    To review 20 years of experience of the removal of intra-abdominal intrauterine devices (IUDs) and to compare the surgical methods used. In a retrospective study, charts dating from between September 1, 1992, and August 31, 2012, were reviewed. Patients were eligible for inclusion when they had an IUD surgically removed by minilaparotomy or laparoscopy at a tertiary referral center in Izmir, Turkey. Among the 36 eligible women, 18 (50%) had undergone laparoscopy and 18 (50%) had undergone minilaparotomy. Mean operation length was 55.3±6.3 minutes in the laparoscopy group and 29.1±4.2 minutes in the minilaparotomy group (P=0.008). Conversion to full laparotomy was necessary in 4 (22%) women in the laparoscopy group and 1 (6%) in the minilaparotomy group (P=0.02). Perioperative complications were observed in 5 (14%) women, with no difference in frequency between groups (P=0.09). Total cost of medical/surgical procedures was US$436.4±35.4 for the laparoscopy group and $323.4±21.3 for the minilaparotomy group (P=0.04). Minilaparotomy seems to be an important alternative to laparoscopy for the removal of intra-abdominal IUDs. This procedure should be an integral part of gynecologic surgical training. Copyright © 2014 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.

  18. “The cut has a female face”: 20 years after Beijing platform, inequalities are deepening

    Directory of Open Access Journals (Sweden)

    Gabriela Bard Wigdor

    2017-01-01

    Full Text Available Argentina is experiencing a political and economic transition that in a few months show social impact of extreme worry. In clear contradiction with the commitments assumed by our country in the Beijing conference (1995, and after 20 years of its celebration, Argentine’s women as European’s, appear to face new setbacks in the conquered social rights and little prospect to make progress on outstanding debts of Democracy. Workers fired massively from state areas, closures of programs "Assistance to Victims of Domestic Violence", resource restrictions for sexual and reproductive health policies; and many social implications due to the economic policies  that capitalism implements in its neoliberal version, exacerbating the subordinate status of women because of their gender, class and geographical measures. As it is shown in Argentinian history and current European experience, especially in the popular sectors, on the economic crisis, women constitute the reserve army of labor that becomes available and flexible. Indeed, when the state ceases to assume functions related to its role as rights guarantor and social policies maker, women replace it and assume more responsibilities than usual, almost always related to health, nutrition and care, affecting their access and practice of their own human rights.

  19. Foreign Bodies in the Female Urinary Bladder: 20-Year Experience in Ramathibodi Hospital

    Directory of Open Access Journals (Sweden)

    Wachira Kochakarn

    2008-07-01

    Conclusion: Foreign bodies in the urinary bladder represent a urological challenge that requires prompt management. The suspected history and presenting symptoms are crucial and lead to fur-ther investigations. Gentle endoscopic management is the main treatment with a high success rate.

  20. The scientific challenges of NEPA: Future directions based on 20 years of experience

    International Nuclear Information System (INIS)

    Hildebrand, S.G.; Cannon, J.B.

    1989-01-01

    January 1, 1990, marked the 20th anniversary of the signing of the National Environmental Policy Act (NEPA). Since this law was enacted, numerous institutions have assisted federal agencies in the implementation of NEPA, including the preparation of environmental impact statements and environmental assessments. The Ninth Oak Ridge National Laboratory Life Sciences Symposium was dedicated to the celebration of this anniversary. The symposium was held October 24--27, 1989, in Knoxville, Tennessee. The intent of the symposium was (1) to review what has been learned while performing NEPA assessments, (2) to summarize the state-of-the-art in methods and approaches, and (3) to define future opportunities and new approaches required to link high quality science to the decision-making process

  1. Efficacy of external fractionated radiation therapy in the treatment of meningiomas: a 20-year experience

    International Nuclear Information System (INIS)

    Pourel, Nicolas; Auque, Jean; Bracard, Serge; Hoffstetter, Sylvette; Luporsi, Elisabeth; Vignaud, Jean-Michek; Bey, Pierre

    2001-01-01

    Background: This is a retrospective analysis of a series of meningiomas treated by radiotherapy. Materials and methods: From 1978 to 1997, 45 patients with intracranial meningiomas were referred for external fractionated radiotherapy at Centre Alexis Vautrin. All patients were given 50-70 Gy to the tumor bed (median: 56 Gy), 1.8-2 Gy per fraction. Results: Evaluation was performed in June 1999 using the Kaplan-Meyer actuarial method with a median follow-up of 30 months (range: 1-166), relapse-free survivals (RFSs) were 75% at 5 years and 67% at 8 years; overall survival (OS) was 74% at 5 and 8 years. For the 26 benign histologically documented lesions, RFSs were 95% at 5 years and 81% at 8 years; OS was 85% at 5 and 8 years. One major radiation-induced complication occurred in this series (decline of cognitive function). According to the indication of radiotherapy, we divided the series into four groups: postoperative irradiation after a first subtotal resection (11 patients), 5-year RFS was 90%; after first recurrence (±salvage surgery, 14 patients), 73%; after further recurrence (±salvage surgery, 11 patients), 67%; as exclusive treatment (nine patients), 80%. Atypical and malignant lesions (n=7) all relapsed before 24 months of follow-up, all patients but one died before 42 months. Age at the time of irradiation (≥60 vs. <60 years) and radiotherapy dose (≥60 vs. <60 Gy) did not influence local control or OS. Atypical and malignant lesions (WHO grades II and III) meningiomas had a worse outcome than benign lesions (WHO grade I, P<0.01). Conclusions: These results compare favorably with previously published data. External fractionated radiotherapy is well tolerated and effective. There is still a debate about the place of radiotherapy in the treatment of meningiomas: after subtotal resection, should radiotherapy be given postoperatively or at the time of progression? Should radiotherapy replace surgery when the risk of postoperative sequellae is high? Prospective randomized trials would be required to address these issues

  2. A 20-Year Educational Experiment: The Diaspora of Adolescence. The Iconoclast.

    Science.gov (United States)

    McMurtry, John

    1994-01-01

    Describes adolescent development in a family where children were treated as equal partners in decision making and behavior. Maintains that adolescents will grow from the relationship of shared power and responsibility. Discusses issues such as sexuality, television viewing, and athletics. (CFR)

  3. Ethnic-based federalism and ethnicity in Ethiopia : reassessing the experiment after 20 years

    NARCIS (Netherlands)

    Abbink, G.J.

    2011-01-01

    One of the core principles instituted by the post-1991 government in Ethiopia that took power after a successful armed struggle was ethnic-based federalism, informed by a neo-Leninist political model called revolutionary democracy. In this model, devised by the reigning Tigray People's Liberation

  4. Ethnic-based federalism and ethnicity in Ethiopia: reassessing the experiment after 20 years

    NARCIS (Netherlands)

    Abbink, G.J.

    2012-01-01

    One of the core principles instituted by the post-1991 government in Ethiopia that took power after a successful armed struggle was ethnic-based federalism, informed by a neo-Leninist political model called revolutionary democracy. In this model, devised by the reigning Tigray People's Liberation

  5. Retrospective Evaluation of Children with Congenital Pulmonary Airway Malformation: A Single Center Experience of 20 Years.

    Science.gov (United States)

    Ortac, Ragip; Diniz, Gulden; Yildirim, Hulya Tosun; Aktas, Safiye; Karaca, Irfan

    2016-01-01

    Congenital pulmonary airway malformation (CPAM) is an uncommon congenital abnormality of the lungs that generally presents during prenatal period or early childhood. In this study, we aimed to evaluate clinical and pathologic findings of the children with CPAMs who were referred to our center between 1992 and 2011. We reviewed 19 children with CPAM, who were diagnosed and treated at the Izmir Dr. Behçet Uz Children's Hospital between 1992 and 2011. All of them are alive and have been still followed up by our center. The study population consisted of 9 boys (47.4%) and 10 girls (52.6%) with a mean age of 3.26 (1 month - 13 years). Most newborns had respiratory distress, while recurrent pulmonary infections were detected in older children. Surgical treatment was performed on patients with subtypes I (n = 4; 21.1%), II (n = 8; 42.1%), III (n = 5; 26.3%), and IV (n = 2; 10.5%). In 13 cases (63.4%), lesions were located in the right lung and in almost all cases lesions were confined to one lobe. A one-month- old child with type I CPAM had multiple lesions involving two lobes and in only a newborn with type II CPAM, lesions were located bilaterally. There was no type 0 cases in this series. All cases were treated with lobectomy without any complication. In the present study, a realistic comprehensive picture of CPAM in a central children's hospital has been provided. In addition, we want to emphasize that complications and unnecessary medical treatment could be reduced with early surgery.

  6. Managing high risk glaucoma with the Ahmed valve implant: 20 years of experience.

    Science.gov (United States)

    Rotsos, Tryfon; Tsioga, Anastasia; Andreanos, Konstantinos; Diagourtas, Andreas; Petrou, Petros; Georgalas, Ilias; Papaconstantinou, Dimitrios

    2018-01-01

    To estimate the efficacy and safety of the Ahmed implant in patients with high risk for failure after glaucoma surgery. In 342 eyes of 342 patients with refractory glaucoma, even with application of medical treatment, the Ahmed valve was introduced for intraocular pressure (IOP) control, in the period of the last 20y. The nature of glaucoma was neovascular in 162 eyes, pseudophakic or aphakic in 49 eyes, inflammatory in 29 eyes and non working previous antiglaucomatic surgical interventions in 102 eyes. Follow-up ranged from 18 to 120mo with a mean follow-up of 63.2mo. IOP before the operation decreased from 31.6±10.4 mm Hg to 18.3±5.4 mm Hg (no systemic treatment) at the end of follow up period. When we compared the IOP values before the operation using ANOVA showed statistically significant difference ( P glaucoma, 63.2% in aphakic glaucoma and 73.8% in non working previous antiglaucomatic surgical interventions. Complications due to the implant were: serous choroidal detachment in 14.8%, blockage of the tube in 2.8%, malposition of the tube in 4.9%, suprachoroidal hemorrhage in 2.1%, cataract progression in 39.6% (phakic eyes), shallow anterior chamber in 9.2%, hyphaema in 28.9%, exposure of valve in 2.6%, exposure of tube in 9.3%, hypotony in 4.9% and conjunctival fibrosis in 41.5%. Despite the fact that Ahmed valve implant had suchlike results as other implants concerning the IOP control, complications rate due to hypotony or over filtration in the first days after the intervention are not that frequent as with other valve implants.

  7. Managing high risk glaucoma with the Ahmed valve implant: 20 years of experience

    Directory of Open Access Journals (Sweden)

    Tryfon Rotsos

    2018-02-01

    Full Text Available AIM: To estimate the efficacy and safety of the Ahmed implant in patients with high risk for failure after glaucoma surgery. METHODS: In 342 eyes of 342 patients with refractory glaucoma, even with application of medical treatment, the Ahmed valve was introduced for intraocular pressure (IOP control, in the period of the last 20y. The nature of glaucoma was neovascular in 162 eyes, pseudophakic or aphakic in 49 eyes, inflammatory in 29 eyes and non working previous antiglaucomatic surgical interventions in 102 eyes. RESULTS: Follow-up ranged from 18 to 120mo with a mean follow-up of 63.2mo. IOP before the operation decreased from 31.6±10.4 mm Hg to 18.3±5.4 mm Hg (no systemic treatment at the end of follow up period. When we compared the IOP values before the operation using ANOVA showed statistically significant difference (P<0.001. The success rate was 85.2% during the first semester, 76.8% at 12mo and 50.3% at the end of follow up period (18 to 120mo after implantation. Success rate was 25.7% in neovascular glaucoma, 63.2% in aphakic glaucoma and 73.8% in non working previous antiglaucomatic surgical interventions. Complications due to the implant were: serous choroidal detachment in 14.8%, blockage of the tube in 2.8%, malposition of the tube in 4.9%, suprachoroidal hemorrhage in 2.1%, cataract progression in 39.6% (phakic eyes, shallow anterior chamber in 9.2%, hyphaema in 28.9%, exposure of valve in 2.6%, exposure of tube in 9.3%, hypotony in 4.9% and conjunctival fibrosis in 41.5%. CONCLUSION: Despite the fact that Ahmed valve implant had suchlike results as other implants concerning the IOP control, complications rate due to hypotony or over filtration in the first days after the intervention are not that frequent as with other valve implants.

  8. Extramammary Paget’s Disease: 20 Years of Experience in Chinese Population

    Directory of Open Access Journals (Sweden)

    Jimmy Yu Wai Chan

    2012-01-01

    Full Text Available Background. To examine the results of treatment of Extramammary Paget’s disease (EMPD in ethnic Chinese. Method. Between 1990 and 2010, patients treated for EMPD were reviewed. Data were analyzed retrospectively. Results. Forty-eight patients were treated by surgical resection. Local recurrence rate was 14.6%. The postresection defects were repaired by primary closure (8.3%, partial thickness skin graft (72.9%, or local/regional flaps (18.8%. Dermal invasion was found in 9 patients (18.8%. Seven patients (14.6% developed regional lymph node metastasis (concurrent with surgery, =1; subsequent to surgery, =6, and 3 patients (6.3% had systemic metastasis after surgery. The presence of dermal invasion was associated with significantly higher incidence of regional lymph nodes and systemic metastasis. The incidence of associated internal malignancy was 8.3%. Conclusion. The mainstay of treatment for EMPD is surgery. Pathological dermal invasion increases the chance of regional lymph node as well as systemic metastasis. The association with internal malignancy warrants preoperative endoscopic examination in all patients.

  9. Over 20 years experience with aortic homograft in aortic valve replacement during acute infective endocarditis.

    Science.gov (United States)

    Solari, Silvia; Mastrobuoni, Stefano; De Kerchove, Laurent; Navarra, Emiliano; Astarci, Parla; Noirhomme, Philippe; Poncelet, Alain; Jashari, Ramadan; Rubay, Jean; El Khoury, Gebrine

    2016-12-01

    Despite the controversy, the aortic homograft is supposedly the best option in acute infective endocarditis (AIE), due to its resistance to reinfection. However, the technical complexity and the risk of structural deterioration over time have limited its utilization. The aim of this study was to evaluate the long-term results of aortic homograft for the treatment of infective endocarditis in our institution with particular attention to predictors of survival and homograft reoperation. The cohort includes 112 patients who underwent aortic valve replacement with an aortic homograft for AIE between January 1990 and December 2014. Fifteen patients (13.4%) died during the first 30 days after the operation. Two patients were lost to follow-up after discharge from the hospital; therefore, 95 patients were available for long-term analysis. The median duration of follow-up was 7.8 years (IQR 4.7-17.6). Five patients (5.3%) suffered a recurrence of infective endocarditis (1 relapse and 4 new episodes). Sixteen patients (16.8%) were reoperated for structural valve degeneration (SVD; n = 14, 87.5%) or for infection recurrence (n = 2, 12.5%). Freedom from homograft reoperation for infective endocarditis or structural homograft degeneration at 10 and 15 years postoperatively was 86.3 ± 5.5 and 47.3 ± 11.0%, respectively. For patients requiring homograft reoperation, the median interval to reintervention was 11.6 years (IQR 8.3-14.5). Long-term survival was 63.6% (95% CI 52.4-72.8%) and 53.8% (95% CI 40.6-65.3%) at 10 and 15 years, respectively. The use of aortic homograft in acute aortic valve endocarditis is associated with a remarkably low risk of relapsing infection and very acceptable long-term survival. The risk of reoperation due to SVD is significant after one decade especially in young patients. The aortic homograft seems to be ideally suited for reconstruction of the aortic valve and cardiac structures damaged by the infective process especially in early surgery. © The Author 2016. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.

  10. Experience with Periodic Safety Review (PSR) at Kozloduy NPP after 20 years of operation

    International Nuclear Information System (INIS)

    Popov, V.

    2011-01-01

    Conclusion: Measures in the long-term Programs for improving safety and radiation protection of unit 5&6, based on PSR outcome and addressed on the units’ operation licence renewal are under way. • NPP Kozloduy intends to fulfils requirements on modern nuclear power plants which occasionally exceeds limits of the effective national nuclear legislation

  11. Experience in cochlear reimplantation. Descriptive study of a 20-year period.

    Science.gov (United States)

    Gutiérrez-Salazar, Andrés; Cop, Constanze; Osorio-Acosta, Ángel; Borkoski-Barreiro, Silvia; Falcón-González, Juan C; Ramos-Macías, Ángel

    2015-01-01

    The cochlear implant is a surgical procedure that has increased substantially, because the paediatric population is diagnosed and implanted early and because there are increased potential indications. This device has the inherent risk of failure in performance, as dies any active medical device, which is the most common cause of implant removal. Our goal was to understand what the causes that produced removal in our series were, and confirm if these conformed to reality as reviewed in the literature. This was a retrospective, descriptive, observational study of 859 cochlear implant surgeries carried out between October 1991 and May 2011. The causes of implant removal were classified according to the European Consensus Statement on Cochlear Implant Failures and Explantations. The reimplantation rate was 6.16% (n=51). The most common reason for removal was technical device failure (45.5%), followed by infection/rejection (23.6%) and upgrade (12.7%). Less common causes: there were 3 cases (5.6%) of electrode misplacement, 2 cases (3.6%) of labyrinthine ossification, 2 (3.6%) as a result of head trauma, 2 (3.6%) from need for nuclear magnetic resonance imaging and 1 case (1.8%) from psychiatric illness. Cochlear reimplantation is a safe procedure, with a low complication rate. In our centre, it reaches an overall rate of 6.16%. Technical device failure remains the most common cause of this procedure, although there is a significant percentage of reimplantation for device update. Copyright © 2014 Elsevier España, S.L.U. and Sociedad Española de Otorrinolaringología y Patología Cérvico-Facial. All rights reserved.

  12. Radiotherapy for stage I Hodgkin's disease: 20 years experience at St Bartholomew's Hospital

    International Nuclear Information System (INIS)

    Ganesan, T.S.; Wrigley, P.F.M.; Murray, P.A.

    1990-01-01

    One hundred and one consecutive patients with newly diagnosed stage I Hodgkin's disease (HD) received treatment at St Bartholomew's Hospital, between 1968 and 1987, with a median follow-up of 12 years. Actuarial analysis predicts 78% to be alive and without relapse of Hodgkin's disease at 15 years. Ninety evaluable patients received either mantle or inverted 'Y' radiotherapy. Histology at presentation was nodular sclerosing (39), lymphocytic predominant (27) or mixed cellularity (24). The presenting site was neck (78), axilla (6) groin (4) and mediastinum (2). Complete remission was achieved in all evaluable patients, the actuarial proportion in remission being 75% at 15 years. Factors predictive of a prolonged remission were pathological staging versus clinical staging and lymph node size < 3 cm. Actuarial overall survival in these 90 patients was 75% at 15 years. Relapse of HD has occurred in 18 patients. Second remission was achieved in 15/18. The actuarial rate of second remission and survival was 40% at 10 years. Sixteen patients have died, 7 of Hodgkin's disease, 7 of unrelated causes and 2 of second malignancy. A further 3 patients who developed second malignancy are still alive. At 15 years the actuarial mortality related to HD was 12%. These results confirm the importance of long follow up to assess the efficacy of primary therapy. (author)

  13. Portal vein thrombosis in children and adolescents: 20 years experience of a pediatric hepatology reference center

    Directory of Open Access Journals (Sweden)

    Priscila Menezes Ferri

    2012-03-01

    Full Text Available CONTEXT: Portal vein thrombosis refers to a total or partial obstruction of the blood flow in this vein due to a thrombus formation. It is an important cause of portal hypertension in the pediatric age group with high morbidity rates due to its main complication - the upper gastrointestinal bleeding. OBJECTIVE: To describe a group of patients with portal vein thrombosis without associated hepatic disease of the Pediatric Hepatology Clinic of the Hospital das Clínicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil with emphasis on diagnosis, presentation form and clinical complications, and the treatment of portal hypertension. METHODS: This is a descriptive study of a series of children and adolescents cases assisted from January 1990 to December 2010. The portal vein thrombosis diagnosis was established by ultrasound. RESULTS: Of the 55 studied patients, 30 (54.5% were male. In 29 patients (52.7%, none of the risk factors for portal vein thrombosis was observed. The predominant form of presentation was the upper gastrointestinal bleeding (52.7%. In 20 patients (36.4%, the initial manifestation was splenomegaly. During the whole following period of the study, 39 patients (70.9% showed at least one episode of upper gastrointestinal bleeding. The mean age of patients in the first episode was 4.6 ± 3.4 years old. The endoscopic procedure carried out in the urgency or electively for search of esophageal varices showed its presence in 84.9% of the evaluated patients. The prophylactic endoscopic treatment was performed with endoscopic band ligation of varices in 31.3% of patients. Only one died due to refractory bleeding. CONCLUSIONS: The portal vein thrombosis is one of the most important causes of upper gastrointestinal bleeding in children. In all non febrile children with splenomegaly and/or hematemesis and without hepatomegaly and with normal hepatic function tests, it should be suspect of portal vein thrombosis. Thus, an appropriate diagnostic and treatment approach is desirable in an attempt to reduce morbidity and mortality.

  14. Implications of surgical intervention in the treatment of neuroblastomas. 20-year experience of a single institution

    International Nuclear Information System (INIS)

    Tajiri, Tatsuro; Souzaki, Ryota; Kinoshita, Yoshiaki; Koga, Yuhki; Suminoe, Aiko; Hara, Toshiro; Taguchi, Tomoaki

    2012-01-01

    The implications of surgical intervention for neuroblastomas were assessed in one institution. We analyzed the clinical characteristics and extension of resection in 123 pediatric patients with neuroblastoma diagnosed between 1985 and 2004. The 5-year survival rate of the 82 patients under 12 months of age, 59 of whom were treated with complete resection of the primary tumor, was 97%. The 5-year survival rate of the 41 patients over 12 months of age did not differ significantly according to whether complete (n=19) or incomplete resection (n=22) was performed (46 vs. 38%, respectively). No local recurrence was observed in ten patients over 12 months of age with stage 4 disease who underwent complete resection of the primary tumor; however, four of these ten patients died of metastatic recurrence. Considering that the majority of infantile neuroblastomas in this study had favorable biology, complete resection might be unnecessary for patients under 12 years of age. For advanced neuroblastomas in patients over 12 months of age, the main treatment for metastasis is systemic chemotherapy, although extirpation of the primary tumor without extensive surgery might prevent local recurrence when combined with radiation therapy. (author)

  15. Exploring diffusion and sorption processes at the Mont Terri rock laboratory (Switzerland): lessons learned from 20 years of field research

    Energy Technology Data Exchange (ETDEWEB)

    Leupin, O.X. [National Cooperative for the Disposal of Radioactive Waste (NAGRA), Wettingen (Switzerland); Van Loon, L.R. [Paul Scherrer Institute PSI, Villigen (Switzerland); Gimmi, T. [Institute of Geological Sciences, University of Berne, Berne (Switzerland); Gimmi, T. [Institute of Environmental Assessment and Water Research IDAEA-CSIC, Barcelona (Spain); and others

    2017-04-15

    Transport and retardation parameters of radionuclides, which are needed to perform a safety analysis for a deep geological repository for radioactive waste in a compacted claystone such as Opalinus Clay, must be based on a detailed understanding of the mobility of nuclides at different spatial scales (laboratory, field, geological unit). Thanks to steadily improving experimental designs, similar tracer compositions in different experiments and complementary small laboratory-scale diffusion tests, a unique and large database could be compiled. This paper presents the main findings of 20 years of diffusion and retention experiments at the Mont Terri rock laboratory and their impact on safety analysis. (authors)

  16. Survival and Competitiveness of Bradyrhizobium japonicum Strains 20 Years after Introduction into Field Locations in Poland.

    Science.gov (United States)

    Narożna, Dorota; Pudełko, Krzysztof; Króliczak, Joanna; Golińska, Barbara; Sugawara, Masayuki; Mądrzak, Cezary J; Sadowsky, Michael J

    2015-08-15

    It was previously demonstrated that there are no indigenous strains of Bradyrhizobium japonicum forming nitrogen-fixing root nodule symbioses with soybean plants in arable field soils in Poland. However, bacteria currently classified within this species are present (together with Bradyrhizobium canariense) as indigenous populations of strains specific for nodulation of legumes in the Genisteae tribe. These rhizobia, infecting legumes such as lupins, are well established in Polish soils. The studies described here were based on soybean nodulation field experiments, established at the Poznań University of Life Sciences Experiment Station in Gorzyń, Poland, and initiated in the spring of 1994. Long-term research was then conducted in order to study the relation between B. japonicum USDA 110 and USDA 123, introduced together into the same location, where no soybean rhizobia were earlier detected, and nodulation and competitive success were followed over time. Here we report the extra-long-term saprophytic survival of B. japonicum strains nodulating soybeans that were introduced as inoculants 20 years earlier and where soybeans were not grown for the next 17 years. The strains remained viable and symbiotically competent, and molecular and immunochemical methods showed that the strains were undistinguishable from the original inoculum strains USDA 110 and USDA 123. We also show that the strains had balanced numbers and their mobility in soil was low. To our knowledge, this is the first report showing the extra-long-term persistence of soybean-nodulating strains introduced into Polish soils and the first analyzing the long-term competitive relations of USDA 110 and USDA 123 after the two strains, neither of which was native, were introduced into the environment almost 2 decades ago. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

  17. The ICN Leadership For Change™ Programme – 20 years of growing influence

    Science.gov (United States)

    Ferguson, Stephanie L.; Rifai, Fatima Al; Maay'a, Maisa; Nguyen, Luu Bich; Qureshi, Kristine; Tse, Alice M.; Casken, John; Parsons, Teresa; Shannon, Maureen; Napa, Maria Diana; Samson-Langidrik, Malia; Jeadrik, Glorine

    2017-01-01

    Aim The aim of this article was to present experiences from the field in the context of the International Council of Nurses' Leadership for Change™ programme, which celebrates 20 years of excellence in 2016 for developing the leadership and management capacity of nurses worldwide. Background The programme was launched in 1996 in order to boost nurse participation in the healthcare policy-making process, globally, and to foster within the nursing profession the requisite skills for nurses to lobby for and assume a greater responsibility in the leadership and management of health care services. Introduction Over the course of two decades, the programme has been implemented in cooperation between ICN, national nurses associations, the World Health Organization, Ministries of Health and a variety of donor organizations such as the W.K. Kellogg Foundation and development agencies such as USAID and AUSAID. The programme has been implemented in more than 60 nations throughout Africa, Asia, Europe, the Middle East, Latin America and the Pacific Islands, to name a few regions. Methods This article offers an overview of the impact that certified ICN LFC nurse trainers and their colleagues have had in the United Arab Emirates, Vietnam and the United States of America and is affiliated islands and the North Pacific Islands. Results Twenty years of growth and empowerment are now the ongoing legacy of the ICN LFC Program, which has graduated and deployed nurse trainers around the world and achieved significant advances in the professional development of nurse leaders on an international scale. Implications for nursing and health policy Nurse leaders can improve the health and well-being of their nations in collaboration with consumers and other key stakeholders. Nurse leaders are critical in improving health systems, their work places and broader societal challenges through sound nursing practice, education, research and evidence-based health and social policy change. PMID

  18. 20 Years of persistent identifiers - Which systems are here to stay?

    Science.gov (United States)

    Klump, Jens; Huber, Robert; Lehnert, Kerstin

    2016-04-01

    Web-based persistent identifiers have been around for more than 20 years, a period long enough to start observing patterns of success and failure. Persistent identifiers were invented to address challenges arising from the distributed and disorganised nature of the internet, which not only allowed new technologies to emerge, it also made it difficult to maintain a persistent record of science. Persistent identifiers now allow unambiguous identification of resources on the net. The expectations were that persistent identifiers would lead to greater accessibility, transparency and reproducibility of research results. Over the past two decades a number of persistent identifier systems have been built, one of them being Digital Object Identifiers (DOI). While DOI were originally invented by the publishing industry, they quickly became an established way for the identification of research resources. At first, these resources referred to scholarly literature and related resources. Other identifier systems, some of them using DOI as an example, were developed as grass-roots efforts by the scientific community. The concept of using persistent identifiers has since been expanded to other, non-textual resources, like datasets (DOI, EPIC) and geological specimens (IGSN), and more recently to authors and contributors of scholarly works (ORCID), and to software and instruments. A common witticism states that "a great thing about standards is that there are so many to choose from." Setting up identifier systems is technically trivial. The real challenge lies in creating a governance system for the respective identifiers. Which systems will stand the test of time? Drawing on data from the Registry of Research Data Repositories (re3data.org) and our own experience in the field, this presentation looks at the history and adoption of existing identifier systems and how this gives us some indications towards factors influencing sustainability of these systems.

  19. Latest results from Daya Bay

    Science.gov (United States)

    Vorobel, Vit; Daya Bay Collaboration

    2017-07-01

    The Daya Bay Reactor Neutrino Experiment was designed to measure θ 13, the smallest mixing angle in the three-neutrino mixing framework, with unprecedented precision. The experiment consists of eight functionally identical detectors placed underground at different baselines from three pairs of nuclear reactors in South China. Since Dec. 2011, the experiment has been running stably for more than 4 years, and has collected the largest reactor anti-neutrino sample to date. Daya Bay is able to greatly improve the precision on θ 13 and to make an independent measurement of the effective mass splitting in the electron antineutrino disappearance channel. Daya Bay can also perform a number of other precise measurements, such as a high-statistics determination of the absolute reactor antineutrino flux and spectrum, as well as a search for sterile neutrino mixing, among others. The most recent results from Daya Bay are discussed in this paper, as well as the current status and future prospects of the experiment.

  20. Evaluation of results of more than 20 years treating hyperthyroidism by I-131

    International Nuclear Information System (INIS)

    Phan, S.A.; Mai, T.K.; Tran, D.H.

    2001-01-01

    The authors have summarized their works of more than 20 years using I-131 for treatment and close observation of 723 patients with hyperthyroidism in 1000 ones in the Nuclear Medicine Department, Bach Mai University Hospital in Hanoi to collect data and draw experience for the report. Patient selection for the treatment is based on clinical features and laboratory tests results by the Nuclear Medicine Department such as thyroid uptake, scintigraphy and RIA determinations of thyroid hormones. I-131 dose is determined in compliance with a prevailing formula. The average dose is 6.2 ± 1.1 mCi (that is 233.1 ± 40.7 MBq). The average number of times is 1.3 time for one patient. The results are as follows: Euthyroid status after 4- year following- up from date of I-131 dose administration: 72.3%; Persistent or recurrent hyperthyroidism: 20.0%; Hypothyroid complications: appear 4 to 12 months after date of I-131 administration: 3.0%; appear 4 years after date of I-131 administration: 7.7%; appear 6 years after date of I-131 administration. 14.0%; so the cumulative hypothyroid rate is 2.3% per year. No occurrence of other serious complications by all the observed patients. This is therefore a safe, efficient treatment method to be applied on a large scale including adolescents and children. However, much more study has still to be made on the dose due to high rate of recurrence of the therapeutic method although the hypothyroid complications cases are not serious. Hyperthyroidism is a common health problem in Viet Nam. Previously, only anti-thyroid drugs and surgery were used. Use of I-131 was firstly introduced to Viet Nam in the Nuclear Medicine Department in Bach Mai in 1974 and afterwards applied larger nationwide. Initial therapeutic results have been published in national medical magazines. This is a general study aiming at analyzing the way to carry out the work and get experience and recommendation from gained results for further work in the future. (author)

  1. Current knowledge from experimental works with radioprotective drugs from the viewpoint of latest scientific research; Aktualne poznatky z experiment8lnych prac s rastlinami s radioprotektivnym ucinkom vo svetle najnovsich vedeckych vyskumov

    Energy Technology Data Exchange (ETDEWEB)

    Skalka, J [Ustav vyzivy, dietetiky a krmovinarstva, Univerzita veterinarskeho lekarstva, 04181 Kosice (Slovakia)

    2008-06-15

    The protection of both human and animal population against a radiation impairment proves to be an impulse for continuous intensive searching for plants with radioprotective properties, identification of their radioprotective components and examination of their effects both in vivo an in vitro. I am presenting the results as well as knowledge of a latest scientific research in this field with testing the following plants: Vigna radiata, Mentha piperita, Citrus aurantium var. amara, Syzygium cumini, Tinospora cordifolia, Aegle marmelos, Phyllanthus amarus, Aloe vera, Angelica sinensis, Rosemarinus officinalis, Panax ginseng, Hippophae rhamnoides, Ocimum sanctum, Crataegus microphylla. (authors)

  2. 29 CFR 4219.14 - Amount of liability for 20-year-limitation amounts.

    Science.gov (United States)

    2010-07-01

    ... amount equal to the present value of all initial withdrawal liability payments for which the employer was not liable pursuant to section 4219(c)(1)(B) of ERISA. The present value of such payments shall be... 29 Labor 9 2010-07-01 2010-07-01 false Amount of liability for 20-year-limitation amounts. 4219.14...

  3. Characterizing Adult Sleep Behavior Over 20 Years-The Population-Based Doetinchem Cohort Study

    NARCIS (Netherlands)

    Zomers, Margot L; Hulsegge, Gerben; van Oostrom, Sandra H; Proper, Karin I.; Verschuren, W M Monique; Picavet, H. Susan J

    2017-01-01

    Study Objectives: To describe sleep duration patterns of adults over a 20-year period; to compare sociodemographic, lifestyle, and health characteristics across these patterns; and to relate the patterns to sleep quality. Methods: The study population consisted of 3695 adults aged 20 to 59 years at

  4. Reflecting on 20+ Years of “Executive Program in Defense Decision Making” Curriculum

    OpenAIRE

    2017-01-01

    CCMR News Article CCMR hosted a version of its biannual “Executive Program in Defense Decision Making” offering for 21 international military and civilian participants, from November 6-17, 2017. Often described as CCMR’s “flagship” course, this curriculum has been offered at the Naval Postgraduate School (NPS) in Monterey, California for over 20 years.

  5. 20 Years after "The Ontogeny of Human Memory: A Cognitive Neuroscience Perspective," Where Are We?

    Science.gov (United States)

    Jabès, Adeline; Nelson, Charles A.

    2015-01-01

    In 1995, Nelson published a paper describing a model of memory development during the first years of life. The current article seeks to provide an update on the original work published 20 years ago. Specifically, we review our current knowledge on the relation between the emergence of explicit memory functions throughout development and the…

  6. Looking Back and Ahead: 20 Years of Technologies for Language Learning

    Science.gov (United States)

    Godwin-Jones, Robert

    2016-01-01

    Over the last 20 years Robert Godwin-Jones has written 48 columns on "Emerging Technologies"; an additional six columns have been written by guest columnists. Several topics have been re-examined in regular intervals of approximately five years, namely digital literacy (Vol. 4, Num. 2; Vol. 10, Num. 2; Vol. 14, Num. 3; Vol. 19, Num. 3)…

  7. Aboveground biomass and nutrient accumulation 20 years after clear-cutting a southern Appalachian watershed

    Science.gov (United States)

    Katherine J. Elliott; Lindsay R. Boring; Wayne T. Swank

    2002-01-01

    In 1975, we initiated a long-term interdisciplinary study of forest watershed ecosystem response to clear- cutting and cable logging in watershed 7 at the Coweeta Hydrologic Laboratory in the southern Appalachian Mountains of North Carolina. This paper describes ~20 years of change in species composition, aboveground biomass, leaf area index (LAI),...

  8. Decreasing Sports Activity with Increasing Age? Findings from a 20-Year Longitudinal and Cohort Sequence Analysis

    Science.gov (United States)

    Breuer, Christoph; Wicker, Pamela

    2009-01-01

    According to cross-sectional studies in sport science literature, decreasing sports activity with increasing age is generally assumed. In this paper, the validity of this assumption is checked by applying more effective methods of analysis, such as longitudinal and cohort sequence analyses. With the help of 20 years' worth of data records from the…

  9. 20 Years of Autonomy and Technology: How Far Have We Come and Where to Next?

    Science.gov (United States)

    Reinders, Hayo; White, Cynthia

    2016-01-01

    Learner autonomy has become an assumed goal of language education in many parts of the world. In the 20 years since the launch of "Language Learning & Technology," the relationship among computer-assisted language learning research and practice and autonomy has become both more complex and more promising. This article traces how the…

  10. A ponderosa pine-lodgepole pine spacing study in central Oregon: results after 20 years.

    Science.gov (United States)

    K.W. Seidel

    1989-01-01

    The growth response after 20 years from an initial spacing study established in a ponderosa pine (Pinus ponderosa Dougl. ex Laws.) and lodgepole pine (Pinus contorta Dougl. ex Loud.) plantation was measured in central Oregon. The study was designed to compare the growth rates of pure ponderosa pine, pure lodgepole pine, and a...

  11. Low-cost regeneration techniques for mixed-species management – 20 years later

    Science.gov (United States)

    Thomas A. Waldrop; Helen H. Mohr

    2012-01-01

    Four variations of the fell-and-burn technique, a low-cost regeneration system developed for pine-hardwood mixtures in the Southern Appalachian Mountains, were tested in the Piedmont of South Carolina. All variations successfully improved the commercial value of low-quality hardwood stands by introducing a pine component. After 20 years, pines were almost as numerous...

  12. Self-Rated Activity Levels and Longevity: Evidence from a 20 Year Longitudinal Study

    Science.gov (United States)

    Mullee, Mark A.; Coleman, Peter G.; Briggs, Roger S. J.; Stevenson, James E.; Turnbull, Joanne C.

    2008-01-01

    The study reports on factors predicting the longevity of 328 people over the age of 65 drawn from an English city and followed over 20 years. Both the reported activities score and the individual's comparative evaluation of their own level of activity independently reduced the risk of death, even when health and cognitive status were taken into…

  13. The Deep Space Network: The challenges of the next 20 years - The 21st century

    Science.gov (United States)

    Dumas, L. N.; Edwards, C. D.; Hall, J. R.; Posner, E. C.

    1990-01-01

    The Deep Space Network (DSN) has been the radio navigation and communications link between NASA's lunar and deep space missions for 30 years. In this paper, new mission opportunities over the next 20 years are discussed. The system design drivers and the DSN architectural concepts for those challenges are briefly considered.

  14. Assessing Side Effects of Pharmacotherapy Treatment of Bipolar Disorder: A 20-Year Review of the Literature

    Science.gov (United States)

    Matson, Johnny L.; Gonzalez, Melissa L.; Smith, Kimberly R.; Terlonge, Cindy; Thorson, Ryan T.; Dixon, Dennis R.

    2006-01-01

    A substantial literature on the effective treatment of bipolar disorder has begun to appear, particularly in the last 20 years.The majority of treatments studied have employed medications, particularly mood stabilizers, a typical antipsychotics and antidepressants. Most treatments produce side effects and medications are no exception. A review of…

  15. Suicide risk in schizophrenia – a follow-up study after 20 years ...

    African Journals Online (AJOL)

    Objective. This study re-evaluated, after a period of 20 years, a cohort of patients with schizophrenia who had been considered to be at high risk for suicide. The outcome and social factors associated with their suicide risk were investigated over the two decades. Method. Subjects were contacted and interviewed face to face ...

  16. 20 years PSI accelerator. The speeches; 20 Jahre PSI-Beschleuniger. Die Festreden

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-12-31

    This publication contains the text of four papers presented at the occasion of the 20 year Symposium of the PSI accelerator. The papers dealt with the following topics: Scientific research and its dual interaction with industry and with the general public, the history of the PSI accelerator, {mu}-n-{gamma} investigations on high temperature superconductors, therapy with charged particles. figs., tabs., refs.

  17. The Parent-Child Home Program in Western Manitoba: A 20-Year Evaluation

    Science.gov (United States)

    Gfellner, Barbara M.; McLaren, Lorraine; Metcalfe, Arron

    2008-01-01

    This article is a 20-year evaluation of the Parent-Child Home Program (PCHP) of Child and Family Services in Western Manitoba. Following Levenstein's (1979, 1988) approach, home visitors model parent-child interchanges using books and toys to enhance children's cognitive development through appropriate parenting behaviors. The evaluation provides…

  18. 3D Heart Model and 4D Flow MRI 20 Years after Spiral Arterial Switch Operation.

    Science.gov (United States)

    Sievers, Hans-Hinrich; Kheradvar, Arash; Kramer, Hans-Heiner; Rickers, Carsten

    2016-12-01

    Case of a patient is presented here 20 years after spiral direct anastomosis of the great arteries in an arterial switch operation. Three-dimensional model of the heart combined with four-dimensional flow magnetic resonance imaging presents a novel comprehensive way to assess surgical results.

  19. Synergy and Diffusion with a Borax-Copper Hydroxide Groundline Preservative: 20 Year Update

    Science.gov (United States)

    Stan Lebow; Bessie Woodward; Bill Abbott; Mike West

    2014-01-01

    A groundline remedial treatment containing 3.1% copper hydroxide (2% elemental copper) and 40% sodium tetraborate decahydrate (borax) was applied to unseasoned pine posts prior to placement in a test site in southern Mississippi. The soundness of the posts was periodically evaluated using a push test. After 3.5, 6.5, 10, 15 and 20 years, sections were taken from two...

  20. Review of 20 years research in fatigue of high pressure loaded components

    Energy Technology Data Exchange (ETDEWEB)

    Thumser, Rayk [Bauhaus Univ. Weimar (Germany). Materialforschungs- und -pruefanstalt; Scheibe, Wolfgang

    2011-07-01

    This paper gives an overview of the research in fatigue of high pressure loaded components. In the last 20 years the main research was carried out in Germany. This research was mainly driven by the fatigue requirements for high pressure loaded Diesel engine injection parts as common rails, injectors and pipes. (orig.)

  1. In Patience and Hope: A 20-Year Narrative Study of a Family, School, and Community Partnership

    Science.gov (United States)

    Higgins, Ann; Deegan, James G.

    2009-01-01

    This case study describes a 20-year journey of educational transformation from 1985 to 2005 in a bellwether, or highly developed, instance of one school, family, and community partnership--the Kileely Community Project--situated in a large social housing project in Limerick City in the Midwestern region of the Republic of Ireland. The study is a…

  2. A case of lymphogranuloma venereum of 20 years' duration. Isolation of Chlamydia trachomatis from perianal lesions.

    Science.gov (United States)

    Dan, M; Rotmensch, H H; Eylan, E; Rubinstein, A; Ginsberg, R; Liron, M

    1980-01-01

    Chlamydia trachomatis was isolated from perianal lesions in a patient in whom lymphogranuloma venereum had been diagnosed 20 years previously. Treatment with tetracycline resulted in a pronounced improvement. Although C trachomatis is known to persist for a long time in the host, isolation of the micro-organism from infected tissues after such a prolonged period has not previously been reported. Images PMID:7427708

  3. Energy secretary Spencer Abraham announces department of energy 20-year science facility plan

    CERN Multimedia

    2003-01-01

    "In a speech at the National Press Club today, U.S. Energy Secretary Spencer Abraham outlined the Department of Energy's Office of Science 20-year science facility plan, a roadmap for future scientific facilities to support the department's basic science and research missions. The plan prioritizes new, major scientific facilities and upgrades to current facilities" (1 page).

  4. Spacing and shrub competition influence 20-year development of planted ponderosa pine

    Science.gov (United States)

    William W. Oliver

    1990-01-01

    Growth and stand development of ponderosa pine (Pinus ponderosa) were monitored for 20 years after planting at five different square spacings (6, 9, 12, 15, and 18 ft) in the presence or absence of competing shrubs on the westside Sierra Nevada. Mean tree size was positively correlated and stand values negatively correlated with spacing in the...

  5. Fasting proinsulin levels are significantly associated with 20 year cancer mortality rates. The Hoorn Study

    NARCIS (Netherlands)

    Walraven, I.; van 't Riet, E.; Stehouwer, C.D.A.; Polak, B.C.P.; Moll, A.C.; Dekker, J.M.; Nijpels, G.

    2013-01-01

    Aims/hypothesis: Proinsulin is possibly associated with cancer through activation of insulin receptor isoform A. We sought to investigate the associations between proinsulin and 20 year cancer mortality rates. Methods: The study was performed within the Hoorn Study, a population-based study of

  6. Satisfaction with dental care and life-course predictors: A 20-year prospective study of a Swedish 1942 birth cohort?

    Science.gov (United States)

    Ekbäck, Gunnar; Ordell, Sven; Ståhlnacke, Katri

    2016-01-01

    The aim was to assess the impact of care experience, health factors and socioeconomic factors on satisfaction with dental care across time and to assess the stability or change in levels of self-reported satisfaction with dental care in individuals as they progress from middle age to early old age. The present work is based on five separate data collections from a cohort study with 3585 individuals responding in all years of the survey. Data collection was conducted in 1992 when the subjects were 50 years of age and again 5, 10, 15 and 20 years later. Absolute stability in satisfaction with dental care was assessed by calculating the proportion of individuals who maintained their position in the same category from one survey period to another. Changes across time were tested using Cochran's Q test. Satisfaction with dental care across the 20-year survey period was modeled using the generalized estimating equation (GEE). The result showed that 85% of women and 83% of men remained satisfied with dental care. Binomial GEE revealed no statistical significant change in satisfaction with dental care between 1992-2012. In sum, this study has shown that this age group, born in 1942, was stably satisfied with dental care between age 50 and age 70, despite all changes during this time period. Females are more satisfied than men and the most important factors are the experience of attention during the last visit, satisfaction with dental appearance and good chewing capability.

  7. Latest results from KLOE-2

    Directory of Open Access Journals (Sweden)

    Bloise Caterina

    2014-01-01

    Full Text Available The KLOE experiment at the Frascati φ–factory recently obtained results on i CPT and Lorentz invariance tests from the study of quantum interference of the neutral kaon pairs; ii precision measurement of the branching fraction, BR(K+ → π+π−π+(γ = 0.05565 ± 0.00031stat ± 0.00025syst, and iii on dark photon searches with the analysis of the e+e− → µµγ final state. We have also studied the transition form factors of the φ meson to the pseudoscalars, π0 and η, that is presented in a separate contribution to this volume.

  8. Glaucoma: Symptoms, Diagnosis, Treatment and Latest Research

    Science.gov (United States)

    ... of this page please turn Javascript on. Feature: Glaucoma Glaucoma: Symptoms, Diagnosis, Treatment and Latest Research Past Issues / Fall 2009 Table of Contents Symptoms and Diagnosis Glaucoma can develop in one or both eyes. Often ...

  9. 20 years of ClO measurements in the Antarctic lower stratosphere

    Science.gov (United States)

    Nedoluha, Gerald E.; Connor, Brian J.; Mooney, Thomas; Barrett, James W.; Parrish, Alan; Gomez, R. Michael; Boyd, Ian; Allen, Douglas R.; Kotkamp, Michael; Kremser, Stefanie; Deshler, Terry; Newman, Paul; Santee, Michelle L.

    2016-08-01

    We present 20 years (1996-2015) of austral springtime measurements of chlorine monoxide (ClO) over Antarctica from the Chlorine Oxide Experiment (ChlOE1) ground-based millimeter wave spectrometer at Scott Base, Antarctica, as well 12 years (2004-2015) of ClO measurements from the Aura Microwave Limb Sounder (MLS). From August onwards we observe a strong increase in lower stratospheric ClO, with a peak column amount usually occurring in early September. From mid-September onwards we observe a strong decrease in ClO. In order to study interannual differences, we focus on a 3-week period from 28 August to 17 September for each year and compare the average column ClO anomalies. These column ClO anomalies are shown to be highly correlated with the average ozone mass deficit for September and October of each year. We also show that anomalies in column ClO are strongly anti-correlated with 30 hPa temperature anomalies, both on a daily and an interannual timescale. Making use of this anti-correlation we calculate the linear dependence of the interannual variations in column ClO on interannual variations in temperature. By making use of this relationship, we can better estimate the underlying trend in the total chlorine (Cly = HCl + ClONO2 + HOCl + 2 × Cl2 + 2 × Cl2O2 + ClO + Cl). The resultant trends in Cly, which determine the long-term trend in ClO, are estimated to be -0.5 ± 0.2, -1.4 ± 0.9, and -0.6 ± 0.4 % year-1, for zonal MLS, Scott Base MLS (both 2004-2015), and ChlOE (1996-2015) respectively. These trends are within 1σ of trends in stratospheric Cly previously found at other latitudes. The decrease in ClO is consistent with the trend expected from regulations enacted under the Montreal Protocol.

  10. 20 Years of ClO Measurements in the Antarctic Lower Stratosphere

    Science.gov (United States)

    Nedoluha, Gerald E.; Connor, Brian J.; Mooney, Thomas; Barrett, James W.; Parrish, Alan; Gomez, R. Michael; Boyd, Ian; Allen, Douglas R.; Kotkamp, Michael; Kremser, Stefanie; hide

    2016-01-01

    We present 20 years (1996-2015) of austral springtime measurements of chlorine monoxide (ClO) over Antarctica from the Chlorine Oxide Experiment (ChlOEl) ground-based millimeter wave spectrometer at Scott Base, Antarctica, as well 12 years (2004-2015) of ClO measurements from the Aura Microwave Limb Sounder (MLS). From August onwards we observe a strong increase in lower stratospheric ClO, with a peak column amount usually occurring in early September. From mid-September onwards we observe a strong decrease in ClO. In order to study interannual differences, we focus on a 3-week period from 28 August to 17 September for each year and compare the average column ClO anomalies. These column ClO anomalies are shown to be highly correlated with the average ozone mass deficit for September and October of each year. We also show that anomalies in column ClO are strongly anti-correlated with 30 hPa temperature anomalies, both on a daily and an interannual timescale. Making use of this anti-correlation we calculate the linear dependence of the interannual variations in column C1O on interannual variations in temperature. By making use of this relationship, we can better estimate the underlying trend in the total chlorine (Cl(sub y) = HCl + ClONO2 + HOCl + 2 x Cl2 + 2 x Cl2+ ClO + Cl). The resultant trends in Cl(sub y), which determine the long-term trend in ClO, are estimated to be -0.5 +/-0.2, -1.40.9, and -0.60.4% per year, for zonal MLS, Scott Base MLS (both 2004-2015), and ChlOE (1996-2015) respectively. These trends are within 1sigma of trends in stratospheric Cl(sub y) previously found at other latitudes. The decrease in ClO is consistent with the trend expected from regulations enacted under the Montreal Protocol.

