WorldWideScience

Sample records for large complex odontoma

  1. Large erupting complex odontoma: a case report.

    Science.gov (United States)

    Vengal, Manoj; Arora, Honey; Ghosh, Sujoy; Pai, Keerthilatha M

    2007-03-01

    Odontomas are the most common odontogenic tumours. They are usually asymptomatic and are often discovered during routine radiography. We report a case of a large erupting complex odontoma that caused pain, infection and facial asymmetry. This case is significant as there are few reports of complex odontoma erupting in the oral cavity.

  2. Complex odontoma.

    Science.gov (United States)

    Preetha, A; Balikai, Bharati S; Sujatha, D; Pai, Anuradha; Ganapathy, K S

    2010-01-01

    Odontomas are hamartomatous lesions or malformations composed of mature enamel, dentin, and pulp. They may be compound or complex, depending on the extent of morphodifferentiation or their resemblance to normal teeth. The etiology of odontoma is unknown, although several theories have been proposed. This article describes a case of a large infected complex odontoma in the residual mandibular ridge, resulting in considerable mandibular expansion.

  3. Unusually large erupted complex odontoma: A rare case report

    Energy Technology Data Exchange (ETDEWEB)

    Bagewadi, Shivanand B.; Kukreja, Rahul; Suma, Gundareddy N.; Yadav, Bhawn; Sharma, Havi [Dept. of Oral Medicine and Radiology, ITS Centre for Dental Studies and Research, Murad Nagar (India)

    2015-03-15

    Odontomas are nonaggressive, hamartomatous developmental malformations composed of mature tooth substances and may be compound or complex depending on the extent of morphodifferentiation or on their resemblance to normal teeth. Among them, complex odontomas are relatively rare tumors. They are usually asymptomatic in nature. Occasionally, these tumors become large, causing bone expansion followed by facial asymmetry. Odontoma eruptions are uncommon, and thus far, very few cases of erupted complex odontomas have been reported in the literature. Here, we report the case of an unusually large, painless, complex odontoma located in the right posterior mandible.

  4. Unusually large erupted complex odontoma: A rare case report.

    Science.gov (United States)

    Bagewadi, Shivanand B; Kukreja, Rahul; Suma, Gundareddy N; Yadav, Bhawna; Sharma, Havi

    2015-03-01

    Odontomas are nonaggressive, hamartomatous developmental malformations composed of mature tooth substances and may be compound or complex depending on the extent of morphodifferentiation or on their resemblance to normal teeth. Among them, complex odontomas are relatively rare tumors. They are usually asymptomatic in nature. Occasionally, these tumors become large, causing bone expansion followed by facial asymmetry. Odontoma eruptions are uncommon, and thus far, very few cases of erupted complex odontomas have been reported in the literature. Here, we report the case of an unusually large, painless, complex odontoma located in the right posterior mandible.

  5. Surgical Treatment of a Large Complex Odontoma

    Directory of Open Access Journals (Sweden)

    Burak Cezairli

    2017-08-01

    Full Text Available The treatment modalities for odontomas are generally depend on the tumors size. Small and medium lesions can usually be removed easily allowing preservation of surrounding anatomical structures. In our study, we reported a conservative surgical treatment of a large complex odontoma. A 19-year-old woman was referred to our clinic after an incidentally observed lesion on her right mandibular angle. The patient was symptom-free at the time of visit. Computed tomography (CT images showed a mass with a size of 3.5 cm x 3 cm x 2 cm. CT sections and tridimensional images showed partially eroded buccal and lingual cortex. Surgical treatment was indicated with an initial diagnosis of compound odontoma. The lesion removed after sectioning with bur and maxillo-mandibular fixation (MMF were not thought to be necessary while the buccal and lingual cortexes were mostly reliable for preventing a fracture. In our case, the size of the odontoma was suitable for a conservative treatment method and with this modality we managed to prevent a possible fracture and eliminate the disadvantages of MMF.

  6. Management of Large Erupting Complex Odontoma in Maxilla

    Directory of Open Access Journals (Sweden)

    Colm Murphy

    2014-01-01

    Full Text Available We present the unusual case of a large complex odontoma erupting in the maxilla. Odontomas are benign developmental tumours of odontogenic origin. They are characterized by slow growth and nonaggressive behaviour. Complex odontomas, which erupt, are rare. They are usually asymptomatic and are identified on routine radiograph but may present with erosion into the oral cavity with subsequent cellulitis and facial asymmetry. This present paper describes the presentation and management of an erupting complex odontoma, occupying the maxillary sinus with extension to the infraorbital rim. We also discuss various surgical approaches used to access this anatomic area.

  7. Large Complex Odontoma of Mandible in a Young Boy: A Rare and Unusual Case Report

    Directory of Open Access Journals (Sweden)

    G. Siva Prasad Reddy

    2014-01-01

    Full Text Available Odontomas are the most common odontogenic tumors. They are broadly classified in to Compound Odontoma and Complex Odontoma. Among them complex odontoma is a rare tumor. Occasionally this tumor becomes large, causing expansion of bone followed by facial asymmetry. Otherwise these tumors are asymptomatic and are generally diagnosed on radiographic examination. We report a rare case of complex odontoma of mandible in a young boy. The tumor was treated by surgical excision under general anesthesia.

  8. Large complex odontoma of mandible in a young boy: a rare and unusual case report.

    Science.gov (United States)

    Reddy, G Siva Prasad; Reddy, G V; Sidhartha, B; Sriharsha, K; Koshy, John; Sultana, Rehana

    2014-01-01

    Odontomas are the most common odontogenic tumors. They are broadly classified in to Compound Odontoma and Complex Odontoma. Among them complex odontoma is a rare tumor. Occasionally this tumor becomes large, causing expansion of bone followed by facial asymmetry. Otherwise these tumors are asymptomatic and are generally diagnosed on radiographic examination. We report a rare case of complex odontoma of mandible in a young boy. The tumor was treated by surgical excision under general anesthesia.

  9. An erupted complex odontoma.

    Science.gov (United States)

    Tozoglu, Sinan; Yildirim, Umran; Buyukkurt, M Cemil

    2010-01-01

    Odontomas are benign tumors of odontogenic origin. The cause of the odontoma is unknown, but it is believed to be hereditary or due to a disturbance in tooth development triggered by trauma or infection. Odontomas may be either compound or complex. Although these tumors are seen frequently, erupted odontomas are rare. The purpose of this study is to present a rare case of complex odontoma that erupted into the oral cavity.

  10. Unusually large complex odontoma in maxillary sinus associated with unerupted tooth. Report of case and review of literature.

    Science.gov (United States)

    Singer, Steven R; Mupparapu, Muralidhar; Milles, Maano; Rinaggio, Joseph; Pisano, Dominic; Quaranta, Patrick

    2007-01-01

    An unusual case of a large complex odontoma with an associated impacted tooth is presented. Odontomas are hamartomatous growths of enamel, dentin, cementum and pulp tissue. Although they are usually tooth-sized or smaller, occasionally, the complex variant can exhibit considerable growth, as was seen in the case presented here. It occupied most of the maxillary sinus and displaced the floor of the orbit and the medial and posterior walls of the left maxillary sinus. Panoramic radiographs, as well as axial and coronal CT studies, showed the extent of the lesion in various dimensions. A differential diagnosis of various calcifying tumors was formulated on the basis of these findings. The lesion was surgically excised, and histologic analysis confirmed the radiographic impression. Although odontomas of this magnitude are rare, this case demonstrates the value of imaging, radiographic histopathologic diagnosis and surgical treatment planning prior to any definitive treatment.

  11. Maxillary reconstruction with particulate bone graft and titanium mesh: a treatment option for large complex odontoma of the maxilla.

    Science.gov (United States)

    Utumi, Estevam Rubens; Cremonini, Caio Cesar; Pedron, Irineu Gregnanin; Zambon, Camila Eduarda; Cavalcanti, Marcelo Gusmão Paraíso; Ceccheti, Marcelo Minharro

    2011-07-01

    Odontomas are the most common type of odontogenic tumor and are generally asymptomatic. The purpose of this paper was to describe the case of a complex odontoma in a patient who had asymptomatic swelling in the central maxillary region, along with unerupted central and lateral incisors. In this case, surgical excision of the lesion was performed and an iliac bone graft was introduced into the defect area with a titanium mesh covering up the grafted harvesting bone. After 2 years of followup, no recurrence was identified. Patient followup is still in progress to evaluate bone graft resorption, and the patient awaits complete bone development. Oral rehabilitation with an osseointegrated titanium implant is expected in the future. An option of the large complex odontoma treatment is discussed.

  12. Surgical management of a large complex odontoma of the mandibular angle-ramus region through intra-oral buccal approach--A case report.

    Science.gov (United States)

    Ogunlewe, M O; Adeyemo, W L; Ladeinde, A L; Bamgbose, B O; Ajayi, O F

    2005-12-01

    Large complex odontomas of the jaws are rare. A report of a large complex odontoma of the mandibular angle-ramus region enucleated through intra-oral buccal approach is presented. A review of the literature on different modalities of treatment is also undertaken. A large expansile complex odontoma of the angle-ramus region of the mandible was excised through an intraoral buccal approach under general anaesthesia. Recovery and immediate post-operative period were uneventful. There was no altered sensation in the distribution of the inferior alveolar nerve and lingual nerve; and wound healing was satisfactory. Post-operative radiograph 2 years after the operation showed satisfactory bone regeneration. Intraoral buccal approach to large complex odontomas of the angle-ramus region of the mandible is a relatively safe procedure with minimal complication.

  13. Infected complex odontoma: an unusual presentation.

    Science.gov (United States)

    Agrawal, Bhavana; Gharote, Harshkant; Nair, Preeti; Shrivastav, Saurabh

    2012-08-24

    Odontomas represent a hamartomatous malformation. They are usually asymptomatic and are diagnosed on routine radiological examination .The eruption and infection of odontoma are uncommon. Till now, only 20 cases of erupted odontoma are reported in the literature. We report an unusual case of infected complex odontoma with eruption of odontoma in the oral cavity and perforation of the cheeks with a tooth impacted upon which makes the presentation unusual that has not been reported earlier. The dentist should be familiar with common and unusual appearance of odontoma for proper diagnosis and management.

  14. Large erupting complex odontoma in a dentigerous cyst removed by a piecemeal resection.

    Science.gov (United States)

    Biocic, Josip; Macan, Darko; Brajdic, Davor; Manojlovic, Spomenka; Butorac-Rakvin, Lidija; Hat, Josip

    2010-01-01

    Odontomas (ODs) are the most frequent odontogenic tumors in Western societies, they are often asymptomatic and discovered during routine radiography The purpose of this report was to describe the case of a 10-year-old child with an odontoma within a dentigerous cyst (DC). The patient presented with a 1-week history of painful swelling involving the right mandible and cheek. An intraoral examination revealed a defect of the oral mucosa behind the permanent mandibular first molar, which resembled an exposed alveolar bone or tooth remnants. Clinical and radiographic evaluation revealed a large erupting OD associated with a dentigerous cyst. The OD was separated into pieces and enucleated together with the dentigerous cyst to preserve the mandible's integrity and because of the patient's age. This is the first report of an erupting OD associated with a DC in a child. Surgical removal might be a challenge when large ODs are encountered.

  15. Infected Complex Odontoma: A Case Report

    OpenAIRE

    Damodar, Shanthala; Veena KM; Chatra, Laxmikanth; Shenai, Prashanth; Rao, Prasanna Kumar; Prabhu, Rachana V.; Kushraj, Tashika; Shetty, Prathima; Hameed, Shaul

    2015-01-01

    Odontoma represent a hamartomatous malformation. They are usually asymptomatic and are diagnosed on routine radiological examination. Infection of an odontome is very uncommon. Few cases of infected odontoma are reported in the literature. We report a special case of infected complex odontoma and perforation of the cheeks with a tooth impacted upon along with computed tomographic (CT) image. Thus, making the present case unusual.

  16. [Complex odontoma with dentigerous cyst: a case report].

    Science.gov (United States)

    Qizhang, Xu; Hongliang, Zhang; Xiaoyu, Wang; Zhanji, Wang; Qianqian, Xu; Qiong, Ma

    2014-12-01

    Complex odontoma is a relatively rare dental dysplasia. In particular, a complex odontoma with dentigerous cyst is seldom observed. A case of complex odontoma with dentigerous cyst is reported in this paper.

  17. Complex Composite Odontoma with Characteristic Histology

    Directory of Open Access Journals (Sweden)

    Sujatha Govindrajan

    2013-01-01

    Full Text Available Odontomas are the most commonly occurring odontogenic tumors, which are considered by many to be hamartomas rather than neoplasms. These clinically asymptomatic tumors are classified into complex and compound odontomas. They are usually discovered in radiographs and rarely cause bony expansion or infection. This paper discusses a case report of a complex odontoma exhibiting all the structural features and defects of enamel, dentine, and cementum in succession, with an overview on its etiology.

  18. Giant complex odontoma in maxillary sinus.

    Science.gov (United States)

    Carvalho Visioli, Adriano Rossini; de Oliveira E Silva, Cléverson; Marson, Fabiano Carlos; Takeshita, Wilton Mitsunari

    2015-01-01

    In this manuscript, we present a rare case report of giant complex odontoma in the maxillary sinus, where the applied therapy included complete excision of the lesion with a conservative approach. Odontomas are also called benign growth abnormalities or hamartomas. They represent a more common type of odontogenic tumor and are related to various disorders such as bad dental placements, expansion, increased volumetric bone, and no eruption of permanent teeth. Usually they have an asymptomatic evolutionary course. The etiologic factors, although obscure, are related to local trauma, infection, and genetic factor. The structural composition of an odontoma consists of mature dental tissues. Odontomas can be differentiated according to their anatomical presentations: Compound odontoma-clusters of several denticles and complex odontoma-well defined tumefaction mass. The diagnosis can be performed by radiographic examination.

  19. Infected Complex Odontoma: A Case Report

    Directory of Open Access Journals (Sweden)

    Shanthala Damodar

    2015-06-01

    Full Text Available Odontoma represent a hamartomatous malformation. They are usually asymptomatic and are diagnosed on routine radiological examination. Infection of an odontome is very uncommon. Few cases of infected odontoma are reported in the literature. We report a special case of infected complex odontoma and perforation of the cheeks with a tooth impacted upon along with computed tomographic (CT image. Thus, making the present case unusual. [Cukurova Med J 2015; 40(2.000: 379-383

  20. Histopathological insight of complex odontoma associated with a dentigerous cyst.

    Science.gov (United States)

    Astekar, Madhusudan; Manjunatha, Bhari Sharanesha; Kaur, Prabhpreet; Singh, Jappreet

    2014-01-31

    Odontomas and dentigerous cysts are common findings for practicing dental professionals. However, simultaneous occurrence of pathologies like odontoma and dentigerous cyst are uncommon and their diagnosis based on the radiographic appearance alone is a challenge to overcome. They together are a potential for complications like attaining large size, root resorption, destruction of the jaw bones and sometimes neoplastic changes like ameloblastoma. This paper presents a case of complex odontoma associated with dentigerous cyst in relation to a retained deciduous tooth in the maxillary anterior region and confirming its diagnosis histopathologically.

  1. Complex Odontoma: Early Detection, Immediate Correction

    Directory of Open Access Journals (Sweden)

    Ashwini Rani

    2014-07-01

    Full Text Available Odontomas are the most common odontogenic tumours of the jaws, which are benign, slow growing and nonaggressive. Odontomas are usually asymptomatic, but sometimes may interfere with the eruption of the associated teeth leading to impaction or delayed eruption and displacement of adjacent teeth resulting in malocclusion. This article presents a case of complex odontoma in a 12-year-old male patient, who reported with a complaint of delayed eruption of permanent left maxillary first and second molars. The radiological features revealed impacted first, second and third molars with a radiolucent capsule and a corticated border suggestive of Odontoma. A treatment of surgical excision of the lesion, followed by orthodontic traction of unerupted maxillary left first and second molars was carried out successfully. The patient was followed for two years with no recurrence of the lesion.

  2. Sequestrating giant complex odontoma: a case report and review of the literature.

    Science.gov (United States)

    Perumal, C J; Mohamed, A; Singh, A; Noffke, C E E

    2013-12-01

    Odontomas are the most common benign tumours of odontogenic origin. Due to their hamartomatous nature, they are usually asymptomatic but can cause impaction of one or more teeth. They consist microscopically of all the tissue types found in a developed tooth. We present a case of a large sequestrating complex odontoma resulting in facial asymmetry, cellulitis, pain and partial loss of function. This case has significance, as odontomas of this large size have rarely been reported.

  3. A Large Ameloblastic Fibro-odontoma of the Maxillary Sinus

    Directory of Open Access Journals (Sweden)

    Seyed Ali Banihashem Rad

    2014-04-01

    Full Text Available Introduction: Ameloblastic fibro-odontoma is a rare, benign, asymptomatic tumor. The term ameloblastic fibro-odontoma was first used by Hooker in 1967 as a separate lesion from ameloblastic odontoma.   Case Report: This case report describes an eleven years old female with large ameloblastic fibro-odontoma in the right maxillary sinus.   Conclusion: There is a low potential for recurrence after complete Enucleation of ameloblastic fibro-odontoma, but due to the risk of ameloblastic sarcoma after recurrence, the surgery should be perfect along with a careful follow up. 

  4. Erupted complex composite odontoma: Report of two atypical cases

    Directory of Open Access Journals (Sweden)

    Preeti Tomar Bhattacharya

    2015-01-01

    Full Text Available Odontomas are nonaggressive, hamartomatous developmental malformations of odontogenic origin. They are considered one of the most common odontogenic lesions composed by diverse dental tissues. They may interfere with the eruption of an associated tooth and are more prevalent in the posterior mandible. The eruption of a complex odontoma into the oral cavity is rare. Here, we report such two rare cases of gigantic erupted complex composite odontomas.

  5. Review of 61 cases of odontoma. Presentation of an erupted complex odontoma.

    Science.gov (United States)

    Amado Cuesta, Susana; Gargallo Albiol, Jordi; Berini Aytés, Leonardo; Gay Escoda, Cosme

    2003-01-01

    Odontomas are benign tumors of odontogenic origin characterized by their slow growth. They consist of enamel, dentine, cementum and pulpal tissue and constitute 22% of all odontogenic tumors. Two types of odontoma are recognized: compound and complex. The first is approximately twice as common as complex odontomas. The purpose of this study is to value the prevalence of this kind of tumors in the ambulatory-surgical gambit and their clinical symptoms. We want to emphasize the exceptional spontaneous eruption of this tumors and we report a case of erupted complex odontoma. We made the revision of the cases of diagnosed odontomas between 1983 and 2001 in the Clínica Ntra. Sra. del Remei, in the Centro Médico Teknon and the Master de Cirugía e Implantología Bucal of the Odontologic Clínic (Barcelona University). We analyzed their prevalence, distribution in gender, age of the patients, anatomic location, adjacent structures affectation, symptoms, histologic classification and treatment. 52.4% of the cases were diagnosed in females. 37.7% of the tumors were complex odontomas and 62.3% were diagnosed as compound odontomas. 55.7% of all cases were in the maxilla and 44.3% in the mandible. The anterior portion of maxilla was the most common location (54% of cases). Only a case (1.6%) was erupted, in the molars area of the maxilla.

  6. Peripheral ameloblastic fibro-odontoma or peripheral developing complex odontoma: report of a case

    DEFF Research Database (Denmark)

    Reibel, Jesper; Grønbæk, Anni Birgitte; Poulsen, Sven

    2011-01-01

    BACKGROUND. Peripheral (extraosseous) odontogenic tumors are rare. CASE REPORT. This report describes a case which illustrates the clinical and histopathological features of a lesion in an 8-year-old, healthy Caucasian girl that on purely morphological grounds would seem to be an ameloblastic fibro-odontoma......, but may represent a case of a peripheral developing complex odontoma. CONCLUSION. Conservative surgical enucleation of the lesion was followed by unbcomplicated healing and no recurrence was seen....

  7. Peripheral ameloblastic fibro-odontoma or peripheral developing complex odontoma: report of a case.

    Science.gov (United States)

    Reibel, Jesper; Grønbaek, Anni B; Poulsen, Sven

    2011-11-01

    BACKGROUND. Peripheral (extraosseous) odontogenic tumors are rare. CASE REPORT. This report describes a case which illustrates the clinical and histopathological features of a lesion in an 8-year-old, healthy Caucasian girl that on purely morphological grounds would seem to be an ameloblastic fibro-odontoma, but may represent a case of a peripheral developing complex odontoma. CONCLUSION. Conservative surgical enucleation of the lesion was followed by unbcomplicated healing and no recurrence was seen.

  8. Complex odontoma associated to a primary maxillary canine: case report

    Directory of Open Access Journals (Sweden)

    Estela Maris LOSSO

    2009-06-01

    Full Text Available Introduction: Odontomas are malformations of the dental tissues and may interfere with the eruption of the associated tooth. The early diagnosis, followed by a proper treatment at the right time, will result in a favorable prognosis and a desirable occlusion development. Complex odontomas associated to primary teeth are rare. Case report and conclusion: This article describes a case of a complex odontoma in a four-year-old girl that prevented eruption of the left primary canine. The treatment choice was enucleation of the odontoma and the maintenance of the left primary canine.In this case, complete removal of the complex odontoma was successfully conducted, since after one year of follow-up the primary maxillary canine restarted its eruption process.

  9. Erupted complex odontoma: a case report and literature review.

    Science.gov (United States)

    Litonjua, Luis A; Suresh, Lakshmanan; Valderrama, Lucia S; Neiders, Mirdza E

    2004-01-01

    A case involving a 17-year-old girl with a large erupted odontoma associated with a deeply impacted mandibular molar is reported. The molar, which previously had been displaced to the border of the mandible, erupted successfully three years after surgical removal of the odontoma. A review of the literature presents guidelines for treating similar cases.

  10. Complex odontoma of unusual size involving the maxillary sinus: report of a case and review of CT and histopathologic features.

    Science.gov (United States)

    Mupparapu, Muralidhar; Singer, Steven R; Rinaggio, Joseph

    2004-09-01

    An unusually large complex odontoma of the maxilla, occupying the entire maxillary sinus with expansion into the floor of the orbit and left nasal fossa, is reported. Although occurrences of complex odontomas are not considered rare, odontomas attaining extremely large sizes, especially involving the entire maxillary sinus with extension to the orbital floor and nasal fossae, are indeed, rare. In this article, the literature is reviewed to identify the common clinical, radiographic, and histologic characteristics of such lesions, and the outcome of treatment is discussed. Complex odontomas occasionally have significant growth potential, especially in the first two decades of life. Early recognition and consideration for surgical excision are key to successful management of this common odontogenic lesion. When odontomas extend beyond the alveolar process into the fascial planes, nasal fossae, paranasal sinuses, and orbits, computed tomography can readily demonstrate the extent and boundaries of the lesion.

  11. Dentigerous cyst associated with multiple complex composite odontomas

    Directory of Open Access Journals (Sweden)

    Sangeeta P Wanjari

    2011-01-01

    Full Text Available Odontomas are considered to be hamartomatous malformations rather than true neoplasms. This most common odontogenic lesion results from the growth of completely differentiated epithelial and mesenchymal cells that give rise to ameloblasts and odontoblasts. Dentigerous cyst is an epithelium-lined sac enclosing the crown of an unerupted tooth. Apparently, the dentigerous cyst arises by the accumulation of fluid between reduced enamel epithelium and the tooth crown. Occasionally it is associated with supernumerary tooth or odontoma. We report a case of dentigerous cyst associated with complex composite odontoma and an impacted lateral incisor in a 30-year-old male patient.

  12. Erupted complex odontoma of the posterior maxilla: A rarity.

    Science.gov (United States)

    Verma, Sonika; Arul, A Sri Kennath J; Arul, A Sri Sennath J; Chitra, S

    2015-08-01

    Complex odontomas, hamartomas of aborted tooth development, mainly occur in posterior part of the mandible and rarely erupt into the oral cavity. The spontaneous eruption may be associated with pain, inflammation of adjacent soft tissues or recurrent infection. The present case of complex odontoma is of particular interest due to its apparent eruption in the maxillary posterior segment, its association with agenesis of the second molar and impacted third molar; with the lesion being completely asymptomatic.

  13. Complex odontoma of the nasal cavity: a case report.

    Science.gov (United States)

    Soltan, Michelle; Kacker, Ashutosh

    2008-05-01

    We describe the case of a 76-year-old man who presented with symptoms of chronic nasal obstruction and recurrent sinusitis of many years' duration. The patient's history and radiographic findings established a diagnosis of a complex odontoma of the nasal cavity. The mass was surgically excised, and the diagnosis was confirmed by histopathology. The occurrence of an odontoma in the nasal cavity is extremely rare.

  14. An Unusual Erupted Complex Composite Odontoma: A Rare Case

    Directory of Open Access Journals (Sweden)

    Dawasaz Ali Azhar

    2013-01-01

    Full Text Available Odontomas are malformations of the dental tissues and may interfere with the eruption of the associated tooth. Complex composite odontoma (CO was described as a distinct entity for the first time by Broca in 1866. This lesion takes place due to the developmental disturbances where the dental components are laid down in a disorganized manner, due to failure of normal morphodifferentiation. Very few cases of erupted complex composite odontomas have been reported in the literature. The case reported here is of an odontoma found in the left mandibular body, associated with an impacted second molar of a 17-year-old Saudi male. Under local anesthesia the odontoma was surgically removed. Histopathological examination confirmed the diagnosis of CO. The impacted second molar which was left in the mandibular body erupted clinically after 6 months. Erupted CO is rarely seen in the mandibular left body. The early diagnosis, followed by a proper treatment at the right time, will result in a favorable prognosis.

  15. Spontaneous complex odontoma in a Sprague-Dawley rat.

    Science.gov (United States)

    Jang, Dong Deuk; Kim, Chuel-Kyu; Ahn, Byeongwoo; Kang, Jin Seok; Nam, Ki Tack; Kim, Dae Joong; Han, Dong Un; Jung, Kwonil; Chung, Han-Kook; Ha, Seung-Kwon; Choi, Changsun; Cho, Wan-Seob; Kim, Junghyun; Chae, Chanhee

    2002-03-01

    Complex odontoma from a female Sprague-Dawley rat is described histopathologically. Necropsy revealed a hard (bony), white mass (3.0 x 3.0 x 2.1 cm) on the left mandible. Microscopically, the mass consisted of islands or nests of epithelial and mesenchymal elements that formed abortive tooth structures. In other areas, tooth formation consisted of a pulp cavity lined by layers of odontoblasts, dentin, enamel, and ameloblasts. Concerning all features of normal tooth formation which was differentiated and mineralized yet completely disorganized, the diagnosis of complex odontoma was recommended.

  16. Compound composite odontoma.

    Science.gov (United States)

    Girish, G; Bavle, Radhika M; Singh, Manish Kumar; Prasad, Sahana N

    2016-01-01

    The term odontoma has been used as a descriptor for any tumor of odontogenic origin. It is a growth in which both epithelial and mesenchymal cells exhibits complete differentiation. Odontomas are considered as hamartomas rather than true neoplasm. They are usually discovered on routine radiographic examination. Odontomas, according to the World Health Organization, are classified into complex odontoma and compound odontomas. The present paper reports a case of compound composite odontomas.

  17. Compound composite odontoma

    Directory of Open Access Journals (Sweden)

    G Girish

    2016-01-01

    Full Text Available The term odontoma has been used as a descriptor for any tumor of odontogenic origin. It is a growth in which both epithelial and mesenchymal cells exhibits complete differentiation. Odontomas are considered as hamartomas rather than true neoplasm. They are usually discovered on routine radiographic examination. Odontomas, according to the World Health Organization, are classified into complex odontoma and compound odontomas. The present paper reports a case of compound composite odontomas.

  18. A complex odontoma of the anterior maxilla associated with an erupting canine.

    Science.gov (United States)

    Pillai, Ajay; Moghe, Swapnil; Gupta, Mithilesh K; Pathak, Abhishek

    2013-11-12

    Many developmental anomalies of the jaw are accidentally diagnosed during radiographic investigations for other symptoms. Complex odontomas are odontogenic tumours, relatively rare in the anterior maxilla and generally asymptomatic. Frequently the odontoma may interfere with the eruption of teeth. This paper describes a case of complex odontoma in an 8-year-old girl, which resulted in the palatal displacement of the lateral incisor and an erupting permanent canine. A calcified mass was seen on the radiograph and was provisionally diagnosed as an odontoma which was surgically enucleated. Routine follow-up was carried out for more than 1 year and no recurrence was seen.

  19. A large ameloblastic fibro-odontoma of the right mandible

    National Research Council Canada - National Science Library

    Oghli, Ayham Arab; Scuto, Ignazio; Ziegler, Christoph; Flechtenmacher, Christa; Hofele, Christof

    2007-01-01

    The ameloblastic fibro-odontoma is a rare mixed odontogenic tumor. It occurs predominantly in children and young adults with no sex predilection and locates most often in the posterior segment of the mandible...

  20. Bilateral coronoid hypoplasia and complex odontoma: a rare concurrence of developmental pathology and odontogenic tumour of the mandible.

    Science.gov (United States)

    Dar, Mohd Arif; Alaparthi, Ravikiran; Yalamanchili, Samatha; Santosh, Arvind Babu Rajendra

    2015-10-13

    We present a rare case of concurrent bilateral coronoid hypoplasia and complex odontoma in the mandible, with replacement of missing posterior teeth in both sides of the lower jaw. A 20-year-old woman was diagnosed with bilateral occurrence of coronoid hypoplasia and unerupted complex odontoma after radiographic and histopathological examination. The patient was surgically treated with complete removal of the unerupted complex odontoma and prosthetic replacement of the missing teeth.

  1. Giant complex odontoma of the anterior mandible: report of case with long follow up.

    Science.gov (United States)

    Spini, Pedro Henrique Rezende; Spini, Túlio Humberto; Servato, João Paulo Silva; Faria, Paulo Rogério de; Cardoso, Sérgio Vitorino; Loyola, Adriano Mota

    2012-01-01

    This paper describes an exceptional case of an enormous complex odontoma affecting the mandibular symphysis of a 9-year-old boy. Because of its dimensions, the lesion produced cortical bone expansion, dental displacement and impactation, which are clinical signs very seldom described for odontomas. The lesion was surgically excised in a conservative way using an intraoral approach with local anesthesia. After 7 years of follow up, all teeth had erupted and the mandibular bone healed totally. Because of its radiographic mixed radiolucent and radiopaque appearance and its expansive growth, it is imperative to make the differential diagnosis of giant complex odontoma for other more aggressive mixed odontogenic tumors, such as ameloblastic fibro-odontoma, odotoameloblastoma and cystic calcified odontogenic tumor. Conservative approach appears to be indicated in the treatment of such lesions.

  2. Surgical treatment of extensive complex odontoma in the mandible by corticotomy. A case report.

    Science.gov (United States)

    Nogueira, A S; Gonçales, E S; Gonçales, A G B; Thiegui-Neto, V; Nogueira, C B P; Nogueira, A; Medeiros, R

    2013-09-01

    Odontomas represent the most prevalent odontogenic tumors in the jaw. The treatment of choice is surgical removal, usually performed by conventional techniques involving ostectomies to expose the tumor. In this paper, the authors describe, through the report of a case of complex odontoma located in the mandibular angle, a more conservative surgical technique called corticotomy, in which the bone removed for access to the tumor (buccal cortical) is repositioned and fixed by titanium plates of 1.5 mm.

  3. A large ameloblastic fibro-odontoma of the right mandible.

    Science.gov (United States)

    Oghli, Ayham Arab; Scuto, Ignazio; Ziegler, Christoph; Flechtenmacher, Christa; Hofele, Christof

    2007-01-01

    The ameloblastic fibro-odontoma is a rare mixed odontogenic tumor. It occurs predominantly in children and young adults with no sex predilection and locates most often in the posterior segment of the mandible. A painless swelling is the most common clinical sign. Radiologically, ameloblastic fibro-odontoma shows a circumscribed radiolucency, which contains radio-opaque foci of various sizes and shapes. Histological examination reveals a fibrous soft tissue, islands of odontogenic epithelium and a disordered mixture of dental tissues. The tumor produces enamel or enamel matrix, dentin and cementum. The treatment of ameloblastic fibro-odontomas usually consists of enucleation or surgical curettage, which is possible due to their benign biological behaviour.

  4. The use of digital volume tomography in imaging an unusually large composite odontoma in the mandible.

    Science.gov (United States)

    Bhatavadekar, Neel B; Bouquot, Jerry E

    2009-01-01

    The odontoma is the most common of all odontogenic tumors. Digital volume tomography (DVT) provides a major advantage of decreased radiation and cost-effectiveness, as compared to a conventional computed tomography. There is no known published report utilizing this DVT analysis for assessing and localizing on odontomo. The purpose of this case report was to document the use of digital volume tomography to assess an unusually large composite odontoma in the mondible. Tomographic sections revealed expansion of the buccol cortex and occasional thinning of both the buccol and lingual cortical plates, although there was no pronounced clinically detectable cortical expansion. The sections further demonstrated enomel ond dentin in on irregular mass bearing no morphologic similority to rudimentary teeth. This case highlights the importance of early diagnosis and intervention for treating on odontoma while demonstrating the value of tomographic imaging as on aid to diagnosis.

  5. Orthokeratinizing odontogenic cyst of maxilla with complex odontoma

    Directory of Open Access Journals (Sweden)

    Meena Kulkarni

    2013-01-01

    Full Text Available The orthokeratinized odontogenic cyst (OOC and odontoma are the odontogenic cyst and tumor respectively that are minimally invasive neoplasms of head and neck region. OOC is a rare variant of odontogenic cyst characterized by the presence of excessive orthokeratin covering the cystic lining. Odontoma is a benign neoplasm/hamartoma often discovered accidently on panoramic radiographs. We came across a case of a 26‑year‑old male with swelling on his face along with difficulty in breathing. On the basis of radiographic and histopathological findings the final diagnosis of OOC associated with odontoma was given. However, there is no report in the English literature of the simultaneous occurrence of these two lesions and hence this case is very rare. It is unclear whether the two lesions were just coincidental or were actually related to each other.

  6. Orthokeratinizing odontogenic cyst of maxilla with complex odontoma.

    Science.gov (United States)

    Kulkarni, Meena; Kheur, Supriya; Agrawal, Tripti; Ingle, Yashwant

    2013-09-01

    The orthokeratinized odontogenic cyst (OOC) and odontoma are the odontogenic cyst and tumor respectively that are minimally invasive neoplasms of head and neck region. OOC is a rare variant of odontogenic cyst characterized by the presence of excessive orthokeratin covering the cystic lining. Odontoma is a benign neoplasm/hamartoma often discovered accidently on panoramic radiographs. We came across a case of a 26-year-old male with swelling on his face along with difficulty in breathing. On the basis of radiographic and histopathological findings the final diagnosis of OOC associated with odontoma was given. However, there is no report in the English literature of the simultaneous occurrence of these two lesions and hence this case is very rare. It is unclear whether the two lesions were just coincidental or were actually related to each other.

