WorldWideScience

Sample records for large statewide study

  1. Florida statewide radiation study

    International Nuclear Information System (INIS)

    Nagda, N.L.; Koontz, M.D.; Fortmann, R.C.; Schoenborn, W.A.; Mehegan, L.L.

    1987-01-01

    Florida phosphate deposits contain higher levels of uranium than most other soils and rocks, thus exposing the population to higher-than-desirable levels of radon and its short-lived daughters. The Florida Legislature ordered a survey of significant land areas where an environmental radiation standard should be applied. Among other things, the study assessed indoor radon in 6,000 homes, soil radon at 3,000 residences, and all data existing prior to the study. The report explains the purpose of the study, how it was designed and conducted, and its results. It concludes with a discussion of radon/radon decay product equilibrium factor, correlation between indoor and soil radon, and preliminary attempts to develop a safe threshold for soil radon below which few elevated indoor levels would be anticipated

  2. Nebraska Statewide Wind Integration Study: April 2008 - January 2010

    Energy Technology Data Exchange (ETDEWEB)

    EnerNex Corporation, Knoxville, Tennessee; Ventyx, Atlanta, Georgia; Nebraska Power Association, Lincoln, Nebraska

    2010-03-01

    Wind generation resources in Nebraska will play an increasingly important role in the environmental and energy security solutions for the state and the nation. In this context, the Nebraska Power Association conducted a state-wide wind integration study.

  3. Statewide mesoscopic simulation for Wyoming.

    Science.gov (United States)

    2013-10-01

    This study developed a mesoscopic simulator which is capable of representing both city-level and statewide roadway : networks. The key feature of such models are the integration of (i) a traffic flow model which is efficient enough to : scale to larg...

  4. Final Report on the Study of the Impact of the Statewide Systemic Initiatives. Lessons Learned about Designing, Implementing, and Evaluating Statewide Systemic Reform. WCER Working Paper No. 2003-12

    Science.gov (United States)

    Heck, Daniel J.; Weiss, Iris R.; Boyd, Sally E.; Howard, Michael N.; Supovitz, Jonathan A.

    2003-01-01

    This document represents the first of two volumes presented in "Study of the Impact of the Statewide Systemic Initiatives Program" (Norman L. Webb and Iris R. Weiss). In an effort to evaluate the impact of the Statewide Systemic Initiatives (SSIs) on student achievement and the lessons that could be learned from the National Science…

  5. Salary and Ranking and Teacher Turnover: A Statewide Study

    Science.gov (United States)

    Garcia, Cynthia Martinez; Slate, John R.; Delgado, Carmen Tejeda

    2009-01-01

    This study examined three years of data obtained from the Academic Excellence Indicator System of the State of Texas regarding teacher turnover rate and teacher salary. Across all public school districts, teacher salary was consistently negatively related to teacher turnover; that is, where salary was lower, turnover rate was higher When data were…

  6. A case study: planning a statewide information resource for health professionals: an evidence-based approach

    Science.gov (United States)

    Chew, Katherine; Watson, Linda; Parker, Mary

    2009-01-01

    Question: What is the best approach for implementing a statewide electronic health library (eHL) to serve all health professionals in Minnesota? Setting: The research took place at the University of Minnesota Health Sciences Libraries. Methods: In January 2008, the authors began planning a statewide eHL for health professionals following the five-step process for evidence-based librarianship: formulating the question, finding the best evidence, appraising the evidence, assessing costs and benefits, and evaluating the effectiveness of resulting actions. Main Results: The authors identified best practices for developing a statewide eHL for health professionals relating to audience or population served, information resources, technology and access, funding model, and implementation and sustainability. They were compared to the mission of the eHL project to drive strategic directions by developing recommendations. Conclusion: EBL can guide the planning process for a statewide eHL, but findings must be tailored to the local environment to address information needs and ensure long-term sustainability. PMID:19851487

  7. Peer Crowd Identification and Adolescent Health Behaviors: Results From a Statewide Representative Study.

    Science.gov (United States)

    Jordan, Jeffrey W; Stalgaitis, Carolyn A; Charles, John; Madden, Patrick A; Radhakrishnan, Anjana G; Saggese, Daniel

    2018-02-01

    Peer crowds are macro-level subcultures that share similarities across geographic areas. Over the past decade, dozens of studies have explored the association between adolescent peer crowds and risk behaviors, and how they can inform public health efforts. However, despite the interest, researchers have not yet reported on crowd size and risk levels from a representative sample, making it difficult for practitioners to apply peer crowd science to interventions. The current study reports findings from the first statewide representative sample of adolescent peer crowd identification and health behaviors. Weighted data were analyzed from the 2015 Virginia Youth Survey of Health Behaviors ( n = 4,367). Peer crowds were measured via the I-Base Survey™, a photo-based peer crowd survey instrument. Frequencies and confidence intervals of select behaviors including tobacco use, substance use, nutrition, physical activity, and violence were examined to identify high- and low-risk crowds. Logistic regression was used to calculate adjusted odds ratios for each crowd and behavior. Risky behaviors clustered in two peer crowds. Hip Hop crowd identification was associated with substance use, violence, and some depression and suicidal behaviors. Alternative crowd identification was associated with increased risk for some substance use behaviors, depression and suicide, bullying, physical inactivity, and obesity. Mainstream and, to a lesser extent, Popular, identities were associated with decreased risk for most behaviors. Findings from the first representative study of peer crowds and adolescent behavior identify two high-risk groups, providing critical insights for practitioners seeking to maximize public health interventions by targeting high-risk crowds.

  8. Outcome of the 'Drip-and-Ship' Paradigm among Patients with Acute Ischemic Stroke: Results of a Statewide Study.

    Science.gov (United States)

    Qureshi, Adnan I; Chaudhry, Saqib A; Rodriguez, Gustavo J; Suri, M Fareed K; Lakshminarayan, Kamakshi; Ezzeddine, Mustapha A

    2012-01-01

    65,669 for primary ED arrival and USD 47,850 for drip-and-ship-treated patients (p paradigm compared with those treated by primary ED arrival mode (p = 0.015). CONCLUSIONS: The results of the drip-and-ship paradigm compare favorably with IV rt-PA treatment through primary ED arrival in this statewide study. Our results support the recommendations of various professional organizations that the drip-and-ship method of IV rt-PA administration for stroke may be an effective option for increasing the utilization of IV rt-PA on a large scale.

  9. Family-friendliness in Medical Studies in Baden-Württemberg. Results of a state-wide study.

    Science.gov (United States)

    Niehues, Johanna; Prospero, Katrin; Fegert, Jörg M; Liebhardt, Hubert

    2012-01-01

    This paper describes the results of the study on "Family-friendliness of the Medical Studies in Baden-Württemberg" carried out in 2009-2011 by the working group "Family, Time policy and E-Learning" of the University Hospital of Ulm, supported by the Ministry of Science, Research and the Arts of Baden-Württemberg. This state-wide survey of the studying conditions and personal circumstances of medical students with children at the five medical schools in Baden-Württemberg aims to describe existing and necessary factors of family-friendliness. A total of 238 students with children participated in the quantitative online survey conducted during the summer semester 2010 which was based on topics from previous qualitative interviews with student parents.The data shows that even though founding a family while at university is usually planned, student parents are faced with significant compatibility issues, demonstrating the need for additional measures to individualise course organisation and to make the curriculum more flexible. At the same time, the need to significantly increase information and advisory services alongside the establishment of additional support services for student parents is discernable. The study contributes to the debate on the family-friendliness of universities and university hospitals and adds practice-oriented approaches to solutions.

  10. Statewide Suicide Prevention Council

    Science.gov (United States)

    State Employees Statewide Suicide Prevention Council DHSS State of Alaska Home Divisions and Agencies National Suicide Prevention Lifeline Alaska Community Mental Health Centers National Survivors of Suicide Meetings Presentations 2010 Alaska Statewide Suicide Prevention Summit: Mending the Net Connect with us on

  11. Open access tools for quality-assured and efficient data entry in a large, state-wide tobacco survey in India.

    Science.gov (United States)

    Shewade, Hemant Deepak; Vidhubala, E; Subramani, Divyaraj Prabhakar; Lal, Pranay; Bhatt, Neelam; Sundaramoorthi, C; Singh, Rana J; Kumar, Ajay M V

    2017-01-01

    A large state-wide tobacco survey was conducted using modified version of pretested, globally validated Global Adult Tobacco Survey (GATS) questionnaire in 2015-22016 in Tamil Nadu, India. Due to resource constrains, data collection was carrid out using paper-based questionnaires (unlike the GATS-India, 2009-2010, which used hand-held computer devices) while data entry was done using open access tools. The objective of this paper is to describe the process of data entry and assess its quality assurance and efficiency. In EpiData language, a variable is referred to as 'field' and a questionnaire (set of fields) as 'record'. EpiData software was used for double data entry with adequate checks followed by validation. Teamviewer was used for remote training and trouble shooting. The EpiData databases (one each for each district and each zone in Chennai city) were housed in shared Dropbox folders, which enabled secure sharing of files and automatic back-up. Each database for a district/zone had separate file for data entry of household level and individual level questionnaire. Of 32,945 households, there were 111,363 individuals aged ≥15 years. The average proportion of records with data entry errors for a district/zone in household level and individual level file was 4% and 24%, respectively. These are the errors that would have gone unnoticed if single entry was used. The median (inter-quartile range) time taken for double data entry for a single household level and individual level questionnaire was 30 (24, 40) s and 86 (64, 126) s, respectively. Efficient and quality-assured near-real-time data entry in a large sub-national tobacco survey was performed using innovative, resource-efficient use of open access tools.

  12. Methicillin-resistant Staphylococcus aureus in Saarland, Germany: a statewide admission prevalence screening study.

    Directory of Open Access Journals (Sweden)

    Mathias Herrmann

    Full Text Available BACKGROUND: The screening of hospital admission patients for methicillin resistant Staphylococcus aureus (MRSA is of undisputed value in controlling and reducing the overall MRSA burden; yet, a concerted parallel universal screening intervention throughout all hospitals of an entire German Federal State has not yet been performed. METHODOLOGY/PRINCIPAL FINDINGS: During a four-week period, all 24 acute care hospitals of the State of Saarland participated in admission prevalence screening. Overall, 436/20,027 screened patients revealed MRSA carrier status (prevalence, 2.2/100 patients with geriatrics and intensive care departments associated with highest prevalence (7.6/100 and 6.3/100, respectively. Risk factor analysis among 17,975 admission patients yielded MRSA history (OR, 4.3; CI₉₅ 2.7-6.8, a skin condition (OR, 3.2; CI₉₅ 2.1-5.0, and/or an indwelling catheter (OR, 2.2; CI₉₅ 1.4-3.5 among the leading risks. Hierarchical risk factor ascertainment of the six risk factors associated with highest odd's ratios would require 31% of patients to be laboratory screened to allow for detection of 67% of all MRSA positive admission patients in the State. CONCLUSIONS/SIGNIFICANCE: State-wide admission prevalence screening in conjunction with risk factor ascertainment yields important information on the distribution of the MRSA burden for hospitals, and allows for data-based decisions on local or institutional MRSA screening policies considering risk factor prevalence and expected MRSA identification rates.

  13. Characteristics of national and statewide health care-associated infection surveillance programs: A qualitative study.

    Science.gov (United States)

    Russo, Philip L; Havers, Sally M; Cheng, Allen C; Richards, Michael; Graves, Nicholas; Hall, Lisa

    2016-12-01

    There are many well-established national health care-associated infection surveillance programs (HAISPs). Although validation studies have described data quality, there is little research describing important characteristics of large HAISPs. The aim of this study was to broaden our understanding and identify key characteristics of large HAISPs. Semi-structured interviews were conducted with purposively selected leaders from national and state-based HAISPs. Interview data were analyzed following an interpretive description process. Seven semi-structured interviews were conducted over a 6-month period during 2014-2015. Analysis of the data generated 5 distinct characteristics of large HAISPs: (1) triggers: surveillance was initiated by government or a cooperative of like-minded people, (2) purpose: a clear purpose is needed and determines other surveillance mechanisms, (3) data measures: consistency is more important than accuracy, (4) processes: a balance exists between the volume of data collected and resources, and (5) implementation and maintenance: a central coordinating body is crucial for uniformity and support. National HAISPs are complex and affect a broad range of stakeholders. Although the overall goal of health care-associated infection surveillance is to reduce the incidence of health care-associated infection, there are many crucial factors to be considered in attaining this goal. The findings from this study will assist the development of new HAISPs and could be used as an adjunct to evaluate existing programs. Copyright © 2016 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.

  14. WisDOT statewide customer satisfaction survey.

    Science.gov (United States)

    2013-02-01

    The purpose of this study was to develop and initiate a new customer satisfaction tool that would establish a set of baseline : departmental performance measures and be sustainable for future use. ETC Institute completed a statewide customer : survey...

  15. California drug courts: outcomes, costs and promising practices: an overview of Phase II in a statewide study.

    Science.gov (United States)

    Carey, Shannon M; Finigan, Michael; Crumpton, Dave; Waller, Mark

    2006-11-01

    The rapid expansion of drug courts in California and the state's uncertain fiscal climate highlighted the need for definitive cost information on drug court programs. This study focused on creating a research design that can be utilized for statewide and national cost-assessment of drug courts by conducting in-depth case studies of the costs and benefits in nine adult drug courts in California. A Transactional Institutional Costs Analysis (TICA) approach was used, allowing researchers to calculate costs based on every individual's transactions within the drug court or the traditional criminal justice system. This methodology also allows the calculation of costs and benefits by agency (e.g., Public Defender's office, court, District Attorney). Results in the nine sites showed that the majority of agencies save money in processing an offender though drug court. Overall, for these nine study sites, participation in drug court saved the state over 9 million dollars in criminal justice and treatment costs due to lower recidivism in drug court participants. Based on the lessons learned in Phases I and II, Phase III of this study focuses on the creation of a web-based drug court cost self-evaluation tool (DC-CSET) that drug courts can use to determine their own costs and benefits.

  16. Reaching people with energy conservation information: four statewide residential case studies

    Energy Technology Data Exchange (ETDEWEB)

    Peelle, E.; Braid, R.B.; Jones, D.W.; Reed, J.H.

    1983-09-01

    Four state residential energy conservation programs are reviewed in terms of their origins, evolutions, purposes and goals, administration, organization, and outcomes. The four programs chosen were selected from among 30 nominated by state energy offices and regional Department of Energy personnel as being illustrative in terms of organization and/or outcomes. While intended primarily for state-level program managers and staff, the profiles of programs, conclusions, and recommendations should be useful to anyone interested in developing viable, action-oriented conservation programs. The four case studies included Oregon's Master Conserver program, Oklahoma's energy education project for low-income and elderly families, Virginia's workshops for heating dealers service and contractors, and Maine's three energy education projects - the Energy Bus, Energy Conservation Month, and the Home Energy Check-up. All four programs utilized Energy Extension Service (EES) funds from the federal government, and three were directly managed through the state EES organization. The findings of the study indicate that these programs (1) had flexibility to experiment, iterate, and reorganize as a result of their initial experiences, (2) made extensive use of networking to involve local groups in program delivery, (3) employed a large variety of delivery methods, and (4) made substantial efforts to tailor literature and handouts to the target audiences.

  17. Safe routes to school (SRTS) statewide mobility assessment study : phase I report.

    Science.gov (United States)

    2010-01-01

    This report presents the results of phase one of a two phase study designed to support state-level management of the Federal Highway Administration Safe Routes to School (SRTS) program. The study aims to achieve three objectives: (1) identify and use...

  18. Statewide Study of School Public Relations Personnel: Roles, Responsibilities, Relationships, and Budget Vote Outcomes

    Science.gov (United States)

    Knight, Catherine

    2013-01-01

    This two-part quantitative study expanded our understanding of school PR personnel in public school districts, particularly those who worked during the 2009-2012 budget years. Four cultural changes have redefined the paradigm of public education and served as a springboard for this study: technology-enhanced communications information retrieval,…

  19. Supporting Statewide Implementation of the Learning School Initiative. Catalyst Schools Research Study Report

    Science.gov (United States)

    Hammer, Patricia Cahape

    2016-01-01

    This is the first in a series of reports based on a research study, Developing Effective Professional Learning Communities in Catalyst Schools, conducted between February 2015 and June 2016. "Catalyst schools" were elementary- and secondary-level schools selected to participate in a pilot project intended to explore how best to support…

  20. Louisiana's statewide beach cleanup

    Science.gov (United States)

    Lindstedt, Dianne M.; Holmes, Joseph C.

    1989-01-01

    Litter along Lousiana's beaches has become a well-recognized problem. In September 1987, Louisiana's first statewide beach cleanup attracted about 3300 volunteers who filled 16,000 bags with trash collected along 15 beaches. An estimated 800,173 items were gathered. Forty percent of the items were made of plastic and 11% were of polystyrene. Of all the litter collected, 37% was beverage-related. Litter from the oil and gas, commercial fishing, and maritime shipping industries was found, as well as that left by recreational users. Although beach cleanups temporarily rid Louisiana beaches of litter, the real value of the effort is in public participation and education. Civic groups, school children, and individuals have benefited by increasing their awareness of the problems of trash disposal.

  1. Effects of Road Salt on Connecticut's Groundwater: A Statewide Centennial Perspective.

    Science.gov (United States)

    Cassanelli, James P; Robbins, Gary A

    2013-01-01

    This study examined the extent to which development and road salting has affected Connecticut's groundwater. We gathered water quality data from different time periods between 1894 and the present and analyzed the data using maps generated with ESRI ArcGIS. Historical reports illustrate a statewide baseline trend of decreasing chloride concentration northward across the State (average, 2 ppm). Since then, statewide chloride concentrations in ground water have increased by more than an order of magnitude on average. Analysis indicates spatial correlation between chloride impacts and major roadways. Furthermore, increases in statewide chloride concentration parallel increases in road salt application. Projected trends suggest that statewide baseline concentrations will increase by an amount equal to five times background levels between the present and the year 2030. The analytical process outlined herein can be readily applied to any region to investigate salt impacts on large spatial and temporal scales. Copyright © by the American Society of Agronomy, Crop Science Society of America, and Soil Science Society of America, Inc.

  2. Data integration for statewide transportation planning : final report

    Science.gov (United States)

    2009-08-01

    The goal of this study was to investigate the data availability, accessibility, and interoperability issues arisen from the statewide : transportation planning activities undertaken at WisDOT and to identify possible approaches for addressing these i...

  3. Costs and effects of a state-wide health promotion program in primary schools in Germany - the Baden-Württemberg Study: A cluster-randomized, controlled trial.

    Directory of Open Access Journals (Sweden)

    Dorothea Kesztyüs

    Full Text Available To evaluate the cost-effectiveness of the state-wide implementation of the health promotion program "Join the Healthy Boat" in primary schools in Germany.Cluster-randomized intervention trial with wait-list control group. Anthropometric data of 1733 participating children (7.1 ± 0.6 years were taken by trained staff before and after a one year intervention period in the academic year 2010/11. Parents provided information about the health status, and the health behaviour of their children and themselves, parental anthropometrics, and socio-economic background variables. Incidence of abdominal obesity, defined as waist-to-height ratio (WHtR ≥ 0.5, was determined. Generalized linear models were applied to account for the clustering of data within schools, and to adjust for baseline-values. Losses to follow-up and missing data were analysed. From a societal perspective, the overall costs, costs per pupil, and incremental cost-effectiveness ratio (ICER to identify the costs per case of averted abdominal obesity were calculated.The final regression model for the incidence of abdominal obesity shows lower odds for the intervention group after an adjustment for grade, gender, baseline WHtR, and breakfast habits (odds ratio = 0.48, 95% CI [0.25; 0.94]. The intervention costs per child/year were €25.04. The costs per incidental case of averted abdominal obesity varied between €1515 and €1993, depending on the different dimensions of the target group.This study demonstrates the positive effects of state-wide, school-based health promotion on incidental abdominal obesity, at affordable costs and with proven cost-effectiveness. These results should support allocative decisions of policymakers. An early start to the prevention of abdominal obesity is of particular importance because of its close relationship to non-communicable diseases.German Clinical Trials Register (DRKS, Freiburg University, Germany, DRKS-ID: DRKS00000494.

  4. Alabama statewide mobility report, 2014.

    Science.gov (United States)

    2015-09-01

    This Alabama Statewide Mobility Report for 2014 is a new way to analyze interstate mobility performance over an entire year. Over half a billion speed records were acquired, stored, and analyzed for this report. These observations capture recurring c...

  5. The relationship between processes and outcomes for injured older adults: a study of a statewide trauma system.

    Science.gov (United States)

    Saillant, N N; Earl-Royal, E; Pascual, J L; Allen, S R; Kim, P K; Delgado, M K; Carr, B G; Wiebe, D; Holena, D N

    2017-02-01

    Age is a risk factor for death, adverse outcomes, and health care use following trauma. The American College of Surgeons' Trauma Quality Improvement Program (TQIP) has published "best practices" of geriatric trauma care; adoption of these guidelines is unknown. We sought to determine which evidence-based geriatric protocols, including TQIP guidelines, were correlated with decreased mortality in Pennsylvania's trauma centers. PA's level I and II trauma centers self-reported adoption of geriatric protocols. Survey data were merged with risk-adjusted mortality data for patients ≥65 from a statewide database, the Pennsylvania Trauma Systems Foundation (PTSF), to compare mortality outlier status and processes of care. Exposures of interest were center-specific processes of care; outcome of interest was PTSF mortality outlier status. 26 of 27 eligible trauma centers participated. There was wide variation in care processes. Four trauma centers were low outliers; three centers were high outliers for risk-adjusted mortality rates in adults ≥65. Results remained consistent when accounting for center volume. The only process associated with mortality outlier status was age-specific solid organ injury protocols (p = 0.04). There was no cumulative effect of multiple evidence-based processes on mortality rate (p = 0.50). We did not see a link between adoption of geriatric best-practices trauma guidelines and reduced mortality at PA trauma centers. The increased susceptibility of elderly to adverse consequences of injury, combined with the rapid growth rate of this demographic, emphasizes the importance of identifying interventions tailored to this population. III. Descriptive.

  6. Inconsistency in large pharmacogenomic studies

    DEFF Research Database (Denmark)

    Haibe-Kains, Benjamin; El-Hachem, Nehme; Birkbak, Nicolai Juul

    2013-01-01

    Two large-scale pharmacogenomic studies were published recently in this journal. Genomic data are well correlated between studies; however, the measured drug response data are highly discordant. Although the source of inconsistencies remains uncertain, it has potential implications for using...

  7. A Framework for Statewide Analysis of Site Suitability, Energy Estimation, Life Cycle Costs, Financial Feasibility and Environmental Assessment of Wind Farms: A Case Study of Indiana

    Science.gov (United States)

    Kumar, Indraneel

    In the last decade, Midwestern states including Indiana have experienced an unprecedented growth in utility scale wind energy farms. For example, by end of 2013, Indiana had 1.5 GW of wind turbines installed, which could provide electrical energy for as many as half-a-million homes. However, there is no statewide systematic framework available for the evaluation of wind farm impacts on endangered species, required necessary setbacks and proximity standards to infrastructure, and life cycle costs. This research is guided to fill that gap and it addresses the following questions. How much land is suitable for wind farm siting in Indiana given the constraints of environmental, ecological, cultural, settlement, physical infrastructure and wind resource parameters? How much wind energy can be obtained? What are the life cycle costs and economic and financial feasibility? Is wind energy production and development in a state an emission free undertaking? The framework developed in the study is applied to a case study of Indiana. A fuzzy logic based AHP (Analytic Hierarchy Process) spatial site suitability analysis for wind energy is formulated. The magnitude of wind energy that could be sited and installed comprises input for economic and financial feasibility analysis for 20-25 years life cycle of wind turbines in Indiana. Monte Carlo simulation is used to account for uncertainty and nonlinearity in various costs and price parameters. Impacts of incentives and cost variables such as production tax credits, costs of capital, and economies of scale are assessed. Further, an economic input-output (IO) based environmental assessment model is developed for wind energy, where costs from financial feasibility analysis constitute the final demand vectors. This customized model for Indiana is used to assess emissions for criteria air pollutants, hazardous air pollutants and greenhouse gases (GHG) across life cycle events of wind turbines. The findings of the case study include

  8. Successful Statewide Walking Program Websites

    Science.gov (United States)

    Teran, Bianca Maria; Hongu, Nobuko

    2012-01-01

    Statewide Extension walking programs are making an effort to increase physical activity levels in America. An investigation of all 20 of these programs revealed that 14 use websites as marketing and educational tools, which could prove useful as the popularity of Internet communities continues to grow. Website usability information and an analysis…

  9. Large Aspect Ratio Tokamak Study

    International Nuclear Information System (INIS)

    Reid, R.L.; Holmes, J.A.; Houlberg, W.A.; Peng, Y.K.M.; Strickler, D.J.; Brown, T.G.; Wiseman, G.W.

    1980-06-01

    The Large Aspect Ratio Tokamak Study (LARTS) at Oak Ridge National Laboratory (ORNL) investigated the potential for producing a viable longburn tokamak reactor by enhancing the volt-second capability of the ohmic heating transformer through the use of high aspect ratio designs. The plasma physics, engineering, and economic implications of high aspect ratio tokamaks were assessed in the context of extended burn operation. Using a one-dimensional transport code plasma startup and burn parameters were addressed. The pulsed electrical power requirements for the poloidal field system, which have a major impact on reactor economics, were minimized by optimizing the startup and shutdown portions of the tokamak cycle. A representative large aspect ratio tokamak with an aspect ratio of 8 was found to achieve a burn time of 3.5 h at capital cost only approx. 25% greater than that of a moderate aspect ratio design tokamak

  10. Health-related quality of life of mothers of very low birth weight children at the age of five: results from the Newborn Lung Project Statewide Cohort Study.

    Science.gov (United States)

    Witt, Whitney P; Litzelman, Kristin; Spear, Hilary A; Wisk, Lauren E; Levin, Nataliya; McManus, Beth M; Palta, Mari

    2012-11-01

    This study aimed to determine the health-related quality of life (HRQoL) in mothers of 5-year-old very low birth weight (VLBW) and normal birth weight (NBW) children, with a focus on the role of stress. This cohort study is ancillary to the Newborn Lung Project. A telephone interview collected information on symptoms of stress and HRQoL from 297 mothers of VLBW children and 290 mothers of NBW children who were enrolled in the Newborn Lung Project Statewide Cohort Study. Staged multiple regression analyses were used to evaluate the relationship between caregiver status and maternal HRQoL and the role stress played in this relationship. Additional multiple regression analyses were also used to evaluate the correlates of poor maternal HRQoL among VLBW mothers. Mothers of VLBW children experienced worse physical and mental HRQoL than mothers of NBW children. Adjusted analyses showed that physical HRQoL was significantly different between these mothers (β: -1.87, P = 0.001); this relationship was attenuated by maternal stress. Among the mothers of VLBW children, stress significantly contributed to adverse HRQoL outcomes when children were aged five. Child behavior problems at the age of two were also associated with worse subsequent maternal mental HRQoL (β: -0.18, P = 0.004), while each week of neonatal intensive care unit stay was associated with worse physical HRQoL (β: -0.26, P = 0.02). Caring for a VLBW child is negatively associated with the HRQoL of mothers; this relationship might be, in part, explained by maternal stress. Addressing maternal stress may be an important way to improve long-term HRQoL.

  11. Large scale nuclear structure studies

    International Nuclear Information System (INIS)

    Faessler, A.

    1985-01-01

    Results of large scale nuclear structure studies are reported. The starting point is the Hartree-Fock-Bogoliubov solution with angular momentum and proton and neutron number projection after variation. This model for number and spin projected two-quasiparticle excitations with realistic forces yields in sd-shell nuclei similar good results as the 'exact' shell-model calculations. Here the authors present results for a pf-shell nucleus 46 Ti and results for the A=130 mass region where they studied 58 different nuclei with the same single-particle energies and the same effective force derived from a meson exchange potential. They carried out a Hartree-Fock-Bogoliubov variation after mean field projection in realistic model spaces. In this way, they determine for each yrast state the optimal mean Hartree-Fock-Bogoliubov field. They apply this method to 130 Ce and 128 Ba using the same effective nucleon-nucleon interaction. (Auth.)

  12. Mothers of Very Low Birth Weight Children at School Age: Quality of Life Outcomes from the Newborn Lung Project Statewide Cohort Study

    Science.gov (United States)

    Witt, Whitney P.; Litzelman, Kristin; Spear, Hilary A.; Wisk, Lauren E.; Levin, Nataliya; McManus, Beth M.; Palta, Mari

    2012-01-01

    Purpose This study aimed to: (1) determine the health-related quality of life (HRQoL) in mothers of five year old very low birth weight (VLBW) and normal birth weight (NBW) children; (2) determine what extent stress mediates the relationship between case status and maternal HRQoL; and (3) examine the pre-pregnancy, pregnancy, birth, and child health-related factors in predicting maternal HRQoL among mothers of five year old VLBW children. Methods A telephone interview was administered to 297 mothers of VLBW children and 290 mothers of NBW children who were enrolled in the Newborn Lung Project Statewide Cohort Study. Results Mothers of VLBW children experienced worse physical and mental HRQoL than mothers of NBW children (52.8 versus 55.3 points, p<0.0001, and 48.9 versus 50.5 points, p=0.02, respectively). Adjusted analyses showed that maternal mental HRQoL was similar between cases and controls while physical HRQoL when children were age five was significantly different between cases and controls (Beta:−2.02, p=0.0006); this relationship was mediated by maternal stress. Among mothers of VLBW children, stress significantly contributed to adverse HRQoL outcomes when children were age five. Child behavior problems at age two were also associated with worse subsequent maternal mental HRQoL (Beta: −1.8 per SD, p=0.004), while each week of neonatal intensive care unit stay was associated with worse physical HRQoL (Beta: −0.26, p=0.02). Conclusions While caring for a VLBW child negatively impacts the HRQoL of mothers, this relationship was partially explained by maternal stress. Addressing maternal stress may be an important way to improve long-term HRQoL. PMID:22161725

  13. Large aspect ratio tokamak study

    International Nuclear Information System (INIS)

    Reid, R.L.; Holmes, J.A.; Houlberg, W.A.; Peng, Y.K.M.; Strickler, D.J.; Brown, T.G.; Sardella, C.; Wiseman, G.W.

    1979-01-01

    The Large Aspect Ratio Tokamak Study (LARTS) investigated the potential for producing a viable long burn tokamak reactor through enhanced volt-second capability of the ohmic heating transformer by employing high aspect ratio designs. The plasma physics, engineering, and economic implications of high aspect ratio tokamaks were accessed in the context of extended burn operation. Plasma startup and burn parameters were addressed using a one-dimensional transport code. The pulsed electrical power requirements for the poloidal field system, which have a major impact on reactor economics, were minimized by optimizing the field in the ohmic heating coil and the wave shape of the ohmic heating discharge. A high aspect ratio reference reactor was chosen and configured

  14. Joint studies on large CANDU

    International Nuclear Information System (INIS)

    Lee, Ikhwan; Yu, S. K. W.

    1994-01-01

    from economic, safety and strategic viewpoints. A large number of research and development programs are now in place at AECL and KAERI that will permit substantial improvements to be realized in the next generation of CANDU okabts, Furthermore, opportunities exist for engineered improvements based on the research and development in advancing the generic CANDU Technology. Final Large CANDU joint study report with technical deliverables will be issued 1994 October. Phase 2 R and D program of the joint studies will be determined this year and implemented in next year. CANDU neutron economy permits versatility in choices of fuel cycles. This allows a utility to choose fuel cycle options for lower fuelling cost, better security of supply, and ultimately for much lower spent-fuel volume, than with PWR's alone. To meet Korea's strategic requirements, CANDU should be an integral part of the electricity supply mix.

  15. High School Principals and School Reform: Lessons Learned from a Statewide Study of Project Re:Learning.

    Science.gov (United States)

    Anderson, Lorin W.; Shirley, J. Robert

    1995-01-01

    Summarizes a study examining the high school principal's role in providing the leadership needed to explore and implement Project Re:Learning. The 4-phase study initially included 15 schools and involved questionnaires, interviews, and shadowing. Identifies six types of administrators: the absent administrator, the pawn, the pragmatic principal,…

  16. Recruiting families at risk for hereditary breast and ovarian cancer from a statewide cancer registry: a methodological study.

    Science.gov (United States)

    Katapodi, Maria C; Duquette, Deb; Yang, James J; Mendelsohn-Victor, Kari; Anderson, Beth; Nikolaidis, Christos; Mancewicz, Emily; Northouse, Laurel L; Duffy, Sonia; Ronis, David; Milliron, Kara J; Probst-Herbst, Nicole; Merajver, Sofia D; Janz, Nancy K; Copeland, Glenn; Roberts, Scott

    2017-03-01

    Cancer genetic services (counseling/testing) are recommended for women diagnosed with breast cancer younger than 45 years old (young breast cancer survivors-YBCS) and at-risk relatives. We present recruitment of YBCS, identification and recruitment of at-risk relatives, and YBCS willingness to contact their cancer-free, female relatives. A random sample of 3,000 YBCS, stratified by race (Black vs. White/Other), was identified through a population-based cancer registry and recruited in a randomized trial designed to increase use of cancer genetic services. Baseline demographic, clinical, and family characteristics, and variables associated with the Theory of Planned Behavior (TPB) were assessed as predictors of YBCS' willingness to contact at-risk relatives. The 883 YBCS (33.2% response rate; 40% Black) who returned a survey had 1,875 at-risk relatives and were willing to contact 1,360 (72.5%). From 853 invited at-risk relatives (up to two relatives per YBCS), 442 responded (51.6% response rate). YBCS with larger families, with a previous diagnosis of depression, and motivated to comply with recommendations from family members were likely to contact a greater number of relatives. Black YBCS were more likely to contact younger relatives and those living further than 50 miles compared to White/Other YBCS. It is feasible to recruit diverse families at risk for hereditary cancer from a population-based cancer registry. This recruitment approach can be used as a paradigm for harmonizing processes and increasing internal and external validity of large-scale public health genomic initiatives in the era of precision medicine.

  17. Differences in mathematics and science performance by economic status, gender, and ethnicity/race: A multiyear Texas statewide study

    Science.gov (United States)

    Anderson, Pamela Bennett

    Purpose. The purpose of the first study was to ascertain the extent to which differences were present in the STAAR Mathematics and Science test scores by Grade 5 and Grade 8 student economic status. The purpose of the second study was to examine differences in Grade 5 STAAR Mathematics and Science test performance by gender and by ethnicity/race (i.e., Asian, Black, Hispanic, and White). Finally, with respect to the third study in this journal-ready dissertation, the purpose was to investigate the STAAR Mathematics and Science test scores of Grade 8 students by gender and by ethnicity/race (i.e., Asian, Black, Hispanic, and White). Method. For this journal-ready dissertation, a non-experimental, causal-comparative research design (Creswell, 2009) was used in all three studies. Grade 5 and Grade 8 STAAR Mathematics and Science test data were analyzed for the 2011-2012 through the 2014-2015 school years. The dependent variables were the STAAR Mathematics and Science test scores for Grade 5 and Grade 8. The independent variables analyzed in these studies were student economic status, gender, and ethnicity/race. Findings. Regarding the first study, statistically significant differences were present in Grade 5 and Grade 8 STAAR Mathematics and Science test scores by student economic status for each year. Moderate effect sizes (Cohen's d) were present for each year of the study for the Grade 5 STAAR Mathematics and Science exams, Grade 8 Science exams, and the 2014-2015 Grade 8 STAAR Mathematics exam. However, a small effect size was present for the 2011-2012 through 2013-2014 Grade 8 STAAR Mathematics exam. Regarding the second and third study, statistically significant differences were revealed for Grade 5 and Grade 8 STAAR Mathematics and Science test scores based on gender, with trivial effect sizes. Furthermore, statistically significant differences were present in these test scores by ethnicity/race, with moderate effects for each year of the study. With regard to

  18. Why Work for Extension? An Examination of Job Satisfaction and Motivation in a Statewide Employee Retention Study

    Science.gov (United States)

    Harder, Amy; Gouldthorpe, Jessica; Goodwin, Jeff

    2014-01-01

    Understanding motivation and job satisfaction is important for increasing rates of employee retention within Extension. The purpose of the study reported here was to explore factors positively affecting the motivation of Extension professionals in their careers. An online survey of Extension professionals in Colorado was conducted. Factors such as…

  19. The Soft Underbelly of System Change: The Role of Leadership and Organizational Climate in Turnover during Statewide Behavioral Health Reform

    OpenAIRE

    Aarons, Gregory A.; Sommerfeld, David H.; Willging, Cathleen E.

    2011-01-01

    This study examined leadership, organizational climate, staff turnover intentions, and voluntary turnover during a large-scale statewide behavioral health system reform. The initial data collection occurred nine months after initiation of the reform with a follow-up round of data collected 18 months later. A self-administered structured assessment was completed by 190 participants (administrators, support staff, providers) employed by 14 agencies. Key variables included leadership, organizati...

  20. Permission to park: A statewide study of high school parking permits to determine compliance with graduated driver licensing law.

    Science.gov (United States)

    Apanovitch, Audrey; Champany, Victoria; Wilson, Meghan; Emam, Hadeer; Ruiz, Kelly; Borrup, Kevin; Lapidus, Garry

    2015-09-01

    Motor vehicle crashes are the leading cause of fatality among teens in the United States. Beginning in the 1990s, many states enacted graduated driver licensing (GDL) systems to delay full licensure while allowing beginners to obtain experience under lower-risk conditions. Many high schools require parent and guardians of newly licensed teen drivers to complete a student parking pass application (PPA) for their son/daughter to drive, park, and transport themselves to and from school activities. The objective of this study was to describe the content of these PPAs for compliance with Connecticut's GDL law. PPAs were requested via e-mail, fax, or telephone from all Connecticut's high schools (n = 233). PPA variables included school demographics, parking rules, prohibitions and sanctions for violations, as well as reference to GDL law. Seventy-four schools were excluded because students were not allowed to park and schools did not require PPAs or declined to send us a copy of their PPAs. Of the remaining 159 schools, 122 (76.7%) sent us their PPAs. Responding schools were more likely to be suburban or rural. Most PPAs included a section on prohibitions and sanctions for driving misbehavior. Forty-three percent prohibited students from going to car during school hours, and 34% prohibited driving off campus/parking lot. Seventy percent warned of consequences for dangerous driving in parking lot, and 88% included the possibility of revocation for infractions. Only 14% had any reference to Connecticut's GDL law on their PPAs. A small percentage of Connecticut high schools include information about GDL laws on their PPAs. All states should examine their PPA content and adopt a uniform high school PPA that includes key provisions of their state's GDL laws in an effort to promote teen driving safety. Therapeutic study, level V.

  1. Alcohol policy enforcement and changes in student drinking rates in a statewide public college system: a follow-up study

    Directory of Open Access Journals (Sweden)

    Harris Sion K

    2010-08-01

    Full Text Available Abstract Background Heavy alcohol use among U.S. college students is a major contributor to young adult morbidity and mortality. The aim of this study was to examine whether college alcohol policy enforcement levels predict changes in student drinking and related behaviors in a state system of public colleges and universities, following a system-wide change to a stricter policy. Methods Students and administrators at 11 Massachusetts public colleges/universities completed surveys in 1999 (N of students = 1252, one year after the policy change, and again in 2001 (N = 1074. We calculated policy enforcement scores for each school based on the reports of deans of students, campus security chiefs, and students, and examined the correlations between perceived enforcement levels and the change in student drinking rates over the subsequent two year period, after weighting the 2001 data to adjust for demographic changes in the student body. Results Overall rates of any past-30-days drinking, heavy episodic drinking, and usual heavy drinking among past-30-days drinkers were all lower in 2001 compared to 1999. School-level analyses (N = 11 found deans' baseline reports of stricter enforcement were strongly correlated with subsequent declines in heavy episodic drinking (Pearson's r = -0.73, p = 0.011. Moreover, consistently high enforcement levels across time, as reported by deans, were associated with greater declines in heavy episodic drinking. Such relationships were not found for students' and security chiefs' reports of enforcement. Marijuana use did not rise during this period of decline in heavy drinking. Conclusions Study findings suggest that stronger enforcement of a stricter alcohol policy may be associated with reductions in student heavy drinking rates over time. An aggressive enforcement stance by deans may be an important element of an effective college alcohol policy.

  2. Seroprevalence of HCV and HIV infection among clients of the nation's longest-standing statewide syringe exchange program: A cross-sectional study of Community Health Outreach Work to Prevent AIDS (CHOW).

    Science.gov (United States)

    Salek, Thomas P; Katz, Alan R; Lenze, Stacy M; Lusk, Heather M; Li, Dongmei; Des Jarlais, Don C

    2017-10-01

    The Community Health Outreach Work to Prevent AIDS (CHOW) Project is the first and longest-standing statewide integrated and funded needle and syringe exchange program (SEP) in the US. Initiated on O'ahu in 1990, CHOW expanded statewide in 1993. The purpose of this study is to estimate the prevalences of hepatitis C virus (HCV) and human immunodeficiency virus (HIV) infection, and to characterize risk behaviors associated with infection among clients of a long-standing SEP through the analysis of the 2012 CHOW evaluation data. A cross-sectional sample of 130 CHOW Project clients was selected from January 1, 2012 through December 31, 2012. Questionnaires captured self-reported exposure information. HIV and HCV antibodies were detected via rapid, point-of-care FDA-approved tests. Log-binomial regressions were used to estimate prevalence proportion ratios (PPRs). A piecewise linear log-binomial regression model containing 1 spline knot was used to fit the age-HCV relationship. The estimated seroprevalence of HCV was 67.7% (95% confidence interval [CI]=59.5-75.8%). HIV seroprevalence was 2.3% (95% CI=0-4.9%). Anti-HCV prevalence demonstrated age-specific patterns, ranging from 31.6% through 90.9% in people who inject drugs (PWID) HIV prevalence compared with HCV prevalence reflects differences in transmissibility of these 2 blood-borne pathogens and suggests much greater efficacy of SEP for HIV prevention. Copyright © 2017 Elsevier B.V. All rights reserved.

  3. Intelligent Transportation Systems statewide architecture : final report.

    Science.gov (United States)

    2003-06-01

    This report describes the development of Kentuckys Statewide Intelligent Transportation Systems (ITS) Architecture. The process began with the development of an ITS Strategic Plan in 1997-2000. A Business Plan, developed in 2000-2001, translated t...

  4. A California statewide three-dimensional seismic velocity model from both absolute and differential times

    Science.gov (United States)

    Lin, G.; Thurber, C.H.; Zhang, H.; Hauksson, E.; Shearer, P.M.; Waldhauser, F.; Brocher, T.M.; Hardebeck, J.

    2010-01-01

    We obtain a seismic velocity model of the California crust and uppermost mantle using a regional-scale double-difference tomography algorithm. We begin by using absolute arrival-time picks to solve for a coarse three-dimensional (3D) P velocity (VP) model with a uniform 30 km horizontal node spacing, which we then use as the starting model for a finer-scale inversion using double-difference tomography applied to absolute and differential pick times. For computational reasons, we split the state into 5 subregions with a grid spacing of 10 to 20 km and assemble our final statewide VP model by stitching together these local models. We also solve for a statewide S-wave model using S picks from both the Southern California Seismic Network and USArray, assuming a starting model based on the VP results and a VP=VS ratio of 1.732. Our new model has improved areal coverage compared with previous models, extending 570 km in the SW-NE directionand 1320 km in the NW-SE direction. It also extends to greater depth due to the inclusion of substantial data at large epicentral distances. Our VP model generally agrees with previous separate regional models for northern and southern California, but we also observe some new features, such as high-velocity anomalies at shallow depths in the Klamath Mountains and Mount Shasta area, somewhat slow velocities in the northern Coast Ranges, and slow anomalies beneath the Sierra Nevada at midcrustal and greater depths. This model can be applied to a variety of regional-scale studies in California, such as developing a unified statewide earthquake location catalog and performing regional waveform modeling.

  5. Real-time web-based assessment of total population risk of future emergency department utilization: statewide prospective active case finding study.

    Science.gov (United States)

    Hu, Zhongkai; Jin, Bo; Shin, Andrew Y; Zhu, Chunqing; Zhao, Yifan; Hao, Shiying; Zheng, Le; Fu, Changlin; Wen, Qiaojun; Ji, Jun; Li, Zhen; Wang, Yong; Zheng, Xiaolin; Dai, Dorothy; Culver, Devore S; Alfreds, Shaun T; Rogow, Todd; Stearns, Frank; Sylvester, Karl G; Widen, Eric; Ling, Xuefeng B

    2015-01-13

    An easily accessible real-time Web-based utility to assess patient risks of future emergency department (ED) visits can help the health care provider guide the allocation of resources to better manage higher-risk patient populations and thereby reduce unnecessary use of EDs. Our main objective was to develop a Health Information Exchange-based, next 6-month ED risk surveillance system in the state of Maine. Data on electronic medical record (EMR) encounters integrated by HealthInfoNet (HIN), Maine's Health Information Exchange, were used to develop the Web-based surveillance system for a population ED future 6-month risk prediction. To model, a retrospective cohort of 829,641 patients with comprehensive clinical histories from January 1 to December 31, 2012 was used for training and then tested with a prospective cohort of 875,979 patients from July 1, 2012, to June 30, 2013. The multivariate statistical analysis identified 101 variables predictive of future defined 6-month risk of ED visit: 4 age groups, history of 8 different encounter types, history of 17 primary and 8 secondary diagnoses, 8 specific chronic diseases, 28 laboratory test results, history of 3 radiographic tests, and history of 25 outpatient prescription medications. The c-statistics for the retrospective and prospective cohorts were 0.739 and 0.732 respectively. Integration of our method into the HIN secure statewide data system in real time prospectively validated its performance. Cluster analysis in both the retrospective and prospective analyses revealed discrete subpopulations of high-risk patients, grouped around multiple "anchoring" demographics and chronic conditions. With the Web-based population risk-monitoring enterprise dashboards, the effectiveness of the active case finding algorithm has been validated by clinicians and caregivers in Maine. The active case finding model and associated real-time Web-based app were designed to track the evolving nature of total population risk, in a

  6. Large Truck Crash Causation Study (LTCCS)

    Data.gov (United States)

    Department of Transportation — The Large Truck* Crash Causation Study (LTCCS) is based on a three-year data collection project conducted by the Federal Motor Carrier Safety Administration (FMCSA)...

  7. A large-scale study of misophonia

    NARCIS (Netherlands)

    Rouw, R.; Erfanian, M.

    2018-01-01

    Objective We aim to elucidate misophonia, a condition in which particular sounds elicit disproportionally strong aversive reactions. Method A large online study extensively surveyed personal, developmental, and clinical characteristics of over 300 misophonics. Results Most participants indicated

  8. Design of a statewide radiation survey

    International Nuclear Information System (INIS)

    Nagda, N.L.; Koontz, M.D.; Rector, H.E.; Nifong, G.D.

    1989-01-01

    The Florida Institute of Phosphate Research (FIPR) recently sponsored a statewide survey to identify all significant land areas in Florida where the state's environmental radiation rule should be applied. Under this rule, newly constructed buildings must be tested for radiation levels unless approved construction techniques are used. Two parallel surveys - a land-based survey and a population-based survey - were designed and conducted to address the objective. Each survey included measurements in more than 3000 residences throughout the state. Other information sources that existed at the outset of the study, such as geologic profiles mapped by previous investigators and terrestrial uranium levels characterized through aerial gamma radiation surveys, were also examined. Initial data analysis efforts focused on determining the extent of evidence of radon potential for each of 67 counties in the state. Within 18 countries that were determined to have definite evidence of elevated radon potential, more detailed spatial analyses were conducted to identify areas of which the rule should apply. A total of 74 quadrangles delineated by the U.S. Geological Survey, representing about 7% of those constituting the state, were identified as having elevated radon potential and being subject to the rule

  9. Statewide Groundwater Recharge Modeling in New Mexico

    Science.gov (United States)

    Xu, F.; Cadol, D.; Newton, B. T.; Phillips, F. M.

    2017-12-01

    It is crucial to understand the rate and distribution of groundwater recharge in New Mexico because it not only largely defines a limit for water availability in this semi-arid state, but also is the least understood aspect of the state's water budget. With the goal of estimating groundwater recharge statewide, we are developing the Evapotranspiration and Recharge Model (ETRM), which uses existing spatial datasets to model the daily soil water balance over the state at a resolution of 250 m cell. The input datasets includes PRISM precipitation data, MODIS Normalized Difference Vegetation Index (NDVI), NRCS soils data, state geology data and reference ET estimates produced by Gridded Atmospheric Data downscalinG and Evapotranspiration Tools (GADGET). The current estimated recharge presents diffuse recharge only, not focused recharge as in channels or playas. Direct recharge measurements are challenging and rare, therefore we estimate diffuse recharge using a water balance approach. The ETRM simulated runoff amount was compared with USGS gauged discharge in four selected ephemeral channels: Mogollon Creek, Zuni River, the Rio Puerco above Bernardo, and the Rio Puerco above Arroyo Chico. Result showed that focused recharge is important, and basin characteristics can be linked with watershed hydrological response. As the sparse instruments in NM provide limited help in improving estimation of focused recharge by linking basin characteristics, the Walnut Gulch Experimental Watershed, which is one of the most densely gauged and monitored semiarid rangeland watershed for hydrology research purpose, is now being modeled with ETRM. Higher spatial resolution of field data is expected to enable detailed comparison of model recharge results with measured transmission losses in ephemeral channels. The final ETRM product will establish an algorithm to estimate the groundwater recharge as a water budget component of the entire state of New Mexico. Reference ET estimated by GADGET

  10. Familienfreundlichkeit im Medizinstudium in Baden-Württemberg. Ergebnisse einer landesweiten Studie [Family-friendliness in Medical Studies in Baden-Württemberg. Results of a State-wide Study

    Directory of Open Access Journals (Sweden)

    Niehues, Johanna

    2012-04-01

    Full Text Available [english] This paper describes the results of the study on “Family-friendliness of the Medical Studies in Baden-Württemberg” carried out in 2009-2011 by the working group “Family, Time policy and E-Learning” of the University Hospital of Ulm, supported by the Ministry of Science, Research and the Arts of Baden-Württemberg. This state-wide survey of the studying conditions and personal circumstances of medical students with children at the five medical schools in Baden-Württemberg aims to describe existing and necessary factors of family-friendliness. A total of 238 students with children participated in the quantitative online survey conducted during the summer semester 2010 which was based on topics from previous qualitative interviews with student parents.The data shows that even though founding a family while at university is usually planned, student parents are faced with significant compatibility issues, demonstrating the need for additional measures to individualise course organisation and to make the curriculum more flexible. At the same time, the need to significantly increase information and advisory services alongside the establishment of additional support services for student parents is discernable.The study contributes to the debate on the family-friendliness of universities and university hospitals and adds practice-oriented approaches to solutions.[german] Die vorliegende Arbeit beschreibt die Ergebnisse der im Zeitraum 2009-2011 durch die Arbeitsgruppe ‚Familie, Zeitpolitik und E-Learning’ des Universitätsklinikums Ulm durchgeführten, durch das Ministerium für Wissenschaft, Forschung und Kunst Baden-Württemberg geförderten Studie zum ‚Familienfreundlichen Studium in der Medizin in Baden-Württemberg’. Die landesweite Erhebung der Studien- und Lebensbedingungen Studierender mit Kind in der Humanmedizin an den fünf Medizinischen Fakultäten in Baden-Württemberg hat zum Ziel, bestehende und notwendige

  11. Tobacco Smoke Pollution in Hospitality Venues Before and After Passage of Statewide Smoke-Free Legislation.

    Science.gov (United States)

    Buettner-Schmidt, Kelly; Boursaw, Blake; Lobo, Marie L; Travers, Mark J

    2017-03-01

    In 2012, North Dakota enacted a comprehensive statewide law prohibiting smoking in enclosed public places. Disparities in tobacco control exist in rural areas. This study's objective was to determine the extent to which the passage of a comprehensive, statewide, smoke-free law in a predominantly rural state influenced tobacco smoke pollution in rural and nonrural venues. A longitudinal cohort design study comparing the levels of tobacco smoke pollution before and after passage of the statewide smoke-free law was conducted in 64 restaurants and bars statewide in North Dakota. Particulate matter with a median aerodynamic diameter of <2.5 μm (a valid atmospheric marker of tobacco smoke pollution) was assessed. A significant 83% reduction in tobacco smoke pollution levels occurred after passage of the law. Significant reductions in tobacco smoke pollution levels occurred in each of the rural categories; however, no difference by rurality was noted in the analysis after passage of the law, in contrast to the study before passage. To our knowledge, this was the largest, single, rural postlaw study globally. A comprehensive statewide smoke-free law implemented in North Dakota dramatically decreased the level of tobacco smoke pollution in bars and restaurants. © 2016 The Authors. Public Health Nursing Published by Wiley Periodicals, Inc.

  12. Large Deployable Reflector (LDR) feasibility study update

    Science.gov (United States)

    Alff, W. H.; Banderman, L. W.

    1983-01-01

    In 1982 a workshop was held to refine the science rationale for large deployable reflectors (LDR) and develop technology requirements that support the science rationale. At the end of the workshop, a set of LDR consensus systems requirements was established. The subject study was undertaken to update the initial LDR study using the new systems requirements. The study included mirror materials selection and configuration, thermal analysis, structural concept definition and analysis, dynamic control analysis and recommendations for further study. The primary emphasis was on the dynamic controls requirements and the sophistication of the controls system needed to meet LDR performance goals.

  13. Costs and effects of a state-wide health promotion program in primary schools in Germany – the Baden-Württemberg Study: A cluster-randomized, controlled trial

    Science.gov (United States)

    Kesztyüs, Tibor; Kilian, Reinhold; Steinacker, Jürgen M

    2017-01-01

    Aim To evaluate the cost-effectiveness of the state-wide implementation of the health promotion program “Join the Healthy Boat” in primary schools in Germany. Methods Cluster-randomized intervention trial with wait-list control group. Anthropometric data of 1733 participating children (7.1 ± 0.6 years) were taken by trained staff before and after a one year intervention period in the academic year 2010/11. Parents provided information about the health status, and the health behaviour of their children and themselves, parental anthropometrics, and socio-economic background variables. Incidence of abdominal obesity, defined as waist-to-height ratio (WHtR) ≥ 0.5, was determined. Generalized linear models were applied to account for the clustering of data within schools, and to adjust for baseline-values. Losses to follow-up and missing data were analysed. From a societal perspective, the overall costs, costs per pupil, and incremental cost-effectiveness ratio (ICER) to identify the costs per case of averted abdominal obesity were calculated. Results The final regression model for the incidence of abdominal obesity shows lower odds for the intervention group after an adjustment for grade, gender, baseline WHtR, and breakfast habits (odds ratio = 0.48, 95% CI [0.25; 0.94]). The intervention costs per child/year were €25.04. The costs per incidental case of averted abdominal obesity varied between €1515 and €1993, depending on the different dimensions of the target group. Conclusion This study demonstrates the positive effects of state-wide, school-based health promotion on incidental abdominal obesity, at affordable costs and with proven cost-effectiveness. These results should support allocative decisions of policymakers. An early start to the prevention of abdominal obesity is of particular importance because of its close relationship to non-communicable diseases. Trial registration German Clinical Trials Register (DRKS), Freiburg University, Germany

  14. Large Coil Program magnetic system design study

    International Nuclear Information System (INIS)

    Moses, S.D.; Johnson, N.E.

    1977-01-01

    The primary objective of the Large Coil Program (LCP) is to demonstrate the reliable operation of large superconducting coils to provide a basis for the design principles, materials, and fabrication techniques proposed for the toroidal magnets for the THE NEXT STEP (TNS) and other future tokamak devices. This paper documents a design study of the Large Coil Test Facility (LCTF) in which the structural response of the Toroidal Field (TF) Coils and the supporting structure was evaluated under simulated reactor conditions. The LCP test facility structural system consists of six TF Coils, twelve coil-to-coil torsional restraining beams (torque rings), a central bucking post with base, and a Pulse Coil system. The NASTRAN Finite Element Structural Analysis computer Code was utilized to determine the distribution of deflections, forces, and stresses for each of the TF Coils, torque rings, and the central bucking post. Eleven load conditions were selected to represent probable test operations. Pulse Coils suspended in the bore of the test coil were energized to simulate the pulsed field environment characteristic of the TNS reactor system. The TORMAC Computer Code was utilized to develop the magnetic forces in the TF Coils for each of the eleven loading conditions examined, with or without the Pulse Coils energized. The TORMAC computer program output forces were used directly as input load conditions for the NASTRAN analyses. Results are presented which demonstrate the reliability of the LCTF under simulated reactor operating conditions

  15. California statewide model for high-speed rail

    OpenAIRE

    Outwater, Maren; Tierney, Kevin; Bradley, Mark; Sall, Elizabeth; Kuppam, Arun; Modugala, Vamsee

    2010-01-01

    The California High Speed Rail Authority (CHSRA) and the Metropolitan Transportation Commission (MTC) have developed a new statewide model to support evaluation of high-speed rail alternatives in the State of California. This statewide model will also support future planning activities of the California Department of Transportation (Caltrans). The approach to this statewide model explicitly recognizes the unique characteristics of intraregional travel demand and interregional travel demand. A...

  16. A Large-Scale Study of Misophonia.

    Science.gov (United States)

    Rouw, Romke; Erfanian, Mercede

    2018-03-01

    We aim to elucidate misophonia, a condition in which particular sounds elicit disproportionally strong aversive reactions. A large online study extensively surveyed personal, developmental, and clinical characteristics of over 300 misophonics. Most participants indicated that their symptoms started in childhood or early teenage years. Severity of misophonic responses increases over time. One third of participants reported having family members with similar symptoms. Half of our participants reported no comorbid clinical conditions, and the other half reported a variety of conditions. Only posttraumatic stress disorder (PTSD) was related to the severity of the misophonic symptoms. Remarkably, half of the participants reported experiencing euphoric, relaxing, and tingling sensations with particular sounds or sights, a relatively unfamiliar phenomenon called autonomous sensory meridian response (ASMR). It is unlikely that another "real" underlying clinical, psychiatric, or psychological disorder can explain away the misophonia. The possible relationship with PTSD and ASMR warrants further investigation. © 2017 Wiley Periodicals, Inc.

  17. A Study of Large Transverse Momentum Phenomena

    CERN Multimedia

    2002-01-01

    This experiment studies the structure of those p-p and @*-p collisions which are characterized by a very high transverse momentum flow in the central region. Some specific items studied are:\\\\ \\\\ \\item -~~Structure of events, where the high transverse momentum is shared by charged and neutral hadron (``jets''). Transverse momentum distribution, correlations and momentum balance for such events. \\item -~~Structure of events, where the high transverse momentum is mostly carried by one identified particle. Quantum number dependence and quantum number correlations of the high transverse momentum events. \\item -~~Structure of events containing large transverse momentum leptons or lepton pairs or direct photons. \\end{enumerate}.sk -~~Study of low momentum electrons and photons. -~~Search for gluonium states. -~~Search for new and rare particles. \\\\ \\\\ A conventional C-type magnet with a 0.5 T field in the direction of the beams together with a 42-layer cylindrical drift chamber detector is used for momentum analysi...

  18. Statewide Dissemination of a Rural, Non-Chain Restaurant Intervention: Adoption, Implementation and Maintenance

    Science.gov (United States)

    Nothwehr, F.; Haines, H.; Chrisman, M.; Schultz, U.

    2014-01-01

    The obesity epidemic calls for greater dissemination of nutrition-related programs, yet there remain few studies of the dissemination process. This study, guided by elements of the RE-AIM model, describes the statewide dissemination of a simple, point-of-purchase restaurant intervention. Conducted in rural counties of the Midwest, United States,…

  19. Results of the 1992 State-Wide Business and Industry Survey.

    Science.gov (United States)

    Jarrett, Carole, Comp.; And Others

    As part of an effort to develop courses and programs that reflect California business and industry's current and future needs, two studies were performed by Solano Community College to examine statewide trends and issues related to office automation and marketing and management. In conducting the study of office automation, 5,000 surveys were…

  20. Evaluating RITES, a Statewide Math and Science Partnership Program

    Science.gov (United States)

    Murray, D. P.; Caulkins, J. L.; Burns, A. L.; de Oliveira, G.; Dooley, H.; Brand, S.; Veeger, A.

    2013-12-01

    The Rhode Island Technology-Enhanced Science project (RITES) is a NSF-MSP Program that seeks to improve science education by providing professional development to science teachers at the 5th through 12th grade levels. At it's heart, RITES is a complex, multifaceted project that is challenging to evaluate because of the nature of its goal: the development of a large, statewide partnership between higher education and K12 public school districts during a time when science education strategies and leadership are in flux. As a result, these difficulties often require flexibility and creativity regarding evaluation, study design and data collection. In addition, the research agenda of the project often overlaps with the evaluator's agenda, making collaboration and communication a crucial component of the project's success. In it's 5th year, RITES and it's evaluators have developed a large number of instruments, both qualitative and quantitative, to provide direction and feedback on the effectiveness of the project's activities. RITES personnel work closely with evaluators and researchers to obtain a measure of how RITES' 'theory-of-action' affects both student outcomes and teacher practice. Here we discuss measures of teacher and student content gains, student inquiry gains, and teacher implementation surveys. Using content questions based on AAAS and MOSART databases, teachers in the short courses and students in classrooms showed significant normalized learning gains with averages generally above 0.3. Students of RITES-trained teachers also outperformed their non-RITES peers on the inquiry-section of the NECAP test, and The results show, after controlling for race and economic status, a small but statistically significant increase in test scores for RITES students. Technology use in the classroom significantly increased for teachers who were 'expected implementers' where 'expected implementers' are those teachers who implemented RITES as the project was designed. This

  1. Software for large scale tracking studies

    International Nuclear Information System (INIS)

    Niederer, J.

    1984-05-01

    Over the past few years, Brookhaven accelerator physicists have been adapting particle tracking programs in planning local storage rings, and lately for SSC reference designs. In addition, the Laboratory is actively considering upgrades to its AGS capabilities aimed at higher proton intensity, polarized proton beams, and heavy ion acceleration. Further activity concerns heavy ion transfer, a proposed booster, and most recently design studies for a heavy ion collider to join to this complex. Circumstances have thus encouraged a search for common features among design and modeling programs and their data, and the corresponding controls efforts among present and tentative machines. Using a version of PATRICIA with nonlinear forces as a vehicle, we have experimented with formal ways to describe accelerator lattice problems to computers as well as to speed up the calculations for large storage ring models. Code treated by straightforward reorganization has served for SSC explorations. The representation work has led to a relational data base centered program, LILA, which has desirable properties for dealing with the many thousands of rapidly changing variables in tracking and other model programs. 13 references

  2. Configuration study of large wind parks

    Energy Technology Data Exchange (ETDEWEB)

    Lundberg, Stefan

    2003-07-01

    In this thesis, layouts of various large-scale wind parks, using both AC as well as DC, are investigated. Loss modelling of the wind park components as well as calculations of the energy capture of the turbines using various electrical systems are performed, and the energy production cost of the various park configurations is determined. The most interesting candidate for a DC transmission based wind park was investigated more in detail, the series DC wind park. Finally, the power quality impact in the PCC (point of common coupling) was studied. It was found that from an energy capture point of view, the difference in energy production between various wind turbine systems is very small. Of all the investigated wind park configurations, the wind park with the series connected DC wind turbines seems to have the best potential to give the lowest energy production cost, if the transmission distance is longer then 10-20 km. Regarding the series DC wind park it was found that it is the most difficult one to control. However, a control algorithm for the series park and its turbines was derived and successfully tested. Still, several more details regarding the control of the series wind park has to be dealt with.

  3. Water Quality attainment Information from Clean Water Act Statewide Statistical Surveys

    Data.gov (United States)

    U.S. Environmental Protection Agency — Designated uses assessed by statewide statistical surveys and their state and national attainment categories. Statewide statistical surveys are water quality...

  4. Water Quality Stressor Information from Clean Water Act Statewide Statistical Surveys

    Data.gov (United States)

    U.S. Environmental Protection Agency — Stressors assessed by statewide statistical surveys and their state and national attainment categories. Statewide statistical surveys are water quality assessments...

  5. 49 CFR 613.200 - Statewide transportation planning and programming.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 7 2010-10-01 2010-10-01 false Statewide transportation planning and programming. 613.200 Section 613.200 Transportation Other Regulations Relating to Transportation (Continued... Transportation Planning and Programming § 613.200 Statewide transportation planning and programming. The...

  6. A case study of three Puerto Rico-Statewide Systemic Initiative intermediate science teachers' views on and use of performance assessment

    Science.gov (United States)

    Pico, Rene Antonio, II

    The purpose of this study was to investigate how teachers perceived and used performance assessment in the science classroom. Ms. Sanchez, Mrs. Irizarry, and Mrs. Bonnin, seventh grade teachers, participated in the study. Five research questions regarding the use of performance assessment were generated from these areas of inquiry: (a) teachers' views, (b) teachers' concerns, (c) teachers' level of use, (d) teachers' perceived facilitators, and (e) teachers' perceived barriers. Qualitative research methodologies were employed to collect and analyze the data. These included the use of informal interviews, a demographic survey, the Stage of Concern Questionnaire (Hall, George and Rutherford, 1979), the Level of Use Interview protocol (Loucks et al., 1975) and the study of artifacts. Performance assessment was defined by the three teachers as a dynamic process requiring the use of manipulatives in which students are involved as working participants in their own learning. Mrs. Irizarry and Mrs. Bonnin, described performance assessment with a broader range of possible executions, implying the use of tasks that allowed teachers to observe student behavior ranging from simple written responses to work collected over time. Ms. Sanchez defined assessment mainly on the basis of the use of equipment, instruments and materials in science. Ms. Sanchez reflected low intensity in the Levels of Concerns (Hall, George and Rutherford, 1979), suggesting that she felt at ease when working with performance assessment. Mrs. Irizarry and Mrs. Bonnin reflected definite commitment with the innovation. A major similarity was found in the areas of Refocusing (SoC 6), and Collaboration (SoC 5) denoting an interest in exploring and trying new alternatives. Ms. Sanchez and Mrs. Bonnin demonstrated characteristics of a well established routine or pattern in the Level of Use (Loucks et al., 1975) of performance assessment, while Mrs. Irizarry explored alternatives further and established a

  7. Improving Maternal Care through a State-Wide Health Insurance Program: A Cost and Cost-Effectiveness Study in Rural Nigeria.

    Science.gov (United States)

    Gomez, Gabriela B; Foster, Nicola; Brals, Daniella; Nelissen, Heleen E; Bolarinwa, Oladimeji A; Hendriks, Marleen E; Boers, Alexander C; van Eck, Diederik; Rosendaal, Nicole; Adenusi, Peju; Agbede, Kayode; Akande, Tanimola M; Boele van Hensbroek, Michael; Wit, Ferdinand W; Hankins, Catherine A; Schultsz, Constance

    2015-01-01

    .9-152.3), during one-way sensitivity analyses, and when cost, quality, cost and utilization parameters of the base case scenario were changed. The sustainability of this program's scale up by the State is dependent on further investments in healthcare. This study provides evidence that the investment made by the KSHI program in rural Nigeria is likely to have been cost-effective; however, further healthcare investments are needed for this program to be successfully expanded within Kwara State. Policy makers should consider supporting financial initiatives to reduce maternal mortality tackling both supply and demand issues in the access to care.

  8. Improving Maternal Care through a State-Wide Health Insurance Program: A Cost and Cost-Effectiveness Study in Rural Nigeria.

    Directory of Open Access Journals (Sweden)

    Gabriela B Gomez

    interval 21.9-152.3, during one-way sensitivity analyses, and when cost, quality, cost and utilization parameters of the base case scenario were changed. The sustainability of this program's scale up by the State is dependent on further investments in healthcare.This study provides evidence that the investment made by the KSHI program in rural Nigeria is likely to have been cost-effective; however, further healthcare investments are needed for this program to be successfully expanded within Kwara State. Policy makers should consider supporting financial initiatives to reduce maternal mortality tackling both supply and demand issues in the access to care.

  9. Large scale study of tooth enamel

    International Nuclear Information System (INIS)

    Bodart, F.; Deconninck, G.; Martin, M.T.

    Human tooth enamel contains traces of foreign elements. The presence of these elements is related to the history and the environment of the human body and can be considered as the signature of perturbations which occur during the growth of a tooth. A map of the distribution of these traces on a large scale sample of the population will constitute a reference for further investigations of environmental effects. On hundred eighty samples of teeth were first analyzed using PIXE, backscattering and nuclear reaction techniques. The results were analyzed using statistical methods. Correlations between O, F, Na, P, Ca, Mn, Fe, Cu, Zn, Pb and Sr were observed and cluster analysis was in progress. The techniques described in the present work have been developed in order to establish a method for the exploration of very large samples of the Belgian population. (author)

  10. Large component deformation studies using videogrammetry

    International Nuclear Information System (INIS)

    Greenwood, J.A.

    1999-01-01

    Fermilab has the responsibility for developing certain components for the Large Hadron Collider (LHC), to be commissioned at CERN in 2005. As part of the development process, a referencing strategy must be created such that the position of internal active components may be known relative to external targeting. One question to be answered is the issue of dimensional stability of a part that will be transported over long distances; another is whether the external framework is coherent. This paper reviews the efforts of the designers of the component and the Lab's Alignment and Metrology Group to understand the behavior of a moderately large part, in this case a pie-shaped CSC chamber of dimensions 2 x 3 x 0.3 m , as it is positioned in various orientations relative to gravity. All measurements were made using a Geodetic Services, Inc. INCA 6.3 camera with an 18 min Nikon lens (Fig. 1) and were processed using GSI's V-STARS 4.1 software. Photogrammetry, more particularly digital videogrammetry, has shown that it can effectively service projects of this nature. When compared to optical tooling and laser tracker approaches, it is hard to imagine the full complement of difficulties videogrammetry allows one to avoid. Certainly the fact that neither the camera nor the part need to be stationary makes, photogrammetry an obvious choice. (author)

  11. Microinstability Studies for the Large Helical Device

    International Nuclear Information System (INIS)

    Rewoldt, G.; Ku, L.-P.; Tang, W.M.; Sugama, H.; Nakajima, N.; Watanabe, K.Y.; Murakami, S.; Yamada, H.; Cooper, W.A.