  11. Editorial: Latest methods and advances in biotechnology.

    Science.gov (United States)

    Lee, Sang Yup; Jungbauer, Alois

    2014-01-01

    The latest "Biotech Methods and Advances" special issue of Biotechnology Journal continues the BTJ tradition of featuring the latest breakthroughs in biotechnology. The special issue is edited by our Editors-in-Chief, Prof. Sang Yup Lee and Prof. Alois Jungbauer and covers a wide array of topics in biotechnology, including the perennial favorite workhorses of the biotech industry, Chinese hamster ovary (CHO) cell and Escherichia coli. Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  12. The Latest from the LHC

    CERN Multimedia

    In SM18 six magnets have been cold tested with good results. It has also been a good week for cyostating with five more magnets completed. In sector 3-4 interconnection work and welding has started in the area damaged on 19 September last year. Interconnection work is also ongoing on the replacement magnet for the faulty dipole removed from sector 1-2. Three separate teams are now working in the three sectors to install the new DN200 pressure release nozzles. In total 27 magnets have been completed so far, with 34 nozzles welded. A new study is also underway to include a similar pressure release system for both the stand-alone magnets (SAMs) and the triplet magnets. All about Chamonix At the public session of the LHCC (the LHC experiments committee) held Wednesday, 18 February Steve Myers, Director for Accelerators and Technology, reviewed the discussions on the LHC at the Chamonix workshop. He explained the scenarios being studied to implement the machine consolidation measures and resume operation. The ...

  13. Latest news from the LHC

    CERN Document Server

    CERN Bulletin

    2010-01-01

    Last week the LHC passed the threshold of 3 pb-1 total integrated luminosity delivered to the experiments, of which about half was delivered in just one week. These excellent results were achieved by operating the machine with up to 50 nominal bunches per beam.   After a very successful week that saw intense beams circulating for long periods (a total of 76.5 hours of stable beams, corresponding to about 40% of the time), there has been a technical stop this week. Over the coming days, experts will work on bunch trains with 150 ns spacing between bunches (the current minimum spacing is 1000 ns). This will involve making the necessary changes throughout the injector chain, as well as in the LHC itself. In the LHC, bunch trains imply working with a crossing angle throughout the machine cycle, in order to avoid unwanted parasitic collisions, which means that the whole process of injection, ramp and squeeze will have to be re-commissioned. The task also includes re-commissioning all the protection syste...

  14. The latest from the LHC

    CERN Multimedia

    CERN Bulletin

    2010-01-01

    The setting-up to prepare the LHC for running with nominal ramp rates and with bunch trains instead of single-bunch injection have continued over the last two weeks. The goal is to reduce the machine filling time and increase its luminosity. Running with bunch trains requires the careful setting-up of crossing angles in order to avoid unwanted collisions on either side of the experiments.   The technical target for 2010 in terms of bunch spacing in the trains is 150 ns, which corresponds to a physical distance of about 45 m. This target will be progressively reduced next year to eventually attain the nominal value of 25 ns, equivalent to a distance of about 7.5 m between two bunches in the trains. Following initial setting-up last week, this week tests were made to check the size of the crossing angle needed to avoid parasitic collisions when 150 ns trains are injected into the machine, and to measure the aperture with the nominal crossing angle –at injection – of 170 micro radi...

  15. Latest news from the LHC

    CERN Multimedia

    CERN Bulletin

    2010-01-01

    Over the past two weeks the LHC operations team has focused on pushing the LHC’s performance into new territory in terms of stored beam power. Moving to 25 bunches per beam with almost nominal bunch intensities at the end of July implied operation with a stored energy in each beam of more than 1 MJ. This corresponds to the current record for stored beam energy in existing hadron accelerators (e.g. CERN’s SPS and Fermilab’s Tevatron) and it marks an energy regime where a sudden loss of beam or operational errors can result in serious damage to equipment: an energy of 1 MJ is sufficient to melt 2 kg of copper. Extreme care and a thorough optimization of all operational procedures are therefore required in making this important transition in the machine’s performance.   The focus of the past two weeks has been on optimizing the operational procedures and the machine protection systems, with the aim of gaining experience with the reliability and reproducibility of...

  16. The latest from the LHC

    CERN Multimedia

    2009-01-01

    The LHC will run with an energy of 3.5 TeV per beam when it starts up in November this year. The 80 K resistance measurements on the copper stabilizer of the superconducting busbars were completed in the remaining sectors, Sectors 8-1 and 2-3. No abnormally high resistance measurements were found, indicating that no further repairs are necessary for safe running. Detailed analysis of the resistance data from the entire ring determined a safe initial energy of 3.5 TeV per beam. Once a significant data sample has been collected and the operations team has gained experience in running the machine, the energy will be taken towards 5 TeV per beam. More information is available in the recent press release http://press.web.cern.ch/press/PressReleases/Releases2009/PR13.09E.html. Following the helium leaks into the insulation vacuum in Sectors 2-3 and 8-1 (see previous update) the cause of the leak in Sector 2-3 has been confirmed as the flexible hose. This has now been replaced...

  17. Deep penetrating brain injury with 20 years asymptomatic survival. Case report

    International Nuclear Information System (INIS)

    Buczek, M.; Pieninski, A.

    1993-01-01

    Authors report the case of penetrating injury of the head with large metallic fragment embedded to the brain with 20 years asymptomatic survival. Patient sustained head injury during work, 20 years ago and for these period of time was not aware of having foreign body intracranially with excellent general condition and no signs of neurological deficit. Metal nail was detected incidentally by plain skull X-ray films( and subsequent CT scan) during routine procedures when patient was admitted for surgical procedure. In our opinion presented case is uncommon because of asymptomatic course. Most of penetrating head injuries are considered as life threatening due to sudden onset, severe general patient condition and possible deterioration according to the type of injury and extent of cerebral destruction. For those reasons earliest possible neurosurgical treatment is recommended. We emphasize the role of debridement for most of brain penetration injuries. (author)

  18. Testing Benefits Transfer of Forest Recreation Values over a 20-year time Horizon

    DEFF Research Database (Denmark)

    Zandersen, Marianne; Termansen, Mette; Jensen, F.S.

    2007-01-01

    We conduct a functional benefit transfer over 20 years of total willingness to pay based on car-borne forest recreation in 52 forests, using a mixed logit specification of a random utility model and geographic information systems to allow heterogeneous preferences across the population and for he......We conduct a functional benefit transfer over 20 years of total willingness to pay based on car-borne forest recreation in 52 forests, using a mixed logit specification of a random utility model and geographic information systems to allow heterogeneous preferences across the population...... and for heterogeneity over space. Results show that preferences for some forest attributes, such as species diversity and age, as well as transport mode have changed significantly over the period. Updating the transfer model with present total demand for recreation improves the error margins by an average of 282......%. Average errors of the best transfer model remain 25%....

  19. Paraurethral Leiomyoma in a 20 Year-old Woman: A Case Report

    Directory of Open Access Journals (Sweden)

    Emily Adams-Piper

    2016-01-01

    Full Text Available We present the case of a 20 year-old woman with a vulvar mass, found to be a paraurethral leiomyoma. She subsequently underwent supermedial-approach paraurethral mass excision, distal urethral reconstruction and cystourethroscopy. Paraurethral leiomyoma make up approximately five percent of urethral tumors. This case depicts the presentation and treatment of a paraurethral leiomyoma in one of the youngest women reported in the literature.

  20. Radial Artery as a Coronary Artery Bypass Conduit: 20-Year Results.

    Science.gov (United States)

    Gaudino, Mario; Tondi, Paolo; Benedetto, Umberto; Milazzo, Valentina; Flore, Roberto; Glieca, Franco; Ponziani, Francesca Romana; Luciani, Nicola; Girardi, Leonard N; Crea, Filippo; Massetti, Massimo

    2016-08-09

    There is a lack of evidence for the choice of the second conduit in coronary surgery. The radial artery (RA) is a possible option, but few data on very-long-term outcomes exist. This study describes 20-year results of RA grafts used for coronary artery bypass grafting and the effects of RA removal on forearm circulation. We report the results of the prospective 20-year follow-up of the first 100 consecutive patients who received the RA as a coronary bypass conduit at our institution. Follow-up was 100% complete. There were 64 deaths, 23 (35.9%) from cardiovascular causes. Kaplan-Meier 20-year survival was 31%. Of the 36 survivors, 33 (91.6%) underwent RA graft control at a mean of 19.0 ± 2.5 years after surgery. The RA was found to be patent in 24 cases (84.8% patency). In the overall population, probability of graft failure at 20 years was 19.0 ± 0.2% for the left internal thoracic artery (ITA), 25.0 ± 0.2% for the RA, and 55.0 ± 0.2% for the saphenous vein (p = 0.002 for RA vs. saphenous vein, 0.11 for RA vs. ITA, and p 90%, but not location of distal anastomosis, significantly influenced long-term RA graft patency. No patients reported hand or forearm symptoms. The ulnar artery diameter was increased in the operated arm (2.44 ± 0.43 mm vs. 2.01 ± 0.47 mm; p 90% stenosis. RA harvesting does not lead to hand or forearm symptoms, even at a very-long-term follow-up. Copyright © 2016 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

  1. Brand Extensions: A Qualitative Meta-Analysis Of 20 Years Of Marketing Research

    OpenAIRE

    Elise Prosser; Melissa St. James

    2011-01-01

    Brand extensions, or new product introductions under an existing brand name, have become increasingly popular over the past 20 years. Marketers tout brand extensions as enjoying higher market share and profitability than launching new brand names that require exorbitant advertising expenditures (Smith & Park 1992). According to some estimates, brand extensions account for more than 90% of new product introductions in some categories (Volckner & Sattler 2002). However, one study found that 27%...

  2. Wood, the indigenous energy source. 1100 plants built in 20 years, all of them 'Swiss made'

    International Nuclear Information System (INIS)

    Wahlen, B.

    1999-01-01

    The company HOBAG Brienz, Ltd., specialised in the field of automatic wood-burning plants, continuously developed its unique system over the past 20 years and has more than 1100 satisfied clients in Switzerland as well as in foreign countries. It is equally dealing with log boilers, wood chip boilers, or pellet boilers. Nowadays, the company is seen as the market leader for modern, full automatic log-burning plants and wood conditioning equipment including containers for logs or wood chips

  3. Horizontal inequality in education and wealth in Tanzania: A 20-year perspective

    OpenAIRE

    Maliti, Emmanuel

    2016-01-01

    This study uses five series of demographic and health surveys to answer the question: 'Is horizontal inequality in education and wealth increasing or decreasing in the 20-year interval between 1991 and 2010?'. Horizontal inequality in education attainment has been moving in waves; however, there was an invested U-shaped trend where inequality increased between 2004 and 2007 before a declining trend in recent years. Unlike the fluctuating trends of the overall horizontal inequality in educatio...

  4. The latest development of EAST neutral beam injector

    International Nuclear Information System (INIS)

    Hu Chundong; Xu Yongjian

    2014-01-01

    As the first full superconducting non-circular cross section Tokomak in the world, EAST is used to explore the forefront physics and engineering issues on the construction of Tokomak fusion reactor. Neutral beam injection has been recognized as one of the most effective means for plasma heating. According to the research plan of the EAST physics experiment, a set of neutral beam injector (4∼8 MW, 10∼100 s)will be built and operational in 2014. The paper presents the latest development of EAST neutral beam injector and the latest experiment results of long pulse beam extraction and high power beam extraction are reported, those results show that all targets reach or almost reach the design targets. All these will lay a solid foundation for the achievement of plasma heating and current drive for EAST in 2014. (authors)

  5. Supersymmetry searches with ATLAS: overview and latest results

    CERN Multimedia

    CERN. Geneva

    2013-01-01

    Despite the absence of experimental evidence, weak scale supersymmetry remains one of the best motivated and studied Standard Model extensions. The ATLAS experiment searches for signs of supersymmetry in a large variety of signatures involving events with abnormal production of missing transverse momentum, jets, leptons, photons, third generation fermions, gauge bosons or massive long-lived particles. The talk presents the latest results obtained in these searches.

  6. Latest development in project site radwaste treatment facility (SRTF) Sanmen

    International Nuclear Information System (INIS)

    Mennicken, K.; Lohmann, P.

    2015-01-01

    Westinghouse Electric Germany GmbH (WEG) was successful in being awarded a contract as to the planning, delivery, installation and commissioning of radwaste treatment systems for the AP1000 units at Sanmen site, PR China. Operational low and intermediate level radioactive waste will be processed in the Site Radwaste Treatment Facility (SRTF). This paper explains the latest developments of the project, especially the experience with customer-hired Chinese planning partners, installation companies and Customer operating personnel. (authors)

  7. Characterizing Adult Sleep Behavior Over 20 Years-The Population-Based Doetinchem Cohort Study.

    Science.gov (United States)

    Zomers, Margot L; Hulsegge, Gerben; van Oostrom, Sandra H; Proper, Karin I; Verschuren, W M Monique; Picavet, H Susan J

    2017-07-01

    To describe sleep duration patterns of adults over a 20-year period; to compare sociodemographic, lifestyle, and health characteristics across these patterns; and to relate the patterns to sleep quality. The study population consisted of 3695 adults aged 20 to 59 years at baseline. Five measurements of self-reported sleep duration were used to compose seven patterns from 1987 to 2012: persistent short (≤6 hours), moderate (7-8 hours), or long (≥9 hours) sleep duration and several changing patterns (varying and became short, moderate, or long sleepers). Multinomial logistic regression analyses were used to compare characteristics across sleep duration patterns. About 56% of the adults had persistent moderate sleep duration over 20 years. This group had a better sleep quality than the other groups. Of the adults who changed in their sleep duration (40%), 43% became a short sleeper. Sleep duration patterns that deviate from persistent moderate sleep duration were associated with physical inactivity during leisure time (odds ratios [ORs] and 95% confidence intervals [95% CIs] varied between 1.26 [1.04-1.53] and 1.58 [1.06-2.37]) and with poor self-rated health (ORs [95% CIs] varied between 1.50 [1.20-1.87] and 2.15 [1.48-3.12]). Nearly half of the adults did not have persistent moderate sleep duration over a 20-year period and more than one-sixth became short sleeper. This is reason for concern considering the adverse health status associated with short and long sleep duration. Leisure-time physical activity is a potential important target to prevent unfavorable changes in sleep duration over the life course. © Sleep Research Society 2017. Published by Oxford University Press [on behalf of the Sleep Research Society].

  8. A 20 year retrospective histomorphological analysis of juvenile soft tissue tumors

    Directory of Open Access Journals (Sweden)

    Odokuma Emmanuel Igho

    2016-01-01

    Full Text Available Introduction: Soft tissue tumours (STT are defined traditionally as mesenchymal proliferations that occur in the extra-.skeletal nonepithelial tissues of the body excluding viscera, meninges and lymphoreticular system. These tumours occur in children where they may result in severe debilitating disease. This study was therefore aimed at determining the age, gender and site distribution of soft tissue tumours in the young. Materials and Methods: The records of all pathology consultations during the 20 year period from (1990-2010, from the Department of Morbid Anatomy/Histopathology, University of Benin Teaching Hospital from birth to 20 years, were utilized for this study. The lesions were standardized in accordance with the world health organization (WHO classification. Permission for this study was obtained from the UBTH ethics committee (protocol number ADM/E22/A/VOL.VII/142. Results: A total of 139 lesions were recorded, 72 males and 67 females with a male/female ratio of 1.1:1. Benign tumours constituted 113(81% while malignant tumours accounted for 26(19%. This study demonstrated that, nerve sheath tumours and vascular tumours accounted for 25% of STT in children followed by adipocytic tumours 22%, skeletal muscle tumours 17%, fibrohistiocytic tumours 7%, fibroblastic tumours 5%, and perivascular tumours 1% respectively. Majority of these tumours were located in the head and lower extremities with fewer in the upper extremities and trunk. These lesions were predominant in females of the older age group (10-20 years unlike in their male counterparts. Conclusion: This study has shown that benign soft tissue tumours are more prevalent than the malignant varieties in juveniles.

  9. Reports of child sexual abuse of boys and girls: Longitudinal trends over a 20-year period in Victoria, Australia.

    Science.gov (United States)

    Mathews, Ben; Bromfield, Leah; Walsh, Kerryann; Cheng, Qinglu; Norman, Rosana E

    2017-04-01

    Although prevalence studies show girls are more frequently sexually abused than boys, a significant proportion of boys also experience child sexual abuse (CSA). The challenges for public policy are amplified for boys due to less developed public and professional sensitisation to boys' experiences, conceptions of masculinity, and less research on boys including into reporting trends and outcomes. We conducted a 20-year longitudinal time-trend analysis of government data to identify reporting trends and report outcomes for CSA in Victoria, Australia from 1993 to 2012. We stratified by child gender and reporter status. Results indicate a new sensitisation to CSA, especially for boys, although this trend was not stable. Marked change occurred in the last five years, likely influenced by major social and political events. Comparison over time revealed that from 1993 to 2012, the rate of reporting of boys increased 2.6-fold whereas there was a 1.5-fold increase for girls. Comparing genders, with regards to rate of reporting, in 1993, the sex ratio of girls to boys was 2:1, while by 2012 this ratio changed to 1.14:1. Reports by police and other mandated reporters accounted for the majority of the increase in reports over the 20-year period, suggesting unequal sensitisation. Positive report outcomes (i.e. substantiations, findings of harm, and referral to services) increased twelve-fold for boys, and nearly five-fold for girls, indicating the increased levels of reports were based in actual clinical need. Most of this increase occurred from 2009 to 2012, influenced by a compound of social, political and agency-related factors. Copyright © 2017 Elsevier Ltd. All rights reserved.

  10. 20-year follow-up study of Danish HHT patients-survival and causes of death

    DEFF Research Database (Denmark)

    Kjeldsen, Anette; Aagaard, Katrine Saldern; Tørring, Pernille Mathiesen

    2016-01-01

    in the TGF-β pathway which is responsible for angiogenesis. Modulations of angiogenesis may influence cancer rates. The objective of the study was to evaluate 20-year survival according to HHT subtype, as well as to evaluate differences in causes of death comparing HHT patients and controls. We also wanted......BACKGROUND: Hereditary Haemorrhagic Telangiectasia (HHT) is a dominantly inheritable disorder, with a wide variety of clinical manifestations due to presence of multiple arteriovenous manifestations. The most common mutations are found in HHT1 (ENG) and HHT2 (ACVRL1) patients, causing alterations...

  11. Cultural Industries and Policy In Mexico and Canada After 20 Years of NAFTA

    OpenAIRE

    Gómez, Rodrigo; Muñoz Larroa, Argelia

    2014-01-01

    The main objective of this article is to present an analysis of 20 years of the North America Free Trade Agreement (NAFTA) in the area of cultural policies, specifically, those related to cultural industries. Our main focus is to compare the positions that the Canadian and Mexican governments have taken vis-à-vis the world's number-one audiovisual power, the United States. Within this scenario, we have spotlighted the Mexican case. El objetivo principal de este artículo es presentar un aná...

  12. Proliferative myositis of the latissimus dorsi presenting in a 20-year-old male athlete

    LENUS (Irish Health Repository)

    Mc Hugh, N

    2017-08-01

    We describe the case of a 20-year-old rower presenting with an uncommon condition of Proliferative Myositis (PM) affecting the Latissimus Dorsi (LD). PM is a rare, benign tumour infrequently developing in the upper back. Its rapid growth and firm consistency may mistake it for sarcoma at presentation. Therefore, careful multidisciplinary work-up is crucial, and should involve appropriate radiological and histopathological investigations. Here, we propose the aetiology of LD PM to be persistent myotrauma induced by repetitive rowing motions. Symptoms and rate of progression ultimately determine the management which includes surveillance and\\/or conservative resection. There have been no documented cases of recurrence or malignant transformation.

  13. Geostatistical model-based estimates of schistosomiasis prevalence among individuals aged = 20 years in West Africa

    DEFF Research Database (Denmark)

    Schur, Nadine; Hürlimann, Eveline; Garba, Amadou

    2011-01-01

    Schistosomiasis is a water-based disease that is believed to affect over 200 million people with an estimated 97% of the infections concentrated in Africa. However, these statistics are largely based on population re-adjusted data originally published by Utroska and colleagues more than 20 years...... ago. Hence, these estimates are outdated due to large-scale preventive chemotherapy programs, improved sanitation, water resources development and management, among other reasons. For planning, coordination, and evaluation of control activities, it is essential to possess reliable schistosomiasis...

  14. Tuberculous Dactylitis in a 20 Year Old – A Rare Case Report

    Directory of Open Access Journals (Sweden)

    Shefali Goyal

    2017-10-01

    Full Text Available Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis and manifested by formation of tubercles and caseous necrosis in tissues. Tuberculous spondylitis is the most typical form of disease in the musculoskeletal system. Tubercular dactylitis is the tuberculous infection of metacarpal, metatarsal and phalanges and is uncommon. Tuberculous granuloma results in spindle shaped expansion of the short tubular bones, so it is also called as Spina Ventosa (Spina=thorn, Ventosa=full of air. We present a case of 20 year old female with an isolated swelling in the right thumb of 3 months duration.

  15. History of Division 29, 1993-2013: another 20 years of psychotherapy.

    Science.gov (United States)

    Williams, Elizabeth Nutt; Barnett, Jeffrey E; Canter, Mathilda B

    2013-03-01

    The history of Division 29 (Psychotherapy) of the American Psychological Association (APA) from 1993 to 2013 is reviewed. The 20 years of history can be traced via the Division's primary publications (the journal Psychotherapy and its newsletter Psychotherapy Bulletin) as well as the history of those who have served leadership roles in the Division and have won Divisional awards. Several recurring themes emerge related to the Division's articulations of its own identity, the Division's advocacy efforts vis-à-vis the profession and the APA, and the work of the Division on behalf of major social issues (such as disaster relief and the nation's health care).

  16. Employment of persons with spinal cord lesions injured more than 20 years ago

    DEFF Research Database (Denmark)

    Lidal, Ingeborg Beate; Hjeltnes, Nils; Røislien, Jo

    2009-01-01

    PURPOSE: The primary objective was to study factors influencing post-injury employment and withdrawal from work in persons who sustained traumatic spinal cord injury (SCI) more than 20 years ago. A secondary objective was to study life satisfaction in the same patients. METHOD: A cross...... before, and a history of pre-injury medical condition(s). Life satisfaction was better for currently employed participants. CONCLUSION: The study indicates a low employment-rate in persons with SCI, even several years after injury. From the results, we suggest more support, especially to persons of older...

  17. Dyscirculatory encephalopathy in Chernobyl disaster clean-up workers (a 20-year study).

    Science.gov (United States)

    Podsonnaya, I V; Shumakher, G I; Golovin, V A

    2010-05-01

    Results obtained over 20-years of following 536 Chernobyl clean-up workers and 436 control subjects are presented. Dyscirculatory encephalopathy developed more frequently in persons exposed to radiation at age 30 years. As compared with the control group, workers were characterized by early onset of disease, faster progression, stable symptomatology for 5-6 years, and further progression of disease in the form of autonomic dysfunction, psycho-organic syndrome, and epilepsy. Major strokes were also more common in clean-up workers.

  18. The latest Light Robotics breakthroughs - Postdeadline

    DEFF Research Database (Denmark)

    Glückstad, Jesper; Palima, Darwin; Bañas, Andrew

    Contemporary nanoscopy provides functionalities, not only for observing life science on the smallest scales but also for actively reaching into and manipulating at subcellular levels. This post-deadline contribution describes the latest generation of 3D-printed micro-tools for enabling light-acti......-activated robotics on sub-diffraction scales: Light Robotics....

  19. Latest Surprises from Mira the Wonderful

    Science.gov (United States)

    Karovska, Margarita; Marengo, Massimo; Wood, Brian

    We report the latest results from our long-term study of Mira A and its companion Mira B. These include a study of the dust environment in mid-IR wavelengths (Marengo et al. 2001), and of the accretion processes in the Mira AB interacting system (Wood, Karovska, and Raymond 2002).

  20. Bibliometric analysis of global environmental assessment research in a 20-year period

    Energy Technology Data Exchange (ETDEWEB)

    Li, Wei, E-mail: weili@bnu.edu.cn; Zhao, Yang

    2015-01-15

    Based on the samples of 113,468 publications on environmental assessment (EA) from the past 20 years, we used a bibliometric analysis to study the literature in terms of trends of growth, subject categories and journals, international collaboration, geographic distribution of publications, and scientific research issues. By applying thresholds to network centralities, a core group of countries can be distinguished as part of the international collaboration network. A frequently used keywords analysis found that the priority in assessment would gradually change from project environmental impact assessment (EIA) to strategic environmental assessment (SEA). Decision-theoretic approaches (i.e., environmental indicator selection, life cycle assessment, etc.), along with new technologies and methods (i.e., the geographic information system and modeling) have been widely applied in the EA research field over the past 20 years. Hot spots such as “biodiversity” and “climate change” have been emphasized in current EA research, a trend that will likely continue in the future. The h-index has been used to evaluate the research quality among countries all over the world, while the improvement of developing countries' EA systems is becoming a popular research topic. Our study reveals patterns in scientific outputs and academic collaborations and serves as an alternative and innovative way of revealing global research trends in the EA research field.

  1. Acute mastoiditis in a Norwegian population: a 20 year retrospective study.

    Science.gov (United States)

    Vassbotn, Flemming S; Klausen, Olav G; Lind, Ola; Moller, Per

    2002-02-25

    We have retrospectively examined the nature of acute mastioditis (in western Norway) during a 20 year period (1980-2000). Sixty-one cases of AM were identified in 57 patients with a mean age of 3.6 years. We found no significant change in the incidence of AM during the last 20 years. Seven patients were treated solely with intravenous antibiotics and myringotomies. Fifty patients also underwent cortical mastoidectomy, four cases with bilateral surgery. Antibiotic treatment was given to 31 of the patients before admission to hospital and this group had a significant longer duration of symptoms (12.4 days) compared to untreated patients (7.3 days). Streptococcus pneumoniae was the most common organism recovered from patient cultures. Surgery was found to correlate to patients with retroauricular fluctuation or to children with at least two of the three clinical signs: protrusion of the ear, retroauricular oedema and swelling of the ear canal. Our data show that clinical examination only reveal 50% of the cases with surgically proven retroauricular subperiostal abscess. We therefore recommend a CT scan of patients treated conservatively.

  2. [TRENDS OF PERMANENT PACEMAKER IMPLANTATION IN A SINGLE CENTER OVER A 20-YEAR PERIOD].

    Science.gov (United States)

    Antonelli, Dante; Ilan, Limor Bushar; Freedberg, Nahum A; Feldman, Alexander; Turgeman, Yoav

    2015-05-01

    To review the changes in permanent pacemaker implantation indications, pacing modes and patients' demographics over a 20-year period. We retrospectively retrieved data on patients who underwent first implantation of the pacemaker between 1-1-1991 and 31-12-2010. One thousand and nine (1,009) patients underwent a first pacemaker implantation during that period; 535 were men (53%), their mean age was 74.6±19.5 years; the highest rate of implanted pacemaker was in patients ranging in age from 70-79 years, however there was an increasing number of patients aged over 80 years. The median survival time after initial pacemaker implantation was 8 years. Syncope was the most common symptom (62.5%) and atrioventricular block was the most common electrocardiographic indication (56.4%) leading to pacemaker implantation. There was increased utilization of dual chamber and rate responsive pacemakers over the years. There was no difference regarding mode selection between genders. Pacemaker implantation rates have increased over a 20-year period. Dual chamber replaced most of the single ventricular chamber pacemaker and rate responsive pacemakers became the norm. The data of a small volume center are similar to those reported in pacemaker surveys of high volume pacemaker implantation centers. They confirm adherence to the published guidelines for pacing.

  3. Male breast cancer: 20-year survival data for post-mastectomy radiotherapy.

    Science.gov (United States)

    Eggemann, Holm; Ignatov, Atanas; Stabenow, Roland; von Minckwitz, Gunter; Röhl, Friedrich Wilhelm; Hass, Peter; Costa, Serban-Dan

    2013-08-01

    The goal of this population-based study was to determine the impact of post-mastectomy radiation therapy on long-term overall survival (OS) of male patients with breast cancer. We investigated 20-year OS rates of 664 patients diagnosed with primary stage I-III breast cancer in former East Germany between 1970 and 1989. Patients had a radical mastectomy with axillary lymph node dissection without systemic adjuvant therapy. Median follow-up time was 26.2 years (range 19-38 years). 52.4% of the patients had post-mastectomy radiotherapy. Radiotherapy showed different effects in each stage group after 20 years. Whereas there was an OS trend for radiotherapy to harm patients with stage I disease (hazard ratio (HR) 1.45; 95% confidence interval (CI) 0.98-2.15; p = 0.065), radiotherapy showed no benefit in patients with stage II disease (HR 0.82; 95% CI 0.62-1.1; p = 0.15). There was a significant survival benefit for patients with stage III disease receiving radiotherapy (HR 0.60; 95% CI 0.41-0.88; p = 0.008). Post-mastectomy radiotherapy is associated with longer OS in male patients with stage III breast cancer. Male breast cancer patients at stages I and II do not seem to benefit from radiotherapy, but obsolete irradiation techniques might explain adverse long-term effects in earlier stages.

  4. Longitudinal Analysis of Adiponectin through 20-Year Type 1 Diabetes Duration.

    Science.gov (United States)

    LeCaire, Tamara J; Palta, Mari

    2015-01-01

    Little information exists on the trajectory and determinants of adiponectin, a possible insulin sensitizer and marker for inflammation and endothelial function, across the duration of type 1 diabetes. The Wisconsin Diabetes Registry Study followed an incident cohort ≤ 30 years of age when diagnosed with type 1 diabetes during 1987-1992 up to 20-year duration. Adiponectin was concurrently and retrospectively (from samples frozen at -80 °C) measured for those participating in a 20-year exam (n = 304), during 2007-2011. Adiponectin levels were higher in females, declined through adolescence, and increased with age thereafter. Lower levels were associated with greater body weight and waist circumference and with higher insulin dose, especially at longer diabetes durations. Higher levels were associated with higher HbA1c and, at longer durations, with higher albumin-creatinine ratio. Adiponectin levels showed consistency within individuals that was not explained by these factors. We conclude that markers for insulin resistance are associated with lower adiponectin, and markers for potential microvascular complications are associated with higher adiponectin. The previously reported relationship with HbA1c remains largely unexplained. Additional individual specific factors likely also influence adiponectin level. The relationship between adiponectin and urinary protein excretion may enable identification of those predisposed to kidney disease earlier in type 1 diabetes.

  5. Longitudinal Analysis of Adiponectin through 20-Year Type 1 Diabetes Duration

    Directory of Open Access Journals (Sweden)

    Tamara J. LeCaire

    2015-01-01

    Full Text Available Little information exists on the trajectory and determinants of adiponectin, a possible insulin sensitizer and marker for inflammation and endothelial function, across the duration of type 1 diabetes. The Wisconsin Diabetes Registry Study followed an incident cohort ≤30 years of age when diagnosed with type 1 diabetes during 1987–1992 up to 20-year duration. Adiponectin was concurrently and retrospectively (from samples frozen at −80°C measured for those participating in a 20-year exam (n=304, during 2007–2011. Adiponectin levels were higher in females, declined through adolescence, and increased with age thereafter. Lower levels were associated with greater body weight and waist circumference and with higher insulin dose, especially at longer diabetes durations. Higher levels were associated with higher HbA1c and, at longer durations, with higher albumin-creatinine ratio. Adiponectin levels showed consistency within individuals that was not explained by these factors. We conclude that markers for insulin resistance are associated with lower adiponectin, and markers for potential microvascular complications are associated with higher adiponectin. The previously reported relationship with HbA1c remains largely unexplained. Additional individual specific factors likely also influence adiponectin level. The relationship between adiponectin and urinary protein excretion may enable identification of those predisposed to kidney disease earlier in type 1 diabetes.

  6. Managing type 1 diabetes: trends and outcomes over 20 years in the Wisconsin Diabetes Registry cohort.

    Science.gov (United States)

    Palta, Mari; LeCaire, Tamara

    2009-08-01

    The Wisconsin Diabetes Registry Study is a Wisconsin cohort of patients with type 1 diabetes, who were diagnosed in 1987-1992 and actively followed. The study provides patients and health care professionals with better prognostic information and helps identify aspects of diabetes management that need improvement. To describe diabetes management and acute and chronic complications from the time of diagnosis. All incident cases diagnosed at age <30 in 28 counties were eligible and 590 enrolled. A baseline interview, blood sample kits, biannual/annual questionnaires and study examinations at 4, 7, 9, 14, and 20 years duration were administered. Diabetes management indicators, general health, and acute and chronic complications. Glycemic control was poor in adolescence, but improved with age. A high percentage of individuals do not meet treatment standards for blood pressure and lipid profile. Self-reported health deteriorated with age, and body mass index was similar to that of the general US population. Chronic complications were present at 15-20 years, but tended to be relatively mild. There is room for improvement in diabetes management, especially in meeting goals for blood pressure and lipid profile. Nonetheless, individuals with type 1 diabetes can be offered a more optimistic prognosis than in the past.

  7. Vocal fold immobility: a longitudinal analysis of etiology over 20 years.

    Science.gov (United States)

    Rosenthal, Laura H Swibel; Benninger, Michael S; Deeb, Robert H

    2007-10-01

    To determine the current etiology of vocal fold immobility, identify changing trends over the last 20 years, and compare results to historical reports. The present study is a retrospective analysis of all patients seen within a tertiary care institution between 1996 and 2005 with vocal fold immobility. The results were combined with a previous study of patients within the same institution from 1985 through 1995. Results were compared to the literature. The medical records of all patients assigned a primary or additional diagnostic code for vocal cord paralysis were obtained from the electronic database. Eight hundred twenty-seven patients were available for analysis (435 from the most recent cohort), which is substantially larger than any reported series to date. Vocal fold immobility was most commonly associated with a surgical procedure (37%). Nonthyroid surgeries (66%), such as anterior cervical approaches to the spine and carotid endarterectomies, have surpassed thyroid surgery (33%) as the most common iatrogenic causes. These data represent a change from historical figures in which extralaryngeal malignancies were considered the major cause of unilateral immobility. Thyroidectomy continues to cause the majority (80%) of iatrogenic bilateral vocal fold immobility and 30% of all bilateral immobility. This 20-year longitudinal assessment revealed that the etiology of unilateral vocal fold immobility has changed such that there has been a shift from extralaryngeal malignancies to nonthyroid surgical procedures as the major cause. Thyroid surgery remains the most common cause of bilateral vocal fold immobility.

  8. Simulation of 20-year deterioration of acrylic IOLs using severe accelerated deterioration tests.

    Science.gov (United States)

    Kawai, Kenji; Hayakawa, Kenji; Suzuki, Takahiro

    2012-09-20

    To investigate IOL deterioration by conducting severe accelerated deterioration testing of acrylic IOLs. Department of Ophthalmology, Tokai University School of Medicine Methods: Severe accelerated deterioration tests performed on 7 types of acrylic IOLs simulated 20 years of deterioration. IOLs were placed in a screw tube bottle containing ultra-pure water and kept in an oven (100°C) for 115 days. Deterioration was determined based the outer appearance of the IOL in water and under air-dried conditions using an optical microscope. For accelerated deterioration of polymeric material, the elapse of 115 days was considered to be equivalent to 20 years based on the Arrhenius equation. All of the IOLs in the hydrophobic acrylic group except for AU6 showed glistening-like opacity. The entire optical sections of MA60BM and SA60AT became yellowish white in color. Hydrophilic acrylic IOL HP60M showed no opacity at any of the time points examined. Our data based on accelerated testing showed differences in water content to play a major role in transparency. There were differences in opacity among manufacturers. The method we have used for determining the relative time of IOL deterioration might not represent the exact clinical setting, but the appearance of the materials would presumably be very similar to that seen in patients.

  9. Bibliometric analysis of global environmental assessment research in a 20-year period

    International Nuclear Information System (INIS)

    Li, Wei; Zhao, Yang

    2015-01-01

    Based on the samples of 113,468 publications on environmental assessment (EA) from the past 20 years, we used a bibliometric analysis to study the literature in terms of trends of growth, subject categories and journals, international collaboration, geographic distribution of publications, and scientific research issues. By applying thresholds to network centralities, a core group of countries can be distinguished as part of the international collaboration network. A frequently used keywords analysis found that the priority in assessment would gradually change from project environmental impact assessment (EIA) to strategic environmental assessment (SEA). Decision-theoretic approaches (i.e., environmental indicator selection, life cycle assessment, etc.), along with new technologies and methods (i.e., the geographic information system and modeling) have been widely applied in the EA research field over the past 20 years. Hot spots such as “biodiversity” and “climate change” have been emphasized in current EA research, a trend that will likely continue in the future. The h-index has been used to evaluate the research quality among countries all over the world, while the improvement of developing countries' EA systems is becoming a popular research topic. Our study reveals patterns in scientific outputs and academic collaborations and serves as an alternative and innovative way of revealing global research trends in the EA research field

  10. Older adults' health and late-life drinking patterns: a 20-year perspective.

    Science.gov (United States)

    Moos, Rudolf H; Brennan, Penny L; Schutte, Kathleen K; Moos, Bernice S

    2010-01-01

    This study focused on the associations between older adults' health-related problems and their late-life alcohol consumption and drinking problems. A sample of 719 late-middle-aged community residents (55-65 years old at baseline) participated in a survey of health and alcohol consumption and this survey was followed 10 years and 20 years later. Health-related problems increased and alcohol consumption and drinking problems declined over the 20-year interval. Medical conditions, depressive symptoms, medication use, and acute health events were associated with a higher likelihood of abstinence; acute health events were also associated with less alcohol consumption. In contrast, reliance on alcohol to reduce pain was linked to more alcohol consumption. Moreover, an individual's overall health burden and reliance on alcohol to reduce pain were associated with more drinking problems. Reliance on alcohol to reduce pain potentiated the association between health burden, alcohol consumption and drinking problems. Older adults who have more health problems and rely on alcohol to manage pain are at elevated risk for drinking problems. Health care providers should target high-risk older adults, such as those who drink to reduce pain, for screening and brief interventions to help them identify new ways to cope with pain and curtail their drinking.

  11. A 20-Year High-Resolution Wave Resource Assessment of Japan with Wave-Current Interactions

    Science.gov (United States)

    Webb, A.; Waseda, T.; Kiyomatsu, K.

    2016-02-01

    Energy harvested from surface ocean waves and tidal currents has the potential to be a significant source of green energy, particularly for countries with extensive coastlines such as Japan. As part of a larger marine renewable energy project*, The University of Tokyo (in cooperation with JAMSTEC) has conducted a state-of-the-art wave resource assessment (with uncertainty estimates) to assist with wave generator site identification and construction in Japan. This assessment will be publicly available and is based on a large-scale NOAA WAVEWATCH III (version 4.18) simulation using NCEP and JAMSTEC forcings. It includes several key components to improve model skill: a 20-year simulation to reduce aleatory uncertainty, a four-nested-layer approach to resolve a 1 km shoreline, and finite-depth and current effects included in all wave power density calculations. This latter component is particularly important for regions near strong currents such as the Kuroshio. Here, we will analyze the different wave power density equations, discuss the model setup, and present results from the 20-year assessment (with a focus on the role of wave-current interactions). Time permitting, a comparison will also be made with simulations using JMA MSM 5 km winds. *New Energy and Industrial Technology Development Organization (NEDO): "Research on the Framework and Infrastructure of Marine Renewable Energy; an Energy Potential Assessment"

  12. Validity of dietary recall over 20 years among California Seventh-day Adventists.

    Science.gov (United States)

    Fraser, G E; Lindsted, K D; Knutsen, S F; Beeson, W L; Bennett, H; Shavlik, D J

    1998-10-15

    Past dietary habits are etiologically important to incident disease. Yet the validity of such measurements from the previous 10-20 years is poorly understood. In this study, the authors correlated food frequency results that were obtained in 1994-1995 but pertained to recalled diet in 1974 with the weighted mean of five random 24-hour dietary recalls obtained by telephone in 1974. The subjects studied were 72 Seventh-day Adventists who lived within 30 miles of Loma Linda, California; had participated in a 1974 validation study; were still alive; and were willing to participate again in 1994. A method was developed to allow correction for random error in the reference data when these data had differentially weighted components. The results showed partially corrected correlation coefficients of greater than 0.30 for coffee, whole milk, eggs, chips, beef, fish, chicken, fruit, and legumes. Higher correlations on average were obtained when the food frequencies were scored simply 1-9, reflecting the nine frequency categories. The 95% confidence intervals for 15 of the 28 correlations excluded zero. Incorporation of portion size information was unhelpful. The authors concluded that in this population, data recalled from 20 years ago should be treated with caution but, for a number of important foods, that the degree of validity achieved approached that obtained when assessing current dietary habits.

  13. PROBLEM UNACCOMPANIED MINORS IN THE 20 YEARS OF THE TWENTIETH CENTURY (NIZHNY NOVGOROD PROVINCE

    Directory of Open Access Journals (Sweden)

    Natalia Vasilyevna Bystrovа

    2015-01-01

    Full Text Available In the article the scientific, historical and socio-pedagogical bases of juvenile delinquency in the Nizhny Novgorod region in the context of Russia's historical and educational space. The causes of homelessness among children from 1917 to 1930.: The First World War, revolution, civil war, the policy of «war communism».The dynamics of the state in social and legal protection of minors in the period.Goal Is to determine the scientific, historical and socio-pedagogical bases of juvenile delinquency problem in the 20 years of the twentieth century (the Nizhny Novgorod region.Method or the methodology of work Implementing the principles of scientific and historicism, used for general historical science methods (identification, analysis, synthesis, study of archival and published materials, concrete historical, theoretical and system analysis, also found their application specific methods inherent historical and theoretical research: comparative comparative, historical situational, historical, genetic, specific historical, textual analysis.Results Suggested and scientifically substantiated system characteristic juvenile delinquency in the 20 years of the twentieth century in the Nizhny Novgorod region in the changing socio-political sphere in Russia.Practical implications The result is of obvious interest to educators, sociologists conducting research question juvenile delinquency.

  14. Outcome of radioiodine-131 therapy in hyperfunctioning thyroid nodules: a 20 years' retrospective study.

    Science.gov (United States)

    Ceccarelli, Claudia; Bencivelli, Walter; Vitti, Paolo; Grasso, Lucia; Pinchera, Aldo

    2005-03-01

    To investigate the risk of hypothyroidism after radioiodine (131I) treatment for hyperfunctioning thyroid nodules. Retrospective analysis of patients treated with 131I for hyperfunctioning thyroid nodules and followed up for a maximum of 20 years. A total of 346 patients treated with 131I in the years 1975-95, for a single hyperfunctioning nodule. Hypothyroidism was defined as TSH levels > 3.7 mU/l. Kaplan-Meier survival analysis was used to analyse permanence of euthyroidism after 131I. A stepwise Cox proportional hazard model was used to identify factors influencing the progression to hypothyroidism. The cumulative incidence of hypothyroidism was 7.6% at 1 year, 28% at 5 years, 46% at 10 years and 60% at 20 years. Age (P thyroid and nodule size, thyroid status at diagnosis and degree of extranodular thyroid parenchymal suppression had no influence. In hyperthyroid patients with partial parenchymal suppression, however, previous MMI treatment was the most important prognostic factor (P hyperfunctioning nodule are hypothyroid. Factors increasing the risk of hypothyroidism are age, 131I uptake and MMI pretreatment. The prognostic value of this last factor, however, depends on the degree of suppression of the extranodular thyroid parenchyma at the scan.

  15. 20 years TraumaRegister DGU(®): development, aims and structure.

    Science.gov (United States)

    2014-10-01

    The TraumaRegister DGU(®) organisational and technical development has undergone an evolution process, which started 20 years ago. Currently, the management of the registry is under the management of the "AUC - Academy for Trauma Surgery" (infrastructure) and the "Sektion NIS" (scientific responsibility). The aim of the registry was to establish an inter-hospital quality assessment tool with the option to use the increasing database for scientific evaluations of acute care. Year after year and most recently with the obligatory participation of certified hospitals the number of participating hospitals has grown as well as the registered cases per annum. Recently, even hospitals from other countries joined the registry too. Starting with six German hospitals and 260 cases in 1993, 20 years later more than 600 hospitals from eleven countries deliver over 30,000 trauma cases per year resulting in over 150,000 reported cases until 2013. In this article a historical perspective is presented of the evolution and current status of the TraumaRegister DGU(®). Copyright © 2014 Elsevier Ltd. All rights reserved.

  16. The National Diabetes Education Program at 20 Years: Lessons Learned and Plans for the Future.

    Science.gov (United States)

    Siminerio, Linda M; Albright, Ann; Fradkin, Judith; Gallivan, Joanne; McDivitt, Jude; Rodríguez, Betsy; Tuncer, Diane; Wong, Faye

    2018-02-01

    The National Diabetes Education Program (NDEP) was established to translate findings from diabetes research studies into clinical and public health practice. Over 20 years, NDEP has built a program with partnership engagement that includes science-based resources for multiple population and stakeholder audiences. Throughout its history, NDEP has developed strategies and messages based on communication research and relied on established behavior change models from health education, communication, and social marketing. The program's success in continuing to engage diverse partners after 20 years has led to time-proven and high-quality resources that have been sustained. Today, NDEP maintains a national repository of diabetes education tools and resources that are high quality, science- and audience-based, culturally and linguistically appropriate, and available free of charge to a wide variety of audiences. This review looks back and describes NDEP's evolution in transforming and communicating diabetes management and type 2 diabetes prevention strategies through partnerships, campaigns, educational resources, and tools and identifies future opportunities and plans. © 2018 by the American Diabetes Association.

  17. Publication Trends in Acupuncture Research: A 20-Year Bibliometric Analysis Based on PubMed.

    Science.gov (United States)

    Ma, Yan; Dong, Ming; Zhou, Kehua; Mita, Carol; Liu, Jianping; Wayne, Peter M

    2016-01-01

    Acupuncture has become popular and widely practiced in many countries around the world. Despite the large amount of acupuncture-related literature that has been published, broader trends in the prevalence and scope of acupuncture research remain underexplored. The current study quantitatively analyzes trends in acupuncture research publications in the past 20 years. A bibliometric approach was used to search PubMed for all acupuncture-related research articles including clinical and animal studies. Inclusion criteria were articles published between 1995 and 2014 with sufficient information for bibliometric analyses. Rates and patterns of acupuncture publication within the 20 year observational period were estimated, and compared with broader publication rates in biomedicine. Identified eligible publications were further analyzed with respect to study type/design, clinical condition addressed, country of origin, and journal impact factor. A total of 13,320 acupuncture-related publications were identified using our search strategy and eligibility criteria. Regression analyses indicated an exponential growth in publications over the past two decades, with a mean annual growth rate of 10.7%. This compares to a mean annual growth rate of 4.5% in biomedicine. A striking trend was an observed increase in the proportion of randomized clinical trials (RCTs), from 7.4% in 1995 to 20.3% in 2014, exceeding the 4.5% proportional growth of RCTs in biomedicine. Over the 20 year period, pain was consistently the most common focus of acupuncture research (37.9% of publications). Other top rankings with respect to medical focus were arthritis, neoplasms/cancer, pregnancy or labor, mood disorders, stroke, nausea/vomiting, sleep, and paralysis/palsy. Acupuncture research was conducted in 60 countries, with the top 3 contributors being China (47.4%), United States (17.5%), and United Kingdom (8.2%). Retrieved articles were published mostly in complementary and alternative medicine (CAM

  18. Factitious aortic dissection leading to thoracotomy in a 20-year-old man.

    Science.gov (United States)

    Chambers, Elise; Yager, Joel; Apfeldorf, William; Camps-Romero, Eduardo

    2007-01-01

    A 20-year-old man presented to an emergency department with dramatic, sudden-onset, tearing chest pain. He also claimed to have been previously diagnosed with Ehler-Danlos syndrome and a previous Type I aortic dissection (intimal tear of ascending aorta), rapidly increasing his treating physician's suspicion of an emergent aortic dissection. The patient was quickly transferred to a large university hospital, where he underwent a median sternotomy and thoracotomy, with no aortic pathology found on operation and biopsy. After the patient's postoperative recovery, he was treated at a mental health facility, where he remained ambivalent about his psychiatric condition and did not respond well to treatment. This case report describes a unique case of factitious disorder that led to a serious operative intervention and subsequent psychiatric care and assesses factors that might have contributed to his hospital course.

  19. Echoes of Bedford: a 20-year social psychology memoir on participatory action research hatched behind bars.

    Science.gov (United States)

    Fine, Michelle

    2013-11-01

    Responding to Martin Luther King Jr.'s 1968 address at the American Psychological Association calling for a psychology that would educate Whites about racial injustice, this article challenges the widening epistemological gap between those who suffer from inequality and those who conduct social policy research on inequality. In this 20-year memoir on the echoes of a single piece of participatory policy research, Changing Minds: The Impact of College in a Maximum-Security Prison (Fine et al., 2001), readers are invited to explore how deep critical participation by a collaborative team of university and prisoner researchers has facilitated theoretical and methodological complexity, enhanced contextual and construct validity, thickened commitments to ethics and action, and fueled the political sustainability and generalizability of the findings over time and space.

  20. Unintended compositional changes in genetically modified (GM) crops: 20 years of research.

    Science.gov (United States)

    Herman, Rod A; Price, William D

    2013-12-04

    The compositional equivalency between genetically modified (GM) crops and nontransgenic comparators has been a fundamental component of human health safety assessment for 20 years. During this time, a large amount of information has been amassed on the compositional changes that accompany both the transgenesis process and traditional breeding methods; additionally, the genetic mechanisms behind these changes have been elucidated. After two decades, scientists are encouraged to objectively assess this body of literature and determine if sufficient scientific uncertainty still exists to continue the general requirement for these studies to support the safety assessment of transgenic crops. It is concluded that suspect unintended compositional effects that could be caused by genetic modification have not materialized on the basis of this substantial literature. Hence, compositional equivalence studies uniquely required for GM crops may no longer be justified on the basis of scientific uncertainty.

  1. Comparison of methodologies for TMY generation using 20 years data for Athens, Greece

    Energy Technology Data Exchange (ETDEWEB)

    Argiriou, A.; Lykoudis, S.; Kontoyiannidis, S.; Balaras, C.A.; Asimakopoulos, D.; Petrakis, M.; Kassomenos, P. [National Observatory of Athens (Greece). Institute of Meteorology and Physics

    1999-05-01

    The need of accurate Test Reference Years (TRYs) for simulations has been well recognised over the years. Various methods for deriving TRYs have been developed, but their final results can be significantly different. In this paper, the major methodologies reported in literature were applied to 20-year hourly measurements of weather data from Athens, covering the period 1977 to 1996. Seventeen TRYs were produced in total. The basis to select the best performing TRY includes meteorological criteria (inherent in the selection process used by each method) and comparisons of results from various simulations for typical energy systems (i.e. a solar water heater, a building, a large scale solar heating system with interseasonal storage and a photovoltaic system). Based on the results of each simulation exercise, a scoring system was developed and applied. The best performing TRY was found to be the one produced by a modified Festa-Ratto method. (author)

  2. Lung Metastasis of Primary Alveolar Soft-Part Sarcoma Occurring 20 Years after Initial Treatment

    Directory of Open Access Journals (Sweden)

    R. F. Falkenstern-Ge

    2013-01-01

    Full Text Available A 30-year old woman was referred to our center because of suspicion of a primary lung tumor of the right upper lobe. Histological examination of the lung lesion revealed lung metastasis of a previously treated alveolar soft part sarcoma of the musculus vastus medialis of the right femur, which was resected 20 years ago. Alveolar soft-part sarcoma is a rare malignant tumor that occurs most often in the soft tissue of lower limbs. It is a slow-growing malignant soft tissue tumor arising in muscle tissue, usually in young adults. Due to pleural and extensive mediastinal infiltration with bilateral lung metastases, a systemic treatment with chemotherapy doxorubicin and ifosfamide was initiated. Late metastases from previously treated alveolar part sarcoma should be considered in patients with suspicious lung lesions even if surgical treatment was performed a long time ago.

