WorldWideScience

Sample records for laser-ad pikaajaline uuring

  1. Uuring : antidepressandid on ohutud

    Index Scriptorium Estoniae

    2007-01-01

    Ohio Columbuse lasteuuringute keskuse ja Pittsburghi Lääne psühhiaatriainstituudi ja -kliiniku teadlaste uuring tõestas, et antidepressantide tarvitajatel ei esine enesetapumõtteid oluliselt rohkem kui mittetarvitajatel ning noored saavad antidepressantidest tõesti abi

  2. Duplicaat 24-uurs voedingen 1994, inname aan zink

    NARCIS (Netherlands)

    Loon JW van; Ooik A van; Ritsema R; LAC

    1997-01-01

    Voor het onderzoek naar de dagelijkse inname aan zink via de voeding, inclusief drank en drinkwater werden 123 duplicaten van 24-uurs voedingen verzameld in de regio Utrecht. Twee groepen vrijwilligers werden geselecteerd die, sociaal en qua leeftijd, een zo getrouw mogelijk beeld vormden van de

  3. Ilmus uus võõrkeelte õpetamise uuring

    Index Scriptorium Estoniae

    2001-01-01

    Üleeuroopaline hariduse infovõrgustik Eurydice European Network on oma järjekordse uuringu pühendanud võõrkeelte õpetamisele. Võrdlev uuring viidi läbi 29 "Socratese" programmiga liitunud Euroopa riigis. Uuringust on ilmunud kokkuvõte, mis sisaldab infot selle kohta, kuidas mingis riigis võõrkeelt õpetatakse, milline on õppekava sisu, kuidas leitakse õpetajaid ning organiseeritakse õpetajakoolitust. Kokkuvõte uuringust on ilmunud raamatuna "Foreign Language Teaching in Schools in Europe".

  4. Duplicaat 24 uurs voedingen 1994 - inname aan calcium, magnesium, barium, strontium en mangaan

    NARCIS (Netherlands)

    Loon JW van; Ooik A van; Ritsema R; LAC

    1998-01-01

    In 1994 zijn 123 duplicaten van 24-uurs voedingen verzameld, gevriesdroogd en nadien onderzocht. Op basis van de analyseresultaten is de dagelijkse inneming aan calcium (Ca), magnesium (Mg), barium (Ba), strontium (Sr) en mangaan (Mn) door evenzovele consumenten van deze voedingen vastgesteld.

  5. Infantile presentation of the mtDNA A3243G tRNA(Leu (UUR)) mutation.

    NARCIS (Netherlands)

    Okhuijsen-Kroes, E.J.; Trijbels, J.M.F.; Sengers, R.C.A.; Mariman, E.C.M.; Heuvel, L.P.W.J. van den; Wendel, U.A.H.; Koch, G.; Smeitink, J.A.M.

    2001-01-01

    Mitochondrial DNA (mtDNA) disorders are clinically very heterogeneous, ranging from single organ involvement to severe multisystem disease. One of the most frequently observed mtDNA mutations is the A-to-G transition at position 3243 of the tRNA(Leu (UUR)) gene. This mutation is often related to

  6. The search for mitochondrial tRNA Leu(UUR) A3243G mutation ...

    African Journals Online (AJOL)

    The study aimed to compare the incidence of the pathogenic point mutation A3243G in the gene tRNALeu(UUR) indicating sub-type 2 diabetes mellitus conducted within the Nigerian population with that reported in other populations. 112 patients diagnosed with type 2 diabetes (T2D) mellitus according to the World Health ...

  7. Fish Community Composition and Habitat Use in the Eg-Uur River System, Mongolia

    Directory of Open Access Journals (Sweden)

    Norman Mercado-Silva

    2008-06-01

    Full Text Available Mongolian rivers and their fi sh communities have suffered severe impacts from anthropogenic activities. However, the remoteness of some systems has allowed for the conservation of unique fi sh faunas, including robust populations of Hucho taimen . Conservation of H. taimen requires understanding the composition and ecology of other fi shes in the community. Using multiple sampling techniques, direct observation, and existing literature, we assessed the composition, relative abundance, and ecological attributes of fi shes in the Eg-Uur watershed (Selenge basin. We collected 6 of 12 species known in the watershed. Phoxinus cf. phoxinus and Lota lota were the most and least abundant species, respectively. We failed to detect H. taimen , indicating low abundance or unknown habitat requirements for juveniles. We compared the effectiveness of different sampling techniques (with electro fi shing producing the highest species richness, constructed length-weight relationships for four species , and identi fi ed ecological attributes (i.e., trophic guild, preferred habitat for resident fi shes.

  8. Dagelijkse opneming van nitraat, nitriet en vluchtige N-nitrosaminen, bepaald via analyse van duplicaat 24-uurs voedingen, bemonsterd in 1984/1985

    NARCIS (Netherlands)

    Ellen G; Egmond E; Sahertian ET

    1988-01-01

    Duplicaten van 24-uurs voedingen van 110 personen, bemonsterd in oktober 1984/maart 1985 werden geanalyseerd op gehalte aan nitraat, nitriet en vluchtige N-nitrosaminen. De gemeten gemiddelde nitraatopneming bedroeg 52 mg NO-3/etmaal, bereik 2-500 mg/etmaal. Nitriet was aantoonbaar, d.w.z.

  9. Cardiac abnormalities in diabetic patients with mutation in the mitochondrial tRNA Leu(UUR)Gene

    International Nuclear Information System (INIS)

    Ueno, Hiroshi; Shiotani, Hideyuki

    1999-01-01

    An A-to-G transition at position 3243 of the mitochondrial DNA is known to be a pathogenic factor for mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS), diabetes and cardiomyopathy. This mutation causes dysfunction of the central nervous system in MELAS. Because the heart, as well as the brain and nervous system, is highly dependent on the energy produced by mitochondrial oxidation, these tissues are more vulnerable to mitochondrial defects. Cardiac abnormalities were assessed in 10 diabetic patients associated with this mutation using echocardiography and 123 I-metaiodobenzylguanidine (MIBG) scintigraphy, and compared with 19 diabetic patients without the mutation. Duration of diabetes, therapy, control of blood glucose and diabetic complications, such as diabetic retinopathy and nephropathy, were not different between the 2 groups. Diabetic patients with the mutation had a significantly thicker interventricular septum (16.8±3.7 vs 11.0±1.6 mm, p 0.05). In conclusion, left ventricular hypertrophy with or without abnormal wall motion and severely reduced MIBG uptake may be characteristic in diabetic patients with a mutation in the mitochondrial tRNA Leu(UUR) gene. (author)

  10. Cardiac abnormalities in diabetic patients with mutation in the mitochondrial tRNA {sup Leu(UUR)}Gene

    Energy Technology Data Exchange (ETDEWEB)

    Ueno, Hiroshi [Hyogo Medical Center for Adults, Akashi (Japan); Shiotani, Hideyuki

    1999-11-01

    An A-to-G transition at position 3243 of the mitochondrial DNA is known to be a pathogenic factor for mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS), diabetes and cardiomyopathy. This mutation causes dysfunction of the central nervous system in MELAS. Because the heart, as well as the brain and nervous system, is highly dependent on the energy produced by mitochondrial oxidation, these tissues are more vulnerable to mitochondrial defects. Cardiac abnormalities were assessed in 10 diabetic patients associated with this mutation using echocardiography and {sup 123}I-metaiodobenzylguanidine (MIBG) scintigraphy, and compared with 19 diabetic patients without the mutation. Duration of diabetes, therapy, control of blood glucose and diabetic complications, such as diabetic retinopathy and nephropathy, were not different between the 2 groups. Diabetic patients with the mutation had a significantly thicker interventricular septum (16.8{+-}3.7 vs 11.0{+-}1.6 mm, p<0.001) than those without the mutation. Fractional shortening was lower in diabetic patients with the mutation than those without it (30.7{+-}7.0 vs 42.5{+-}6.6, p<0.001). MIBG uptake on the delayed MIBG image was significantly lower in diabetic patients with the mutation than in those without the mutation (mean value of the heart to mediastinum ratio: 1.6{+-}0.2 vs 2.0{+-}0.4, p>0.05). In conclusion, left ventricular hypertrophy with or without abnormal wall motion and severely reduced MIBG uptake may be characteristic in diabetic patients with a mutation in the mitochondrial tRNA {sup Leu(UUR)} gene. (author)

  11. A Wide Range of 3243A>G/tRNALeu(UUR) (MELAS) Mutation Loads May Segregate in Offspring through the Female Germline Bottleneck

    Science.gov (United States)

    Pallotti, Francesco; Binelli, Giorgio; Fabbri, Raffaella; Valentino, Maria L.; Vicenti, Rossella; Macciocca, Maria; Cevoli, Sabina; Baruzzi, Agostino; DiMauro, Salvatore; Carelli, Valerio

    2014-01-01

    Segregation of mutant mtDNA in human tissues and through the germline is debated, with no consensus about the nature and size of the bottleneck hypothesized to explain rapid generational shifts in mutant loads. We investigated two maternal lineages with an apparently different inheritance pattern of the same pathogenic mtDNA 3243A>G/tRNALeu(UUR) (MELAS) mutation. We collected blood cells, muscle biopsies, urinary epithelium and hair follicles from 20 individuals, as well as oocytes and an ovarian biopsy from one female mutation carrier, all belonging to the two maternal lineages to assess mutant mtDNA load, and calculated the theoretical germline bottleneck size (number of segregating units). We also evaluated “mother-to-offspring” segregations from the literature, for which heteroplasmy assessment was available in at least three siblings besides the proband. Our results showed that mutation load was prevalent in skeletal muscle and urinary epithelium, whereas in blood cells there was an inverse correlation with age, as previously reported. The histoenzymatic staining of the ovarian biopsy failed to show any cytochrome-c-oxidase defective oocyte. Analysis of four oocytes and one offspring from the same unaffected mother of the first family showed intermediate heteroplasmic mutant loads (10% to 75%), whereas very skewed loads of mutant mtDNA (0% or 81%) were detected in five offspring of another unaffected mother from the second family. Bottleneck size was 89 segregating units for the first mother and 84 for the second. This was remarkably close to 88, the number of “segregating units” in the “mother-to-offspring” segregations retrieved from literature. In conclusion, a wide range of mutant loads may be found in offspring tissues and oocytes, resulting from a similar theoretical bottleneck size. PMID:24805791

  12. Mitochondrial tRNALeu(UUR) C3275T, tRNAGln T4363C and tRNALys A8343G mutations may be associated with PCOS and metabolic syndrome.

    Science.gov (United States)

    Ding, Yu; Xia, Bo-Hou; Zhang, Cai-Juan; Zhuo, Guang-Chao

    2018-02-05

    Polycystic ovary syndrome (PCOS) is a very prevalent endocrine disease affecting reproductive women. Clinically, patients with this disorder are more vulnerable to develop type 2 diabetes mellitus (T2DM), cardiovascular events, as well as metabolic syndrome (MetS). To date, the molecular mechanism underlying PCOS remains largely unknown. Previously, we showed that mitochondrial dysfunction caused by mitochondrial DNA (mtDNA) mutation was an important cause for PCOS. In the current study, we described the clinical and biochemical features of a three-generation pedigree with maternally transmitted MetS, combined with PCOS. A total of three matrilineal relatives exhibited MetS including obesity, high triglyceride (TG) and Hemoglobin A1c (HbA1c) levels, and hypertension. Whereas one patient from the third generation manifestated PCOS. Mutational analysis of the whole mitochondrial genes from the affected individuals identified a set of genetic variations belonging to East Asia haplogroup B4b1c. Among these variants, the homoplasmic C3275T mutation disrupted a highly evolutionary conserved base-pairing (28A-46C) on the variable region of tRNA Leu(UUR) , whereas the T4363C mutation created a new base-pairing (31T-37A) in the anticodon stem of tRNA Gln , furthermore, the A8343G mutation occurred at the very conserved position of tRNA Lys and may result the failure in mitochondrial tRNAs (mt-tRNAs) metabolism. Biochemical analysis revealed the deficiency in mitochondrial functions including lower levels of mitochondrial membrane potential (MMP), ATP production and mtDNA copy number, while a significantly increased reactive oxygen species (ROS) generation was observed in polymononuclear leukocytes (PMNs) from the individuals carrying these mt-tRNA mutations, suggesting that these mutations may cause mitochondrial dysfunction that was responsible for the clinical phenotypes. Taken together, our data indicated that mt-tRNA mutations were associated with MetS and PCOS in this

  13. Valminud on uuring õpetajaametist Euroopas / Marilin Harring

    Index Scriptorium Estoniae

    Harring, Marilin

    2002-01-01

    Hariduse infovõrgustik Eurydice koostas 30 Euroopa riigi andmestiku põhjal uuringu õpetajaametist Euroopas. Materjal ilmub Eurydice Key Topics seerias pealkirjaga "The teaching profession in Europe : profile, trends and concerns. Key Topics, Volume 3"

  14. Eestis toimub esimene vanemaealiste uuring / Merle Paats

    Index Scriptorium Estoniae

    Paats, Merle

    2010-01-01

    18. novembril Eestis alanud SHARE uuringust (Survey of Health, Ageing and Retirement in Europe), mille käigus saadakse ülevaade 50-aastaste ja vanemate elanike tervislikust seisundist ja toimetulekust. Tegemist on rahvusvahelise uuringuga, mida samal ajal korraldavad 19 Euroopa riiki. Eestis korraldab SHARE uuringut Statistikaamet koos sotsiaalministeeriumi, Tallinna Ülikooli, Tervise Arengu Instituudi ning Eesti Gerontoloogia ja Geriaatria Assotsiatsiooniga

  15. Pankrotimenetluse majanduslik efektiivsus : empiiriline uuring / Priit Manavald

    Index Scriptorium Estoniae

    Manavald, Priit, 1955-

    2010-01-01

    Uuringust, mille eesmärgiks oli hinnata, kui palju ressursse kulub Eestis toimuvatele pankrotimenetlustele, kui palju ressursse jaotatakse maksejõuetusmenetluse kaudu ümber ja milline on sellise tegevuse majanduslik kasutegur ja efektiivsus. Kehtivast pankrotimenetluse regulatsioonist

  16. Pikaajaline investor huvitub eelkõige äripinna renditulust / Tanel Veisson

    Index Scriptorium Estoniae

    Veisson, Tanel

    2006-01-01

    Ilmunud ka: Delovõje Vedomosti : Nedvizhimost 13. sept. lk. 15. Äripindade investeeringult teenitav tulu jaguneb kaheks: tegevustulu ja kapitalitulu. Pikaajalisi investoreid huvitab esimene, spekulante seevastu viimane

  17. Ühiskondlik vastutus on pikaajaline investeering / Marjatta Pietilä

    Index Scriptorium Estoniae

    Pietilä, Marjatta

    2004-01-01

    Eesti Noorte Kaubanduskoja president Ardo Reinsalu rõhutab, et ühiskondlik vastutus ei ole sama mis heategevus. Ühiskondlik vastutus arendab win-win olukorda, millest saavad kasu nii vastutust kandev firma kui ka sellega seotud inimesed

  18. Uuring: korruptsioon Eestis väheneb / Gert D. Hankewitz

    Index Scriptorium Estoniae

    Hankewitz, Gert D.

    2006-01-01

    Korruptsioonivastase agentuuri Transparency International avalikustatud andmete kohaselt on Eesti rahvusvahelises korruptsioonitajumise indeksi tabelis 24. kohal. Tabel. Vt. samas: Gruusias suur korruptsioonioht

  19. Uuring : neljandik elanikke ei tea Ilvese tegevusest midagi / Dannar Leitmaa

    Index Scriptorium Estoniae

    Leitmaa, Dannar, 1982-

    2007-01-01

    Uuringufirma Faktum & Ariko korraldatud küsitlusest selgus, et 23 % elanikest ei oska öelda, millega on president Toomas Hendrik Ilves viimase aasta jooksul silma paistnud. Eesti Päevalehe poolt tellitud küsitluse tulemusi kommenteerib politoloog Rein Toomla. Ilmunud ka: Harju Ekspress 16. nov. 2007, lk. 2, pealk.: Presidendi tegevusest ei tea iga neljas eestimaalane midagi (lüh.)

  20. Bestrijdingsmiddelen in duplicaat 24-uurs voedingen. (deelrapport I: organochloorbestrijdingsmiddelen)

    NARCIS (Netherlands)

    Greve; P.A.; Harten; D.C. van; Heusinkveld; H.A.G.; Janssen; G.E.; Verschraagen; C.; Tonkelaar; E.M. den

    1987-01-01

    Twee series duplicaat 24-uursvoedingen, verzameld in resp. oktober 1984 en maart 1985, werden onderzocht op hexachloorbenzeen (HCB), alfa-, beta- en gamma-hexachloorcyclohexaan (HCH's), heptachloor en Beta- epoxide (HEPO), aldrin/dieldrin en het DDT-complex (p,p'-DDE, o,p'-DDT,

  1. Näitus kui publiku-uuring / Margaret Tali

    Index Scriptorium Estoniae

    Tali, Margaret

    2008-01-01

    Eve Kiileri näitus "Muuseumilabor" Tallinna Kunstihoone galeriis 26. IX-19. X. Tutvuda saab Kiasmas, Kumus, Briti Muuseumis, Palais de Tokyos, Hamburger Bahnhofis, Vatikani muuseumis, Veneetsia biennaalil läbi viidud publiku-uuringute tulemustega. Publikuteemaline seminar-ümarlaud 16. X

  2. Het uur der waarheid : over de gevangenschap als literaire ervaring

    NARCIS (Netherlands)

    Asscher, Martinus William Benjamin

    2015-01-01

    What is it like to be imprisoned, to spend months or even years in solitary confinement? Apart from the answers that psychology, criminology of philosophy may hold, the biographical-historical study The Hour of Truth. On Imprisonment as a Literary Experience looks at what answers literature has to

  3. Esimene vanemaealiste uuring Eestis / Merle Paats, Jaana Rahno

    Index Scriptorium Estoniae

    Paats, Merle

    2010-01-01

    Novembris algavast SHARE uuringust (Survey of Health, Ageing and Retirement in Europe), mida korraldatakse 19 Euroopa riigis ning mille sihtrühm on vanemaealised ehk 50-aastased ja vanemad inimesed. Eestis korraldab uuringut statistikaamet koostöös sotsiaalministeeriumi, Tallinna Ülikooli ja Tervise Arengu Instituudiga

  4. Uuring osutab Eesti madalale konkurentsivõimele IT-vallas

    Index Scriptorium Estoniae

    2006-01-01

    Võrgutehnoloogiafirma Cisco Systems'i tellitud ja 31 Ida- ja Lääne-Euroopa riigis läbiviidud uuringu tulemusest, millest selgus, et Eestis kasvab IT-spetsialistide puudujääk. Vt. samas: Skype näeb võimalusi laienemiseks

  5. Euroopa Nõukogu uuring kinnitas kahtlusi CIA salavanglate kohta / Krister Paris

    Index Scriptorium Estoniae

    Paris, Krister, 1977-

    2005-01-01

    Võimalikku salavanglate olemasolu Euroopas uurinud Šveitsi poliitik Dick Marty on seisukohal, et tõenäoliselt väikesed salavanglad olid Euroopas, kuid neis olnud vangid viidi ära kohe pärast meedias esinenud paljastusi. Lisa: Europarlament tahab täit tõde. Vt. samas: Salavanglate skandaali uurimine käib mitmel rindel

  6. Kartulisortide pikaajaline säilitamine in vitro ja säilikute kasutamise võimalused nišitoodeteks / Viive Rosenberg, Katrin Kotkas

    Index Scriptorium Estoniae

    Rosenberg, Viive, 1943-

    2015-01-01

    In vitro säilitamine võimaldab koguda sorte ja rahvaaretisi, neid pikaajaliselt säilitada väliskeskonna mõjutuste eest kaitstuna ning tagab võimaluse säilikuid paljundada ja kasvatada gurmeesortidena turustamiseks

  7. Uuring : 3G vajab läbilöögiks televisiooni / Askur Alas

    Index Scriptorium Estoniae

    Alas, Askur, 1973-

    2004-01-01

    Analysys'i uuringu kohaselt võivad need mobiilsideoperaatorid, kes pakuvad 3G võrgus televisiooni või filmide vaatamise võimalust, olla edukamad kui need, kes piirduvad ainult heli ja tavalise andmeside võimalustega

  8. Mida täiskasvanute oskuste uuring meile näitas? / Aune Valk, Vivika Halapuu

    Index Scriptorium Estoniae

    Valk, Aune, 1972-

    2013-01-01

    Avalikustati rahvusvahelise täiskasvanute oskuste uuringu PIAAC tulemused, mis näitas meie 16-65-aastaste inimeste peamiste infotöötlusoskuste taset nii riigi sees kui ka võrdluses teiste riikidega

  9. Uuring mõtestas usaldust poliitika vastu / Peeter Kreitzberg ; vahendas Argo Ideon

    Index Scriptorium Estoniae

    Kreitzberg, Peeter, 1948-2011

    2001-01-01

    Eesti elanike madal usaldus poliitika vastu ei käi mitte lihtsalt mõne isiku ja partei kohta, vaid hõlmab poliitikat kogu ulatuses, järeldasid sotsiaalteadlased septembris-oktoobris küsitletud tuhande inimese vastuseid analüüsides

  10. Uuring "KPMG Majanduse Pulss 2010" näitab ettevõtjate kerget optimismi

    Index Scriptorium Estoniae

    2010-01-01

    KPMG poolt 2010. aasta aprillis läbiviidud veebipõhisest uuringust, mille käigus küsitleti Eesti juhtivate ettevõtete omanikke ja juhte, kes vastasid majanduskasvu, eurot, pankade käitumist ja ettevõtete igapäevategevust puudutavatele küsimustele. Diagrammid

  11. Die 24 uur groepspraktyk as moontlike oplossing vir die na-ure ...

    African Journals Online (AJOL)

    Background: The formation of 24-hour group practices, which entails the collaboration of different practices, to deliver an after hours service, is an increasing trend in urban private practice. The aim of this study was to measure the acceptablility and efficiency of the 24 hour practice as solution for the after hours dilemma.