  7. Erupted complex odontoma delayed eruption of permanent molar.

    Science.gov (United States)

    Ohtawa, Yumi; Ichinohe, Saori; Kimura, Eri; Hashimoto, Sadamitsu

    2013-01-01

    Odontomas, benign tumors that develop in the jaw, rarely erupt into the oral cavity. We report an erupted odontoma which delayed eruption of the first molar. The patient was a 10-year-old Japanese girl who came to our hospital due to delayed eruption of the right maxillary first molar. All the deciduous teeth had been shed. The second premolar on the right side had erupted, but not the first molar. Slight inflammation of the alveolar mucosa around the first molar had exposed a tooth-like, hard tissue. Panoramic radiography revealed a radiopaque mass indicating a lesion approximately 1 cm in diameter. The border of the image was clear, and part of the mass was situated close to the occlusal surface of the first molar. The root of the maxillary right first molar was only half-developed. A clinical diagnosis of odontoma was made. The odontoma was subsequently extracted, allowing the crown of the first molar to erupt almost 5 months later. The dental germ of the permanent tooth had been displaced by the odontoma. However, after the odontoma had been extracted, the permanent tooth was still able to erupt spontaneously, as eruptive force still remained. When the eruption of a tooth is significantly delayed, we believe that it is necessary to examine the area radiographically. If there is any radiographic evidence of a physical obstruction that might delay eruption, that obstruction should be removed before any problems can arise. Regular dental checkups at schools might improve our ability to detect evidence of delayed eruption earlier.

  8. Ameloblastic fibroodontoma or complex odontoma: Two faces of the same coin.

    Science.gov (United States)

    Singh, Akhilesh Kumar; Kar, Indu Bhusan; Mishra, Niranjan; Sharma, Parikshit

    2016-01-01

    An ameloblastic fibroodontoma (AFO) is a rare odontogenic tumor of mixed dental tissue origin. It exhibits histological features of ameloblastic fibroma and complex odontoma. AFOs are usually found to be asymptomatic and are most often discovered on routine radiography. Sometimes their presence is suspected due to missing permanent dentition. We report a case of an 18-year-old female patient with missing mandibular molars on the left side associated with a giant complex odontoma. Treatment included surgical excision of the tumor followed by reconstruction with iliac crest graft. Histopathological study revealed it as an AFO, to our surprise.

  9. Ameloblastic fibroodontoma or complex odontoma: Two faces of the same coin

    Science.gov (United States)

    Singh, Akhilesh Kumar; Kar, Indu Bhusan; Mishra, Niranjan; Sharma, Parikshit

    2016-01-01

    An ameloblastic fibroodontoma (AFO) is a rare odontogenic tumor of mixed dental tissue origin. It exhibits histological features of ameloblastic fibroma and complex odontoma. AFOs are usually found to be asymptomatic and are most often discovered on routine radiography. Sometimes their presence is suspected due to missing permanent dentition. We report a case of an 18-year-old female patient with missing mandibular molars on the left side associated with a giant complex odontoma. Treatment included surgical excision of the tumor followed by reconstruction with iliac crest graft. Histopathological study revealed it as an AFO, to our surprise. PMID:28163488

  10. Radiologic evaluation of an unusually sized complex odontoma involving the maxillary sinus by cone beam computed tomography.

    Science.gov (United States)

    Isler, Sabri Cemil; Demircan, Sabit; Soluk, Merva; Cebi, Zerrin

    2009-01-01

    As a group, odontomas are the most common odontogenic neoplasms. This case report illustrates the benefits of cone beam computed tomography, in terms of treatment planning and surgical technique, to localize a large maxillary odontoma and accurately establish its relationship with the maxillary sinus and molar.

  11. Complex and compound odontomas: Analysis of 69 cases and a ...

    African Journals Online (AJOL)

    2015-02-26

    Feb 26, 2015 ... The treatment of choice is surgical removal of the odontoma. In the .... located in the area of lower second or third molars. There ... There was a history of swelling in the left ... of pain, infection, erythema or ulceration [Figure 1].

  12. Complex odontoma: report of a five-year follow-up case.

    Science.gov (United States)

    Barros, Luciana D'azevedo; Pedron, Irineu Gregnanin; Utumi, Estevam Rubens; Zambon, Camila Eduarda; Rocha, Andre Caroli

    2010-01-01

    Odontomas are odontogenic tumors that usually present as benign lesions. They are easily diagnosed and affect individuals in their first and second decades of life. In most cases, odontomas are asymptomatic and the presence could be suspected due to the delay in tooth eruption or via routine radiographic examinations. Treatment of choice has been surgical removal of the lesion, and prognosis is usually favorable because of its benign characteristics and rare recurrence. The purpose of this study is to report the case of a complex odontoma in a child impacting a permanent molar and preventing its eruption. The lesion was surgically removed, and the eruption of the permanent mandibular left second molar tooth occurred after 5 months. Clinical, radiographic, and histopathological characteristics were studied in this case.

  13. Treatment and Follow-up of a Complex Odontoma. A Case Report

    Directory of Open Access Journals (Sweden)

    Haidée Tamara Díaz Méndez

    2016-08-01

    Full Text Available Odontoma is the most common odontogenic tumor in the oral cavity. It consists of a mixture of odontogenic cells that form dentin and enamel. We present the case of a 12-year-old patient with retention of the upper right central incisor caused by a complex odontoma. Surgical enucleation of the odontoma was performed and follow-up was conducted mainly through radiographic studies. During this time, the patient wore an esthetic space maintainer. Eight months later, she underwent surgery to bond an orthodontic button on the vestibular surface of the tooth number 11. In the presence of the newly formed bone, a fixed appliance was placed in the upper arch to move and align the tooth in the dental arch. This type of lesion, which constitutes one of the causes of tooth retention, can be managed successfully by both surgical and orthodontic treatment.

  14. Extensive complex odontoma in the maxillary sinus pushing 3rd molar near the orbital floor causing transient diplopia and chronic sinusitis: a rare presentation and surgical management.

    Science.gov (United States)

    Gupta, Monika; Das, Debdutta

    2015-03-01

    Odontoma is a mixed odontogenic hamartoma involving both epithelial and mesenchymal tissues. If left untreated, it can lead to complications in certain conditions. Here is a rare presentation of an extensive complex odontoma in maxillary sinus pushing third molar near the orbital floor causing transient diplopia in upward gaze occasionally and chronic sinusitis. Although odontomata are not uncommon and are familiar to practitioners, but some aggressive cases may cause problematic sequelae. Even postoperative complications may result if oral surgeons are not aware of the potential pitfalls associated with the surgical removal of large maxillary antrum odontomata. This article reports a rare presentation which can be considered unique because when obstruction of sinus drainage is evident, serious complications such as orbital infections, epidural and subdural empyema, meningitis, cerebritis, cavernous sinus thrombosis, brain abscess and death can occur. It also addresses points and pitfalls concerning surgery to remove odontoma.

  15. Cemento-osseous dysplasia-like lesion and complex odontoma associated with an impacted third molar.

    Science.gov (United States)

    Prodromidis, Georgios I; Tosios, Konstantinos I; Koutlas, Ioannis G

    2011-12-01

    We present a case of a 36-year-old female with a benign fibro-osseous lesion consistent with cemento-osseous dysplasia (COD) that was located coronally to the crown of an impacted mandibular third molar tooth and was associated with a complex odontoma. The pathogenesis of this unusual association is discussed and the odontogenic origin of COD is suggested.

  16. Radiographic study of the odontoma

    Energy Technology Data Exchange (ETDEWEB)

    Ahn, Hyung Kyu [Department of Oral Radiology, College of Dentistry, Seoul National University, Seoul (Korea, Republic of)

    1983-11-15

    The author studied clinically and radiologically 55 cases which had been diagnosed as odontoma in SNUDH. The obtained results were as follows: 1. In sex distribution, there was no prevalence in both sexes. And the incidence was the highest in the 2nd decade (16 patient, 29%). 2. There were 42 cases of compound odontoma (76%) and 13 cases of complex odontoma (24%). In most cases, compound odontoma was located at the anterior portion (34 cases, 81%) and complex odontoma at the posterior portions (9 cases, 69%). 3. There was no apparent clinical symptom in compound odontoma (83%), but in complex odontoma, 80% of cases show swelling. 4. The adjacent root resorption was not observed in any case. 5. Five cases radiographically diagnosed as cystic odontoma were not confirmed histopathologically.

  17. Calcifying Odontogenic Cyst with Complex Odontoma: Histological and Immunohistochemical Features

    Directory of Open Access Journals (Sweden)

    Nooshin Mohtasham

    2013-01-01

    Full Text Available The calcifying odontogenic cyst (COC is a rare odontogenic cyst. Only 2% of all odontogenic cysts and tumors are COC. COC associated with odontoma (COCaO reported in 24% of COCs. COCaO presents a greater incidence in female, with a ratio of 2 to 1. The highest incidence of COCaO occurs during the second decade with a mean age of 16 years, most frequently occurring in the maxilla (61.5%. Here, we describe a classic case of COCaO of the maxillary incisor-canine region in 17-year-old girl, and discuss the clinicopathological features and immunohistochemical finding of this tumor.

  18. Calcifying Odontogenic Cyst with Complex Odontoma: Histological and Immunohistochemical Features

    Directory of Open Access Journals (Sweden)

    Mohsen Merati

    2012-09-01

    Full Text Available The calcifying odontogenic cyst (COC is a rare odontogenic cyst. Only 2% of all odontogenic cysts and tumors are COC. COC associated with odontoma (COCaO reported in 24% of COCs. COCaO presents a greater incidence in female, with a ratio of 2 to 1. The highest incidence of COCaO occurs during the second decade with a mean age of 16 years, most frequently occurring in the maxilla (61.5%. Here, we describe a classic case of COCaO of the maxillary incisor-canine region in 17-year-old girl, and discuss the clinicopathological features and immunohistochemical finding of this tumor.

  19. Central ossifying fibroma, periapical cemento-osseous dysplasia and complex odontoma occurring in the same jaw

    Directory of Open Access Journals (Sweden)

    Farzaneh Agha Hosseini

    2011-05-01

    Full Text Available Central ossifying fibroma is a rare, benign fibro-osseous lesion that arises from the periodontal ligament. Periapical cemento-osseous dysplasia is another variant of fibro-osseous lesion which occurs in the anterior region of the mandible of females. Odontoma is a benign odontogenic tumor that contains enamel, dentine cement and pulp tissue. A 46-year-old woman was referred to the Department of Oral Medicine, School of Dentistry, Tehran University of Medical Sciences, with two nonpainful swellings on both sides of the mandible, which had been slowly growing over a period of one year. Our differential diagnosis was florid cemento-osseous dysplasia, focal cemento-osseous dysplasia for the right side, complex odontoma for the left side and periapical cement-osseous dysplasia for the anterior side. The historical feature revealed ossifying fibroma, complex odontoma and periapical cemento-osseous dysplasia. The occurrence of these three lesions in the same jaw has been rarely reported in the literature. The relationship between the occurrence of these three lesions is not obvious it could be coincidental. It seems that more case reports are needed to establish the relationship between them.

  20. Clinical, pathological, and genetic evaluations of Chinese patient with otodental syndrome and multiple complex odontoma

    Science.gov (United States)

    Liu, Anqi; Wu, Meiling; Guo, Xiaohe; Guo, Hao; Zhou, Zhifei; Wei, Kewen; Xuan, Kun

    2017-01-01

    Abstract Otodental syndrome is a rare autosomal-dominant disease characterized by globodontia, associated with sensorineural, high-frequency hearing loss. Here, we describe the clinical, pathological, and genetic evaluations of a 9-year-old girl with otodental syndrome and multiple complex odontoma. The patient presented with a draining sinus tract in her left cheek, globodontia, and hearing loss. The odontomas which caused the cutaneous sinus tracts were extracted because of the odontogenic infection. The extracted odontoma and primary tooth was studied by micro-CT and further observed histopathologically. The micro-CT findings revealed that the primary tooth had three crowns with two separated pulp chambers, and their root canals were partially fused. The histological findings showed abnormal morphologies of odontoblasts and dentin, hyperplasia of enamel, and malformation of odontogenic epithelium. Furthermore, DNA sequencing and analyze of deafness associated gene GJB2, GJB3, and PDS had not revealed any SNP or mutation; but exon 3 of the causative gene FGF3 could not be amplified, which may be associated with the microdeletion at chromosome 11q13.3. Three month after surgery, the patient was found to be asymptomatic and even the evidence of the extra-oral sinus had disappeared. The dental abnormality of otodental syndrome included congenital missing teeth, globodontia, and multiple complex odontoma. Globodontia exhibited characteristic features of fusion teeth. In addition, gene FGF3 haploinsufficiency was likely to be the cause of otodental syndrome. The report provides some new information in the field of otodental syndrome, which would make dentists more familiar with this disease. PMID:28151902

  1. Complex Odontoma: A Case Report with Micro-Computed Tomography Findings

    Directory of Open Access Journals (Sweden)

    L. A. N. Santos

    2016-01-01

    Full Text Available Odontomas are the most common benign tumors of odontogenic origin. They are normally diagnosed on routine radiographs, due to the absence of symptoms. Histopathologic evaluation confirms the diagnosis especially in cases of complex odontoma, which may be confused during radiographic examination with an osteoma or other highly calcified bone lesions. The micro-CT is a new technology that enables three-dimensional analysis with better spatial resolution compared with cone beam computed tomography. Another great advantage of this technology is that the sample does not need special preparation or destruction in the sectioned area as in histopathologic evaluation. An odontoma with CBCT and microtomography images is presented in a 26-year-old man. It was first observed on panoramic radiographs and then by CBCT. The lesion and the impacted third molar were surgically excised using a modified Neumann approach. After removal, it was evaluated by histopathology and microtomography to confirm the diagnostic hypothesis. According to the results, micro-CT enabled the assessment of the sample similar to histopathology, without destruction of the sample. With further development, micro-CT could be a powerful diagnostic tool in future research.

  2. Complex Odontoma: A Case Report with Micro-Computed Tomography Findings

    Science.gov (United States)

    Santos, L. A. N.; Roque-Torres, G. D.; Oliveira, V. F.; Freitas, D. Q.

    2016-01-01

    Odontomas are the most common benign tumors of odontogenic origin. They are normally diagnosed on routine radiographs, due to the absence of symptoms. Histopathologic evaluation confirms the diagnosis especially in cases of complex odontoma, which may be confused during radiographic examination with an osteoma or other highly calcified bone lesions. The micro-CT is a new technology that enables three-dimensional analysis with better spatial resolution compared with cone beam computed tomography. Another great advantage of this technology is that the sample does not need special preparation or destruction in the sectioned area as in histopathologic evaluation. An odontoma with CBCT and microtomography images is presented in a 26-year-old man. It was first observed on panoramic radiographs and then by CBCT. The lesion and the impacted third molar were surgically excised using a modified Neumann approach. After removal, it was evaluated by histopathology and microtomography to confirm the diagnostic hypothesis. According to the results, micro-CT enabled the assessment of the sample similar to histopathology, without destruction of the sample. With further development, micro-CT could be a powerful diagnostic tool in future research. PMID:27293913

  3. Complex Odontoma: A Case Report with Micro-Computed Tomography Findings.

    Science.gov (United States)

    Santos, L A N; Lopes, L J; Roque-Torres, G D; Oliveira, V F; Freitas, D Q

    2016-01-01

    Odontomas are the most common benign tumors of odontogenic origin. They are normally diagnosed on routine radiographs, due to the absence of symptoms. Histopathologic evaluation confirms the diagnosis especially in cases of complex odontoma, which may be confused during radiographic examination with an osteoma or other highly calcified bone lesions. The micro-CT is a new technology that enables three-dimensional analysis with better spatial resolution compared with cone beam computed tomography. Another great advantage of this technology is that the sample does not need special preparation or destruction in the sectioned area as in histopathologic evaluation. An odontoma with CBCT and microtomography images is presented in a 26-year-old man. It was first observed on panoramic radiographs and then by CBCT. The lesion and the impacted third molar were surgically excised using a modified Neumann approach. After removal, it was evaluated by histopathology and microtomography to confirm the diagnostic hypothesis. According to the results, micro-CT enabled the assessment of the sample similar to histopathology, without destruction of the sample. With further development, micro-CT could be a powerful diagnostic tool in future research.

  4. Odontoma: a retrospective study of 73 cases

    Energy Technology Data Exchange (ETDEWEB)

    An, Seo Young; An, Chang Hyeon; Choi, Karp Shik [School of Dentistry, Kyungpook National University, Daegu (Korea, Republic of)

    2012-06-15

    The purpose of the present study was to retrospectively evaluate the clinical findings and treatment results for impacted permanent teeth associated with odontomas. We retrospectively investigated 73 odontomas in 72 patients who visited Kyungpook National University Dental Hospital from April 2004 through November 2011. The study was performed using medical records, panoramic radiographs, and pathological reports. Data gathered included age, gender, location, chief complaints, effects on dentition, and treatment of odontoma and the impacted tooth associated with odontoma. Most compound odontomas (46.7%) were found in the second decade and complex odontomas were not related to age. Odontomas showed no gender predilection. Fifty-five cases (75.3%) of odontomas were detected on routine dental radiographs. Sixty percent of compound odontomas occurred in the canine area and 57.1% of complex odontomas in the molar areas. Impaction of permanent teeth (61.6%) was the most common complication on the adjacent teeth. Most odontomas (84.9%) were removed surgically and impacted permanent teeth were managed by surgical removal (53.2%), orthodontic treatment (25.5%), or surgical repositioning (6.4%). There was a statistically significant relation between age and preservation of the impacted permanent teeth associated with odontomas (p<0.01). Early detection and treatment of odontomas increase the possibility of preservation of the impacted tooth. Therefore, it would be suggested that periodic panoramic examination during the first and second decade of life might be beneficial for the early detection and better prognosis of odontomas.

  5. An alternative treatment option for a bony defect from large odontoma using recycled demineralization at chairside.

    Science.gov (United States)

    Lee, JuHyon; Lee, Eun-Young; Park, Eun-Jin; Kim, Eun-Suk

    2015-04-01

    Odontoma is the most common odontogenic benign tumor, and the treatment of choice is generally surgical removal. After excision, bone grafts may be necessary depending on the need for further treatment, or the size and location of the odontoma. Although the osteogenic capacity of a demineralized tooth was verified as early as 1967 by Urist and many other investigators, the cumbersome procedure, including a long demineralization time, may be less than comfortable for clinicians. A modified ultrasonic technology, with periodic negative pressure and temperature control, facilitated rapid and aseptic preparation of demineralized teeth for bone grafts. This approach reduces the demineralization time dramatically (≤80 minutes), so that the graft material can be prepared chairside on the same day as the extraction. The purpose of this article is to describe two cases of large compound odonotomas used as graft material prepared chairside for enucleation-induced bony defects. These two clinical cases showed favorable wound healing without complications, and good bony support for future dental implants or orthodontic treatment. Finally, this report will suggest the possibility of recycling the benign pathologic hard tissue as an alternative treatment option for conventional bone grafts in clinics.

  6. Complex odontoma with dentigerous cyst:a case report%混合性牙瘤合并含牙囊肿1例

    Institute of Scientific and Technical Information of China (English)

    徐其章; 张红亮; 王晓宇; 王占基; 徐倩倩; 马琼

    2014-01-01

    混合性牙瘤是一种比较少见的牙齿发育异常,混合性牙瘤合并含牙囊肿更是少见。本文报道1例混合性牙瘤合并含牙囊肿病例。%Complex odontoma is a relatively rare dental dysplasia. In particular, a complex odontoma with dentigerous cyst is seldom observed. A case of complex odontoma with dentigerous cyst is reported in this paper.

  7. Orthodontic management of an impacted maxillary incisor due to odontoma

    Directory of Open Access Journals (Sweden)

    Rahul S Baldawa

    2011-01-01

    Full Text Available Odontomas are a heterogeneous group of jaw bone lesions, classified as odontogenic tumors which usually include well-diversified dental tissues. Odontomas are the most common type of odontogenic tumors and generally they are asymptomatic. Two types of odontomas are described: compound and complex based on either the appearance of well-organized tooth-like structures (compound odontomas or on a mass of disorganized odontogenic tissues (complex odontomas. Compound odontomas have a predilection for the anterior maxilla, whereas complex odontomas have a predilection for the posterior mandible. Odontomas frequently interfere with eruption of teeth leading to their impaction. This is a case report of a 14-year-old girl with an unerupted maxillary right central incisor due to a complex composite odontoma a rare occurrence in anterior maxilla. Surgical excision of the odontoma and orthodontic treatment to get the impacted maxillary right central incisor into alignment is discussed.

  8. Calcifying odontogenic cyst associated with complex odontoma: case report and review of the literature.

    Science.gov (United States)

    Gallana-Alvarez, Silvia; Mayorga-Jimenez, Francisco; Torres-Gómez, Francisco Javier; Avellá-Vecino, Francisco Javier; Salazar-Fernandez, Clara

    2005-01-01

    We report a calcifying odontogenic cyst associated with odontoma (COCaO) and an included permanent canine in the superior maxilla, in a 19 year-old-man. The calcifying odontogenic cyst (COC) was first described as a distinct entity by Gorlin et al in 1962. The lesion is a mixed odontogenic benign tumor, and although most of the cases present cystic characteristics, a few are of the solid type (15%), and its rare malignant transformation is well documented. The COC may occur in association with other odontogenic tumors, the most common is the odontoma, occurring in about 24% of the cases. For this association the term Odontocalcifying odontogenic cyst has been suggested. Radiographically is a well defined mixed lesion and histologically consists of a large cyst. In the central area of the cyst enamel and dentin deposits can be found, irregularly distributed in areas and in other parts it takes on a well defined organoid aspect. A thorough review of literature takes place and the pathogenesis is discussed.

  9. Calcifying odontogenic cyst of anterior maxilla with complex odontoma

    Directory of Open Access Journals (Sweden)

    Yadavalli Guruprasad

    2014-01-01

    Full Text Available Calcifying odontogenic cyst (COC is an unusual and unique lesion with characteristics of a solid neoplasm and of a cyst. It shows considerable amount of histopathological diversity, with variable clinical behavior such as cystic, neoplastic and infiltrating malignant behavior. It is a rare developmental odontogenic cyst with notable presence of histopathological features, which include a cystic lining demonstrating characteristic "Ghost" epithelial cells with a propensity to calcify. Odontomes are best known as hamartomatous benign tumors rather than true neoplasms, arising from odontogenic tissues. Histologically, they are classified as compound and complex variety. We report a rare case of COC of anterior maxilla with complex odontome in a 12-year-old female child.

  10. Large ameloblastic fibro-odontoma in an 18-year-old girl and review of literature.

    Science.gov (United States)

    Pillai, Ajay; Moghe, Swapnil; Guru, Kanishka Navin; Nair, Preeti P

    2012-11-19

    The ameloblastic fibro-odontoma is a rare, benign, mixed neoplasm composed of proliferating odontogenic epithelium, ectomesenchymal tissue and varying degrees of dental hard tissue formation. It occurs exclusively as an intraosseous lesion. It usually exhibits slow growth and is commonly seen in children and young adults. Radiologically, ameloblastic fibro-odontoma appears as a circumscribed radiolucency which may contain radiopaque foci. Most cases of ameloblastic fibro-odontoma exhibit benign behaviour, but cases of malignant transformation have been reported. The treatment modality in most cases involves conservative surgery, but in cases with malignant transformation more radical treatment will be required. A massive ameloblastic fibro-odontoma involving the mandible is being described here with its clinical, radiological and histopathological features.

  11. Central ossifying fibroma, periapical cemento-osseous dysplasia and complex odon-toma occurring in the same jaw.

    Science.gov (United States)

    Hosseini, Farzaneh Agha; Moslemi, Elham

    2011-05-16

    Central ossifying fibroma is a rare, benign fibro-osseous lesion that arises from the periodontal ligament. Periapical cemento-osseous dysplasia is another variant of fibro-osseous lesion which occurs in the anterior region of the mandible of females. Odontoma is a benign odontogenic tumor that contains enamel, dentine cement and pulp tissue. A 46-year-old woman was referred to the Department of Oral Medicine, School of Dentistry, Tehran University of Medical Sciences, with two non-painful swellings on both sides of the mandible, which had been slowly growing over a period of one year. Our differential diagnosis was florid cemento-osseous dysplasia, focal cemento-osseous dysplasia for the right side, complex odontoma for the left side and periapical cement-osseous dysplasia for the anterior side. The historical feature revealed ossifying fibroma, complex odontoma and periapical cemento-osseous dysplasia. The occurrence of these three lesions in the same jaw has been rarely reported in the literature. The relationship between the occurrence of these three lesions is not obvious it could be coincidental. It seems that more case reports are needed to establish the relationship between them.

  12. Clinical, pathological, and genetic evaluations of Chinese patient with otodental syndrome and multiple complex odontoma: Case report.

    Science.gov (United States)

    Liu, Anqi; Wu, Meiling; Guo, Xiaohe; Guo, Hao; Zhou, Zhifei; Wei, Kewen; Xuan, Kun

    2017-02-01

    Otodental syndrome is a rare autosomal-dominant disease characterized by globodontia, associated with sensorineural, high-frequency hearing loss. Here, we describe the clinical, pathological, and genetic evaluations of a 9-year-old girl with otodental syndrome and multiple complex odontoma.The patient presented with a draining sinus tract in her left cheek, globodontia, and hearing loss. The odontomas which caused the cutaneous sinus tracts were extracted because of the odontogenic infection. The extracted odontoma and primary tooth was studied by micro-CT and further observed histopathologically. The micro-CT findings revealed that the primary tooth had three crowns with two separated pulp chambers, and their root canals were partially fused. The histological findings showed abnormal morphologies of odontoblasts and dentin, hyperplasia of enamel, and malformation of odontogenic epithelium. Furthermore, DNA sequencing and analyze of deafness associated gene GJB2, GJB3, and PDS had not revealed any SNP or mutation; but exon 3 of the causative gene FGF3 could not be amplified, which may be associated with the microdeletion at chromosome 11q13.3. Three month after surgery, the patient was found to be asymptomatic and even the evidence of the extra-oral sinus had disappeared.The dental abnormality of otodental syndrome included congenital missing teeth, globodontia, and multiple complex odontoma. Globodontia exhibited characteristic features of fusion teeth. In addition, gene FGF3 haploinsufficiency was likely to be the cause of otodental syndrome. The report provides some new information in the field of otodental syndrome, which would make dentists more familiar with this disease.

  13. A Radiographic Study of Odontoma

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Kyung Ho; Choi, Karp Shik [Dept. of Dental Radiology, College of Dentistry, Kyungpook National University, Daegu (Korea, Republic of)

    1998-02-15

    The purpose of this study was to obtain information on the clinical and radiographic features of the odontomas in the jaws. For this study, the authors examined and analyzed the clinical records and radiographs of 119 patients who had lesion of odontoma diagnosed by clinical and radiographic examinations. The obtained results were as follows: 1. Odontoma occurred the most frequently in the 2nd decade (45.4%) and occurred more frequently in males (60.5%) than in females (39.5%). 2. The most common clinical symptom was the delayed eruption of the teeth (34.2%). 3. The type of lesions was mainly observed as compound odontoma (80.8%), and internal pattern of the complex odontoma was unevenly radiopaque (73.9%). 4. The compound odontoma frequently occurred in anterior portion of the maxilla (57.7%) and mandible (30.9%), and complex odontoma frequently occurred in anterior portion of maxilla (34.8%) and posterior portion of mandible (30.5%). 5. The effects on adjacent teeth were impaction of teeth (71.7%) and prolonged retention of deciduous teeth (31.7%). 6. The impaction of the teeth occurred in anterior portion of maxilla (44.2%) amd mandible (19.2%), but root resorption of the adjacent teeth were not seen. 7. The boundary to adjacent structure was well-defined , the lesions appear as radiopaque mass with radiolucent rim.

  14. Large ameloblastic fibro-odontoma in a 3 year- old child: case report

    Directory of Open Access Journals (Sweden)

    Laurindo Moacir Sassi

    2011-01-01

    Full Text Available Introduction: The ameloblastic fibro-odontoma is a rare mixed neoplasm composed of proliferating odontogenic epithelium, ectomesenchymal tissue, and varying degrees of dental hard tissue formation. The mean age of the incidence is from 8-12 years and there is no gender or anatomic site predilection, but it is most commonly found in children’s or teenager’s jaws. Case report: A 3-year-old female patient showed a swelling in anterior maxilla, with facial asymmetry. Radiographically, it presented as a mixed lesion with undefined limits. Clinical hypothesis was odontoma. Enucleating surgery was conducted with tooth germs preservation. The final diagnosis was ameloblastic fibro-odontoma. No recurrence was observed at 1-year follow-up period, and the permanent tooth germs were correctly positioned for eruption. Conclusion: Although ameloblastic fibro-odontoma is a benign lesion, it developed in a very early age, with rapid growth and destruction of cortical bone. Proper surgical enucleation allowed the teeth maintenance.

  15. Odontoma serie de casos: Revisión de literatura Odontoma case series: Review of literature

    Directory of Open Access Journals (Sweden)

    J. Harris Ricardo

    2011-02-01

    Full Text Available El odontoma es el tumor odontogénico más frecuente en cavidad oral, compuesto por una mezcla de células odontogénicas formando dentina y esmalte, presenta células y tejidos normales pero de estructura defectuosa, estos tejidos se encuentran en el área del cuerpo donde se presenta su crecimiento, al examen radiográfico se puede presentar imágenes radiopacas como un gran número de dientes rudimentarios llamados dentículos, en este caso se conoce como odontoma compuesto o presentarse imagen radiopaca como conglomeraciones amorfas, recibiendo el nombre de odontoma complejo. Su etiología se le relaciona con restos paradentales de Malassez, procesos inflamatorios, traumatismos, se le asocia en algunos casos con el quiste odontogénico calcificante, son asintomáticos, producen retención dentaria. El tratamiento es quirúrgico y su recurrencia es baja. Se reporta serie de casos que acudieron al servicio de estomatología y cirugía oral de la Universidad de Cartagena con impresión diagnostica de odontoma, se realizaron los procedimientos quirúrgicos confirmando los diagnósticos con los reportes histopatológicos.Odontoma is the most frequent odontogenic tumor in oral cavity, comprising a mixture of odontogenic cells forming dentin and enamel. It shows cells and normal tissues but in abnormal structure. These tissues are located in the area of the body where it presents its growth. Under radiographic examination may be radiopaque images as a large number of rudimentary teeth called denticles, in this case is known as compound odontoma or presented as conglomerates amorphous radiopaque image, receiving the name of complex odontoma. Its etiology is related to remnants of Malassez paradontals, inflammatory processes. Trauma is sometimes associated with calcifying odontogenic cyst. Generally are asymptomatic, produce tooth retention. Treatment is surgical and recurrence is low. Is reported in the present paper a number of cases that went to

  16. Odontomas in the primary dentition: literature review and case report.

    Science.gov (United States)

    Sheehy, Evelyn C; Odell, Edward W; Al-Jaddir, Ghaida

    2004-01-01

    Odontomas are hamartomatous developmental malformations of dental tissues. They are very rarely diagnosed in the primary dentition. The purpose of this paper was to review the literature in relation to odontomas in the primary dentition, and describe the dental management of a child, age 4 years and 8 months, who had a complex odontoma.

  17. Compound odontoma

    Directory of Open Access Journals (Sweden)

    Monica Yadav

    2012-01-01

    Full Text Available Odontomas have been extensively reported in the dental literature, and the term refers to tumors of odontogenic origin. Though the exact etiology is still unknown, the postulated causes include: local trauma, infection, inheritance and genetic mutation. The majority of the lesions are asymptomatic; however, may be accompanied with pain and swelling as secondary complaints in some cases. Here, we report a case of a compound odontome in a 14 year old patient.

  18. Compound Composite Odontoma and Its Management

    Directory of Open Access Journals (Sweden)

    Morawala Abdul

    2014-01-01

    Full Text Available Odontomas are odontogenic benign tumors composed of dental tissue. Majority of these lesions are asymptomatic and are often detected on routine radiographs. They can be thought of as “tooth hamartomas" with the lesion consisting of various tooth components. They are divided histologically into complex odontomas and compound odontomas. This paper describes the case of a compound odontoma in a 13-year-old girl diagnosed due to the retention of the primary right mandibular second molar. A surgical excision was performed without disturbing the unerupted premolar. The results achieved indicate that early diagnosis of odontomas enables adoption of less complex treatment, a better prognosis, and displacement or devitalisation of adjacent tooth.

  19. Submandibular cellulitis (Ludwig's angina) associated to a complex odontoma erupted into the oral cavity. Case report and literature review.

    Science.gov (United States)

    Bertolai, R; Acocella, A; Sacco, R; Agostini, T

    2007-01-01

    The clinical presentation of Ludwig's angina consists in a severe expanding cellulitis causing swelling of the floor of the mouth, tongue and submandibular region, thus resulting in a possible obstruction of the airway and in a rapid progress in deep neck soft tissue infection and mediastinitis with potentially fatal consequences. Frequently, submandibular cellulitis develops from an acute infection spreading from the lower molar teeth. Mandibular fractures, traumatic laceration of the floor of the mouth, and peritonsillar abscesses are other concomitant clinical features. A case of Ludwig's angina associated with a large erupted odontoma and with a deeply impacted third molar displaced to the border of the mandible is described. The patient was affected by enlargement of submandibular space, marked face swelling causing an evident face deformity, tenderness and redness of the neck and limited movement of the neck and mouth. In the past, Ludwig's angina was frequently fatal, however aggressive surgical and medical therapy have significantly reduced the mortality rate. The reported case can be considered as important, not only because of the rarity of the odontoma eruption in the oral cavity, but mainly for the extent of the clinical manifestation of a lesion usually described in literature as asymptomatic.

  20. Surgical Management of Compound Odontoma Associated with Unerupted Tooth

    Directory of Open Access Journals (Sweden)

    Andrea Pacifici

    2015-01-01

    Full Text Available Odontomas represent the most common type of odontogenic benign jaws tumors among patients younger than 20 years of age. These tumors are composed of enamel, dentine, cementum, and pulp tissue. According to the World Health Organization classification, two distinct types of odontomas are acknowledged: complex and compound odontoma. In complex odontomas, all dental tissues are formed, but appeared without an organized structure. In compound odontomas, all dental tissues are arranged in numerous tooth-like structures known as denticles. Compound odontomas are often associated with impacted adjacent permanent teeth and their surgical removal represents the best therapeutic option. A case of a 20-year-old male patient with a compound odontoma-associated of impacted maxillary canine is presented. A minimally invasive surgical technique is adopted to remove the least amount of bone tissue as far as possible.