  3. Radon testing in schools in New York State: a 20-year summary

    International Nuclear Information System (INIS)

    Kitto, Michael

    2014-01-01

    For nearly 20 years the Department of Health has conducted programs to assist in the measurement and reduction of indoor radon concentrations in 186 schools located primarily in Zone 1 areas of New York State. Although many schools had few or no rooms containing radon above 148 Bq/m 3 , some rooms had >740 Bq/m 3 and remediation techniques were utilized to reduce exposure. Short-term radon measurements in the schools showed little correlation to basement and first-floor radon results from single-family homes in the towns. - Highlights: • Relatively few schools in New York State have been tested for indoor radon. • We provide a summary of radon-testing results for measured schools. • The radon potential in schools is often less than in local houses. • Short-term measurement results exceeded their long-term counterparts in nearly every case

  4. Ichthyosis hystrix disease or verrucous epidermal nevus (a retrospective analysis of 20-year observation

    Directory of Open Access Journals (Sweden)

    V. D. El'kin

    2017-01-01

    Full Text Available We present a  clinical case of ichthyosis hystrix, a rare genetic ichthyosiform dermatosis. Specifics of the disease are related to the complexity of differential diagnosis and verification of the diagnosis, because clinical manifestation of ichthyosis hystrix is similar with that of verrucous epidermal nevus. Clinical particulars of both nosologies are characterized by bizarre and widespread skin lesions of spicular hyperkeratotic growth, located along Blaschko lines. The exclusive feature of the clinical case described is a  long-term (20 years clinical and laboratory monitoring of the patient. The literature review provides brief information on etiology, pathogenesis, clinical features, differential diagnosis, and pathomorphology of ichthyosis hystrix and verrucous epidermal nevus.

  5. Authorship and characteristics of articles in pharmacy journals: changes over a 20-year interval.

    Science.gov (United States)

    Dotson, Bryan; McManus, Kevin P; Zhao, Jing J; Whittaker, Peter

    2011-03-01

    To our knowledge, no studies have evaluated authorship patterns and characteristics of articles in pharmacy journals. To investigate changes over a 20-year period in authorship and characteristics of articles in pharmacy journals. All articles published in the American Journal of Health-System Pharmacy, The Annals of Pharmacotherapy, and Pharmacotherapy in 1989, 1999, and 2009 were reviewed. Data collected for each article included article type, number of authors, number of physician authors, whether any author was affiliated with a pharmaceutical company, and source of funding. The number of articles included was 574 in 1989, 659 in 1999, and 589 in 2009. The mean number of authors per article increased from 2.5 in 1989 to 2.8 in 1999 and 3.6 in 2009 (p6 authors) increased from 2% in 1989 to 3% in 1999 and 9% in 2009 (pInternational Committee of Medical Journal Editors.

  6. RSIC after 20 years: a look back and a look ahead

    International Nuclear Information System (INIS)

    Maskewitz, B.F.; Roussin, R.W.; Trubev, D.K.

    1983-01-01

    On the occasion of RSIC's 20th anniversary year, this review includes highlights and lessons learned. In June 1963, the first RSIC Newsletter was published, and information analyses procedures and practices were initiated. Evidence indicates that RSIC served for 20 years as the focal point for the exchange and transfer of radiation transport technology and contributed to the advancement of the state of the art. The original concept is found to be sound: operate an information analysis center by collecting, organizing, evaluating, and analyzing all relevant information and making the information available in a form readily useful to scientists and engineers. Computing technology, a computer-based literature information system, and an advisory service remain important elements of the center. Continuing interaction between the center, developers, and users of information products and services has been a key to RSIC success. A look to the future reflects optimism

  7. Large mandibular central odontogenic fibroma documented over 20 years: A case report

    Directory of Open Access Journals (Sweden)

    Patrick Bandura

    Full Text Available Introduction: Central odontogenic fibroma (COF is a rare, benign, slow-growing intraosseous odontogenic tumor, and accounts for 0.1% of all odontogenic tumors. It is often confused with other entities, such as keratocysts, ameloblastomas, and odontogenic myxomas. Complete enucleation followed by curettage is the treatment of choice for COF to ensure the lowest possible chance of recurrence. Case presentation: We report the case of a young Caucasian woman with COF that went undiagnosed for several years despite repeated radiologic examinations. Finally, a massive tumor was surgically removed and the wound was curetted. The specimen was histologically confirmed to be a COF. The patient remains under regular follow-up, and thus far there have been no clinical or radiologic signs of recurrence. Discussion: This rare case of COF, which was documented over a period of 20 years, has helped us to describe the features of this tumor. It also confirms that adequate surgical treatment can lead to impressive bone regeneration in healthy individuals, as evident from the radiologic findings acquired before, during, and after enucleation of the COF in our patient. Our findings also confirm the view that COF has a favorable prognosis regardless of its final size. Conclusion: Early diagnosis is key to successful treatment of COF. The slow but steady increase in the size of a COF with no accompanying symptoms has not been reported previously. To our knowledge, this is the only documented case of a COF that has been under continuous radiologic observation for over 20 years. Keywords: Case report, Central odontogenic fibroma, Long-term, Bone deformation, Follow-up, Tumor enucleation

  8. A scientific forecast on dental research output within the next 20 years using exponential smoothing algorithm

    Directory of Open Access Journals (Sweden)

    Jafar Kolahi

    2017-01-01

    Full Text Available Introduction: To report a scientific forecast of the number of published dental articles in the next 20 years. Materials and Methods: On October 12, 2016, to find all dental articles, PubMed was searched via the query “1800/1/1”[PDAT]: “2015/12/31”[PDAT] AND jsubsetd [text]. Relevant limitations were applied to find dental clinical trials, review articles, and free full-text dental articles. Consequently, all PubMed records were exported to a CSV file. To forecast the future dental research output using existing time-based data, the Exponential Triple Smoothing algorithm was used, which is an advanced machine learning algorithm. Data were analyzed by Microsoft Office Excel 2016. Results: Seventy-five (1940–2015 years of human attempts to publish dental articles were explored and 572490 records were found, from which 27244 (4.75% articles were free full-text, 19238 (3.36% were clinical trials, and 31853 (5.56% were reviews. Researchers will publish 19195 dental articles in 2036, among which 917 (4.77% articles will be clinical trials, 1474 (7.67% will be review articles, and 5482 (28.55% will be free full-text articles. Conclusion: Changes may be because of the quantity of research funds. The number of all types of dental articles will increase with an acceptable rate over the next 20 years. Of more interest, the number of free full-text articles will grow more rapidly than other article types.

  9. Diabetes, glycosuria, and proteinuria in a Japanese cohort followed for 20 years

    International Nuclear Information System (INIS)

    Brodsky, J.B.; Moore, D.F.; Hamilton, H.B.; Kawate, Ryoso.

    1988-07-01

    An analysis of noninsulin-dependent diabetes mellitus, glycosuria, and proteinuria in a Japanese cohort, which has been followed for 20 years, is presented. For the last 14 years of follow-up in Hiroshima, the sex-specific incidence rates of diabetes were approximately constant at 1.2 - 1.4 cases/100 per 2-year interval for males (p > .50) and at 0.5 - 0.6 cases/100 per 2-year interval for females (p > .20). The diagnosis of diabetes depended on first screening for glycosuria and then administering an oral glucose tolerance test only to those with glycosuria. The relatively greater prevalence of glycosuria and diabetes among males has also been noted by others using similar methods. It has been reported elsewhere that if the glucose tolerance test were used to screen for diabetes, the sex difference may not be apparent. The prevalence of diabetes increased over the course of study (p < .001), and the increase was attributed to aging of the cohort. The size of the undiagnosed diabetic population was estimated and the observed prevalence rate was determined to be about 75 % of the actual prevalence rate at the end of 8 years of follow-up and to be about 89 % of the actual prevalence rate at the end of 20 years of follow-up. Proteinuria prevalence was 4.3 % in nondiabetics, 23.5 % in Hiroshima diabetics, and 18.7 % in Nagasaki diabetics. The differences in prevalence rates between nondiabetics and diabetics were highly significant (p < .001). (author)

  10. Outcome of Keratoconus Management: Review of the Past 20 Years' Contemporary Treatment Modalities.

    Science.gov (United States)

    Mandathara, Preeji S; Stapleton, Fiona J; Willcox, Mark D P

    2017-05-01

    To describe the past 20 years' contemporary management modalities for keratoconus (KC) and their outcomes and failures and to propose recommendations in reporting their outcomes. A systematic review of the literature on KC management options for the last 20 years was performed. Original articles that reported the outcome of any form of KC management other than full-thickness or lamellar corneal graft were reviewed to collect information on their outcomes and complications and the level of scientific evidence of the study. A total of 1,147 articles retrieved and of those, 241 satisfied the inclusion criteria, and 41.1% of them were prospective case series. The higher level of evidence studies, that is, randomized controlled trials (RCTs), were limited to only one intervention, that is, corneal collagen cross-linking (CXL). However, the quality of most RCTs was limited because of performance and detection bias. Contact lenses (CLs) remain the mainstream of KC management and were associated with reversible and non-sight-threatening complications. Surgical options such as intracorneal segment implantation and phakic intraocular lens are considered in the visual rehabilitation of CL intolerants, and CXL is the only available option to stop or delay the disease progression. Generally, these surgical procedures are associated with transient inflammatory events and permanent sequelae. The published studies on KC management options varied significantly with respect to the study population, age of participants, severity of KC, clinical outcome measurements, and follow-up period. High-quality longer follow-up RCTs are required to evaluate the long-term effects of KC interventions.

  11. Increased alcohol use over the past 20 years among the oldest old in Sweden

    Directory of Open Access Journals (Sweden)

    Kelfve Susanne

    2014-06-01

    Full Text Available AIMS - Increased alcohol consumption among old people, reported in many countries, will likely present a major challenge to public health and policy in the future. In Sweden, current knowledge about old people’s alcohol consumption is incomplete because of limited historical data and a dearth of nationally representative studies. We describe the frequency of alcohol consumption among the oldest old in Sweden over a 20-year period by sex, age, education, living situation, mobility and Activities of Daily Living. METHODS - We used repeated cross-sectional survey data from the Swedish Panel Study of Living Conditions of the Oldest Old (SWEOLD, conducted in 1992, 2002 and 2011. The samples were nationally representative of the Swedish population aged 77+, with response rates of 95.4%, 84.4% and 86.2% (total n=2007. Self-reported consumption frequency was measured with the question “How often do you drink alcoholic beverages, such as wine, beer or spirits?” RESULTS - Frequency of alcohol consumption increased among the oldest old from 1992 to 2011. The proportion reporting no or less-than-monthly alcohol consumption decreased, whereas the proportion reporting weekly consumption increased. This was true for men, women and most age and educational groups. The period change in consumption frequency was not explained by changes in demographic factors, living situation or functional capacity during the study period. CONCLUSIONS - Alcohol use increased among the oldest old in Sweden during the 20-year study period. More liberal attitudes toward alcohol could contribute to the increased use. The increase in weekly alcohol consumers suggests an increase in the number of older risk consumers.

  12. The latest dictionary of nuclear energy term

    International Nuclear Information System (INIS)

    1996-06-01

    This book is the latest dictionary of nuclear energy term. It deals with explanations of nuclear energy term in alphabetical order. It also lists abbreviation of nuclear energy term. This book contains symbol and unit, radiation units, greek letters, the symbol of for element, the table of an isotope and the periodic table on nuclear power term. It includes glossary of nuclear power in Korean and French and conceptual map about development of nuclear power.

  13. Latest Proterozoic stratigraphy and earth history

    Science.gov (United States)

    Knoll, Andrew H.; Walter, Malcolm R.

    1992-01-01

    Novel biostratigraphic and chemostratigraphic data furnish an improved framework for stratigraphic correlation of the Proterozoic Eon as well as tools for a chronostratigraphic division of the late Proterozoic. It is argued that, in conjunction with geochronometric data, protistan microfossils and isotope geochemistry can furnish a means for an eventual integration of the latest Proterozoic Eon. Attention is given to the emerging methodologies of fossil protists and prokaryotes and of isotopic chemostratigraphy.

  14. Publication of noninferiority clinical trials: changes over a 20-year interval.

    Science.gov (United States)

    Suda, Katie J; Hurley, Anne M; McKibbin, Trevor; Motl Moroney, Susannah E

    2011-09-01

    The primary objective was to evaluate the change in publication rate of noninferiority trials over a 20-year interval (1989-2009). Secondary objectives were to analyze the frequency of noninferiority trials by therapeutic category, the frequency of noninferiority trial publication by journal, the impact factors of the publishing journals, any potential special advantages of the study drug over the control, the funding sources of the trials, pharmaceutical industry affiliation of the authors, and the use of ghostwriters in the creation of manuscripts. Retrospective literature review of 583 articles. PubMed (January 1989-December 2009) and EMBASE (first quarter 1989-fourth quarter 2009) databases. A total of 583 articles of the results of randomized controlled clinical trials with a noninferiority study design that evaluated drug therapies, published in English, between 1989 and 2009, were included in the analysis. A consistent increase was noted in their yearly publication rates, with no trials published in 1989 versus 133 in 2009. One hundred twenty-six articles (21.6%) were in the therapeutic category of infectious diseases, followed by 78 (13.4%) in cardiology. Among the journals identified, The New England Journal of Medicine had the highest publication rate of trials with a noninferiority design, with 29 (5.0%) of the identified trials published in this journal. The median impact factor of the journals publishing noninferiority trials was 4.807 (interquartile range 3.064-7.5). The most common advantage of the study drug over the control was reduced duration of treatment or reduced pill burden (80 studies [22.9%]). A total of 425 trials (72.9%) listed the pharmaceutical industry as the only funding source. Among 369 trials with authors employed by the pharmaceutical industry, 101 (17.3%) disclosed an acknowledgment to an individual, other than those listed as authors, who contributed to writing the manuscript and who was affiliated with a medical information

  15. Comparison of Cardiovascular Risk Factors in Different Areas of Health Care Over a 20-Year Period

    Directory of Open Access Journals (Sweden)

    Thiago Veiga Jardim

    2014-12-01

    Full Text Available Background: Cardiovascular diseases (CVDs are the leading cause of death worldwide. Knowledge about cardiovascular risk factors (CVRFs in young adults and their modification over time are measures that change the risks and prevent CVDs. Objectives: To determine the presence of CVRFs and their changes in different health care professionals over a period of 20 years. Methods: All students of medicine, nursing, nutrition, odontology, and pharmacy departments of Federal University of Goiás who agreed to participate in this study were evaluated when they started their degree courses and 20 years afterward. Questionnaires on CVRFs [systemic arterial hypertension (SAH, diabetes mellitus, dyslipidemia, and family history of early CVD, smoking, alcohol consumption, and sedentarism] were administered. Cholesterol levels, blood sugar levels, blood pressure, weight, height, and body mass index were determined. The Kolmogorov-Smirnov test was used to evaluate distribution, the chi-square test was used to compare different courses and sexes, and the McNemar test was used for comparing CVRFs. The significance level was set at a p value of < 0.05. Results: The first stage of the study included 281 individuals (91% of all the students, of which 62.9% were women; the mean age was 19.7 years. In the second stage, 215 subjects were reassessed (76% of the initial sample, of which 59.07% were women; the mean age was 39.8 years. The sample mostly consisted of medical students (with a predominance of men, followed by nursing, nutrition, and pharmacy students, with a predominance of women (p < 0.05. Excessive weight gain, SAH, and dyslipidemia were observed among physicians and dentists (p < 0.05. Excessive weight gain and SAH and a reduction in sedentarism (p < 0.05 were observed among pharmacists. Among nurses there was an increase in excessive weight and alcohol consumption (p < 0.05. Finally, nutritionists showed an increase in dyslipidemia (p < 0.05. Conclusion

  16. Spermatic feasibility after 20 years of freezing and refreezing: case study

    Directory of Open Access Journals (Sweden)

    Paulo Franco Taitson

    2010-08-01

    Full Text Available The aim of the present work was to study the spermatic feasibility after 20 years of freezing, thawing and refreezing. A young man affected by testicular cancer sought the sperm freezing service. After 20 years, the samples were thawed and frozen again. After two days, thawing and analysis of the material took place. Comparison of the findings showed activity reduction from the first thawing to the fresh semen 59.09%. For the second thawing it was 77.27%. Considering the morphology, first thawing showed a reduction of 44.64% in relation to fresh semen. In the second thawing, the reduction was of 75%. Spermatic motility decreased by 64.28% in relation to fresh semen and 92.85% at the level of second thawing. The patient had gone through in vitro fertilization in 2007, obtaining success in the first one attempt.Este trabalho mostra a viabilidade espermática após 20 anos de congelamento seminal, descongelamento e novo congelamento. Jovem do sexo masculino afetado por câncer testicular procurou o serviço para congelamento de espermatozóides. Após vinte anos, as amostras foram descongeladas e congeladas novamente. Após dois dias, realizou-se um novo descongelamento e análise do material. As comparações dos resultados mostraram uma redução da atividade do primeiro descongelamento ao semen fresco em 59,09%. A partir do segundo descongelamento era de 77,27%. Considerando a morfologia, o primeiro descongelamento mostrou uma redução de 44,64% em relação ao sêmen fresco. No segundo descongelamento, a redução foi de 75%. A motilidade espermática diminuiu 64,28% em relação ao semen fresco e 92,85% a nível do segundo descongelamento. O paciente passou por fertilização in vitro em 2007, obtendo sucesso na primeira tentativa.

  17. A Road Map for America's Water for the Next 20 Years

    Science.gov (United States)

    Lall, U.; Rising, J.; Ho, M. W.; Josset, L.; Allaire, M.; Troy, T.; Devineni, N.; Ruddell, B. L.; Pal, I.

    2016-12-01

    This talk will present a perspective from the America's Water Initiative team that has been discussing the past, present and future of water in America. Paleoclimate reconstructions reveal dramatic inter-annual to decadal structure in the variation in drought across America and provide a backdrop for increasing climate variability expected in the next century. At the same time our water infrastructure ranging from main pipes to dams is aging and in urgent need of renewal. Non-point source pollution from cities and agriculture continues to be a concern and poses a challenge for water supplies. At the same time, there has been progress on water use efficiency, and on the acceptability of water reuse. To assure water, energy and food security for the future, one needs significant investments in water infrastructure of all types, and the cumulative estimates for these run to nearly $3 trillion over the next 20 years. A discussion on infrastructure provision is not complete without a discussion on how use patterns (e.g., where and which crops are grown and how), economic and financial instruments (e.g., insurance associated with the failure of water supply or with flooding, water pricing and trading, capital for construction), regulatory instruments (e.g., standards and policies), technological innovation (e.g., in sensors to improve water utilization in agriculture or pervasive monitoring of drinking and environmental water quality, nanofiltration and resource extraction from waste streams), and governance of water systems. We present for discussion, a proposal for the next 5 and the next 20 years that lays out an adaptive strategy to apprach these issues, and the associated unknowns and challenges that we need to address. The America's Water initiative was launched by Columbia University in partnership with other Universities and representatives from the public and private sectors. A modeling platform that brings together climate, water, agricultural, energy and urban

  18. Evaluation of the Impact of Genetically Modified Cotton After 20 Years of Cultivation in Mexico

    Directory of Open Access Journals (Sweden)

    Martha G. Rocha-Munive

    2018-06-01

    Full Text Available For more than 20 years cotton has been the most widely sown genetically modified (GM crop in Mexico. Its cultivation has fulfilled all requirements and has gone through the different regulatory stages. During the last 20 years, both research-institutions and biotech-companies have generated scientific and technical information regarding GM cotton cultivation in Mexico. In this work, we collected data in order to analyze the environmental and agronomic effects of the use of GM cotton in Mexico. In 1996, the introduction of Bt cotton made it possible to reactivate this crop, which in previous years was greatly reduced due to pest problems, production costs and environmental concerns. Bt cotton is a widely accepted tool for cotton producers and has proven to be efficient for the control of lepidopteran pests. The economic benefits of its use are variable, and depend on factors such as the international cotton-prices and other costs associated with its inputs. So far, the management strategies used to prevent development of insect resistance to GM cotton has been successful, and there are no reports of insect resistance development to Bt cotton in Mexico. In addition, no effects have been observed on non-target organisms. For herbicide tolerant cotton, the prevention of herbicide resistance has also been successful since unlike other countries, the onset of resistance weeds is still slow, apparently due to cultural practices and rotation of different herbicides. Environmental benefits have been achieved with a reduction in chemical insecticide applications and the subsequent decrease in primary pest populations, so that the inclusion of other technologies—e.g., use of non-Bt cotton- can be explored. Nevertheless, control measures need to be implemented during transport of the bolls and fiber to prevent dispersal of volunteer plants and subsequent gene flow to wild relatives distributed outside the GM cotton growing areas. It is still necessary to

  19. Comparison of Cardiovascular Risk Factors in Different Areas of Health Care Over a 20-Year Period

    International Nuclear Information System (INIS)

    Jardim, Thiago Veiga; Sousa, Ana Luiza Lima; Povoa, Thais Rolim; Barroso, Weimar Sebba; Chinem, Brunela; Jardim, Paulo Cesar Veiga

    2014-01-01

    Cardiovascular diseases (CVDs) are the leading cause of death worldwide. Knowledge about cardiovascular risk factors (CVRFs) in young adults and their modification over time are measures that change the risks and prevent CVDs. To determine the presence of CVRFs and their changes in different health care professionals over a period of 20 years. All students of medicine, nursing, nutrition, odontology, and pharmacy departments of Federal University of Goiás who agreed to participate in this study were evaluated when they started their degree courses and 20 years afterward. Questionnaires on CVRFs [systemic arterial hypertension (SAH), diabetes mellitus, dyslipidemia, and family history of early CVD, smoking, alcohol consumption, and sedentarism] were administered. Cholesterol levels, blood sugar levels, blood pressure, weight, height, and body mass index were determined. The Kolmogorov-Smirnov test was used to evaluate distribution, the chi-square test was used to compare different courses and sexes, and the McNemar test was used for comparing CVRFs. The significance level was set at a p value of < 0.05. The first stage of the study included 281 individuals (91% of all the students), of which 62.9% were women; the mean age was 19.7 years. In the second stage, 215 subjects were reassessed (76% of the initial sample), of which 59.07% were women; the mean age was 39.8 years. The sample mostly consisted of medical students (with a predominance of men), followed by nursing, nutrition, and pharmacy students, with a predominance of women (p < 0.05). Excessive weight gain, SAH, and dyslipidemia were observed among physicians and dentists (p < 0.05). Excessive weight gain and SAH and a reduction in sedentarism (p < 0.05) were observed among pharmacists. Among nurses there was an increase in excessive weight and alcohol consumption (p < 0.05). Finally, nutritionists showed an increase in dyslipidemia (p < 0.05). In general, there was an unfavorable progression of CVRFs in the

  20. Comparison of Cardiovascular Risk Factors in Different Areas of Health Care Over a 20-Year Period

    Energy Technology Data Exchange (ETDEWEB)

    Jardim, Thiago Veiga, E-mail: thiagoveiga@cardiol.br; Sousa, Ana Luiza Lima [Liga de Hipertensão Arterial - Universidade Federal de Goiás, Goiânia, GO (Brazil); Povoa, Thais Rolim [Faculdade de Educação Física - Universidade Estadual de Goiás, Goiânia, GO (Brazil); Barroso, Weimar Sebba; Chinem, Brunela; Jardim, Paulo Cesar Veiga [Liga de Hipertensão Arterial - Universidade Federal de Goiás, Goiânia, GO (Brazil)

    2014-12-15

    Cardiovascular diseases (CVDs) are the leading cause of death worldwide. Knowledge about cardiovascular risk factors (CVRFs) in young adults and their modification over time are measures that change the risks and prevent CVDs. To determine the presence of CVRFs and their changes in different health care professionals over a period of 20 years. All students of medicine, nursing, nutrition, odontology, and pharmacy departments of Federal University of Goiás who agreed to participate in this study were evaluated when they started their degree courses and 20 years afterward. Questionnaires on CVRFs [systemic arterial hypertension (SAH), diabetes mellitus, dyslipidemia, and family history of early CVD, smoking, alcohol consumption, and sedentarism] were administered. Cholesterol levels, blood sugar levels, blood pressure, weight, height, and body mass index were determined. The Kolmogorov-Smirnov test was used to evaluate distribution, the chi-square test was used to compare different courses and sexes, and the McNemar test was used for comparing CVRFs. The significance level was set at a p value of < 0.05. The first stage of the study included 281 individuals (91% of all the students), of which 62.9% were women; the mean age was 19.7 years. In the second stage, 215 subjects were reassessed (76% of the initial sample), of which 59.07% were women; the mean age was 39.8 years. The sample mostly consisted of medical students (with a predominance of men), followed by nursing, nutrition, and pharmacy students, with a predominance of women (p < 0.05). Excessive weight gain, SAH, and dyslipidemia were observed among physicians and dentists (p < 0.05). Excessive weight gain and SAH and a reduction in sedentarism (p < 0.05) were observed among pharmacists. Among nurses there was an increase in excessive weight and alcohol consumption (p < 0.05). Finally, nutritionists showed an increase in dyslipidemia (p < 0.05). In general, there was an unfavorable progression of CVRFs in the

  1. CT appearances of unilateral cleft palate 20 years after bone graft surgery

    International Nuclear Information System (INIS)

    Kolbenstvedt, A.; Aaloekken, T.M.

    2002-01-01

    Purpose: To describe CT appearances in patients with unilateral cleft lip and palate (CLP) 20 years after bone graft surgery. Material and Methods: Eighteen consecutive patients with unilateral CLP were examined. All patients had been treated with primary closure, both in infancy and early childhood, supplemented with bone grafting at the age of around 10 years. The CT examination of the upper jaw included a dental CT program. The CT appearances of the cleft side were compared with those of the untreated non-cleft side. Results: Abnormal CT appearances included skew nasal aperture (n=17), nasal septal deviation (n=17), low floor of nasal aperture (n=15) at or towards the cleft side, and deviation of anterior nasal spine towards the non-cleft side (n=18). The posterior part of the bone cleft was visible in all patients, and the dental arch was V-shaped in 8. Conclusion: Although adherence to the present treatment protocol is considered to give satisfactory functional and cosmetic results, certain abnormalities persist. A knowledge of these is a prerequisite for a complete and final evaluation of the surgical and orthodontic regimen. Cleft palate nasal cavity abnormalities CT

  2. National Medicines Policy in retrospective: a review of (almost) 20 years of implementation.

    Science.gov (United States)

    Vasconcelos, Daniela Moulin Maciel de; Chaves, Gabriela Costa; Azeredo, Thiago Botelho; Silva, Rondineli Mendes da

    2017-08-01

    Pharmaceutical services and the formulation of a medicines policy are SUS areas ensured by the organic health care law 8,080/90. Thus, after a widely participative process, involving stakeholders, the National Medicines Policy (NMP) was approved in 1998 by Ordinance 3,916.The NMP presents directives and priorities, aligned with organic health care law, which should guide the federal, states and municipals entities actions to achieve the policy goals. Considering almost 20 years of the NMP, this paper took stock discussed some of the directives in light of the SUS principles. It was not the objective to provide an exhaustive review of all the activities performed during this period. The authors tried to get close to those that have brought advances and dilemmas, with potential risk of regression. Efforts to implement an ambitious agenda applied to pharmaceutical services were identified. This agenda tried to deal with different challenges like the dynamics of the pharmaceutical market and the operation of pharmaceutical services to guarantee the supply of medicines aligned with principles and directives of SUS.

  3. Laurel forest recovery during 20 years in an abandoned firebreak in Tenerife, Canary Islands

    Science.gov (United States)

    Ramón Arévalo, José; Dolores Peraza, María; Álvarez, Carlos; Bermúdez, Alfredo; Domingo Delgado, Juan; Gallardo, Antonio; María Fernández-Palacios, José

    2008-01-01

    This study assessed the recovery of the structure and species composition of a laurel forest in an abandoned firebreak in the Rural Park of Anaga, Tenerife (Canary Islands). We statistically compared values of species richness, density and biovolume between 23 plots in the firebreak and six control plots in natural forest near the firebreak. We evaluated changes in species composition with detrended correspondence analysis (DCA) based on densities and biovolume. Biovolume is increasing significantly along the successional gradient (from 1990 to 2004) but remains less than the values in control plots. Stem densities were significantly lower in control plots than in 2004 plots. Species richness was significantly higher in control plots than in 2004 plots (although there were no differences in values obtained between the first sampling period 6 years after abandonment, and the second sampling 20 years after abandonment). Changes in species richness are significant, but all species present in control plots are also found in the firebreak plots. DCA based on biovolume significantly discriminated control plots from firebreak plots in 1990 (for axis I). Results suggest recovery to a laurel forest is occurring, although more time will be required to reach control plot density and biovolume values. The low intensity of disturbance and a well-conserved forest adjacent to the firebreak favour the recovery of species inside the firebreak. We advise eliminating suckers from all small trees (leaving the bigger stems) to accelerate succession to a vegetation structure similar to that found surrounding the firebreak.

  4. Carbon print: in 20 years, French gained weight. Carbon Newsletter Nr 2

    International Nuclear Information System (INIS)

    Grandjean, Alain; Jancovici, Jean-Marc; Paillat, Emmanuelle; Adam, Julien; Wilmotte, Jean-Yves

    2011-09-01

    This publication proposes another approach (ECO_2 Climat) than a simple rate between direct emissions and population to assess the average carbon emission by a French person: to calculate, not direct emissions made by the country, but emissions necessary to the fabrication of all what is consumed by French people in France, whether this fabrication is made in France or anywhere else. As, with respect to the preceding method, the assessment seems quite good (direct emissions are almost steady whereas population increases, and the individual carbon print therefore decreases), the obtained result is not so flattering. This approach is thus described, and some aspects are highlighted: average individual greenhouse gas emissions, most impacting items (food, and then manufactured products, and individual mobility), evolution of the indicator during the last 20 years, comparison with the national inventory of greenhouse gas emissions. The main variations of emissions between 1990 and 2010 are discussed: energy in housing, food, manufactured products, individual mobility, and services. A brief discussion is proposed in terms of social-professional category. Some ways to face the challenge for a transition towards a low carbon economy are highlighted

  5. Trends in female authorship in research papers on eating disorders: 20-year bibliometric study.

    Science.gov (United States)

    Strand, Mattias; Bulik, Cynthia M

    2018-03-01

    There is a clear gender gap in scientific authorship. Although the proportions of female authors in medicine and psychiatry have increased over the past decades, women are still underrepresented. Aims To analyse authorship gender trends in eating disorder research. First and last author gender in research articles on eating disorders during the period 1997-2016 were assessed in eating disorder specialty journals, high-impact psychiatry journals and high-impact clinical psychology journals. The total number of papers on eating disorders increased substantially over the observation period, although a decrease was observed in high-impact psychiatry journals. Female authorship increased in both specialty journals and high-impact psychiatry journals. Authors were significantly less likely to be female in high-impact psychiatry and clinical psychology journals than in speciality journals. Eating disorder research has been increasingly allocated to specialty journals over the past 20 years. A consistent gender gap between specialty and high-impact journals exists. Declaration of interest C.M.B is a grant recipient from Shire Pharmaceuticals, Inc. and has participated as a member of their scientific advisory board. These positions are unrelated to the content of this article.

  6. 20 YEARS OF PROGRESS IN DENGUE HEMORRHAGIC FEVER AND OTHER ARBOVIRAL DISEASES RESEARCH

    Directory of Open Access Journals (Sweden)

    Sumarmo Poorwo Soedarmo

    2012-09-01

    Full Text Available Throughout the 20 year history of U.S. Naval Medical Research Unit No. 2 Detachment (NAMRU, many viruses and viral diseases have been studied. The greatest emphasis has been in the field of arboviruses, specifically dengue virus, chikungunya virus, and Japanese B encephalitis virus. The initial focus of the work was to define the extent of the threat posed by these viruses. Studies were conducted to determine antibody prevalence, and to determine the etiologies of infectious febrile disease in hospitalized patients. Later the work advanced into more specific areas, especially the entomologic and clinical components of these viruses. Little was known of the incidence or kind of arbovirus infections in Indonesia when NAMRU was established. Previous serological studies had used the cross reactive haemagglutination assay. Green et al. in 1973 provided convincing serological evidence of infections with chikungunya virus and group B arboviruses by using the specific virus neutralization assay. These results demonstrated the need for further studies to isolate the causative agent, to describe the epidemiology, and to investigate the clinical features of the associated disease.

  7. CT appearances of unilateral cleft palate 20 years after bone graft surgery

    Energy Technology Data Exchange (ETDEWEB)

    Kolbenstvedt, A.; Aaloekken, T.M. [Rikshospitalet, Oslo (Norway). Dept. of Radiology; Arctander, K. [Rikshospitalet, Oslo (Norway). Dept. of Plastic Surgery; Johannessen, S. [Inst. of Clinical Dentistry, Oslo (Norway)

    2002-11-01

    Purpose: To describe CT appearances in patients with unilateral cleft lip and palate (CLP) 20 years after bone graft surgery. Material and Methods: Eighteen consecutive patients with unilateral CLP were examined. All patients had been treated with primary closure, both in infancy and early childhood, supplemented with bone grafting at the age of around 10 years. The CT examination of the upper jaw included a dental CT program. The CT appearances of the cleft side were compared with those of the untreated non-cleft side. Results: Abnormal CT appearances included skew nasal aperture (n=17), nasal septal deviation (n=17), low floor of nasal aperture (n=15) at or towards the cleft side, and deviation of anterior nasal spine towards the non-cleft side (n=18). The posterior part of the bone cleft was visible in all patients, and the dental arch was V-shaped in 8. Conclusion: Although adherence to the present treatment protocol is considered to give satisfactory functional and cosmetic results, certain abnormalities persist. A knowledge of these is a prerequisite for a complete and final evaluation of the surgical and orthodontic regimen. Cleft palate nasal cavity abnormalities CT.

  8. BIPM direct on-site Josephson voltage standard comparisons: 20 years of results

    International Nuclear Information System (INIS)

    Solve, Stephane; Stock, Michael

    2012-01-01

    The discovery of the Josephson effect has for the first time given national metrology institutes (NMIs) the possibility of maintaining voltage references which are stable in time. In addition, the introduction in 1990 of a conventional value for the Josephson constant, K J-90 , has greatly improved world-wide consistency among representations of the volt. For 20 years, the Bureau International des Poids et Mesures (BIPM) has conducted an ongoing, direct, on-site key comparison of Josephson voltage standards among NMIs under the denominations BIPM.EM-K10.a (1 V) and BIPM.EM-K10.b (10 V) in the framework of the mutual recognition arrangement (CIPM MRA). The results of 41 comparisons illustrate the consistency among primary voltage standards and have demonstrated that a relative total uncertainty of a few parts in 10 10 is achievable if a few precautions are taken with regard to the measurement set-up. Of particular importance are the grounding, efficient filters and high insulation resistance of the measurement leads, and clean microwave distribution along the propagation line to the Josephson array. This paper reviews the comparison scheme and technical issues that need to be taken into account to achieve a relative uncertainty at the level of a few parts in 10 10 or even a few parts in 10 11 in the best cases. (paper)

  9. The Incidence of Primary Systemic Vasculitis in Jerusalem: A 20-year Hospital-based Retrospective Study.

    Science.gov (United States)

    Nesher, Gideon; Ben-Chetrit, Eli; Mazal, Bracha; Breuer, Gabriel S

    2016-06-01

    The incidence of primary systemic vasculitides varies among different geographic regions and ethnic origins. The aim of this study was to examine the incidence rates of vasculitides in the Jerusalem Jewish population, and to examine possible trends in incidence rates over a 20-year period. The clinical databases of inpatients at the 2 medical centers in Jerusalem were searched for patients with vasculitis diagnosed between 1990-2009. Individual records were then reviewed by one of the authors. The significance of trends in incidence rates throughout the study period was evaluated by Pearson correlation coefficient. The average annual incidence rate of polyarteritis nodosa was 3.6/million adults (95% CI 1.6-4.7). Incidence rates did not change significantly during this period (r = 0.39, p = 0.088). The incidence of granulomatosis with polyangiitis (GPA) was 4.1 (2.2-5.9) for the whole period, during which it increased significantly (r = 0.53, p Jerusalem are in the lower range of global incidence rates. While GPA and MPA incidence are increasing, GCA incidence is decreasing.

  10. Structural changes and degradation of Red Latosols under different management systems for 20 years

    Directory of Open Access Journals (Sweden)

    João Tavares Filho

    2014-08-01

    Full Text Available Soils are the foundation of terrestrial ecosystems and their role in food production is fundamental, although physical degradation has been observed in recent years, caused by different cultural practices that modify structures and consequently the functioning of soils. The objective of this study was to evaluate possible structural changes and degradation in an Oxisol under different managements for 20 years: no-tillage cultivation with and without crop rotation, perennial crop and conventional tillage, plus a forested area (reference. Initially, the crop profile was described and subsequently, 10 samples per management system and forest soil were collected to quantify soil organic matter, flocculation degree, bulk density, and macroporosity. The results indicated structural changes down to a soil depth of 50 cm, with predominance of structural units ∆μ (intermediate compaction level under perennial crop and no-tillage crop rotation, and of structural units ∆ (compacted under conventional tillage and no-tillage. The soil was increasingly degraded in the increasing order: forest => no-tillage crop rotation => perennial crop => no-tillage without crop rotation => conventional tillage. In all managements, the values of organic matter and macroporosity were always below and bulk density always above those of the reference area (forest and, under no-tillage crop rotation and perennial crop, the flocculation degree was proportionally equal to that of the reference area.

  11. Multilevel learning in the adaptive management of waterfowl harvests: 20 years and counting

    Science.gov (United States)

    Johnson, Fred A.; Boomer, G. Scott; Williams, Byron K.; Nichols, James D.; Case, David J.

    2015-01-01

    In 1995, the U.S. Fish and Wildlife Service implemented an adaptive harvest management program (AHM) for the sport harvest of midcontinent mallards (Anas platyrhynchos). The program has been successful in reducing long-standing contentiousness in the regulatory process, while integrating science and policy in a coherent, rigorous, and transparent fashion. After 20 years, much has been learned about the relationship among waterfowl populations, their environment, and hunting regulations, with each increment of learning contributing to better management decisions. At the same time, however, much has been changing in the social, institutional, and environmental arenas that provide context for the AHM process. Declines in hunter numbers, competition from more pressing conservation issues, and global-change processes are increasingly challenging waterfowl managers to faithfully reflect the needs and desires of stakeholders, to account for an increasing number of institutional constraints, and to (probabilistically) predict the consequences of regulatory policy in a changing environment. We review the lessons learned from the AHM process so far, and describe emerging challenges and ways in which they may be addressed. We conclude that the practice of AHM has greatly increased an awareness of the roles of social values, trade-offs, and attitudes toward risk in regulatory decision-making. Nevertheless, going forward the waterfowl management community will need to focus not only on the relationships among habitat, harvest, and waterfowl populations, but on the ways in which society values waterfowl and how those values can change over time. 

  12. A prospective 20-year longitudinal follow-up of dementia in persons with Down syndrome.

    Science.gov (United States)

    McCarron, M; McCallion, P; Reilly, E; Dunne, P; Carroll, R; Mulryan, N

    2017-09-01

    To examine dementia characteristics, age at onset and associated co-morbidities in persons with Down syndrome. A total of 77 people with Down syndrome aged 35 years and older were followed up from 1996 to 2015. The diagnosis of dementia was established using the modified ICD 10 Criteria and a combination of objective and informant-based tests. Cognitive tests included the Test for Severe Impairment and the Down Syndrome Mental Status Examination; adaptive behaviour was measured using the Daily Living Skills Questionnaire, and data from the Dementia Questionnaire for People with Intellectual Disabilities have been available since 2005. Over the 20-year period, 97.4% (75 of 77) persons developed dementia with a mean age of dementia diagnosis of 55 years (SD = 7.1, median = 56 years). Clinical dementia was associated with cognitive and function decline and seizure activity. Risk for dementia increased from 23% in those aged 50 years to 80% in those aged 65 years and above. There were no differences by level of ID. The previously reported high risk levels for dementia among people with Down syndrome were confirmed in this data as was the relationship with late onset epilepsy. The value of the instruments utilised in tracking decline and helping to confirm diagnosis is further highlighted. © 2017 MENCAP and International Association of the Scientific Study of Intellectual and Developmental Disabilities and John Wiley & Sons Ltd.

  13. Cancer Incidence and Mortality in a Cohort of US Blood Donors: A 20-Year Study

    International Nuclear Information System (INIS)

    Vahidnia, F.; Busch, M. P.; Custer, B.; Hirschler, N. V.; Chinn, A.; Agapova, M.; Busch, M. P.; Custer, B.

    2013-01-01

    Blood donors are considered one of the healthiest populations. This study describes the epidemiology of cancer in a cohort of blood donors up to 20 years after blood donation. Records from donors who participated in the Retroviral Epidemiology Donor Study (REDS, 1991-2002) at Blood Centers of the Pacific (BCP), San Francisco, were linked to the California Cancer Registry (CCR, 1991-2010). Standardized incidence ratios (SIR) were estimated using standard US 2000 population, and survival analysis used to compare all-cause mortality among donors and a random sample of non donors with cancer from CCR. Of 55,158 eligible allogeneic blood donors followed-up for 863,902 person-years, 4,236 (7.7%) primary malignant cancers were diagnosed. SIR in donors was 1.59 (95% CI = 1.54,1.64). Donors had significantly lower mortality (adjusted HR = 0.70, 95% CI = 0.66-0.74) compared with non donor cancer patients, except for respiratory system cancers (adjusted HR = 0.93, 95% CI = 0.82-1.05). Elevated cancer incidence among blood donors may reflect higher diagnosis rates due to health seeking behavior and cancer screening in donors. A “healthy donor effect” on mortality following cancer diagnosis was demonstrated. This population-based database and sample repository of blood donors with long-term monitoring of cancer incidence provides the opportunity for future analyses of genetic and other bio markers of cancer

  14. Cre-Lox Neurogenetics: 20 Years of Versatile Applications in Brain Research and Counting….

    Science.gov (United States)

    Tsien, Joe Z

    2016-01-01

    Defining and manipulating specific neurons in the brain has garnered enormous interest in recent years, because such an approach is now widely recognized as crucial for deepening our understanding of how the brain works. When I started exploring the Cre-loxP recombination for brain research in the early 1990s, it was written off as a dead-end project by a young fool. Yet over the past 20 years, Cre-lox recombination-mediated neurogenetics has emerged as one of the most powerful and versatile technology platforms for cell-specific gene knockouts, transgenic overexpression, Brainbow imaging, neural pathway tracing with retrovirus and CLARITY, chemical genetics, and optogenetics. Its popularity and greater utility in neuroscience research is also largely thanks to the NIH's bold Blueprint for Neuroscience Research Initiative to launch several Cre-driver resource projects, as well as individual laboratories and private research organizations. With newly-discovered, genetically-encoded molecules that are capable of responding to sonar and magnetic stimulation, for sonogenetics or magnetogenetics, respectively, or detecting rapid voltage changes in neurons, Cre-lox neurogenetics will continue to aid brain research for years to come.

  15. An Analysis of 20 Years of Space Weathering Effects on the Boeing 376 Spacecraft

    Science.gov (United States)

    Frith, James; Anz-Meador, Phillip; Cowardin, Heather; Buckalew, Brent; Lederer, Susan

    2015-01-01

    The Boeing HS-376 spin stabilized spacecraft was a popular design that was launched continuously into geosynchronous orbit starting in 1980, with the last launch occurring in 2003. Over 50 of the HS-376 buses were produced to fulfill a variety of different communication missions for countries all over the world. The design of the bus is easily approximated as a telescoping cylinder that is covered with solar cells and an Earth-facing antenna that is despun at the top of the cylinder. The similarity in design and the number of spacecraft launched over a long period of time make the HS-376 a prime target for studying the effects of solar weathering on solar panels as a function of time. A selection of primarily non-operational HS-376 spacecraft launched over a 20-year time period were observed using the United Kingdom Infrared Telescope on Mauna Kea and multi-band, near-infrared photometry produced. Each spacecraft was observed for an entire night cycling through ZYJHK filters and time-varying colors produced to compare near-infrared color as a function of launch date. The resulting analysis shown here may help in the future to set launch date constraints on the parent object of unidentified debris objects or other unknown spacecraft.

  16. Combined visual and motor evoked potentials predict multiple sclerosis disability after 20 years.

    Science.gov (United States)

    Schlaeger, Regina; Schindler, Christian; Grize, Leticia; Dellas, Sophie; Radue, Ernst W; Kappos, Ludwig; Fuhr, Peter

    2014-09-01

    The development of predictors of multiple sclerosis (MS) disability is difficult due to the complex interplay of pathophysiological and adaptive processes. The purpose of this study was to investigate whether combined evoked potential (EP)-measures allow prediction of MS disability after 20 years. We examined 28 patients with clinically definite MS according to Poser's criteria with Expanded Disability Status Scale (EDSS) scores, combined visual and motor EPs at entry (T0), 6 (T1), 12 (T2) and 24 (T3) months, and a cranial magnetic resonance imaging (MRI) scan at T0 and T2. EDSS testing was repeated at year 14 (T4) and year 20 (T5). Spearman rank correlation was used. We performed a multivariable regression analysis to examine predictive relationships of the sum of z-transformed EP latencies (s-EPT0) and other baseline variables with EDSST5. We found that s-EPT0 correlated with EDSST5 (rho=0.72, pdisability in MS. © The Author(s) 2014.

  17. 20 years of speleothem paleoluminescence records of environmental changes: an overview

    Directory of Open Access Journals (Sweden)

    Shopov Yavor Y.

    2004-12-01

    Full Text Available This paper discusses advance of the research on Speleothem paleoluminescence Records of Environmental Changes after it have been first introduced by the author 20 years ago.It is demonstrated that most of the progress in this field was made in result of the operation of the International Program “Luminescence of Cave Minerals” of the commission on Physical Chemistry and Hydrogeology of Karst of UIS of UNESCO.Potential, resolution and limitations of high resolution luminescence speleothem proxy records of Paleotemperature, Solar Insolation, Solar Luminosity, Glaciations, Sea Level advances, Past Precipitation, Plants Populations, Paleosoils, Past Karst Denudation, Chemical Pollution, Geomagnetic field and Cosmic Rays Flux variations, Cosmogenic Isotopes production and Supernova Eruptions in the Past, Advances of Hydrothermal Waters, and Tectonic Uplift are discussed.It is demonstrated that speleothems allow extremely high resolution (higher than in any other paleoclimatic terrestrial archives and long duration of records. Some speleothems can be used as natural climatic stations for obtaining of quantitative proxy records of Quaternary climates with annual resolution.

  18. Family cohesion and posttraumatic intrusion and avoidance among war veterans: a 20-year longitudinal study.

    Science.gov (United States)

    Zerach, Gadi; Solomon, Zahava; Horesh, Danny; Ein-Dor, Tsachi

    2013-02-01

    The bi-directional relationships between combat-induced posttraumatic symptoms and family relations are yet to be understood. The present study assesses the longitudinal interrelationship of posttraumatic intrusion and avoidance and family cohesion among 208 Israeli combat veterans from the 1982 Lebanon War. Two groups of veterans were assessed with self-report questionnaires 1, 3 and 20 years after the war: a combat stress reaction (CSR) group and a matched non-CSR control group. Latent Trajectories Modeling showed that veterans of the CSR group reported higher intrusion and avoidance than non-CSR veterans at all three points of time. With time, there was a decline in these symptoms in both groups, but the decline was more salient among the CSR group. The latter also reported lower levels of family cohesion. Furthermore, an incline in family cohesion levels was found in both groups over the years. Most importantly, Autoregressive Cross-Lagged Modeling among CSR and non-CSR veterans revealed that CSR veterans' posttraumatic symptoms in 1983 predicted lower family cohesion in 1985, and lower family cohesion, in turn, predicted posttraumatic symptoms in 2002. The findings suggest that psychological breakdown on the battlefield is a marker for future family cohesion difficulties. Our results lend further support for the bi-directional mutual effects of posttraumatic symptoms and family cohesion over time.

  19. Trends in referral to a single encopresis clinic over 20 years.

    Science.gov (United States)

    Fishman, Laurie; Rappaport, Leonard; Schonwald, Alison; Nurko, Samuel

    2003-05-01

    To compare the characteristics of children with encopresis referred to a single encopresis clinic over the course of 20 years, including symptoms, previous diagnostic and therapeutic interventions, and parental attitudes. A retrospective study was conducted of an encopresis clinic at a tertiary care pediatric hospital. Questionnaires at initial evaluation elicited information about bowel habits, soiling, previous evaluations, previous treatments, and parental attitudes. In 503 children with encopresis, the average age of referral dropped from 115 months during the earliest 5 years to 77 months during the most recent 5 years. Children who had soiling for >3 years before referral decreased from 63% to 12%. The use of barium enema before referral decreased from 14% to 5%, as did psychological evaluation, from 25% to 14%. Previous therapy with enemas decreased from 45% to 27%. Mineral oil use remained at approximately 50%, and 20% of children had no previous treatment. Symptoms at referral and parental attitudes did not change across the years. Children are now referred at an earlier age to our tertiary encopresis clinic. The number of invasive and psychological evaluations has decreased before referral. However, treatment by many primary care providers before the referral has not changed. These data may suggest that pediatricians have increased awareness of encopresis and greater appreciation of its primarily physical rather than psychological nature. Additional studies will be needed to determine how these factors affect outcome.