  12. WHO uuring: vaesed kulutavad enim ravimitele, jõukad hambaravile / Jarno Habicht ; intervjueerinud Liina Ristoja

    Index Scriptorium Estoniae

    Habicht, Jarno, 1976-

    2010-01-01

    Maailma Terviseorganisatsiooni Eesti esinduse juht räägib Eesti inimeste kulutustest ravimitele ning tervishoiuteenustele, Eesti tervisesüsteemi arengust, tervishoiuteenuste kättesaadavusest ja sissetulekute ning tervishoiuteenuste vahelisest suhest teistes Euroopa Liidu riikides

  13. Uuring : Eesti autostumisel on Lääne-Euroopaga võrreldes palju arenguruumi

    Index Scriptorium Estoniae

    2007-01-01

    Autostumisest Eestis ja Euroopa Liidu liikmesriikides, Euroopa Komisjoni poolt tellitud Eurobaromeetri uuringu tulemustest. Lisa: 2006. aastal esmaregistreeriti Eestis kokku 74 212 sõiduautot, aasta varem 60 626 sõiduautot.

  14. Tuuleenergia prognoosi täpsuse uuring / Teolan Tomson, Maire Hansen, Raimo Pirksaar

    Index Scriptorium Estoniae

    Tomson, Teolan, 1932-

    2004-01-01

    Esimene ekspluatatsioonikogemus näitas, et kohalikes oludes töötavad tuulikud (Virtsus) suhteliselt hästi. Väikesevõimsuselised tuulepargid ei mõjuta Eesti elektrivõrgu tööd, pigem vastupidi. Graafikud. Skeemid. Tabelid. Diagrammid

  15. Värske uuring: tulumaksutagastus aitab igapäevakulusid kanda / Piret Suitsu

    Index Scriptorium Estoniae

    Suitsu, Piret

    2010-01-01

    Swedbanki Eraisikute Rahaasjade Teabekeskuse uuringust selgus, et Eesti elanikud vajavad toimetulekuks tulumaksutagastust. Teabekeskus korraldas ümarlaua, millest võtsid osa ka Eiki Nestor ja Taavi Rõivas. Diagrammid, tabel

  16. Evaluatie snelheidscampagne op 80- en 100-km/uur wegen in Friesland.

    NARCIS (Netherlands)

    Oei, H.-l.

    1996-01-01

    The longer version of this study is published by the SWOV Institute for Road Safety Research, Serial Number R-95-24, see C 3855 (IRRD 875254). In 1994, a speed enforcement campaign was conducted on 39 roads of the provincial network in the Dutch province of Friesland. The whole campaign was

  17. Twee botsproeven op de slipform STEP-barrier : verslag van twee botsproeven, een personenauto bij 100 km/uur en een bus bij 70 km/uur, uitgevoerd door testinstituut LIER in Frankrijk.

    NARCIS (Netherlands)

    Pol, W.H.M. van de

    1996-01-01

    An aim of collision trials on actual scale is to assess whether the developed slipform STEP barrier meets the `higher containment level' H2. The trials required for assessment are TB 11 and TB 51. TB 11 is a test using a light passenger car with a mass of 900 kg, travelling at a speed of 100 km/h

  18. Inherent veilige 80 km/uur-wegen : ontwikkeling van een strategie voor een duurzaam-veilige (her)inrichting van doorgaande 80 km/uur-wegen. Deel I: keuze van de relevante wegen en het opstellen van criteria en eisen.

    NARCIS (Netherlands)

    Minnen, J. van

    1993-01-01

    The former Dienst Verkeerskunde of Rijkswaterstaat commissioned SWOV Institute for Road Safety Research to develop a strategy for an "inherent safe" reconstruction of 80 km/h through roads in the Netherlands. The first part of this study is the conceptualization phase. It classifies 80 km/h through

  19. The m.3291T>C mt-tRNALeu(UUR) mutation is definitely pathogenic and causes multisystem mitochondrial disease

    Science.gov (United States)

    Yarham, John W.; Blakely, Emma L.; Alston, Charlotte L.; Roberts, Mark E.; Ealing, John; Pal, Piyali; Turnbull, Douglass M.; McFarland, Robert; Taylor, Robert W.

    2013-01-01

    Mitochondrial tRNA point mutations are important causes of human disease, and have been associated with a diverse range of clinical phenotypes. Definitively proving the pathogenicity of any given mt-tRNA mutation requires combined molecular, genetic and functional studies. Subsequent evaluation of the mutation using a pathogenicity scoring system is often very helpful in concluding whether or not the mutation is causing disease. Despite several independent reports linking the m.3291T>C mutation to disease in humans, albeit in association with several different phenotypes, its pathogenicity remains controversial. A lack of conclusive functional evidence and an over-emphasis on the poor evolutionary conservation of the affected nucleotide have contributed to this controversy. Here we describe an adult patient who presented with deafness and lipomas and evidence of mitochondrial abnormalities in his muscle biopsy, who harbours the m.3291T > C mutation, providing conclusive evidence of pathogenicity through analysis of mutation segregation with cytochrome c oxidase (COX) deficiency in single muscle fibres, underlining the importance of performing functional studies when assessing pathogenicity. PMID:23273904

  20. Põllumajanduslike väikemajapidamiste struktuuri uuring, 2004 = Structure survey of agricultural small units, 2004 / Eve Valdvee, Andres Klaus

    Index Scriptorium Estoniae

    Valdvee, Eve, 1975-

    2005-01-01

    2004. aastal Statistikaameti korraldatud põllumajanduslike väikemajapidamiste struktuuri uuringu tulemustest. Analüüsi eesmärgiks oli saada andmeid ettevõtete struktuuris toimunud muutustest aastatel 2001-2004. Tabelid. Diagrammid

  1. Evaluatie snelheidscampagne op 80- en 100 km/uur-wegen in Overijssel : rapportage over fase 0, 1 en 2.

    NARCIS (Netherlands)

    Oei, H.-l. & Goldenbeld, C.

    1995-01-01

    In 1994, a speed enforcement campaign was conducted on a two-lane provincial road network in the Dutch province of Overijssel. The campaign was conducted during two phases of around three months each, before and after the summer holidays. Before the start and during the campaign information about

  2. Kaasaegse kunsti muuseum tahab Kalamajja oma maja / Agnes Ojala

    Index Scriptorium Estoniae

    Ojala, Agnes

    2010-01-01

    MTÜ Eesti Kaasaegse Kunsti Muuseum avaldas linnale soovi sõlmida tühjana seisva Tallinna Kütte kontorihoone (Põhja pst. 35) kohta pikaajaline rendileping, et hoone renoveerida ja seal muuseum avada

  3. Juudi sõduri aitas vabadusse sakslaste "härra Hezbollah" / Kadri Veermäe

    Index Scriptorium Estoniae

    Veermäe, Kadri

    2011-01-01

    Iisrael sõlmis Gaza sektorit kontrolliva rühmitusega Hamas leppe, mille raames Iisrael vabastab 1000 Palestiina vangi kui Hamas vabastab 2006. aastal Gaza mässuliste poolt vangistatud Gilad Shaliti. Noore miinipilduri pikaajaline vangistus

  4. Saaremaa sadamate majanduslik-regionaalpoliitiline tähtsus ja arenguperspektiivid / Taavo Asuja, Ain Eidast

    Index Scriptorium Estoniae

    Asuja, Taavo

    2005-01-01

    Et puudub selgus püsiühenduse rajamise ning selle tegevuse suhtes, on raskendatud sadamate arengu pikaajaline prognoosimine ja suunamine. Autorite hinnangul oleks vaja koostada Saaremaa sadamate arengu kontseptsioon. Tabelid. Diagrammid

  5. Kuriteoohvrite kaitse ja kohtlemise uuring : aruande kokkuvõte : [august 2017] / [Kerly Espenberg, Maie Kiisel, Maarika Lukk ... jt. ; Tartu ülikooli sotsiaalteaduslike rakendusuuringute keskus RAKE

    Index Scriptorium Estoniae

    2017-01-01

    Ohvrite direktiivi Eesti õigusse ülevõtmise analüüs, ülevaade kuriteoohvrite õigustest ja nende kasutamisest, ohvrite kohtlemisest menetluses, ohvriabist ja selle pakutavatest teenustest ning hüvitistest, lepitusmenetlusest, asutuste koostööst ja ennetustööst ohvrite kaitsel ning kuriteo mõjust ohvrite igapäevaelule

  6. Evaluatie van het toezicht op snelheid op het 80 km/uur-wegennet in Flevoland : rapportage over fase 0, 1 en 2.

    NARCIS (Netherlands)

    Oei, H.-l. & Goldenbeld, C.

    1995-01-01

    In 1994, a speed campaign was conducted on 80 km/h roads in the Noord and Midden police districts in the Dutch province of Flevoland. This campaign was held before and after the summer holidays. In the Noord district, speed enforcement was carried out by using radar and a camera exclusively, and a

  7. Uuring: kulude kärpimine jätkub / Urve Vilk ; kommenteerinud Jaan Rosenthal, Jaan Meikup, Piret Uudeküll ... [jt.

    Index Scriptorium Estoniae

    Vilk, Urve

    2009-01-01

    KPMG korraldatud ülemaailmne finantsjuhtide küsitlus näitas, et vaatamata juba tehtud kärbetele plaanivad organisatsioonid lähiaastatel kulusid veel kuni 25 protsendi ulatuses vähendada. Juba tehtud ja plaanitavaid kulude kärpeid kommenteerivad Eesti ettevõtete juhid

  8. Non-market value of Estonian seminatural grasslands: a contingent valuation study. Eesti poolloodusliku rohumaa turuväline väärtus: tingliku hindamise uuring

    Directory of Open Access Journals (Sweden)

    Helli Lepasaar

    2015-12-01

    Full Text Available Seminatural grasslands i.e. the floodplain meadows, seashore meadows, wooded meadows, dry meadows, wooded pastures are the very traditional part of Estonian landscapes, which play an important role in the appearance of the landscape in general and also serve as an important habitat for many plant and animal species. In order to preserve the seminatural grasslands continuous annual mowing and/or pasturing is needed. This activity is not economically profitable and needs subsidizing. The authors of the work raise a hypothesis that the Estonian seminatural grasslands could be viewed as a valuable non-market environmental good for which a significant public demand exists. In order to find out the non-market value of the seminatural grasslands a contingent valuation study was carried out among the Estonian working-age population (size of the sample 1061 individuals. The average individual willingness to pay was 11.3 euros. During the study, the authors constructed the total demand function and discovered that the total annual demand for seminatural grasslands was 17.9 million euros.

  9. Snelheidsbeheersing op 50 km/uur-wegen. Bijdrage aan `Gemeente-info' van september/oktbober 1995, met betrekking tot het speerpunt `Aangepaste snelheden'.

    NARCIS (Netherlands)

    Catshoek, J.W.D.

    1996-01-01

    In this report, speed control on 50 km/h roads in the Netherlands is dealt with. The report includes the following: a description of the speed problem; an explanation of the importance of structural measurements (monitoring) of driving speeds on main roads; a design for simple speed measurements;

  10. Evaluatie van het toezicht op snelheid op 80- en 100 km/uur-wegen in Friesland : rapportage over fase 0, 1 en 2.

    NARCIS (Netherlands)

    Oei, H.-l. & Goldenbeld, C.

    1995-01-01

    In 1994, a speed enforcement campaign was conducted on 39 roads of the provincial network in the Dutch province of Friesland. The whole campaign was conducted during two phases: three months before and three months after the summer holidays. Before the start and during the campaign information about

  11. Effecten van inrichting tot 30 km/uur zone in 15 experimentele gebieden : een evaluatiestudie op basis van integratie van resultaten uit verkeerskundige studies, bewonersonderzoeken en een ongevallenanalyse.

    NARCIS (Netherlands)

    Vis, A.A.

    1992-01-01

    Dutch municipal authorities have been able to institute a maximum speed of 30 km/h roads in zones within built-up areas, since the year 1984. The safety effects of 30 km/h zones are positive. In order to be sure about this, the Ministry of Transport and Public Works has encouraged 15 municipalities

  12. Risicofactoren op 50km/uur-kruispunten met verkeerslichten : methodologische verdieping en verdere verkenning van de kwantificering van risicofactoren zoals roodlichtnegatie.

    NARCIS (Netherlands)

    Aarts, L.T. Loenis, B. Korving, H. & Guiking, C.

    2018-01-01

    Risk factors at 50 km/h intersections with traffic lights : methodological follow-up and further exploration of the quantification of risk factors such as red light runningrunning. In 2016, SWOV investigated risk factors in traffic. These risk factors are also known as Safety Performance Indicators

  13. Kellele ema kellele tütar. Bain & Co uuring : kuus järeldust töötegemise vahendite kohta / Vello Rääk

    Index Scriptorium Estoniae

    Rääk, Vello

    2005-01-01

    Rahvusvahelise konsultatsioonifirma Bain & Co poolt läbi viidud uuringust, mille käigus selgitati välja, milliseid juhtimise tööriistu firmad kasutavad. 2005. aasta uuringu kuuest põhijäreldusest. Graafikud

  14. Twee botsproeven op de verankerde stalen STEP-barrier : verslag van twee botsproeven, een personenauto met 100 km/uur en 20 graden inrijhoek en een bus met 70 km/uur en 20 graden inrijhoek, op de verankerde STEP-barrier, uitgevoerd door testinstituut LIER in Frankrijk. In opdracht van het Directoraat-Generaal Rijkswaterstaat, Adviesdienst Verkeer en Vervoer AVV.

    NARCIS (Netherlands)

    Pol, W.H.M. van de

    1996-01-01

    An aim of collision trials on actual scale is to assess whether the developed anchored steel STEP barrier meets the `higher containment level' H2. The trials required for assessment are TB 11 and TB 51. TB 11 is a test using a light passenger car with a mass of 900 kg. TB 51 is a test using a bus

  15. Briti ekspert : euroliidus kaob Eestist tööpuudus / Michael Richardson ; interv. Airi Ilisson

    Index Scriptorium Estoniae

    Richardson, Michael

    2003-01-01

    Eestis Suurbritannia tööreformi tutvustava töö- ja sotsiaalnõuniku sõnul on Suurbritannias peaaegu kadunud pikaajaline töötus noorte hulgas, vanematest inimestest on vaid üksikud tööta kauem kui aasta. Vt. samas: Kes on Michael Richardson?

  16. Olympic - Eesti esimene maailmavallutaja? / Tarvo Vaarmets

    Index Scriptorium Estoniae

    Vaarmets, Tarvo

    2008-01-01

    Olympic on väga tugeva juhiga, ambitsioonikas ettevõte, mille aktsia hind on kukkunud tasemele, mida võiks pikaajaline investor tasapisi hakata võtma kui head ostukohta. Vt. samas: Tugevad näitajad sisendavad kindlust. Diagramm: Olympicu aktsia

  17. Doonorfond on vaesuse, mitte Iraagi pärast / Jeffrey D. Sachs

    Index Scriptorium Estoniae

    Sachs, Jeffrey D.

    2003-01-01

    Autor leiab, et Iraagi pikaajaline ülesehitamine ei vaja finantsabi välismaalt, vaid poliitilist reguleerimist, mis pole võimalik niikaua, kui USA jääb Iraagis okupatsioonijõuks. USA taotletav raha tuleks aga suunata ülemaailmsete hädade, nagu AIDS ja nälg, vastu võitlemiseks.

  18. Kas U, V või W? Ei, hoopis Ч / Alar Tamming

    Index Scriptorium Estoniae

    Tamming, Alar

    2010-01-01

    Autor kirjutab, et kuna käesolevast majanduskriisist on haaratud kogu maailm, võib kriis kujuneda tagurpidi h-kujuliseks: majanduslangus lõpeb näilise majanduskasvuga, millele aga järgneb uus sügav pikaajaline langus

  19. Alaealiste hälbekäitumine Eestis, Tšehhis ja Ungaris : rahvusvaheline self-report-meetodil tehtud delinkventsuse uuring (ISRD-2) / Anna Markina, Jüri Saar

    Index Scriptorium Estoniae

    Markina, Anna, 1966-

    2009-01-01

    Uuringust International Self-Report Delinquency Study-2 (ISRD-2) alaealiste hälbiva käitumise hindamiseks. Delinkventsuse, riskikäitumise, õigusrikkumiste või koolivägivalla ohvriks langemise tasemest Eestis, Tšehhis ja Ungaris. Tabelid

  20. De veiligheid van voetgangers en fietsers op 30km/uur-erftoegangswegen : de invloed van de inrichting van erftoegangswegen binnen de bebouwde kom op ongevallen tussen langzaam verkeer en motorvoertuigen.

    NARCIS (Netherlands)

    Berends, E.M. & Stipdonk, H.L.

    2009-01-01

    During the past ten years many residential roads in the Netherlands have been converted from 50 km/h roads into 30 km/h roads. The guidelines for 30 km/h access roads describe the road design and the traffic rules for roads where car traffic is allowed, but where children should also be able to play

  1. Problema ne v korruptsii, no v jevrobjurokratii / Dmitri Kulikov

    Index Scriptorium Estoniae

    Kulikov, Dmitri

    2005-01-01

    Eesti korrumpeerumise madal tase - 31. koht 145 riigi seas organisatsiooni Transparency International aruandes - tagab riigi konkurentsivõime ning välisinvestorite huvi. Konjunktuuriinstituudi uuring suhtumisest korruptsiooni

  2. Reaalse vahetuskursi hälbe mõjud Eestis / Meelis Angerma, Mart Sõrg

    Index Scriptorium Estoniae

    Angerma, Meelis

    2003-01-01

    Eesti reaalse vahetuskursi uuring näitas, et reaalne tasakaaluline vahetuskurss on oluliselt tõusnud. See vastab teoreetilistele ootustele, et majanduskasvuga kaasneb reaalkursi kallinemine. Tabelid. Graafikud

  3. Evidence that the mitochondrial leucyl tRNA synthetase (LARS2) gene represents a novel type 2 diabetes susceptibility gene

    NARCIS (Netherlands)

    L.M. 't Hart (Leen); H.A.P. Pols (Huib); T. Hansen (Torben); I. Rietveld (Ingrid); J.M. Dekker (Jacqueline); J.A. Maassen (Johannes); M.G.A.A.M. Nijpels (Giel); G.M.C. Janssen (George); P.P. Arp (Pascal); R.J. Heine (Robert); A.G. Uitterlinden (André); T. Jorgensen (Torben); C.M. van Duijn (Cornelia); K. Borch-Johnsen; O. Pedersen (Oluf)

    2005-01-01

    textabstractPreviously, we have shown that a mutation in the mitochondrial DNA-encoded tRNA(Leu(UUR)) gene is associated with type 2 diabetes. One of the consequences of this mutation is a reduced aminoacylation of tRNA(Leu(UUR)). In this study, we have examined whether variants in the leucyl tRNA

  4. Evaluatie terugbrengen sluitingstijden coffeeshops Rotterdam

    NARCIS (Netherlands)

    Korf, D.J.; Liebregts, N.