  1. Surgical Management of Compound Odontoma Associated with Unerupted Tooth.

    Science.gov (United States)

    Pacifici, Andrea; Carbone, Daniele; Marini, Roberta; Pacifici, Luciano

    2015-01-01

    Odontomas represent the most common type of odontogenic benign jaws tumors among patients younger than 20 years of age. These tumors are composed of enamel, dentine, cementum, and pulp tissue. According to the World Health Organization classification, two distinct types of odontomas are acknowledged: complex and compound odontoma. In complex odontomas, all dental tissues are formed, but appeared without an organized structure. In compound odontomas, all dental tissues are arranged in numerous tooth-like structures known as denticles. Compound odontomas are often associated with impacted adjacent permanent teeth and their surgical removal represents the best therapeutic option. A case of a 20-year-old male patient with a compound odontoma-associated of impacted maxillary canine is presented. A minimally invasive surgical technique is adopted to remove the least amount of bone tissue as far as possible.

  2. An erupted compound odontoma.

    Science.gov (United States)

    Gupta, Anil; Vij, Hitesh; Vij, Ruchieka; Malhotra, Ritika

    2014-04-12

    Odontomas are familiar entities but their eruption into the oral cavity is an extraordinary occurrence, which may be associated with pain, infection, malocclusion, etc. Not many cases of erupted odontomas have been reported in the literature. This paper puts forth a case of erupting odontoma in an attempt to add to the list of reported cases of this unique pathology.

  3. Amelobastic odontoma occurred in the mandible

    Energy Technology Data Exchange (ETDEWEB)

    Ha, SSang Yong; Song, Nam Kyu; Koh, Kwang Joon [Dept. of Oral and Maxillofacial Radiology, College of Dentistry, Chonbuk National University, Chonju (Korea, Republic of)

    1996-08-15

    Amelobastic odontoma is a mixed odontogenic tumor, which is characterized as being extremely rare, displaying aggressive clinical behavior, resembling a mixed radiopaque and radiolucent radiographic appearance and containing both amel oblastoma and a composite odontoma. Seven-year-old boy complaining of delayed eruption of the left lower permanent 1st molar came to the department of Oral and Maxillofacial radiology at Chonbuk National University Hospital. The list of our radiographic differential diagnosis included the dental follicle, compound odontoma, complex odontoma and cystic odontoma. The microscopic analysis showed the lesion with the characteristics of an ameloblastic odontoma. the obtained results were as follows : 1. The area was asymptomatic, but the delayed eruption of the left lower permanent 1st molar was observed. 2. Radiographically, well-defined widened pericoronal radiolucency containing several tooth-like radiopacities involving the impacted left lower permanent 1st molar and well-defined round radiolucency containing irregular radiopaque mass were observed. 3. Histopathologically, several tooth-lile structures, odontoma components with the area of typical enamel, dentin and pulp, and ameloblastic components with typical follicular amelobastoma were observed.

  4. Ameloblastic fibro-odontoma in the mandible: a case report

    Energy Technology Data Exchange (ETDEWEB)

    An, Chang Hyeon [Kyungpook National University College of Medicine, Daegu (Korea, Republic of)

    2005-03-15

    Ameloblastic fibro-odontoma is a rare benign mixed odontogenic tumor with histologic characteristics of ameloblastic fibroma and complex odontoma. As with ameloblastic fibroma, it may be asymptomatic or found because of painless swelling and delayed eruption of associated tooth. This report presents a case of ameloblastic fibro-odontoma in the posterior mandible of a 14-year-old girl and analyses its clinical features and radiographic features in plain X-ray film and CT images.

  5. Multiple Compond Odontomas in the Jaws: A Rare Case Report.

    Science.gov (United States)

    Gujjar, Pavan Kumar; Sahni, Priya; Pereira, Treville; Zingade, Jyoti

    2015-12-01

    Odontomas are tumours of odontogenic origin. In these tumours both the epithelial and mesenchymal cells undergo differentiation to form enamel and dentin with variable amounts of cementum and pulp tissue. The odontomas represent a hamartoma rather than a neoplasm. When the enamel and dentin are laid down in an organized manner it is termed as a compound odontoma wherein the tumour forms a collection of small structures resembling teeth. On the other hand, an irregular mass with no similarity to teeth is termed as a complex odontoma. There are cases of extensive and multiple compound odontomas which have been identified in either of the jaws. The present case is rare with multiple compound odontomas involving both the jaws of 45-year-old male patient. A review of seven such cases reported so far has been presented.

  6. Multiple Compond Odontomas in the Jaws: A Rare Case Report

    Science.gov (United States)

    Sahni, Priya; Pereira, Treville; Zingade, Jyoti

    2015-01-01

    Odontomas are tumours of odontogenic origin. In these tumours both the epithelial and mesenchymal cells undergo differentiation to form enamel and dentin with variable amounts of cementum and pulp tissue. The odontomas represent a hamartoma rather than a neoplasm. When the enamel and dentin are laid down in an organized manner it is termed as a compound odontoma wherein the tumour forms a collection of small structures resembling teeth. On the other hand, an irregular mass with no similarity to teeth is termed as a complex odontoma. There are cases of extensive and multiple compound odontomas which have been identified in either of the jaws. The present case is rare with multiple compound odontomas involving both the jaws of 45-year-old male patient. A review of seven such cases reported so far has been presented. PMID:26816995

  7. [Ameloblastic fibro-odontoma of the maxillary sinus].

    Science.gov (United States)

    Nouri, H; Raji, A; Ait M'barek, B

    2007-11-01

    Ameloblastic fibro-odontoma, ameloblastic fibroma, and odontoma are rare malformations, which are classified as odontologic tumors. They usually progress in an asymptomatic way, and making the histological distinction between these variants is very difficult. We report the case of a 14-year-old girl presenting with an ameloblastic fibro-odontoma of the maxillary sinus. The clinical signs were nasal obstruction and jugular tumefaction. Surgical excision was performed through a paralateronasal approach. The diagnosis of fibro-odontoma was confirmed by the histopathological analysis of the surgical piece. Odontologic tumors form a complex entity, the histological nature and the correlations of which are discussed.

  8. Mixed odontogenic tumours and odontomas. Considerations on interrelationship. Review of the literature and presentation of 134 new cases of odontomas.

    Science.gov (United States)

    Philipsen, H P; Reichart, P A; Praetorius, F

    1997-03-01

    Based on a world-wide literature survey of published cases of "mixed odontogenic tumours" (ameloblastic fibroma, fibrodentinoma and fibro-odontoma) and complex/compound odontomas (including 134 own cases of odontomas) the authors present data showing the complex nature of these lesions. The authors suggest the following work hypothesis regarding the pathogenesis and relationship between the "mixed odontogenic tumours" and the odontomas. The tumours develop along two separate lines: (I) the neoplastic line comprising only one tumour, the ameloblastic fibroma (AF) and the closely related ameloblastic fibrodentinoma (AFD). (II) The hamartomatous (or the developing complex odontoma (DCO) line comprising: (1) The AF (and AFD). Differences in age and biological behaviour indicate that some AF are true benign neoplasms, whereas others are hamartomas presenting the first stage in the DCO-line. (2) The AF-O represents the second stage of the DCO-line developing into (3) the fully mineralized complex odontoma. Lastly, the authors suggest that the compound odontoma should be considered not as an alternative final stage to the complex odontoma but rather as a malformation (with a high degree of histomorphological differentiation) pathogenetically closely related to the process producing hyperodontia, "multiple schizodontia" or locally conditioned hyperactivity of the dental lamina.

  9. Odontoma and Analysis of 57 different types

    Directory of Open Access Journals (Sweden)

    Baghaei-e- Naeini F

    1999-06-01

    Full Text Available Odontoma is an odontogenic lesion with epithelial and mesenchymal origin and is composed"nof differentiated dental parts. Than because of abnormal organization of mature tissues. It seems that it is"na hamartoma rather than real tumor. Odontoma is seen in two types of compound & complex."nOut of 57 studied cases, 31 cases (54.2% were of complex type; 12 cases (21 % were compound & 8"ncases were of cystic. The age of incidence ranged from 5.5 to 68 years. The mean age in complex"nodontoma was 27 years & compound type was 19 years. There was no significant difference regarding the"nsex in the complex type. In compound odontoma women were affected 2 times more than means."nComplex type are found in mandibular posterior era ereas more and compound type in anterior regions .In"nthis studied found 12 cases impaction teeth.

  10. Large Complex Odontome of Maxilla: Report of a case and Literature Review

    Directory of Open Access Journals (Sweden)

    Geeta Singh

    2015-01-01

    Full Text Available The pathologic al c onditions in which odontogenic differentiation is fully expressed are the odontomas. Odontomas are consi­ dered as hamartomas/developmental anomaly rather than a true neo plasm. These tumors are composed of enamel, dentin, cemen­tum and pulp tissue. They are basically classified into two types, compound and complex. Most compound odontoma are found in the anterior maxilla whereas complex odontomas are commonly found in posterior mandible. We present a rare case of complex odontome in anterior maxilla treated in our center.

  11. Ameloblastic fibro odontoma.

    Science.gov (United States)

    Sivapathasundharam, B; Manikandhan, R; Sivakumar, G; George, Titus

    2005-01-01

    Ameloblastic fibro odontoma is relatively a rare mixed odontogenic tumor comprising of ameloblastic fibroma and ameloblastic odontoma. This group of lesions represent neoplastic and hamartomatous changes. Data regarding age, sex, and site of occurrence of these lesions have been uniquely described. A case of ameloblastic fibro odontoma in a 17-year-old male involving the left body of the mandible, and its radiographic, clinical symptoms and histological features is described herewith. A conservative surgical approach, including enucleation and mechanical curettage of the surrounding bone was done.

  12. Ameloblastic fibro-odontoma

    Directory of Open Access Journals (Sweden)

    L.K. Surej Kumar

    2014-01-01

    CONCLUSION: The possibility of a mixed rare tumour should be kept in mind by the clinician where they deal with the swellings of posterior maxilla in children. Histological assessment revealed a final diagnosis of ameloblastic fibro-odontoma.

  13. Ameloblastic fibro-odontoma of the mandible

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Hyung Wuk; Hwang, Eui Hwan; Lee, Sang Rae [Kyunghee University College of Medicine, Seoul (Korea, Republic of)

    2003-03-15

    Ameloblastic fibro-odontoma is an extremely rare odontogenic tumor composed of proliferating ectodermal and mesenchymal components of odontogenic tissue, containing hard tooth structure. It occurs predominantly in children and young adults. The mandibular molar-ramus area is the most frequently observed location, presenting radiographically as a well-circumscribed and radiolucent-radiopaque tumor. A case involving a 24-year-old woman presenting with a large ameloblastic fibro-odontoma of the posterior mandible is reported. The case is of radiologic interest because two distinct calcification patterns were observed.

  14. Large ameloblastic fibro-odontoma in a 7-year-old girl with analysis of 108 cases

    Science.gov (United States)

    Kirjavainen, Antti; Tuovinen, Veikko; Sándor, George K.

    2016-01-01

    Background: Odontogenic tumors such as ameloblastic fibro-odontoma (AFO) are rare conditions in children and are often asymptomatic. AFOs are found by routine clinical and radiological examination or when they cause obvious intra- or extra-oral swelling. Materials and Methods: A case of an AFO in a 7-year-old girl is described, and 107 cases from the literature and this report are analyzed. Results: The total of 108 cases revealed the average age at presentation of AFO to be 6.3 years in boys and 9.6 years in girls. There was a slight male predilection and AFO lesions most often occurred in the posterior mandible. AFO was almost always associated with an unerupted tooth or teeth. Conclusions: While the recurrence rate of AFO was found to be 5.5%, long-term postoperative clinical and radiological follow-up is advised to ensure no future signs of aggressive recurrence. PMID:27563600

  15. Ameloblastic fibro-odontoma masquerading as odontoma

    Directory of Open Access Journals (Sweden)

    Kanwar Deep Singh Nanda

    2011-01-01

    Full Text Available Ameloblastic fibro-odontoma (AFO is a rare, benign epithelial mixed odontogenic tumor. It occurs as an intraosseous lesion, generally asymptomatic and more prevalent in children and adolescent. AFO is found on radiographic evaluation of patients with unerupted or impacted teeth in many cases. Histological examination reveals a fibrous soft tissue, islands of odontogenic epithelium and a disordered mixture of dental tissues. The treatment modality in most cases involves conservative surgery with enucleation. We present a case of 13-year-old boy with a missing right central incisor, mimicking-like odontoma on radiograph but proved to be AFO and treated with enucleation with preservation of impacted tooth. There was no recurrence after one year of follow-up. This report discusses the clinical, radiographical, histological features and surgical assessment to preserve the impacted tooth associated with AFO.

  16. Ameloblastic fibro-odontoma masquerading as odontoma.

    Science.gov (United States)

    Nanda, Kanwar Deep Singh; Marwaha, Mohita

    2011-01-01

    Ameloblastic fibro-odontoma (AFO) is a rare, benign epithelial mixed odontogenic tumor. It occurs as an intraosseous lesion, generally asymptomatic and more prevalent in children and adolescent. AFO is found on radiographic evaluation of patients with unerupted or impacted teeth in many cases. Histological examination reveals a fibrous soft tissue, islands of odontogenic epithelium and a disordered mixture of dental tissues. The treatment modality in most cases involves conservative surgery with enucleation. We present a case of 13-year-old boy with a missing right central incisor, mimicking-like odontoma on radiograph but proved to be AFO and treated with enucleation with preservation of impacted tooth. There was no recurrence after one year of follow-up. This report discusses the clinical, radiographical, histological features and surgical assessment to preserve the impacted tooth associated with AFO.

  17. Compound odontoma associated with mandibular impacted permanent central incisor: a case report

    Directory of Open Access Journals (Sweden)

    Ugur Gurer

    2012-04-01

    Full Text Available

    Odontomas are the most common benign odontogenic tumors that are hamartomas composed of various dental tissues, and there are two types, complex and compound. Compound odontomas are more prevalent than complex odontomas and consist of many teeth–like structures. Most of such lesions are asymptomatic. These lesions are generally diagnosed by routine radiological examination. The compound type is generally found in the anterior region of the maxilla. The etiology of these lesions has not been precisely explained. If there is absence of any contraindication, the treatment for odontomas is surgical excision.

    This article describes a case of compound odontoma associated with impacted central mandibular right permanent incisor in a 12–year–old female due to trauma. The odontoma was surgically removed with an impacted central incisor.

  18. Odontoma compuesto. Una patología oral a considerar

    Directory of Open Access Journals (Sweden)

    Jonathan Harris Ricardo

    2013-10-01

    Full Text Available Resumen El odontoma es el tumor odontogénico mixto con mayor frecuencia de aparición, las células y los tejidos son normales pero de estructura defectuosa, la etiología se le relaciona con restos paradentales de malassez y traumatismos, son de crecimiento limitado, asintomáticos, producen retención dentaria; se clasifica en compuesto y complejo, radiográficamente se presenta halo radiolúcido con múltiples imágenes radiopacas en su interior, con un patrón ordenado para el odontoma compuesto y en el odontoma complejo se presenta imagen radiopaca como conglomeraciones amorfas, con un patrón desordenado. El tratamiento es quirúrgico y su recurrencia es baja. Se reporta caso de paciente femenina de 30 años de edad, que acudió a la consulta del servicio de estomatología y cirugía oral de la Universidad de Cartagena Colombia, porque presentó, lesión tumoral que comprometía la zona de órganos dentarios 33 y 34, se realizó examen radiográfico, con diagnóstico presuntivo de odontoma compuesto, se programó la cirugía y se realizó enucleación de la lesión tumoral la cual se envió a patología; en el reporte histopatológico se diagnosticó odontoma compuesto. (DUAZARY 2010, 91 - 94Abstract The odontoma is the mixed odontogenic tumor observed with greater frequency. Cells and tissues are normal in structure but is defective in pattern. Etiology is associated with remainders of malassez paradentales tissues and trauma and injuries. They are growing limited, asymptomatic, produce tooth retention. They were classified as compound and complex radiographic radiolucent halo is presented with multiple radiopaque images inside it, with a pattern for the ordered compound odontoma and complex odontoma presents the image as radiopaque amorphous clusters with a disordered pattern. The treatment is surgical and recurrence is low. We report the case of female patient aged 30, who attended the service of dentistry and oral surgery at the

  19. [Should an odontoma be considered as a developing tumor?].

    Science.gov (United States)

    Pouyat, X; Ballon, G; Jobard, P

    1985-01-01

    The authors review the classification of these odontogenic epithelial tumours and propose the hypothesis of a direct relationship between the ameloblastic odontoma and the complex odontoma, which represents the advanced stage of the first tumour. Thus, the odontoma can be considered to be an evolutive tumour. This hypothesis is illustrated by a case report which was associated with confusion concerning the histology. Similar cases in the literature show that the same lesion is described by a variety of names. Ameloblastic odontoma is the most logical terminology and should be the only one used. The appearance of differentiation towards the production of dental tissue in an ameloblastic type of tumour is therefore a good prognostic factor. These tumours predominantly occur in the posterior zones of the bony bases and are usually discovered between the ages of 10 and 30 years.

  20. Erupted odontoma: a case report.

    Science.gov (United States)

    Raval, Nilesh; Mehta, Dhaval; Vachhrajani, Kanan; Nimavat, Abhishek

    2014-07-01

    Odontomas are nonaggressive, hamartomatous developmental malformations or lesions of odontogenic origin, which consist of enamel, dentin, cementum and pulpal tissue 'Erupted odontoma' is a term used to specifically denote odontomas, which are exposed into the oral cavity. These are rare entities with only 25-30 cases being reported so far in the dental literature. Here, we present a rare case of an erupted odontoma in an adolescent patient who came with a complaint of bad aesthetics due to the presence of multiple small teeth like structures in the upper front teeth region.

  1. An Unusual Case Report of Erupted Odontoma

    Directory of Open Access Journals (Sweden)

    Dhaval Mehta

    2013-01-01

    Full Text Available Odontomas are the most common of the odontogenic tumors of the jaws, which are benign, slow growing, and nonaggressive. They are usually asymptomatic and found in routine dental radiographic examination. Odontomas are usually associated with tooth eruption disturbances. Eruption of odontoma in oral cavity is rare entity. Here we report a case of an unusual erupted compound odontoma.

  2. Clinical observations of odontomas in Japanese children: 39 cases including one recurrent case.

    Science.gov (United States)

    Tomizawa, M; Otsuka, Y; Noda, T

    2005-01-01

    Retrospective investigations of odontomas in Japanese children and one recurrent case were carried out. Thirty-nine cases of odontoma in 38 children were treated in the Paediatric Dentistry Clinic of Niigata University Dental Hospital between September 1979 and December 2002. The patients consisted of 23 males and 15 females and their ages ranged from 1 year 2 months to 14 years old. The chief complaints were delayed tooth eruption in 19 cases (five: primary teeth, 14: permanent teeth), retention of primary teeth in 11, incidentally found on the radiographic examination in eight cases, and swelling of the jaw in one case. Thirty-four cases (87%) were associated with tooth eruption disturbances. The most frequently affected region was the maxillary anterior region. Treatment consisted of surgical removal of odontomas in all cases, after which if the impacted teeth did not erupt, exposure of the crown and/or orthodontic traction was performed. Pathological diagnoses were compound odontoma in 30 cases, complex odontoma (n = 7), and compound and complex odontoma (n = 2). A retrospective study of the radiographs revealed the developing process of odontomas in four cases and odontoma disturbed tooth eruption since the early uncalcified developing stage. A recurrent case was a boy aged 6 years 5 months in whom the first surgical removal of odontoma was performed at the age of 1 year 8 months. Recurrence of an odontoma is very rare, but in very young children odontomas are in the early developing stages, containing uncalcified portions, so it is important to perform periodical observations until the succedaneous teeth erupt.

  3. Ameloblastic fibro-odontoma.

    Science.gov (United States)

    Gantala, Ramlal; Gotoor, Srikanth Goud; Kumar, R Vijaya; Munisekhar, M S

    2015-06-04

    Ameloblastic fibro-odontoma is a slow growing, benign, expansile epithelial odontogenic tumour with odontogenic mesenchyme, accounting for 0.3-1.7% of jaw tumours, signifying its rarity. The WHO defines it as "a neoplasm composed of proliferating odontogenic epithelium in a cellular ectomesenchymal tissue with varying degrees of inductive changes and dental hard tissue formation". We report a case of an 11-year-old girl who presented to the Department of Maxillo-Facial Medicine and Radiology for the evaluation of a swelling in the left posterior mandible. Her clinical chart and investigations unveiled it as ameloblastic fibro-odontoma. After a promising presurgical evaluation, the lesion was enucleated using an intraoral approach followed by osteoplasty. Osteogenesis was attained despite of any definitive techniques to promote bone regeneration. Immediate postoperative inter-maxillary fixation was performed to prevent pathological fractures for a period of 3 weeks. In an 8-month follow-up, no untoward complications were noticed.

  4. Ameloblastic Fibro-Odontoma: A Diagnostic Challenge

    Directory of Open Access Journals (Sweden)

    Elen de Souza Tolentino

    2010-01-01

    Full Text Available An 11-year-old girl presented to our department to have a second opinion regarding a lesion involving her left mandible. She had previously undergone several radiographic exams including panoramic, helical, and cone-beam computed tomography. Radiographic examinations revealed a well-defined radiolucent region, which contained an irregular radiopaque mass of 3 cm in diameter, localized to the left angle of the mandible. Our presumptive diagnosis was complex odontoma. Excisional biopsy was performed, and microscopic features showed strands and islands of odontogenic epithelium showing peripheral palisading and loosely arranged central cells, identical to stellate reticulum, embedded in a myxoid cell-rich stroma resembling the dental papilla. Dentin and enamel were also presented. The diagnosis was ameloblastic fibro-odontoma, which is a rare mixed odontogenic tumor, derived from epithelial and ectomesenchymal elements that form the dental tissues.

  5. Tres casos de odontomas

    Directory of Open Access Journals (Sweden)

    Salvador Javier Santos Medina

    2015-03-01

    Full Text Available Los odontomas son los tumores odontogénicos más comunes, casi siempre se diagnostican accidentalmente, en exámenes radiográficos; pueden sospecharse al retardar el brote dentario o producir maloclusiones. Se clasifican en odontomas compuestos y complejos, ambos constituidos por estructuras dentales como: esmalte, dentina, cemento y tejido pulpar. Su eliminación quirúrgica y la biopsia es el tratamiento de elección. El propósito de este trabajo es reportar tres casos de pacientes atendidos en el Hospital Pediátrico de Las Tunas, todos remitidos previamente por el ortodoncista. El primero, tipo compuesto, en un escolar de 9 años de edad, masculino, asociado a un 31 retenido; el segundo caso se trata de un gran odontoma complejo en una escolar de 11 años de edad, femenina, que produjo interferencia en el brote del 11 y el tercero compuesto; en un escolar de 10 años, masculino, en la línea media entre 11 y 21, con producción de diastema y brote del 12 por palatino. De ellos uno fue descubierto por un examen radiográfico de rutina y los otros dos sospechados por la maloclusión secundaria; todos se trataron quirúrgicamente. Estos casos demuestran la frecuencia de estos tumores en la cavidad bucal y la importancia de la realización de exámenes clínicos y radiográficos para su detección y tratamiento precoz, así como la importancia de la interrelación entre el ortodoncista y el maxilofacial en la resolución satisfactoria de esta entidad

  6. [The ameloblastic fibro-odontoma].

    Science.gov (United States)

    Grätz, K W; Makek, M; Sailer, H F

    1991-01-01

    The ameloblastic fibro-odontoma is a rare nonagressive mixed odontogenic tumor. Most of these lesions occur in patients under 20 years. There is no sex predilection. They are located more often in the mandible, usually in the posterior segment. Painless swelling in the most common clinical sign. Radiologically, ameloblastic fibro-odontomas show a circumscribed radiolucency which contains radiopaque foci of various sizes and shapes. Histological examination reveals fibrous soft tissue and islands of odontogenic epithelium. The tumor produces enamel or enamel matrix, dentin and cementum. Treatment of ameloblastic fibro-odontomas usually consists of enucleation or surgical curettage. Eight cases of ameloblastic fibro-odontoma are reported and the clinical features, radiographic and histo-pathologic findings will be discussed along with the 67 cases found in the literature.

  7. Compound odontoma involving the four quadrants of the jaws: a case report and review of the literature.

    Science.gov (United States)

    Erdogan, Özgür; Keceli, Onur; Öztunc, Haluk; Evlice, Burcu; Altug, Hasan Ayberk; Günhan, Ömer

    2014-04-01

    Odontomas are the most common odontogenic tumors, representing 70% of all odontogenic tumors. They may present in two specific forms; compound odontoma forms multiple small tooth-like structures, while complex odontoma forms an amorphous calcified mass. In this report, we present a 27-year-old male patient with multiple compound odontoma occupied regions at his jaws. The odontomas involve both alveolar and basal processes of the maxilla and mandible as well as both maxillary sinuses. Converse to conventional recommended treatment, which is surgical excision of the lesion, the management was removal of the lesion and clinical-radiologic followup. The first year's follow-up findings are presented in this case report.

  8. Cystic Odontoma in a Patient with Hodgkin’s Lymphoma

    Directory of Open Access Journals (Sweden)

    Victor Costa

    2015-01-01

    Full Text Available Cystic odontoma is a rare entity, which is characterized by the association of a cyst with complex/compound odontoma. The aim of this study was to report the case of a 5-year-old male patient diagnosed previously with Hodgkin’s lymphoma and treated successfully with chemotherapy and radiotherapy, who developed a mandibular odontogenic lesion. Physical examination revealed a swelling on the right side of the mandible. Radiographically, a well-defined radiolucent area surrounded by radiopaque material was observed. An incisional biopsy was performed and microscopic analysis showed a cystic lesion consisting of an atrophic epithelium comprising 2-3 cell layers and the absence of inflammation in the cystic capsule. The cyst was decompressed and the lesion was removed after 3 months of follow-up. Microscopic analysis of the surgical specimen showed a cystic hyperplastic epithelium surrounded by an intense chronic inflammatory cell infiltrate, which was in close contact with mineralized tissue resembling dentin and cementum. The final diagnosis was cystic odontoma. Since chemotherapy can affect the growth and development of infant teeth, a relationship between chemotherapy-associated adverse events and cystic odontoma is suggested in the present case.

  9. Cystic Odontoma in a Patient with Hodgkin's Lymphoma

    Science.gov (United States)

    Costa, Victor; Caris, Adriana Rocha; León, Jorge Esquiche; Ramos, Carolina Judica; Jardini, Vaneska; Kaminagakura, Estela

    2015-01-01

    Cystic odontoma is a rare entity, which is characterized by the association of a cyst with complex/compound odontoma. The aim of this study was to report the case of a 5-year-old male patient diagnosed previously with Hodgkin's lymphoma and treated successfully with chemotherapy and radiotherapy, who developed a mandibular odontogenic lesion. Physical examination revealed a swelling on the right side of the mandible. Radiographically, a well-defined radiolucent area surrounded by radiopaque material was observed. An incisional biopsy was performed and microscopic analysis showed a cystic lesion consisting of an atrophic epithelium comprising 2-3 cell layers and the absence of inflammation in the cystic capsule. The cyst was decompressed and the lesion was removed after 3 months of follow-up. Microscopic analysis of the surgical specimen showed a cystic hyperplastic epithelium surrounded by an intense chronic inflammatory cell infiltrate, which was in close contact with mineralized tissue resembling dentin and cementum. The final diagnosis was cystic odontoma. Since chemotherapy can affect the growth and development of infant teeth, a relationship between chemotherapy-associated adverse events and cystic odontoma is suggested in the present case. PMID:26618008

  10. Cystic Odontoma in a Patient with Hodgkin's Lymphoma.

    Science.gov (United States)

    Costa, Victor; Caris, Adriana Rocha; León, Jorge Esquiche; Ramos, Carolina Judica; Jardini, Vaneska; Kaminagakura, Estela

    2015-01-01

    Cystic odontoma is a rare entity, which is characterized by the association of a cyst with complex/compound odontoma. The aim of this study was to report the case of a 5-year-old male patient diagnosed previously with Hodgkin's lymphoma and treated successfully with chemotherapy and radiotherapy, who developed a mandibular odontogenic lesion. Physical examination revealed a swelling on the right side of the mandible. Radiographically, a well-defined radiolucent area surrounded by radiopaque material was observed. An incisional biopsy was performed and microscopic analysis showed a cystic lesion consisting of an atrophic epithelium comprising 2-3 cell layers and the absence of inflammation in the cystic capsule. The cyst was decompressed and the lesion was removed after 3 months of follow-up. Microscopic analysis of the surgical specimen showed a cystic hyperplastic epithelium surrounded by an intense chronic inflammatory cell infiltrate, which was in close contact with mineralized tissue resembling dentin and cementum. The final diagnosis was cystic odontoma. Since chemotherapy can affect the growth and development of infant teeth, a relationship between chemotherapy-associated adverse events and cystic odontoma is suggested in the present case.

  11. [Prevention of the eruption of an upper later incisor by a compound odontoma. Case report].

    Science.gov (United States)

    Vlcek, Daniel; Reichart, Peter A; Bosshardt, Dieter D; Sleiter, Roberto; Bornstein, Michael M

    2012-01-01

    Odontomas are the most common odontogenic tumours. They are considered as hamartomas - a local tissue malformation without autonomous growth potential - and are non-neoplastic. Clinically and histopathologically, compound and complex odontomas can be differentiated. Compound odontomas consist of a varying number of tooth-like structures and histology show dental tissues in an orderly pattern. Most often compound odontomas are diagnosed in young patients in the anterior maxilla. Patients are rarely complaining of symptoms and they are usually diagnosed during routine radiographic examinations or due to late eruption of permanent or persistence of deciduous teeth. The following case report presents a disturbed eruption of a lateral right incisor of the maxilla in a 8-year old female patient. Clinical, radiological and histopathological characteristics of this lesion will be discussed as well as therapy and follow-up.

  12. An erupted odontoma associated with pigmentation: a histogenetic and histological perspective.

    Science.gov (United States)

    Kaur, Gurkiran A; Sivapathasundharam, B; Berkovitz, Barry K; Radhakrishnan, Raghu A

    2012-01-01

    Odontomas are hamartomatous malformations of odontogenic origin composed of all the structures that form the tooth. Pigmentation associated with odontomas is rare, with only two cases reported in the literature. The genesis of this composite malformation is attributable to the organizational failure of the developing odontogenic apparatus leading to abnormal morphodifferentiation. Although some odontomas erupt into the oral cavity, it defies the existing views of normal physiologic tooth movement thus raising questions over the use of this term. Here, we review a case of large odontoma in a 23-year-old male surfacing into the oral cavity from its intraosseous location. The unusual occurrence of melanotic pigmentation in the odontogenic epithelial rests was demonstrated by Mason Fontana special stain. The histogenesis of this unusual entity and explanation to its possible occurrence is discussed.

  13. An erupted odontoma associated with pigmentation: A histogenetic and histological perspective

    Directory of Open Access Journals (Sweden)

    Gurkiran A Kaur

    2012-01-01

    Full Text Available Odontomas are hamartomatous malformations of odontogenic origin composed of all the structures that form the tooth. Pigmentation associated with odontomas is rare, with only two cases reported in the literature. The genesis of this composite malformation is attributable to the organizational failure of the developing odontogenic apparatus leading to abnormal morphodifferentiation. Although some odontomas erupt into the oral cavity, it defies the existing views of normal physiologic tooth movement thus raising questions over the use of this term. Here, we review a case of large odontoma in a 23-year-old male surfacing into the oral cavity from its intraosseous location. The unusual occurrence of melanotic pigmentation in the odontogenic epithelial rests was demonstrated by Mason Fontana special stain. The histogenesis of this unusual entity and explanation to its possible occurrence is discussed.

  14. Multiple macrodonts with odontoma in a mother and son--a variant of Ekman-Westborg-Julin syndrome. Report of a case.

    Science.gov (United States)

    Yoda, T; Ishii, Y; Honma, Y; Sakai, E; Enomoto, S

    1998-03-01

    A case of multiple macrodonts with a complex odontoma in a mother and son is reported. This condition is thought to represent a variant of the Ekman-Westborg-Julin syndrome. The authors discuss the relationship between macrodontia and odontoma, and the involvement of hereditary factors is suggested.

  15. A retrospective analysis of the characteristics, treatment and follow-up of 26 odontomas in Greek children.

    Science.gov (United States)

    Iatrou, Ioannis; Vardas, Emmanouil; Theologie-Lygidakis, Nadia; Leventis, Minas

    2010-09-01

    Odontomas represent the most common type of odontogenic jaw tumors among patients younger than 20 years of age. Clinically, they are often associated with eruption failure of adjacent permanent teeth, and are classified as compound and complex. The aim of the present retrospective study was to present the characteristics, treatment approach and outcome of odontomas in Greek children, over a ten-year period. Twenty six patients, 2 to 14 years of age (mean 9.3 years), with odontomas treated during the years 1999-2008 at the Department of Oral & Maxillofacial Surgery of a Children's Hospital, were included in the study. Data from patients' files were retrieved and they were recalled for review. Odontomas were equally distributed in the maxilla and mandible and 42.3% of them were located in the anterior maxilla. Of the odontomas, 80.7% were related to disturbances in tooth eruption. Bone expansion was observed in 65.3% of the cases. All odontomas were surgically removed, and related impacted permanent teeth were either left to erupt spontaneously, orthodontically guided into occlusion or were removed. Orthodontic intervention appeared to be necessary in older children, while in younger children spontaneous eruption was frequent. In the present study, odontomas were associated with unerupted or impacted teeth. Radiographic examination was essential to verify the presence of the tumor and early removal prevented tooth eruption failure and disturbances in a majority of the cases.

  16. Importance of cone beam computed tomography for diagnosis of calcifying cystic odontogenic tumour associated to odontoma. Report of a case.

    Science.gov (United States)

    Marques, Yonara-Maria-Freire-Soares; Botelho, Tessa-de Lucena; Xavier, Flávia-Caló-de Aquino; Rangel, Andrea-Leão; Rege, Inara-Carneiro-Costa; Mantesso, Andrea

    2010-05-01

    The calcifying cystic odontogenic tumour (CCOT) is a rare benign cystic neoplasm not infrequently associated with odontoma. This report documents a case of CCOT associated with compound odontoma arising in the anterior maxilla in a 25-year-old woman. Conventional radiographs showed a large calcified mass with poorly visualized radiolucent margins. The extent and condition of the internal structure of the CCOT associated with odontoma was able to be determined based on radiographic findings from cone beam computed tomography. This advanced image technique proved to be extremely useful in the radiographic assessment of this particular neoplasm of the jawbones.

  17. A CASE OF COMPOUND MAXILLARY ODONTOMA AND MANDIBULAR HYPODONTIA

    Directory of Open Access Journals (Sweden)

    Radka Cholakova

    2016-07-01

    Full Text Available Odontomas are formations which are still classified as benign tumors by the World Health Organization. They are lesions on any odontogenic tissue – enamel, cement and dentin, which are affected in different proportions and degree. We present a case of compound odontoma on upper jaw, on a 15 year-old girl, causing retention of a permanent canine tooth. After the extirpation 16 tooth-like structures were uncovered. The mandible was diagnosed with hypodontia of both 2nd premolars. Patient’s history showed that there was a trauma in the area of the upper jaw at younger age. In this article we will present the clinical and radiographic examination, the stages of the complex surgical-orthodontic treatment and a discussion of the etiology of the diagnosis, complications and the treatment itself.