  20. Computed tomography findings in patients less than 20 years old with lymphoma

    International Nuclear Information System (INIS)

    Borba, Adriana Moreira Viana; Skinner, Luis Flavio

    2007-01-01

    Objective: To describe the general findings of lymphoma and their histological patterns in patients less than 20 years old. Materials And Methods: Twenty-two cases (16 male and 6 female, mean age 11.5 years) from the digital archive of computed tomography at the Cancer Control Center of Hospital Universitario Pedro Ernesto - Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil, were retrospectively analyzed in the period between March 2003 and July 2005. Of these 22 cases, 12 were Hodgkin's and 10 were non-Hodgkin's. Results: Overall, mediastinal lymphadenomegaly was the most frequent finding (59%), with predominance in the Hodgkin's subgroup (75%), followed by hepatosplenomegaly (50%) and cervical and retroperitoneal lymphadenomegaly (27.3%). The Hodgkin's subgroup presented a prevalence of lymphadenopathy, in many lymph node chains, followed by hepatosplenomegaly (50%). One case was found with unilateral tonsillar mass, pulmonary ground-glass opacities, and renal nodules. In the non-Hodgkin's subgroup, the disease was predominantly extranodal, characterized by hepatosplenomegaly (50%), thickening of the intestinal wall (40%), pleural effusion (30%), pulmonary nodule (20%), ascites (10%), pericardial effusion (10%) and mixed bone lesions (10%). Conclusion: Computed tomography is an extremely useful method for detection, staging and follow-up of lymphomas, with alert findings like mediastinal lymphadenopathy, hepatosplenomegaly, unilateral tonsillar mass and thickening of intestinal wall. (author)

  1. Cytogenetic effects of radioiodine therapy: a 20-year follow-up study

    Energy Technology Data Exchange (ETDEWEB)

    Livingston, Gordon K. [Oak Ridge Institute for Science and Education, Radiation Emergency Assistance Center/Training Site, Oak Ridge, TN (United States); Khvostunov, Igor K. [Medical Radiological Research Center, Obninsk, Kaluga Region (Russian Federation); Gregoire, Eric [Institut de Radioprotection et de Surete Nucleaire, PRP-HOM/SRBE/LDB, BP 17, Fontenay aux roses Cedex (France); Barquinero, Joan-Francesc [Universtitat Autonoma de Barcelona, Facultat de Biociencies, Cerdanyola del Valles (Spain); Shi, Lin; Tashiro, Satoshi [Hiroshima University, Department of Cellular Biology, Research Institute for Radiation Biology and Medicine, Hiroshima (Japan)

    2016-05-15

    The purpose of this study was to compare cytogenetic data in a patient before and after treatment with radioiodine to evaluate the assays in the context of biological dosimetry. We studied a 34-year-old male patient who underwent a total thyroidectomy followed by ablation therapy with {sup 131}I (19.28 GBq) for a papillary thyroid carcinoma. The patient provided blood samples before treatment and then serial samples at monthly intervals during the first year period and quarterly intervals for 5 years and finally 20 years after treatment. A micronucleus assay, dicentric assay, FISH method and G-banding were used to detect and measure DNA damage in circulating peripheral blood lymphocytes of the patient. The results showed that radiation-induced cytogenetic effects persisted for many years after treatment as shown by elevated micronuclei and chromosome aberrations as a result of exposure to {sup 131}I. At 5 years after treatment, the micronucleus count was tenfold higher than the pre-exposure frequency. Shortly after the treatment, micronucleus counts produced a dose estimate of 0.47 ± 0.09 Gy. The dose to the patient evaluated retrospectively using FISH-measured translocations was 0.70 ± 0.16 Gy. Overall, our results show that the micronucleus assay is a retrospective biomarker of low-dose radiation exposure. However, this method is not able to determine local dose to the target tissue which in this case was any residual thyroid cells plus metastases of thyroidal origin. (orig.)

  2. Cancer Incidence and Mortality in a Cohort of US Blood Donors: A 20-Year Study

    Science.gov (United States)

    Hirschler, Nora V.; Chinn, Artina; Busch, Michael P.; Custer, Brian

    2013-01-01

    Blood donors are considered one of the healthiest populations. This study describes the epidemiology of cancer in a cohort of blood donors up to 20 years after blood donation. Records from donors who participated in the Retroviral Epidemiology Donor Study (REDS, 1991–2002) at Blood Centers of the Pacific (BCP), San Francisco, were linked to the California Cancer Registry (CCR, 1991–2010). Standardized incidence ratios (SIR) were estimated using standard US 2000 population, and survival analysis used to compare all-cause mortality among donors and a random sample of nondonors with cancer from CCR. Of 55,158 eligible allogeneic blood donors followed-up for 863,902 person-years, 4,236 (7.7%) primary malignant cancers were diagnosed. SIR in donors was 1.59 (95% CI = 1.54,1.64). Donors had significantly lower mortality (adjusted HR = 0.70, 95% CI = 0.66–0.74) compared with nondonor cancer patients, except for respiratory system cancers (adjusted HR = 0.93, 95% CI = 0.82–1.05). Elevated cancer incidence among blood donors may reflect higher diagnosis rates due to health seeking behavior and cancer screening in donors. A “healthy donor effect” on mortality following cancer diagnosis was demonstrated. This population-based database and sample repository of blood donors with long-term monitoring of cancer incidence provides the opportunity for future analyses of genetic and other biomarkers of cancer. PMID:24489545

  3. Cancer Incidence and Mortality in a Cohort of US Blood Donors: A 20-Year Study

    Directory of Open Access Journals (Sweden)

    Farnaz Vahidnia

    2013-01-01

    Full Text Available Blood donors are considered one of the healthiest populations. This study describes the epidemiology of cancer in a cohort of blood donors up to 20 years after blood donation. Records from donors who participated in the Retroviral Epidemiology Donor Study (REDS, 1991–2002 at Blood Centers of the Pacific (BCP, San Francisco, were linked to the California Cancer Registry (CCR, 1991–2010. Standardized incidence ratios (SIR were estimated using standard US 2000 population, and survival analysis used to compare all-cause mortality among donors and a random sample of nondonors with cancer from CCR. Of 55,158 eligible allogeneic blood donors followed-up for 863,902 person-years, 4,236 (7.7% primary malignant cancers were diagnosed. SIR in donors was 1.59 (95% CI = 1.54,1.64. Donors had significantly lower mortality (adjusted HR = 0.70, 95% CI = 0.66–0.74 compared with nondonor cancer patients, except for respiratory system cancers (adjusted HR = 0.93, 95% CI = 0.82–1.05. Elevated cancer incidence among blood donors may reflect higher diagnosis rates due to health seeking behavior and cancer screening in donors. A “healthy donor effect” on mortality following cancer diagnosis was demonstrated. This population-based database and sample repository of blood donors with long-term monitoring of cancer incidence provides the opportunity for future analyses of genetic and other biomarkers of cancer.

  4. [Meeting Report: 20 years after the First International Symposium on hepatitis C virus and related viruses].

    Science.gov (United States)

    Carnero, Elena; Díez, Juana; Fortes, Purificación; Gastaminza, Pablo; Majano, Pedro; Martínez, Miguel Angel; Pérez-del-Pulgar, Sofía; Quer, Josep; López-Labrador, F Xavier

    2013-12-01

    The hepatitis C virus (HCV) was discovered by the team of Michael Houghton at Chiron Corporation in 1989 and the first symposium on HCV and related viruses was held in Venice, Italy, shortly after, in 1992. This conference was organized to advance knowledge on what then was a mysterious virus responsible for most cases of «non-A, non-B» hepatitis. During the 20 years since the first conference, the scientific quality of presentations has steadily increased, together with the tremendous advances in basic and clinical research and epidemiology. What started as a small conference on a new virus, about which there were very few data, has today become a first-in-class congress: a meeting place for basic researchers, clinicians, epidemiologists, public health experts, and industry members to present the most important advances and their application to HCV treatment and control. The nineteenth HCV symposium was held in September 2012, once again in Venice. Copyright © 2013 Elsevier España, S.L. and AEEH y AEG. All rights reserved.

  5. Visualization on the Web of 20 Years of Crop Rotation and Wildlife Co-Evolutions

    Science.gov (United States)

    Plumejeaud-Perreau, Christine; Poitevin, Cyril; Bretagnolle, Vincent

    2018-05-01

    The accumulation of evidences of the effects of intensive agricultural practices against wildlife fauna and flora, and biodiversity in general, has been largely published in scientific papers (Tildman, 1999). However, data serving as sup-port to their conclusions are often kept hidden behind research institutions. This paper presents a data visualization sys-tem opened on the Web allowing citizens to get a comprehensive access to data issued from such kind of research institution, collected for more than 20 years. The Web Information System has been thought in order to ease the comparison of data issues from various databases describing the same object, the agricultural landscape, at different scales and through different observation devices. An interactive visualization is proposed in order to check co-evolution of fauna and flora together with agricultural practices. It mixes aerial orthoimagery produced since 1950 with vectorial data showing the evolutions of agricultural parcels with those of a few sentinel species such as the Montagu's harrier. This is made through a composition of maps, charts and time lines, and specific tools for comparison. A particular concern is given to the observation effort bias in order to show meaningful statistical aggregates.

  6. The structure of late-life depressive symptoms across a 20-year span: a taxometric investigation.

    Science.gov (United States)

    Holland, Jason M; Schutte, Kathleen K; Brennan, Penny L; Moos, Rudolf H

    2010-03-01

    Past studies of the underlying structure of depressive symptoms have yielded mixed results, with some studies supporting a continuous conceptualization and others supporting a categorical one. However, no study has examined this research question with an exclusively older adult sample, despite the potential uniqueness of late-life depressive symptoms. In the present study, the underlying structure of late-life depressive symptoms was examined among a sample of 1,289 individuals across 3 waves of data collection spanning 20 years. The authors employed a taxometric methodology using indicators of depression derived from the Research Diagnostic Criteria (R. L. Spitzer, J. Endicott, & E. Robins, 1978). Maximum eigenvalue analyses and inchworm consistency tests generally supported a categorical conceptualization and identified a group that was primarily characterized by thoughts about death and suicide. However, compared to a categorical depression variable, depressive symptoms treated continuously were generally better predictors of relevant criterion variables. These findings suggest that thoughts of death and suicide may characterize a specific type of late-life depression, yet a continuous conceptualization still typically maximizes the predictive utility of late-life depressive symptoms.

  7. Prevalence of dental erosion and association with lifestyle factors in Swedish 20-year olds.

    Science.gov (United States)

    Isaksson, Helén; Birkhed, Dowen; Wendt, Lill-Kari; Alm, Anita; Nilsson, Mats; Koch, Göran

    2014-08-01

    To investigate the prevalence, distribution and severity of dental erosion and its association with lifestyle, oral and general health in young adults. Four hundred and ninety-four individuals, 20-years of age, participated. Dental erosion in molars and maxillary incisors was evaluated. Caries, plaque and gingivitis were registered. Saliva samples were taken and the subjects were interviewed about behavioural and dietary habits and oral and general health. Body mass index (BMI) was calculated. The individuals were sub-divided into two groups according to the presence and absence of dental erosion: within the group with erosion was a sub-group of individuals with extensive erosion. Of the individuals 25% had no erosion, 75% had erosion and 18% had extensive erosion. Erosion was found in molars in 74% of the individuals and on buccal and palatal surfaces in maxillary incisors in 4% and 7%, respectively. Cupping was seen in 65% of individuals and severe erosion in molars in 1.6%. Compared to subjects with no erosion, those with extensive erosion had a higher consumption of soft drinks (p = 0.05), caries prevalence (p erosion had higher caries prevalence (p erosion. Swedish young adults have a high prevalence of dental erosion, but the level of severe erosion is low. The study disclosed a relationship between dental erosion and behavioural factors, oral health and BMI.

  8. Cina Benteng: The Latest Generations and Acculturation

    Directory of Open Access Journals (Sweden)

    Billy Nathan Setiawan

    2015-05-01

    Full Text Available The aim of this paper was to investigate the acculturation process encountered by the two latest generations of Cina Benteng. A Skype interview was conducted with two young Cina Benteng descents. The analysis was also supported by insightful remark from the parents of the two interviewees. This study discovers that the two generations seem to respond to the acculturation process in different ways. However, although some traditions are no longer relevant to the later generation, their identity as a Chinese descent cannot be easily removed.

  9. Turbomachinery: latest developments in a changing scene

    International Nuclear Information System (INIS)

    1991-01-01

    The contributions to the 1991 European Conference on the latest developments in turbomachinery are presented. The topics covered include: computational fluid dynamics methods applied to the aerodynamics of turbine blades; developments associated with steam turbines and gas turbines; flow patterns for turbine blades; compressor design and development; turbine test facilities; film cooling; heat transfer; theoretical treatment of transonic and unsteady flow; condensation phenomena and wet steam flow; water extraction from steam turbine blades; wetness losses in steam turbines in nuclear power plants and pressure loss reduction; aerodynamic instabilities arising from governing valves in Pressurized Water Reactor steam turbines. (UK)

  10. Continuous Improvement of a Groundwater Model over a 20-Year Period: Lessons Learned.

    Science.gov (United States)

    Andersen, Peter F; Ross, James L; Fenske, Jon P

    2018-04-17

    Groundwater models developed for specific sites generally become obsolete within a few years due to changes in: (1) modeling technology; (2) site/project personnel; (3) project funding; and (4) modeling objectives. Consequently, new models are sometimes developed for the same sites using the latest technology and data, but without potential knowledge gained from the prior models. When it occurs, this practice is particularly problematic because, although technology, data, and observed conditions change, development of the new numerical model may not consider the conceptual model's underpinnings. As a contrary situation, we present the unique case of a numerical flow and trichloroethylene (TCE) transport model that was first developed in 1993 and since revised and updated annually by the same personnel. The updates are prompted by an increase in the amount of data, exposure to a wider range of hydrologic conditions over increasingly longer timeframes, technological advances, evolving modeling objectives, and revised modeling methodologies. The history of updates shows smooth, incremental changes in the conceptual model and modeled aquifer parameters that result from both increase and decrease in complexity. Myriad modeling objectives have included demonstrating the ineffectiveness of a groundwater extraction/injection system, evaluating potential TCE degradation, locating new monitoring points, and predicting likelihood of exceedance of groundwater standards. The application emphasizes an original tenet of successful groundwater modeling: iterative adjustment of the conceptual model based on observations of actual vs. model response. © 2018, National Ground Water Association.

  11. Ecosystem development after mangrove wetland creation: plant-soil change across a 20-year chronosequence

    Science.gov (United States)

    Osland, Michael J.; Spivak, Amanda C.; Nestlerode, Janet A.; Lessmann, Jeannine M.; Almario, Alejandro E.; Heitmuller, Paul T.; Russell, Marc J.; Krauss, Ken W.; Alvarez, Federico; Dantin, Darrin D.; Harvey, James E.; From, Andrew S.; Cormier, Nicole; Stagg, Camille L.

    2012-01-01

    Mangrove wetland restoration and creation efforts are increasingly proposed as mechanisms to compensate for mangrove wetland losses. However, ecosystem development and functional equivalence in restored and created mangrove wetlands are poorly understood. We compared a 20-year chronosequence of created tidal wetland sites in Tampa Bay, Florida (USA) to natural reference mangrove wetlands. Across the chronosequence, our sites represent the succession from salt marsh to mangrove forest communities. Our results identify important soil and plant structural differences between the created and natural reference wetland sites; however, they also depict a positive developmental trajectory for the created wetland sites that reflects tightly coupled plant-soil development. Because upland soils and/or dredge spoils were used to create the new mangrove habitats, the soils at younger created sites and at lower depths (10-30 cm) had higher bulk densities, higher sand content, lower soil organic matter (SOM), lower total carbon (TC), and lower total nitrogen (TN) than did natural reference wetland soils. However, in the upper soil layer (0-10 cm), SOM, TC, and TN increased with created wetland site age simultaneously with mangrove forest growth. The rate of created wetland soil C accumulation was comparable to literature values for natural mangrove wetlands. Notably, the time to equivalence for the upper soil layer of created mangrove wetlands appears to be faster than for many other wetland ecosystem types. Collectively, our findings characterize the rate and trajectory of above- and below-ground changes associated with ecosystem development in created mangrove wetlands; this is valuable information for environmental managers planning to sustain existing mangrove wetlands or mitigate for mangrove wetland losses.

  12. 20 Years of Total and Tropical Ozone Time Series Based on European Satellite Observations

    Science.gov (United States)

    Loyola, D. G.; Heue, K. P.; Coldewey-Egbers, M.

    2016-12-01

    Ozone is an important trace gas in the atmosphere, while the stratospheric ozone layer protects the earth surface from the incident UV radiation, the tropospheric ozone acts as green house gas and causes health damages as well as crop loss. The total ozone column is dominated by the stratospheric column, the tropospheric columns only contributes about 10% to the total column.The ozone column data from the European satellite instruments GOME, SCIAMACHY, OMI, GOME-2A and GOME-2B are available within the ESA Climate Change Initiative project with a high degree of inter-sensor consistency. The tropospheric ozone columns are based on the convective cloud differential algorithm. The datasets encompass a period of more than 20 years between 1995 and 2015, for the trend analysis the data sets were harmonized relative to one of the instruments. For the tropics we found an increase in the tropospheric ozone column of 0.75 ± 0.12 DU decade^{-1} with local variations between 1.8 and -0.8. The largest trends were observed over southern Africa and the Atlantic Ocean. A seasonal trend analysis led to the assumption that the increase is caused by additional forest fires.The trend for the total column was not that certain, based on model predicted trend data and the measurement uncertainty we estimated that another 10 to 15 years of observations will be required to observe a statistical significant trend. In the mid latitudes the trends are currently hidden in the large variability and for the tropics the modelled trends are low. Also the possibility of diverging trends at different altitudes must be considered; an increase in the tropospheric ozone might be accompanied by decreasing stratospheric ozone.The European satellite data record will be extended over the next two decades with the atmospheric satellite missions Sentinel 5 Precursor (launch end of 2016), Sentinel 4 and Sentinel 5.

  13. Osteosarcoma in the anterior chest wall that developed 20 years after postoperative radiotherapy for breast cancer

    International Nuclear Information System (INIS)

    Murata, Mariko; Shoji, Tsuyoshi; Nakayama, Ei; Bando, Toru

    2008-01-01

    Sarcomas are a rare complication of radiotherapy for breast cancer and such patients have a poor prognosis. We report resection of an osteosarcoma in the chest wall that developed 20 years after postoperative radiotherapy for breast cancer. A 57-year-old woman was referred to our department for examination and treatment of an anterior chest wall tumor in April 2007. In September 1986, she had undergone a radical mastectomy and postoperative irradiation and chemotherapy for right breast cancer. In December 2003, she underwent chemotherapy for recurrence of breast cancer which was pointed out on computed tomography involving the pleura and left superior clavicular lymph nodes. In March 2006, follow-up computed tomography of the chest demonstrated the destruction of the sternum, which was diagnosed as recurrence and she was followed with chemotherapy for breast cancer continuously thereafter. In April 2007, because of the developing sternal tumor, excisional biopsy was performed and histopathology indicated sarcoma. In May 2007, resection of the chest wall tumor with the sternum, bilateral clavicles, bilateral first and second ribs, and right partial lung (upper and middle lobe) were performed, and the chest wall defect was reconstructed with a rectus abdominis musculocutaneous free flap. Histopathologically, the tumor was osteosarcoma with margin free. Adjuvant radiotherapy to the breast plays a significant role in preventing local disease recurrence in women treated for breast cancer. However, radiotherapy can induce malignant sarcoma after a latency period of several years. The risk is extremely low for the individual patient, but this disease is aggressive and associated with a poor overall prognosis. Therefore, early detection is necessary for optimal treatment and incisional biopsy is necessary for accurate diagnosis. (author)

  14. Tracking 20 years of compound-to-target output from literature and patents.

    Directory of Open Access Journals (Sweden)

    Christopher Southan

    Full Text Available The statistics of drug development output and declining yield of approved medicines has been the subject of many recent reviews. However, assessing research productivity that feeds development is more difficult. Here we utilise an extensive database of structure-activity relationships extracted from papers and patents. We have used this database to analyse published compounds cumulatively linked to nearly 4000 protein target identifiers from multiple species over the last 20 years. The compound output increases up to 2005 followed by a decline that parallels a fall in pharmaceutical patenting. Counts of protein targets have plateaued but not fallen. We extended these results by exploring compounds and targets for one large pharmaceutical company. In addition, we examined collective time course data for six individual protease targets, including average molecular weight of the compounds. We also tracked the PubMed profile of these targets to detect signals related to changes in compound output. Our results show that research compound output had decreased 35% by 2012. The major causative factor is likely to be a contraction in the global research base due to mergers and acquisitions across the pharmaceutical industry. However, this does not rule out an increasing stringency of compound quality filtration and/or patenting cost control. The number of proteins mapped to compounds on a yearly basis shows less decline, indicating the cumulative published target capacity of global research is being sustained in the region of 300 proteins for large companies. The tracking of six individual targets shows uniquely detailed patterns not discernible from cumulative snapshots. These are interpretable in terms of events related to validation and de-risking of targets that produce detectable follow-on surges in patenting. Further analysis of the type we present here can provide unique insights into the process of drug discovery based on the data it actually

  15. MEST-Tyche will take its dark comets to impact our solar system in 20 years

    Science.gov (United States)

    Cao, Dayong

    2012-03-01

    Tyche has many dark comets like Oort cloud. It went near our solar system every 25-27 million years. It could take its dark comets to impact our earth. Tyche and its dark comet absorb light like a dark light which is a negative black-body radiation. (1) Eddν=-c1dνd^3dνe^c2dνd/Td-1. Among it, Ed: the dark energy, νd: the dark frequence, Td: the dark temperature, c1d,c2d: the constant. So when they go near us, their wave has a against Doppler redshift as 0.000165. And they will inbreak solar system at the rate of 99AU/y, from the distance of 1,500AU and in 20 years. It can cause the broken ozonosphere, the lithosphere to crack, many big activity volcanic and the continental drift. And it can darked the light and colded the climate to the Great Ice Age. Not only it will break our environment by a special ``nuclear explosion'' under low temperature, but also the dark life will change the Genetic code of our life. So it will kill many lives and will produce new life. So it could trigger the Mass Extinction. We can bulid up a new pair of nuclear reactor (include dark nuclear energy) to drive a universal craft and can change the orbit of our earth for evading the impaction. We need a new life-information technology to develop our life and consciousness.

  16. MEDOKADS - A 20 Year's Daily AVHRR Data Series for Analysis of Land Surface Properties

    Science.gov (United States)

    Koslowsky, D.; Billing, H.; Bolle, H.-J.

    2009-04-01

    To derive primary data products from raw AVHRR data, like spectral reflectances or temperatures, it is necessary to correct for sensor degradation and changing hardware specifications, to re-sample the data into a grid of equal pixel size, to perform geographical registration, cloud-screening and normalization for illumination and observation geometry. A data set which resulted from the application of these corrections is the top of the atmosphere Mediterranean Extended One-Km AVHRR Data Set (MEDOKADS) which now covers a period of 20 years. To study land surface processes, the obtained spectral data have to be combined, radiometric corrections for atmospheric effects, emissivity corrections in the case of temperature measurements have to be applied, and the variable over-flight times have to be accounted for. By application of complex evaluation schemes then higher level products are generated, like vegetation indices, surface albedo, and surface energy fluxes. The ultimate goal is to provide the users community with problem-related information. This includes the quantification of changes and the determination of trends. Methods and tools to reach this goal as well as their limitations are discussed. To validate the data, extended field measurements have been performed in which the scaling between local ground measurements and large scale satellite data play a major role. A major problem remains the application of atmospheric corrections because of the not well known variable aerosol content. The supervision of the quality of the derived information leads to the concept of anchor stations at which surface and atmospheric properties should permanently be measured.

  17. Prenatal Diagnosis of Transposition of the Great Arteries over a 20-Year Period: Improved but Imperfect

    Science.gov (United States)

    Escobar-Diaz, Maria C; Freud, Lindsay R; Bueno, Alejandra; Brown, David W; Friedman, Kevin; Schidlow, David; Emani, Sitaram; del Nido, Pedro; Tworetzky, Wayne

    2015-01-01

    Objective To evaluate temporal trends in prenatal diagnosis of transposition of the great arteries with intact ventricular septum (TGA/IVS) and its impact on neonatal morbidity and mortality. Methods Newborns with TGA/IVS referred for surgical management to our center over a 20-year period (1992 – 2011) were included. The study time was divided into 5 four-year periods, and the primary outcome was rate of prenatal diagnosis. Secondary outcomes included neonatal pre-operative status and perioperative survival. Results Of the 340 patients, 81 (24%) had a prenatal diagnosis. Prenatal diagnosis increased over the study period from 6% to 41% (p<0.001). Prenatally diagnosed patients underwent a balloon atrial septostomy (BAS) earlier than postnatally diagnosed patients (0 vs. 1 day, p<0.001) and fewer required mechanical ventilation (56% vs. 69%, p=0.03). There were no statistically significant differences in pre-operative acidosis (16% vs. 26%, p=0.1) and need for preoperative ECMO (2% vs. 3%, p=1.0). There was also no significant mortality difference (1 pre-operative and no post-operative deaths among prenatally diagnosed patients, as compared to 4 pre-operative and 6 post-operative deaths among postnatally diagnosed patients). Conclusion The prenatal detection rate of TGA/IVS has improved but still remains below 50%, suggesting the need for strategies to increase detection rates. The mortality rate was not statistically different between pre- and postnatally diagnosed patients; however, there were significant pre-operative differences with regard to earlier BAS and less mechanical ventilation. Ongoing study is required to elucidate whether prenatal diagnosis confers long-term benefit. PMID:25484180

  18. Recent very high heat stress summers will be the norm within 20 years

    Science.gov (United States)

    Li, C.; Zhang, X.; Zwiers, F. W.

    2017-12-01

    The wet bulb globe temperature (WBGT) accounts for the effect of environmental temperature and humidity on thermal comfort, and is considered as a heat stress index most relevant to human health. In this study, we compare observation-based and modeled 1973-2012 summer WBGT over north hemispheric land between 10° N and 60° N covered by sufficient observations. We show that summer WBGT has trended upward since 1973, and that these upward trends are more likely to be anthropogenic than natural in origin. Of the observed 1.08 °C warming in summer WBGT during 1973-2012, greenhouse gas increases alone could have contributed 1.55 °C (90% confidence interval 1.04 2.25°C), which is partly offset by 0.51°C (0.01 1.20°C) cooling due to other anthropogenic forcings such as anthropogenic aerosols, ozone and land use change. At regional scales, the record summer mean WBGT experienced during 1973-2012 is now expected to be at least 70 times as likely to occur compared to if there were no anthropogenic influence. Future projections under the representative concentration pathway emissions scenario RCP8.5 that are constrained by observations indicate that within 20 years at least 50% of the future summers will have seasonal mean WBGT higher the highest in the historical record in all the analyzed regions, and that this percentage will increase dramatically to 95% by mid-century. The projected high WBGT temperatures can pose potentially dangerous impacts on human and natural systems, calling for urgent need for the development of adaptation measures.

  19. Water balance along a chain of tundra lakes: A 20-year isotopic perspective

    Science.gov (United States)

    Gibson, J. J.; Reid, R.

    2014-11-01

    Stable isotope measurements and isotope mass balance (IMB) calculations are presented in support of an unprecedented 20-year water balance assessment for a tailings pond and a chain of downstream lakes at the Salmita-Tundra mine site, situated near Courageous Lake, Northwest Territories, Canada (65°03‧N; 111°11‧W). The method is shown to provide a comprehensive annual and interannual perspective of water balance fluxes along a chain of lakes during the period 1991-2010, without the need for continuous streamflow gauging, and reveals important lake-order-dependent patterns of land-surface runoff, discharge accumulation, and several key diagnostic ratios, i.e., evaporation/inflow, evaporation/evapotranspiration, land-surface-runoff/precipitation and discharge/ precipitation. Lake evaporation is found to be a significant component of the water balance, accounting for between 26% and 32% of inflow to natural lakes and between 72% and 100% of inflow to mine-tailings ponds. Evaporation/evapotranspiration averages between 7% and 22% and is found to be higher in low-precipitation years, and in watersheds with a higher proportion of lakes. Runoff ratios for land-surface drainages and runoff ratios for watersheds (including lakes) ranged between 14-47% and 20-47%, respectively, and were higher in low precipitation years, in watersheds with a higher proportion of lakes, and in watersheds less affected by mining development. We propose that in general these two runoff ratios will likely converge as lake order increases and as land cover conditions become regionally representative. Notably, the study demonstrates application of IMB, validated with streamflow measurements, to constrain local water balance in a remote low-arctic region. For IMB chain-of-lakes applications, it underlines the importance of accounting for evaporatively-enriched upstream sources to avoid overestimation of evaporation losses.

  20. A levels and intelligence as predictors of medical careers in UK doctors: 20 year prospective study

    Science.gov (United States)

    McManus, I C; Smithers, Eleni; Partridge, Philippa; Keeling, A; Fleming, Peter R

    2003-01-01

    Objective To assess whether A level grades (achievement) and intelligence (ability) predict doctors' careers. Design Prospective cohort study with follow up after 20 years by postal questionnaire. Setting A UK medical school in London. Participants 511 doctors who had entered Westminster Medical School as clinical students between 1975 and 1982 were followed up in January 2002. Main outcome measures Time taken to reach different career grades in hospital or general practice, postgraduate qualifications obtained (membership/fellowships, diplomas, higher academic degrees), number of research publications, and measures of stress and burnout related to A level grades and intelligence (result of AH5 intelligence test) at entry to clinical school. General health questionnaire, Maslach burnout inventory, and questionnaire on satisfaction with career at follow up. Results 47 (9%) doctors were no longer on the Medical Register. They had lower A level grades than those who were still on the register (P < 0.001). A levels also predicted performance in undergraduate training, performance in postregistration house officer posts, and time to achieve membership qualifications (Cox regression, P < 0.001; b=0.376, SE=0.098, exp(b)=1.457). Intelligence did not independently predict dropping off the register, career outcome, or other measures. A levels did not predict diploma or higher academic qualifications, research publications, or stress or burnout. Diplomas, higher academic degrees, and research publications did, however, significantly correlate with personality measures. Conclusions Results of achievement tests, in this case A level grades, which are particularly used for selection of students in the United Kingdom, have long term predictive validity for undergraduate and postgraduate careers. In contrast, a test of ability or aptitude (AH5) was of little predictive validity for subsequent medical careers. PMID:12869457

  1. The next 20 years: how customer and workforce attitudes will evolve.

    Science.gov (United States)

    Howe, Neil; Strauss, William

    2007-01-01

    Business projects with very long time horizons--such as those involving product R&D, workplace design, and total compensation planning--have to contend with a crucial question: What will be the needs, demands, and desires of consumers and employees decades from now? If you think the answer is "Just more of the same," you're in for a surprise. Howe and Strauss, the authors of Generations, The Fourth Turning, Millennials Rising, and other books, have studied the differences among generations for some 30 years. Their extensive research has revealed a fascinating pattern--one so strong that it supports a measure of predictability. On the basis of historical precedent, they say, we can foresee how the generations that are alive today will think and act in decades to come. Three of those generations will still be vital forces in American society 20 years from now: Boomers, Generation X, and Millennials. Their attitudes and behaviors will have profound effects on the economy, the workplace, and social institutions in general. For example, as aging Boomers eschew high-tech medicine in favor of holistic self-care, natural foods, and mind-body healing techniques, some hospitals are opening new wings featuring alternative medicine and spiritual counseling. Gen Xers, having grown up in an era of failing schools and marriages, will remain alienated, disaffected, and pragmatic as they enter midlife. Already the greatest entrepreneurial generation in U.S. history, they will be highly effective at pushing innovation, efficiency, and mass customization. In contrast, young adult Millennials will favor teamwork, close family relationships, job security, and a bland popular culture. Their unprecedented digital empowerment and talent for organizing will create a political powerhouse and may even revitalize the union movement.

  2. Long-term bladder and bowel management after spinal cord injury: a 20-year longitudinal study.

    Science.gov (United States)

    Savic, Gordana; Frankel, Hans L; Jamous, Mohamed Ali; Soni, Bakulesh M; Charlifue, Susan

    2018-02-16

    Prospective observational. The aim of this study was to analyse changes in bladder and bowel management methods in persons with long-standing spinal cord injury (SCI). Two spinal centres in UK. Data were collected through interviews and examinations between 1990 and 2010 in a sample of persons injured more than 20 years prior to 1990. For the 85 participants who completed the 2010 follow-up, the mean age was 67.7 years and the mean duration of injury was 46.3 years, 80% were male, 37.7% had tetraplegia AIS grade A, B, or C, 44.7% paraplegia AIS A, B, or C, and 17.6% an AIS D grade regardless of level. In all, 50.6% reported having changed their bladder method, 63.1% their bowel method, and 40.5% both methods since they enroled in the study. The reasons for change were a combination of medical and practical. In men, condom drainage remained the most frequent bladder method, and in women, suprapubic catheter replaced straining/expressing as the most frequent method. The use of condom drainage and straining/expressing bladder methods decreased, whereas the use of suprapubic and intermittent catheters increased. Manual evacuation remained the most frequent bowel management method. The percentage of participants on spontaneous/voluntary bowel emptying, straining and medications alone decreased, whereas the use of colostomy and transanal irrigation increased over time. More than half the sample, all living with SCI for more than 40 years, required change in their bladder and bowel management methods, for either medical or practical reasons. Regular follow-ups ensure adequate change of method if/when needed.

  3. [Tobacco use by adolescents in Barcelona (Spain) and trends in the last 20 years].

    Science.gov (United States)

    Ariza, Carles; García-Continente, Xavier; Villalbí, Joan Ramon; Sánchez-Martínez, Francesca; Pérez, Anna; Nebot, Manel

    2014-01-01

    Smoking is a preventable cause of early death and the habit starts in adolescence. The aim of this study was to describe tobacco consumption in secondary school students in 2008 and trends in the last 20 years in Barcelona. We analyzed the trend in tobacco consumption by comparing data from 8 surveys carried out between 1987 and 2008 in the 8th (2nd year of Compulsory Secondary Education), 10th (4th year of Compulsory Secondary Education) and 12th (2nd year of Compulsory Secondary Education) years of secondary school. The FRESC questionnaire was used. Data on regular and daily consumption and associated factors in 2008 were gathered and compared with those corresponding to the previous studies. Percentages of annual change were calculated with Joinpoint regression and data were stratified by sex and year of education. In 2008, 6.1% of boys and 4.5% of girls in the 8th year, 15.8% and 20.4% of those in the 10th year, respectively, and 26.1% and 33.1% of those in the 12th year, respectively, were regular smokers. A strong association was noted between regular smoking and cannabis consumption in three school years, as well as with having friends who were smokers and poor school performance. At 15-16 years old, the average annual decrease from 1996 to 2008 was 6.8% in girls and 6.1% in boys. Adolescent smoking has been decreasing in the last few years in Barcelona. There is a strong association between tobacco use and cannabis consumption. Copyright © 2013 SESPAS. Published by Elsevier Espana. All rights reserved.

  4. A selective review of the first 20 years of instrumental variables models in health-services research and medicine.

    Science.gov (United States)

    Cawley, John

    2015-01-01

    The method of instrumental variables (IV) is useful for estimating causal effects. Intuitively, it exploits exogenous variation in the treatment, sometimes called natural experiments or instruments. This study reviews the literature in health-services research and medical research that applies the method of instrumental variables, documents trends in its use, and offers examples of various types of instruments. A literature search of the PubMed and EconLit research databases for English-language journal articles published after 1990 yielded a total of 522 original research articles. Citations counts for each article were derived from the Web of Science. A selective review was conducted, with articles prioritized based on number of citations, validity and power of the instrument, and type of instrument. The average annual number of papers in health services research and medical research that apply the method of instrumental variables rose from 1.2 in 1991-1995 to 41.8 in 2006-2010. Commonly-used instruments (natural experiments) in health and medicine are relative distance to a medical care provider offering the treatment and the medical care provider's historic tendency to administer the treatment. Less common but still noteworthy instruments include randomization of treatment for reasons other than research, randomized encouragement to undertake the treatment, day of week of admission as an instrument for waiting time for surgery, and genes as an instrument for whether the respondent has a heritable condition. The use of the method of IV has increased dramatically in the past 20 years, and a wide range of instruments have been used. Applications of the method of IV have in several cases upended conventional wisdom that was based on correlations and led to important insights about health and healthcare. Future research should pursue new applications of existing instruments and search for new instruments that are powerful and valid.

  5. The sensory-motor theory of rhythm and beat induction 20 years on: A new synthesis and future perspectives.

    Directory of Open Access Journals (Sweden)

    Neil Philip Todd

    2015-08-01

    Full Text Available Some 20 years ago Todd and colleagues proposed that rhythm perception is mediated by the conjunction of a sensory representation of the auditory input and a motor representation of the body (Todd 1994, 1995, and that a sense of motion from sound is mediated by the vestibular system (Todd 1992, 1993. These ideas were developed into a sensory-motor theory of rhythm and beat induction (Todd et al. 1999. A neurological substrate was proposed which might form the biological basis of the theory (Todd et al. 2002. The theory was implemented as a computational model and a number of experiments conducted to test it. In the following time there have been several key developments. One is the demonstration that the vestibular system is primal to rhythm perception, and in related work several experiments have provided further evidence that rhythm perception is body dependent. Another is independent advances in imaging, which have revealed the brain areas associated with both vestibular processing and rhythm perception. A third is the finding that vestibular receptors contribute to auditory evoked potentials (Todd et al. 2014ab. These behavioural and neurobiological developments demand a theoretical overview which could provide a new synthesis over the domain of rhythm perception. In this paper we suggest four propositions as the basis for such a synthesis. (1 Rhythm perception is a form of vestibular perception; (2 Rhythm perception evokes both external and internal guidance of somatotopic representations; (3 A link from the limbic system to the internal guidance pathway mediates the dance habit; (4 The vestibular reward mechanism is innate. The new synthesis provides an explanation for a number of phenomena not often considered by rhythm researchers. We discuss these along with possible computational implementations and alternative models and propose a number of new directions for future research.

  6. 20 years of long-term atrazine monitoring in a shallow aquifer in western Germany.

    Science.gov (United States)

    Vonberg, David; Vanderborght, Jan; Cremer, Nils; Pütz, Thomas; Herbst, Michael; Vereecken, Harry

    2014-03-01

    Atrazine was banned in Germany in 1991 due to findings of atrazine concentrations in ground- and drinking waters exceeding threshold values. Monitoring of atrazine concentrations in the groundwater since then provides information about the resilience of the groundwater quality to changing agricultural practices. In this study, we present results of a monitoring campaign of atrazine concentrations in the Zwischenscholle aquifer. This phreatic aquifer is exposed to intensive agricultural land use and susceptible to contaminants due to a shallow water table. In total 60 observation wells (OWs) have been monitored since 1991, of which 15 are sampled monthly today. Descriptive statistics of monitoring data were derived using the "regression on order statistics" (ROS) data censoring approach, estimating values for nondetects. The monitoring data shows that even 20 years after the ban of atrazine, the groundwater concentrations of sampled OWs remain on a level close to the threshold value of 0.1 μg l(-1) without any considerable decrease. The spatial distribution of atrazine concentrations is highly heterogeneous with OWs exhibiting permanently concentrations above the regulatory threshold on the one hand and OWs were concentrations are mostly below the limit of quantification (LOQ) on the other hand. A deethylatrazine-to-atrazine ratio (DAR) was used to distinguish between diffuse - and point-source contamination, with a global mean value of 0.84 indicating mainly diffuse contamination. Principle Component Analysis (PCA) of the monitoring dataset demonstrated relationships between the metabolite desisopropylatrazine, which was found to be exclusively associated with the parent compound simazine but not with atrazine, and between deethylatrazine, atrazine, nitrate, and the specific electrical conductivity. These parameters indicate agricultural impacts on groundwater quality. The findings presented in this study point at the difficulty to estimate mean concentrations

  7. Understanding the Internal Magnetic Field Configurations of ICMEs Using More than 20 Years of Wind Observations

    Science.gov (United States)

    Nieves-Chinchilla, T.; Vourlidas, A.; Raymond, J. C.; Linton, M. G.; Al-haddad, N.; Savani, N. P.; Szabo, A.; Hidalgo, M. A.

    2018-02-01

    The magnetic topology, structure, and geometry of the magnetic obstacles embedded within interplanetary coronal mass ejections (ICMEs) are not yet fully and consistently described by in situ models and reconstruction techniques. The main goal of this work is to better understand the status of the internal magnetic field of ICMEs and to explore in situ signatures to identify clues to develop a more accurate and reliable in situ analytical models. We take advantage of more than 20 years of Wind observations of transients at 1 AU to compile a comprehensive database of ICMEs through three solar cycles, from 1995 to 2015. The catalog is publicly available at wind.gsfc.nasa.gov and is fully described in this article. We identify and collect the properties of 337 ICMEs, of which 298 show organized magnetic field signatures. To allow for departures from idealized magnetic configurations, we introduce the term "magnetic obstacle" (MO) to signify the possibility of more complex configurations. To quantify the asymmetry of the magnetic field strength profile within these events, we introduce the distortion parameter (DiP) and calculate the expansion velocity within the magnetic obstacle. Circular-cylindrical geometry is assumed when the magnetic field strength displays a symmetric profile. We perform a statistical study of these two parameters and find that only 35% of the events show symmetric magnetic profiles and a low enough expansion velocity to be compatible with the assumption of an idealized cylindrical static flux rope, and that 41% of the events do not show the expected relationship between expansion and magnetic field compression in the front, with the maximum magnetic field closer to the first encounter of the spacecraft with the magnetic obstacle; 18% show contractions ( i.e. apparent negative expansion velocity), and 30% show magnetic field compression in the back. We derive an empirical relation between DiP and expansion velocity that is the first step toward

  8. Polycythemia vera: the natural history of 1213 patients followed for 20 years. Gruppo Italiano Studio Policitemia.

    Science.gov (United States)

    1995-11-01

    To reassess the natural history of polycythemia vera and to obtain reliable estimates of both incidence of thrombosis and survival for use in defining the sample size for therapeutic clinical trials. Retrospective cohort study of patients with polycythemia who had been followed for 20 years. 11 Italian hematology institutions. 1213 patients with polycythemia vera, which was diagnosed according to criteria established by the Polycythemia Vera Study Group and commonly used in clinical practice. All-cause mortality, venous and arterial thrombosis, and hematologic and nonhematologic neoplastic disease. Myocardial infarction and stroke were classified as major thrombotic events, and venous and peripheral arterial thrombosis were considered minor thrombotic events. The number of patients who died and the number of those who had major thrombotic events (combined end point) were used as a comprehensive measure of the benefit-risk ratio associated with the use of myelosuppressive agents. 634 fatal and nonfatal arterial and venous thromboses were recorded in 485 patients (41%); 36% of these episodes occurred during follow-up in 230 patients (19%), and 64% occurred either at presentation or before diagnosis. Thrombotic events occurred more frequently in the 2 years preceding diagnosis, suggesting a causal relation between the latent myeloproliferative disorder and the vascular event. The incidence of thrombosis during follow-up was 3.4%/y; older patients or those with a history of thrombosis had a higher risk for thrombosis. Overall mortality was 2.9/100 patients per year; thrombotic events and hematologic or nonhematologic cancers had similar effects on mortality. Patients receiving chemotherapy died three to four times more frequently than those not receiving chemotherapy. The increased risk for cancer in patients receiving myelosuppressive agents was seen approximately 6 years after diagnosis. In addition, the combined end point, computed as the sum of the hardest

  9. Continuum of hepatitis C care in France: A 20-year cohort study.

    Directory of Open Access Journals (Sweden)

    Coralie Hermetet

    Full Text Available Hepatitis C virus (HCV-infected patients require a specific continuum of care (CoC from HCV screening to treatment. We assessed CoC of HCV-infected patients in a longitudinal study.We established a cohort of subjects undergoing HCV screening (high alanine aminotransferase levels or risk factors during preventive consultations at a French regional medical center from 1993 to 2013. Patients were considered to be HCV-infected if HCV RNA was detected in their serum. CoC was assessed as described by Viner et al. (Hepatology 2015: Stage 1, HCV screening; Stage 2, HCV RNA testing; Stage 3, continuing care; Stage 4, antiviral treatment. Cox multivariate analysis was performed to identify factors favoring CoC, defined as at least one course of antiviral treatment.In total, 12,993 HCV tests were performed and 478 outpatients were found to be HCV-seropositive. We included 417 seropositive patients, after excluding false positives and patients lost to follow-up. The baseline characteristics of the patients were: sex ratio (M/F 1.4; mean age 38.5 years; intravenous drug use (IDU in 55%; and 28% in unstable social situations, estimated by the EPICES deprivation score. Antiviral treatment was initiated for 179 (42.9% of the 379 (90.9% patients attending specialist consultations. CoC was associated with screening after 1997 (HR 2.0, 95%CI 1.4-2.9, age > 45 years (HR 1.5, 95%CI 1.02-2.3, patient acceptance of care (HR 9.3, 95%CI 5.4-16.10, specialist motivation for treatment (HR 10.9, 95%CI 7.4-16.0, and absence of cancer (HR 6.7, 95%CI 1.6-27.9. Other comorbid conditions, such as depression and IDU, were not associated with CoC.Our 20-year cohort study reveals the real-life continuum of care for HCV-infected patients in France. The number of patients involved in HCV care after positive testing was substantial due to the organization of healthcare in France. An improved CoC along with new direct-acting antivirals should help to decrease chronic HCV infection.

  10. 20 years of experience with the NB/CU technology for superconducting cavities and perspectives for future developments

    CERN Document Server

    Calatroni, S

    2006-01-01

    The first niobium-coated copper cavities were produced at CERN in the early eighties. The sputter technology was chosen, first in the pure diode configuration and subsequently in the magnetron configuration, which was adopted for the successful series production of the LEP and LHC cavities. In parallel, an intensive R&D effort was undertaken at CERN and other Laboratories in order to understand the advantages and limitations of this technique. Some highlights of the present understanding will be given. Several new developments in the coating technique are being pursued around the world, which will be discussed together with their motivations.

  11. Percutaneous occlusion of vascular malformations in pediatric and adult patients: 20-year experience of a single center.

    Science.gov (United States)

    Pereira-da-Silva, Tiago; Martins, José Diogo; de Sousa, Lídia; Fiarresga, António; Trigo Pereira, Conceição; Cruz Ferreira, Rui; Ferreira Pinto, Fátima

    2016-02-01

    A case series on different vascular malformations (VM) treated with percutaneous occlusion in children and adults is presented. Percutaneous occlusion is usually the preferred treatment method for VM. Previous series have mostly focused on single types of devices and/or VM. Retrospective analysis of all patients who underwent percutaneous occlusion of VM in a single center, from 1995 to 2014, excluding patent ductus arteriosus. Clinical and angiographic data, procedural details, implanted devices, and complications were assessed. Procedural success was defined as effective device deployment with none or minimal residual flow. Predictors of procedural failure and complications were determined by multivariate analysis. A total of 123 VM were intervened in 47 patients with median age of 12 years (25 days-76 years). The VM included 55 pulmonary arteriovenous fistulae, 39 aortopulmonary collaterals, 10 systemic venovenous collaterals, 8 peripheral arteriovenous fistulae, 5 Blalock-Taussig shunts, 4 coronary fistulae, and 2 Fontan fenestrations. The 143 devices used included 80 vascular plugs, 38 coils, 22 duct occluders, and 3 foramen ovale or atrial septal defect occluders. Median vessel size was 4.5 (2.0-16.0) mm and device/vessel size ratio was 1.4 (1.1-2.0). Successful occlusion was achieved in 118 (95.9%) VM, including three reinterventions. Four (3.3%) clinically relevant complications occurred, without permanent sequelae. Lower body weight was independently associated with procedural failure and complications. To our knowledge, this is the largest series on different VM occluded percutaneously in children and adults, excluding patent ductus arteriosus. Percutaneous occlusion was effective and safe, using different devices. © 2015 Wiley Periodicals, Inc.

  12. 20-year experience with the Conrad modification of the Freer elevator as a pull-in suture introducer.

    Science.gov (United States)

    Torgerson, Cory; Conrad, Krzysztof

    2009-01-01

    A modified Freer elevator was created to aid the safe placement of alloplasts in a subcutaneous dissection pocket. We believe that this innovation represents a better way to insert nonrigid facial alloplasts and grafts and that it contributes to the reduced technique-related complications of migration, kinking, and asymmetry; it also minimizes tissue trauma and unnecessary surgical explorations.

  13. Radiotherapy with or without chemotherapy in the treatment of anal cancer. 20-year experience from a single institute

    Energy Technology Data Exchange (ETDEWEB)

    Fakhrian, K.; Sauer, T.; Klemm, S.; Bayer, C.; Haller, B.; Molls, M.; Geinitz, H. [Technische Univ. Muenchen (Germany). Klinikum rechts der Isar

    2013-01-15

    Purpose: To report the efficacy and toxicity of radio(chemo)therapy (RCT) in the management of squamous cell anal carcinoma (SQ-AC) and to evaluate the prognostic factors influencing the outcomes. Patients and methods: A consecutive cohort of 138 patients with cT1-4, cN0-3, cM0 SQ-AC were treated with RCT between 1988 and 2011 at our department. Median follow-up time for surviving patients from the start of RCT was 98 months (range, 1-236 months). Patients were treated with a median radiation dose of 56 Gy (range, 4-61 Gy). Concurrent chemotherapy was administered to 119 patients (86%). Results: The survival rates at 2, 5, and 10 years were 88 {+-} 3, 82 {+-} 4, and 59 {+-} 6%, respectively, with a median overall survival (OS) of 167 months. The cumulative incidence for local recurrence at 2 and 5 years was 8 {+-} 2 and 11 {+-} 3%, respectively. The median disease-free survival (DFS) and colostomy-free survival (CFS) times were 132 and 135 months, respectively. In 19 patients (14%), a distant metastasis was diagnosed after a median time of 19 months. In the multivariate analysis, UICC (International Union Against Cancer) stage I-II, female gender, Eastern Cooperative Oncology Group (ECOG) performance status of 0-1, and good/moderate histologic differentiation (G1-2) were significantly associated with a better OS, DFS, and CFS. Conformal radiotherapy planning techniques were significantly associated with a lower cumulative incidence of local recurrence (11 {+-} 3% vs. 38 {+-} 19% at 5 years, p = 0.006). A higher radiation dose beyond 54 Gy was not associated with an improvement in outcome, neither for smaller - (T1/T2) nor for larger tumors (T3/T4). Conclusion: RCT leads to excellent outcomes - especially in patients with stage I/II and G1/G2 tumors - with acceptable toxicity. The probable advantages of high-dose radiotherapy should be considered carefully against the risk of a higher rate of toxicity. Future studies are needed to investigate the role of a more intensified (systemic) treatment for patients with unfavorable prognostic factors such as T3/T4, N+, and/or poor cell differentiation. (orig.)

  14. Clinical-Epidemiological Pattern of Primary Immunodeficiencies in Malaysia 1987-2006: A 20 year experience in Four Malaysian Hospitals.