    2002-01-01

    Fully kinetic assessments of the stability properties of toroidal drift modes have been obtained for cases for the Large Helical Device (LHD). This calculation employs the comprehensive linear microinstability code FULL, as recently extended for nonaxisymmetric systems. The code retains the important effects in the linearized gyrokinetic equation, using the lowest-order ''ballooning representation'' for high toroidal mode number instabilities in the electrostatic limit. These effects include trapped particles, FLR, transit and bounce and magnetic drift frequency resonances, etc., for any number of plasma species. Results for toroidal drift waves destabilized by trapped electrons and ion temperature gradients are presented, using numerically-calculated three-dimensional MHD equilibria. These are reconstructed from experimental measurements. Quasilinear fluxes of particles and energy for each species are also calculated. Pairs of LHD discharges with different magnetic axis positions and with and without pellet injection are compared

  12. Statewide Transportation Engineering Warehouse for Archived Regional Data (STEWARD).

    Science.gov (United States)

    2009-12-01

    This report documents Phase III of the development and operation of a prototype for the Statewide Transportation : Engineering Warehouse for Archived Regional Data (STEWARD). It reflects the progress on the development and : operation of STEWARD sinc...

  13. WisDOT statewide customer satisfaction survey : [project brief].

    Science.gov (United States)

    2013-03-01

    The Wisconsin Department of Transportation (WisDOT) is a major public agency with numerous customers utilizing a variety of services and programs to support the entire statewide multimodal transportation system. The department also houses the Divisio...

  14. Statewide and Metropolitan Transportation Planning Processes : a TPCB Peer Exchange

    Science.gov (United States)

    2016-04-20

    This report highlights key recommendations and noteworthy practices identified at Statewide and Metropolitan Transportation Planning Processes Peer Exchange held on September 9-10, 2015 in Shepherdstown, West Virginia. This event was sponsored ...

  15. RATAN - 600 studies the large Universe

    International Nuclear Information System (INIS)

    Parijskij, Yu.N.

    1981-01-01

    The results of investigations in the range of outergalactic radioastronomy obtained using the RATAN-600 radiotelescope in 1980, are presented. The main attention is paid to the studies of radiogalaxies and, particularly, revealing the frequency dependence of radioimages. The nature of activity of radiogalactic nuclei is specified. The experimental data available prove that the nucleus of our Galaxy consists of ordinary stars and does not have massive black hole. The most profound review of the sky is carried out for the first time in the history of radioastronomy. About 3000 radiosourses were registered within the experiment. Sources with the radiation flux density about 1 mJy are registered reliably. In the range of weak fluxes (up to 1mJy), the growth of the number of sources practically ceases with the decrease in the density of the radiation flux [ru

  16. Regularized Discriminant Analysis: A Large Dimensional Study

    KAUST Repository

    Yang, Xiaoke

    2018-04-28

    In this thesis, we focus on studying the performance of general regularized discriminant analysis (RDA) classifiers. The data used for analysis is assumed to follow Gaussian mixture model with different means and covariances. RDA offers a rich class of regularization options, covering as special cases the regularized linear discriminant analysis (RLDA) and the regularized quadratic discriminant analysis (RQDA) classi ers. We analyze RDA under the double asymptotic regime where the data dimension and the training size both increase in a proportional way. This double asymptotic regime allows for application of fundamental results from random matrix theory. Under the double asymptotic regime and some mild assumptions, we show that the asymptotic classification error converges to a deterministic quantity that only depends on the data statistical parameters and dimensions. This result not only implicates some mathematical relations between the misclassification error and the class statistics, but also can be leveraged to select the optimal parameters that minimize the classification error, thus yielding the optimal classifier. Validation results on the synthetic data show a good accuracy of our theoretical findings. We also construct a general consistent estimator to approximate the true classification error in consideration of the unknown previous statistics. We benchmark the performance of our proposed consistent estimator against classical estimator on synthetic data. The observations demonstrate that the general estimator outperforms others in terms of mean squared error (MSE).

  17. A Statewide Examiniation of Mental Health Courts in Illinois: Program Characteristics and Operations

    Directory of Open Access Journals (Sweden)

    Arthur J. Lurigio

    2015-07-01

    Full Text Available This study represents the only broad-based, statewide evaluation of mental health courts (MHCs conducted to date.  Data were collected from 2010 to 2013 at each of the nine active MHC programs operating in Illinois at the start of the study. The purpose of the study was to compare and contrast the adjudicatory and supervisory models of each established Illinois MHC program by utilizing a variety of research methodologies. A four-year recidivism analysis of case-level data from three Illinois MHCs was also conducted. Illinois MHCs were largely characterized by the '10 essential elements of an MHC', such as voluntary participation, informed choice and hybrid team approaches to case manage clients. Results of the recidivism analysis suggest that MHCs compare favorably to other types of probation. Overall, findings revealed that Illinois MHCs are delivering services effectively and efficiently in a well-coordinated, client-centered team approach. Differences found among the MHCs are not evidence of significant variance from the model, and instead represent responsiveness to the unique culture of the court, the niche-filling character of the program, the expectations of the program stakeholders and the nature and extent of the local service environment.

  18. A Statewide Partnership for Implementing Inquiry Science

    Science.gov (United States)

    Lytle, Charles

    The North Carolina Infrastructure for Science Education (NC-ISE) is a statewide partnership for implementing standards-based inquiry science using exemplary curriculum materials in the public schools of North Carolina. North Carolina is the 11th most populous state in the USA with 8,000,000 residents, 117 school districts and a geographic area of 48,718 miles. NC-ISE partners include the state education agency, local school systems, three branches of the University of North Carolina, the state mathematics and science education network, businesses, and business groups. The partnership, based upon the Science for All Children model developed by the National Science Resources Centre, was initiated in 1997 for improvement in teaching and learning of science and mathematics. This research-based model has been successfully implemented in several American states during the past decade. Where effectively implemented, the model has led to significant improvements in student interest and student learning. It has also helped reduce the achievement gap between minority and non-minority students and among students from different economic levels. A key program element of the program is an annual Leadership Institute that helps teams of administrators and teachers develop a five-year strategic plan for their local systems. Currently 33 of the117 local school systems have joined the NC-ISE Program and are in various stages of implementation of inquiry science in grades K-8.

  19. Staff turnover in statewide implementation of ACT: relationship with ACT fidelity and other team characteristics

    OpenAIRE

    Rollins, Angela L.; Salyers, Michelle P.; Tsai, Jack; Lydick, Jennifer M.

    2010-01-01

    Staff turnover on assertive community treatment (ACT) teams is a poorly understood phenomenon. This study examined annual turnover and fidelity data collected in a statewide implementation of ACT over a 5-year period. Mean annual staff turnover across all observations was 30.0%. Turnover was negatively correlated with overall fidelity at Year 1 and 3. The team approach fidelity item was negatively correlated with staff turnover at Year 3. For 13 teams with 3 years of follow-up data, turnover ...

  20. 23 CFR 450.222 - Applicability of NEPA to statewide transportation plans and programs.

    Science.gov (United States)

    2010-04-01

    ... the Secretary concerning a long-range statewide transportation plan or STIP developed through the... 23 Highways 1 2010-04-01 2010-04-01 false Applicability of NEPA to statewide transportation plans... TRANSPORTATION PLANNING AND RESEARCH PLANNING ASSISTANCE AND STANDARDS Statewide Transportation Planning and...

  1. How safe are regional techniques? Evidence from large studies with ...

    African Journals Online (AJOL)

    meta-analysis are inappropriate for a proper assessment of rare events, such as neurological injury.2 Most of the references to adverse effects, particularly those associated with peripheral ... Evidence from large studies with big data.

  2. Piloting a Statewide Home Visiting Quality Improvement Learning Collaborative.

    Science.gov (United States)

    Goyal, Neera K; Rome, Martha G; Massie, Julie A; Mangeot, Colleen; Ammerman, Robert T; Breckenridge, Jye; Lannon, Carole M

    2017-02-01

    Objective To pilot test a statewide quality improvement (QI) collaborative learning network of home visiting agencies. Methods Project timeline was June 2014-May 2015. Overall objectives of this 8-month initiative were to assess the use of collaborative QI to engage local home visiting agencies and to test the use of statewide home visiting data for QI. Outcome measures were mean time from referral to first home visit, percentage of families with at least three home visits per month, mean duration of participation, and exit rate among infants learning. A statewide data system was used to generate monthly run charts. Results Mean time from referral to first home visit was 16.7 days, and 9.4% of families received ≥3 visits per month. Mean participation was 11.7 months, and the exit rate among infants learning network, agencies tested and measured changes using statewide and internal data. Potential next steps are to develop and test new metrics with current pilot sites and a larger collaborative.

  3. A guide for statewide impaired-driving task forces.

    Science.gov (United States)

    2009-09-01

    The purpose of the guide is to assist State officials and other stakeholders who are interested in establishing an : Impaired-Driving Statewide Task Force or who are exploring ways to improve their current Task Force. The guide : addresses issues suc...

  4. California Statewide Plug-In Electric Vehicle Infrastructure Assessment

    Energy Technology Data Exchange (ETDEWEB)

    Melaina, Marc; Helwig, Michael

    2014-05-01

    The California Statewide Plug-In Electric Vehicle Infrastructure Assessment conveys to interested parties the Energy Commission’s conclusions, recommendations, and intentions with respect to plug-in electric vehicle (PEV) infrastructure development. There are several relatively low-risk and high-priority electric vehicle supply equipment (EVSE) deployment options that will encourage PEV sales and

  5. Infrared, Raman and laser fluorescence studies on large molecules

    International Nuclear Information System (INIS)

    Venkateswaran, Sugandhi

    2000-01-01

    In the present thesis, infrared and Raman spectroscopic studies on large molecules, molecular assemblies and crystalline solids, as a function of temperature, pressure and added materials have been carried out. Spectral changes observed in our studies are interpreted in terms of intermolecular interaction, phase transition and conformational changes taking place in the molecules studied

  6. Statewide Inferior Vena Cava Filter Placement, Complications, and Retrievals: Epidemiology and Recent Trends.

    Science.gov (United States)

    Charalel, Resmi A; Durack, Jeremy C; Mao, Jialin; Ross, Joseph S; Meltzer, Andrew J; Sedrakyan, Art

    2018-03-01

    Public awareness of inferior vena cava (IVC) filter-related controversies has been elevated by the Food and Drug Administration (FDA) safety communication in 2010. To examine population level trends in IVC filter utilization, complications, retrieval rates, and subsequent pulmonary embolism (PE) risk. A retrospective cohort study. Patients receiving IVC filters during 2005-2014 in New York State. IVC filter-specific complications, new PE occurrences and IVC filter retrievals were evaluated as time-to-event data using Kaplan-Meier analysis. Estimated cumulative risks were obtained at various timepoints during follow-up. There were 91,873 patients receiving IVC filters between 2005 and 2014 in New York State included in the study. The average patient age was 67 years and 46.6% were male. Age-adjusted rates of IVC filter placement increased from 48 cases/100,000 in 2005 to 52 cases/100,000 in 2009, and decreased afterwards to 36 cases/100,000 in 2014. The estimated risks of having an IVC filter-related complication and filter retrieval within 1 year was 1.5% [95% confidence interval (CI), 1.4%-1.6%] and 3.5% (95% CI, 3.4%-3.6%). One-year retrieval rate was higher post-2010 when compared with pre-2010 years (hazard ratio, 2.70; 95% CI, 2.50-2.91). Among the 58,176 patients who did not have PE events before or at the time of IVC filter placement, the estimated risk of developing subsequent PE at 1 year was 2.0% (95% CI, 1.9%-2.1%). Our findings suggest that FDA communications may be effective in modifying statewide clinical practices. Given the 2% observed PE rate following prophylactic IVC filter placement, large scale pragmatic studies are needed to determine contemporary safety and effectiveness of IVC filters.

  7. WiFi RFID demonstration for resource tracking in a statewide disaster drill.

    Science.gov (United States)

    Cole, Stacey L; Siddiqui, Javeed; Harry, David J; Sandrock, Christian E

    2011-01-01

    To investigate the capabilities of Radio Frequency Identification (RFID) tracking of patients and medical equipment during a simulated disaster response scenario. RFID infrastructure was deployed at two small rural hospitals, in one large academic medical center and in two vehicles. Several item types from the mutual aid equipment list were selected for tracking during the demonstration. A central database server was installed at the UC Davis Medical Center (UCDMC) that collected RFID information from all constituent sites. The system was tested during a statewide disaster drill. During the drill, volunteers at UCDMC were selected to locate assets using the traditional method of locating resources and then using the RFID system. This study demonstrated the effectiveness of RFID infrastructure in real-time resource identification and tracking. Volunteers at UCDMC were able to locate assets substantially faster using RFID, demonstrating that real-time geolocation can be substantially more efficient and accurate than traditional manual methods. A mobile, Global Positioning System (GPS)-enabled RFID system was installed in a pediatric ambulance and connected to the central RFID database via secure cellular communication. This system is unique in that it provides for seamless region-wide tracking that adaptively uses and seamlessly integrates both outdoor cellular-based mobile tracking and indoor WiFi-based tracking. RFID tracking can provide a real-time picture of the medical situation across medical facilities and other critical locations, leading to a more coordinated deployment of resources. The RFID system deployed during this study demonstrated the potential to improve the ability to locate and track victims, healthcare professionals, and medical equipment during a region-wide disaster.

  8. Large-scale Lurgi plant would be uneconomic: study group

    Energy Technology Data Exchange (ETDEWEB)

    1964-03-21

    Gas Council and National Coal Board agreed that building of large scale Lurgi plant on the basis of study is not at present acceptable on economic grounds. The committee considered that new processes based on naphtha offered more economic sources of base and peak load production. Tables listing data provided in contractors' design studies and summary of contractors' process designs are included.

  9. Employment status matters: a statewide survey of quality-of-life, prevention behaviors, and absenteeism and presenteeism.

    Science.gov (United States)

    Merchant, James A; Kelly, Kevin M; Burmeister, Leon F; Lozier, Matt J; Amendola, Alison; Lind, David P; KcKeen, Arlinda; Slater, Tom; Hall, Jennifer L; Rohlman, Diane S; Buikema, Brenda S

    2014-07-01

    To estimate quality-of-life (QoL), primary care, health insurance, prevention behaviors, absenteeism, and presenteeism in a statewide sample of the unemployed, self-employed, and organizationally employed. A statewide survey of 1602 Iowans included items from the Centers for Disease Control and Prevention QoL and Behavioral Risk Factor Surveillance System Survey prevention behavior questionnaires used to assess employee well-being; their indicator results are related to World Health Organization's Health and Work Performance Questionnaire-derived absenteeism and presenteeism scores. The unemployed exhibited poorer QoL and prevention behaviors; the self-employed exhibited many better QoL scores due largely to better prevention behaviors than those employed by organizations. Higher QoL measures and more prevention behaviors are associated with lower absenteeism and lower presenteeism. Employment status is related to measures of well-being, which are also associated with absenteeism and presenteeism.

  10. Office-based preventive dental program and statewide trends in dental caries.

    Science.gov (United States)

    Achembong, Leo N; Kranz, Ashley M; Rozier, R Gary

    2014-04-01

    To evaluate the impact of a North Carolina Medicaid preventive dentistry program in primary care medical offices (Into the Mouths of Babes Program [IMBP]) on decayed, missing, and filled teeth (dmft) of kindergarten students statewide and in schools with a large proportion of students from low-income families. An ecologic study using panel data of 920,505 kindergarten students with 11,694 school-year observations examined the effect of the IMBP on dmft scores from 1998 to 2009. Ordinary least squares regression with fixed effects determined the association between IMBP visits per child 0 to 4 years of age per county and mean dmft scores per kindergarten student per school, controlling for school-level poverty and ethnicity, county-level Medicaid enrollment, and supply of dentists and physicians. Mean dmft per kindergarten student per school increased from 1.53 in 1998 to 1.84 in 2004, then decreased to 1.59 in 2009. The mean number of IMBP visits per child 0 to 4 years of age per county increased from 0.01 in 2000 to 0.22 in 2009. A 1-unit increase in IMBP visits per county was associated with a 0.248 (95% confidence interval, -0.40 to -0.10) decrease in dmft per kindergarten student per school. For schools with more students at high risk for dental disease, a 1-unit increase in IMBP visits was associated with a 0.320 (95% confidence interval, -0.55 to -0.09) decrease in dmft. IMBP reduced dental caries among targeted vulnerable children, which helped reduce oral health disparities among preschool-aged children in North Carolina.

  11. Pediatric Exposures to Topical Benzocaine Preparations Reported to a Statewide Poison Control System

    Directory of Open Access Journals (Sweden)

    Rais Vohra

    2017-07-01

    Full Text Available Introduction: Topical benzocaine is a local anesthetic commonly used to relieve pain caused by teething, periodontal irritation, burns, wounds, and insect bites. Oral preparations may contain benzocaine concentrations ranging from 7.5% to 20%. Pediatric exposure to such large concentrations may result in methemoglobinemia and secondarily cause anemia, cyanosis, and hypoxia. Methods: This is a retrospective study of exposures reported to a statewide poison control system. The electronic health records were queried for pediatric exposures to topical benzocaine treated at a healthcare facility from 2004 to 2014. Cases of benzocaine exposure were reviewed for demographic and clinical information, and descriptive statistical analysis was performed. Results: The query resulted in 157 cases; 58 were excluded due to co-ingestants, or miscoding of non-benzocaine exposures. Children four years of age and younger represented the majority of cases (93% with a median age of 1 year. There were 88 cases of accidental/ exploratory exposure, while 6 cases resulted from therapeutic application or error, 4 cases from adverse reactions, and 1 case from an unknown cause. Asymptomatic children accounted for 75.5% of cases, but major clinical effects were observed in 5 patients. Those with serious effects were exposed to a range of benzocaine concentrations (7.5–20%, with 4 cases reporting methemoglobin levels between 20.2%–55%. Methylene blue was administered in 4 of the cases exhibiting major effects. Conclusion: The majority of exposures were accidental ingestions by young children. Most exposures resulted in minor to no effects. However, some patients required treatment with methylene blue and admission to a critical care unit. Therapeutic application by parents or caregivers may lead to adverse effects from these commonly available products.

  12. Pediatric Exposures to Topical Benzocaine Preparations Reported to a Statewide Poison Control System.

    Science.gov (United States)

    Vohra, Rais; Huntington, Serena; Koike, Jennifer; Le, Kevin; Geller, Richard J

    2017-08-01

    Topical benzocaine is a local anesthetic commonly used to relieve pain caused by teething, periodontal irritation, burns, wounds, and insect bites. Oral preparations may contain benzocaine concentrations ranging from 7.5% to 20%. Pediatric exposure to such large concentrations may result in methemoglobinemia and secondarily cause anemia, cyanosis, and hypoxia. This is a retrospective study of exposures reported to a statewide poison control system. The electronic health records were queried for pediatric exposures to topical benzocaine treated at a healthcare facility from 2004 to 2014. Cases of benzocaine exposure were reviewed for demographic and clinical information, and descriptive statistical analysis was performed. The query resulted in 157 cases; 58 were excluded due to co-ingestants, or miscoding of non-benzocaine exposures. Children four years of age and younger represented the majority of cases (93%) with a median age of 1 year. There were 88 cases of accidental/ exploratory exposure, while 6 cases resulted from therapeutic application or error, 4 cases from adverse reactions, and 1 case from an unknown cause. Asymptomatic children accounted for 75.5% of cases, but major clinical effects were observed in 5 patients. Those with serious effects were exposed to a range of benzocaine concentrations (7.5-20%), with 4 cases reporting methemoglobin levels between 20.2%-55%. Methylene blue was administered in 4 of the cases exhibiting major effects. The majority of exposures were accidental ingestions by young children. Most exposures resulted in minor to no effects. However, some patients required treatment with methylene blue and admission to a critical care unit. Therapeutic application by parents or caregivers may lead to adverse effects from these commonly available products.

  13. A School-Based Dental Program Evaluation: Comparison to the Massachusetts Statewide Survey.

    Science.gov (United States)

    Culler, Corinna S; Kotelchuck, Milton; Declercq, Eugene; Kuhlthau, Karen; Jones, Kari; Yoder, Karen M

    2017-10-01

    School-based dental programs target high-risk communities and reduce barriers to obtaining dental services by delivering care to students in their schools. We describe the evaluation of a school-based dental program operating in Chelsea, a city north of Boston, with a low-income and largely minority population, by comparing participants' oral health to a Massachusetts oral health assessment. Standardized dental screenings were conducted for students in kindergarten, third, and sixth grades. Outcomes were compared in bivariate analysis, stratified by grade and income levels. A greater percentage of Chelsea students had untreated decay and severe treatment need than students statewide. Yet, fewer Chelsea third graders had severe treatment need, and more had dental sealants. There was no significant difference in the percentage of Chelsea students having severe treatment need or dental sealants by income level. Students participating in our program do not have lower decay levels than students statewide. However, they do have lower levels of severe treatment need, likely due to treatment referrals. Our results confirm that school-based prevention programs can lead to increased prevalence of dental sealants among high-risk populations. Results provide support for the establishment of full-service school-based programs in similar communities. © 2017, American School Health Association.

  14. Experimental study on propagation properties of large size TEM antennas

    International Nuclear Information System (INIS)

    Zhang Guowei; Wang Haiyang; Chen Weiqing; Wang Wei; Zhu Xiangqin; Xie Linshen

    2014-01-01

    The propagation properties of large size TEM antennas were studied by experiment. The size of the TEM antennas is 60 m × 20 m × 10 m and the character Impedance is 120 Ω. A kind of dielectric foil switch is designed compactly with TEM antennas which can generate double exponential waveform with altitude of 10 kV and rise time of l.2 ns. The radiated field distribution was measured. The relationship between rise time/altitude and distance were provided, and the propagation properties of large size TEM antennas were summarized. (authors)

  15. Staff turnover in statewide implementation of ACT: relationship with ACT fidelity and other team characteristics.

    Science.gov (United States)

    Rollins, Angela L; Salyers, Michelle P; Tsai, Jack; Lydick, Jennifer M

    2010-09-01

    Staff turnover on assertive community treatment (ACT) teams is a poorly understood phenomenon. This study examined annual turnover and fidelity data collected in a statewide implementation of ACT over a 5-year period. Mean annual staff turnover across all observations was 30.0%. Turnover was negatively correlated with overall fidelity at Year 1 and 3. The team approach fidelity item was negatively correlated with staff turnover at Year 3. For 13 teams with 3 years of follow-up data, turnover rates did not change over time. Most ACT staff turnover rates were comparable or better than other turnover rates reported in the mental health and substance abuse literature.

  16. Benchmarking statewide trauma mortality using Agency for Healthcare Research and Quality's patient safety indicators.

    Science.gov (United States)

    Ang, Darwin; McKenney, Mark; Norwood, Scott; Kurek, Stanley; Kimbrell, Brian; Liu, Huazhi; Ziglar, Michele; Hurst, James

    2015-09-01

    Improving clinical outcomes of trauma patients is a challenging problem at a statewide level, particularly if data from the state's registry are not publicly available. Promotion of optimal care throughout the state is not possible unless clinical benchmarks are available for comparison. Using publicly available administrative data from the State Department of Health and the Agency for Healthcare Research and Quality (AHRQ) patient safety indicators (PSIs), we sought to create a statewide method for benchmarking trauma mortality and at the same time also identifying a pattern of unique complications that have an independent influence on mortality. Data for this study were obtained from State of Florida Agency for Health Care Administration. Adult trauma patients were identified as having International Classification of Disease ninth edition codes defined by the state. Multivariate logistic regression was used to create a predictive inpatient expected mortality model. The expected value of PSIs was created using the multivariate model and their beta coefficients provided by the AHRQ. Case-mix adjusted mortality results were reported as observed to expected (O/E) ratios to examine mortality, PSIs, failure to prevent complications, and failure to rescue from death. There were 50,596 trauma patients evaluated during the study period. The overall fit of the expected mortality model was very strong at a c-statistic of 0.93. Twelve of 25 trauma centers had O/E ratios benchmarking method that screens at risk trauma centers in the state for higher than expected mortality. Stratifying mortality based on failure to prevent PSIs may identify areas of needed improvement at a statewide level. Copyright © 2015 Elsevier Inc. All rights reserved.

  17. Learning Analytics across a Statewide System

    Science.gov (United States)

    Buyarski, Catherine; Murray, Jim; Torstrick, Rebecca

    2017-01-01

    This chapter explores lessons learned from two different learning analytics efforts at a large, public, multicampus university--one internally developed and one vended platform. It raises questions about how to best use analytics to support students while keeping students responsible for their own learning and success.

  18. Design study on sodium-cooled large-scale reactor

    International Nuclear Information System (INIS)

    Shimakawa, Yoshio; Nibe, Nobuaki; Hori, Toru

    2002-05-01

    In Phase 1 of the 'Feasibility Study on Commercialized Fast Reactor Cycle Systems (F/S)', an advanced loop type reactor has been selected as a promising concept of sodium-cooled large-scale reactor, which has a possibility to fulfill the design requirements of the F/S. In Phase 2 of the F/S, it is planed to precede a preliminary conceptual design of a sodium-cooled large-scale reactor based on the design of the advanced loop type reactor. Through the design study, it is intended to construct such a plant concept that can show its attraction and competitiveness as a commercialized reactor. This report summarizes the results of the design study on the sodium-cooled large-scale reactor performed in JFY2001, which is the first year of Phase 2. In the JFY2001 design study, a plant concept has been constructed based on the design of the advanced loop type reactor, and fundamental specifications of main systems and components have been set. Furthermore, critical subjects related to safety, structural integrity, thermal hydraulics, operability, maintainability and economy have been examined and evaluated. As a result of this study, the plant concept of the sodium-cooled large-scale reactor has been constructed, which has a prospect to satisfy the economic goal (construction cost: less than 200,000yens/kWe, etc.) and has a prospect to solve the critical subjects. From now on, reflecting the results of elemental experiments, the preliminary conceptual design of this plant will be preceded toward the selection for narrowing down candidate concepts at the end of Phase 2. (author)

  19. Is bioelectrical impedance accurate for use in large epidemiological studies?

    Directory of Open Access Journals (Sweden)

    Merchant Anwar T

    2008-09-01

    Full Text Available Abstract Percentage of body fat is strongly associated with the risk of several chronic diseases but its accurate measurement is difficult. Bioelectrical impedance analysis (BIA is a relatively simple, quick and non-invasive technique, to measure body composition. It measures body fat accurately in controlled clinical conditions but its performance in the field is inconsistent. In large epidemiologic studies simpler surrogate techniques such as body mass index (BMI, waist circumference, and waist-hip ratio are frequently used instead of BIA to measure body fatness. We reviewed the rationale, theory, and technique of recently developed systems such as foot (or hand-to-foot BIA measurement, and the elements that could influence its results in large epidemiologic studies. BIA results are influenced by factors such as the environment, ethnicity, phase of menstrual cycle, and underlying medical conditions. We concluded that BIA measurements validated for specific ethnic groups, populations and conditions can accurately measure body fat in those populations, but not others and suggest that for large epdiemiological studies with diverse populations BIA may not be the appropriate choice for body composition measurement unless specific calibration equations are developed for different groups participating in the study.

  20. Study of a large scale neutron measurement channel

    International Nuclear Information System (INIS)

    Amarouayache, Anissa; Ben Hadid, Hayet.

    1982-12-01

    A large scale measurement channel allows the processing of the signal coming from an unique neutronic sensor, during three different running modes: impulses, fluctuations and current. The study described in this note includes three parts: - A theoretical study of the large scale channel and its brief description are given. The results obtained till now in that domain are presented. - The fluctuation mode is thoroughly studied and the improvements to be done are defined. The study of a fluctuation linear channel with an automatic commutation of scales is described and the results of the tests are given. In this large scale channel, the method of data processing is analogical. - To become independent of the problems generated by the use of a an analogical processing of the fluctuation signal, a digital method of data processing is tested. The validity of that method is improved. The results obtained on a test system realized according to this method are given and a preliminary plan for further research is defined [fr

  1. Genome Structural Diversity among 31 Bordetella pertussis Isolates from Two Recent U.S. Whooping Cough Statewide Epidemics.

    Science.gov (United States)

    Bowden, Katherine E; Weigand, Michael R; Peng, Yanhui; Cassiday, Pamela K; Sammons, Scott; Knipe, Kristen; Rowe, Lori A; Loparev, Vladimir; Sheth, Mili; Weening, Keeley; Tondella, M Lucia; Williams, Margaret M

    2016-01-01

    During 2010 and 2012, California and Vermont, respectively, experienced statewide epidemics of pertussis with differences seen in the demographic affected, case clinical presentation, and molecular epidemiology of the circulating strains. To overcome limitations of the current molecular typing methods for pertussis, we utilized whole-genome sequencing to gain a broader understanding of how current circulating strains are causing large epidemics. Through the use of combined next-generation sequencing technologies, this study compared de novo, single-contig genome assemblies from 31 out of 33 Bordetella pertussis isolates collected during two separate pertussis statewide epidemics and 2 resequenced vaccine strains. Final genome architecture assemblies were verified with whole-genome optical mapping. Sixteen distinct genome rearrangement profiles were observed in epidemic isolate genomes, all of which were distinct from the genome structures of the two resequenced vaccine strains. These rearrangements appear to be mediated by repetitive sequence elements, such as high-copy-number mobile genetic elements and rRNA operons. Additionally, novel and previously identified single nucleotide polymorphisms were detected in 10 virulence-related genes in the epidemic isolates. Whole-genome variation analysis identified state-specific variants, and coding regions bearing nonsynonymous mutations were classified into functional annotated orthologous groups. Comprehensive studies on whole genomes are needed to understand the resurgence of pertussis and develop novel tools to better characterize the molecular epidemiology of evolving B. pertussis populations. IMPORTANCE Pertussis, or whooping cough, is the most poorly controlled vaccine-preventable bacterial disease in the United States, which has experienced a resurgence for more than a decade. Once viewed as a monomorphic pathogen, B. pertussis strains circulating during epidemics exhibit diversity visible on a genome structural

  2. Design study on sodium cooled large-scale reactor

    International Nuclear Information System (INIS)

    Murakami, Tsutomu; Hishida, Masahiko; Kisohara, Naoyuki

    2004-07-01

    In Phase 1 of the 'Feasibility Studies on Commercialized Fast Reactor Cycle Systems (F/S)', an advanced loop type reactor has been selected as a promising concept of sodium-cooled large-scale reactor, which has a possibility to fulfill the design requirements of the F/S. In Phase 2, design improvement for further cost reduction of establishment of the plant concept has been performed. This report summarizes the results of the design study on the sodium-cooled large-scale reactor performed in JFY2003, which is the third year of Phase 2. In the JFY2003 design study, critical subjects related to safety, structural integrity and thermal hydraulics which found in the last fiscal year has been examined and the plant concept has been modified. Furthermore, fundamental specifications of main systems and components have been set and economy has been evaluated. In addition, as the interim evaluation of the candidate concept of the FBR fuel cycle is to be conducted, cost effectiveness and achievability for the development goal were evaluated and the data of the three large-scale reactor candidate concepts were prepared. As a results of this study, the plant concept of the sodium-cooled large-scale reactor has been constructed, which has a prospect to satisfy the economic goal (construction cost: less than 200,000 yens/kWe, etc.) and has a prospect to solve the critical subjects. From now on, reflecting the results of elemental experiments, the preliminary conceptual design of this plant will be preceded toward the selection for narrowing down candidate concepts at the end of Phase 2. (author)

  3. Genetic Influences on Pulmonary Function: A Large Sample Twin Study

    DEFF Research Database (Denmark)

    Ingebrigtsen, Truls S; Thomsen, Simon F; van der Sluis, Sophie

    2011-01-01

    Heritability of forced expiratory volume in one second (FEV(1)), forced vital capacity (FVC), and peak expiratory flow (PEF) has not been previously addressed in large twin studies. We evaluated the genetic contribution to individual differences observed in FEV(1), FVC, and PEF using data from...... the largest population-based twin study on spirometry. Specially trained lay interviewers with previous experience in spirometric measurements tested 4,314 Danish twins (individuals), 46-68 years of age, in their homes using a hand-held spirometer, and their flow-volume curves were evaluated. Modern variance...

  4. Experimental study on generation of large area uniform electron beam

    International Nuclear Information System (INIS)

    Tang Ying; Yi Aiping; Liu Jingru; Qian Hang; Huang Xin; Yu Li; Su Jiancang; Ding Zhenjie; Ding Yongzhong; Yu Jianguo

    2007-01-01

    In the experiment of gas laser pumped by electron beam, large area uniform electron beam is important to generate high efficiency laser output. The experimental study on generation of large area uniform electron beam with SPG-200 pulsed power generator is introduced. SPG-200 is an all-solid-state components pulsed power generator based on SOS, and its open voltage is more than 350 kV. The cathode have the area of 24 mm x 294 mm, and the anode-cathode(A-C)gap spacing is adjustable from 0 to 49 mm. The electron beam of cathode emission is transported to the laser chamber through the diode pressure foil, which sepa-rates the vacuum chamber from the laser chamber. Velvet and graphite cathodes are studied, each generates large area electron beam. The diode parameters are presented, and the uniformity of e-beam is diagnosed. The experimental results show that the diode voltage of the graphite cathode is 240-280 kV, and the diode current is 0.7-1.8 kA. The diode voltage of the velvet cathode is 200-250 kV, and the diode current is 1.5-1.7 kA. The uniformity of the velvet cathode emission is better than that of the graphite cathode. (authors)

  5. The Soft Underbelly of System Change: The Role of Leadership and Organizational Climate in Turnover during Statewide Behavioral Health Reform.

    Science.gov (United States)

    Aarons, Gregory A; Sommerfeld, David H; Willging, Cathleen E

    2011-01-01

    This study examined leadership, organizational climate, staff turnover intentions, and voluntary turnover during a large-scale statewide behavioral health system reform. The initial data collection occurred nine months after initiation of the reform with a follow-up round of data collected 18 months later. A self-administered structured assessment was completed by 190 participants (administrators, support staff, providers) employed by 14 agencies. Key variables included leadership, organizational climate, turnover intentions, turnover, and reform-related financial stress ("low" versus "high") experienced by the agencies. Analyses revealed that positive leadership was related to a stronger empowering climate in both high and low stress agencies. However, the association between more positive leadership and lower demoralizing climate was evident only in high stress agencies. For both types of agencies empowering climate was negatively associated with turnover intentions, and demoralizing climate was associated with stronger turnover intentions. Turnover intentions were positively associated with voluntary turnover. Results suggest that strong leadership is particularly important in times of system and organizational change and may reduce poor climate associated with turnover intentions and turnover. Leadership and organizational context should be addressed to retain staff during these periods of systemic change.

  6. 23 CFR 450.216 - Development and content of the statewide transportation improvement program (STIP).

    Science.gov (United States)

    2010-04-01

    ... Programming § 450.216 Development and content of the statewide transportation improvement program (STIP). (a... Equity Bonus funds; (5) Emergency relief projects (except those involving substantial functional...

  7. Study on large release frequency of nuclear power plants

    International Nuclear Information System (INIS)

    Chen Yan; Song Wei; Li Chaojun; Fu Zhiwei; Wang Zhe; Zuo Jiaxu; Tong Jiejuan

    2014-01-01

    There are several definitions of large release frequency of nuclear power plant. This paper reviews the meanings of large release and requirement of large release frequency provided by IAEA, NRC and WENRA, analyses the relationship between the meanings of large release, compares the calculations of several large release frequencies, It is different frequency that the definition of LRF is not same. Last we discuss the difference between large release frequency and large early release frequency and explore the suitable definitions of LRF for nuclear power plants in China. (authors)

  8. Preventing child maltreatment: Examination of an established statewide home-visiting program.

    Science.gov (United States)

    Chaiyachati, Barbara H; Gaither, Julie R; Hughes, Marcia; Foley-Schain, Karen; Leventhal, John M

    2018-05-01

    Although home visiting has been used in many populations in prevention efforts, the impact of scaled-up home-visiting programs on abuse and neglect remains unclear. The objective of this study was to assess the impact of voluntary participation in an established statewide home-visiting program for socially high-risk families on child maltreatment as identified by Child Protective Services (CPS). Propensity score matching was used to compare socially high-risk families with a child born between January 1, 2008 and December 31, 2011 who participated in Connecticut's home-visiting program for first-time mothers and a comparison cohort of families who were eligible for the home-visiting program but did not participate. The main outcomes were child maltreatment investigations, substantiations, and out-of-home placements by CPS between January 1, 2008 and December 31, 2013. In the unmatched sample, families who participated in home-visiting had significantly higher median risk scores (P home visiting. First substantiations also occurred later in the child's life among home-visited families. There was a trend toward decreased out-of-home placement (HR 0.73, 95% CI 0.53-1.02, P = .06). These results from a scaled-up statewide program highlight the potential of home visiting as an important approach to preventing child abuse and neglect. Copyright © 2018 Elsevier Ltd. All rights reserved.

  9. Improving Accuracy and Relevance of Race/Ethnicity Data: Results of a Statewide Collaboration in Hawaii.

    Science.gov (United States)

    Pellegrin, Karen L; Miyamura, Jill B; Ma, Carolyn; Taniguchi, Ronald

    2016-01-01

    Current race/ethnicity categories established by the U.S. Office of Management and Budget are neither reliable nor valid for understanding health disparities or for tracking improvements in this area. In Hawaii, statewide hospitals have collaborated to collect race/ethnicity data using a standardized method consistent with recommended practices that overcome the problems with the federal categories. The purpose of this observational study was to determine the impact of this collaboration on key measures of race/ethnicity documentation. After this collaborative effort, the number of standardized categories available across hospitals increased from 6 to 34, and the percent of inpatients with documented race/ethnicity increased from 88 to 96%. This improved standardized methodology is now the foundation for tracking population health indicators statewide and focusing quality improvement efforts. The approach used in Hawaii can serve as a model for other states and regions. Ultimately, the ability to standardize data collection methodology across states and regions will be needed to track improvements nationally.

  10. Developing a statewide public health initiative to reduce infant mortality in Oklahoma.

    Science.gov (United States)

    Dooley, Suzanna; Patrick, Paul; Lincoln, Alicia; Cline, Janette

    2014-01-01

    The Preparing for a Lifetime, It's Everyone's Responsibility initiative was developed to improve the health and well- being of Oklahoma's mothers and infants. The development phase included systematic data collection, extensive data analysis, and multi-disciplinary partnership development. In total, seven issues (preconception/interconception health, tobacco use, postpartum depression, breastfeeding, infant safe sleep, preterm birth, and infant injury prevention) were identified as crucial to addressing infant mortality in Oklahoma. Workgroups were created to focus on each issue. Data and media communications workgroups were added to further partner commitment and support for policy and programmatic changes across multiple agencies and programs. Leadership support, partnership, evaluation, and celebrating small successes were important factors that lead to large scale adoption and support for the state-wide initiative to reduce infant mortality.

  11. Feasibility study on large pool-type LMFBR

    International Nuclear Information System (INIS)

    1984-01-01

    A feasibility study has been conducted from 1981 FY to 1983 FY, in order to evaluate the feasibility of a large pool-type LMFBR under the Japanese seismic design condition and safety design condition, etc. This study was aimed to establish an original reactor structure concept which meets those design conditions especially required in Japan. In the first year, preceding design concepts had been reviewed and several concepts were originated to be suitable to Japan. For typical two of them being selected by preliminary analysis, test programs were planned. In the second year, more than twenty tests with basic models had been conducted under severe conditions, concurrently analytical approaches were promoted. In the last year, larger model tests were conducted and analytical methods have been verified concerning hydrodynamic effects on structure vibration, thermo-hydraulic behaviours in reactor plena and so on. Finally the reactor structure concepts for a large pool-type LMFBR have been acknowledged to be feasible in Japan. (author)

  12. Experimental study on dynamic behavior of large scale foundation, 1

    International Nuclear Information System (INIS)

    Hanada, Kazufumi; Sawada, Yoshihiro; Esashi, Yasuyuki; Ueshima, Teruyuki; Nakamura, Hideharu

    1983-01-01

    The large-sized, high performance vibrating table in the Nuclear Power Engineering Test Center is installed on a large-scale concrete foundation of length 90.9 m, width 44.8 m and maximum thickness 21 m, weighing 150,000 tons. Through the experimental study on the behavior of the foundation, which is set on gravel ground, useful information should be obtained on the siting of a nuclear power plant on the Quaternary stratum ground. The objective of research is to grasp the vibration characteristics of the foundation during the vibration of the table to evaluate the interaction between the foundation and the ground, and to evaluate an analytical method for numerically simulating the vibration behavior. In the present study, the vibration behavior of the foundation was clarified by measurement, and in order to predict the vibration behavior, the semi-infinite theory of elasticity was applied. The accuracy of this analytical method was demonstrated by comparison with the measured results. (Mori, K.)

  13. Large scale anisotropy studies with the Auger Observatory

    International Nuclear Information System (INIS)

    Santos, E.M.; Letessier-Selvon, A.

    2006-01-01

    With the increasing Auger surface array data sample of the highest energy cosmic rays, large scale anisotropy studies at this part of the spectrum become a promising path towards the understanding of the origin of ultra-high energy cosmic particles. We describe the methods underlying the search for distortions in the cosmic rays arrival directions over large angular scales, that is, bigger than those commonly employed in the search for correlations with point-like sources. The widely used tools, known as coverage maps, are described and some of the issues involved in their calculations are presented through Monte Carlo based studies. Coverage computation requires a deep knowledge on the local detection efficiency, including the influence of weather parameters like temperature and pressure. Particular attention is devoted to a new proposed method to extract the coverage, based upon the assumption of time factorization of an extensive air shower detector acceptance. We use Auger monitoring data to test the goodness of such a hypothesis. We finally show the necessity of using more than one coverage to extract any possible anisotropic pattern on the sky, by pointing to some of the biases present in commonly used methods based, for example, on the scrambling of the UTC arrival times for each event. (author)

  14. Statewide analysis of bicycle crashes : [project summary].

    Science.gov (United States)

    2017-06-01

    An extensive literature review was conducted to locate existing studies in four areas: (1) risk factors that affect the frequency and severity of bicycle crashes; (2) bicycle crash causes, patterns, and contributing factors; (3) network screening met...

  15. Preliminary design study of a large scale graphite oxidation loop

    International Nuclear Information System (INIS)

    Epel, L.G.; Majeski, S.J.; Schweitzer, D.G.; Sheehan, T.V.

    1979-08-01

    A preliminary design study of a large scale graphite oxidation loop was performed in order to assess feasibility and to estimate capital costs. The nominal design operates at 50 atmospheres helium and 1800 F with a graphite specimen 30 inches long and 10 inches in diameter. It was determined that a simple single walled design was not practical at this time because of a lack of commercially available thick walled high temperature alloys. Two alternative concepts, at reduced operating pressure, were investigated. Both were found to be readily fabricable to operate at 1800 F and capital cost estimates for these are included. A design concept, which is outside the scope of this study, was briefly considered

  16. Mammography Among Women With Severe Mental Illness: Exploring Disparities Through a Large Retrospective Cohort Study.

    Science.gov (United States)

    Thomas, Melanie; James, Monique; Vittinghoff, Eric; Creasman, Jennifer M; Schillinger, Dean; Mangurian, Christina

    2018-01-01

    This study examined mammogram screening rates among women with severe mental illness by using a socioecological framework. Because it has been shown that people with severe mental illness receive less preventive health care overall, the analysis included psychosocial predictors of mammogram screening rates in a cohort of women with severe mental illness. This retrospective cohort study (N=14,651) used existing statewide data for women ages 48-67 in California with Medicaid insurance who received treatment in the specialty mental health care system. The primary outcome of interest was evidence of breast cancer screening via mammogram. The associations of each predictor of interest with mammogram screening were evaluated by using Poisson models with robust standard errors. Across all demographic and diagnostic categories, rates of breast cancer screening in this cohort of women with severe mental illness fell below the national average. Only 26.3% (3,859/14,651) of women in the cohort received breast cancer screening in the past year. This study replicated previous findings that women with schizophrenia spectrum disorder and those with a comorbid substance use disorder are less likely to receive screening than those with other types of mental illness. In this cohort of women with severe mental illness, evidence of nonpsychiatric health care utilization was strongly associated with breast cancer screening (adjusted risk ratio=3.30, 95% confidence interval=2.61-4.16, pmental illness, such as targeted outreach to population subsets and colocation of primary care services in mental health treatment settings.

  17. Development of a State-Wide 3-D Seismic Tomography Velocity Model for California

    Science.gov (United States)

    Thurber, C. H.; Lin, G.; Zhang, H.; Hauksson, E.; Shearer, P.; Waldhauser, F.; Hardebeck, J.; Brocher, T.

    2007-12-01

    We report on progress towards the development of a state-wide tomographic model of the P-wave velocity for the crust and uppermost mantle of California. The dataset combines first arrival times from earthquakes and quarry blasts recorded on regional network stations and travel times of first arrivals from explosions and airguns recorded on profile receivers and network stations. The principal active-source datasets are Geysers-San Pablo Bay, Imperial Valley, Livermore, W. Mojave, Gilroy-Coyote Lake, Shasta region, Great Valley, Morro Bay, Mono Craters-Long Valley, PACE, S. Sierras, LARSE 1 and 2, Loma Prieta, BASIX, San Francisco Peninsula and Parkfield. Our beta-version model is coarse (uniform 30 km horizontal and variable vertical gridding) but is able to image the principal features in previous separate regional models for northern and southern California, such as the high-velocity subducting Gorda Plate, upper to middle crustal velocity highs beneath the Sierra Nevada and much of the Coast Ranges, the deep low-velocity basins of the Great Valley, Ventura, and Los Angeles, and a high- velocity body in the lower crust underlying the Great Valley. The new state-wide model has improved areal coverage compared to the previous models, and extends to greater depth due to the data at large epicentral distances. We plan a series of steps to improve the model. We are enlarging and calibrating the active-source dataset as we obtain additional picks from investigators and perform quality control analyses on the existing and new picks. We will also be adding data from more quarry blasts, mainly in northern California, following an identification and calibration procedure similar to Lin et al. (2006). Composite event construction (Lin et al., in press) will be carried out for northern California for use in conventional tomography. A major contribution of the state-wide model is the identification of earthquakes yielding arrival times at both the Northern California Seismic

  18. A Parameter Study of Large Fast Reactor Nuclear Explosion Accidents

    Energy Technology Data Exchange (ETDEWEB)

    Wiesel, J R

    1969-02-15

    An IBM-code EEM (Explosive Excursion Model) has been developed for calculating the energy releases associated with the explosive disassembly of a large fast reactor following a superprompt critical condition. The assumed failure chain of events and the possible core collapse following a fuel meltdown give the input data and initial conditions, the most important of which is the reactivity insertion rate at the moment of the explosive core disassembly. The dependence of the energy releases on the reactivity insertion rate, the Doppler reactivity feedback, the power form factor and the core size have been studied. The model enables a quick estimation of conservative values of the destructive mechanical energy releases following a nuclear explosion and gives suggestions as to how to reduce or even avoid such excursions.

  19. A Parameter Study of Large Fast Reactor Nuclear Explosion Accidents

    International Nuclear Information System (INIS)

    Wiesel, J.R.

    1969-02-01

    An IBM-code EEM (Explosive Excursion Model) has been developed for calculating the energy releases associated with the explosive disassembly of a large fast reactor following a superprompt critical condition. The assumed failure chain of events and the possible core collapse following a fuel meltdown give the input data and initial conditions, the most important of which is the reactivity insertion rate at the moment of the explosive core disassembly. The dependence of the energy releases on the reactivity insertion rate, the Doppler reactivity feedback, the power form factor and the core size have been studied. The model enables a quick estimation of conservative values of the destructive mechanical energy releases following a nuclear explosion and gives suggestions as to how to reduce or even avoid such excursions

  20. Are Statewide Data Systems Meeting the Local Institution's Needs? AIR Forum Paper 1978.

    Science.gov (United States)

    Bryson, Charles H.

    Statewide data collection systems emerged in the late sixties as the vehicle to achieving greater efficiency and accountability in higher education. The expectations of statewide systems were that they would meet the needs of various levels of management. The example presented in this paper is the Georgia management information system and its…

  1. Applying a statewide geospatial leaching tool for assessing soil vulnerability ratings for agrochemicals across the contiguous United States.

    Science.gov (United States)

    Ki, Seo Jin; Ray, Chittaranjan; Hantush, Mohamed M

    2015-06-15

    A large-scale leaching assessment tool not only illustrates soil (or groundwater) vulnerability in unmonitored areas, but also can identify areas of potential concern for agrochemical contamination. This study describes the methodology of how the statewide leaching tool in Hawaii modified recently for use with pesticides and volatile organic compounds can be extended to the national assessment of soil vulnerability ratings. For this study, the tool was updated by extending the soil and recharge maps to cover the lower 48 states in the United States (US). In addition, digital maps of annual pesticide use (at a national scale) as well as detailed soil properties and monthly recharge rates (at high spatial and temporal resolutions) were used to examine variations in the leaching (loads) of pesticides for the upper soil horizons. Results showed that the extended tool successfully delineated areas of high to low vulnerability to selected pesticides. The leaching potential was high for picloram, medium for simazine, and low to negligible for 2,4-D and glyphosate. The mass loadings of picloram moving below 0.5 m depth increased greatly in northwestern and central US that recorded its extensive use in agricultural crops. However, in addition to the amount of pesticide used, annual leaching load of atrazine was also affected by other factors that determined the intrinsic aquifer vulnerability such as soil and recharge properties. Spatial and temporal resolutions of digital maps had a great effect on the leaching potential of pesticides, requiring a trade-off between data availability and accuracy. Potential applications of this tool include the rapid, large-scale vulnerability assessments for emerging contaminants which are hard to quantify directly through vadose zone models due to lack of full environmental data. Copyright © 2015 Elsevier Ltd. All rights reserved.

  2. Design Study for a Staged Very Large Hadron Collider

    Energy Technology Data Exchange (ETDEWEB)

    Chao, Alex W.

    2002-02-27

    Particle physics makes its greatest advances with experiments at the highest energy. The only sure way to advance to a higher-energy regime is through hadron colliders--the Tevatron, the LHC, and then, beyond that, a Very Large Hadron Collider. At Snowmass-1996 [1], investigators explored the best way to build a VLHC, which they defined as a 100 TeV collider. The goals in this study are different. The current study seeks to identify the best and cheapest way to arrive at frontier-energy physics, while simultaneously starting down a path that will eventually lead to the highest-energy collisions technologically possible in any accelerator using presently conceivable technology. This study takes the first steps toward understanding the accelerator physics issues, the technological possibilities and the approximate cost of a particular model of the VLHC. It describes a staged approach that offers exciting physics at each stage for the least cost, and finally reaches an energy one-hundred times the highest energy currently achievable.

  3. Numerical studies of fermionic field theories at large-N

    International Nuclear Information System (INIS)

    Dickens, T.A.

    1987-01-01

    A description of an algorithm, which may be used to study large-N theories with or without fermions, is presented. As an initial test of the method, the spectrum of continuum QCD in 1 + 1 dimensions is determined and compared to previously obtained results. Exact solutions of 1 + 1 dimensional lattice versions of the free fermion theory, the Gross-Neveu model, and QCD are obtained. Comparison of these exact results with results from the numerical algorithm is used to test the algorithms, and more importantly, to determine the errors incurred from the approximations used in the numerical technique. Numerical studies of the above three lattice theories in higher dimensions are also presented. The results are again compared to exact solutions for free fermions and the Gross-Neveu model; perturbation theory is used to derive expansions with which the numerical results for QCD may be compared. The numerical algorithm may also be used to study the euclidean formulation of lattice gauge theories. Results for 1 + 1 dimensional euclidean lattice QCD are compared to the exact solution of this model

  4. Characteristics and Effects of a Statewide STEM Program

    Directory of Open Access Journals (Sweden)

    Jeffrey D. Weld

    2015-10-01

    Full Text Available A comprehensive statewide STEM (science, technology, engineering, mathematics reform initiative enters its fifth year in the U.S. state of Iowa. A significant proportion of the state’s pre K-12 students and teachers participate in one or more of the twenty programs offered, ranging from classroom curricular innovations to teacher professional development, and from community STEM festivals to career exploration events. An external, inter-university evaluation consortium measures annual progress of the initiative through the Iowa STEM Monitoring Project. Results show citizens to be increasingly aware of and supporting of STEM education; students to be increasingly interested in STEM as well as outperforming nonparticipating peers on state math and science tests; and teachers more confident and knowledgeable in teaching STEM. Iowa’s STEM initiative has garnered national acclaim though challenges remain with regard to expanding the participation of learners of diversity, as well as ensuring the long-term sustainability of the programs and structures that define Iowa’s statewide STEM initiative.

  5. A Statewide Survey for Container-Breeding Mosquitoes in Mississippi.

    Science.gov (United States)

    Goddard, Jerome; Moraru, Gail M; Mcinnis, Sarah J; Portugal, J Santos; Yee, Donald A; Deerman, J Hunter; Varnado, Wendy C

    2017-09-01

    Container-breeding mosquitoes are important in public health due to outbreaks of Zika, chikungunya, and dengue viruses. This paper documents the distribution of container-breeding mosquito species in Mississippi, with special emphasis on the genus Aedes. Five sites in each of the 82 Mississippi counties were sampled monthly between May 1 and August 31, 2016, and 50,109 mosquitoes in 14 species were collected. The most prevalent and widely distributed species found was Ae. albopictus, being found in all 82 counties, especially during July. A recent invasive, Ae. japonicus, seems to be spreading rapidly in Mississippi since first being discovered in the state in 2011. The most abundant Culex species collected were Cx. quinquefasciatus (found statewide), Cx. salinarius (almost exclusively in the southern portion of the state), and Cx. restuans (mostly central and southern Mississippi). Another relatively recent invasive species, Cx. coronator, was found in 20 counties, predominantly in the southern one-third of the state during late summer. Co-occurrence data of mosquito species found in the artificial containers were also documented and analyzed. Lastly, even though we sampled extensively in 410 sites across Mississippi, no larval Ae. aegypti were found. These data represent the first modern statewide survey of container species in Mississippi, and as such, allows for better public health readiness for emerging diseases and design of more effective vector control programs.

  6. Computational study of noise in a large signal transduction network

    Directory of Open Access Journals (Sweden)

    Ruohonen Keijo

    2011-06-01

    Full Text Available Abstract Background Biochemical systems are inherently noisy due to the discrete reaction events that occur in a random manner. Although noise is often perceived as a disturbing factor, the system might actually benefit from it. In order to understand the role of noise better, its quality must be studied in a quantitative manner. Computational analysis and modeling play an essential role in this demanding endeavor. Results We implemented a large nonlinear signal transduction network combining protein kinase C, mitogen-activated protein kinase, phospholipase A2, and β isoform of phospholipase C networks. We simulated the network in 300 different cellular volumes using the exact Gillespie stochastic simulation algorithm and analyzed the results in both the time and frequency domain. In order to perform simulations in a reasonable time, we used modern parallel computing techniques. The analysis revealed that time and frequency domain characteristics depend on the system volume. The simulation results also indicated that there are several kinds of noise processes in the network, all of them representing different kinds of low-frequency fluctuations. In the simulations, the power of noise decreased on all frequencies when the system volume was increased. Conclusions We concluded that basic frequency domain techniques can be applied to the analysis of simulation results produced by the Gillespie stochastic simulation algorithm. This approach is suited not only to the study of fluctuations but also to the study of pure noise processes. Noise seems to have an important role in biochemical systems and its properties can be numerically studied by simulating the reacting system in different cellular volumes. Parallel computing techniques make it possible to run massive simulations in hundreds of volumes and, as a result, accurate statistics can be obtained from computational studies.

  7. Anthropogenic hydrological cycle disturbance at a regional scale: State-wide evapotranspiration trends (1979-2015) across Nebraska, USA

    Science.gov (United States)

    Szilagyi, Jozsef

    2018-02-01

    Trends in monthly evapotranspiration (ET) rates across Nebraska, the most intensely irrigated state within the US, were calculated by the calibration-free version of the nonlinear complementary relationship of evaporation over the 1979-2015 period utilizing North American Regional Reanalysis (NARR) net radiation, 10-m wind velocity, as well as Parameter Regression Independent Slope Model (PRISM) air- and dew-point temperature data. State-averaged modeled ET rates rose by 5.5 mm decade-1 due to the presence of wide-spread large-scale irrigation projects in accordance with a 2.4 mm decade-1 increase in PRISM precipitation (P) and a simultaneous -2.8 mm decade-1 drop in United States Geological Survey's state-averaged annual streamflow rates, raising the state-wide ET to P ratio from 0.89 to 0.91 over the modeled time-period. ET rates over irrigated crops increased by 7 mm decade-1 despite a -4.4 mm decade-1 drop in precipitation rates. A similar increase in ET rates (6 mm decade-1) required 8.1 mm decade-1 increase in precipitation rates across the non-irrigated Sand Hills of Nebraska. Published NARR ET rates are unable to pick up this unusual regional trend. Since an increase in precipitation rates should normally decrease the ET ratio, as predicted by the Budyko curve, this study yields evidence on how dramatically sustained large-scale irrigation can alter the regional hydrologic cycle not only through a) trivially depleting streamflow rates and/or lowering groundwater table levels; b) suppressing precipitation locally (while enhancing it a long distance downwind), but also; c) reversing the trajectory of the regional ET ratio under generally increasing trends of precipitation.

  8. Trading studies of a very large hadron collider

    International Nuclear Information System (INIS)

    Ruggiero, A.G.

    1996-01-01

    The authors have shown that the design of the ELOISATRON can be approached in five separate steps. In this report they deal with the two major issues of the collider: the size and the strength of the superconducting magnets. The reference design of the SSC calls for a collider circumference of 86 km. It represents the largest size that until recently was judged feasible. The reference design of the LHC requires a bending field of 9 Tesla, that industries are presently determined to demonstrate. Clearly the large size of the project presents problem with magnet tolerances, and collider operation and management. The high field of the superconducting magnets needs to be demonstrated, and the high-field option in excess of 9 Tesla requires extensive research and development. It is obvious from the start that, if the ELOISATRON has to allow large beam energies, the circumference has also to be larger than that of the SSC, probably of few hundred kilometers. On the other end, Tevatron, RHIC and SSC type of superconducting magnets have been built and demonstrated on a large scale and proven to be cost effective and reliable. Their field, nevertheless, hardly can exceed a value of 7.5 Tesla, without major modifications that need to be studied. The LHC type of magnets may be capable of 9 Tesla, but they are being investigated presently by the European industries. It is desired that if one wants to keep the size of the ring under reasonable limits, a somewhat higher bending field is required for the ELOISATRON, especially if one wants also to take advantage of the synchrotron radiation effects. A field value of 13 Tesla, twice the value of the SSC superconducting magnets, has recently been proposed, but it clearly needs a robust program of research and development. This magnet will not probably be of the RHIC/SSC type and not even of the LHC type. It will have to be designed and conceived anew. In the following they examine two possible approaches. In the first approach

  9. Large Eddy Simulation Study for Fluid Disintegration and Mixing

    Science.gov (United States)

    Bellan, Josette; Taskinoglu, Ezgi

    2011-01-01

    A new modeling approach is based on the concept of large eddy simulation (LES) within which the large scales are computed and the small scales are modeled. The new approach is expected to retain the fidelity of the physics while also being computationally efficient. Typically, only models for the small-scale fluxes of momentum, species, and enthalpy are used to reintroduce in the simulation the physics lost because the computation only resolves the large scales. These models are called subgrid (SGS) models because they operate at a scale smaller than the LES grid. In a previous study of thermodynamically supercritical fluid disintegration and mixing, additional small-scale terms, one in the momentum and one in the energy conservation equations, were identified as requiring modeling. These additional terms were due to the tight coupling between dynamics and real-gas thermodynamics. It was inferred that if these terms would not be modeled, the high density-gradient magnitude regions, experimentally identified as a characteristic feature of these flows, would not be accurately predicted without the additional term in the momentum equation; these high density-gradient magnitude regions were experimentally shown to redistribute turbulence in the flow. And it was also inferred that without the additional term in the energy equation, the heat flux magnitude could not be accurately predicted; the heat flux to the wall of combustion devices is a crucial quantity that determined necessary wall material properties. The present work involves situations where only the term in the momentum equation is important. Without this additional term in the momentum equation, neither the SGS-flux constant-coefficient Smagorinsky model nor the SGS-flux constant-coefficient Gradient model could reproduce in LES the pressure field or the high density-gradient magnitude regions; the SGS-flux constant- coefficient Scale-Similarity model was the most successful in this endeavor although not

  10. Variations in statewide water quality of New Jersey streams, water years 1998-2009

    Science.gov (United States)

    Heckathorn, Heather A.; Deetz, Anna C.

    2012-01-01

    Statistical analyses were conducted for six water-quality constituents measured at 371 surface-water-quality stations during water years 1998-2009 to determine changes in concentrations over time. This study examined year-round concentrations of total dissolved solids, dissolved nitrite plus nitrate, dissolved phosphorus, total phosphorus, and total nitrogen; concentrations of dissolved chloride were measured only from January to March. All the water-quality data analyzed were collected by the New Jersey Department of Environmental Protection and the U.S. Geological Survey as part of the cooperative Ambient Surface-Water-Quality Monitoring Network. Stations were divided into groups according to the 1-year or 2-year period that the stations were part of the Ambient Surface-Water-Quality Monitoring Network. Data were obtained from the eight groups of Statewide Status stations for water years 1998, 1999, 2000, 2001-02, 2003-04, 2005-06, 2007-08, and 2009. The data from each group were compared to the data from each of the other groups and to baseline data obtained from Background stations unaffected by human activity that were sampled during the same time periods. The Kruskal-Wallis test was used to determine whether median concentrations of a selected water-quality constituent measured in a particular 1-year or 2-year group were different from those measured in other 1-year or 2-year groups. If the median concentrations were found to differ among years or groups of years, then Tukey's multiple comparison test on ranks was used to identify those years with different or equal concentrations of water-quality constituents. A significance level of 0.05 was selected to indicate significant changes in median concentrations of water-quality constituents. More variations in the median concentrations of water-quality constituents were observed at Statewide Status stations (randomly chosen stations scattered throughout the State of New Jersey) than at Background stations

  11. The smoking ban next door: do hospitality businesses in border areas have reduced sales after a statewide smoke-free policy?

    Science.gov (United States)

    Klein, Elizabeth G; Hood, Nancy E

    2015-01-01

    Despite numerous studies demonstrating no significant economic effects on hospitality businesses following a statewide smoke-free (SF) policy, regional concerns suggest that areas near states without SF policies may experience a loss of hospitality sales across the border. The present study evaluated the impact of Ohio's statewide SF policy on taxable restaurant and bar sales in border and non-border areas. Spline regression analysis was used to assess changes in monthly taxable sales at the county level in full-service restaurants and bars in Ohio. Data were analyzed from four years prior to policy implementation to three years post-policy. Change in the differences in the slope of taxable sales for border (n = 21) and non-border (n = 67) counties were evaluated for changes following the statewide SF policy enforcement, adjusted for unemployment rates, general trends in the hospitality sector, and seasonality. After adjusting for covariates, there was no statistically significant change in the difference in slope for taxable sales for either restaurants (β = 0.9, p = 0.09) or bars (β = 0.2, p = 0.07) following the SF policy for border areas compared to non-border areas of Ohio. Border regions in Ohio did not experience a significant change in bar and restaurant sales compared to non-border areas following a statewide SF policy. Results support that Ohio's statewide SF policy did not impact these two areas differently, and provide additional evidence for the continued use of SF policies to provide protection from exposure to secondhand smoke for both workers and the general public. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  12. Developing and maintaining state-wide adolescent pregnancy prevention coalitions: a preliminary investigation.

    Science.gov (United States)

    Nezlek, J B; Galano, J

    1993-09-01

    This paper presents the results of a study of state-wide adolescent pregnancy prevention coalitions. Key informants in five states throughout the southern United States were given semi-structured interviews regarding the adolescent pregnancy prevention coalitions in their states. From these interviews and other documents, conclusions were drawn regarding the nature and importance of the environments within which these coalitions operate, the universe of activities in which coalitions engage, and the stages of development of these coalitions. Katz and Kahn's model of social organizations served as the basis for understanding coalitions in terms of these three considerations. Future research should consider the utility of organizational models that can explain more fully the organization--committee hybrid structure that tends to characterize these coalitions.

  13. New Mexico statewide geothermal energy program. Final technical report

    Energy Technology Data Exchange (ETDEWEB)

    Icerman, L.; Parker, S.K. (ed.)

    1988-04-01

    This report summarizes the results of geothermal energy resource assessment work conducted by the New Mexico Statewide Geothermal Energy Program during the period September 7, 1984, through February 29, 1988, under the sponsorship of the US Dept. of Energy and the State of New Mexico Research and Development Institute. The research program was administered by the New Mexico Research and Development Institute and was conducted by professional staff members at New Mexico State University and Lightning Dock Geothermal, Inc. The report is divided into four chapters, which correspond to the principal tasks delineated in the above grant. This work extends the knowledge of the geothermal energy resource base in southern New Mexico with the potential for commercial applications.

  14. Statewide Policy Change in Pediatric Dental Care, and the Impact on Pediatric Dental and Physician Visits.

    Science.gov (United States)

    Zlotnick, Cheryl; Tam, Tammy; Ye, Yu

    2017-10-01

    Introduction In 2007, the California signed legislation mandating a dental visit for all children entering kindergarten or first grade; no such mandate was made for physician visits. This study examines the impact of this policy change on the risk factors associated with obtaining pediatric dental and physician health care visits. Methods Every 2 years, California Health Interview Survey conducts a statewide survey on a representative community sample. This cross-sectional study took advantage of these data to conduct a "natural experiment" assessing the impact of this policy change on both pediatric physician and dental care visits in the past year. Samples included surveys of adults and children (ages 5-11) on years 2005 (n = 5096), 2007 (n = 4324) and 2009 (n = 4100). Results Although few changes in risk factors were noted in pediatric physician visits, a gradual decrease in risk factors was found in pediatric dental visits from 2005 to 2009. Report of no dental visit was less likely for: younger children (OR -0.81, CI 0.75-0.88), insured children (OR 0.34, CI 0.22-0.53), and children who had a physician's visit last year (OR 0.37, CI 0.25-0.53) in 2005. By 2007, absence of insurance was the only risk factor related to having no dental visit (OR 0.34, CI 0.19-0.61). By 2009, no a priori measured risk factors were associated with not having a dental visit for children aged 5-11 years. Conclusions A statewide policy mandating pediatric dental visits appears to have reduced disparities. A policy for medical care may contribute to similar benefits.

  15. Implementing Statewide Severe Maternal Morbidity Review: The Illinois Experience.

    Science.gov (United States)

    Koch, Abigail R; Roesch, Pamela T; Garland, Caitlin E; Geller, Stacie E

    2018-03-07

    Severe maternal morbidity (SMM) rates in the United States more than doubled between 1998 and 2010. Advanced maternal age and chronic comorbidities do not completely explain the increase in SMM or how to effectively address it. The Centers for Disease Control and Prevention and American College of Obstetricians and Gynecologists have called for facility-level multidisciplinary review of SMM for potential preventability and have issued implementation guidelines. Within Illinois, SMM was identified as any intensive or critical care unit admission and/or 4 or more units of packed red blood cells transfused at any time from conception through 42 days postpartum. All cases meeting this definition were counted during statewide surveillance. Cases were selected for review on the basis of their potential to yield insights into factors contributing to preventable SMM or best practices preventing further morbidity or death. If the SMM review committee deemed a case potentially preventable, it identified specific factors associated with missed opportunities and made actionable recommendations for quality improvement. Approximately 1100 cases of SMM were identified from July 1, 2016, to June 30, 2017, yielding a rate of 76 SMM cases per 10 000 pregnancies. Reviews were conducted on 142 SMM cases. Most SMM cases occurred during delivery hospitalization and more than half were delivered by cesarean section. Hemorrhage was the primary cause of SMM (>50% of the cases). Facility-level SMM review was feasible and acceptable in statewide implementation. States that are planning SMM reviews across obstetric facilities should permit ample time for translation of recommendations to practice. Although continued maternal mortality reviews are valuable, they are not sufficient to address the increasing rates of SMM and maternal death. In-depth multidisciplinary review offers the potential to identify factors associated with SMM and interventions to prevent women from moving along the

  16. Vibration amplitude rule study for rotor under large time scale

    International Nuclear Information System (INIS)

    Yang Xuan; Zuo Jianli; Duan Changcheng

    2014-01-01

    The rotor is an important part of the rotating machinery; its vibration performance is one of the important factors affecting the service life. This paper presents both theoretical analyses and experimental demonstrations of the vibration rule of the rotor under large time scales. The rule can be used for the service life estimation of the rotor. (authors)

  17. Study of grounding system of large tokamak device JT-60

    International Nuclear Information System (INIS)

    Arakawa, Kiyotsugu; Shimada, Ryuichi; Kishimoto, Hiroshi; Yabuno, Kohei; Ishigaki, Yukio.

    1982-01-01

    In the critical plasma testing facility JT-60 constructed by the Japan Atomic Energy Research Institute, high voltage, large current is required in an instant. Accordingly, for the protection of human bodies and the equipment, and for realizing the stable operation of the complex, precise control and measurement system, a large scale facility of grounding system is required. In case of the JT-60 experimental facility, the equipments with different functions in separate buildings are connected, therefore, it is an important point to avoid high potential difference between buildings. In the grounding system for the JT-60, a reticulate grounding electrode is laid for each building, and these electrodes are connected with a low impedance metallic duct called grounding trunk line. The power supply cables for various magnetic field coils, control lines and measurement lines are laid in the duct. It is a large problem to grasp quantitatively the effect of a grounding trunk line by analysis. The authors analyzed the phenomenon that large current flows into a grounding system by lightning strike or grounding. The fundamental construction of the grounding system for the JT-60, the condition for the analysis and the result of simulation are reported. (Kako, I.)