  18. Ameloblastic fibro-odontoma: a case report.

    Science.gov (United States)

    Cavalcante, Ana-Sueli-Rodrigues; Anbinder, Ana-Lia; Costa, Nívea-Cristina-Sena; Lima, José-Roberto Sá; Carvalho, Yasmin-Rodarte

    2009-12-01

    Ameloblastic fibro-odontoma (AFO) is a rare, benign, slow-growing odontogenic tumor, generally asymptomatic and more prevalent in children and adolescents. We report a case of AFO in the mandible of an eight-year-old Caucasian male patient, and review the literature . Intraoral examination revealed a swelling extending from the deciduous second molar to the retromolar triangle, covered with normal mucosa. A panoramic radiograph showed a large, well-demarcated radiolucency with radiopaque areas. The provisional diagnosis was of AFO, and so an incisional biopsy was performed. Histologically, the lesion was composed of connective tissue resembling the dental papilla, with epithelial strands or islands, as well as denticles and amorphous masses of enamel and dentin consistent with a diagnosis of AFO. Surgical excision and curettage of the lesion were performed. The patient has been monitored for eight years and the lesion has not recurred.

  19. An unusual size of ameloblastic fibro-odontoma.

    Science.gov (United States)

    Dolanmaz, D; Pampu, A A; Kalayci, A; Etöz, O A; Atici, S

    2008-03-01

    Ameloblastic fibro-odontoma (AFO) is a quite rare, mixed odontogenic tumour generally seen in the early stages of life. Frequent signs of the tumour are asymptomatic swelling, delayed tooth eruption and mixed radiological appearance within well-defined borders. Management of the lesion includes enucleation of the tumour and long-term follow-up in order to avoid recurrence. A 9-year-old girl was referred to our clinic with swelling in her right cheek. After clinical and radiographic examination, a large lobular radiopaque mass with a radiolucent border covering the complete right maxillary sinus was observed. Under general anaesthesia, the lobules of the lesion were enucleated and the permanent right lateral incisor and canine teeth were left for eruption. Histological assessment revealed a final diagnosis of ameloblastic fibro-odontoma. Post-operative healing was uneventful and the remaining teeth erupted normally. No recurrence was observed during the 3 years' follow-up period.

  20. Removal of an extensive mandibular odontoma using an intraoral approach.

    Science.gov (United States)

    Lehman, Hadas; Lustmann, Joshua; Regev, Eran

    2013-01-01

    Odontomas, the most common odontogenic tumors, occur more frequently in the maxilla and are rarely larger than a tooth. They are usually found incidentally on routine dental radiographs during the second decade of life. The treatment of choice is surgical removal, and large tumors are challenging as damage may occur to surrounding anatomic structures. In this article we describe a "giant" compound odontoma occupying the entire body of the mandible and ramus in a 7-year-old girl. A conservative intraoral enucleation was used to avoid facial scarring and preserve mandibular continuity and function. The huge bony defect healed completely without a bone graft or further intervention. This case report emphasizes the importance of the early diagnosis of these lesions and a conservative surgical approach as well as the extraordinary healing potential of young patients.

  1. Ameloblastic fibro-odontoma: a conservative surgical approach.

    Science.gov (United States)

    Nascimento, Jairo-Evangelista; Araújo, Leonardo-de Jesus; Almeida, Luciana-Yamamoto de; De Paula, Alfredo-Maurício; Bonan, Paulo-Rogério

    2009-12-01

    Ameloblastic fibro-odontoma (AFO) is a rare benign mixed odontogenic tumor that occurs predominantly in children and young adults with no gender predilection and anatomic site, usually appearing as a painless swelling. We present a case of an 11-year-old non-Caucasian boy complaining of large painless isolated swelling in the right mandibular body. Intraoral examination revealed a tumoral mass with cortical bone expansion, covered by normal mucosa measuring 4.0 x 2.0 cm, located on both the lingual and buccal surfaces of the right body of the mandible, with displacement of the neighboring teeth. Panoramic radiography revealed an expansile, radiolucent and well circumscribed lesion with scattered foci of calcified material, which contained several radiopaque bodies of varying sizes and shapes. The provisional diagnoses were odontoma or AFO/ Biopsy confirmed AFO. The patient was treated with conservative surgery. After two years of follow-up, no alteration or recurrence was detected.

  2. Differentiation and regenerative capacities of human odontoma-derived mesenchymal cells.

    Science.gov (United States)

    Song, Jin-Seon; Stefanik, Derek; Damek-Poprawa, Monika; Alawi, Faizan; Akintoye, Sunday O

    2009-01-01

    Regenerating human tooth ex vivo and biological repair of dental caries are hampered by non-viable odontogenic stem cells that can regenerate different tooth components. Odontoma is a developmental dental anomaly that may contain putative post-natal stem cells with the ability to differentiate and regenerate in vivo new dental structures that may include enamel, dentin, cementum and pulp tissues. We evaluated odontoma tissues from 14 patients and further isolated and characterized human odontoma-derived mesenchymal cells (HODCs) with neural stem cell and hard tissue regenerative properties from a group of complex odontoma tissues from 1 of 14 patients. Complex odontoma was more common (9 of 14) than compound type and females (9 of 14) were more affected than males in our set of patients. HODCs were highly proliferative like dental pulp stem cells (DPSCs) but demonstrated stronger neural immunophenotype than both DPSCs and mandible bone marrow stromal cells (BMSCs) by expressing higher levels of nestin, Sox 2 and betaIII-tubulin. When transplanted with hydroxyapatite/tricalcium phosphate into immunocompromised mice, HODCs differentiated and regenerated calcified hard tissues in vivo that were morphologically and quantitatively comparable to those generated by DPSCs and BMSCs. When transplanted with polycaprolactone (biodegradable carrier), HODCs differentiated to form new predentin on the surface of a dentin platform. Newly formed predentin contained numerous distinct dentinal tubules and an apparent dentin-pulp arrangement. HODCs represent unique odontogenic progenitors that readily commit to formation of dental hard tissues.

  3. An Erupted Dilated Odontoma: A Rare Presentation

    Directory of Open Access Journals (Sweden)

    Gaurav Sharma

    2016-01-01

    Full Text Available A dilated odontoma is an extremely rare developmental anomaly represented as a dilatation of the crown and root as a consequence of a deep, enamel-lined invagination and is considered a severe variant of dens invaginatus. An oval shape of the tooth lacking morphological characteristics of a crown or root implies that the invagination happened in the initial stages of morphodifferentiation. Spontaneous eruption of an odontoma is a rare occurrence and the occurrence of a dilated odontoma in a supernumerary tooth is even rarer with only a few case reports documented in the English literature. We present an extremely rare case of erupted dilated odontoma occurring in the supernumerary tooth in anterior maxillary region in an 18-year-old male, which, to the best of our knowledge, is the first ever case reported in English literature.

  4. An Erupted Dilated Odontoma: A Rare Presentation

    Science.gov (United States)

    Sharma, Gaurav; Nagra, Amritpreet; Singh, Gurkeerat; Nagpal, Archna; Soin, Atul; Bhardwaj, Vishal

    2016-01-01

    A dilated odontoma is an extremely rare developmental anomaly represented as a dilatation of the crown and root as a consequence of a deep, enamel-lined invagination and is considered a severe variant of dens invaginatus. An oval shape of the tooth lacking morphological characteristics of a crown or root implies that the invagination happened in the initial stages of morphodifferentiation. Spontaneous eruption of an odontoma is a rare occurrence and the occurrence of a dilated odontoma in a supernumerary tooth is even rarer with only a few case reports documented in the English literature. We present an extremely rare case of erupted dilated odontoma occurring in the supernumerary tooth in anterior maxillary region in an 18-year-old male, which, to the best of our knowledge, is the first ever case reported in English literature. PMID:26989523

  5. An Erupted Dilated Odontoma: A Rare Presentation.

    Science.gov (United States)

    Sharma, Gaurav; Nagra, Amritpreet; Singh, Gurkeerat; Nagpal, Archna; Soin, Atul; Bhardwaj, Vishal

    2016-01-01

    A dilated odontoma is an extremely rare developmental anomaly represented as a dilatation of the crown and root as a consequence of a deep, enamel-lined invagination and is considered a severe variant of dens invaginatus. An oval shape of the tooth lacking morphological characteristics of a crown or root implies that the invagination happened in the initial stages of morphodifferentiation. Spontaneous eruption of an odontoma is a rare occurrence and the occurrence of a dilated odontoma in a supernumerary tooth is even rarer with only a few case reports documented in the English literature. We present an extremely rare case of erupted dilated odontoma occurring in the supernumerary tooth in anterior maxillary region in an 18-year-old male, which, to the best of our knowledge, is the first ever case reported in English literature.

  6. Odontoma-associated tooth impaction: accurate diagnosis with simple methods? Case report and literature review.

    Science.gov (United States)

    Troeltzsch, Matthias; Liedtke, Jan; Troeltzsch, Volker; Frankenberger, Roland; Steiner, Timm; Troeltzsch, Markus

    2012-10-01

    Odontomas account for the largest fraction of odontogenic tumors and are frequent causes of tooth impaction. A case of a 13-year-old female patient with an odontoma-associated impaction of a mandibular molar is presented with a review of the literature. Preoperative planning involved simple and convenient methods such as clinical examination and panoramic radiography, which led to a diagnosis of complex odontoma and warranted surgical removal. The clinical diagnosis was confirmed histologically. Multidisciplinary consultation may enable the clinician to find the accurate diagnosis and appropriate therapy based on the clinical and radiographic appearance. Modern radiologic methods such as cone-beam computed tomography or computed tomography should be applied only for special cases, to decrease radiation.

  7. Management of a Compound Odontoma in the Primary Dentition.

    Science.gov (United States)

    Altay, Mehmet Ali; Ozgur, Beste; Cehreli, Zafer C

    2016-01-01

    Odontomas are the most common benign odontogenic tumors of the oral cavity; however, their occurrence in the primary dentition is an extremely rare condition. When associated with primary teeth, odontomas may lead to disturbances in tooth eruption, which often requires a multidisciplinary treatment approach. The purpose of this paper is to review the literature on odontomas of the primary dentition and discuss the management of a compound odontoma in a pediatric patient.

  8. Compound Odontoma: Differential Diagnosis and Review of the Literature.

    Science.gov (United States)

    Gedik, R; Müftüoğlu, S

    2014-12-01

    Odontomas are the most common odontogenic tumours. They are usually asymptomatic and are often discovered during routine radiography. Compound odontomas are regularly calcified tissue that bear similarity to teeth or appear as a collection of small teeth. We report a rare case of compound odontoma in the mandible of an adult patient with clinical and radiological features and a review of the literature.

  9. An Odontoma Found in the Wake of Maxillary Sinusitis Onset

    OpenAIRE

    2013-01-01

    Sinusitis of dental origin is a relatively frequent entity, and odontomas are considered to be the most common odontogenic tumors of the oral cavity. Eruption and infection of odontomas are extremely rare. Here, we report an interesting case where odontoma was found in the wake of the maxillary sinusitis onset.

  10. Ameloblastic fibro-odontoma. Case report and review of the literature.

    Science.gov (United States)

    De Riu, Giacomo; Meloni, Silvio Mario; Contini, Marcella; Tullio, Antonio

    2010-03-01

    Ameloblastic fibro-odontoma (AFO) is defined by the World Health Organization (WHO) as a neoplasm composed of proliferating odontogenic epithelium. It is a benign, slow-growing, expansive tumour that clinically appears as a well-encapsulated, benign lesion. Histologically, AFO has been classified as an ameloblastic fibroma or odontoma. Despite numerous efforts, however, there is still considerable confusion concerning the nature, the histology and the therapy of these lesions. This paper reports an additional case of a large AFO and reviews the relevant literature regarding the clinical and pathologic features of this lesion.

  11. Pigmented ameloblastic fibro-odontoma: clinical, histological, and immunohistochemical profile.

    Science.gov (United States)

    Martínez Martínez, Marisol; Romero, Celeste Sánchez; Piña, Alicia Rumayor; Palma Guzmán, José Mario; de Almeida, Oslei Paes

    2015-02-01

    Ameloblastic fibro-odontoma (AFO) is a slow-growing, expansive, benign odontogenic tumor, composed of ameloblastic epithelium embedded in an ectomesenchymal stroma resembling dental papilla, containing hard dental tissue in variable degrees of maturation, including enamel, dentin, and sometimes cementum. AFO typically affects the posterior mandible, causing bony expansion. We report a case of pigmented AFO in a 5-year-old boy, comprising clinical and histological features illustrated by immunohistochemistry using a large panel of antibodies, polarized light microscopy and scanning electron microscopy.

  12. Multiple compound odontomas in mandible: A rarity

    Directory of Open Access Journals (Sweden)

    Sanjeev Vaid

    2012-01-01

    Full Text Available Odontomas are benign odontogenic tumors composed of enamel, dentine, and cementum and pulp tissue. They are usually clinically asymptomatic, but often associated with tooth eruption disturbances. The present study reports an unusual case of eleven odontomas in the left lateral incisor-canine region of lower jaw. A 26 years old female presented to the department of orthodontics and dentofacial orthopedics in H.P. Govt. Dental College and Hospital Shimla for the treatment of misaligned teeth. Clinical examination revealed that the lower left lateral incisor was missing. Patient was advised for radiographs, which revealed a mixed radiopaque lesion associated to impacted lower left canine. The histological report in this case indicated a compound odontoma.

  13. Compound odontoma associated with impacted maxillary incisors

    Directory of Open Access Journals (Sweden)

    S Sreedharan

    2012-01-01

    Full Text Available Odontomas are considered to be the most common odontogenic tumors of the oral cavity. Some authors consider it as malformations rather than true neoplasms. The exact etiology of odontomes is still not known. Most odontomes are asymptomatic and are discovered during routine radiographic investigations. Odontomes generally cause disturbances in the eruption of the teeth, most commonly delayed eruption or deflection. The present report describes the surgical management of a case of compound odontoma in a 10-year-old boy who presented with a complaint of swelling in the maxillary right anterior region and retained deciduous incisors. The related literature is also being reviewed in this article.

  14. Compound odontoma associated with impacted maxillary incisors.

    Science.gov (United States)

    Sreedharan, S; Krishnan, I S

    2012-01-01

    Odontomas are considered to be the most common odontogenic tumors of the oral cavity. Some authors consider it as malformations rather than true neoplasms. The exact etiology of odontomes is still not known. Most odontomes are asymptomatic and are discovered during routine radiographic investigations. Odontomes generally cause disturbances in the eruption of the teeth, most commonly delayed eruption or deflection. The present report describes the surgical management of a case of compound odontoma in a 10-year-old boy who presented with a complaint of swelling in the maxillary right anterior region and retained deciduous incisors. The related literature is also being reviewed in this article.

  15. Ameloblastic Fibro-Odontoma in a 4-Year-Old Boy

    Directory of Open Access Journals (Sweden)

    Mehdi Ghandehari-Motlagh

    2016-03-01

    Full Text Available Introduction Ameloblastic fibro-odontoma (AFO is defined as a benign odontogenic tumor with slow growing behavior. Its prevalence is rare. AFO is characterized by histologic features of ameloblastic fibroma (AF with the formation of enamel and dentine. Case Presentation This is a case report of AFO accompanied with a number of impacted deciduous teeth and its management in a 4-year old boy. Examination of oral cavity revealed an extensive swelling from midline to left deciduous maxillary first molar, covered with normal mucosa. Radiographic examination showed a well-defined mixed radiolucent-radiopaque lesion that extended horizontally from midline to mesial border of the left maxillary primary first molar and vertically from alveolar crest to the floor of nose. The differential diagnosis was odontoma (ameloblastic fibro-odontoma, complex odontoma. Surgical enucleation and curettage was performed under general anesthesia. Histopathologic sections show bone trabeculae in marrow spaces. There was myxoid matrix in some spaces which contained odontogenic epithelial cells. These findings led to diagnosis of AFO. No sign of recurrence has been observed during the 12-month follow-up period. Conclusion Although AFO is a rare tumor, it is more prevalent in childrenʼs jaw. Conservative surgical treatment allowed the normal development of teeth.

  16. Ameloblastic Fibro-Odontoma in a 4-Year-Old Boy.

    Science.gov (United States)

    Ghandehari-Motlagh, Mehdi; Khosravi, Zahra; Meighani, Ghasem; Baradaran-Nakhjavani, Yahya

    2016-04-01

    Ameloblastic fibro-odontoma (AFO) is defined as a benign odontogenic tumor with slow growing behavior. Its prevalence is rare. AFO is characterized by histologic features of ameloblastic fibroma (AF) with the formation of enamel and dentine. This is a case report of AFO accompanied with a number of impacted deciduous teeth and its management in a 4-year old boy. Examination of oral cavity revealed an extensive swelling from midline to left deciduous maxillary first molar, covered with normal mucosa. Radiographic examination showed a well-defined mixed radiolucent-radiopaque lesion that extended horizontally from midline to mesial border of the left maxillary primary first molar and vertically from alveolar crest to the floor of nose. The differential diagnosis was odontoma (ameloblastic fibro-odontoma, complex odontoma). Surgical enucleation and curettage was performed under general anesthesia. Histopathologic sections show bone trabeculae in marrow spaces. There was myxoid matrix in some spaces which contained odontogenic epithelial cells. These findings led to diagnosis of AFO. No sign of recurrence has been observed during the 12-month follow-up period. Although AFO is a rare tumor, it is more prevalent in children's jaw. Conservative surgical treatment allowed the normal development of teeth.

  17. Pyogenic granuloma associated with mandibular odontoma.

    Directory of Open Access Journals (Sweden)

    Karla Ocampo

    2014-08-01

    Full Text Available Background: pyogenic granuloma is a kind of inflammatory hyperplasia of multifactorial origin, which is usually related to trauma or constant irritation, drug use, hormonal factors, among others. Meanwhile the odontoma is a benign tumor odontogenic composed of epithelial and mesenchymal cells, their development is usually associated with trauma, infections, inherited disorders or hyperactivity odontoblast. Objectives: The objective is to present the clinical case of a patient that presented a case of pyogenic granuloma related to the presence of a mandibular odontoma, and therapeutic management and postoperative results. Case report: The case shows a female patient of 32 years old with a history of multinodular goiter and hypothyroidism, developing a mandibular odontoma of the left side associated with pyogenic granuloma in the same area, which was treated with surgical excision and reconstructed affected tissues with lyophilized bone and collagen membrane. Favorable outcome after surgery without evidence of recurrence, with proper osseointegration of alloplastic materials and soft tissues. Conclusions: The irritant effect of the presence of a tumor (odontoma in developing confirmed pyogenic granuloma.

  18. Erupted odontomas: a report of two unusual cases

    Directory of Open Access Journals (Sweden)

    Santosh Patil

    2012-06-01

    Full Text Available ntroduction: Odontomas are the most common odontogenic tumors of the jaws which are benign, slow growing and nonaggressive. They are usually asymptomatic and are diagnosed on routine radiological examination. The eruptions of odontomas are uncommon and very few cases are reported in the literature. Objective: To report two rare cases of erupted compound odontomas. Case report: Two cases of erupted compound odontomas are reported in middle aged patients. Erupted miniature teeth-like structure were seen on clinical examination. The condition was diagnosed on the basis of conventional intraoral radiographs and histopathological examination. Both cases were treated by surgical excision under local anaesthesia without any complications. Conclusion: Odontomas are benign tumors with uncertain etiology. Odontomas erupting in the oral cavity is an infrequent situation. Surgical excision is the treatment of choice in all such cases followed by histopathological examination to confirm the clinical diagnosis.

  19. Compound Odontoma: Differential Diagnosis and Review of the Literature

    Science.gov (United States)

    Gedik, R; Müftüoğlu, S

    2014-01-01

    ABSTRACT Odontomas are the most common odontogenic tumours. They are usually asymptomatic and are often discovered during routine radiography. Compound odontomas are regularly calcified tissue that bear similarity to teeth or appear as a collection of small teeth. We report a rare case of compound odontoma in the mandible of an adult patient with clinical and radiological features and a review of the literature. PMID:25867569

  20. Odontomas: Review Of Literature And Report Of A Case

    Directory of Open Access Journals (Sweden)

    Sumeeta Kaswan

    2012-01-01

    Full Text Available Odontomas are the most common of the odontogenic tumors of the jaws, which are benign, slow growing and nonaggressive. Odontomas are usually asymptomatic but sometimes may interfere with the eruption of the associated tooth leading to impaction or delayed eruption. These lesions are usually diagnosed on routine radiological examination in the second decade of the life. The aim of this paper is to present a thorough review on the etiology, clinical presentation, histopathological features and treatment aspects of odontomas. A case of compound odontoma has been reported along with.

  1. A massive ameloblastic fibro-odontoma of the maxilla.

    Science.gov (United States)

    Hegde, Veda; Hemavathy, S

    2008-01-01

    Ameloblastic fibro-odontoma is a rare, benign mixed odontogenic tumor. It occurs exclusively as an intraosseous lesion. It usually has a slow growth and is seen in children and young adults. A painless swelling is the most common clinical sign. Radiographically, ameloblastic fibro-odontoma appears as a circumscribed radiolucency which may contain radiopaque foci. Most cases of ameloblastic fibro-odontoma exhibit benign behavior, but cases of malignant transformation have been reported. The treatment modality in most cases involves conservative surgery, but cases with malignant transformation will require more radical treatment. A massive ameloblastic fibro-odontoma involving the maxilla has been described here with its clinical, radiological, and histopathological features.

  2. Impacted permanent incisors associated with compound odontoma.

    Science.gov (United States)

    Machado, Cintia de Vasconcellos; Knop, Luégya Amorin Henriques; da Rocha, Maria Celina Barreiros Siquara; Telles, Paloma Dias da Silva

    2015-01-12

    Odontomas are the most common odontogenic tumours of the maxillary bones, characterised by a slow growth and benign behaviour. They are usually small, asymptomatic and diagnosed after routine radiographic examination. The aim of this study was to report a case of a compound odontoma in the anterior maxilla of a 7-year-old girl, which was causing the impaction of the maxillary right central and lateral incisors, as well as the prolonged retention of the corresponding primary teeth. We also aimed to review the literature about these tumours, since they are not part of the dentist's day-to-day clinical practice. The clinical and radiographic features, the diagnosis and treatment of the case were discussed in this work.

  3. Compound Odontoma with an Unusual Appearance: Case Report

    Directory of Open Access Journals (Sweden)

    Mahdi Niknami

    2016-10-01

    Full Text Available The term odontoma is used to identify a tumor that is characterized by the production of mature enamel, dentin, cementum and pulp tissue and may interfere with the eruption of the associated tooth. The present report describes an odontoma in a 13-year-old boy, which is associated with an impacted tooth through a canal

  4. [Compound odontoma as a cause of chronic maxillary sinusitis].

    Science.gov (United States)

    Crespo Del Hierro, Jorge; Ruiz González, Manuel; Delgado Portela, Margarita; García Del Castillo, Eduardo; Crespo Serrano, Juan

    2008-01-01

    Sinusitis of dental origin is a relatively frequent entity, but the presence of an odontoma in the sinus as a source of this pathology is exceptional. Here we present a case of a young patient who presented chronic maxillary sinusitis over 2 years, originating in an odontoma located in the sinus drainage area.

  5. Reliability of large and complex systems

    CERN Document Server

    Kolowrocki, Krzysztof

    2014-01-01

    Reliability of Large and Complex Systems, previously titled Reliability of Large Systems, is an innovative guide to the current state and reliability of large and complex systems. In addition to revised and updated content on the complexity and safety of large and complex mechanisms, this new edition looks at the reliability of nanosystems, a key research topic in nanotechnology science. The author discusses the importance of safety investigation of critical infrastructures that have aged or have been exposed to varying operational conditions. This reference provides an asympt

  6. Odontomas--silent tormentors of teeth eruption, shedding and occlusion.

    Science.gov (United States)

    Kulkarni, Vinaya Kumar; Deshmukh, Jeevanand; Banda, Naveen Reddy; Banda, Vanaja Reddy

    2012-12-14

    Odontomas are the most common odontogenic tumours of the jaws, characterised by their slow growth and non-aggressive behaviour. They usually remain asymptomatic, and are diagnosed on routine radiographs. Clinically, they are often associated with delayed eruption or impaction of permanent teeth and retained primary teeth. The purpose of this paper is to review the literature and report two cases of odontomas. In the first case, a compound odontoma was associated with an unerupted maxillary permanent right central incisor, in an 11-year-old boy. In the second case, a 12-year-old girl had retained mandibular primary left central incisor and its unerupted successor was associated with a compound odontoma, a site considered rare for compound odontoma to occur. The clinical features, diagnosis and treatment of these cases have been discussed.

  7. Malignant transformation of ameloblastic fibro-odontoma to ameloblastic fibrosarcoma.

    Science.gov (United States)

    Howell, R M; Burkes, E J

    1977-03-01

    Two cases of malignant transformation of ameloblastic fibro-odontomas are presented, along with a review of the literature on ameloblastic fibrosarcomas. The occurrence of this malignant transformation of ameloblastic fibromas, ameloblastic odontomas, and ameloblastic fibro-odontomas appears to be more frequent than previously thought. This potential transformation alone does not justify radical treatment of all these benign lesions. If there is recurrence accompanied by a histologic pattern change toward a more unorganized fibrous stroma with displacement of the epithelial component, however, then more extensive treatment procedures appear to be indicated.

  8. Ameloblastic fibro-odontoma in children: report of 2 cases.

    Science.gov (United States)

    Santos, Thiago de Santana; de Carvalho, Ricardo Wathson Feitosa; Avelar, Rafael Linard; Dias de Oliveira e Silva, Emanuel; Frota, Riedel; Anjos, Edvaldo Dória

    2011-01-01

    Ameloblastic fibro-odontoma is a rare, mixed, benign, odontogenic tumor of significant prevalence in the mandible, with epithelial and mesenchymal components. It usually affects pediatric patients and is associated with teeth, causing a delay in eruption chronology or an alteration in the dental eruption pathway. It is occasionally diagnosed during radiographic evaluations of these patients. The literature is unclear whether it is a distinct pathological entity or a stage of odontoma. As it is benign and has a low recurrence rate, conservative treatment is recommended. The purpose of this paper was to present 2 cases of ameloblastic fibro-odontoma in the mandibles of children.

  9. Fibro-odontoma ameloblástico de la mandíbula Ameloblastic fibro-odontoma of the jaw

    Directory of Open Access Journals (Sweden)

    María Loreto Castellón

    2013-06-01

    Full Text Available El fibro-odontoma ameloblástico (FOA es un tumor odontogénico poco frecuente que afecta a personas jóvenes, sin predilección por género y usualmente se localiza en la zona posterior de la mandíbula. Clínicamente el paciente puede presentar retraso en la erupción dentaria acompañado de aumento de volumen indoloro. Radiográficamente es una lesión radiolúcida uni o multilocular de tamaño variable con áreas radiopacas. El tratamiento varía de acuerdo a su tamaño y se debe tener especial cuidado en la decisión de conservar o no los dientes adyacentes, ya que existe la posibilidad de recurrencia de la lesión. Presentamos un caso de FOA de gran tamaño en un paciente de 4 años. Se describen las características específicas, histológicas y clínicas. Se discute en la conducta terapéutica conservadora y la necesidad de control postoperatorio prolongado en el tiempo.Ameloblastic fibro-odontoma (AFO is an infrequent odontogenic tumor that affects young people of either sex and is usually located in the posterior mandibular zone. Clinically, the patient might present a delay in dental eruption with a painless increase in volume. Radiographically, it is a uni- or multilocular radiolucent lesion of variable size with radiopaque areas. Treatment varies with tumor size and the decision to conserve the adjacent teeth must be weighed carefully due to the possibility of recurrence. The case of a large AFO in a 4-year-old patient is reported. The specific histological and clinical characteristics are described and the conservative therapy and need for long-term postoperative follow-up are discussed.

  10. Ameloblastic fibro-odontoma: A diagnostic challenge

    Directory of Open Access Journals (Sweden)

    Abhijeet Alok

    2015-01-01

    Full Text Available Ameloblastic fibro-odontoma (AFO is a rare mixed odontogenic tumor. It occurs predominantly in children and young adults with no sex predilection, mostly in the mandible posterior region. A painless swelling is the most common clinical sign of AFO. Radiographically, AFO shows a circumscribed radiolucency, which contains radiopaque foci of various sizes and shapes. Histological examination reveals a fibrous soft tissue, islands of odontogenic epithelium, and a disordered mixture of dental tissues. Treatment of AFOs usually consists of enucleation or surgical curettage, which is possible due to their benign biological behavior. Here, we are reporting a case of AFO in a 20-year-old male.

  11. Large-scale Complex IT Systems

    CERN Document Server

    Sommerville, Ian; Calinescu, Radu; Keen, Justin; Kelly, Tim; Kwiatkowska, Marta; McDermid, John; Paige, Richard

    2011-01-01

    This paper explores the issues around the construction of large-scale complex systems which are built as 'systems of systems' and suggests that there are fundamental reasons, derived from the inherent complexity in these systems, why our current software engineering methods and techniques cannot be scaled up to cope with the engineering challenges of constructing such systems. It then goes on to propose a research and education agenda for software engineering that identifies the major challenges and issues in the development of large-scale complex, software-intensive systems. Central to this is the notion that we cannot separate software from the socio-technical environment in which it is used.

  12. A massive ameloblastic fibro-odontoma of the maxilla

    Directory of Open Access Journals (Sweden)

    Hegde Veda

    2008-01-01

    Full Text Available Ameloblastic fibro-odontoma is a rare, benign mixed odontogenic tumor. It occurs exclusively as an intraosseous lesion. It usually has a slow growth and is seen in children and young adults. A painless swelling is the most common clinical sign. Radiographically, ameloblastic fibro-odontoma appears as a circumscribed radiolucency which may contain radiopaque foci. Most cases of ameloblastic fibro-odontoma exhibit benign behavior, but cases of malignant transformation have been reported. The treatment modality in most cases involves conservative surgery, but cases with malignant transformation will require more radical treatment. A massive ameloblastic fibro-odontoma involving the maxilla has been described here with its clinical, radiological, and histopathological features.

  13. An unusual triad: Bilateral dilated odontoma, hypodontia and peg laterals.

    Science.gov (United States)

    Sebastian, Alphy Alphonsa; Ahsan, Auswaf; George, Ahkin John; Aby, John

    2013-09-01

    The dilated odontoma is an infrequent developmental alteration that appears in any area of the dental arches and can affect deciduous, permanent and supernumerary tooth. Dens invaginatus is a developmental anomaly resulting from invagination of a portion of crown forming within the enamel organ during odontogenesis. The most extreme form of dens invaginatus is known as dilated odontoma. The aim of this case report is to present a rare case of bilateral dilated odontoma affecting a microdontic permanent lateral incisor in a 30 year old female patient with hypodontia and peglateral teeth with its clinical, radiological and histological features, which has yet been not reported. Bilateral presence of dilated odontoma is not a common occurrence, although a single tooth involvement in each case has been reported in the literature.

  14. Extensive Mandibular Ameloblastic Fibro-Odontoma.

    Science.gov (United States)

    Ribeiro, Cínthia Magalhães; Santos, Tatiana Tavares Marcelino Dos; de Castro, Sérgio Roberto; de Carli, Marina Lara; Sperandio, Felipe Fornias; Hanemann, João Adolfo Costa; Pereira, Alessandro Antônio Costa

    2016-09-01

    Ameloblastic fibro-odontoma (AFO) is a mixed odontogenic tumor that presents epithelial and mesenchymal components. Ameloblastic fibro-odontoma is generally diagnosed between the first and second decades of life and normally shows a slow clinical growth in the posterior portion of the maxilla or mandible, being mostly associated with 1 or more impacted teeth. Radiographic features of AFO show a radiolucent well-defined, uni, or multilocular defect due to containing variable amounts of calcified material. The enucleation of the tumor is the usual conduct and should be followed up for a long period of time. Here, the authors report the case of 17-year-old male patient who presented an extensive AFO on the right posterior side of the mandible. The panoramic radiograph and the tomographic examination revealed a multilocular radiolucent lesion with impacted teeth. Histological examination revealed connective tissue resembling the dental papilla along with epithelial strands or islands, as well as dental hard tissue such enamel and dentin. Enucleation and curettage was performed and led to good outcome. There was no recurrence after an 8-year follow-up, and oral rehabilitation was performed with dental implants.

  15. An unusual triad: Bilateral dilated odontoma, hypodontia and peg laterals

    Directory of Open Access Journals (Sweden)

    Alphy Alphonsa Sebastian

    2013-01-01

    The aim of this case report is to present a rare case of bilateral dilated odontoma affecting a microdontic permanent lateral incisor in a 30 year old female patient with hypodontia and peglateral teeth with its clinical, radiological and histological features, which has yet been not reported. Bilateral presence of dilated odontoma is not a common occurrence, although a single tooth involvement in each case has been reported in the literature.

  16. Online community detection for large complex networks.

    Directory of Open Access Journals (Sweden)

    Gang Pan

    Full Text Available Complex networks describe a wide range of systems in nature and society. To understand complex networks, it is crucial to investigate their community structure. In this paper, we develop an online community detection algorithm with linear time complexity for large complex networks. Our algorithm processes a network edge by edge in the order that the network is fed to the algorithm. If a new edge is added, it just updates the existing community structure in constant time, and does not need to re-compute the whole network. Therefore, it can efficiently process large networks in real time. Our algorithm optimizes expected modularity instead of modularity at each step to avoid poor performance. The experiments are carried out using 11 public data sets, and are measured by two criteria, modularity and NMI (Normalized Mutual Information. The results show that our algorithm's running time is less than the commonly used Louvain algorithm while it gives competitive performance.

  17. Ameloblastic fibro-odontoma: a case report.

    Science.gov (United States)

    Mummolo, Stefano; Marchetti, Enrico; Di Martino, Salvatore; Scorzetti, Luisa; Marzo, Giuseppe

    2010-04-01

    The clinical case of an unusual ameloblastic fibro-odontoma (AFO) was reported. The patient's clinical chart as well as preoperative and postoperative radiographs and histological findings of a 20-year old man that addressed Dental Clinic at University of L'Aquila were thoroughly reviewed. The patient showed a swelling in the oral cavity and radiographic feature of a radiolucent lesion at left second premolar maxillary site. Histologic examination made diagnosis of AFO. AFO is a rare mixed odontogenic tumor with similarities to the ameloblastic fibroma (AF) and ameloblastic dentinoma. The nature and the relationships between mixed odontogenic tumours and related lesions are still controversial. Moreover is not clear if these lesions are separate pathologies or if they are different development stages of the same pathology.