    Science.gov (United States)

    Noh, L M; Nasuruddin, B A; Abdul Latiff, A H; Noah, R M; Kamarul Azahar, M R; Norzila, M Z; Zulkifli, I; Gill, H K; Nik Zainal, N I; Suhaimi, A W M; Nik Khairulddin, N Y; Maraina, H; Intan, H I; Mat, I; Shahnaz, M; B H O, Azizi

    2013-01-01

    To determine the clinical and epidemiological characteristics of patients seen with primary immunodeficiencies referred at four Malaysian Hospitals between 1987 to 2007. Patient data were retrospectively obtained from patient records and supplemented by information from a standardized questionnaires taken at the time of diagnosis from 4 participating hospitals. The completed data were transferred to document records kept by the first author. The diagnoses made were based on criteria set by WHO Scientific Committee 1986. Fifty one (51) patients with completed records satisfied the criteria of primary immunodeficiencies based on WHO Scientific Committee 1986. Predominant Antibody deficiency (40.4%) is the commonest of the class of primary immunodeficiency (based on modified IUIS classification) followed by phagocytic defect (17.3%), combined immunodeficiencies (15.4%) and other cellular immunodeficiencies (11.5%). The commonest clinical presentation is pneumonia (54%) . A positive Family history with a close family relative afflicted was a strong pointer to diagnosis for PID (52.6%) Primary immnodeficiencies are seen in all the major ethnic groups of Malaysia, predominantly among Malays. As observed in other patient registries, diagnostic delay remains the major cause of morbidity and mortality. Primary immunodeficiencies is relative rare but is an emerging disease in Malaysia. Creating awareness of the disease, may reveal more cases within the community. It is sufficient to be a health issue in Malaysia as in other developing countries in the future.

  15. Enacting tobacco taxes by direct popular vote in the United States: lessons from 20 years of experience.

    Science.gov (United States)

    Lum, K L; Barnes, R L; Glantz, S A

    2009-10-01

    Tobacco tax increases reduce tobacco use, can provide funds for tobacco prevention and enjoy broad public support. Because of tobacco industry influence in legislatures, US public health advocates have shifted the venue for tobacco tax policymaking to direct popular vote 22 times since 1988. We combined case studies of individual state campaigns with tobacco industry documents to identify strategies related to outcome. The tobacco industry developed a voter segmentation model to determine which tobacco tax increases it could defeat. Two industry arguments arising from this model often were raised in losing campaigns-the tax increase did not dedicate enough to tobacco control and hospitals and health maintenance organisations would profit. The industry effectively influenced early voters. Success was associated with building a strong base of public support before the campaign, dedicating sufficient funds to tobacco control, avoiding proposals largely devoted to financing hospitals and other medical service providers, effectively engaging grassroots and framing the campaign with clear justifications for cigarette tax increases. Tobacco tax ballot measures commonly allocated substantial funds to medical services; tobacco companies are becoming more successful in making this use of funds an issue. Proponents' campaigns should be timed to account for the trend to voting well before election day. Ballot measures to increase tobacco taxes with a substantial fraction of the money devoted to tobacco control activities will probably fare better than ones that give priority to funding medical services.

  16. Improving health outcomes through concurrent HIV program scale-up and health system development in Rwanda: 20 years of experience.

    Science.gov (United States)

    Nsanzimana, Sabin; Prabhu, Krishna; McDermott, Haley; Karita, Etienne; Forrest, Jamie I; Drobac, Peter; Farmer, Paul; Mills, Edward J; Binagwaho, Agnes

    2015-09-09

    The 1994 genocide against the Tutsi destroyed the health system in Rwanda. It is impressive that a small country like Rwanda has advanced its health system to the point of now offering near universal health insurance coverage. Through a series of strategic structural changes to its health system, catalyzed through international assistance, Rwanda has demonstrated a commitment towards improving patient and population health indicators. In particular, the rapid scale up of antiretroviral therapy (ART) has become a great success story for Rwanda. The country achieved universal coverage of ART at a CD4 cell count of 200 cells/mm(3) in 2007 and increased the threshold for initiation of ART to ≤350 cells/mm(3) in 2008. Further, 2013 guidelines raised the threshold for initiation to ≤500 cells/mm(3) and suggest immediate therapy for key affected populations. In 2015, guidelines recommend offering immediate treatment to all patients. By reviewing the history of HIV and the scale-up of treatment delivery in Rwanda since the genocide, this paper highlights some of the key innovations of the Government of Rwanda and demonstrates the ways in which the national response to the HIV epidemic has catalyzed the implementation of interventions that have helped strengthen the overall health system.

  17. Tumor de Pancoast: nuestra experiencia en 20 años Pancoast tumor: our experience of 20 years

    Directory of Open Access Journals (Sweden)

    Bárbaro Agustín Armas Pérez

    2007-03-01

    Full Text Available Se realizó un estudio descriptivo transversal de 11 pacientes operados por tumor de Pancoast, en el transcurso de dos decenios. Se hizo una revisión bibliográfica amplia del tema haciendo énfasis en el diagnóstico, estadificación y tratamiento. El mayor porcentaje de pacientes era del sexo masculino, fumadores y portadores de masas radiopacas tenues en el vértice, las cuales se acompañaban de dolor en pared costal irradiado a hombro, brazo y cuello. No siempre la resección quirúrgica fue completa y radical y los pacientes que presentaron mejores índices de supervivencia fueron los tratados mediante cirugía excerética amplia y terapia neoadyuvante. La vía de abordaje más utilizada fue la posterolateral y en un sólo caso la anterior-transcervical, que mucho nos satisfizo. La supervivencia fue corta aunque la serie es pequeña y no hubo mortalidad antes de los 30 días tras la operación

  18. Changes in phenology and the influence on the carbon sequestration in a Danish beech forest over 20 years

    DEFF Research Database (Denmark)

    Pilegaard, Kim; Ibrom, Andreas

    Observations of carbon sequestration in a Danish beech forest over the last 20 years have shown a steady increase in NEE. Earlier studies (Pile- gaard et al. 2011) have shown, that about half of the increase can be attributed to an increase in the growing season length. The growing sea- son has...... 6 years using the R package Phenopix (Filippa et al. 2016). The new data is compared with CUP and LP to give more detailed information on the phenology. The information is used to examine the evolution of net ecosystem exchange (NEE) over the 20 year period....

  19. What has happened in about the last 20 years in the Canyoles watershed?

    Science.gov (United States)

    Ángel González Peñaloza, Félix; Cerdà, Artemi; Díaz del Olmo, Fernando

    2013-04-01

    Along history, the Mediterranean arid lands have undergone widespread land use transformation, especially in recent decades (Piqueras, 2012). There are changes driven by socio-economic conditions, such as European Agricultural Policies (MacDonald et al., 2000; Keenleyside and Tucker, 2010; Renwick et al., 2013), which have caused land degradation processes (soil erosion, soil sealing, water pollution, salinization, wildfires, land abandonment, urban sprawl and intensive agricultural practices). Land degradation is the results of a complex Socio Ecological System (SES) which should be addressed using the Geographical Information System (GIS) to identify and assess the spatial variation of land use change. Therefore, the aim of this work has been to describe and assess the land use change by human activities in a typical Mediterranean watershed (Cànyoles Valley) located at South-East of Iberian Peninsula as a part of the Land Ecosystem and Degradation Desertification Response Assessment (LEDDRA) project, which has undergone a quick land use change in last two decades (1986 - 2005). Results reveal that the surface area devoted to rainfed crops (e.g., olive crops (47 %) and vineyards (28 %) and forestry have decline significantly; while the citrus orchards (irrigated crops) and unproductive areas (e.g., roads and railways, urban areas) have been increasing its surface in just about last 20 years in 45 % and 67 %, respectively. According to the literature review (Cerdà, 1994; Cerdá et al., 1999, 2007; Cerdà, 2007; Bodí et al., 2012; González-Peñaloza, 2012) these recent changes, in the study site, have caused many environmental disturbances mainly due to the lack control strategies plans of land degradation. Acknowledgements This research is being conducted by the EU project "Land Ecosystem and Degradation Desertification: Assessing the Fit of Responses" LEDDRA 243857 CONSORTIUM AGREEMENT. TR07 - VII PROGRAMA MARCO - ENERGÍA FP7-ENERGY-2007-2-TREN. - European

  20. Latest Insights on Adenovirus Structure and Assembly

    Directory of Open Access Journals (Sweden)

    Carmen San Martín

    2012-05-01

    Full Text Available Adenovirus (AdV capsid organization is considerably complex, not only because of its large size (~950 Å and triangulation number (pseudo T = 25, but also because it contains four types of minor proteins in specialized locations modulating the quasi-equivalent icosahedral interactions. Up until 2009, only its major components (hexon, penton, and fiber had separately been described in atomic detail. Their relationships within the virion, and the location of minor coat proteins, were inferred from combining the known crystal structures with increasingly more detailed cryo-electron microscopy (cryoEM maps. There was no structural information on assembly intermediates. Later on that year, two reports described the structural differences between the mature and immature adenoviral particle, starting to shed light on the different stages of viral assembly, and giving further insights into the roles of core and minor coat proteins during morphogenesis [1,2]. Finally, in 2010, two papers describing the atomic resolution structure of the complete virion appeared [3,4]. These reports represent a veritable tour de force for two structural biology techniques: X-ray crystallography and cryoEM, as this is the largest macromolecular complex solved at high resolution by either of them. In particular, the cryoEM analysis provided an unprecedented clear picture of the complex protein networks shaping the icosahedral shell. Here I review these latest developments in the field of AdV structural studies.

  1. Latest ATLAS measurements on top quark properties

    CERN Document Server

    Derue, Frederic; The ATLAS collaboration

    2017-01-01

    The top quark is unique among the known quarks in that it decays before it has an opportunity to form hadronic bound states. This makes measurements of its properties particularly interesting as one can access directly the properties of a bare quark. The latest measurements of these properties with the ATLAS detector at the LHC are presented using 8 TeV and 13 TeV data, excluding results from single top production. Measurements of top quark spin observables in top-antitop events, each sensitive to a different coefficient of the spin density matrix, are presented and compared to the Standard Model predictions. The helicity of the W boson from the top decays and the production angles of the top quark are further discussed. New results on the measurment of color flow effects in $t{\\bar t}$ events are presented. Limits on the rate of flavour changing neutral currents in the production or decay of the top quark are reported. The cross-section measurement of photons produced in association with top-quark pairs is a...

  2. Latest results from CERES/NA45

    CERN Document Server

    AUTHOR|(CDS)2074200; Adamova, D; Agakichiev, G; Appelshuser, H; Belaga, V; Braun-Munzinger, P; Campagnolo, R; Castillo, A; Cherlin, A; Damjanovic, S; Dietel, T; Dietrich, L; Drees, A; Esumi, S I; Filimonov, K; Fomenko, K; Fraenkel, Zeev; Garabatos, C; Glässel, P; Hering, G; Holeczek, J; Kushpil, V; Lenkeit, B C; Ludolphs, W; Maas, A; Marin, A; Messer, F; Milosevic, J; Milov, A; Mikowiec, D; Musa, L; Panebratsev, Yu A; Petchenova, O Yu; Petracek, V; Pfeiffer, A; Rak, J; Ravinovich, I; Rehak, P; Richter, M; Sako, H; Schmitz, W; Schükraft, J; Sedykh, S; Seipp, W; Sharma, A; Shimansky, S S; Slivova, J; Specht, H J; Stachel, J; Sumbera, M; Tilsner, H; Tserruya, Itzhak; Wienold, T; Windelband, B; Wurm, J P; Xie, W; Yurevich, S; Yurevich, V; Wessels, Johannes P.

    2003-01-01

    In this talk latest results from the analysis of $e^{+}e^{-}$ pairs emitted in Pb + Au collisions at 40 AGeV/c and a combined analysis of all data available at 158 AGeV/c are presented. The enhancement of low-mass $e^{+}e^{-}$ pairs $(m_{ee}>0.2 GeV/c^{2})$ with respect to the expected yield from hadron decays first reported at 158 AGeV/c is also found at 40 AGeV/c and is even larger there. Comparing to various theoretical models based on $\\pi^{+}\\pi^{-}$ annihilation, the data can only be reproduced, if the properties of the intermediate $\\rho$ in the hot and dense medium are modified. Theoretically, the modification is linked to baryon density rather than temperature. Constraints from hadron data taken at the same beam energies indeed indicate a fireball evolution along a trajectory of higher baryon density at 40 AGeV/c, consistent with the observed larger enhancement factor.

  3. 20 years after Chernobyl Accident. Future outlook. National Report of Ukraine

    Energy Technology Data Exchange (ETDEWEB)

    Baloga, V I [ed.

    2006-07-01

    The scale of the Chernobyl catastrophe - the most severe man made nuclear accident in the history of mankind - is well known to both scientists and politicians worldwide. The basic causes of the catastrophe were as follows: Conduction an incompletely and incorrectly prepared electrical experiment; The low professional level of operators, and of the NPP management and the officials of the Ministry of Electrification as a whole in the area of NPP safety; Insufficient safety level of the graphite-uranium reactor RBMK-1000; Constructive faults RBMK-1000; Personnel mistakes. The report describes and reviews the actions of the governments of the USSR, Ukraine, and the Verkhovna Rada of Ukraine; the activities of scientists in elimination of the accident consequences; and elimination of the additional experience gained over the past years. Mistakes made during these activities are highlighted.

  4. ESTSS at 20 years: "a phoenix gently rising from a lava flow of European trauma".

    Science.gov (United States)

    Orner, Roderick J

    2013-01-01

    Roderick J. Ørner, who was President between 1997 and 1999, traces the phoenix-like origins of the European Society for Traumatic Stress Studies (ESTSS) from an informal business meeting called during the 1st European Conference on Traumatic Stress (ECOTS) in 1987 to its emergence into a formally constituted society. He dwells on the challenges of tendering a trauma society within a continent where trauma has been and remains endemic. ESTSS successes are noted along with a number of personal reflections on activities that give rise to concern for the present as well as its future prospects. Denial of survivors' experiences and turning away from survivors' narratives by reframing their experiences to accommodate helpers' theory-driven imperatives are viewed with alarm. Arguments are presented for making human rights, memory, and ethics core elements of a distinctive European psycho traumatology, which will secure current ESTSS viability and future integrity.

  5. 20 years after Chernobyl Accident. Future outlook. National Report of Ukraine

    International Nuclear Information System (INIS)

    Baloga, V.I.

    2006-01-01

    The scale of the Chernobyl catastrophe - the most severe man made nuclear accident in the history of mankind - is well known to both scientists and politicians worldwide. The basic causes of the catastrophe were as follows: Conduction an incompletely and incorrectly prepared electrical experiment; The low professional level of operators, and of the NPP management and the officials of the Ministry of Electrification as a whole in the area of NPP safety; Insufficient safety level of the graphite-uranium reactor RBMK-1000; Constructive faults RBMK-1000; Personnel mistakes. The report describes and reviews the actions of the governments of the USSR, Ukraine, and the Verkhovna Rada of Ukraine; the activities of scientists in elimination of the accident consequences; and elimination of the additional experience gained over the past years. Mistakes made during these activities are highlighted

  6. Population Trends in Percutaneous Coronary Intervention 20-Year Results From the SCAAR (Swedish Coronary Angiography and Angioplasty Registry)

    NARCIS (Netherlands)

    Fokkema, Marieke L.; James, Stefan K.; Albertsson, Per; Akerblom, Axel; Calais, Fredrik; Eriksson, Peter; Jensen, Jens; Nilsson, Tage; de Smet, Bart J.; Sjogren, Iwar; Thorvinger, Bjorn; Lagerqvist, Bo

    2013-01-01

    Objectives The aim of this study was to describe the characteristics and outcome of all consecutive patients treated with percutaneous coronary intervention (PCI) in an unselected nationwide cohort over the past 2 decades. Background Over the last 20 years, treatment with PCI has evolved

  7. The Late-Divorce Phenomenon: The Causes and Impact of Ending 20-Year-Old or Longer Marriages

    Science.gov (United States)

    Deckert, Pamela; Langelier, Regis

    1978-01-01

    This study examined late divorce occurring after 20 years or more of marriage. Divorce was rated the highest in stress for any major life event. Even though divorce resulted in much social readjustment and stress, it also resulted in positive feelings, personal independence, and relief. Subjects were 427 Quebec residents. (Author)

  8. Culturally Relevant Pedagogy 20 Years Later: Progress or Pontificating? What Have We Learned, and Where Do We Go?

    Science.gov (United States)

    Howard, Tyrone C.; Rodriguez-Scheel, Andrea

    2017-01-01

    In this paper, the authors discuss the concept of culturally relevant pedagogy 20 years after its introduction to the professional literature. The authors discuss key tenets of culturally relevant pedagogy, examine empirical examples of it, and makes recommendations on how the concept may inform and influence the outcomes of culturally diverse…

  9. Fibrosis progression in interferon treatment-naive Chinese plasma donors with chronic hepatitis C for 20 years: a cohort study

    Directory of Open Access Journals (Sweden)

    Jun-Feng Li

    2014-10-01

    Conclusions: Based on histopathology results, the progression of fibrosis in patients with CHC infected by repeated plasma donation is slow after HCV infection of approximately 20 years. Liver inflammation is closely related to the development of moderate to severe liver fibrosis.

  10. Long-term survival rate of implant-supported overdentures with various attachment systems: A 20-year retrospective study

    Directory of Open Access Journals (Sweden)

    Hao-Sheng Chang

    2015-03-01

    Conclusion: The overall survival rate of dental implants with overdenture rehabilitation was 95.3% (91.3% in maxillae vs. 96.4% in mandibles within the past 20 years. With careful treatment planning, implant-supported overdenture is an interesting treatment alternative with better esthetic, retention, stability, and good hygienic maintenance for patients with severe ridge resorption.

  11. Dietary pattern and 20 year mortality in elderly men in Finland, Italy and the Netherlands: Longitudinal cohort study.

    NARCIS (Netherlands)

    Huijbregts, P.; Feskens, E.J.M.; Résénen, L.; Fidanza, F.; Nissinen, A.; Menotti, A.; Kromhout, D.

    1997-01-01

    OBJECTIVE: To investigate the association of dietary pattern and mortality in international data. DESIGN: Cohort study with 20 years' follow up of mortality. SETTING: Five cohorts in Finland, the Netherlands, and Italy. SUBJECTS: Population based random sample of 3045 men aged 50-70 years in 1970.

  12. Latest advances in high brightness disk lasers

    Science.gov (United States)

    Kuhn, Vincent; Gottwald, Tina; Stolzenburg, Christian; Schad, Sven-Silvius; Killi, Alexander; Ryba, Tracey

    2015-02-01

    In the last decade diode pumped solid state lasers have become an important tool for many industrial materials processing applications. They combine ease of operation with efficiency, robustness and low cost. This paper will give insight in latest progress in disk laser technology ranging from kW-class CW-Lasers over frequency converted lasers to ultra-short pulsed lasers. The disk laser enables high beam quality at high average power and at high peak power at the same time. The power from a single disk was scaled from 1 kW around the year 2000 up to more than 10 kW nowadays. Recently was demonstrated more than 4 kW of average power from a single disk close to fundamental mode beam quality (M²=1.38). Coupling of multiple disks in a common resonator results in even higher power. As an example we show 20 kW extracted from two disks of a common resonator. The disk also reduces optical nonlinearities making it ideally suited for short and ultrashort pulsed lasers. In a joint project between TRUMPF and IFSW Stuttgart more than 1.3 kW of average power at ps pulse duration and exceptionally good beam quality was recently demonstrated. The extremely low saturated gain makes the disk laser ideal for internal frequency conversion. We show >1 kW average power and >6 kW peak power in multi ms pulsed regime from an internally frequency doubled disk laser emitting at 515 nm (green). Also external frequency conversion can be done efficiently with ns pulses. >500 W of average UV power was demonstrated.

  13. The DTU13 MSS (Mean Sea Surface) and MDT (Mean Dynamic Topography) from 20 Years of Satellite Altimetry

    DEFF Research Database (Denmark)

    Andersen, Ole Baltazar; Knudsen, Per; Stenseng, Lars

    2015-01-01

    The DTU13MSS is the latest release of the global high resolution mean sea surface (MSS) from DTU Space. The new MSS is based on multi-mission satellite altimetry from 10 different satellites. Three major advances have been made in order to release the new MSS. The time series have been extended t...

  14. The Catalonia World Health Organization demonstration project for palliative care implementation: quantitative and qualitative results at 20 years.

    Science.gov (United States)

    Gómez-Batiste, Xavier; Caja, Carmen; Espinosa, Jose; Bullich, Ingrid; Martínez-Muñoz, Marisa; Porta-Sales, Josep; Trelis, Jordi; Esperalba, Joaquim; Stjernsward, Jan

    2012-04-01

    Catalonia (Spain) has a total population of 7.3 million citizens for whom the National Health Service (NHS) provides health care that is free at the point of access. The prevalence of terminally ill patients is between 30,100 and 39,600. Twenty years ago, the World Health Organization (WHO), in collaboration with the Catalan Department of Health and the Catalan Institute of Oncology, began a demonstration project (WHO Demonstration Project) in palliative care (PC) with the aim of implementing specialist PC services, generating experience in this field, identifying areas for improvement, and introducing educative procedures (clinical and nonclinical). Over the past 20 years, 237 PC clinical services (72 home care support teams, 49 hospital support teams, 60 units with 742 dedicated beds, 50 outpatient clinics, and six psychosocial support teams) have been implemented. In the five years since the previous evaluation, 57 new clinical services (15 new hospital support teams, 36 outpatient clinics, and six psychosocial support teams among others) and four nonclinical services (education, research, WHO Collaborating Center, and planning) have been implemented. During the year 2010, a total of 46,200 processes were undertaken for the care of 23,100 patients, of whom 12,100 (52%) had cancer and 11,000 (48%) had other chronic advanced diseases. The overall yearly costs are around €52,568,000, with an overall savings of €69,300,000 (€2275 per patient, net savings to the NHS of €16,732,000). In the last five years, three qualitative evaluations and a benchmarking process have been performed to identify weak points and inequities in care provision among districts. Systematic assessments indicate high cost-effectiveness of care as well as high levels of satisfaction by patients and their relatives, thus reinforcing the principle that access to PC under the auspices of the NHS at the end of life is a basic human right. Copyright © 2012 U.S. Cancer Pain Relief Committee

  15. Impact of extreme prematurity on family functioning and maternal health 20 years later.

    Science.gov (United States)

    Saigal, Saroj; Pinelli, Janet; Streiner, David L; Boyle, Michael; Stoskopf, Barbara

    2010-07-01

    The goal was to examine the impact of illness on families and the long-term effects on the health of parents of young adults (YAs) who were born with extremely low birth weight (ELBW), compared with normal birth weight (NBW) control subjects. A longitudinal cohort study was performed. Participants were mothers of eligible ELBW and NBW YAs. Information was obtained with well-validated questionnaires. At young adulthood, 130 (81%) of 161 ELBW group and 126 (89%) of 141 NBW group mothers participated. There were no significant differences in scores between groups with respect to marital disharmony, family dysfunction, maternal mood, state anxiety, social support, depression, and maternal physical and mental health. The finding of no differences was unchanged when 27 YAs with neurosensory impairment (NSI) were excluded, except for family dysfunction scores, which were paradoxically lower for families with YAs with NSI. Although the impact scores revealed that significantly more parents of ELBW YAs were negatively affected with respect to their jobs and educational or training opportunities, mothers of ELBW YAs reported that the experience of caring for their child brought their family closer together and that relatives and friends were more helpful and understanding, compared with mothers of NBW YAs. Significantly more mothers of ELBW YAs with NSI, compared with those without NSI, felt better about themselves for having managed their child's health. It seems that, by young adulthood, there is a minimally negative long-term impact of having an ELBW child in the family, regardless of the presence of NSI.

  16. Physics and Astronomy New Faculty Workshops: 20 Years of Workshops and 2000 Faculty

    Science.gov (United States)

    Hilborn, Robert

    Most college and university new faculty members start their teaching careers with almost no formal training in pedagogy. To address this issue, the American Association of Physics Teachers, the American Astronomical Society, and the American Physical Society have been offering since 1996 workshops for physics and astronomy new faculty members (and in recent years for experienced faculty members as well). The workshops introduce faculty members to a variety of interactive engagement teaching (IET) methods and the evidence for their effectiveness, embedded in a framework of general professional development. Currently the workshops engage about 50% of the new tenure-track hires in physics and astronomy. The workshops are quite successful in making the participants aware of IET methods and motivating them to implement them in their classes. However, about 1/3 of the participants stop using IET methods within a year or two. The faculty members cite (a) lack of time and energy to change, (b) content coverage concerns, and (c) difficulty getting students engaged as reasons for their discontinuance. To help overcome these barriers, we have introduced faculty online learning communities (FOLCs). The FOLCs provide peer support and advice through webinars and coaching from more experienced faculty members. Recommendations based on the workshops and the experiences of the participants can enhance the teaching effectiveness of future physics and astronomy faculty members. This work was supported in part by NSF Grant 1431638.

  17. Comorbidity of Anxiety and Depression in Children and Adolescents: 20 Years After

    Science.gov (United States)

    Cummings, Colleen M.; Caporino, Nicole E.; Kendall, Philip C.

    2014-01-01

    Brady and Kendall (1992) concluded that although anxiety and depression in youth are meaningfully linked, there are important distinctions, and additional research was needed. Since then, studies of anxiety-depression comorbidity in youth have increased exponentially. Following a discussion of comorbidity, we review existing conceptual models and propose a multiple pathways model to anxiety-depression comorbidity. Pathway 1 describes youth with a diathesis for anxiety, with subsequent comorbid depression resulting from anxiety-related impairment. Pathway 2 refers to youth with a shared diathesis for anxiety and depression, who may experience both disorders simultaneously. Pathway 3 describes youth with a diathesis for depression, with subsequent comorbid anxiety resulting from depression-related impairment. Additionally, shared and stratified risk factors contribute to the development of the comorbid disorder, either by interacting with disorder-related impairment or by predicting the simultaneous development of the disorders. Our review addresses descriptive and developmental factors, gender differences, suicidality, assessments, and treatment-outcome research as they relate to comorbid anxiety and depression, and to our proposed pathways. Research since 1992 indicates that comorbidity varies depending on the specific anxiety disorder, with Pathway 1 describing youth with either social phobia or separation anxiety disorder and subsequent depression, Pathway 2 applying to youth with co-primary generalized anxiety disorder and depression, and Pathway 3 including depressed youth with subsequent social phobia. The need to test the proposed multiple pathways model and to examine (a) developmental change and (b) specific anxiety disorders is highlighted. PMID:24219155

  18. Latest status of manufacturing activity of ITER divertor and engineering issues on tungsten divertor

    International Nuclear Information System (INIS)

    Suzuki, Satoshi

    2011-01-01

    Divertors for ITER are now in construction. In the present chapter, the specification and the latest status of manufacturing of ITER divertors are presented. In addition, issues in the development of divertors for the fusion demo reactor are given on the basis of experiences on the ITER divertor development. (J.P.N.)

  19. Socioeconomic factors and mortality in emergency general surgery: trends over a 20-year period.

    Science.gov (United States)

    Armenia, Sarah J; Pentakota, Sri Ram; Merchant, Aziz M

    2017-05-15

    Socioeconomic factors such as race, insurance, and income quartiles have been identified as independent risk factors in emergency general surgery (EGS), but this impact has not been studied over time. We sought to identify trends in disparities in EGS-related operative mortality over a 20-y period. The National Inpatient Sample was used to identify patient encounters coded for EGS in 1993, 2003, and 2013. Logistic regression models were used to examine the adjusted relationship between race, primary payer status, and median income quartiles and in-hospital mortality after adjusting for patients' age, gender, Elixhauser comorbidity score, and hospital region, size, and location-cum-teaching status. We identified 391,040 patient encounters. In 1993, Black race was associated with higher odds of in-hospital mortality (odds ratio [95% confidence interval]: 1.35 [1.20-1.53]) than White race, although this difference dissipated in subsequent years. Medicare, Medicaid, and underinsured patients had a higher odds of mortality than those with private insurance for the entire 20-y period; only the disparity in the underinsured decreased over time (1993, 1.63 [1.35-1.98]; 2013, 1.41 [1.20-1.67]). In 2003 (1.23 [1.10-1.38]) and 2013 (1.23 [1.11-1.37]), patients from the lowest income quartile were more likely to die after EGS than patients from the highest income quartile. Socioeconomic disparities in EGS-related operative morality followed inconsistent trends. Over time, while gaps in in-hospital mortality among Blacks and Whites have narrowed, disparities among patients belonging to lowest income quartile have worsened. Medicare and Medicaid beneficiaries continued to experience higher odds of in-hospital mortality relative to those with private insurance. Copyright © 2017 Elsevier Inc. All rights reserved.

  20. 20 years of cosmic muons research performed in IFIN-HH

    International Nuclear Information System (INIS)

    Mitrica, Bogdan

    2012-01-01

    During the last two decades a modern direction in particle physics research has been developed in IFIN-HH Bucharest, Romania. The history started with the WILLI detector built in IFIN-HH Bucharest in collaboration with KIT Karlsruhe (formerly Forschungszentrum Karlsruhe). The detector was designed for measurements of the low energy muon charge ratio ( 0.4GeV, show a diurnal modulation of the muon flux. The analysis of the muon events for energies 15 eV. Simulation studies and preliminary experimental tests, regarding the performances of the mini-array, have been performed using H and Fe primaries, with energies in a range 10 13 eV - 10 15 eV. The results show detailed effects of the direction of EAS incidence relative to the geomagnetic field, depending, in particular, of the primary mass. Based on the results, we can say that WILLI-EAS experiment could be used for testing the hadronic interaction models. Measurements of the high energy muon flux in underground of the salt mine from Slanic Prahova, Romania was performed using a new mobile detector developed in IFIN-HH, Bucharest. Consisting of 2 scintillator plates measuring in coincidence, the detector is installed on a van which facilitates measurements on different positions at surface or in underground. The detector was used to measure muon fluxes in different locations at surface or in underground. The detector was used to measure muon fluxes at different sites of Romania and in the underground of the salt mines from Slanic Prahova, Romania where IFIN-HH has a modern underground laboratory. New methods for the detection of cosmic ray muons are investigated in our institute based on scintillator techniques using optical fiber and MPPC photodyodes.

  1. OPPIDUM surveillance program: 20 years of information on drug abuse in France.

    Science.gov (United States)

    Frauger, Elisabeth; Moracchini, Christophe; Le Boisselier, Reynald; Braunstein, David; Thirion, Xavier; Micallef, Joëlle

    2013-12-01

    It is important to assess drug abuse liability in 'real life' using different surveillance systems. Some are based on specific population surveys, such as individuals with drug abuse or dependence, or under opiate maintenance treatment, because this population is very familiar with drugs and is more likely to divert or abuse them. In France, an original surveillance system based on this specific population and called 'Observation of illegal drugs and misuse of psychotropic medications (OPPIDUM) survey' was set up in 1990 as the first of its kind. The aim of this article is to describe this precursor of French drug abuse surveillance using different examples, to demonstrate its ability to effectively give health authorities and physicians interesting data on drug abuse. OPPIDUM is an annual, cross-sectional survey that anonymously collects information on abuse and dependence observed in patients recruited in specialized care centers dedicated to drug dependence. From 1990 to 2010, a total of 50,734 patients were included with descriptions of 102,631 psychoactive substance consumptions. These data have outlined emergent behaviors such as the misuse of buprenorphine by intravenous or nasal administration. It has contributed to assess abuse liability of emergent drugs such as clonazepam or methylphenidate. This surveillance system was also able to detect the decrease of flunitrazepam abuse following implementation of regulatory measures. OPPIDUM's twenty years of experience clearly demonstrate that collection of valid and useful data on drug abuse is possible and can provide helpful information for physicians and health authorities. © 2013 The Authors Fundamental and Clinical Pharmacology © 2013 Société Française de Pharmacologie et de Thérapeutique.

  2. Portrayal of caesarean section in Brazilian women’s magazines: 20 year review

    Science.gov (United States)

    Daher, Silvia; Betrán, Ana Pilar; Widmer, Mariana; Montilla, Pilar; Souza, Joao Paulo; Merialdi, Mario

    2011-01-01

    Objective To assess the quality and comprehensiveness of the information on caesarean section provided in Brazilian women’s magazines. Design Review of articles published during 1988-2008 in top selling women’s magazines. Setting Brazil, one of the countries with the highest caesarean section rates in the world. Data sources Women’s magazines with the largest distribution during the study period, identified through the official national media indexing organisations. Selection criteria Articles with objective scientific information or advice, comments, opinions, or the experience of ordinary women or celebrities on delivery by caesarean section. Main outcome measures Sources of information mentioned by the author of the article, the accuracy and completeness of data presented on caesarean section, and alleged reasons why women would prefer to deliver though caesarean section. Results 118 articles were included. The main cited sources of information were health professionals (78% (n=92) of the articles). 71% (n=84) of the articles reported at least one benefit of caesarean section, and 82% (n=97) reported at least one short term maternal risk of caesarean section. The benefits most often attributed to delivery by caesarean section were reduction of pain and convenience for family or health professionals. The most frequently reported short term maternal risks of caesarean section were increased time to recover and that it is a less natural way of giving birth. Only one third of the articles mentioned any long term maternal risks or perinatal complications associated with caesarean section. Fear of pain was the main reported reason why women would prefer to deliver by caesarean section. Conclusions Most of the articles published in Brazilian women’s magazines do not use optimal sources of information. The portrayal of caesarean section is mostly balanced, not explicitly in favour of one or another route of delivery, but incomplete and may be leading women to

  3. Portrayal of caesarean section in Brazilian women's magazines: 20 year review.

    Science.gov (United States)

    Torloni, Maria Regina; Daher, Silvia; Betrán, Ana Pilar; Widmer, Mariana; Montilla, Pilar; Souza, Joao Paulo; Merialdi, Mario

    2011-01-25

    To assess the quality and comprehensiveness of the information on caesarean section provided in Brazilian women's magazines. Review of articles published during 1988-2008 in top selling women's magazines. Brazil, one of the countries with the highest caesarean section rates in the world. Women's magazines with the largest distribution during the study period, identified through the official national media indexing organisations. Articles with objective scientific information or advice, comments, opinions, or the experience of ordinary women or celebrities on delivery by caesarean section. Sources of information mentioned by the author of the article, the accuracy and completeness of data presented on caesarean section, and alleged reasons why women would prefer to deliver though caesarean section. 118 articles were included. The main cited sources of information were health professionals (78% (n=92) of the articles). 71% (n=84) of the articles reported at least one benefit of caesarean section, and 82% (n=97) reported at least one short term maternal risk of caesarean section. The benefits most often attributed to delivery by caesarean section were reduction of pain and convenience for family or health professionals. The most frequently reported short term maternal risks of caesarean section were increased time to recover and that it is a less natural way of giving birth. Only one third of the articles mentioned any long term maternal risks or perinatal complications associated with caesarean section. Fear of pain was the main reported reason why women would prefer to deliver by caesarean section. Most of the articles published in Brazilian women's magazines do not use optimal sources of information. The portrayal of caesarean section is mostly balanced, not explicitly in favour of one or another route of delivery, but incomplete and may be leading women to underestimate the maternal/perinatal risks associated with this route of delivery.

  4. 20 years of ClO measurements in the Antarctic lower stratosphere

    Directory of Open Access Journals (Sweden)

    G. E. Nedoluha

    2016-08-01

    Full Text Available We present 20 years (1996–2015 of austral springtime measurements of chlorine monoxide (ClO over Antarctica from the Chlorine Oxide Experiment (ChlOE1 ground-based millimeter wave spectrometer at Scott Base, Antarctica, as well 12 years (2004–2015 of ClO measurements from the Aura Microwave Limb Sounder (MLS. From August onwards we observe a strong increase in lower stratospheric ClO, with a peak column amount usually occurring in early September. From mid-September onwards we observe a strong decrease in ClO. In order to study interannual differences, we focus on a 3-week period from 28 August to 17 September for each year and compare the average column ClO anomalies. These column ClO anomalies are shown to be highly correlated with the average ozone mass deficit for September and October of each year. We also show that anomalies in column ClO are strongly anti-correlated with 30 hPa temperature anomalies, both on a daily and an interannual timescale. Making use of this anti-correlation we calculate the linear dependence of the interannual variations in column ClO on interannual variations in temperature. By making use of this relationship, we can better estimate the underlying trend in the total chlorine (Cly  =  HCl + ClONO2 + HOCl + 2  ×  Cl2 + 2  ×  Cl2O2 + ClO + Cl. The resultant trends in Cly, which determine the long-term trend in ClO, are estimated to be −0.5 ± 0.2, −1.4 ± 0.9, and −0.6 ± 0.4 % year−1, for zonal MLS, Scott Base MLS (both 2004–2015, and ChlOE (1996–2015 respectively. These trends are within 1σ of trends in stratospheric Cly previously found at other latitudes. The decrease in ClO is consistent with the trend expected from regulations enacted under the Montreal Protocol.

  5. 20 years of cosmic muons research performed in IFIN-HH

    Energy Technology Data Exchange (ETDEWEB)

    Mitrica, Bogdan [Horia Hulubei National Institute of Physics and Nuclear Engineering - IFIN HH, Bucharest, P.O.B.MG-6 (Romania)

    2012-11-20

    detailed effects of the direction of EAS incidence relative to the geomagnetic field, depending, in particular, of the primary mass. Based on the results, we can say that WILLI-EAS experiment could be used for testing the hadronic interaction models. Measurements of the high energy muon flux in underground of the salt mine from Slanic Prahova, Romania was performed using a new mobile detector developed in IFIN-HH, Bucharest. Consisting of 2 scintillator plates measuring in coincidence, the detector is installed on a van which facilitates measurements on different positions at surface or in underground. The detector was used to measure muon fluxes in different locations at surface or in underground. The detector was used to measure muon fluxes at different sites of Romania and in the underground of the salt mines from Slanic Prahova, Romania where IFIN-HH has a modern underground laboratory. New methods for the detection of cosmic ray muons are investigated in our institute based on scintillator techniques using optical fiber and MPPC photodyodes.

  6. 20 years' 'Department of Energy Conversion' and its contribution to the use of nuclear energy in the GDR

    International Nuclear Information System (INIS)

    Schramm, G.

    1989-01-01

    The Department of Energy Conversion at the Dresden University of Technology has been founded 20 years ago. After briefly elucidating the tasks of the department, a review of scientific achievements carried out to the use of nuclear energy in the power economy of the GDR in this period is given. Results include specific problems of nuclear technology and machine engineering, measurement technology, automation, process design, thermodynamics as well. Further information may be found in the 100 detailed references quoted. (author)

  7. 20 Years of Publications on Relationship Marketing in Brazil: An Analysis of the 1992 Academic Production a 2012

    Directory of Open Access Journals (Sweden)

    Luiz Henrique Lima Faria

    2014-03-01

    Full Text Available This work, using as sample the ENANPAD`s annals and the periodics RAE and RAUSP, analyzed the academic production on relationship marketing from 1992 to 2012. For this, we used, as basis methodological, six aspects observed in the study de Almeida, Lopes and Pereira (2006, which provided comparisons of results, allowing to build an overview of 20 years of research on relationship marketing in Brazil.    

  8. Insights into Adherence among a Cohort of Adolescents Aged 12–20 Years in South Africa: Reported Barriers to Antiretroviral Treatment

    Directory of Open Access Journals (Sweden)

    Mhairi Maskew

    2016-01-01

    Full Text Available Adolescents experience disproportionately high rates of poor ART outcomes compared to adults despite prolonged use of antiretroviral therapy in Southern African treatment programs, presenting a significant challenge to national attempts to meet the UNAIDS 90-90-90 targets for 2020. This cohort study among adolescents aged 12–20 years accessing ART care at two urban public-sector clinics in Johannesburg between September and November 2013 aimed to identify factors potentially associated with poor attendance at clinic visits. Patients were followed up through routine medical records to identify missed visits (failing to attend clinic within 30 days of scheduled visit date up to 2 years after enrolment. We enrolled 126 adolescents on ART for a median of 6.3 years (IQR: 2.7–8.4. A total of 47 (38% adolescents missed a scheduled visit within 24 months of enrolment. Older adolescents (18–20 years were more likely to miss a visit compared to adolescents aged 12–14 years (risk ratio (RR = 1.72; 95% CI: 1.00–2.95. Those who were identified to have difficulty in taking medication (RR = 1.57; 95% CI: 1.13–2.18 as a barrier to care were more likely to miss a visit compared to adolescents who did not. Awareness of treatment fatigue, challenges to taking ART, and caregiver difficulties is important when considering interventions to improve treatment outcomes among adolescents.

  9. [Changes in the demand for paediatric neurology care in a spanish tertiary care hospital over a 20-year period].

    Science.gov (United States)

    Monge Galindo, L; López-Pisón, J; Samper Villagrasa, P; Peña Segura, J L

    2014-01-01

    The purpose of this study is to determine the profile of the demand for paediatric neurology care in a Spanish tertiary hospital over the past 20 years. We studied epidemiological data, reasons for consultation, diagnoses and complementary tests from all patients examined by our Paediatric Neurology Unit in its 20 years of service (from May 1990 to March 2010). We also reviewed data from patients whose first visit took place within the last five years (2005-2010) and compared them to data obtained from a prior study carried out in this Unit from 1990 to 1995. To compare the first 5 years (group 1) with the last 5 years (group 2), we calculated confidence intervals, P<.05, for the frequency distribution (%) in each category. Main reasons for consultation and principal diagnoses for the 12726 patients evaluated in the 20-year period, as well as results from group 1 (2046 patients) and group 2 (4488 patients) corresponding to first and the last 5 years of activity respectively, are presented with their confidence intervals in a series of tables. Variations in the reasons for consultation, diagnoses and complementary tests over time reflect changes determined by medical, scientific and social progress, and organisational changes specific to each hospital. This explains the difficulty of comparing different patient series studied consecutively, which are even more pronounced between different hospitals. Copyright © 2012 Sociedad Española de Neurología. Published by Elsevier Espana. All rights reserved.

  10. Treatment of Chagas' disease with itraconazole: electrocardiographic and parasitological conditions after 20 years of follow-up.

    Science.gov (United States)

    Apt, Werner; Arribada, Arturo; Zulantay, Inés; Rodríguez, Jorge; Saavedra, Miguel; Muñoz, Andrea

    2013-09-01

    To evaluate cases of chronic Chagas' disease for the long-term effects of treatment with itraconazole on Trypanosoma cruzi infections and the regression or development of ECG abnormalities. In March 1992, we treated 46 patients with chronic Chagas' disease with 6 mg/kg/day of itraconazole for 120 days in a blind evaluation. The patients came from an area of Chile where the disease was endemic and were checked for ECG abnormalities and with xenodiagnosis (XD) or real-time XD-quantitative PCR (XD-qPCR) for Trypanosoma cruzi infection before treatment and once a year for 20 years. Twenty-one patients proved to be uninfected after 20 years and 15 of the patients had a normal ECG. Of the latter cases, 32.6% could be considered cured, although all of them had positive serology. Itraconazole prevents the development of ECG abnormalities, because after 20 years of treatment only 10.86% of patients developed ECG abnormalities (Z = 1.70, P = 0.046). XD-qPCR performed on 16 patients demonstrated 10 cases with XD; these cases correspond to therapy failure, since re-infection was ruled out. In one case, XD-qPCR did not present amplification. Itraconazole is useful in the treatment of chronic Chagas' disease as it prevented the development of ECG abnormalities and cured 32.6% of patients.

  11. Latest climate changes in Romania :tornadoes

    Science.gov (United States)

    Pop, Elena

    2014-05-01

    Latest climate changes in Romania :tornadoes As climate change has been considered a research priority in the European Strategy for enduring development , I have done a detailed research with my students of the new climate change that has been going on in Romania for the past decade. More precisely I have studied together with my students the phenomenon of tornadoes that have seriously affected on some occasions some our our country's locations, such as Facaeni, in the county of Ialomita, in August 2002. A quite unusual phenomenon occurred on that location situated at 44.56 degrees northern latitude and at 27.89 degrees eastern longitude, that caused severe damage to the local environment and three persons lost their lives in the process, as well as other thirty people suffering from bad injuries. The magnitude of that strong phenomenon rose on the Fujita scale at level F3 which implied wing gusts between 252-300 km/ hour . A main cause of occurrence of such a severe weather was the difference in temperature of two huge air masses, one of Polar origin, and other coming from tropical latitudes . Their crossroads was on that precise territory of Romania. The duration of the worst part of the tornado path lasted only for two minutes, but the consequences of its passage were colossal : total destruction of 33 households, and other 395 were partially damaged, 1,000 people afflicted by the devastation and 100 acres of acacia tree forest ripped off the ground. The first ever recorded tornado phenomenon in Romania was around 1894-1896, considered at that time " a freak of nature" was seen as a cloud formation abnormality , an uncontrolled force of nature that had a huge impact , and at the same time, it vanished into "thin air " fast. The most affected areas in Romania by tornadoes are the south-eastern planes where the cloud formations can create fast columns of air rotating up to 500 km/hour. The local people compared the cloud funnels created on the planes to "serpents

  12. A search for sterile neutrinos with the latest cosmological observations

    Energy Technology Data Exchange (ETDEWEB)

    Feng, Lu; Zhang, Jing-Fei [Northeastern University, Department of Physics, College of Sciences, Shenyang (China); Zhang, Xin [Northeastern University, Department of Physics, College of Sciences, Shenyang (China); Peking University, Center for High Energy Physics, Beijing (China)

    2017-06-15

    We report the result of a search for sterile neutrinos with the latest cosmological observations. Both cases of massless and massive sterile neutrinos are considered in the ΛCDM cosmology. The cosmological observations used in this work include the Planck 2015 temperature and polarization data, the baryon acoustic oscillation data, the Hubble constant direct measurement data, the Planck Sunyaev-Zeldovich cluster counts data, the Planck lensing data, and the cosmic shear data. We find that the current observational data give a hint of the existence of massless sterile neutrino (as dark radiation) at the 1.44σ level, and the consideration of an extra massless sterile neutrino can indeed relieve the tension between observations and improve the cosmological fit. For the case of massive sterile neutrino, the observations give a rather tight upper limit on the mass, which implies that actually a massless sterile neutrino is more favored. Our result is consistent with the recent result of neutrino oscillation experiment done by the Daya Bay and MINOS collaborations, as well as the recent result of cosmic ray experiment done by the IceCube collaboration. (orig.)

  13. TEENAGERS (10 - 20 YEARS)

    African Journals Online (AJOL)

    Chantel

    naked eye, but the skin looks greasy. Microcomedones ... The main focus of therapy is to reduce the formation of microcomedones in the sebaceous ... agent or a topical or oral antibiotic. Benzoyl ..... as the skin is generally very dry. Extensive ...

  14. 20 years Rossendorf cyclotron

    International Nuclear Information System (INIS)

    1978-08-01

    On the occasion of the 20th anniversary of initiating of the Rossendorf cyclotron accounts are given of most important works and results in the field of accelerator engineering and utilization of this machine. The reports show the trend of development and actual spectrum of application. The enclosed literature lists give a survey of technical and experimental works at cyclotron. (author)

  15. 20+ years of Inflation

    CERN Document Server

    García-Bellido, J

    2003-01-01

    In this talk I will review the present status of inflationary cosmology and its emergence as the basic paradigm behind the Standard Cosmological Model, with parameters determined today at better than 10% level from CMB and LSS observations. I will also discuss the recent theoretical developments on the process of reheating after inflation and model building based on string theory and D-branes.

  16. 20 years of EUFIC

    DEFF Research Database (Denmark)

    Grunert, Klaus G

    2015-01-01

    Increased interest in responsible and authentic food production and consumption results in more information appearing on food labels. At the same time, the basic principles of consumer food choice do not change: consumer decision-making is mostly simple, fast and based on habit. How can we...

  17. 20 years with Chernobyl

    International Nuclear Information System (INIS)

    2006-01-01

    The newsletter describes briefly the Chernobyl accident and it's consequences. The emphasis is on food production, nutrition and radiation doses in the Norwegian population. Some heath risks are mentioned. Resource and preparedness aspects are briefly discussed

  18. Latest framework to improve vital signs.

    Science.gov (United States)

    Baillie, Jonathan

    2009-08-01

    Greater consistency in NHS signage, coupled with the assurance of a high quality, competitively-priced range of signage and wayfinding products and services, are among the benefits promised to estates and facilities teams UK-wide following the NHS Purchasing and Supply Agency's (NHS PASA) recent launch of a new pan-Government signage framework agreement. Jonathan Baillie reports, and talks to several signage suppliers appointed to the framework about their expertise, skills and recent experience.

  19. Changes in the diagnostic and therapeutic methods for Lemmel′s syndrome over the past 20 years in China

    Directory of Open Access Journals (Sweden)

    ZHU Fengshang

    2018-03-01

    Full Text Available ObjectiveTo investigate the changes in the diagnostic and therapeutic methods for Lemmel′s syndrome over the past 20 years in China, and to provide experience for standardized diagnosis and treatment of this disease. MethodsA retrospective analysis was performed for the clinical data of 23 patients with Lemmel′s syndrome who were diagnosed and treated in Tongji Hospital of Tongji University from January 1998 to June 2017 and 384 patients with Lemmel′s syndrome reported in China during the same period of time (407 patients in total. According to the admission time, the patients were divided into groups A (139 patients admitted from 1998 to 2007 and B (268 patients admitted from 2008 to 2017. The patients′ clinical features, diagnostic and therapeutic methods, and prognosis were recorded. The t-test was used for comparison of normally distributed continuous data between groups, and the Wilcoxon rank sum test was used for comparison of non-normally distributed continuous data between groups, the chi-square test was used for comparison of categorical data between groups. ResultsCompared with group A, group B had significantly higher age of onset (67.8±17.8 vs 62.3±12.3, t=-13.238, P= 0.019 and incidence rate of cholangitis (45.9% vs 32.4%, χ2=6.903, P=0.009. As for diagnostic methods, compared with group A, group B had a significantly higher proportion of patients who used multi-slice spiral CT (MSCT (26.9% vs 8.6%, χ2=18.576, P<0.001, endoscopic ultrasonography (EUS (15.7% vs 5.8%, χ2=8.352, P=0.004, magnetic resonance cholangiopancreatography (MRCP (75.0% vs 33.1%, χ2=67.303, P<0.001, or endoscopic retrograde cholangiopancreatography (ERCP (63.4% vs 36.7%, χ2=26377, P<0.001, while the two groups had a similar false positive rate (22.8% vs 28.1%, χ2=1.385, P=0.239. As for therapeutic methods, compared with group A, group B had a significantly higher proportion of patients who underwent ERCP combined with conservative

  20. A review from the regulatory position of the control of occupational exposure associated with the first 20 years of the United Kingdom commercial nuclear power programme

    International Nuclear Information System (INIS)

    Emmerson, B.W.