  18. A "What If" Approach to Academic Facilities Utilization. Proceedings of Statewide Higher Education Conference - Academic Planning, Facilities, Finance, Institutional Studies (Pigeon Lake Field Station, Drummond, Wis., June 3-6, 1968).

    Science.gov (United States)

    Ansfield, Paul J.

    Consideration is given to a computer technology approach for studying and developing the best utilization pattern for any complex of academic facilities. The approach basically involves simulating a variety of possible class schedules and then decisively implementing the one schedule that best approximates the existing standard for utilization and…

  19. Volume measurement study for large scale input accountancy tank

    International Nuclear Information System (INIS)

    Uchikoshi, Seiji; Watanabe, Yuichi; Tsujino, Takeshi

    1999-01-01

    Large Scale Tank Calibration (LASTAC) facility, including an experimental tank which has the same volume and structure as the input accountancy tank of Rokkasho Reprocessing Plant (RRP) was constructed in Nuclear Material Control Center of Japan. Demonstration experiments have been carried out to evaluate a precision of solution volume measurement and to establish the procedure of highly accurate pressure measurement for a large scale tank with dip-tube bubbler probe system to be applied to the input accountancy tank of RRP. Solution volume in a tank is determined from substitution the solution level for the calibration function obtained in advance, which express a relation between the solution level and its volume in the tank. Therefore, precise solution volume measurement needs a precise calibration function that is determined carefully. The LASTAC calibration experiments using pure water showed good result in reproducibility. (J.P.N.)

  20. Design study on divertor plates of Large Helical Device (LHD)

    International Nuclear Information System (INIS)

    Noda, N.; Kubota, Y.; Sagara, A.

    1992-10-01

    A conceptual design has been completed for the divertor plates of the Large Helical Device (LHD, R = 3.9 m, a p = 50 ∼ 60 cm, B h = 3 ∼ 4T/ superconducting coils of NbTi) and the detailed technical design is now in progress. The design concept and the status of research and development (R and D) programs are described. (author)

  1. Similitude and scaling of large structural elements: Case study

    Directory of Open Access Journals (Sweden)

    M. Shehadeh

    2015-06-01

    Full Text Available Scaled down models are widely used for experimental investigations of large structures due to the limitation in the capacities of testing facilities along with the expenses of the experimentation. The modeling accuracy depends upon the model material properties, fabrication accuracy and loading techniques. In the present work the Buckingham π theorem is used to develop the relations (i.e. geometry, loading and properties between the model and a large structural element as that is present in the huge existing petroleum oil drilling rigs. The model is to be designed, loaded and treated according to a set of similitude requirements that relate the model to the large structural element. Three independent scale factors which represent three fundamental dimensions, namely mass, length and time need to be selected for designing the scaled down model. Numerical prediction of the stress distribution within the model and its elastic deformation under steady loading is to be made. The results are compared with those obtained from the full scale structure numerical computations. The effect of scaled down model size and material on the accuracy of the modeling technique is thoroughly examined.

  2. Ion beam analysis techniques applied to large scale pollution studies

    Energy Technology Data Exchange (ETDEWEB)

    Cohen, D D; Bailey, G; Martin, J; Garton, D; Noorman, H; Stelcer, E; Johnson, P [Australian Nuclear Science and Technology Organisation, Lucas Heights, NSW (Australia)

    1994-12-31

    Ion Beam Analysis (IBA) techniques are ideally suited to analyse the thousands of filter papers a year that may originate from a large scale aerosol sampling network. They are fast multi-elemental and, for the most part, non-destructive so other analytical methods such as neutron activation and ion chromatography can be performed afterwards. ANSTO in collaboration with the NSW EPA, Pacific Power and the Universities of NSW and Macquarie has established a large area fine aerosol sampling network covering nearly 80,000 square kilometres of NSW with 25 fine particle samplers. This network known as ASP was funded by the Energy Research and Development Corporation (ERDC) and commenced sampling on 1 July 1991. The cyclone sampler at each site has a 2.5 {mu}m particle diameter cut off and runs for 24 hours every Sunday and Wednesday using one Gillman 25mm diameter stretched Teflon filter for each day. These filters are ideal targets for ion beam analysis work. Currently ANSTO receives 300 filters per month from this network for analysis using its accelerator based ion beam techniques on the 3 MV Van de Graaff accelerator. One week a month of accelerator time is dedicated to this analysis. Four simultaneous accelerator based IBA techniques are used at ANSTO, to analyse for the following 24 elements: H, C, N, O, F, Na, Al, Si, P, S, Cl, K, Ca, Ti, V, Cr, Mn, Fe, Cu, Ni, Co, Zn, Br and Pb. The IBA techniques were proved invaluable in identifying sources of fine particles and their spatial and seasonal variations accross the large area sampled by the ASP network. 3 figs.

  3. Ion beam analysis techniques applied to large scale pollution studies

    Energy Technology Data Exchange (ETDEWEB)

    Cohen, D.D.; Bailey, G.; Martin, J.; Garton, D.; Noorman, H.; Stelcer, E.; Johnson, P. [Australian Nuclear Science and Technology Organisation, Lucas Heights, NSW (Australia)

    1993-12-31

    Ion Beam Analysis (IBA) techniques are ideally suited to analyse the thousands of filter papers a year that may originate from a large scale aerosol sampling network. They are fast multi-elemental and, for the most part, non-destructive so other analytical methods such as neutron activation and ion chromatography can be performed afterwards. ANSTO in collaboration with the NSW EPA, Pacific Power and the Universities of NSW and Macquarie has established a large area fine aerosol sampling network covering nearly 80,000 square kilometres of NSW with 25 fine particle samplers. This network known as ASP was funded by the Energy Research and Development Corporation (ERDC) and commenced sampling on 1 July 1991. The cyclone sampler at each site has a 2.5 {mu}m particle diameter cut off and runs for 24 hours every Sunday and Wednesday using one Gillman 25mm diameter stretched Teflon filter for each day. These filters are ideal targets for ion beam analysis work. Currently ANSTO receives 300 filters per month from this network for analysis using its accelerator based ion beam techniques on the 3 MV Van de Graaff accelerator. One week a month of accelerator time is dedicated to this analysis. Four simultaneous accelerator based IBA techniques are used at ANSTO, to analyse for the following 24 elements: H, C, N, O, F, Na, Al, Si, P, S, Cl, K, Ca, Ti, V, Cr, Mn, Fe, Cu, Ni, Co, Zn, Br and Pb. The IBA techniques were proved invaluable in identifying sources of fine particles and their spatial and seasonal variations accross the large area sampled by the ASP network. 3 figs.

  4. Uniformity studies in large area triple-GEM based detectors

    Energy Technology Data Exchange (ETDEWEB)

    Akl, M. Abi [Science Program, Texas A& M University at Qatar, PO Box 23874, Doha (Qatar); Bouhali, O., E-mail: othmane.bouhali@qatar.tamu.edu [Science Program, Texas A& M University at Qatar, PO Box 23874, Doha (Qatar); Qatar Computing Research Institute, Hamad Bin Khalifa University, PO Box 5825, Doha (Qatar); Castaneda, A.; Maghrbi, Y.; Mohamed, T. [Science Program, Texas A& M University at Qatar, PO Box 23874, Doha (Qatar)

    2016-10-01

    Gas Electron Multiplier (GEM) based detectors have been used in many applications since their introduction in 1997. Large areas, e.g. exceeding 30×30 cm{sup 2}, of GEM detectors are foreseen in future experiments which puts stringent requirements on the uniformity of response across the detection area. We investigate the effect of small variations of several parameters that could affect the uniformity. Parameters such as the anode pitch, the gas gap, the size and the shape of the holes are investigated. Simulation results are presented and compared to previous experimental data.

  5. Development of a statewide motorcycle safety plan for Texas : technical report.

    Science.gov (United States)

    2013-02-01

    The objective of this research project was to develop a statewide plan to reduce motorcycle crashes and : injuries in the state of Texas. The project included a review of published literature on current and proposed : countermeasures for reducing the...

  6. Statewide Transportation Improvement program 2011-2014 : sorted by MPO and RPA.

    Science.gov (United States)

    2010-01-01

    Iowas Statewide Transportation Improvement Program (STIP) has been : developed in conformance with the guidelines prescribed by 23 USC and 49 : USC. The STIP is generated to provide the Federal Highway Administration : (FHWA) and Federal Transit A...

  7. Statewide Transportation Improvement Program 2010-2013 : sorted by MPO and RPA.

    Science.gov (United States)

    2006-01-01

    Iowas Statewide Transportation Improvement Program (STIP) has been : developed in conformance with the guidelines prescribed by 23 USC. The : STIP is generated to provide the Federal Highway Administration (FHWA) and : Federal Transit Administrati...

  8. Statewide Transportation Improvement Program 2012-2015 : sorted by MPO and RPA.

    Science.gov (United States)

    2011-01-01

    Iowas Statewide Transportation Improvement Program (STIP) has been : developed in conformance with the guidelines prescribed by 23 USC and 49 : USC. The STIP is generated to provide the Federal Highway Administration : (FHWA) and Federal Transit A...

  9. Preliminary concept for statewide intercity bus and rail transit system : priority corridor ranking and analysis.

    Science.gov (United States)

    2009-03-01

    This product summarizes the preliminary concept and priority corridors for development of a potential : statewide intercity bus and rail network. The concept is based upon the results of Tasks 1 through 5 of Texas : Department of Transportation Proje...

  10. Comfort Study of Office Buildings with Large Glazed Areas

    Directory of Open Access Journals (Sweden)

    Violeta Motuzienė

    2017-09-01

    Full Text Available In the buildings with large glazed areas the biggest problem is the space overheating during the warm season. This causes increased energy demand for cooling. The survey was carried out during the warm and cold seasons in two office buildings with large glazed areas. The methodology was prepared for evaluating indoor climate parameters using objective and subjective evaluation. The measurements have shown that there are problems with lighting in workplaces of both buildings during both the warm and cold seasons. The biggest problem is too dry air during the cold period, an acceptable temperature is also not always in the building No. 2. The survey has shown that some employees are dissatisfied with the indoor climate in the workplace, the bigger dissatisfaction is in building No. 2. Assessing according to the O. Fanger methodology was obtained that the number of PPD is in the normal range during the cold period, whereas close to the limit when the building can not be operated in the warm period.

  11. Exploratory studies into seasonal flow forecasting potential for large lakes

    Science.gov (United States)

    Sene, Kevin; Tych, Wlodek; Beven, Keith

    2018-01-01

    In seasonal flow forecasting applications, one factor which can help predictability is a significant hydrological response time between rainfall and flows. On account of storage influences, large lakes therefore provide a useful test case although, due to the spatial scales involved, there are a number of modelling challenges related to data availability and understanding the individual components in the water balance. Here some possible model structures are investigated using a range of stochastic regression and transfer function techniques with additional insights gained from simple analytical approximations. The methods were evaluated using records for two of the largest lakes in the world - Lake Malawi and Lake Victoria - with forecast skill demonstrated several months ahead using water balance models formulated in terms of net inflows. In both cases slight improvements were obtained for lead times up to 4-5 months from including climate indices in the data assimilation component. The paper concludes with a discussion of the relevance of the results to operational flow forecasting systems for other large lakes.

  12. Variation in the use of advanced imaging at the time of breast cancer diagnosis in a statewide registry.

    Science.gov (United States)

    Henry, N Lynn; Braun, Thomas M; Breslin, Tara M; Gorski, David H; Silver, Samuel M; Griggs, Jennifer J

    2017-08-01

    Although national guidelines do not recommend extent of disease imaging for patients with newly diagnosed early stage breast cancer given that the harm outweighs the benefits, high rates of testing have been documented. The 2012 Choosing Wisely guidelines specifically addressed this issue. We examined the change over time in imaging use across a statewide collaborative, as well as the reasons for performing imaging and the impact on cost of care. Clinicopathologic data and use of advanced imaging tests (positron emission tomography, computed tomography, and bone scan) were abstracted from the medical records of patients treated at 25 participating sites in the Michigan Breast Oncology Quality Initiative (MiBOQI). For patients diagnosed in 2014 and 2015, reasons for testing were abstracted from the medical record. Of the 34,078 patients diagnosed with stage 0-II breast cancer between 2008 and 2015 in MiBOQI, 6853 (20.1%) underwent testing with at least 1 imaging modality in the 90 days after diagnosis. There was considerable variability in rates of testing across the 25 sites for all stages of disease. Between 2008 and 2015, testing decreased over time for patients with stage 0-IIA disease (all P diagnosis decreased over time in a large statewide collaborative. Additional interventions are warranted to further reduce rates of unnecessary imaging to improve quality of care for patients with breast cancer. Cancer 2017;123:2975-83. © 2017 American Cancer Society. © 2017 American Cancer Society.

  13. Study on reasonable curtailment rate of large scale renewable energy

    Science.gov (United States)

    Li, Nan; Yuan, Bo; Zhang, Fuqiang

    2018-02-01

    Energy curtailment rate of renewable energy generation is an important indicator to measure renewable energy consumption, it is also an important parameters to determine the other power sources and grids arrangement in the planning stage. In general, to consume the spike power of the renewable energy which is just a small proportion, it is necessary to dispatch a large number of peaking resources, which will reduce the safety and stability of the system. In planning aspect, if it is allowed to give up a certain amount of renewable energy, overall peaking demand of the system will be reduced, the peak power supply construction can be put off to avoid the expensive cost of marginal absorption. In this paper, we introduce the reasonable energy curtailment rate into the power system planning, and use the GESP power planning software, conclude that the reasonable energy curtailment rate of the regional grids in China is 3% -10% in 2020.

  14. Free-boundary equilibrium studies for the large helical device

    International Nuclear Information System (INIS)

    Gardner, H.J.; Ichiguchi, K.

    1993-06-01

    A free-boundary version of the VMEC three-dimensional equilibrium code, together with a code, DIAGNO, to determine the response to a set of magnetic diagnostic coils has been applied to the Large Helical Device. Two sequences of equilibria were considered: one where an external vertical field was used to keep the plasma centered and another where the outwardly shifting plasma was truncated by a limiter. The predictions of a simple cylindrical model have been verified for a diamagnetic loop. A set of simple response curves has been obtained which should be useful for the analysis and control of the finite plasma. The ideal Mercier criterion suggests that the centered plasma might be more stable. (author)

  15. Design studies of a depth encoding large aperture PET camera

    International Nuclear Information System (INIS)

    Moisan, C.; Rogers, J.G.; Buckley, K.R.; Ruth, T.J.; Stazyk, M.W.; Tsang, G.

    1994-10-01

    The feasibility of a wholebody PET tomograph with the capacity to correct for the parallax error induced by the Depth-Of-Interaction of γ-rays is assessed through simulation. The experimental energy, depth, and transverse position resolutions of BGO block detector candidates are the main inputs to a simulation that predicts the point source resolution of the Depth Encoding Large Aperture Camera (DELAC). The results indicate that a measured depth resolution of 7 mm (FWHM) is sufficient to correct a substantial part of the parallax error for a point source at the edge of the Field-Of-View. A search for the block specifications and camera ring radius that would optimize the spatial resolution and its uniformity across the Field-Of-View is also presented. (author). 10 refs., 1 tab., 5 figs

  16. Cooldown and Warmup Studies for the Large Hadron Collider

    CERN Document Server

    Lebrun, P; Tavian, L; Wagner, U

    1998-01-01

    The Large Hadron Collider (LHC), currently under construction at CERN, will make use of superconducting magnets operating in superfluid helium below 2 K. The LHC ring is divided in 8 sectors, each of them cooled by a refrigerator of 18 kW at 4.5 K equivalent cooling power. For the cooldown and warmup of a 3.3 km long LHC sector, the flow available above 80 K per refrigerator is 770 g/s and the cor responding capacity is 600 kW. This paper presents the results of cooldown and warmup simulations, as concerns time delays, temperature difference across magnets, available power and flow-rates, and estimates of energy and liquid nitrogen consumption.

  17. Camera memory study for large space telescope. [charge coupled devices

    Science.gov (United States)

    Hoffman, C. P.; Brewer, J. E.; Brager, E. A.; Farnsworth, D. L.

    1975-01-01

    Specifications were developed for a memory system to be used as the storage media for camera detectors on the large space telescope (LST) satellite. Detectors with limited internal storage time such as intensities charge coupled devices and silicon intensified targets are implied. The general characteristics are reported of different approaches to the memory system with comparisons made within the guidelines set forth for the LST application. Priority ordering of comparisons is on the basis of cost, reliability, power, and physical characteristics. Specific rationales are provided for the rejection of unsuitable memory technologies. A recommended technology was selected and used to establish specifications for a breadboard memory. Procurement scheduling is provided for delivery of system breadboards in 1976, prototypes in 1978, and space qualified units in 1980.

  18. Large Scale Simulation Platform for NODES Validation Study

    Energy Technology Data Exchange (ETDEWEB)

    Sotorrio, P. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Qin, Y. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Min, L. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2017-04-27

    This report summarizes the Large Scale (LS) simulation platform created for the Eaton NODES project. The simulation environment consists of both wholesale market simulator and distribution simulator and includes the CAISO wholesale market model and a PG&E footprint of 25-75 feeders to validate the scalability under a scenario of 33% RPS in California with additional 17% of DERS coming from distribution and customers. The simulator can generate hourly unit commitment, 5-minute economic dispatch, and 4-second AGC regulation signals. The simulator is also capable of simulating greater than 10k individual controllable devices. Simulated DERs include water heaters, EVs, residential and light commercial HVAC/buildings, and residential-level battery storage. Feeder-level voltage regulators and capacitor banks are also simulated for feeder-level real and reactive power management and Vol/Var control.

  19. Contribution of large scale coherence to wind turbine power: A large eddy simulation study in periodic wind farms

    Science.gov (United States)

    Chatterjee, Tanmoy; Peet, Yulia T.

    2018-03-01

    Length scales of eddies involved in the power generation of infinite wind farms are studied by analyzing the spectra of the turbulent flux of mean kinetic energy (MKE) from large eddy simulations (LES). Large-scale structures with an order of magnitude bigger than the turbine rotor diameter (D ) are shown to have substantial contribution to wind power. Varying dynamics in the intermediate scales (D -10 D ) are also observed from a parametric study involving interturbine distances and hub height of the turbines. Further insight about the eddies responsible for the power generation have been provided from the scaling analysis of two-dimensional premultiplied spectra of MKE flux. The LES code is developed in a high Reynolds number near-wall modeling framework, using an open-source spectral element code Nek5000, and the wind turbines have been modelled using a state-of-the-art actuator line model. The LES of infinite wind farms have been validated against the statistical results from the previous literature. The study is expected to improve our understanding of the complex multiscale dynamics in the domain of large wind farms and identify the length scales that contribute to the power. This information can be useful for design of wind farm layout and turbine placement that take advantage of the large-scale structures contributing to wind turbine power.

  20. Large Format CMOS-based Detectors for Diffraction Studies

    Science.gov (United States)

    Thompson, A. C.; Nix, J. C.; Achterkirchen, T. G.; Westbrook, E. M.

    2013-03-01

    Complementary Metal Oxide Semiconductor (CMOS) devices are rapidly replacing CCD devices in many commercial and medical applications. Recent developments in CMOS fabrication have improved their radiation hardness, device linearity, readout noise and thermal noise, making them suitable for x-ray crystallography detectors. Large-format (e.g. 10 cm × 15 cm) CMOS devices with a pixel size of 100 μm × 100 μm are now becoming available that can be butted together on three sides so that very large area detector can be made with no dead regions. Like CCD systems our CMOS systems use a GdOS:Tb scintillator plate to convert stopping x-rays into visible light which is then transferred with a fiber-optic plate to the sensitive surface of the CMOS sensor. The amount of light per x-ray on the sensor is much higher in the CMOS system than a CCD system because the fiber optic plate is only 3 mm thick while on a CCD system it is highly tapered and much longer. A CMOS sensor is an active pixel matrix such that every pixel is controlled and readout independently of all other pixels. This allows these devices to be readout while the sensor is collecting charge in all the other pixels. For x-ray diffraction detectors this is a major advantage since image frames can be collected continuously at up 20 Hz while the crystal is rotated. A complete diffraction dataset can be collected over five times faster than with CCD systems with lower radiation exposure to the crystal. In addition, since the data is taken fine-phi slice mode the 3D angular position of diffraction peaks is improved. We have developed a cooled 6 sensor CMOS detector with an active area of 28.2 × 29.5 cm with 100 μm × 100 μm pixels and a readout rate of 20 Hz. The detective quantum efficiency exceeds 60% over the range 8-12 keV. One, two and twelve sensor systems are also being developed for a variety of scientific applications. Since the sensors are butt able on three sides, even larger systems could be built at

  1. Large Format CMOS-based Detectors for Diffraction Studies

    International Nuclear Information System (INIS)

    Thompson, A C; Westbrook, E M; Nix, J C; Achterkirchen, T G

    2013-01-01

    Complementary Metal Oxide Semiconductor (CMOS) devices are rapidly replacing CCD devices in many commercial and medical applications. Recent developments in CMOS fabrication have improved their radiation hardness, device linearity, readout noise and thermal noise, making them suitable for x-ray crystallography detectors. Large-format (e.g. 10 cm × 15 cm) CMOS devices with a pixel size of 100 μm × 100 μm are now becoming available that can be butted together on three sides so that very large area detector can be made with no dead regions. Like CCD systems our CMOS systems use a GdOS:Tb scintillator plate to convert stopping x-rays into visible light which is then transferred with a fiber-optic plate to the sensitive surface of the CMOS sensor. The amount of light per x-ray on the sensor is much higher in the CMOS system than a CCD system because the fiber optic plate is only 3 mm thick while on a CCD system it is highly tapered and much longer. A CMOS sensor is an active pixel matrix such that every pixel is controlled and readout independently of all other pixels. This allows these devices to be readout while the sensor is collecting charge in all the other pixels. For x-ray diffraction detectors this is a major advantage since image frames can be collected continuously at up 20 Hz while the crystal is rotated. A complete diffraction dataset can be collected over five times faster than with CCD systems with lower radiation exposure to the crystal. In addition, since the data is taken fine-phi slice mode the 3D angular position of diffraction peaks is improved. We have developed a cooled 6 sensor CMOS detector with an active area of 28.2 × 29.5 cm with 100 μm × 100 μm pixels and a readout rate of 20 Hz. The detective quantum efficiency exceeds 60% over the range 8-12 keV. One, two and twelve sensor systems are also being developed for a variety of scientific applications. Since the sensors are butt able on three sides, even larger systems could be built at

  2. Study on water boiling noises in a large volume

    International Nuclear Information System (INIS)

    Masagutov, R.F.; Krivtsov, V.A.

    1977-01-01

    Presented are the results of measurement of the noise spectra during boiling of water in a large volume at the pressure of 1 at. Boiling of the distilled water has been accomplished with the use of the heaters made of the Kh18N10T steel, 50 mm in length, 2 mm in the outside diameter, with the wall thickness of 0.1 mm. The degree of water under heating changed during the experiments from 0 to 80 deg C, and the magnitude of the specific heat flux varied from o to 0.7 - 0.9 qsup(x), where qsup(x) was the specific heat flux of the tube burn-out. The noise spectrum of the boiling water was analyzed at frequencies of 0.5 to 200 kHz. The submerge-type pressure-electric transmitters were used for measurements. At underheating boiling during the experiment the standing waves have formed which determine the structure of the measured spectra. During saturated boiling of water no standing waves were revealed. At underheating over 15 - 20 deg C the water boiling process is accompanied by the noises within the ultrasonic frequency range. The maximum upper boundary of the noise in the experiments amounts to 90 - 100 kHz

  3. First electron-cloud studies at the Large Hadron Collider

    CERN Document Server

    Dominguez, O; Arduini, G; Metral, E; Rumolo, G; Zimmermann, F; Maury Cuna, H

    2013-01-01

    During the beam commissioning of the Large Hadron Collider (LHC) with 150, 75, 50, and 25-ns bunch spacing, important electron-cloud effects, like pressure rise, cryogenic heat load, beam instabilities, or emittance growth, were observed. Methods have been developed to infer different key beam-pipe surface parameters by benchmarking simulations and pressure rise as well as heat-load observations. These methods allow us to monitor the scrubbing process, i.e., the reduction of the secondary emission yield as a function of time, in order to decide on the most appropriate strategies for machine operation. To better understand the influence of electron clouds on the beam dynamics, simulations have been carried out to examine both the coherent and the incoherent effects on the beam. In this paper we present the methodology and first results for the scrubbing monitoring process at the LHC. We also review simulated instability thresholds and tune footprints for beams of different emittance, interacting with an electr...

  4. Study of Hydrokinetic Turbine Arrays with Large Eddy Simulation

    Science.gov (United States)

    Sale, Danny; Aliseda, Alberto

    2014-11-01

    Marine renewable energy is advancing towards commercialization, including electrical power generation from ocean, river, and tidal currents. The focus of this work is to develop numerical simulations capable of predicting the power generation potential of hydrokinetic turbine arrays-this includes analysis of unsteady and averaged flow fields, turbulence statistics, and unsteady loadings on turbine rotors and support structures due to interaction with rotor wakes and ambient turbulence. The governing equations of large-eddy-simulation (LES) are solved using a finite-volume method, and the presence of turbine blades are approximated by the actuator-line method in which hydrodynamic forces are projected to the flow field as a body force. The actuator-line approach captures helical wake formation including vortex shedding from individual blades, and the effects of drag and vorticity generation from the rough seabed surface are accounted for by wall-models. This LES framework was used to replicate a previous flume experiment consisting of three hydrokinetic turbines tested under various operating conditions and array layouts. Predictions of the power generation, velocity deficit and turbulence statistics in the wakes are compared between the LES and experimental datasets.

  5. International comparative studies of education and large scale change

    NARCIS (Netherlands)

    Howie, Sarah; Plomp, T.; Bascia, Nina; Cumming, Alister; Datnow, Amanda; Leithwood, Kenneth; Livingstone, David

    2005-01-01

    The development of international comparative studies of educational achievements dates back to the early 1960s and was made possible by developments in sample survey methodology, group testing techniques, test development, and data analysis (Husén & Tuijnman, 1994, p. 6). The studies involve

  6. Density limit studies in the large helical device

    International Nuclear Information System (INIS)

    Peterson, B.J.; Miyazawa, J.; Nishimura, K.

    2005-01-01

    Steady state densities of up to 1.6 x 10 20 m -3 have been sustained using gas puff fuelling and NBI heating up to 11 MW in the Large Helical Device (LHD). The density limit in LHD is observed to be ∼ 1.6 times the Sudo limit. The density is ultimately limited by radiative collapse which is attributed to the onset of a radiative thermal instability of the light impurities in the edge region of the plasma based on several observations. First of all the onset of the radiative thermal instability is tied to a certain edge temperature threshold. Secondly, the onset of thermal instability occurs first in oxygen and then carbon as expected from their cooling rate temperature dependencies. Finally, radiation profiles show that as the temperature drops and the plasma collapses the radiating zone broadens and moves inward. In addition, comparison with the total radiated power behaviour indicates that Carbon is the dominant radiator. Two dimensional tomographic inversions of AXUVD array data and comparison of modelling with images of radiation brightness from imaging bolometers and indicate that the poloidal asymmetry which accompanies the radiative collapse is toroidally symmetric. Ain addition to the operational density limit where the discharge is terminated by radiative collapse, a confinement limit has been recognized in LHD. This confinement limit appears at lower density than the operational density limit, similar to the saturated ohmic confinement observed in tokamaks. To investigate the physics behind this degradation, the parameter dependence of the thermal diffusivity, χ, has been investigated. While the temperature dependence in ISS95 is as strong as the gyro-Bohm model of χ ∝ T e 1.5 , weaker T e dependence of χ ∝ T e 0.5 appears in the high-density regime. Such weak T e dependence results in the weak density dependence of the global energy confinement as τ E ∝ n e 13 -bar. (author)

  7. Modeling connectivity to identify current and future anthropogenic barriers to movement of large carnivores: A case study in the American Southwest.

    Science.gov (United States)

    McClure, Meredith L; Dickson, Brett G; Nicholson, Kerry L

    2017-06-01

    This study sought to identify critical areas for puma ( Puma concolor ) movement across the state of Arizona in the American Southwest and to identify those most likely to be impacted by current and future human land uses, particularly expanding urban development and associated increases in traffic volume. Human populations in this region are expanding rapidly, with the potential for urban centers and busy roads to increasingly act as barriers to demographic and genetic connectivity of large-bodied, wide-ranging carnivores such as pumas, whose long-distance movements are likely to bring them into contact with human land uses and whose low tolerance both for and from humans may put them at risk unless opportunities for safe passage through or around human-modified landscapes are present. Brownian bridge movement models based on global positioning system collar data collected during bouts of active movement and linear mixed models were used to model habitat quality for puma movement; then, a wall-to-wall application of circuit theory models was used to produce a continuous statewide estimate of connectivity for puma movement and to identify pinch points, or bottlenecks, that may be most at risk of impacts from current and future traffic volume and expanding development. Rugged, shrub- and scrub-dominated regions were highlighted as those offering high quality movement habitat for pumas, and pinch points with the greatest potential impacts from expanding development and traffic, although widely distributed, were particularly prominent to the north and east of the city of Phoenix and along interstate highways in the western portion of the state. These pinch points likely constitute important conservation opportunities, where barriers to movement may cause disproportionate loss of connectivity, but also where actions such as placement of wildlife crossing structures or conservation easements could enhance connectivity and prevent detrimental impacts before they occur.

  8. State-wide performance criteria for international safeguards

    International Nuclear Information System (INIS)

    Budlong-Sylvester, K.W.; Pilat, Joseph F.; Stanbro, W.D.

    2001-01-01

    Traditionally, the International Atomic Energy Agency (IAEA) has relied upon prescriptive criteria to guide safeguards implementation. The prospect of replacing prescriptive safeguards criteria with more flexible performance criteria would constitute a structural change in safeguards and raises several important questions. Performance criteria imply that while safeguards goals will be fixed, the means of attaining those goals will not be explicitly prescribed. What would the performance objectives be under such a system? How would they be formulated? How would performance be linked to higher level safeguards objectives? How would safeguards performance be measured State-wide? The implementation of safeguards under performance criteria would also signal a dramatic change in the manner the Agency does business. A higher degree of flexibility could, in principle, produce greater effectiveness and efficiency, but would come with a need for increased Agency responsibility in practice. To the extent that reliance on prescriptive criteria decreases, the burden of justifying actions and ensuring their transparency will rise. Would there need to be limits to safeguards implementation? What would be the basis for setting such limits? This paper addresses these and other issues and questions relating to both the formulation and the implementation of performance-based criteria.

  9. Case study: improving efficiency in a large hospital laboratory.

    Science.gov (United States)

    Bartel, Marilynn

    2004-01-01

    Saint Francis Health System (SFHS) consists of three hospitals and one clinic: Saint Francis Hospital (SFH); Broken Arrow Medical Center; Laureate Psychiatric Hospital; and Warren Clinic. SFHS has 670 physicians on staff and serves medical (oncology, orthopedic, neurology, and renal), surgical, cardiac, women and infant, pediatric, transplant, and trauma patients in Tulsa County, Oklahoma, which has a population of 660,000. SFH incorporates 706 staffed beds, including 126 pediatric beds and 119 critical care beds. Each year, the health system averages 38,000 admissions, 70,000 emergency department visits, 25,000 surgeries, and 3,500 births. Saint Francis Laboratory is located within the main hospital facility (SFH) and functions as a core lab for the health system. The lab also coordinates lab services with Saint Francis Heart Hospital, a physician-system joint venture. The Optimal Equipment Configuration (OEC) Project was designed by the Clinical Laboratory Services division of Premier, a group purchasing organization, with the goal of determining whether laboratories could improve efficiency and decrease unit cost by using a single-source vendor. Participants included seven business partners (Abbott, Bayer, Beckman/Coulter, Dade/Behring, J&J/ Ortho, Olympus, and Roche) and 21 laboratory sites (a small, mid-sized, and large site for each vendor). SFH laboratory staff embraced Premier's concept and viewed the OEC project as an opportunity to "energize" laboratory operations. SFH partnered with Abbott, their primary equipment vendor, for the project. Using resources and tools made available through the project, the laboratory was re-engineered to simplify workflow, increase productivity, and decrease costs by adding automation and changing to centralized specimen processing. Abbott and SFH shared a common vision for the project and enhanced their partnership through increased communication and problem solving. Abbott's area representatives provided for third

  10. Large General Purpose Frame for Studying Force Vectors

    Science.gov (United States)

    Heid, Christy; Rampolla, Donald

    2011-01-01

    Many illustrations and problems on the vector nature of forces have weights and forces in a vertical plane. One of the common devices for studying the vector nature of forces is a horizontal "force table," in which forces are produced by weights hanging vertically and transmitted to cords in a horizontal plane. Because some students have…

  11. Architecture Alignment in a Large Government Organization: A Case Study

    NARCIS (Netherlands)

    Wieringa, Roelf J.; van Eck, Pascal; Blanken, Henk; Grabis, J.; Persson, A.; Stirna, J.

    In this paper we view IT architecture as the structures presentin the entire information technology support used by an organization. We report on a detailed case study of an operational IT architecture process, in which we investigated the relationship between IT architecture and business context.We

  12. Harvesting Collective Trend Observations from Large Scale Study Trips

    DEFF Research Database (Denmark)

    Eriksen, Kaare; Ovesen, Nis

    2014-01-01

    To enhance industrial design students’ decoding and understanding of the technological possibilities and the diversity of needs and preferences in different cultures it is not unusual to arrange study trips where such students acquire a broader view to strengthen their professional skills and app...... numbers of students to the annual Milan Design Week and the Milan fair ‘I Saloni’ in Italy. The present paper describes and evaluates the method, the theory behind it, the practical execution of the trend registration, the results from the activities and future perspectives....... and approach, hence linking the design education and the design culture of the surrounding world. To improve the professional learning it is useful, though, to facilitate and organize the trips in a way that involves systematic data collection and reporting. This paper presents a method for facilitating study...

  13. CONTINUOUS IMPROVEMENT PRACTICE IN LARGE ENTERPRISES: STUDY RESULTS

    Directory of Open Access Journals (Sweden)

    Dorota Stadnicka

    2015-03-01

    Full Text Available Continuous improvement is indispensable for ensuring the company's development and its survival on the constantly changing global market. Continuous improvement is particularly important in the quality and production management systems. A company should deliver a product compliant with a client's requirements in a specified time and at an appropriate price. That is why, continuous improvement refers to different areas of an organization's functioning and it is an integral part of Lean Manufacturing. This article presents the results of the study conducted in production enterprises on a limited area. The aim of the study was the assessment of the implementation of continuous improvement in Lean Manufacturing, and, in particular, employees' involvement in the problem identification and in reporting improvements as well as the way of motivating employees to involve themselves. The authors also tried to identify the factors influencing the elements of a continuous improvement system.

  14. Study of large nonlinear change phase in Hibiscus Sabdariffa

    Science.gov (United States)

    Trejo-Durán, M.; Alvarado-Méndez, E.; Andrade-Lucio, J. A.; Rojas-Laguna, R.; Vázquez-Guevara, M. A.

    2015-09-01

    High intensities electromagnetic energy interacting with organic media gives rise to nonlinear optical effects. Hibiscus Sabdariffa is a flower whose concentrated solution presents interesting nonlinear optical properties. This organic material shows an important self-phase modulation with changes bigger than 2π. We present a diffraction ring patterns study of the Hibiscus Sabdariffa solution. Numerical results of transmittance, with refraction and simultaneous absorption, are shown.

  15. Photoinduced surface voltage mapping study for large perovskite single crystals

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Xiaojing; Liu, Yucheng; Gao, Fei; Yang, Zhou [Key Laboratory of Applied Surface and Colloid Chemistry, National Ministry of Education, Shaanxi Engineering Laboratory for Advanced Energy Technology, School of Materials Science and Engineering, Shaanxi Normal University, Xi' an 710062 (China); Liu, Shengzhong, E-mail: liusz@snnu.edu.cn [Key Laboratory of Applied Surface and Colloid Chemistry, National Ministry of Education, Shaanxi Engineering Laboratory for Advanced Energy Technology, School of Materials Science and Engineering, Shaanxi Normal University, Xi' an 710062 (China); Dalian Institute of Chemical Physics, iChEM, Dalian National Laboratory for Clean Energy, Chinese Academy of Sciences, Dalian 116023 (China)

    2016-05-02

    Using a series of illumination sources, including white light (tungsten-halogen lamp), 445-nm, 532-nm, 635-nm, and 730-nm lasers, the surface photovoltage (SPV) images were mapped for centimeter-sized CH{sub 3}NH{sub 3}PbX{sub 3} (X = Cl, Br, I) perovskite single crystals using Kelvin probe force microscopy. The significant SPV signals were observed to be wavelength-dependent. We attribute the appreciable SPV to the built-in electric field in the space charge region. This study shines light into the understanding of photoinduced charge generation and separation processes at nanoscale to help advance the development of perovskite solar cells, optoelectronics, laser, photodetector, and light-emitting diode (LED).

  16. Michigan Pharmacists Transforming Care and Quality: Developing a Statewide Collaborative of Physician Organizations and Pharmacists to Improve Quality of Care and Reduce Costs.

    Science.gov (United States)

    Choe, Hae Mi; Lin, Alexandra Tungol; Kobernik, Kathleen; Cohen, Marc; Wesolowicz, Laurie; Qureshi, Nabeel; Leyden, Tom; Share, David A; Darland, Rozanne; Spahlinger, David A

    2018-04-01

    site. MPTCQ is a unique collaboration between a large academic institution, physician organizations, a payer, and a statewide coordinating center to improve patient care and address medication-related challenges by integrating pharmacists into a PCMH network. Pharmacists can actively provide their medication expertise to physicians and patients and optimize quality measure performance. This project was funded by Blue Cross Blue Shield of Michigan. Choe and Spahlinger are employees of Michigan Medicine. Tungol Lin, Kobernik, Cohen, Qureshi, Leyden, and Darland are employees of Blue Cross Blue Shield of Michigan. At the time of manuscript preparation, Share and Wesolowicz were employees of Blue Cross Blue Shield of Michigan. Study concept and design were primarily contributed by Choe, along with the other authors. Choe, Tungol Lin, and Kobernik collected data, and data interpretation was performed by Choe, Tungol Lin, Cohen, and Wesolowicz. The manuscript was written primarily by Choe, along with Tungol Lin and assisted by Kobernik, Cohen, Leyden, and Qureshi. The manuscript was revised by Leyden, Spahlinger, Share, and Darland. Material from this manuscript was previously presented as an education session at the 2016 AMCP Managed Care & Specialty Pharmacy Annual Meeting; April 19-22, 2016; San Francisco, California.

  17. Construction and performance studies of large resistive Micromegas quadruplets

    CERN Document Server

    AUTHOR|(INSPIRE)INSPIRE-00508881; Iengo, Paolo; Bianco, Michele; Sidiropoulou, Ourania; Kuger, Fabian; Sekhniaidze, Givi; Wotschack, Jorg; Vergain, Maurice; Danielsson, Hans Olof; Degrange, Jordan; Schott, Matthias; Lin, Tai-Hua; Valderanis, Chrysostomos; Dudder, Andreas Christian

    2015-01-01

    In view of the use of Micromegas detectors for the upgrade of the ATLAS muon system, two detector quadruplets with an area of 0.3 m$^2$ per plane serving as prototypes for future ATLAS chambers have been constructed. They are based on the resistive-strip technology and thus spark tolerant. The detectors were built in a modular way. The quadruplets consist of two double-sided readout panels and three support (or drift) panels equipped with the micromesh and the drift electrode. The panels are bolted together such that the detector can be opened and cleaned, if required. Two of the readout planes are equipped with readout strips inclined by 1.5 degree. In this talk, we present the results of detailed performance studies based on X-Ray and cosmic ray measurements as well as measurements with 855 MeV electrons at the MAMI accelerator. In particular, results on reconstruction efficiencies, track resolution and gain homogeneity is presented.

  18. Construction and Performance Studies of Large Resistive Micromegas Quadruplets

    CERN Document Server

    Farina, Edoardo Maria; The ATLAS collaboration; Kuger, Fabian; Sidiropoulou, Ourania; Iengo, Paolo; Sekhniaidze, Givi; Wotschack, Jorg; Lin, Tai-Hua; Schott, Matthias; Valderanis, Chrysostomos; Dudder, Andreas Christian

    2015-01-01

    In view of the use of micromegas detectors for the upgrade of the ATLAS muon system, two detector quadruplets with an area of 0.5 m2 per plane serving as prototypes for future ATLAS chambers have been constructed. They are based on the resistive-strip technology and thus spark tolerant. The detectors were built in a modular way. The quadruplets consist of two double-sided readout panels and three support (or drift) panels equipped with the micromesh and the drift electrode. The panels are bolted together such that the detector can be opened and cleaned, if required. Two of the readout planes are equipped with readout strips inclined by 1.5 degree. In this talk, we present the results of detailed performance studies based on X-Ray measurements, cosmic ray- and test-beam measurements at the MAMI accelerator that have been conducted in the past months. In particular, results on reconstruction efficiencies, track resolution and gain homogeneity will be presented.

  19. Construction and Performance Studies of Large Resistive Micromegas Quadruplets

    Science.gov (United States)

    Farina, E.; Iengo, P.; Bianco, M.; Sidiropoulou, O.; Kuger, F.; Sekhniaidze, G.; Vergain, M.; Wotschack, J.; Danielsson, H.; Degrange, J.; De Oliveira, R.; Schott, M.; Lin, Tai-Hua; Valderanis, C.; Düdder, A.

    2018-02-01

    In view of the use of Micromegas detectors for the upgrade of the ATLAS muon system, two detector quadruplets with an area of 0.3 m2 per plane serving as prototypes for future ATLAS chambers have been constructed. They are based on the resistive-strip technology and thus spark tolerant. The detectors were built in a modular way. The quadruplets consist of two double-sided readout panels and three support (or drift) panels equipped with the micromesh and the drift electrode. The panels are bolted together such that the detector can be opened and cleaned, if required. Two of the readout planes are equipped with readout strips inclined by 1.5 degree. In this talk, we present the results of detailed performance studies based on X-Ray and cosmic ray measurements as well as measurements with 855 MeV electrons at the MAMI accelerator. In particular, results on reconstruction efficiencies, track resolution and gain homogeneity is presented.

  20. Large eddy simulation study of the kinetic energy entrainment by energetic turbulent flow structures in large wind farms

    Science.gov (United States)

    VerHulst, Claire; Meneveau, Charles

    2014-02-01

    In this study, we address the question of how kinetic energy is entrained into large wind turbine arrays and, in particular, how large-scale flow structures contribute to such entrainment. Previous research has shown this entrainment to be an important limiting factor in the performance of very large arrays where the flow becomes fully developed and there is a balance between the forcing of the atmospheric boundary layer and the resistance of the wind turbines. Given the high Reynolds numbers and domain sizes on the order of kilometers, we rely on wall-modeled large eddy simulation (LES) to simulate turbulent flow within the wind farm. Three-dimensional proper orthogonal decomposition (POD) analysis is then used to identify the most energetic flow structures present in the LES data. We quantify the contribution of each POD mode to the kinetic energy entrainment and its dependence on the layout of the wind turbine array. The primary large-scale structures are found to be streamwise, counter-rotating vortices located above the height of the wind turbines. While the flow is periodic, the geometry is not invariant to all horizontal translations due to the presence of the wind turbines and thus POD modes need not be Fourier modes. Differences of the obtained modes with Fourier modes are documented. Some of the modes are responsible for a large fraction of the kinetic energy flux to the wind turbine region. Surprisingly, more flow structures (POD modes) are needed to capture at least 40% of the turbulent kinetic energy, for which the POD analysis is optimal, than are needed to capture at least 40% of the kinetic energy flux to the turbines. For comparison, we consider the cases of aligned and staggered wind turbine arrays in a neutral atmospheric boundary layer as well as a reference case without wind turbines. While the general characteristics of the flow structures are robust, the net kinetic energy entrainment to the turbines depends on the presence and relative

  1. Achieving online consent to participation in large-scale gene-environment studies: a tangible destination

    NARCIS (Netherlands)

    Wood, F.; Kowalczuk, J.; Elwyn, G.; Mitchell, C.; Gallacher, J.

    2011-01-01

    BACKGROUND: Population based genetics studies are dependent on large numbers of individuals in the pursuit of small effect sizes. Recruiting and consenting a large number of participants is both costly and time consuming. We explored whether an online consent process for large-scale genetics studies

  2. Tactical emergency medical support programs: a comprehensive statewide survey.

    Science.gov (United States)

    Bozeman, William P; Morel, Benjamin M; Black, Timothy D; Winslow, James E

    2012-01-01

    Specially trained tactical emergency medical support (TEMS) personnel provide support to law enforcement special weapons and tactics (SWAT) teams. These programs benefit law enforcement agencies, officers, suspects, and citizens. TEMS programs are increasingly popular, but there are wide variations in their organization and operation and no recent data on their prevalence. We sought to measure the current prevalence and specific characteristics of TEMS programs in a comprehensive fashion in a single southeastern state. North Carolina emergency medical services (EMS) systems have county-based central EMS oversight; each system was surveyed by phone and e-mail. The presence and selected characteristics of TEMS programs were recorded. U.S. Census data were used to measure the population impact of the programs. All of the 101 EMS systems statewide were successfully contacted. Thirty-three counties (33%) have TEMS programs providing medical support to 56 local law enforcement agencies as well as state and federal agencies. TEMS programs tend to be located in more populated urban and suburban areas, serving a population base of 5.9 million people, or 64% of the state's population. Tactical medics in the majority of these programs (29/33; 88%) are not sworn law enforcement officers. Approximately one-third of county-based EMS systems in North Carolina have TEMS programs. These programs serve almost two-thirds of the state's population base, using primarily nonsworn tactical medics. Comparison with other regions of the country will be useful to demonstrate differences in prevalence and program characteristics. Serial surveillance will help track trends and measure the growth and impact of this growing subspecialty field.

  3. Development of statewide geriatric patients trauma triage criteria.

    Science.gov (United States)

    Werman, Howard A; Erskine, Timothy; Caterino, Jeffrey; Riebe, Jane F; Valasek, Tricia

    2011-06-01

    The geriatric population is unique in the type of traumatic injuries sustained, physiological responses to those injuries, and an overall higher mortality when compared to younger adults. No published, evidence-based, geriatric-specific field destination criteria exist as part of a statewide trauma system. The Trauma Committee of the Ohio Emergency Medical Services (EMS) Board sought to develop specific criteria for geriatric trauma victims. A literature search was conducted for all relevant literature to determine potential, geriatric-specific, field-destination criteria. Data from the Ohio Trauma Registry were used to compare elderly patients, defined as age >70 years, to all patients between the ages of 16 to 69 years with regards to mortality risk in the following areas: (1) Glasgow Coma Scale (GCS) score; (2) systolic blood pressure (SBP); (3) falls associated with head, chest, abdominal or spinal injury; (4) mechanism of injury; (5) involvement of more than one body system as defined in the Barell matrix; and (6) co-morbidities and motor vehicle collision with one or more long bone fracture. For GCS score and SBP, those cut-off points with equal or greater risk of mortality as compared to current values were chosen as proposed triage criteria. For other measures, any criterion demonstrating a statistically significant increase in mortality risk was included in the proposed criteria. The following criteria were identified as geriatric-specific criteria: (1) GCS score trauma; (2) SBP trauma. In addition, these data suggested that elderly patients with specific co-morbidities be given strong consideration for evaluation in a trauma center. The state of Ohio is the first state to develop evidence-based geriatric-specific field-destination criteria using data from its state-mandated trauma registry. Further analysis of these criteria will help determine their effects on over-triage and under-triage of geriatric victims of traumatic injuries and the impact on the

  4. Successful long-term maintenance following Nutrition Care Process Terminology implementation across a state-wide health-care system.

    Science.gov (United States)

    Vivanti, Angela; O'Sullivan, Therese A; Porter, Jane; Hogg, Marion

    2017-09-01

    Three years following a state-wide Nutrition Care Process Terminology (NCPT) implementation project, the present study aimed to (i) assess changes in NCPT knowledge and attitudes, (ii) identify implementation barriers and enablers and (iii) seek managers' opinions post-implementation. Pre-implementation and three years post-implementation, all Queensland Government hospitals state-wide were invited to repeat a validated NCPT survey. Additionally, a separate survey sought dietetic managers' opinions regarding NCPT's use and acceptance, usefulness for patient care, role in service planning and continued use. A total of 238 dietitians completed the survey in 2011 and 82 dietitians in 2014. Use of diagnostic statement in the previous six months improved (P  0.05). Key elements in sustaining NCPT implementation over three years included ongoing management support, workshops/tutorials, discussion and mentor and peer support. The most valued resources were pocket guides, ongoing workshops/tutorials and mentor support. Dietetic managers held many positive NCPT views, however, opinions differed around the usefulness of service planning, safer practice, improving patient care and facilitating communication. Some managers would not support NCPT unless it was recommended for practice. Immediate improvements following the NCPT implementation project were sustained over three years. Moving forward, a professional focus on continuing to incorporate NCPT into standard practice will provide structure for process and outcomes assessment. © 2017 State of Queensland. Nutrition and Dietetics © 2017 Dietitians Association of Australia.

  5. National Mandates and Statewide Enactments: Inquiry in/to Large-Scale Reform

    Science.gov (United States)

    Hines, Mary Beth; Conner, Jenny; Campano, Gerald; Damico, James; Enoch, Melissa; Nam, Daehyeon

    2007-01-01

    Since the inauguration of the No Child Left Behind Act of 2001 (NCLB) in the United States, with a billion-dollar budget to induce educational reform, American schools have been under the microscope for meeting accountability standards for students. The performance pressures have intensified as the consequences for not achieving academic…

  6. Statewide dissemination of a rural, non-chain restaurant intervention: adoption, implementation and maintenance

    Science.gov (United States)

    Nothwehr, F.; Haines, H.; Chrisman, M.; Schultz, U.

    2014-01-01

    The obesity epidemic calls for greater dissemination of nutrition-related programs, yet there remain few studies of the dissemination process. This study, guided by elements of the RE-AIM model, describes the statewide dissemination of a simple, point-of-purchase restaurant intervention. Conducted in rural counties of the Midwest, United States, the study targeted randomly selected, non-chain, family-style restaurants. Owners were recruited through mail, then telephone follow-up. Data were collected through telephone at baseline, and 3, 6, 12 and 18 months post-adoption. Using mixed methods, measures captured the program adoption rate, characteristics of adopters and non-adopters, program implementation and maintenance issues, and owner and customer satisfaction. Analyses involved descriptive statistics and summaries of qualitative data. The program adoption rate was 28%. Adopters were similar to responding non-adopters demographically, but varied in attitudes. The majority of restaurants maintained the program for at least 12 months. Adopters and their customers expressed satisfaction with the program. With some adjustments, the RE-AIM model was helpful in guiding evaluation of this process. Results provide implications for future dissemination of this and other programs with regard to research procedures and potential barriers that may be encountered. Research on alternative strategies for widespread dissemination of such programs is needed in this and other settings. PMID:24650944

  7. Analyzing the Measurement Equivalence of a Translated Test in a Statewide Assessment Program

    Directory of Open Access Journals (Sweden)

    Jorge Carvajal-Espinoza

    2016-09-01

    Full Text Available When tests are translated into one or more languages, the question of the equivalence of items across language forms arises. This equivalence can be assessed at the scale level by means of a multiple group confirmatory factor analysis (CFA in the context of structural equation modeling. This study examined the measurement equivalence of a Spanish translated version of a statewide Mathematics test originally constructed in English by using a multi-group CFA approach. The study used samples of native speakers of the target language of the translation taking the test in both the source and target language, specifically Hispanics taking the test in English and Spanish. Test items were grouped in twelve facet-representative parcels. The parceling was accomplished by grouping items that corresponded to similar content and computing an average for each parcel. Four models were fitted to examine the equivalence of the test across groups. The multi-group CFA fixed factor loadings across groups and results supported the equivalence of the two language versions (English and Spanish of the test. The statistical techniques implemented in this study can also be used to address the performance on a test based on dichotomous or dichotomized variables such as gender, socioeconomic status, geographic location and other variables of interest.

  8. A California Statewide App to Simulate Fate of Nitrate in Irrigated Agricultural System

    Science.gov (United States)

    Diamantopoulos, E.; Walkinshaw, M.; Harter, T.; O'Geen, A. T.

    2017-12-01

    Groundwater resources are very important for California's economic development and environmental sustainability. Nitrate is by far the most widespread anthropogenic groundwater pollutant in California's mostly alluvial groundwater basins. Major sources are synthetic fertilizer and dairy manure, but also septic systems and urban wastewater effluent. Here, we evaluate agricultural soils in California according to their risk for nitrate leaching. We conducted over 1 million numerical simulations taking into account the effect of climate, crop type, irrigation and fertilization management scenarios across all 4,568 agricultural soil profiles occurring in California. The assessment was done solving 1-D Richards equation and the advection-dispersion equation numerically. This study is focused on the complex water and nitrate dynamics occurring at the shallow vadose zone (rootzone). The results of this study allow the construction of state-wide maps which can be used for the identification of high-risk regions and the design of agricultural nutrient management policy. We investigate how pollution risk can be minimized by adopting simple irrigation and fertilization methods. Furthermore, we show that these methods are more effective for the most permeable soil profiles along with high demanding crops in terms of fertilization amount and irrigation water. We also present how seasonal (winter) climate conditions contribute on nitrate leaching.

  9. The Critical Role of a Well-Articulated, Coherent Design in Professional Development: An Evaluation of a State-Wide Two-Week Program for Mathematics and Science Teachers

    Science.gov (United States)

    Saderholm, Jon; Ronau, Robert N.; Rakes, Christopher R.; Bush, Sarah B.; Mohr-Schroeder, Margaret

    2017-01-01

    This evaluation study examined a state-wide professional development program composed of two institutes, one for mathematics teachers and one for science teachers, each spanning two weeks. The program was designed to help teachers transform their practice to align with Common Core State Standards for Mathematics and Next Generation Science…

  10. Empowering High School Students in Scientific Careers: Developing Statewide Partnerships

    Science.gov (United States)

    Aguilar, C.; Swartz, D.

    2008-05-01

    Center for Multiscale Modeling of Atmospheric Processes (CMMAP) is a National Science Foundation Science and Technology Center focused on improving the representation of cloud processes in climate models. The Center is divided into three sections including Knowledge Transfer, Research, and Education and Diversity. The Science Education and Diversity mission is to educate and train people with diverse backgrounds in Climate and Earth System Science by enhancing teaching and learning and disseminating science results through multiple media. CMMAP is partnering with two local school districts to host an annual global climate conferences for high school students. The 2008 Colorado Global Climate Conference seeks "To educate students on global and local climate issues and empower them to se their knowledge." The conference is sponsored by CMMAP, The Governor's Energy Office, Poudre School District, Thompson School District, Clif Bar, and Ben and Jerry's Scoop Shop of Fort Collins. The conference seeks to inspire students to pursue future education and careers in science fields. Following an opening welcome from the Governor's Energy Office, Keynote Piers Sellers will discuss his experiences as an atmospheric scientist and NASA astronaut. Students will then attend 3 out of 16 breakout sessions including such sessions as "Hot poems, Cool Paintings, and the treasures of Antiquity of Climate Change", "Mitigation vs Adaptation", "Bigfoot Walks(What Size is our carbon footprint?)" "The Wedges: Reduc ing Carbon Emissions", and "We the People: Climate and Culture of Climate Change" to name a few. Using The Governor's High School Conference on the Environment sponsored by the Wisconsin Center for Environmental Education as a model we are developing statewide partnerships to bring high school students together to look at global climate issues that will impact their future and of which they can be part of the solution through their education and career paths. In addition to

  11. FINAL TECHNICAL REPORT FOR FORESTRY BIOFUEL STATEWIDE COLLABORATION CENTER (MICHIGAN)

    Energy Technology Data Exchange (ETDEWEB)

    LaCourt, Donna M.; Miller, Raymond O.; Shonnard, David R.

    2012-04-24

    A team composed of scientists from Michigan State University (MSU) and Michigan Technological University (MTU) assembled to better understand, document, and improve systems for using forest-based biomass feedstocks in the production of energy products within Michigan. Work was funded by a grant (DE-EE-0000280) from the U.S. Department of Energy (DOE) and was administered by the Michigan Economic Development Corporation (MEDC). The goal of the project was to improve the forest feedstock supply infrastructure to sustainably provide woody biomass for biofuel production in Michigan over the long-term. Work was divided into four broad areas with associated objectives: • TASK A: Develop a Forest-Based Biomass Assessment for Michigan – Define forest-based feedstock inventory, availability, and the potential of forest-based feedstock to support state and federal renewable energy goals while maintaining current uses. • TASK B: Improve Harvesting, Processing and Transportation Systems – Identify and develop cost, energy, and carbon efficient harvesting, processing and transportation systems. • TASK C: Improve Forest Feedstock Productivity and Sustainability – Identify and develop sustainable feedstock production systems through the establishment and monitoring of a statewide network of field trials in forests and energy plantations. • TASK D: Engage Stakeholders – Increase understanding of forest biomass production systems for biofuels by a broad range of stakeholders. The goal and objectives of this research and development project were fulfilled with key model deliverables including: 1) The Forest Biomass Inventory System (Sub-task A1) of feedstock inventory and availability and, 2) The Supply Chain Model (Sub-task B2). Both models are vital to Michigan’s forest biomass industry and support forecasting delivered cost, as well as carbon and energy balance. All of these elements are important to facilitate investor, operational and policy decisions. All

  12. Outcomes of a statewide anti-tobacco industry youth organizing movement.

    Science.gov (United States)

    Dunn, Caroline L; Pirie, Phyllis L; Oakes, J Michael

    2004-01-01

    To outline the design and present select findings from an evaluation of a statewide anti-tobacco industry youth organizing movement. A telephone survey was administered to teenagers to assess associations between exposure to anti-industry youth organizing activities and tobacco-related attitudes and behaviors. A group-level comparison between areas high and low in youth organizing activities was planned. Methodological obstacles necessitated a subject-level analytic approach, with comparisons being made between youth at higher and lower levels of exposure. Six rural areas (comprising 13 counties) and two urban regions of Minnesota were selected for survey. The study comprised 852 youth, aged 15 to 17 years old, randomly selected from county-specific sampling frames constructed from a marketing research database. Exposure index scores were developed for two types of activities designed to involve youth in the anti-industry program: branding (creating awareness of the movement in general) and messaging (informing about the movement's main messages). Attitudinal outcomes measured attitudes about the tobacco industry and the effectiveness of youth action. Behavioral outcomes included taking action to get involved in the organization, spreading an anti-industry message, and smoking susceptibility. Branding index scores were significantly correlated with taking action to get involved (p strategy for involving youth in tobacco prevention and generating negative attitudes about the industry.

  13. A Multilevel, Statewide Investigation of School District Anti-Bullying Policy Quality and Student Bullying Involvement.

    Science.gov (United States)

    Gower, Amy L; Cousin, Molly; Borowsky, Iris W

    2017-03-01

    Although nearly all states in the United States require school districts to adopt anti-bullying policies, little research examines the effect of these policies on student bullying and health. Using a statewide sample, we investigated associations between the quality of school district anti-bullying policies and student bullying involvement and adjustment. School district anti-bullying policies (N = 208) were coded for their quality based on established criteria. District-level data were combined with student reports of bullying involvement, emotional distress, and school connectedness from a state surveillance survey of 6th, 9th, and 12th grade students (N = 93,437). Results indicated that policy quality was positively related to bullying victimization. Furthermore, students reporting frequent perpetration/victimization who also attended districts with high-quality policies reported more emotional distress and less school connectedness compared with students attending districts with low quality policies. Although statistically significant, the magnitude of these associations was small. Having a high-quality school district anti-bullying policy is not sufficient to reduce bullying and protect bullying-involved young people. Future studies examining policy implementation will inform best practices in bullying prevention. © 2017, American School Health Association.

  14. Emergency Department Visits Prior to Suicide and Homicide: Linking Statewide Surveillance Systems.

    Science.gov (United States)

    Cerel, Julie; Singleton, Michael D; Brown, Margaret M; Brown, Sabrina V; Bush, Heather M; Brancado, Candice J

    2016-01-01

    Emergency departments (EDs) serve a wide range of patients who present at risk of impending suicide and homicide. Two statewide surveillance systems were probabilistically linked to understand who utilizes EDs and then dies violently within 6 weeks. Each identified case was matched with four randomly selected controls on sex, race, date of birth, resident zip code, and date of ED visit vs. date of death. Matched-pair odds ratios were estimated by conditional logistic regression to assess differences between cases and controls on reported diagnoses and expected payment sources. Of 1,599 suicides and 569 homicides in the 3-year study period, 10.7% of decedents who died by suicide (mean = 13.6 days) and 8.3% who died by homicide (mean = 16.3 days) were seen in a state ED within 6 weeks prior to death. ED attendees who died by suicide were more likely to have a diagnosis of injury/ poisoning diagnosis or mental disorder and more likely to have Medicare. Those who died by homicide were more likely to have a diagnosis of injury/poisoning and less likely to have commercial insurance. It is essential for research to further explore risk factors for imminent suicide and homicide in ED patients who present for psychiatric conditions and general injuries.

  15. Large discrepancies observed in theoretical studies of ion-impact ionization of the atomic targets at large momentum transfer

    Science.gov (United States)

    Ghorbani, Omid; Ghanbari-Adivi, Ebrahim

    2017-12-01

    A full quantum mechanical version of the three-body distorted wave-eikonal initial state (3DW-EIS) theory is developed to study of the single ionization of the atomic targets by ion impact at different momentum transfers. The calculations are performed both with and without including the internuclear interaction in the transition amplitude. For 16 \\text{Mev} \\text{O}7+ \\text{-He}~(1s2 ) and 24 \\text{Mev} \\text{O}8+\\text{-Li}~(2s ) collisions, the emission of the active electron into the scattering plane is considered and the fully differential cross-sections (FDCSs) are calculated for a fixed value of the ejected electron energy and a variety of momentum transfers. For both the specified collision systems, the obtained results are compared with the experimental data and with the cross-sections obtained using the semi-classical continuum distorted wave-eikonal initial state (CDW-EIS) approach. For 16 \\text{Mev} \\text{O}7+ \\text{-He}~(1s^2) , we also compared the results with those of a four-body three-Coulomb-wave (3CW) model. In general, we find some large discrepancies between the results obtained by different theories. These discrepancies are much more significant at larger momentum transfers. Also, for some ranges of the electron emission angles the results are much more sensitive to the internuclear interaction to be either turned on or off.

  16. 2011-2013 Indiana Statewide Imagery and LiDAR Program: Lake Michigan Watershed Counties

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Indiana's Statewide LiDAR data is produced at 1.5-meter average post spacing for all 92 Indiana Counties covering more than 36,420 square miles. New LiDAR data was...

  17. Criminal Justice Profile--Statewide, 1984. Supplement to "Crime and Delinquency in California."

    Science.gov (United States)

    California State Dept. of Justice, Sacramento. Bureau of Criminal Statistics and Special Services.

    This California annual Criminal Justice Statewide Profile presents data which supplements the Bureau of Criminal Statistics' (BCS) annual Crime and Delinquency publication. This monograph summarizes and combines data pertaining to California's justice system. The profile consists of two sections. The first section consists of 12 tables displaying…

  18. Taking Stock of Private-School Choice: Scholars Review the Research on Statewide Programs

    Science.gov (United States)

    Wolf, Patrick J.; Harris, Douglas N.; Berends, Mark; Waddington, R. Joseph; Austin, Megan

    2018-01-01

    In the past few years, four states have established programs that provide public financial support to students who choose to attend a private school. These programs--a tax-credit-funded scholarship initiative in Florida and voucher programs in Indiana, Louisiana, and Ohio--offer a glimpse of what expansive statewide choice might look like. What…

  19. Hawai'i Youth at Risk? Conceptual Challenges in Communicating a Statewide Mentoring Initiative.

    Science.gov (United States)

    Pollard, Vincent Kelly

    This paper discusses several issues considered as part of a statewide mentoring initiative. It is divided into three sections. The first section summarizes the key issues associated with short-term mentoring and mentoring in a longer-term, socially transformative context. Data from Comprehensive School Alienation Program is discussed concerning…

  20. Road Map to Statewide Implementation of the Pyramid Model. Roadmap to Effective Intervention Practices #6

    Science.gov (United States)

    Dunlap, Glen; Smith, Barbara J.; Fox, Lise; Blase, Karen

    2014-01-01

    This document is a guide--a "Road Map"--for implementing widespread use of the Pyramid Model for Promoting Social Emotional Competence in Infants and Young Children (http://www.challengingbehavior.org/do/pyramid_model. htm). It is a road map of systems change. The Road Map is written for statewide systems change, although it could be…

  1. Statewide improvement approach to clinician burnout: Findings from the baseline year

    Directory of Open Access Journals (Sweden)

    Heather R. Britt

    2017-12-01

    We propose a socio-ecological framework for acting on burnout, using a data-driven quality improvement paradigm enabled by a statewide coalition, to ensure that continued efforts do not rest solely at the feet of individuals or systems. Despite high burnout levels, engagement and satisfaction with work are also high, suggesting there is still hope for stemming the tide of burnout.

  2. A Multilevel, Statewide Investigation of School District Anti-Bullying Policy Quality and Student Bullying Involvement

    Science.gov (United States)

    Gower, Amy L.; Cousin, Molly; Borowsky, Iris W.

    2017-01-01

    Background: Although nearly all states in the United States require school districts to adopt anti-bullying policies, little research examines the effect of these policies on student bullying and health. Using a statewide sample, we investigated associations between the quality of school district anti-bullying policies and student bullying…

  3. Making an Impact Statewide to Benefit 21st-Century School Leadership

    Science.gov (United States)

    Hewitt, Kimberly Kappler; Mullen, Carol A.; Davis, Ann W.; Lashley, Carl

    2012-01-01

    How can institutions of higher education, local education agencies, and departments of education partner to build capacity for 21st-Century school leadership? The model (IMPACT V) we describe utilizes a systems-wide partnership approach to cultivate shared leadership within influenced middle and high schools statewide to leverage technology as a…

  4. From Theory to Practice: Considerations for Implementing a Statewide Voucher System.

    Science.gov (United States)

    Doyle, Denis P.

    This monograph analyzes trends in American educational philosophy and history in its proposal to implement an all-public statewide school voucher system. Following an introduction, section 1, "Alternative Voucher Systems," discusses three concepts: universal unregulated vouchers, favored by Milton Friedman; regulated compensatory vouchers,…

  5. Predictors of Suicidal Ideation in a Statewide Sample of Transgender Individuals

    OpenAIRE

    Rood, Brian A.; Puckett, Julia A.; Pantalone, David W.; Bradford, Judith B.

    2015-01-01

    Transgender individuals experience violence and discrimination, which, in addition to gender transitioning, are established correlates of psychological distress. In a statewide sample of 350 transgender adults, we investigated whether a history of violence and discrimination increased the odds of reporting lifetime suicidal ideation (SI) and whether differences in SI were predicted by gender transition status. Violence, discrimination, and transition status significantly predicted SI. Compare...

  6. Contracting for Statewide Student Achievement Tests: A Review. Department of Public Instruction 98-4.

    Science.gov (United States)

    Wisconsin State Legislative Audit Bureau, Madison.

    The Wisconsin legislature has required the Department of Public Instruction to adopt or approve standardized tests for statewide use to measure student attainment of knowledge and concepts in grades 4, 8, and 10. Although school districts generally gave high ratings to the contents of TerraNova (McGraw Hill), the testing instrument most recently…

  7. Prevalence of Internet gaming disorder in German adolescents: diagnostic contribution of the nine DSM-5 criteria in a state-wide representative sample.

    Science.gov (United States)

    Rehbein, Florian; Kliem, Sören; Baier, Dirk; Mößle, Thomas; Petry, Nancy M

    2015-05-01

    Internet gaming disorder (IGD) is included as a condition for further study in Section 3 of the DSM-5. Nine criteria were proposed with a threshold of five or more criteria recommended for diagnosis. The aims of this study were to assess how the specific criteria contribute to diagnosis and to estimate prevalence rates of IGD based on DSM-5 recommendations. Large-scale, state-representative school survey using a standardized questionnaire. Germany (Lower Saxony). A total of 11 003 ninth-graders aged 13-18 years (mean = 14.88, 51.09% male). IGD was assessed with a DSM-5 adapted version of the Video Game Dependency Scale that covered all nine criteria of IGD. In total, 1.16% [95% confidence interval (CI) = 0.96, 1.36] of respondents were classified with IGD according to DSM-5 recommendations. IGD students played games for longer periods, skipped school more often, had lower grades in school, reported more sleep problems and more often endorsed feeling 'addicted to gaming' than their non-IGD counterparts. The most frequently reported DSM-5 criteria overall were 'escape adverse moods' (5.30%) and 'preoccupation' (3.91%), but endorsement of these criteria rarely related to IGD diagnosis. Conditional inference trees showed that the criteria 'give up other activities', 'tolerance' and 'withdrawal' were of key importance for identifying IGD as defined by DSM-5. Based on a state-wide representative school survey in Germany, endorsement of five or more criteria of DSM-5 internet gaming disorder (IGD) occurred in 1.16% of the students, and these students evidence greater impairment compared with non-IGD students. Symptoms related to 'give up other activities', 'tolerance' and 'withdrawal' are most relevant for IGD diagnosis in this age group. © 2015 Society for the Study of Addiction.