  18. Visualizing global properties of large complex networks.

    Directory of Open Access Journals (Sweden)

    Weijiang Li

    Full Text Available For complex biological networks, graphical representations are highly desired for understanding some design principles, but few drawing methods are available that capture topological features of a large and highly heterogeneous network, such as a protein interaction network. Here we propose the circular perspective drawing (CPD method to visualize global structures of large complex networks. The presented CPD combines the quasi-continuous search (QCS analogous to the steepest descent method with a random node swapping strategy for an enhanced calculation speed. The CPD depicts a network in an aesthetic manner by showing connection patterns between different parts of the network instead of detailed links between nodes. Global structural features of networks exhibited by CPD provide clues toward a comprehensive understanding of the network organizations.Software is freely available at http://www.cadlive.jp.

  19. Adenomatoid odontogenic tumor associated with odontoma: a case report and critical review of the literature.

    Science.gov (United States)

    Gomez, Ricardo Santiago; Castro, Wagner Henriques; Gomes, Carolina Cavaliéri; Loyola, Adriano Mota

    2013-08-09

    We describe a case of adenomatoid odontogenic tumor (AOT) associated with odontoma occurring in the posterior mandible of a 32-year-old man. Although calcifications are commonly found in the AOT, the presence of rudimentary dental structures is a very rare phenomenon. Cases with similar aspects have been described as ameloblastic dentinoma, ameloblastic odontoma, adenoameloblastic odontoma and AOT associated with odontoma. After a careful analysis of the literature we describe the clinical aspects of this tumor. Further case reports and surveys of odontogenic tumors are necessary to define whether AOT associated with odontoma is a variant of AOT or a distinct clinicopathologic condition.

  20. 与乳牙相关的巨大混合性牙瘤1例%Large complex odontoma associated with a primary tooth

    Institute of Scientific and Technical Information of China (English)

    Llker (O)zec; Erdem Kilic; Hasan Yeler; Fahrettin G(o)ze; Defne Yeler; 谢晓艳

    2008-01-01

    牙瘤是牙组织的发育性畸形,它可干扰相关牙齿的萌出.牙瘤的生长潜力有限,其在乳牙列的发生少见.本文描述1例发生于一个5.2岁男孩的妨碍下颌左侧侧切牙萌出的巨大混合性牙瘤.该牙瘤被手术摘除,进行了1年以上的常规随访,未见复发.

  1. [Compound odontoma with history of trauma: report of a case].

    Science.gov (United States)

    Sámano Iturría, G; Cedeño Pacheco, E

    1988-08-01

    Clinical and roentgenographical features are described for a compound odontoma in a ten-year old male with a history of trauma in the anterior region of the face. Diagnostical methods and surgical handling are discussed, with a review of the pertinent literature.

  2. New Large Diameter RF Complex Plasma Device

    Science.gov (United States)

    Meyer, John; Nosenko, Volodymyr; Thomas, Hubertus

    2016-10-01

    The Complex Plasma Research Group at the German Aerospace Center (DLR) in Oberpfaffenhofen has built a new large diameter rf plasma setup for dusty plasma experiments. The vacuum chamber is a stainless steel cylinder 0.90 m in diameter and 0.34 m in height with ports for viewing and measurement. A 0.85 m diameter plate in about the center serves as a powered electrode (13.56 MHz) with the chamber walls as the ground. It is pumped on by one of two Oerlikon turbo pumps with a pumping rate of 1100 l/s or 270 l/s. Argon gas is admitted into the chamber by an MKS mass flow meter and pumping is regulated by a butterfly valve to set pressure for experiments. A manual dropper is used to insert dust into the plasma. The dust is illuminated horizontally by a 660 nm 100 mW laser sheet and viewed from above by a Photron FASTCAM 1024 PCI camera. A vertical laser sheet of 635 nm will be used for side imaging. So far, single-layer plasma crystals of up to 15000 particles have been suspended. The particle velocity fluctuation spectra were measured and from these, the particle charge and screening length were calculated. Future experiments will explore the system-size dependence of the plasma crystal properties.

  3. Dilated odontoma: A report of two cases from a radiological perspective

    Directory of Open Access Journals (Sweden)

    S Jayachandran

    2016-01-01

    Full Text Available Dilated odontoma is the most extreme form of dens invaginatus. The lesion appears as a roughly spherical mass that does not resemble a tooth but in a way appears tooth - like on radiographs due to somewhat similar radiodensity. The lesion is mostly spherical in appearance and hence the term “dilated.” Occasionally, we come across cases of simultaneous pathologies. Here, we report two cases of a dilated odontoma one of which is associated with dentigerous cyst and in other case dilated odontoma pushing the maxillary sinus superiorly. Histologically, the mass was composed of dentinal tubules. These morphological and histological features are compatible with those of a dilated odontoma.

  4. Compound odontoma associated with an unerupted mandibular primary canine: A case report

    Directory of Open Access Journals (Sweden)

    Seraj B

    2007-06-01

    Full Text Available Odontomas are benign tumors of odontogenic origin characterized by their slow growth. They are considered to be a common type of odontogenic tumor, but rarely occur in the primary dentition.The etiology of odontomas is unknown, although local trauma, infection and genetic factors have been suggested. Odontomas often cause disturbances in the eruption of teeth such as, impaction or delayed eruption, and retention of primary teeth and abnormalities in the position of teeth such as tipping or displacement of adjacent teeth. In this paper, a case of unerupted right mandibular primary cuspid in a 5 years old girl due to the presence of a compound odontoma is presented.

  5. Dilated odontoma: A report of two cases from a radiological perspective.

    Science.gov (United States)

    Jayachandran, S; Kayal, L; Sharma, Aatman; Priyanka, Khobre

    2016-01-01

    Dilated odontoma is the most extreme form of dens invaginatus. The lesion appears as a roughly spherical mass that does not resemble a tooth but in a way appears tooth - like on radiographs due to somewhat similar radiodensity. The lesion is mostly spherical in appearance and hence the term "dilated." Occasionally, we come across cases of simultaneous pathologies. Here, we report two cases of a dilated odontoma one of which is associated with dentigerous cyst and in other case dilated odontoma pushing the maxillary sinus superiorly. Histologically, the mass was composed of dentinal tubules. These morphological and histological features are compatible with those of a dilated odontoma.

  6. Odontoma intraóseo erupcionado: una infrecuente patología

    OpenAIRE

    Junquera Gutiérrez, Luis Manuel; Vicente Rodríguez, Juan Carlos de; Roig, Primitivo; Olay, S.; Rodríguez-Recio, Oliver

    2005-01-01

    Objetivos: Los odontomas que afectan a los tejidos blandos son muy infrecuentes, pudiendo presentarse bajo dos formas clinicas: odontoma periférico y odontoma erupcionado. Se documenta un caso de odontoma erupcionado con el objetivo de discutir entre ambas formas de presentación clínica de esta patología. Diseño del estudio: Estudio de caso. Resultados: Se presenta el caso de un varón con una masa dura localizada en la región posterior del reborde alveolar izquierdo de...

  7. Compound odontoma associated with an unerupted and dilacerated maxillary primary central incisor in a young patient.

    Science.gov (United States)

    Yeung, K H; Cheung, R C T; Tsang, M M H

    2003-05-01

    The occurrence of odontoma in the primary dentition is uncommon. There are very few reports of non-eruption of a dilacerated primary tooth in the literature. A rare case of compound odontoma in association with an unerupted dilacerated maxillary primary incisor in a young patient is reported. There was also a developing supernumerary tooth in the vicinity of the odontoma. The clinical features and management of these conditions are discussed. The relevant literature is reviewed. A possible causal relationship between odontoma and dilaceration is highlighted.

  8. Impactación por odontoma en asociación con alteración de la fórmula dentaria Impaction caused by odontoma associated with altered dental formula

    Directory of Open Access Journals (Sweden)

    Denia Morales Navarro

    2012-12-01

    . The physical examination found facial asymmetry with facial hard elastic augmentation in the right facial lower third. The Intraoral physical examination showed persistence of oral 65th and 85th , clinical absence of 15th , 47th and 48th with expansion of the vestibular and lingual cortices in the right posterior mandibular area (retromolar and molar regions and presence of rounded mucosal opening about 8 mm distal to the 46th , on top of the alveolar ridge. In the orthopantomographic study, a ± 3cm radiopaque image with irregular edges, associated with oligodontia of the 48th and impaction of the 47th , were observed. It was decided to surgically remove the lesion together with the 47th and to indicate histopathological study. It was confirmed that the patient had a complex odontoma with peripheral soft tissue areas that showed chronic inflammation. The patient is still followed-up from the clinical and imaging viewpoints after three months of surgery.

  9. Early removal of odontoma resulting in spontaneous eruption of the impacted teeth

    Directory of Open Access Journals (Sweden)

    Achmad Harijadi

    2010-06-01

    Full Text Available Background: Compound odontomas in the anterior maxilla during mixed dentition frequently cause obstruction to the eruption pathway of permanent upper anterior teeth. Removal of the odontomas may or may not lead to spontaneous eruption of the impacted teeth depending on the age when the surgery is performed, the size of the lesion, and the stage of tooth development of the involved teeth. Purpose: This paper attempts to emphasize the importance of early removal of compound odontoma to enable spontaneous eruption of the affected teeth. Case: A case of odontoma in the anterior maxilla causing failure of eruption and delayed root formation of upper right permanent lateral incisor and canine in a 10-year-old male patient is presented. Case management: The odontoma was surgically removed under general anesthesia and histology result confirmed the diagnosis of compound odontoma. A three-year post surgical follow up showed spontaneous eruption as well as continued root formation of the two affected teeth. Conclusion: Removal of odontoma may lead to spontaneous eruption of the affected teeth if their root development are not completed.Latar belakang: Compound odontoma pada daerah anterior maksila pada masa geligi pergantian sering menyebabkan hambatan erupsi pada gigi permanen penggantinya. Kemungkinan terjadinya erupsi spontan gigi permanen yang impaksi setelah pengambilan odontoma tergantung dari: umur penderita pada saat dilakukan operasi, ukuran lesi odontoma dan tahapan perkembangan gigi permanen yang terlibat. Tujuan: Laporan kasus ini ingin menekankan pentingnya pengambilan compound odontoma sedini mungkin untuk memberi kesempatan tumbuhnya gigi permanen yang terlibat dan erupsi secara spontan. Kasus: Ditampilkan sebuah kasus compound odontoma pada regio maksila anterior menyebabkan gagalnya erupsi dan terlambatnya pembentukan akar gigi insisif kedua dan kaninus permanent rahang atas kanan pada penderita anak laki-laki berumur 10 tahun

  10. Report of four cases of ameloblastic fibro-odontoma in mandible and discussion of the literature about the treatment.

    Science.gov (United States)

    Pontes, Helder Antonio Rebelo; Pontes, Flavia Sirotheau Correa; Lameira, Aladim Gomes; Salim, Rodrigo Alves; Carvalho, Pedro Luiz de; Guimarães, Douglas Magno; Pinto, Décio Dos Santos

    2012-02-01

    The ameloblastic fibro-odontoma is defined as a tumour with the general features of the ameloblastic fibroma but that also contains enamel and dentine. AFO normally presents as a painless swelling in the posterior portion of the maxilla or mandible. Radiographs show a well-defined radiolucent area containing various amounts of radiopaque material of irregular size and form. The most appropriate treatment for a large AFO has not been completely determined. This paper reports four large AFO cases and reviews the relevant literature regarding the clinical and surgical features of this lesion. Copyright © 2011 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

  11. Are large complex economic systems unstable ?

    CERN Document Server

    Sinha, Sitabhra

    2010-01-01

    Although classical economic theory is based on the concept of stable equilibrium, real economic systems appear to be always out of equilibrium. Indeed, they share many of the dynamical features of other complex systems, e.g., ecological food-webs. We focus on the relation between increasing complexity of the economic network and its stability with respect to small perturbations in the dynamical variables associated with the constituent nodes. Inherent delays and multiple time-scales suggest that economic systems will be more likely to exhibit instabilities as their complexity is increased even though the speed at which transactions are conducted has increased many-fold through technological developments. Analogous to the birth of nonlinear dynamics from Poincare's work on the question of whether the solar system is stable, we suggest that similar theoretical developments may arise from efforts by econophysicists to understand the mechanisms by which instabilities arise in the economy.

  12. Pharyngeal odontoma in an adult walleye (Sander vitreus).

    Science.gov (United States)

    Coffee, L L; Bogdanovic, L B; Cushing, T L; Bowser, P R

    2013-05-01

    An adult walleye (Sander vitreus) was submitted to Cornell University for evaluation of a hard pale-tan pharyngeal mass attached to the gill arches. Dozens of hard white conical structures radiated from the surface. Microscopically, conical structures were identified as denticles and rested on plates of dysplastic orthodentine, cementum, and acellular bone. A diagnosis of compound odontoma was made based upon the presence of proliferative epithelial and mesenchymal odontogenic tissues that recapitulated tooth structures normally present on gill rakers. Odontomas are classified as hamartomas and typically develop in immature diphyodont mammals. The pharyngeal location and lifelong regeneration of teeth in fish, however, both qualify the present diagnosis in the pharyngeal region of an adult teleost. Ontogenic and morphologic differences between mammalian and piscine dentition and differentials for tooth-bearing tumors in fish are presented within the context of a developmental anomaly.

  13. Compound odontoma causing airway obstruction of the newborn: a case report.

    Science.gov (United States)

    Tam, D; Francis, L; Perry, C; Thirwall, A

    2006-10-01

    A newborn presented with acute airway obstruction secondary to a compound odontoma of the hard palate/nasal floor. This is the first case recorded in the literature. We review the pathology of compound odontomas and discuss the management of this rare and interesting case.

  14. Occurrence of tumour (odontoma) in marine fish Sphyraena jello from the southeast coast of India.

    Science.gov (United States)

    Vijayakumar, R; Gopalakrishnan, A; Raja, K; Sinduja, K

    2014-02-04

    We examined the occurrence of odontoma in the marine fish Sphyraena jello sourced from 3 different landing centers (Cuddalore, Parangipettai and Nagapattinam) in Tamil Nadu (southeast India). A total of 19783 fishes were examined for odontoma presence, of which 2393 were affected with odontoma. The overall prevalence was 12.1% among the 3 stations. Fish landed at Parangipettai showed the highest peak prevalence of odontoma (16.8%) during the pre-monsoon, followed by Nagapatinam (9.1%) during summer 2011. The tumour lengths in premaxilla, supermaxilla and dentary bone were 1.1-3.6, 1.4-5.9 and 1.2-4.1 cm, respectively, and tumour widths were 0.3-1.9, 0.7-3.1 and 0.5-1.9 cm. Higher prevalence (0.206%) of tongue tumour along with odontoma was observed at Nagapattinam whereas it was lower (0.162%) at Cuddalore. Odontoma histopathology showed dense fibrous tissue with fine teeth roots. TEM analysis showed virus-like particles associated with odontoma. Radiography of the odontoma showed that the tumour masses were bony in nature and tissues were merged with upper and lower jaw.

  15. Ameloblastic fibro-odontoma: report of two cases.

    Science.gov (United States)

    Favia, G F; Di Alberti, L; Scarano, A; Piattelli, A

    1997-11-01

    Ameloblastic fibro-odontoma is a rare odontogenic tumour. It affects young people and is usually located in the posterior jaws. Two cases of this tumour are presented: both lesions had produced an asymptomatic swelling. The histology showed the presence of an odontogenic epithelium immersed in a fibrous mesenchyme; dental hard tissues were also present. No recurrences were found after 12 and 4 years from the surgical enucleation of the tumour.

  16. A Case Report of Compound Odontoma Associated with an Unerupted Maxillary Central Incisor

    Directory of Open Access Journals (Sweden)

    Eda Arat Maden

    2014-02-01

    Full Text Available Odontomas generally appear as small, solitary or multiple radio-opaque lesions found on routine radiographic examinations. Traditionally, odontomas are the most common type of odontogenic tumor and they are generally asymptomatic. Occasionally, odontomas may cause disturbances in the eruption of teeth, such as impaction, delay eruption or retention of primary teeth. In general, odontomas occur more often in the permanent dentition. This is a case report of a compound composite odontoma in an 8-year-old boy, which has resulted in failure of eruption of the permanent upper right central incisor while the contra-lateral tooth had erupted. [Arch Clin Exp Surg 2014; 3(1.000: 47-51

  17. Ameloblastic fibroma: a stage in the development of a hamartomatous odontoma or a true neoplasm? Critical analysis of 162 previously reported cases plus 10 new cases.

    Science.gov (United States)

    Buchner, Amos; Vered, Marilena

    2013-11-01

    To analyze neoplastic and hamartomatous variants of ameloblastic fibromas (AFs). Analysis of 172 cases (162 previously reported, 10 new). AF emerged as a lesion primarily of children and adolescents (mean age, 14.9 years), with about 80% diagnosed when odontogenesis is completed (age, 22 years are considered true neoplasms, while those in younger patients may be either true neoplasms or odontomas in early stages of development. Although the histopathology of hamartomatous and neoplastic variants of AF are indistinguishable, clinical and radiologic features can be of some help to distinguish between them. Asymptomatic small unilocular lesions with no or minimal bone expansion in young individuals are likely to be developing odontomas, and large, expansile lesions with extensive bone destruction are neoplasms. Copyright © 2013 Elsevier Inc. All rights reserved.

  18. Ameloblastic fibro-odontoma: expansile mixed radiolucent lesion in the posterior maxilla: a case report.

    Science.gov (United States)

    Zouhary, Kenneth J; Said-Al-Naief, Nasser; Waite, Peter D

    2008-10-01

    Ameloblastic fibro-odontoma (AFO) is a benign tumor that displays properties of both ameloblastic fibroma and compound odontoma. Often, AFO presents clinically as a hamartoma or immature odontoma; however, the tumor can also present with progressive growth causing bone destruction and significant deformity, acting more like a true neoplasm. We report a case of a locally aggressive AFO in the posterior maxilla of a 7-year-old girl and discuss the clinical, radiographic, histopathologic, and conservative therapeutic approach to this locally aggressive tumor.

  19. Eruption of Odontomas into the Oral Cavity: A Report of 2 Cases

    Directory of Open Access Journals (Sweden)

    Sreenivasan Bhargavan Sarojini

    2014-01-01

    Full Text Available Odontomas are the commonest odontogenic tumors of the oral cavity and are by nature asymptomatic. They consist mainly of dental tissue that may or may not be arranged in an orderly fashion. Their presence is often detected accidentally or due to the presence of a dental disturbance such as an unerupted tooth. The very rarity of odontomas erupting into the oral cavity validates the need for more current literature on the phenomenon. Our report of two cases aims to present and discuss the rare event of an erupting odontoma with the dental community.

  20. Isolation and identification of marine fish tumour (odontoma) associated bacteria

    Institute of Scientific and Technical Information of China (English)

    Ramalingam Vijayakumar; Kuzhanthaivel Raja; Vijayapoopathi Singaravel; Ayyaru Gopalakrishnan

    2015-01-01

    Objective: To identify fish tumour associated bacteria. Methods: The marine fish Sphyraena jello with odontoma was collected from in Tamil Nadu (Southeast India), and tumour associated bacteria were isolated. Then the isolated bacteria were identified based on molecular characters. Results: A total of 4 different bacterial species were isolated from tumour tissue. The bacterial species were Bacillus sp., Pontibacter sp., Burkholderia sp. and Macrococcus sp., and the sequences were submitted in DNA Data Bank of Japan with accession numbers of AB859240, AB859241, AB859242 and AB859243 respectively. Conclusions: Four different bacterial species were isolated from Sphyraena jello, but the role of bacteria within tumour needs to be further investigated.

  1. COMPLEXITY OF LARGE TIME BEHAVIOUR OFEVOLUTION EQUATIONS WITH BOUNDED DATA

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    The authors study the asymptotic behaviour of solutions of the heat equation and a number of evolution equations using scaling techniques. It is proved that in the framework of bounded data stabilization need not occur and the general asymptotic behaviour is complex. This behaviour reflects for large times,even on compact sets,the complexity of the initial data at infinity.

  2. Tight Sample Complexity of Large-Margin Learning

    CERN Document Server

    Sabato, Sivan; Tishby, Naftali

    2010-01-01

    We obtain a tight distribution-specific characterization of the sample complexity of large-margin classification with L_2 regularization: We introduce the \\gamma-adapted-dimension, which is a simple function of the spectrum of a distribution's covariance matrix, and show distribution-specific upper and lower bounds on the sample complexity, both governed by the \\gamma-adapted-dimension of the source distribution. We conclude that this new quantity tightly characterizes the true sample complexity of large-margin classification. The bounds hold for a rich family of sub-Gaussian distributions.

  3. [Ameloblastic fibro-odontoma. Clinical aspects and review of the literature].

    Science.gov (United States)

    Villareal, P M; Junquera, L M; Albertos, J M; Molina, R; Gonzalez, S; Villarreal, P M

    1998-02-01

    Ameloblastic fibro-odontoma is a rare odontogenic tumor. It is formed by proliferation of epithelial odontogenic elements combined with ectomesechimal tissue. The presence of dentine, enamel and osteoid like tissue can be identified. Cases of sarcomatous degeneration have been described. In this work, we present two new cases of ameloblastic fibro-odontoma, analyzing the most important aspects of their differential diagnosis, with a review of literature.

  4. A Peduncular Cystic Compound Odontoma on the Posterior Wall of the Maxillary Sinus

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Byung Chul [Dept. of Oral and Maxillofacial Radiology, College of Dentistry, Chonam National University, Kwangju (Korea, Republic of)

    1998-08-15

    A cystic compound odontoma in the maxillary sinus occurred in a 13-years-old boy, who had missing right upper third molar without having the history of extraction of the wisdom tooth. He complained nasal stuffiness, headache, and pain on the affected face, resembling any sign and symptoms of the maxillary sinus problems. The cysteic compound, sized 2 x 1.5 cm in diameter was pedunculated and attached on the posterior wall of the right maxillary sinus and above the antral floor. The location of the compound odontoma in the maxillary sinus was confirmed after panoramic, waters, spiral tomographic, CT examinations and surgical exploration. Irs location was on the medical, posterior, superior to the normal position of the maxillary third molar or the maxillary dental arch. The cystic odontoma in the maxillary sinus made the patient have the sings and symptoms of maxillary sinusitis. The cystic compound odontoma might be originated from the dental lamina of the missing upper right third molar. The 'V principle' of the upper jaw growth and the pneumatization process of the maxillary sinus could explain why the compound odontoma had peduncular shape and the location of odontoma was on the medial, superior to the normal position of the maxillary dental arch.

  5. Habitat Complexity Metrics to Guide Restoration of Large Rivers

    Science.gov (United States)

    Jacobson, R. B.; McElroy, B. J.; Elliott, C.; DeLonay, A.

    2011-12-01

    Restoration strategies on large, channelized rivers typically strive to recover lost habitat complexity, based on the assumption complexity and biophysical capacity are directly related. Although definition of links between complexity and biotic responses can be tenuous, complexity metrics have appeal because of their potential utility in quantifying habitat quality, defining reference conditions and design criteria, and measuring restoration progress. Hydroacoustic instruments provide many ways to measure complexity on large rivers, yet substantive questions remain about variables and scale of complexity that are meaningful to biota, and how complexity can be measured and monitored cost effectively. We explore these issues on the Missouri River, using the example of channel re-engineering projects that are intended to aid in recovery of the pallid sturgeon, an endangered benthic fish. We are refining understanding of what habitat complexity means for adult fish by combining hydroacoustic habitat assessments with acoustic telemetry to map locations during reproductive migrations and spawning. These data indicate that migrating sturgeon select points with relatively low velocity but adjacent to areas of high velocity (that is, with high velocity gradients); the integration of points defines pathways which minimize energy expenditures during upstream migrations of 10's to 100's of km. Complexity metrics that efficiently quantify migration potential at the reach scale are therefore directly relevant to channel restoration strategies. We are also exploring complexity as it relates to larval sturgeon dispersal. Larvae may drift for as many as 17 days (100's of km at mean velocities) before using up their yolk sac, after which they "settle" into habitats where they initiate feeding. An assumption underlying channel re-engineering is that additional channel complexity, specifically increased shallow, slow water, is necessary for early feeding and refugia. Development of

  6. Research and assessment of competitiveness of large engineering complexes

    Directory of Open Access Journals (Sweden)

    Krivorotov V.V.

    2017-01-01

    Full Text Available The urgency of the problem of ensuring the competitiveness of manufacturing and high-tech sectors is shown. Substantiated the decisive role of the large industrial complexes in the formation of the results of the national economy; the author’s interpretation of the concept of “industrial complex” with regard to current economic systems. Current approaches to assessing the competitiveness of enterprises and industrial complexes are analyzed; showing their main advantages and disadvantages. Provides scientific-methodological approach to the study and management of competitiveness of a large industrial complex; the description of its main units is provided. As a Central element of the scientific methodology approach proposed the methodology for assessing the competitiveness of a large industrial complex based on the Pattern-method; a modular system of indicators of competitiveness is developed and its adaptation to a large engineering complexes is made. Using the developed methodology the competitiveness of one of the largest engineering complexes of the group of companies Uralelectrotyazhmash, which is the leading enterprises in electrotechnical industry of Russia is assessed. The evaluation identified the main problems and bottlenecks in the development of these enterprises, and their comparison with leading competitors is provided. According to the results of the study the main conclusions and recommendations are formed.

  7. Complexity Measurement of Large-Scale Software System Based on Complex Network

    Directory of Open Access Journals (Sweden)

    Dali Li

    2014-05-01

    Full Text Available With the increase of software system complexity, the traditional measurements can not meet the requirements, for the reason that the developers need control the software quality effectively and guarantee the normal operation of software system. Hence how to measure the complexity of large-scale software system has been a challenge problem. In order to solve this problem, the developers have to obtain a good method to measure the complexity of software system first. Only through this work, the software quality and the software structure could be controlled and optimized. Note that the complex network theory has offered a new theoretical understanding and a new perspective to solve this kind of complexity problem, this work discusses the complexity phenomenon in large-scale software system. Based on this, some complexity measurements of large-scale software system are put forward from static structure and dynamic structure perspectives. Furthermore, we find some potential complexity characteristics in large-scale software networks through the numerical simulations. The proposed measurement methods have a guiding significance on the development for today's large-scale software system. In addition, this paper presents a new technique for the structural complexity measurements of large-scale software system

  8. Large-scale computing techniques for complex system simulations

    CERN Document Server

    Dubitzky, Werner; Schott, Bernard

    2012-01-01

    Complex systems modeling and simulation approaches are being adopted in a growing number of sectors, including finance, economics, biology, astronomy, and many more. Technologies ranging from distributed computing to specialized hardware are explored and developed to address the computational requirements arising in complex systems simulations. The aim of this book is to present a representative overview of contemporary large-scale computing technologies in the context of complex systems simulations applications. The intention is to identify new research directions in this field and

  9. Isolation and identification of marine fish tumour (odontoma associated bacteria

    Directory of Open Access Journals (Sweden)

    Ramalingam Vijayakumar

    2015-09-01

    Full Text Available Objective: To identify fish tumour associated bacteria. Methods: The marine fish Sphyraena jello with odontoma was collected from in Tamil Nadu (Southeast India, and tumour associated bacteria were isolated. Then the isolated bacteria were identified based on molecular characters. Results: A total of 4 different bacterial species were isolated from tumour tissue. The bacterial species were Bacillus sp., Pontibacter sp., Burkholderia sp. and Macrococcus sp., and the sequences were submitted in DNA Data Bank of Japan with accession numbers of AB859240, AB859241, AB859242 and AB859243 respectively. Conclusions: Four different bacterial species were isolated from Sphyraena jello, but the role of bacteria within tumour needs to be further investigated.

  10. First permanent molar root development arrest associated with compound odontoma.

    Science.gov (United States)

    Gunda, Sachin A; Patil, Anil; Varekar, Aniruddha

    2013-07-04

    Trauma or infection to the primary tooth may have deleterious effects on the underlying developing tooth buds. Anatomically the root apices of primary teeth are in close proximity to the developing permanent tooth buds; hence spread of infection originating from pulp necrosis of primary tooth may not only affect the underlying tooth bud but may also affect the adjacent tooth buds. The extent of malformation depends on the developmental stage of tooth or the age of patient. Presented here is a rare case of complete arrest of maxillary first permanent molar root growth due to spread of periapical infection originating from second primary molar leading to failure of its eruption and finally extraction. Histopathlogical analysis revealed compound odontoma associated with maxillary first permanent molar.

  11. Structuring and assessing large and complex decision problems using MCDA

    DEFF Research Database (Denmark)

    Barfod, Michael Bruhn

    This paper presents an approach for the structuring and assessing of large and complex decision problems using multi-criteria decision analysis (MCDA). The MCDA problem is structured in a decision tree and assessed using the REMBRANDT technique featuring a procedure for limiting the number of pair...

  12. Fibro-odontoma ameloblástico de la mandíbula Ameloblastic fibro-odontoma of the jaw

    OpenAIRE

    María Loreto Castellón; Rodrigo Fariña; Benjamín Martínez; Loreto Canto; Renato Gunckel

    2013-01-01

    El fibro-odontoma ameloblástico (FOA) es un tumor odontogénico poco frecuente que afecta a personas jóvenes, sin predilección por género y usualmente se localiza en la zona posterior de la mandíbula. Clínicamente el paciente puede presentar retraso en la erupción dentaria acompañado de aumento de volumen indoloro. Radiográficamente es una lesión radiolúcida uni o multilocular de tamaño variable con áreas radiopacas. El tratamiento varía de acuerdo a su tamaño y se debe tener especial cuidado ...

  13. Small shape deviations causes complex dynamics in large electric generators

    Science.gov (United States)

    Lundström, Niklas L. P.; Grafström, Anton; Aidanpää, Jan-Olov

    2014-05-01

    We prove that combinations of small eccentricity, ovality and/or triangularity in the rotor and stator can produce complex whirling motions of an unbalanced rotor in large synchronous generators. It is concluded which structures of shape deviations that are more harmful, in the sense of producing complex whirling motions, than others. For each such structure, we derive simplified equations of motions from which we conclude analytically the relation between shape deviations and mass unbalance that yield non-smooth whirling motions. Finally we discuss validity of our results in the sense of modeling of the unbalanced magnetic pull force.

  14. Activated WNT signaling in postnatal SOX2-positive dental stem cells can drive odontoma formation.

    Science.gov (United States)

    Xavier, Guilherme M; Patist, Amanda L; Healy, Chris; Pagrut, Ankita; Carreno, Gabriela; Sharpe, Paul T; Martinez-Barbera, Juan Pedro; Thavaraj, Selvam; Cobourne, Martyn T; Andoniadou, Cynthia L

    2015-09-28

    In common with most mammals, humans form only two dentitions during their lifetime. Occasionally, supernumerary teeth develop in addition to the normal complement. Odontoma represent a small group of malformations containing calcified dental tissues of both epithelial and mesenchymal origin, with varying levels of organization, including tooth-like structures. The specific cell type responsible for the induction of odontoma, which retains the capacity to re-initiate de novo tooth development in postnatal tissues, is not known. Here we demonstrate that aberrant activation of WNT signaling by expression of a non-degradable form of β-catenin specifically in SOX2-positive postnatal dental epithelial stem cells is sufficient to generate odontoma containing multiple tooth-like structures complete with all dental tissue layers. Genetic lineage-tracing confirms that odontoma form in a similar manner to normal teeth, derived from both the mutation-sustaining epithelial stem cells and adjacent mesenchymal tissues. Activation of the WNT pathway in embryonic SOX2-positive progenitors results in ectopic expression of secreted signals that promote odontogenesis throughout the oral cavity. Significantly, the inductive potential of epithelial dental stem cells is retained in postnatal tissues, and up-regulation of WNT signaling specifically in these cells is sufficient to promote generation and growth of ectopic malformations faithfully resembling human odontoma.

  15. Activated WNT signaling in postnatal SOX2-positive dental stem cells can drive odontoma formation

    Science.gov (United States)

    Xavier, Guilherme M.; Patist, Amanda L.; Healy, Chris; Pagrut, Ankita; Carreno, Gabriela; Sharpe, Paul T.; Pedro Martinez-Barbera, Juan; Thavaraj, Selvam; Cobourne, Martyn T.; Andoniadou, Cynthia L.

    2015-01-01

    In common with most mammals, humans form only two dentitions during their lifetime. Occasionally, supernumerary teeth develop in addition to the normal complement. Odontoma represent a small group of malformations containing calcified dental tissues of both epithelial and mesenchymal origin, with varying levels of organization, including tooth-like structures. The specific cell type responsible for the induction of odontoma, which retains the capacity to re-initiate de novo tooth development in postnatal tissues, is not known. Here we demonstrate that aberrant activation of WNT signaling by expression of a non-degradable form of β-catenin specifically in SOX2-positive postnatal dental epithelial stem cells is sufficient to generate odontoma containing multiple tooth-like structures complete with all dental tissue layers. Genetic lineage-tracing confirms that odontoma form in a similar manner to normal teeth, derived from both the mutation-sustaining epithelial stem cells and adjacent mesenchymal tissues. Activation of the WNT pathway in embryonic SOX2-positive progenitors results in ectopic expression of secreted signals that promote odontogenesis throughout the oral cavity. Significantly, the inductive potential of epithelial dental stem cells is retained in postnatal tissues, and up-regulation of WNT signaling specifically in these cells is sufficient to promote generation and growth of ectopic malformations faithfully resembling human odontoma. PMID:26411543

  16. Complex protein nanopatterns over large areas via colloidal lithography

    DEFF Research Database (Denmark)

    Kristensen, Stine H; Pedersen, Gitte Albinus; Ogaki, Ryosuke;

    2013-01-01

    are used to generate complex protein nanopatterns over large areas. Simple circular patches or more complex ring structures are produced in addition to hierarchical patterns of smaller patches. The gold regions are modified through alkanethiol chemistry, which enables the preparation of extracellular......The patterning of biomolecules at the nanoscale provides a powerful method to investigate cellular adhesion processes. A novel method for patterning is presented that is based on colloidal monolayer templating combined with multiple and angled deposition steps. Patterns of gold and SiO2 layers...... for using sets of systematically varied samples with simpler or more complex patterns for studies of cellular adhesive behavior and reveal that the local distribution of proteins within a simple patch critically influences cell adhesion....

  17. Fibro-odontoma ameloblástico: a propósito de un caso Report of a case of Fibrous Ameloblastic Odontoma

    Directory of Open Access Journals (Sweden)

    P. Reyes Olave

    2009-10-01

    diagnosed as FAO and then surgically removed. Results. Although the patient fell into the typical age range and they FAO was located in the typical area, the definitive diagnostic could only be decided until after the results of the histological study of the removed tooth were reviewed. Discussion. FAO diagnosis normally creates confusion from both a histological and a clinical radiographic point of view. It is difficult differentiate between FAO and Complex Immature Odontoma (OIC. Like in this case, the differences are detected later when the histological study is complete. Conclusion. FAO is independent from OIC and its diagnostic greatly depends on the histological discoveries and the clinical radiographic correlation carried out when the pathology is first dealt with.