    2015-01-01

    Vanaf oktober 2013 heeft de gemeente Rot-terdam in de loop van ongeveer een jaar de sluitingstijd van de meeste van de 40 coffee-shops vervroegd van 24:00 uur naar 22:00 uur, met uitzondering van 7 coffeeshops in het centrum. Onderzocht is welke gevolgen deze maatregel had voor de overlast,

  5. Dertig dagen zonder televisie: mogelijkheden te over

    NARCIS (Netherlands)

    Peters, K.B.M.; Rijnierse, J.

    2007-01-01

    Van kinderen in de leeftijd van 4-11 jaar kijkt bijna 60% meer dan 9 uur televisie per week. Nederlandse kinderen kijken gemiddeld 2 uur per dag naar de televisie. Het feit dat kinderen televisie kijken, krijgt veel aandacht vanwege de negatieve gevolgen die dit zou hebben op de ontwikkeling van

  6. Eesti keskkonnamõju hindamise süsteemi efektiivsuse mõõtmine = The evaluation of effectivness of Estonian environmental impact assessment system : II koht magistritööde kategoorias / Kaupo Heinma

    Index Scriptorium Estoniae

    Heinma, Kaupo

    2009-01-01

    Artikli aluseks olevas magistritöös määrati keskkonnamõju hindamise süsteemi efektiivsus ja selle mõõtmine. Uuringu käigus viidi läbi Harju maakonda hõlmav pilootala uuring, seejärel täiendav üle-eestiline uuring olulisima mõjuteguri selgitamiseks

  7. P.J. Ie Roux·

    African Journals Online (AJOL)

    Ses groepe van 45 volwasse Karakoelooie is met 40 mg MAP sponse vir 15 dae behandel. Vyf van die groepe het 400 IE DMS twee dae voor sponsonttrekking ontvang. AI die ooie is gepaar 12 uur na aanvang van oestrus en weer 9 tot 10 uur later. ofkunsmatig. Of deur middel van natuurlike paring. Een van die groepe is ...

  8. Nafta hinna tõusuks leidub põhjusi / Romet Kreek

    Index Scriptorium Estoniae

    Kreek, Romet, 1972-

    2004-01-01

    Autori hinnangul on nafta hinnatõusu peamiseks põhjuseks pikaajaline nafta pakkumise allajäämine nõudlusele kasvava rahuldamata nõudluse tingimustes, mida toetab omakorda piiratud naftatöötlemisvõimsus ja kasvavad tootmiskulud. Diagrammid: Maailma naftatoodang jääb tarbimisele alla; 10 suurimat toodavad 63,5% naftast; Suurim naftatarbija on USA. Vt. samas: Kellele müüa naftat?

  9. Eesti sotsiaaluuringu palgaandmete ühilduvus Maksu- ja Tolliameti andmetega = Compatibility of the wages and salaries data recorded in the Estonian Social Survey and Estonian Tax and Customs Board database / Piia-Piret Eomois

    Index Scriptorium Estoniae

    Eomois, Piia-Piret

    2007-01-01

    Eesti sotsiaaluuring (ESU) on Euroopas rahvusvaheliselt harmoneeritud uuring sissetuleku ja vaesuse mõõtmiseks. Analüüs uurib võimalikku üleminekut Maksu- ja Tolliameti andmebaasi sissetulekuandmete kasutamisele ESU-s. Tabelid. Diagrammid

  10. Explaining cross-national variations in the informalisation of employment. Some lessons from Central and Eastern Europe / Colin C. Williams

    Index Scriptorium Estoniae

    Williams, Colin C.

    2015-01-01

    Kesk- ja Ida-Euroopa (sh Eesti) riikide vahelistest erinevustest mitteametlikus tööhõive kolmest teoreetilisest seisukohast (moderniseerimine, neoliberaalne, poliitiline ökonoomia) lähtuvalt, aluseks 2007. aasta Eurobaromeetri uuring.

  11. Optimal alcohol taxation: Simulation results for Estonia / Indrek Saar

    Index Scriptorium Estoniae

    Saar, Indrek, 1978-

    2011-01-01

    Uuring analüüsib optimaalset alkoholi maksustamist Eestis erinevate mõjutegurite ja rahanduspoliitika taustal. Tasakaalustatud mudel peab arvestama mitme parameetriga, sealhulgas alkoholitarvitamise negatiivse mõjuga

  12. Meediareklaamiturg kasvab aasta lõpuks kuni kaheksa protsenti / Esta Kaal

    Index Scriptorium Estoniae

    Kaal, Esta, 1962-

    2002-01-01

    Emori uuring: tänu valimistele ja pensionikindlustuse reklaamikampaaniatele on oodata aasta lõpuks kuni 8%-list reklaamituru kasvu. Diagramm. Kommenteerivad Toomas Leito, Toomas Vara ja Marek Reinaas

  13. Onderzoek naar de stabiliteit van reconstitutie van RIVM-humaan juistheidscontroleserum voor enzymactiviteitsmetingen

    NARCIS (Netherlands)

    Steentjes; G.M.; Laar; E.A.van; Buitenhuis; S.G.; Koedam; J.C.

    1984-01-01

    Van het RIVM humaan juistheidscontroleserum voor enzymactiviteitsmethingen is de stabiliteit na reconsitutie gedurende een week bij diverse bewaaromstandigheden onderzocht. Bij normale gebruiksomstandigheden werden na 24 uur geen afwijkingen geconstateerd. Door bacteriele besmetting

  14. Üleminek riigikeelsele gümnaasiumiõppele : vilistlaste seisukohtade Q-metodoloogiline diskursusanalüüs / Anu Masso, Katrin Kello, Valeria Jakobson

    Index Scriptorium Estoniae

    Masso, Anu, 1977-

    2013-01-01

    Keskendutakse diskursustele, mis on seotud riigikeelsele gümnaasiumiõppele üleminekuga senistes vene õppekeelega koolides. Uuring põhineb Tallinnas, Tartus, Ida-Virumaal ja Lätis läbi viidud Q-metodoloogilistel intervjuudel

  15. Laste seksuaalne väärkohtlemine kui moraalipaanika tekitaja : [magistritöö] / Sirli Urvet ; Tartu Ülikool, õigusteaduskond ; juhendaja: Silvia Kaugia

    Index Scriptorium Estoniae

    Urvet, Sirli, 1987-

    2014-01-01

    Pedofiiliast ja laste seksuaalse väärkohtlemise mõistest, moraalipaanika olemusest ja selle tekkimise põhjustest, laste seksuaalne väärkohtlemine kui moraalipaanika tekitaja Eestis: empiiriline uuring

  16. Voters shrug off upcoming EP ballot / Aleksei Gunter

    Index Scriptorium Estoniae

    Gunter, Aleksei, 1979-

    2004-01-01

    Emor'i uuring näitab, et europarlamendi valimistel osaleb kõigest 33 protsenti valijatest ning valik toimub isikute, mitte erakondade järgi. Soosikuteks ennustatakse Toomas Hendrik Ilvest ning Reformierakonda. Tabel

  17. Kas Eesti peaks makse tõstma? Teised vähendavad... / Ranno Tingas

    Index Scriptorium Estoniae

    Tingas, Ranno, 1976-

    2009-01-01

    Konsultatsiooni- ja audiitorbüroo Ernst & Young 2009. aasta uuringust, milles vaadeldi 24 riigi maksupoliitika muudatusi tulenevalt globaalsest finantskriisist. Uuring kättesaadav: www.ey.com/stimulus

  18. Altijd wat te doen bij het sluisje van Dorkwerd

    NARCIS (Netherlands)

    den Hollander, Franciscus; van Dam, Vanessa; Langenberg, Sjaak

    2006-01-01

    Ooggetuigeverslagen van 84 Nederlandse auteurs die op 1 september 2006 van 11.00 tot 17.00 uur langs de 118 kilometer lange vaarroute van Lemmer naar Delfzijl (Prinses Margrietkanaal, Van Starkenborg-kanaal, Eemskanaal) zaten.

  19. Venemaa ettevõtetest 15 protsenti huvitub Eestist

    Index Scriptorium Estoniae

    2008-01-01

    KPMG Internationali tellitud uuring näitab, et viie aasta pärast tehakse kõige rohkem välisinvesteeringuid Hiinasse. Eestisse investeerimisest huvituvad aga ennekõike Venemaa ja Hispaania ettevõtted

  20. Suurkiskja- ja kotkakahju ennetamise meetmed Eesti ja Soome saartel ning rannikualadel / T. Otstavel

    Index Scriptorium Estoniae

    Otstavel, Teet, 1964-

    2013-01-01

    Uuring käsitleb Eesti ja Soome rannikualade ja saarte loomakasvatajate võimalusi suurendada karjamaadel kaitset suurkiskjate ja merikotkaste vastu ning kasutada suurkiskjate rünnakute ennetamise meetmeid, eelkõige karjavalvekoeri

  1. Milleks mulle paremad oskused? : "Tean ja oskan" uuringu taustast / Vivika Halapuu

    Index Scriptorium Estoniae

    Halapuu, Vivika

    2011-01-01

    Rahvusvaheline täiskasvanute oskuste uuring PIAAC, mille Eesti vaste on "Tean ja oskan", uurib 16-65-aastaste inimeste võtmeoskusi, mis on vajalikud 21. sajandi ühiskonnas ja majanduses toimetulekuks

  2. Sotsiaalne vastutus Eesti moodi : firma maksab, omanik võtab aupaiste? / Külliki Tafel, Ruth Alas

    Index Scriptorium Estoniae

    Tafel, Külliki

    2006-01-01

    Väljavõtteid intervjuudest, mis viidi läbi Estonian Business Schooli ja Tuleviku-uuringute Instituudi poolt korraldatud sotsiaalse vastutuse uuringu raames. Lisa: EBSi ja Tuleviku-uuringute Instituudi uuring

  3. Allergiahaigustest Eesti koolilastel / Triine Annus

    Index Scriptorium Estoniae

    Annus, Triine, 1966-

    2006-01-01

    Aastatel 1993-2002 korraldati Tallinna kooliõpilaste seas kolmeetapiline epidemioloogiline uuring, mille eesmärgiks oli hinnata allergiahaiguste levimust, sh erinevusi võrdluses Rootsi lastega, ajalisi suundumusi ja riskitegureid

  4. PA de Villiers A. Smith Melkwinningis 'n arbllidsintensieweproses en ...

    African Journals Online (AJOL)

    Die invloed van melkintervalle op melk-, bottervet- en proteienproduksie en bottervet-, proteien- en natriumkonsentrasie. Verandering in: Melkproduksie. Bottervet-. Proteitm-. Bottervet-. Proteiim-. Natrium- produksie produksie konsentrasie konsentrasie konsentrasie. A.g.v. toenemende melk- intervalle van: 12 tot 16 uur.

  5. Empathy and objectivity in the legal procedure: the case of Swedish prosecutors / Åsa Wettergren, Stina Bergman Blix

    Index Scriptorium Estoniae

    Wettergren, Åsa

    2016-01-01

    Empaatia rollist ja võimest lugeda teise isiku emotsioone kriminaalmenetluses. Uuring Rootsi prokuröride empaatiavõimest kriminaalmenetluses, selle tähtsusest kohtuistungi ettevalmistamisel ja tõendusmaterjali kogumisel

  6. Õlu, Autobahn, Hitler ja saksa keel Eestis / Heiko F. Martens, Maris Saagpakk

    Index Scriptorium Estoniae

    Martens, Heiko F.

    2013-01-01

    Saksa keele õppijate osakaalu langusest Eestis. Aastail 2011-2012 korraldati kolmes Balti riigis uuring, selgitamaks asjaolusid, mis mängivad rolli saksa keele õppimise poolt või vastu otsustamisel

  7. Ettevõtjad valmis Maad päästma / Teet Tender

    Index Scriptorium Estoniae

    Tender, Teet, 1972-

    2010-01-01

    PricewaterhouseCoopersi uuring "Appetite for change: Global business perspectives on tax and regulation for a low carbon economy" näitas, et ettevõtjad tunnevad vastutust ja soovivad kliima soojenemise peatamise protsessis osaleda

  8. Duplicate 24-hour diet study 1994 organochlorine and organophosphorous pesticides

    NARCIS (Netherlands)

    Baumann RA; Hoogerbrugge R; van Zoonen P; LOC

    1999-01-01

    In 1994 namen 123 respondenten deel aan een duplicaat 24-uurs voedingsonderzoek. De verzamelde duplicaat voeding monsters werden geanalyseerd op macro parameters, nutrieten, mineralen, sporenelementen en contaminanten. Bij aanvang van het onderzoek werd een inschatting gemaakt of de aanwezigheid

  9. Economic strain and perceptions of social cohesion in Europe: does institutional trust matter? / Rhys Andrews, Sebastian Jilke, Steven van de Walle

    Index Scriptorium Estoniae

    Andrews, Rhys

    2014-01-01

    Artikkel analüüsib, kuidas eurooplased tajuvad sotsiaalset ühtekuuluvust, võttes sealjuures arvesse majandussurvet ja institutsionaalset usaldust. Aluseks on Eurobaromeetri uuring vaesusest ja sotsiaalsest tõrjutusest (2010), mis haaras 27 liikmesriiki (sh Eesti)

  10. Taastuvate energiaallikate kasutamist soodustavad ja pidurdavad faktorid Euroopa Liidu uutes liikmesriikides / Ülo Rudi

    Index Scriptorium Estoniae

    Rudi, Ülo

    2007-01-01

    Eesti osalemisest Euroopa Liidu V Raamprogrammi projektis "Energiapoliitika analüüs taastuvate energiaallikate rakendamisel ja energiatootmise tõhususe suurendamisel Euroopa Liidu kandidaatriikides". Uuring tehti aastate 1992-2004 kohta. Lisatud statistilised tabelid

  11. Autolammutuskojad Eestis / Aivi Aolaid, Jüri Teder

    Index Scriptorium Estoniae

    Aolaid, Aivi

    2005-01-01

    Keskkonnaministeeriumi tellimusel valmis PIC Eesti AS-il uuring "Eesi autolammutuskodade kaardistamine", mille eesmärgiks oli välja selgitada autolammutuskodade keskkonnaseisund 2004. aasta suve lõpus. Tabel: Autolammutuskojad maakondade kaupa

  12. Report: Paksas scandal raises privacy concerns / Steven Paulikas

    Index Scriptorium Estoniae

    Paulikas, Steven

    2004-01-01

    Inimõiguste ekspertide uuring näitab, et nii Leedu presidendi Rolandas Paksase administratsiooni töötajad, presidendi tegevuse uurijad kui ka Leedu ajakirjandus rikkusid mitmeid inimõigusi, eelkõige aga õigust privaatsusele

  13. Inimesed linnas = People in the city / Kaja Pae

    Index Scriptorium Estoniae

    Pae, Kaja

    2006-01-01

    Eesti näitus "Joint Space" Veneetsia 10. arhitektuuribiennaalil. AB Urban Mark: Ülar Mark, Indrek Tiigi, Kaja Pae, Yoko Alender, Raul Kalvo, Tartu Ülikooli Geograafiainstituut: Rein Ahas, Anto Aasa, Siiri Silm, Positium ICT: Margus Tiru, Erki Saluveer. Näitusel oli eksponeeritud kolm mobiilpositsioneerimisega läbi viidud case study (EKA liikmete liikumisuuring, Eestit külastanud turistide uuring, Tallinna regiooni pendelrändajate uuring). Bibliograafia lk. 33

  14. Naar een verkeersmeetnet ten behoeve van landelijk en provinciaal beleid : Project Monitoring rijsnelheden op 80- en 100 km/uur-wegen Fase 4 : voorstellen voor de selectie van meetlocaties, criteria voor meetapparatuur en analyse en gebruik van meetgegevens op basis van ervaringen in de provincie Friesland, Overijssel en Limburg en een voorbeeld van een werkwijze om te komen tot een steekproeftrekking.

    NARCIS (Netherlands)

    Oei, H.-l.

    1995-01-01

    This report presents a design for a traffic measuring network for national and provincial purposes. This is made in cooperation with the Dutch provinces of Friesland, Overijssel, and Limburg. A traffic measuring system can be distinguished into a permanent and a temporary system. The first system

  15. Euroopa püüab toime tulla idatööliste marsiga läände / Sarah Laitner, Stefan Wagstyl

    Index Scriptorium Estoniae

    Laitner, Sarah

    2006-01-01

    Mitmed EL-i nn. vanad riigid kõhklevad, kas kaotada piirangud Ida-Euroopa tööjõule. Briti valitsuse väitel on riigi majandus tööturu piirangu kaotamisest kasu saanud, samas on suurenenud noorte pikaajaline töötus. Ida-Euroopas on aga mõnes valdkonnas tekkinud tööjõupuudus. Lisa: Iiri pelgab olukorda tööjõuturul. Tabel: Riikide suhtumine tööjõu vaba liikumise piirangutesse

  16. Oorlewing van die skerpioen Opistophthalmus pugnax (Scorpionidae ná blootstelling aan ’n letale dosis SO2-gas

    Directory of Open Access Journals (Sweden)

    Willie J. van Aardt

    2013-02-01

    Full Text Available Skerpioene is bekend vir hul aanpasbaarheid by toestande in ’n droë habitat, min voedsel en radioaktiewe bestraling. Niks is bekend oor hul aanpasbaarheid by skadelike gasse nie. Resultate van hierdie eksperiment by Opistophthalmus pugnax bewys dat hulle ’n hoë dosis van 1000 dele per miljoen SO2 kan oorleef wat nie die geval is by die mens nie. Byvoorbeeld, die suurstofverbruikskoers neem eerder toe van 4.16 µmol/g-1 uur-1 na 7.69 µmol/g-1uur-1, een uur ná blootstelling aan SO2. Veertig minute na blootstelling was die ṀO2 steeds bykans twee keer hoër in vergelyking met die ṀO2 aan die begin. Hierdie bevinding moet deur verdere eksperimente nagevors word, veral wat die rol van spirakulumsluiting speel by blootstelling aan SO2.

  17. A matter of degree: the continuing training gap for women in Europe / Caroline Wozny, Martin R. Schneider

    Index Scriptorium Estoniae

    Wozny, Caroline

    2014-01-01

    Artikli teemaks on soolõhe koolituses Euroopas, täpsemalt naiste väiksem osalemine tööga seotud koolitustes, aluseks 22 riigis (sh Eesti) ajavahemikul 2005-2008 läbi viidud täiskasvanute koolituse uuring

  18. Loomkatsed ei ole ainuke võimalus / Jeremy Rifkin

    Index Scriptorium Estoniae

    Rifkin, Jeremy

    2007-01-01

    Üks maailma mainekamaid teadusühendusi, USA teadusakadeemia riiklik teadusnõukogu teavitas uuringust "Toksilisuse katsed 21. sajandil: visioon ja strateegia". Uuring teatab, et avastused võivad asendada senise täielikult loomkatsetel põhineva toksilisuse testimise katseklaasi-meetoditega, mis eelistavad kasutada inimpäritolu rakke, rakuliine ja rakukomponente

  19. Parimatest parimad selguvad Tartus / Mariann Märtsin

    Index Scriptorium Estoniae

    Märtsin, Mariann

    2004-01-01

    Rahvusvahelise konsultatsioonifirma Hewitt Associates uuringust "Parimad tööandjad - parimad tulemused" (Best Employers - Best Results). Lisa: Uuring. Raivo Hellerma, Piret Põldre, Milvi Tepp vastavad küsimusele, miks nad osalesid tööandjate uuringus. Vt. samas: Uuringus osalesid

  20. Riiklik integratsiooniprogramm : ametilikud hinnangud ja avaliku arvamuse monitooring / Klara Hallik

    Index Scriptorium Estoniae

    Hallik, Klara

    2003-01-01

    Ilmunud ka: Baltiiskije dilemmõ : võstuplenija po voprossam etnopolitiki ja The Baltic dilemmas : seminar presentations on ethnic policies. Uuringust järeldub, et eestimaalased väärtustavad kõrgelt sotsiaalset võrdsust. Kui ebavõrdsust teadvustatakse rahvusliku ebavõrdsusena (mida uuring näitab), on see konfliktiohtlik ja ühiskonda destabiliseeriv. Tabelid

  1. Euroopa parim tööandja on Eestis / Agne Narusk

    Index Scriptorium Estoniae

    Narusk, Agne, 1971-

    2004-01-01

    Rahvusvahelise konsultatsioonifirma Hewitt Associates korraldas üleeuroopalise uuringu "Parimad tööandjad - parimad tulemused", mille võitis TNT Express Worldwide Eesti AS. Lisa: Euroopa parimate tööandjate Top 15. Eesti parimad tööandjad. Parima tööandja uuring

  2. Eesti tööandja hoiab ELis kõige rohkem töötajate pealt kokku / Kaire Uusen

    Index Scriptorium Estoniae

    Uusen, Kaire

    2005-01-01

    Rahvusvahelise uuringufirma Mercer Human Resources Consulting uuring näitas, et Eesti tööandaja vabatahtlikud kulud töötajatele on ainult 0,7% kõigist kuludest. Diagramm: Kui palju maksab Eesti töötaja?