  8. Health information exchange implementation: lessons learned and critical success factors from a case study.

    Science.gov (United States)

    Feldman, Sue S; Schooley, Benjamin L; Bhavsar, Grishma P

    2014-08-15

    Much attention has been given to the proposition that the exchange of health information as an act, and health information exchange (HIE), as an entity, are critical components of a framework for health care change, yet little has been studied to understand the value proposition of implementing HIE with a statewide HIE. Such an organization facilitates the exchange of health information across disparate systems, thus following patients as they move across different care settings and encounters, whether or not they share an organizational affiliation. A sociotechnical systems approach and an interorganizational systems framework were used to examine implementation of a health system electronic medical record (EMR) system onto a statewide HIE, under a cooperative agreement with the Office of the National Coordinator for Health Information Technology, and its collaborating organizations. The objective of the study was to focus on the implementation of a health system onto a statewide HIE; provide insight into the technical, organizational, and governance aspects of a large private health system and the Virginia statewide HIE (organizations with the shared goal of exchanging health information); and to understand the organizational motivations and value propositions apparent during HIE implementation. We used a formative evaluation methodology to investigate the first implementation of a health system onto the statewide HIE. Qualitative methods (direct observation, 36 hours), informal information gathering, semistructured interviews (N=12), and document analysis were used to gather data between August 12, 2012 and June 24, 2013. Derived from sociotechnical concepts, a Blended Value Collaboration Enactment Framework guided the data gathering and analysis to understand organizational stakeholders' perspectives across technical, organizational, and governance dimensions. Several challenges, successes, and lessons learned during the implementation of a health system to the

  9. Primary care COPD patients compared with large pharmaceutically-sponsored COPD studies: an UNLOCK validation study.

    Directory of Open Access Journals (Sweden)

    Annemarije L Kruis

    Full Text Available BACKGROUND: Guideline recommendations for chronic obstructive pulmonary disease (COPD are based on the results of large pharmaceutically-sponsored COPD studies (LPCS. There is a paucity of data on disease characteristics at the primary care level, while the majority of COPD patients are treated in primary care. OBJECTIVE: We aimed to evaluate the external validity of six LPCS (ISOLDE, TRISTAN, TORCH, UPLIFT, ECLIPSE, POET-COPD on which current guidelines are based, in relation to primary care COPD patients, in order to inform future clinical practice guidelines and trials. METHODS: Baseline data of seven primary care databases (n=3508 from Europe were compared to baseline data of the LPCS. In addition, we examined the proportion of primary care patients eligible to participate in the LPCS, based on inclusion criteria. RESULTS: Overall, patients included in the LPCS were younger (mean difference (MD-2.4; p=0.03, predominantly male (MD 12.4; p=0.1 with worse lung function (FEV1% MD -16.4; p<0.01 and worse quality of life scores (SGRQ MD 15.8; p=0.01. There were large differences in GOLD stage distribution compared to primary care patients. Mean exacerbation rates were higher in LPCS, with an overrepresentation of patients with ≥ 1 and ≥ 2 exacerbations, although results were not statistically significant. Our findings add to the literature, as we revealed hitherto unknown GOLD I exacerbation characteristics, showing 34% of mild patients had ≥ 1 exacerbations per year and 12% had ≥ 2 exacerbations per year. The proportion of primary care patients eligible for inclusion in LPCS ranged from 17% (TRISTAN to 42% (ECLIPSE, UPLIFT. CONCLUSION: Primary care COPD patients stand out from patients enrolled in LPCS in terms of gender, lung function, quality of life and exacerbations. More research is needed to determine the effect of pharmacological treatment in mild to moderate patients. We encourage future guideline makers to involve primary care

  10. Teaching Large Sections of a Business Communication Course: A Multicase Study

    Science.gov (United States)

    Wright, Carol

    2017-01-01

    The purpose of this research is to examine specific examples of how business communication courses are delivered in large, face-to-face university classes to discover implications of these large courses. This case study reviewed four classes from two different midsized universities whose classes range from 48 to 300 students. Findings suggest…

  11. Reliability, availability and maintenance aspects of large-scale offshore wind farms, a concepts study

    NARCIS (Netherlands)

    Van Bussel, G.J.W.; Zaayer, M.B.

    2001-01-01

    The DOWEC projects aims at implementation of large wind turbines in large scale wind farms. part of the DOWEC project a concepts study was performed regarding the achievable reliability and availability levels. A reduction with a factor of 2 with regard to the present state of the art seems fairly

  12. Perceptions of electronic health record implementation: a statewide survey of physicians in Rhode Island.

    Science.gov (United States)

    Wylie, Matthew C; Baier, Rosa R; Gardner, Rebekah L

    2014-10-01

    Although electronic health record use improves healthcare delivery, adoption into clinical practice is incomplete. We sought to identify the extent of adoption in Rhode Island and the characteristics of physicians and electronic health records associated with positive experience. We performed a cross-sectional study of data collected by the Rhode Island Department of Health for the Health Information Technology Survey 2009 to 2013. Survey questions included provider and practice demographics, health record information, and Likert-type scaled questions regarding how electronic health record use affected clinical practice. The survey response rate ranged from 50% to 65%, with 62% in 2013. Increasing numbers of physicians in Rhode Island use an electronic health record. In 2013, 81% of physicians used one, and adoption varied by clinical subspecialty. Most providers think that electronic health record use improves billing and quality improvement but has not improved job satisfaction. Physicians with longer and more sophisticated electronic health record use report positive effects of introduction on all aspects of practice examined (P electronic health record introduction (P electronic health record vendors most frequently used in Rhode Island, 5 were associated with improved job satisfaction. We report the largest statewide study of electronic health record adoption to date. We found increasing physician use in Rhode Island, and the extent of adoption varies by subspecialty. Although older physicians are less likely to be positive about electronic health record adoption, longer and more sophisticated use are associated with more positive opinions, suggesting acceptance will grow over time. Copyright © 2014 Elsevier Inc. All rights reserved.

  13. Statewide prevalence of school children at risk of anaphylaxis and rate of adrenaline autoinjector activation in Victorian government schools, Australia.

    Science.gov (United States)

    Loke, Paxton; Koplin, Jennifer; Beck, Cara; Field, Michael; Dharmage, Shyamali C; Tang, Mimi L K; Allen, Katrina J

    2016-08-01

    The prevalence of school students at risk of anaphylaxis in Victoria is unknown and has not been previously studied. Similarly, rates of adrenaline autoinjector usage in the school environment have yet to be determined given increasing prescription rates. We sought to determine time trends in prevalence of school children at risk of anaphylaxis across all year levels and the annual usage rate of adrenaline autoinjectors in the school setting relative to the number of students at risk of anaphylaxis. Statewide surveys from more than 1,500 government schools including more than 550,000 students were used and prevalence rates (%) with 95% CIs were calculated. The overall prevalence of students at risk of anaphylaxis has increased 41% from 0.98% (95% CI, 0.95-1.01) in 2009 to 1.38% (95% CI, 1.35-1.41) in 2014. There was a significant drop in reporting of anaphylaxis risk with transition from the final year of primary school to the first year of secondary school, suggesting a change in parental reporting of anaphylaxis risk among secondary school students. The number of adrenaline autoinjectors activated per 1000 students at risk of anaphylaxis ranged from 6 to 8 per year, with consistently higher activation use in secondary school students than in primary school students. Statewide prevalence of anaphylaxis risk has increased in children attending Victorian government schools. However, adrenaline autoinjector activation has remained fairly stable despite known increase in the rates of prescription. Copyright © 2016 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

  14. AN EXPANDED VERY LARGE ARRAY AND CARMA STUDY OF DUSTY DISKS AND TORII WITH LARGE GRAINS IN DYING STARS

    International Nuclear Information System (INIS)

    Sahai, R.; Claussen, M. J.; Schnee, S.; Morris, M. R.; Sanchez Contreras, C.

    2011-01-01

    We report the results of a pilot multiwavelength survey in the radio continuum (X, Ka, and Q bands, i.e., from 3.6 cm to 7 mm) carried out with the Expanded Very Large Array (EVLA) in order to confirm the presence of very large dust grains in dusty disks and torii around the central stars in a small sample of post-asymptotic giant branch (pAGB) objects, as inferred from millimeter (mm) and submillimeter (submm) observations. Supporting mm-wave observations were also obtained with the Combined Array for Research in Millimeter-wave Astronomy toward three of our sources. Our EVLA survey has resulted in a robust detection of our most prominent submm emission source, the pre-planetary nebula (PPN) IRAS 22036+5306, in all three bands, and the disk-prominent pAGB object, RV Tau, in one band. The observed fluxes are consistent with optically thin free-free emission, and since they are insignificant compared to their submm/mm fluxes, we conclude that the latter must come from substantial masses of cool, large (mm-sized) grains. We find that the power-law emissivity in the cm-to-submm range for the large grains in IRAS22036 is ν β , with β = 1-1.3. Furthermore, the value of β in the 3-0.85 mm range for the three disk-prominent pAGB sources (β ≤ 0.4) is significantly lower than that of IRAS22036, suggesting that the grains in pAGB objects with circumbinary disks are likely larger than those in the dusty waists of pre-planetary nebulae.

  15. Development of a central data warehouse for statewide ITS and transportation data in Florida phase III : final report.

    Science.gov (United States)

    2009-12-15

    This report documents Phase III of the development and operation of a prototype for the Statewide Transportation : Engineering Warehouse for Archived Regional Data (STEWARD). It reflects the progress on the development and : operation of STEWARD sinc...

  16. The subjective experience of the self in the large group: two models for study.

    Science.gov (United States)

    Shields, W

    2001-04-01

    More and more opportunities now exist for group therapists to engage in the study of the self in the large group at local, national, and international conferences as well as in clinical and other organizational settings. This may be particularly important for the group therapist in the next century with potential benefit not only for individuals but also for groups and social systems of all kinds. In this article, I review my own subjective experiences in the large group context and in large study group experiences. Then, I contrast the group analytic and the group relations approaches to the large group with particular reference to Winnicott's theory about maturational processes in a facilitating environment.

  17. Cost-effectiveness analysis of a statewide media campaign to promote adolescent physical activity.

    Science.gov (United States)

    Peterson, Michael; Chandlee, Margaret; Abraham, Avron

    2008-10-01

    A cost-effectiveness analysis of a statewide social marketing campaign was performed using a statewide surveillance survey distributed to 6th through 12th graders, media production and placement costs, and 2000 census data. Exposure to all three advertisements had the highest impact on both intent and behavior with 65.6% of the respondents considering becoming more active and 58.3% reporting becoming more active. Average cost of the entire campaign was $4.01 per person to see an ad, $7.35 per person to consider being more active, and $8.87 per person to actually become more active, with billboards yielding the most positive cost-effectiveness. Findings highlight market research as an essential part of social marketing campaigns and the importance of using multiple marketing modalities to enhance cost-effectiveness and impact.

  18. A task force model for statewide change in nursing education: building quality and safety.

    Science.gov (United States)

    Mundt, Mary H; Clark, Margherita Procaccini; Klemczak, Jeanette Wrona

    2013-01-01

    The purpose of this article was to describe a statewide planning process to transform nursing education in Michigan to improve quality and safety of patient care. A task force model was used to engage diverse partners in issue identification, consensus building, and recommendations. An example of a statewide intervention in nursing education and practice that was executed was the Michigan Quality and Safety in Nursing Education Institute, which was held using an integrated approach to academic-practice partners from all state regions. This paper describes the unique advantage of leadership by the Michigan Chief Nurse Executive, the existence of a nursing strategic plan, and a funding model. An overview of the Task Force on Nursing Education is presented with a focus on the model's 10 process steps and resulting seven recommendations. The Michigan Nurse Education Council was established to implement the recommendations that included quality and safety. Copyright © 2013 Elsevier Inc. All rights reserved.

  19. Collective design in 3D printing: A large scale empirical study of designs, designers and evolution

    DEFF Research Database (Denmark)

    Özkil, Ali Gürcan

    2017-01-01

    This paper provides an empirical study of a collective design platform (Thingiverse); with the aim of understanding the phenomenon and investigating how designs concurrently evolve through the large and complex network of designers. The case study is based on the meta-data collected from 158 489 ...

  20. The Need for Large-Scale, Longitudinal Empirical Studies in Middle Level Education Research

    Science.gov (United States)

    Mertens, Steven B.; Caskey, Micki M.; Flowers, Nancy

    2016-01-01

    This essay describes and discusses the ongoing need for large-scale, longitudinal, empirical research studies focused on middle grades education. After a statement of the problem and concerns, the essay describes and critiques several prior middle grades efforts and research studies. Recommendations for future research efforts to inform policy…

  1. Predictors of switching from mania to depression in a large observational study across Europe (EMBLEM)

    NARCIS (Netherlands)

    Vieta, Eduard; Angst, Jules; Reed, Catherine; Bertsch, Jordan; Maria Haro, Josep

    Background: The risk of switching from mania to depression in bipolar disorder has been poorly studied. Large observational studies may be useful in identifying variables that predict switch to depression after mania and provide data on medication use and outcomes in "real world" patients. Method:

  2. Predictors of switching from mania to depression in a large observational study across Europe (EMBLEM)

    NARCIS (Netherlands)

    Vieta, Eduard; Angst, Jules; Reed, Catherine; Bertsch, Jordan; Maria Haro, Josep

    2009-01-01

    Background: The risk of switching from mania to depression in bipolar disorder has been poorly studied. Large observational studies may be useful in identifying variables that predict switch to depression after mania and provide data on medication use and outcomes in "real world" patients. Method:

  3. Building Statewide Infrastructure for the Academic Support of Students With Mild Traumatic Brain Injury.

    Science.gov (United States)

    Gioia, Gerard A; Glang, Ann E; Hooper, Stephen R; Brown, Brenda Eagan

    To focus attention on building statewide capacity to support students with mild traumatic brain injury (mTBI)/concussion. Consensus-building process with a multidisciplinary group of clinicians, researchers, policy makers, and state Department of Education personnel. The white paper presents the group's consensus on the essential components of a statewide educational infrastructure to support the management of students with mTBI. The nature and recovery process of mTBI are briefly described specifically with respect to its effects on school learning and performance. State and local policy considerations are then emphasized to promote implementation of a consistent process. Five key components to building a statewide infrastructure for students with mTBI are described including (1) definition and training of the interdisciplinary school team, (2) professional development of the school and medical communities, (3) identification, assessment, and progress monitoring protocols, (4) a flexible set of intervention strategies to accommodate students' recovery needs, and (5) systematized protocols for active communication among medical, school, and family team members. The need for a research to guide effective program implementation is stressed. This guiding framework strives to assist the development of support structures for recovering students with mTBI to optimize academic outcomes. Until more evidence is available on academic accommodations and other school-based supports, educational systems should follow current best practice guidelines.

  4. Statewide screening for low-level radioactive waste shallow land burial sites

    International Nuclear Information System (INIS)

    Staub, W.P.; Cannon, J.B.; Stratton, L.E.

    1984-01-01

    A methodology was developed for statewide low-level waste site screening based on NRC site selection criteria. The methodology and criteria were tested in Tennessee to determine their effectiveness in narrowing the choice of sites for more intensive localized site screening. The statewide screening methodology entailed two steps. The first step was to select one or more physiographic provinces wherein sites meeting the criteria were most likely to be found. The second step was to select one or more suitable outcrop bands from within the most favorable physiographic provinces. These selections were based entirely on examination of existing literature and maps at scales no larger than 1:250,000. The statewide screening project identified only one suitable physiographic province (the Mississippi Embayment region) and one favorable outcrop band (the Coon Creek Formation) within a three county area of western Tennessee. Ground water monitoring and predictability proved to be the most difficult criterion to meet. This criterion alone eliminated other outcrop bands in the Mississippi Embayment as well as the Eastern Highland Rim and Western Highland Rim physiographic provinces. Other provinces failed to meet several screening criteria. 3 references, 3 figures, 1 table

  5. Programs of quality improvement: an exploratory study in large Brazilian construction companies

    Directory of Open Access Journals (Sweden)

    Silvia Helena Boarin Pinto

    2009-03-01

    Full Text Available This article aims to identify the major characteristics of the implementation of quality programs in large construction companies in Brazil. This study focuses on the most accepted and implemented models such as ISO 9000:2000, ISO 14001, Six Sigma and Total Quality Management (TQM. An exploratory study was carried out in seven large companies (approximately 37% of the total number. These companies were chosen from the “500 Largest and Best Brazilian Companies” list, published by Exame Magazine, in 2005, out of a total number of 15 large companies in the sector. The indings of this study show that the companies have been implementing quality programs, have been using more basic quality tools, and have been dificulty accounting resources that come from the implementation of quality programs.

  6. Evaluation of a statewide science inservice and outreach program: Teacher and student outcomes

    Science.gov (United States)

    Lott, Kimberly Hardiman

    Alabama Science in Motion (ASIM) is a statewide in-service and outreach program designed to provide in-service training for teachers in technology and content knowledge. ASIM is also designed to increase student interest in science and future science careers. The goals of ASIM include: to complement, enhance and facilitate implementation of the Alabama Course of Study: Science, to increase student interest in science and scientific careers, and to provide high school science teachers with curriculum development and staff development opportunities that will enhance their subject-content expertise, technology background, and instructional skills. This study was conducted to evaluate the goals and other measurable outcomes of the chemistry component of ASIM. Data were collected from 19 chemistry teachers and 182 students that participated in ASIM and 6 chemistry teachers and 42 students that do not participate in ASIM using both surveys and student records. Pre-treatment Chi-Square tests revealed that the teachers did not differ in years of chemistry teaching experience, major in college, and number of classes other than chemistry taught. Pre-treatment Chi-Square tests revealed that the students did not differ in age, ethnicity, school classification, or school type. The teacher survey used measured attitudes towards inquiry-based teaching, frequency of technology used by teacher self-report and perceived teaching ability of chemistry topics from the Alabama Course of Study-Science. The student surveys used were the Test of Science Related Attitudes (TOSRA) and a modified version of the Test of Integrated Process Skills (TIPS). The students' science scores from the Stanford Achievement Test (SAT-9) were also obtained from student records. Analysis of teacher data using a MANOVA design revealed that participation in ASIM had a significantly positive effect on teacher attitude towards inquiry-based teaching and the frequency of technology used; however, there was no

  7. Initial Technology Assessment for the Large UV-Optical-Infrared (LUVOIR) Mission Concept Study

    Science.gov (United States)

    Bolcar, Matthew R.; Feinberg, Lee D.; France, Kevin; Rauscher, Bernard J.; Redding, David; Schiminovich, David

    2016-01-01

    The NASA Astrophysics Divisions 30-Year Roadmap prioritized a future large-aperture space telescope operating in the ultra-violet-optical-infrared wavelength regime. The Association of Universities for Research in Astronomy envisioned a similar observatory, the High Definition Space Telescope. And a multi-institution group also studied the Advanced Technology Large Aperture Space Telescope. In all three cases, a broad science case is outlined, combining general astrophysics with the search for bio-signatures via direct-imaging and spectroscopic characterization of habitable exo-planets. We present an initial technology assessment that enables such an observatory that is currently being studied for the 2020 Decadal Survey by the Large UV-Optical Infrared (LUVOIR) surveyor Science and Technology Definition Team. We present here the technology prioritization for the 2016 technology cycle and define the required technology capabilities and current state-of-the-art performance. Current, planned, and recommended technology development efforts are also reported.

  8. Initial Technology Assessment for the Large-Aperture UV-Optical-Infrared (LUVOIR) Mission Concept Study

    Science.gov (United States)

    Bolcar, Matthew R.; Feinberg, Lee; France, Kevin; Rauscher, Bernard J.; Redding, David; Schiminovich, David

    2016-01-01

    The NASA Astrophysics Division's 30-Year Roadmap prioritized a future large-aperture space telescope operating in the ultra-violet/optical/infrared wavelength regime. The Association of Universities for Research in Astronomy envisioned a similar observatory, the High Definition Space Telescope. And a multi-institution group also studied the Advanced Technology Large Aperture Space Telescope. In all three cases, a broad science case is outlined, combining general astrophysics with the search for biosignatures via direct-imaging and spectroscopic characterization of habitable exoplanets. We present an initial technology assessment that enables such an observatory that is currently being studied for the 2020 Decadal Survey by the Large UV/Optical/Infrared (LUVOIR) surveyor Science and Technology Definition Team. We present here the technology prioritization for the 2016 technology cycle and define the required technology capabilities and current state-of-the-art performance. Current, planned, and recommended technology development efforts are also reported.

  9. Human bromethalin exposures reported to a U.S. Statewide Poison Control System.

    Science.gov (United States)

    Huntington, Serena; Fenik, Yelena; Vohra, Rais; Geller, Richard J

    2016-03-01

    Bromethalin is an increasingly used alternative to long-acting anticoagulant and cholecalciferol rodenticides. There are few reports of human exposures, and no existing professional society guidelines on medical management of bromethalin ingestions. The aim of this retrospective data review is to characterize bromethalin exposures reported to the California Poison Control System (CPCS) between 1997 and 2014. This is an observational retrospective case review of our statewide poison control system's electronic medical records. Following Institutional Board Review and Research Committee approvals, poison center exposures related to bromethalin were extracted using substance code and free text search strategies. Case notes of bromethalin exposures were reviewed for demographic, clinical, laboratory, and outcome information; inclusion criteria for the study was single-substance, human exposure to bromethalin. There were 129 calls related to human bromethalin exposures (three cases met exclusion criteria). The age range of cases was 7 months-90 years old, with the majority of exposures (89 cases; 70.6%), occurring in children younger than 5 years of age (median age of 2 years). Most exposures occurred in the pediatric population as a result of exploratory oral exposure. One hundred and thirteen patients (89.7%) had no effects post exposure, while 10 patients (7.9%) had a minor outcome. Adverse effects were minor, self-limited, and mostly gastrointestinal upset. There were no moderate, major, or fatal effects in our study population. The approximate ingested dose, available in six cases, ranged from 0.067 mg/kg to 0.3 mg/kg (milligrams of bromethalin ingested per kilogram of body weight), and no dose-symptom threshold could be established from this series. Exposures were not confirmed through urine or serum laboratory testing. The prognosis for most accidental ingestions appears to be excellent. However, bromethalin exposures may result in a higher number of

  10. Methods and Management of the Healthy Brain Study: A Large Multisite Qualitative Research Project

    Science.gov (United States)

    Laditka, Sarah B.; Corwin, Sara J.; Laditka, James N.; Liu, Rui; Friedman, Daniela B.; Mathews, Anna E.; Wilcox, Sara

    2009-01-01

    Purpose of the study: To describe processes used in the Healthy Brain project to manage data collection, coding, and data distribution in a large qualitative project, conducted by researchers at 9 universities in 9 states. Design and Methods: Project management protocols included: (a) managing audiotapes and surveys to ensure data confidentiality,…

  11. Acceptance of Driverless Vehicles : Results from a Large Cross-National Questionnaire Study

    NARCIS (Netherlands)

    Nordhoff, S.; de Winter, J.C.F.; Kyriakidis, M.; van Arem, B.; Happee, R.

    2018-01-01

    Shuttles that operate without an onboard driver are currently being developed and tested in various projects worldwide. However, there is a paucity of knowledge on the determinants of acceptance of driverless shuttles in large cross-national samples. In the present study, we surveyed 10,000

  12. Large-scale agent-based social simulation : A study on epidemic prediction and control

    NARCIS (Netherlands)

    Zhang, M.

    2016-01-01

    Large-scale agent-based social simulation is gradually proving to be a versatile methodological approach for studying human societies, which could make contributions from policy making in social science, to distributed artificial intelligence and agent technology in computer science, and to theory

  13. Maternal cortisol and offspring birthweight: results from a large prospective cohort study

    NARCIS (Netherlands)

    Goedhart, G.; Vrijkotte, T.G.M.; Roseboom, T.J.; van der Wal, M.F.; Cuijpers, P.; Bonsel, G.J.

    2010-01-01

    Maternal psychosocial problems may affect fetal growth through maternal cortisol. This large prospective cohort study examined among 2810 women (1) the association of maternal cortisol levels with offspring birthweight and small for gestational age (SGA) risk and (2) the mediating role of maternal

  14. Transanal endoscopic microsurgery versus endoscopic mucosal resection for large rectal adenomas (TREND-study)

    NARCIS (Netherlands)

    F.J.C. van den Broek (Frank); E.J.R. de Graaf (Eelco); M.G.W. Dijkgraaf (Marcel); J.B. Reitsma (Johannes); J. Haringsma (Jelle); R. Timmer (Robin); B.L. Weusten (Bas); M.F. Gerhards (Michael); E.C. Consten (Esther); M.P. Schwartz (Matthijs); M.J. Boom (Maarten); E.J. Derksen (Erik); A.B. Bijnen (Bart); P.H.P. Davids (Paul); C. Hoff (Christiaan); H.M. van Dullemen (Hendrik); G.D.N. Heine (Dimitri); K. van der Linde (Klaas); J.M. Jansen (Jeroen); R.C.H. Mallant-Hent (Rosalie); R. Breumelhof (Ronald); H. Geldof (Han); J.C. Hardwick (James); P. Doornebosch (Pascal); A.C.T.M. Depla (Annekatrien); M.F. Ernst (Miranda); I.P. van Munster (Ivo); I.H.J.T. de Hingh (Ignace); E.J. Schoon (Erik); W.A. Bemelman (Willem); P. Fockens (Paul); E. Dekker (Evelien)

    2009-01-01

    textabstractBackground: Recent non-randomized studies suggest that extended endoscopic mucosal resection (EMR) is equally effective in removing large rectal adenomas as transanal endoscopic microsurgery (TEM). If equally effective, EMR might be a more cost-effective approach as this strategy does

  15. Transanal endoscopic microsurgery versus endoscopic mucosal resection for large rectal adenomas (TREND-study)

    NARCIS (Netherlands)

    van den Broek, Frank J. C.; de Graaf, Eelco J. R.; Dijkgraaf, Marcel G. W.; Haringsma, Jelle; Timmer, Robin; Weusten, Bas L. A. M.; Gerhards, Michael F.; Consten, Esther C. J.; Schwartz, Matthijs P.; Boom, Maarten J.; Derksen, Erik J.; Bijnen, A. Bart; Davids, Paul H. P.; Hoff, Christiaan; van Dullemen, Hendrik M.; Heine, G. Dimitri N.; van der Linde, Klaas; Jansen, Jeroen M.; Mallant-Hent, Rosalie C. H.; Breumelhof, Ronald; Geldof, Han; Hardwick, James C. H.; Doornebosch, Pascal G.; Depla, Annekatrien C. T. M.; Ernst, Miranda F.; van Munster, Ivo P.; de Hingh, Ignace H. J. T.; Schoon, Erik J.; Bemelman, Willem A.; Fockens, Paul; Dekker, Evelien; Reitsma, J.

    2009-01-01

    Background: Recent non-randomized studies suggest that extended endoscopic mucosal resection (EMR) is equally effective in removing large rectal adenomas as transanal endoscopic microsurgery (TEM). If equally effective, EMR might be a more cost-effective approach as this strategy does not require

  16. Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma

    NARCIS (Netherlands)

    Cerhan, James R.; Berndt, Sonja I.; Vijai, Joseph; Ghesquières, Hervé; McKay, James; Wang, Sophia S.; Wang, Zhaoming; Yeager, Meredith; Conde, Lucia; De Bakker, Paul I W; Nieters, Alexandra; Cox, David; Burdett, Laurie; Monnereau, Alain; Flowers, Christopher R.; De Roos, Anneclaire J.; Brooks-Wilson, Angela R.; Lan, Qing; Severi, Gianluca; Melbye, Mads; Gu, Jian; Jackson, Rebecca D.; Kane, Eleanor; Teras, Lauren R.; Purdue, Mark P.; Vajdic, Claire M.; Spinelli, John J.; Giles, Graham G.; Albanes, Demetrius; Kelly, Rachel S.; Zucca, Mariagrazia; Bertrand, Kimberly A.; Zeleniuch-Jacquotte, Anne; Lawrence, Charles; Hutchinson, Amy; Zhi, Degui; Habermann, Thomas M.; Link, Brian K.; Novak, Anne J.; Dogan, Ahmet; Asmann, Yan W.; Liebow, Mark; Thompson, Carrie A.; Ansell, Stephen M.; Witzig, Thomas E.; Weiner, George J.; Veron, Amelie S.; Zelenika, Diana; Tilly, Hervé; Haioun, Corinne; Molina, Thierry Jo; Hjalgrim, Henrik; Glimelius, Bengt; Adami, Hans Olov; Bracci, Paige M.; Riby, Jacques; Smith, Martyn T.; Holly, Elizabeth A.; Cozen, Wendy; Hartge, Patricia; Morton, Lindsay M.; Severson, Richard K.; Tinker, Lesley F.; North, Kari E.; Becker, Nikolaus; Benavente, Yolanda; Boffetta, Paolo; Brennan, Paul; Foretova, Lenka; Maynadie, Marc; Staines, Anthony; Lightfoot, Tracy; Crouch, Simon; Smith, Alex; Roman, Eve; Diver, W. Ryan; Offit, Kenneth; Zelenetz, Andrew; Klein, Robert J.; Villano, Danylo J.; Zheng, Tongzhang; Zhang, Yawei; Holford, Theodore R.; Kricker, Anne; Turner, Jenny; Southey, Melissa C.; Clavel, Jacqueline; Virtamo, Jarmo; Weinstein, Stephanie; Riboli, Elio; Vineis, Paolo; Kaaks, Rudolph; Trichopoulos, Dimitrios; Vermeulen, Roel C H; Boeing, Heiner; Tjonneland, Anne; Angelucci, Emanuele; Di Lollo, Simonetta; Rais, Marco; Birmann, Brenda M.; Laden, Francine; Giovannucci, Edward; Kraft, Peter; Huang, Jinyan; Ma, Baoshan; Ye, Yuanqing; Chiu, Brian C H; Sampson, Joshua; Liang, Liming; Park, Ju Hyun; Chung, Charles C.; Weisenburger, Dennis D.; Chatterjee, Nilanjan; Fraumeni, Joseph F.; Slager, Susan L.; Wu, Xifeng; De Sanjose, Silvia; Smedby, Karin E.; Salles, Gilles; Skibola, Christine F.; Rothman, Nathaniel; Chanock, Stephen J.

    2014-01-01

    Diffuse large B cell lymphoma (DLBCL) is the most common lymphoma subtype and is clinically aggressive. To identify genetic susceptibility loci for DLBCL, we conducted a meta-analysis of 3 new genome-wide association studies (GWAS) and 1 previous scan, totaling 3,857 cases and 7,666 controls of

  17. National studies on recidivism: an inventory of large-scale recidivism research in 33 European countries

    NARCIS (Netherlands)

    Wartna, B.S.J.; Nijssen, L.T.J.

    2006-01-01

    Measuring recidivism is an established method for examining the effects of penal interventions. Over the last decades the automation of police and judiciary data has opened up opportunities to do large-scale recidivism research. The WODC has made an inventory of the studies that are carried out in

  18. Software engineering the mixed model for genome-wide association studies on large samples

    Science.gov (United States)

    Mixed models improve the ability to detect phenotype-genotype associations in the presence of population stratification and multiple levels of relatedness in genome-wide association studies (GWAS), but for large data sets the resource consumption becomes impractical. At the same time, the sample siz...

  19. Large shear deformation of particle gels studied by Brownian Dynamics simulations

    NARCIS (Netherlands)

    Rzepiela, A.A.; Opheusden, van J.H.J.; Vliet, van T.

    2004-01-01

    Brownian Dynamics (BD) simulations have been performed to study structure and rheology of particle gels under large shear deformation. The model incorporates soft spherical particles, and reversible flexible bond formation. Two different methods of shear deformation are discussed, namely affine and

  20. Study on superhigh energy γ-ray family events with large-scale Fe emulsion chambers

    International Nuclear Information System (INIS)

    Ren Jingru; Lu Suiling; Su Shi

    1990-01-01

    Using a large-scale iron emulsion chamber, a big γ-ray family event with observed energy ΣE r = 7631 TeV was obtained. This paper described the advantages of iron emulsion chamber for studying big families and the characteristics of the event observed, together with a comparison with the Monte-Carlo simulation results

  1. Case Study: Mini-Case Studies: Small Infusions of Active Learning for Large-Lecture Courses

    Science.gov (United States)

    Carloye, Lisa

    2017-01-01

    In this article, the author introduces the usage of case studies to be an excellent method for engaging students through stories. The author notes she developed a series of mini-case studies that can be implemented, with a little advance preparation, within a 10- to 15-minute window during lecture. What makes them "mini" case studies?…

  2. The problem of large samples. An activation analysis study of electronic waste material

    International Nuclear Information System (INIS)

    Segebade, C.; Goerner, W.; Bode, P.

    2007-01-01

    Large-volume instrumental photon activation analysis (IPAA) was used for the investigation of shredded electronic waste material. Sample masses from 1 to 150 grams were analyzed to obtain an estimate of the minimum sample size to be taken to achieve a representativeness of the results which is satisfactory for a defined investigation task. Furthermore, the influence of irradiation and measurement parameters upon the quality of the analytical results were studied. Finally, the analytical data obtained from IPAA and instrumental neutron activation analysis (INAA), both carried out in a large-volume mode, were compared. Only parts of the values were found in satisfactory agreement. (author)

  3. Large-field image intensifiers versus conventional chest radiography: ROC study with simulated interstitial disease

    International Nuclear Information System (INIS)

    Winter, L.H.L.; Chakraborty, D.P.; Waes, P.F.G.M.

    1988-01-01

    Two image intensifier tubes have recently been introduced whose large imaging area makes them suitable for chest imaging (Phillips Pulmodiagnost TLX slit II and Siemens TX 57 large entrance field II). Both modalities present a 10 x 10-cm hard copy image to the radiologist. A receiver operating characteristic (ROC) curve study with simulated interstitial disease was performed to compare the image quality of these image intensifiers with conventional chest images. The relative ranking in terms of decreasing ROC areas was Siemens, conventional, and Philips. Compared with conventional imaging, none of the differences in ROC curve area were statistically significant at the 5% level

  4. Large Sample Neutron Activation Analysis: A Challenge in Cultural Heritage Studies

    International Nuclear Information System (INIS)

    Stamatelatos, I.E.; Tzika, F.

    2007-01-01

    Large sample neutron activation analysis compliments and significantly extends the analytical tools available for cultural heritage and authentication studies providing unique applications of non-destructive, multi-element analysis of materials that are too precious to damage for sampling purposes, representative sampling of heterogeneous materials or even analysis of whole objects. In this work, correction factors for neutron self-shielding, gamma-ray attenuation and volume distribution of the activity in large volume samples composed of iron and ceramic material were derived. Moreover, the effect of inhomogeneity on the accuracy of the technique was examined

  5. Study of a large BGO crystal in a charged particle beam

    International Nuclear Information System (INIS)

    Zhang, N.; Ding, Z.; Wu, Y.; Salomon, M.

    1990-01-01

    We have studied two large crystals of Bismuth Germanate (BGO) with sources and in a pion beam. The response and uniformity have been investigated with several types of reflectors. The temperature dependance of the emitted light was determined, as well as the timing resolution. As the crystal is intended to be part of a large array with very good energy resolution in the detection of high energy gamma rays and electrons, uniformities of better than 0.5% are required. Various methods to achieve this will be discussed

  6. Heterogeneity among hospitals statewide in percentage shares of the annual growth of surgical caseloads of inpatient and outpatient major therapeutic procedures.

    Science.gov (United States)

    Dexter, Franklin; Jarvie, Craig; Epstein, Richard H

    2018-04-18

    Suppose that it were a generalizable finding, in both densely populated and rural states, that there is marked heterogeneity among hospitals in the percentage change in surgical caseload and/or in the total change in caseload. Then, individual hospitals should not simply rely on federal and state forecasts to infer their expected growth. Likewise, individual hospitals and their anesthesiology groups would best not rely on national or US regional surgical trends as causal reasons for local trends in caseload. We examined the potential utility of using state data on surgical caseload to predict local growth by using 6 years of data for surgical cases performed at hospitals in the States of Florida and Iowa. Observational cohort study. 303 hospitals in Iowa and Florida. Cases with major therapeutic procedures in 2010 or 2011 were compared pairwise by hospital with such cases in 2015 and 2016. Changes in counts of cases were decreases or increases, while study of growth set decreases equal to zero. Hospitals in Iowa had slightly lesser percentage changes than did hospitals in Florida (Mann-Whitney P = 0.016). Hospitals in Iowa had greater variability among hospitals in the change in counts of cases with a major therapeutic procedure than did hospitals in Florida (P < 0.0001). The 10% of hospitals with the largest growths in counts of cases accounted for approximately half of the total growth in Iowa (70%) and Florida (54%). The large share of total growth attributable to the upper 10th percentile of hospitals was not caused solely by the hospitals having large percentage growths, based on there being weak correlation between growth and percentage growth, among the hospitals that grew (Iowa: Kendall's tau = 0.286 [SE 0.120]; Florida tau = 0.253 [SE 0.064]). Even if the data from states or federal agencies reported growth in surgical cases, there is too much concentration of growth at a few hospitals for statewide growth rates to be useful for

  7. Background-oriented schlieren for the study of large flow fields

    Science.gov (United States)

    Trolinger, James D.; Buckner, Ben; L'Esperance, Drew

    2015-09-01

    Modern digital recording and processing techniques combined with new lighting methods and relatively old schlieren visualization methods move flow visualization to a new level, enabling a wide range of new applications and a possible revolution in the visualization of very large flow fields. This paper traces the evolution of schlieren imaging from Robert Hooke, who, in 1665, employed candles and lenses, to modern digital background oriented schlieren (BOS) systems, wherein image processing by computer replaces pure optical image processing. New possibilities and potential applications that could benefit from such a capability are examined. Example applications include viewing the flow field around full sized aircraft, large equipment and vehicles, monitoring explosions on bomb ranges, cooling systems, large structures and even buildings. Objectives of studies include aerodynamics, aero optics, heat transfer, and aero thermal measurements. Relevant digital cameras, light sources, and implementation methods are discussed.

  8. Large scale waste combustion projects. A study of financial structures and sensitivities

    International Nuclear Information System (INIS)

    Brandler, A.

    1993-01-01

    The principal objective of the study was to determine the key contractual and financial aspects of large scale energy-from-waste projects, and to provide the necessary background information on financing to appreciate the approach lenders take when they consider financing waste combustion projects. An integral part of the study has been the preparation of a detailed financial model, incorporating all major financing parameters, to assess the economic and financial viability of typical waste combustion projects. (author)

  9. Feasibility of studying large p/sub perpendicular to/ in ISABELLE's wide-angle hall

    International Nuclear Information System (INIS)

    Aronson, S.; Danby, G.; Engelmann, R.; Foley, K.; McCarthy, R.; Paige, F.; Pope, B.; Thorndike, A.

    1979-01-01

    The experimental area at 6 o'clock in the present ISABELLE site plan has a configuration suitable for studying particles produced at large angles relative to the beam lines. It is natural to think of housing a program of large p/perpendicular to/ studies in this area. A particular device has been considered, namely a pair of multiparticle spectrometers back-to-back at 90 0 to the beams, as a vehicle for carrying out this program. Enough details are presented to allow for a reasonable test of the planned 6 o'clock area as a site for such experiments. In summer, this study shows that a rather ambitious program of experiments can be performed in this area with some relatively easily implemented changes in the hall design

  10. Assessment of small versus large hydro-power developments - a Norwegian case study

    Energy Technology Data Exchange (ETDEWEB)

    Bakken, Tor Haakon; Harby, Atle

    2010-07-01

    Full text: The era of new, large hydro-power development projects seems to be over in Norway. Partly as a response to this, a large number of applications for the development of smallscale hydro power projects up to 10 MW overflow the Water Resources and Energy Directorate, resulting in an extensive development of small tributaries and water courses in Norway. This study has developed a framework for the assessment and comparison of several small versus many large hydro-power projects based on a multi-criteria analysis (MCA) approach, and further tested this approach on planned or developed projects in the Helgeland region, Norway. Multi-criteria analysis is a decision-support tool aimed at providing a systematic approach for the comparison of various alternatives with often non-commensurable and conflicting attributes. At the same time, the technique enables complex problems and various alternatives to be assessed in a transparent and simple way. The MCA-software was in our case equipped with 2 overall criteria (objectives) with a number of sub criteria; Production with sub-criteria like volume of energy production, installed effect, storage capacity and economical profit; Environmental impacts with sub-criteria like fishing interests, biodiversity, protection of unexploited nature The data used in the case study is based on the planned development of Vefsna (large project) with the energy/effect production estimated and the environmental impacts identified as part of the feasibility studies (the project never reached the authorities' licensing system with a formal EIA). The small-scale hydro-power projects used for comparison are based on realized projects in the Helgeland region and a number of proposed projects, up scaled to the size of the proposed Vefsna-development. The results from the study indicate that a large number of small-scale hydro-power projects need to be implemented in order to balance the volume of produced electricity/effect from one

  11. No thank you, not today": Supporting Ethical and Professional Relationships in Large Qualitative Studies

    Directory of Open Access Journals (Sweden)

    Lisa J. Blodgett

    2005-09-01

    Full Text Available Based on an ongoing research study of the development of self-regulation in early childhood (BOYER, 2005a, 2005b; BOYER, BLODGETT, & TURK, 2004, this work explores both the ethical and professional considerations of participant sampling in a large qualitative study. The study involved 146 families of preschool children and 15 educators across 7 preschools. Data collection included 30-45 minute audiotaped individual interviews, twenty-eight 90-120 minute audiotaped focus group sessions, and 30 minute videotaped footage of each child's natural play. The challenge of gaining informed consent and ongoing participation within a large study has been considered in the literature (GALL, GALL, & BORG, 2005. In qualitative studies the participants are selected purposefully because they will be par­ticularly informative about the topic (CRESWELL, 2002. This is a challenge for qualitative re­searchers seeking maximal participation and large sample sizes because volunteer participants "tend to be better educated, higher socioeconomically, more intelligent, more in need of social approval, more sociable, more unconventional, less auth­ori­tarian, and less conforming than nonvolunteers" (MCMILLAN, 2004, p.116. This paper provides a response to these sampling challenges and ad­vo­cates for the building of community relationships based on ethical, interpersonal and professional foundations. URN: urn:nbn:de:0114-fqs0503353

  12. Retail private label’s strategies: A case study in a large brazilian Supermarket chain.

    Directory of Open Access Journals (Sweden)

    Paula Bulamah Spineli

    2006-12-01

    Full Text Available The present study approaches the advantages and risks related to private labels under a retailers’ perspective, as well as the private label strategies and its growth in the Brazilian market. The paper analyses the strategies used by a large Brazilian supermarket chain with regards to its private labels’ management, using the case study method. The results showed the existence of two private label lines of products, with different strategies: one line of light products (proprietary brand and another line of products that carry the name of the supermarket under study (retail brand endorsement, both classified as using the fantasy positioning strategy.

  13. A Study on Developing and Refining a Large Citation Service System

    Directory of Open Access Journals (Sweden)

    Kwang-Young Kim

    2013-06-01

    Full Text Available Today, citation index information is used as an outcome scale of spreading technology and encouraging research. Article citation information is an important factor to determine the authority of the relevant author. Google Scholar uses the article citation information to organize academic article search results with a rank algorithm. For an accurate analysis of such important citation index information, large amounts of bibliographic data are required. Therefore, this study aims to build a fast and efficient system for large amounts of bibliographic data, and to design and develop a system for quickly analyzing cited information for that data. This study also aims to use and analyze citation data to be a basic element for providing various advanced services to the academic article search system.

  14. Sample preparation for large-scale bioanalytical studies based on liquid chromatographic techniques.

    Science.gov (United States)

    Medvedovici, Andrei; Bacalum, Elena; David, Victor

    2018-01-01

    Quality of the analytical data obtained for large-scale and long term bioanalytical studies based on liquid chromatography depends on a number of experimental factors including the choice of sample preparation method. This review discusses this tedious part of bioanalytical studies, applied to large-scale samples and using liquid chromatography coupled with different detector types as core analytical technique. The main sample preparation methods included in this paper are protein precipitation, liquid-liquid extraction, solid-phase extraction, derivatization and their versions. They are discussed by analytical performances, fields of applications, advantages and disadvantages. The cited literature covers mainly the analytical achievements during the last decade, although several previous papers became more valuable in time and they are included in this review. Copyright © 2017 John Wiley & Sons, Ltd.

  15. Studies on GEM modules for a large prototype TPC for the ILC

    International Nuclear Information System (INIS)

    Tsionou, Dimitra

    2016-12-01

    The International Linear Collider (ILC) is a future electron-positron collider with centre of mass energy of 500-1000 GeV. The International Large Detector (ILD) is one of two detector concepts at the ILC. Its high precision tracking system consists of Silicon sub-detectors and a Time Projection Chamber (TPC) equipped with micro-pattern gas detectors (MPGDs). Within the framework of the LCTPC collaboration, a Large Prototype (LP) TPC has been built as a demonstrator. This prototype has been equipped with Gas Electron Multiplier (GEM) modules and studied with electron beams of energies 1-6 GeV at the DESY test beam facility. The performance of the prototype detector and the extrapolation to the ILD TPC is presented here. In addition, ongoing optimisation studies and R and D; activities in order to prepare the next GEM module iteration are discussed.

  16. Studies on GEM modules for a Large Prototype TPC for the ILC

    Energy Technology Data Exchange (ETDEWEB)

    Tsionou, Dimitra, E-mail: dimitra.tsionou@desy.de

    2017-02-11

    The International Linear Collider (ILC) is a future electron–positron collider with centre of mass energy of 500–1000 GeV. The International Large Detector (ILD) is one of two detector concepts at the ILC. Its high precision tracking system consists of Silicon sub-detectors and a Time Projection Chamber (TPC) equipped with micro-pattern gas detectors (MPGDs). Within the framework of the LCTPC collaboration, a Large Prototype (LP) TPC has been built as a demonstrator. This prototype has been equipped with Gas Electron Multiplier (GEM) modules and studied with electron beams of energies 1–6 GeV at the DESY test beam facility. The performance of the prototype detector and the extrapolation to the ILD TPC is presented here. In addition, ongoing optimisation studies and R&D activities in order to prepare the next GEM module iteration are discussed.

  17. Numerical Studies of Electromagnetic Instabilities in Intense Charged Particle Beams with Large Energy Anisotropy

    CERN Document Server

    Startsev, Edward; Lee, Wei-li

    2005-01-01

    In intense charged particle beams with large energy anisotropy, free energy is available to drive transverse electromagnetic Weibel-type instabilities. Such slow-wave transverse electromagnetic instabilities can be described by the so-called Darwin model, which neglects the fast-wave portion of the displacement current. The Weibel instability may also lead to an increase in the longitudinal velocity spread, which would make the focusing of the beam difficult and impose a limit on the minimum spot size achievable in heavy ion fusion experiments. This paper reports the results of recent numerical studies of the Weibel instability using the Beam Eigenmode And Spectra (bEASt) code for space-charge-dominated, low-emittance beams with large tune depression. To study the nonlinear stage of the instability, the Darwin model is being developed and incorporated into the Beam Equilibrium Stability and Transport(BEST) code.

  18. Studies on GEM modules for a Large Prototype TPC for the ILC

    International Nuclear Information System (INIS)

    Tsionou, Dimitra

    2017-01-01

    The International Linear Collider (ILC) is a future electron–positron collider with centre of mass energy of 500–1000 GeV. The International Large Detector (ILD) is one of two detector concepts at the ILC. Its high precision tracking system consists of Silicon sub-detectors and a Time Projection Chamber (TPC) equipped with micro-pattern gas detectors (MPGDs). Within the framework of the LCTPC collaboration, a Large Prototype (LP) TPC has been built as a demonstrator. This prototype has been equipped with Gas Electron Multiplier (GEM) modules and studied with electron beams of energies 1–6 GeV at the DESY test beam facility. The performance of the prototype detector and the extrapolation to the ILD TPC is presented here. In addition, ongoing optimisation studies and R&D activities in order to prepare the next GEM module iteration are discussed.

  19. Acceptance of Driverless Vehicles: Results from a Large Cross-National Questionnaire Study

    OpenAIRE

    Nordhoff, Sina; de Winter, Joost; Kyriakidis, Miltos; van Arem, Bart; Happee, Riender

    2018-01-01

    Shuttles that operate without an onboard driver are currently being developed and tested in various projects worldwide. However, there is a paucity of knowledge on the determinants of acceptance of driverless shuttles in large cross-national samples. In the present study, we surveyed 10,000 respondents on the acceptance of driverless vehicles and sociodemographic characteristics, using a 94-item online questionnaire. After data filtering, data of 7,755 respondents from 116 countries were reta...

  20. Accident Investigation on a Large Construction Project: An Ethnographic Case Study

    OpenAIRE

    Oswald, David; Smith, Simon; Sherratt, Fred

    2015-01-01

    Unsafe acts are believed to account for approximately 80 to 90 percent of accidents. This paper will investigate this issue through exploring the reasoning behind the unsafe acts that resulted in a minor accident on a large construction project (+$1B) in the UK. The study described here, part of a wider PhD project, was undertaken using an ethnographic approach. Participant observation enabled the researcher to be involved in the whole accident investigation process including witness statemen...

  1. Nonlinear δf Simulation Studies of Intense Charged Particle Beams with Large Temperature Anisotropy

    International Nuclear Information System (INIS)

    Startsev, Edward A.; Davidson, Ronald C.; Qin, Hong

    2002-01-01

    In this paper, a 3-D nonlinear perturbative particle simulation code (BEST) [H. Qin, R.C. Davidson and W.W. Lee, Physical Review Special Topics on Accelerators and Beams 3 (2000) 084401] is used to systematically study the stability properties of intense nonneutral charged particle beams with large temperature anisotropy (T perpendicularb >> T parallelb ). The most unstable modes are identified, and their eigenfrequencies, radial mode structure, and nonlinear dynamics are determined for axisymmetric perturbations with ∂/∂θ = 0

  2. Study of a large Anglo-Saxon family with beta-thalassaemia trait.

    Science.gov (United States)

    Raik, E; Powell, E; Gordon, S

    1976-01-01

    Study of a large Anglo-Saxon family with beta-thalassaemia trait revealed evidence of consanguinity, moreover both branches of the family shared a Spanish ancestor. The manifestations of the disorder were varied in severity and yet the degree of severity appeared to breed true within any individual part of the family. Our explanation for the inheritance pattern observed in the family was to postulate the existence of two non-allelic genes influencing the rate of beta-chain synthesis.

  3. RACORO continental boundary layer cloud investigations: 1. Case study development and ensemble large-scale forcings

    Science.gov (United States)

    Vogelmann, Andrew M.; Fridlind, Ann M.; Toto, Tami; Endo, Satoshi; Lin, Wuyin; Wang, Jian; Feng, Sha; Zhang, Yunyan; Turner, David D.; Liu, Yangang; Li, Zhijin; Xie, Shaocheng; Ackerman, Andrew S.; Zhang, Minghua; Khairoutdinov, Marat

    2015-06-01

    Observation-based modeling case studies of continental boundary layer clouds have been developed to study cloudy boundary layers, aerosol influences upon them, and their representation in cloud- and global-scale models. Three 60 h case study periods span the temporal evolution of cumulus, stratiform, and drizzling boundary layer cloud systems, representing mixed and transitional states rather than idealized or canonical cases. Based on in situ measurements from the Routine AAF (Atmospheric Radiation Measurement (ARM) Aerial Facility) CLOWD (Clouds with Low Optical Water Depth) Optical Radiative Observations (RACORO) field campaign and remote sensing observations, the cases are designed with a modular configuration to simplify use in large-eddy simulations (LES) and single-column models. Aircraft measurements of aerosol number size distribution are fit to lognormal functions for concise representation in models. Values of the aerosol hygroscopicity parameter, κ, are derived from observations to be 0.10, which are lower than the 0.3 typical over continents and suggestive of a large aerosol organic fraction. Ensemble large-scale forcing data sets are derived from the ARM variational analysis, European Centre for Medium-Range Weather Forecasts, and a multiscale data assimilation system. The forcings are assessed through comparison of measured bulk atmospheric and cloud properties to those computed in "trial" large-eddy simulations, where more efficient run times are enabled through modest reductions in grid resolution and domain size compared to the full-sized LES grid. Simulations capture many of the general features observed, but the state-of-the-art forcings were limited at representing details of cloud onset, and tight gradients and high-resolution transients of importance. Methods for improving the initial conditions and forcings are discussed. The cases developed are available to the general modeling community for studying continental boundary clouds.

  4. RACORO Continental Boundary Layer Cloud Investigations: 1. Case Study Development and Ensemble Large-Scale Forcings

    Science.gov (United States)

    Vogelmann, Andrew M.; Fridlind, Ann M.; Toto, Tami; Endo, Satoshi; Lin, Wuyin; Wang, Jian; Feng, Sha; Zhang, Yunyan; Turner, David D.; Liu, Yangang; hide

    2015-01-01

    Observation-based modeling case studies of continental boundary layer clouds have been developed to study cloudy boundary layers, aerosol influences upon them, and their representation in cloud- and global-scale models. Three 60 h case study periods span the temporal evolution of cumulus, stratiform, and drizzling boundary layer cloud systems, representing mixed and transitional states rather than idealized or canonical cases. Based on in situ measurements from the Routine AAF (Atmospheric Radiation Measurement (ARM) Aerial Facility) CLOWD (Clouds with Low Optical Water Depth) Optical Radiative Observations (RACORO) field campaign and remote sensing observations, the cases are designed with a modular configuration to simplify use in large-eddy simulations (LES) and single-column models. Aircraft measurements of aerosol number size distribution are fit to lognormal functions for concise representation in models. Values of the aerosol hygroscopicity parameter, kappa, are derived from observations to be approximately 0.10, which are lower than the 0.3 typical over continents and suggestive of a large aerosol organic fraction. Ensemble large-scale forcing data sets are derived from the ARM variational analysis, European Centre for Medium-Range Weather Forecasts, and a multiscale data assimilation system. The forcings are assessed through comparison of measured bulk atmospheric and cloud properties to those computed in "trial" large-eddy simulations, where more efficient run times are enabled through modest reductions in grid resolution and domain size compared to the full-sized LES grid. Simulations capture many of the general features observed, but the state-of-the-art forcings were limited at representing details of cloud onset, and tight gradients and high-resolution transients of importance. Methods for improving the initial conditions and forcings are discussed. The cases developed are available to the general modeling community for studying continental boundary

  5. Study of nonpoint source nutrient loading in the Patuxent River basin, Maryland

    Science.gov (United States)

    Preston, S.D.

    1997-01-01

    Study of nonpoint-source (NPS) nutrient loading in Maryland has focused on the Patuxent watershed because of its importance and representativeness of conditions in the State. Evaluation of NPS nutrient loading has been comprehensive and has included long-term monitoring, detailed watershed modeling, and synoptic sampling studies. A large amount of information has been compiled for the watershed and that information is being used to identify primary controls and efficient management strategies for NPS nutrient loading. Results of the Patuxent NPS study have identified spatial trends in water quality that appear to be related to basin charcteristics such as land use, physiography, andgeology. Evaluation of the data compiled by the study components is continuing and is expected to provide more detailed assessments of the reasons for spatial trends. In particular, ongoing evaluation of the watershed model output is expected to provide detailed information on the relative importance of nutrient sources and transport pathways across the entire watershed. Planned future directions of NPS evaluation in the State of Maryland include continued study of water quality in the Patuxent watershed and a shift in emphasis to a statewide approach. Eventually, the statewide approach will become the primary approach usedby the State to evaluate NPS loading. The information gained in the Patuxent study and the tools developed will represent valuable assets indeveloping the statewide NPS assessment program.

  6. Pharmacy-based statewide naloxone distribution: A novel "top-down, bottom-up" approach.

    Science.gov (United States)

    Morton, Kate J; Harrand, Brianna; Floyd, Carly Cloud; Schaefer, Craig; Acosta, Julie; Logan, Bridget Claire; Clark, Karen

    To highlight New Mexico's multifaceted approach to widespread pharmacy naloxone distribution and to share the interventions as a tool for improving pharmacy-based naloxone practices in other states. New Mexico had the second highest drug overdose death rate in 2014 of which 53% were related to prescription opioids. Opioid overdose death is preventable through the use of naloxone, a safe and effective medication that reverses the effects of prescription opioids and heroin. Pharmacists can play an important role in providing naloxone to individuals who use prescription opioids. Not applicable. Not applicable. A multifaceted approach was utilized in New Mexico from the top down with legislative passage of provisions for a statewide standing order and New Mexico Department of Health support for pharmacy-based naloxone delivery. A bottom up approach was also initiated with the development and implementation of a training program for pharmacists and pharmacy technicians. Naloxone Medicaid claims were used to illustrate statewide distribution and utilization of the pharmacist statewide standing order for naloxone. Percent of pharmacies dispensing naloxone in each county were calculated. Trained pharmacy staff completed a program evaluation form. Questions about quality of instruction and ability of trainer to meet stated objectives were rated on a Likert scale. There were 808 naloxone Medicaid claims from 100 outpatient pharmacies during the first half of 2016, a 9-fold increase over 2014. The "A Dose of R x eality" training program evaluation indicated that participants felt the training was free from bias and met all stated objectives (4 out of 4 on Likert scale). A multi-pronged approach coupling state and community collaboration was successful in overcoming barriers and challenges associated with pharmacy naloxone distribution and ensured its success as an effective avenue for naloxone acquisition in urban and rural communities. Copyright © 2017 American Pharmacists

  7. Exertional Heat Illness among Secondary School Athletes: Statewide Policy Implications

    Science.gov (United States)

    Rodgers, Jill; Slota, Peggy; Zamboni, Beth

    2018-01-01

    Exertional heat illness (EHI) is a leading cause of preventable death among student athletes. While causes and preventative measures for EHI are known, school districts may not be implementing evidence-based practices. This descriptive, exploratory study explored school policies, resources, and practices of coaches in a mid-Atlantic state in the…

  8. Regionalism and Statewide Coordination of Postsecondary Education. Report No. 26.

    Science.gov (United States)

    Martorana, S. V.; McGuire, W. Gary

    Initial findings are reported of a continuing study of a new American postsecondary educational planning and coordination concept and its implementation: regionalism and regionalization. Regionalism is defined as that view of a geographic subsection of a state or of several adjoining states that considers all or a number of the postsecondary…

  9. Statewide planning scenario synthesis : transportation congestion measurement and management.

    Science.gov (United States)

    2005-09-01

    This study is a review of current practices in 13 states to: (1) measure traffic congestion and its costs; and (2) manage congestion with programs and techniques that do not involve the building of new highway capacity. In regard to the measures of c...

  10. Predictors of Suicidal Ideation in a Statewide Sample of Transgender Individuals.

    Science.gov (United States)

    Rood, Brian A; Puckett, Julia A; Pantalone, David W; Bradford, Judith B

    2015-09-01

    Transgender individuals experience violence and discrimination, which, in addition to gender transitioning, are established correlates of psychological distress. In a statewide sample of 350 transgender adults, we investigated whether a history of violence and discrimination increased the odds of reporting lifetime suicidal ideation (SI) and whether differences in SI were predicted by gender transition status. Violence, discrimination, and transition status significantly predicted SI. Compared with individuals with no plans to transition, individuals with plans or who were living as their identified gender reported greater odds of lifetime SI. We discuss implications for SI disparities using Meyer's minority stress model.

  11. Studies on reconstruction of large skin defects following mammary tumor excision in dogs

    Directory of Open Access Journals (Sweden)

    Sabarish Babu Malli Sadhasivan

    2017-12-01

    Full Text Available Aim: The main objective of the study was to describe the use of skin fold advancement flaps (SFAFs and other reconstructive techniques for closure of large skin defects following mammary tumor excision in dogs. Materials and Methods: Twelve dogs underwent reconstruction of large ventral skin defects following mammary tumor excision with wide margins. Skin fold flaps (flank fold flap and elbow fold flap were elevated from the flank and elbow region, respectively, and transposed and sutured onto the large ventral skin defect following mastectomy in all the dogs. In addition to the skin fold flaps, other reconstructive techniques such as undermining, walking sutures, and tension-relieving suture techniques were followed during surgery in the closure of large skin defects without skin tension and compromising limb mobility. The skin flap viability was assessed subjectively by gross observation of the flap such as color, temperature, capillary perfusion, and cosmetic appearance, and scoring (1-4 was done. Tissue samples were collected from a surgical site on days 3, 6, and 12 post-operatively for histopathological evaluation and healing status of the skin flap. Results: All the surgical wounds healed primarily, without any major complications and the skin flap remained healthy throughout the healing process post-operatively. Distal flap necrosis was noticed in one case and necrosis of skin flap between two suture lines was noticed in another case in which the necrotized distal portion healed by secondary intention after 7 days. The mean survival of subdermal plexus flap in the above cases was 98% which was a subjective evaluation based on surface area of the skin defect measured by Image 'J software and the flap dimensions. The average healing of skin flap in days was 14.91±0.86. Conclusion: The SFAFs along with other reconstructive techniques help in the reconstruction of large ventral skin defects following mastectomy in dogs without much

  12. Analysis of Large Genomic Data in Silico: The EPICNorfolk Study of Obesity

    DEFF Research Database (Denmark)

    Zhao, Jing Hua; Luan, Jian'an; Tan, Qihua

    In human genetics, large-scale data are now available with advances in genotyping technologies and international collaborative projects. Our ongoing study of obesity involves Affymetrix 500k genechips on approximately 7000 individuals from the European Prospective Investigation of Cancer (EPIC......) Norfolk study. Although the scale of our data is well beyond the ability of many software systems, we have successfully performed the analysis using the statistical analysis system (SAS) software. Our implementation trades memory with computing time and requires moderate hardware configuration. By using...

  13. Highlights of a recycling behaviour study in South Africa’s large urban areas

    CSIR Research Space (South Africa)

    Strydom, WF

    2012-10-01

    Full Text Available behaviour study in South Africa?s large urban areas WF STRYDOM CSIR Natural Resources and the Environment, PO Box 395, Pretoria 0001 Email: wstrydom@csir.co.za ? www.csir.co.za INTRODUCTION The recently promulgated National Environmental Management... representative sample of 2 004 respondents in 11 of the larger South African urban areas, including all the metropolitan municipalities. The survey was conducted in November 2010, before the Waste Act was widely implemented. The objective of the study was...

  14. Voltage uniformity study in large-area reactors for RF plasma deposition

    Energy Technology Data Exchange (ETDEWEB)

    Sansonnens, L.; Pletzer, A.; Magni, D.; Howling, A.A.; Hollenstein, C. [Ecole Polytechnique Federale, Lausanne (Switzerland). Centre de Recherche en Physique des Plasma (CRPP); Schmitt, J.P.M. [Balzers Process Systems, Palaiseau (France)

    1996-09-01

    Non-uniform voltage distribution across the electrode area results in inhomogeneous thin-film RF plasma deposition in large area reactors. In this work, a two-dimensional analytic model for the calculation of the voltage distribution across the electrode area is presented. The results of this model are in good agreement with measurements performed without plasma at 13.56 MHz and 70 MHz in a large area reactor. The principal voltage inhomogeneities are caused by logarithmic singularities in the vicinity of RF connections and not by standing waves. These singularities are only described by a two-dimensional model and cannot be intuitively predicted by analogy to a one-dimensional case. Plasma light emission measurements and thickness homogeneity studies of a-Si:H films show that the plasma reproduces these voltage inhomogeneities. Improvement of the voltage uniformity is investigated by changing the number and position of the RF connections. (author) 13 figs., 20 refs.

  15. `Not hard to sway': a case study of student engagement in two large engineering classes

    Science.gov (United States)

    Shekhar, Prateek; Borrego, Maura

    2018-07-01

    Although engineering education research has empirically validated the effectiveness of active learning in improving student learning over traditional lecture-based methods, the adoption of active learning in classrooms has been slow. One of the greatest reported barriers is student resistance towards engagement in active learning exercises. This paper argues that the level of student engagement in active learning classrooms is an interplay of social and physical classroom characteristics. Using classroom observations and instructor interviews, this study describes the influence of the interaction of student response systems and classroom layout on student engagement in two large active-learning-based engineering classrooms. The findings suggest that the use of different student response systems in combination with cluster-style seating arrangements can increase student engagement in large classrooms.

  16. A mesh density study for application to large deformation rolling process evaluation

    International Nuclear Information System (INIS)

    Martin, J.A.

    1997-12-01

    When addressing large deformation through an elastic-plastic analysis the mesh density is paramount in determining the accuracy of the solution. However, given the nonlinear nature of the problem, a highly-refined mesh will generally require a prohibitive amount of computer resources. This paper addresses finite element mesh optimization studies considering accuracy of results and computer resource needs as applied to large deformation rolling processes. In particular, the simulation of the thread rolling manufacturing process is considered using the MARC software package and a Cray C90 supercomputer. Both mesh density and adaptive meshing on final results for both indentation of a rigid body to a specified depth and contact rolling along a predetermined length are evaluated

  17. Drastic Pressure Effect on the Extremely Large Magnetoresistance in WTe2: Quantum Oscillation Study.

    Science.gov (United States)

    Cai, P L; Hu, J; He, L P; Pan, J; Hong, X C; Zhang, Z; Zhang, J; Wei, J; Mao, Z Q; Li, S Y

    2015-07-31

    The quantum oscillations of the magnetoresistance under ambient and high pressure have been studied for WTe2 single crystals, in which extremely large magnetoresistance was discovered recently. By analyzing the Shubnikov-de Haas oscillations, four Fermi surfaces are identified, and two of them are found to persist to high pressure. The sizes of these two pockets are comparable, but show increasing difference with pressure. At 0.3 K and in 14.5 T, the magnetoresistance decreases drastically from 1.25×10(5)% under ambient pressure to 7.47×10(3)% under 23.6 kbar, which is likely caused by the relative change of Fermi surfaces. These results support the scenario that the perfect balance between the electron and hole populations is the origin of the extremely large magnetoresistance in WTe2.

  18. Studies on combined model based on functional objectives of large scale complex engineering

    Science.gov (United States)

    Yuting, Wang; Jingchun, Feng; Jiabao, Sun

    2018-03-01

    As various functions were included in large scale complex engineering, and each function would be conducted with completion of one or more projects, combined projects affecting their functions should be located. Based on the types of project portfolio, the relationship of projects and their functional objectives were analyzed. On that premise, portfolio projects-technics based on their functional objectives were introduced, then we studied and raised the principles of portfolio projects-technics based on the functional objectives of projects. In addition, The processes of combined projects were also constructed. With the help of portfolio projects-technics based on the functional objectives of projects, our research findings laid a good foundation for management of large scale complex engineering portfolio management.

  19. Transitions in pregnancy planning in women recruited for a large prospective cohort study.

    Science.gov (United States)

    Luderer, U; Li, T; Fine, J P; Hamman, R F; Stanford, J B; Baker, D

    2017-06-01

    Do the rates at which women transition among different intensities of pregnancy planning vary with age, marital status and race/ethnicity? Rates of transition from low or moderate pregnancy probability groups (PPGs) to higher PPGs vary by age, marital status and race/ethnicity. The design of prospective studies of the effects of pre- and peri-conception exposures on fecundity, pregnancy and children's health is challenging because at any specific time only a small percentage of reproductive age women is attempting to conceive. To our knowledge, there has been no population-based, prospective study that repeatedly assessed pregnancy planning, which included women who were not already planning pregnancy at enrollment and whose ages spanned the female reproductive age range. A longitudinal study was carried out that repeatedly assessed pregnancy probability in 12 916 women for up to 21 months from January 2009 to September 2010. We analyzed data from the National Children's Study Vanguard Study, a pilot study for a large-scale epidemiological birth cohort study of children and their parents. During the Vanguard Study, investigators followed population-based samples of reproductive age women in each of seven geographically dispersed and diverse study locations over time to identify when they sought to become pregnant, providing a unique opportunity to prospectively assess changes in pregnancy planning in a large sample of US women. At study entry and each follow-up contact, which occurred at 1, 3 or 6 month intervals depending on PPG, a questionnaire was used to assess behavior dimensions of pregnancy planning to assign women to low, moderate, high non-tryer and high tryer PPGs. Crude rates of pregnancy increased with higher assigned PPG, validating the utility of the instrument. The initial PPG and probabilities of transitioning from low or moderate PPG to higher PPG or pregnancy varied with age, marital status and race/ethnicity. Women aged 25 to planning behavior in

  20. Investigating the large degeneracy Kondo lattice metamagnet CeTiGe: Crystal growth and doping studies

    Energy Technology Data Exchange (ETDEWEB)

    Gruner, T.; Caroca-Canales, N.; Deppe, M.; Geibel, C. [MPI fuer Chemische Physik fester Stoffe, 01187, Dresden (Germany); Sereni, J. [Centro Atomico Bariloche, 8400, S. C. de Bariloche (Argentina)

    2011-07-01

    CeTiGe is a paramagnetic Kondo lattice system with a large orbital degeneracy involved in the formation of the heavy Fermion ground state. Recently we discovered that this compound presents a huge metamagnetic transition at B{sub MMT} {approx} 13 T, with much larger anomalies in magnetization, magnetoresistance and magnetostriction than in the archetypical Kondo lattice metamagnet CeRu{sub 2}Si{sub 2}. Since CeTiGe forms in a pronounced peritectic reaction the growth of single crystals is difficult. We therefore studied the Ce-Ti-Ge ternary metallographic phase diagram to get a sound basis for future crystal growth attempts. Preliminary results of growth experiments based on these studies are promising and shall be discussed. Furthermore, Ti-rich CeTiGe was recently reported to present a high temperature phase crystallizing in the closely related CeScSi structure type. In order to study this structural instability and the effect on the physical properties, we studied the effect of substituting Sc for Ti, since pure CeScGe crystallizes in the CeScSi structure type. In well annealed samples we observed a two phase region in the range 10% - 25%-Sc-substitution. Preliminary investigations of the CeSc{sub x}Ti{sub 1-x}Ge alloy suggest it is a promising candidate for the observation of a ferromagnetic quantum critical point in a large degeneracy Kondo lattice system.

  1. IMPACTS OF OWN BRANDS STRATEGY ON MANUFACTURER – RETAILER RELATIONSHIP: CASE STUDIES IN LARGE SIZE COMPANIES

    Directory of Open Access Journals (Sweden)

    Renato Telles

    2012-05-01

    Full Text Available The study of marketing and production strategy of own brand products requires an understanding of both the benefits gained by retailers and manufacturers involved in this activity and also the effects of this strategy on the relationship between these companies. According to this idea, a qualitative and descriptive work was conducted, based on six case studies, three of them on large product manufacturers and three on large retailers. The aim of this study is defined is threefold: (1 to analyze the expectations of manufacturers and retailers with their own brands’ current operations, (2 to analyze the expectations of manufacturers and retailers with their own brands’ future operations, and (3 to analyze the influence of the own brands adoption on the relationship between manufacturers and retailers. The results indicate that (a current operations are primarily based on economic reasons (market share, and use of spare capacity, (b future operations are perceived from a marketing perspective (survival, and (c the adoption of own brand strategy does not harm the relationship between the parties – both manufacturers and retailers –, unlike the earlier studies indicated.