  18. Finding consistent gene transmission patterns on large and complex pedigrees.

    Science.gov (United States)

    Pirinen, Matti; Gasbarra, Dario

    2006-01-01

    A heuristic algorithm for finding gene transmission patterns on large and complex pedigrees with partially observed genotype data is proposed. The method can be used to generate an initial point for a Markov chain Monte Carlo simulation or to check that the given pedigree and the genotype data are consistent. In small pedigrees, the algorithm is exact by exhaustively enumerating all possibilities, but, in large pedigrees, with a considerable amount of unknown data, only a subset of promising configurations can actually be checked. For that purpose, the configurations are ordered by combining the approximative conditional probability distribution of the unknown genotypes with the information on the relationships between individuals. We also introduce a way to divide the task into subparts, which has been shown to be useful in large pedigrees. The algorithm has been implemented in a program called APE (Allelic Path Explorer) and tested in three different settings with good results.

  19. Management of a massive compound odontoma in a 9-year child

    Directory of Open Access Journals (Sweden)

    Yogesh J Kale

    2016-01-01

    Full Text Available The purpose of this paper is to describe the case of surgical management of massive compound odontoma with 36 denticles in a 9-year-boy who presented with a complaint of pain and swelling in mandibular left posterior region and retained 74. The denticles were removed after the removal of retained 74 completely and wound healing was observed. Odontomas are considered as hamartomatous dental malformation rather than true neoplasm of odontogenic origin. They are the most commonly occurring abnormally formed dental tissues that interfere with eruption of associated teeth. The eruption disturbances seen due to odontomas are delayed eruption or deflection of associated teeth. These malformations are usually asymptomatic and discovered during routine radiographic investigations. Correct diagnosis followed by proper treatment plan results in a favorable prognosis.

  20. Ameloblastic fibro-odontoma in children. Clinical aspects and review of the literature

    Directory of Open Access Journals (Sweden)

    Marcello Augello

    2017-06-01

    Full Text Available The ameloblastic fibro-odontoma (AFO is a rare mixed odontogenic tumor. Clinically AFO presents as a hamartoma or immature odontoma. The AFO is a well-encapsulated, painless, slow-growing and expanding tumor in young patients. Histologically, it has been classified as an ameloblastic fibroma or odontoma. Despite numerous efforts, there is still considerable confusion concerning the nature, the histology and the surgical therapy of this lesion. However, it can present with progressive growth causing bone destruction and significant deformity. The transformation of AFO in sarcoma is also known and extremely rare. Therefore a long term follow up is recommended. Enucleation still remains the gold standard. We are discussing our experience with AFO focused on children in clinical and surgical features and reviewing the relevant literature.

  1. Management of a massive compound odontoma in a 9-year child

    Science.gov (United States)

    Kale, Yogesh J.; Dahake, Prasanna T.; Patil, Prasannakumari S.; Dadpe, Mahesh V.

    2016-01-01

    The purpose of this paper is to describe the case of surgical management of massive compound odontoma with 36 denticles in a 9-year-boy who presented with a complaint of pain and swelling in mandibular left posterior region and retained 74. The denticles were removed after the removal of retained 74 completely and wound healing was observed. Odontomas are considered as hamartomatous dental malformation rather than true neoplasm of odontogenic origin. They are the most commonly occurring abnormally formed dental tissues that interfere with eruption of associated teeth. The eruption disturbances seen due to odontomas are delayed eruption or deflection of associated teeth. These malformations are usually asymptomatic and discovered during routine radiographic investigations. Correct diagnosis followed by proper treatment plan results in a favorable prognosis. PMID:27630512

  2. Erupted and nonerupted compound odontoma in prosthodontic patients: Report of two cases

    Directory of Open Access Journals (Sweden)

    Santosh R Patil

    2016-01-01

    Full Text Available The odontomas constitute most common benign odontogenic tumors of the jaws. Majority of odontomas are nonsymptomatic and are detected on routine radiographic examination. They represent up to 22% of all odontogenic tumors of the jaws. This lesion is composed of more than one type of odontogenic tissues and for this reason, it is also known a composite odontoma. In a 32-year-old male, well-defined small teeth like structure were noticed distal to maxillary second molars bilaterally which were confirmed radiologically and histopathologically as eruption odontome. In the second case, multiple miniature tooth-like structures of varying densities were observed pericoronally to the impacted canine on the X-ray, which was confirmed as compound histologically.

  3. Management of a massive compound odontoma in a 9-year child.

    Science.gov (United States)

    Kale, Yogesh J; Dahake, Prasanna T; Patil, Prasannakumari S; Dadpe, Mahesh V

    2016-01-01

    The purpose of this paper is to describe the case of surgical management of massive compound odontoma with 36 denticles in a 9-year-boy who presented with a complaint of pain and swelling in mandibular left posterior region and retained 74. The denticles were removed after the removal of retained 74 completely and wound healing was observed. Odontomas are considered as hamartomatous dental malformation rather than true neoplasm of odontogenic origin. They are the most commonly occurring abnormally formed dental tissues that interfere with eruption of associated teeth. The eruption disturbances seen due to odontomas are delayed eruption or deflection of associated teeth. These malformations are usually asymptomatic and discovered during routine radiographic investigations. Correct diagnosis followed by proper treatment plan results in a favorable prognosis.

  4. Large-Scale Optimization for Bayesian Inference in Complex Systems

    Energy Technology Data Exchange (ETDEWEB)

    Willcox, Karen [MIT; Marzouk, Youssef [MIT

    2013-11-12

    The SAGUARO (Scalable Algorithms for Groundwater Uncertainty Analysis and Robust Optimization) Project focused on the development of scalable numerical algorithms for large-scale Bayesian inversion in complex systems that capitalize on advances in large-scale simulation-based optimization and inversion methods. The project was a collaborative effort among MIT, the University of Texas at Austin, Georgia Institute of Technology, and Sandia National Laboratories. The research was directed in three complementary areas: efficient approximations of the Hessian operator, reductions in complexity of forward simulations via stochastic spectral approximations and model reduction, and employing large-scale optimization concepts to accelerate sampling. The MIT--Sandia component of the SAGUARO Project addressed the intractability of conventional sampling methods for large-scale statistical inverse problems by devising reduced-order models that are faithful to the full-order model over a wide range of parameter values; sampling then employs the reduced model rather than the full model, resulting in very large computational savings. Results indicate little effect on the computed posterior distribution. On the other hand, in the Texas--Georgia Tech component of the project, we retain the full-order model, but exploit inverse problem structure (adjoint-based gradients and partial Hessian information of the parameter-to-observation map) to implicitly extract lower dimensional information on the posterior distribution; this greatly speeds up sampling methods, so that fewer sampling points are needed. We can think of these two approaches as ``reduce then sample'' and ``sample then reduce.'' In fact, these two approaches are complementary, and can be used in conjunction with each other. Moreover, they both exploit deterministic inverse problem structure, in the form of adjoint-based gradient and Hessian information of the underlying parameter-to-observation map, to

  5. Contribution of large region joint associations to complex traits genetics.

    Science.gov (United States)

    Paré, Guillaume; Asma, Senay; Deng, Wei Q

    2015-04-01

    A polygenic model of inheritance, whereby hundreds or thousands of weakly associated variants contribute to a trait's heritability, has been proposed to underlie the genetic architecture of complex traits. However, relatively few genetic variants have been positively identified so far and they collectively explain only a small fraction of the predicted heritability. We hypothesized that joint association of multiple weakly associated variants over large chromosomal regions contributes to complex traits variance. Confirmation of such regional associations can help identify new loci and lead to a better understanding of known ones. To test this hypothesis, we first characterized the ability of commonly used genetic association models to identify large region joint associations. Through theoretical derivation and simulation, we showed that multivariate linear models where multiple SNPs are included as independent predictors have the most favorable association profile. Based on these results, we tested for large region association with height in 3,740 European participants from the Health and Retirement Study (HRS) study. Adjusting for SNPs with known association with height, we demonstrated clustering of weak associations (p = 2x10-4) in regions extending up to 433.0 Kb from known height loci. The contribution of regional associations to phenotypic variance was estimated at 0.172 (95% CI 0.063-0.279; p < 0.001), which compared favorably to 0.129 explained by known height variants. Conversely, we showed that suggestively associated regions are enriched for known height loci. To extend our findings to other traits, we also tested BMI, HDLc and CRP for large region associations, with consistent results for CRP. Our results demonstrate the presence of large region joint associations and suggest these can be used to pinpoint weakly associated SNPs.

  6. Compound odontoma associated with an unerupted rotated and dilacerated maxillary central incisor

    Directory of Open Access Journals (Sweden)

    Vinaya Kumar Kulkarni

    2011-01-01

    Full Text Available Odontomas are benign tumors containing various component tissues of teeth. They usually remain asymptomatic and are diagnosed on routine radiographs. Clinically, they are often associated with delayed eruption or impaction of permanent teeth and retained primary teeth. A case of compound odontoma in association with an unerupted, rotated and dilacerated maxillary permanent right central incisor in a 12-year-old boy is reported. Such combination is rare, making it an interesting case for reporting. We have also discussed the clinical features, diagnosis and treatment of such a condition.

  7. Large Scale Emerging Properties from Non Hamiltonian Complex Systems

    Directory of Open Access Journals (Sweden)

    Marco Bianucci

    2017-06-01

    Full Text Available The concept of “large scale” depends obviously on the phenomenon we are interested in. For example, in the field of foundation of Thermodynamics from microscopic dynamics, the spatial and time large scales are order of fraction of millimetres and microseconds, respectively, or lesser, and are defined in relation to the spatial and time scales of the microscopic systems. In large scale oceanography or global climate dynamics problems the time scales of interest are order of thousands of kilometres, for space, and many years for time, and are compared to the local and daily/monthly times scales of atmosphere and ocean dynamics. In all the cases a Zwanzig projection approach is, at least in principle, an effective tool to obtain class of universal smooth “large scale” dynamics for few degrees of freedom of interest, starting from the complex dynamics of the whole (usually many degrees of freedom system. The projection approach leads to a very complex calculus with differential operators, that is drastically simplified when the basic dynamics of the system of interest is Hamiltonian, as it happens in Foundation of Thermodynamics problems. However, in geophysical Fluid Dynamics, Biology, and in most of the physical problems the building block fundamental equations of motions have a non Hamiltonian structure. Thus, to continue to apply the useful projection approach also in these cases, we exploit the generalization of the Hamiltonian formalism given by the Lie algebra of dissipative differential operators. In this way, we are able to analytically deal with the series of the differential operators stemming from the projection approach applied to these general cases. Then we shall apply this formalism to obtain some relevant results concerning the statistical properties of the El Niño Southern Oscillation (ENSO.

  8. Large scale molecular dynamics study of polymer-surfactant complex

    Science.gov (United States)

    Goswami, Monojoy; Sumpter, Bobby

    2012-02-01

    In this work, we study the self-assembly of cationic polyelectrolytes mediated by anionic surfactants in dilute or semi-dilute and gel states. The understanding of the dilute system is a requirement for the understanding of gel states. The importance of polyelectrolyte with oppositely charged colloidal particles can be found in biological systems, such as immobilization of enzymes in polyelectrolyte complexes or nonspecific association of DNA with protein. With the same understanding, interaction of surfactants with polyelectrolytes shows intriguing phenomena that are important for both in academic research as well as industrial applications. Many useful properties of PE surfactant complexes come from the highly ordered structures of surfactant self-assembly inside the PE aggregate. We do large scale molecular dynamics simulation using LAMMPS to understand the structure and dynamics of PE-surfactant systems. Our investigation shows highly ordered ring-string structures that have been observed experimentally in biological systems. We will investigate many different properties of PE-surfactant complexation which will be helpful for pharmaceutical, engineering and biological applications.

  9. The Internet As a Large-Scale Complex System

    Science.gov (United States)

    Park, Kihong; Willinger, Walter

    2005-06-01

    The Internet may be viewed as a "complex system" with diverse features and many components that can give rise to unexpected emergent phenomena, revealing much about its own engineering. This book brings together chapter contributions from a workshop held at the Santa Fe Institute in March 2001. This volume captures a snapshot of some features of the Internet that may be fruitfully approached using a complex systems perspective, meaning using interdisciplinary tools and methods to tackle the subject area. The Internet penetrates the socioeconomic fabric of everyday life; a broader and deeper grasp of the Internet may be needed to meet the challenges facing the future. The resulting empirical data have already proven to be invaluable for gaining novel insights into the network's spatio-temporal dynamics, and can be expected to become even more important when tryin to explain the Internet's complex and emergent behavior in terms of elementary networking-based mechanisms. The discoveries of fractal or self-similar network traffic traces, power-law behavior in network topology and World Wide Web connectivity are instances of unsuspected, emergent system traits. Another important factor at the heart of fair, efficient, and stable sharing of network resources is user behavior. Network systems, when habited by selfish or greedy users, take on the traits of a noncooperative multi-party game, and their stability and efficiency are integral to understanding the overall system and its dynamics. Lastly, fault-tolerance and robustness of large-scale network systems can exhibit spatial and temporal correlations whose effective analysis and management may benefit from rescaling techniques applied in certain physical and biological systems. The present book will bring together several of the leading workers involved in the analysis of complex systems with the future development of the Internet.

  10. Peripheral Developing Odontoma or Peripheral Ameloblastic Fibroodontoma: A Rare Challenging Case

    Directory of Open Access Journals (Sweden)

    Saede Atarbashi Moghadam

    2016-01-01

    Full Text Available Peripheral odontogenic lesions are considered to be rare within the classification of odontogenic tumors. They share the same microscopic characteristics of their central counterparts. Here, we report an ulcerated mass of the maxillary gingiva that on histopathological examination was diagnosed as peripheral developing odontoma or peripheral ameloblastic fibroodontoma. The diagnosis of this tumor is challenging and may lead to unnecessary treatment.

  11. Peripheral Developing Odontoma or Peripheral Ameloblastic Fibroodontoma: A Rare Challenging Case

    Science.gov (United States)

    Atarbashi Moghadam, Saede

    2016-01-01

    Peripheral odontogenic lesions are considered to be rare within the classification of odontogenic tumors. They share the same microscopic characteristics of their central counterparts. Here, we report an ulcerated mass of the maxillary gingiva that on histopathological examination was diagnosed as peripheral developing odontoma or peripheral ameloblastic fibroodontoma. The diagnosis of this tumor is challenging and may lead to unnecessary treatment. PMID:26981293

  12. Peripheral Developing Odontoma or Peripheral Ameloblastic Fibroodontoma: A Rare Challenging Case.

    Science.gov (United States)

    Atarbashi Moghadam, Saede; Mokhtari, Sepideh

    2016-01-01

    Peripheral odontogenic lesions are considered to be rare within the classification of odontogenic tumors. They share the same microscopic characteristics of their central counterparts. Here, we report an ulcerated mass of the maxillary gingiva that on histopathological examination was diagnosed as peripheral developing odontoma or peripheral ameloblastic fibroodontoma. The diagnosis of this tumor is challenging and may lead to unnecessary treatment.

  13. Peripheral Tumor with Osteodentin and Cementum-like Material in an Infant: Odontogenic Hamartoma or Odontoma?

    Science.gov (United States)

    Sfakianou, Aikaterini; Emmanouil, Dimitris E; Tosios, Konstantinos I; Sklavounou, Alexandra

    2016-01-01

    The purpose of this report is to describe a peripheral tumor on the mandibular alveolar ridge of a seven-month-old Caucasian boy, consisting of ectomesencymal odontogenic tissues, in particular osteodentin and cementum-like material, in a cellular or loose vascular connective tissue stroma. This case may be considered either a peripheral odontogenic hamartoma or a peripheral odontoma.

  14. Efficient and Accurate Robustness Estimation for Large Complex Networks

    CERN Document Server

    Wandelt, Sebastian

    2016-01-01

    Robustness estimation is critical for the design and maintenance of resilient networks, one of the global challenges of the 21st century. Existing studies exploit network metrics to generate attack strategies, which simulate intentional attacks in a network, and compute a metric-induced robustness estimation. While some metrics are easy to compute, e.g. degree centrality, other, more accurate, metrics require considerable computation efforts, e.g. betweennes centrality. We propose a new algorithm for estimating the robustness of a network in sub-quadratic time, i.e., significantly faster than betweenness centrality. Experiments on real-world networks and random networks show that our algorithm estimates the robustness of networks close to or even better than betweenness centrality, while being orders of magnitudes faster. Our work contributes towards scalable, yet accurate methods for robustness estimation of large complex networks.

  15. Reorganizing Complex Network to Improve Large-Scale Multiagent Teamwork

    Directory of Open Access Journals (Sweden)

    Yang Xu

    2014-01-01

    Full Text Available Large-scale multiagent teamwork has been popular in various domains. Similar to human society infrastructure, agents only coordinate with some of the others, with a peer-to-peer complex network structure. Their organization has been proven as a key factor to influence their performance. To expedite team performance, we have analyzed that there are three key factors. First, complex network effects may be able to promote team performance. Second, coordination interactions coming from their sources are always trying to be routed to capable agents. Although they could be transferred across the network via different paths, their sources and sinks depend on the intrinsic nature of the team which is irrelevant to the network connections. In addition, the agents involved in the same plan often form a subteam and communicate with each other more frequently. Therefore, if the interactions between agents can be statistically recorded, we are able to set up an integrated network adjustment algorithm by combining the three key factors. Based on our abstracted teamwork simulations and the coordination statistics, we implemented the adaptive reorganization algorithm. The experimental results briefly support our design that the reorganized network is more capable of coordinating heterogeneous agents.

  16. Reduced Complexity Divide and Conquer Algorithm for Large Scale TSPs

    Directory of Open Access Journals (Sweden)

    Hoda A. Darwish

    2014-01-01

    Full Text Available The Traveling Salesman Problem (TSP is the problem of finding the shortest path passing through all given cities while only passing by each city once and finishing at the same starting city. This problem has NP-hard complexity making it extremely impractical to get the most optimal path even for problems as small as 20 cities since the number of permutations becomes too high. Many heuristic methods have been devised to reach “good” solutions in reasonable time. In this paper, we present the idea of utilizing a spatial “geographical” Divide and Conquer technique in conjunction with heuristic TSP algorithms specifically the Nearest Neighbor 2-opt algorithm. We have found that the proposed algorithm has lower complexity than algorithms published in the literature. This comes at a lower accuracy expense of around 9%. It is our belief that the presented approach will be welcomed to the community especially for large problems where a reasonable solution could be reached in a fraction of the time.

  17. Congenital peripheral developing odontoma accompanied by congenital teratomatous fibroma in a 9-month-old boy: a case report.

    Science.gov (United States)

    Mikami, Toshinari; Yagi, Masaatsu; Mizuki, Harumi; Takeda, Yasunori

    2013-03-01

    Peripheral odontoma is rare, and only two cases of congenital peripheral odontoma have been reported. Congenital oral fibroma is also rare. We describe a unique case of congenital peripheral developing odontoma accompanied by congenital teratomatous fibroma in an infant. Both tumors were difficult to detect on radiography. Two small masses were seen in the median anterior portion of the palatal mucosa of a 9-month-old boy. The masses had been present since birth and were surgically removed at age 28 months, when one of the masses had grown to a diameter of 8 mm. Histopathologic examination showed a fibrous lesion and a tooth germ-like rounded lesion composed of dental papilla, enamel organ, dentin, and cementum. Although congenital odontoma is rare, it should be considered when selecting appropriate treatment, as early radiographic detection is difficult.

  18. Knowledge Sharing Strategies for Large Complex Building Projects.

    Directory of Open Access Journals (Sweden)

    Esra Bektas

    2013-06-01

    Full Text Available The construction industry is a project-based sector with a myriad of actors such as architects, construction companies, consultants, producers of building materials (Anumba et al., 2005. The interaction between the project partners is often quite limited, which leads to insufficient knowledge sharing during the project and knowledge being unavailable for reuse (Fruchter et al. 2002. The result can be a considerable amount of extra work, delays and cost overruns. Design outcomes that are supposed to function as boundary objects across different disciplines can lead to misinterpretation of requirements, project content and objectives. In this research, knowledge is seen as resulting from social interactions; knowledge resides in communities and it is generated through social relationships (Wenger 1998, Olsson et al. 2008. Knowledge is often tacit, intangible and context-dependent and it is articulated in the changing responsibilities, roles, attitudes and values that are present in the work environment (Bresnen et al., 2003. In a project environment, knowledge enables individuals to solve problems, take decisions, and apply these decisions to actions. In order to achieve a shared understanding and minimize the misunderstanding and misinterpretations among project actors, it is necessary to share knowledge (Fong 2003.Sharing knowledge is particularly crucial in large complex building projects (LCBPs in order to accelerate the building process, improve architectural quality and prevent mistakes or undesirable results. However, knowledge sharing is often hampered through professional or organizational boundaries or contractual concerns. When knowledge is seen as an organizational asset, there is little willingness among project organizations to share their knowledge. Individual people may recognize the need to promote knowledge sharing throughout the project, but typically there is no deliberate strategy agreed by all project partners to address

  19. Discovering large network motifs from a complex biological network

    Energy Technology Data Exchange (ETDEWEB)

    Terada, Aika; Sese, Jun, E-mail: terada@sel.is.ocha.ac.j, E-mail: sesejun@is.ocha.ac.j [Department of Computer Science, Ochanomizu University, 2-1-1 Ohtsuka, Bunkyo-ku, Tokyo 112-8610 (Japan)

    2009-12-01

    Graph structures representing relationships between entries have been studied in statistical analysis, and the results of these studies have been applied to biological networks, whose nodes and edges represent proteins and the relationships between them, respectively. Most of the studies have focused on only graph structures such as scale-free properties and cliques, but the relationships between nodes are also important features since most of the proteins perform their functions by connecting to other proteins. In order to determine such relationships, the problem of network motif discovery has been addressed; network motifs are frequently appearing graph structures in a given graph. However, the methods for network motif discovery are highly restrictive for the application to biological network because they can only be used to find small network motifs or they do not consider noise and uncertainty in observations. In this study, we introduce a new index to measure network motifs called AR index and develop a novel algorithm called ARIANA for finding large motifs even when the network has noise. Experiments using a synthetic network verify that our method can find better network motifs than an existing algorithm. By applying ARIANA to a real complex biological network, we find network motifs associated with regulations of start time of cell functions and generation of cell energies and discover that the cell cycle proteins can be categorized into two different groups.

  20. CAD Method to Design Complex Dobby Weaves with Large Repeats

    Institute of Scientific and Technical Information of China (English)

    祝成炎

    2001-01-01

    The principle of a CAD method of converting the pre-designed figures in image form into complex dobby weaves with the appearances similar to the original figures is mainly introduced in this paper. A few designed weaves by the created CAD system are also given as examples of the practical application in the area of complex dobby weave designing.

  1. Glycan complexity dictates microbial resource allocation in the large intestine

    Science.gov (United States)

    Rogowski, Artur; Briggs, Jonathon A.; Mortimer, Jennifer C.; Tryfona, Theodora; Terrapon, Nicolas; Lowe, Elisabeth C.; Baslé, Arnaud; Morland, Carl; Day, Alison M.; Zheng, Hongjun; Rogers, Theresa E.; Thompson, Paul; Hawkins, Alastair R.; Yadav, Madhav P.; Henrissat, Bernard; Martens, Eric C.; Dupree, Paul; Gilbert, Harry J.; Bolam, David N.

    2015-01-01

    The structure of the human gut microbiota is controlled primarily through the degradation of complex dietary carbohydrates, but the extent to which carbohydrate breakdown products are shared between members of the microbiota is unclear. We show here, using xylan as a model, that sharing the breakdown products of complex carbohydrates by key members of the microbiota, such as Bacteroides ovatus, is dependent on the complexity of the target glycan. Characterization of the extensive xylan degrading apparatus expressed by B. ovatus reveals that the breakdown of the polysaccharide by the human gut microbiota is significantly more complex than previous models suggested, which were based on the deconstruction of xylans containing limited monosaccharide side chains. Our report presents a highly complex and dynamic xylan degrading apparatus that is fine-tuned to recognize the different forms of the polysaccharide presented to the human gut microbiota. PMID:26112186

  2. Peripheral developing odontoma in newborn. Report of two cases and literature review.

    Science.gov (United States)

    Silva, Alan-Roger S; Carlos-Bregni, Roman; Vargas, Pablo-Agustin; de Almeida, Oslei-Paes; Lopes, Marcio-Ajudarte

    2009-11-01

    Extra-osseous odontogenic tumors are rarely observed. However, it is widely accepted that the remains of odontogenic epithelium entrapped in the oral soft tissues may be a possible source for peripheral odontogenic tumors differentiation. Peripheral developing odontoma is considered exceptionally rare, since few similar cases are described in the English-related literature under diverse nomenclature, such as irregular eruption, ectopic tooth, ectopic soft-tissue mesiodens, ectopic odontoma and extra-osseous tooth germ. Previously reported cases invariably affected children and surgical exploration revealed tooth germs exclusively embedded in the soft tissue without bone involvement. Microscopically, all these cases exhibited developing tooth germs composed of ameloblasts, enamel matrix, odontoblastic layer, dentin and dental papilla and the morphological findings seem to depend on the developmental stage of each tooth germ at discovery. Thus, we believe that it is relevant to report two additional cases that were recently diagnosed in Brazil and Guatemala, focusing on their nomenclature, correct diagnosis and further treatment.

  3. Odontoma complexo de grande proporção em ramo mandibular: relato de caso

    Directory of Open Access Journals (Sweden)

    Willian Ricardo Pires

    Full Text Available INTRODUÇÃO: O odontoma é o tumor odontogênico mais comum, sendo considerado também como hamartoma. Sua classificação é baseada na morfologia apresentada, podendo ser classificado como composto, quando apresenta múltiplos dentículos, ou complexo, no caso de uma massa disforme. São geralmente diagnosticados em exames radiográficos de rotina e associados ao atraso no irrompimento dentário. OBJETIVO: Revisar a literatura acerca desse tipo de tumor odontogênico, bem como relatar o caso clínico de um paciente portador de odontoma complexo de grandes proporções envolvendo a região de ramo mandibular.

  4. Bilateral Cystic Lesions Associated to Maxillary Erupted Dilated Odontomas: A Case Report

    Directory of Open Access Journals (Sweden)

    Mahmoodi A.

    2012-06-01

    Full Text Available The term ‘Dilated Odontoma’ is a malformation which most frequently occurs in the deciduous, permanent or supernumerary teeth. It can be diagnosed with deep invagination of the enamel inside the crown or root. In other words, the most extreme form of dens in the dente is known as “dilated odontoma”.Although dilated odontomas are usually asymptomatic, their eruption into the mouth can give rise to pain, inflammation, and infection.This report is an attempt to describe the case of a 22-year-old female presenting with bilateral cystic lesions associated with erupted dilated odontomas of the maxilla.The patient had no history of pain but she complained about a recurrent swelling which she was suffering from for about two years. Conventional radiographs showed bilateral cystic lesions associated with dilated odontomas. The findings were also confirmed by Dent Scan. The treatment plan consisted of surgical removal of the lesions, followed by histopathologic study in order to confirm the initial diagnosis.

  5. Data mining in large sets of complex data

    CERN Document Server

    Cordeiro, Robson L F; Júnior, Caetano Traina

    2013-01-01

    The amount and the complexity of the data gathered by current enterprises are increasing at an exponential rate. Consequently, the analysis of Big Data is nowadays a central challenge in Computer Science, especially for complex data. For example, given a satellite image database containing tens of Terabytes, how can we find regions aiming at identifying native rainforests, deforestation or reforestation? Can it be made automatically? Based on the work discussed in this book, the answers to both questions are a sound "yes", and the results can be obtained in just minutes. In fact, results that

  6. Quiste de Gorlin asociado a Odontoma: reporte de un caso con su tratamiento quirúrgico Gorlin cyst associated with odontoma: Case report with surgical treatment

    Directory of Open Access Journals (Sweden)

    P. Villarroel Castro

    2005-12-01

    Full Text Available El quiste de Gorlin es un quiste odontogénico que puede presentarse en dos variedades, una quística rodeada por epitelio y de carácter benigno, y una neoplásica localmente agresiva. Se presenta elcaso de una mujer de 18 años con aumento de volumen facial indoloro en región infraorbitaria izquierda. Se realiza la exéresis total de la lesión. Con el estudio histopatológico se obtiene el diagnóstico definitivo de quiste de Gorlin asociado a odontoma. Luego de controles por 3 años, se observa el restablecimiento de la simetría facial, una adecuada regeneración ósea y de los tejidos adyacentes, sin signos de recidiva.Gorlin cyst is an odontogenic cyst that may appear as two types, one cystic and surrounded by epithelium of a benign nature, and the other a locally aggressive neoplasm. The case is presented of an 18-year-old female that had experienced an increase in facial volume in the left infraorbital area that was painless. Total exeresis of the lesion was carried out. The histopathologic study provided the definitive diagnosis of Gorlin cyst associated with odontoma. After a follow-up of three years, facial symmetry was reestablished, there was adequate regeneration of bone and of the adjacent tissue, and there were no signs of relapse.

  7. Reliability analysis of large, complex systems using ASSIST

    Science.gov (United States)

    Johnson, Sally C.

    1988-01-01

    The SURE reliability analysis program is discussed as well as the ASSIST model generation program. It is found that semi-Markov modeling using model reduction strategies with the ASSIST program can be used to accurately solve problems at least as complex as other reliability analysis tools can solve. Moreover, semi-Markov analysis provides the flexibility needed for modeling realistic fault-tolerant systems.

  8. The complexity nature of large-scale software systems

    Institute of Scientific and Technical Information of China (English)

    Yan Dong; Qi Guo-Ning; Gu Xin-Jian

    2006-01-01

    In software engineering, class diagrams are often used to describe the system's class structures in Unified Modelling Language (UML). A class diagram, as a graph, is a collection of static declarative model elements, such as classes, interfaces, and the relationships of their connections with each other. In this paper, class graphs are examined within several Java software systems provided by Sun and IBM, and some new features are found. For a large-scale Java software system, its in-degree distribution tends to an exponential distribution, while its out-degree and degree distributions reveal the power-law behaviour. And then a directed preferential-random model is established to describe the corresponding degree distribution features and evolve large-scale Java software systems.

  9. Multi-Path Guided Wave Imaging for Inspection and Monitoring of Large, Complex Structures Project

    Data.gov (United States)

    National Aeronautics and Space Administration — There is a well-recognized need within NASA and the aerospace community at large for rapid and reliable methods for inspection of large, complex structures. This...

  10. A Renewed Approach for Large Eddy Simulation of Complex Geometries Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The potential benefits of Large Eddy Simulation (LES) for aerodynamics and combustion simulation hvae largely been missed, due to the complexity of generating grids...

  11. Large-eddy simulation of atmospheric flow over complex terrain

    Energy Technology Data Exchange (ETDEWEB)

    Bechmann, A.

    2006-11-15

    The present report describes the development and validation of a turbulence model designed for atmospheric flows based on the concept of Large-Eddy Simulation (LES). The background for the work is the high Reynolds number k - epsilon model, which has been implemented on a finite-volume code of the incompressible Reynolds-averaged Navier-Stokes equations (RANS). The k - epsilon model is traditionally used for RANS computations, but is here developed to also enable LES. LES is able to provide detailed descriptions of a wide range of engineering flows at low Reynolds numbers. For atmospheric flows, however, the high Reynolds numbers and the rough surface of the earth provide difficulties normally not compatible with LES. Since these issues are most severe near the surface they are addressed by handling the near surface region with RANS and only use LES above this region. Using this method, the developed turbulence model is able to handle both engineering and atmospheric flows and can be run in both RANS or LES mode. For LES simulations a time-dependent wind field that accurately represents the turbulent structures of a wind environment must be prescribed at the computational inlet. A method is implemented where the turbulent wind field from a separate LES simulation can be used as inflow. To avoid numerical dissipation of turbulence special care is paid to the numerical method, e.g. the turbulence model is calibrated with the specific numerical scheme used. This is done by simulating decaying isotropic and homogeneous turbulence. Three atmospheric test cases are investigated in order to validate the behavior of the presented turbulence model. Simulation of the neutral atmospheric boundary layer, illustrates the turbulence model ability to generate and maintain the turbulent structures responsible for boundary layer transport processes. Velocity and turbulence profiles are in good agreement with measurements. Simulation of the flow over the Askervein hill is also

  12. Large-eddy simulation of atmospheric flow over complex terrain

    DEFF Research Database (Denmark)

    Bechmann, Andreas

    2007-01-01

    layer transport processes. Velocity and turbulence profiles are in good agreement with measurements. Simulation of the flow over the Askervein hill is also performed. Speed-up and turbulence intensities show good agreement with measurements, except 400m downstream of the hill summit where speed......The present report describes the development and validation of a turbulence model designed for atmospheric flows based on the concept of Large-Eddy Simulation (LES). The background for the work is the high Reynolds number k - #epsilon# model, which has been implemented on a finite-volume code...... turbulence model is able to handle both engineering and atmospheric flows and can be run in both RANS or LES mode. For LES simulations a time-dependent wind field that accurately represents the turbulent structures of a wind environment must be prescribed at the computational inlet. A method is implemented...

  13. Calcifying cystic odontogenic tumor associated with ameloblastic fibro-odontoma of the anterior mandible.

    Science.gov (United States)

    Lee, Jun; Song, Young-Gook; Moon, Seong-Yong; Choi, Boyoung; Kim, Bong Chul; Yoon, Jung-Hoon

    2014-05-01

    Calcifying cystic odontogenic tumor, which was formerly named calcifying odontogenic cyst, is a benign odontogenic tumor containing clusters of ghost cells within ameloblastic epithelium. Calcifying cystic odontogenic tumors have been associated with other odontogenic tumors, a finding that is a rare event in other types of odontogenic cysts or tumors. This report describes a case of hybrid odontogenic tumor composed of calcifying cystic odontogenic tumor and ameloblastic fibroma-odontoma of the anterior mandible that occurred in a 4-year-old Korean girl.

  14. Ameloblastic fibro-odontoma of the anterior mandible in a 22-month-old boy.

    Science.gov (United States)

    Wewel, John; Narayana, Nagamani

    2010-01-01

    We report an ameloblastic fibro-odontoma (AFO) presenting in the anterior mandible as a "bump on his gums" in a 22-month-old boy. An occlusal radiograph revealed a well-circumscribed radiolucency with scattered radiopaque foci. The tumor was enucleated under general anesthesia. The histologic findings were characteristic of an AFO, a mixed odontogenic tumor most common in the posterior jaws, primarily affecting individuals with an average age of 10 years. The clinical presentation, microscopic findings, differential diagnoses, and treatment are discussed.

  15. Ameloblastic fibro-odontoma of the anterior mandible in a 22-month-old boy

    Directory of Open Access Journals (Sweden)

    Wewel John

    2010-01-01

    Full Text Available We report an ameloblastic fibro-odontoma (AFO presenting in the anterior mandible as a "bump on his gums" in a 22-month-old boy. An occlusal radiograph revealed a well-circumscribed radiolucency with scattered radiopaque foci. The tumor was enucleated under general anesthesia. The histologic findings were characteristic of an AFO, a mixed odontogenic tumor most common in the posterior jaws, primarily affecting individuals with an average age of 10 years. The clinical presentation, microscopic findings, differential diagnoses, and treatment are discussed.