  3. Důl Jeroným v Čisté - minulost, současnost, budoucnost

    Czech Academy of Sciences Publication Activity Database

    Kukutsch, Radovan; Žůrek, P.; Tomíček, R.

    2010-01-01

    Roč. 2, č. 2 (2010), s. 63-69 ISSN 1212-0855 R&D Projects: GA ČR GA105/09/0089 Institutional research plan: CEZ:AV0Z30860518 Keywords : Jeroným mine * Mining * Heritage Preservation Subject RIV: AP - Urban, Regional and Transport Planning http://www.uur.cz/default.asp?ID=3714

  4. The physics of big sample instrumental neutron activation analysis

    NARCIS (Netherlands)

    Overwater, R.M.W.

    1994-01-01

    Proefschrift ter verkrijging van de graad van doctor aan de Technische Universiteit Delft, op gezag van de Rector Magnificus Prof.ir. K.F. Wakker, in het openbaar te verdedigen ten overstaan van een commissie, door het College van Dekanen aangewezen, op maandag 14 november 1994 te 16.00 uur.

  5. Eestlane kogeb õnne planeedi arvel / Liisi Poll

    Index Scriptorium Estoniae

    Poll, Liisi, 1980-

    2006-01-01

    Ühenduste New Economics Foundation (nef) ja Friends of Earth (FoE) tehtud uuring "Happy Planet Index" selgitas, millised riigid kasutavad oma kodanike pika ja õnneliku elu saavutamiseks kõige vähem maakera ressursse. Eesti on tabelis 173. kohal. Lisa: Õnnetu planeet

  6. Läänemaa ettevõtjad rahvusvahelise projekti INTO-PRACTISE innovatsiooni uuringus / Eva Makienko

    Index Scriptorium Estoniae

    Makienko, Eva

    2010-01-01

    2009. a. tehti rahvusvahelise projekti Into-Practise raames innovatsiooni käsitlev uuring, et leida vastus küsimusele, kuidas tagada konkurentsivõime ja innovatiivsus organisatsioonides. Uuringus osalesid Kesk-Läänemere piirkonna ettevõtjad ja koolijuhid. Artiklis antakse ülevaade ettevõtjate arvamustest konkurentsivõime tegurite ja innovatsiooni kohta

  7. Enkele polycyclische aromatische koolwaterstoffen (PAH) en stikstofhoudende analoga (N-PAH) in levensmiddelen en ander biologisch materiaal

    NARCIS (Netherlands)

    Vaessen; H.A.M.G.; Wilbers; A.A.M.M.; Jekel; A.A..nf

    1986-01-01

    Beschreven worden de resultaten van het onderzoek van margarine en halvarine (N=28), rundernieren (N=6), maiskiemen (N=1), "vet" uit overstortputjes (N=1), spinazie (N=5), boerenkool (N=8), mosselen (N=10), brood (N=4) en duplicaten van 24-uurs voeding (N=6) op gehalte aan

  8. Místní klimatické zóny a jejich význam ve městech České republiky

    Czech Academy of Sciences Publication Activity Database

    Lehnert, M.; Geletič, Jan

    2017-01-01

    Roč. 20, č. 2 (2017), s. 9-16 ISSN 1212-0855 Institutional support: RVO:86652079 Keywords : local climate zones * air temperature * urban heat island Subject RIV: DG - Athmosphere Sciences, Meteorology OBOR OECD: Climatic research http://www.uur.cz/images/5-publikacni-cinnost-a-knihovna/casopis/2017/2017-02/04-mistni.pdf

  9. The rate of living in tau mutant Syrian hamsters : Studies on the impact of a circadian allele on temporal organisation

    NARCIS (Netherlands)

    Oklejewicz, Malgorzata Marta

    2001-01-01

    De temporele organisatie van gedrag en fysiologie in de meeste organismen is gebaseerd op een inwendig gegenereerd 24 uurs patroon. Deze "circadiane" ritmiciteit is in de evolutie ontstaan als aanpassing aan de aardrotatie. Naast de circadiane oscillatie treden er biologische cvcli op op allerlei

  10. Praxis and the disruption of organized crime groups / Stuart Kirby, Nicki Snow

    Index Scriptorium Estoniae

    Kirby, Stuart

    2016-01-01

    Kuigi kogu arenenud maailmas on uuringute alusel täheldatud kuritegevuse langust ei ole sellist tendentsi märgata organiseeritud kuritegevuse vallas. Antud uuring käsitleb inglise politsei poolt uuritud 15 organiseeritud kuritegelikku rühmitust

  11. Inimlik eksitus Lätis saatis kontrolli kõik Aura mahlajoogid / Hindrek Riikoja

    Index Scriptorium Estoniae

    Riikoja, Hindrek

    2006-01-01

    Tartu Õlletehase liiga suure säilitusaine sisalduse tõttu Lätis müügilt kõrvaldatud Aura Arcticu mahlajoogid tõid kaasa kogu tootesarja ulatusliku kontrolli. Rohkem eksimusi uuring ei tuvastanud. Lisa: Bensoehape

  12. Vaevaline koostöö uute kunstimuuseumide rajamise ja rahastamise protsessis = Thorny collaboration in the processes of founding and funding new art museums : II koht teaduspublikatsioonide kategoorias / Margaret Tali, Laura Pierantoni

    Index Scriptorium Estoniae

    Tali, Margaret

    2009-01-01

    Uuring tutvustab võrdlevalt uute kunstimuuseumide rajamisega seotud motivatsioone kolmes riigis ning mahukate ehitusprojektide rahastamist, keskendudes uute huvigruppide rollile Ida-Euroopa riiklike kunstimuuseumide tegevuses. Töö andmed on kogutud koostöös kolme muuseumiga: LUMU kunstimuuseum Budapestis, KUMU kunstimuuseum Tallinnas ja MSU kunstimuuseum Zagrebis

  13. Explaining cross-national variation in the relationship between priority congruence and satisfaction with democracy / Stefanie Reher

    Index Scriptorium Estoniae

    Reher, Stefanie

    2015-01-01

    Artikkel lähtub hüpoteesist, et kui eliit jagab kodanike muresid, peaks nad suhtuma nendesse ja ühiskonna vajadustesse hoolivamalt. Analüüsi aluseks on 2009. aasta Euroopa valimiste uuring, teiste riikide seas on esindatud ka Eesti

  14. Intending to marry... : students´ behavioural intention towards family forming / Kairi Kasearu

    Index Scriptorium Estoniae

    Kasearu, Kairi

    2010-01-01

    Sotsiaal-demograafilise tausta, perega seotud väärtuste ja lähedaste arvamuste mõjust üliõpilaste kooseluvormi valikule. Uuring tugineb Tartu Ülikoolis ja Eesti Põllumajandusülikoolis 2001. aastal läbiviidud uuringu "Ideals of the Student" andmetele

  15. Tähelepanu! Valmis olla! Jääme vanaks... / Luule Sakkeus ; kommenteerinud Bianca Mikovitš

    Index Scriptorium Estoniae

    Sakkeus, Luule, 1956-

    2015-01-01

    Eestis algab kolmas SHARE uuring (Survey of Health, Ageing and Retirement in Europe), mille käigus saadakse ülevaade 50-aastaste ja vanemate elanike tervislikust seisundist ja toimetulekust. Intervjuu TLÜ Eesti demograafia instituudi direktori ja Eesti 50+ elanikkonna eluoluküsitluse teaduskoordinaatori Luule Sakkeusega eakate olukorrast Eestis

  16. Posted workers remuneration: Comparative study in nine EU countries and four sectors / Jean-Philippe Lhernould, Barbara Palli

    Index Scriptorium Estoniae

    Lhernould, Jean-Philippe

    2017-01-01

    Lähetatud töötajate töötasust, lähetatud töötajate direktiivist. Palga alammäärast liikmesriikides ja lähetatud töötajate palga alammäärast Euroopa Liidu õiguses. Võrdlev uuring üheksas Euroopa Liidu liikmesriigis ja neljas sektoris

  17. Gezond door landbouw en groen. De betekenis van landbouw en groen voor de gezondheid van de stedelijke samenleving

    NARCIS (Netherlands)

    Hassink, J.

    2006-01-01

    De stedelijke gebieden van Nederland krijgen het steeds benauwder. Nieuwbouw verdringt meer en meer het groen in en om de stad, terwijl de 24-uurs-economie de mensen opjaagt. Kwetsbare groepen, onder wie cliënten met een verstandelijke beperking of psychische problematiek, mensen met een

  18. Juuremädanike levik on arvatust ulatuslikum / Tiia Drenkhan, Elisabeth Rähn, Katrin Jürimaa ... [jt.

    Index Scriptorium Estoniae

    2014-01-01

    Maaülikooli metsapatoloogia töörühm uuris aastatel 2012-2014, mil määral on viljakad metsakasvukohatüübid juuremädanike poolt kahjustatud. Projekti "Olulisimate juuremädanike tekitajate leviku ja kahjustuse uuring Eestis" läbiviimist toetas KIK

  19. Segadus : naiste seksuaaldüsfunktsioon / Juhan Kaldre

    Index Scriptorium Estoniae

    Kaldre, Juhan

    2003-01-01

    Ajakirjas "British Medical Journal" ilmus uuring, kus Washingtonis töötav Austraalia ajakirjanik Ray Moynihan süüdistab ravimifirmasid, et nad on sisuliselt leiutanud naiste seksuaaldüsfunktsiooni, et müüa paremini uusi ravimeid

  20. Ulata õng ja õpeta seda kasutama = Teach a man to fish / Merli Mäger, Mihkel Servinski, Garri Raagmaa...[jt.

    Index Scriptorium Estoniae

    2006-01-01

    Uuring ülevaate saamiseks Kagu-Eesti Meremäe, Mikitamäe, Misso, Orava, Vastseliina ja Värska valla sotsiaalsetest, kultuurilistest ja majandusliku jätkusuutlikkusega seotud probleemidest ning piirkonna rahvastiku majandusliku olukorra parandamise abinõude kavandamiseks. Tabelid, diagrammid

  1. Hulkuvate loomade valdkonna käsitlemine kohalike omavalitsuste tasandil = Handling of the stray animal issue at the local government level : III koht bakalaureusetööde kategoorias / Kaili Velleste

    Index Scriptorium Estoniae

    Velleste, Kaili

    2009-01-01

    Töö eesmärgiks oli selgitada, kas kohalikud omavalitsused hindavad hulkuvate ja kodutute loomade valdkonda oluliseks, et sellega tegeleda; kas nad peavad kehtivaid seadusi ja meetmeid piisavateks, et reguleerida hulkuvate loomade arvukust; kuidas suhtutakse loomakaitseseaduse ja loomatauditõrje seaduse muutmise seaduse eelnõus väljatoodud muudatustesse. Uuring viidi läbi Harju maakonna omavalitsustes

  2. De toekomst van Real Time Intelligence

    NARCIS (Netherlands)

    Broek, J. van den; Berg, C.H. van den

    2013-01-01

    Al direct vanaf de start van de Nationale Politie is gewerkt aan het opzetten van tien real-time intelligence centra in Nederland. Van daaruit worden 24 uur per dag en zeven dagen in de week agenten op straat actief ondersteund met real-time informatie bij de melding waar ze op af gaan. In de visie

  3. Eesti "väikestel" jõudu küll / Juhan Teder

    Index Scriptorium Estoniae

    Teder, Juhan, 1960-

    2007-01-01

    Ilmunud ka: Delovõje Vedomosti 9. jaan. 2008 lk. 8. Uuringust "Flash Eurobarometer No 196: Observatory of European EMEs" selgub, et Eesti väike- ja keskmise suurusega ettevõtted on teistega võrreldes päris edukad. Tabel: Uuring

  4. Eesti põllumajanduse ja maaelu hävitamise lugu / Villu Reiljan

    Index Scriptorium Estoniae

    Reiljan, Villu, 1953-

    2001-01-01

    Raamatust: Decollectivisation, destruction and disillusionment. A community study in Southern Estonia. Tallinn: Jyväskylä, 2001. Teos käsitleb Eesti põllumajanduse allakäiku viimase 10 a. jooksul. Uuring Kanepi valla näitel. Autor: ERL. Parlamendisaadik

  5. Sotsiaal-majanduslik staatus tervise tausttegurina / Margo Kikas, Ene Lausvee

    Index Scriptorium Estoniae

    Kikas, Margo

    2008-01-01

    Uuringust seoste kohta Eesti inimeste tunnetatud tervise ning sotsiaal-majandusliku ja psühhosotsiaalse seisundi vahel. Uuring tugineb Tallinna Ülikooli sotsiaaltöö eriala üliõpilaste poolt aastatel 2001-2002 tehtud anonüümsel ankeetküsitlusel põhiliselt toimetulekuraskuste, krooniliste haiguste, puudega või riskikäitumisega isikute seas

  6. Eesti elanike turvatunne ja nende hinnang politseitööle aastal 2006 / Triin Rannama

    Index Scriptorium Estoniae

    Rannama, Triin

    2007-01-01

    Uuringu "Elanike hinnangud Eesti politseile 2006" tulemused näitavad, et hinnangud politsei tegevusele on paranenud, kuid elanike turvatunne on vähenenud. Lisa: Nii valmis uuring "Elanike hinnangud Eesti politseile 2006". Diagrammid: Hinnangud erinevatele politseiga seonduvatele omadustele 2006. aastal; Elanike turvatunne 2006. aastal; Elanike rahulolu politsei tööga regioonides; Rahulolu prefektuuriti

  7. Iga viies SVH on ennetatav

    Index Scriptorium Estoniae

    2009-01-01

    ONTARGET uuring tõestab, et telmisartaan kaitseb kõrge kardiovaskulaarse riskiga patsiente sama tõhusalt kui ramipriil, kuid on paremini talutav. Uuringust võib järeldada, et telmisartaaniga saab ennetada iga viiendat tõsist kardiovaskulaarset juhtumit. Eesti arstidele tutvustati uuringut 6. mail toimunud sümpoosiumil

  8. 'Gun koeien hun vrijheid' : weidegang de beste benutting van grasland

    NARCIS (Netherlands)

    Wal, van der G.

    2007-01-01

    Omdat Leen Groeneveld uit Tolbert niet meer iedere dag vier uur in de melkput kon staan, stond hij voor de keuze verbouwen of een melkrobot aanschaffen. Hij begon met een tweedehands melkrobot, binnen veertien dagen had hij spijt van zijn beslissing. Door allerlei perikelen begon de melkgift te

  9. Jaekaubandus kaotab kaubakadudest 1,27% käibest

    Index Scriptorium Estoniae

    2006-01-01

    Ilmunud ka: Finansovõi Menedzhment : infovõpusk nr. 3 apr. lk. 8. Briti firma The Centre for Retail Research uuring näitas, et Baltimaade suurte jaekaubandusfirmade keskmine kaubakadu 2005. aastal oli 1,27% käibest. Tabel: Euroopa jaekaubafirmade kahjud kadude tõttu (% käibest)

  10. Duur van computergebruik in het bankwezen : tikken, klikken en kijken

    NARCIS (Netherlands)

    Douwes, M.; Blatter, B.M.; Kraker, H. de

    2003-01-01

    Het arboconvenant Bankwezen zegt: zorg voor niet meer dan vijf uur beeldschermwerk per persoon per dag. Voor het meten van die tijdsduur is een meetmethode nodig. Met pauzesoftware kan de tijdsduur van toetsenbordgebruik en van muisgebruik gemeten worden, maar kijken naar het beeldscherm alleen

  11. Schermgebruik en blauw licht : Omvang van blootstelling en relatie met slaap

    NARCIS (Netherlands)

    van Kerkhof LWM; Vlaanderen JJ; Berkhout AJC; Dollé MET; Vermeulen RCH; van Steeg H; EVG; V&Z

    2017-01-01

    Veel volwassenen (58 procent) gebruiken in het laatste uur voordat ze gaan slapen een tablet, smartphone of computer. Ze doen dit meerdere keren per week of dagelijks. Het gebruik van deze apparaten kort voor het slapen gaat gepaard met minder en slechter slapen. Of het blauwe licht van deze

  12. Infopädevus on 21. sajandi teema : raamatukoguhoidjate teadmised, oskused ja hoiakud / Jaana Kulbin

    Index Scriptorium Estoniae

    Kulbin, Jaana

    2015-01-01

    2014. aasta veebruaris viidi Tallinna kutse- ja kõrgkoolides läbi uuring, mille eesmärk oli välja selgitada kuidas kutse- ja kõrgkoolide raamatukoguhoidjad hindavad oma infopädevust ning milliseid teadmisi, oskusi ja hoiakuid peavad raamatukoguhoidjad oluliseks kasutajate infopädevuse arendamisel

  13. Who feels inferior? A test of the status anxiety hypothesis of social inequalities in health / Richard Layte, Christopher T. Whelan

    Index Scriptorium Estoniae

    Layte, Richard

    2014-01-01

    Artikli üldteemaks on sissetulekute ebavõrdsuse, tervise ja teiste sotsiaalprobleemide seosed, konkreetne uurimisobjekt on staatusest tuleneva ärevuse mõju sotsiaalsele ebavõrdsusele tervises, aluseks 31-s Euroopa riigis (sh Eesti) 2007. aastal läbiviidud elukvaliteedi uuring

  14. Genetic Variation of the Endangered Neotropical Catfish Steindachneridion scriptum (Siluriformes: Pimelodidae

    Directory of Open Access Journals (Sweden)

    Rômulo V. Paixão

    2018-02-01

    Full Text Available Steindachneridion scriptum is an important species as a resource for fisheries and aquaculture; it is currently threatened and has a reduced occurrence in South America. The damming of rivers, overfishing, and contamination of freshwater environments are the main impacts on the maintenance of this species. We accessed the genetic diversity and structure of S. scriptum using the DNA barcode and control region (D-loop sequences of 43 individuals from the Upper Uruguay River Basin (UUR and 10 sequences from the Upper Paraná River Basin (UPR, which were obtained from GenBank. S. scriptum from the UUR and the UPR were assigned in two distinct molecular operational taxonomic units (MOTUs with higher inter-specific K2P distance than the optimum threshold (OT = 0.0079. The COI Intra-MOTU distances of S. scriptum specimens from the UUR ranged from 0.0000 to 0.0100. The control region indicated a high number of haplotypes and low nucleotide diversity, compatible with a new population in recent expansion process. Genetic structure was observed, with high differentiation between UUR and UPR basins, identified by BAPS, haplotype network, AMOVA (FST = 0.78, p < 0.05 and Mantel test. S. scriptum from the UUR showed a slight differentiation (FST = 0.068, p < 0.05, but not isolation-by-distance. Negative values of Tajima’s D and Fu’s Fs suggest recent demographic oscillations. The Bayesian skyline plot analysis indicated possible population expansion from beginning 2,500 years ago and a recent reduction in the population size. Low nucleotide diversity, spatial population structure, and the reduction of effective population size should be considered for the planning of strategies aimed at the conservation and rehabilitation of this important fisheries resource.