  2. Dam risk reduction study for a number of large tailings dams in Ontario

    Energy Technology Data Exchange (ETDEWEB)

    Verma, N. [AMEC Earth and Environmental Ltd., Mississauga, ON (Canada); Small, A. [AMEC Earth and Environmental Ltd., Fredericton, NB (Canada); Martin, T. [AMEC Earth and Environmental, Burnaby, BC (Canada); Cacciotti, D. [AMEC Earth and Environmental Ltd., Sudbury, ON (Canada); Ross, T. [Vale Inco Ltd., Sudbury, ON (Canada)

    2009-07-01

    This paper discussed a risk reduction study conducted for 10 large tailings dams located at a central tailings facility in Ontario. Located near large industrial and urban developments, the tailings dams were built using an upstream method of construction that did not involve beach compaction or the provision of under-drainage. The study provided a historical background for the dam and presented results from investigations and instrumentation data. The methods used to develop the dam configurations were discussed, and remedial measures and risk assessment measures used on the dams were reviewed. The aim of the study was to address key sources of risk, which include the presence of high pore pressures and hydraulic gradients; the potential for liquefaction; slope instability; and the potential for overtopping. A borehole investigation was conducted and piezocone probes were used to obtain continuous data and determine soil and groundwater conditions. The study identified that the lower portion of the dam slopes were of concern. Erosion gullies could lead to larger scale failures, and elevated pore pressures could lead to the risk of seepage breakouts. It was concluded that remedial measures are now being conducted to ensure slope stability. 6 refs., 1 tab., 6 figs.

  3. Pilot Study of Topical Copper Chlorophyllin Complex in Subjects With Facial Acne and Large Pores.

    Science.gov (United States)

    Stephens, Thomas J; McCook, John P; Herndon, James H

    2015-06-01

    Acne vulgaris is one of the most common skin diseases treated by dermatologists. Salts of copper chlorophyllin complex are semi-synthetic naturally-derived compounds with antioxidant, anti-inflammatory and wound healing activity that have not been previously tested topically in the treatment of acne-prone skin with enlarged pores. This single-center pilot study was conducted to assess the efficacy and safety of a liposomal dispersion of topically applied sodium copper chlorophyllin complex in subjects with mild-moderate acne and large, visible pores over a course of 3 weeks. Subjects were supplied with the test product, a topical gel containing a liposomal dispersion of sodium copper chlorophyllin complex (0.1%) with directions to apply a small amount to the facial area twice daily. Clinical assessments were performed at screening/baseline and at week 3. VISIA readings were taken and self-assessment questionnaires were conducted. 10 subjects were enrolled and completed the 3-week study. All clinical efficacy parameters showed statistically significant improvements over baseline at week 3. The study product was well tolerated. Subject questionnaires showed the test product was highly rated. In this pilot study, a topical formulation containing a liposomal dispersion of sodium copper chlorophyllin complex was shown to be clinically effective and well tolerated for the treatment of mild-moderate acne and large, visible pores when used for 3 weeks.

  4. Software engineering the mixed model for genome-wide association studies on large samples.

    Science.gov (United States)

    Zhang, Zhiwu; Buckler, Edward S; Casstevens, Terry M; Bradbury, Peter J

    2009-11-01

    Mixed models improve the ability to detect phenotype-genotype associations in the presence of population stratification and multiple levels of relatedness in genome-wide association studies (GWAS), but for large data sets the resource consumption becomes impractical. At the same time, the sample size and number of markers used for GWAS is increasing dramatically, resulting in greater statistical power to detect those associations. The use of mixed models with increasingly large data sets depends on the availability of software for analyzing those models. While multiple software packages implement the mixed model method, no single package provides the best combination of fast computation, ability to handle large samples, flexible modeling and ease of use. Key elements of association analysis with mixed models are reviewed, including modeling phenotype-genotype associations using mixed models, population stratification, kinship and its estimation, variance component estimation, use of best linear unbiased predictors or residuals in place of raw phenotype, improving efficiency and software-user interaction. The available software packages are evaluated, and suggestions made for future software development.

  5. Study of high muon multiplicity cosmic ray events with ALICE at the CERN Large Hadron Collider

    CERN Document Server

    Rodriguez Cahuantzi, Mario

    2015-01-01

    ALICE is one of four large experiments at the CERN Large Hadron Collider. Located 52 meters undergroundwith 28meters of overburden rock, it has also been used to detect atmosphericmuons produced by cosmic-ray interactions in the upper atmosphere. We present the muon multiplicity distribution of these cosmic-ray events and their comparison with Monte Carlo simulation. This analysis exploits the large size and excellent tracking capability of the ALICE Time Projection Chamber. A special emphasis is given to the study of high multiplicity events containing more than 100 reconstructed muons and corresponding to a muon areal density larger than 5.9 m$^{−2}$. The measured rate of these events shows that they stem from primary cosmic-rays with energies above 10$^{16}$ eV. The frequency of these events can be successfully described by assuming a heavy mass composition of primary cosmic-rays in this energy range and using the most recent hadronic interaction models to simulate the development of the resulting air sh...

  6. Performance of informative priors skeptical of large treatment effects in clinical trials: A simulation study.

    Science.gov (United States)

    Pedroza, Claudia; Han, Weilu; Thanh Truong, Van Thi; Green, Charles; Tyson, Jon E

    2018-01-01

    One of the main advantages of Bayesian analyses of clinical trials is their ability to formally incorporate skepticism about large treatment effects through the use of informative priors. We conducted a simulation study to assess the performance of informative normal, Student- t, and beta distributions in estimating relative risk (RR) or odds ratio (OR) for binary outcomes. Simulation scenarios varied the prior standard deviation (SD; level of skepticism of large treatment effects), outcome rate in the control group, true treatment effect, and sample size. We compared the priors with regards to bias, mean squared error (MSE), and coverage of 95% credible intervals. Simulation results show that the prior SD influenced the posterior to a greater degree than the particular distributional form of the prior. For RR, priors with a 95% interval of 0.50-2.0 performed well in terms of bias, MSE, and coverage under most scenarios. For OR, priors with a wider 95% interval of 0.23-4.35 had good performance. We recommend the use of informative priors that exclude implausibly large treatment effects in analyses of clinical trials, particularly for major outcomes such as mortality.

  7. Femtosecond time-resolved studies of coherent vibrational Raman scattering in large gas-phase molecules

    International Nuclear Information System (INIS)

    Hayden, C.C.; Chandler, D.W.

    1995-01-01

    Results are presented from femtosecond time-resolved coherent Raman experiments in which we excite and monitor vibrational coherence in gas-phase samples of benzene and 1,3,5-hexatriene. Different physical mechanisms for coherence decay are seen in these two molecules. In benzene, where the Raman polarizability is largely isotropic, the Q branch of the vibrational Raman spectrum is the primary feature excited. Molecules in different rotational states have different Q-branch transition frequencies due to vibration--rotation interaction. Thus, the macroscopic polarization that is observed in these experiments decays because it has many frequency components from molecules in different rotational states, and these frequency components go out of phase with each other. In 1,3,5-hexatriene, the Raman excitation produces molecules in a coherent superposition of rotational states, through (O, P, R, and S branch) transitions that are strong due to the large anisotropy of the Raman polarizability. The coherent superposition of rotational states corresponds to initially spatially oriented, vibrationally excited, molecules that are freely rotating. The rotation of molecules away from the initial orientation is primarily responsible for the coherence decay in this case. These experiments produce large (∼10% efficiency) Raman shifted signals with modest excitation pulse energies (10 μJ) demonstrating the feasibility of this approach for a variety of gas phase studies. copyright 1995 American Institute of Physics

  8. Evaluation of Kirkwood-Buff integrals via finite size scaling: a large scale molecular dynamics study

    Science.gov (United States)

    Dednam, W.; Botha, A. E.

    2015-01-01

    Solvation of bio-molecules in water is severely affected by the presence of co-solvent within the hydration shell of the solute structure. Furthermore, since solute molecules can range from small molecules, such as methane, to very large protein structures, it is imperative to understand the detailed structure-function relationship on the microscopic level. For example, it is useful know the conformational transitions that occur in protein structures. Although such an understanding can be obtained through large-scale molecular dynamic simulations, it is often the case that such simulations would require excessively large simulation times. In this context, Kirkwood-Buff theory, which connects the microscopic pair-wise molecular distributions to global thermodynamic properties, together with the recently developed technique, called finite size scaling, may provide a better method to reduce system sizes, and hence also the computational times. In this paper, we present molecular dynamics trial simulations of biologically relevant low-concentration solvents, solvated by aqueous co-solvent solutions. In particular we compare two different methods of calculating the relevant Kirkwood-Buff integrals. The first (traditional) method computes running integrals over the radial distribution functions, which must be obtained from large system-size NVT or NpT simulations. The second, newer method, employs finite size scaling to obtain the Kirkwood-Buff integrals directly by counting the particle number fluctuations in small, open sub-volumes embedded within a larger reservoir that can be well approximated by a much smaller simulation cell. In agreement with previous studies, which made a similar comparison for aqueous co-solvent solutions, without the additional solvent, we conclude that the finite size scaling method is also applicable to the present case, since it can produce computationally more efficient results which are equivalent to the more costly radial distribution

  9. Evaluation of Kirkwood-Buff integrals via finite size scaling: a large scale molecular dynamics study

    International Nuclear Information System (INIS)

    Dednam, W; Botha, A E

    2015-01-01

    Solvation of bio-molecules in water is severely affected by the presence of co-solvent within the hydration shell of the solute structure. Furthermore, since solute molecules can range from small molecules, such as methane, to very large protein structures, it is imperative to understand the detailed structure-function relationship on the microscopic level. For example, it is useful know the conformational transitions that occur in protein structures. Although such an understanding can be obtained through large-scale molecular dynamic simulations, it is often the case that such simulations would require excessively large simulation times. In this context, Kirkwood-Buff theory, which connects the microscopic pair-wise molecular distributions to global thermodynamic properties, together with the recently developed technique, called finite size scaling, may provide a better method to reduce system sizes, and hence also the computational times. In this paper, we present molecular dynamics trial simulations of biologically relevant low-concentration solvents, solvated by aqueous co-solvent solutions. In particular we compare two different methods of calculating the relevant Kirkwood-Buff integrals. The first (traditional) method computes running integrals over the radial distribution functions, which must be obtained from large system-size NVT or NpT simulations. The second, newer method, employs finite size scaling to obtain the Kirkwood-Buff integrals directly by counting the particle number fluctuations in small, open sub-volumes embedded within a larger reservoir that can be well approximated by a much smaller simulation cell. In agreement with previous studies, which made a similar comparison for aqueous co-solvent solutions, without the additional solvent, we conclude that the finite size scaling method is also applicable to the present case, since it can produce computationally more efficient results which are equivalent to the more costly radial distribution

  10. Evaluating GPS biologging technology for studying spatial ecology of large constricting snakes

    Science.gov (United States)

    Smith, Brian; Hart, Kristen M.; Mazzotti, Frank J.; Basille, Mathieu; Romagosa, Christina M.

    2018-01-01

    Background: GPS telemetry has revolutionized the study of animal spatial ecology in the last two decades. Until recently, it has mainly been deployed on large mammals and birds, but the technology is rapidly becoming miniaturized, and applications in diverse taxa are becoming possible. Large constricting snakes are top predators in their ecosystems, and accordingly they are often a management priority, whether their populations are threatened or invasive. Fine-scale GPS tracking datasets could greatly improve our ability to understand and manage these snakes, but the ability of this new technology to deliver high-quality data in this system is unproven. In order to evaluate GPS technology in large constrictors, we GPS-tagged 13 Burmese pythons (Python bivittatus) in Everglades National Park and deployed an additional 7 GPS tags on stationary platforms to evaluate habitat-driven biases in GPS locations. Both python and test platform GPS tags were programmed to attempt a GPS fix every 90 min.Results: While overall fix rates for the tagged pythons were low (18.1%), we were still able to obtain an average of 14.5 locations/animal/week, a large improvement over once-weekly VHF tracking. We found overall accuracy and precision to be very good (mean accuracy = 7.3 m, mean precision = 12.9 m), but a very few imprecise locations were still recorded (0.2% of locations with precision > 1.0 km). We found that dense vegetation did decrease fix rate, but we concluded that the low observed fix rate was also due to python microhabitat selection underground or underwater. Half of our recovered pythons were either missing their tag or the tag had malfunctioned, resulting in no data being recovered.Conclusions: GPS biologging technology is a promising tool for obtaining frequent, accurate, and precise locations of large constricting snakes. We recommend future studies couple GPS telemetry with frequent VHF locations in order to reduce bias and limit the impact of catastrophic

  11. Leveraging a Statewide Clinical Data Warehouse to Expand Boundaries of the Learning Health System.

    Science.gov (United States)

    Turley, Christine B; Obeid, Jihad; Larsen, Rick; Fryar, Katrina M; Lenert, Leslie; Bjorn, Arik; Lyons, Genevieve; Moskowitz, Jay; Sanderson, Iain

    2016-01-01

    Learning Health Systems (LHS) require accessible, usable health data and a culture of collaboration-a challenge for any single system, let alone disparate organizations, with macro- and micro-systems. Recently, the National Science Foundation described this important setting as a cyber-social ecosystem. In 2004, in an effort to create a platform for transforming health in South Carolina, Health Sciences South Carolina (HSSC) was established as a research collaboration of the largest health systems, academic medical centers and research intensive universities in South Carolina. With work beginning in 2010, HSSC unveiled an integrated Clinical Data Warehouse (CDW) in 2013 as a crucial anchor to a statewide LHS. This CDW integrates data from independent health systems in near-real time, and harmonizes the data for aggregation and use in research. With records from over 2.7 million unique patients spanning 9 years, this multi-institutional statewide clinical research repository allows integrated individualized patient-level data to be used for multiple population health and biomedical research purposes. In the first 21 months of operation, more than 2,800 de-identified queries occurred through i2b2, with 116 users. HSSC has developed and implemented solutions to complex issues emphasizing anti-competitiveness and participatory governance, and serves as a recognized model to organizations working to improve healthcare quality by extending the traditional borders of learning health systems.

  12. Avoiding a knowledge gap in a multiethnic statewide social marketing campaign: is cultural tailoring sufficient?

    Science.gov (United States)

    Buchthal, O Vanessa; Doff, Amy L; Hsu, Laura A; Silbanuz, Alice; Heinrich, Katie M; Maddock, Jay E

    2011-03-01

    In 2007, the State of Hawaii, Healthy Hawaii Initiative conducted a statewide social-marketing campaign promoting increased physical activity and nutrition. The campaign included substantial formative research to develop messages tailored for Hawaii's multiethnic Asian and Pacific Islander populations. The authors conducted a statewide random digital dialing telephone survey to assess the campaign's comparative reach among individuals with different ethnicities and different levels of education and income. This analysis suggests that the intervention was successful in reaching its target ethnic audiences. However, a knowledge gap related to the campaign appeared among individuals with incomes less than 130% of the poverty level and those with less than a high school education. These results varied significantly by message and the communication channel used. Recall of supermarket-based messages was significantly higher among individuals below 130% of the poverty level and those between 18 and 35 years of age, 2 groups that showed consistently lower recall of messages in other channels. Results suggest that cultural tailoring for ethnic audiences, although important, is insufficient for reaching low-income populations, and that broad-based social marketing campaigns should consider addressing socioeconomic status-related channel preferences in formative research and campaign design.

  13. Technical architecture of ONC-approved plans for statewide health information exchange.

    Science.gov (United States)

    Barrows, Randolph C; Ezzard, John

    2011-01-01

    ONC-approved state plans for HIE were reviewed for descriptions and depictions of statewide HIE technical architecture. Review was complicated by non-standard organizational elements and technical terminology across state plans. Findings were mapped to industry standard, referenced, and defined HIE architecture descriptions and characteristics. Results are preliminary due to the initial subset of ONC-approved plans available, the rapid pace of new ONC-plan approvals, and continuing advancements in standards and technology of HIE, etc. Review of 28 state plans shows virtually all include a direct messaging component, but for participating entities at state-specific levels of granularity (RHIO, enterprise, organization/provider). About ½ of reviewed plans describe a federated architecture, and ¼ of plans utilize a single-vendor "hybrid-federated" architecture. About 1/3 of states plan to leverage new federal and open exchange technologies (DIRECT, CONNECT, etc.). Only one plan describes a centralized architecture for statewide HIE, but others combine central and federated architectural approaches.

  14. Relay chatter and operator response after a large earthquake: An improved PRA methodology with case studies

    International Nuclear Information System (INIS)

    Budnitz, R.J.; Lambert, H.E.; Hill, E.E.

    1987-08-01

    The purpose of this project has been to develop and demonstrate improvements in the PRA methodology used for analyzing earthquake-induced accidents at nuclear power reactors. Specifically, the project addresses methodological weaknesses in the PRA systems analysis used for studying post-earthquake relay chatter and for quantifying human response under high stress. An improved PRA methodology for relay-chatter analysis is developed, and its use is demonstrated through analysis of the Zion-1 and LaSalle-2 reactors as case studies. This demonstration analysis is intended to show that the methodology can be applied in actual cases, and the numerical values of core-damage frequency are not realistic. The analysis relies on SSMRP-based methodologies and data bases. For both Zion-1 and LaSalle-2, assuming that loss of offsite power (LOSP) occurs after a large earthquake and that there are no operator recovery actions, the analysis finds very many combinations (Boolean minimal cut sets) involving chatter of three or four relays and/or pressure switch contacts. The analysis finds that the number of min-cut-set combinations is so large that there is a very high likelihood (of the order of unity) that at least one combination will occur after earthquake-caused LOSP. This conclusion depends in detail on the fragility curves and response assumptions used for chatter. Core-damage frequencies are calculated, but they are probably pessimistic because assuming zero credit for operator recovery is pessimistic. The project has also developed an improved PRA methodology for quantifying operator error under high-stress conditions such as after a large earthquake. Single-operator and multiple-operator error rates are developed, and a case study involving an 8-step procedure (establishing feed-and-bleed in a PWR after an earthquake-initiated accident) is used to demonstrate the methodology

  15. CLINICOPATHOLOGICAL STUDY AND MANAGEMENT OF LARGE GUT VOLVULUS WITH REFERENCE TO PRIMARY RESECTION AND ANASTOMOSIS

    Directory of Open Access Journals (Sweden)

    Siba Prasad Dash

    2017-11-01

    Full Text Available BACKGROUND Large gut volvulus is a common surgical emergency in many regions of the world with significant morbidity and mortality. Delay in the diagnosis and treatment can lead to serious complications such as like bowel gangrene, perforation, peritonitis and sepsis. Emergency operation is needed in acute large gut volvulus. The purpose of our study was to analyse the mode of presentations and evaluate the outcome of various methods used in surgical management with reference to primary resection and anastomosis of large gut volvulus, mainly sigmoid volvulus, as it is the commonest type encountered. MATERIALS AND METHODS This study was conducted in 52 patients with acute sigmoid volvulus randomly out of 214 cases of intestinal obstruction admitted to M.K.C.G. Medical College in the Department of General Surgery from July 2015 to June 2017. Laparotomy were carried out in all 52 patients, primary resection of the affected sigmoid colon with anastomosis in single layer (n=21 and double layer (n=31 were done. Outcome of the two procedures analysed in terms of mortality, postoperative complications and hospital stay. RESULTS The maximum number of cases were found in between 41 to 60 years of age and male-to-female ratio was 2.7:1. Distention of abdomen (96% followed by constipation in 90% were common mode of presentation. Postoperative mortality rate of 6%. Common postoperative complication found to be wound infections and a chest infection. It was 27% and 25%, respectively. Mortality and morbidity associated with single layer anastomosis was lower (14.29% compared with conventional double layer technique (22.58%. CONCLUSION This study demonstrated that resection and anastomosis should be done in acute sigmoid volvulus safely. Single layer extra mucosal technique is safe and desirable in clinical practice with significant advantages than standard two layer technique.

  16. Beyond the Usability Lab Conducting Large-scale Online User Experience Studies

    CERN Document Server

    Albert, William; Tullis, Thomas

    2010-01-01

    Usability testing and user experience research typically take place in a controlled lab with small groups. While this type of testing is essential to user experience design, more companies are also looking to test large sample sizes to be able compare data according to specific user populations and see how their experiences differ across user groups. But few usability professionals have experience in setting up these studies, analyzing the data, and presenting it in effective ways.  Online usability testing offers the solution by allowing testers to elicit feedback simultaneously from 1,0

  17. All polymer chip for amperometric studies of transmitter release from large groups of neuronal cells

    DEFF Research Database (Denmark)

    Larsen, Simon T.; Taboryski, Rafael

    2012-01-01

    We present an all polymer electrochemical chip for simple detection of transmitter release from large groups of cultured PC 12 cells. Conductive polymer PEDOT:tosylate microelectrodes were used together with constant potential amperometry to obtain easy-to-analyze oxidation signals from potassium......-induced release of transmitter molecules. The nature of the resulting current peaks is discussed, and the time for restoring transmitter reservoirs is studied. The relationship between released transmitters and potassium concentration was found to fit to a sigmoidal dose–response curve. Finally, we demonstrate...

  18. Study on external reactor vessel cooling capacity for advanced large size PWR

    International Nuclear Information System (INIS)

    Jin Di; Liu Xiaojing; Cheng Xu; Li Fei

    2014-01-01

    External reactor vessel cooling (ERVC) is widely adopted as a part of in- vessel retention (IVR) in severe accident management strategies. In this paper, some flow parameters and boundary conditions, eg., inlet and outlet area, water inlet temperature, heating power of the lower head, the annular gap size at the position of the lower head and flooding water level, were considered to qualitatively study the effect of them on natural circulation capacity of the external reactor vessel cooling for an advanced large size PWR by using RELAP5 code. And the calculation results provide some basis of analysis for the structure design and the following transient response behavior of the system. (authors)

  19. New Insights about Enzyme Evolution from Large Scale Studies of Sequence and Structure Relationships*

    Science.gov (United States)

    Brown, Shoshana D.; Babbitt, Patricia C.

    2014-01-01

    Understanding how enzymes have evolved offers clues about their structure-function relationships and mechanisms. Here, we describe evolution of functionally diverse enzyme superfamilies, each representing a large set of sequences that evolved from a common ancestor and that retain conserved features of their structures and active sites. Using several examples, we describe the different structural strategies nature has used to evolve new reaction and substrate specificities in each unique superfamily. The results provide insight about enzyme evolution that is not easily obtained from studies of one or only a few enzymes. PMID:25210038

  20. New insights about enzyme evolution from large scale studies of sequence and structure relationships.

    Science.gov (United States)

    Brown, Shoshana D; Babbitt, Patricia C

    2014-10-31

    Understanding how enzymes have evolved offers clues about their structure-function relationships and mechanisms. Here, we describe evolution of functionally diverse enzyme superfamilies, each representing a large set of sequences that evolved from a common ancestor and that retain conserved features of their structures and active sites. Using several examples, we describe the different structural strategies nature has used to evolve new reaction and substrate specificities in each unique superfamily. The results provide insight about enzyme evolution that is not easily obtained from studies of one or only a few enzymes. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

  1. Ballistic deficit correction methods for large Ge detectors-high counting rate study

    International Nuclear Information System (INIS)

    Duchene, G.; Moszynski, M.

    1995-01-01

    This study presents different ballistic correction methods versus input count rate (from 3 to 50 kcounts/s) using four large Ge detectors of about 70 % relative efficiency. It turns out that the Tennelec TC245 linear amplifier in the BDC mode (Hinshaw method) is the best compromise for energy resolution throughout. All correction methods lead to narrow sum-peaks indistinguishable from single Γ lines. The full energy peak throughput is found representative of the pile-up inspection dead time of the corrector circuits. This work also presents a new and simple representation, plotting simultaneously energy resolution and throughput versus input count rate. (TEC). 12 refs., 11 figs

  2. CSCW Challenges in Large-Scale Technical Projects - a case study

    DEFF Research Database (Denmark)

    Grønbæk, Kaj; Kyng, Morten; Mogensen, Preben Holst

    1992-01-01

    This paper investigates CSCW aspects of large-scale technical projects based on a case study of a specific Danish engineering company and uncovers s challenges to CSCW applications in this setting. The company is responsible for management and supervision of one of the worlds largest tunnel....... The initial qualitative analysis identified a number of bottlenecks in daily work, where support for cooperation is needed. Examples of bottlenecks are: sharing materials, issuing tasks, and keeping track of task status. Grounded in the analysis, cooperative design workshops based on scenarios of future work...

  3. Study on zigzag maneuver characteristics of V-U very large crude oil (VLCC) tankers

    Science.gov (United States)

    Jaswar, Maimun, A.; Wahid, M. A.; Priyanto, A.; Zamani, Pauzi, Saman

    2012-06-01

    The Department of Marine Technology at the Faculty of Mechanical Engineering, University Teknologi Malaysia has recently developed an Ship Maneuverability tool which intends to upgrade student's level understanding the application of fluid dynamic on interaction between hull, propeller, and rudder during maneuvering. This paper discusses zigzag maneuver for conventional Very Large Crude Oil (VLCC) ships with the same principal dimensions but different stern flame shape. 10/10 zigzag maneuver characteristics of U and V types of VLCC ships are investigated. Simulation results for U-type show a good agreement with the experimental data, but V-type not good agreement with experimental one. Further study on zigzag maneuver characteristics are required.

  4. Hypothyroidism in Patients with Psoriasis or Rosacea: A Large Population Study.

    Science.gov (United States)

    James, Sara M; Hill, Dane E; Feldman, Steven R

    2016-10-15

    Hypothyroidism is a common disease, and there may be a link between hypothyroidism and inflammatory skin disease. The purpose of this study is to assess whether hypothyroidism is more prevalent in psoriasis or rosacea patients. We utilized a large claims-based database to analyze rates of hypothyroidism in patients with psoriasis and rosacea compared to other patients with skin diseases. Participants were patients between 20-64 years of age with ICD-9 diagnosis codes for psoriasis, rosacea, and hypothyroidism. We found that rates of hypothyroidism in rosacea and psoriasis patients were similar to rates of hypothyroidism in those without rosacea or psoriasis.

  5. Study on the performance of large area MRPC with high position resolution

    Energy Technology Data Exchange (ETDEWEB)

    Yue Qian, E-mail: yueq@mail.tsinghua.edu.cn [Department of Engineering Physics, Tsinghua University, Beijing 100084 (China); Key Laboratory of Particle and Radiation Imaging, Tsinghua University, Ministry of Education (China); Wu Yucheng; Li Yuanjing; Ye Jin; Cheng Jianping; Wang Yi; Li Jin [Department of Engineering Physics, Tsinghua University, Beijing 100084 (China); Key Laboratory of Particle and Radiation Imaging, Tsinghua University, Ministry of Education (China)

    2012-01-01

    Multi-gap resistive plate chamber (MRPC), which is mostly developed in high energy physics domain with excellent time resolution, is also highlighted in imaging applications. A set of 50 cm Multiplication-Sign 50 cm large area MRPC with high position resolution was successfully developed by our group and different experiments have been done to test its performances. Cosmic ray muons were used to do the test and proper high voltage and working gas were chosen. Data analysis indicates its good detection efficiency and good position resolution, which encourages further study of its application in RPC-PET and muon tomography.

  6. Internal quality evolution of a large test system – an industrial study

    Directory of Open Access Journals (Sweden)

    Kovács Attila

    2016-12-01

    Full Text Available This paper presents our empirical observations related to the evolution of a large automated test system. The system observed is used in the industry as a test tool for complex telecommunication systems, itself consisting of more than one million lines of source code. This study evaluates how different changes during the development have changed the number of observed Code Smells in the test system. We have monitored the development of the test scripts and measured the code quality characteristics over a five years period.

  7. Sensitivity of local air quality to the interplay between small- and large-scale circulations: a large-eddy simulation study

    Directory of Open Access Journals (Sweden)

    T. Wolf-Grosse

    2017-06-01

    Full Text Available Street-level urban air pollution is a challenging concern for modern urban societies. Pollution dispersion models assume that the concentrations decrease monotonically with raising wind speed. This convenient assumption breaks down when applied to flows with local recirculations such as those found in topographically complex coastal areas. This study looks at a practically important and sufficiently common case of air pollution in a coastal valley city. Here, the observed concentrations are determined by the interaction between large-scale topographically forced and local-scale breeze-like recirculations. Analysis of a long observational dataset in Bergen, Norway, revealed that the most extreme cases of recurring wintertime air pollution episodes were accompanied by increased large-scale wind speeds above the valley. Contrary to the theoretical assumption and intuitive expectations, the maximum NO2 concentrations were not found for the lowest 10 m ERA-Interim wind speeds but in situations with wind speeds of 3 m s−1. To explain this phenomenon, we investigated empirical relationships between the large-scale forcing and the local wind and air quality parameters. We conducted 16 large-eddy simulation (LES experiments with the Parallelised Large-Eddy Simulation Model (PALM for atmospheric and oceanic flows. The LES accounted for the realistic relief and coastal configuration as well as for the large-scale forcing and local surface condition heterogeneity in Bergen. They revealed that emerging local breeze-like circulations strongly enhance the urban ventilation and dispersion of the air pollutants in situations with weak large-scale winds. Slightly stronger large-scale winds, however, can counteract these local recirculations, leading to enhanced surface air stagnation. Furthermore, this study looks at the concrete impact of the relative configuration of warmer water bodies in the city and the major transport corridor. We found that a

  8. Sensitivity of local air quality to the interplay between small- and large-scale circulations: a large-eddy simulation study

    Science.gov (United States)

    Wolf-Grosse, Tobias; Esau, Igor; Reuder, Joachim

    2017-06-01

    Street-level urban air pollution is a challenging concern for modern urban societies. Pollution dispersion models assume that the concentrations decrease monotonically with raising wind speed. This convenient assumption breaks down when applied to flows with local recirculations such as those found in topographically complex coastal areas. This study looks at a practically important and sufficiently common case of air pollution in a coastal valley city. Here, the observed concentrations are determined by the interaction between large-scale topographically forced and local-scale breeze-like recirculations. Analysis of a long observational dataset in Bergen, Norway, revealed that the most extreme cases of recurring wintertime air pollution episodes were accompanied by increased large-scale wind speeds above the valley. Contrary to the theoretical assumption and intuitive expectations, the maximum NO2 concentrations were not found for the lowest 10 m ERA-Interim wind speeds but in situations with wind speeds of 3 m s-1. To explain this phenomenon, we investigated empirical relationships between the large-scale forcing and the local wind and air quality parameters. We conducted 16 large-eddy simulation (LES) experiments with the Parallelised Large-Eddy Simulation Model (PALM) for atmospheric and oceanic flows. The LES accounted for the realistic relief and coastal configuration as well as for the large-scale forcing and local surface condition heterogeneity in Bergen. They revealed that emerging local breeze-like circulations strongly enhance the urban ventilation and dispersion of the air pollutants in situations with weak large-scale winds. Slightly stronger large-scale winds, however, can counteract these local recirculations, leading to enhanced surface air stagnation. Furthermore, this study looks at the concrete impact of the relative configuration of warmer water bodies in the city and the major transport corridor. We found that a relatively small local water

  9. Video Lecture Capture Technology Helps Students Study without Affecting Attendance in Large Microbiology Lecture Courses

    Directory of Open Access Journals (Sweden)

    Jennifer Lynn McLean

    2016-12-01

    Full Text Available Recording lectures using video lecture capture software and making them available for students to watch anytime, from anywhere, has become a common practice in many universities across many disciplines. The software has become increasingly easy to use and is commonly provided and maintained by higher education institutions. Several studies have reported that students use lecture capture to enhance their learning and study for assessments, as well as to catch up on material they miss when they cannot attend class due to extenuating circumstances. Furthermore, students with disabilities and students from non-English Speaking Backgrounds (NESB may benefit from being able to watch the video lecture captures at their own pace. Yet, the effect of this technology on class attendance remains a controversial topic and largely unexplored in undergraduate microbiology education. Here, we show that when video lecture captures were available in our large enrollment general microbiology courses, attendance did not decrease. In fact, the majority of students reported that having the videos available did not encourage them to skip class, but rather they used them as a study tool. When we surveyed NESB students and nontraditional students about their attitudes toward this technology, they found it helpful for their learning and for keeping up with the material.

  10. Study of hydrodynamic behaviour of large bearings depending on the viscosity of the lubricant

    Directory of Open Access Journals (Sweden)

    Barabas Sorin

    2017-01-01

    Full Text Available The research refers to study of hydrodynamic behavior of large bearings equipped with automatic lubrication system, where the liquid used may have a viscosity with variable values depending on the temperature or depending on the additive used. The introduction of additives with nanoparticles causes modification of viscosity and a significant reduction of friction coefficient. This study establishes a direct link between the friction, viscosity and tensions that occur in the contact area. Experimental studies confirm improving tribological properties of the contact area between the bearing rollers and raceways, through attracting nanoparticles on surfaces in contact and reducing friction coefficient. Accomplished finite element analysis showed decrease of the contact stresses, therefore decrease of the wear and increase the life of the bearing. Research has concluded that influencing viscosity and friction coefficient of lubricant can result in reducing wear of the bearing components, as well as increase the lifetime of bearing.

  11. Transanal endoscopic microsurgery versus endoscopic mucosal resection for large rectal adenomas (TREND-study).

    Science.gov (United States)

    van den Broek, Frank J C; de Graaf, Eelco J R; Dijkgraaf, Marcel G W; Reitsma, Johannes B; Haringsma, Jelle; Timmer, Robin; Weusten, Bas L A M; Gerhards, Michael F; Consten, Esther C J; Schwartz, Matthijs P; Boom, Maarten J; Derksen, Erik J; Bijnen, A Bart; Davids, Paul H P; Hoff, Christiaan; van Dullemen, Hendrik M; Heine, G Dimitri N; van der Linde, Klaas; Jansen, Jeroen M; Mallant-Hent, Rosalie C H; Breumelhof, Ronald; Geldof, Han; Hardwick, James C H; Doornebosch, Pascal G; Depla, Annekatrien C T M; Ernst, Miranda F; van Munster, Ivo P; de Hingh, Ignace H J T; Schoon, Erik J; Bemelman, Willem A; Fockens, Paul; Dekker, Evelien

    2009-03-13

    Recent non-randomized studies suggest that extended endoscopic mucosal resection (EMR) is equally effective in removing large rectal adenomas as transanal endoscopic microsurgery (TEM). If equally effective, EMR might be a more cost-effective approach as this strategy does not require expensive equipment, general anesthesia and hospital admission. Furthermore, EMR appears to be associated with fewer complications.The aim of this study is to compare the cost-effectiveness and cost-utility of TEM and EMR for the resection of large rectal adenomas. Multicenter randomized trial among 15 hospitals in the Netherlands. Patients with a rectal adenoma > or = 3 cm, located between 1-15 cm ab ano, will be randomized to a TEM- or EMR-treatment strategy. For TEM, patients will be treated under general anesthesia, adenomas will be dissected en-bloc by a full-thickness excision, and patients will be admitted to the hospital. For EMR, no or conscious sedation is used, lesions will be resected through the submucosal plane in a piecemeal fashion, and patients will be discharged from the hospital. Residual adenoma that is visible during the first surveillance endoscopy at 3 months will be removed endoscopically in both treatment strategies and is considered as part of the primary treatment. Primary outcome measure is the proportion of patients with recurrence after 3 months. Secondary outcome measures are: 2) number of days not spent in hospital from initial treatment until 2 years afterwards; 3) major and minor morbidity; 4) disease specific and general quality of life; 5) anorectal function; 6) health care utilization and costs. A cost-effectiveness and cost-utility analysis of EMR against TEM for large rectal adenomas will be performed from a societal perspective with respectively the costs per recurrence free patient and the cost per quality adjusted life year as outcome measures. Based on comparable recurrence rates for TEM and EMR of 3.3% and considering an upper-limit of 10

  12. Transanal endoscopic microsurgery versus endoscopic mucosal resection for large rectal adenomas (TREND-study

    Directory of Open Access Journals (Sweden)

    Geldof Han

    2009-03-01

    Full Text Available Abstract Background Recent non-randomized studies suggest that extended endoscopic mucosal resection (EMR is equally effective in removing large rectal adenomas as transanal endoscopic microsurgery (TEM. If equally effective, EMR might be a more cost-effective approach as this strategy does not require expensive equipment, general anesthesia and hospital admission. Furthermore, EMR appears to be associated with fewer complications. The aim of this study is to compare the cost-effectiveness and cost-utility of TEM and EMR for the resection of large rectal adenomas. Methods/design Multicenter randomized trial among 15 hospitals in the Netherlands. Patients with a rectal adenoma ≥ 3 cm, located between 1–15 cm ab ano, will be randomized to a TEM- or EMR-treatment strategy. For TEM, patients will be treated under general anesthesia, adenomas will be dissected en-bloc by a full-thickness excision, and patients will be admitted to the hospital. For EMR, no or conscious sedation is used, lesions will be resected through the submucosal plane in a piecemeal fashion, and patients will be discharged from the hospital. Residual adenoma that is visible during the first surveillance endoscopy at 3 months will be removed endoscopically in both treatment strategies and is considered as part of the primary treatment. Primary outcome measure is the proportion of patients with recurrence after 3 months. Secondary outcome measures are: 2 number of days not spent in hospital from initial treatment until 2 years afterwards; 3 major and minor morbidity; 4 disease specific and general quality of life; 5 anorectal function; 6 health care utilization and costs. A cost-effectiveness and cost-utility analysis of EMR against TEM for large rectal adenomas will be performed from a societal perspective with respectively the costs per recurrence free patient and the cost per quality adjusted life year as outcome measures. Based on comparable recurrence rates for TEM and EMR

  13. A Study of the Efficiency of Spatial Indexing Methods Applied to Large Astronomical Databases

    Science.gov (United States)

    Donaldson, Tom; Berriman, G. Bruce; Good, John; Shiao, Bernie

    2018-01-01

    Spatial indexing of astronomical databases generally uses quadrature methods, which partition the sky into cells used to create an index (usually a B-tree) written as database column. We report the results of a study to compare the performance of two common indexing methods, HTM and HEALPix, on Solaris and Windows database servers installed with a PostgreSQL database, and a Windows Server installed with MS SQL Server. The indexing was applied to the 2MASS All-Sky Catalog and to the Hubble Source catalog. On each server, the study compared indexing performance by submitting 1 million queries at each index level with random sky positions and random cone search radius, which was computed on a logarithmic scale between 1 arcsec and 1 degree, and measuring the time to complete the query and write the output. These simulated queries, intended to model realistic use patterns, were run in a uniform way on many combinations of indexing method and indexing level. The query times in all simulations are strongly I/O-bound and are linear with number of records returned for large numbers of sources. There are, however, considerable differences between simulations, which reveal that hardware I/O throughput is a more important factor in managing the performance of a DBMS than the choice of indexing scheme. The choice of index itself is relatively unimportant: for comparable index levels, the performance is consistent within the scatter of the timings. At small index levels (large cells; e.g. level 4; cell size 3.7 deg), there is large scatter in the timings because of wide variations in the number of sources found in the cells. At larger index levels, performance improves and scatter decreases, but the improvement at level 8 (14 min) and higher is masked to some extent in the timing scatter caused by the range of query sizes. At very high levels (20; 0.0004 arsec), the granularity of the cells becomes so high that a large number of extraneous empty cells begin to degrade

  14. Transitioning a home telehealth project into a sustainable, large-scale service: a qualitative study.

    Science.gov (United States)

    Wade, Victoria A; Taylor, Alan D; Kidd, Michael R; Carati, Colin

    2016-05-16

    This study was a component of the Flinders Telehealth in the Home project, which tested adding home telehealth to existing rehabilitation, palliative care and geriatric outreach services. Due to the known difficulty of transitioning telehealth projects services, a qualitative study was conducted to produce a preferred implementation approach for sustainable and large-scale operations, and a process model that offers practical advice for achieving this goal. Initially, semi-structured interviews were conducted with senior clinicians, health service managers and policy makers, and a thematic analysis of the interview transcripts was undertaken to identify the range of options for ongoing operations, plus the factors affecting sustainability. Subsequently, the interviewees and other decision makers attended a deliberative forum in which participants were asked to select a preferred model for future implementation. Finally, all data from the study was synthesised by the researchers to produce a process model. 19 interviews with senior clinicians, managers, and service development staff were conducted, finding strong support for home telehealth but a wide diversity of views on governance, models of clinical care, technical infrastructure operations, and data management. The deliberative forum worked through these options and recommended a collaborative consortium approach for large-scale implementation. The process model proposes that the key factor for large-scale implementation is leadership support, which is enabled by 1) showing solutions to the problems of service demand, budgetary pressure and the relationship between hospital and primary care, 2) demonstrating how home telehealth aligns with health service policies, and 3) achieving clinician acceptance through providing evidence of benefit and developing new models of clinical care. Two key actions to enable change were marketing telehealth to patients, clinicians and policy-makers, and building a community of

  15. Structural consequences of diffuse traumatic brain injury: A large deformation tensor-based morphometry study

    Science.gov (United States)

    Kim, Junghoon; Avants, Brian; Patel, Sunil; Whyte, John; Coslett, H. Branch; Pluta, John; Detre, John A.; Gee, James C.

    2008-01-01

    Traumatic brain injury (TBI) is one of the most common causes of long-term disability. Despite the importance of identifying neuropathology in individuals with chronic TBI, methodological challenges posed at the stage of inter-subject image registration have hampered previous voxel-based MRI studies from providing a clear pattern of structural atrophy after TBI. We used a novel symmetric diffeomorphic image normalization method to conduct a tensor-based morphometry (TBM) study of TBI. The key advantage of this method is that it simultaneously estimates an optimal template brain and topology preserving deformations between this template and individual subject brains. Detailed patterns of atrophies are then revealed by statistically contrasting control and subject deformations to the template space. Participants were 29 survivors of TBI and 20 control subjects who were matched in terms of age, gender, education, and ethnicity. Localized volume losses were found most prominently in white matter regions and the subcortical nuclei including the thalamus, the midbrain, the corpus callosum, the mid- and posterior cingulate cortices, and the caudate. Significant voxel-wise volume loss clusters were also detected in the cerebellum and the frontal/temporal neocortices. Volume enlargements were identified largely in ventricular regions. A similar pattern of results was observed in a subgroup analysis where we restricted our analysis to the 17 TBI participants who had no macroscopic focal lesions (total lesion volume> 1.5 cm 3). The current study confirms, extends, and partly challenges previous structural MRI studies in chronic TBI. By demonstrating that a large deformation image registration technique can be successfully combined with TBM to identify TBI-induced diffuse structural changes with greater precision, our approach is expected to increase the sensitivity of future studies examining brain-behavior relationships in the TBI population. PMID:17999940

  16. A large-scale study of epilepsy in Ecuador: methodological aspects.

    Science.gov (United States)

    Placencia, M; Suarez, J; Crespo, F; Sander, J W; Shorvon, S D; Ellison, R H; Cascante, S M

    1992-01-01

    The methodology is presented of a large-scale study of epilepsy carried out in a highland area in northern Ecuador, South America, covering a population of 72,121 people; The study was carried out in two phases, the first, a cross-sectional phase, consisted of a house-to-house survey of all persons in this population, screening for epileptic seizures using a specially designed questionnaire. Possible cases identified in screening were assessed in a cascade diagnostic procedure applied by general doctors and neurologists. Its objectives were: to establish a comprehensive epidemiological profile of epileptic seizures; to describe the clinical phenomenology of this condition in the community; to validate methods for diagnosis and classification of epileptic seizures by a non-specialised team; and to ascertain the community's knowledge, attitudes and practices regarding epilepsy. A sample was selected in this phase in order to study the social aspects of epilepsy in this community. The second phase, which was longitudinal, assessed the ability of non-specialist care in the treatment of epilepsy. It consisted of a prospective clinical trial of antiepileptic therapy in untreated patients using two standard anti-epileptic drugs. Patients were followed for 12 months by a multidisciplinary team consisting of a primary health worker, rural doctor, neurologist, anthropologist, and psychologist. Standardised, reproducible instruments and methods were used. This study was carried out through co-operation between the medical profession, political agencies and the pharmaceutical industry, at an international level. We consider this a model for further large-scale studies of this type.

  17. Relationship between homocysteine and coronary artery disease. Results from a large prospective cohort study.

    Science.gov (United States)

    Schaffer, Alon; Verdoia, Monica; Cassetti, Ettore; Marino, Paolo; Suryapranata, Harry; De Luca, Giuseppe

    2014-08-01

    Coronary artery disease (CAD) still represents the major cause of mortality in developed countries. Large research programs have been focused on the identification of new risk factors to prevent CAD, with special attention to homocysteine (Hcy), due to the known associated increased thrombogenicity, oxidative stress status and endothelial dysfunction. However, controversy still exists on the association between Hcy and CAD. Therefore, aim of the current study was to investigate the association of Hcy with the prevalence and extent of CAD in a large consecutive cohort of patients undergoing coronary angiography. Our population is represented by a total of 3056 consecutive patients undergoing coronary angiography between at the Azienda Ospedaliera "Maggiore della Carità", Novara, Italy. Fasting samples were collected for homocysteine levels assessment. Coronary disease was defined for at least 1 vessel stenosis>50% as evaluated by QCA. Study population was divided according to Hcy tertiles (18.2nmol/ml). High plasmatic level of homocysteine was related with age (pbenefits from vitamin administration in patients with elevated Hcy to prevent the occurrence and progression of CAD. Copyright © 2014 Elsevier Ltd. All rights reserved.

  18. Developing Routines in Large Inter-organisational Projects: A Case Study of an Infrastructure Megaproject

    Directory of Open Access Journals (Sweden)

    Therese Eriksson

    2015-08-01

    Full Text Available General management research has increasingly recognised the significance of routines in organisational performance. Among organisational tasks, megaprojects depend more on routines selected and created within the project than standard, small-scale projects do, owing largely to their size, duration, and uniqueness. Within this context, the present paper investigates how project routines were established and developed during the early design phase of an inter-organisational megaproject. A case study of a large public infrastructure project was conducted, in which data were collected during observations, semi-structured interviews, and project document studies over the course of three years. Results of analysis revealed that the client exerted the greatest impact on choice of routines and that the temporary nature of tasks limited efforts to fine-tune routines. Changes in routines were primarily reactive to new knowledge concerning project needs. The findings suggest that meta-routines to consciously review routines should be used to a greater extent and designed to capture supplier experiences as well.

  19. Simulating large-scale pedestrian movement using CA and event driven model: Methodology and case study

    Science.gov (United States)

    Li, Jun; Fu, Siyao; He, Haibo; Jia, Hongfei; Li, Yanzhong; Guo, Yi

    2015-11-01

    Large-scale regional evacuation is an important part of national security emergency response plan. Large commercial shopping area, as the typical service system, its emergency evacuation is one of the hot research topics. A systematic methodology based on Cellular Automata with the Dynamic Floor Field and event driven model has been proposed, and the methodology has been examined within context of a case study involving the evacuation within a commercial shopping mall. Pedestrians walking is based on Cellular Automata and event driven model. In this paper, the event driven model is adopted to simulate the pedestrian movement patterns, the simulation process is divided into normal situation and emergency evacuation. The model is composed of four layers: environment layer, customer layer, clerk layer and trajectory layer. For the simulation of movement route of pedestrians, the model takes into account purchase intention of customers and density of pedestrians. Based on evacuation model of Cellular Automata with Dynamic Floor Field and event driven model, we can reflect behavior characteristics of customers and clerks at the situations of normal and emergency evacuation. The distribution of individual evacuation time as a function of initial positions and the dynamics of the evacuation process is studied. Our results indicate that the evacuation model using the combination of Cellular Automata with Dynamic Floor Field and event driven scheduling can be used to simulate the evacuation of pedestrian flows in indoor areas with complicated surroundings and to investigate the layout of shopping mall.

  20. A large study reveals no Association between APOE and Parkinson’s disease

    Science.gov (United States)

    Federoff, Monica; Jimenez-Rolando, Belen; Nalls, Michael A; Singleton, Andrew B

    2012-01-01

    Background Research focusing on the role of APOE in Parkinson’s disease (PD) has been largely inconclusive, creating a broad discrepancy in association studies. Objective To elucidate the role of APOE alleles in PD risk by studying a large sample size and controlling for population substructure. Patients and Methods In total, 3465 case and control samples were genotyped, obtained from the NINDS Neurogenetics repository. Results No significant differences in ε4 dosages exist between PD cases and controls. The frequency of ε4 carriers differed slightly between cases and controls at 24% (580/2412) and 26% (270/1053), respectively. Likewise, mean dosages of APOE ε2 were not significantly different between cases and controls. APOE ε2 carriers were observed at a frequency of 13.6% (329/2412) among cases and 15% (158/1053) among controls. Logistic regression models evaluating PD as possibly associated with ε4 or ε2 carrier status and allele dosages yielded no significant results. The mean MMSE score among all PD cases was 28.35 (SD = 2.58) and memory loss was reported in only 11.9% (105/879) of cases. Linear regression models comparing MMSE scores as predicted by ε4 or ε2 carrier status and allele dosages were not significant. Conclusions There is no association between APOE epsilon alleles and Parkinson’s disease. PMID:22349451

  1. A study of residence time distribution using radiotracer technique in the large scale plant facility

    Science.gov (United States)

    Wetchagarun, S.; Tippayakul, C.; Petchrak, A.; Sukrod, K.; Khoonkamjorn, P.

    2017-06-01

    As the demand for troubleshooting of large industrial plants increases, radiotracer techniques, which have capability to provide fast, online and effective detections to plant problems, have been continually developed. One of the good potential applications of the radiotracer for troubleshooting in a process plant is the analysis of Residence Time Distribution (RTD). In this paper, the study of RTD in a large scale plant facility using radiotracer technique was presented. The objective of this work is to gain experience on the RTD analysis using radiotracer technique in a “larger than laboratory” scale plant setup which can be comparable to the real industrial application. The experiment was carried out at the sedimentation tank in the water treatment facility of Thailand Institute of Nuclear Technology (Public Organization). Br-82 was selected to use in this work due to its chemical property, its suitable half-life and its on-site availability. NH4Br in the form of aqueous solution was injected into the system as the radiotracer. Six NaI detectors were placed along the pipelines and at the tank in order to determine the RTD of the system. The RTD and the Mean Residence Time (MRT) of the tank was analysed and calculated from the measured data. The experience and knowledge attained from this study is important for extending this technique to be applied to industrial facilities in the future.

  2. Experimental study of falling film evaporation in large scale rectangular channel

    International Nuclear Information System (INIS)

    Huang, X.G.; Yang, Y.H.; Hu, P.

    2015-01-01

    Highlights: • This paper studies the falling film evaporation in large scale rectangular channel experimentally. • The effects of air flow rate, film temperature and film flow rate on falling film evaporation are analyzed. • Increasing the air flow rate is considered as an efficient method to enhance the evaporation rate. • A correlation including the wave effect for falling film evaporation is derived based on heat and mass transfer analogy. - Abstract: The falling film evaporation in a large scale rectangular channel is experimentally studied in this paper for the design and improvement of passive containment cooling system. The evaporation mass transfer coefficient h D is obtained by the evaporation rate and vapor partial pressure difference of film surface and air bulk. The experimental results indicate that increasing of air flow rate appears to enhance h D , while the film temperature and film flow rate have little effect on h D . Since the wave effect on evaporation is noticed in experiment, the evaporation mass transfer correlation including the wave effect is developed on the basis of heat and mass transfer analogy and experimental data

  3. User Friendly Open GIS Tool for Large Scale Data Assimilation - a Case Study of Hydrological Modelling

    Science.gov (United States)

    Gupta, P. K.

    2012-08-01

    Open source software (OSS) coding has tremendous advantages over proprietary software. These are primarily fuelled by high level programming languages (JAVA, C++, Python etc...) and open source geospatial libraries (GDAL/OGR, GEOS, GeoTools etc.). Quantum GIS (QGIS) is a popular open source GIS package, which is licensed under GNU GPL and is written in C++. It allows users to perform specialised tasks by creating plugins in C++ and Python. This research article emphasises on exploiting this capability of QGIS to build and implement plugins across multiple platforms using the easy to learn - Python programming language. In the present study, a tool has been developed to assimilate large spatio-temporal datasets such as national level gridded rainfall, temperature, topographic (digital elevation model, slope, aspect), landuse/landcover and multi-layer soil data for input into hydrological models. At present this tool has been developed for Indian sub-continent. An attempt is also made to use popular scientific and numerical libraries to create custom applications for digital inclusion. In the hydrological modelling calibration and validation are important steps which are repetitively carried out for the same study region. As such the developed tool will be user friendly and used efficiently for these repetitive processes by reducing the time required for data management and handling. Moreover, it was found that the developed tool can easily assimilate large dataset in an organised manner.

  4. A statewide review of postnatal care in private hospitals in Victoria, Australia

    Directory of Open Access Journals (Sweden)

    Forster Della A

    2010-05-01

    Full Text Available Abstract Background Concerns have been raised in Australia and internationally regarding the quality and effectiveness of hospital postnatal care, although Australian women receiving postnatal care in the private maternity sector rate their satisfaction with care more highly than women receiving public maternity care. In Victoria, Australia, two-thirds of women receive their maternity care in the public sector and the remainder in private health care sector. A statewide review of public hospital postnatal care in Victoria from the perspective of care providers found many barriers to care provision including the busyness of postnatal wards, inadequate staffing and priority being given to other episodes of care; however the study did not include private hospitals. The aim of this study was replicate the review in the private sector, to explore the structure and organisation of postnatal care in private hospitals and identify those aspects of care potentially impacting on women's experiences and maternal and infant care. This provides a more complete overview of the organisational structures and processes in postnatal care in all Victorian hospitals from the perspective of care providers. Methods A mixed method design was used. A structured postal survey was sent to all Victorian private hospitals (n = 19 and key informant interviews were undertaken with selected clinical midwives, maternity unit managers and obstetricians (n = 11. Survey data were analysed using descriptive statistics and interview data analysed thematically. Results Private hospital care providers report that postnatal care is provided in very busy environments, and that meeting the aims of postnatal care (breastfeeding support, education of parents and facilitating rest and recovery for women following birth was difficult in the context of increased acuity of postnatal care; prioritising of other areas over postnatal care; high midwife-to-woman ratios; and the number and

  5. Economic and Humanistic Burden of Osteoarthritis: A Systematic Review of Large Sample Studies.

    Science.gov (United States)

    Xie, Feng; Kovic, Bruno; Jin, Xuejing; He, Xiaoning; Wang, Mengxiao; Silvestre, Camila

    2016-11-01

    Osteoarthritis (OA) consumes a significant amount of healthcare resources, and impairs the health-related quality of life (HRQoL) of patients. Previous reviews have consistently found substantial variations in the costs of OA across studies and countries. The comparability between studies was poor and limited the detection of the true differences between these studies. To review large sample studies on measuring the economic and/or humanistic burden of OA published since May 2006. We searched MEDLINE and EMBASE databases using comprehensive search strategies to identify studies reporting economic burden and HRQoL of OA. We included large sample studies if they had a sample size ≥1000 and measured the cost and/or HRQoL of OA. Reviewers worked independently and in duplicate, performing a cross-check between groups to verify agreement. Within- and between-group consolidation was performed to resolve discrepancies, with outstanding discrepancies being resolved by an arbitrator. The Kappa statistic was reported to assess the agreement between the reviewers. All costs were adjusted in their original currency to year 2015 using published inflation rates for the country where the study was conducted, and then converted to 2015 US dollars. A total of 651 articles were screened by title and abstract, 94 were reviewed in full text, and 28 were included in the final review. The Kappa value was 0.794. Twenty studies reported direct costs and nine reported indirect costs. The total annual average direct costs varied from US$1442 to US$21,335, both in USA. The annual average indirect costs ranged from US$238 to US$29,935. Twelve studies measured HRQoL using various instruments. The Short Form 12 version 2 scores ranged from 35.0 to 51.3 for the physical component, and from 43.5 to 55.0 for the mental component. Health utilities varied from 0.30 for severe OA to 0.77 for mild OA. Per-patient OA costs are considerable and a patient's quality of life remains poor. Variations in

  6. A study of diabetes mellitus within a large sample of Australian twins

    DEFF Research Database (Denmark)

    Condon, Julianne; Shaw, Joanne E; Luciano, Michelle

    2008-01-01

    with type 2 diabetes (T2D), 41 female pairs with gestational diabetes (GD), 5 pairs with impaired glucose tolerance (IGT) and one pair with MODY. Heritabilities of T1D, T2D and GD were all high, but our samples did not have the power to detect effects of shared environment unless they were very large......Twin studies of diabetes mellitus can help elucidate genetic and environmental factors in etiology and can provide valuable biological samples for testing functional hypotheses, for example using expression and methylation studies of discordant pairs. We searched the volunteer Australian Twin...... Registry (19,387 pairs) for twins with diabetes using disease checklists from nine different surveys conducted from 1980-2000. After follow-up questionnaires to the twins and their doctors to confirm diagnoses, we eventually identified 46 pairs where one or both had type 1 diabetes (T1D), 113 pairs...

  7. Carbon offsets as an economic alternative to large-scale logging: a case study in Guyana

    Energy Technology Data Exchange (ETDEWEB)

    Osborne, T. [Energy and Resources Group, University of California Berkeley, 310 Barrows Hall, Berkeley CA 94720 (United States); Kiker, C. [Food and Resource Economics Department, University of Florida, PO Box 110240, Gainesville, FL 32611 (United States)

    2005-03-01

    The objective of this study is to analyze the economic viability of carbon-offset projects that avoid logging in Guyana's forests. The results of this case study illustrate the cost effectiveness of alternative land-use options that reduce deforestation and associated greenhouse gas (GHG) emissions. This analysis demonstrates that using Guyana's rainforests for climate change mitigation can generate equivalent revenue to that of conventional large-scale logging without detrimental environmental impacts. At a 12% discount rate, the break-even price for carbon is estimated to be about US$ 0.20/tC. This estimate falls toward the low range of carbon prices for existing carbon offset projects that avoid deforestation.

  8. Study of the high energy Cosmic Rays large scale anisotropies with the ANTARES neutrino telescope

    International Nuclear Information System (INIS)

    Illuminati, Giulia

    2016-01-01

    We present the analysis method used to search for an anisotropy in the high energy Cosmic Rays arrival distribution using data collected by the ANTARES telescope. ANTARES is a neutrino detector, where the collected data are dominated by a large background of cosmic ray muons. Therefore, the background data are suitable for high-statistics studies of cosmic rays in the Northern sky. The main challenge for this analysis is accounting for those effects which can mimic an apparent anisotropy in the muon arrival direction: the detector exposure asymmetries, non-uniform time coverage, diurnal and seasonal variation of the atmospheric temperature. Once all these effects have been corrected, a study of the anisotropy profiles along the right ascension can be performed. (paper)

  9. Accidents at work and costs analysis: a field study in a large Italian company.

    Science.gov (United States)

    Battaglia, Massimo; Frey, Marco; Passetti, Emilio

    2014-01-01

    Accidents at work are still a heavy burden in social and economic terms, and action to improve health and safety standards at work offers great potential gains not only to employers, but also to individuals and society as a whole. However, companies often are not interested to measure the costs of accidents even if cost information may facilitate preventive occupational health and safety management initiatives. The field study, carried out in a large Italian company, illustrates technical and organisational aspects associated with the implementation of an accident costs analysis tool. The results indicate that the implementation (and the use) of the tool requires a considerable commitment by the company, that accident costs analysis should serve to reinforce the importance of health and safety prevention and that the economic dimension of accidents is substantial. The study also suggests practical ways to facilitate the implementation and the moral acceptance of the accounting technology.

  10. Course of Tourette Syndrome and Comorbidities in a Large Prospective Clinical Study

    DEFF Research Database (Denmark)

    Groth, Camilla; Mol Debes, Nanette; Rask, Charlotte Ulrikka

    2017-01-01

    Objective: Tourette syndrome (TS) is a childhood-onset neurodevelopmental disorder characterized by tics and frequent comorbidities. Although tics often improve during adolescence, recent studies suggest that comorbid obsessive-compulsive disorder (OCD) and attention-deficit/hyperactivity disorder...... (ADHD) tend to persist. This large prospective follow-up study describes the clinical course of tics and comorbidities during adolescence and the prevalence of coexisting psychopathologies. Method: The clinical cohort was recruited at the Danish National Tourette Clinic, and data were collected...... at baseline (n = 314, age range 5–19 years) and at follow-up 6 years later (n = 227) to establish the persistence and severity of tics and comorbidities. During follow-up, the Development and Well-Being Assessment (DAWBA) was used to diagnose coexisting psychopathologies. Repeated measures of severity scores...

  11. Predictors of switching from mania to depression in a large observational study across Europe (EMBLEM)

    DEFF Research Database (Denmark)

    Vieta, Eduard; Angst, Jules; Reed, Catherine

    2009-01-01

    BACKGROUND: The risk of switching from mania to depression in bipolar disorder has been poorly studied. Large observational studies may be useful in identifying variables that predict switch to depression after mania and provide data on medication use and outcomes in "real world" patients. METHOD...... Depression Rating Scale. Switching was defined using CGI-BP mania and depression such that patients changed from manic and not depressed to depressed but not manic over two consecutive observations within the first 12 weeks of follow-up. Cox proportional hazards models identified baseline variables...... independently associated with switch to depression. RESULTS: Of 2390 patients who participated in the maintenance phase (i.e. up to 24 months), 120 (5.0%) switched to depression within the first 12 weeks. Factors associated with greater switching to depression include previous depressive episodes, substance...

  12. Open-loop groundwater heat pumps development for large buildings. A case study

    Energy Technology Data Exchange (ETDEWEB)

    Lo Russo, Stefano; Civita, Massimo Vincenzo [Politecnico di Torino, Dipartimento di Ingegneria del Territorio, dell' Ambiente e delle Geotecnologie (DITAG), Corso Duca degli Abruzzi, 24 - 10129 Torino (Italy)

    2009-09-15

    A study of the feasibility of providing the heating and cooling needs of the new, large commercial building near Turin, Italy, by means of an open-loop indirect groundwater heat pump (GWHP) system is described. A finite element subsurface flow and transport simulator (FEFLOW) was used to investigate possible configurations of extraction and injection wells for five different scenarios. Modelling results confirmed the hydrogeological capacity of the site to provide the necessary amount of groundwater and associated energy with limited environmental impact. Injection of warmer (or cooler) water in the aquifer creates a thermal plume whose dimensions and geometry depend on the properties of the subsurface formations, particularly their thermal dispersivity values. The study suggests that there are several possible well configurations that could support the GWHP system without adversely affecting the aquifer. (author)

  13. Study for a failsafe trigger generation system for the Large Hadron Collider beam dump kicker magnets

    CERN Document Server

    Rampl, M

    1999-01-01

    The 27 km-particle accelerator Large Hadron Collider (LHC), which will be completed at the European Laboratory for Particle Physics (CERN) in 2005, will work with extremely high beam energies (~334 MJ per beam). Since the equipment and in particular the superconducting magnets must be protected from damage caused by these high energy beams the beam dump must be able to absorb this energy very reliable at every stage of operation. The kicker magnets that extract the particles from the accelerator are synchronised with the beam by the trigger generation system. This thesis is a first study for this electronic module and its functions. A special synchronisation circuit and a very reliable electronic switch were developed. Most functions were implemented in a Gate-Array to improve the reliability and to facilitate modifications during the test stage. This study also comprises the complete concept for the prototype of the trigger generation system. During all project stages reliability was always the main determin...

  14. Accidents at Work and Costs Analysis: A Field Study in a Large Italian Company

    Science.gov (United States)

    BATTAGLIA, Massimo; FREY, Marco; PASSETTI, Emilio

    2014-01-01

    Accidents at work are still a heavy burden in social and economic terms, and action to improve health and safety standards at work offers great potential gains not only to employers, but also to individuals and society as a whole. However, companies often are not interested to measure the costs of accidents even if cost information may facilitate preventive occupational health and safety management initiatives. The field study, carried out in a large Italian company, illustrates technical and organisational aspects associated with the implementation of an accident costs analysis tool. The results indicate that the implementation (and the use) of the tool requires a considerable commitment by the company, that accident costs analysis should serve to reinforce the importance of health and safety prevention and that the economic dimension of accidents is substantial. The study also suggests practical ways to facilitate the implementation and the moral acceptance of the accounting technology. PMID:24869894

  15. Incidence of Headache After Traumatic Brain Injury in China: A Large Prospective Study.

    Science.gov (United States)

    Xu, Hongmei; Pi, Hongying; Ma, Lili; Su, Xinyang; Wang, Jianrong

    2016-04-01

    There have yet to be any large-scale studies in China on headaches after traumatic brain injury (TBI). We evaluate the incidence of headache after TBI and investigate risk factors and functional outcome in a large tertiary center with a high caseload. A total of 543 patients (82% men, 18% women) with a mean age of 48.4 ± 18.6 years presenting with TBI were prospectively enrolled in this study between March 2011 and July 2013. Patient demographics, severity of TBI, incidence and classification of headache, and treatment information were collected during initial hospitalization and at 3, 6, and 12 months follow-up. Of our 543 patients (82% men, 18% women), 62% were injured in motor vehicle collisions and 27% in falls. Most patients (97%) were considered to have mild TBI. Follow-up rates at 3, 6, and 12 months were 91%, 75%, and 61%, respectively. Only 12% of patients reported pre-TBI headaches, whereas 58% of respondents reported headache at 3 months follow-up, 54% at 6 months follow-up, and 49% at 1 year follow-up. No statistically significant correlations between age, sex, or TBI severity and posttraumatic headaches were observed. We present the findings of the first study on headaches after TBI in China. Headaches were found to occur in most patients with TBI and persisted through the first year after injury. The incidence of posttraumatic headache observed here is comparable with previously published studies outside China. Copyright © 2016 Elsevier Inc. All rights reserved.

  16. Study of SUSY particles properties at the future International Linear Collider with the International Large Detector

    International Nuclear Information System (INIS)

    Wichmann, K.

    2009-01-01

    Recently, Letters of Intent (LoI) for experiments at the International Linear Collider (ILC) have been submitted. Among the three proposals is the International Large Detector (ILD) concept which is at the focus of these studies. From various subjects addressed in the LoI, a wide spectrum of studies of SUSY particle properties is presented here. Most of them are benchmark reactions for the ILC and can be used both in physics studies and in work on detector design and optimization, respectively. All studies were performed with a full detector simulation using GEANT4, which is a great improvement compared to the previous results with much less detailed, so called f ast , simulation (SIMDET). The importance of this improved simulation is reflected in the results. The presented analyzes have been chosen to be the most challenging for the detector to study its performance and guide the detector development. Additionally an important problem of unavoidable beam induced backgrounds at linear colliders is addressed and ways of reducing its impact on physics studies are shown for an example SUSY analysis. (author)

  17. Complementary methods to study glasses and melts at large scale facilities

    International Nuclear Information System (INIS)

    Leydier, M.

    2010-01-01

    In this work, large scale facilities (neutron and synchrotron sources) were used for studying the structure and dynamic of disordered materials (liquids and glasses). In particular, three studies are presented. The first is a structural study of Ln 2 O 3 -Al 2 O 3 -SiO 2 glasses where Ln represents the cations Sc, Y and La. We combined the results obtained from x-ray and neutron diffraction and x-ray absorption experiments. This work is focused on the determination of the interatomic distances and coordination numbers for the three pairs Si-O, Al-O and Ln-O. The second is a study of the iron oxide FeO in the liquid state. Photoemission experiments at the iron absorption edge were associated with x-ray and neutron diffraction measurements. The results obtained made it possible to define a consistent structural model for liquid FeO. The third is a study of the dynamics in CaAl 2 O 4 melts. From inelastic x-ray scattering experiments, it was possible to determine the apparent and isothermal sound velocities as well as the longitudinal viscosity. These measurements were complemented by quasielastic neutron scattering experiments from which atomic diffusion coefficients were determined. This work shows the interest of combining various experimental techniques for studying glasses and melts and points out the need to associate also modelling techniques such as molecular dynamics simulations. (author)

  18. Higher Education Teachers' Descriptions of Their Own Learning: A Large-Scale Study of Finnish Universities of Applied Sciences

    Science.gov (United States)

    Töytäri, Aija; Piirainen, Arja; Tynjälä, Päivi; Vanhanen-Nuutinen, Liisa; Mäki, Kimmo; Ilves, Vesa

    2016-01-01

    In this large-scale study, higher education teachers' descriptions of their own learning were examined with qualitative analysis involving application of principles of phenomenographic research. This study is unique: it is unusual to use large-scale data in qualitative studies. The data were collected through an e-mail survey sent to 5960 teachers…

  19. Anatomically detailed and large-scale simulations studying synapse loss and synchrony using NeuroBox

    Directory of Open Access Journals (Sweden)

    Markus eBreit

    2016-02-01

    Full Text Available The morphology of neurons and networks plays an important role in processing electrical and biochemical signals. Based on neuronal reconstructions, which are becoming abundantly available through databases such as NeuroMorpho.org, numerical simulations of Hodgkin-Huxley-type equations, coupled to biochemical models, can be performed in order to systematically investigate the influence of cellular morphology and the connectivity pattern in networks on the underlying function. Development in the area of synthetic neural network generation and morphology reconstruction from microscopy data has brought forth the software tool NeuGen. Coupling this morphology data (either from databases, synthetic or reconstruction to the simulation platform UG 4 (which harbors a neuroscientific portfolio and VRL-Studio, has brought forth the extendible toolbox NeuroBox. NeuroBox allows users to perform numerical simulations on hybrid-dimensional morphology representations. The code basis is designed in a modular way, such that e.g. new channel or synapse types can be added to the library. Workflows can be specified through scripts or through the VRL-Studio graphical workflow representation. Third-party tools, such as ImageJ, can be added to NeuroBox workflows. In this paper, NeuroBox is used to study the electrical and biochemical effects of synapse loss vs. synchrony in neurons, to investigate large morphology data sets within detailed biophysical simulations, and used to demonstrate the capability of utilizing high-performance computing infrastructure for large scale network simulations. Using new synapse distribution methods and Finite Volume based numerical solvers for compartment-type models, our results demonstrate how an increase in synaptic synchronization can compensate synapse loss at the electrical and calcium level, and how detailed neuronal morphology can be integrated in large-scale network simulations.