  16. Ectopic Compound Odontoma in the Buccal Mucosa: Report of a Rare Case

    Directory of Open Access Journals (Sweden)

    Aparna Venigalla

    2015-01-01

    Full Text Available Eruption of tooth into extraosseous locations is an extremely rare condition. We report a case of a six-year-old girl child with tooth-like structure erupting from the right buccal mucosa. Clinical, radiographic, and histopathologic examination suggested the diagnosis of compound odontoma. Very few cases have been reported so far, where tooth has been located completely in the soft tissue and a variety of names have been used for that condition. A brief review of the literature and the ambiguity in naming the situation is discussed.

  17. Ectopic compound odontoma in the buccal mucosa: report of a rare case.

    Science.gov (United States)

    Venigalla, Aparna; Guttikonda, Leela Krishna; Nelakurthi, Hasini; Babburi, Suresh; Pinisetti, Soujanya; Kotti, Ajay Banerji; Kalapala, Lavanya

    2015-01-01

    Eruption of tooth into extraosseous locations is an extremely rare condition. We report a case of a six-year-old girl child with tooth-like structure erupting from the right buccal mucosa. Clinical, radiographic, and histopathologic examination suggested the diagnosis of compound odontoma. Very few cases have been reported so far, where tooth has been located completely in the soft tissue and a variety of names have been used for that condition. A brief review of the literature and the ambiguity in naming the situation is discussed.

  18. Odontoma compuesto: Diagnóstico radiográfico y tratamiento quirúrgico de un caso clínico Compound odontoma: Radiographic diagnosis and surgical management of a clinical case

    Directory of Open Access Journals (Sweden)

    J. Vázquez Diego

    2008-10-01

    Full Text Available Se presenta un caso clínico de odontoma compuesto asociado a un diente supernumerario y un canino retenido superior derecho. El paciente de 16 años de edad es de sexo masculino. Se realizan diversos estudios radiográficos para su diagnóstico, que consisten en técnica panorámica y técnicas intraorales. Posteriormente se realizó la intervención quirúrgica para extirpar la lesión y las estructuras dentarias asociadas a ella. El estudio histopatológico confirmó el diagnóstico presuntivo. Basado en lo expuesto se analiza al odontoma compuesto según localización, sexo y edad habiendo realizado una revisión del tema según diversos autores.A clinical case of a compound odontoma associated with a supernumerary tooth and an upper right impacted canine in a 16-year-old male, is reported. To perform the diagnosis, several radiographic studies were made, mainly consisting of panoramic and intraoral techniques. Then, a surgical procedure was carried out to remove both the lesion and the surrounding tooth structures. The histo-pathological examination confirmed our presumptive diagnosis. Therefore, based on these findings, the compound odontoma is analyzed according to its location, sex and age of patients as well, after reviewing other authors´ opinions in the current literature.

  19. LEGO-NMR spectroscopy: a method to visualize individual subunits in large heteromeric complexes.

    Science.gov (United States)

    Mund, Markus; Overbeck, Jan H; Ullmann, Janina; Sprangers, Remco

    2013-10-18

    Seeing the big picture: Asymmetric macromolecular complexes that are NMR active in only a subset of their subunits can be prepared, thus decreasing NMR spectral complexity. For the hetero heptameric LSm1-7 and LSm2-8 rings NMR spectra of the individual subunits of the complete complex are obtained, showing a conserved RNA binding site. This LEGO-NMR technique makes large asymmetric complexes accessible to detailed NMR spectroscopic studies.

  20. Long-term culture of human odontoma-derived cells with a Rho kinase inhibitor.

    Science.gov (United States)

    Uzawa, Katsuhiro; Kasamatsu, Atsushi; Saito, Tomoaki; Takahara, Toshikazu; Minakawa, Yasuyuki; Koike, Kazuyuki; Yamatoji, Masanobu; Nakashima, Dai; Higo, Morihiro; Sakamoto, Yosuke; Shiiba, Masashi; Tanzawa, Hideki

    2016-09-10

    Because of cellular senescence/apoptosis, no effective culture systems are available to maintain replication of cells from odontogenic tumors especially for odontoma, and, thus, the ability to isolate human odontoma-derived cells (hODCs) for functional studies is needed. The current study was undertaken to develop an approach to isolate hODCs and fully characterize the cells in vitro. The hODCs were cultured successfully with a Rho-associated protein kinase inhibitor (Y-27632) for an extended period with stabilized lengths of the telomeres to sustain a similar phenotype/property as the primary tumoral cells. While the hODCs showed stable long-term expansion with expression of major dental epithelial markers including dentin sialophosphoprotein (DSPP) even in the three-dimensional microenvironment, they lack the specific markers for the characteristics of stem cells. Moreover, cells from dental pulp showed significant up-regulation of DSPP when co-cultured with the hODCs, while control fibroblasts with the hODCs did not. Taken together, we propose that the hODCs can be isolated and expanded over the long term with Y-27632 to investigate not only the development of the hODCs but also other types of benign human tumors.

  1. Different Evolutionary Paths to Complexity for Small and Large Populations of Digital Organisms

    Science.gov (United States)

    2016-01-01

    A major aim of evolutionary biology is to explain the respective roles of adaptive versus non-adaptive changes in the evolution of complexity. While selection is certainly responsible for the spread and maintenance of complex phenotypes, this does not automatically imply that strong selection enhances the chance for the emergence of novel traits, that is, the origination of complexity. Population size is one parameter that alters the relative importance of adaptive and non-adaptive processes: as population size decreases, selection weakens and genetic drift grows in importance. Because of this relationship, many theories invoke a role for population size in the evolution of complexity. Such theories are difficult to test empirically because of the time required for the evolution of complexity in biological populations. Here, we used digital experimental evolution to test whether large or small asexual populations tend to evolve greater complexity. We find that both small and large—but not intermediate-sized—populations are favored to evolve larger genomes, which provides the opportunity for subsequent increases in phenotypic complexity. However, small and large populations followed different evolutionary paths towards these novel traits. Small populations evolved larger genomes by fixing slightly deleterious insertions, while large populations fixed rare beneficial insertions that increased genome size. These results demonstrate that genetic drift can lead to the evolution of complexity in small populations and that purifying selection is not powerful enough to prevent the evolution of complexity in large populations. PMID:27923053

  2. Large-N phase transitions in the spectrum of products of complex matrices

    CERN Document Server

    Lohmayer, R; Wettig, T

    2008-01-01

    It is shown that the simplest multiplicative random complex matrix model generalizes the large-N phase structure found in the unitary case: A perturbative regime is joined to a nonperturbative regime at a point of nonanalyticity.

  3. Characterizing the Sample Complexity of Large-Margin Learning With Second-Order Statistics

    CERN Document Server

    Sabato, Sivan; Tishby, Naftali

    2012-01-01

    We obtain a tight distribution-specific characterization of the sample complexity of large-margin classification with L_2 regularization: We introduce the margin-adapted dimension, which is a simple function of the second order statistics of the data distribution, and show distribution-specific upper and lower bounds on the sample complexity, both governed by the margin-adapted dimension of the data distribution. The upper bounds are universal, and the lower bounds hold for a rich family of sub-Gaussian distributions. We conclude that this new quantity tightly characterizes the true sample complexity of large-margin classification.

  4. Ameloglastic fibro-odontoma with a change of calcifying odontogenic cyst

    Energy Technology Data Exchange (ETDEWEB)

    Kwon, Hyuk Rok; Han, Jin Woo; Lee, Jin Ho; Choi, Hang Moon; Park, In Woo; Lee, Suk Keun [Kangnung National Univ., Kangnung (Korea, Republic of)

    2001-09-15

    Thirteen-year-old girl complaining of the swelling and pain on the left midface visited our dental hospital. On the radiographic examination, well-defined radiolucent lesion with hyperostotic border was found in the left maxilla accompanying with the external root resorption of the involved teeth and the displaced second molar. CT showed calcified bodies, thinning of hard palate, inferior orbital wall and lateral wall of nasal fossa, and thinning and perforation of the buccal plate of the maxilla. Enucleation and curettage of the lesion and nasoantrostomy was carried out and histopathologic examination mainly showed a solid tumor tissue composed of odontogenic epithelium and pulp tissues admixed with dentin and enamel formation. And some part of reduced follicular epithelium of tooth germ showed a change mimicking calcifying odontogenic cyst. Taken together, we concluded the lesion is an ameloblastic fibro-odontoma with as change of calcifying odontogenic cyst.

  5. Ameloblastic fibro-odontoma associated with a retained molar in an Oldenburg mare.

    Science.gov (United States)

    Knowles, Susan; Blas-Machado, Uriel; Butler, Abigail M; Gomez-Ibañez, Sara E; Lowder, Michael Q; Fayrer-Hosken, Richard A

    2010-11-01

    An 11-year-old Oldenburg mare presented with a 3-month history of weight loss and swelling of the posterior right mandible. Physical examination and radiographs showed a soft-tissue mass in the right mandible with foci of mineralization, periosteal proliferation, and a retained molar. The tumor increased in size over several weeks, and the mare was euthanized. On necropsy, a 24 cm × 15 cm × 15 cm firm, white mass had obliterated the posterior right mandible. The mass was multinodular with discrete clusters of blood-filled cystic spaces. Histologically, the mass was composed of neoplastic odontogenic epithelium and pulpal mesenchyme with an accumulation of eosinophilic material resembling dentin or enamel. Microscopic and immunohistochemical staining features of the neoplasm were most consistent with an ameloblastic fibro-odontoma.

  6. Ghost cell odontogenic tumor associated with odontoma--report of two rare cases.

    Science.gov (United States)

    Hogge, Maritzabel; Velez, Ines; Kaltman, Steven; Movahed, Reza; Yeh, Frank

    2012-01-01

    The ghost cell odontogenic tumor (GCOT) is a neoplastic/cystic lesion with a diverse histopathological and clinical behavior It was formerly known as calcified odontogenic cyst, but in 2005 the World Health Organization categorized this lesion as an odontogenic, benign tumor rather than a cyst; nominating this neoplasm as calcifying cystic odontogenic tumor. A later comprehensive classification named it ghost cell odontogenic tumor because the most remarkable histopathologic characteristic is the presence of a mass of ghost cells embedded in the epithelium. We report two cases of a rare variant of a ghost cell odontogenic tumor associated with odontoma; to our knowledge, one is the youngest patient (four month old) reported in the English literature.

  7. Post-Odontoma autotransplantation of an impacted tooth: A case report.

    Science.gov (United States)

    Robindro Singh, Waikhom; Aheibam, Kirankumar; Nameirakpam, Anthopia

    2015-01-01

    After years of relegation by dental implants, autotransplantation has recently become more popular because of a better understanding of its science. The prognosis of autotransplantation primarily depends upon the presence of an intact alveolar bone at the transplant site and the regeneration of a functional periodontal ligament of the transplant. Replacement of an unsalvaged or a missing tooth by a natural tooth with normal periodontium within a short duration of treatment is the ultimate challenge of autotransplantation. Meanwhile, Platelet Rich Fibrin (PRF) is popular as a biomaterial which helps in the regeneration of bone and periodontal tissues. To improve the prognosis, and also shorten the treatment time in a rare case of autotransplantation of an impacted tooth in a post-odontoma site, we did a two-stage surgical procedure aided by synthetic bone granules (Biograft) and PRF. The clinical and radiological findings at 6 months follow-up showed good result and promise.

  8. A peripheral ameloblastic fibro-odontoma in a 3-year-old girl: case report, immunohistochemical analysis, and literature review.

    Science.gov (United States)

    Lin, Yi-Chun; Hsu, Hsiu-Ming; Liu, Chiang-Shin; Yuan, Kuo

    2014-01-01

    Ameloblastic fibro-odontoma (AFO) predominantly occurs in the jaw bones of children and young adults. Extraosseous AFO is extremely rare. We describe a peripheral ameloblastic fibro-odontoma in the maxillary gingiva of a 3-year-old girl. The clinical appearance resembled fiery red reactive gingival lesions. The histopathological examination of the excised lesion showed small islands and cords of odontogenic epithelium with cellular myxoid stroma in the subepithelial tissue. The mass contained calcified material and an enamel-like deposit. Many small blood vessels appeared in the connective tissue surrounding the odontogenic epithelium. The immunohistochemical assays showed strong reactivity for amelogenin, β-catenin, CD44, and CD31 in the tissue sections. There was no recurrence after the 1-year follow-up. Because this lesion clinically resembles other nonneoplastic lesions and is very rare in gingiva, establishing a correct diagnosis is achieved only based on specific histological characteristics. Conservative excision of the tumor is the treatment of choice.

  9. A pigmented calcifying cystic odontogenic tumor associated with compound odontoma: a case report and review of literature

    Directory of Open Access Journals (Sweden)

    Borkosky Silvia S

    2007-09-01

    Full Text Available Abstract Background Pigmented intraosseous odontogenic lesions are rare with only 47 reported cases in the English literature. Among them, pigmented calcifying cystic odontogenic tumor, formerly known as calcifying odontogenic cyst, is the most common lesion with 20 reported cases. Methods A case of pigmented calcifying cystic odontogenic tumor associated with odontoma occurring at the mandibular canine-premolar region of a young Japanese boy is presented with radiographic, and histological findings. Special staining, electron microscopic study and immunohistochemical staining were also done to characterize the pigmentation. Results The pigments in the lesion were confirmed to be melanin by Masson-Fontana staining and by transmission electron microscopy. The presence of dendritic melanocytes within the lesion was also demonstrated by S-100 immunostaining. Conclusion The present case report of pigmented calcifying cystic odontogenic tumor associated with odontoma features a comprehensive study on melanin and melanocytes, including histochemical, immunohistochemical and transmission electron microscopic findings.

  10. Revascularization of an impacted, immature dilacerated permanent maxillary central incisor associated with odontoma and a supernumerary tooth

    Directory of Open Access Journals (Sweden)

    Priya Subramaniam

    2013-01-01

    Full Text Available To intentionally replant an impacted immature permanent maxillary central incisor in the mixed dentition period followed by revascularization in order to achieve apical root closure. A 9-year-old boy presented with retained maxillary left primary incisors. Radiographic evaluation revealed the presence of a supernumerary tooth and an odontoma associated with an impacted permanent maxillary left central incisor, having root dilaceration. Treatment included surgical removal of mesiodens and odontoma. The impacted dilacerated permanent central incisor was removed and intentionally replanted, followed by revascularization of pulp. During the follow-up, root end closure with narrowing of canal space was observed, patient has been asymptomatic and the tooth remains vital. Revascularization of the immature reimplanted tooth showed continued root development and thickening of the lateral dentinal walls through deposition of new hard tissue and narrowing of the canal space.

  11. Large-scale modeling - a tool for conquering the complexity of the brain

    Directory of Open Access Journals (Sweden)

    Mikael Djurfeldt

    2008-04-01

    Full Text Available Is there any hope of achieving a thorough understanding of higher functions such as perception, memory, thought and emotion or is the stunning complexity of the brain a barrier which will limit such efforts for the foreseeable future? In this perspective we discuss methods to handle complexity, approaches to model building, and point to detailed large-scale models as a new contribution to the toolbox of the computational neuroscientist. We elucidate some aspects which distinguishes large-scale models and some of the technological challenges which they entail.

  12. Task Phase Recognition for Highly Mobile Workers in Large Building Complexes

    DEFF Research Database (Denmark)

    Stisen, Allan; Mathisen, Andreas; Krogh, Søren

    2016-01-01

    available for sensing and recognizing the activities and task phases the workers currently perform as such technologies have to be easily deployable and maintainable at a large scale. The methods presented in this paper consist of features that utilize data from sensing systems which are common in large......Being aware of activities of co-workers is a basic and vital mechanism for efficient work in highly distributed work settings. Thus, automatic recognition of the task phases the mobile workers are currently (or have been) in has many applications, e.g., efficient coordination of tasks...... by visualizing coworkers’ task progress, automatic notifications based on context awareness, and record filing of task statuses and completions. This paper presents methods to sense and detect highly mobile workers’ tasks phases in large building complexes. Large building complexes restrict the technologies...

  13. Decentralized and overall condition monitoring system for large-scale mobile and complex equipment

    Institute of Scientific and Technical Information of China (English)

    Cao Jianjun; Zhang Peilin; Ren Guoquan; Fu Jianping

    2007-01-01

    It is an urgent project to realize online and overall condition monitoring and timely fault diagnosis for large-scale mobile and complex equipment. Moreover, most of the existing large-scale complex equipment has quite insufficient accessibility of examination, although it still has quite a long service life. The decentralized and overall condition monitoring, as a new concept, is proposed from the point of view of the whole system. A set of complex equipment is divided into several parts in terms of concrete equipment. Every part is processed via one detecting unit, and the main detecting unit is connected with other units. The management work and communications with the remote monitoring center have been taken on by it. Consequently, the difficulty of realizing a condition monitoring system and the complexity of processing information is reduced greatly. Furthermore, excellent maintainability of the condition monitoring system is obtained because of the modularization design. Through an application example,the design and realization of the decentralized and overall condition monitoring system is introduced specifically.Some advanced technologies, such as, micro control unit (MCU), advanced RISC machines (ARM), and control area network (CAN), have been adopted in the system. The system's applicability for the existing large-scale mobile and complex equipment is tested.

  14. An Improved Conceptually-Based Method for Analysis of Communication Network Structure of Large Complex Organizations.

    Science.gov (United States)

    Richards, William D., Jr.

    Previous methods for determining the communication structure of organizations work well for small or simple organizations, but are either inadequate or unwieldy for use with large complex organizations. An improved method uses a number of different measures and a series of successive approximations to order the communication matrix such that…

  15. Software quality assurance: in large scale and complex software-intensive systems

    NARCIS (Netherlands)

    Mistrik, I.; Soley, R.; Ali, N.; Grundy, J.; Tekinerdogan, B.

    2015-01-01

    Software Quality Assurance in Large Scale and Complex Software-intensive Systems presents novel and high-quality research related approaches that relate the quality of software architecture to system requirements, system architecture and enterprise-architecture, or software testing. Modern software

  16. Defining Execution Viewpoints for a Large and Complex Software-Intensive System

    NARCIS (Netherlands)

    Callo Arias, Trosky B.; America, Pierre; Avgeriou, Paris

    2009-01-01

    An execution view is an important asset for developing large and complex systems. An execution view helps practitioners to describe, analyze, and communicate what a software system does at runtime and how it does it. In this paper, we present an approach to define execution viewpoints for an existin

  17. Software quality assurance: in large scale and complex software-intensive systems

    NARCIS (Netherlands)

    Mistrik, I.; Soley, R.; Ali, N.; Grundy, J.; Tekinerdogan, B.

    2015-01-01

    Software Quality Assurance in Large Scale and Complex Software-intensive Systems presents novel and high-quality research related approaches that relate the quality of software architecture to system requirements, system architecture and enterprise-architecture, or software testing. Modern software

  18. Estimation of effects of quantitative trait loci in large complex pedigrees

    NARCIS (Netherlands)

    Meuwissen, T.H.E.; Goddard, M.E.

    1997-01-01

    A method was derived to estimate effects of quantitative trait loci (QTL) using incomplete genotype information in large outbreeding populations with complex pedigrees. The method accounts for background genes by estimating polygenic effects. The basic equations used are very similar to the usual li

  19. Par@Graph - a parallel toolbox for the construction and analysis of large complex climate networks

    NARCIS (Netherlands)

    Tantet, A.J.J.

    2015-01-01

    In this paper, we present Par@Graph, a software toolbox to reconstruct and analyze complex climate networks having a large number of nodes (up to at least 106) and edges (up to at least 1012). The key innovation is an efficient set of parallel software tools designed to leverage the inherited hybrid

  20. Ultra Low Complexity Soft Output Detector for Non-Binary LDPC Coded Large MIMO Systems

    CERN Document Server

    Suthisopapan, Puripong; Kasai, Kenta; Imtawil, Virasit

    2012-01-01

    The theoretic results of MIMO capacity tell us that the higher the number of antennas are employed, the higher the transmission rate is. This makes MIMO systems with hundreds of antennas very attractive but one of the major problems that obstructs such large dimensional MIMO systems from the practical realization is a high complexity of the MIMO detector. We present in this paper the new soft output MIMO detector based on matched filtering that can be applied to the large MIMO systems which are coded by the powerful non-binary LDPC codes. The per-bit complexity of the proposed detector is just 0.28% to that of low complexity soft output MMSE detector and scales only linearly with a number of antennas. Furthermore, the coded performances with small information length 800 bits are within 4.2 dB from the associated MIMO capacity.

  1. Etoile Project : Social Intelligent ICT-System for very large scale education in complex systems

    Science.gov (United States)

    Bourgine, P.; Johnson, J.

    2009-04-01

    The project will devise new theory and implement new ICT-based methods of delivering high-quality low-cost postgraduate education to many thousands of people in a scalable way, with the cost of each extra student being negligible (students studying courses in complex systems. This community is chosen because it is large and interdisciplinary and there is a known requirement for courses for thousand of students across Europe. The project involves every aspect of course production and delivery. Within this the research focused on the creation of a Socially Intelligent Resource Mining system to gather large volumes of high quality educational resources from the internet; new methods to deconstruct these to produce a semantically tagged Learning Object Database; a Living Course Ecology to support the creation and maintenance of evolving course materials; systems to deliver courses; and a ‘socially intelligent assessment system'. The system will be tested on one to ten thousand postgraduate students in Europe working towards the Complex System Society's title of European PhD in Complex Systems. Étoile will have a very high impact both scientifically and socially by (i) the provision of new scalable ICT-based methods for providing very low cost scientific education, (ii) the creation of new mathematical and statistical theory for the multiscale dynamics of complex systems, (iii) the provision of a working example of adaptation and emergence in complex socio-technical systems, and (iv) making a major educational contribution to European complex systems science and its applications.

  2. Spatiotemporal Chaos in Large Systems The Scaling of Complexity with Size

    CERN Document Server

    Greenside, H S

    1996-01-01

    The dynamics of a nonequilibrium system can become complex because the system has many components (e.g., a human brain), because the system is strongly driven from equilibrium (e.g., large Reynolds-number flows), or because the system becomes large compared to certain intrinsic length scales. Recent experimental and theoretical work is reviewed that addresses this last route to complexity. In the idealized case of a sufficiently large, nontransient, homogeneous, and chaotic system, the fractal dimension D becomes proportional to the system's volume V which defines the regime of extensive chaos. The extensivity of the fractal dimension suggests a new way to characterize correlations in high-dimensional systems in terms of an intensive dimension correlation length $\\xi_\\delta$. Recent calculations at Duke University show that $\\xi_\\delta$ is a length scale smaller than and independent of some commonly used measures of disorder such as the two-point and mutual-information correlation lengths. Identifying the bas...

  3. Development and implementation of an algorithm for detection of protein complexes in large interaction networks

    Directory of Open Access Journals (Sweden)

    Kanaya Shigehiko

    2006-04-01

    Full Text Available Abstract Background After complete sequencing of a number of genomes the focus has now turned to proteomics. Advanced proteomics technologies such as two-hybrid assay, mass spectrometry etc. are producing huge data sets of protein-protein interactions which can be portrayed as networks, and one of the burning issues is to find protein complexes in such networks. The enormous size of protein-protein interaction (PPI networks warrants development of efficient computational methods for extraction of significant complexes. Results This paper presents an algorithm for detection of protein complexes in large interaction networks. In a PPI network, a node represents a protein and an edge represents an interaction. The input to the algorithm is the associated matrix of an interaction network and the outputs are protein complexes. The complexes are determined by way of finding clusters, i. e. the densely connected regions in the network. We also show and analyze some protein complexes generated by the proposed algorithm from typical PPI networks of Escherichia coli and Saccharomyces cerevisiae. A comparison between a PPI and a random network is also performed in the context of the proposed algorithm. Conclusion The proposed algorithm makes it possible to detect clusters of proteins in PPI networks which mostly represent molecular biological functional units. Therefore, protein complexes determined solely based on interaction data can help us to predict the functions of proteins, and they are also useful to understand and explain certain biological processes.

  4. Influence of the large-small split effect on strategy choice in complex subtraction.

    Science.gov (United States)

    Xiang, Yan Hui; Wu, Hao; Shang, Rui Hong; Chao, Xiaomei; Ren, Ting Ting; Zheng, Li Ling; Mo, Lei

    2016-03-31

    Two main theories have been used to explain the arithmetic split effect: decision-making process theory and strategy choice theory. Using the inequality paradigm, previous studies have confirmed that individuals tend to adopt a plausibility-checking strategy and a whole-calculation strategy to solve large and small split problems in complex addition arithmetic, respectively. This supports strategy choice theory, but it is unknown whether this theory also explains performance in solving different split problems in complex subtraction arithmetic. This study used small, intermediate and large split sizes, with each split condition being further divided into problems requiring and not requiring borrowing. The reaction times (RTs) for large and intermediate splits were significantly shorter than those for small splits, while accuracy was significantly higher for large and middle splits than for small splits, reflecting no speed-accuracy trade-off. Further, RTs and accuracy differed significantly between the borrow and no-borrow conditions only for small splits. This study indicates that strategy choice theory is suitable to explain the split effect in complex subtraction arithmetic. That is, individuals tend to choose the plausibility-checking strategy or the whole-calculation strategy according to the split size. © 2016 International Union of Psychological Science.

  5. How Project Managers Really Manage: An Indepth Look at Some Managers of Large, Complex NASA Projects

    Science.gov (United States)

    Mulenburg, Gerald M.; Impaeilla, Cliff (Technical Monitor)

    2000-01-01

    This paper reports on a research study by the author that examined ten contemporary National Aeronautics and Space Administration (NASA) complex projects. In-depth interviews with the project managers of these projects provided qualitative data about the inner workings of the project and the methodologies used in establishing and managing the projects. The inclusion of a variety of space, aeronautics, and ground based projects from several different NASA research centers helped to reduce potential bias in the findings toward any one type of project, or technical discipline. The findings address the participants and their individual approaches. The discussion includes possible implications for project managers of other large, complex, projects.

  6. Probabilistic SDG model description and fault inference for large-scale complex systems

    Institute of Scientific and Technical Information of China (English)

    Yang Fan; Xiao Deyun

    2006-01-01

    Large-scale complex systems have the feature of including large amount of variables that have complex relationships, for which signed directed graph (SDG) model could serve as a significant tool by describing the causal relationships among variables. Although qualitative SDG expresses the causing effects between variables easily and clearly, it has many disadvantages or limitations. Probabilistic SDG proposed in the article describes deliver relationships among faults and variables by conditional probabilities, which contains more information and performs more applicability. The article introduces the concepts and construction approaches of probabilistic SDG, and presents the inference approaches aiming at fault diagnosis in this framework, i.e. Bayesian inference with graph elimination or junction tree algorithms to compute fault probabilities. Finally, the probabilistic SDG of a typical example of 65t/h boiler system is given.

  7. The Spectra of Type IIB Flux Compactifications at Large Complex Structure

    CERN Document Server

    Brodie, Callum

    2015-01-01

    We compute the spectra of the Hessian matrix, ${\\cal H}$, and the matrix ${\\cal M}$ that governs the critical point equation of the low-energy effective supergravity, as a function of the complex structure and axio-dilaton moduli space in type IIB flux compactifications at large complex structure. We find both spectra analytically in an $h^{1,2}_-+3$ real-dimensional subspace of the moduli space, and show that they exhibit a universal structure with highly degenerate eigenvalues, independently of the choice of flux, the details of the compactification geometry, and the number of complex structure moduli. In this subspace, the spectrum of the Hessian matrix contains no tachyons, but there are also no critical points. We show numerically that the spectra of ${\\cal H}$ and ${\\cal M}$ remain highly peaked over a large fraction of the sampled moduli space of explicit Calabi-Yau compactifications with 2 to 5 complex structure moduli. In these models, the scale of the supersymmetric contribution to the scalar masses...

  8. Parameter and State Estimation of Large-Scale Complex Systems Using Python Tools

    Directory of Open Access Journals (Sweden)

    M. Anushka S. Perera

    2015-07-01

    Full Text Available This paper discusses the topics related to automating parameter, disturbance and state estimation analysis of large-scale complex nonlinear dynamic systems using free programming tools. For large-scale complex systems, before implementing any state estimator, the system should be analyzed for structural observability and the structural observability analysis can be automated using Modelica and Python. As a result of structural observability analysis, the system may be decomposed into subsystems where some of them may be observable --- with respect to parameter, disturbances, and states --- while some may not. The state estimation process is carried out for those observable subsystems and the optimum number of additional measurements are prescribed for unobservable subsystems to make them observable. In this paper, an industrial case study is considered: the copper production process at Glencore Nikkelverk, Kristiansand, Norway. The copper production process is a large-scale complex system. It is shown how to implement various state estimators, in Python, to estimate parameters and disturbances, in addition to states, based on available measurements.

  9. Exodoncia de diente supernumerario, canino en transposición y enucleación de odontoma complejo: Reporte de Caso

    OpenAIRE

    Perea Paz, Miguel; Facultad de Estomatología, Universidad Peruana Cayetano Heredia. Lima,; Aliaga Del Castillo, Rosalinda; Facultad de Estomatología, Universidad Peruana Cayetano Heredia. Lima,; Aliaga Del Castillo, Arón; Facultad de Estomatología, Universidad Peruana Cayetano Heredia. Lima,

    2014-01-01

    Las anomalías dentarias más frecuentes e importantes que afectan a los niños son la presencia de piezas supernumerarias, piezas retenidas y odontomas. Algunos dientes retenidos se pueden encontrar en  transposición. Reportamos el caso de una paciente de sexo femenino de 11 años de edad con presencia de diente supernumerario, canino en transposición y odontoma complejo situados en la hemiarcada derecha del maxilar superior. El motivo de consulta fue por la presencia de dientes anteriores sobre...

  10. Exodoncia de diente supernumerario, canino en transposición y enucleación de odontoma complejo: Reporte de Caso

    OpenAIRE

    Perea Paz, Miguel; Facultad de Estomatología, Universidad Peruana Cayetano Heredia. Lima,; Aliaga Del Castillo, Rosalinda; Facultad de Estomatología, Universidad Peruana Cayetano Heredia. Lima,; Aliaga Del Castillo, Arón; Facultad de Estomatología, Universidad Peruana Cayetano Heredia. Lima,

    2014-01-01

    Las anomalías dentarias más frecuentes e importantes que afectan a los niños son la presencia de piezas supernumerarias, piezas retenidas y odontomas. Algunos dientes retenidos se pueden encontrar en  transposición. Reportamos el caso de una paciente de sexo femenino de 11 años de edad con presencia de diente supernumerario, canino en transposición y odontoma complejo situados en la hemiarcada derecha del maxilar superior. El motivo de consulta fue por la presencia de dientes anteriores sobre...

  11. Survey of large protein complexes D. vulgaris reveals great structural diversity

    Energy Technology Data Exchange (ETDEWEB)

    Han, B.-G.; Dong, M.; Liu, H.; Camp, L.; Geller, J.; Singer, M.; Hazen, T. C.; Choi, M.; Witkowska, H. E.; Ball, D. A.; Typke, D.; Downing, K. H.; Shatsky, M.; Brenner, S. E.; Chandonia, J.-M.; Biggin, M. D.; Glaeser, R. M.

    2009-08-15

    An unbiased survey has been made of the stable, most abundant multi-protein complexes in Desulfovibrio vulgaris Hildenborough (DvH) that are larger than Mr {approx} 400 k. The quaternary structures for 8 of the 16 complexes purified during this work were determined by single-particle reconstruction of negatively stained specimens, a success rate {approx}10 times greater than that of previous 'proteomic' screens. In addition, the subunit compositions and stoichiometries of the remaining complexes were determined by biochemical methods. Our data show that the structures of only two of these large complexes, out of the 13 in this set that have recognizable functions, can be modeled with confidence based on the structures of known homologs. These results indicate that there is significantly greater variability in the way that homologous prokaryotic macromolecular complexes are assembled than has generally been appreciated. As a consequence, we suggest that relying solely on previously determined quaternary structures for homologous proteins may not be sufficient to properly understand their role in another cell of interest.

  12. N,N-dimethylbiguanide complexes displaying low cytotoxicity as potential large spectrum antimicrobial agents.

    Science.gov (United States)

    Olar, Rodica; Badea, Mihaela; Marinescu, Dana; Chifiriuc, Mariana-Carmen; Bleotu, Coralia; Grecu, Maria Nicoleta; Iorgulescu, Emilia-Elena; Lazar, Veronica

    2010-07-01

    The new complexes M(DMBG)(2)(ClO(4))(2) (M:Mn, Ni, Cu and Zn; DMBG: N,N-dimethylbiguanide) have been synthesized and characterized by IR, EPR, (1)H NMR, (13)C NMR as well as electronic spectroscopy data. Complex [Ni(DMBG)(2)](ClO(4))(2).2DMF (DMF: N,N-dimethylformamide) crystallizes in the monoclinic P2(1)/c space group while [Cu(DMBG)(2)](ClO(4))(2) adopt monoclinic P21/c space group as X-ray single crystal data indicate. The redox behavior of complexes was investigated by cyclic voltammetry. The metal-free N,N-dimethylbiguanide and complexes exhibit specific anti-infective properties as demonstrated the low MIC values, a large antimicrobial spectrum and also inhibit the ability of Pseudomonas aeruginosa and Staphylococcus aureus strains to colonize the inert surfaces. The complexes exhibit also a low cytotoxicity levels on HeLa cells.

  13. Iterative methods for the solution of very large complex symmetric linear systems of equations in electrodynamics

    Energy Technology Data Exchange (ETDEWEB)

    Clemens, M.; Weiland, T. [Technische Hochschule Darmstadt (Germany)

    1996-12-31

    In the field of computational electrodynamics the discretization of Maxwell`s equations using the Finite Integration Theory (FIT) yields very large, sparse, complex symmetric linear systems of equations. For this class of complex non-Hermitian systems a number of conjugate gradient-type algorithms is considered. The complex version of the biconjugate gradient (BiCG) method by Jacobs can be extended to a whole class of methods for complex-symmetric algorithms SCBiCG(T, n), which only require one matrix vector multiplication per iteration step. In this class the well-known conjugate orthogonal conjugate gradient (COCG) method for complex-symmetric systems corresponds to the case n = 0. The case n = 1 yields the BiCGCR method which corresponds to the conjugate residual algorithm for the real-valued case. These methods in combination with a minimal residual smoothing process are applied separately to practical 3D electro-quasistatical and eddy-current problems in electrodynamics. The practical performance of the SCBiCG methods is compared with other methods such as QMR and TFQMR.

  14. [Complex ultrasonic diagnosis of large and gigantic non-parasitic cysts of liver].