  15. Comparative genome analysis of 19 Ureaplasma urealyticum and Ureaplasma parvum strains.

    Science.gov (United States)

    Paralanov, Vanya; Lu, Jin; Duffy, Lynn B; Crabb, Donna M; Shrivastava, Susmita; Methé, Barbara A; Inman, Jason; Yooseph, Shibu; Xiao, Li; Cassell, Gail H; Waites, Ken B; Glass, John I

    2012-05-30

    Ureaplasma urealyticum (UUR) and Ureaplasma parvum (UPA) are sexually transmitted bacteria among humans implicated in a variety of disease states including but not limited to: nongonococcal urethritis, infertility, adverse pregnancy outcomes, chorioamnionitis, and bronchopulmonary dysplasia in neonates. There are 10 distinct serotypes of UUR and 4 of UPA. Efforts to determine whether difference in pathogenic potential exists at the ureaplasma serovar level have been hampered by limitations of antibody-based typing methods, multiple cross-reactions and poor discriminating capacity in clinical samples containing two or more serovars. We determined the genome sequences of the American Type Culture Collection (ATCC) type strains of all UUR and UPA serovars as well as four clinical isolates of UUR for which we were not able to determine serovar designation. UPA serovars had 0.75-0.78 Mbp genomes and UUR serovars were 0.84-0.95 Mbp. The original classification of ureaplasma isolates into distinct serovars was largely based on differences in the major ureaplasma surface antigen called the multiple banded antigen (MBA) and reactions of human and animal sera to the organisms. Whole genome analysis of the 14 serovars and the 4 clinical isolates showed the mba gene was part of a large superfamily, which is a phase variable gene system, and that some serovars have identical sets of mba genes. Most of the differences among serovars are hypothetical genes, and in general the two species and 14 serovars are extremely similar at the genome level. Comparative genome analysis suggests UUR is more capable of acquiring genes horizontally, which may contribute to its greater virulence for some conditions. The overwhelming evidence of extensive horizontal gene transfer among these organisms from our previous studies combined with our comparative analysis indicates that ureaplasmas exist as quasi-species rather than as stable serovars in their native environment. Therefore, differential

  16. Uus postimüügikataloog üritab end Eesti turule sisse süüa sõbra soovituste kaudu / Eda-Liis Kann, Tiina Kilkson

    Index Scriptorium Estoniae

    Kann, Eda-Liis, 1979-

    2005-01-01

    TNS Emori uuring kinnitab, et kaks kolmandikku Eesti inimestest on valmis tegema sõprade soovitusel olulisi ostuotsuseid. Sellest lähtub ka Eesti ja Läti turule tulnud uus postimüügikataloog Neckermann, kes kasutab oma nn ekspertprogrammis ekspertidena tavalisi inimesi erinevatelt elualadelt. Vt. samas: Naistele meeldib katalooge lapata; Kataloogidele Eestis ruumi jagub; Ellos lõpetas Eestis postimüügi

  17. Aasta tegu

    Index Scriptorium Estoniae

    2014-01-01

    Eesti Kooriühingu aasta tegudeks valiti Erich Whitacrei autorikontsert ja meistrikursus noortele dirigentidele Eestis 2013. a mais, Harjumaa Laulu- ja tantsupidu "Ajamustrid" 1. juunil 2013 Keilas, raamat "Kogemuste kuld. Vestlusi koorijuhtidega", sotsioloogiline uuring "Minu laulu- ja tantsupidu" ja konverents "Laulu- ja tantsupeo puudutus ajas", vabariiklik segakooride laulupäev "Õitse, kasva, ela" 15. juunil 2013 Elvas, Veljo Tormise tsükli "Unustatud rahvad" täispikkuses esmaettekanne ja Üle-Eestiline meeskoor Estole

  18. Metshtõ o "Nokii" i proza zhizni / Eteri Kekelidze

    Index Scriptorium Estoniae

    Kekelidze, Eteri, 1944-

    2006-01-01

    TTÜ professor Väino Rajangu tehtud uuring näitab, et üsna paljud kõrgkooli lõpetanud omandavad teise eriala kutsekoolis ning põhikooli lõpetanud lähevad üha sagedamini õppima kutsekooli. Tema hinnangul erineb Eestis tööturg haridusturust ning põhimõte, et turg ise reguleerib, haridussüsteemi puhul ei tööta

  19. Evidence that the mitochondrial leucyl tRNA synthetase (LARS2) gene represents a novel type 2 diabetes susceptibility gene

    DEFF Research Database (Denmark)

    hart, Leen M; Hansen, Torben; Rietveld, Ingrid

    2005-01-01

    Previously, we have shown that a mutation in the mitochondrial DNA-encoded tRNA(Leu(UUR)) gene is associated with type 2 diabetes. One of the consequences of this mutation is a reduced aminoacylation of tRNA(Leu(UUR)). In this study, we have examined whether variants in the leucyl tRNA synthetase...... gene (LARS2), involved in aminoacylation of tRNA(Leu(UUR)), associate with type 2 diabetes. Direct sequencing of LARS2 cDNA from 25 type 2 diabetic subjects revealed eight single nucleotide polymorphisms. Two of the variants were examined in 7,836 subjects from four independent populations...... in the Netherlands and Denmark. A -109 g/a variant was not associated with type 2 diabetes. Allele frequencies for the other variant, H324Q, were 3.5% in type 2 diabetic and 2.7% in control subjects, respectively. The common odds ratio across all four studies was 1.40 (95% CI 1.12-1.76), P = 0.004. There were...

  20. Urinary excretion of uric acid is negatively associated with albuminuria in patients with chronic kidney disease: a cross-sectional study.

    Science.gov (United States)

    Li, Fengqin; Guo, Hui; Zou, Jianan; Chen, Weijun; Lu, Yijun; Zhang, Xiaoli; Fu, Chensheng; Xiao, Jing; Ye, Zhibin

    2018-04-24

    Increasing evidence has shown that albuminuria is related to serum uric acid. Little is known about whether this association may be interrelated via renal handling of uric acid. Therefore, we aim to study urinary uric acid excretion and its association with albuminuria in patients with chronic kidney disease (CKD). A cross-sectional study of 200 Chinese CKD patients recruited from department of nephrology of Huadong hospital was conducted. Levels of 24 h urinary excretion of uric acid (24-h Uur), fractional excretion of uric acid (FEur) and uric acid clearance rate (Cur) according to gender, CKD stages, hypertension and albuminuria status were compared by a multivariate analysis. Pearson and Spearman correlation and multiple regression analyses were used to study the correlation of 24-h Uur, FEur and Cur with urinary albumin to creatinine ratio (UACR). The multivariate analysis showed that 24-h Uur and Cur were lower and FEur was higher in the hypertension group, stage 3-5 CKD and macro-albuminuria group (UACR> 30 mg/mmol) than those in the normotensive group, stage 1 CKD group and the normo-albuminuria group (UACRuric acid is negatively associated with albuminuria in patients with CKD. This phenomenon may help to explain the association between albuminuria and serum uric acid.

  1. Iga neljas Eestimaa laps elab allpool vaesuspiiri / Elle Kull

    Index Scriptorium Estoniae

    Kull, Elle, 1952-

    2007-01-01

    Ilmunud ka: Lääne Elu, 25. jaan. 2007, lk. 2; Valgamaalane, 25. jaan. 2007, lk. 2; Lõunaleht, 25. jaan. 2007, lk. 2; Sakala, 26. jaan. 2007, lk. 2; Den za Dnjom, 26. jaan. 2007, lk. 18; Meie Maa, 26. jaan. 2007, lk. 2; Nädaline, 30. jaan. 2007, lk. 4; Vooremaa, 30. jaan. 2007, lk. 2; Järva Teataja, 1. veebr. 2007, lk. 2. Yorki ülikooli ja UNICEF-i laste heaoluindeksi uuring paigutab Eesti lapsed EL-i 25 riigi seas eelviimasele kohale. Parlamendiliige tõstatab Eesti perepoliitika valupunktid

  2. Narrimine viis Saku tüdruku enesetapuni / Marko Püüa

    Index Scriptorium Estoniae

    Püüa, Marko

    2003-01-01

    Koolivägivallast ja koolikiusamisest, mis on viinud õpilasi enesetapuni. Lähemalt on juttu Saku gümnaasiumis õppinud 13-aastase koolitüdruku enesetapust. 2002. a. 36 riigis läbi viidid kooliõpilaste tervisekäitumise uuring näitas, et teiste riikidega võrreldes ei meeldi Eestis 11-15-aastastele koolis käia, samution eesti lapsed agressiivsed. Lisaartiklis on juttu noorteühingust Tugiõpilaste Oma Ring Eestis (T.O.R.E.), mis võitleb koolivägivallaga ja aitab noorte enesetappe ennetada

  3. Casuïstiek van sociaal werkers, schatkamer of trompe-l'oeil?

    Directory of Open Access Journals (Sweden)

    Hilde Vlaeminck

    2005-12-01

    Full Text Available Casuïstiek is van oudsher een beproefd leermiddel in de geneeskunde en de moraalwetenschappen maar ook in het maatschappelijk werk. De oudste methodiek in het maatschappelijk werk – niet toevallig Social Casework genoemd – bestudeerde zorgvuldig praktijkgevallen, verteld door maatschappelijk werkers van het eerste uur (Kamphuis, 1971. Men trachtte toen de opgemerkte fenomenen en vastgestelde effecten te beschrijven, te verklaren en te verantwoorden met behulp van beschikbare wetenschappelijke kennis. Een eerste, opmerkelijke stap in een lang proces van professionalisering en kennisontwikkeling.

  4. MELAS Syndrome with Cardiac Involvement: A Multimodality Imaging Approach

    Directory of Open Access Journals (Sweden)

    Sara Seitun

    2016-01-01

    Full Text Available A 49-year-old man presented with chest pain, dyspnea, and lactic acidosis. Left ventricular hypertrophy and myocardial fibrosis were detected. The sequencing of mitochondrial genome (mtDNA revealed the presence of A to G mtDNA point mutation at position 3243 (m.3243A>G in tRNALeu(UUR gene. Diagnosis of cardiac involvement in a patient with Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like episodes syndrome (MELAS was made. Due to increased risk of sudden cardiac death, cardioverter defibrillator was implanted.

  5. Sodium Fast Reactor Safety and Licensing Research Plan

    International Nuclear Information System (INIS)

    Denman, Matthew; Lachance, Jeff; Sofu, Tanju; Wigeland, Roald; Flanagan, George; Bari, Robert

    2013-01-01

    Conclusions: The Sodium Fast Reactor Safety and Licensing Research Plan reports conclude a multi-year expert elicitation process. All information included in the studies are publicly available and the reports are UUR. These reports are intended to guide SFR researchers in the safety and licensing arena to important and outstanding issues Two (and a half) projects have been funded based on the recommendations in this report: • Modernization of SAS4A; • Incorporation of Contain/LMR with MELCOR; • (Data recovery at INL and PNNL)

  6. Pathology of mitochondria in MELAS syndrome: an ultrastructural study.

    Science.gov (United States)

    Felczak, Paulina; Lewandowska, Eliza; Stępniak, Iwona; Ołdak, Monika; Pollak, Agnieszka; Lechowicz, Urszula; Pasennik, Elżbieta; Stępień, Tomasz; Wierzba-Bobrowicz, Teresa

    Ultrastructural changes in skeletal muscle biopsy in a 24-year-old female patient with clinically suspected mitochondrial encephalomyopathy lactic acidosis and stroke-like episodes (MELAS) syndrome are presented. We observed proliferation and/or pleomorphism of mitochondria in skeletal muscle and smooth muscle cells of arterioles, as well as in pericytes of capillaries. Paracrystalline inclusions were found only in damaged mitochondria of skeletal muscle. Genetic testing revealed a point mutation in A3243G tRNALeu(UUR) typical for MELAS syndrome. We conclude that differentiated pathological changes of mitochondria in the studied types of cells may be associated with the different energy requirements of these cells.

  7. Report of an exploratory study on vacuum drying of flower bulbs; Verslag orienterend onderzoek vacuumdrogen bloembollen

    Energy Technology Data Exchange (ETDEWEB)

    Dijkema, M.; Van der Klugt, J.W.

    2010-03-15

    In an exploratory practical study, several questions were answered with regard to vacuum drying. What are the effects on growing and flowering of flower bulbs: (1) of vacuum drying; (2) of half an hour of zero oxygen immediately after harvesting; and (3) of strong temperature shift immediately after harvesting? In addition, the following questions were answered: (4) do flower bulbs dry sufficiently in half an hour of vacuum?; (5) how do fungi and bacteria respond to half an hour in vacuum?; (6) how do animal pests (e.g. bulb mite)react to vacuum? [Dutch] In een orienterende praktijkproef is een aantal vragen beantwoord met betrekking tot vacuumdrogen. Wat zijn de effecten op de groei en de bloei van bloembollen: (1) van vacuumdrogen; (2)van een half uur zuurstofloosheid direct na de oogst?; en (3) van een sterke temperatuurwisseling direct na de oogst?. Daarnaast werden de volgende vragen beantwoord: (4) drogen bloembollen voldoende in een half uur vacuum?; (5) hoe reageren schimmels en bacterien op het vacuum?; (6) hoe reageren dierlijke aantasters (o.a. bollenmijt) op het vacuum?.

  8. [MELAS: Mitochondrial Encephalomyopathy, Lactic Acidosis and Stroke-Like Episodes].

    Science.gov (United States)

    Murakami, Hidetomo; Ono, Kenjiro

    2017-02-01

    Mitochondrial disease is caused by a deficiency in the energy supply to cells due to mitochondrial dysfunction. Mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS) is a mitochondrial disease that presents with stroke-like episodes such as acute onset of neurological deficits and characteristic imaging findings. Stroke-like episodes in MELAS have the following features: 1) neurological deficits due to localization of lesions in the brain, 2) episodes often accompany epilepsy, 3) lesions do not follow the vascular supply area, 4) lesions are more often seen in the posterior brain than in the anterior brain, 5) lesions spread to an adjacent area in the brain, and 6) neurological symptoms often disappear together with imaging findings, but later relapse. About 80% of patients with MELAS have an A-to-G transition mutation at the nucleotide pair 3243 in the dihydrouridine loop of mitochondrial tRNALeu(UUR), which causes the absence of posttranscriptional taurine modification at the wobble nucleotide of mitochondrial tRNALeu(UUR) and disrupts protein synthesis. However, the precise pathophysiology of stroke-like episodes is under investigation, with possible hypotheses for these episodes including mitochondrial angiopathy, mitochondrial cytopathy, and neuron-astrocyte uncoupling. With regard to treatment, L-arginine and taurine have recently been suggested for relief of clinical symptoms.

  9. Correction of the consequences of mitochondrial 3243A>G mutation in the MT-TL1 gene causing the MELAS syndrome by tRNA import into mitochondria.

    Science.gov (United States)

    Karicheva, Olga Z; Kolesnikova, Olga A; Schirtz, Tom; Vysokikh, Mikhail Y; Mager-Heckel, Anne-Marie; Lombès, Anne; Boucheham, Abdeldjalil; Krasheninnikov, Igor A; Martin, Robert P; Entelis, Nina; Tarassov, Ivan

    2011-10-01

    Mutations in human mitochondrial DNA are often associated with incurable human neuromuscular diseases. Among these mutations, an important number have been identified in tRNA genes, including 29 in the gene MT-TL1 coding for the tRNA(Leu(UUR)). The m.3243A>G mutation was described as the major cause of the MELAS syndrome (mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes). This mutation was reported to reduce tRNA(Leu(UUR)) aminoacylation and modification of its anti-codon wobble position, which results in a defective mitochondrial protein synthesis and reduced activities of respiratory chain complexes. In the present study, we have tested whether the mitochondrial targeting of recombinant tRNAs bearing the identity elements for human mitochondrial leucyl-tRNA synthetase can rescue the phenotype caused by MELAS mutation in human transmitochondrial cybrid cells. We demonstrate that nuclear expression and mitochondrial targeting of specifically designed transgenic tRNAs results in an improvement of mitochondrial translation, increased levels of mitochondrial DNA-encoded respiratory complexes subunits, and significant rescue of respiration. These findings prove the possibility to direct tRNAs with changed aminoacylation specificities into mitochondria, thus extending the potential therapeutic strategy of allotopic expression to address mitochondrial disorders.

  10. Development of a multilocus sequence typing scheme for Ureaplasma.

    Science.gov (United States)

    Zhang, J; Kong, Y; Feng, Y; Huang, J; Song, T; Ruan, Z; Song, J; Jiang, Y; Yu, Y; Xie, X

    2014-04-01

    Ureaplasma is a commensal of the human urogenital tract but is always associated with invasive diseases such as non-gonococcal urethritis and infertility adverse pregnancy outcomes. To better understand the molecular epidemiology and population structure of Ureaplasma, a multilocus sequence typing (MLST) scheme based on four housekeeping genes (ftsH, rpL22, valS, thrS) was developed and validated using 283 isolates, including 14 serovars of reference strains and 269 strains obtained from clinical patients. A total of 99 sequence types (STs) were revealed: the 14 type strains of the Ureaplasma serovars were assigned to 12 STs, and 87 novel and special STs appeared among the clinical isolates. ST1 and ST22 were the predominant STs, which contained 68 and 70 isolates, respectively. Two clonal lineages (CC1 and CC2) were shown by eBURST analysis, and linkage disequilibrium was revealed through a standardized index of association (I A (S)). The neighbor-joining tree results of 14 Ureaplasma serovars showed two genetically significantly distant clusters, which was highly congruent with the species taxonomy of ureaplasmas [Ureaplasma parvum (UPA) and Ureaplasma urealyticum (UUR)]. Analysis of the biotypes of 269 clinical isolates revealed that all the isolates of CC1 were UPA and those of CC2 were UUR. Additionally, CC2 was found more often in symptomatic patients with vaginitis, tubal obstruction, and cervicitis. In conclusion, this MLST scheme is adequate for investigations of molecular epidemiology and population structure with highly discriminating capacity.

  11. The ROS-sensitive microRNA-9/9* controls the expression of mitochondrial tRNA-modifying enzymes and is involved in the molecular mechanism of MELAS syndrome.

    Science.gov (United States)

    Meseguer, Salvador; Martínez-Zamora, Ana; García-Arumí, Elena; Andreu, Antonio L; Armengod, M-Eugenia

    2015-01-01

    Mitochondrial dysfunction activates mitochondria-to-nucleus signaling pathways whose components are mostly unknown. Identification of these components is important to understand the molecular mechanisms underlying mitochondrial diseases and to discover putative therapeutic targets. MELAS syndrome is a rare neurodegenerative disease caused by mutations in mitochondrial (mt) DNA affecting mt-tRNA(Leu(UUR)). Patient and cybrid cells exhibit elevated oxidative stress. Moreover, mutant mt-tRNAs(Leu(UUR)) lack the taurine-containing modification normally present at the wobble uridine (U34) of wild-type mt-tRNA(Leu(UUR)), which is considered an etiology of MELAS. However, the molecular mechanism is still unclear. We found that MELAS cybrids exhibit a significant decrease in the steady-state levels of several mt-tRNA-modification enzymes, which is not due to transcriptional regulation. We demonstrated that oxidative stress mediates an NFkB-dependent induction of microRNA-9/9*, which acts as a post-transcriptional negative regulator of the mt-tRNA-modification enzymes GTPBP3, MTO1 and TRMU. Down-regulation of these enzymes by microRNA-9/9* affects the U34 modification status of non-mutant tRNAs and contributes to the MELAS phenotype. Anti-microRNA-9 treatments of MELAS cybrids reverse the phenotype, whereas miR-9 transfection of wild-type cells mimics the effects of siRNA-mediated down-regulation of GTPBP3, MTO1 and TRMU. Our data represent the first evidence that an mt-DNA disease can directly affect microRNA expression. Moreover, we demonstrate that the modification status of mt-tRNAs is dynamic and that cells respond to stress by modulating the expression of mt-tRNA-modifying enzymes. microRNA-9/9* is a crucial player in mitochondria-to-nucleus signaling as it regulates expression of nuclear genes in response to changes in the functional state of mitochondria. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please email

  12. Vacature

    CERN Document Server

    2008-01-01

    NTC Genève (Vereniging Nederlandse Taal en Cultuur) verzorgt in en om Genève Nederlands onderwijs voor het primair en voortgezet onderwijs. (Zie ook http://www.ntcgeneve.info/.) NTC zoekt voor het komend schooljaar parttime docenten (m/v) (vanaf 2 uur per week) zowel voor het Primair Onderwijs als voor het Voortgezet Onderwijs, met name voor de IB-opleiding Voor het Primair Onderwijs dienen geïnteresseerden een PABO opleiding voltooid te hebben. Voor de IB-opleiding een universitaire talen-opleiding. Salaris en werktijden zullen in onderling overleg worden vastgesteld. Bent u geïnteresseerd ? Stuur dan voor uw sollicitatie, inclusief uw curriculum vitae, per email naar Helene Oppelaar-van Dijck: mailto:dirkhelene@bluewin.ch

  13. Spectroscopic and thermal properties of uranium relevant to atomic schemes for laser isotope separation

    International Nuclear Information System (INIS)

    Ahmad, S.A.; Pandey, P.L.