  20. Quantifying streamflow change caused by forest disturbance at a large spatial scale: A single watershed study

    Science.gov (United States)

    Wei, Xiaohua; Zhang, Mingfang

    2010-12-01

    Climatic variability and forest disturbance are commonly recognized as two major drivers influencing streamflow change in large-scale forested watersheds. The greatest challenge in evaluating quantitative hydrological effects of forest disturbance is the removal of climatic effect on hydrology. In this paper, a method was designed to quantify respective contributions of large-scale forest disturbance and climatic variability on streamflow using the Willow River watershed (2860 km2) located in the central part of British Columbia, Canada. Long-term (>50 years) data on hydrology, climate, and timber harvesting history represented by equivalent clear-cutting area (ECA) were available to discern climatic and forestry influences on streamflow by three steps. First, effective precipitation, an integrated climatic index, was generated by subtracting evapotranspiration from precipitation. Second, modified double mass curves were developed by plotting accumulated annual streamflow against annual effective precipitation, which presented a much clearer picture of the cumulative effects of forest disturbance on streamflow following removal of climatic influence. The average annual streamflow changes that were attributed to forest disturbances and climatic variability were then estimated to be +58.7 and -72.4 mm, respectively. The positive (increasing) and negative (decreasing) values in streamflow change indicated opposite change directions, which suggest an offsetting effect between forest disturbance and climatic variability in the study watershed. Finally, a multivariate Autoregressive Integrated Moving Average (ARIMA) model was generated to establish quantitative relationships between accumulated annual streamflow deviation attributed to forest disturbances and annual ECA. The model was then used to project streamflow change under various timber harvesting scenarios. The methodology can be effectively applied to any large-scale single watershed where long-term data (>50

  1. Large-volume paracentesis with indwelling peritoneal catheter and albumin infusion: a community hospital study

    Directory of Open Access Journals (Sweden)

    Daniel K. Martin

    2016-10-01

    Full Text Available Background: The management of ascites can be problematic. This is especially true in patients with diuretic refractory ascites who develop a tense abdomen. This often results in hypotension and decreased venous return with resulting renal failure. In this paper, we further examine the risks and benefits of utilizing an indwelling peritoneal catheter to remove large-volume ascites over a 72-h period while maintaining intravascular volume and preventing renal failure. Methods: We retrospectively reviewed charts and identified 36 consecutive patients undergoing continuous large-volume paracentesis with an indwelling peritoneal catheter. At the time of drain placement, no patients had signs or laboratory parameters suggestive of spontaneous bacterial peritonitis. The patients underwent ascitic fluid removal through an indwelling peritoneal catheter and were supported with scheduled albumin throughout the duration. The catheter was used to remove up to 3 L every 8 h for a maximum of 72 h. Regular laboratory and ascitic fluid testing was performed. All patients had a clinical follow-up within 3 months after the drain placement. Results: An average of 16.5 L was removed over the 72-h time frame of indwelling peritoneal catheter maintenance. The albumin infusion utilized correlated to 12 mg/L removed. The average creatinine trend improved in a statistically significant manner from 1.37 on the day of admission to 1.21 on the day of drain removal. No patients developed renal failure during the hospital course. There were no documented episodes of neutrocytic ascites or bacterial peritonitis throughout the study review. Conclusion: Large-volume peritoneal drainage with an indwelling peritoneal catheter is safe and effective for patients with tense ascites. Concomitant albumin infusion allows for maintenance of renal function, and no increase in infectious complications was noted.

  2. Feasibility of a large cohort study in sub-Saharan Africa assessed through a four-country study

    Directory of Open Access Journals (Sweden)

    Shona Dalal

    2015-05-01

    Full Text Available Background: Large prospective epidemiologic studies are vital in determining disease etiology and forming national health policy. Yet, such studies do not exist in sub-Saharan Africa (SSA notwithstanding the growing burden of chronic diseases. Objective: We explored the feasibility of establishing a large-scale multicountry prospective study at five sites in four sub-Saharan countries. Design: Based on country-specific considerations of feasibility, Nigeria enrolled health care professionals, South Africa and Tanzania enrolled teachers, and Uganda enrolled village residents at one rural and one periurban site each. All sites used a 6-month follow-up period but different approaches for data collection, namely standardized questionnaires filled out by participants or face-to-face interviews. Results: We enrolled 1415 participants from five sites (range 200–489 with a median age of 41 years. Approximately half had access to clean-burning cooking fuel and 70% to piped drinking water, yet 92% had access to a mobile phone. The prevalence of chronic diseases was 49% among 45- to 54-year-olds and was dominated by hypertension (21.7% overall – ranging from 4.5 to 31.2% across sites – and a serious injury in the past 12 months (12.4% overall. About 80% of participants indicated willingness to provide blood samples. At 6-month follow-up, 68% completed a questionnaire (45 to 96% across sites with evidence that mobile phones were particularly useful. Conclusions: Our pilot study indicates that a large-scale prospective study in SSA is feasible, and the burden of chronic disease in SSA may already be substantial necessitating urgent etiologic research and primary prevention.

  3. Design, development and characterization studies of a large aperture high power Nd : glass rod amplifier stage

    International Nuclear Information System (INIS)

    Gopi, N.; Bapna, R.C.; Murali, C.G.; Narayan, B.S.; Dhareshwar, L.J.

    1992-01-01

    Laser-plasma interaction studies and experiments related to laser driven shocks as well as laser induced inertially confined thermonuclear fusion have resulted in an ever increasing demand for high brightness lasers capable of producing nanosecond pulse with energy of hundreds of kilo joules. High power Nd-glass laser chains with a master oscillator followed by a number of amplifier stages made up of rods, disks, slabs etc. are in operation in many leading laboratories in the world. This report describes the design, development and characterisation studies of a large aperture Nd:glass laser amplifier which is to be incorporated on line with the existing 40 J, 5 ns high power laser chain built for laser-plasma interaction and laser driven shock wave studies in the Laser and Plasma Technology Division. The development work described in this report discusses the design based on optimum material selection, optimisation of various sub components, ease of maintenance and smooth operation. The necessary operational electronics has also been described. The characterization studies mainly include measurement of spatial gain uniformity, thermally induced depolarization effects, and thermal relaxation studies. (author). 37 refs., 14 figs., 5 tabs

  4. Combined small and large bowel MR imaging in patients with Crohn's disease: a feasibility study

    International Nuclear Information System (INIS)

    Narin, Burcu; Ajaj, Waleed; Goehde, Susanne; Lauenstein, Thomas C.; Langhorst, Jost; Gerken, Guido; Akgoez, Haldun; Ruehm, Stefan G.

    2004-01-01

    MRI of the small bowel is a new method for the assessment of inflammatory bowel diseases. However, inflammatory bowel disease can affect both the small and large bowel. Therefore, our goal was to assess the feasibility of displaying the small bowel and colon simultaneously by MR imaging. Eighteen patients with inflammatory bowel disease were studied. For small bowel distension, patients ingested a solution containing mannitol and locust bean gum. Furthermore, the colon was rectally filled with water. MR examinations were performed on a 1.5-T system. Before and after intravenous gadolinium administration, a T1w data set was collected. All patients underwent conventional colonoscopy as a standard of reference. The oral ingestion and the rectal application of water allowed an assessment of the small bowel and colon in all patients. By means of MRI (endoscopy), 19 (13) inflamed bowel segments in the colon and terminal ileum were detected. Furthermore, eight additional inflammatory lesions in the jejunum and proximal ileum that had not been endoscopically accessible were found by MRI. The simultaneous display of the small and large bowel by MRI is feasible. Major advantages of the proposed MR concept are related to its non-invasive character as well as to the potential to visualize parts of the small bowel that cannot be reached by endoscopy. (orig.)

  5. The application of large amplitude oscillatory stress in a study of fully formed fibrin clots

    Science.gov (United States)

    Lamer, T. F.; Thomas, B. R.; Curtis, D. J.; Badiei, N.; Williams, P. R.; Hawkins, K.

    2017-12-01

    The suitability of controlled stress large amplitude oscillatory shear (LAOStress) for the characterisation of the nonlinear viscoelastic properties of fully formed fibrin clots is investigated. Capturing the rich nonlinear viscoelastic behaviour of the fibrin network is important for understanding the structural behaviour of clots formed in blood vessels which are exposed to a wide range of shear stresses. We report, for the first time, that artefacts due to ringing exist in both the sample stress and strain waveforms of a LAOStress measurement which will lead to errors in the calculation of nonlinear viscoelastic properties. The process of smoothing the waveforms eliminates these artefacts whilst retaining essential rheological information. Furthermore, we demonstrate the potential of LAOStress for characterising the nonlinear viscoelastic properties of fibrin clots in response to incremental increases of applied stress up to the point of fracture. Alternating LAOStress and small amplitude oscillatory shear measurements provide detailed information of reversible and irreversible structural changes of the fibrin clot as a consequence of elevated levels of stress. We relate these findings to previous studies involving large scale deformations of fibrin clots. The LAOStress technique may provide useful information to help understand why some blood clots formed in vessels are stable (such as in deep vein thrombosis) and others break off (leading to a life threatening pulmonary embolism).

  6. Imaging characteristics of supratentorial ependymomas: Study on a large single institutional cohort with histopathological correlation.

    Science.gov (United States)

    Mangalore, Sandhya; Aryan, Saritha; Prasad, Chandrajit; Santosh, Vani

    2015-01-01

    Supratentorial ependymoma (STE) is a tumor whose unique clinical and imaging characteristics have not been studied. Histopathologically, they resemble ependymoma elsewhere. We retrospectively reviewed the imaging findings with clinicopathological correlation in a large number of patients with STE to identify these characteristics. Computed tomography (CT) magnetic resonance images (MRI), pathology reports, and clinical information from 41 patients with pathology-confirmed STE from a single institution were retrospectively reviewed. CT and MRI findings including location, size, signal intensity, hemorrhage, and enhancement pattern were tabulated and described separately in intraventricular and intraparenchymal forms. STE was more common in pediatric age group and intraparenchymal was more common than intraventricular form. The most common presentation was features of raised intracranial tension. There were equal numbers of Grade II and Grade III tumors. The imaging characteristics in adult and pediatric age group were similar. The tumor was large and had both solid and cystic components. Advanced imaging such as diffusion, perfusion, and spectroscopy were suggestive of high-grade tumor. Only differentiating factor between Grade II and Grade III was the presence of calcification. 1234 rule and periwinkle sign which we have described in this article may help characterize this tumor on imaging. This series expands the clinical and imaging spectrum of STE and identifies characteristics that should suggest consideration of this uncommon diagnosis.

  7. Pilot study of large-scale production of mutant pigs by ENU mutagenesis.

    Science.gov (United States)

    Hai, Tang; Cao, Chunwei; Shang, Haitao; Guo, Weiwei; Mu, Yanshuang; Yang, Shulin; Zhang, Ying; Zheng, Qiantao; Zhang, Tao; Wang, Xianlong; Liu, Yu; Kong, Qingran; Li, Kui; Wang, Dayu; Qi, Meng; Hong, Qianlong; Zhang, Rui; Wang, Xiupeng; Jia, Qitao; Wang, Xiao; Qin, Guosong; Li, Yongshun; Luo, Ailing; Jin, Weiwu; Yao, Jing; Huang, Jiaojiao; Zhang, Hongyong; Li, Menghua; Xie, Xiangmo; Zheng, Xuejuan; Guo, Kenan; Wang, Qinghua; Zhang, Shibin; Li, Liang; Xie, Fei; Zhang, Yu; Weng, Xiaogang; Yin, Zhi; Hu, Kui; Cong, Yimei; Zheng, Peng; Zou, Hailong; Xin, Leilei; Xia, Jihan; Ruan, Jinxue; Li, Hegang; Zhao, Weiming; Yuan, Jing; Liu, Zizhan; Gu, Weiwang; Li, Ming; Wang, Yong; Wang, Hongmei; Yang, Shiming; Liu, Zhonghua; Wei, Hong; Zhao, Jianguo; Zhou, Qi; Meng, Anming

    2017-06-22

    N-ethyl-N-nitrosourea (ENU) mutagenesis is a powerful tool to generate mutants on a large scale efficiently, and to discover genes with novel functions at the whole-genome level in Caenorhabditis elegans, flies, zebrafish and mice, but it has never been tried in large model animals. We describe a successful systematic three-generation ENU mutagenesis screening in pigs with the establishment of the Chinese Swine Mutagenesis Consortium. A total of 6,770 G1 and 6,800 G3 pigs were screened, 36 dominant and 91 recessive novel pig families with various phenotypes were established. The causative mutations in 10 mutant families were further mapped. As examples, the mutation of SOX10 (R109W) in pig causes inner ear malfunctions and mimics human Mondini dysplasia, and upregulated expression of FBXO32 is associated with congenital splay legs. This study demonstrates the feasibility of artificial random mutagenesis in pigs and opens an avenue for generating a reservoir of mutants for agricultural production and biomedical research.

  8. A method for generating large datasets of organ geometries for radiotherapy treatment planning studies

    International Nuclear Information System (INIS)

    Hu, Nan; Cerviño, Laura; Segars, Paul; Lewis, John; Shan, Jinlu; Jiang, Steve; Zheng, Xiaolin; Wang, Ge

    2014-01-01

    With the rapidly increasing application of adaptive radiotherapy, large datasets of organ geometries based on the patient’s anatomy are desired to support clinical application or research work, such as image segmentation, re-planning, and organ deformation analysis. Sometimes only limited datasets are available in clinical practice. In this study, we propose a new method to generate large datasets of organ geometries to be utilized in adaptive radiotherapy. Given a training dataset of organ shapes derived from daily cone-beam CT, we align them into a common coordinate frame and select one of the training surfaces as reference surface. A statistical shape model of organs was constructed, based on the establishment of point correspondence between surfaces and non-uniform rational B-spline (NURBS) representation. A principal component analysis is performed on the sampled surface points to capture the major variation modes of each organ. A set of principal components and their respective coefficients, which represent organ surface deformation, were obtained, and a statistical analysis of the coefficients was performed. New sets of statistically equivalent coefficients can be constructed and assigned to the principal components, resulting in a larger geometry dataset for the patient’s organs. These generated organ geometries are realistic and statistically representative

  9. EUPAN enables pan-genome studies of a large number of eukaryotic genomes.

    Science.gov (United States)

    Hu, Zhiqiang; Sun, Chen; Lu, Kuang-Chen; Chu, Xixia; Zhao, Yue; Lu, Jinyuan; Shi, Jianxin; Wei, Chaochun

    2017-08-01

    Pan-genome analyses are routinely carried out for bacteria to interpret the within-species gene presence/absence variations (PAVs). However, pan-genome analyses are rare for eukaryotes due to the large sizes and higher complexities of their genomes. Here we proposed EUPAN, a eukaryotic pan-genome analysis toolkit, enabling automatic large-scale eukaryotic pan-genome analyses and detection of gene PAVs at a relatively low sequencing depth. In the previous studies, we demonstrated the effectiveness and high accuracy of EUPAN in the pan-genome analysis of 453 rice genomes, in which we also revealed widespread gene PAVs among individual rice genomes. Moreover, EUPAN can be directly applied to the current re-sequencing projects primarily focusing on single nucleotide polymorphisms. EUPAN is implemented in Perl, R and C ++. It is supported under Linux and preferred for a computer cluster with LSF and SLURM job scheduling system. EUPAN together with its standard operating procedure (SOP) is freely available for non-commercial use (CC BY-NC 4.0) at http://cgm.sjtu.edu.cn/eupan/index.html . ccwei@sjtu.edu.cn or jianxin.shi@sjtu.edu.cn. Supplementary data are available at Bioinformatics online. © The Author (2017). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com

  10. Vulnerability of Eastern Caribbean Islands Economies to Large Earthquakes: The Trinidad and Tobago Case Study

    Science.gov (United States)

    Lynch, L.

    2015-12-01

    The economies of most of the Anglo-phone Eastern Caribbean islands have tripled to quadrupled in size since independence from England. There has also been commensurate growth in human and physical development as indicated by macro-economic indices such as Human Development Index and Fixed Capital Formation. A significant proportion of the accumulated wealth is invested in buildings and infrastructure which are highly susceptible to strong ground motion since the region is located along an active plate boundary. In the case of Trinidad and Tobago, Fixed Capital Formation accumulation since 1980 is almost US200 billion dollars. Recent studies have indicated that this twin island state is at significant risk from several seismic sources, both on land and offshore. To effectively mitigate the risk it is necessary to prescribe long-term measures such as the development and implementation of building code and standards, structural retrofitting, land use planning, preparedness planning and risk transfer mechanisms. The record has shown that Trinidad and Tobago has been been slow in the prescribing such measures which has consequently compounded it vulnerability to large earthquakes. This assessment reveals that the losses from a large (magnitude 7+) on land or an extreme (magnitude 8+) event could result in losses of up to US28B and that current risk transfer measures will only cater for less than ten percent of such losses.

  11. Study of large size fiber reinforced cement containers for solid wastes from dismantling

    International Nuclear Information System (INIS)

    Jaouen, C.

    1990-01-01

    The production of large-sized metallic waste by dismantling operations, and the evolution of the specifications of the waste to be stored in the different European countries will create a need for large standard containers for the transport and final disposal of the corresponding waste. The research conducted during the 1984-1988 programme, supported by the Commission of European Communities, and based on a comparative study of high-grade concrete materials, reinforced with organic or metallic fibres, led to the development of a high performance container meeting international transport recommendations as well as French requirements for shallow-ground disposal. The material selected, consisting of high-performance mortar with metal fibre reinforcement, was the subject of an intensive programme of characterization tests conducted in close cooperation with LAFARGE Company, demonstrating the achievement of mechanical and physical properties comfortably above the regulatory requirements. The construction of an industrial prototype and the subsequent economic analysis served to guarantee the industrial feasibility and cost of this system, in which attempts were made to optimize the finished package product, including its closure system

  12. Benchmarking study and its application for shielding analysis of large accelerator facilities

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Hee-Seock; Kim, Dong-hyun; Oranj, Leila Mokhtari; Oh, Joo-Hee; Lee, Arim; Jung, Nam-Suk [POSTECH, Pohang (Korea, Republic of)

    2015-10-15

    Shielding Analysis is one of subjects which are indispensable to construct large accelerator facility. Several methods, such as the Monte Carlo, discrete ordinate, and simplified calculation, have been used for this purpose. The calculation precision is overcome by increasing the trial (history) numbers. However its accuracy is still a big issue in the shielding analysis. To secure the accuracy in the Monte Carlo calculation, the benchmarking study using experimental data and the code comparison are adopted fundamentally. In this paper, the benchmarking result for electrons, protons, and heavy ions are presented as well as the proper application of the results is discussed. The benchmarking calculations, which are indispensable in the shielding analysis were performed for different particles: proton, heavy ion and electron. Four different multi-particle Monte Carlo codes, MCNPX, FLUKA, PHITS, and MARS, were examined for higher energy range equivalent to large accelerator facility. The degree of agreement between the experimental data including the SINBAD database and the calculated results were estimated in the terms of secondary neutron production and attenuation through the concrete and iron shields. The degree of discrepancy and the features of Monte Carlo codes were investigated and the application way of the benchmarking results are discussed in the view of safety margin and selecting the code for the shielding analysis. In most cases, the tested Monte Carlo codes give proper credible results except of a few limitation of each codes.

  13. Benchmarking study and its application for shielding analysis of large accelerator facilities

    International Nuclear Information System (INIS)

    Lee, Hee-Seock; Kim, Dong-hyun; Oranj, Leila Mokhtari; Oh, Joo-Hee; Lee, Arim; Jung, Nam-Suk

    2015-01-01

    Shielding Analysis is one of subjects which are indispensable to construct large accelerator facility. Several methods, such as the Monte Carlo, discrete ordinate, and simplified calculation, have been used for this purpose. The calculation precision is overcome by increasing the trial (history) numbers. However its accuracy is still a big issue in the shielding analysis. To secure the accuracy in the Monte Carlo calculation, the benchmarking study using experimental data and the code comparison are adopted fundamentally. In this paper, the benchmarking result for electrons, protons, and heavy ions are presented as well as the proper application of the results is discussed. The benchmarking calculations, which are indispensable in the shielding analysis were performed for different particles: proton, heavy ion and electron. Four different multi-particle Monte Carlo codes, MCNPX, FLUKA, PHITS, and MARS, were examined for higher energy range equivalent to large accelerator facility. The degree of agreement between the experimental data including the SINBAD database and the calculated results were estimated in the terms of secondary neutron production and attenuation through the concrete and iron shields. The degree of discrepancy and the features of Monte Carlo codes were investigated and the application way of the benchmarking results are discussed in the view of safety margin and selecting the code for the shielding analysis. In most cases, the tested Monte Carlo codes give proper credible results except of a few limitation of each codes

  14. AN INSECURE WILD WEB: A LARGE-SCALE STUDY OF EFFECTIVENESS OF WEB SECURITY MECHANISMS

    Directory of Open Access Journals (Sweden)

    Kailas Patil

    2017-03-01

    Full Text Available This research work presents a large-scale study of the problems in real-world web applications and widely-used mobile browsers. Through a large-scale experiment, we find inconsistencies in Secure Socket Layer (SSL warnings among popular mobile web browsers (over a billion users download. The majority of popular mobile browsers on the Google Play Store either provide incomplete information in SSL warnings shown to users or failed to provide SSL warnings in the presence of security certificate errors, thus making it a difficult task even for a security savvy user to make an informed decision. In addition, we find that 28% of websites are using mixed content. Mixed content means a secure website (https loads a sub resource using insecure HTTP protocol. The mixed content weakens the security of entire website and vulnerable to man-in-the-middle (MITM attacks. Furthermore, we inspected the default behavior of mobile web browsers and report that majority of mobile web browsers allow execution of mixed content in web applications, which implies billions of mobile browser users are vulnerable to eavesdropping and MITM attacks. Based on our findings, we make recommendations for website developers, users and browser vendors.

  15. Characterizing the spatial variations and correlations of large rainstorms for landslide study

    Directory of Open Access Journals (Sweden)

    L. Gao

    2017-09-01

    Full Text Available Rainfall is the primary trigger of landslides in Hong Kong; hence, rainstorm spatial distribution is an important piece of information in landslide hazard analysis. The primary objective of this paper is to quantify spatial correlation characteristics of three landslide-triggering large storms in Hong Kong. The spatial maximum rolling rainfall is represented by a rotated ellipsoid trend surface and a random field of residuals. The maximum rolling 4, 12, 24, and 36 h rainfall amounts of these storms are assessed via surface trend fitting, and the spatial correlation of the detrended residuals is determined through studying the scales of fluctuation along eight directions. The principal directions of the surface trend are between 19 and 43°, and the major and minor axis lengths are 83–386 and 55–79 km, respectively. The scales of fluctuation of the residuals are found between 5 and 30 km. The spatial distribution parameters for the three large rainstorms are found to be similar to those for four ordinary rainfall events. The proposed rainfall spatial distribution model and parameters help define the impact area, rainfall intensity and local topographic effects for landslide hazard evaluation in the future.

  16. Weather and headache onset: a large-scale study of headache medicine purchases

    Science.gov (United States)

    Ozeki, Kayoko; Noda, Tatsuya; Nakamura, Mieko; Ojima, Toshiyuki

    2015-04-01

    It is widely recognized that weather changes can trigger headache onset. Most people who develop headaches choose to self-medicate rather than visit a hospital or clinic. We investigated the association between weather and headache onset using large-sample sales of the headache medicine, loxoprofen. We collected daily sales figures of loxoprofen and over-the-counter drugs over a 1-year period from a drugstore chain in western Shizuoka prefecture, Japan. To adjust for changes in daily sales of loxoprofen due to social environmental factors, we calculated a proportion of loxoprofen daily sales to over-the-counter drug daily sales. At the same time, we obtained weather data for the study region from the website of the Japan Meteorological Agency. We performed linear regression analysis to ascertain the association between weather conditions and the loxoprofen daily sales proportion. We also conducted a separate questionnaire survey at the same drugstores to determine the reason why people purchased loxoprofen. Over the study period, we surveyed the sale of hundreds of thousands of loxoprofen tablets. Most people purchased loxoprofen because they had a headache. We found that the sales proportion of loxoprofen increased when average barometric pressure decreased, and that precipitation, average humidity, and minimum humidity increased on loxoprofen purchase days compared to the previous day of purchases. This study, performed using a large dataset that was easy-to-collect and representative of the general population, revealed that sales of loxoprofen, which can represent the onset and aggravation of headache, significantly increased with worsening weather conditions.

  17. Effect of maternal age on the risk of preterm birth: A large cohort study.

    Science.gov (United States)

    Fuchs, Florent; Monet, Barbara; Ducruet, Thierry; Chaillet, Nils; Audibert, Francois

    2018-01-01

    Maternal age at pregnancy is increasing worldwide as well as preterm birth. However, the association between prematurity and advanced maternal age remains controversial. To evaluate the impact of maternal age on the occurrence of preterm birth after controlling for multiple known confounders in a large birth cohort. Retrospective cohort study using data from the QUARISMA study, a large Canadian randomized controlled trial, which collected data from 184,000 births in 32 hospitals. Inclusion criteria were maternal age over 20 years. Exclusion criteria were multiple pregnancy, fetal malformation and intra-uterine fetal death. Five maternal age categories were defined and compared for maternal characteristics, gestational and obstetric complications, and risk factors for prematurity. Risk factors for preterm birth births were included in the study. Chronic hypertension, assisted reproduction techniques, pre-gestational diabetes, invasive procedure in pregnancy, gestational diabetes and placenta praevia were linearly associated with increasing maternal age whereas hypertensive disorders of pregnancy followed a "U" shaped distribution according to maternal age. Crude rates of preterm birth before 37 weeks followed a "U" shaped curve with a nadir at 5.7% for the group of 30-34 years. In multivariate analysis, the adjusted odds ratio (aOR) of prematurity stratified by age group followed a "U" shaped distribution with an aOR of 1.08 (95%CI; 1.01-1.15) for 20-24 years, and 1.20 (95% CI; 1.06-1.36) for 40 years and older. Confounders found to have the greatest impact were placenta praevia, hypertensive complications, and maternal medical history. Even after adjustment for confounders, advanced maternal age (40 years and over) was associated with preterm birth. A maternal age of 30-34 years was associated with the lowest risk of prematurity.

  18. 3D fully convolutional networks for subcortical segmentation in MRI: A large-scale study.

    Science.gov (United States)

    Dolz, Jose; Desrosiers, Christian; Ben Ayed, Ismail

    2018-04-15

    This study investigates a 3D and fully convolutional neural network (CNN) for subcortical brain structure segmentation in MRI. 3D CNN architectures have been generally avoided due to their computational and memory requirements during inference. We address the problem via small kernels, allowing deeper architectures. We further model both local and global context by embedding intermediate-layer outputs in the final prediction, which encourages consistency between features extracted at different scales and embeds fine-grained information directly in the segmentation process. Our model is efficiently trained end-to-end on a graphics processing unit (GPU), in a single stage, exploiting the dense inference capabilities of fully CNNs. We performed comprehensive experiments over two publicly available datasets. First, we demonstrate a state-of-the-art performance on the ISBR dataset. Then, we report a large-scale multi-site evaluation over 1112 unregistered subject datasets acquired from 17 different sites (ABIDE dataset), with ages ranging from 7 to 64 years, showing that our method is robust to various acquisition protocols, demographics and clinical factors. Our method yielded segmentations that are highly consistent with a standard atlas-based approach, while running in a fraction of the time needed by atlas-based methods and avoiding registration/normalization steps. This makes it convenient for massive multi-site neuroanatomical imaging studies. To the best of our knowledge, our work is the first to study subcortical structure segmentation on such large-scale and heterogeneous data. Copyright © 2017 Elsevier Inc. All rights reserved.

  19. An Annual Report to the Legislature on Oregon Public Schools. Oregon Statewide Report Card. 2014-2015

    Science.gov (United States)

    Oregon Department of Education, 2015

    2015-01-01

    The Oregon Statewide Report Card is an annual publication required by law (ORS 329.115), which reports on the state of public schools and their progress towards the goals of the Oregon Educational Act for the 21st Century. The purpose of the Oregon Report Card is to monitor trends among school districts and Oregon's progress toward achieving the…

  20. Changes in Obesity Awareness, Obesity Identification, and Self-Assessment of Health: Results from a Statewide Public Education Campaign

    Science.gov (United States)

    Tsai, Adam G.; Boyle, Tracy F.; Hill, James O.; Lindley, Corina; Weiss, Karl

    2014-01-01

    Background: Due to the high prevalence of obesity, individuals may be desensitized to weight as a personal health concern. Purpose: To evaluate changes in obesity awareness associated with a statewide public education campaign in Colorado. Methods: Cross-sectional random digit dial telephone surveys (n = 1,107 pre, n = 1101 post) were conducted…

  1. Results from a Multi-Modal Program Evaluation of a Four Year Statewide Juvenile Sex Offender Treatment and Reentry Program

    Science.gov (United States)

    Underwood, Lee A.; Dailey, Frances L. L.; Merino, Carrie; Crump, Yolanda

    2015-01-01

    The results of the Program Evaluation show the OJJ Statewide Sex Offender Treatment program is exceptionally productive in meeting over 90% of its established performance markers. These markers included successful screening and assessment of risk and psychosocial needs, completion of initial and master treatment plans, establishment of sex…

  2. Filling the Void: The Roles of a Local Applied Research Center and a Statewide Workforce Training Consortium

    Science.gov (United States)

    Perniciaro, Richard C.; Nespoli, Lawrence A.; Anbarasan, Sivaraman

    2015-01-01

    This chapter describes the development of an applied research center at Atlantic Cape Community College and a statewide workforce training consortium run by the community college sector in New Jersey. Their contributions to the economic development mission of the colleges as well as their impact on the perception of community colleges by…

  3. A Guide to Effective Statewide Laws/Policies: Preventing Discrimination against LGBT Students in K-12 Schools.

    Science.gov (United States)

    Lambda Legal Defense and Education Fund, New York, NY.

    This document presents guidance for stopping discrimination, harassment, and violence against lesbian, gay, bisexual, and transgender (LGBT) students in schools. Section 1, "Lambda Legal Defense and Education Fund on the Legal Considerations for Creating and Changing Statewide Laws and Policies," discusses the various types of statewide…

  4. Under Pressure: Financial Effect of the Hospital-Acquired Conditions Initiative-A Statewide Analysis of Pressure Ulcer Development and Payment.

    Science.gov (United States)

    Meddings, Jennifer; Reichert, Heidi; Rogers, Mary A M; Hofer, Timothy P; McMahon, Laurence F; Grazier, Kyle L

    2015-07-01

    To assess the financial effect of the 2008 Hospital-Acquired Conditions Initiative (HACI) pressure ulcer payment changes on Medicare, other payers, and hospitals. Retrospective before-and-after study of all-payer statewide administrative data for more than 2.4 million annual adult discharges in 2007 and 2009 using the Healthcare Cost and Utilization Project State Inpatient Datasets for California. How often and by how much the 2008 payment changes for pressure ulcers affected hospital payment was assessed. Nonfederal acute care California hospitals (N = 311). Adults discharged from acute-care hospitals. Pressure ulcer rates and hospital payment changes. Hospital-acquired pressure ulcer rates were low in 2007 (0.28%) and 2009 (0.27%); present-on-admission pressure ulcer rates increased from 2.3% in 2007 to 3.0% in 2009. According to clinical stage of pressure ulcer (available in 2009), hospital-acquired Stage III and IV ulcers occurred in 603 discharges (0.02%); 60,244 discharges (2.42%) contained other pressure ulcer diagnoses. Payment removal for Stage III and IV hospital-acquired ulcers reduced payment in 75 (0.003%) discharges, for a statewide payment decrease of $310,444 (0.001%) for all payers and $199,238 (0.001%) for Medicare. For all other pressure ulcers, the Hospital-Acquired Conditions Initiative reduced hospital payment in 20,246 (0.81%) cases (including 18,953 cases with present-on-admission ulcers), reducing statewide payment by $62,538,586 (0.21%) for all payers and $47,237,984 (0.32%) for Medicare. The total financial effect of the 2008 payment changes for pressure ulcers was negligible. Most payment decreases occurred by removal of comorbidity payments for present-on-admission pressure ulcers other than Stages III and IV. The removal of payment for hospital-acquired Stage III and IV ulcers by implementation of the HACI policy was 1/200th that of the removal of payment for other types of pressure ulcers that occurred in implementation of the

  5. Large-scale coherent structures of suspended dust concentration in the neutral atmospheric surface layer: A large-eddy simulation study

    Science.gov (United States)

    Zhang, Yangyue; Hu, Ruifeng; Zheng, Xiaojing

    2018-04-01

    Dust particles can remain suspended in the atmospheric boundary layer, motions of which are primarily determined by turbulent diffusion and gravitational settling. Little is known about the spatial organizations of suspended dust concentration and how turbulent coherent motions contribute to the vertical transport of dust particles. Numerous studies in recent years have revealed that large- and very-large-scale motions in the logarithmic region of laboratory-scale turbulent boundary layers also exist in the high Reynolds number atmospheric boundary layer, but their influence on dust transport is still unclear. In this study, numerical simulations of dust transport in a neutral atmospheric boundary layer based on an Eulerian modeling approach and large-eddy simulation technique are performed to investigate the coherent structures of dust concentration. The instantaneous fields confirm the existence of very long meandering streaks of dust concentration, with alternating high- and low-concentration regions. A strong negative correlation between the streamwise velocity and concentration and a mild positive correlation between the vertical velocity and concentration are observed. The spatial length scales and inclination angles of concentration structures are determined, compared with their flow counterparts. The conditionally averaged fields vividly depict that high- and low-concentration events are accompanied by a pair of counter-rotating quasi-streamwise vortices, with a downwash inside the low-concentration region and an upwash inside the high-concentration region. Through the quadrant analysis, it is indicated that the vertical dust transport is closely related to the large-scale roll modes, and ejections in high-concentration regions are the major mechanisms for the upward motions of dust particles.

  6. Statistical Analysis of Large Simulated Yield Datasets for Studying Climate Effects

    Science.gov (United States)

    Makowski, David; Asseng, Senthold; Ewert, Frank; Bassu, Simona; Durand, Jean-Louis; Martre, Pierre; Adam, Myriam; Aggarwal, Pramod K.; Angulo, Carlos; Baron, Chritian; hide

    2015-01-01

    Many studies have been carried out during the last decade to study the effect of climate change on crop yields and other key crop characteristics. In these studies, one or several crop models were used to simulate crop growth and development for different climate scenarios that correspond to different projections of atmospheric CO2 concentration, temperature, and rainfall changes (Semenov et al., 1996; Tubiello and Ewert, 2002; White et al., 2011). The Agricultural Model Intercomparison and Improvement Project (AgMIP; Rosenzweig et al., 2013) builds on these studies with the goal of using an ensemble of multiple crop models in order to assess effects of climate change scenarios for several crops in contrasting environments. These studies generate large datasets, including thousands of simulated crop yield data. They include series of yield values obtained by combining several crop models with different climate scenarios that are defined by several climatic variables (temperature, CO2, rainfall, etc.). Such datasets potentially provide useful information on the possible effects of different climate change scenarios on crop yields. However, it is sometimes difficult to analyze these datasets and to summarize them in a useful way due to their structural complexity; simulated yield data can differ among contrasting climate scenarios, sites, and crop models. Another issue is that it is not straightforward to extrapolate the results obtained for the scenarios to alternative climate change scenarios not initially included in the simulation protocols. Additional dynamic crop model simulations for new climate change scenarios are an option but this approach is costly, especially when a large number of crop models are used to generate the simulated data, as in AgMIP. Statistical models have been used to analyze responses of measured yield data to climate variables in past studies (Lobell et al., 2011), but the use of a statistical model to analyze yields simulated by complex

  7. Correction of population stratification in large multi-ethnic association studies.

    Directory of Open Access Journals (Sweden)

    David Serre

    2008-01-01

    Full Text Available The vast majority of genetic risk factors for complex diseases have, taken individually, a small effect on the end phenotype. Population-based association studies therefore need very large sample sizes to detect significant differences between affected and non-affected individuals. Including thousands of affected individuals in a study requires recruitment in numerous centers, possibly from different geographic regions. Unfortunately such a recruitment strategy is likely to complicate the study design and to generate concerns regarding population stratification.We analyzed 9,751 individuals representing three main ethnic groups - Europeans, Arabs and South Asians - that had been enrolled from 154 centers involving 52 countries for a global case/control study of acute myocardial infarction. All individuals were genotyped at 103 candidate genes using 1,536 SNPs selected with a tagging strategy that captures most of the genetic diversity in different populations. We show that relying solely on self-reported ethnicity is not sufficient to exclude population stratification and we present additional methods to identify and correct for stratification.Our results highlight the importance of carefully addressing population stratification and of carefully "cleaning" the sample prior to analyses to obtain stronger signals of association and to avoid spurious results.

  8. Conceptual study of calibration software for large scale input accountancy tank

    International Nuclear Information System (INIS)

    Uchikoshi, Seiji; Yasu, Kan-ichi; Watanabe, Yuichi; Matsuda, Yuji; Kawai, Akio; Tamura, Toshiyuki; Shimizu, Hidehiko.

    1996-01-01

    Demonstration experiments for large scale input accountancy tank are going to be under way by Nuclear Material Control Center. Development of calibration software for accountancy system with dip-tube manometer is an important task in the experiments. A conceptual study of the software has been carried out to construct high precision accountancy system. And, the study was based on ANSI N15.19-1989. Items of the study are overall configuration, correction method for influence of bubble formation, function model of calibration, and fitting method for calibration curve. Following remarks are the results of this study. 1) Overall configuration of the software was constructed. 2) It was shown by numerical solution, that the influence of bubble formation can be corrected using period of pressure wave. 3) Two function models of calibration for well capacity and for inner structure volume were prepared from tank design, and good fitness of the model for net capacity (balance of both models) was confirmed by fitting to designed shape of the tank. 4) The necessity of further consideration about both-variables-in-error-model and cumulative-error-model was recognized. We are going to develop a practical software on the basis of the results, and to verify it by the demonstration experiments. (author)

  9. Integration in New Product Development: Case Study in a Large Brazilian

    Directory of Open Access Journals (Sweden)

    Daniel Jugend

    2012-02-01

    Full Text Available Proficiency in management activities undertaken in product development processes is regarded as a key competitive advantage for companies, particularly for high-tech industrial firms, which benefit from the important competitiveness factor of launching products with a differentiated technological content. This paper’s objective was to identify, through case study, practices for integration between the roles of R & D with others involved in product development in a large Brazilian company of industrial automation. The results suggest some management practices to improve the integration in new products development, such as the use of employees from marketing with knowledge and experience previously gained from R & D activities and uses the heavyweight product manager to solve synchronization problems between product and technology development.

  10. Study of heat treatment parameters for large-scale hydraulic steel gate track

    Directory of Open Access Journals (Sweden)

    Ping-zhou Cao

    2013-10-01

    Full Text Available In order to enhance external hardness and strength, a large-scale hydraulic gate track should go through heat treatment. The current design method of hydraulic gate wheels and tracks is based on Hertz contact linear elastic theory, and does not take into account the changes in mechanical properties of materials caused by heat treatment. In this study, the heat treatment parameters were designed and analyzed according to the bearing mechanisms of the wheel and track. The quenching process of the track was simulated by the ANSYS program, and the temperature variation, residual stress, and deformation were obtained and analyzed. The metallurgical structure field after heat treatment was predicted by the method based on time-temperature-transformation (TTT curves. The results show that the analysis method and designed track heat treatment process are feasible, and can provide a reference for practical projects.

  11. Large scale breeder reactor plant prototype mechanical pump conceptual design study

    Energy Technology Data Exchange (ETDEWEB)

    1976-07-01

    This report includes engineering memorandums, drawings, key feature descriptions, and other data. Some of the reports, such as manufacturability and some stress analysis, were done by consultants for Byron Jackson. Review of this report indicates that the design is feasible. The pump can be manufactured to system and specification requirements. The overall length and weight of some pieces will require special consideration, but is within the scope of equipment and technology available today. The fabricated parts are large and heavy, but can be manufactured and machined. Only the high temperature is unique to this size, since previous sodium pumps were smaller. Nondestructive tests as required by the Code are described and are feasible. The performance test of the prototype has been studied thoroughly. It is feasible for a cold water test. There are some problem areas. However, all of them can be solved. Development needs include building and testing a small scale model.

  12. Large thermoelectric efficiency of doped polythiophene junction: A density functional study

    Science.gov (United States)

    Golsanamlou, Zahra; Bagheri Tagani, Meysam; Rahimpour Soleimani, Hamid

    2018-06-01

    The thermoelectric properties of polythiophene (PT) coupled to the Au (111) electrodes are studied based on density functional theory with nonequilibrium Green function formalism. Specially, the effect of Li and Cl adsorbents on the thermoelectric efficiency of the PT junction is investigated in different concentrations of the dopants for two lengths of the PT. Results show that the presence of dopants can bring the structural changes in the oligomer and modify the arrangement of the molecular levels leading to the dramatic changes in the transmission spectra of the junction. Therefore, the large enhancement in thermopower and consequently figure of merit is obtained by dopants which makes the doped PT junction as a beneficial thermoelectric device.

  13. Large-Scale True Triaxial Apparatus for Geophysical Studies in Fractured Rock

    KAUST Repository

    Garcia, A. V.

    2018-05-12

    The study of fractured rock masses in the laboratory remains challenging because of the large specimen sizes and bulky loading systems that are required. This article presents the design, structural analysis, and operation of a compact and self-reacting true triaxial device for fractured rock. The frame subjects a 50 cm by 50 cm by 50 cm fractured rock specimen to a maximum stress of 3 MPa along three independent axes. Concurrent measurements include long-wavelength P-wave propagation, passive acoustic emission monitoring, deformations, and thermal measurements. The device can accommodate diverse research, from rock mass properties and geophysical fractured rock characterizations, to coupled hydro-chemo-thermo-mechanical processes, drilling, and grouting. Preliminary wave propagation data gathered under isotropic and anisotropic stress conditions for an assembly of 4,000 rock blocks demonstrate the system’s versatility and provide unprecedented information related to long-wavelength propagation in fractured rock under various stress anisotropies.

  14. Modelling large motion events in fMRI studies of patients with epilepsy

    DEFF Research Database (Denmark)

    Lemieux, Louis; Salek-Haddadi, Afraim; Lund, Torben E

    2007-01-01

    -positive activation. Head motion can lead to severe image degradation and result in false-positive activation and is usually worse in patients than in healthy subjects. We performed general linear model fMRI data analysis on simultaneous EEG-fMRI data acquired in 34 cases with focal epilepsy. Signal changes...... associated with large inter-scan motion events (head jerks) were modelled using modified design matrices that include 'scan nulling' regressors. We evaluated the efficacy of this approach by mapping the proportion of the brain for which F-tests across the additional regressors were significant. In 95......% of cases, there was a significant effect of motion in 50% of the brain or greater; for the scan nulling effect, the proportion was 36%; this effect was predominantly in the neocortex. We conclude that careful consideration of the motion-related effects in fMRI studies of patients with epilepsy is essential...

  15. Large-Scale True Triaxial Apparatus for Geophysical Studies in Fractured Rock

    KAUST Repository

    Garcia, A. V.; Rached, R. M.; Santamarina, Carlos

    2018-01-01

    The study of fractured rock masses in the laboratory remains challenging because of the large specimen sizes and bulky loading systems that are required. This article presents the design, structural analysis, and operation of a compact and self-reacting true triaxial device for fractured rock. The frame subjects a 50 cm by 50 cm by 50 cm fractured rock specimen to a maximum stress of 3 MPa along three independent axes. Concurrent measurements include long-wavelength P-wave propagation, passive acoustic emission monitoring, deformations, and thermal measurements. The device can accommodate diverse research, from rock mass properties and geophysical fractured rock characterizations, to coupled hydro-chemo-thermo-mechanical processes, drilling, and grouting. Preliminary wave propagation data gathered under isotropic and anisotropic stress conditions for an assembly of 4,000 rock blocks demonstrate the system’s versatility and provide unprecedented information related to long-wavelength propagation in fractured rock under various stress anisotropies.

  16. SPECTROSCOPIC STUDY OF THE N159/N160 COMPLEX IN THE LARGE MAGELLANIC CLOUD

    International Nuclear Information System (INIS)

    Farina, Cecilia; Bosch, Guillermo L.; Morrell, Nidia I.; Barba, Rodolfo H.; Walborn, Nolan R.

    2009-01-01

    We present a spectroscopic study of the N159/N160 massive star-forming region south of 30 Doradus in the Large Magellanic Cloud, classifying a total of 189 stars in the field of the complex. Most of them belong to O and early B spectral classes; we have also found some uncommon and very interesting spectra, including members of the Onfp class, a Be P Cygni star, and some possible multiple systems. Using spectral types as broad indicators of evolutionary stages, we considered the evolutionary status of the region as a whole. We infer that massive stars at different evolutionary stages are present throughout the region, favoring the idea of a common time for the origin of recent star formation in the N159/N160 complex as a whole, while sequential star formation at different rates is probably present in several subregions.

  17. Study on growth techniques and macro defects of large-size Nd:YAG laser crystal

    Science.gov (United States)

    Quan, Jiliang; Yang, Xin; Yang, Mingming; Ma, Decai; Huang, Jinqiang; Zhu, Yunzhong; Wang, Biao

    2018-02-01

    Large-size neodymium-doped yttrium aluminum garnet (Nd:YAG) single crystals were grown by the Czochralski method. The extinction ratio and wavefront distortion of the crystal were tested to determine the optical homogeneity. Moreover, under different growth conditions, the macro defects of inclusion, striations, and cracking in the as-grown Nd:YAG crystals were analyzed. Specifically, the inclusion defects were characterized using scanning electron microscopy and energy dispersive spectroscopy. The stresses of growth striations and cracking were studied via a parallel plane polariscope. These results demonstrate that improper growth parameters and temperature fields can enhance defects significantly. Thus, by adjusting the growth parameters and optimizing the thermal environment, high-optical-quality Nd:YAG crystals with a diameter of 80 mm and a total length of 400 mm have been obtained successfully.

  18. A large-scale molecular dynamics study of the divacancy defect in graphene

    International Nuclear Information System (INIS)

    Leyssale, Jean-Marc; Vignoles, Gerard L.

    2014-01-01

    We report on the dynamical behavior of single divacancy defects in large graphene sheets as studied by extensive classical molecular dynamics (MD) simulations at high temperatures and static calculations. In the first part of the paper, the ability of the used interatomic potential to properly render the stability and dynamics (energy barriers) of such defects is validated against electronic structure calculations from the literature. Then, results from MD simulations are presented. In agreement with recent TEM studies, some mobility is observed through a series of Stone-Wales-like bond rotations involving the 5-8-5, 555-777, and 5555-6-7777 reconstructions. Although these three structures are by far the most probable structures of the DV defect, not less than 18 other full reconstructions, including the experimentally observed 55-66-77 defect, were occasionally observed in the ∼1.5 μs of MD trajectories analyzed in this work. Most of these additional reconstructions have moderate formation energies and can be formed by a bond rotation mechanism from one of the aforementioned structures, with a lower activation energy than the one required to form a Stone-Wales defect in graphene. Therefore their future experimental observation is highly probable. The results presented here also suggest that the barrier to a conventional Stone-Wales transformation (the formation of two pentagon/heptagon pairs from four hexagons) can be significantly reduced in the vicinity of an existing defect, strengthening a recently proposed melting mechanism for graphene based on the aggregation of Stone-Wales defects. From a structural point of view, in addition to pentagons, heptagons, and octagons, these new DV reconstructions can also contain four- and nine-member rings and show a particularly large spatial extent of up to 13 rings (42 atoms) against three (14 atoms) for the original 5-8-5 defect. (authors)

  19. Ethical dilemmas of a large national multi-centre study in Australia: time for some consistency.

    Science.gov (United States)

    Driscoll, Andrea; Currey, Judy; Worrall-Carter, Linda; Stewart, Simon

    2008-08-01

    To examine the impact and obstacles that individual Institutional Research Ethics Committee (IRECs) had on a large-scale national multi-centre clinical audit called the National Benchmarks and Evidence-based National Clinical guidelines for Heart failure management programmes Study. Multi-centre research is commonplace in the health care system. However, IRECs continue to fail to differentiate between research and quality audit projects. The National Benchmarks and Evidence-based National Clinical guidelines for Heart failure management programmes study used an investigator-developed questionnaire concerning a clinical audit for heart failure programmes throughout Australia. Ethical guidelines developed by the National governing body of health and medical research in Australia classified the National Benchmarks and Evidence-based National Clinical guidelines for Heart failure management programmes Study as a low risk clinical audit not requiring ethical approval by IREC. Fifteen of 27 IRECs stipulated that the research proposal undergo full ethical review. None of the IRECs acknowledged: national quality assurance guidelines and recommendations nor ethics approval from other IRECs. Twelve of the 15 IRECs used different ethics application forms. Variability in the type of amendments was prolific. Lack of uniformity in ethical review processes resulted in a six- to eight-month delay in commencing the national study. Development of a national ethics application form with full ethical review by the first IREC and compulsory expedited review by subsequent IRECs would resolve issues raised in this paper. IRECs must change their ethics approval processes to one that enhances facilitation of multi-centre research which is now normative process for health services. The findings of this study highlight inconsistent ethical requirements between different IRECs. Also highlighted are the obstacles and delays that IRECs create when undertaking multi-centre clinical audits

  20. Designed for Learning: A Case Study in Rethinking Teaching and Learning for a Large First Year Class

    Science.gov (United States)

    Goldacre, Lisa; Bolt, Susan; Lambiris, Michael

    2013-01-01

    This paper presents a case study in which the principles of scholarship were applied to designing an approach to learning suitable for large classes. While this case study describes an Australian first year Business Law unit, the findings presented in this paper would be relevant to a wide range of teachers faced with large enrollments in first…

  1. A systematic study of atmospheric pressure chemical vapor deposition growth of large-area monolayer graphene.

    Science.gov (United States)

    Liu, Lixin; Zhou, Hailong; Cheng, Rui; Chen, Yu; Lin, Yung-Chen; Qu, Yongquan; Bai, Jingwei; Ivanov, Ivan A; Liu, Gang; Huang, Yu; Duan, Xiangfeng

    2012-01-28

    Graphene has attracted considerable interest as a potential material for future electronics. Although mechanical peel is known to produce high quality graphene flakes, practical applications require continuous graphene layers over a large area. The catalyst-assisted chemical vapor deposition (CVD) is a promising synthetic method to deliver wafer-sized graphene. Here we present a systematic study on the nucleation and growth of crystallized graphene domains in an atmospheric pressure chemical vapor deposition (APCVD) process. Parametric studies show that the mean size of the graphene domains increases with increasing growth temperature and CH 4 partial pressure, while the density of domains decreases with increasing growth temperature and is independent of the CH 4 partial pressure. Our studies show that nucleation of graphene domains on copper substrate is highly dependent on the initial annealing temperature. A two-step synthetic process with higher initial annealing temperature but lower growth temperature is developed to reduce domain density and achieve high quality full-surface coverage of monolayer graphene films. Electrical transport measurements demonstrate that the resulting graphene exhibits a high carrier mobility of up to 3000 cm 2 V -1 s -1 at room temperature.

  2. Piloted simulator study of allowable time delays in large-airplane response

    Science.gov (United States)

    Grantham, William D.; Bert T.?aetingas, Stephen A.dings with ran; Bert T.?aetingas, Stephen A.dings with ran

    1987-01-01

    A piloted simulation was performed to determine the permissible time delay and phase shift in the flight control system of a specific large transport-type airplane. The study was conducted with a six degree of freedom ground-based simulator and a math model similar to an advanced wide-body jet transport. Time delays in discrete and lagged form were incorporated into the longitudinal, lateral, and directional control systems of the airplane. Three experienced pilots flew simulated approaches and landings with random localizer and glide slope offsets during instrument tracking as their principal evaluation task. Results of the present study suggest a level 1 (satisfactory) handling qualities limit for the effective time delay of 0.15 sec in both the pitch and roll axes, as opposed to a 0.10-sec limit of the present specification (MIL-F-8785C) for both axes. Also, the present results suggest a level 2 (acceptable but unsatisfactory) handling qualities limit for an effective time delay of 0.82 sec and 0.57 sec for the pitch and roll axes, respectively, as opposed to 0.20 sec of the present specifications for both axes. In the area of phase shift between cockpit input and control surface deflection,the results of this study, flown in turbulent air, suggest less severe phase shift limitations for the approach and landing task-approximately 50 deg. in pitch and 40 deg. in roll - as opposed to 15 deg. of the present specifications for both axes.

  3. Personality as a risk factor in large bowel cancer: data from the Melbourne Colorectal Cancer Study.

    Science.gov (United States)

    Kune, G A; Kune, S; Watson, L F; Bahnson, C B

    1991-02-01

    In a case control study which formed one arm of a large, population-based investigation of colorectal cancer incidence, aetiology and survival. 'The Melbourne Colorectal Cancer Study', among others, 22 psychosocially orientated questions were asked by personal interview of 637 histologically confirmed new cases of colorectal cancer and 714 age/sex frequency matched community controls, from Melbourne (population 2.81 million). Self-reported childhood or adult life 'unhappiness' was statistically significantly more common among the cancer cases, while 'unhappiness with retirement' was similarly distributed among cases and controls. Questions which were formulated to test a particular personality profile as a cancer risk, and which included the elements of denial and repression of anger and of other negative emotions, a commitment to prevailing social norms resulting in the external appearance of a 'nice' or 'good' person, a suppression of reactions which may offend others and the avoidance of conflict, showed a statistically significant discrimination between cases and controls. The risk of colorectal cancer with respect to this model was independent of the previously found risk factors of diet, beer intake, and family history of colorectal cancer, and was also independent of other potential confounding factors of socioeconomic level, marital status, religion and country of birth. Although the results must be interpreted with caution, the data are consistent with the hypothesis that this personality type may play a role in the clinical expression of colorectal cancer and merits further study.

  4. Electromagnetic Design Study for a Large Bore 15T Superconducting Dipole Magnet

    CERN Document Server

    Schwerg, N; Devred, Arnaud; Henke, H

    2005-01-01

    In the framework of research and development (R&D) activities at CERN the Next European Dipole (NED) program is one which is to the development of a high-field dipole magnet using Nb_3Sn superconductors. Part of the NED activities is a design study of different possible dipole configurations which is shared amongst the collaborating institutes. This thesis covers the electromagnetic design study of an 88 mm large bore superconducting 15 T dipole magnet with a coil cross section in cos-theta-layer design. Based on analytically describable geometries the sources of multipole errors are studied and elementary estimations of the magnet are carried out, e.g., the required amount of superconductors or the influence of the iron yoke thickness on the field quality. The magnet cross section for NED is optimized by means of the CERN field computation program ROXIE. The preliminary NED design serves as starting point for the coil cross section optimization with respect to field quality and a radial positioning of th...

  5. A study of the transferability of influenza case detection systems between two large healthcare systems.

    Science.gov (United States)

    Ye, Ye; Wagner, Michael M; Cooper, Gregory F; Ferraro, Jeffrey P; Su, Howard; Gesteland, Per H; Haug, Peter J; Millett, Nicholas E; Aronis, John M; Nowalk, Andrew J; Ruiz, Victor M; López Pineda, Arturo; Shi, Lingyun; Van Bree, Rudy; Ginter, Thomas; Tsui, Fuchiang

    2017-01-01

    This study evaluates the accuracy and transferability of Bayesian case detection systems (BCD) that use clinical notes from emergency department (ED) to detect influenza cases. A BCD uses natural language processing (NLP) to infer the presence or absence of clinical findings from ED notes, which are fed into a Bayesain network classifier (BN) to infer patients' diagnoses. We developed BCDs at the University of Pittsburgh Medical Center (BCDUPMC) and Intermountain Healthcare in Utah (BCDIH). At each site, we manually built a rule-based NLP and trained a Bayesain network classifier from over 40,000 ED encounters between Jan. 2008 and May. 2010 using feature selection, machine learning, and expert debiasing approach. Transferability of a BCD in this study may be impacted by seven factors: development (source) institution, development parser, application (target) institution, application parser, NLP transfer, BN transfer, and classification task. We employed an ANOVA analysis to study their impacts on BCD performance. Both BCDs discriminated well between influenza and non-influenza on local test cases (AUCs > 0.92). When tested for transferability using the other institution's cases, BCDUPMC discriminations declined minimally (AUC decreased from 0.95 to 0.94, pdetection performance in two large healthcare systems in two geographically separated regions, providing evidentiary support for the use of automated case detection from routinely collected electronic clinical notes in national influenza surveillance. The transferability could be improved by training Bayesian network classifier locally and increasing the accuracy of the NLP parser.

  6. Sleep and academic performance in later adolescence: results from a large population-based study.

    Science.gov (United States)

    Hysing, Mari; Harvey, Allison G; Linton, Steven J; Askeland, Kristin G; Sivertsen, Børge

    2016-06-01

    The aim of the current study was to assess the association between sleep duration and sleep patterns and academic performance in 16-19 year-old adolescents using registry-based academic grades. A large population-based study from Norway conducted in 2012, the youth@hordaland-survey, surveyed 7798 adolescents aged 16-19 years (53.5% girls). The survey was linked with objective outcome data on school performance. Self-reported sleep measures provided information on sleep duration, sleep efficiency, sleep deficit and bedtime differences between weekday and weekend. School performance [grade point average (GPA)] was obtained from official administrative registries. Most sleep parameters were associated with increased risk for poor school performance. After adjusting for sociodemographic information, short sleep duration and sleep deficit were the sleep measures with the highest odds of poor GPA (lowest quartile). Weekday bedtime was associated significantly with GPA, with adolescents going to bed between 22:00 and 23:00 hours having the best GPA. Also, delayed sleep schedule during weekends was associated with poor academic performance. The associations were somewhat reduced after additional adjustment for non-attendance at school, but remained significant in the fully adjusted models. In conclusion, the demonstrated relationship between sleep problems and poor academic performance suggests that careful assessment of sleep is warranted when adolescents are underperforming at school. Future studies are needed on the association between impaired sleep in adolescence and later functioning in adulthood. © 2016 European Sleep Research Society.

  7. A statewide consortium's adoption of a unified nursing curriculum: evaluation of the first two years.

    Science.gov (United States)

    Tse, Alice M; Niederhauser, Victoria; Steffen, John J; Magnussen, Lois; Morrisette, Nova; Polokoff, Rachael; Chock, Johnelle

    2014-01-01

    This article provides an evaluation of the first two years of implementation of a statewide nursing consortium (SNC) curriculum on nursing faculty work life, teaching productivity, and quality of education. In response to the call for nursing education reform, the SNC incorporated new approaches to competency-based, student-centered learning and clinical education. Faculty and two cohorts of students were measured at three points over the first two years of the curriculum implementation. The expected positive impact of the SNC was documented at the start of the first year, but not sustained. Students reported having more confidence in their clinical skills at the start of the first year, yet demonstrated significantly less confidence in their ability after two years. Faculty indicated that the SNC allowed greater opportunity for collaboration, but that the experience did not alter their classroom performance or satisfaction beyond the first year.

  8. HPV vaccine hesitancy: findings from a statewide survey of health care providers.

    Science.gov (United States)

    McRee, Annie-Laurie; Gilkey, Melissa B; Dempsey, Amanda F

    2014-01-01

    Health care provider recommendations are critical for human papillomavirus (HPV) vaccine uptake. We sought to describe providers' HPV vaccine recommendation practices and explore their perceptions of parental hesitancy. A statewide sample (n = 575) of Minnesota health care providers (20% pediatricians, 47% family medicine physicians, and 33% nurse practitioners) completed our online survey in April 2013. Only 76% of health care providers reported routinely recommending HPV vaccine for girls ages 11 to 12 years, and far fewer (46%) did so for boys (p parents' concerns (74%), but many lacked time to probe reasons (47%) or believed that they could not change parents' minds (55%). Higher levels of self-efficacy and outcome expectations were associated with routine recommendations (p HPV vaccine. Improving providers' self-efficacy to address hesitancy may be important for improving vaccination rates. Copyright © 2014 National Association of Pediatric Nurse Practitioners. Published by Elsevier Inc. All rights reserved.

  9. Illinois statewide gas utility plan, 1993-2002. Volume 1. Executive summary

    International Nuclear Information System (INIS)

    1992-12-01

    The second Illinois Statewide Natural Gas Utility Plan is a continuation of the Least-Cost Planning effort introduced by the Public Utilities Act of 1986. The purpose of the Plan, like its predecessor, is to provide a framework and a set of policies which will allow and encourage local distribution companies to develop least-cost plans consistent with the goals of the Act: to provide efficient, environmentally sound, reliable, and equitable public utility service at the least possible cost. The Plan assesses natural gas demand and supply under five scenarios for the period 1993-2002. Key issues related to the development of least-cost natural gas plans are identified, and policies for addressing the issues are developed. The rationale and potential for natural gas demand side management (DSM) programs and policies are explored, and recommendations made with respect to utility DSM capability-building and DSM cost-recovery

  10. Towards automated statewide land cover mapping in Wisconsin using satellite remote sensing and GIS techniques

    International Nuclear Information System (INIS)

    Cosentino, B.L.; Lillesand, T.M.

    1991-01-01

    Attention is given to an initial research project being performed by the University of Wisconsin-Madison, Environmental Remote Sensing Center in conjunction with seven local, state, and federal agencies to implement automated statewide land cover mapping using satellite remote sensing and geographical information system (GIS) techniques. The basis, progress, and future research needs for this mapping program are presented. The research efforts are directed toward strategies that integrate satellite remote sensing and GIS techniques in the generation of land cover data for multiple users of land cover information. The project objectives are to investigate methodologies that integrate satellite data with other imagery and spatial data resident in emerging GISs in the state for particular program needs, and to develop techniques that can improve automated land cover mapping efficiency and accuracy. 10 refs

  11. Early studies reported extreme findings with large variability: a meta-epidemiologic study in the field of endocrinology.

    Science.gov (United States)

    Wang, Zhen; Alahdab, Fares; Almasri, Jehad; Haydour, Qusay; Mohammed, Khaled; Abu Dabrh, Abd Moain; Prokop, Larry J; Alfarkh, Wedad; Lakis, Sumaya; Montori, Victor M; Murad, Mohammad Hassan

    2016-04-01

    To evaluate the presence of extreme findings and fluctuation in effect size in endocrinology. We systematically identified all meta-analyses published in 2014 in the field of endocrinology. Within each meta-analysis, the effect size of the primary binary outcome was compared across studies according to their order of publication. We pooled studies using the DerSimonian and Laird random-effects method. Heterogeneity was evaluated using the I(2) and tau(2). Twelve percent of the included 100 meta-analyses reported the largest effect size in the very first published study. The largest effect size occurred in the first 2 earliest studies in 31% of meta-analyses. When the effect size was the largest in the first published study, it was three times larger than the final pooled effect (ratio of rates, 3.26; 95% confidence interval: 1.80, 5.90). The largest heterogeneity measured by I(2) was observed in 18% of the included meta-analyses when combining the first 2 studies or 17% when combing the first 3 studies. In endocrinology, early studies reported extreme findings with large variability. This behavior of the evidence needs to be taken into account when used to formulate clinical policies. Copyright © 2016 Elsevier Inc. All rights reserved.

  12. Measurement of fine particles and smoking activity in a statewide survey of 36 California Indian casinos

    Science.gov (United States)

    Jiang, Ru O-Ting; Cheng, Ka I-Chung; Acevedo-Bolton, Viviana; Klepeis, Neil E; Repace, James L; Ott, Wayne R; Hildemann, Lynn M

    2011-01-01

    Despite California's 1994 statewide smoking ban, exposure to secondhand smoke (SHS) continues in California's Indian casinos. Few data are available on exposure to airborne fine particles (PM2.5) in casinos, especially on a statewide basis. We sought to measure PM2.5 concentrations in Indian casinos widely distributed across California, exploring differences due to casino size, separation of smoking and non-smoking areas, and area smoker density. A selection of 36 out of the 58 Indian casinos throughout California were each visited for 1–3 h on weekend or holiday evenings, using two or more concealed monitors to measure PM2.5 concentrations every 10 s. For each casino, the physical dimensions and the number of patrons and smokers were estimated. As a preliminary assessment of representativeness, we also measured eight casinos in Reno, NV. The average PM2.5 concentration for the smoking slot machine areas (63 μg/m3) was nine times as high as outdoors (7 μg/m3), whereas casino non-smoking restaurants (29 μg/m3) were four times as high. Levels in non-smoking slot machine areas varied: complete physical separation reduced concentrations almost to outdoor levels, but two other separation types had mean levels that were 13 and 29 μg/m3, respectively, higher than outdoors. Elevated PM2.5 concentrations in casinos can be attributed primarily to SHS. Average PM2.5 concentrations during 0.5–1 h visits to smoking areas exceeded 35 μg/m3 for 90% of the casino visits. PMID:20160761

  13. Particle generation methods applied in large-scale experiments on aerosol behaviour and source term studies

    International Nuclear Information System (INIS)

    Swiderska-Kowalczyk, M.; Gomez, F.J.; Martin, M.

    1997-01-01

    In aerosol research aerosols of known size, shape, and density are highly desirable because most aerosols properties depend strongly on particle size. However, such constant and reproducible generation of those aerosol particles whose size and concentration can be easily controlled, can be achieved only in laboratory-scale tests. In large scale experiments, different generation methods for various elements and compounds have been applied. This work presents, in a brief from, a review of applications of these methods used in large scale experiments on aerosol behaviour and source term. Description of generation method and generated aerosol transport conditions is followed by properties of obtained aerosol, aerosol instrumentation used, and the scheme of aerosol generation system-wherever it was available. An information concerning aerosol generation particular purposes and reference number(s) is given at the end of a particular case. These methods reviewed are: evaporation-condensation, using a furnace heating and using a plasma torch; atomization of liquid, using compressed air nebulizers, ultrasonic nebulizers and atomization of liquid suspension; and dispersion of powders. Among the projects included in this worked are: ACE, LACE, GE Experiments, EPRI Experiments, LACE-Spain. UKAEA Experiments, BNWL Experiments, ORNL Experiments, MARVIKEN, SPARTA and DEMONA. The aim chemical compounds studied are: Ba, Cs, CsOH, CsI, Ni, Cr, NaI, TeO 2 , UO 2 Al 2 O 3 , Al 2 SiO 5 , B 2 O 3 , Cd, CdO, Fe 2 O 3 , MnO, SiO 2 , AgO, SnO 2 , Te, U 3 O 8 , BaO, CsCl, CsNO 3 , Urania, RuO 2 , TiO 2 , Al(OH) 3 , BaSO 4 , Eu 2 O 3 and Sn. (Author)

  14. Promotoras as data collectors in a large study of physical activity in parks.

    Science.gov (United States)

    Marsh, Terry; Derose, Kathryn Pitkin; Rios, Muriel; Cohen, Deborah

    2015-05-01

    There is a large literature on promotores' involvement in health promotion and a smaller literature on their roles in data collection, most often among predominantly Latino populations. But the extent to which promotores can be successful as the primary data collectors across racially/ethnically and socioeconomically diverse neighborhoods is less well documented. In a study of physical activity in 50 urban neighborhood parks, we found that a team of Spanish/English bilingual promotoras (female promotores) successfully implemented a direct observation protocol in all participant neighborhoods and achieved high interrater reliability (.80-.98). Overall, they were also effective in administering surveys to park users and residents across the racially/ethnically diverse neighborhoods. The promotoras brought to the project important language skills and cultural sensitivity, surveying experience, and familiarity with human subjects and confidentiality issues. Their extensive field experience gained over the course of a long-term collaborative effort helped improve survey and observation protocols. The promotoras reported gaining professional skills, which can strengthen their contributions to other projects. The promotoras were accustomed to being a source of information, and collecting rather than providing information was challenging for some and had to be addressed in order to avoid contamination across study groups. © 2015 Society for Public Health Education.

  15. [Study on plasma temperature of a large area surface discharge by optical emission spectrum].

    Science.gov (United States)

    Dong, Li-Fang; Tong, Guo-Liang; Zhang, Yu; Zhou, Bin

    2014-04-01

    A large area surface discharge was realized in air/argon gas mixture by designing a discharge device with water electrodes. By using optical emission spectrum, the variations of the molecular vibrational temperature, the mean energy of electron, and the electronic excitation temperature as a function of the gas pressure were studied. The nitrogen molecular vibrational temperature was calculated according to the emission line of the second positive band system of the nitrogen molecule (C3 pi(u) --> B 3 pi(g)). The electronic excitation temperature was obtained by using the intensity ratio of Ar I 763.51 nm (2P(6) --> 1S(5)) to Ar I 772.42 nm (2P(2) --> 1S(3)). The changes in the mean energy of electron were studied by the relative intensity ratio of the nitrogen molecular ion 391.4 nm to nitrogen 337.1 nm. It was found that the intensity of emission spectral line increases with the increase in the gas pressure, meanwhile, the outline and the ratios of different spectral lines intensity also change. The molecular vibrational temperature, the mean energy of electron, and the electronic excitation temperature decrease as the gas pressure increases from 0.75 x 10(5) Pa to 1 x 10(5) Pa.