    1980-01-01

    Experience gained by the Nuclear Installations Inspectorate (NII) during the past 20 years in the regulatory control of the nuclear power programme is discussed. After discussing control objectives, the principle sources of occupational exposure associated with the nuclear power programme are tabulated from 1962 to 1979. The fuel reprocessing plants give rise to the highest contribution to radiation dose. It is concluded that there is an improving trend in the radiological exposure pattern despite increasing power generation, fuel burn-up and processing plant throughput. The objective of ensuring that individuals do not exceed the statutory dose limits has largely been achieved. However, optimization procedures will probably be used in the future to optimise procedures and thus exposure data for various tasks will be required. (UK)

  1. Nitrous Oxide Abuse and Vitamin B12 Action in a 20-Year-Old Woman: A Case Report.

    Science.gov (United States)

    Duque, Miriam Andrea; Kresak, Jesse L; Falchook, Adam; Harris, Neil S

    2015-01-01

    Herein, we report a case of a 20-year-old (ethnicity not reported) woman with a history of nitrous oxide abuse and clinical symptoms consistent with spinal cord subacute combined degeneration with associated low serum concentrations of vitamin B12, elevated methylmalonic acid levels, and radiologic evidence of demyelination of the dorsal region of the spinal column. The health of the patient improved dramatically with B12 supplementation. In this case, we discuss the interaction of nitrous oxide with the enzymatic pathways involved in the biochemistry of vitamin B12. Copyright© by the American Society for Clinical Pathology (ASCP).

  2. Geostatistical Model-Based Estimates of Schistosomiasis Prevalence among Individuals Aged ≤20 Years in West Africa

    Science.gov (United States)

    Schur, Nadine; Hürlimann, Eveline; Garba, Amadou; Traoré, Mamadou S.; Ndir, Omar; Ratard, Raoult C.; Tchuem Tchuenté, Louis-Albert; Kristensen, Thomas K.; Utzinger, Jürg; Vounatsou, Penelope

    2011-01-01

    Background Schistosomiasis is a water-based disease that is believed to affect over 200 million people with an estimated 97% of the infections concentrated in Africa. However, these statistics are largely based on population re-adjusted data originally published by Utroska and colleagues more than 20 years ago. Hence, these estimates are outdated due to large-scale preventive chemotherapy programs, improved sanitation, water resources development and management, among other reasons. For planning, coordination, and evaluation of control activities, it is essential to possess reliable schistosomiasis prevalence maps. Methodology We analyzed survey data compiled on a newly established open-access global neglected tropical diseases database (i) to create smooth empirical prevalence maps for Schistosoma mansoni and S. haematobium for individuals aged ≤20 years in West Africa, including Cameroon, and (ii) to derive country-specific prevalence estimates. We used Bayesian geostatistical models based on environmental predictors to take into account potential clustering due to common spatially structured exposures. Prediction at unobserved locations was facilitated by joint kriging. Principal Findings Our models revealed that 50.8 million individuals aged ≤20 years in West Africa are infected with either S. mansoni, or S. haematobium, or both species concurrently. The country prevalence estimates ranged between 0.5% (The Gambia) and 37.1% (Liberia) for S. mansoni, and between 17.6% (The Gambia) and 51.6% (Sierra Leone) for S. haematobium. We observed that the combined prevalence for both schistosome species is two-fold lower in Gambia than previously reported, while we found an almost two-fold higher estimate for Liberia (58.3%) than reported before (30.0%). Our predictions are likely to overestimate overall country prevalence, since modeling was based on children and adolescents up to the age of 20 years who are at highest risk of infection. Conclusion/Significance We

  3. [Methodologies of publications in the Revista de Investigación Clínica during the last 20 years].

    Science.gov (United States)

    López-Jiménez, F; Borovoy, J

    1997-01-01

    To characterize the clinical research methods published in the Revista de Investigación Clínica for the past 20 years. Comparative study of methods used in the RIC articles published in 3-years periods representing three decades (1972-74, 1982-84, 1992-94). Out of 273 original papers, 218 (80%) were of clinical research. There was an increased percentage of longitudinal vs cross-sectional studies, with cohort and randomized clinical trials showing the largest increase. The total number of research manuscripts also increased. The clinical research methods of the papers in the RIC have shown an increased rate of designs with a higher scientific value.

  4. A 20-year-old man with large gastric lipoma--imaging, clinical symptoms, pathological findings and surgical treatment.

    Science.gov (United States)

    Kapetanakis, Stylianos; Papathanasiou, Jiannis; Fiska, Aliki; Ververidis, Athanasios; Dimitriou, Thespis; Hristov, Zheliazko; Paskalev, George

    2010-01-01

    A broad search of the available literature yielded no other report of gastric lipoma of that size (13.5 x 6.5 x 4.5 cm) at this early age. The patient (a 20-year-old man with giant lipoma in the anterior gastric wall) presented with haematemesis and melena after excessive alcohol consumption. Gastric resection was performed. At 5-year follow up the patient is healthy and doing well. Epidemiology of gastric lipoma, the differential diagnosis, means of diagnosis and treatment are discussed.

  5. Use of Pneumococcal Disease Epidemiology to Set Policy and Prevent Disease during 20 Years of the Emerging Infections Program.

    Science.gov (United States)

    Moore, Matthew R; Whitney, Cynthia G

    2015-09-01

    Two decades ago, the Emerging Infections Program of the US Centers for Disease Control and Prevention implemented what seemed like a simple yet novel idea: a population- and laboratory-based surveillance system designed to identify and characterize invasive bacterial infections, including those caused by Streptococcus pneumoniae. This system, known as Active Bacterial Core surveillance, has since served as a flexible platform for following trends in invasive pneumococcal disease and studying vaccination as the most effective method for prevention. We report the contributions of Active Bacterial Core surveillance to every pneumococcal vaccine policy decision in the United States during the past 20 years.

  6. Journal of Innovation in Health Informatics: building on the 20-year history of a BCS Health peer review journal

    Directory of Open Access Journals (Sweden)

    Simon de Lusignan

    2015-02-01

    Full Text Available After 20-years as Informatics in Primary Care the journal is renamed Journal of Innovation in Health Informatics. The title was carefully selected to reflect that:(1 informatics provides the opportunity to innovate rather than simply automates;(2 implementing informatics solutions often results in unintended consequences, and many implementations fail and benefits and innovations may go unrecognised;(3 health informatics is a boundary spanning discipline and is by its very nature likely to give rise to innovation.Informatics is an innovative science, and informaticians need to innovate across professional and discipline boundaries.

  7. [Parvovirus B19 infection as the cause of hepatitis and neutrophil granulocytosis in a 20-year old woman].

    Science.gov (United States)

    Wiggers, H; Rasmussen, L H; Møller, A

    1995-10-23

    A case of Parvovirus B19 infection (erythema infectiosum) in a 20 year old woman is presented. The patient presented with fever, arthritis in one knee, neutrophil granulocytosis and biochemical evidence of hepatitis. Serological evidence of Parvovirus B19 infection was found as the only explanation of the clinical picture. Hepatitis was due to Parvovirus B19 infection as there was no serological evidence of EBV or CMV reactivation. Neutrophil granulocytosis and thrombocytosis were found and were probably due to an active bone marrow in the recovery phase of bone marrow aplasia.

  8. Latest LHCb measurements of Electroweak Boson Production in Run-1

    CERN Document Server

    CERN. Geneva

    2015-01-01

    We present the latest LHCb measurements of forward Electroweak Boson Production using proton-proton collisions recorded in LHC Run-1. The seminar shall discuss measurements of the 8 TeV W & Z boson production cross-sections. These results make use of LHCb's excellent integrated luminosity determination to provide constraints on the parton distribution functions which describe the inner structure of the proton. These LHCb measurements probe a region of phase space at low Bjorken-x where the other LHC experiments have limited sensitivity. We also present measurements of cross-section ratios, and ratios of results in 7 TeV and 8 TeV proton-proton collisions. These results provide precision tests of the Standard Model. The seminar shall also present a measurement of the forward-backward asymmetry (A_FB) in Z boson decays to two muons. This result allows for precision tests of the coupling of the Z boson to left and right handed particles, providing sensitivity to the effective weak mixing angle (...

  9. Latest Developments from the S-DALINAC*

    CERN Document Server

    Brunken, M; Gopych, P M; Gräf, H D; Khodyachykh, S; Kostial, S; Laier, U; Lenhardt, A; Loos, H; Mühl, J; Platz, M; Richter, A; Richter, S; Schweizer, B; Stascheck, A; Titze, O; Watzlawik, S; Döbert, Steffen

    2000-01-01

    The S-DALINAC is a 130 MeV superconducting recirculating electron accelerator serving several nuclear and radiation physics experiments as well as driving an infrared free-electron laser. A system of normal conducting rf resonators for noninvasive beam position and current measurement was established. For the measurement of gamma-radiation inside the accelerator cave a system of Compton diodes has been developed and tested. Detailed investigations of the transverse phasespace were carried out with a tomographical reconstruction method of optical transition radiation spots. The method can be applied also to non-Gaussian phasespace distributions. The results are in good accordance with simulations. To improve the quality factor of the superconducting 3 GHz cavities, an external 2K testcryostat was commissioned. The influence of electro-chemical polishing and magnetic shielding is currently under investigation. A digital rf-feedback-system for the accelerator cavities is being developed in order to improve the e...

  10. ICARUS T600: Latest physics results

    International Nuclear Information System (INIS)

    Zani, A.

    2014-01-01

    The ICARUS T600 detector is the largest Liquid Argon (LAr) Time Projection Chamber (TPC) ever built and operated to date. The detector, assembled underground in the Hall B of the Gran Sasso Laboratory (LNGS), has been collecting neutrino events with the CERN to Gran Sasso (CNGS) beam and from cosmic rays from May 2010 to June 2013. The ICARUS excellent spatial and calorimetric resolution, coupled to very refined 3D event reconstruction techniques, allows to search, among others, for ν μ →ν e transitions which may be related to the 'LSND anomaly'. Though no evidence of this is detected, an important region of the parameter space remains unexplored. For this reason the joint ICARUS-NESSiE collaboration is proposing an experiment, at the new foreseen CERN-SPS neutrino beam facility (CENF), to solve the sterile neutrino puzzle.

  11. Latest results from XENON100 data

    International Nuclear Information System (INIS)

    Scotto Lavina, L.

    2014-01-01

    XENON100 is the current phase of the XENON dark matter program, which aims for the direct detection of WIMPs with liquid xenon time-projection chambers. We present the status of the experiment after 224.6 live days taken in 2011 and 2012 during which the detector successfully improved in terms of more calibration data, higher xenon purity, lower threshold and better background removal. The analysis has yielded no evidence for dark matter interactions. The status of the next generation XENON1T detector will be briefly described. The goal of XENON1T is to increase the fiducial volume by a factor 10 and reduce the background noise by a factor 100

  12. The impact of lean production on musculoskeletal and psychosocial risks: an examination of sociotechnical trends over 20 years.

    Science.gov (United States)

    Koukoulaki, Theoni

    2014-03-01

    This paper provides an extensive review of studies carried out in lean production environments in the last 20 years. It aims to identify the effects of lean production (negative or positive) on occupational health and related risk factors. Thirty-six studies of lean effects were accepted from the literature search and sorted by sector and type of outcome. Lean production was found to have a negative effect on health and risk factors; the most negative outcomes being found in the earliest studies in the automotive industry. However, examples of mixed and positive effects were also found in the literature. The strongest correlations of lean production with stress were found for characteristics found in Just-In-Time production that related to reduced cycle time and reduction of resources. Increased musculoskeletal risk symptoms were related to increases of work pace and lack of recovery time also found in Just-In-Time systems. An interaction model is developed to propose a pathway from lean production characteristics to musculoskeletal and psychosocial risk factors and also positive outcomes. An examination is also made of the changing focus of studies investigating the consequences of lean production over a 20-year period. Theories about the effects of lean production have evolved from a conceptualization that it is an inherently harmful management system, to a view that it can have mixed effects depending on the management style of the organization and the specific way it is implemented. Copyright © 2013 Elsevier Ltd and The Ergonomics Society. All rights reserved.

  13. The Pu'u 'O'o-Kupaianaha Eruption of Kilauea Volcano, Hawaii: The First 20 Years

    Science.gov (United States)

    Heliker, Christina C.; Swanson, Donald A.; Takahashi, Taeko Jane

    2003-01-01

    The Pu'u 'O'o-Kupaianaha eruption started on January 3, 1983. The ensuing 20-year period of nearly continuous eruption is the longest at Kilauea Volcano since the famous lava-lake activity of the 19th century. No rift-zone eruption in more than 600 years even comes close to matching the duration and volume of activity of these past two decades. Fortunately, such a landmark event came during a period of remarkable technological advancements in volcano monitoring. When the eruption began, the Global Positioning System (GPS) and the Geographic Information System (GIS) were but glimmers on the horizon, broadband seismology was in its infancy, and the correlation spectrometer (COSPEC), used to measure SO2 flux, was still very young. Now, all of these techniques are employed on a daily basis to track the ongoing eruption and construct models about its behavior. The 12 chapters in this volume, written by present or past Hawaiian Volcano Observatory staff members and close collaborators, celebrate the growth of understanding that has resulted from research during the past 20 years of Kilauea's eruption. The chapters range widely in emphasis, subject matter, and scope, but all present new concepts or important modifications of previous ideas - in some cases, ideas long held and cherished.

  14. A 20-Year multi-followup longitudinal study assessing whether antipsychotic medications contribute to work functioning in schizophrenia.

    Science.gov (United States)

    Harrow, Martin; Jobe, Thomas H; Faull, Robert N; Yang, Jie

    2017-10-01

    To assess the long-term effectiveness of antipsychotic medications in facilitating work functioning in patients with schizophrenia we conducted longitudinal multifollowup research on 139 initially psychotic patients. The 70 patients with schizophrenia and 69 initially psychotic mood disordered control patients were followed up 6 times over 20 years. We compared the influence on work functioning of patients with schizophrenia continuously prescribed antipsychotics with patients with schizophrenia not prescribed antipsychotics, using statistical controls for inter-subject differences. While antipsychotics reduce or eliminate flagrant psychosis for most patients with schizophrenia at acute hospitalizations, four years later and continually until the 20 year followups, patients with schizophrenia not prescribed antipsychotics had significantly better work functioning. The work performance of the patients who were continuously prescribed antipsychotics was at a low rate and did not improve over time. Multiple other factors also interfere with work functioning. The data suggest that some patients with schizophrenia not prescribed antipsychotics for prolonged periods can function relatively well. Multiple other factors are associated with poor post-hospital work performance. The longitudinal data raise questions about prolonged treatment of schizophrenia with antipsychotic medications. Copyright © 2017 Elsevier B.V. All rights reserved.

  15. A longitudinal follow-up of posttraumatic stress: from 9 months to 20 years after a major road traffic accident

    Directory of Open Access Journals (Sweden)

    Rydelius Per-Anders

    2011-03-01

    Full Text Available Abstract Background Although road traffic accidents (RTA are a major cause of injury and a cause of posttraumatic stress (PTS in the aftermath, little is known about the long-term psychological effects of RTA. Methods This prospective longitudinal study assessed long-term PTS, grief, and general mental health after a bus carrying 23 sixth-grade schoolchildren crashed on a school outing and 12 children died. Directly affected (i.e., children in the crash and indirectly affected children (i.e., all pupils in the sixth grade who were not in the crash were surveyed at 9 months (N = 102, 4 years (N = 51, and 20 years (N = 40 after the event. Psychological distress was assessed by single items, including sadness, avoidance, intrusions, and guilt. After 20 years, PTS was assessed by the Impact of Event Scale-Revised. Results Stress reactions were prevalent 9 months after the event, with sadness (69% and avoidance (59% being highly represented in both directly and indirectly affected groups, whereas, nightmares (60% and feelings of guilt (50% were only frequent in those directly affected. The frequency of sadness and avoidance decreased after 4 years in the indirectly exposed (ps p = .003, but not decreased general mental health (p = .14, than those indirectly affected. Conclusions The limitations preclude assertive conclusions. Nonetheless, the findings corroborate previous studies reporting traumatic events are associated with long-term PTS, but not with decreased general mental health.

  16. Weight Suppression Predicts Bulimic Symptoms at 20-year Follow-up: The Mediating Role of Drive for Thinness

    Science.gov (United States)

    Bodell, Lindsay P.; Brown, Tiffany A.; Keel, Pamela K.

    2016-01-01

    Weight suppression predicts the onset and maintenance of bulimic syndromes. Despite this finding, no study has examined psychological mechanisms contributing to these associations using a longitudinal design. Given societal pressures to be thin and an actual history of higher weight, it is possible that greater weight suppression contributes to increased fear of gaining weight and preoccupation with being thin, which increase vulnerability to eating disorders. The present study investigated whether greater drive for thinness mediates associations between weight suppression and bulimic symptoms over long-term follow-up. Participants were women (n = 1190) and men (n = 509) who completed self-report surveys in college and 10- and 20- years later. Higher weight suppression at baseline predicted higher bulimic symptoms at 20-year follow-up (p symptoms, body mass index, and drive for thinness. Increased drive for thinness at 10-year follow-up mediated this effect. Findings highlight the long-lasting effect of weight suppression on bulimic symptoms and suggest that preoccupation with thinness may help maintain this association. Future studies would benefit from incorporating other hypothesized consequences of weight suppression, including biological factors, into risk models. PMID:27808544

  17. Autopsy-determined causes of death following organ transplantation in 25 patients aged 20 years or younger.

    Science.gov (United States)

    Rose, Alan G

    2003-01-01

    This study aims to examine the autopsy-determined principal and proximate causes of death in 25 patients aged 20 years or younger who died during the 10-year period from 1990 to 1999 after receiving an organ transplant at the University of Minnesota/Fairview-University Medical Center. The autopsy records of this institution were examined for organ transplant recipients who were aged 20 years or younger at the time of their death. In each case, after review of the clinical and pathological data, the principle cause of death (PCOD), as well as the proximate cause of death (PXCOD) were noted. A total of 25 recipient patients were identified (five heart, five lung, five kidney and 10 liver transplants). Seven patients died 30 days or less post-operatively and 18 died thereafter. The following categories of PCOD were encountered: operative/technical complications 28%, most (6/7) being associated with liver transplantation. Infection (24%) and chronic rejection (12%) were other important PCOD. Respiratory complications accounted for 47% of the PCOD. The following categories of PXCOD were noted: technical problems 16%, pulmonary pathology 24%, miscellaneous 32%, acute rejection 4% and nil 20%. This study revealed that technical problems in liver transplants were an important PCOD; respiratory complications and chronic rejection were additional major causes of mortality in this young age group of transplant recipients. Pulmonary pathology and technical problems were the commonest specific groups contributing to the PXCOD.

  18. Milk Intake at Midlife and Cognitive Decline over 20 Years. The Atherosclerosis Risk in Communities (ARIC) Study.

    Science.gov (United States)

    Petruski-Ivleva, Natalia; Kucharska-Newton, Anna; Palta, Priya; Couper, David; Meyer, Katie; Graff, Misa; Haring, Bernhard; Sharrett, Richey; Heiss, Gerardo

    2017-10-17

    Background : Faster rates of cognitive decline are likely to result in earlier onset of cognitive impairment and dementia. d-galactose, a derivative of lactose, is used in animal studies to induce neurodegeneration. Milk is the primary source of lactose in the human diet, and its effects on cognitive decline have not been fully evaluated. Objective : Assess the association of milk intake with change in cognitive function over 20 years. Methods : A total of 13,751 participants of the Atherosclerosis Risk in Communities (ARIC) cohort completed a food frequency questionnaire and three neurocognitive evaluations from 1990 through 2013. Two single nucleotide polymorphisms (SNPs) were used to determine lactase persistence (LCT-13910 C/T for Whites and LCT-14010 G/C for Blacks). Mixed-effects models were used to study the association of milk intake with cognitive change. Multiple imputations by chained equations were used to account for attrition. Results : Milk intake greater than 1 glass/day was associated with greater decline in the global z-score over a 20-year period. The difference in decline was 0.10 (95% CI: 0.16, 0.03) z-scores, or an additional 10% decline, relative to the group reporting "almost never" consuming milk. Conclusions : Replication of these results is warranted in diverse populations with greater milk intake and higher variability of lactase persistence genotype.

  19. Milk Intake at Midlife and Cognitive Decline over 20 Years. The Atherosclerosis Risk in Communities (ARIC Study

    Directory of Open Access Journals (Sweden)

    Natalia Petruski-Ivleva

    2017-10-01

    Full Text Available Background: Faster rates of cognitive decline are likely to result in earlier onset of cognitive impairment and dementia. d-galactose, a derivative of lactose, is used in animal studies to induce neurodegeneration. Milk is the primary source of lactose in the human diet, and its effects on cognitive decline have not been fully evaluated. Objective: Assess the association of milk intake with change in cognitive function over 20 years. Methods: A total of 13,751 participants of the Atherosclerosis Risk in Communities (ARIC cohort completed a food frequency questionnaire and three neurocognitive evaluations from 1990 through 2013. Two single nucleotide polymorphisms (SNPs were used to determine lactase persistence (LCT-13910 C/T for Whites and LCT-14010 G/C for Blacks. Mixed-effects models were used to study the association of milk intake with cognitive change. Multiple imputations by chained equations were used to account for attrition. Results: Milk intake greater than 1 glass/day was associated with greater decline in the global z-score over a 20-year period. The difference in decline was 0.10 (95% CI: 0.16, 0.03 z-scores, or an additional 10% decline, relative to the group reporting “almost never” consuming milk. Conclusions: Replication of these results is warranted in diverse populations with greater milk intake and higher variability of lactase persistence genotype.

  20. Managing Type 1 Diabetes: Trends and Outcomes over 20 years of Follow-up in the Wisconsin Diabetes Registry Cohort

    Science.gov (United States)

    Palta, Mari; LeCaire, Tamara

    2009-01-01

    Context The WDRS is a Wisconsin cohort with type 1 diabetes, diagnosed 1987–1992 and actively followed. The study provides patients and health care professionals with better prognostic information and helps identify aspects of diabetes management that need improvement. Objective To describe diabetes management and acute and chronic complications from the time of diagnosis. Design and setting All incident cases diagnosed at age ≤30 in 28 counties were eligible and 590 enrolled. A baseline interview, blood sample kits, biannual/annual questionnaires and study examinations at 4, 7, 9, 14 and 20 year's duration were administered. Main outcome measures Diabetes management indicators, general health, and acute and chronic complications. Results Glycemic control was poor in adolescence, but improved with age. A high percentage of individuals do not meet treatment standards for blood pressure and lipid profile. Self reported health deteriorated with age, and BMI was similar to that of the general U.S. population. Chronic complications were present at 15–20 years duration, but tended to be relatively mild. Conclusion There is room for improvement in diabetes management, especially in meeting goals for blood pressure and lipid profile. Nonetheless, individuals with type 1 diabetes can be offered a more optimistic prognosis than in the past. PMID:19743752

  1. Trends and changes in research on the psychology of physical activity across 20 years: a quantitative analysis of 10 journals.

    Science.gov (United States)

    Rhodes, Ryan E; Nasuti, Gabriella

    2011-01-01

    To investigate content of the psychology of physical activity research over the past 20 years. Volumes of 10 journals, identified by impact factor and relevance to physical activity were audited every other year, during the period of 1990-2008. Inclusion criteria were studies that measured a physical activity outcome, and/or a psychological outcome as a result of physical activity. Data were extracted and coded based on 15 factors. The review yielded 889 studies for analysis. Total volume of studies (from 127 in the 1990s to 762 in the 2000s), and the proportionate content space allotted to journals has increased significantly across 20 years (effect size w=0.24) (Cohen, 1992). Many study characteristics (assessment of minority/high-risk groups, self-report measurement, cross-sectional designs) have not changed. There was evidence, however, of less growth in research among older adults and young children (effect size w=0.15) compared to other age groups (effect size w=0.24), a move from pure measurement studies (effect size w=0.21) to descriptive research (effect size w=0.27), and considerable growth in environmental correlates research across time (effect size w=0.41) in the 10 journals sampled. The behavioral science of physical activity has clearly increased in prominence and volume among the 10 journals sampled, but methodological characteristics of research could be improved in the future. Copyright © 2011 Elsevier Inc. All rights reserved.

  2. Weight change after 20 years of age and the incidence of dyslipidemia: a cohort study of Japanese male workers.

    Science.gov (United States)

    Sogabe, N; Sawada, S S; Lee, I-M; Kawakami, R; Ishikawa-Takata, K; Nakata, Y; Mitomi, M; Noguchi, J; Tsukamoto, K; Miyachi, M; Blair, S N

    2016-06-01

    While heavier weight is known to increase the incidence of dyslipidemia, limited data are available on the relationship between weight gain and its development. A total of 2647 males were categorized into the following four groups according to the difference between their self-reported weight at 20 years of age and their measured weight in 1994-95: a loss of ≥5% (decrease), loss of dyslipidemia were determined using logistic regression models. A total of 1342 participants developed dyslipidemia during the follow-up period. The 'increase' and 'sizable increase' groups had odds ratios for the incidence of dyslipidemia of 1.97 (95% CI, 1.59-2.45) and 2.68 (2.15-3.34), respectively, demonstrating that there was a significant dose-response association between weight gain since 20 years of age and the incidence of dyslipidemia (P dyslipidemia could be prevented by avoiding weight gain in adulthood. © The Author 2015. Published by Oxford University Press on behalf of Faculty of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  3. Ginkgo Biloba Extract and Long-Term Cognitive Decline: A 20-Year Follow-Up Population-Based Study

    Science.gov (United States)

    Amieva, Hélène; Meillon, Céline; Helmer, Catherine; Barberger-Gateau, Pascale; Dartigues, Jean François

    2013-01-01

    Background Numerous studies have looked at the potential benefits of various nootropic drugs such as Ginkgo biloba extract (EGb761®; Tanakan®) and piracetam (Nootropyl®) on age-related cognitive decline often leading to inconclusive results due to small sample sizes or insufficient follow-up duration. The present study assesses the association between intake of EGb761® and cognitive function of elderly adults over a 20-year period. Methods and Findings The data were gathered from the prospective community-based cohort study ‘Paquid’. Within the study sample of 3612 non-demented participants aged 65 and over at baseline, three groups were compared: 589 subjects reporting use of EGb761® at at least one of the ten assessment visits, 149 subjects reporting use of piracetam at one of the assessment visits and 2874 subjects not reporting use of either EGb761® or piracetam. Decline on MMSE, verbal fluency and visual memory over the 20-year follow-up was analysed with a multivariate mixed linear effects model. A significant difference in MMSE decline over the 20-year follow-up was observed in the EGb761® and piracetam treatment groups compared to the ‘neither treatment’ group. These effects were in opposite directions: the EGb761® group declined less rapidly than the ‘neither treatment’ group, whereas the piracetam group declined more rapidly (β = −0.6). Regarding verbal fluency and visual memory, no difference was observed between the EGb761® group and the ‘neither treatment’ group (respectively, β = 0.21 and β = −0.03), whereas the piracetam group declined more rapidly (respectively, β = −1.40 and β = −0.44). When comparing the EGb761® and piracetam groups directly, a different decline was observed for the three tests (respectively β = −1.07, β = −1.61 and β = −0.41). Conclusion Cognitive decline in a non-demented elderly population was lower in subjects who reported using EGb761® than in

  4. Ginkgo biloba extract and long-term cognitive decline: a 20-year follow-up population-based study.

    Directory of Open Access Journals (Sweden)

    Hélène Amieva

    Full Text Available Numerous studies have looked at the potential benefits of various nootropic drugs such as Ginkgo biloba extract (EGb761®; Tanakan® and piracetam (Nootropyl® on age-related cognitive decline often leading to inconclusive results due to small sample sizes or insufficient follow-up duration. The present study assesses the association between intake of EGb761® and cognitive function of elderly adults over a 20-year period.The data were gathered from the prospective community-based cohort study 'Paquid'. Within the study sample of 3612 non-demented participants aged 65 and over at baseline, three groups were compared: 589 subjects reporting use of EGb761® at at least one of the ten assessment visits, 149 subjects reporting use of piracetam at one of the assessment visits and 2874 subjects not reporting use of either EGb761® or piracetam. Decline on MMSE, verbal fluency and visual memory over the 20-year follow-up was analysed with a multivariate mixed linear effects model. A significant difference in MMSE decline over the 20-year follow-up was observed in the EGb761® and piracetam treatment groups compared to the 'neither treatment' group. These effects were in opposite directions: the EGb761® group declined less rapidly than the 'neither treatment' group, whereas the piracetam group declined more rapidly (β = -0.6. Regarding verbal fluency and visual memory, no difference was observed between the EGb761® group and the 'neither treatment' group (respectively, β = 0.21 and β = -0.03, whereas the piracetam group declined more rapidly (respectively, β = -1.40 and β = -0.44. When comparing the EGb761® and piracetam groups directly, a different decline was observed for the three tests (respectively β = -1.07, β = -1.61 and β = -0.41.Cognitive decline in a non-demented elderly population was lower in subjects who reported using EGb761® than in those who did not. This effect may be a specific medication

  5. 20 Years of standard patch testing in an eczema population with focus on patients with multiple contact allergies

    DEFF Research Database (Denmark)

    Carlsen, Berit Christina; Menné, Torkil; Johansen, Jeanne Duus

    2007-01-01

    Results of standard patch tests performed with the same methodology in one centre are rarely available over a large time span. This gives the unique opportunity to study not only prevalence but also persistency of contact allergy and characterize subpopulations. The objectives were to investigate...... sensitivity rates and persistencies of patch test results and characterize patients with multiple contact allergies. A 20-year retrospective database-based study of 14 998 patients patch tested with the European Standard Series was performed. 34.5% were sensitized, primarily women. Sensitivity to nickel......(Me)isothiazolinone, and primin and poor for paraben mix. 5.1% were multiple allergic, primarily women, and 90% got diagnosed by the first test. Frequency of multiple allergies increased with age. More multiple- than mono/double-allergic patients were tested multiple times. Persistency and sensitivity rates in a Danish eczema...

  6. Has the incidence of radiation-induced bowel damage following treatment of uterine carcinoma changed in the last 20 years

    International Nuclear Information System (INIS)

    Allen-Mersh, T.C.; Wilson, E.J.; Hope-Stone, H.F.; Mann, C.V.

    1986-01-01

    Radiation-induced bowel damage occurred in 4.3% of patients treated primarily by irradiation for uterine carcinoma during the period 1962-1982. There has been a progressive rise in the incidence of radiation damage and radiation-induced rectovaginal fistula during this 20-year period. Radiation from intracavitary sources was a contributory factor in 92% of injured cases. The rising incidence of bowel damage in our patients may be due to an increase in the number of patients receiving a high rectal dose from the intracavitary source. There was a significantly (P<0.01) higher incidence of radiation injury in cases of cervical carcinoma compared to endometrical carcinoma. This was because cervical carcinoma tended to present at a more advanced stage than endometrial carcinoma and was more frequently treated with combined external and intracavitary irradiation. There was no significant increase in the incidence of complications among patients undergoing hysterectomy. (author)

  7. A longer stay for the kissing disease: epidemiology of bacterial tonsillitis and infectious mononucleosis over a 20-year period.

    Science.gov (United States)

    Lennon, P; Saunders, J; Fenton, J E

    2013-02-01

    Anecdotally, infectious mononucleosis is considered a more severe infection than bacterial tonsillitis, requiring a longer hospital stay. However, there is little in the literature comparing the epidemiology of the two conditions. This study aimed to compare the epidemiology of bacterial tonsillitis and infectious mononucleosis, in particular any differences in the length of in-patient stay. The hospital in-patient enquiry system was used to analyse patients admitted with bacterial tonsillitis and infectious mononucleosis between 1990 and 2009 inclusive. There was a total of 3435 cases over the 20 years: 3064 with bacterial tonsillitis and 371 with infectious mononucleosis. The mean length of stay was 3.22 days for bacterial tonsillitis and 4.37 days for infectious mononucleosis. The median length of stay for each condition was compared using the Mann-Whitney U non-parametric test, and a significant difference detected (p mononucleosis have a significantly longer stay in hospital than those with bacterial tonsillitis.

  8. Intractable radiation pericarditis and pleuritis developed 20 years after postoperative radiotherapy in a case with breast cancer

    Energy Technology Data Exchange (ETDEWEB)

    Tsuji, Misa; Shintani, Uichirou; Ohmoto, Yasuhiro; Isshiki, Noriyuki; Tanaka, Tsuyoshi; Kitamura, Masami; Kato, Shigetake; Misaki, Moriharu [Mie National Central Hospital, Hisai (Japan); Shouin, Hiroshi

    1999-01-01

    We reported a 64-year-old woman with radiation-related intractable pericarditis and pleuritis which developed 20 years after radiotherapy. She underwent a left total mastectomy for a breast cancer and 50 Gy of radiotherapy postoperatively at the age of 43. She was admitted to our hospital because of facial edema and dyspnea. A chest roentgenogram on admission showed massive bilateral pleural effusion and a echocardiography revealed massive pericardial effusion. Though the symptoms of heart failure subsided after the administration of moderate diuretics and cardiotonics, the pleural effusion and pericardial effusion persisted and, she became worse and died. The histological findings at autopsy, showed chronic fibrous pericarditis with marked pericardial thickening, fibrous pleuritis and myocarditis. These findings were compatible with those of previously reported radiation-induced heart disease. We reported a case of pleuritis and pericarditis probably caused by radiation therapy. A long term observation is necessary for the radiation-related heart disease. (author)

  9. Very long-term results (more than 20 years) of valve repair with carpentier's techniques in nonrheumatic mitral valve insufficiency.

    Science.gov (United States)

    Braunberger, E; Deloche, A; Berrebi, A; Abdallah, F; Celestin, J A; Meimoun, P; Chatellier, G; Chauvaud, S; Fabiani, J N; Carpentier, A

    2001-09-18

    Mitral valve repair is considered the gold standard in surgery of degenerative mitral valve insufficiency (MVI), but the long-term results (>20 years) are unknown. We reviewed the first 162 consecutive patients who underwent mitral valve repair between 1970 and 1984 for MVI due to nonrheumatic disease. The cause of MVI was degenerative in 146 patients (90%) and bacterial endocarditis in 16 patients (10%). MVI was isolated or, in 18 cases, associated with tricuspid insufficiency. The mean age of the 162 patients (104 men and 58 women) was 56+/-10 years (age range 22 to 77 years). New York Heart Association functional class was I, II, III, and IV in 2%, 39%, 52%, and 7% of patients, respectively. The mean cardiothoracic ratio was 0.58+/-0.07 (0.4 to 0.8), and 72 (45%) patients had atrial fibrillation. Valve analysis showed that the main mechanism of MVI was type II Carpentier's functional classification in 152 patients. The leaflet prolapse involved the posterior leaflet in 93 patients, the anterior leaflet in 28 patients, and both leaflets in 31 patients. Surgical technique included a Carpentier's ring annuloplasty in all cases, a valve resection in 126 patients, and shortening or transposition of chordae in 49 patients. During the first postoperative month, there were 3 deaths (1.9%) and 3 reoperations (2 valve replacements and 1 repeat repair [1.9%]). Six patients were lost to follow-up. The remaining 151 patients with mitral valve repair were followed during a median of 17 years (range 1 to 29 years; 2273 patient-years). The 20-year Kaplan-Meier survival rate was 48% (95% CI 40% to 57%), which is similar to the survival rate for a normal population with the same age structure. The 20-year rates were 19.3% (95% CI 11% to 27%) for cardiac death and 26% (95% CI 17% to 35%) for cardiac morbidity/mortality (including death from a cardiac cause, stroke, and reoperation). During the 20 years of follow-up, 7 patients were underwent surgery at 3, 7, 7, 8, 8, 10, or 12

  10. The changes of subtypes in pediatric diabetes and their clinical and laboratory characteristics over the last 20 years

    Directory of Open Access Journals (Sweden)

    Eun Byul Kwon

    2016-06-01

    Full Text Available PurposeWe studied the changes in subtypes of diabetes mellitus (DM in children and evaluated the characteristics of each group over the past 20 years. In addition, we also examined the correlation between the glycated hemoglobin (HbA1c values at the time of diagnosis and lipid profiles.MethodsThe patients were divided into 2 groups: there were a total of 190 patients under 20 years of age firstly diagnosed with DM in Ajou University Hospital. The patients in groups I and II were diagnosed from September 1995 to December 2004 and from January 2005 to April 2014, respectively.ResultsThe characteristics were compared between the 2 groups of patients. The result showed an increase in percentage of type 2 diabetes and maturity onset diabetes of the young (MODY patients between the 2 groups. HbA1c and total cholesterol level had statistical significances to explain increasing the low-density lipoprotein cholesterol level among age, HbA1c, total cholesterol level, and z-scores of weight and body mass index (BMI in type 2 diabetes. R-square was 0.074. However, z-score of BMI and total cholesterol level, not HbA1c, had statistical significances in type 1 diabetic patients. R-square was 0.323.ConclusionThe increase in the proportions of both type 2 diabetes and MODY in the last 10 years needed to be reminded when diagnosing the subtypes of DM, and the dyslipidemia should be attended more as a common problem of pediatric diabetic patients.

  11. Analysis of the Indicence and Survival of Female Breast Cancer Patients in Beijing Over a 20-Year Period

    Institute of Scientific and Technical Information of China (English)

    Qijun Wang; Weixing Zhu; Xiumei Xing; Chenxu Qu

    2006-01-01

    OBJECTIVE To provide evidence for breast cancer prevention and control through epidemiological analysis of the incidence, mortality and survival rate of female breast cancer patients in Beijing.METHODS The female registration data in the Beijing urban area from 1982 to 2001 were retrospectively reviewed. The incidence, mortality and survival rate of female breast cancer patients were analyzed using routine and life-table statistical methods.RESULTS During the period of 1982 to 2001, there was a trend of an average annual increase of female breast cancer incidence of 4.6% in urban Beijing, and of 4.9% in the world-population standardized incidence.The epidemiological features of urban Beijing female breast cancer showed:(1)The incidence distribution of different age groups from 25 to 80 years elevated with two peaks at ages of 45~ and 70~ years; (2)There was an elevation in each age group over the last 20 years; (3)The incidence rate at ages of 35 to 64 reached 95.3/105, causing breast cancer to become the number one cancer in females. The changes in the survival rate showed the following: the 5-year observed survival rate (OSR)increased from 62.0% in 1982~1983 to 68.7% in 1987~1988, and the relative-survival rate (RSR) increased from 66.3% to 74.2%. The 10-year OSR and RSR in 1987~1988 were 60.3% and 65.1%, and at 15 years 57.5% and 61.3%, respectively. The mortality rate of breast cancer patients fluctuated from 8 to 10 per 105 population over the 20 years of study.CONCLUSION There is a trend of an annual increase in female breast cancer in Beijing. The 5-year survival is being improved gradually while the mortality remains stable. The results demonstrate that the principles of "early prevention, diagnosis and treatment" for breast cancer are effective in Beijing.

  12. One-leg hop kinematics 20 years following anterior cruciate ligament rupture: Data revisited using functional data analysis.

    Science.gov (United States)

    Hébert-Losier, Kim; Pini, Alessia; Vantini, Simone; Strandberg, Johan; Abramowicz, Konrad; Schelin, Lina; Häger, Charlotte K

    2015-12-01

    Despite interventions, anterior cruciate ligament ruptures can cause long-term deficits. To assist in identifying and treating deficiencies, 3D-motion analysis is used for objectivizing data. Conventional statistics are commonly employed to analyze kinematics, reducing continuous data series to discrete variables. Conversely, functional data analysis considers the entire data series. Here, we employ functional data analysis to examine and compare the entire time-domain of knee-kinematic curves from one-leg hops between and within three groups. All subjects (n=95) were part of a long-term follow-up study involving anterior cruciate ligament ruptures treated ~20 years ago conservatively with physiotherapy only or with reconstructive surgery and physiotherapy, and matched knee-healthy controls. Between-group differences (injured leg, treated groups; non-dominant leg, controls) were identified during the take-off and landing phases, and in the sagittal (flexion/extension) rather than coronal (abduction/adduction) and transverse (internal/external) planes. Overall, surgical and control groups demonstrated comparable knee-kinematic curves. However, compared to controls, the physiotherapy-only group exhibited less flexion during the take-off (0-55% of the normalized phase) and landing (44-73%) phase. Between-leg differences were absent in controls and the surgically treated group, but observed during the flight (4-22%, injured leg>flexion) and the landing (57-85%, injured legFunctional data analysis identified specific functional knee-joint deviations from controls persisting 20 years post anterior cruciate ligament rupture, especially when treated conservatively. This approach is suggested as a means for comprehensively analyzing complex movements, adding to previous analyses. Copyright © 2015 Elsevier Ltd. All rights reserved.

  13. Latest trends and directions of development of crowdfunding

    Directory of Open Access Journals (Sweden)

    Joanna Pieniążek

    2014-09-01

    Full Text Available The article discusses the latest trends and directions of development of crowdfunding on selected examples of English-language websites.The scope of work includes topics such as aggregates of crowdfunding sites, local investing, franchise, pre-sales platforms, open source sites and leveraging the competitive advantages of e-commerce platforms which offer product crowdfunding. This article aims to discuss the latest trends and directions of crowdfunding, assess their usefulness and the chances of popularising the ideas presented. The article provides an overview of the literature on the subject and an analysis of the selected sites, comparison sites and crowdfunding search engines.

  14. Foundations and latest advances in replica exchange transition interface sampling

    NARCIS (Netherlands)

    Cabriolu, R.; Refsnes, K.M.S; Bolhuis, P.G.; van Erp, T.S.

    2017-01-01

    Nearly 20 years ago, transition path sampling (TPS) emerged as an alternative method to free energy based approaches for the study of rare events such as nucleation, protein folding, chemical reactions, and phase transitions. TPS effectively performs Monte Carlo simulations with relatively short

  15. The Cardiff dental study: a 20-year critical evaluation of the psychological health gain from orthodontic treatment.

    Science.gov (United States)

    Kenealy, Pamela M; Kingdon, Anne; Richmond, Stephen; Shaw, William C

    2007-02-01

    Despite the widespread belief that orthodontics improves psychological well-being and self-esteem, there is little objective evidence to support this (Kenealy et al., 1989a; Shaw, O'Brien, Richmond, & Brook, 1991). A 20 year follow-up study compared the dental and psychosocial status of individuals who received, or did not receive, orthodontics as teenagers. A prospective longitudinal cohort design with four studies of the effect of orthodontic treatment. Secondary analysis of outcome data incorporated orthodontic need at baseline and treatment received in a 2 x 2 factorial design. A multidisciplinary research programme studied a cohort of 1,018, 11-12 year old participants in 1981. Extensive assessment of dental health and psychosocial well-being was conducted; facial and dental photographs and plaster casts of dentition were obtained and rated for attractiveness and pre-treatment need. No recommendations about orthodontic treatment were made, and an observational approach was adopted. At the third follow-up 337 (30-31 year olds) were re-examined in 2001. Participants with a prior need for orthodontic treatment as children who obtained treatment demonstrated better tooth alignment and satisfaction. However when self-esteem at baseline was controlled for, orthodontics had little positive impact on psychological health and quality of life in adulthood. Lack of orthodontic treatment where there was a prior need did not lead to psychological difficulties in later life. Dental status alone was a weak predictor of self-esteem at outcome explaining 8% of the variance. Self-esteem in adulthood was more strongly predicted (65% of the variance) by psychological variables at outcome: perception of quality of life, life satisfaction, self-efficacy, depression, social anxiety, emotional health, and by self-perception of attractiveness. Longitudinal analysis revealed that the observed effect of orthodontic treatment on self esteem at outcome was accounted for by self esteem at

  16. Mortality from road traffic accidents in a rapidly urbanizing Chinese city: A 20-year analysis in Shenzhen, 1994-2013.

    Science.gov (United States)

    Xie, Shao-Hua; Wu, Yong-Sheng; Liu, Xiao-Jian; Fu, Ying-Bin; Li, Shan-Shan; Ma, Han-Wu; Zou, Fei; Cheng, Jin-Quan

    2016-01-01

    This study aimed to describe the trends of motorization and mortality rates from road traffic accidents and examine their associations in a rapidly urbanizing city in China, Shenzhen. Using data from the Shenzhen Deaths Registry between 1994 and 2013, we calculated the annual mortality rates of road traffic accidents, in addition to the age- and sex-specific mortality rates and their annual percentage changes (APCs) for the period of 2000-2013. We also examined the associations between mortality rate of road traffic accidents and traffic growth with Spearman's rank correlation analysis and a log-linear model derived from Smeed's law. A total of 20,196 deaths due to road traffic accidents, including 14,391 (71.3%) male deaths and 5,805 (28.7%) female deaths, were recorded in Shenzhen from 1994 to 2013. The annual mortality rates in terms of deaths per population and deaths per vehicle changed in similar patterns, demonstrating an increase since 1994 and peaking in 1997, followed by a steady decrease thereafter. The decrease in mortality was faster in individuals aged 20 year or older compared to those younger than 20 years. The mortality rates in term of deaths per population were positively correlated with the total number of vehicles per kilometer of road but negatively correlated with the motorization rate in term of vehicles per population. The estimated model for deaths due to road traffic accidents in relation to the total population and the number of registered vehicles was ln (deaths/10,000 vehicles) = -1.902 × ln (vehicles/population) - 1.961. The coefficient was statistically significant (P traffic accidents in a rapidly urbanizing Chinese city based observations in the 20-year period from 1994 to 2013. The decreased mortality rate may be explained by the expansion of road network construction, improved road safety regulations and management, as well as more accessible ambulance services in recent years. Nevertheless, road traffic accidents remain a

  17. Changes in social interaction over 20 years and the effects of community resources use among community-dwelling elderly persons.

    Science.gov (United States)

    Watanabe, Kumi; Tanaka, Emiko; Wu, Bailiang; Kobayashi, Zyunko; Mochizuki, Yukiko; Kim, Yeon; Watanabe, Taeko; Okumura, Rika; Ito, Sumio; Anme, Tokie

    2017-01-01

    Objectives Recently, social isolation has been reported to be a critical problem among Japanese elderly persons. However, few studies have compared social interaction in the past and the present or investigated its predictive factors. This study aimed to clarify the transitional changes in social interaction over 20 years and explore the factors related to social interaction focusing on the use of community resources.Methods The participants were community-dwelling elderly persons aged 65 years and over. A survey was conducted 8 times from 1994 to 2014 in the suburban area of Tobishima, Japan. The Index of Social Interaction Scale was used and each subscale and the total score were calculated. Subsequently, the 2014 scores were compared with the 1994 scores using the Wilcoxon rank sum test. Logistic regression analysis was conducted to clarify the factors related to social interaction, focusing on the association between the use of community resources (local elderly management center, health care center, health promotion facility, library) in 2011 and social interaction 3 years later. Age, gender, disease, and mobility were also entered into the model as control variables.Results Comparing social interaction in 1994 and 2014, total scores were found to have significantly increased in all age groups. Independence scores significantly increased in the overall group and in females aged 75-84. Curiosity scores also increased in both males and females. These results show that social interaction has increased over 2 decades. In addition, the use of local elderly management and health care centers, and health promotion facilities was associated with total social interaction scores 3 years later.Conclusion The current study clarified changes in social interaction, both comprehensively and for each of its aspects, among community-dwelling elderly adults. Increasing social isolation has been reported in recent years; however, the current study showed that social

  18. Mesenchymal chondrosarcoma of bone and soft tissue: a systematic review of 107 patients in the past 20 years.

    Directory of Open Access Journals (Sweden)

    Jie Xu

    Full Text Available Mesenchymal chondrosarcoma(MCS is a rare high-grade variant of chondrosarcoma. Consensus has not been reached on its optimal management. Resection with wide margins is usually recommended, but the effect of margins has been demonstrated by little positive evidence. Moreover, the effectiveness of adjuvant chemo- and/or radiotherapy remains controversial.To describe the clinical characteristics and outcomes of MCS of bone and soft tissue, to assess the efficacies of surgery, chemotherapy and radiation, and finally to deliver a more appropriate therapy.We reviewed EMBASE-, MEDLINE-, Cochrane-, Ovid- and PubMed-based to find out all cases of MCS of bone and soft tissue described between April 1994 and April 2014. Description of treatment and regular follow-up was required for each study. Language was restricted to English and Chinese. Issues of age, gender, location, metastasis, and treatment were all evaluated for each case. Kaplan-Meier Method and Cox Proportional Hazard Regression Model were used in the survival analysis.From the 630 identified publications, 18 meeting the inclusion criteria were selected, involving a total of 107 patients. Based on these data, the 5-, 10-and 20-year overall survival are 55.0%, 43.5% and 15.7% respectively. The 5-, 10-, 20- year event-free survival rates are 45.0%, 27.2% and 8.1%, respectively. Treatment without surgery is associated with poorer overall survival and event-free survival. Negative surgical margins could significantly bring down the local-recurrence rate and are associated with a higher event-free survival rate. Chemotherapy regime based on anthracyclines does not benefit the overall survival. The addition of radiation therapy is not significantly associated with the overall or event-free survival. However, we recommend radiation as the salvage therapy for patients with positive margin so as to achieve better local control.This review shows that surgery is essential in the management of MCS of bone

  19. Shifts in soil fungal communities in Tuber melanosporum plantations over a 20-year transition from agriculture fields to oak woodlands

    Energy Technology Data Exchange (ETDEWEB)

    Bing, L.; Fischer, C.R.; Bonet, J.A.; Castaño, C.; Colinas, C.

    2016-07-01

    Aim of study: To explore the diversity of soil fungi found in black truffle (Tuber melanosporum) plantations following the introduction of the mycorrhizal-colonized host tree, (Quercus ilex), through the development of the brûlé and production of mature sporocarps. Area of study: This research was carried out province of Teruel, Aragon (central eastern Spain). Material and Methods: Soil samples from 6 plantations were collected beneath Q. ilex trees inoculated with T. melanosporum, of 3, 5, 7, 10, 14 and 20 years after out planting in truffle plantations. Soil DNA was extracted, PCR-amplified and sequenced to compare soil fungi present at different ages. Main results: As tree age increased, we observed an increased frequency of T. melanosporum (from 8% to 71% of sequenced colonies) and concomitant decrease in the combined frequency of Fusarium spp. and Phoma spp. (from 64% to 3%). Research highlights: There are important shifts in species richness and in functional groups in the soil fungal communities in maturing black truffle-oak woodland plantations. The observed inverse relationship between the frequency of soil endophytic and/or pathogenic fungi and that of the mycorrhizal mutualist T. melanosporum provides support to continue a deeper analysis of shifts in fungal communities and functional groups where there is a transition from agriculture fields to woodlands. (Author)

  20. Sea-level trend in the South China Sea observed from 20 years of along-track satellite altimetric data

    DEFF Research Database (Denmark)

    Cheng, Yongcun; Xu, Qing; Andersen, Ole Baltazar

    2014-01-01

    The sea-level trend in the South China Sea (SCS) is investigated based on 20 years of along-track data from TOPEX and Jason-1/2 satellite altimetry. The average sea-level rise over all the regions in the study area is observed to have a rate of 5.1 ± 0.8 mm year-1 for the period from 1993 to 2012....... The steric sea level contributes 45% to the observed sea-level trend. These results are consistent with previous studies. In addition, the results demonstrate that the maximum sea-level rise rate of 8.4 mm year-1 is occurring off the east coast of Vietnam and eastern part of SCS. During 2010-2011, the La...... Niña event was highly correlated with the dramatic sea-level rise in the SCS; La Niña events were also associated with the maximum rate of sea rise off the east coast of Vietnam, which occurred during 1993 and 2012. We also evaluated the trends in the geophysical (e.g. dynamical atmospheric correction...