    1980-01-01

    Spectroscopic data on uranium atom and thermal properties of uranium relevant to atomic schemes for laser isotope separation have been presented in this report. All the relevant spectroscopic data reported in literature so far, as well as some other parameters like photo-absorption cross sections, branching ratios, effects of magnetic and electric fields, evaluated using the existing data, have been presented here. Among the thermal properties, parameters like vapour pressure and number densities for U/Liquid U, U/URe 2 and U/UP systems, partition function, percentage population distribution in energy levels, thermal ionisation and velocities of uranium atom have been presented at different temperatures. Different possible collision processes are mentioned and cross-sections of U-U + charge-exchange and U + + e radiative recombination processes have been also evaluated. (author)

  14. When should MELAS (Mitochondrial myopathy, Encephalopathy, Lactic Acidosis, and Stroke-like episodes) be the diagnosis?

    Science.gov (United States)

    Lorenzoni, Paulo José; Werneck, Lineu Cesar; Kay, Cláudia Suemi Kamoi; Silvado, Carlos Eduardo Soares; Scola, Rosana Herminia

    2015-11-01

    Mitochondrial myopathy, Encephalopathy, Lactic Acidosis, and Stroke-like episodes (MELAS) is a rare mitochondrial disorder. Diagnostic criteria for MELAS include typical manifestations of the disease: stroke-like episodes, encephalopathy, evidence of mitochondrial dysfunction (laboratorial or histological) and known mitochondrial DNA gene mutations. Clinical features of MELAS are not necessarily uniform in the early stages of the disease, and correlations between clinical manifestations and physiopathology have not been fully elucidated. It is estimated that point mutations in the tRNALeu(UUR) gene of the DNAmt, mainly A3243G, are responsible for more of 80% of MELAS cases. Morphological changes seen upon muscle biopsy in MELAS include a substantive proportion of ragged red fibers (RRF) and the presence of vessels with a strong reaction for succinate dehydrogenase. In this review, we discuss mainly diagnostic criterion, clinical and laboratory manifestations, brain images, histology and molecular findings as well as some differential diagnoses and current treatments.

  15. Screening of effective pharmacological treatments for MELAS syndrome using yeasts, fibroblasts and cybrid models of the disease.

    Science.gov (United States)

    Garrido-Maraver, Juan; Cordero, Mario D; Moñino, Irene Domínguez; Pereira-Arenas, Sheila; Lechuga-Vieco, Ana V; Cotán, David; De la Mata, Mario; Oropesa-Ávila, Manuel; De Miguel, Manuel; Bautista Lorite, Juan; Rivas Infante, Eloy; Alvarez-Dolado, Manuel; Navas, Plácido; Jackson, Sandra; Francisci, Silvia; Sánchez-Alcázar, José A

    2012-11-01

    MELAS (mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes) is a mitochondrial disease most usually caused by point mutations in tRNA genes encoded by mitochondrial DNA (mtDNA). Approximately 80% of cases of MELAS syndrome are associated with a m.3243A > G mutation in the MT-TL1 gene, which encodes the mitochondrial tRNALeu (UUR). Currently, no effective treatments are available for this chronic progressive disorder. Treatment strategies in MELAS and other mitochondrial diseases consist of several drugs that diminish the deleterious effects of the abnormal respiratory chain function, reduce the presence of toxic agents or correct deficiencies in essential cofactors. We evaluated the effectiveness of some common pharmacological agents that have been utilized in the treatment of MELAS, in yeast, fibroblast and cybrid models of the disease. The yeast model harbouring the A14G mutation in the mitochondrial tRNALeu(UUR) gene, which is equivalent to the A3243G mutation in humans, was used in the initial screening. Next, the most effective drugs that were able to rescue the respiratory deficiency in MELAS yeast mutants were tested in fibroblasts and cybrid models of MELAS disease. According to our results, supplementation with riboflavin or coenzyme Q(10) effectively reversed the respiratory defect in MELAS yeast and improved the pathologic alterations in MELAS fibroblast and cybrid cell models. Our results indicate that cell models have great potential for screening and validating the effects of novel drug candidates for MELAS treatment and presumably also for other diseases with mitochondrial impairment. © 2012 The Authors. British Journal of Pharmacology © 2012 The British Pharmacological Society.

  16. Supply of dry ambient air in Alstroemenia. Test on the impact of the supply of dry ambient air on the microclimate and crops in alstroemeria; Droge buitenlucht toevoeren in Alstroemeria. Praktijkproef naar de invloed van droge buitenlucht toevoeren op microklimaat en gewas in alstroemeria

    Energy Technology Data Exchange (ETDEWEB)

    Van der Helm, F.; Van Weel, P.; Raaphorst, M.

    2012-08-15

    After one year of dry air distribution in Alstroemeria it is shown that it can effectively lower the vapour deficit between the leaves. It resulted in a decrease of leaf tip damage of 70% compared to the reference, but not to a decrease of spontaneously broken stems. The research is conducted in practice at Hoogenboom Alstroemeria on 1000 m{sup 2} within a larger greenhouse compartment planted with the variety 'Primadonna'. Wageningen UR has conducted the research with an air distribution system of 8 m{sup 3}/m{sup 2} from supplier Lekhabo. The dry air was distributed in the crop by two transparent air tubes. Climate could not be controlled in the research area separate from the reference, therefore more dry air was required than expected, which is contradictive with energy saving. Growers that want to use dry air to either to prevent leaf tips or to save energy will have to find a balance between these two benefits that partly contradict. Both advantages are required to make the investment profitable. It is calculated that nurseries with a relatively small heat and power cogeneration and greenhouses that are already equipped with a second screen can probably profitably invest in a simple and small capacity dry air distribution system [Dutch] Na ruim een jaar opgewarmde buitenlucht toevoeren in Alstroemeria is duidelijk geworden dat hiermee effectief het vocht deficit tussen het gewas verlaagd kan worden. Dit leidde in dit onderzoek tot een afname van vochtblaadjes van 70%, maar niet tot minder afgroeiers. De proef is uitgevoerd in 1000 m{sup 2} binnen een afdeling met het ras Primadonna bij het bedrijf Hoogenboom alstroemeria in Nieuwe Wetering. De proef is door Wageningen UR glastuinbouw uitgevoerd met een installatie voor aanvoer van 8m{sup 3}/m{sup 2} per uur lucht door twee slurven aan de zijkant van het bed. In de proefomgeving kon het klimaat niet apart geregeld worden op het toevoeren van buitenlucht. Hierdoor is steeds relatief veel buitenlucht

  17. Intercomparison Contracted Partner Institutes for Nuclear Emergency 2007; Ringonderzoek waakvlaminstituten kernongevallenbestrijding 2007

    Energy Technology Data Exchange (ETDEWEB)

    Overwater-van Buuren, R.M.W.; Glastra, P.; Tukker, K.

    2009-07-01

    de kernramp in Tsjernobyl. Het RIVM coordineert de activiteiten van de WVI's. De Waakvlaminstituten worden tweejaarlijks getest in de vorm van ringonderzoeken. Hierin wordt beoordeeld of de analyseresultaten op tijd zijn aangeleverd en of ze binnen de afgesproken grenzen overeenkomen. Het lukte de meeste WVI's om de resultaten voor de luchtmonsters binnen twee uur aan te leveren en de resultaten voor de watermonsters binnen 24 uur. De metingen aan de luchtmonsters vielen voor een instituut buiten de gestelde marge. Voor het onderzoek zijn vier monsters aangemaakt: een aerosolfilter, een koolfilter, een koolpatroon en een watermonster. Ze waren alle vier voorzien van radionucliden die voor kernongevallen karakteristiek zijn.

  18. Impaired mitochondrial Ca2+ homeostasis in respiratory chain-deficient cells but efficient compensation of energetic disadvantage by enhanced anaerobic glycolysis due to low ATP steady state levels

    International Nuclear Information System (INIS)

    Kleist-Retzow, Juergen-Christoph von; Hue-Tran Hornig-Do; Schauen, Matthias; Eckertz, Sabrina; Tuan Anh Duong Dinh; Stassen, Frank; Lottmann, Nadine; Bust, Maria; Galunska, Bistra; Wielckens, Klaus; Hein, Wolfgang; Beuth, Joseph; Braun, Jan-Matthias; Fischer, Juergen H.; Ganitkevich, Vladimir Y.; Maniura-Weber, Katharina; Wiesner, Rudolf J.

    2007-01-01

    Energy-producing pathways, adenine nucleotide levels, oxidative stress response and Ca 2+ homeostasis were investigated in cybrid cells incorporating two pathogenic mitochondrial DNA point mutations, 3243A > G and 3302A > G in tRNA Leu(UUR) , as well as Rho 0 cells and compared to their parental 143B osteosarcoma cell line. All cells suffering from a severe respiratory chain deficiency were able to proliferate as fast as controls. The major defect in oxidative phosphorylation was efficiently compensated by a rise in anaerobic glycolysis, so that the total ATP production rate was preserved. This enhancement of glycolysis was enabled by a considerable decrease of cellular total adenine nucleotide pools and a concomitant shift in the AMP + ADP/ATP ratios, while the energy charge potential was still in the normal range. Further important consequences were an increased production of superoxide which, however, was neither escorted by major changes in the antioxidative defence systems nor was it leading to substantial oxidative damage. Most interestingly, the lowered mitochondrial membrane potential led to a disturbed intramitochondrial calcium homeostasis, which most likely is a major pathomechanism in mitochondrial diseases

  19. Thermoelectric Conversion of Waste Heat to Electricity in an IC Engine Powered Vehicle

    Energy Technology Data Exchange (ETDEWEB)

    None

    2012-01-31

    The thermoelectric generator shorting system provides the capability to monitor and short-out individual thermoelectric couples in the event of failure. This makes the series configured thermoelectric generator robust to individual thermoelectric couple failure. Open circuit detection of the thermoelectric couples and the associated short control is a key technique to ensure normal functionality of the TE generator under failure of individual TE couples. This report describes a five-year effort whose goal was the understanding the issues related to the development of a thermoelectric energy recovery device for a Class-8 truck. Likely materials and important issues related to the utility of this generator were identified. Several prototype generators were constructed and demonstrated. The generators developed demonstrated several new concepts including advanced insulation, couple bypass technology and the first implementation of skutterudite thermoelectric material in a generator design. Additional work will be required to bring this system to fruition. However, such generators offer the possibility of converting energy that is otherwise wasted to useful electric power. Uur studies indicate that this can be accomplished in a cost-effective manner for this application.

  20. Energy conservation by means of reduced circulation. On/off versus frequency control; Energiebesparing door verminderde circulatie. Aan/uit- versus Frequentieregeling

    Energy Technology Data Exchange (ETDEWEB)

    Wildschut, J.; Gude, H. [Praktijkonderzoek Plant en Omgeving PPO, Bloembollen, Boomkwekerij en Fruit, Lisse (Netherlands); Kreuk, N.; Kok, M. [DLV Plant, Wageningen (Netherlands)

    2005-11-15

    The main purpose of this demo was to show that during the storage season for tulip bulbs, relatively much energy and money can be saved by circulating bulbs well below the general standard of 500 m{sup 3} air/hour/m{sup 3}. To this end, two storage walls were placed in a cold store. In one of the stacked crates the circulation amount was reduced by means of a frequency control, whereas in the other one an on/off control was used. The energy meters were read three times per week for both set-ups [Dutch] Hoofddoel van deze demo was te demonstreren dat er gedurende het bewaarseizoen voor tulpenbollen relatief veel energie en geld bespaard kan worden door ruim onder de algemene norm van 500 m{sup 3} lucht/uur/m{sup 3} bollen te circuleren. Hiertoe zijn in een bewaarcel twee bewaarwanden opgesteld. In de ene kistenstapeling is de circulatiehoeveelheid teruggebracht d.m.v. een frequentieregeling, in de andere d.m.v. van een aan/uit regeling. De energiemeterstanden werden voor elke opstelling 3 maal per week bijgehouden.

  1. Prevalence of zinc deficiency among primary school children in a poor peri-urban informal settlement in South Africa

    Directory of Open Access Journals (Sweden)

    Folake O. Samuel

    2010-05-01

    Opsomming Die doel van hierdie dwarsdeursnitstudie was die bepaling van die risiko van ’n sinktekort in ’n ewekansige steekproef van 7 tot 11 jaar-oue kinders, woonagtig in ’n arm, voorstedelike informele woonbuurt in Suid Afrika. Dieetinnames van 149 respondente is geëvalueer deur 24-uur herroep en kwantitatiewe voedselfrekwensie vraelyste. Antropometriese en biochemiese indikatore van ’n kleiner steekproef van 113 is ook bepaal. Beskrywende statistiek, analise van variansie en Pearsonkorrelasies is bepaal deur die Statistical Package for Social Sciences, uitgawe 14.0. Antropometriese data is geanaliseer deur die statistiese program, Anthro plus, uitgawe 1.0.2, van die Wêreld Gesondheid Organisasie. Dieetdata is met behulp van FoodFinder® uitgawe 3 geanaliseer. Die gemiddelde ouderdom van die kinders was 9.0±1.1 jaar. Min sinkryke voedselbronne is in die hoofsaaklik plantryke dieet waargeneem. Die gemiddelde sinkinname was 4.6±2.2 mg/dag en die gemiddelde serumsinkwaarde was 66.4±21.5 µg/dL, met 46% van die kinders se waardes onder die 70 µg/dL afsnypunt. Die bevindings dui op ’n hoë risiko vir sinktekort en suboptimale sinkstatus vir die meerderheid van hierdie kinders, moontlik as gevolg van die swak inname van voedselbronne met hoë biobeskikbare sink, wat gewoonlik ’n direkte gevolg van armoede en huishoudelike voedsel insekuriteit is.

  2. Sustainable Energy for All. Inaugural speech; Een duurzame energievoorziening voor iedereen. Intreerede

    Energy Technology Data Exchange (ETDEWEB)

    Van Wijk, A.J.M.

    2011-12-07

    According to the author, there is no energy crisis; nor is there an energy shortage. Three observations illustrate this proposition: (1) We are wasting about 98% of our energy; (2) In one hour, the earth receives more energy from the sun than we consume worldwide in one year; and (3) sustainable energy is all around us. Next, the observations are elaborated and a plan is launched to set up a Green Campus: a living lab, an inspiring place where businesses and university can meet and a place where everyone can get an impression of the energy systems of the future. This way the author is hoping to take a next, important step in the realization of his dream, which is a sustainable energy system for all [Dutch] De auteur stelt dat er geen energiecrisis, geen energietekort is. Drie observaties illustreren deze stelling: (1) We verspillen ruwweg 98% van onze energie; (2) In een uur ontvangt de aarde meer energie van de zon, dan we wereldwijd in een jaar verbruiken; en (3) Duurzame energie is overal rond om ons heen. Vervolgens worden de observaties toegelicht en een plan gelanceerd om een Green Campus op te zetten: een living lab, een inspirerende plek waar bedrijven en universiteit elkaar ontmoeten en een plek waar een ieder een beeld kan krijgen op de energiesystemen van de toekomst. Daarmee hoopt de auteur een volgende en belangrijke stap te zetten in de realisatie van zijn droom, een duurzame energievoorziening voor iedereen.

  3. Dutch School in Geneva

    CERN Multimedia

    2011-01-01

    The Dutch School in Geneva organizes Dutch education for children in the primary and secondary school. For the school year 2011-2012 the Dutch School in Geneva is looking for qualified part time teachers Dutch for the primary and secondary school. If you are interested, please send your application and curriculum vitae in Dutch by email to the NTC coordinator, Mrs. Anne Saeys (anne.saeys@free.fr). More info : www.ntcgeneve.info De vereniging Nederlandse Taal en Cultuur De Taalfontein, kortweg NTC Genève, is een oudervereniging, die tot doel heeft de Nederlandse taal en de Nederlandse en Vlaamse cultuur in de regio Genève te stimuleren. Dit geschiedt d.m.v. het organiseren van Nederlandse les voor leerlingen zowel in het basisonderwijs als het voortgezet onderwijs. Voor het volgende schooljaar zoekt NTC parttime docenten (M/V) vanaf 2 uur per week, zowel voor het Primair Onderwijs als voor het Voortgezet Onderwijs, met name voor de IB-opleiding. Voor het Primair Onderwijs dienen ge&...

  4. The effects of fatigue and the post-concussion syndrome on executive functioning in traumatic brain injury and healthy comparisons

    Directory of Open Access Journals (Sweden)

    Jessica D. Fry

    2010-11-01

    Opsomming In hierdie studie is gedragsmanifestering in individue met gekompromitteerde uitvoerende funksionering, met inbegrip van perseverasie en verminderde induktiewe redenering, op die Wisconsin-kaartsorteringstoets (WCST, bestudeer. Die waarneming dat prestasie deur uitputting beïnvloed word in sowel normale populasies as dié met kopbeserings het implikasies vir gesondheidsorgpersoneel wat by rehabilitasie en assessering betrokke is. ’n Uitputtingstoestand is gemanipuleer vir 15 matig ernstige individue met traumatiese kopbeserings (TKB vir die duur van ’n drie uur lange toetssessie. ’n Vergelykingsmonster van 15 deelnemers met geen geskiedenis van kopbeserings is deur dieselfde metodologie uitgeput. Alle uitgeputte deelnemers (met en sonder TKB het ’n neiging na verhoogde vlakke van perseverasie en verminderde induktiewe redenering op die WCST getoon. Die impak van uitputting op hoëvlak-funksionering is dus verreikend, selfs in gevalle waar geen kopbesering opgedoen is nie. Die bevinding ondersteun suboptimale prestasie in kognitiewe vaardighede, en spesifiek in uitvoerende beheer, wat dikwels onder uitgeputte mense gevind word. Hierdie bevindinge is van belang vir die manier waarop rehabilitasie-intervensies en regsgeneeskundige assesserings gestruktureer word. Die volgorde van toetse, die interpretasie daarvan en die rusperiodes moet duidelik in assesseringsverslae en rehabilitasiesessies aangetoon en geïnterpreteer word.

  5. Eesti õpetajate roll laste internetikasutuse sotsiaalses vahendamises

    Directory of Open Access Journals (Sweden)

    Kadri Soo

    2015-11-01

    Full Text Available Õpetajatel on oluline roll laste ettevalmistamisel internetimaailmas toimetulekuks. Artiklis analüüsitakse Eesti õpetajate tegevust 9–16aastaste laste internetikasutuse sotsiaalses vahendamises, mille mõõtmiseks kasutati kaheksat tunnust EU Kids Online’i uuringust. Tulemused näitavad, et enamik Eesti õpetajatest on õpilaste internetikasutust sotsiaalselt vahendanud: üksnes 13% lastest ei suutnud meenutada, et nad oleks õpetajatelt kunagi juhiseid või informatsiooni saanud. Peamised erinevused Eesti õpetajate tegevuses ilmnesid keele ja asula suuruse puhul. Uuring lubab väita, et eesti keelt rääkivate ja väikestest asulatest pärit laste õpetajad vahendavad laste internetitegevusi aktiivsemalt ja mitmekülgsemalt ning pakuvad internetiohtude korral rohkem nõuandeid. See, kuidas on õpetajate tegevus ja laste kokkupuude internetiohtudega omavahel seotud, erineb vanuseja keelerühmiti. Internetis kahju kogemine ei ole seotud õpetajatepoolse sotsiaalse vahendamisega.  Summary

  6. New evidence of a mitochondrial genetic background paradox: Impact of the J haplogroup on the A3243G mutation

    Directory of Open Access Journals (Sweden)

    Pennarun Erwann

    2008-05-01

    Full Text Available Abstract Background The A3243G mutation in the tRNALeu gene (UUR, is one of the most common pathogenic mitochondrial DNA (mtDNA mutations in France, and is associated with highly variable and heterogeneous disease phenotypes. To define the relationships between the A3243G mutation and mtDNA backgrounds, we determined the haplogroup affiliation of 142 unrelated French patients – diagnosed as carriers of the A3243G mutation – by control-region sequencing and RFLP survey of their mtDNAs. Results The analysis revealed 111 different haplotypes encompassing all European haplogroups, indicating that the 3243 site might be a mutational hot spot. However, contrary to previous findings, we observed a statistically significant underepresentation of the A3243G mutation on haplogroup J in patients (p = 0.01, OR = 0.26, C.I. 95%: 0.08–0.83, suggesting that might be due to a strong negative selection at the embryo or germ line stages. Conclusion Thus, our study supports the existence of mutational hotspot on mtDNA and a "haplogroup J paradox," a haplogroup that may increase the expression of mtDNA pathogenic mutations, but also be beneficial in certain environmental contexts.