  16. A Phenotype Classification of Internet Use Disorder in a Large-Scale High-School Study

    Directory of Open Access Journals (Sweden)

    Katajun Lindenberg

    2018-04-01

    Full Text Available Internet Use Disorder (IUD affects numerous adolescents worldwide, and (Internet Gaming Disorder, a specific subtype of IUD, has recently been included in DSM-5 and ICD-11. Epidemiological studies have identified prevalence rates up to 5.7% among adolescents in Germany. However, little is known about the risk development during adolescence and its association to education. The aim of this study was to: (a identify a clinically relevant latent profile in a large-scale high-school sample; (b estimate prevalence rates of IUD for distinct age groups and (c investigate associations to gender and education. N = 5387 adolescents out of 41 schools in Germany aged 11–21 were assessed using the Compulsive Internet Use Scale (CIUS. Latent profile analyses showed five profile groups with differences in CIUS response pattern, age and school type. IUD was found in 6.1% and high-risk Internet use in 13.9% of the total sample. Two peaks were found in prevalence rates indicating the highest risk of IUD in age groups 15–16 and 19–21. Prevalence did not differ significantly between boys and girls. High-level education schools showed the lowest (4.9% and vocational secondary schools the highest prevalence rate (7.8%. The differences between school types could not be explained by academic level.

  17. The contribution of environmental isotopes to studies of large aquifers in Morocco

    International Nuclear Information System (INIS)

    Kabbaj, A.; Zeryouhi, I.; Carlier, Ph.

    1979-01-01

    The geochemistry of environmental isotopes has been used for the study of various aquifers in Morocco, some of which are large, such as the Charf el Akab in the Tangiers area, the Oum er Rbia basin and the Turonian aquifer of the Tadla, the free groundwater of the Quaternary lacustrine limestones of the Sais Plain and the Lias limestone aquifer. These isotope studies take hydrogeochemical data into account and have made it possible to determine the conditions of recharge of the aquifers, to distinguish waters of different origin from the Atlas Mountains or from the Phosphate Plateau in the Tadla Basin and the Sais plain, to estimate the recharge of one aquifer by another - for example groundwater of the Lias limestones passing via the folds of the Sais Plain into the lacustrine limestone aquifer - and to test the homogeneity or heterogeneity of these aquifers and their tightness (e.g. the Turonian aquifer of the Tadla and the special case of the Charf el Akab in relation to the marine environment). Altogether, these results made it possible to test the value of the techniques used and to specify the general conditions in which they can profitably be used. (author)

  18. Breast implants and anaplastic large-cell lymphoma: a danish population-based cohort study.

    Science.gov (United States)

    Vase, Maja Ølholm; Friis, Søren; Bautz, Andrea; Bendix, Knud; Sørensen, Henrik Toft; d'Amore, Francesco

    2013-11-01

    A potential link between breast implants and anaplastic large-cell lymphoma (ALCL) has been suggested. We examined lymphoma occurrence in a nationwide cohort of 19,885 Danish women who underwent breast implant surgery during 1973-2010. Standardized incidence ratios (SIR), with 95% confidence intervals (CI), for ALCL and lymphoma overall associated with breast implantation were calculated. During 179,246 person-years of follow-up, we observed 31 cases of lymphoma among cohort members. No cases of ALCL were identified. SIRs for ALCL and lymphoma overall were zero (95% CI, 0-10.3) and 1.20 (95% CI, 0.82-1.70), respectively. In our nationwide cohort study, we did not find an increased risk of lymphoma in general, or ALCL in particular, among Danish women who underwent breast implantation. However, our evaluation of ALCL risk was limited by the rarity of the disease. Our results do not support an association between breast implants and ALCL and are consistent with other studies on cancer risk and breast implants. ©2013 AACR.

  19. Study of the pressing operation of large-sized tiles using X-ray absorption

    International Nuclear Information System (INIS)

    Amoros, J. L.; Mallol, G.; Llorens, D.; Boix, J.; Arnau, J. M.; Feliu, C.; Cerisuelo, J. A.; Gargallo, J. J.

    2010-01-01

    An apparatus for X-Ray non destructive inspection of bulk density distribution in large ceramic tiles has been designed, built and patented. This technique has many advantages compared with other methods: it allows tile bulk density distribution to be mapped and is neither destructive nor toxic, provided the X-ray tube and detector area are shielded to prevent leakage. In the present study, this technique, whose technical feasibility and accuracy had been verified in previous studies, has been used to scan ceramic tiles formed under different industrial conditions, modifying press working parameters. The use of high-precision laser telemeters allows tile thicknesses to be mapped, facilitating the interpretation of manufacturing defects produced in pressing, which cannot be interpreted by just measuring bulk density. The bulk density distributions obtained in the same unfired and fired tiles are also compared, a possibility afforded only by this measurement method, since it is non-destructive. The comparison of both unfired and fired tile bulk density distributions allows the influence of the pressing and firing stages on tile end porosity to be individually identified. (Author) 12 refs.

  20. Efficient stochastic approaches for sensitivity studies of an Eulerian large-scale air pollution model

    Science.gov (United States)

    Dimov, I.; Georgieva, R.; Todorov, V.; Ostromsky, Tz.

    2017-10-01

    Reliability of large-scale mathematical models is an important issue when such models are used to support decision makers. Sensitivity analysis of model outputs to variation or natural uncertainties of model inputs is crucial for improving the reliability of mathematical models. A comprehensive experimental study of Monte Carlo algorithms based on Sobol sequences for multidimensional numerical integration has been done. A comparison with Latin hypercube sampling and a particular quasi-Monte Carlo lattice rule based on generalized Fibonacci numbers has been presented. The algorithms have been successfully applied to compute global Sobol sensitivity measures corresponding to the influence of several input parameters (six chemical reactions rates and four different groups of pollutants) on the concentrations of important air pollutants. The concentration values have been generated by the Unified Danish Eulerian Model. The sensitivity study has been done for the areas of several European cities with different geographical locations. The numerical tests show that the stochastic algorithms under consideration are efficient for multidimensional integration and especially for computing small by value sensitivity indices. It is a crucial element since even small indices may be important to be estimated in order to achieve a more accurate distribution of inputs influence and a more reliable interpretation of the mathematical model results.

  1. Preliminary Study of Position-Sensitive Large-Area Radiation Portal Monitor

    Energy Technology Data Exchange (ETDEWEB)

    Lim, Chang Hwy; Kim, Hyunok; Moon, Myung Kook [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Kim, Jongyul [Korea Advanced Institute of Science and Technology, Daejeon (Korea, Republic of); Park, Jong Won; Lim, Yong Kon [Korea Institute of Ocean Science and Technology, Daejeon (Korea, Republic of)

    2013-10-15

    An RPM, which is a passive inspection method, is a system for monitoring the movement of radioactive materials at an airport, seaport, border, etc. To detect a γ-ray, an RPM using the plastic scintillator is generally used. The method of γ-ray detection using an RPM with a plastic scintillator is to measure lights generated by an incident γ-ray in the scintillator. Generally, a large-area RPM uses one or two photomultiplier tubes (PMT) for light collection. However, in this study, we developed a 4-ch RPM that can measure the radiation signal using 4 PMTs. The reason for using 4 PMTs is to calculate the position of the radiation source. In addition, we developed an electric device for acquisition of a 4-ch output signal at the same time. To estimate the performance of the developed RPM, we performed an RPM test using a {sup 60}Co γ-ray check source. In this study, we performed the development of a 4-ch RPM. The major function of the typical RPM is to measure the radiation. However, we developed a position-sensitive 4-ch RPM, which can be used to measure the location of the radiation source, as well as the radiation measurement, at the same time. In the future, we plan to develop an algorithm for a position detection of the radiation. In addition, an algorithm will be applied to an RPM.

  2. Optical methods to study the gas exchange processes in large diesel engines

    Energy Technology Data Exchange (ETDEWEB)

    Gros, S.; Hattar, C. [Wartsila Diesel International Oy, Vaasa (Finland); Hernberg, R.; Vattulainen, J. [Tampere Univ. of Technology, Tampere (Finland). Plasma Technology Lab.

    1996-12-01

    To be able to study the gas exchange processes in realistic conditions for a single cylinder of a large production-line-type diesel engine, a fast optical absorption spectroscopic method was developed. With this method line-of-sight UV-absorption of SO{sub 2} contained in the exhaust gas was measured as a function of time in the exhaust port area in a continuously fired medium speed diesel engine type Waertsilae 6L20. SO{sub 2} formed during the combustion from the fuel contained sulphur was used as a tracer to study the gas exchange as a function of time in the exhaust channel. In this case of a 4-stroke diesel engine by assuming a known concentration of SO{sub 2} in the exhaust gas after exhaust valve opening and before inlet and exhaust valve overlap period, the measured optical absorption was used to determine the gas density and further the instantaneous exhaust gas temperature during the exhaust cycle. (author)

  3. Summary of the Large Civil Tiltrotor (LCTR2) Engine Gearbox Study

    Science.gov (United States)

    Snyder, Christopher A.; Robuck, Mark; Wilkerson, Joseph; Nordstrom, Carl

    2010-01-01

    In support of the Fundamental Aeronautics Program, Subsonic Rotary Wing Project, NASA is continuing to study the Large Civil Tiltrotor (LCTR) concept to help define/refine vehicle, system and subsystem attributes. These attributes can then be used to define performance requirements and identify new or advanced technologies to achieve an operational vehicle class. As part of this goal, NASA contracted with The Boeing Company and its subcontractor Rolls-Royce to perform an investigation of different combinations of engine and gearbox variability to achieve a maximum of 50 percent rotor tip speed reduction from hover to cruise conditions. Previous NASA studies identified the 50 percent rotor speed reduction minimized vehicle gross weight and fuel burn. The LCTR2 (LCTR-iteration 2) was the contracted study baseline for initial sizing. Rotor tip speed ratios (cruise to hover) of 100, 77, and 54 percent were analyzed for each combination of engine and gearbox speed reduction to achieve the chosen rotor tip speed ratio. Three different engine and gearbox technology levels were assumed; commercial off-the-shelf (COTS), entry-in-service (EIS) in 2025 and EIS in 2035. These technology levels were applied to determine each particular effect on vehicle gross weight and fuel burn, while other vehicle technologies were assumed constant. This report summarizes the work performed that is being put together into a comprehensive NASA contractor report. Some background on the LCTR concept and baseline vehicle will be given and then a discussion concerning the technical approach utilized. Major study assumptions and results will be presented and discussed. Finally conclusions will be drawn as well as suggestions provided for future efforts.

  4. A large-scale study of the random variability of a coding sequence: a study on the CFTR gene.

    Science.gov (United States)

    Modiano, Guido; Bombieri, Cristina; Ciminelli, Bianca Maria; Belpinati, Francesca; Giorgi, Silvia; Georges, Marie des; Scotet, Virginie; Pompei, Fiorenza; Ciccacci, Cinzia; Guittard, Caroline; Audrézet, Marie Pierre; Begnini, Angela; Toepfer, Michael; Macek, Milan; Ferec, Claude; Claustres, Mireille; Pignatti, Pier Franco

    2005-02-01

    Coding single nucleotide substitutions (cSNSs) have been studied on hundreds of genes using small samples (n(g) approximately 100-150 genes). In the present investigation, a large random European population sample (average n(g) approximately 1500) was studied for a single gene, the CFTR (Cystic Fibrosis Transmembrane conductance Regulator). The nonsynonymous (NS) substitutions exhibited, in accordance with previous reports, a mean probability of being polymorphic (q > 0.005), much lower than that of the synonymous (S) substitutions, but they showed a similar rate of subpolymorphic (q < 0.005) variability. This indicates that, in autosomal genes that may have harmful recessive alleles (nonduplicated genes with important functions), genetic drift overwhelms selection in the subpolymorphic range of variability, making disadvantageous alleles behave as neutral. These results imply that the majority of the subpolymorphic nonsynonymous alleles of these genes are selectively negative or even pathogenic.

  5. Effects of a Statewide Protocol for the Management of Peritoneal Dialysis-Related Peritonitis on Microbial Profiles and Antimicrobial Susceptibilities: A Retrospective Five-Year Review.

    Science.gov (United States)

    McGuire, Amanda L; Carson, Christine F; Inglis, Timothy J J; Chakera, Aron

    2015-12-01

    ♦ Peritonitis is a major complication of peritoneal dialysis (PD) and is associated with significant morbidity and mortality. Early empirical antibiotic therapy is recommended, with the choice of agents guided by local resistance patterns. As routine use of specific antimicrobial agents can drive resistance, regular assessment of causative organisms and their susceptibility to empirical therapy is essential. ♦ We conducted a retrospective review of all PD peritonitis cases and positive PD fluid cultures obtained over a 5-year period in Western Australia following the introduction of a statewide protocol for the initial management of PD peritonitis with intraperitoneal vancomycin and gentamicin. ♦ The incidence of PD peritonitis decreased from 1 in 16 patient months (0.75/year at risk) to 1 in 29 patient months (0.41/year at risk) over the 5 years. There were 1,319 culture-positive samples and 1,069 unique isolates identified. Gram-positive bacteria accounted for 69.9% of positive cultures, with vancomycin resistance averaging 2% over the study period. Gram-negative bacteria accounted for 25.4% of positive cultures, with gentamicin resistance identified in an average of 8% of organisms. No increase in antimicrobial resistance to vancomycin or gentamicin occurred over the 5 years and there was no change in the proportion of gram-positive (69.9%), gram-negative (25.4%) or fungal (4.4%) organisms causing PD peritonitis. ♦ Over time, the peritonitis rates have dramatically improved although the profile of causative organisms remains similar. Empirical treatment of PD peritonitis with intraperitoneal vancomycin and gentamicin remains efficacious, with high levels of susceptibility and no evidence that the introduction of this statewide empirical PD peritonitis treatment protocol is driving resistance to these agents. Copyright © 2015 International Society for Peritoneal Dialysis.

  6. Dynamic study of adsorbers by a new gravimetric version of the Large Temperature Jump method

    International Nuclear Information System (INIS)

    Sapienza, Alessio; Santamaria, Salvatore; Frazzica, Andrea; Freni, Angelo; Aristov, Yuri I.

    2014-01-01

    Highlights: • We have carried out a dynamic study of adsorbers. • Activity performed by new gravimetric version of the Large Temperature Jump method. • The kinetics measurements have been carried out under real operating conditions. • Results can support the design of adsorbers for adsorption cooling systems. - Abstract: This paper presents a new experimental setup devoted to measure the ad-/desorption kinetics of an Ad-HEX (adsorbent + heat exchanger) under typical boundary conditions of an Adsorption Heat Transformer (AHT) as well as the results of the first test campaign carried out. The experimental apparatus can be considered as a gravimetric version of the known Large Temperature Jump method. In fact, the dynamic evolution of the uptake during the isobaric ad-/desorption stages is directly measured by a weighing system suitable to work in the range of 5–600 g of sample mass (adsorbent + HEX) with the accuracy ±0.1 g and the time response shorter than 0.1 s The experimental campaign was conducted on an Ad-HEX composed of granules of a commercial SAPO-34 adsorbent placed on a flat type aluminum HEX, under operating conditions reproducing two different thermodynamic cycles (T h = 90 °C, T e = 10 °C, T c = 30 and 35 °C), typical for adsorption air conditioning. The influence of the grain size (ranging from 0.350 to 2.5 mm) on the adsorption dynamics both in monolayer and multilayer configurations at variable and constant “heat transfer surface/adsorbent mass” ratios (S/m) was studied. The results showed that, for the Ad-HEX configurations tested, the adsorption dynamics can be properly described by a modified Linear Driving Force approach by the use of a single temperature-invariant characteristic time τ. The invariance of the specific cooling power was revealed when the S/m ratio was kept constant (S/m = 1.23 m 2 /kg). This ratio is found to be a useful parameter for both assessment of the dynamic perfection and optimization of various Ad

  7. Implementing Summative Assessment with a Formative Flavour: A Case Study in a Large Class

    Science.gov (United States)

    Broadbent, Jaclyn; Panadero, Ernesto; Boud, David

    2018-01-01

    Teaching a large class can present real challenges in design, management and standardisation of assessment practices. One of the main dilemmas for university teachers is how to implement effective formative assessment practices with accompanying high-quality feedback consistently over time with large classroom groups. This article reports on how…

  8. Case Study: Commercialization of sweet sorghum juice clarification for large-scale syrup manufacture

    Science.gov (United States)

    The precipitation and burning of insoluble granules of starch from sweet sorghum juice on heating coils prevented the large scale manufacture of syrup at a new industrial plant in Missouri, USA. To remove insoluble starch granules, a series of small and large-scale experiments were conducted at the...

  9. A Large Eddy Simulation Study of Heat Entrainment under Sea Ice in the Canadian Arctic Basin

    Science.gov (United States)

    Ramudu, E.; Yang, D.; Gelderloos, R.; Meneveau, C. V.; Gnanadesikan, A.

    2016-12-01

    Sea ice cover in the Arctic has declined rapidly in recent decades. The much faster than projected retreat suggests that climate models may be missing some key processes, or that these processes are not accurately represented. The entrainment of heat from the mixed layer by small-scale turbulence is one such process. In the Canadian Basin of the Arctic Ocean, relatively warm Pacific Summer Water (PSW) resides at the base of the mixed layer. With an increasing influx of PSW, the upper ocean in the Canadian Basin has been getting warmer and fresher since the early 2000s. While studies show a correlation between sea ice reduction and an increase in PSW temperature, others argue that PSW intrusions in the Canadian Basin cannot affect sea ice thickness because the strongly-stratified halocline prevents heat from the PSW layer from being entrained into the mixed layer and up to the basal ice surface. In this study, we try to resolve this conundrum by simulating the turbulent entrainment of heat from the PSW layer to a moving basal ice surface using large eddy simulation (LES). The LES model is based on a high-fidelity spectral approach on horizontal planes, and includes a Lagrangian dynamic subgrid model that reduces the need for empirical inputs for subgrid-scale viscosities and diffusivities. This LES tool allows us to investigate physical processes in the mixed layer at a very fine scale. We focus our study on summer conditions, when ice is melting, and show for a range of ice-drift velocities, halocline temperatures, and halocline salinity gradients characteristic of the Canadian Basin how much heat can be entrained from the PSW layer to the sea ice. Our results can be used to improve parameterizations of vertical heat flux under sea ice in coarse-grid ocean and climate models.

  10. A study of the transferability of influenza case detection systems between two large healthcare systems.

    Directory of Open Access Journals (Sweden)

    Ye Ye

    Full Text Available This study evaluates the accuracy and transferability of Bayesian case detection systems (BCD that use clinical notes from emergency department (ED to detect influenza cases.A BCD uses natural language processing (NLP to infer the presence or absence of clinical findings from ED notes, which are fed into a Bayesain network classifier (BN to infer patients' diagnoses. We developed BCDs at the University of Pittsburgh Medical Center (BCDUPMC and Intermountain Healthcare in Utah (BCDIH. At each site, we manually built a rule-based NLP and trained a Bayesain network classifier from over 40,000 ED encounters between Jan. 2008 and May. 2010 using feature selection, machine learning, and expert debiasing approach. Transferability of a BCD in this study may be impacted by seven factors: development (source institution, development parser, application (target institution, application parser, NLP transfer, BN transfer, and classification task. We employed an ANOVA analysis to study their impacts on BCD performance.Both BCDs discriminated well between influenza and non-influenza on local test cases (AUCs > 0.92. When tested for transferability using the other institution's cases, BCDUPMC discriminations declined minimally (AUC decreased from 0.95 to 0.94, p<0.01, and BCDIH discriminations declined more (from 0.93 to 0.87, p<0.0001. We attributed the BCDIH decline to the lower recall of the IH parser on UPMC notes. The ANOVA analysis showed five significant factors: development parser, application institution, application parser, BN transfer, and classification task.We demonstrated high influenza case detection performance in two large healthcare systems in two geographically separated regions, providing evidentiary support for the use of automated case detection from routinely collected electronic clinical notes in national influenza surveillance. The transferability could be improved by training Bayesian network classifier locally and increasing the

  11. First detections of nebula with the Fermi-Large Area Telescope and study of their pulsars

    International Nuclear Information System (INIS)

    Grondin, M.H.

    2010-07-01

    The Fermi Gamma-ray Space Telescope was launched on 2008 June 11, carrying the Large Area Telescope (LAT), sensitive to gamma-rays in the 20 MeV - 300 GeV energy range. The Crab Nebula had been detected and studied in the 70 MeV - 30 GeV band using the CGRO-EGRET experiment, but no pulsar wind nebula (PWN) had ever been firmly identified in the high energy gamma-ray domain. PWNe are powered by the constant injection of a relativistic wind of electrons and positrons from their central pulsars. These charged particles are accelerated at the shock front forming the PWN and emit photons which can be observed along the entire electromagnetic spectrum, including the high energy gamma-ray domain. Data provided by the Fermi-LAT during the first two years of the mission have allowed the detection and the identification of three PWNe and their associated pulsars (Crab Nebula, Vela X and MSH 15-52) as well as the PWN HESS J1825-137 discovered by ground-based experiments sensitive to very high energy gamma-rays. Results of temporal, spectral and morphological analyses of the pulsar/PWN systems detected by Fermi- LAT, as well as results of systematic studies performed first around every gamma-ray pulsar detected by the LAT and secondly around every very high energy source identified as a PWN or a PWN candidate are presented in this dissertation. These studies bring new insights and constraints on the physical properties of the sources as well as on emitting processes in pulsar magnetospheres and in PWNe. (author)

  12. Finasteride Reduces Risk of Bladder Cancer in a Large Prospective Screening Study.

    Science.gov (United States)

    Morales, Edwin E; Grill, Sonja; Svatek, Robert S; Kaushik, Dharam; Thompson, Ian M; Ankerst, Donna P; Liss, Michael A

    2016-03-01

    The androgen receptor has been implicated in the development and progression of bladder cancer (BCa), largely based on studies of animal models. We investigated whether finasteride was associated with a reduced incidence of BCa as observed by self-report in the Prostate, Lung, Colorectal, and Ovarian cancer screening trial. Cox proportional hazard regression analysis was performed to determine the association of finasteride use with time to diagnosis of BCa, controlling for age and tobacco use. Of the 72,370 male participants who met inclusion criteria, 6069 (8.4%) had reported the use of finasteride. BCa was diagnosed in 1.07% (65 of 6069) of those who reported finasteride compared with 1.46% (966 of 66,301) of those who reported no use during the trial. In a multiple Cox regression analysis, self-reported use of finasteride was associated with a decreased risk of development of BCa (hazard ratio: 0.634; 95% confidence interval, 0.493-0.816; p=0.0004), controlling for age and smoking. Limitations of this study include that it is observational and not randomized, that many of the confounding variables for BCa, such as alcohol use, were not available for use in the analysis, and that finasteride use was by annual self-report, which is subject to missing values and error. Finasteride is a common medication used to reduce the size of the prostate and to promote hair growth by manipulating testosterone in men. Men are more likely than women to develop bladder cancer (BCa), but our study noted that men using finasteride were less likely to have a BCa diagnosis. Copyright © 2015 European Association of Urology. Published by Elsevier B.V. All rights reserved.

  13. Predictors of switching from mania to depression in a large observational study across Europe (EMBLEM).

    Science.gov (United States)

    Vieta, Eduard; Angst, Jules; Reed, Catherine; Bertsch, Jordan; Haro, Josep Maria

    2009-11-01

    The risk of switching from mania to depression in bipolar disorder has been poorly studied. Large observational studies may be useful in identifying variables that predict switch to depression after mania and provide data on medication use and outcomes in "real world" patients. EMBLEM (European Mania in Bipolar Longitudinal Evaluation of Medication) is a 2-year, prospective, observational study of patients with a manic/mixed episode. Symptom severity measures included Clinical Global Impression-Bipolar Disorder scale (CGI-BP), Young Mania Rating Scale (YMRS) and 5-item Hamilton Depression Rating Scale. Switching was defined using CGI-BP mania and depression such that patients changed from manic and not depressed to depressed but not manic over two consecutive observations within the first 12 weeks of follow-up. Cox proportional hazards models identified baseline variables independently associated with switch to depression. Of 2390 patients who participated in the maintenance phase (i.e. up to 24 months), 120 (5.0%) switched to depression within the first 12 weeks. Factors associated with greater switching to depression include previous depressive episodes, substance abuse, greater CGI-BP overall severity and benzodiazepine use. Factors associated with lower switching rates were greater CGI-BP depression, lower YMRS severity and atypical antipsychotic use. The definition of switching biased against patients with mixed episodes being likely to switch. Strictly defined, switch to depression from mania occurs in a small proportion of bipolar patients. Clinical history, illness severity, co-morbidities and treatment patterns are associated with switching to depression. Atypical antipsychotics may protect against switch to depression.

  14. A 6-month large-scale study into the safety of tamsulosin

    Science.gov (United States)

    Michel, M C; Bressel, H-U; Goepel, M; Rübben, H

    2001-01-01

    Aims Tamsulosin is an α1-adrenoceptor antagonist for the treatment of symptomatic benign prostatic hyperplasia with a tolerability similar to that of placebo in short-term, placebo-controlled studies with limited patient numbers. The present study was designed to test the safety of tamsulosin treatment in a large cohort of men during a prolonged period of time, particularly with regard to comedications. Methods A multicentre, open-label phase IIIb study with 1784 patients receiving 0.4 mg o.d. tamsulosin for 6 months was performed according to good clinical practice guidelines. The analysis was performed on an intention-to-treat basis and powered to detect adverse events (AE) occurring in 0.15% of patients with 95% confidence. Results During a total drug exposure time of 811 patient years, 386 AE were recorded in 253 patients (14.2%; 95% confidence intervals [CI] 12.0–15.2%). Twenty-nine patients suffered 44 serious AE including five fatal events (CI 0.12–0.73%) due to myocardial infarction (n = 3) and to pneumonia and a car accident (one each), but all deaths were judged to be unlikely to be related to study medication. The frequency of AE in patients without any comedication (n = 1095) was 13.0% (CI 11.3–14.9%). In a logistic regression analysis β-adrenoceptor blockers, converting enzyme inhibitors, antidiabetics and diuretics did not significantly affect the odds ratio for having AE. However, concomitant α-adrenoceptor antagonists (a protocol violation) and treatment with verapamil (which also has α-adrenoceptor antagonist activity) significantly enhanced the odds ratio for having AE to 3.87 (CI 1.52–9.85) and 3.17 (CI 1.52–6.58), respectively. Minor increases in the odds ratio, which did not reach statistical significance, were also observed for Ca2+ antagonists other than verapamil and for nitrates. Conclusions We conclude that tamsulosin has a good safety profile relative to AE rates in the placebo arms of previous studies on tamsulosin even in

  15. Prevalence of polycystic ovary syndrome in women in China: a large community-based study.

    Science.gov (United States)

    Li, Rong; Zhang, Qiufang; Yang, Dongzi; Li, Shangwei; Lu, Shulan; Wu, Xiaoke; Wei, Zhaolian; Song, Xueru; Wang, Xiuxia; Fu, Shuxin; Lin, Jinfang; Zhu, Yimin; Jiang, Yong; Feng, Huai L; Qiao, Jie

    2013-09-01

    What is the prevalence of polycystic ovary syndrome (PCOS) in Han Chinese women from different communities? The prevalence of PCOS in Chinese women aged 19-45 years is 5.6%. The prevalence of PCOS is reported to range from 5 to 10% but to the best of our knowledge the Han Chinese population has not been studied. A large-scale epidemiological study was carried out between October 2007 and September 2011 in 15 924 Han Chinese women of reproductive age (19-45 years) from the 10 provinces and municipalities in China. A total of 16 886 women from 152 cities and 112 villages were involved in the study. All study participants received a questionnaire and underwent a physical and transvaginal ultrasound examination. Blood samples were collected from a subsample of women (n = 3565) for analysis of metabolic markers and hormones. Based on the Rotterdam PCOS criteria, we assessed hyperandrogenism (H), chronic anovulation (O) and polycystic ovaries (P). Following diagnosis, women with PCOS were assigned to one of four different phenotypes. Finally, the prevalence and related risks of PCOS among Chinese women were estimated based on all the data sources. A total of 16 886 women were initially involved in the study and 15 924 eligible participants then completed the study; the overall response rate was 94.3% (15 924/16 886). The prevalence of PCOS in the Chinese community population was 5.6% (894/15 924). Blood samples were analyzed from 833 of these women who were assigned to the four PCOS phenotypes as follows: 19% H + O, 37% H + P, 15% O + P and 29% H + O + P. Comparing the 833 women with PCOS to 2732 women without PCOS indicated that PCOS occurs in younger women (P < 0.05) and these women were prone not only to menstrual problems, hyperandrogenism, PCO and infertility but also metabolic syndrome (MS) and insulin resistance (IR). However, there was no significant difference in the rate of hypertension or hyperlipemia between the two groups. Obese patients with PCOS had a

  16. Multiple lifestyle behaviours and mortality, findings from a large population-based Norwegian cohort study - The HUNT Study

    Directory of Open Access Journals (Sweden)

    Steinar Krokstad

    2017-01-01

    Full Text Available Abstract Background Lifestyle risk behaviours are responsible for a large proportion of disease burden and premature mortality worldwide. Risk behaviours tend to cluster in populations. We developed a new lifestyle risk index by including emerging risk factors (sleep, sitting time, and social participation and examine unique risk combinations and their associations with all-cause and cardio-metabolic mortality. Methods Data are from a large population-based cohort study in a Norway, the Nord-Trøndelag Health Study (HUNT, with an average follow-up time of 14.1 years. Baseline data from 1995–97 were linked to the Norwegian Causes of Death Registry. The analytic sample comprised 36 911 adults aged 20–69 years. Cox regression models were first fitted for seven risk factors (poor diet, excessive alcohol consumption, current smoking, physical inactivity, excessive sitting, too much/too little sleep, and poor social participation separately and then adjusted for socio-demographic covariates. Based on these results, a lifestyle risk index was developed. Finally, we explored common combinations of the risk factors in relation to all-cause and cardio-metabolic mortality outcomes. Results All single risk factors, except for diet, were significantly associated with both mortality outcomes, and were therefore selected to form a lifestyle risk index. Risk of mortality increased as the index score increased. The hazard ratio for all-cause mortality increased from 1.37 (1.15-1.62 to 6.15 (3.56-10.63 as the number of index risk factors increased from one to six respectively. Among the most common risk factor combinations the association with mortality was particularly strong when smoking and/or social participation were included. Conclusions This study adds to previous research on multiple risk behaviours by incorporating emerging risk factors. Findings regarding social participation and prolonged sitting suggest new components of healthy lifestyles and

  17. Optical Coherence Tomography in the UK Biobank Study - Rapid Automated Analysis of Retinal Thickness for Large Population-Based Studies.

    Directory of Open Access Journals (Sweden)

    Pearse A Keane

    Full Text Available To describe an approach to the use of optical coherence tomography (OCT imaging in large, population-based studies, including methods for OCT image acquisition, storage, and the remote, rapid, automated analysis of retinal thickness.In UK Biobank, OCT images were acquired between 2009 and 2010 using a commercially available "spectral domain" OCT device (3D OCT-1000, Topcon. Images were obtained using a raster scan protocol, 6 mm x 6 mm in area, and consisting of 128 B-scans. OCT image sets were stored on UK Biobank servers in a central repository, adjacent to high performance computers. Rapid, automated analysis of retinal thickness was performed using custom image segmentation software developed by the Topcon Advanced Biomedical Imaging Laboratory (TABIL. This software employs dual-scale gradient information to allow for automated segmentation of nine intraretinal boundaries in a rapid fashion.67,321 participants (134,642 eyes in UK Biobank underwent OCT imaging of both eyes as part of the ocular module. 134,611 images were successfully processed with 31 images failing segmentation analysis due to corrupted OCT files or withdrawal of subject consent for UKBB study participation. Average time taken to call up an image from the database and complete segmentation analysis was approximately 120 seconds per data set per login, and analysis of the entire dataset was completed in approximately 28 days.We report an approach to the rapid, automated measurement of retinal thickness from nearly 140,000 OCT image sets from the UK Biobank. In the near future, these measurements will be publically available for utilization by researchers around the world, and thus for correlation with the wealth of other data collected in UK Biobank. The automated analysis approaches we describe may be of utility for future large population-based epidemiological studies, clinical trials, and screening programs that employ OCT imaging.

  18. Femoral bone strength in large theropod dinosaurs: A study by genus

    Science.gov (United States)

    Lee, Scott

    2015-03-01

    The locomotion of bipedal theropod dinosaurs is controlled by the strength of the femur to resist bending torques (caused by the foot striking the ground and the action of muscles on the femur). The section modulus at the narrowest part measures the ability of the femur to resist such torques. We present the results of our study of the femoral section moduli for six genus of large theropods: Tyrannosaurus, Nanotyrannus, Gorgosaurus, and Albertosaurus of the Late Cretaceous, Acrocanthosaurus of the Early Cretaceous, and Allosaurus of the Late Jurassic. These animals had femora of lengths between 65 and 134 cm. The corresponding section moduli varied between 23 and 570 cm3. Some species of Tyrannosaurus, Gorgosaurus, Allosaurus, and Albertosaurus had femora with lengths in the same 75 to 90 cm range. The section moduli of these animals are all in the same range, showing that the animals had the same abilities of locomotion. That is, Allosaurus of the Late Jurassic could locomote just as well as the Late Cretaceous Tyrannosaurus, Gorgosaurus, and Albertosaurus. There is no evidence that these later theropods had evolved to be any faster than similarly-sized theropods living about 80 million years earlier.

  19. Feasibility studies on large sample neutron activation analysis using a low power research reactor

    International Nuclear Information System (INIS)

    Gyampo, O.

    2008-06-01

    Instrumental neutron activation analysis (INAA) using Ghana Research Reactor-1 (GHARR-1) can be directly applied to samples with masses in grams. Samples weights were in the range of 0.5g to 5g. Therefore, the representativity of the sample is improved as well as sensitivity. Irradiation of samples was done using a low power research reactor. The correction for the neutron self-shielding within the sample is determined from measurement of the neutron flux depression just outside the sample. Correction for gamma ray self-attenuation in the sample was performed via linear attenuation coefficients derived from transmission measurements. Quantitative and qualitative analysis of data were done using gamma ray spectrometry (HPGe detector). The results of this study on the possibilities of large sample NAA using a miniature neutron source reactor (MNSR) show clearly that the Ghana Research Reactor-1 (GHARR-1) at the National Nuclear Research Institute (NNRI) can be used for sample analyses up to 5 grams (5g) using the pneumatic transfer systems.

  20. Studies on the nitrogen metabolism of the large intestine of ruminants. 3

    International Nuclear Information System (INIS)

    Kijora, C.; Simon, O.; Bergner, H.; Goersch, R.; Jacobi, U.; Rossow, N.

    1986-01-01

    Two experiments were performed on sheep, receiving on maintenance level a pelleted straw ration high in crude fibre (straw 70.5%; dried sugar beet pulp 12%; cereals 10%; urea 2%; ammonium hydrogen carbonate 3%; minerals 2.5%). The animals were fitted with ileo-cecal re-entrant cannulas. The effects of the introduction of partly hydrolyzed straw meal into the digesta of the large intestine on the digestion processes in that segment were studied. Under these conditions the metabolism of 14 C and 15 N-labelled urea, which was given into the cecum, was estimated. In experiment 1 (E1; 2 animals) unlabelled, precollected digesta were hourly reintroduced together with 14 C and 15 N-labelled urea via the cecal cannula. In experiment 2 (E2; 3 animals) the digesta were supplemented with partly hydrolyzed straw meal (10% of the mean daily dry matter intake with the ration). The supplement of partly hydrolyzed straw meal caused an increase of the 15 N excretion with feces from 13.4% (E1) to 19.8% (E2) of the dose. The 15 N was mainly incorporated in the bacterial fraction (98% E1; 96% E2). As a reason for the increased 15 N incorporation into the bacterial fraction of 106.4 mg 15 N' in E2 vs. 67.3 mg 15 N' in the experiment without straw meal supplement the higher supply of energy as fermentable carbohydrates was assumed. (author)

  1. Revisiting LOFT L2-5 large break test in BEMUSE project context. Sensitivity studies

    International Nuclear Information System (INIS)

    Perez, Marina; Batet, Lluis; Pretel, Carme; Reventos, Francesc

    2005-01-01

    Full text of publication follows: Best estimate codes simulate NPPs behavior in principle without any special conservative assumptions. Due to several factors like code solution methods or user effects, the output parameters calculated have an uncertainty associated. The quantification of the these uncertainties becomes crucial when a safety statement is to be made. It is in this scope that GAMA group from CSNI (OECD/NEA) proposed the international BEMUSE project (Best Estimate - Uncertainty and Sensitivity Evaluation) having as main objective the evaluation of different methodologies for the uncertainty and sensitivity analysis of best-estimate code calculations. A number of methodologies prepared in different countries are used in the development of the project activities. The program work consists of 6 phases and currently the first two have already been concluded. Phase II consists in revisiting the ISP-13, the LOFT loss of coolant experiment L2-5 which simulated a double ended 200% cold leg break of a commercial PWR simultaneous with a loss of site power. In order to connect phase II with phase III, in which the uncertainty analysis will be carried out, quite a large number of sensitivity analysis have been performed by simulating system failures and varying fuel elements parameters among others. The presentation will focus on the results of the sensitivity analysis as well as its importance with regards to the uncertainty studies. The methodology used by UPC team was developed by ENUSA and the work is supported by the Spanish regulatory organization. (authors)

  2. Clinical and linkage study of a large family with simple ectopia lentis linked to FBN1

    Energy Technology Data Exchange (ETDEWEB)

    Edwards, M.J.; Roberts, J.; Partington, M.W. [Newcastle and Northern New South Wales Genetics Service (Australia); Colley, P.W. [John Hunter Hospital, Newcastle (Australia); Hollway, G.E.; Kozman, H.M.; Mulley, J.C. [Adelaide Children`s Hospital, North Adelaide (Australia)

    1994-10-15

    Simple ectopia lentis (EL) was studied in a large family, by clinical examination and analysis of linkage to markers in the region of FBN1, the gene for fibrillin which causes Marfan syndrome on chromosome 15. No patient had clinical or echocardiographic evidence of Marfan syndrome, although there was a trend towards relatively longer measurements of height; lower segment; arm span; middle finger, hand, and foot length in the affected members of the family, compared with unaffected sibs of the same sex. Analysis of linkage to intragenic FBN1 markers was inconclusive because they were relatively uninformative. Construction of a multipoint background map from the CEPH reference families identified microsatellite markers linked closely to FBN1 which could demonstrate linkage of EL in this family to the FBN1 region. LINKMAP analysis detected a multipoint lod score of 5.68 at D15S119, a marker approximately 6 cM distal to FBN1, and a multipoint lod score of 5.04 at FBN1. The EL gene in this family is likely to be allelic to Marfan syndrome, and molecular characterization of the FBN1 mutation should now be possible. 25 refs., 6 figs., 2 tabs.

  3. Large-scale Comparative Study of Hi-C-based Chromatin 3D Structure Modeling Methods

    KAUST Repository

    Wang, Cheng

    2018-05-17

    Chromatin is a complex polymer molecule in eukaryotic cells, primarily consisting of DNA and histones. Many works have shown that the 3D folding of chromatin structure plays an important role in DNA expression. The recently proposed Chro- mosome Conformation Capture technologies, especially the Hi-C assays, provide us an opportunity to study how the 3D structures of the chromatin are organized. Based on the data from Hi-C experiments, many chromatin 3D structure modeling methods have been proposed. However, there is limited ground truth to validate these methods and no robust chromatin structure alignment algorithms to evaluate the performance of these methods. In our work, we first made a thorough literature review of 25 publicly available population Hi-C-based chromatin 3D structure modeling methods. Furthermore, to evaluate and to compare the performance of these methods, we proposed a novel data simulation method, which combined the population Hi-C data and single-cell Hi-C data without ad hoc parameters. Also, we designed a global and a local alignment algorithms to measure the similarity between the templates and the chromatin struc- tures predicted by different modeling methods. Finally, the results from large-scale comparative tests indicated that our alignment algorithms significantly outperform the algorithms in literature.

  4. Large magnetoresistance and Fermi surface study of Sb2Se2Te single crystal

    Science.gov (United States)

    Shrestha, K.; Marinova, V.; Graf, D.; Lorenz, B.; Chu, C. W.

    2017-09-01

    We have studied the magnetotransport properties of a Sb2Se2Te single crystal. Magnetoresistance (MR) is maximum when the magnetic field is perpendicular to the sample surface and reaches a value of 1100% at B = 31 T with no sign of saturation. MR shows Shubnikov de Haas (SdH) oscillations above B = 15 T. The frequency spectrum of SdH oscillations consists of three distinct peaks at α = 32 T, β = 80 T, and γ = 117 T indicating the presence of three Fermi surface pockets. Among these frequencies, β is the prominent peak in the frequency spectrum of SdH oscillations measured at different tilt angles of the sample with respect to the magnetic field. From the angle dependence β and Berry phase calculations, we have confirmed the trivial topology of the β-pocket. The cyclotron masses of charge carriers, obtained by using the Lifshitz-Kosevich formula, are found to be mβ*=0.16mo and m γ*=0.63 mo for the β and γ bands, respectively. The Large MR of Sb2Se2Te is suitable for utilization in electronic instruments such as computer hard discs, high field magnetic sensors, and memory devices.

  5. Large-scale wind power in New Brunswick : a regional scenario study towards 2025

    International Nuclear Information System (INIS)

    2008-08-01

    This paper discussed the large-scale development of wind power in New Brunswick and evaluated Danish experiences with wind development as a template for developing wind resources in the Maritimes region. The study showed that New Brunswick and the Maritimes region have good wind resources, and that the province will gain significant economic benefits from deploying between 5500 and 7500 MW of wind power capacity by 2025. Wind power development will contribute to the security of supply in the region and reduce air pollution. Carbon regulation and renewable portfolio standards will improve the competitiveness of wind power. Electricity generated by wind power plants in the Maritimes can be sold to other provinces in Canada, as well as to the heavily populated New England region of the United States. A high level of cooperation between markets in the Maritimes area and neighbouring New England and Quebec systems will be required in addition to load flow analyses of electricity systems. Denmark's experiences with developing wind power indicate that existing market designs must be restructured to allow for higher levels of competition. A strong system operator is required to integrate wind power into the system. It was concluded that strong political leadership is required to ensure the sustainable development of the region. 5 refs., 4 tabs., 9 figs

  6. Contemporary large-scale international design competitions1 in China. A case study of Baietan, Guangzhou

    Directory of Open Access Journals (Sweden)

    Zheng Liang

    2013-12-01

    Full Text Available The importance of contemporary design competitions has been increasingly recognized in fast-growing China in the course of World Trade Organization (WTO integration and globalization. However, scientific and systematic analysis is rare on how international design competitions are introduced, and how they interact and transplant in the Chinese context. The well-known Chinese-Western culture gap and complicated social and political background make this topic more challenging. Herein, the authors focus on how the international design competitions were “translated” into both international and local perspectives with a compara­tive analysis on development of international design competitions between the Chinese and the Finnish model. To fully exemplify the design-completion procedure and the different roles of Chinese stakeholders and their perspectives on design competitions, the authors study the Baietan case, which was chosen due to its specific relationship with the city’s strategic plan, its representativeness in using international design competitions in connection to large-scale urban projects in China and its public access to the relevant documentation. The preliminary findings suggest that Chinese-style design competitions, acting as ‘designed trading zones’, with less-defined competition rules compared to the Finnish model, may foster the settings of local transformation in adopting international urban planning and design knowledge. However, an integrated approach is required to address subsequent implementation.

  7. Numerical study of whisker field lines in the periphery of the Large Helical Device

    International Nuclear Information System (INIS)

    Akao, Hideki

    1990-01-01

    The behavior of periphery magnetic field lines in the standard Large-Helical Device (l=2 heliotron/torsatron type) configuration is studied numerically. Three different types of behavior are found, corresponding to three different regions: the stochastic region near the outermost magnetic surface, the whisker region, and the inter-whisker region outside the stochastic region. The behavior of whisker and inter-whisker field lines is specifically analyzed. It is found that whisker field lines exhibit both regular and irregular types of behavior, whereas inter-whisker field lines exhibit only regular behavior. The connection lengths for the whisker field lines are usually as long as several tens of toroidal pitches, whereas those for the inter-whisker field lines are usually less than ten toroidal pitch lengths. Whisker field lines are characterized by three fundamental processes; stretching, folding, and nesting associated with the motion of a residual X-point of the separatrix. Simple modeling is performed to reproduce these three fundamental processes. (author)

  8. Large-scale introduction of wind power stations in the Swedish grid: a simulation study

    Energy Technology Data Exchange (ETDEWEB)

    Larsson, L

    1978-08-01

    This report describes a simulation study on the factors to be considered if wind power were to be introduced to the south Swedish power grid on a large scale. The simulations are based upon a heuristic power generation planning model, developed for the purpose. The heuristic technique reflects the actual running strategies of a big power company with suitable accuracy. All simulations refer to certain typical days in 1976 to which all wind data and system characteristics are related. The installed amount of wind power will not be subject to optimization. All differences between planned and real wind power generation is equalized by regulation of the hydro power. The simulations made differ according to how the installed amount of wind power is handled in the power generation planning. The simulations indicate that the power system examined could well bear an introduction of wind power up to a level of 20% of the total power installed. This result is of course valid only for the days examined and does not necessarily apply to the present day structure of the system.

  9. Study of electronic field emission from large surfaces under static operating conditions and hyper-frequency

    International Nuclear Information System (INIS)

    Luong, M.

    1997-09-01

    The enhanced electronic field emission from large area metallic surfaces lowers performances of industrial devices that have to sustain high electric field under vacuum. Despite of numerous investigations in the past, the mechanisms of such an emission have never been well clarified. Recently, research in our laboratory has pointed out the importance played by conducting sites (particles and protrusions). A refined geometrical model, called superposed protrusions model has been proposed to explain the enhanced emission by local field enhancement. As a logical continuation, the present work aims at testing this model and, in the same time, investigating the means to suppress the emission where it is undesirable. Thus, we have showed: the cause of current fluctuations in a continuous field regime (DC), the identity of emission characteristics (β, A e ) in both radiofrequency (RF) and DC regimes, the effectiveness of a thermal treatment by extern high density electronic bombardment, the effectiveness of a mechanical treatment by high pressure rinsing with ultra pure water, the mechanisms and limits of an in situ RF processing. Furthermore, the electronic emission from insulating particles has also been studied concurrently with a spectral analysis of the associated luminous emission. Finally, the refined geometrical model for conducting sites is reinforced while another model is proposed for some insulating sites. Several emission suppressing treatments has been explored and validated. At last, the characteristic of a RF pulsed field emitted electron beam has been checked for the first time as a possible application of such a field emission. (author)

  10. Screening and large-scale expression of membrane proteins in mammalian cells for structural studies.

    Science.gov (United States)

    Goehring, April; Lee, Chia-Hsueh; Wang, Kevin H; Michel, Jennifer Carlisle; Claxton, Derek P; Baconguis, Isabelle; Althoff, Thorsten; Fischer, Suzanne; Garcia, K Christopher; Gouaux, Eric

    2014-11-01

    Structural, biochemical and biophysical studies of eukaryotic membrane proteins are often hampered by difficulties in overexpression of the candidate molecule. Baculovirus transduction of mammalian cells (BacMam), although a powerful method to heterologously express membrane proteins, can be cumbersome for screening and expression of multiple constructs. We therefore developed plasmid Eric Gouaux (pEG) BacMam, a vector optimized for use in screening assays, as well as for efficient production of baculovirus and robust expression of the target protein. In this protocol, we show how to use small-scale transient transfection and fluorescence-detection size-exclusion chromatography (FSEC) experiments using a GFP-His8-tagged candidate protein to screen for monodispersity and expression level. Once promising candidates are identified, we describe how to generate baculovirus, transduce HEK293S GnTI(-) (N-acetylglucosaminyltransferase I-negative) cells in suspension culture and overexpress the candidate protein. We have used these methods to prepare pure samples of chicken acid-sensing ion channel 1a (cASIC1) and Caenorhabditis elegans glutamate-gated chloride channel (GluCl) for X-ray crystallography, demonstrating how to rapidly and efficiently screen hundreds of constructs and accomplish large-scale expression in 4-6 weeks.

  11. Neural networks supporting audiovisual integration for speech: A large-scale lesion study.

    Science.gov (United States)

    Hickok, Gregory; Rogalsky, Corianne; Matchin, William; Basilakos, Alexandra; Cai, Julia; Pillay, Sara; Ferrill, Michelle; Mickelsen, Soren; Anderson, Steven W; Love, Tracy; Binder, Jeffrey; Fridriksson, Julius

    2018-06-01

    Auditory and visual speech information are often strongly integrated resulting in perceptual enhancements for audiovisual (AV) speech over audio alone and sometimes yielding compelling illusory fusion percepts when AV cues are mismatched, the McGurk-MacDonald effect. Previous research has identified three candidate regions thought to be critical for AV speech integration: the posterior superior temporal sulcus (STS), early auditory cortex, and the posterior inferior frontal gyrus. We assess the causal involvement of these regions (and others) in the first large-scale (N = 100) lesion-based study of AV speech integration. Two primary findings emerged. First, behavioral performance and lesion maps for AV enhancement and illusory fusion measures indicate that classic metrics of AV speech integration are not necessarily measuring the same process. Second, lesions involving superior temporal auditory, lateral occipital visual, and multisensory zones in the STS are the most disruptive to AV speech integration. Further, when AV speech integration fails, the nature of the failure-auditory vs visual capture-can be predicted from the location of the lesions. These findings show that AV speech processing is supported by unimodal auditory and visual cortices as well as multimodal regions such as the STS at their boundary. Motor related frontal regions do not appear to play a role in AV speech integration. Copyright © 2018 Elsevier Ltd. All rights reserved.

  12. VUV photoemission studies of candidate Large Hadron Collider vacuum chamber materials

    CERN Document Server

    Cimino, R; Baglin, V

    1999-01-01

    In the context of future accelerators and, in particular, the beam vacuum of the Large Hadron Collider (LHC), a 27 km circumference proton collider to be built at CERN, VUV synchrotron radiation (SR) has been used to study both qualitatively and quantitatively candidate vacuum chamber materials. Emphasis is given to show that angle and energy resolved photoemission is an extremely powerful tool to address important issues relevant to the LHC, such as the emission of electrons that contributes to the creation of an electron cloud which may cause serious beam instabilities and unmanageable heat loads on the cryogenic system. Here we present not only the measured photoelectron yields from the proposed materials, prepared on an industrial scale, but also the energy and in some cases the angular dependence of the emitted electrons when excited with either a white light (WL) spectrum, simulating that in the arcs of the LHC, or monochromatic light in the photon energy range of interest. The effects on the materials ...

  13. Study of Drell-Yan process in CMS experiment at Large Hadron Collider

    CERN Document Server

    Jindal, Monika

    The proton-proton collisions at the Large Hadron Collider (LHC) is the begining of a new era in the high energy physics. It enables the possibility of the discoveries at high-energy frontier and also allows the study of Standard Model physics with high precision. The new physics discoveries and the precision measurements can be achieved with highly efficient and accurate detectors like Compact Muon Solenoid. In this thesis, we report the measurement of the differential production cross-section of the Drell-Yan process, $q ar{q} ightarrow Z/gamma^{*} ightarrowmu^{+}mu^{-}$ in proton-proton collisions at the center-of-mass energy $sqrt{s}=$ 7 TeV using CMS experiment at the LHC. This measurement is based on the analysis of data which corresponds to an integrated luminosity of $intmath{L}dt$ = 36.0 $pm$ 1.4 pb$^{-1}$. The measurement of the production cross-section of the Drell-Yan process provides a first test of the Standard Model in a new energy domain and may reveal exotic physics processes. The Drell...

  14. Large-scale replication study reveals a limit on probabilistic prediction in language comprehension.

    Science.gov (United States)

    Nieuwland, Mante S; Politzer-Ahles, Stephen; Heyselaar, Evelien; Segaert, Katrien; Darley, Emily; Kazanina, Nina; Von Grebmer Zu Wolfsthurn, Sarah; Bartolozzi, Federica; Kogan, Vita; Ito, Aine; Mézière, Diane; Barr, Dale J; Rousselet, Guillaume A; Ferguson, Heather J; Busch-Moreno, Simon; Fu, Xiao; Tuomainen, Jyrki; Kulakova, Eugenia; Husband, E Matthew; Donaldson, David I; Kohút, Zdenko; Rueschemeyer, Shirley-Ann; Huettig, Falk

    2018-04-03

    Do people routinely pre-activate the meaning and even the phonological form of upcoming words? The most acclaimed evidence for phonological prediction comes from a 2005 Nature Neuroscience publication by DeLong, Urbach and Kutas, who observed a graded modulation of electrical brain potentials (N400) to nouns and preceding articles by the probability that people use a word to continue the sentence fragment ('cloze'). In our direct replication study spanning 9 laboratories ( N =334), pre-registered replication-analyses and exploratory Bayes factor analyses successfully replicated the noun-results but, crucially, not the article-results. Pre-registered single-trial analyses also yielded a statistically significant effect for the nouns but not the articles. Exploratory Bayesian single-trial analyses showed that the article-effect may be non-zero but is likely far smaller than originally reported and too small to observe without very large sample sizes. Our results do not support the view that readers routinely pre-activate the phonological form of predictable words. © 2018, Nieuwland et al.

  15. Study of the nonequilibrium state of superconductors by large quasiparticle injection from an external current source

    International Nuclear Information System (INIS)

    Iguchi, I.

    1977-01-01

    We have studied the nonequilibrium state of superconductors by injecting large numbers of quasiparticles from an external current source into a superconducting film of a tunnel junction with low tunnel resistance (typically 0.1--1 Ω for junction area approx. = 10 -4 cm 2 ). It was observed that there was a critical tunnel current density at which a voltage appeared locally in the part of a superconducting film confined to the junction area. Its values ranged from 10 2 to 10 3 A/cm 2 for bath temperatures well below T/sub c/. Followed by this voltage onset, a transition region corresponding to the nonequilibrium intermediate resistive state was also observed. For further increase of the tunnel current, the local film resistance developed beyond the value of its normal resistance, suggesting that the nonequilibrium state extends far beyond the voltage onset point. A theory based on the modified Rothwarf-Taylor equations and Parker's T* model is presented to compare with the experimental results. The calculated critical current density yielded almost the same order of magnitude as those found experimentally. The detailed behavior, however, deviates from the theoretical predictions although the film makes a second-order transition in the broad range of temperatures. It is also shown using four-terminal analysis that our observations and those by Wong, Yeh, and Langenberg are essentially the same

  16. Experimental study of the flow field behind a large wind turbine

    Energy Technology Data Exchange (ETDEWEB)

    Asimakopoulos, D.N.; Helmis, C.G; Kambezidis, H.; Hoegstroem, U.

    1985-01-01

    The paper describes the recent joint experimental work of Uppsala and University of Athens in Sweden. Major target of this work was the study of the flow field behind a large, 2 MW, WECS at Naesudden in Gotland island. For this purpose the near-by 145m meteorgological mast which was specially equipped with turbulence instruments together with two tethered balloon systems and a specially designed high resolution acoustic sounder in a novel configuration were used. Measurements were taken under different meteorological conditions during summer 1984. Preliminary results will be presented which will include profiles of major meteorological paramenters and their associated statistics from the mast during occasions with the turbulent flow from their turbine passing through, as well as tethered balloon ascends in and out of the wake. Along-side the meterological instrumentation a triple acoustic sounder system in a split 'umbrella' configuration was giving turbulence and wind information at different distances from the WECS and in some occasions covering part of the expected wake and part of the free of turbulence region.

  17. Large-eddy simulation study of oil/gas plumes in stratified fluid with cross current

    Science.gov (United States)

    Yang, Di; Xiao, Shuolin; Chen, Bicheng; Chamecki, Marcelo; Meneveau, Charles

    2017-11-01

    Dynamics of the oil/gas plume from a subsea blowout are strongly affected by the seawater stratification and cross current. The buoyant plume entrains ambient seawater and lifts it up to higher elevations. During the rising process, the continuously increasing density difference between the entrained and ambient seawater caused by the stable stratification eventually results in a detrainment of the entrained seawater and small oil droplets at a height of maximum rise (peel height), forming a downward plume outside the rising inner plume. The presence of a cross current breaks the plume's axisymmetry and causes the outer plume to fall along the downstream side of the inner plume. The detrained seawater and oil eventually fall to a neutral buoyancy level (trap height), and disperse horizontally to form an intrusion layer. In this study, the complex plume dynamics is investigated using large-eddy simulation (LES). Various laboratory and field scale cases are simulated to explore the effect of cross current and stratification on the plume dynamics. Based on the LES data, various turbulence statistics of the plume are systematically quantified, leading to some useful insights for modeling the mean plume dynamics using integral plume models. This research is made possible by a RFP-V Grant from The Gulf of Mexico Research Initiative.

  18. Drivers and barriers of reverse logistics practices: A study of large grocery retailers in South Africa

    Directory of Open Access Journals (Sweden)

    Arno Meyer

    2017-08-01

    Full Text Available Background: Reverse logistics (RL practices have previously been viewed as a cost drain, but have received greater attention from practitioners because of increasing competition and dwindling margins. Purpose: The purpose of this generic qualitative study was to uncover the main internal and external drivers and barriers of RL within major South African grocery retailers. Method: Eleven face-to-face, semi-structured interviews and one telephonic interview were conducted with participants from four large grocery retailers. Findings: Optimising profitability and cost reduction goals are the identified internal drivers, whereas the main external driver was to reduce the organisations’ environmental impact. A lack of information systems – such as enterprise resource planning systems or warehouse management system software – and infrastructure were revealed as the main internal barriers for organisations’ RL practices, whereas supplier non-compliance and transportation inefficiencies were the main external barriers exposed. Managerial implications: In order to optimise the efficiency of the reverse flow, managers are recommended to devote more capital to RL infrastructure, develop policies to manage supplier behaviour, focus on RL as a revenue generating stream as well as implement information systems to manage the entire reverse flow. Conclusion: All participating grocery retailers follow similar RL processes. Growth in RL practices as well as infrastructure to perform those practices is a future priority for all the reviewed grocery retailers. RL is no longer only a key cost driver, but also provides organisations with many additional opportunities.

  19. Statewide ban on recreational fires resulted in a significant decrease in campfire-related summer burn center admissions.

    Science.gov (United States)

    Hoang, David Manh; Reid, Dixie; Lentz, Christopher William

    2013-01-01

    Every summer, there is an increase in the number of burn injuries caused by accidents around campfires. Because of the prevalence of drought, high winds, and uncontrolled wild fires, a statewide ban on recreational fires was instituted in New Mexico from June to July 2011. We hypothesized that this legislation would have a significant impact on burn admissions caused by campfire-related injuries. A retrospective review of summer admissions to a state burn center was conducted to assess the effect of this ban on recreational fire injuries, and these data were compared with that of the previous summer when no ban was in effect. All burn admissions to a state burn center were reviewed from Memorial Day to Labor Day in 2010 and 2011. Data collected included cause, % TBSA, age, days of hospitalization, intensive care unit days, and total surface area grafted. Nonparametric statistical analysis was performed with Fisher exact test for dichotomous data and Mann-Whitney test for continuous data with significance at P fires during the study period (n = 14 [17%] in 2010 and 4 [5%] in 2011; P = .02). This resulted in a decrease in the number of patient-days from 91 in 2010 to 25 in 2011. Half of the camp fire admissions required skin grafts to definitively close the wounds (6/14 in 2010 and 2/4 in 2011). Recreational fire bans targeted at controlling wildfires during conditions favoring rapid spread were associated with a 3- to 4-fold decrease in campfire-related burn admissions. Compared with a summer when no fire ban was in effect, the number of patient-days decreased from 91 to 25.

  20. Disseminating quality improvement: study protocol for a large cluster-randomized trial

    Directory of Open Access Journals (Sweden)

    French Michael T

    2011-04-01

    with outcome data will be included in the analysis, following the intent-to-treat principle. Organizational covariates in the analysis include program size, management score, and state. Discussion The study offers seven recommendations for conducting a large-scale cluster-randomized trial: provide valuable services, have aims that are clear and important, seek powerful allies, understand the recruiting challenge, cultivate commitment, address turnover, and encourage rigor and flexibility. Trial Registration ClinicalTrials. govNCT00934141

  1. Study on the structure and level of electricity prices for Northwest-European large-scale consumers

    International Nuclear Information System (INIS)

    2006-06-01

    The aim of the study on the title subject is to make an overview of the structure and developments of electricity prices for large-scale consumers in Northwest-Europe (Netherlands, Germany, Belgium and France) and of current regulations for large-scale consumers in Europe [nl

  2. Location and characterization of the warfarin binding site of human serum albumin A comparative study of two large fragments

    NARCIS (Netherlands)

    Bos, O.J.M.; Remijn, J.P.M.; Fischer, M.J.E.; Wilting, J.; Janssen, L.H.M.

    1988-01-01

    The warfarin binding behaviour of a large tryptic fragment (residues 198–585 which comprise domains two and three) and of a large peptic fragment (residues 1–387 which comprise domains one and two) of human serum albumin has been studied by circular dichroism and equilibrium dialysis in order to

  3. Study of shape evaluation for mask and silicon using large field of view

    Science.gov (United States)

    Matsuoka, Ryoichi; Mito, Hiroaki; Shinoda, Shinichi; Toyoda, Yasutaka

    2010-09-01

    We have developed a highly integrated method of mask and silicon metrology. The aim of this integration is evaluating the performance of the silicon corresponding to Hotspot on a mask. It can use the mask shape of a large field, besides. The method adopts a metrology management system based on DBM (Design Based Metrology). This is the high accurate contouring created by an edge detection algorithm used in mask CD-SEM and silicon CD-SEM. Currently, as semiconductor manufacture moves towards even smaller feature size, this necessitates more aggressive optical proximity correction (OPC) to drive the super-resolution technology (RET). In other words, there is a trade-off between highly precise RET and mask manufacture, and this has a big impact on the semiconductor market that centers on the mask business. As an optimal solution to these issues, we provide a DFM solution that extracts 2-dimensional data for a more realistic and error-free simulation by reproducing accurately the contour of the actual mask, in addition to the simulation results from the mask data. On the other hand, there is roughness in the silicon form made from a mass-production line. Moreover, there is variation in the silicon form. For this reason, quantification of silicon form is important, in order to estimate the performance of a pattern. In order to quantify, the same form is equalized in two dimensions. And the method of evaluating based on the form is popular. In this study, we conducted experiments for averaging method of the pattern (Measurement Based Contouring) as two-dimensional mask and silicon evaluation technique. That is, observation of the identical position of a mask and a silicon was considered. The result proved its detection accuracy and reliability of variability on two-dimensional pattern (mask and silicon) and is adaptable to following fields of mask quality management. •Discrimination of nuisance defects for fine pattern. •Determination of two-dimensional variability of

  4. Suicide Among Inuit: Results From a Large, Epidemiologically Representative Follow-Back Study in Nunavut

    Science.gov (United States)

    Chachamovich, Eduardo; Kirmayer, Laurence J; Haggarty, John M; Cargo, Margaret; McCormick, Rod; Turecki, Gustavo

    2015-01-01

    Objective: The Inuit population in Canada’s North has suffered from high rates of death by suicide. We report on the first large-scale, controlled, epidemiologically representative study of deaths by suicide in an Indigenous population, which investigates risk factors for suicide among all Inuit across Nunavut who died by suicide during a 4-year period. Methods: We identified all suicides by Inuit (n = 120) that occurred between January 1, 2003, and December 31, 2006, in Nunavut. For each subject, we selected a community-matched control subject. We used proxy-based procedures and conducted structured interviews with informants to obtain life histories, Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Axis I and II diagnoses, and measures of impulsive and (or) aggressive traits. Results: Compared with control subjects, subjects who died by suicide were more likely to have experienced childhood abuse (OR 2.38; 95% CI 1.39 to 4.08), have family histories of major depressive disorder (P = 0.002) and suicide completion (P = 0.02), and have been affected by major depressive disorder (OR 13.00; 95% CI 6.20 to 27.25), alcohol dependence (OR 2.90; 95% CI 1.59 to 5.24), or cannabis dependence (OR 3.96; 95% CI 2.29 to 6.8) in the last 6 months. In addition, subjects who died by suicide were more likely to have been affected with cluster B personality disorders (OR 10.18; 95% CI 3.34 to 30.80) and had higher scores of impulsive and aggressive traits (P suicide among Inuit are similar to those observed in studies with the general population, and indicate a need for improved access to mental health services. The high rate of mental health problems among control subjects suggests the need for population-level mental health promotion. PMID:26175324

  5. Modification of the gasless fetoscopy technique for the treatment of large myelomeningocele: a study in sheep

    Directory of Open Access Journals (Sweden)

    Denise Araujo Lapa Pedreira

    2010-03-01

    Full Text Available Objective: To change the gasless fetoscopy technique in order to reduce the diameter of entry orifices in the myometrium. Methods: Seven pregnant ewes were submitted to fetoscopy for repairing a large skin defect measuring 4.0 x 3.0 cm, created in the fetal lumbar region at the gestational age of 100 days. The defect was repaired through continuous suture of the skin with approximation of borders. Gasless fetoscopy was used for performing the suture with three orifices to allow entry of the trocar into the myometrium. A 5.0-mm optical trocar, and 3.5-mm grasping, dissecting and suturing forceps were used. After surgery, pregnancy was maintained until the animals were euthanized on the 133rd day of gestation, and the fetuses were evaluated. Results: Seven pregnant ewes underwent surgery; the first two cases were characterized as the Pilot Group, in which the endoscopic technique was modified and caliber reduction was possible in two out of three entry orifices in the myometrium. In the five remaining cases (Study Group, the repair was successfully carried out in all the fetuses, and the mean duration of fetoscopy was 98 minutes. There was a case of maternal death attributed to intrauterine infection. Mean intrauterine permanence after surgery was 12 days. Conclusions: The technique was successfully modified, allowing reduction of the uterine orifices necessary to perform the repair of a skin defect in the fetal lumbar region through a new fetoscopy technique. The impact of this modification in repair of myelomeningocele in human fetuses should be studied.

  6. Tracking the distribution of "ecstasy" tablets by Raman composition profiling: a large scale feasibility study.

    Science.gov (United States)

    Bell, Steven E J; Barrett, Lindsay J; Burns, D Thorburn; Dennis, Andrew C; Speers, S James

    2003-11-01

    Here we report the results of the largest study yet carried out on composition profiling of seized "ecstasy" tablets by Raman spectroscopy. Approximately 1500 tablets from different seizures in N. Ireland were analysed and even though practically all the tablets contained MDMA as active constituent, there were very significant differences in their Raman spectra, which were due to variations in both the nature and concentration of the excipients used and/or the degree of hydration of the MDMA. The ratios of the peak heights of the prominent drug bands at 810 cm(-1) and 716 cm(-1) (which vary with hydration state of the drug), and the drug band at 810 cm(-1) against the largest clearly discernible excipient band in the spectrum were measured for all the samples. It was found that there was sufficient variation in composition in the general sample population to make any matches between batches of tablets taken from different seizures significant, rather than the result of random chance. Despite the large number of different batches of tablets examined in this study, only two examples of indistinguishable sets of tablets were found and in only one of these had the two batches of tablets been seized at different times. Finally, the fact that there are many examples of batches of tablets (particularly in different batches taken from single seizures) in which the differences between each set are sufficiently small that they appear to arise only from random variations within a standard manufacturing method implies that, with more extensive data, it may be possible to recognize the "signature" of tablets prepared by major manufacturers.

  7. Course of Tourette Syndrome and Comorbidities in a Large Prospective Clinical Study.

    Science.gov (United States)

    Groth, Camilla; Mol Debes, Nanette; Rask, Charlotte Ulrikka; Lange, Theis; Skov, Liselotte

    2017-04-01

    Tourette syndrome (TS) is a childhood-onset neurodevelopmental disorder characterized by tics and frequent comorbidities. Although tics often improve during adolescence, recent studies suggest that comorbid obsessive-compulsive disorder (OCD) and attention-deficit/hyperactivity disorder (ADHD) tend to persist. This large prospective follow-up study describes the clinical course of tics and comorbidities during adolescence and the prevalence of coexisting psychopathologies. The clinical cohort was recruited at the Danish National Tourette Clinic, and data were collected at baseline (n = 314, age range 5-19 years) and at follow-up 6 years later (n = 227) to establish the persistence and severity of tics and comorbidities. During follow-up, the Development and Well-Being Assessment (DAWBA) was used to diagnose coexisting psychopathologies. Repeated measures of severity scores were modeled using mixed effects models. Tic severity declined yearly (0.8 points, CI: 0.58-1.01, on the Yale Global Tic Severity Scale [YGTSS]) during adolescence; 17.7% of participants above age 16 years had no tics, whereas 59.5% had minimal or mild tics, and 22.8% had moderate or severe tics. Similarly, significant yearly declines in severity of both OCD (0.24, CI: 0.09-0.39, on the Yale-Brown Obsessive Compulsive Scale for Adults [Y-BOCS] and Yale-Brown Obsessive Compulsive Scale for Children [CY-BOCS]) and ADHD (0.42, CI: 0.32-0.52, DSM-IV) were recorded. At follow-up, 63.0% of participants had comorbidities or coexistent psychopathologies, whereas 37.0% had pure TS. Severity of tics, OCD, and ADHD were significantly associated with age and declined during adolescence. However, considerable comorbidities and coexisting psychopathologies persist throughout adolescence and require monitoring by clinicians. Copyright © 2017 American Academy of Child and Adolescent Psychiatry. Published by Elsevier Inc. All rights reserved.