  1. NIR Color vs Launch Date: A 20-Year Analysis of Space Weathering Effects on the Boeing 376 Spacecraft

    Science.gov (United States)

    Frith, James; Anz-Meador, Philip; Lederer, Sue; Cowardin, Heather; Buckalew, Brent

    2015-01-01

    The Boeing HS-376 spin stabilized spacecraft was a popular design that was launched continuously into geosynchronous orbit starting in 1980 with the last launch occurring in 2002. Over 50 of the HS-376 buses were produced to fulfill a variety of different communication missions for countries all over the world. The design of the bus is easily approximated as a telescoping cylinder that is covered with solar cells and an Earth facing antenna that is despun at the top of the cylinder. The similarity in design and the number of spacecraft launched over a long period of time make the HS-376 a prime target for studying the effects of solar weathering on solar panels as a function of time. A selection of primarily non-operational HS-376 spacecraft launched over a 20 year time period were observed using the United Kingdom Infrared Telescope on Mauna Kea and multi-band near-infrared photometry produced. Each spacecraft was observed for an entire night cycling through ZYJHK filters and time-varying colors produced to compare near-infrared color as a function of launch date. The resulting analysis shown here may help in the future to set launch date constraints on the parent object of unidentified debris objects or other unknown spacecraft.

  2. An updated radiation protection program prospectus based on 20 years of data describing program drivers and activities.

    Science.gov (United States)

    Emery, Robert J; Gutierrez, Janet M

    2014-08-01

    In 1992, the University of Texas Health Science Center at Houston (UTHSCH) Radiation Safety Program began assembling data on a monthly basis that described various program drivers and associated activities. At the end of calendar year 2002, a decade of data had been collected, so the information was summarized into a novel program prospectus, displaying various program indicator parameters in a format similar to that used in a commercial enterprise prospectus provided to potential investors. The consistent formatting of the data afforded a succinct and easily digestible snapshot of program activities and trends. Feedback from various program stakeholders, even those unfamiliar with radiation safety matters, was overwhelmingly positive. By the end of 2012, a total of 20 years of data had been collected, so an updated and slightly modified prospectus was created. The summary document has helped to describe the drivers of the program, revealed some interesting trends, and has aided in maintaining program support even in challenging economic times. The data summary has also proved to be useful in making future projections regarding program needs.

  3. Changes in epidemiological patterns of HCV infection and their impact on liver disease over the last 20 years in Greece.

    Science.gov (United States)

    Savvas, S P; Koskinas, J; Sinani, C; Hadziyannis, A; Spanou, F; Hadziyannis, S J

    2005-09-01

    The aim of this study was to investigate the relative frequency of hepatitis C virus (HCV) genotypes in Greek patients with chronic infection as well as possible secular changes in their distribution in relation to modes of transmission, age and time at acquisition of the infection and other variables. We evaluated 434 unselected patients, 241 males and 193 females with a median age of 46.2 years (18-75), with chronic HCV infection presenting during the period 1996-2000. HCV infection was confirmed by the detection of HCV-RNA by polymerase chain reaction (PCR), while HCV genotyping was performed by the Inno-LiPA assay. Liver biopsies were evaluated according to Ishak's scoring system. Of 434 patients, 167 had a history of blood transfusion [post-transfusion hepatitis (PTH)], 80 were i.v. drug users and in 187 the route of infection remained unknown. The overall distribution of HCV genotypes 1, 2, 3 and 4 was 47, 8.3, 27 and 15.2%, respectively. Genotype 3 was common in younger adults and i.v. drug users, whereas genotype 1 predominated in older people and PTH patients (P duration of infection (P = 0.013). Our study revealed a change of HCV genotype distribution in the last 20 years among Greek patients with chronic HCV infection as a result of epidemiological changes in HCV transmission. The presence of cirrhosis was associated only with the duration of infection. These observations have impact both on prevention and treatment.

  4. Natural History of Parkinson's Disease in the Province of Segovia: Disability in a 20 Years Longitudinal Study.

    Science.gov (United States)

    Duarte, Jacinto; García Olmos, Luis Miguel; Mendoza, Amelia; Martínez Pueyo, Ángel; Clavería, Luis Erik

    2015-01-01

    Parkinson's disease mainly affects the elderly population causing a progressive functional disability with motor, psychic, and cognitive deterioration. This study was carried out to evaluate disability caused by Parkinson's disease by analyzing the median time to reach Hoehn and Yahr stage III and to investigate predictor variables based on a 20-year longitudinal follow-up study. We examined 273 patients with Parkinson's disease recruited between 1978 and 1998. We performed a survival analysis using the Kaplan-Meier method to determine the time to disability and we used a Cox regression model to adjust prognosis factors. The median time to reach Hoehn and Yahr stage III was 7.73 years (95% CI: 5.95-8.05). Independent predictors of disability were: age at onset, the hazard ratio (HR) = 1.10, 95% CI: 1.08-1.12; UPDRS II (activities of daily living) HR = 1.08, 95% CI: 1.03-1.14; and akinesia and rigidity at onset HR = 1.55, 95% CI: 1.07-2.24. Patients with Parkinson's disease evolve gradually toward disability, and prognostic factors of this evolution were identified. © 2015 S. Karger AG, Basel.

  5. Evolution and perspectives in waste incineration emissions and flue gas cleaning systems in the last 20 years

    International Nuclear Information System (INIS)

    Giugliano, M.; Cernuschi, S.; Grosso, M.

    2006-01-01

    The evolution of the technology of waste combustion, energy recovery and flue gas treatment allows to redefine the role of the incineration plant as a basic component of integrated waste management systems. Starting with an overview of the evaluation of emission limits and of the new Best Available Techniques (BAT) approach, strongly recommended by the European Union, the paper reports an overview of the stack emission concentrations measured in recent plants in Italy compared to older ones, with special attention to the dioxin issue. Concerning this topic, it is demonstrated that BAT-equipped plants can act as actual dioxin destroyer rather than producers, even when all the fluxes released in the environment (gaseous, solid and liquid residues) are taken into account. The second part of the paper deals with the evolution of the flue gas control technologies of the last 20 years, pointing out the major trends and the future perspectives for further increases of the removal monitoring of conventional and trace pollutants are briefly described [it

  6. Public awareness of testis cancer and the prevalence of testicular self-examination-changing patterns over 20 years.

    LENUS (Irish Health Repository)

    Casey, Rowan G

    2012-02-01

    OBJECTIVES: Delay in treatment of testis cancer (TC) has a proven negative impact on disease stage, treatment outcome, and mortality. Poor public awareness of the disease and lack of testis self-examination (TSE) may account for late presentation. The aim of this study was to examine the knowledge of TC and performance of TSE in a group of men over 2 time periods 20 years apart. METHODS: In the current study, 677 men from a banking institution were surveyed on their knowledge of TC and their performance of TSE. Comparisons were made from the current data and those from the original study in 1986. RESULTS: This study demonstrates an increase in public awareness and modest concomitant increase in TSE since first studied in this country in 1986. There was no difference in knowledge across age groups in this study. Furthermore, men who demonstrate a superior degree of knowledge were more likely to perform TSE. Limitations included possible selection bias in the 2 studies conducted in a banking institution. CONCLUSIONS: Increased testicular cancer knowledge combined with TSE may have a role in improving detection of significant testicular pathology.

  7. Secondary Alveolar Bone Grafting in Patients Born With Unilateral Cleft Lip and Palate: A 20-Year Follow-up.

    Science.gov (United States)

    Jabbari, Fatemeh; Wiklander, Laila; Reiser, Erika; Thor, Andreas; Hakelius, Malin; Nowinski, Daniel

    2018-02-01

    To identify factors of oral health important for the final outcome, after secondary alveolar bone grafting in patients born with unilateral cleft lip and palate and compare occlusal radiographs with cone beam computed tomography (CBCT) in assessment of alveolar bone height. Observational follow-up study. Cleft Lip and Palate Team, Craniofacial Center, Uppsala University Hospital, Sweden. 40 nonsyndromic, Caucasian patients with unilateral complete cleft lip and palate. Clinical examination, CBCT, and occlusal radiographs. Alveolar bone height was evaluated according to Bergland index at a 20-year follow-up. The alveolar bone height in the cleft area was significantly reduced compared to a previously reported 10-year follow-up in the same cohort by total ( P = .045) and by subgroup with dental restoration ( P = .0078). This was positively correlated with the gingival bleeding index (GBI) ( r = 0.51, P = .0008) and presence of dental restorations in the cleft area ( r = 0.45, P = .0170). There was no difference in the Bergland index generated from scoring the alveolar bone height on occlusal radiographs as with the equivalent index on CBCT. Patients rehabilitated with complex dental restoration seems to be at higher risk for progression of bone loss in the cleft area. Supportive periodontal therapy should be implemented after complex dental restorations in cleft patients. Conventional occlusal radiographs provide an adequate image for evaluating postoperative bone height in clinical follow-up.

  8. Observation of galactic cosmic ray spallation events from the SoHO mission 20-Year operation of LASCO

    Science.gov (United States)

    Koutchmy, S.; Tavabi, E.; Urtado, O.

    2018-05-01

    A shower of secondary Cosmic Ray (CR) particles is produced at high altitudes in the Earth's atmosphere, so the primordial Galactic Cosmic Rays (GCRs) are never directly measured outside the Earth magnetosphere and atmosphere. They approach the Earth and other planets in the complex pattern of rigidity's dependence, generally excluded by the magnetosphere. GCRs revealed by images of single nuclear reactions also called spallation events are described here. Such an event was seen on Nov. 29, 2015 using a unique LASCO C3 space coronagraph routine image taken during the Solar and Heliospheric Observatory (SoHO) mission observing uninterruptedly at the Lagrangian L1 point. The spallation signature of a GCR identified well outside the Earth's magnetosphere is obtained for the 1st time. The resulting image includes different diverging linear "tracks" of varying intensity, leading to a single pixel; this frame identifies the site on the silicon CCD chip of the coronagraph camera. There was no solar flare reported at that time, nor Coronal Mass Ejection (CME) and no evidence of optical debris around the spacecraft. More examples of smaller CR events have been discovered through the 20 years of continuous observations from SoHO. This is the first spallation event from a CR, recorded outside the Earth's magnetosphere. We evaluate the probable energy of these events suggesting a plausible galactic source.

  9. Costs resulting from premature mortality due to cardiovascular causes: A 20-year follow-up of the DRECE study.

    Science.gov (United States)

    Gómez-de la Cámara, A; Pinilla-Domínguez, P; Vázquez-Fernández Del Pozo, S; García-Pérez, L; Rubio-Herrera, M A; Gómez-Gerique, J A; Gutiérrez-Fuentes, J A; Rivero-Cuadrado, A; Serrano-Aguilar, P

    2014-10-01

    Cardiovascular diseases are still the leading cause of death in Spain. The DRECE study (Diet and Cardiovascular Disease Risk in Spain), based on a representative cohort of the Spanish general population, analyzed nutritional habits and lifestyle and their association with morbidity and mortality patterns. We estimated the impact, in terms of loss of productivity, of premature mortality attributed to cardiovascular diseases. The loss of productivity attributed to premature mortality was calculated from 1991, based on the potential years of life lost and the potential years of working life lost. During the 20-year follow-up of a cohort of 4779 patients, 225 of these patients died (men, 152). Sixteen percent of the deaths were attributed to cardiovascular disease. The costs due to lost productivity by premature mortality exceeded 29 million euros. Of these, 4 million euros (14% of the total cost) were due to cardiovascular causes. Premature cardiovascular mortality in the DRECE cohort represented a significant social cost due to lost productivity. Copyright © 2014 Elsevier España, S.L.U. All rights reserved.

  10. Assessments of sheath strain and fission gas release data from 20 years of power reactor fuel irradiations

    International Nuclear Information System (INIS)

    Purdy, P.L.; Manzer, A.M.; Hu, R.H.; Gibb, R.A.; Kohn, E.

    1997-01-01

    Over the past 20 years, many fuel elements or bundles discharged from Canadian CANDU power reactors have been examined in the AECL hot cells. The post-irradiation examination (PIE) database covers a wide range of operating conditions, from which fuel performance characteristics can be assessed. In the present analysis, a PIE database was compiled representing elements from a total of 129 fuel bundles, of which 26% (34 bundles) were confirmed to have one or more defective elements. This comprehensive database was assessed in terms of measured sheath strain and fission gas release (FGR) for intact elements, in an attempt to identify any changes in these parameters over the history of CANDU reactor operation. Results from this assessment indicate that, for the data that are typical of normal CANDU operating conditions, tensile sheath strain and FGR have remained within 0.5% and 8%, respectively. Those data beyond these ranges are from fuel operated under abnormal conditions, not representative of normal operation, and thus do not indicate a trend toward unexpected fuel behaviour. The distributions of the PIE measurements indicate that maximum expected sheath strains and FGR for normally operated fuel are 0.7% and 13%, respectively. (author)

  11. [A 20-year follow-up study of a sample of 50 pairs of twins with neurotic-psychosomatic disorders].

    Science.gov (United States)

    Muhs, A; Schepank, H; Manz, R

    1990-01-01

    As part of a research project, examination was made of a sample of 50 pairs of twins (21 pairs of identical twins, 16 pairs of non-identical twins of the same sex, and 13 pairs of male-female twins [n = 100 test persons]) between 1963 and 1969 and again recently after a period of 20 years. The index twins were drawn from among the patients who made use of the services of an out-patient psychotherapeutic clinic, and they were determined to be either psychoneurotic, character neurotic, or psychosomatically ill. The question examined was again one of nature vs. nurture. Identical twins showed a significantly higher similarity with regard to the seriousness of their neuroses and the manifestation of neurotic symptoms than did non-identical twins. Noticeable similarities existed in cases of depressive disturbances, disturbances of oral and aggressive behavior, and disturbances of interpersonal contact. With regard to the influence of variables in the environment, we examined the effect of factors in early childhood on neurotic development. Lack of a reference person, a negative attitude on the part of parents toward the child, etc., frustration within and outside the family have an effect on the manifestation of neuroses and on the course of their development. The influence of early childhood factors on the degree of neurotic disorder is still to be noted in the current point prevalence.

  12. Lower limb lengthening in patients with disproportionate short stature with achondroplasia: a systematic review of the last 20 years.

    Science.gov (United States)

    Schiedel, Frank; Rödl, Robert

    2012-01-01

    Parents of children suffering from disproportionate short stature due to achondroplasia may wish to have surgical leg lengthening carried out for the child. The aim is not to increase height, but rather to achieve physiological proportions in the body. In a systematic review of the literature on the topic dating from the last 20 years, the surgical approaches used for this purpose were analyzed in accordance with the Preferred reporting items for systematic reviews and meta-analyses (PRISMA) criteria. Twelve studies show that to date, involvement of the child in decision-making at the start of treatment has been expected and that it is recommended from the age of 12. In highly heterogeneous patient groups, with varying factors involved and different techniques being used, lengthening (often by more than 10 cm) is described. High complication rates are reported, with many setbacks often requiring repeat surgery. Using PALEY'S multiplier method, the expected standing height, sitting height, and leg length can be predicted and an individualized treatment approach can be planned and operative procedures could be started in early childhood as PERETTI suggests. As the patients are unable to be involved in decision-making as young children, these data may provide a basis for offering differentiated advice to parents, who usually consult a pediatric orthopedist at a very early stage in the child's life.

  13. Time trends in 20 years of medication use in older adults: Findings from three elderly cohorts in Stockholm, Sweden.

    Science.gov (United States)

    Craftman, Åsa Gransjön; Johnell, Kristina; Fastbom, Johan; Westerbotn, Margareta; von Strauss, Eva

    2016-01-01

    New drugs and expanded drug indications are constantly being introduced. Welfare states strive to provide equity in drug treatment for all of its citizens and todaýs healthcare systems spend financial resources on drugs for the elderly in a higher rate than for any other age group. Drug utilization in elderly persons has an impact in health and wellbeing in older people. It was to describe the changes in medication use including people aged 78 years and over regardless of residence and other characteristics over 20 years. The study population consisted of 4304 participants in three population-based cross-sectional surveys conducted in the Kungsholmen area of central Stockholm, Sweden. The participant's current drug utilization was reviewed by physicians following standardized protocols. Data were statistical analyzed. Logistic regression models was used to estimate odds ratios and 95% confidence intervals for use of analgesics and psychotropic drugs in the cohorts of 2001 and 2007, controlling for age, gender, education and cognition. Results shows that the prevalence of medication use and polypharmacy in older adults has increased dramatically the late 1980s to the 2000s in central Stockholm, Sweden. In particular, the use of analgesics increased significantly, while some drug groups decreased, i.e., antipsychotics. Women used more medication than men in all three cohorts. Older adults living in service buildings used the largest amount of drugs in 1987, whereas those living in institutions were the most frequent users in 2001 and 2007. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  14. Pediatric Burns from Glass-Fronted Fireplaces in Canada: A Growing Issue Over the Past 20 Years.

    Science.gov (United States)

    Toor, Jay; Crain, Jennifer; Kelly, Charis; Verchere, Cindy; Fish, Joel

    2016-01-01

    There is an alarming lack of public awareness surrounding the safety of glass-fronted fireplaces. This has resulted in an active campaign from the American Burn Association Prevention Committee. One issue encountered while advocating for prevention among manufacturers is the lack of corroborating and accurate data. The purpose of this study was to examine the annual trends and epidemiology of glass-fronted fireplace-related burn injuries to children less than 15 years old, who presented to Canadian emergency departments between 1990 and 2010. Records of pediatric burn injuries related to glass-fronted fireplaces were extracted from the Canadian Hospitals Injury Reporting and Prevention Program database for the study period (1990-2010). Cases were analyzed in terms of anatomic area affected, demographics, seasonality, safety device use, and injury severity. A total of 616 cases of burns from glass-fronted fireplaces were identified. The incidence increased at an average of 2.7 cases per year. This is a greater than 20-fold increase over 20 years. Seventy-five percentage of the cases occurred in children less than 2 years, and 95% occurred in children less than 5 years. The study demonstrated a growing risk from glass-fronted fireplace burns, likely due to the increasing popularity of household gas fireplace units. These units are a particular risk to children less than 2 years, attributable to their developing mobility and reduced reaction time. This is a preventable injury that should be addressed through changes to legislation and manufacturing.

  15. Shifts in soil fungal communities in Tuber melanosporum plantations over a 20-year transition from agriculture fields to oak woodlands

    Directory of Open Access Journals (Sweden)

    Liu Bing

    2016-04-01

    Full Text Available Aim of study: To explore the diversity of soil fungi found in black truffle (Tuber melanosporum plantations following the introduction of the mycorrhizal-colonized host tree, (Quercus ilex, through the development of the brûlé and production of mature sporocarps.Area of study: This research was carried out province of Teruel, Aragon (central eastern Spain.Material and Methods: Soil samples from 6 plantations were collected beneath Q. ilex trees inoculated with T. melanosporum, of 3, 5, 7, 10, 14 and 20 years after out planting in truffle plantations. Soil DNA was extracted, PCR-amplified and sequenced to compare soil fungi present at different ages.Main results: As tree age increased, we observed an increased frequency of T. melanosporum (from 8% to 71% of sequenced colonies and concomitant decrease in the combined frequency of Fusarium spp. and Phoma spp. (from 64% to 3%.Research highlights: There are important shifts in species richness and in functional groups in the soil fungal communities in maturing black truffle-oak woodland plantations. The observed inverse relationship between the frequency of soil endophytic and/or pathogenic fungi and that of the mycorrhizal mutualist T. melanosporum provides support to continue a deeper analysis of shifts in fungal communities and functional groups where there is a transition from agriculture fields to woodlands.Abbreviations used: Ectomycorrhiza (ECM fungus; Vesicular arbuscular mycorrhiza (VAM; Operational taxonomic unit (OTU.

  16. Testing aggregation hypotheses among Neotropical trees and shrubs: results from a 50-ha plot over 20 years of sampling.

    Science.gov (United States)

    Myster, Randall W; Malahy, Michael P

    2012-09-01

    Spatial patterns of tropical trees and shrubs are important to understanding their interaction and the resultant structure of tropical rainforests. To assess this issue, we took advantage of previously collected data, on Neotropical tree and shrub stem identified to species and mapped for spatial coordinates in a 50ha plot, with a frequency of every five years and over a 20 year period. These stems data were first placed into four groups, regardless of species, depending on their location in the vertical strata of the rainforest (shrubs, understory trees, mid-sized trees, tall trees) and then used to generate aggregation patterns for each sampling year. We found shrubs and understory trees clumped at small spatial scales of a few meters for several of the years sampled. Alternatively, mid-sized trees and tall trees did not clump, nor did they show uniform (regular) patterns, during any sampling period. In general (1) groups found higher in the canopy did not show aggregation on the ground and (2) the spatial patterns of all four groups showed similarity among different sampling years, thereby supporting a "shifting mosaic" view of plant communities over large areas. Spatial analysis, such as this one, are critical to understanding and predicting tree spaces, tree-tree replacements and the Neotropical forest patterns, such as biodiversity and those needed for sustainability efforts, they produce.

  17. Assessment of the Impact of GNSS Processing Strategies on the Long-Term Parameters of 20 Years IWV Time Series

    Directory of Open Access Journals (Sweden)

    Zofia Baldysz

    2018-03-01

    Full Text Available Advanced processing of collected global navigation satellite systems (GNSS observations allows for the estimation of zenith tropospheric delay (ZTD, which in turn can be converted to the integrated water vapour (IWV. The proper estimation of GNSS IWV can be affected by the adopted GNSS processing strategy. To verify which of its elements cause deterioration and which improve the estimated GNSS IWV, we conducted eight reprocessings of 20 years of GPS observations (01.1996–12.2015. In each of them, we applied a different mapping function, the zenith hydrostatic delay (ZHD a priori value, the cut-off angle, software, and the positioning method. Obtained in such a way, the ZTD time series were converted to the IWV using the meteorological parameters sourced from the ERA-Interim. Then, based on them, the long-term parameters were estimated and compared to those obtained from the IWV derived from the radio sounding (RS observations. In this paper, we analyzed long-term parameters such as IWV mean values, linear trends, and amplitudes of annual and semiannual oscillations. A comparative analysis showed, inter alia, that in terms of the investigation of the IWV linear trend the precise point positioning (PPP method is characterized by higher accuracy than the differential one. It was also found that using the GPT2 model and the higher elevation mask brings benefits to the GNSS IWV linear trend estimation.

  18. The Impact of Risk Factors of Chronic Pancreatitis on Secretin Pancreatic Function Testing: Results of a 20-Year Study.

    Science.gov (United States)

    Kothari, Darshan; Ketwaroo, Gyanprakash; Freedman, Steven D; Sheth, Sunil G

    2017-08-01

    The aim of this study was to determine the effect of established risk factors on the outcome of secretin pancreatic function testing (sPFT) in patients undergoing work-up for suspected chronic pancreatitis. We completed a retrospective review of patients who underwent sPFT for suspected chronic pancreatitis over 20 years. We compared peak bicarbonate concentrations between groups and completed univariate and multivariate analyses to determine associations between risk factors and positive sPFT results (peak bicarbonate pancreatitis (RAP) and with local complications from acute pancreatitis (AP) (P ≤ 0.05). The bicarbonate concentration in patients with and without other risk factors such as tobacco use, alcohol use, and family history of pancreatitis was not significantly different. Female sex, a history of AP, and a history of RAP were associated with positive sPFT results on univariate analysis (P ≤ 0.05). On multivariate analysis, sex and RAP remained significant. Our study demonstrates that female sex, history of AP and RAP, and AP with local complications are associated with positive sPFT results or lower peak bicarbonate concentration. However, other risk factors do not impact the results of sPFT.

  19. Review and reflection of research on the knowledge structure of physical education teachers in the past 20 years

    Directory of Open Access Journals (Sweden)

    LU Bochun

    2013-08-01

    Full Text Available From the view of knowledge,methodology and other perspectives of regression and reflection on the knowledge structure of the PE teachers of the status quo in the past 20 years,it is considered that the base of the existing knowledge of research is primarily on the knowledge view of objectivism,the perspective of research is restricted.For many years research category of the knowledge structure of PE teachers was consistently confined to discipline knowledge + educational knowledge + culture knowledge.Research Methodology and methods are mainly confined to Speculative theory research guided by rational debate methodology and questionnaire survey research guided by positivist methodology.Due to the impact of the knowledge view of objectivism,rational debate focuses on the objectivity theory knowledge ought status in knowledge structure of PE teachers.Questionnaire survey research is mainly based on attitude survey research,reflecting the ideal state of knowledge structure of physical education teachers.Suggestion: update knowledge,enrich methodological the guidance,pay more attention to the actual condition of knowledge structure of physical education teachers,reveal physical education teachers in the context of the formation,development,and application patterns of their knowledge structure in sports teaching situation,etc.

  20. Physical activity patterns and risk of depression in young adulthood: a 20-year cohort study since childhood.

    Science.gov (United States)

    McKercher, Charlotte; Sanderson, Kristy; Schmidt, Michael D; Otahal, Petr; Patton, George C; Dwyer, Terence; Venn, Alison J

    2014-11-01

    Little is known about how physical activity patterns during childhood and adolescence are associated with risk of subsequent depression. We examined prospective and retrospective associations between leisure physical activity patterns from childhood to adulthood and risk of clinical depression in young adulthood. Participants (759 males, 871 females) in a national survey, aged 9-15 years, were re-interviewed approximately 20 years later. Leisure physical activity was self-reported at baseline (1985) and follow-up (2004-2006). To bridge the interval between the two time-points, historical leisure activity from age 15 years to adulthood was self-reported retrospectively at follow-up. Physical activity was categorized into groups that, from a public health perspective, compared patterns that were least beneficial (persistently inactive) with those increasingly beneficial (decreasing, increasing and persistently active). Depression (major depressive or dysthymic disorder) was assessed using the Composite International Diagnostic Interview. Compared with those persistently inactive, males who were increasingly and persistently active had a 69 and 65 % reduced risk of depression in adulthood, respectively (all p active had a 51 % reduced risk of depression in adulthood (p = 0.01). Similar but non-significant trends were observed for leisure physical activity in females and historical leisure activity in males. Results excluded those with childhood onset of depression and were adjusted for various sociodemographic and health covariates. Findings from both prospective and retrospective analyses indicate a beneficial effect of habitual discretionary physical activity since childhood on risk of depression in young adulthood.

  1. Restoration of Eutrophic Lakes with Fluctuating Water Levels: A 20-Year Monitoring Study of Two Inter-Connected Lakes

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    Meryem Beklioğlu

    2017-02-01

    Full Text Available Eutrophication continues to be the most important problem preventing a favorable environmental state and detrimentally impacting the ecosystem services of lakes. The current study describes the results of analyses of 20 year monitoring data from two interconnected Anatolian lakes, Lakes Mogan and Eymir, receiving sewage effluents and undergoing restoration. The first step of restoration in both lakes was sewage effluent diversion. Additionally, in hypertrophic Lake Eymir, biomanipulation was conducted, involving removal of benthi-planktivorous fish and prohibition of pike fishing. The monitoring period included high (H and low (L water levels (WL enabling elucidation of the effects of hydrological changes on lake restoration. In shallower Lake Mogan, macrophyte abundance increased after the sewage effluent diversion in periods with low water levels even at turbid water. In comparatively deeper Lake Eymir, the first biomanipulation led to a clear water state with abundant macrophyte coverage. However, shortly after biomanipulation, the water clarity declined, coinciding with low water level (LWL periods during which nutrient concentrations increased. A second biomanipulation was conducted, mostly during high water level (HWL period, resulting in a major decrease in nutrient concentrations and clearer water, but without an expansion of macrophytes. We conclude that repetitive fish removal may induce recovery but its success may be confounded by high availability of nutrients and adverse hydrological conditions.

  2. Intestinal stoma in patients with colorectal cancer from the perspective of 20-year period of clinical observation.

    Science.gov (United States)

    Banaszkiewicz, Zbigniew; Woda, Łukasz P; Zwoliński, Tomasz; Tojek, Krzysztof; Jarmocik, Paweł; Jawień, Arkadiusz

    2015-01-01

    Intestinal stoma is a procedure most often performed in patients with colorectal cancer. To identify the percentage of patients with colorectal cancer in which the intestinal stoma was performed. We retrospectively analysed 443 patients treated during a 20-year period (1994-2013) due to colorectal cancer, in which the intestinal stoma was made during the first surgical intervention. In the second analysed decade, a significant decrease in the percentage of created stomas, definitive stomas in particular, was observed. Stomas were made significantly more often in patients with a tumour located in the rectum, the left half of the colon, and in patients undergoing urgent surgeries. An increased incidence of intestinal stomas was associated with a higher severity of illness and higher proportion of unresectable and non-radical procedures. The definitive stomas were significantly more often made in men and in patients with tumours located in the rectum, whereas temporary stomas were created significantly more often in patients undergoing urgent operations. In the last decade (2004-2013) the number of intestinal stomas in patients operated due to colorectal cancer was significantly reduced.

  3. A Rare Case of Charcot-Mari-Tooth Disease Type 2S in a 20-year-old Man

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    Natalia A. Shnayder

    2017-12-01

    Full Text Available Charcot-Marie-Tooth disease type 2 (CMT2S is rare form of Charcot-Marie-Tooth disease (CMT that is characterized by a mutation in the IGHMBP2 gene. This gene encodes a helicase superfamily member that binds a specific DNA sequence from the region of the immunoglobulin mu chain switch. Mutation of this gene leads to spinal muscle atrophy with respiratory distress type 1 and CMT2S. This case report presents a 20-year-old male with genetically confirmed CMT2S having clinical respiratory involvement and symmetrically involved lower extremities. DNA sequencing revealed a previously unknown heterozygous mutation in the exone 2 of the IGHMBP2 gene leading to the replacement of the amino acid in the 46 position of the protein (chr11q13.3: 68673587 G>C. These atypical features widen the clinical spectrum of CMT2S. In describing this clinical case, we also improve diagnostic management and try to increase the alertness of various doctors towards neuromuscular diseases, including CMT.

  4. Detection of eating disorders in 16-20 year old female students--perspective from Islamabad, Pakistan.

    Science.gov (United States)

    Shaikh, Masood Ali; Kayani, Ayesha

    2014-03-01

    There are no studies on eating disorders in Pakistani adolescent girls. This study was conducted to determine the opinions, and behaviours pertaining to dieting and body size among 16 to 20 year old female school and college students in Islamabad, Pakistan. This was done through a five-item questionnaire to determine the SCOFF score. The SCOFF acronym has been derived from 'S' from the word "sick" in question number 1.'C' from the word "control" in question number 2. The 'O' comes from the word 'one' in the original question number 3; this original question number 3 of the SCOFF asks about having lost more than 'one' stone weight in the past three months. This question was rephrased to read as whether more than 15 pounds or 6 kilogrammes have been lost. The two 'F's come from questions number 4 and 5 denoting words "fat" and "food", respectively. A total of 1,134 female students participated in the study and 736 (64.9%) respondents scored two or higher on the SCOFF scale; 461 (66.5%) out of 693 were aged 16 to 18, while 275 (62.4%) out of 441 were aged 19 to 20. Results indicated a need for developing clinical practice guidelines for general practitioners and paediatricians to proactively identify and treat potential eating disorders in young Pakistani women.

  5. PREFACE: Celebrating 20 years of Journal of Physics: Condensed Matter—in honour of Richard Palmer Celebrating 20 years of Journal of Physics: Condensed Matter—in honour of Richard Palmer

    Science.gov (United States)

    Ferry, David; Dowben, Peter; Inglesfield, John

    2009-11-01

    This year marks the 20th anniversary of the launch of Journal of Physics: Condensed Matter in 1989. The journal was formed from the merger of Journal of Physics C: Solid State Physics and Journal of Physics F: Metal Physics which had separated in 1971. In the 20 years since its launch, Journal of Physics: Condensed Matter has more than doubled in size, while raising standards. Indeed, Journal of Physics: Condensed Matter has become one of the leading scientific journals for our field. This could not have occurred without great leadership at the top. No one has been more responsible for this growth in both size and quality than our Senior Publisher, Richard Palmer. Richard first started work at IOP in March 1971 as an Editorial Assistant with J. Phys. B After a few months, he transferred to J. Phys.C The following year, the Assistant Editor of J. Phys. C, Malcolm Haines, left suddenly in order to work on his family vineyard in France, and Richard stepped into the breach. In those days, external editors had a much more hands-on role in IOP Publishing and he had to travel to Harwell to be interviewed by Alan Lidiard, the Honorary Editor of J. Phys. C, before being given the job of Assistant Editor permanently. Since J. Phys. C and J. Phys. F re-merged to form Journal of Physics: Condensed Matter, Richard gradually shed his other journal responsibilities, except for Reports on Progress in Physics, to build up Journal of Physics: Condensed Matter. He has worked closely with four Editors-in-Chief of J. Phys. C and five of Journal of Physics: Condensed Matter. When Richard announced his retirement this past winter, we met it with a great deal of both happiness and sadness. Of course, we are happy that he is going to be allowed to enjoy his retirement, but we remain very sad to lose such a valuable member of our team, especially the one who had provided the heart and soul of the journal over its 20 years. We will be able to rely upon the team which Richard ably trained as

  6. Latest German-English Terminology in CADCAM and Robotics

    International Nuclear Information System (INIS)

    Hussain, S M

    2014-01-01

    As a technical translator who speaks German fluently, the author would like to study and display the latest bilingual technical terminology in German being used in hardware, software and process technology involved in CADCAM and ROBOTICS. This will greatly help technical translators to correctly translate difficult texts from this area of technology

  7. (The latest developments of the physical aspects of electrochemistry)

    Energy Technology Data Exchange (ETDEWEB)

    Liu, S.H.

    1990-09-24

    The author was one of 26 invited lecturers to discuss the latest developments of the physical aspects of electrochemistry. He interacted extensively with other lecturers and many participants from developing countries. He also visited with the Director of the Italian Synchrotron Radiation Source now under construction in Trieste, Italy.

  8. Temporal and spatial variation of maximum wind speed days during the past 20 years in major cities of Xinjiang

    Science.gov (United States)

    Baidourela, Aliya; Jing, Zhen; Zhayimu, Kahaer; Abulaiti, Adili; Ubuli, Hakezi

    2018-04-01

    Wind erosion and sandstorms occur in the neighborhood of exposed dust sources. Wind erosion and desertification increase the frequency of dust storms, deteriorate air quality, and damage the ecological environment and agricultural production. The Xinjiang region has a relatively fragile ecological environment. Therefore, the study of the characteristics of maximum wind speed and wind direction in this region is of great significance to disaster prevention and mitigation, the management of activated dunes, and the sustainable development of the region. Based on the latest data of 71 sites in Xinjiang, this study explores the temporal evolution and spatial distribution of maximum wind speed in Xinjiang from 1993 to 2013, and highlights the distribution of annual and monthly maximum wind speed and the characteristics of wind direction in Xinjiang. Between 1993 and 2013, Ulugchat County exhibited the highest number of days with the maximum wind speed (> 17 m/s), while Wutian exhibited the lowest number. In Xinjiang, 1999 showed the highest number of maximum wind speed days (257 days), while 2013 showed the lowest number (69 days). Spring and summer wind speeds were greater than those in autumn and winter. There were obvious differences in the direction of maximum wind speed in major cities and counties of Xinjiang. East of the Tianshan Mountains, maximum wind speeds are mainly directed southeast and northeast. North and south of the Tianshan Mountains, they are mainly directed northwest and northeast, while west of the Tianshan Mountains, they are mainly directed southeast and northwest.

  9. Does perceived physical attractiveness in adolescence predict better socioeconomic position in adulthood? Evidence from 20 years of follow up in a population cohort study.

    Science.gov (United States)

    Benzeval, Michaela; Green, Michael J; Macintyre, Sally

    2013-01-01

    There is believed to be a 'beauty premium' in key life outcomes: it is thought that people perceived to be more physically attractive have better educational outcomes, higher-status jobs, higher wages, and are more likely to marry. Evidence for these beliefs, however, is generally based on photographs in hypothetical experiments or studies of very specific population subgroups (such as college students). The extent to which physical attractiveness might have a lasting effect on such outcomes in 'real life' situations across the whole population is less well known. Using longitudinal data from a general population cohort of people in the West of Scotland, this paper investigated the association between physical attractiveness at age 15 and key socioeconomic outcomes approximately 20 years later. People assessed as more physically attractive at age 15 had higher socioeconomic positions at age 36- in terms of their employment status, housing tenure and income - and they were more likely to be married; even after adjusting for parental socioeconomic background, their own intelligence, health and self esteem, education and other adult socioeconomic outcomes. For education the association was significant for women but not for men. Understanding why attractiveness is strongly associated with long-term socioeconomic outcomes, after such extensive confounders have been considered, is important.

  10. Does perceived physical attractiveness in adolescence predict better socioeconomic position in adulthood? Evidence from 20 years of follow up in a population cohort study.

    Directory of Open Access Journals (Sweden)

    Michaela Benzeval

    Full Text Available There is believed to be a 'beauty premium' in key life outcomes: it is thought that people perceived to be more physically attractive have better educational outcomes, higher-status jobs, higher wages, and are more likely to marry. Evidence for these beliefs, however, is generally based on photographs in hypothetical experiments or studies of very specific population subgroups (such as college students. The extent to which physical attractiveness might have a lasting effect on such outcomes in 'real life' situations across the whole population is less well known. Using longitudinal data from a general population cohort of people in the West of Scotland, this paper investigated the association between physical attractiveness at age 15 and key socioeconomic outcomes approximately 20 years later. People assessed as more physically attractive at age 15 had higher socioeconomic positions at age 36- in terms of their employment status, housing tenure and income - and they were more likely to be married; even after adjusting for parental socioeconomic background, their own intelligence, health and self esteem, education and other adult socioeconomic outcomes. For education the association was significant for women but not for men. Understanding why attractiveness is strongly associated with long-term socioeconomic outcomes, after such extensive confounders have been considered, is important.

  11. Psychological characteristics of male 14- to 20-year-olds on probation and in a residential home in Hong Kong.

    Science.gov (United States)

    Chui, Wing Hong; Chan, Heng Choon Oliver

    2013-02-01

    Little research has been conducted with Hong Kong juvenile probationers. The goals of this study are to examine the psychological characteristics of 14- to 20-year-old male probationers and to test their relationship with broad types of offending--violent and nonviolent. Participants were drawn from the only transitional housing facility for juvenile probationers aged 14-20 years. Offence types and numbers were rated from self-report. Various schedules were rated at interview with consenting young men to describe them in terms of eight psychological characteristics: self-esteem, life satisfaction, social bonding, positive affect, negative affect, impulsivity, pro-criminal attitude and self-perceived life problems. A total of 113 young men completed the assessment, 90% of those eligible. The average psychological profile of these young men was fairly typical for their communities. Pro-criminal attitudes, however, correlated with both main types of offending, whereas main affective state was differently associated. Predominantly, negative affect was associated with violent offending and predominantly positive affect with nonviolent offending. Participants in this study generally reported higher levels of positive psychological well-being than in previous nondelinquent Chinese samples. IMPLICATIONS FOR PRACTICE AND FUTURE RESEARCH: A case-control study comparing such offenders with nondelinquents is required to clarify these findings. A longitudinal design is now indicated to test the direction of relationships between psychological indicators and offending. These steps would be useful precursors to a service evaluation of probation hostels for young offenders. Copyright © 2013 John Wiley & Sons, Ltd.

  12. Shift work and 20-year incidence of acute myocardial infarction: results from the Kuopio Ischemic Heart Disease Risk Factor Study.

    Science.gov (United States)

    Wang, Aolin; Arah, Onyebuchi A; Kauhanen, Jussi; Krause, Niklas

    2016-09-01

    It remains unclear whether different types of shift work impose similar risks for cardiovascular events in middle-aged workers, especially those with pre-existing ischaemic heart disease (IHD). This study investigated the relations between different shift types and incident acute myocardial infarction (AMI) among men with and without pre-existing IHD, respectively. We analysed data on 1891 men, aged 42-60 years at baseline, in the prospective Kuopio Ischemic Heart Disease Risk Factor Study cohort, using Cox proportional hazard models with adjustment for demographic, biological, behavioural and psychosocial job factors. We evaluated the associations of baseline shift work with 20-year incidence of AMI, and their modification by pre-existing IHD, using both stratified analysis and models with product terms between shift work and IHD. Travelling work (at least 3 nights per week away from home) was strongly positively associated with AMI among men with IHD (HR=2.45, 95% CI 1. 08 to 5.59) but not among men without (HR=0.93, 95% CI 0.43 to 2.00). No clear associations were found between other types of shift work and AMI for both men with and without IHD. On both additive and multiplicative scales, baseline IHD status positively modified the association of travelling work with AMI (relative excess risk for interaction=3.23, 95% CI -0.50 to 6.97, p for multiplicative interaction=0.044). We found mixed results for the associations between different types of shift work and AMI among those with and without pre-existing IHD. Future research should investigate these associations and effect modification for a broad spectrum of work schedules. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  13. Changes in environmental tobacco smoke (ETS) exposure over a 20-year period: cross-sectional and longitudinal analyses

    Science.gov (United States)

    Jefferis, Barbara J; Thomson, Andrew G; Lennon, Lucy T; Feyerabend, Colin; Doig, Mira; McMeekin, Laura; Wannamethee, S Goya; Cook, Derek G; Whincup, Peter H

    2009-01-01

    Aims To examine long-term changes in environmental tobacco smoke (ETS) exposure in British men between 1978 and 2000, using serum cotinine. Design Prospective cohort: British Regional Heart Study. Setting General practices in 24 towns in England, Wales and Scotland. Participants Non-smoking men: 2125 studied at baseline [questionnaire (Q1): 1978–80, aged 40–59 years], 3046 studied 20 years later (Q20: 1998–2000, aged 60–79 years) and 1208 studied at both times. Non-smokers were men reporting no current smoking with cotinine < 15 ng/ml at Q1 and/or Q20. Measurements Serum cotinine to assess ETS exposure. Findings In cross-sectional analysis, geometric mean cotinine level declined from 1.36 ng/ml [95% confidence interval (CI): 1.31, 1.42] at Q1 to 0.19 ng/ml (95% CI: 0.18, 0.19) at Q20. The prevalence of cotinine levels ≤ 0.7 ng/ml [associated with low coronary heart disease (CHD) risk] rose from 27.1% at Q1 to 83.3% at Q20. Manual social class and northern region of residence were associated with higher mean cotinine levels both at Q1 and Q20; older age was associated with lower cotinine level at Q20 only. Among 1208 persistent non-smokers, cotinine fell by 1.47 ng/ml (95% CI: 1.37, 1.57), 86% decline. Absolute falls in cotinine were greater in manual occupational groups, in the Midlands and Scotland compared to southern England, although percentage decline was very similar across groups. Conclusions A marked decline in ETS exposure occurred in Britain between 1978 and 2000, which is likely to have reduced ETS-related disease risks appreciably before the introduction of legislation banning smoking in public places. PMID:19207361

  14. Assessing the gap in female authorship in the journal Emergency Radiology: trends over a 20-year period.

    Science.gov (United States)

    McKenzie, Kristopher; Ramonas, Milita; Patlas, Michael; Katz, Douglas S

    2017-12-01

    To examine trends in female authorship in the journal Emergency Radiology from January 1994 to December 2014. We obtained institutional review board approval for our study. We retrospectively reviewed a total of 1617 articles published in the journal Emergency Radiology over a 20-year period. Original articles, case reports, review articles, and pictorial essays were included. The first and last position author's gender was categorized as female or male. We analyzed trends by comparing the first and last position authors of original articles from the first and last year reviewed. We utilized Chi-square test for statistical analysis, with a p value gender of 96% of the authors. Overall, female authors were 21% of first position authors (290 of 1368) and 15% of last position authors (183 of 1246). Thirty-two percent of articles with female last position authors also had female first position authors (58 of 183). There was a statistically significant increase in female last position authors, from 12.9% in 1994 to 21.3% in 2014 (p = 0.026), a non-significant increase in female first position authors, from 17.5% in 1994 to 20.9% in 2014 (p = 0.514), and a non-significant increase in articles with both a first and last female author, from 25% in 1994 to 35% in 2014 (p = 0.593). Over the last 20 years, there has been a statistically significant upward trend in female last position authors publishing in the journal Emergency Radiology.

  15. 20-years of population-based cancer registration in hepatitis B and liver cancer prevention in the Gambia, West Africa.

    Directory of Open Access Journals (Sweden)

    Ebrima Bah

    Full Text Available The Gambia Hepatitis Intervention Study (GHIS was designed as a randomised control trial of infant hepatitis B vaccination applied to public health policy, with the main goal of preventing primary liver cancer later in adult life in The Gambia. To that effect, the National Cancer Registry of The Gambia (NCR, a population-based cancer registry (PBCR, was established in 1986 to actively collect data on all cancer diagnosis nation-wide. We extracted 20-years (1990-2009 of data to assess for the first time, the evolution of the most common cancers, also describe and demonstrate the role of the PBCR in a hepatitis B and liver cancer prevention programme in this population.We estimated Age-Standardised Incidence Rates (ASR (W of the most common cancers registered during the period by gender. The registration period was divided into four 5-year intervals and incidence rates were estimated for each interval. The most common cancers in males were liver, prostate, lung plus bronchus, non-Hodgkin lymphoma (NHL and stomach, accounting for 60%, 5%, 4%, 5% and 3%, respectively. Similarly, cancers of the cervix uteri, liver, breast and NHL, were the most common in females, accounting for 33%, 24%, 11% and 4% of the female cancers, respectively.Cancer incidence has remained relatively stable over time, but as shown elsewhere in sub-Saharan Africa the disease is a threat in The Gambia. The infection related cancers which are mostly preventable (HBV in men and HPV/HIV in women were the most common. At the moment the data is not enough to detect an effect of hepatitis B vaccination on liver cancer incidence in The Gambia. However, we observed that monitoring case occurrence through PBCR is a key public health pre-requisite for rational planning and implementation of targeted interventions for improving the health of the population.

  16. Predictors of Positive Outcomes in Offspring of Depressed Parents and Non-depressed Parents Across 20 Years

    Science.gov (United States)

    Verdeli, Helen; Wickramaratne, Priya; Warner, Virginia; Mancini, Anthony; Weissman, Myrna

    2014-01-01

    Understanding differences in factors leading to positive outcomes in high-risk and low-risk offspring has important implications for preventive interventions. We identified variables predicting positive outcomes in a cohort of 235 offspring from 76 families in which one, both, or neither parent had major depressive disorder. Positive outcomes were termed resilient in offspring of depressed parents, and competent in offspring of non-depressed parents, and defined by two separate criteria: absence of psychiatric diagnosis and consistently high functioning at 2, 10, and 20 years follow-up. In offspring of depressed parents, easier temperament and higher self-esteem were associated with greater odds of resilient outcome defined by absence of diagnosis. Lower maternal overprotection, greater offspring self-esteem, and higher IQ were associated with greater odds of resilient outcome defined by consistently high functioning. Multivariate analysis indicated that resilient outcome defined by absence of diagnosis was best predicted by offspring self-esteem; resilient outcome defined by functioning was best predicted by maternal overprotection and self-esteem. Among offspring of non-depressed parents, greater family cohesion, easier temperament and higher self-esteem were associated with greater odds of offspring competent outcome defined by absence of diagnosis. Higher maternal affection and greater offspring self-esteem were associated with greater odds of competent outcome, defined by consistently high functioning. Multivariate analysis for each criterion indicated that competent outcome was best predicted by offspring self-esteem. As the most robust predictor of positive outcomes in offspring of depressed and non-depressed parents, self-esteem is an important target for youth preventive interventions. PMID:25374449

  17. [Lung cancer in Avila province, Spain. Incidence rates, epidemiolgy of the year 2012 and trends in the last 20 years].

    Science.gov (United States)

    Hernández-Hernández, J R; Moreno de Vega-Herrero, M B; Iglesias-Heras, M; García-García, R; Hernández-Terciado, F; Celdrán-Gil, J

    2015-10-01

    To determine the extent of lung cancer in Alvila. Its incidence rates and significant epidemiological aspects of the year 2012 were recorded, and the results of each 5-year period (up to 20 years) were compared with those of known studies conducted using the same methodology. A prospective study was conducted on all patients diagnosed with lung cancer in the Province of Avila throughout the year 2012. A total of 81 patients were diagnosed, of whom 70 were males and 11 females, with a mean age of 72.1 years (range: 44-91), and was higher than that found in previous studies. This gave gross, and adjusted to the standard world population, incidence rates in 2012 of 80.99 and 31.23 per 100,000, respectively, in males, and 12.97 and 5.68 per 100,000, respectively in females. These rates are lower in both sexes than those found in Alvila in 2002. In 2012, 80.25% had been smokers (90% of males and 18.18% of the women), although, on diagnosis, 68.75% had quit smoking. A clinical-radiological diagnosis was made in 9 (11.1%), with a histocytological diagnosis in 72 (88.9%). The histological types were: adenocarcinomas in 37.5%; squamous in 33.3%; microcytic in 13.8%; undifferentiated non-small cell in 11.1%; large cell in 2.77%, and carcinoid in 1.38%. The most frequent treatments were chemotherapy (50.6%), symptomatic (23.4%), and surgery (12.3%). The incidence of lung cancer in Avila has decreased in both sexes in the last 10 years. In 2012, the patients have been older, the majority with adenocarcinoma histology, and receiving chemotherapy. Copyright © 2014 Sociedad Española de Médicos de Atención Primaria (SEMERGEN). Publicado por Elsevier España, S.L.U. All rights reserved.