  7. MELAS Syndrome and Kidney Disease Without Fanconi Syndrome or Proteinuria: A Case Report.

    Science.gov (United States)

    Rudnicki, Michael; Mayr, Johannes A; Zschocke, Johannes; Antretter, Herwig; Regele, Heinz; Feichtinger, René G; Windpessl, Martin; Mayer, Gert; Pölzl, Gerhard

    2016-12-01

    Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS syndrome) represents one of the most frequent mitochondrial disorders. The majority of MELAS cases are caused by m.3243A>G mutation in the mitochondrial MT-TL1 gene, which encodes the mitochondrial tRNA Leu(UUR) . Kidney involvement usually manifests as Fanconi syndrome or focal segmental glomerulosclerosis. We describe a patient with MELAS mutation, cardiomyopathy, and chronic kidney disease without Fanconi syndrome, proteinuria, or hematuria. While the patient was waitlisted for heart transplantation, her kidney function deteriorated from an estimated glomerular filtration rate of 33 to 20mL/min/1.73m 2 within several months. Kidney biopsy was performed to distinguish decreased kidney perfusion from intrinsic kidney pathology. Histologic examination of the biopsy specimen showed only a moderate degree of tubular atrophy and interstitial fibrosis, but quantitative analysis of the m.3243A>G mitochondrial DNA mutation revealed high heteroplasmy levels of 89% in the kidney. Functional assessment showed reduced activity of mitochondrial enzymes in kidney tissue, which was confirmed by immunohistology. In conclusion, we describe an unusual case of MELAS syndrome with chronic kidney disease without apparent proteinuria or tubular disorders associated with Fanconi syndrome, but widespread interstitial fibrosis and a high degree of heteroplasmy of the MELAS specific mutation and low mitochondrial activity in the kidney. Copyright © 2016 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.

  8. Cerebral hyperperfusion and decreased cerebrovascular reactivity correlate with neurologic disease severity in MELAS.

    Science.gov (United States)

    Rodan, L H; Poublanc, J; Fisher, J A; Sobczyk, O; Wong, T; Hlasny, E; Mikulis, D; Tein, I

    2015-05-01

    To study the mechanisms underlying stroke-like episodes (SLEs) in MELAS syndrome. We performed a case control study in 3 siblings with MELAS syndrome (m.3243A>G tRNA(Leu(UUR))) with variable % mutant mtDNA in blood (35 to 59%) to evaluate regional cerebral blood flow (CBF) and arterial cerebrovascular reactivity (CVR) compared to age- and sex-matched healthy study controls and a healthy control population. Subjects were studied at 3T MRI using arterial spin labeling (ASL) to measure CBF; CVR was measured as a change in % Blood Oxygen Level Dependent signal (as a surrogate of CBF) to repeated 10 mmHg step increase in arterial partial pressure of CO2 (PaCO2). MELAS siblings had decreased CVR (p ≤ 0.002) and increased CBF (p MELAS disease severity and mutation load were inversely correlated with Interictal CVR and directly correlated with frontal CBF. These metrics offer further insight into the cerebrovascular hemodynamics in MELAS syndrome and may serve as noninvasive prognostic markers to stratify risk for SLEs. Class III. Copyright © 2015 © Elsevier B.V. and Mitochondria Research Society. Published by Elsevier B.V. All rights reserved.

  9. Advanced laser sensing receiver concepts based on FPA technology

    International Nuclear Information System (INIS)

    Jacobson, Phillip L.; Petrin, Roger R.; Jolin, John L.; Foy, Bernard R.; Lowrance, J.L.; Renda, George

    2002-01-01

    The ultimate performance of any remote sensor is ideally governed by the hardware signal-to-noise capability and allowed signal-averaging time. In real-world scenarios, this may not be realizable and the limiting factors may suggest the need for more advanced capabilities. Moving from passive to active remote sensors offers the advantage of control over the illumination source, the laser. Added capabilities may include polarization discrimination, instantaneous imaging, range resolution, simultaneous multi-spectral measurement, or coherent detection. However, most advanced detection technology has been engineered heavily towards the straightforward passive sensor requirements, measuring an integrated photon flux. The need for focal plane array technology designed specifically for laser sensing has been recognized for some time, but advances have only recently made the engineering possible. This paper will present a few concepts for laser sensing receiver architectures, the driving specifications behind those concepts, and test/modeling results of such designs.

  10. Early onset diabetes-genetic and hormonal analysis in pakistan population

    International Nuclear Information System (INIS)

    Wahid, M.; Kamran, M.

    2016-01-01

    Background: Mitochondrial DNA mutation and hormonal imbalance is involved in the pathogenesis of early onset diabetes but data is lacking in Pakistani population. The study was planned to delineate the clinical presentation of early onset diabetes with possible hormonal and genetic etiological factors and aascertain the possible etiological role of insulin and glucagon in these patients either on oral hypoglycaemic or subcutaneous insulin therapy. Methods: Retrospective, analytical case control study with conventional sampling technique carried at Centre for Research in Experimental and Applied Medicine (CREAM) affiliated with the department of Biochemistry and Molecular Biology, Army Medical College Rawalpindi from Dec 2006 to July 2011. Study included the patients (20-35 years of age) with early onset diabetes on oral hypoglycemic (n=240), insulin therapy (n=280), and compared with non-diabetic healthy controls (n=150). A fragment surrounding tRNALeu (UUR) gene was amplified by AmpliTaq from mtDNA which was extracted from peripheral blood leucocytes. Then it was subjected to restriction endonucleases, ApaI for A3242G mutation and HaeIII for G3316A mutation detection. Plasma glucose, glycosylated Hb, osmolality, insulin and glucagon levels along with ABGs analysis was also done. Results: Non diabetic controls comprised of 51% males and 49% females, diabetics on oral hypoglycemic 60% males and 40 % females and on insulin therapy 54% males and 46% females. Insulin dependent diabetics had statistically significant hyperglucagonemia, acidemia and bicarbonate deficit. MtDNA A3242G and G3316A mutations were not detected. Conclusion: relative hyperglucagonemia and acidemia in Insulin dependent diabetics was a potent threat leading to DKA. The absence of two mtDNA mutations in ND1 gene rules out the possibility of involvement of these mutations in early onset diabetes in Pakistani population. (author)

  11. Cambio: a file format translation and analysis application for the nuclear response emergency community

    International Nuclear Information System (INIS)

    Lasche, George P.

    2009-01-01

    Cambio is an application intended to automatically read and display any spectrum file of any format in the world that the nuclear emergency response community might encounter. Cambio also provides an analysis capability suitable for HPGe spectra when detector response and scattering environment are not well known. Why is Cambio needed: (1) Cambio solves the following problem - With over 50 types of formats from instruments used in the field and new format variations appearing frequently, it is impractical for every responder to have current versions of the manufacturer's software from every instrument used in the field; (2) Cambio converts field spectra to any one of several common formats that are used for analysis, saving valuable time in an emergency situation; (3) Cambio provides basic tools for comparing spectra, calibrating spectra, and isotope identification with analysis suited especially for HPGe spectra; and (4) Cambio has a batch processing capability to automatically translate a large number of archival spectral files of any format to one of several common formats, such as the IAEA SPE or the DHS N42. Currently over 540 analysts and members of the nuclear emergency response community worldwide are on the distribution list for updates to Cambio. Cambio users come from all levels of government, university, and commercial partners around the world that support efforts to counter terrorist nuclear activities. Cambio is Unclassified Unlimited Release (UUR) and distributed by internet downloads with email notifications whenever a new build of Cambio provides for new formats, bug fixes, or new or improved capabilities. Cambio is also provided as a DLL to the Karlsruhe Institute for Transuranium Elements so that Cambio's automatic file-reading capability can be included at the Nucleonica web site.

  12. Parallel origins of duplications and the formation of pseudogenes in mitochondrial DNA from parthenogenetic lizards (Heteronotia binoei; Gekkonidae).

    Science.gov (United States)

    Zevering, C E; Moritz, C; Heideman, A; Sturm, R A

    1991-11-01

    Analysis of mitochondrial DNAs (mtDNAs) from parthenogenetic lizards of the Heteronotia binoei complex with restriction enzymes revealed an approximately 5-kb addition present in all 77 individuals. Cleavage site mapping suggested the presence of a direct tandem duplication spanning the 16S and 12S rRNA genes, the control region and most, if not all, of the gene for the subunit 1 of NADH dehydrogenase (ND1). The location of the duplication was confirmed by Southern hybridization. A restriction enzyme survey provided evidence for modifications to each copy of the duplicated sequence, including four large deletions. Each gene affected by a deletion was complemented by an intact version in the other copy of the sequence, although for one gene the functional copy was heteroplasmic for another deletion. Sequencing of a fragment from one copy of the duplication which encompassed the tRNA(leu)(UUR) and parts of the 16S rRNA and ND1 genes, revealed mutations expected to disrupt function. Thus, evolution subsequent to the duplication event has resulted in mitochondrial pseudogenes. The presence of duplications in all of these parthenogens, but not among representatives of their maternal sexual ancestors, suggests that the duplications arose in the parthenogenetic form. This provides the second instance in H. binoei of mtDNA duplication associated with the transition from sexual to parthenogenetic reproduction. The increased incidence of duplications in parthenogenetic lizards may be caused by errors in mtDNA replication due to either polyploidy or hybridity of their nuclear genomes.

  13. Detection of Deafness-Causing Mutations in the Greek Mitochondrial Genome

    Directory of Open Access Journals (Sweden)

    Haris Kokotas

    2011-01-01

    Full Text Available Mitochondrion harbors its own DNA, known as mtDNA, encoding certain essential components of the mitochondrial respiratory chain and protein synthesis apparatus. mtDNA mutations have an impact on cellular ATP production and many of them are undoubtedly a factor that contributes to sensorineural deafness, including both syndromic and non-syndromic forms. Hot spot regions for deafness mutations are the MTRNR1 gene, encoding the 12S rRNA, the MTTS1 gene, encoding the tRNA for Ser(UCN, and the MTTL1 gene, encoding the tRNA for Leu(UUR. We investigated the impact of mtDNA mutations in the Greek hearing impaired population, by testing a cohort of 513 patients suffering from childhood onset prelingual or postlingual, bilateral, sensorineural, syndromic or non-syndromic hearing loss of any degree for six mitochondrial variants previously associated with deafness. Screening involved the MTRNR1 961delT/insC and A1555G mutations, the MTTL1 A3243G mutation, and the MTTS1 A7445G, 7472insC and T7510C mutations. Although two patients were tested positive for the A1555G mutation, we failed to identify any subject carrying the 961delT/insC, A3243G, A7445G, 7472insC, or T7510C mutations. Our findings strongly support our previously raised conclusion that mtDNA mutations are not a major risk factor for sensorineural deafness in the Greek population.

  14. MELAS syndrome: Clinical manifestations, pathogenesis, and treatment options.

    Science.gov (United States)

    El-Hattab, Ayman W; Adesina, Adekunle M; Jones, Jeremy; Scaglia, Fernando

    2015-01-01

    Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome is one of the most frequent maternally inherited mitochondrial disorders. MELAS syndrome is a multi-organ disease with broad manifestations including stroke-like episodes, dementia, epilepsy, lactic acidemia, myopathy, recurrent headaches, hearing impairment, diabetes, and short stature. The most common mutation associated with MELAS syndrome is the m.3243A>G mutation in the MT-TL1 gene encoding the mitochondrial tRNA(Leu(UUR)). The m.3243A>G mutation results in impaired mitochondrial translation and protein synthesis including the mitochondrial electron transport chain complex subunits leading to impaired mitochondrial energy production. The inability of dysfunctional mitochondria to generate sufficient energy to meet the needs of various organs results in the multi-organ dysfunction observed in MELAS syndrome. Energy deficiency can also stimulate mitochondrial proliferation in the smooth muscle and endothelial cells of small blood vessels leading to angiopathy and impaired blood perfusion in the microvasculature of several organs. These events will contribute to the complications observed in MELAS syndrome particularly the stroke-like episodes. In addition, nitric oxide deficiency occurs in MELAS syndrome and can contribute to its complications. There is no specific consensus approach for treating MELAS syndrome. Management is largely symptomatic and should involve a multidisciplinary team. Unblinded studies showed that l-arginine therapy improves stroke-like episode symptoms and decreases the frequency and severity of these episodes. Additionally, carnitine and coenzyme Q10 are commonly used in MELAS syndrome without proven efficacy. Copyright © 2015 Elsevier Inc. All rights reserved.

  15. Metabolically induced heteroplasmy shifting and L-arginine treatment reduce the energetic defect in a neuronal-like model of MELAS

    Science.gov (United States)

    Desquiret-Dumas, Valerie; Gueguen, Naig; Barth, Magalie; Chevrollier, Arnaud; Hancock, Saege; Wallace, Douglas C; Amati-Bonneau, Patrizia; Henrion, Daniel; Bonneau, Dominique; Reynier, Pascal; Procaccio, Vincent

    2012-01-01

    The m.3243A>G variant in the mitochondrial tRNALeu (UUR) gene is a common mitochondrial DNA (mtDNA) mutation. Phenotypic manifestations depend mainly on the heteroplasmy, i.e. the ratio of mutant to normal mtDNA copies. A high percentage of mutant mtDNA is associated with a severe, life-threatening neurological syndrome known as MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes). MELAS is described as a neurovascular disorder primarily affecting the brain and blood vessels, but the pathophysiology of the disease is poorly understood. We developed a series of cybrid cell lines at two different mutant loads: 70% and 100% in the nuclear background of a neuroblastoma cell line (SH-SY5Y). We investigated the impact of the mutation on the metabolism and mitochondrial respiratory chain activity of the cybrids. The m.3243A>G mitochondrial mutation induced a metabolic switch towards glycolysis in the neuronal cells and produced severe defects in respiratory chain assembly and activity. We used two strategies to compensate for the biochemical defects in the mutant cells: one consisted of lowering the glucose content in the culture medium, and the other involved the addition of L-arginine. The reduction of glucose significantly shifted the 100% mutant cells towards the wild-type, reaching a 90% mutant level and restoring respiratory chain complex assembly. The addition of L-arginine, a nitric oxide (NO) donor, improved complex I activity in the mutant cells in which the defective NO metabolism had led to a relative shortage of NO. Thus, metabolically induced heteroplasmy shifting and L-arginine therapy may constitute promising therapeutic strategies against MELAS. PMID:22306605

  16. Random insertion and gene disruption via transposon mutagenesis of Ureaplasma parvum using a mini-transposon plasmid.

    Science.gov (United States)

    Aboklaish, Ali F; Dordet-Frisoni, Emilie; Citti, Christine; Toleman, Mark A; Glass, John I; Spiller, O Brad

    2014-11-01

    While transposon mutagenesis has been successfully used for Mycoplasma spp. to disrupt and determine non-essential genes, previous attempts with Ureaplasma spp. have been unsuccessful. Using a polyethylene glycol-transformation enhancing protocol, we were able to transform three separate serovars of Ureaplasma parvum with a Tn4001-based mini-transposon plasmid containing a gentamicin resistance selection marker. Despite the large degree of homology between Ureaplasma parvum and Ureaplasma urealyticum, all attempts to transform the latter in parallel failed, with the exception of a single clinical U. urealyticum isolate. PCR probing and sequencing were used to confirm transposon insertion into the bacterial genome and identify disrupted genes. Transformation of prototype serovar 3 consistently resulted in transfer only of sequence between the mini-transposon inverted repeats, but some strains showed additional sequence transfer. Transposon insertion occurred randomly in the genome resulting in unique disruption of genes UU047, UU390, UU440, UU450, UU520, UU526, UU582 for single clones from a panel of screened clones. An intergenic insertion between genes UU187 and UU188 was also characterised. Two phenotypic alterations were observed in the mutated strains: Disruption of a DEAD-box RNA helicase (UU582) altered growth kinetics, while the U. urealyticum strain lost resistance to serum attack coincident with disruption of gene UUR10_137 and loss of expression of a 41 kDa protein. Transposon mutagenesis was used successfully to insert single copies of a mini-transposon into the genome and disrupt genes leading to phenotypic changes in Ureaplasma parvum strains. This method can now be used to deliver exogenous genes for expression and determine essential genes for Ureaplasma parvum replication in culture and experimental models. Copyright © 2014 Elsevier GmbH. All rights reserved.

  17. L-Arginine Affects Aerobic Capacity and Muscle Metabolism in MELAS (Mitochondrial Encephalomyopathy, Lactic Acidosis and Stroke-Like Episodes Syndrome.

    Directory of Open Access Journals (Sweden)

    Lance H Rodan

    Full Text Available To study the effects of L-arginine (L-Arg on total body aerobic capacity and muscle metabolism as assessed by (31Phosphorus Magnetic Resonance Spectroscopy ((31P-MRS in patients with MELAS (Mitochondrial Encephalomyopathy with Lactic Acidosis and Stroke-like episodes syndrome.We performed a case control study in 3 MELAS siblings (m.3243A>G tRNA(leu(UUR in MTTL1 gene with different % blood mutant mtDNA to evaluate total body maximal aerobic capacity (VO(2peak using graded cycle ergometry and muscle metabolism using 31P-MRS. We then ran a clinical trial pilot study in MELAS sibs to assess response of these parameters to single dose and a 6-week steady-state trial of oral L-Arginine.At baseline (no L-Arg, MELAS had lower serum Arg (p = 0.001. On 3(1P-MRS muscle at rest, MELAS subjects had increased phosphocreatine (PCr (p = 0.05, decreased ATP (p = 0.018, and decreased intracellular Mg(2+ (p = 0.0002 when compared to matched controls. With L-arginine therapy, the following trends were noted in MELAS siblings on cycle ergometry: (1 increase in mean % maximum work at anaerobic threshold (AT (2 increase in % maximum heart rate at AT (3 small increase in VO(2peak. On (31P-MRS the following mean trends were noted: (1 A blunted decrease in pH after exercise (less acidosis (2 increase in Pi/PCr ratio (ADP suggesting increased work capacity (3 a faster half time of PCr recovery (marker of mitochondrial activity following 5 minutes of moderate intensity exercise (4 increase in torque.These results suggest an improvement in aerobic capacity and muscle metabolism in MELAS subjects in response to supplementation with L-Arg. Intramyocellular hypomagnesemia is a novel finding that warrants further study.Class III evidence that L-arginine improves aerobic capacity and muscle metabolism in MELAS subjects.ClinicalTrials.gov NCT01603446.

  18. Genetic basis of endocrine pathology

    Directory of Open Access Journals (Sweden)

    T.V. Sorokman

    2017-05-01

    Full Text Available The purpose of the review was analysis of literature data relating to the molecular genetic basis and diagnosis of endocrine pathology. We searched for published and unpublished researches using Pubmed as the search engine by the keywords: ‘genes’, ‘endocrine diseases’, ‘molecular diagnostics’, ‘prohormones’, ‘nuclear receptors and transcription factors’, taking into consideration studies conducted over the last 10 years, citation review of relevant primary and review articles, conference abstracts, personal files, and contact with expert informants. The criterion for the selection of articles for the study was based on their close relevance to the topic, thus out of 144 analyzed articles, the findings of the researchers covered in 32 articles were crucial. The described nosologies presented various heredi­tary forms of hypopituitarism, disturbances of steroid hormone biosynthesis, abnormal gender formation, monogenic forms of diabetes mellitus, endocrine tumors, etc. Pathology is identified that is associated with a mutation of genes encoding protein prohormones, receptors, steroid biosynthesis enzymes, intracellular signaling molecules, transport proteins, ion channels, and transcription factors. Among the endocrine diseases associated with defects in genes encoding protein prohormones, the defects of the GH1 gene are most common, the defects in the gene CYP21A2 (21-hydroxylase are among diseases associated with defects in genes encoding enzymes. More often mutations of genes encoding proteins belong to the class of G-protein coupled receptors. Most of the mutations associated with MEN-2A are concentrated in the rich cysteine region of the Ret receptor. More than 70 monogenic syndromes are known, in which there is a marked tolerance to glucose and some form of diabetes mellitus is diagnosed, diabetes mellitus caused by mutation of the mitochondrial gene (mutation tRNALeu, UUR is also detected. Of all the monogenic forms of

  19. L-Arginine Affects Aerobic Capacity and Muscle Metabolism in MELAS (Mitochondrial Encephalomyopathy, Lactic Acidosis and Stroke-Like Episodes) Syndrome.