  8. Experimental study of the impact of large-scale wind farms on land–atmosphere exchanges

    International Nuclear Information System (INIS)

    Zhang Wei; Markfort, Corey D; Porté-Agel, Fernando

    2013-01-01

    Large-scale wind farms, covering a significant portion of the land and ocean surface, may affect the transport of momentum, heat, mass and moisture between the atmosphere and the land locally and globally. To understand the wind-farm–atmosphere interaction, we conducted wind-tunnel experiments to study the surface scalar (heat) flux using model wind farms, consisting of more than ten rows of wind turbines—having typical streamwise and spanwise spacings of five and four rotor diameters—in a neutral boundary layer with a heated surface. The spatial distribution of the surface heat flux was mapped with an array of surface heat flux sensors within the quasi-developed regime of the wind-farm flow. Although the overall surface heat flux change produced by the wind farms was found to be small, with a net reduction of 4% for a staggered wind farm and nearly zero change for an aligned wind farm, the highly heterogeneous spatial distribution of the surface heat flux, dependent on the wind-farm layout, was significant. The difference between the minimum and maximum surface heat fluxes could be up to 12% and 7% in aligned and staggered wind farms, respectively. This finding is important for planning intensive agriculture practice and optimizing farm land use strategy regarding wind energy project development. The well-controlled wind-tunnel experiments presented in this study also provide a first comprehensive dataset on turbulent flow and scalar transport in wind farms, which can be further used to develop and validate new parameterizations of surface scalar fluxes in numerical models. (letter)

  9. Suicide Among Inuit: Results From a Large, Epidemiologically Representative Follow-Back Study in Nunavut.

    Science.gov (United States)

    Chachamovich, Eduardo; Kirmayer, Laurence J; Haggarty, John M; Cargo, Margaret; Mccormick, Rod; Turecki, Gustavo

    2015-06-01

    The Inuit population in Canada's North has suffered from high rates of death by suicide. We report on the first large-scale, controlled, epidemiologically representative study of deaths by suicide in an Indigenous population, which investigates risk factors for suicide among all Inuit across Nunavut who died by suicide during a 4-year period. We identified all suicides by Inuit (n = 120) that occurred between January 1, 2003, and December 31, 2006, in Nunavut. For each subject, we selected a community-matched control subject. We used proxy-based procedures and conducted structured interviews with informants to obtain life histories, Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Axis I and II diagnoses, and measures of impulsive and (or) aggressive traits. Compared with control subjects, subjects who died by suicide were more likely to have experienced childhood abuse (OR 2.38; 95% CI 1.39 to 4.08), have family histories of major depressive disorder (P = 0.002) and suicide completion (P = 0.02), and have been affected by major depressive disorder (OR 13.00; 95% CI 6.20 to 27.25), alcohol dependence (OR 2.90; 95% CI 1.59 to 5.24), or cannabis dependence (OR 3.96; 95% CI 2.29 to 6.8) in the last 6 months. In addition, subjects who died by suicide were more likely to have been affected with cluster B personality disorders (OR 10.18; 95% CI 3.34 to 30.80) and had higher scores of impulsive and aggressive traits (P Inuit are similar to those observed in studies with the general population, and indicate a need for improved access to mental health services. The high rate of mental health problems among control subjects suggests the need for population-level mental health promotion.

  10. Phenomenology of OCD: lessons from a large multicenter study and implications for ICD-11.

    Science.gov (United States)

    Shavitt, Roseli G; de Mathis, Maria Alice; Oki, Fábio; Ferrao, Ygor A; Fontenelle, Leonardo F; Torres, Albina R; Diniz, Juliana B; Costa, Daniel L C; do Rosário, Maria Conceição; Hoexter, Marcelo Q; Miguel, Euripedes C; Simpson, H Blair

    2014-10-01

    This study aimed to investigate the phenomenology of obsessive-compulsive disorder (OCD), addressing specific questions about the nature of obsessions and compulsions, and to contribute to the World Health Organization's (WHO) revision of OCD diagnostic guidelines. Data from 1001 patients from the Brazilian Research Consortium on Obsessive-Compulsive Spectrum Disorders were used. Patients were evaluated by trained clinicians using validated instruments, including the Dimensional Yale-Brown Obsessive-Compulsive Scale, the University of Sao Paulo Sensory Phenomena Scale, and the Brown Assessment of Beliefs Scale. The aims were to compare the types of sensory phenomena (SP, subjective experiences that precede or accompany compulsions) in OCD patients with and without tic disorders and to determine the frequency of mental compulsions, the co-occurrence of obsessions and compulsions, and the range of insight. SP were common in the whole sample, but patients with tic disorders were more likely to have physical sensations and urges only. Mental compulsions occurred in the majority of OCD patients. It was extremely rare for OCD patients to have obsessions without compulsions. A wide range of insight into OCD beliefs was observed, with a small subset presenting no insight. The data generated from this large sample will help practicing clinicians appreciate the full range of OCD symptoms and confirm prior studies in smaller samples the degree to which insight varies. These findings also support specific revisions to the WHO's diagnostic guidelines for OCD, such as describing sensory phenomena, mental compulsions and level of insight, so that the world-wide recognition of this disabling disorder is increased. Copyright © 2014 Elsevier Ltd. All rights reserved.

  11. The HAPPY study (Holistic Approach to Pregnancy and the first Postpartum Year): design of a large prospective cohort study.

    Science.gov (United States)

    Truijens, Sophie E M; Meems, Margreet; Kuppens, Simone M I; Broeren, Maarten A C; Nabbe, Karin C A M; Wijnen, Hennie A; Oei, S Guid; van Son, Maarten J M; Pop, Victor J M

    2014-09-08

    The HAPPY study is a large prospective longitudinal cohort study in which pregnant women (N ≈ 2,500) are followed during the entire pregnancy and the whole first year postpartum. The study collects a substantial amount of psychological and physiological data investigating all kinds of determinants that might interfere with general well-being during pregnancy and postpartum, with special attention to the effect of maternal mood, pregnancy-related somatic symptoms (including nausea and vomiting (NVP) and carpal tunnel syndrome (CTS) symptoms), thyroid function, and human chorionic gonadotropin (HCG) on pregnancy outcome of mother and foetus. During pregnancy, participants receive questionnaires at 12, 22 and 32 weeks of gestation. Apart from a previous obstetric history, demographic features, distress symptoms, and pregnancy-related somatic symptoms are assessed. Furthermore, obstetrical data of the obstetric record form and ultrasound data are collected during pregnancy. At 12 and 30 weeks, thyroid function is assessed by blood analysis of thyroid stimulating hormone (TSH), free thyroxine (FT4) and thyroid peroxidase antibodies (TPO-Ab), as well as HCG. Also, depression is assessed with special focus on the two key symptoms: depressed mood and anhedonia. After childbirth, cord blood, neonatal heel screening results and all obstetrical data with regard to start of labour, mode of delivery and complications are collected. Moreover, mothers receive questionnaires at one week, six weeks, four, eight, and twelve months postpartum, to investigate recovery after pregnancy and delivery, including postpartum mood changes, emotional distress, feeding and development of the newborn. The key strength of this large prospective cohort study is the holistic (multifactorial) approach on perinatal well-being combined with a longitudinal design with measurements during all trimesters of pregnancy and the whole first year postpartum, taking into account two physiological possible

  12. Longitudinal heterogeneity of flow and heat fluxes in a large lowland river: A study of the San Joaquin River, CA, USA during a large-scale flow experiment

    Science.gov (United States)

    Bray, E. N.; Dunne, T.; Dozier, J.

    2011-12-01

    Systematic downstream variation of channel characteristics, scaled by flow affects the transport and distribution of heat throughout a large river. As water moves through a river channel, streamflow and velocity may fluctuate by orders of magnitude primarily due to channel geometry, slope and resistance to flow, and the time scales of those fluctuations range from days to decades (Constantz et al., 1994; Lundquist and Cayan, 2002; McKerchar and Henderson, 2003). It is well understood that the heat budget of a river is primarily governed by surface exchanges, with the most significant surface flux coming from net shortwave radiation. The absorption of radiation at a given point in a river is determined by the wavelength-dependent index of refraction, expressed by the angle of refraction and the optical depth as a function of physical depth and the absorption coefficient (Dozier, 1980). Few studies consider the influence of hydrologic alteration to the optical properties governing net radiative heat transfer in a large lowland river, yet it is the most significant component of the heat budget and definitive to a river's thermal regime. We seek a physically based model without calibration to incorporate scale-dependent physical processes governing heat and flow dynamics in large rivers, how they change across the longitudinal profile, and how they change under different flow regimes. Longitudinal flow and heat flux analyses require synoptic flow time series from multiple sites along rivers, and few hydrometric networks meet this requirement (Larned et al, 2011). We model the energy budget in a regulated 240-km mainstem reach of the San Joaquin River California, USA equipped with multiple gaging stations from Friant Dam to its confluence with the Merced River during a large-scale flow experiment. We use detailed hydroclimatic observations distributed across the longitudinal gradient creating a non-replicable field experiment of heat fluxes across a range of flow regime

  13. Recruiting black Americans in a large cohort study: the Adventist Health Study-2 (AHS-2) design, methods and participant characteristics.

    Science.gov (United States)

    Herring, R Patti; Butler, Terry; Hall, Sonja; Montgomery, Susanne B; Fraser, Gary E

    2010-01-01

    The goal of the prospective Adventist Health Study-2 (AHS-2) was to examine the relationship between diet and risk of breast, prostate and colon cancers in Black and White participants. This paper describes the study design, recruitment methods, response rates, and characteristics of Blacks in the AHS-2, thus providing insights about effective strategies to recruit Blacks to participate in research studies. We designed a church-based recruitment model and trained local recruiters who used various strategies to recruit participants in their churches. Participants completed a 50-page self-administered dietary and lifestyle questionnaire. Participants are Black Seventh-day Adventists, aged 30-109 years, and members of 1,209 Black churches throughout the United States and Canada. Approximately 48,328 Blacks from an estimated target group of over 90,000 signed up for the study and 25,087 completed the questionnaire, comprising about 26% of the larger 97,000 AHS-2-member cohort. Participants were diverse in age, geographic location, education, and income. Seventy percent were female with a median age of 59 years. In spite of many recruitment challenges and barriers, we successfully recruited a large cohort whose data should provide some answers as to why Blacks have poorer health outcomes than several other ethnic groups, and help explain existing health disparities.

  14. Recruiting Black Americans in a Large Cohort Study: The Adventist Health Study-2 (AHS-2) Design, Methods and Participant Characteristics

    Science.gov (United States)

    Herring, R. Patti; Butler, Terry; Hall, Sonja; Montgomery, Susanne B.; Fraser, Gary E.

    2011-01-01

    Objective The goal of the prospective Adventist Health Study-2 (AHS-2) was to examine the relationship between diet and risk of breast, prostate and colon cancers in Black and White participants. This paper describes the study design, recruitment methods, response rates, and characteristics of Blacks in the AHS-2, thus providing insights about effective strategies to recruit Blacks to participate in research studies. Design We designed a church-based recruitment model and trained local recruiters who used various strategies to recruit participants in their churches. Participants completed a 50-page self-administered dietary and lifestyle questionnaire. Participants Participants are Black Seventh-day Adventists, aged 30–109 years, and members of 1,209 Black churches throughout the United States and Canada. Results Approximately 48,328 Blacks from an estimated target group of over 90,000 signed up for the study and 25,087 completed the questionnaire, comprising about 26% of the larger 97,000 AHS-2-member cohort. Participants were diverse in age, geographic location, education, and income. Seventy percent were female with a median age of 59 years. Conclusion In spite of many recruitment challenges and barriers, we successfully recruited a large cohort whose data should provide some answers as to why Blacks have poorer health outcomes than several other ethnic groups, and help explain existing health disparities. PMID:21305834

  15. Cycling and Female Sexual and Urinary Function: Results From a Large, Multinational, Cross-Sectional Study.

    Science.gov (United States)

    Gaither, Thomas W; Awad, Mohannad A; Murphy, Gregory P; Metzler, Ian; Sanford, Thomas; Eisenberg, Michael L; Sutcliffe, Siobhan; Osterberg, E Charles; Breyer, Benjamin N

    2018-04-01

    and sampling methods. We found that women cyclists were no more likely to report sexual dysfunction or urinary symptoms than swimmers or runners. Gaither TW, Awad MA, Murphy GP, et al. Cycling and Female Sexual and Urinary Function: Results From a Large, Multinational, Cross-Sectional Study. J Sex Med 2018;15:510-518. Copyright © 2018. Published by Elsevier Inc.

  16. Grid matching of large-scale wind energy conversion systems, alone and in tandem with large-scale photovoltaic systems: An Israeli case study

    International Nuclear Information System (INIS)

    Solomon, A.A.; Faiman, D.; Meron, G.

    2010-01-01

    This paper presents a grid matching analysis of wind energy conversion systems (WECSs) and photovoltaic (PV)-WECS hybrid systems. The study was carried out using hourly load data of the Israel Electric Corporation (IEC) for the year 2006 and the corresponding simulated hourly performance of large PV and WECS plants in the Negev Desert. Our major objective was to compare the grid-matching capabilities of wind with those of our previously published PV results, and to assess the extent to which the combined employment of WECS and PV can improve the grid matching capability of either technology when used on its own. We find that, due to the differences in diurnal and seasonal output profiles of WECS and PV, their tandem employment significantly improves grid penetration compared to their use individually.

  17. State of Hawaii, Department of Health, Clean Water Branch State-wide Water Quality Sampling Dataset 1999-2006 (NODC Accession 0013723)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Monitoring Section of the State of Hawaii, Department of Health, Clean Water Branch collects water quality data at over 300 coastal locations state-wide using...

  18. State of Hawaii, Department of Health, Clean Water Branch State-wide Water Quality Sampling Dataset 1973-1998 (NODC Accession 0013724)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Monitoring Section of the State of Hawaii, Department of Health, Clean Water Branch collects water quality data at over 300 coastal locations state-wide using...

  19. Socioeconomic and travel demand forecasts for Virginia and potential policy responses : a report for VTrans2035 : Virginia's statewide multimodal transportation plan.

    Science.gov (United States)

    2009-01-01

    VTrans2035, Virginia's statewide multimodal transportation plan, requires 25-year forecasts of socioeconomic and travel activity. Between 2010 and 2035, daily vehicle miles traveled (DVMT) will increase between 35% and 45%, accompanied by increases i...

  20. Large Scale Numerical Modelling to Study the Dispersion of Persistent Toxic Substances Over Europe

    Science.gov (United States)

    Aulinger, A.; Petersen, G.

    2003-12-01

    For the past two decades environmental research at the GKSS Research Centre has been concerned with airborne pollutants with adverse effects on human health. The research was mainly focused on investigating the dispersion and deposition of heavy metals like lead and mercury over Europe by means of numerical modelling frameworks. Lead, in particular, served as a model substance to study the relationship between emissions and human exposition. The major source of airborne lead in Germany was fuel combustion until the 1980ies when its use as gasoline additive declined due to political decisions. Since then, the concentration of lead in ambient air and the deposition rates decreased in the same way as the consumption of leaded fuel. These observations could further be related to the decrease of lead concentrations in human blood measured during medical studies in several German cities. Based on the experience with models for heavy metal transport and deposition we have now started to turn our research focus to organic substances, e.g. PAHs. PAHs have been recognized as significant air borne carcinogens for several decades. However, it is not yet possible to precisely quantify the risk of human exposure to those compounds. Physical and chemical data, known from literature, describing the partitioning of the compounds between particle and gas phase and their degradation in the gas phase are implemented in a tropospheric chemistry module. In this way, the fate of PAHs in the atmosphere due to different particle type and size and different meteorological conditions is tested before carrying out large-scale and long-time studies. First model runs have been carried out for Benzo(a)Pyrene as one of the principal carcinogenic PAHs. Up to now, nearly nothing is known about degradation reactions of particle bound BaP. Thus, they could not be taken into account in the model so far. On the other hand, the proportion of BaP in the gas phase has to be considered at higher ambient

  1. Recurrence in Benign Paroxysmal Positional Vertigo: A Large, Single-Institution Study.

    Science.gov (United States)

    Luryi, Alexander L; Lawrence, Juliana; Bojrab, Dennis I; LaRouere, Michael; Babu, Seilesh; Zappia, John; Sargent, Eric W; Chan, Eleanor; Naumann, Ilka; Hong, Robert S; Schutt, Christopher A

    2018-04-11

    To report rates of recurrence in benign paroxysmal positional vertigo (BPPV) and associated patient and disease factors. Retrospective chart review. Single high-volume otology practice. Patients diagnosed with BPPV from 2007 to 2016 with documented resolution of symptoms. Diagnostic and particle repositioning maneuvers for BPPV. BPPV recurrence, time to recurrence, and ear(s) affected at recurrence. A total of 1,105 patients meeting criteria were identified. Of this population, 37% had recurrence of BPPV in either ear or both ears. Overall same-ear recurrence rate was 28%; 76% of recurrences involved the same ear(s) as initial presentation. Recurrences that occurred after longer disease-free intervals were more likely to involve the opposite ear than early recurrences (p = 0.02). Female sex (40.4% versus 32.7%, p = 0.01) and history of previous BPPV (57.5% versus 32.4%, p diabetes mellitus, and traumatic etiology were not. Approximately, half (56%) of recurrences occurred within 1 year of resolution. A large single-institution study of recurrence in BPPV is presented along with Kaplan-Meier disease-free survival curves. Female sex and history of previous BPPV were associated with increased recurrence, while previously suspected risk factors for recurrence including history of Menière's disease, diabetes, and trauma were not. Remote recurrence is more likely to involve the contralateral ear than early recurrence. These data solidify the expected course of treated BPPV allowing for improved clinical care and patient counseling.

  2. Clinical features of tic-related obsessive-compulsive disorder: results from a large multicenter study.

    Science.gov (United States)

    Gomes de Alvarenga, Pedro; de Mathis, Maria Alice; Dominguez Alves, Anna Claudia; do Rosário, Maria Conceição; Fossaluza, Victor; Hounie, Ana Gabriela; Miguel, Euripedes Constantino; Rodrigues Torres, Albina

    2012-06-01

    To evaluate the clinical features of obsessive-compulsive disorder (OCD) patients with comorbid tic disorders (TD) in a large, multicenter, clinical sample. A cross-sectional study was conducted that included 813 consecutive OCD outpatients from the Brazilian OCD Research Consortium and used several instruments of assessment, including the Yale-Brown Obsessive-Compulsive Scale, the Dimensional Yale-Brown Obsessive-Compulsive Scale, the Yale Global Tic Severity Scale (YGTSS), the USP Sensory Phenomena Scale, and the Structured Clinical Interview for DSM-IV Axis I Disorders. The sample mean current age was 34.9 years old (SE 0.54), and the mean age at obsessive-compulsive symptoms (OCS) onset was 12.8 years old (SE 0.27). Sensory phenomena were reported by 585 individuals (72% of the sample). The general lifetime prevalence of TD was 29.0% (n = 236), with 8.9% (n = 72) presenting Tourette syndrome, 17.3% (n = 141) chronic motor tic disorder, and 2.8% (n = 23) chronic vocal tic disorder. The mean tic severity score, according to the YGTSS, was 27.2 (SE 1.4) in the OCD + TD group. Compared to OCD patients without comorbid TD, those with TD (OCD + TD group, n = 236) were more likely to be males (49.2% vs. 38.5%, p disorders in general: separation anxiety disorder, social phobia, specific phobia, generalized anxiety disorder, post-traumatic stress disorder, attention-deficit hyperactivity disorder, impulse control disorders in general, and skin picking. Also, the "aggressive," "sexual/religious," and "hoarding" symptom dimensions were more severe in the OCD + TD group. Tic-related OCD may constitute a particular subgroup of the disorder with specific phenotypical characteristics, but its neurobiological underpinnings remain to be fully disentangled.

  3. Acceptance of Driverless Vehicles: Results from a Large Cross-National Questionnaire Study

    Directory of Open Access Journals (Sweden)

    Sina Nordhoff

    2018-01-01

    Full Text Available Shuttles that operate without an onboard driver are currently being developed and tested in various projects worldwide. However, there is a paucity of knowledge on the determinants of acceptance of driverless shuttles in large cross-national samples. In the present study, we surveyed 10,000 respondents on the acceptance of driverless vehicles and sociodemographic characteristics, using a 94-item online questionnaire. After data filtering, data of 7,755 respondents from 116 countries were retained. Respondents reported that they would enjoy taking a ride in a driverless vehicle (mean = 4.90 on a scale from 1 = disagree strongly to 6 = agree strongly. We further found that the scores on the questionnaire items were most appropriately explained through a general acceptance component, which had loadings of about 0.7 for items pertaining to the usefulness of driverless vehicles and loadings between 0.5 and 0.6 for items concerning the intention to use, ease of use, pleasure, and trust in driverless vehicles, as well as knowledge of mobility-related developments. Additional components were identified as thrill seeking, wanting to be in control manually, supporting a car-free environment, and being comfortable with technology. Correlations between sociodemographic characteristics and general acceptance scores were small (<0.20, yet interpretable (e.g., people who reported difficulty with finding a parking space were more accepting towards driverless vehicles. Finally, we found that the GDP per capita of the respondents’ country was predictive of countries’ mean general acceptance score (ρ=-0.48 across 43 countries with 25 or more respondents. In conclusion, self-reported acceptance of driverless vehicles is more strongly determined by domain-specific attitudes than by sociodemographic characteristics. We recommend further research, using objective measures, into the hypothesis that national characteristics are a predictor of the acceptance of

  4. Influence of atmospheric stability on wind-turbine wakes: A large-eddy simulation study

    Science.gov (United States)

    Abkar, Mahdi; Porté-Agel, Fernando

    2014-05-01

    In this study, large-eddy simulation is combined with a turbine model to investigate the influence of atmospheric stability on wind-turbine wakes. In the simulations, subgrid-scale turbulent fluxes are parameterized using tuning-free Lagrangian scale-dependent dynamic models. These models optimize the local value of the model coefficients based on the dynamics of the resolved scales. The turbine-induced forces are parameterized with an actuator-disk model with rotation. In this technique, blade-element theory is used to calculate the lift and drag forces acting on the blades. Emphasis is placed on the structure and characteristics of wind-turbine wakes in the cases where the incident flows to the turbine have the same mean velocity at the hub height but different stability conditions. The simulation results show that atmospheric stability has a significant effect on the spatial distribution of the mean velocity deficit and turbulent fluxes in the wake region. In particular, the magnitude of the velocity deficit increases with increasing stability in the atmosphere. In addition, the locations of the maximum turbulence intensity and turbulent stresses are closer to the turbine in convective boundary layer compared with neutral and stable ones. Detailed analysis of the resolved turbulent kinetic energy (TKE) budget inside the wake reveals also that the thermal stratification of the incoming wind considerably affects the magnitude and spatial distribution of the turbulent production, transport term and dissipation rate (transfer of energy to the subgrid scales). It is also shown that the near-wake region can be extended to a farther distance downstream in stable condition compared with neutral and unstable counterparts. In order to isolate the effect of atmospheric stability, additional simulations of neutrally-stratified atmospheric boundary layers are performed with the same turbulence intensity at hub height as convective and stable ones. The results show that the

  5. Cutaneous melanoma in situ: translational evidence from a large population-based study.

    Science.gov (United States)

    Mocellin, Simone; Nitti, Donato

    2011-01-01

    Cutaneous melanoma in situ (CMIS) is a nosologic entity surrounded by health concerns and unsolved debates. We aimed to shed some light on CMIS by means of a large population-based study. Patients with histologic diagnosis of CMIS were identified from the Surveillance Epidemiology End Results (SEER) database. The records of 93,863 cases of CMIS were available for analysis. CMIS incidence has been steadily increasing over the past 3 decades at a rate higher than any other in situ or invasive tumor, including invasive skin melanoma (annual percentage change [APC]: 9.5% versus 3.6%, respectively). Despite its noninvasive nature, CMIS is treated with excision margins wider than 1 cm in more than one third of cases. CMIS is associated with an increased risk of invasive melanoma (standardized incidence ratio [SIR]: 8.08; 95% confidence interval [CI]: 7.66-8.57), with an estimated 3:5 invasive/in situ ratio; surprisingly, it is also associated with a reduced risk of gastrointestinal (SIR: 0.78, CI: 0.72-0.84) and lung (SIR: 0.65, CI: 0.59-0.71) cancers. Relative survival analysis shows that persons with CMIS have a life expectancy equal to that of the general population. CMIS is increasingly diagnosed and is often overtreated, although it does not affect the life expectancy of its carriers. Patients with CMIS have an increased risk of developing invasive melanoma (which warrants their enrollment in screening programs) but also a reduced risk of some epithelial cancers, which raises the intriguing hypothesis that genetic/environmental risk factors for some tumors may oppose the pathogenesis of others.

  6. Water and nutrient balances in a large tile-drained agricultural catchment: a distributed modeling study

    Directory of Open Access Journals (Sweden)

    H. Li

    2010-11-01

    Full Text Available This paper presents the development and implementation of a distributed model of coupled water nutrient processes, based on the representative elementary watershed (REW approach, to the Upper Sangamon River Basin, a large, tile-drained agricultural basin located in central Illinois, mid-west of USA. Comparison of model predictions with the observed hydrological and biogeochemical data, as well as regional estimates from literature studies, shows that the model is capable of capturing the dynamics of water, sediment and nutrient cycles reasonably well. The model is then used as a tool to gain insights into the physical and chemical processes underlying the inter- and intra-annual variability of water and nutrient balances. Model predictions show that about 80% of annual runoff is contributed by tile drainage, while the remainder comes from surface runoff (mainly saturation excess flow and subsurface runoff. It is also found that, at the annual scale nitrogen storage in the soil is depleted during wet years, and is supplemented during dry years. This carryover of nitrogen storage from dry year to wet year is mainly caused by the lateral loading of nitrate. Phosphorus storage, on the other hand, is not affected much by wet/dry conditions simply because the leaching of it is very minor compared to the other mechanisms taking phosphorous out of the basin, such as crop harvest. The analysis then turned to the movement of nitrate with runoff. Model results suggested that nitrate loading from hillslope into the channel is preferentially carried by tile drainage. Once in the stream it is then subject to in-stream denitrification, the significant spatio-temporal variability of which can be related to the variation of the hydrologic and hydraulic conditions across the river network.

  7. Predicting the evolution of large cholera outbreaks: lessons learnt from the Haiti case study

    Science.gov (United States)

    Bertuzzo, Enrico; Mari, Lorenzo; Righetto, Lorenzo; Knox, Allyn; Finger, Flavio; Casagrandi, Renato; Gatto, Marino; Rodriguez-Iturbe, Ignacio; Rinaldo, Andrea

    2013-04-01

    Mathematical models can provide key insights into the course of an ongoing epidemic, potentially aiding real-time emergency management in allocating health care resources and possibly anticipating the impact of alternative interventions. Spatially explicit models of waterborne disease are made routinely possible by widespread data mapping of hydrology, road network, population distribution, and sanitation. Here, we study the ex-post reliability of predictions of the ongoing Haiti cholera outbreak. Our model consists of a set of dynamical equations (SIR-like, i.e. subdivided into the compartments of Susceptible, Infected and Recovered individuals) describing a connected network of human communities where the infection results from the exposure to excess concentrations of pathogens in the water, which are, in turn, driven by hydrologic transport through waterways and by mobility of susceptible and infected individuals. Following the evidence of a clear correlation between rainfall events and cholera resurgence, we test a new mechanism explicitly accounting for rainfall as a driver of enhanced disease transmission by washout of open-air defecation sites or cesspool overflows. A general model for Haitian epidemic cholera and the related uncertainty is thus proposed and applied to the dataset of reported cases now available. The model allows us to draw predictions on longer-term epidemic cholera in Haiti from multi-season Monte Carlo runs, carried out up to January 2014 by using a multivariate Poisson rainfall generator, with parameters varying in space and time. Lessons learned and open issues are discussed and placed in perspective. We conclude that, despite differences in methods that can be tested through model-guided field validation, mathematical modeling of large-scale outbreaks emerges as an essential component of future cholera epidemic control.

  8. A computational study of ethylene–air sooting flames: Effects of large polycyclic aromatic hydrocarbons

    KAUST Repository

    Selvaraj, Prabhu

    2015-11-05

    An updated reduced gas-phase kinetic mechanism was developed and integrated with aerosol models to predict soot formation characteristics in ethylene nonpremixed and premixed flames. A primary objective is to investigate the sensitivity of the soot formation to various chemical pathways for large polycyclic aromatic hydrocarbons (PAH). The gas-phase chemical mechanism adopted the KAUST-Aramco PAH Mech 1.0, which utilized the AramcoMech 1.3 for gas-phase reactions validated for up to C2 fuels. In addition, PAH species up to coronene (C24H12 or A7) were included to describe the detailed formation pathways of soot precursors. In this study, the detailed chemical mechanism was reduced from 397 to 99 species using directed relation graph with expert knowledge (DRG-X) and sensitivity analysis. The method of moments with interpolative closure (MOMIC) was employed for the soot aerosol model. Counterflow nonpremixed flames at low strain rate sooting conditions were considered, for which the sensitivity of soot formation characteristics to different nucleation pathways were investigated. Premixed flame experiment data at different equivalence ratios were also used for validation. The findings show that higher PAH concentrations result in a higher soot nucleation rate, and that the total soot volume and average size of the particles are predicted in good agreement with experimental results. Subsequently, the effects of different pathways, with respect to pyrene- or coronene-based nucleation models, on the net soot formation rate were analyzed. It was found that the nucleation processes (i.e., soot inception) are sensitive to the choice of PAH precursors, and consideration of higher PAH species beyond pyrene is critical for accurate prediction of the overall soot formation.

  9. A large cross-sectional community-based study of newborn care practices in southern Tanzania.

    Directory of Open Access Journals (Sweden)

    Suzanne Penfold

    Full Text Available Despite recent improvements in child survival in sub-Saharan Africa, neonatal mortality rates remain largely unchanged. This study aimed to determine the frequency of delivery and newborn-care practices in southern Tanzania, where neonatal mortality is higher than the national average. All households in five districts of Southern Tanzania were approached to participate. Of 213,220 female residents aged 13-49 years, 92% participated. Cross-sectional, retrospective data on childbirth and newborn care practices were collected from 22,243 female respondents who had delivered a live baby in the preceding year. Health facility deliveries accounted for 41% of births, with nearly all non-facility deliveries occurring at home (57% of deliveries. Skilled attendants assisted 40% of births. Over half of women reported drying the baby and over a third reported wrapping the baby within 5 minutes of delivery. The majority of mothers delivering at home reported that they had made preparations for delivery, including buying soap (84% and preparing a cloth for drying the child (85%. Although 95% of these women reported that the cord was cut with a clean razor blade, only half reported that it was tied with a clean thread. Furthermore, out of all respondents 10% reported that their baby was dipped in cold water immediately after delivery, around two-thirds reported bathing their babies within 6 hours of delivery, and 28% reported putting something on the cord to help it dry. Skin-to-skin contact between mother and baby after delivery was rarely practiced. Although 83% of women breastfed within 24 hours of delivery, only 18% did so within an hour. Fewer than half of women exclusively breastfed in the three days after delivery. The findings suggest a need to promote and facilitate health facility deliveries, hygienic delivery practices for home births, delayed bathing and immediate and exclusive breastfeeding in Southern Tanzania to improve newborn health.

  10. Epidemiological study of air filtration systems for preventing PRRSV infection in large sow herds.

    Science.gov (United States)

    Alonso, Carmen; Murtaugh, Michael P; Dee, Scott A; Davies, Peter R

    2013-10-01

    Porcine reproductive and respiratory syndrome virus (PRRSV) is the most economically significant pathogen in the US swine industry. Aerosol transmission among herds is a major concern in pig dense regions and filtration of incoming air, in combination with standard biosecurity procedures, has been demonstrated to prevent transmission of PRRSV into susceptible herds. To quantify the impact of air filtration on reducing risk of PRRSV outbreaks, we compared the incidence rate of new PRRSV introductions in 20 filtered and 17 non-filtered control sow herds in a swine dense region of North America during a 7 year study period. Events of novel virus introduction were ascertained by phylogenetic analysis of PRRSV ORF5 gene sequences. Putative new viruses were defined as exogenous (introduced) based on ORF5 nucleotide sequence differences compared to previous farm isolates. The influence of sequence difference cut-off values ranging from 2 to 10% on case definition and relative risk were evaluated. Non-filtered farms incurred about 0.5 outbreaks per year, with a seasonal increase in risk in cooler periods. Baseline risk, prior to filtration, in treatment farms was approximately 0.75 per year, approximately 50% higher than in control farms. Air filtration significantly reduced risk of PRRSV introduction events to 0.06-0.22 outbreaks per year, depending on the cut-off values used to classify a virus isolate as new to the herd. Overall, air filtration led to an approximately 80% reduction in risk of introduction of novel PRRSV, indicating that on large sow farms with good biosecurity in swine-dense regions, approximately four-fifths of PRRSV outbreaks may be attributable to aerosol transmission. Copyright © 2013 Elsevier B.V. All rights reserved.

  11. Analyzing large data sets acquired through telemetry from rats exposed to organophosphorous compounds: an EEG study.

    Science.gov (United States)

    de Araujo Furtado, Marcio; Zheng, Andy; Sedigh-Sarvestani, Madineh; Lumley, Lucille; Lichtenstein, Spencer; Yourick, Debra

    2009-10-30

    The organophosphorous compound soman is an acetylcholinesterase inhibitor that causes damage to the brain. Exposure to soman causes neuropathology as a result of prolonged and recurrent seizures. In the present study, long-term recordings of cortical EEG were used to develop an unbiased means to quantify measures of seizure activity in a large data set while excluding other signal types. Rats were implanted with telemetry transmitters and exposed to soman followed by treatment with therapeutics similar to those administered in the field after nerve agent exposure. EEG, activity and temperature were recorded continuously for a minimum of 2 days pre-exposure and 15 days post-exposure. A set of automatic MATLAB algorithms have been developed to remove artifacts and measure the characteristics of long-term EEG recordings. The algorithms use short-time Fourier transforms to compute the power spectrum of the signal for 2-s intervals. The spectrum is then divided into the delta, theta, alpha, and beta frequency bands. A linear fit to the power spectrum is used to distinguish normal EEG activity from artifacts and high amplitude spike wave activity. Changes in time spent in seizure over a prolonged period are a powerful indicator of the effects of novel therapeutics against seizures. A graphical user interface has been created that simultaneously plots the raw EEG in the time domain, the power spectrum, and the wavelet transform. Motor activity and temperature are associated with EEG changes. The accuracy of this algorithm is also verified against visual inspection of video recordings up to 3 days after exposure.

  12. SU-E-T-531: Large--Scale DVH Quality Study: Correlated Aims Lead Relaxations

    Energy Technology Data Exchange (ETDEWEB)

    Nohadani, O; Roy, A [Northwestern University, Evanston, IL (United States); Das, I [Indiana University- School of Medicine, Indianapolis, IN (United States)

    2015-06-15

    Purpose: Intensity modulated radiation therapy plans are designed to optimally target a tumor while sparing surrounding tissue. Desired dose distributions are iteratively approached via inverse planning. This leads to tradeoffs between clinical objectives for the planning target volume (PTV), organs at risk, and normal tissues. Dose volume histogram (DVHs) related aims are followed that are either institutional or internationally recommended. We analyze common goals and identify potential reasons that often lead to tradeoffs. Methods: 524 IMRT plans for various tumor sites were analyzed based on the main institutional DVH goal for PTV (D95) and the recommendations by ICRU-83 (D2, D50, and D98). Robust statistical tools are developed and applied to ensure that the results are immune to data uncertainties. The probability of violation was measured for each of the DVH goals based on the frequency of not meeting recommended doses. Conditional probabilities for satisfying and/or violating DVH aims were computed to test the hypothesized pair-wise relations between DVH aims. For example, for plans that satisfied D50, the probability of violating D98 was computed via P(D98 < 95% | 98% ≤ D50 ≤ 102%). The equality constraint D50 = 100% was relaxed to encompass the range [98,102]%. Results: A large majority of cases (88%) satisfied the institutional goal for PTV of D95 ≤ 95%. Similar consensus existed for D98. 51% of cases satisfied D2 ≥ 107%. However, only 18% of cases satisfied D50. The conditional probability showed correlations amongst the studied DVH goals. In fact, a negative correlation was revealed between D50 and D95 (and D98), suggesting that these competing goals cannot be satisfied concurrently. Conclusion: The majority of plans followed the institutional guidelines. The reason for their deviation from international recommendations seems to be that the latter goals are competing and cannot be satisfied concurrently in clinical practice.

  13. Large-scale laboratory study of breaking wave hydrodynamics over a fixed bar

    Science.gov (United States)

    van der A, Dominic A.; van der Zanden, Joep; O'Donoghue, Tom; Hurther, David; Cáceres, Iván.; McLelland, Stuart J.; Ribberink, Jan S.

    2017-04-01

    A large-scale wave flume experiment has been carried out involving a T = 4 s regular wave with H = 0.85 m wave height plunging over a fixed barred beach profile. Velocity profiles were measured at 12 locations along the breaker bar using LDA and ADV. A strong undertow is generated reaching magnitudes of 0.8 m/s on the shoreward side of the breaker bar. A circulation pattern occurs between the breaking area and the inner surf zone. Time-averaged turbulent kinetic energy (TKE) is largest in the breaking area on the shoreward side of the bar where the plunging jet penetrates the water column. At this location, and on the bar crest, TKE generated at the water surface in the breaking process reaches the bottom boundary layer. In the breaking area, TKE does not reduce to zero within a wave cycle which leads to a high level of "residual" turbulence and therefore lower temporal variation in TKE compared to previous studies of breaking waves on plane beach slopes. It is argued that this residual turbulence results from the breaker bar-trough geometry, which enables larger length scales and time scales of breaking-generated vortices and which enhances turbulence production within the water column compared to plane beaches. Transport of TKE is dominated by the undertow-related flux, whereas the wave-related and turbulent fluxes are approximately an order of magnitude smaller. Turbulence production and dissipation are largest in the breaker zone and of similar magnitude, but in the shoaling zone and inner surf zone production is negligible and dissipation dominates.

  14. Cohort Profile of The GOALS Study: A Large-scale Research of Physical Activity in Dutch Students

    NARCIS (Netherlands)

    De Groot, Renate; Van Dijk, Martin; Kirschner, Paul A.

    2016-01-01

    The GOALS study (Grootschalig Onderzoek naar Activiteiten van Limburgse Scholieren [Large-scale Research of Activities in Dutch Students]) was set up to investigate possible associations between different forms of physical activity and inactivity with cognitive performance, academic achievement and

  15. Plant protection system optimization studies to mitigate consequences of large breaks in the Advanced Neutron Source Reactor

    International Nuclear Information System (INIS)

    Khayat, M.I.; March-Leuba, J.

    1993-01-01

    This paper documents some of the optimization studies performed to maximize the performance of the engineered safety features and scram systems to mitigate the consequences of large breaks in the primary cooling system of the Advanced Neutron Source (ANS) Reactor

  16. Prospective study of bone metastasis from prostate cancer: comparison between large field diffusion-weighted imaging and bone scintigraphy

    International Nuclear Information System (INIS)

    Wang Xiaoying; Zhang Chunyan; Jiang Xuexiang

    2009-01-01

    Objective: To evaluate the large field diffusion weighted imaging (DWI) (from head vertex to lower leg) in detection of bone metastases from prostate cancer. Methods: One hundred and sixty- six consecutive patients who were suspected of prostate cancer received pelvic MRI and large field diffusion weighted imaging examination. Forty-nine of them underwent bone scintigraphy within one month of the examination of large field DWI. The images were double-blindly evaluated without the knowledge of the pathology result. Conventional MR T 1 and fat saturation T 2 weighted images were taken as standard for the diagnosis of bone metastasis. The sensitivity, specificity, and area under curve between large field DWI and bone scintigraphy were compared with McNemar test. Five patients with bone metastases exceeding 10 per patient were excluded in the lesion-by-lesion analysis. Results: Ten of the 49 patients were diagnosed as bone metastases. The diagnosis of bone metastasis were made in 15 patients by large field DWI and in 17 patients by bone scintigraphy. With patient number as study units (n=49), the diagnostic sensitivity of bone metastases with large field DWI and bone metastases were both 100% (10/10), and specificity were 87.2% (34/39) vs. 82.1% (32/39), respectively. ROC study showed the area under curve (AUC) of large field DWI and bone scintigraphy were 0.936 vs. 0.910, respectively. Totally 68 abnormal foci were identified from large field DWI and/or bone scintigraphy in 44 patients (while 5 patients with bone metastases exceeding 10 foci per patient were excluded), 20 of them were diagnosed as foci of bone metastasis. The diagnosis of bone metastases was made in 23 foci by large field DWI and in 34 by bone scintigraphy. With lesion numbers as study units (n=68), the diagnostic sensitivity of large field DWI and bone scintigraphy were both 90.0% (18/20), and specificity were 89.6% (43/48) vs. 66.7% (32/48), respectively. ROC study showed the area under curve of

  17. Familiality of co-existing ADHD and tic disorders: evidence from a large sibling study

    Directory of Open Access Journals (Sweden)

    Veit Roessner

    2016-07-01

    Full Text Available AbstractBackground: The association of attention-deficit/hyperactivity disorder (ADHD and tic disorder (TD is frequent and clinically important. Very few and inconclusive attempts have been made to clarify if and how the combination of ADHD+TD runs in families. Aim: To determine the first time in a large-scale ADHD sample whether ADHD+TD increases the risk of ADHD+TD in siblings and, also the first time, if this is independent of their psychopathological vulnerability in general. Methods: The study is based on the International Multicenter ADHD Genetics (IMAGE study. The present sub-sample of 2815 individuals included ADHD-index patients with co-existing TD (ADHD+TD, n=262 and without TD (ADHD-TD, n=947 as well as their 1606 full siblings (n=358 of the ADHD+TD index patients and n=1248 of the ADHD-TD index patients. We assessed psychopathological symptoms in index patients and siblings by using the strength and difficulties questionnaire (SDQ and the parent and teacher Conners’ long version Rating Scales (CRS. For disorder classification the Parental Account of Childhood Symptoms (PACS-Interview was applied in n = 271 children. Odds ratio with the GENMOD procedure (PROCGENMOD was used to test if the risk for ADHD, TD and ADHD+TD in siblings was associated with the related index patients’ diagnoses. In order to get an estimate for specificity we compared the four groups for general psychopathological symptoms.Results: Co-existing ADHD+TD in index patients increased the risk of both comorbid ADHD+TD and TD in the siblings of these index patients. These effects did not extend to general psychopathology. Interpretation: Co-existence of ADHD+TD may segregate in families. The same holds true for TD (without ADHD. Hence, the segregation of TD (included in both groups seems to be the determining factor, independent of further behavioral problems. This close relationship between ADHD and TD supports the clinical approach to carefully assess ADHD in

  18. VUV photoemission studies of candidate Large Hadron Collider vacuum chamber materials

    Directory of Open Access Journals (Sweden)

    R. Cimino

    1999-06-01

    Full Text Available In the context of future accelerators and, in particular, the beam vacuum of the Large Hadron Collider (LHC, a 27 km circumference proton collider to be built at CERN, VUV synchrotron radiation (SR has been used to study both qualitatively and quantitatively candidate vacuum chamber materials. Emphasis is given to show that angle and energy resolved photoemission is an extremely powerful tool to address important issues relevant to the LHC, such as the emission of electrons that contributes to the creation of an electron cloud which may cause serious beam instabilities and unmanageable heat loads on the cryogenic system. Here we present not only the measured photoelectron yields from the proposed materials, prepared on an industrial scale, but also the energy and in some cases the angular dependence of the emitted electrons when excited with either a white light (WL spectrum, simulating that in the arcs of the LHC, or monochromatic light in the photon energy range of interest. The effects on the materials examined of WL irradiation and /or ion sputtering, simulating the SR and ion bombardment expected in the LHC, were investigated. The studied samples exhibited significant modifications, in terms of electron emission, when exposed to the WL spectrum from the BESSY Toroidal Grating Monochromator beam line. Moreover, annealing and ion bombardment also induce substantial changes to the surface thereby indicating that such surfaces would not have a constant electron emission during machine operation. Such characteristics may be an important issue to define the surface properties of the LHC vacuum chamber material and are presented in detail for the various samples analyzed. It should be noted that all the measurements presented here were recorded at room temperature, whereas the majority of the LHC vacuum system will be maintained at temperatures below 20 K. The results cannot therefore be directly applied to these sections of the machine until

  19. A Feasibility Study on Core Cooling of Reduced-Moderation PWR for the Large Break LOCA

    International Nuclear Information System (INIS)

    Hiroyuki Yoshida; Akira Ohnuki; Hajime Akimoto

    2002-01-01

    A design study of a reduced-moderation water reactor (RMWR) with tight lattice core is being carried out at the Japan Atomic Energy Research Institute (JAERI) as one candidate for future reactors. The concept is developed to achieve a conversion ratio greater than unity using the tight lattice core (volume ratio of moderator to fuel is around 0.5 and the gap spacing between the fuel rods is remarkably narrower than in a reactor currently operated). Under such tight configuration, the core thermal margin becomes smaller and should be evaluated in a normal operation and also during the reflood phase in a large break loss-of-coolant accident (LBLOCA) for PWR type reactors. In this study, we have performed a feasibility evaluation on core cooling of reduced moderation PWR for the LBLOCA (200% break). The evaluation was performed for the primary system after the break by the REFLA/TRAC code. The core thermal output of the reduced moderation PWR is 2900 MWt, the gap between adjacent fuel rods is 1 mm, and heavy water is used as the moderator and coolant. The present design adopts seed fuel assemblies (MOX fuel) and several blanket fuel assemblies. In the blanket fuel assemblies, power density is lower than that of the seed fuel assemblies. Then, we set a channel box to each fuel assembly in order to adjust the flow rate in each assembly, because the possibility that the coolant boils in the seed fuel assemblies is very high. The pressure vessel diameter is bigger in comparison with a current PWR and core height is smaller than the current one. The current 4-loop PWR system is used, and, however, to fit into the bigger pressure vessel volume (about 1.5 times), we set up the capacity of the accumulator (1.5 times of the current PWR). Although the maximum clad temperature reached at about 1200 K in the position of 0.6 m from the lower core support plate, it is sufficiently lower than the design criteria of the current PWR (1500 K). The core cooling of the reduced moderation

  20. Shear wave elastography of thyroid nodules for the prediction of malignancy in a large scale study

    Energy Technology Data Exchange (ETDEWEB)

    Park, Ah Young; Son, Eun Ju [Department of Radiology, Yonsei University College of Medicine, Gangnam Severance Hospital, Seoul (Korea, Republic of); Han, Kyunghwa [Biostatistics Collaboration Unit, Gangnam Medical Research Center, Yonsei University College of Medicine, Gangnam Severance Hospital, Seoul (Korea, Republic of); Youk, Ji Hyun [Department of Radiology, Yonsei University College of Medicine, Gangnam Severance Hospital, Seoul (Korea, Republic of); Kim, Jeong-Ah, E-mail: chrismd@hanmail.net [Department of Radiology, Yonsei University College of Medicine, Gangnam Severance Hospital, Seoul (Korea, Republic of); Park, Cheong Soo [Department of Surgery, Yonsei University College of Medicine, Gangnam Severance Hospital, Seoul (Korea, Republic of)

    2015-03-15

    Highlights: •Elasticity indices of malignant thyroid nodules were higher than those of benign. •High elasticity indices were the independent predictors of thyroid malignancy. •SWE evaluation could be useful as adjunctive tool for thyroid cancer diagnosis. -- Abstract: Objectives: The purpose of this study is to validate the usefulness of shear wave elastography (SWE) in predicting thyroid malignancy with a large-scale quantitative SWE data. Methods: This restrospective study included 476 thyroid nodules in 453 patients who underwent gray-scale US and SWE before US-guided fine-needle aspiration biopsy (US-FNA) or surgical excision were included. Gray-scale findings and SWE elasticity indices (EIs) were retrospectively reviewed and compared between benign and malignant thyroid nodules. The optimal cut-off values of EIs for predicting malignancy were determined. The diagnostic performances of gray-scale US and SWE for predicting malignancy were analyzed. The diagnostic performance was compared between the gray-scale US findings only and the combined use of gray-scale US findings with SWEs. Results: All EIs of malignant thyroid nodules were significantly higher than those of benign nodules (p ≤ .001). The optimal cut-off value of each EI for predicting malignancy was 85.2 kPa of E{sub mean}, 94.0 kPa of E{sub max}, 54.0 kPa of E{sub min}. E{sub mean} (OR 3.071, p = .005) and E{sub max} (OR 3.015, p = .003) were the independent predictors of thyroid malignancy. Combined use of gray-scale US findings and each EI showed elevated sensitivity (95.0–95.5% vs 92.9%, p ≤ .005) and AUC (0.820–0.834 vs 0.769, p ≤ .005) for predicting malignancy, compared with the use of only gray-scale US findings. Conclusions: Quantitative parameters of SWE were the independent predictors of thyroid malignancy and SWE evaluation combined with gray-scale US was adjunctive to the diagnostic performance of gray-scale US for predicting thyroid malignancy.

  1. Diabetic foot complications and their risk factors from a large retrospective cohort study.

    Directory of Open Access Journals (Sweden)

    Khalid Al-Rubeaan

    Full Text Available Foot complications are considered to be a serious consequence of diabetes mellitus, posing a major medical and economical threat. Identifying the extent of this problem and its risk factors will enable health providers to set up better prevention programs. Saudi National Diabetes Registry (SNDR, being a large database source, would be the best tool to evaluate this problem.This is a cross-sectional study of a cohort of 62,681 patients aged ≥ 25 years from SNDR database, selected for studying foot complications associated with diabetes and related risk factors.The overall prevalence of diabetic foot complications was 3.3% with 95% confidence interval (95% CI of (3.16%-3.44%, whilst the prevalences of foot ulcer, gangrene, and amputations were 2.05% (1.94%-2.16%, 0.19% (0.16%-0.22%, and 1.06% (0.98%-1.14%, respectively. The prevalence of foot complications increased with age and diabetes duration predominantly amongst the male patients. Diabetic foot is more commonly seen among type 2 patients, although it is more prevalent among type 1 diabetic patients. The Univariate analysis showed Charcot joints, peripheral vascular disease (PVD, neuropathy, diabetes duration ≥ 10 years, insulin use, retinopathy, nephropathy, age ≥ 45 years, cerebral vascular disease (CVD, poor glycemic control, coronary artery disease (CAD, male gender, smoking, and hypertension to be significant risk factors with odds ratio and 95% CI at 42.53 (18.16-99.62, 14.47 (8.99-23.31, 12.06 (10.54-13.80, 7.22 (6.10-8.55, 4.69 (4.28-5.14, 4.45 (4.05-4.89, 2.88 (2.43-3.40, 2.81 (2.31-3.43, 2.24 (1.98-2.45, 2.02 (1.84-2.22, 1.54 (1.29-1.83, and 1.51 (1.38-1.65, respectively.Risk factors for diabetic foot complications are highly prevalent; they have put these complications at a higher rate and warrant primary and secondary prevention programs to minimize morbidity and mortality in addition to economic impact of the complications. Other measurements, such as decompression of lower

  2. Shear wave elastography of thyroid nodules for the prediction of malignancy in a large scale study

    International Nuclear Information System (INIS)

    Park, Ah Young; Son, Eun Ju; Han, Kyunghwa; Youk, Ji Hyun; Kim, Jeong-Ah; Park, Cheong Soo

    2015-01-01

    Highlights: •Elasticity indices of malignant thyroid nodules were higher than those of benign. •High elasticity indices were the independent predictors of thyroid malignancy. •SWE evaluation could be useful as adjunctive tool for thyroid cancer diagnosis. -- Abstract: Objectives: The purpose of this study is to validate the usefulness of shear wave elastography (SWE) in predicting thyroid malignancy with a large-scale quantitative SWE data. Methods: This restrospective study included 476 thyroid nodules in 453 patients who underwent gray-scale US and SWE before US-guided fine-needle aspiration biopsy (US-FNA) or surgical excision were included. Gray-scale findings and SWE elasticity indices (EIs) were retrospectively reviewed and compared between benign and malignant thyroid nodules. The optimal cut-off values of EIs for predicting malignancy were determined. The diagnostic performances of gray-scale US and SWE for predicting malignancy were analyzed. The diagnostic performance was compared between the gray-scale US findings only and the combined use of gray-scale US findings with SWEs. Results: All EIs of malignant thyroid nodules were significantly higher than those of benign nodules (p ≤ .001). The optimal cut-off value of each EI for predicting malignancy was 85.2 kPa of E mean , 94.0 kPa of E max , 54.0 kPa of E min . E mean (OR 3.071, p = .005) and E max (OR 3.015, p = .003) were the independent predictors of thyroid malignancy. Combined use of gray-scale US findings and each EI showed elevated sensitivity (95.0–95.5% vs 92.9%, p ≤ .005) and AUC (0.820–0.834 vs 0.769, p ≤ .005) for predicting malignancy, compared with the use of only gray-scale US findings. Conclusions: Quantitative parameters of SWE were the independent predictors of thyroid malignancy and SWE evaluation combined with gray-scale US was adjunctive to the diagnostic performance of gray-scale US for predicting thyroid malignancy

  3. Diabetic Foot Complications and Their Risk Factors from a Large Retrospective Cohort Study

    Science.gov (United States)

    Al-Rubeaan, Khalid; Al Derwish, Mohammad; Ouizi, Samir; Youssef, Amira M.; Subhani, Shazia N.; Ibrahim, Heba M.; Alamri, Bader N.

    2015-01-01

    Background Foot complications are considered to be a serious consequence of diabetes mellitus, posing a major medical and economical threat. Identifying the extent of this problem and its risk factors will enable health providers to set up better prevention programs. Saudi National Diabetes Registry (SNDR), being a large database source, would be the best tool to evaluate this problem. Methods This is a cross-sectional study of a cohort of 62,681 patients aged ≥25 years from SNDR database, selected for studying foot complications associated with diabetes and related risk factors. Results The overall prevalence of diabetic foot complications was 3.3% with 95% confidence interval (95% CI) of (3.16%–3.44%), whilst the prevalences of foot ulcer, gangrene, and amputations were 2.05% (1.94%–2.16%), 0.19% (0.16%–0.22%), and 1.06% (0.98%–1.14%), respectively. The prevalence of foot complications increased with age and diabetes duration predominantly amongst the male patients. Diabetic foot is more commonly seen among type 2 patients, although it is more prevalent among type 1 diabetic patients. The Univariate analysis showed Charcot joints, peripheral vascular disease (PVD), neuropathy, diabetes duration ≥10 years, insulin use, retinopathy, nephropathy, age ≥45 years, cerebral vascular disease (CVD), poor glycemic control, coronary artery disease (CAD), male gender, smoking, and hypertension to be significant risk factors with odds ratio and 95% CI at 42.53 (18.16–99.62), 14.47 (8.99–23.31), 12.06 (10.54–13.80), 7.22 (6.10–8.55), 4.69 (4.28–5.14), 4.45 (4.05–4.89), 2.88 (2.43–3.40), 2.81 (2.31–3.43), 2.24 (1.98–2.45), 2.02 (1.84–2.22), 1.54 (1.29–1.83), and 1.51 (1.38–1.65), respectively. Conclusions Risk factors for diabetic foot complications are highly prevalent; they have put these complications at a higher rate and warrant primary and secondary prevention programs to minimize morbidity and mortality in addition to economic impact

  4. NIAC Phase I Study Final Report on Large Ultra-Lightweight Photonic Muscle Space Structures

    Science.gov (United States)

    Ritter, Joe

    2016-01-01

    The research goal is to develop new tools support NASA's mission of understanding of the Cosmos by developing cost effective solutions that yield a leap in performance and science data. 'Maikalani' in Hawaiian translates to, "knowledge we gain from the cosmos." Missions like Hubble have fundamentally changed humanity's view of the cosmos. Last year's Nobel prize in physics was a result of astronomical discoveries. $9B class JWST size (6.5 meter diameter) space telescopes, when launched are anticipated to rewrite our knowledge of physics. Here we report on a neoteric meta-material telescope mirror technology designed to enable a factor of 100 or more reduction in areal density, a factor of 100 reduction in telescope production and launch costs as well as other advantages; a leap to enable missions to image the cosmos in unprecedented detail, with the associated gain in knowledge. Whether terahertz, visible or X-ray, reflectors used for high quality electromagnetic imaging require shape accuracy (surface figure) to far better than 1 wavelength (lambda) of the incident photons, more typically lambda/10 or better. Imaging visible light therefore requires mirror surfaces that approximate a desired curve (e.g. a sphere or paraboloid) with smooth shape deviation of th less than approximately 1/1000 the diameter of a human hair. This requires either thick high modulus material like glass or metal, or actuators to control mirror shape. During Phase I our team studied a novel solution to this systems level design mass/shape tradespace requirement both to advance the innovative space technology concept and also to help NASA and other agencies meet current operational and future mission requirements. Extreme and revolutionary NASA imaging missions such as Terrestrial Planet Imager (TPI) require lightweight mirrors with minimum diameters of 20 to 40 meters. For reference, NASA's great achievement; the Hubble space telescope, is only 2.4 meters in diameter. What is required is a

  5. Numerical Study of Piping Limits for Installation of Large Diameter Buckets in Layered Sand

    DEFF Research Database (Denmark)

    Ibsen, Lars Bo; Thilsted, C.L.

    2010-01-01

    The bucket foundations, often referred as ‘suction caissons’, are large cylindrical structures, typically made in steel. The bucket foundations have the potential to be the cost-effective option for offshore wind turbines, if suction assisted penetration is employed. Suction installation may cause...... gradients developing in response to applied suction and the results are presented as simple closed form solutions useful for evaluation of suction thresholds against piping. These close form solutions are compared with large scale model test, performed in a natural seabed at a test site in Frederikshavn...

  6. Application and study of advanced network technology in large container inspection system

    International Nuclear Information System (INIS)

    Li Zheng; Kang Kejun; Gao Wenhuan; Wang Jingjin

    1996-01-01

    Large Container Inspection System (LCIS) based on radiation imaging technology is a powerful tool for the customs to check the contents inside a large container without opening it. An image distributed network system is composed of center manager station, image acquisition station, environment control station, inspection processing station, check-in station, check-out station, database station by using advanced network technology. Mass data, such as container image data, container general information, manifest scanning data, commands and status, must be on-line transferred between different stations. Advanced network technology and software programming technique are presented

  7. Characterization of large-insert DNA libraries from soil for environmental genomic studies of Archaea

    DEFF Research Database (Denmark)

    Treusch, Alexander H; Kletzin, Arnulf; Raddatz, Guenter

    2004-01-01

    Complex genomic libraries are increasingly being used to retrieve complete genes, operons or large genomic fragments directly from environmental samples, without the need to cultivate the respective microorganisms. We report on the construction of three large-insert fosmid libraries in total...... (approximately 1% each) have been captured in our libraries. The diversity of putative protein-encoding genes, as reflected by their distribution into different COG clusters, was comparable to that encoded in complete genomes of cultivated microorganisms. A huge variety of genomic fragments has been captured...

  8. Correspondence of biological condition models of California streams at statewide and regional scales

    Science.gov (United States)

    May, Jason T.; Brown, Larry R.; Rehn, Andrew C.; Waite, Ian R.; Ode, Peter R; Mazor, Raphael D; Schiff, Kenneth C

    2015-01-01

    We used boosted regression trees (BRT) to model stream biological condition as measured by benthic macroinvertebrate taxonomic completeness, the ratio of observed to expected (O/E) taxa. Models were developed with and without exclusion of rare taxa at a site. BRT models are robust, requiring few assumptions compared with traditional modeling techniques such as multiple linear regression. The BRT models were constructed to provide baseline support to stressor delineation by identifying natural physiographic and human land use gradients affecting stream biological condition statewide and for eight ecological regions within the state, as part of the development of numerical biological objectives for California’s wadeable streams. Regions were defined on the basis of ecological, hydrologic, and jurisdictional factors and roughly corresponded with ecoregions. Physiographic and land use variables were derived from geographic information system coverages. The model for the entire state (n = 1,386) identified a composite measure of anthropogenic disturbance (the sum of urban, agricultural, and unmanaged roadside vegetation land cover) within the local watershed as the most important variable, explaining 56 % of the variance in O/E values. Models for individual regions explained between 51 and 84 % of the variance in O/E values. Measures of human disturbance were important in the three coastal regions. In the South Coast and Coastal Chaparral, local watershed measures of urbanization were the most important variables related to biological condition, while in the North Coast the composite measure of human disturbance at the watershed scale was most important. In the two mountain regions, natural gradients were most important, including slope, precipitation, and temperature. The remaining three regions had relatively small sample sizes (n ≤ 75 sites) and had models that gave mixed results. Understanding the spatial scale at which land use and land cover affect

  9. Imaging large vessel vasculitis with fully integrated PET/MRI: a pilot study

    International Nuclear Information System (INIS)

    Einspieler, Ingo; Pyka, Thomas; Eiber, Matthias; Thuermel, Klaus; Wolfram, Sabine; Moog, Philipp; Reeps, Christian; Essler, Markus

    2015-01-01

    The aim of this study was to evaluate the feasibility of hybrid [ 18 F]fluorodeoxyglucose (FDG) positron emission tomography (PET)/MRI in patients with large vessel vasculitis (LVV) by comparing visual and quantitative parameters to that of PET/CT. Furthermore, the value of PET/MRI in disease activity and extent of LVV was assessed. A total of 16 [ 18 F]FDG PET/MRI and 12 [ 18 F]-FDG PET/CT examinations were performed in 12 patients with LVV. MRI of the vessel wall by T1-weighted and T2-weighted sequences was used for anatomical localization of FDG uptake and identification of morphological changes associated with LVV. In addition, contrast-enhanced (CE) magnetic resonance angiography (MRA) was performed. The vascular FDG uptake in the vasculitis group was compared to a reference group of 16 patients using a four-point visual score. Visual scores and quantitative parameters [maximum standardized uptake value (SUV max ) and target to background ratio (TBR)] were compared between PET/MRI and PET/CT. Furthermore, correlations between C-reactive protein (CRP) and quantitative PET results, as well the extent of vasculitis in PET, MRI/CE-MRA and combined PET/MRI, were analysed. TBRs, SUV max values and visual scores correlated well between PET/MRI and PET/CT (r = 0.92, r = 0.91; r = 0.84, p < 0.05). There was no significant difference between both modalities concerning SUV max measurements and visual scores. In PET/MRI, PET alone revealed abnormal FDG uptake in 86 vascular regions. MRI/CE-MRA indicated 49 vessel segments with morphological changes related to vasculitis, leading to a total number of 95 vasculitis regions in combination with PET. Strong and significant correlations between CRP and disease extent in PET alone (r = 0.75, p = 0.0067) and PET/MRI (r = 0.92, p < 0.0001) in contrast to MRI/CE-MRA only were observed. Regarding disease activity, no significant correlations were seen between quantitative PET results and CRP, although there was a trend towards

  10. Imaging large vessel vasculitis with fully integrated PET/MRI: a pilot study

    Energy Technology Data Exchange (ETDEWEB)

    Einspieler, Ingo; Pyka, Thomas; Eiber, Matthias [Technische Universitaet Muenchen, Klinikum rechts der Isar, Department of Nuclear Medicine, Munich (Germany); Thuermel, Klaus; Wolfram, Sabine; Moog, Philipp [Technische Universitaet Muenchen, Klinikum rechts der Isar, Department of Nephrology, Munich (Germany); Reeps, Christian [Technische Universitaet Muenchen, Department of Vascular Surgery, Klinikum rechts der Isar, Munich (Germany); Essler, Markus [Rheinische Friedrich-Wilhelms-Universitaet, Department of Nuclear Medicine, Universitaetsklinikum Bonn, Bonn (Germany)

    2015-04-16

    The aim of this study was to evaluate the feasibility of hybrid [{sup 18}F]fluorodeoxyglucose (FDG) positron emission tomography (PET)/MRI in patients with large vessel vasculitis (LVV) by comparing visual and quantitative parameters to that of PET/CT. Furthermore, the value of PET/MRI in disease activity and extent of LVV was assessed. A total of 16 [{sup 18}F]FDG PET/MRI and 12 [{sup 18}F]-FDG PET/CT examinations were performed in 12 patients with LVV. MRI of the vessel wall by T1-weighted and T2-weighted sequences was used for anatomical localization of FDG uptake and identification of morphological changes associated with LVV. In addition, contrast-enhanced (CE) magnetic resonance angiography (MRA) was performed. The vascular FDG uptake in the vasculitis group was compared to a reference group of 16 patients using a four-point visual score. Visual scores and quantitative parameters [maximum standardized uptake value (SUV{sub max}) and target to background ratio (TBR)] were compared between PET/MRI and PET/CT. Furthermore, correlations between C-reactive protein (CRP) and quantitative PET results, as well the extent of vasculitis in PET, MRI/CE-MRA and combined PET/MRI, were analysed. TBRs, SUV{sub max} values and visual scores correlated well between PET/MRI and PET/CT (r = 0.92, r = 0.91; r = 0.84, p < 0.05). There was no significant difference between both modalities concerning SUV{sub max} measurements and visual scores. In PET/MRI, PET alone revealed abnormal FDG uptake in 86 vascular regions. MRI/CE-MRA indicated 49 vessel segments with morphological changes related to vasculitis, leading to a total number of 95 vasculitis regions in combination with PET. Strong and significant correlations between CRP and disease extent in PET alone (r = 0.75, p = 0.0067) and PET/MRI (r = 0.92, p < 0.0001) in contrast to MRI/CE-MRA only were observed. Regarding disease activity, no significant correlations were seen between quantitative PET results and CRP, although there

  11. Methods for large-scale international studies on ICT in education

    NARCIS (Netherlands)

    Pelgrum, W.J.; Plomp, T.; Voogt, Joke; Knezek, G.A.

    2008-01-01

    International comparative assessment is a research method applied for describing and analyzing educational processes and outcomes. They are used to ‘describe the status quo’ in educational systems from an international comparative perspective. This chapter reviews different large scale international

  12. Study of Large Data Resources for Multilingual Training and System Porting (Pub Version, Open Access)

    Science.gov (United States)

    2016-05-03

    extraction trained on a large database corpus – English Fisher. Although the performance of ported monolingual system would be worse in comparison...Language TE LI HA LA ZU LLP hours 8.6 9.6 7.9 8.1 8.4 LM sentences 11935 10743 9861 11577 10644 LM words 68175 83157 93131 93328 60832 dictionary 14505

  13. Relationship between homocysteine and coronary artery disease. Results from a large prospective cohort study

    NARCIS (Netherlands)

    Schaffer, A.; Verdoia, M.; Cassetti, E.; Marino, P.; Suryapranata, H.; Luca, G. De

    2014-01-01

    BACKGROUND: Coronary artery disease (CAD) still represents the major cause of mortality in developed countries. Large research programs have been focused on the identification of new risk factors to prevent CAD, with special attention to homocysteine (Hcy), due to the known associated increased

  14. A computational study of ethylene–air sooting flames: Effects of large polycyclic aromatic hydrocarbons

    KAUST Repository

    Selvaraj, Prabhu; Arias, Paul G.; Lee, Bok Jik; Im, Hong G.; Wang, Yu; Gao, Yang; Park, Sungwoo; Sarathy, Mani; Lu, Tianfeng; Chung, Suk-Ho

    2015-01-01

    formation to various chemical pathways for large polycyclic aromatic hydrocarbons (PAH). The gas-phase chemical mechanism adopted the KAUST-Aramco PAH Mech 1.0, which utilized the AramcoMech 1.3 for gas-phase reactions validated for up to C2 fuels

  15. Large scale electronic structure calculations in the study of the condensed phase

    NARCIS (Netherlands)

    van Dam, H.J.J.; Guest, M.F.; Sherwood, P.; Thomas, J.M.H.; van Lenthe, J.H.; van Lingen, J.N.J.; Bailey, C.L.; Bush, I.J.

    2006-01-01

    We consider the role that large-scale electronic structure computations can now play in the modelling of the condensed phase. To structure our analysis, we consider four distict ways in which today's scientific targets can be re-scoped to take advantage of advances in computing resources: 1. time to

  16. Total synthesis and related studies of large, strained, and bioactive natural products

    Science.gov (United States)

    HIRAMA, Masahiro

    2016-01-01

    Our chemical syntheses and related scientific investigations of natural products with complex architectures and powerful biological activities are described, focusing on the very large 3 nm-long polycyclic ethers called the ciguatoxins, highly strained and labile chromoprotein antitumor antibiotics featuring nine-membered enediyne cores, and extremely potent anthelmintic macrolides called the avermectins. PMID:27725470

  17. Study of factorization in QCD with polarized beams and a production at large psub(T)

    International Nuclear Information System (INIS)

    Craigie, N.S.; Baldracchini, F.; Roberto, V.; Socolovsky, M.

    1980-07-01

    We discuss what aspects of the leading orders in QCD could be tested in the large psub(T) reactions p-bar-vectorp → Λ-vector + X, p-barp-vector → Λ-vector + X and p-bar-vectorp-vector → Λ + X. (author)

  18. Upscaling Large Scale Deep Renovation in the Dutch Residential Sector : A Case Study

    NARCIS (Netherlands)

    van Oorschot, John; Hofman, Erwin; Halman, Johannes I.M.

    2016-01-01

    The 2014 carbon emission of the Dutch economy was estimated at 194.4 billion kg. Dutch households are responsible for a particular large part of the total emission, about 37.1 billion kg or 19% of the total emission in 2014. While society becomes aware of the negative side effects of carbon emission

  19. A method to study response of large trees to different amounts of available soil water

    Science.gov (United States)

    D.H. Marx; Shi-Jean S. Sung; J.S. Cunningham; M.D. Thompson; L.M. White

    1995-01-01

    A method was developed to manipulate available soil water on large trees by intercepting thrufall with gutters placed under tree canopies and irrigating the intercepted thrufall onto other trees. With this design, trees were exposed for 2 years to either 25% less thrufall, normal thrufall, or 25% additional thrufall.Undercanopy construction in these plots moderately...

  20. Life as an emergent phenomenon: studies from a large-scale boid simulation and web data

    Science.gov (United States)

    Ikegami, Takashi; Mototake, Yoh-ichi; Kobori, Shintaro; Oka, Mizuki; Hashimoto, Yasuhiro

    2017-11-01

    A large group with a special structure can become the mother of emergence. We discuss this hypothesis in relation to large-scale boid simulations and web data. In the boid swarm simulations, the nucleation, organization and collapse dynamics were found to be more diverse in larger flocks than in smaller flocks. In the second analysis, large web data, consisting of shared photos with descriptive tags, tended to group together users with similar tendencies, allowing the network to develop a core-periphery structure. We show that the generation rate of novel tags and their usage frequencies are high in the higher-order cliques. In this case, novelty is not considered to arise randomly; rather, it is generated as a result of a large and structured network. We contextualize these results in terms of adjacent possible theory and as a new way to understand collective intelligence. We argue that excessive information and material flow can become a source of innovation. This article is part of the themed issue 'Reconceptualizing the origins of life'.