  18. PET and PET/CT with radiolabeled choline in prostate cancer: a critical reappraisal of 20 years of clinical studies

    Energy Technology Data Exchange (ETDEWEB)

    Giovacchini, Giampiero; Giovannini, Elisabetta; Leoncini, Rossella; Riondato, Mattia; Ciarmiello, Andrea [S. Andrea Hospital, Nuclear Medicine Department, La Spezia (Italy)

    2017-09-15

    We here aim to provide a comprehensive and critical review of the literature concerning the clinical applications of positron emission tomography/computed tomography (PET/CT) with radiolabeled choline in patients with prostate cancer (PCa). We will initially briefly summarize the historical context that brought to the synthesis of [{sup 11}C]choline, which occurred exactly 20 years ago. We have arbitrarily grouped the clinical studies in three different periods, according to the year in which they were published and according to their relation with their applications in urology, radiotherapy and oncology. Studies at initial staging and, more extensively, studies in patients with biochemical failure, as well as factors predicting positive PET/CT will be reviewed. The capability of PET/CT with radiolabeled choline to provide prognostic information on PCa-specific survival will also be examined. The last sections will be devoted to the use of radiolabeled choline for monitoring the response to androgen deprivation therapy, radiotherapy, and chemotherapy. The accuracy and the limits of the technique will be discussed according to the information available from standard validation processes, including biopsy or histology. The clinical impact of the technique will be discussed on the basis of changes induced in the management of patients and in the evaluation of the response to therapy. Current indications to PET/CT, as officially endorsed by guidelines, or as routinely performed in the clinical practice will be illustrated. Emphasis will be made on methodological factors that might have influenced the results of the studies or their interpretation. Finally, we will briefly highlight the potential role of positron emission tomography/magnetic resonance and of new radiotracers for PCa imaging. (orig.)

  19. Changing demographics of spinal cord injury over a 20-year period: a longitudinal population-based study in Scotland.

    Science.gov (United States)

    McCaughey, E J; Purcell, M; McLean, A N; Fraser, M H; Bewick, A; Borotkanics, R J; Allan, D B

    2016-04-01

    A retrospective cohort study. To review demographic trends in traumatic spinal cord injury (TSCI) and non-traumatic spinal cord injury (NTSCI). The Queen Elizabeth National Spinal Injuries Unit (QENSIU), sole provider of treatment for TSCI in Scotland; a devolved region of the UK National Health Service. A retrospective review of the QENSIU database was performed between 1994 and 2013. This database includes demographic and clinical data from all new TSCI patients in Scotland, as well as patients with severe NTSCI. Over this 20-year period there were 1638 new cases of TSCI in Scotland; 75.2% occurring in males. TSCI incidence increased non-significantly (13.3 per million population to 17.0), while there were significant increases in mean age at time of TSCI (44.1-52.6 years), the proportion of TSCIs caused by falls (41-60%), the proportion of TSCIs resulting in an American Spinal Injury Association Impairment Scale score of C and D on admission (19.7-28.6% and 34.5-39.5%, respectively) and the proportion of cervical TSCIs (58.4-66.3%). The increase in cervical TSCI was specifically due to an increase in C1-C4 lesions (21.7-31.2%). NTSCI patients (n=292) were 5 years older at injury, more likely to be female (68.1% male) and had a range of diagnoses. This study supports the suggestion that demographic profiles in SCI are subject to change. In this population, of particular concern is the increasing number of older patients and those with high level tetraplegia, due to their increased care needs. Prevention programmes, treatment pathways and service provision need to be adjusted for optimum impact, improved outcome and long-term care for their target population.

  20. A 20-year multicentre outcome analysis of salvage mechanical circulatory support for refractory cardiogenic shock after cardiac surgery

    Directory of Open Access Journals (Sweden)

    Maziar Khorsandi

    2016-11-01

    Full Text Available Abstract Background Refractory post-cardiotomy cardiogenic shock (PCCS is a relatively rare phenomenon that can lead to rapid multi-organ dysfunction syndrome and is almost invariably fatal without advanced mechanical circulatory support (AMCS, namely extra-corporeal membrane oxygenation (ECMO or ventricular assist devices (VAD. In this multicentre observational study we retrospectively analyzed the outcomes of salvage venoarterial ECMO (VA ECMO and VAD for refractory PCCS in the 3 adult cardiothoracic surgery centres in Scotland over a 20-year period. Methods The data was obtained through the Edinburgh, Glasgow and Aberdeen cardiac surgery databases. Our inclusion criteria included any adult patient from April 1995 to April 2015 who had received salvage VA ECMO or VAD for PCCS refractory to intra-aortic balloon pump (IABP and maximal inotropic support following adult cardiac surgery. Results A total of 27 patients met the inclusion criteria. Age range was 34–83 years (median 51 years. There was a large male predominance (n = 23, 85 %. Overall 23 patients (85 % received VA ECMO of which 14 (61 % had central ECMO and 9 (39 % had peripheral ECMO. Four patients (15 % were treated with short-term VAD (BiVAD = 1, RVAD = 1 and LVAD = 2. The most common procedure-related complication was major haemorrhage (n = 10. Renal failure requiring renal replacement therapy (n = 7, fatal stroke (n = 5, septic shock (n = 2, and a pseudo-aneurysm at the femoral artery cannulation site (n = 1 were also observed. Overall survival to hospital discharge was 40.7 %. All survivors were NYHA class I-II at 12 months’ follow-up. Conclusion AMCS for refractory PCCS carries a survival benefit and achieves acceptable functional recovery despite a significant complication rate.

  1. NATIONAL POLICY FOR ACADEMIC MOBILITY IN RUSSIA AND THE BRICS COUNTRIES: 20 YEARS OF THE BOLOGNA PROCESS IMPLEMENTATION

    Directory of Open Access Journals (Sweden)

    D. Teplyakov

    2018-01-01

    Full Text Available The article analyses the Russian Federal Education Programmes from the aspect of their impact on student and academic staff mobility. The subject of the analysis is the programmes adopted for the period 2000 to 2020 and their implementation reports. A cluster of academic mobility forms compiled by the authors is based on two groups: academic staff and students. The forms of academic staff mobility have been identified as: (1 a migration flow: outward and incoming; and (2 purpose: teaching and research. The forms of student mobility have been identified as: (1 migration flow: outward and incoming; and (2 purpose: credit mobility and degree mobility. The cluster is based on the National Reports on the Implementation of the Bologna Process by different countries from 2012 to 2015 and the Russian Federal Education Programmes. The analysis finds that academic mobility in Russia has been an indicator of the development of education programmes for almost 20 years. During this period, the government’s approach to academic mobility has undergone a change from a simple reference as an expected result to the establishing of quantitative indicators. The four quantitative indicators of academic mobility have been in place since 2000. As a result of the analysis, the authors conclude that among the forms of student mobility the most developed is the incoming degree mobility of international students. The student outward credit mobility is the least developed of the four indicators. In the current situation, it is necessary to reform and liberalise the recognition of study abroad periods for Russian students. Without reform, it will be difficult to achieve the target set by the government to have 6 percent of students studying abroad for at least one semester by 2020. The data for 2016 show that only a few higher education institutions have approached the target. The authors also identify problems relating to academic staff mobility.

  2. 20-Years of Population-Based Cancer Registration in Hepatitis B and Liver Cancer Prevention in The Gambia, West Africa

    Science.gov (United States)

    Bah, Ebrima; Carrieri, Maria Patrizia; Hainaut, Pierre; Bah, Yusupha; Nyan, Ousman; Taal, Makie

    2013-01-01

    Background The Gambia Hepatitis Intervention Study (GHIS) was designed as a randomised control trial of infant hepatitis B vaccination applied to public health policy, with the main goal of preventing primary liver cancer later in adult life in The Gambia. To that effect, the National Cancer Registry of The Gambia (NCR), a population-based cancer registry (PBCR), was established in 1986 to actively collect data on all cancer diagnosis nation-wide. We extracted 20-years (1990-2009) of data to assess for the first time, the evolution of the most common cancers, also describe and demonstrate the role of the PBCR in a hepatitis B and liver cancer prevention programme in this population. Methods and Findings We estimated Age-Standardised Incidence Rates (ASR (W)) of the most common cancers registered during the period by gender. The registration period was divided into four 5-year intervals and incidence rates were estimated for each interval. The most common cancers in males were liver, prostate, lung plus bronchus, non-Hodgkin lymphoma (NHL) and stomach, accounting for 60%, 5%, 4%, 5% and 3%, respectively. Similarly, cancers of the cervix uteri, liver, breast and NHL, were the most common in females, accounting for 33%, 24%, 11% and 4% of the female cancers, respectively. Conclusions Cancer incidence has remained relatively stable over time, but as shown elsewhere in sub-Saharan Africa the disease is a threat in The Gambia. The infection related cancers which are mostly preventable (HBV in men and HPV/HIV in women) were the most common. At the moment the data is not enough to detect an effect of hepatitis B vaccination on liver cancer incidence in The Gambia. However, we observed that monitoring case occurrence through PBCR is a key public health pre-requisite for rational planning and implementation of targeted interventions for improving the health of the population. PMID:24098724

  3. Natural hazards and decision-making in the most densely populated country in the American continent: a 20-year perspective

    Science.gov (United States)

    Cruz Martínez, Celina; Cepeda, Jose

    2010-05-01

    With a population density of ~300 per km2, El Salvador is the most densely populated country in the American continent and the capital, San Salvador, is probably the city in the Americas most frequently hit by natural hazards, earthquakes in particular. As a consequence of a magnitude 5.4 earthquake in 1986, 1500 people were killed, with as many as one-third of these casualties associated to the collapse of engineered structures, a high rate compared to contemporary figures worldwide. Four years earlier, during a long precipitation period in September 1982, a debris flow was triggered from the summit of the San Salvador volcano and travelled ~4 km for about one hour before it killed up to 500 people in an area to the North-West of the Metropolitan Area of San Salvador (AMSS). This same area had been previously hit by a similar event 50 years earlier, but with no consequences at that time since it was uninhabited. These are only some examples of the main facts that motivated the creation of the Office for Urban Planning of the Metropolitan Area of San Salvador (OPAMSS) in 1990. This institution is an autonomous municipal organisation whose functions and attributes comprise the planning and control of urban development. After 20 years of the foundation of OPAMSS, this paper presents its history and evolution, the main achievements and challenges, focusing on how the institution has been shaped by some key milestones, such as the earthquake-triggered landslide at Las Colinas neighbourhood in January 2001, which killed ~600 people in the Western AMSS, and the widespread flooding in October 2005 after the urban drainage network collapsed during Hurricane Stan. The development of OPAMSS as a key organisation in land use management and decision-making is an example that illustrates how the integration of technical and legal aspects can be oriented towards the improvement of governance at the scale of metropolitan areas.

  4. Lessons learnt from 20 years surveillance of malaria drug resistance prior to the policy change in Burkina Faso.

    Science.gov (United States)

    Tinto, Halidou; Valea, Innocent; Ouédraogo, Jean-Bosco; Guiguemdé, Tinga Robert

    2016-01-01

    The history of drug resistance to the previous antimalarial drugs, and the potential for resistance to evolve to Artemisinin-based combination therapies, demonstrates the necessity to set-up a good surveillance system in order to provide early warning of the development of resistance. Here we report a review summarizing the history of the surveillance of drug resistance that led to the policy change in Burkina Faso. The first Plasmodium falciparum Chloroquine-Resistance strain identified in Burkina Faso was detected by an in vitro test carried out in Koudougou in 1983. Nevertheless, no further cases were reported until 1987, suggesting that resistant strains had been circulating at a low prevalence before the beginning of the systematic surveillance system from 1984. We observed a marked increase of Chloroquine-Resistance in 2002-2003 probably due to the length of follow-up as the follow-up duration was 7 or 14 days before 2002 and 28 days from 2002 onwards. Therefore, pre-2002 studies have probably under-estimated the real prevalence of Chloroquine-Resistance by not detecting the late recrudescence. With a rate of 8.2% treatment failure reported in 2003, Sulfadoxine-Pyrimethamine was still efficacious for the treatment of uncomplicated malaria in Burkina Faso but this rate might rapidly increase as the result of its spreading from neighboring countries and due to its current use for both the Intermittent Preventive Treatment in pregnant women and Seasonal Malaria Chemoprophylaxis. The current strategy for the surveillance of the Artemisinin-based combination treatments resistance should build on lessons learnt under the previous period of 20 years surveillance of Chloroquine and Sulfadoxine-Pyrimethamine resistance (1994-2004). The most important aspect being to extend the number of sentinel sites so that data would be less patchy and could help understanding the dynamic of the resistance.

  5. 20 Years of Developing Capacity for Action-Oriented Collaborative Regional Research in the Asia-Pacific Region

    Science.gov (United States)

    Tupas, L. M.; Stevenson, L. A.

    2015-12-01

    During its 3rd strategic phase, which ran from 2010 to 2015, the APN provided support for 123 projects through its competitive collaborative regional research and capacity development programmes. With over 250 peer-reviewed papers and the underlying philosophy that the regional research it undertakes engages at least two developing countries, the 3rd strategic phase is not only improving the research capabilities of nations in the region, but is engaging the developing country community in underpinning policy-relevant research. The extent to which science is contributing to policy is further evident in that 69% of the activities conducted had some form of science-policy mechanism built in to the project activities. The period of the 3rd Strategic Phase has been witness to significant changes in the make-up of the "conventional" global change arena, with the transition of some global change programmes into the new "Future Earth" initiative. At the same time, major events such as the Rio+20 Summit, the post-2015 Sustainable Development Goals, the establishment of an IPCC-related platform for biodiversity, i.e. IPBES, and the evolving engagement of science and policy communities has kept the APN busy at what it does best - networking and partnering with the international community. The APN has embraced these changes through its dynamism, allowing the APN to meet not only the needs of the scientists and decision makers its serves in the region but those of the international science communities as well. The challenge for the APN in its next two decades will be to ensure alignment with the transforming global change arena. With key phrases such as "policy-relevant science" and "science-policy interactions" being adopted broadly by the community at large these days, the APN's niche in the global community has received considerable recognition, particularly as other institutions strive to adopt similar practices that the APN has built over the last 20 years.

  6. Understory response to varying fire frequencies after 20 years of prescribed burning in an upland oak forest

    Science.gov (United States)

    Burton, J.A.; Hallgren, S.W.; Fuhlendorf, S.D.; Leslie, David M.

    2011-01-01

    Ecosystems in the eastern United States that were shaped by fire over thousands of years of anthropogenic burning recently have been subjected to fire suppression resulting in significant changes in vegetation composition and structure and encroachment by invasive species. Renewed interest in use of fire to manage such ecosystems will require knowledge of effects of fire regime on vegetation. We studied the effects of one aspect of the fire regime, fire frequency, on biomass, cover and diversity of understory vegetation in upland oak forests prescribe-burned for 20 years at different frequencies ranging from zero to five fires per decade. Overstory canopy closure ranged from 88 to 96% and was not affected by fire frequency indicating high tolerance of large trees for even the most frequent burning. Understory species richness and cover was dominated by woody reproduction followed in descending order by forbs, C3 graminoids, C4 grasses, and legumes. Woody plant understory cover did not change with fire frequency and increased 30% from one to three years after a burn. Both forbs and C3 graminoids showed a linear increase in species richness and cover as fire frequency increased. In contrast, C4 grasses and legumes did not show a response to fire frequency. The reduction of litter by fire may have encouraged regeneration of herbaceous plants and helped explain the positive response of forbs and C3 graminoids to increasing fire frequency. Our results showed that herbaceous biomass, cover, and diversity can be managed with long-term prescribed fire under the closed canopy of upland oak forests. ?? 2011 Springer Science+Business Media B.V.

  7. A 20 year independent record of sea surface temperature for climate from Along-Track Scanning Radiometers

    Science.gov (United States)

    Merchant, Christopher J.; Embury, Owen; Rayner, Nick A.; Berry, David I.; Corlett, Gary K.; Lean, Katie; Veal, Karen L.; Kent, Elizabeth C.; Llewellyn-Jones, David T.; Remedios, John J.; Saunders, Roger

    2012-12-01

    A new record of sea surface temperature (SST) for climate applications is described. This record provides independent corroboration of global variations estimated from SST measurements made in situ. Infrared imagery from Along-Track Scanning Radiometers (ATSRs) is used to create a 20 year time series of SST at 0.1° latitude-longitude resolution, in the ATSR Reprocessing for Climate (ARC) project. A very high degree of independence of in situ measurements is achieved via physics-based techniques. Skin SST and SST estimated for 20 cm depth are provided, with grid cell uncertainty estimates. Comparison with in situ data sets establishes that ARC SSTs generally have bias of order 0.1 K or smaller. The precision of the ARC SSTs is 0.14 K during 2003 to 2009, from three-way error analysis. Over the period 1994 to 2010, ARC SSTs are stable, with better than 95% confidence, to within 0.005 K yr-1(demonstrated for tropical regions). The data set appears useful for cleanly quantifying interannual variability in SST and major SST anomalies. The ARC SST global anomaly time series is compared to the in situ-based Hadley Centre SST data set version 3 (HadSST3). Within known uncertainties in bias adjustments applied to in situ measurements, the independent ARC record and HadSST3 present the same variations in global marine temperature since 1996. Since the in situ observing system evolved significantly in its mix of measurement platforms and techniques over this period, ARC SSTs provide an important corroboration that HadSST3 accurately represents recent variability and change in this essential climate variable.

  8. Increasing Incidence and Age at Diagnosis among Children with Type 1 Diabetes Mellitus over a 20-Year Period in Auckland (New Zealand)

    Science.gov (United States)

    Derraik, José G. B.; Reed, Peter W.; Jefferies, Craig; Cutfield, Samuel W.; Hofman, Paul L.; Cutfield, Wayne S.

    2012-01-01

    Background We aimed to evaluate the incidence of type 1 diabetes mellitus in children Auckland region (New Zealand) over 20 years (1990–2009). Methods We performed a retrospective review of all patients Auckland over 20 years. Contrary to other studies, age at diagnosis has increased and the greatest rise in incidence occurred in children 10–14 yr. There was little change in BMI SDS in this population, providing no support for the ‘accelerator hypothesis’. PMID:22389717

  9. Publication trends of research on diabetes mellitus and T cells (1997-2016: A 20-year bibliometric study.

    Directory of Open Access Journals (Sweden)

    Ye Gao

    Full Text Available Diabetes Mellitus (DM is a huge burden for human health. Recent studies show the close relationship between DM and T cells. We investigated the trend in DM and T cells research.Using the Web of Science database, we searched the publications on DM and T cells in 1997-2016, and studied the source data using bibliometric methodology. Excel 2016, GraphPad Prism 5, and VOSviewer software were used to analyze the publication trend in DM and T cells research.We found a total of 1077 publications with 38109 citations up to January 23, 2017. The highest contribution came from the United States, with 48.38% of the publications, 61.44% of the citations and the highest H-index (74. China had the 5th place for total publications, but ranked 11th both for citation frequency (604 and H-index (13. The inflection point of the global DM and T cells publications was in 2000. Journal of Immunology published the most related articles (164. Santamaria P. was the leading scholar in this field with the most publications (35. The keywords "regulatory T cell" and "autoimmune diabetes" were mentioned more than 300 times. Furthermore, type 2 (T2DM, T cell immunoglobulin and mucin domain (TIM and obesity are becoming popular research topics in this field.The quantity of publications on DM and T cells grew rapidly around year 2000, but has relatively decreased recently. The United States had the leading position in global research. There was a discrepancy between productivity and quality of publications from China. Latest progress is most likely first published by the Journal of Immunology. Santamaria P., Roep B.O. and Peakman M. were the pioneer scholars in this field. Most researchers have focused on "regulatory T cell" and "autoimmune diabetes" research. In future, T2DM, TIM and obesity may be the popular areas.

  10. Using research to change public policy: reflections on 20 years of effort to eliminate corporal punishment in schools.

    Science.gov (United States)

    Hyman, I A

    1996-10-01

    In the past 20 years, over half of the states have abolished corporal punishment in schools. Without the use of ethically questionable, experimental studies in which students were randomly assigned to paddlings, advocacy researchers were able to integrate the literature and experimental research on reward, punishment, and motivation, and conduct enough studies to provide sufficient data for policy changes. Further, every popular school discipline training program promotes well-proven positive and preventive techniques and punishments that do not inflict physical pain. Research on alternatives, naturalistic evidence from schools that eliminated corporal punishment, and survey research prove that schools do not need to use corporal punishment. The movement to eliminate parental spanking is at a stage similar to the beginning of the school corporal punishment debate in 1976. Even though some studies may show that moderate parental spanking may do no short-term harm, there is little scientific evidence that it is necessary. There are no data to indicate that schools which eliminated corporal punishment became any worse. The same demographic factors and political polarizations that have kept about half of American school children from the protections against paddling afforded students in almost all other Western democracies also impede the movement to eliminate parental spanking. Since we know that corporal punishment too often leads to excesses, and since we have a multitude of effective positive approaches, what is the worst thing that would happen if all Americans stopped hitting children in any setting? The same children who are hit for misbehavior would continue that misbehavior and other ineffective punishments would be used. Most parents and teachers would discover what behavioral scientists already know. A combination of reward, positive motivational techniques and appropriate, nonphysical punishments would prevent most misbehavior. Other factors being equal, in

  11. Modelling and simulation SSM: latest state of the art technology

    CSIR Research Space (South Africa)

    Jahajeeah, N

    2005-10-01

    Full Text Available as one phase ? One Phase model ?Wider volume solid fraction 0 – 1 ? Implementation in Power Law Cut-Off Model (PLCO) of Procast Supporting the Manufacturing and Materials Industry in its quest for global competitiveness Assumptions of the PLCO Model... and Materials Industry in its quest for global competitiveness Modelling and Simulation SSM Latest state of the art technology N Jahajeeah Supporting the Manufacturing and Materials Industry in its quest for global competitiveness BEHAVIOUR OF THIXOTROPIC...

  12. Latest research progress on food waste management: a comprehensive review

    Science.gov (United States)

    Zhu, Shangzhen; Gao, Hetong; Duan, Lunbo

    2018-05-01

    Since a large amount of food supplying is provided as a basic line measuring increasing residents’ life standard, food waste has become progressively numeral considerable. Much attention has been drawn to this problem. This work gave an overview on latest researches about anaerobic digestion, composting, generalized management and other developments on management of food waste. Different technologies were introduced and evaluated. Further views on future research in such a field were proposed.

  13. Mobile application for reading latest news from multiple sources

    OpenAIRE

    Watzak, Aleš

    2013-01-01

    Thesis covers development of an application for mobile devices running Android operating system. It enables users to keep up to date with the latest news, weather and traffic report. News delivery service is available wherever there is Internet access and not limited to a physical location like an office with desktop computer. To this end we developed two applications. First represents server part of the application and runs on Apache web server. The second part is a client application which ...

  14. Latest results on the performance of the multigap resistive plate chamber used for the ALICE TOF

    International Nuclear Information System (INIS)

    Akindinov, A.N.; Alici, A.; Anselmo, F.

    2004-01-01

    For the identification of particles in the momentum range 0.5-2.5GeV/c, the ALICE experiment uses a Time Of Flight array consisting of Multigap Resistive Plate Chambers (MRPC) in the form of long strips. The design of the detector elements is as follows : double stack MRPCs with glass resistive plates and 5 gas gaps of 250μm per stack. The latest results on the performance of these MRPCs are presented. Typical values of time resolution σ are better than 50ps, with an efficiency of 99.9% and a long, more than 1.5kV, streamer-free plateau

  15. Latest results on the performance of the multigap resistive plate chamber used for the ALICE TOF

    CERN Document Server

    Akindinov, A; Anselmo, F; Antonioli, P; Basile, M; Cara Romeo, G; Cifarelli, Luisa; Cindolo, F; Cosenza, F; D'Antone, I; De Caro, A; De Pasquale, S; Di Bartolomeo, A; Fusco-Girard, M; Golovine, V; Guerzoni, M; Guida, M; Hatzifotiadou, D; Kaidalov, A B; Kim, D H; Kim, D W; Kisselev, S M; Laurenti, G; Lioublev, E; Lee, K; Lee, S C; Luvisetto, M L; Margotti, A; Martemyanov, A N; Massera, F; Meneghini, S; Michinelli, R; Nania, R; Otiougova, P; Pancaldi, G; Pesci, A; Pilastrini, R; Pinazza, O; Polozov, P A; Rizzi, M; Scapparone, E; Scioli, G; Sellitto, S B; Semeria, F; Serra, S; Smirnitsky, A V; Tchoumakov, M M; Ugolini, E; Usenko, E; Valenti, G; Voloshin, K G; Williams, M C S; Zagreev, B V; Zampolli, C; Zichichi, A; Zucchini, A; Zuffa, M

    2004-01-01

    For the identification of particles in the momentum range 0.5-2.5 GeV /c, the ALICE experiment uses a Time Of Flight array consisting of Multigap Resistive Plate Chambers (MRPC) in the form of long strips. The design of the detector elements is as follows: double stack MRPCs with glass resistive plates and 5 gas gaps of 250 mum per stack. The latest results on the performance of these MRPCs are presented. Typical values of time resolution sigma are better than 50 ps, with an efficiency of 99.9% and a long, more than 1.5kV, streamer-free plateau.

  16. Soil management, fertilization and plant nutrition in organic systems in Spain: A review of the research in last 20 years

    Science.gov (United States)

    Gonzalvez, Victor; Raigon Jiménez, M.° Dolores

    2016-04-01

    The Spanish Society for Agroecology/Organic Farming (SEAE) is a private charity association, founded in 1992, with the purpose to support organic farming practitioners. The principal aim is to join the efforts farmers, technicians and scientifics and others organizations and persons, related to develop sustainable agriculture systems, based on ecological and socioeconomic principles promoted by the international organic farming movement, with the purpose to obtain foods and first resources with high quality, considering the vulnerability of the environment and preserving the soil fertility, with the optimal and adequate use of the local resources, taking in account the rural culture and the ethical value of the social development and the life quality. One of the most relevant and know activity of SEAE is the celebration of one (scientific) Congress every two years. This is the most important event on this issue in Spain. In the last 20 year, eleven events of this kind have been organised in 11 different places (Toledo, Pamplona, Valencia, Córdoba, Gijón-Asturias, Almeria, Zaragoza, Bullas-Murcia, Lleida, Albacete, Vitoria-Gasteiz). The average participation in the Congress was growing up from 100 to 350 persons), from all over Spain. During this events, researchers, advisors, trainers, politicians and operators (farmers, processors, certifiers, marketers, consumers, etc.) shared and update the scientific results, projects in force, political measures, statistics and proposals to develop the organic farming sector Research in organic farming is still low in Spain and the majority of the results in this matter are being presented as papers in this Congresses. Over 1500 papers from over 100 spanish research groups giving information about the research results have been presented in this events, One of the most relevant topic of this research is done on soil conservation, soil fertility and organic crop fertilization and organic matter management in the soil, after

  17. Latest innovations for tattoo and permanent makeup removal.

    Science.gov (United States)

    Mao, Johnny C; DeJoseph, Louis M

    2012-05-01

    The goal of this article is to reveal the latest techniques and advances in laser removal of both amateur and professional tattoos, as well as cosmetic tattoos and permanent makeup. Each pose different challenges to the removing physician, but the goal is always the same: removal without sequelae. The authors' technique is detailed, and discussion of basic principles of light reflection, ink properties, effects of laser energy and heat, and outcomes and complications of tattoo removal are presented. Copyright © 2012 Elsevier Inc. All rights reserved.

  18. The latest full-scale PWR simulator in Japan

    International Nuclear Information System (INIS)

    Nishimuru, Y.; Tagi, H.; Nakabayashi, T.

    2004-01-01

    The latest MHI Full-scale Simulator has an excellent system configuration, in both flexibility and extendability, and has highly sophisticated performance in PWR simulation by the adoption of CANAC-II and PRETTY codes. It also has an instructive character to display the plant's internal status, such as RCS condition, through animation. Further, the simulation has been verified to meet a functional examination at model plant, and with a scale model test result in a two-phase flow event, after evaluation for its accuracy. Thus, the Simulator can be devoted to a sophisticated and broad training course on PWR operation. (author)

  19. Latest AMS Results on elementary particles in cosmic rays

    Science.gov (United States)

    Kounine, Andrei; AMS Collaboration

    2017-01-01

    AMS-02 is a particle physics detector collecting data on the International Space Station since May 2011. Precision measurements of all elementary charged cosmic ray particles have been performed by AMS using a data sample of 85 billion cosmic ray events collected during the first five years of operations on the Station. The latest AMS results on the fluxes and flux ratios of the elementary cosmic ray particles are presented. They show unique features that require accurate theoretical interpretation as to their origin, be it from dark matter collisions or new astrophysical sources. On behalf of the AMS Collaboration.

  20. Latest developments at the ALBA magnetic measurements laboratory

    Science.gov (United States)

    Marcos, J.; Massana, V.; García, L.; Campmany, J.

    2018-02-01

    ALBA is a third-generation synchrotron light source that has been in operation since 2012 near Barcelona. A magnetic measurements laboratory has been associated with the facility since its very early stages and has been active for the last 20 years. In the first part of this work, the different instruments available at the laboratory are described, and a brief overview of the measurement campaigns carried out during its 20 years of history is presented. In the second part, a more detailed description of the approach to Hall probe measurements adopted at ALBA is offered, with an explanation of the methods and ancillary equipment that have been developed along the years in order to improve the accuracy of the system. In the third part, a new concept of Hall probe bench devoted to the measurement of closed structures is presented. The in-house design and building of a prototype for such a bench is described, together with its mechanical and magnetic characterization. As a conclusion, the first results obtained with this bench are discussed.

  1. The DAFT/FADA Survey status and latest results

    Science.gov (United States)

    Guennou, L.

    2011-12-01

    We present here the latest results obtained from the American French collaboration called the Dark energy American French Team/French American DArk energy Team (DAFT/FADA). The goal of the DAFT/FADA collaboration is to carry out a weak lensing tomography survey of z = 0.4-0.9 rich clusters of galaxies. Unlike supernovae or other methods such as cluster of galaxy counts, weak lensing tomography is purely based on geometry and does not depend on knowledge of the physics of the objects used as distance indicators. In addition, the reason for analyzing observations in the direction of clusters is that the shear signal is enhanced by about 10 over the field. Our work will eventually contain results obtained on 91 rich clusters from the HST archive combined with ground based work to obtain photo-zs. This combination of photo-z and weak lensing tomography will enable us to constrain the equation of state of dark energy. We present here the latest results obtained so far in this study.

  2. Latest Results in SLAC 75-MW PPM Klystrons

    International Nuclear Information System (INIS)

    Sprehn, D.; Caryotakis, G.; Haase, A.; Jongewaard, E.; Laurent, L.; Pearson, C.; Phillips, R.

    2006-01-01

    75 MW X-band klystrons utilizing Periodic Permanent Magnet (PPM) focusing have been undergoing design, fabrication and testing at the Stanford Linear Accelerator Center (SLAC) for almost nine years. The klystron development has been geared toward realizing the necessary components for the construction of the Next Linear Collider (NLC). The PPM devices built to date which fit this class of operation consist of a variety of 50 MW and 75 MW devices constructed by SLAC, KEK (Tsukuba, Japan) and industry. All these tubes follow from the successful SLAC design of a 50 MW PPM klystron in 1996. In 2004 the latest two klystrons were constructed and tested with preliminary results reported at EPAC2004. The first of these two devices was tested to the full NLC specifications of 75 MW, 1.6 microseconds pulse length, and 120 Hz. This 14.4 kW average power operation came with a tube efficiency >50%. The most recent testing of these last two devices will be presented here. Design and manufacturing issues of the latest klystron, due to be tested by the Fall of 2005, are also discussed

  3. Risk of Hyperprolactinemia and Sexual Side Effects in Males 10-20 Years Old Diagnosed with Autism Spectrum Disorders or Disruptive Behavior Disorder and Treated with Risperidone

    NARCIS (Netherlands)

    Roke, Yvette; Buitelaar, Jan K.; Boot, Annemieke M.; Tenback, Diederik; van Harten, Peter N.

    2012-01-01

    Objective: The aim of this study was to investigate the long-term treatment effects of risperidone on prolactin levels and prolactin-related side effects in pubertal boys with autism spectrum disorders (ASD) and disruptive behavior disorders (DBD). Method: Physical healthy 10-20-year-old males with

  4. Long-term outcomes of the Ross procedure in adults with severe aortic stenosis: single-centre experience with 20 years of follow-up.

    Science.gov (United States)

    Kalfa, David; Mohammadi, Siamak; Kalavrouziotis, Dimitri; Kharroubi, Mounir; Doyle, Daniel; Marzouk, Mohamed; Metras, Jacques; Perron, Jean

    2015-01-01

    The optimal prosthesis option for aortic valve replacement in adult patientsreplacement (n=190; 86%) or the subcoronary technique (n=31; 14%). There were 169 patients with bicuspid valves and 33 redo operations including previous aortic valve repair (n=6) and replacement (n=9) for severe AS. Demographic, preoperative, postoperative and longitudinal clinical and echocardiographic data were collected prospectively. The median and mean follow-up were 11.4 years (range: 1-20.1 years) and 10.1±5.9 years, respectively. The follow-up was complete in all patients. Kaplan-Meier actuarial survival analysis was performed to assess long-term survival, freedom from reoperation for autograft and/or homograft failure and freedom from autograft valve insufficiency. Cox regression risk analysis was performed to identify factors associated with autograft or homograft reoperations. The perioperative mortality rate was 0.9% (n=2). The incidence rate of early reoperation for bleeding was 5.9%. The actuarial survival rate at 10 and 15 years following surgery was 92.1 and 90.5%, respectively. Ross-related reoperations occurred in 21 patients during follow-up: autograft dysfunction (n=9), homograft dysfunction (n=6) and both (n=6). The rate of freedom from Ross-related reoperation was 94.7 and 87.7% at 10 and 15 years, respectively. The rate of freedom from reoperation for autograft failure was 97.6 and 91.5%, the rate of freedom from reoperation for homograft failure was 95.7 and 90.8%, and the rate of freedom from moderate or severe autograft regurgitation was 94.1 and 85.6% at 10 and 15 years, respectively. Compared with available aortic bioprosthetic alternatives in young adults with severe AS, the Ross procedure provides an excellent long-term option for patients with predominant severe AS who seek a durable operation without anticoagulation. © The Author 2014. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.

  5. Psychological distress and user experiences with health care provision in persons living with spinal cord injury for more than 20 years

    DEFF Research Database (Denmark)

    Jakimovska, V M; Kostovski, E; Biering-Sørensen, F

    2017-01-01

    were cases according to the GHQ-20. The cases did not differ from non-cases concerning demography, time since injury, injury aetiology, injury severity, marital status or employment status. The regression analysis revealed that cases were associated (P

  6. ''MOSAIK {sup registered}'' 20 years of experience with a cask system for transportation, conditioning and storage of radioactive waste

    Energy Technology Data Exchange (ETDEWEB)

    Gestermann, G. [GNS Gesellschaft fuer Nuklear-Service mbH, Essen (Germany)

    2004-07-01

    In Europe shielding casks for transportation and storage of radioactive waste with higher specific activity are in use. These casks developed by GNS and fabricated from ductile cast iron are called MOSAIK {sup registered} cask. At the moment 4 main types with some subtypes, named MOSAIK {sup registered} I, II, III and 80 T, are in use. The MOSAIK {sup registered} casks are licensed for the German interim storages and the planned final repository MOSAIK {sup registered} II and MOSAIK {sup registered} 80 T are licensed as a type B(U) cask also. Till now more then 4100 MOSAIK {sup registered} cask have been built and loaded with radioactive MAW material.

  7. Challenges of Treating Childhood Medulloblastoma in a Country With Limited Resources: 20 Years of Experience at a Single Tertiary Center in Malaysia.

    Science.gov (United States)

    Rajagopal, Revathi; Abd-Ghafar, Sayyidatul; Ganesan, Dharmendra; Bustam Mainudin, Anita Zarina; Wong, Kum Thong; Ramli, Norlisah; Jawin, Vida; Lum, Su Han; Yap, Tsiao Yi; Bouffet, Eric; Qaddoumi, Ibrahim; Krishnan, Shekhar; Ariffin, Hany; Abdullah, Wan Ariffin

    2017-04-01

    Pediatric medulloblastoma (MB) treatment has evolved over the past few decades; however, treating children in countries with limited resources remains challenging. Until now, the literature regarding childhood MB in Malaysia has been nonexistent. Our objectives were to review the demographics and outcome of pediatric MB treated at the University Malaya Medical Center between January 1994 and December 2013 and describe the challenges encountered. Fifty-one patients with childhood MB were seen at University Malaya Medical Center. Data from 43 patients were analyzed; eight patients were excluded because their families refused treatment after surgery. Headache and vomiting were the most common presenting symptoms, and the mean interval between symptom onset and diagnosis was 4 weeks. Fourteen patients presented with metastatic disease. Five-year progression-free survival (± SE) for patients ≥ 3 years old was 41.7% ± 14.2% (95% CI, 21.3% to 81.4%) in the high-risk group and 68.6% ± 18.6% (95% CI, 40.3% to 100%) in the average-risk group, and 5-year overall survival (± SE) in these two groups was 41.7% ± 14.2% (95% CI, 21.3% to 81.4%) and 58.3% ± 18.6% (95% CI, 31.3% to 100%), respectively. Children younger than 3 years old had 5-year progression-free and overall survival rates (± SE) of 47.6% ± 12.1% (95% CI, 28.9% to 78.4%) and 45.6% ± 11.7% (95% CI, 27.6% to 75.5%), respectively. Time to relapse ranged from 4 to 132 months. Most patients who experienced relapse died within 1 year. Febrile neutropenia, hearing loss, and endocrinopathy were the most common treatment-related complications. The survival rate of childhood MB in Malaysia is inferior to that usually reported in the literature. We postulate that the following factors contribute to this difference: lack of a multidisciplinary neuro-oncology team, limited health care facilities, inconsistent risk assessment, insufficient data in the National Cancer Registry and pathology reports, inadequate long-term follow-up, and cultural beliefs leading to treatment abandonment.

  8. Challenges of Treating Childhood Medulloblastoma in a Country With Limited Resources: 20 Years of Experience at a Single Tertiary Center in Malaysia

    Directory of Open Access Journals (Sweden)

    Revathi Rajagopal

    2017-04-01

    Full Text Available Purpose: Pediatric medulloblastoma (MB treatment has evolved over the past few decades; however, treating children in countries with limited resources remains challenging. Until now, the literature regarding childhood MB in Malaysia has been nonexistent. Our objectives were to review the demographics and outcome of pediatric MB treated at the University Malaya Medical Center between January 1994 and December 2013 and describe the challenges encountered. Methods: Fifty-one patients with childhood MB were seen at University Malaya Medical Center. Data from 43 patients were analyzed; eight patients were excluded because their families refused treatment after surgery. Results: Headache and vomiting were the most common presenting symptoms, and the mean interval between symptom onset and diagnosis was 4 weeks. Fourteen patients presented with metastatic disease. Five-year progression-free survival (± SE for patients ≥ 3 years old was 41.7% ± 14.2% (95% CI, 21.3% to 81.4% in the high-risk group and 68.6% ± 18.6% (95% CI, 40.3% to 100% in the average-risk group, and 5-year overall survival (± SE in these two groups was 41.7% ± 14.2% (95% CI, 21.3% to 81.4% and 58.3% ± 18.6% (95% CI, 31.3% to 100%, respectively. Children younger than 3 years old had 5-year progression-free and overall survival rates (± SE of 47.6% ± 12.1% (95% CI, 28.9% to 78.4% and 45.6% ± 11.7% (95% CI, 27.6% to 75.5%, respectively. Time to relapse ranged from 4 to 132 months. Most patients who experienced relapse died within 1 year. Febrile neutropenia, hearing loss, and endocrinopathy were the most common treatment-related complications. Conclusion: The survival rate of childhood MB in Malaysia is inferior to that usually reported in the literature. We postulate that the following factors contribute to this difference: lack of a multidisciplinary neuro-oncology team, limited health care facilities, inconsistent risk assessment, insufficient data in the National Cancer Registry and pathology reports, inadequate long-term follow-up, and cultural beliefs leading to treatment abandonment.

  9. Radiation therapy with or without primary limited surgery for operable breast cancer: A 20-year experience at the Marseilles Cancer Institute

    International Nuclear Information System (INIS)

    Amalric, R.; Santamaria, F.; Robert, F.

    1982-01-01

    Since 1960 more than 3000 consecutive patients with operable infiltrating breast carcinoma were treated by radiation therapy with or without primary limited surgery, which usually consisted of local excision. For tumors smaller than or equal to 5 cm the ten-year crude survival rate is 77% for patients without palpable axillary nodes (T/sub 1-2/N 0 ) and 63% for patients having axillary adenopathy (T/sub 1-2/N 1 ). For operable tumors exceeding 5 cm in diameter (T 3 N/sub 0-1/) the ten-year crude survival is 34%. Thirty-five percent of the patients alive free of disease at ten years required a secondary operation for presumed local or regional tumor persistence or recurrence, although no residual disease was found in 24% of the operative specimens. Local-regional recurrence had no adverse effect on ten-year survival. This conservative approach offers most women with operable breast cancer an excellent chance at breast preservation with the same chance for ten-year survival as with radical mastectomy

  10. Beyond ‘Technology for Development’ and ‘Sustainability’ towards systemic and holistic rural innovation: Success factors from the Southern African experience over 20 years

    CSIR Research Space (South Africa)

    Van Rensburg, J

    2014-06-01

    Full Text Available -centred network development that consists of: identifying the key visions (and dreams) as well as innovative systemic dependencies in the targeted context and services delivery channel; developing a programmatic behavioural change process; utilising ICTs...

  11. Long-term biological legacies of herbivore density in a landscape-scale experiment: forest understories reflect past deer density treatments for at least 20 years

    Science.gov (United States)

    Tim Nuttle; Todd E. Ristau; Alejandro A. Royo

    2014-01-01

    Ungulate browsers, when at high densities, are major drivers of vegetation change in forests world-wide. Their effects operate via a variety of generalizable mechanisms related to plant palatability and relative growth rate with respect to browsing pressure. Though such impacts are obviously long-lasting when they determine composition of tree regeneration, we document...

  12. Correction of Pectus Excavatum by Custom-Made Silicone Implants: Contribution of Computer-Aided Design Reconstruction. A 20-Year Experience and 401 Cases.

    Science.gov (United States)

    Chavoin, Jean-Pierre; Grolleau, Jean-Louis; Moreno, Benjamin; Brunello, Jérémie; André, Aymeric; Dahan, Marcel; Garrido, Ignacio; Chaput, Benoit

    2016-05-01

    In the absence of demonstrable functional impairment, pectus excavatum is merely a congenital deformity, albeit with a marked psychological impact. Many patients do not wish to undergo thoracic remodeling operations, which are invasive and do not clearly result in respiratory or cardiac improvement. From 1993 to 2015, the authors designed 401 custom-made silicone implants to treat funnel chests. Before 2007, implants were made from plaster chest molds. Beginning in 2007, three-dimensional reconstructions were made from computed tomographic scans by computer-aided design. The authors prospectively recorded all assessments and follow-up data since 1993. Preoperative and postoperative photographs of two random groups of 50 patients were analyzed, in a blinded manner, by two surgeons independently. Intraoperative and postoperative complications, clinical outcomes, patient satisfaction, and quality of life were evaluated. One infection and three hematomas were recorded. Periprosthetic seroma was evident in all cases. Patients rated the cosmetic outcomes of computer-aided design implants significantly higher than those of the earlier implants made using plaster molds (p = 0.030). Malformations were better corrected in the computer-aided design group (86 percent) than in the plaster group (72 percent) (p = 0.038). Patient satisfaction was higher in the former group (p = 0.011). Medical Outcomes Study 36-Item Short-Form Health Survey scores revealed significant improvements, both socially and emotionally. Correction of pectus excavatum using a computer-aided design silicone implant fulfils aesthetic and psychological demands. The technique is simple and reliable and yields high-quality results. In the medium term, the approach may render invasive techniques obsolete. These operations remain risky and of doubtful functional utility. Therapeutic, III.

  13. The latest technical solutions in rail vehicles drives

    Directory of Open Access Journals (Sweden)

    Andrzejewski Maciej

    2017-01-01

    Full Text Available The article discusses the latest trends and solutions used in the offers of rail vehicles manufacturers. The study is mainly concerned with the technical solutions used in hybrid rail vehicles, whose development has become one of the priorities for the development of rail vehicles in the European Union in recent years. Stricter emissions standards for harmful compounds in the European Union have forced manufacturers to use increasingly sophisticated technology, including hybrid drives and alternative fuels. The products and solutions offered by the major manufacturers on the market, along with their capabilities and future applications are described. The predicted trends in the development of propulsion technology for rail and road-rail vehicles are also indicated in view of the current legislative aspirations among the EU Member States.

  14. Latest-Generation Transcatheter Aortic Valve Replacement Devices and Procedures.

    Science.gov (United States)

    Chamandi, Chekrallah; Puri, Rishi; Rodriguez-Gabella, Tania; Rodés-Cabau, Josep

    2017-09-01

    Transcatheter aortic valve replacement (TAVR) is a well-established treatment for patients with severe symptomatic aortic stenosis who are at high or prohibitive surgical risk. More recently, TAVR has emerged as a valid alternative to surgical aortic valve replacement for treating intermediate-risk patients, and several studies are currently evaluating the role of TAVR in low-risk patients. Transcatheter heart valve (THV) technologies have evolved considerably over time, and important iterations have been implemented in many of the latest-generation devices to (1) reduce the size and improve delivery system properties; (2) improve valve deployment, repositioning, and retrievability; and (3) reduce paravalvular leaks. This article reviews the main characteristics of, and clinical results associated with, the newer-generation THVs while providing an overview of novel TAVR indications. Copyright © 2017 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.

  15. Latest development on the membrane formation for gas separation

    Directory of Open Access Journals (Sweden)

    Ahmad Fausi Ismail

    2002-11-01

    Full Text Available The first scientific observation related to gas separation was encountered by J.K Mitchell in 1831. However, the most remarkable and influential contribution to membrane gas separation technology was the systematic study by Thomas Graham in 1860. However only in 1979, membrane based gas separation technology was available and recognized as one of the most recent and advanced unit operations for gas separation processes. Membrane is fabricated by various methods and the parameters involved to a certain extent are very complicated. The phase inversion technique that is normally employed to produce membranes are dry/wet, wet, dry and thermal induced phase separation. Other techniques used to produce membrane are also reviewed. This paper reports the latest development in membrane formation for gas separation. The route to produce defect-free and ultrathin-skinned asymmetric membrane is also presented that represents the cutting edge technology in membrane gas separation process

  16. The vehicle routing problem latest advances and new challenges

    CERN Document Server

    Golden, Bruce L; Wasil, Edward A

    2008-01-01

    The Vehicle Routing Problem (VRP) has been an especially active and fertile area of research. Over the past five to seven years, there have been numerous technological advances and exciting challenges that are of considerable interest to students, teachers, and researchers. The Vehicle Routing Problem: Latest Advances and New Challenges will focus on a host of significant technical advances that have evolved over the past few years for modeling and solving vehicle routing problems and variants. New approaches for solving VRPs have been developed from important methodological advances. These developments have resulted in faster solution algorithms, more accurate techniques, and an improvement in the ability to solve large-scale, complex problems. The book will systematically examine these recent developments in the VRP and provide the following in a unified and carefully developed presentation: Present novel problems that have arisen in the vehicle routing domain and highlight new challenges for the field; Pre...

  17. The status and latest issues on KAERI export control implementation

    International Nuclear Information System (INIS)

    Kim, Hyun Sook; Park, Ho Jun; Kim, Hyun Jo; Ko, Han Suk; Lee, Byung Doo

    2010-01-01

    There are four informal non-proliferation arrangements which seek to control the proliferation of weapons of mass destruction and their missile delivery systems and the transfer of conventional weapons and dual-use technologies. The four arrangements are Wassenaar Arrangement (WA) on export controls for conventional arms and dual use goods and technologies, Nuclear Supplies Group(NSG), Missile Technology Control Regime(MTCR) and Australia Group(AG) on chemical and biological weapons materials. ROK participates in four arrangements to seek to encourage responsible practice in the trade of strategic goods and technologies. It is achieved through the implementation of export control list. MKE Notification (Ministry of Knowledge Economy Notification No. 2009-250) specifies those items and technologies subject to control. In this paper, the status and latest issues on KAERI export control implementation are described

  18. Constraining viscous dark energy models with the latest cosmological data

    Science.gov (United States)

    Wang, Deng; Yan, Yang-Jie; Meng, Xin-He

    2017-10-01

    Based on the assumption that the dark energy possessing bulk viscosity is homogeneously and isotropically permeated in the universe, we propose three new viscous dark energy (VDE) models to characterize the accelerating universe. By constraining these three models with the latest cosmological observations, we find that they just deviate very slightly from the standard cosmological model and can alleviate effectively the current H_0 tension between the local observation by the Hubble Space Telescope and the global measurement by the Planck Satellite. Interestingly, we conclude that a spatially flat universe in our VDE model with cosmic curvature is still supported by current data, and the scale invariant primordial power spectrum is strongly excluded at least at the 5.5σ confidence level in the three VDE models as the Planck result. We also give the 95% upper limits of the typical bulk viscosity parameter η in the three VDE scenarios.

  19. Constraining viscous dark energy models with the latest cosmological data

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Deng [Nankai University, Theoretical Physics Division, Chern Institute of Mathematics, Tianjin (China); Yan, Yang-Jie; Meng, Xin-He [Nankai University, Department of Physics, Tianjin (China)

    2017-10-15

    Based on the assumption that the dark energy possessing bulk viscosity is homogeneously and isotropically permeated in the universe, we propose three new viscous dark energy (VDE) models to characterize the accelerating universe. By constraining these three models with the latest cosmological observations, we find that they just deviate very slightly from the standard cosmological model and can alleviate effectively the current H{sub 0} tension between the local observation by the Hubble Space Telescope and the global measurement by the Planck Satellite. Interestingly, we conclude that a spatially flat universe in our VDE model with cosmic curvature is still supported by current data, and the scale invariant primordial power spectrum is strongly excluded at least at the 5.5σ confidence level in the three VDE models as the Planck result. We also give the 95% upper limits of the typical bulk viscosity parameter η in the three VDE scenarios. (orig.)

  20. Latest improvements on TRACPWR six-equations thermohydraulic code

    International Nuclear Information System (INIS)

    Rivero, N.; Batuecas, T.; Martinez, R.; Munoz, J.; Lenhardt, G.; Serrano, P.

    1999-01-01

    The paper presents the latest improvements on TRACPWR aimed at adapting the code to present trends on computer platforms, architectures and training requirements as well as extending the scope of the code itself and its applicability to other technologies different from Westinghouse PWR one. Firstly major features of TRACPWR as best estimate and real time simulation code are summed, then the areas where TRACPWR is being improved are presented. These areas comprising: (1) Architecture: integrating TRACPWR and RELAP5 codes, (2) Code scope enhancement: modelling the Mid-Loop operation, (3) Code speed-up: applying parallelization techniques, (4) Code platform downswing: porting to Windows N1 platform, (5) On-line performance: allowing simulation initialisation from a Plant Process Computer, and (6) Code scope extension: using the code for modelling VVER and PHWR technology. (author)