    Science.gov (United States)

    Rodan, Lance H; Wells, Greg D; Banks, Laura; Thompson, Sara; Schneiderman, Jane E; Tein, Ingrid

    2015-01-01

    To study the effects of L-arginine (L-Arg) on total body aerobic capacity and muscle metabolism as assessed by (31)Phosphorus Magnetic Resonance Spectroscopy ((31)P-MRS) in patients with MELAS (Mitochondrial Encephalomyopathy with Lactic Acidosis and Stroke-like episodes) syndrome. We performed a case control study in 3 MELAS siblings (m.3243A>G tRNA(leu(UUR)) in MTTL1 gene) with different % blood mutant mtDNA to evaluate total body maximal aerobic capacity (VO(2peak)) using graded cycle ergometry and muscle metabolism using 31P-MRS. We then ran a clinical trial pilot study in MELAS sibs to assess response of these parameters to single dose and a 6-week steady-state trial of oral L-Arginine. At baseline (no L-Arg), MELAS had lower serum Arg (p = 0.001). On 3(1)P-MRS muscle at rest, MELAS subjects had increased phosphocreatine (PCr) (p = 0.05), decreased ATP (p = 0.018), and decreased intracellular Mg(2+) (p = 0.0002) when compared to matched controls. With L-arginine therapy, the following trends were noted in MELAS siblings on cycle ergometry: (1) increase in mean % maximum work at anaerobic threshold (AT) (2) increase in % maximum heart rate at AT (3) small increase in VO(2peak). On (31)P-MRS the following mean trends were noted: (1) A blunted decrease in pH after exercise (less acidosis) (2) increase in Pi/PCr ratio (ADP) suggesting increased work capacity (3) a faster half time of PCr recovery (marker of mitochondrial activity) following 5 minutes of moderate intensity exercise (4) increase in torque. These results suggest an improvement in aerobic capacity and muscle metabolism in MELAS subjects in response to supplementation with L-Arg. Intramyocellular hypomagnesemia is a novel finding that warrants further study. Class III evidence that L-arginine improves aerobic capacity and muscle metabolism in MELAS subjects. ClinicalTrials.gov NCT01603446.

  20. Ventilation rates in classrooms and performances of students. Preliminary study on their association; Ventilatiedebieten in klaslokalen en prestaties van scholieren

    Energy Technology Data Exchange (ETDEWEB)

    Shaughnessy, R.J. [The University of Tulsa, Tulsa, OK (United States); Haverinen-Shaughnessy, U.; Nevalainen, A. [Department of Environmental Health, National Public Health Institute, Kuopio (Finland); Moschandreas, D. [Department of Chemical and Environmental Engineering, Illinois Institute of Technology, Chicago, IL (United States)

    2007-10-15

    (CO2) in het klaslokaal. De prestaties van scholieren worden geinventariseerd aan de hand van gestandaardiseerde tests die op jaarlijkse basis worden uitgereikt. Voor bepaling van de hoeveelheid ventilatie in elke ruimte worden CO2-concentraties gebruikt. De CO2-concentraties zijn gedurende 4-5 uur op een typische schooldag gemeten in klaslokalen van groep 8, op 54 basisscholen binnen een schooldistrict in de Verenigde Staten. Resultaten van dit inleidend onderzoek leveren een significant (P < 0,10) verband op tussen het ventilatiedebiet in klaslokalen en de resultaten van scholieren op rekentests. De resultaten duiden daarnaast aan dat niet-lineaire effecten moeten worden overwogen voor een betere beschrijving van het verband. Een grotere steekproef is benodigd om meer definitieve conclusies te kunnen trekken.

  1. Storage ring free electron laser, pulse propagation effects and microwave type instabilities

    Energy Technology Data Exchange (ETDEWEB)

    Dattoli, G.; Mezi, L.; Renieri, A. [ENEA, Divisione Fisica Applicata, Centro Ricerche Frascati, Frascati, RM (Italy); Migliorati, M. [Rome Univ. La Sapienza, Rome (Italy). Dipt. di Energetica

    2000-07-01

    It has been developed a dynamical model accounting for the storage Ring Free Electron Laser evolution including pulse propagation effects and e-beam instabilities of microwave type. It has been analyzed the general conditions under which the on set of the laser may switch off the instability and focus everybody attention on the interplay between cavity mismatch, laser pulsed behavior and e-beam instability dynamics. Particular attention is also devoted to the laser operation in near threshold conditions, namely at an intracavity level just enough to counteract the instability, that show in this region new and interesting effects arises. [Italian] Si sviluppa un modello dinamico per la descrizione dell'evoluzione di un laser ad elettroni liberi in anello di accumulazione con l'inclusione di effetti di propagazione d'impulso e di instabilita' a microonda. Si analizzano le condizioni per le quali l'instaurarsi dell'operazione laser puo' spegnere l'instabilita' e si focalizza l'attenzione sulla connessione fra desincronismo della cavita', comportamento pulsato del laser e comportamento instabile del fascio di elettroni: si analizza in particolare l'operazione laser quando il guadagno e' prossimo alle perdite della cavita' e si osservano effetti particolarmente interessanti.

  2. Characteristics of the FEL project for the MUH experiment; Stato del progetto FEL per l`esperimeto MUH

    Energy Technology Data Exchange (ETDEWEB)

    Ciocci, F.; Doria, A.; Fascetti, M.; Gallerano, G.P.; Giannessi, L.; Giovenale, E.; Messina, G.; Picardi, L.; Renieri, A.; Ronci, G.; Ronsivalle, C.; Vignati, A. [ENEA, Centro Ricerche Frascati, Rome (Italy). Dip. Innovazione

    1999-01-01

    The design characteristics of a compact Free Electron Laser (FEL) operating in the far infrared spectral range between 200 and 600 {mu}m are presented in this report. The device can be employed in a fundamental physics experiment to be performed in collaboration with INFN-Trieste and the Paul Sherrer Institute- Villigen. Spectroscopic measurements in the above spectral region will allow one to determine the energy difference between the levels 3D-3P in the {mu}P system with great accuracy. [Italiano] In questo rapporto vengono presentate le caratteristiche di progetto di un Laser ad Elettroni Liberi (FEL) compatto operante nel lontano infrarosso a lunghezze d`onda comprese tra 200 e 600 {mu}m. Tale laser potra` essere impiegato in un esperimento di fisica fondamentale su idrogeno muonico in collaborazione con INFN-Trieste ed il Paul Sherrer Institute-Villigen. Le misure spettroscopiche nella regione spettrale del lontano infrarosso consentiranno di determinare con grande accuratezza la differenza di energia dei livelli 3D-3P nel sistema {mu}P. Attraverso la misura di questa transizione sara` possibile effettuare un test delle correzioni di Meccanica Quantistica (QED) alle energie di legame, migliorando di un ordine di grandezza l`accuratezza della misura della polarizzazione del vuoto.

  3. Health status of an elderly population in Sharpeville, South Africa

    Directory of Open Access Journals (Sweden)

    Wilna H Oldewage-Theron

    2008-11-01

    Full Text Available The objective of this cross-sectional study was a comprehensive nutrition and health assessment to provide a basis for future intervention strategies for an elderly population attending a day-care centre. Socio-demographic, health and 24-hour recall dietary intake questionnaires were administered and anthropometric and biochemical measurements taken. The results indicate that the majority of respondents had an income of between R501 and R1 000 (South African rand per month and most of them reported an occasional lack of funds to meet basic household needs, confirming the presence of food insecurity. Daily dietary intakes (mean±Standard Deviation [SD] of the women were 5 395±2 946 kJ energy, 47±27 g protein, 28±21 g fat and 196±123 g carbohydrates compared to 8 641±3 799 kJ, 86±48 g, 49±32 g and 301±139 g of the men, respectively. The majority (83.6% of the women were overweight (body mass index [BMI] >25 or obese (BMI > 30 whilst 78% had a mid-upper arm circumference (MUAC of > 21.7 cm. Mean intakes of micronutrients were low in comparison to reference standards and serum zinc levels were suboptimal. Obesity, hypertension and raised total serum cholesterol levels indicated an increased risk for coronary heart disease. It can be concluded that a low income, household food insecurity and risk factors associated with malnutrition and non-communicable diseases were prevalent in this elderly population. Opsomming Die doelwit van hierdie dwarssnitstudie was ‘n omvattende bepaling van voeding- en gesondheidstatus om as basis te dien vir toekomstige intervensie-strategieë vir ’n groep bejaardes wat ’n dagsentrum besoek. Sosiodemografiese, gesondheid- en 24-uur herroep-dieetinname vraelyste is voltooi en antropometriese en biochemiese metings is geneem. Die resultate het bevestig dat die meerderheid respondente ‘n maandelikse inkomste van tussen R501 en R1 000 (Suid-Afrikaanse rand gehad het. Die meeste het ‘n geldtekort vir basiese

  4. Book Reviews

    Directory of Open Access Journals (Sweden)

    Redactie KITLV

    2008-12-01

    (Raul Pertierra Odd Arne Westad, Sophie Quinn-Judge (eds; The Third Indochina War; Conflict between China, Vietnam and Cambodia, 1972-79 (Vatthana Pholsena B. Bouman; Ieder voor zich en de Republiek voor ons allen; De logistiek achter de Indonesische Revolutie 1945-1950 (Harry A. Poeze Michel Gilquin; The Muslims of Thailand (Nathan Porath Tom Boellstorff; The gay archipelago; Sexuality and nation in Indonesia (Raquel Reyes Kathleen M. Adams; Art as politics; Re-crafting identities, tourism, and power in Tana Toraja, Indonesia (Dik Roth Aris Ananta, Evi Nurvidya Arifin, Leo Suryadinata; Emerging democracy in Indonesia (Henk Schulte Nordholt Casper Schuring; Abdulgani; 70 jaar nationalist van het eerste uur (Nico G. Schulte Nordholt Geoff Wade (ed. and transl.; Southeast Asia in the Ming Shi-lu; An open access resource (Heather Sutherland Alexander Horstmann, Reed L. Wadley (eds; Centering the margin; Agency and narrative in Southeast Asian Borderlands (Nicholas Tapp Marieke Brand, Henk Schulte Nordholt, Fridus Steijlen (eds; Indië verteld; Herinneringen, 1930-1950 (Jean Gelman Taylor Tin Maung Maung Than; State dominance in Myanmar; The political economy of industrialization (Sean Turnell Henk Schulte Nordholt, Ireen Hoogenboom (eds; Indonesian transitions (Robert Wessing In: Bijdragen tot de Taal-, Land- en Volkenkunde no. 163 (20075, no: 4, Leiden

  5. Darüşşifas Where Music Threapy was Practiced During Anatolian Seljuks and Ottomans

    Directory of Open Access Journals (Sweden)

    Gülşen Erdal

    2013-03-01

    Full Text Available AbstractMusic therapy, one of the oldest treatment methods known, dates back to thousands of years. Turks’ using music therapy practices in hospitals -Ottoman and Seljuk hospitals- built with appropriate acoustic in the treatment of mental disorders, utilizing the books which included the researches done by scientists such as İbni Sina, Razî, Farabî, Hasan Şuurî and in Gevrekzade Hasan Efendi in music therapy and improving music therapy practices exemplarily in the period of Ottomans and Seljukians is assessed as the first serious music therapy practices. Darüşşifa is one of the names given to medical and educational establishments which give people health service depending on practice and observation and treated patients in Turkish and Islamic world. Turks started various reconstruction activities following their settlement in Anatolia. Within a short period, they built several types of artifacts such as; caravansaries, madrasahs, mosques, darüşşifas. In Seljukian and Ottoman darüşşifas, medical subjects were taught according to researches and scientific principals, and surgeons were educated at medical madrasahs as well. Medical health care service was provided in those places. In this study, of darüşşifas where music therapy was practised the ones surviving today and having importance have been analyzed so as to emphasize how curative power of art history and music was used by Turkish people centuries ago. From this point of view, Kayseri Gevher Nesibe Tıp Medresesi (Medical madrasah (1206, Divriği Ulu Camii ve Darüşşifası (Mosque and Hospital (1228, Amasya Darüşşifası (1309, Fatih Darüşşifası (1470 Edirne Sultan II. Bayezid Darüşşifası (1488, Süleymaniye Tıp Medresesi and Şifahanesi (Medical Madrasah and Hospital (1556 have been examined in this study as the featured ones among the institutions where music therapy was practised.ÖzetMüziğin insanlar üzerinde bıraktığı psikolojik ve fiziksel etki

  6. Darüşşifas Where Music Threapy was Practiced During Anatolian Seljuks and Ottomans / Selçuklu ve Osmanlı Darüşşifalarında Müzikle Tedavi

    Directory of Open Access Journals (Sweden)

    Gülşen Erdal

    2013-03-01

    Full Text Available Abstract Music therapy, one of the oldest treatment methods known, dates back to thousands of years. Turks’ using music therapy practices in hospitals -Ottoman and Seljuk hospitals- built with appropriate acoustic in the treatment of mental disorders, utilizing the books which included the researches done by scientists such as İbni Sina, Razî, Farabî, Hasan Şuurî and in Gevrekzade Hasan Efendi in music therapy and improving music therapy practices exemplarily in the period of Ottomans and Seljukians is assessed as the first serious music therapy practices. Darüşşifa is one of the names given to medical and educational establishments which give people health service depending on practice and observation and treated patients in Turkish and Islamic world. Turks started various reconstruction activities following their settlement in Anatolia. Within a short period, they built several types of artifacts such as; caravansaries, madrasahs, mosques, darüşşifas. In Seljukian and Ottoman darüşşifas, medical subjects were taught according to researches and scientific principals, and surgeons were educated at medical madrasahs as well. Medical health care service was provided in those places. In this study, of darüşşifas where music therapy was practised the ones surviving today and having importance have been analyzed so as to emphasize how curative power of art history and music was used by Turkish people centuries ago. From this point of view, Kayseri Gevher Nesibe Tıp Medresesi (Medical madrasah (1206, Divriği Ulu Camii ve Darüşşifası (Mosque and Hospital (1228, Amasya Darüşşifası (1309, Fatih Darüşşifası (1470 Edirne Sultan II. Bayezid Darüşşifası (1488, Süleymaniye Tıp Medresesi and Şifahanesi (Medical Madrasah and Hospital (1556 have been examined in this study as the featured ones among the institutions where music therapy was practised. Özet Müziğin insanlar üzerinde bıraktığı psikolojik ve fiziksel

  7. Book Reviews

    Directory of Open Access Journals (Sweden)

    H.J.M. Claessen

    1990-04-01

    , Bernard Juillerat, Les enfants du sang: Société, reproduction et imaginaire en Nouvelle-Guinée, Paris: Editions de la Maison des Sciences de l’Homme, 1986, 569 pp. - M.A. Kagenaar, Aart G. Broek, Het Zilt van de Passaten; Caribische Letteren van Verzet; Essays. Haarlem: In de Knipscheer, 1988; 186 pp. - Peter Meel, Ben Scholtens, Louis Doedel, Surinaams vakbondsleider van het eerste uur; Een bronnenpublikatie. Paramaribo: Anton de Kom Universiteit van Suriname. 1987. 141 p. - Peter Meel, Nico Wijnen et al., A. de Kom, zijn strijd en ideeën, Amsterdam: Sranan Buku, 1989. 130 pp. - D.C. Mulder, A.A. Yewangoe, Theologia Crucis in Asia, Amsterdam, 1987. 352 pp. - Rien Ploeg, H.J.M. Claessen, Bronnen van macht; Over het gebruik van bronnen in het onderzoek naar de vroege staat, Leiden: ICA, 1987. 159 pp., J.G. Oosten (eds. - Rien Ploeg, H.J.M. Claessen, Over de politiek denkende en handelende mens; Een inleiding in de politieke antropologie, Assen/Maastricht: Van Gorcum, 1988. 168 pp. - Harry A. Poeze, L.F. Jansen, In deze halve gevangenis; Dagboek van mr dr L.F. Jansen, Batavia/Djakarta 1942-1945; Bezorgd en geannoteerd door G.J. Knaap. Franeker: Van Wijnen, 1988, liv + 447 p. - Franois Raillon, William H. Frederick, Visions and heat; The making of the Indonesian revolution, Athens: Ohio University Press, 1989. 339 pp. - Reimar Schefold, Barbara Lüem, Wir sind wie der Berg, lächelnd aber stark: Eine studie zur ethnischen indentität der Tenggeresen in Ostjava, Basel: Ethnologisches Seminar der Universität und Museum für Völkerkunde. Distributed by Wepf & Co. AG Verlag, 1988, 243 pp.; ill. - J.W. Schoorl, J. van Baal, Ontglipt verleden; Verhaal van mijn jaren in een wereld die voorbijging, deel I, Tot 1947: Indisch bestuursambtenaar in vrede en oorlog; deel II, Leven in verandering: 1947-1958, Franeker: Wever. 1986, 510 pp., resp. 1989, 616 pp. - I. Serpenti, Miriam Kahn, Always hungry - Never greedy; Food and the expression of gender in a Melanesian society

  8. Dergilerden Özetler

    Directory of Open Access Journals (Sweden)

    Mehmet Akif İnanıcı

    1997-12-01

    Positive Identification of Human Remains - A Case Report Valenzuela A. Am J Forensic Med Pathol. 1997; 18(2:215-6. Kimliği bilinmeyen bir kadavrada lomber omurları gösteren antemortem ve postmortem batın grafileri karşılaştırılmıştır. Üçüncü, dördüncü ve beşinci lomber omurda yaygın osteoporoz, spinal ve transveıs çıkıntıların belirginliği, sağ lomber skolyozdaki eşit açılanma gibi özelliklerin birbirine uyduğu gösterilmiştir. Kimliklendirmede kullanılan yöntemlerin eleştirisi sunulmuştur. TRAVMATİK KAROTİS ARTER DİSEKSİYONU Traumatic Carotid Artery Dissection Opes kin K. Am J Forensic Med Pathol 1997; 18(3:251-7. Travmatik karotis arter disseksiyonu adli tıbbi pratikte ölüm nedenleri arasında seyrek olarak görülmektedir. Tipik birçok özellikler gösteren üç travmatik karotis arter diseksiyon olgusu sunulmaktadır. Genellikle kafa ve boyna yönelik travma hikayesi bulunmaktadır ve en yaygın neden motorlu araç kazalarıdır. Karotis arter, ana karotis kolundan başlayarak kaver- nöz sinüse kadar herhangi bir bölümden yaralanabil- mekte ve bu ilgili beyin hemisferinin infaıktı ile sonuçlanmaktadır. Klinik semptomlar, şuur kaybı, hemi- parezi, afazi, Horner sendromudur. Bunlar tipik olarak saatler ya da günler sonra ortaya çıkabilmektedir. Karotis arter yaralanması bir dış yaralanma ile birlikte olabilir ve ilk anda saptanmayabilir ya da boyun veya kafa travması ile ilişkisi kurulmayabilir. En yaygın mekanizma, boyun travması ve boyun hiperekstansiyonu olarak düşünülmektedir. Sunulan olgularda erken tanının önemi vurgulanmaktadır. Eğer cerrahi müdahale olanağı olsa ölüm ile sonuçlanmayabileceği belirtilmektedir. MOTORLU TAŞIT KULLANIRKEN ATEŞLİ SİLAH İLE İNTİHAR - EK İKİ OLGU Suicide by Gunshot While Driving a Motor Vehicle - Two Additional Cases Murphy GK. Am J Forensic Med Pathol. 1997; 18(3:295-8. Motorlu taşıtla intihar genel olarak beklenenden daha sık olarak olu