    Science.gov (United States)

    Kuntsevich, G I; Gavrilin, A V; Vishnevskiĭ, V A; Zhurenkova, T V; Chebysheva, E N; Zhavoronkova, O I; Agafonov, V A

    2007-01-01

    The results of clinical and complex ultrasonic examination of 95 patients with large and gigantic liver non-parasitic cysts (LNC) are analyzed. The morphological examination was performed in all the cases. The mean diameter of large LNC was 105+/-7 mm, of gigantic cysts -- 149+/-33 mm (p<0,05), cyst volume was respectively 600+/-142 and 1721+/-954 ml (p<0,05). Analysis of clinical, ultrasonic and laboratory data allowed to describe three variants of large and gigantic, complicated and non-complicated cysts with 97,9% accuracy. The 3-D US reconstruction permitted to precise the anatomic structure and trace selection during transcutaneous US-assisted treatment.

  15. Electromagnetic, complex image model of a large area RF resonant antenna as inductive plasma source

    Science.gov (United States)

    Guittienne, Ph; Jacquier, R.; Howling, A. A.; Furno, I.

    2017-03-01

    A large area antenna generates a plasma by both inductive and capacitive coupling; it is an electromagnetically coupled plasma source. In this work, experiments on a large area planar RF antenna source are interpreted in terms of a multi-conductor transmission line coupled to the plasma. This electromagnetic treatment includes mutual inductive coupling using the complex image method, and capacitive matrix coupling between all elements of the resonant network and the plasma. The model reproduces antenna input impedance measurements, with and without plasma, on a 1.2× 1.2 m2 antenna used for large area plasma processing. Analytic expressions are given, and results are obtained by computation of the matrix solution. This method could be used to design planar inductive sources in general, by applying the termination impedances appropriate to each antenna type.

  16. Multi-agent based control of large-scale complex systems employing distributed dynamic inference engine

    Science.gov (United States)

    Zhang, Daili

    Increasing societal demand for automation has led to considerable efforts to control large-scale complex systems, especially in the area of autonomous intelligent control methods. The control system of a large-scale complex system needs to satisfy four system level requirements: robustness, flexibility, reusability, and scalability. Corresponding to the four system level requirements, there arise four major challenges. First, it is difficult to get accurate and complete information. Second, the system may be physically highly distributed. Third, the system evolves very quickly. Fourth, emergent global behaviors of the system can be caused by small disturbances at the component level. The Multi-Agent Based Control (MABC) method as an implementation of distributed intelligent control has been the focus of research since the 1970s, in an effort to solve the above-mentioned problems in controlling large-scale complex systems. However, to the author's best knowledge, all MABC systems for large-scale complex systems with significant uncertainties are problem-specific and thus difficult to extend to other domains or larger systems. This situation is partly due to the control architecture of multiple agents being determined by agent to agent coupling and interaction mechanisms. Therefore, the research objective of this dissertation is to develop a comprehensive, generalized framework for the control system design of general large-scale complex systems with significant uncertainties, with the focus on distributed control architecture design and distributed inference engine design. A Hybrid Multi-Agent Based Control (HyMABC) architecture is proposed by combining hierarchical control architecture and module control architecture with logical replication rings. First, it decomposes a complex system hierarchically; second, it combines the components in the same level as a module, and then designs common interfaces for all of the components in the same module; third, replications

  17. Odontoma compuesto: Diagnóstico radiográfico y tratamiento quirúrgico de un caso clínico Compound odontoma: Radiographic diagnosis and surgical management of a clinical case

    OpenAIRE

    J. Vázquez Diego; C. Gandini Pablo; E. Carbajal Eduardo

    2008-01-01

    Se presenta un caso clínico de odontoma compuesto asociado a un diente supernumerario y un canino retenido superior derecho. El paciente de 16 años de edad es de sexo masculino. Se realizan diversos estudios radiográficos para su diagnóstico, que consisten en técnica panorámica y técnicas intraorales. Posteriormente se realizó la intervención quirúrgica para extirpar la lesión y las estructuras dentarias asociadas a ella. El estudio histopatológico confirmó el diagnóstico presuntivo. Basado e...

  18. Large system change challenges: addressing complex critical issues in linked physical and social domains

    Science.gov (United States)

    Waddell, Steve; Cornell, Sarah; Hsueh, Joe; Ozer, Ceren; McLachlan, Milla; Birney, Anna

    2015-04-01

    Most action to address contemporary complex challenges, including the urgent issues of global sustainability, occurs piecemeal and without meaningful guidance from leading complex change knowledge and methods. The potential benefit of using such knowledge is greater efficacy of effort and investment. However, this knowledge and its associated tools and methods are under-utilized because understanding about them is low, fragmented between diverse knowledge traditions, and often requires shifts in mindsets and skills from expert-led to participant-based action. We have been engaged in diverse action-oriented research efforts in Large System Change for sustainability. For us, "large" systems can be characterized as large-scale systems - up to global - with many components, of many kinds (physical, biological, institutional, cultural/conceptual), operating at multiple levels, driven by multiple forces, and presenting major challenges for people involved. We see change of such systems as complex challenges, in contrast with simple or complicated problems, or chaotic situations. In other words, issues and sub-systems have unclear boundaries, interact with each other, and are often contradictory; dynamics are non-linear; issues are not "controllable", and "solutions" are "emergent" and often paradoxical. Since choices are opportunity-, power- and value-driven, these social, institutional and cultural factors need to be made explicit in any actionable theory of change. Our emerging network is sharing and building a knowledge base of experience, heuristics, and theories of change from multiple disciplines and practice domains. We will present our views on focal issues for the development of the field of large system change, which include processes of goal-setting and alignment; leverage of systemic transitions and transformation; and the role of choice in influencing critical change processes, when only some sub-systems or levels of the system behave in purposeful ways

  19. A large scale analysis of information-theoretic network complexity measures using chemical structures.

    Directory of Open Access Journals (Sweden)

    Matthias Dehmer

    Full Text Available This paper aims to investigate information-theoretic network complexity measures which have already been intensely used in mathematical- and medicinal chemistry including drug design. Numerous such measures have been developed so far but many of them lack a meaningful interpretation, e.g., we want to examine which kind of structural information they detect. Therefore, our main contribution is to shed light on the relatedness between some selected information measures for graphs by performing a large scale analysis using chemical networks. Starting from several sets containing real and synthetic chemical structures represented by graphs, we study the relatedness between a classical (partition-based complexity measure called the topological information content of a graph and some others inferred by a different paradigm leading to partition-independent measures. Moreover, we evaluate the uniqueness of network complexity measures numerically. Generally, a high uniqueness is an important and desirable property when designing novel topological descriptors having the potential to be applied to large chemical databases.

  20. New radio-frequency setup for studying large 2D complex plasma crystals

    Science.gov (United States)

    Nosenko, Vladimir; Meyer, John; Thomas, Hubertus

    2016-09-01

    There is a growing body of evidence that many properties of complex plasmas, such as thermal conductivity and diffusion coefficient may be system-size dependent. To test this assumption, experiments are needed where the size of a complex plasma can be varied in a wide range. So far, the existing experimental setups (based on various modifications of the GEC rf reference cell) allowed the maximum size of a good-quality 2D plasma crystal of about 6-7 cm. To obtain a much larger uniform 2D plasma crystal, a larger setup is necessary. In this presentation, we report on the new radio-frequency setup that has been built and is now operational in the Research Group on Complex Plasmas. It is based on a relatively large (90 cm in diameter) vacuum chamber where a radio-frequency discharge is used to levitate dust particles. The discharge is created between the lower rf electrode and the grounded chamber walls, the particles levitate in the plasma (pre)sheath above the electrode and are observed through the large top glass window and through the side windows. The first observations of plasma crystals in the new setup will be reported.

  1. Large eddy simulation on unstructured meshes using Lagrangian subgrid-scale model for complex turbulent flows

    Science.gov (United States)

    Tran, Steven; Sahni, Onkar; RPI Team

    2015-11-01

    Large eddy simulations (LES) provide high fidelity in which the large-scale turbulent structures are resolved while their interactions with the subgrid scales are modeled. In a Smagorinsky-based LES approach, the unresolved stresses are modeled using an eddy viscosity which in-turn involves a model parameter that is unknown a priori and varies in space and time for complex problems. Therefore, dynamic procedures are employed to determine this parameter where averaging is applied to make the procedure robust. When applicable, spatial averaging is applied across homogeneous directions. However, for complex flows the Lagrangian subgrid-scale model employing averaging over pathlines becomes attractive. In contrast to the dynamic Smagorinsky model, variational multiscale (VMS) models have also been developed for LES. In this study, we investigate dynamic mixed models for LES based on the combinations of the Lagrangian subgrid-scale model and the residual-based VMS (RBVMS) approach to study complex, inhomogeneous turbulent flows on unstructured meshes. Applications range from flow through a channel to flow over an airfoil at a moderate angle of attack. Experimental and DNS data are used to make comparisons.

  2. Discovering the influences of complex network effects on recovering large scale multiagent systems.

    Science.gov (United States)

    Xu, Yang; Liu, Pengfei; Li, Xiang; Ren, Wei

    2014-01-01

    Building efficient distributed coordination algorithms is critical for the large scale multiagent system design, and the communication network has been shown as a key factor to influence system performance even under the same coordination protocol. Although many distributed algorithm designs have been proved to be feasible to build their functions in the large scale multiagent systems as claimed, the performances may not be stable if the multiagent networks were organized with different complex network topologies. For example, if the network was recovered from the broken links or disfunction nodes, the network topology might have been shifted. Therefore, their influences on the overall multiagent system performance are unknown. In this paper, we have made an initial effort to find how a standard network recovery policy, MPLS algorithm, may change the network topology of the multiagent system in terms of network congestion. We have established that when the multiagent system is organized as different network topologies according to different complex network attributes, the network shifts in different ways. Those interesting discoveries are helpful to predict how complex network attributes influence on system performance and in turn are useful for new algorithm designs that make a good use of those attributes.

  3. Primordial Odontogenic Cyst with Induction Phenomenon (Zonal Fibroblastic Hypercellularity) and Dentinoid Material Versus Archegonous Cystic Odontoma: You Choose!

    Science.gov (United States)

    Argyris, Prokopios P; Wetzel, Stephanie L; Pambuccian, Stefan E; Gopalakrishnan, Rajaram; Koutlas, Ioannis G

    2016-06-01

    The most recent A.F.I.P. fascicle defines primordial odontogenic cyst (POC) as a distinct, nonkeratinized, odontogenic cyst of "undetermined origin" forming in the place of a developing normal or supernumerary tooth. However, the majority of examples reported in the literature under this term represent odontogenic keratocysts (keratocystic odontogenic tumors). In addition, there are rare reported cases of cystic odontomas. An 18-year-old Caucasian male presented with a unilocular mandibular radiolucent lesion in the place of a congenitally missing molar. Histologically, it featured nonkeratinizing, thin stratified squamous epithelial lining with areas of spongiosis and foci of vacuolization of individual basal cells without significant nuclear palisading. Focally, budding of the basal cell layer was identified. A zone of increased cellularity featuring induction-type fibroblasts was present subepithelially as well as dentinoid deposits with odontogenic epithelial nests. Immunohistochemically, the epithelial lining was negative for calretinin and the induction-like zone negative for S100 protein, smooth muscle actin, and CD34. The case was externally reviewed by five oral pathologists who provided various diagnostic interpretations including primordial cyst, odontogenic cyst not otherwise specified (NOS), cyst with ameloblastic changes, and unicystic ameloblastoma. At that time, a final diagnosis of odontogenic cyst NOS was rendered with a comment that it may represent a true example of POC or a cystic odontoma. The lesion has not recurred within a 13 year follow-up period after initial excision. An unusual cystic lesion is presented that may represent a true example of POC with dentinoid formation or an archegonous cystic odontoma.

  4. Final Report: Large-Scale Optimization for Bayesian Inference in Complex Systems

    Energy Technology Data Exchange (ETDEWEB)

    Ghattas, Omar [The University of Texas at Austin

    2013-10-15

    The SAGUARO (Scalable Algorithms for Groundwater Uncertainty Analysis and Robust Optimiza- tion) Project focuses on the development of scalable numerical algorithms for large-scale Bayesian inversion in complex systems that capitalize on advances in large-scale simulation-based optimiza- tion and inversion methods. Our research is directed in three complementary areas: efficient approximations of the Hessian operator, reductions in complexity of forward simulations via stochastic spectral approximations and model reduction, and employing large-scale optimization concepts to accelerate sampling. Our efforts are integrated in the context of a challenging testbed problem that considers subsurface reacting flow and transport. The MIT component of the SAGUARO Project addresses the intractability of conventional sampling methods for large-scale statistical inverse problems by devising reduced-order models that are faithful to the full-order model over a wide range of parameter values; sampling then employs the reduced model rather than the full model, resulting in very large computational savings. Results indicate little effect on the computed posterior distribution. On the other hand, in the Texas-Georgia Tech component of the project, we retain the full-order model, but exploit inverse problem structure (adjoint-based gradients and partial Hessian information of the parameter-to- observation map) to implicitly extract lower dimensional information on the posterior distribution; this greatly speeds up sampling methods, so that fewer sampling points are needed. We can think of these two approaches as "reduce then sample" and "sample then reduce." In fact, these two approaches are complementary, and can be used in conjunction with each other. Moreover, they both exploit deterministic inverse problem structure, in the form of adjoint-based gradient and Hessian information of the underlying parameter-to-observation map, to achieve their speedups.

  5. A Mode-Accelerated XXr (MAX) method for complex structures with large blends

    Science.gov (United States)

    Gan, Yiqian; Mayer, John L.; D'Souza, Kiran X.; Epureanu, Bogdan I.

    2017-09-01

    Various reduced order models have been proposed for characterizing cyclic symmetric structures with complex geometry and varying material properties that are subject to complex boundary or loading conditions. Small variations can be represented as small mass or stiffness mistuning. Techniques developed to handle such variations rely on the fact that the modes of the system can be accurately approximated using a linear combination of modes of the healthy/nominal system. Such approximations are valid in regions of high modal density, but they break down when variations are large or geometric changes are present. To address this challenge, a novel method is presented to predict the vibration response of cyclic symmetric structures with large geometric changes due to damage in the form of missing material (blends). The central idea of the new approach is an extension of the XXr method for cracked structures. The XXr method was developed for modeling small mistuning and large cracks. That method is extended in this work to handle large blends. In addition, a specialized component mode synthesis is combined with the extended XXr method to maintain accuracy. Also, unique to the proposed novel method is a technique to accelerate the convergence of the order reduction, and thus obtain very low order models. These low order models provide excellent computational speed and effectiveness while maintaining accuracy. Therefore, the method can be applied to highly refined, realistic models of industrial size. To demonstrate the proposed mode-accelerated XXr method, the effects of large blends on the response of a bladed disk are investigated.

  6. Surrogate-based Multi-Objective Optimization and Uncertainty Quantification Methods for Large, Complex Geophysical Models

    Science.gov (United States)

    Gong, Wei; Duan, Qingyun

    2016-04-01

    Parameterization scheme has significant influence to the simulation ability of large, complex dynamic geophysical models, such as distributed hydrological models, land surface models, weather and climate models, etc. with the growing knowledge of physical processes, the dynamic geophysical models include more and more processes and producing more output variables. Consequently the parameter optimization / uncertainty quantification algorithms should also be multi-objective compatible. Although such algorithms have long been available, they usually require a large number of model runs and are therefore computationally expensive for large, complex dynamic models. In this research, we have developed surrogate-based multi-objective optimization method (MO-ASMO) and Markov Chain Monte Carlo method (MC-ASMO) for uncertainty quantification for these expensive dynamic models. The aim of MO-ASMO and MC-ASMO is to reduce the total number of model runs with appropriate adaptive sampling strategy assisted by surrogate modeling. Moreover, we also developed a method that can steer the search process with the help of prior parameterization scheme derived from the physical processes involved, so that all of the objectives can be improved simultaneously. The proposed algorithms have been evaluated with test problems and a land surface model - the Common Land Model (CoLM). The results demonstrated their effectiveness and efficiency.

  7. Multiobjective adaptive surrogate modeling-based optimization for parameter estimation of large, complex geophysical models

    Science.gov (United States)

    Gong, Wei; Duan, Qingyun; Li, Jianduo; Wang, Chen; Di, Zhenhua; Ye, Aizhong; Miao, Chiyuan; Dai, Yongjiu

    2016-03-01

    Parameter specification is an important source of uncertainty in large, complex geophysical models. These models generally have multiple model outputs that require multiobjective optimization algorithms. Although such algorithms have long been available, they usually require a large number of model runs and are therefore computationally expensive for large, complex dynamic models. In this paper, a multiobjective adaptive surrogate modeling-based optimization (MO-ASMO) algorithm is introduced that aims to reduce computational cost while maintaining optimization effectiveness. Geophysical dynamic models usually have a prior parameterization scheme derived from the physical processes involved, and our goal is to improve all of the objectives by parameter calibration. In this study, we developed a method for directing the search processes toward the region that can improve all of the objectives simultaneously. We tested the MO-ASMO algorithm against NSGA-II and SUMO with 13 test functions and a land surface model - the Common Land Model (CoLM). The results demonstrated the effectiveness and efficiency of MO-ASMO.

  8. Frecuencia de intervenciones quirúrgicas de dientes supernumerarios, odontomas y dientes incluidos en odontopediatría

    OpenAIRE

    Aliaga Del Castillo, Rosalinda; Facultad de Estomatología. Universidad Peruana Cayetano Heredia. Lima,; Perea Paz, Miguel; Facultad de Estomatología. Universidad Peruana Cayetano Heredia. Lima,; Aliaga Del Castillo, Arón; Cirujano Dentista

    2014-01-01

    El propósito del presente estudio fue determinar la frecuencia y distribución de intervenciones quirúrgicas de dientes supernumerarios, odontomas y dientes incluidos en pacientes atendidos en el servicio de Odontopediatría de la clínica de postgrado de la Universidad Peruana Cayetano Heredia entre los años 2002-2009. Se evaluó: alteración dental, género, edad, localización, tipo de intervención quirúrgica y forma de presentación. La muestra estuvo constituida por 192 historias clínicas selecc...

  9. Some thoughts on the management of large, complex international space ventures

    Science.gov (United States)

    Lee, T. J.; Kutzer, Ants; Schneider, W. C.

    1992-01-01

    Management issues relevant to the development and deployment of large international space ventures are discussed with particular attention given to previous experience. Management approaches utilized in the past are labeled as either simple or complex, and signs of efficient management are examined. Simple approaches include those in which experiments and subsystems are developed for integration into spacecraft, and the Apollo-Soyuz Test Project is given as an example of a simple multinational approach. Complex approaches include those for ESA's Spacelab Project and the Space Station Freedom in which functional interfaces cross agency and political boundaries. It is concluded that individual elements of space programs should be managed by individual participating agencies, and overall configuration control is coordinated by level with a program director acting to manage overall objectives and project interfaces.

  10. Unfolding communities in large complex networks: Combining defensive and offensive label propagation for core extraction

    CERN Document Server

    Šubelj, Lovro; 10.1103/PhysRevE.83.036103

    2011-01-01

    Label propagation has proven to be a fast method for detecting communities in large complex networks. Recent developments have also improved the accuracy of the approach, however, a general algorithm is still an open issue. We present an advanced label propagation algorithm that combines two unique strategies of community formation, namely, defensive preservation and offensive expansion of communities. Two strategies are combined in a hierarchical manner, to recursively extract the core of the network, and to identify whisker communities. The algorithm was evaluated on two classes of benchmark networks with planted partition and on almost 25 real-world networks ranging from networks with tens of nodes to networks with several tens of millions of edges. It is shown to be comparable to the current state-of-the-art community detection algorithms and superior to all previous label propagation algorithms, with comparable time complexity. In particular, analysis on real-world networks has proven that the algorithm ...

  11. Axiomatic design in large systems complex products, buildings and manufacturing systems

    CERN Document Server

    Suh, Nam

    2016-01-01

    This book provides a synthesis of recent developments in Axiomatic Design theory and its application in large complex systems. Introductory chapters provide concise tutorial materials for graduate students and new practitioners, presenting the fundamentals of Axiomatic Design and relating its key concepts to those of model-based systems engineering. A mathematical exposition of design axioms is also provided. The main body of the book, which represents a concentrated treatment of several applications, is divided into three parts covering work on: complex products; buildings; and manufacturing systems. The book shows how design work in these areas can benefit from the scientific and systematic underpinning provided by Axiomatic Design, and in so doing effectively combines the state of the art in design research with practice. All contributions were written by an international group of leading proponents of Axiomatic Design. The book concludes with a call to action motivating further research into the engineeri...

  12. Geomorphological features and monitoring of a large and complex landslide near Avigliano urban area (South Italy

    Directory of Open Access Journals (Sweden)

    F. Sdao

    2005-01-01

    Full Text Available This paper reports the results of geological and geomorphological surveys and the first results of a still in progress GPS monitoring campaign, taken on a large and ancient landslide located near Avigliano town (Basilicata region, South Italy. The landslide occurs on structurally complex clayey-marly terrains and it is classifiable as a multiple and complex roto-translational-earthflow landslide. In the last years this landslide has been affected by frequent reactivations that have been the cause of grave damages to the urban structures in the area. During January 2004, in order to monitor the present kinematics of the landslide body, a GPS network was installed. Until today several GPS surveys have been carried out. The results of GPS data analysis show centimetres level motions going on the landslide. The final goal of the research will be to define a hazard evaluation and an evolution model of the landslide, using the integrated information coming from GPS and geomorphological surveys.

  13. Conceptual Framework and Levels of Abstraction for a Complex Large-Scale System

    Energy Technology Data Exchange (ETDEWEB)

    Simpson, Mary J.

    2005-03-23

    A conceptual framework and levels of abstraction are created to apply across all potential threats. Bioterrorism is used as a complex example to describe the general framework. Bioterrorism is unlimited with respect to the use of a specific agent, mode of dissemination, and potential target. Because the threat is open-ended, there is a strong need for a common, systemic understanding of attack scenarios related to bioterrorism. In recognition of this large-scale complex problem, systems are being created to define, design and use the proper level of abstraction and conceptual framework in bioterrorism. The wide variety of biological agents and delivery mechanisms provide an opportunity for dynamic scale changes by the linking or interlinking of existing threat components. Concurrent impacts must be separated and evaluated in terms of a given environment and/or ‘abstraction framework.’

  14. Modeling and Simulation of Complex Network Attributes on Coordinating Large Multiagent System

    Science.gov (United States)

    Li, Xiang; Liu, Ming

    2014-01-01

    With the expansion of distributed multiagent systems, traditional coordination strategy becomes a severe bottleneck when the system scales up to hundreds of agents. The key challenge is that in typical large multiagent systems, sparsely distributed agents can only communicate directly with very few others and the network is typically modeled as an adaptive complex network. In this paper, we present simulation testbed CoordSim built to model the coordination of network centric multiagent systems. Based on the token-based strategy, the coordination can be built as a communication decision problem that agents make decisions to target communications and pass them over to the capable agents who will potentially benefit the team most. We have theoretically analyzed that the characters of complex network make a significant difference with both random and intelligent coordination strategies, which may contribute to future multiagent algorithm design. PMID:24955399

  15. A comparative analysis of Indoor WiFi Positioning at a large building complex

    DEFF Research Database (Denmark)

    Mathisen, Andreas; Krogh, Søren; Stisen, Allan

    2016-01-01

    Indoor Positioning based on WiFi has received extensive focus from research communities, owing its promises of ubiquitous positioning indoors for a variety of applications. The majority of the existing research on WiFi positioning centers around the improvement of positioning accuracy. However......, as only few experimental evaluations have been reported in such environments. This paper presents a comparative evaluation of several indoor positioning techniques set at a large university hospital spanning 160, 000m2—an environment where several location and context-aware logistic applications...... with implementing and using indoor positioning solutions in a highly diverse environment, in which building types and materials, as well as building use differ across the complex. Correspondingly, the evaluation data we use is gathered at different complex parts, days, and daytimes, and both at static locations...

  16. On simplicity and complexity in the brave new world of large-scale neuroscience.

    Science.gov (United States)

    Gao, Peiran; Ganguli, Surya

    2015-06-01

    Technological advances have dramatically expanded our ability to probe multi-neuronal dynamics and connectivity in the brain. However, our ability to extract a simple conceptual understanding from complex data is increasingly hampered by the lack of theoretically principled data analytic procedures, as well as theoretical frameworks for how circuit connectivity and dynamics can conspire to generate emergent behavioral and cognitive functions. We review and outline potential avenues for progress, including new theories of high dimensional data analysis, the need to analyze complex artificial networks, and methods for analyzing entire spaces of circuit models, rather than one model at a time. Such interplay between experiments, data analysis and theory will be indispensable in catalyzing conceptual advances in the age of large-scale neuroscience.

  17. Engineering a large application software project: the controls of the CERN PS accelerator complex

    Energy Technology Data Exchange (ETDEWEB)

    Benincasa, G.P.; Daneels, A.; Heymans, P.; Serre, Ch.

    1985-10-01

    The CERN PS accelerator complex has been progressively converted to full computer controls without interrupting its full-time operation (more than 6000 hours per year with on average not more than 1% of the total down-time due to controls). The application software amounts to 120 man-years and 450'000 instructions: it compares with other large software projects, also outside the accelerator world: e.g. Skylab's ground support software. This paper outlines the application software structure which takes into account technical requirements and constraints (resulting from the complexity of the process and its operation) and economical and managerial ones. It presents the engineering and management techniques used to promote implementation, testing and commissioning within budget, manpower and time constraints and concludes with experience gained.

  18. Modified components separation technique: experience treating large, complex ventral hernias at a University Hospital.

    Science.gov (United States)

    Torregrosa-Gallud, A; Sancho Muriel, J; Bueno-Lledó, J; García Pastor, P; Iserte-Hernandez, J; Bonafé-Diana, S; Carreño-Sáenz, O; Carbonell-Tatay, F

    2017-08-01

    An increasing number of patients have large or complex abdominal wall defects. Component separation technique (CST) is a very effective method for reconstructing complex midline abdominal wall defects in a manner that restores innervated muscle function without excessive tension. Our goal is to show our results by a modified CST for treating large ventral hernias. A total of 351 patients with complex ventral hernias have been treated over a 10-year period. Pre- and postoperative CT scans were performed in all patients. All ventral hernias were W3, according to the EHS classification 1. We analyzed demographic variables, co-morbidities, hernia characteristics, operative, and postoperative variables. One hundred and seventy patients (48.4%) were men; the average age of the study population was 51.6 ± 23.2 years with an average BMI of 32.3 ± 1.3. The hernia was located in the midline in 321 cases (91.5%) versus the flank in 30 (8.5%). In 45 patients, preoperative botulinum toxin (BT) and progressive pneumoperitoneum (PPP) were needed due to giant hernia defects when the VIH/VAC ratio was >20%. Postoperative complications related to the surgical site were seroma (35.1%), hematoma (9.1%), infection (7.2%), and wound necrosis (8.8%). Complications related to the repair were evisceration in 3 patients (1.1%), small bowel fistula in 4 patients (1.5%), 11 cases of mesh infection (2.9%), and abdominal compartment syndrome (ACS) in 2 patients. There were 29 hernia recurrences (8.2%) with a mean follow-up of 31.6 ± 8.1 months. The modified CST is an effective strategy for managing complex ventral hernias that enables primary fascial closure with low rates of morbidity and hernia recurrence.

  19. Descriptive Study of an Outbreak of Avian Urolithiasis in a Large Commercial Egg Complex in Algeria

    Directory of Open Access Journals (Sweden)

    Hicham SID

    2011-03-01

    Full Text Available Avian urolithiasis is one of the major causes of mortality in poultry. However, in Algeria this condition has never been described. An outbreak of avian urolithiasis was observed on a large commercial egg complex in the department of Chlef (West of Algeria. The clinical features of this condition are to be described. Mortality associated to urolithiasis started at the onset of egg production, estimated to 0.7 % per week. Urolithiasis induced an egg drop estimated to 12%. Dead and live layers were both necropsied and examined for kidney lesions. Most of the birds examined presented enlarged ureters, renal atrophy and visceral gout deposition.

  20. A Project Management Approach to Using Simulation for Cost Estimation on Large, Complex Software Development Projects

    Science.gov (United States)

    Mizell, Carolyn; Malone, Linda

    2007-01-01

    It is very difficult for project managers to develop accurate cost and schedule estimates for large, complex software development projects. None of the approaches or tools available today can estimate the true cost of software with any high degree of accuracy early in a project. This paper provides an approach that utilizes a software development process simulation model that considers and conveys the level of uncertainty that exists when developing an initial estimate. A NASA project will be analyzed using simulation and data from the Software Engineering Laboratory to show the benefits of such an approach.

  1. Control protocol: large scale implementation at the CERN PS complex - a first assessment

    Energy Technology Data Exchange (ETDEWEB)

    Abie, H. (CERN, 1211, Geneva 23 (Switzerland)); Benincasa, G. (CERN, 1211, Geneva 23 (Switzerland)); Coudert, G. (CERN, 1211, Geneva 23 (Switzerland)); Davydenko, Y. (CERN, 1211, Geneva 23 (Switzerland)); Dehavay, C. (CERN, 1211, Geneva 23 (Switzerland)); Gavaggio, R. (CERN, 1211, Geneva 23 (Switzerland)); Gelato, G. (CERN, 1211, Geneva 23 (Switzerland)); Heinze, W. (CERN, 1211, Geneva 23 (Switzerland)); Legras, M. (CERN, 1211, Geneva 23 (Switzerland)); Lustig, H. (CERN, 1211, Geneva 23 (Switzerland)); Merard, L. (CERN, 1211, Geneva 23 (Switzerland)); Pearson, T. (CERN, 1211, Geneva 23 (Switzerland)); Strubin, P. (CERN, 1211, Geneva 23 (Switzerland)); Tedesco, J. (CERN, 1211, Geneva 23 (Switzerland))

    1994-12-15

    The Control Protocol is a model-based, uniform access procedure from a control system to accelerator equipment. It was proposed at CERN about 5 years ago and prototypes were developed in the following years. More recently, this procedure has been finalized and implemented at a large scale in the PS Complex. More than 300 pieces of equipment are now using this protocol in normal operation and another 300 are under implementation. These include power converters, vacuum systems, beam instrumentation devices, RF equipment, etc. This paper describes how the single general procedure is applied to the different kinds of equipment. The advantages obtained are also discussed. ((orig.))

  2. Control protocol: large scale implementation at the CERN PS complex — a first assessment

    Science.gov (United States)

    Abie, H.; Benincasa, G.; Coudert, G.; Davydenko, Y.; Dehavay, C.; Gavaggio, R.; Gelato, G.; Heinze, W.; Legras, M.; Lustig, H.; Merard, L.; Pearson, T.; Strubin, P.; Tedesco, J.

    1994-12-01

    The Control Protocol is a model-based, uniform access procedure from a control system to accelerator equipment. It was proposed at CERN about 5 years ago and prototypes were developed in the following years. More recently, this procedure has been finalized and implemented at a large scale in the PS Complex. More than 300 pieces of equipment are now using this protocol in normal operation and another 300 are under implementation. These include power converters, vacuum systems, beam instrumentation devices, RF equipment, etc. This paper describes how the single general procedure is applied to the different kinds of equipment. The advantages obtained are also discussed.

  3. Large-scale lattice Boltzmann simulations of complex fluids: advances through the advent of computational Grids.

    Science.gov (United States)

    Harting, Jens; Chin, Jonathan; Venturoli, Maddalena; Coveney, Peter V

    2005-08-15

    During the last 2.5 years, the RealityGrid project has allowed us to be one of the few scientific groups involved in the development of computational Grids. Since smoothly working production Grids are not yet available, we have been able to substantially influence the direction of software and Grid deployment within the project. In this paper, we review our results from large-scale three-dimensional lattice Boltzmann simulations performed over the last 2.5 years. We describe how the proactive use of computational steering, and advanced job migration and visualization techniques enabled us to do our scientific work more efficiently. The projects reported on in this paper are studies of complex fluid flows under shear or in porous media, as well as large-scale parameter searches, and studies of the self-organization of liquid cubic mesophases.

  4. Management of large complex multi-stakeholders projects: a bibliometric approach

    Directory of Open Access Journals (Sweden)

    Aline Sacchi Homrich

    2017-06-01

    Full Text Available The growing global importance of large infrastructure projects has piqued the interest of many researchers in a variety of issues related to the management of large, multi-stakeholder projects, characterized by their high complexity and intense interaction among numerous stake-holders with distinct levels of responsibility. The objective of this study is to provide an overview of the academic literature focused on the management of these kinds of projects, describing the main themes considered, the lines of research identified and prominent trends. Bibliometric analysis techniques were used as well as network and content analysis. Research for information was performed in the scientific database, ISI Web of Knowledge and Scopus. The initial sample analysis consisted of 144 papers published between 1984 and 2014 and expanded to the references cited in these papers. The models identified in the literature converge with the following key-processes: project delivery systems; risk-management models; project cost management; public-private partnership.

  5. Clinical and radiological profile of ameloblastic fibro-odontoma: an update on an uncommon odontogenic tumor based on a critical analysis of 114 cases.

    Science.gov (United States)

    Buchner, Amos; Kaffe, Israel; Vered, Marilena

    2013-03-01

    Ameloblastic fibro-odontoma is an uncommon benign tumor of the jaws that belongs to the group of mixed odontogenic tumors. The descriptions of its clinical and radiological features in the literature are not always accurate and sometimes even contradictory. The aim of the present study was to critically evaluate their clinical and radiological features as reported in the English-language literature. A total of 114 well-documented cases of ameloblastic fibro-odontomas (103 from publications and 11 of our own new cases) were analyzed. The patients' age ranged from 8 months to 26 years (mean 9.6). There were 74 (65 %) males, with a male-to-female ratio of 1.85:1 (P = 0.001). The mandible was involved in 74 (65 %) cases, and the mandible-to-maxilla ratio was 1.85:1 (P odontomas are significantly more common in males and in the mandible, and that multilocular lesions are uncommon. It also revealed that, based on their clinical and radiological features, some of them are probably true neoplasms while others appear to be developing odontomas (hamartomas).

  6. Pump schedules optimisation with pressure aspects in complex large-scale water distribution systems

    Directory of Open Access Journals (Sweden)

    P. Skworcow

    2014-06-01

    Full Text Available This paper considers optimisation of pump and valve schedules in complex large-scale water distribution networks (WDN, taking into account pressure aspects such as minimum service pressure and pressure-dependent leakage. An optimisation model is automatically generated in the GAMS language from a hydraulic model in the EPANET format and from additional files describing operational constraints, electricity tariffs and pump station configurations. The paper describes in details how each hydraulic component is modelled. To reduce the size of the optimisation problem the full hydraulic model is simplified using module reduction algorithm, while retaining the nonlinear characteristics of the model. Subsequently, a nonlinear programming solver CONOPT is used to solve the optimisation model, which is in the form of Nonlinear Programming with Discontinuous Derivatives (DNLP. The results produced by CONOPT are processed further by heuristic algorithms to generate integer solution. The proposed approached was tested on a large-scale WDN model provided in the EPANET format. The considered WDN included complex structures and interactions between pump stations. Solving of several scenarios considering different horizons, time steps, operational constraints, demand levels and topological changes demonstrated ability of the approach to automatically generate and solve optimisation problems for a variety of requirements.

  7. Pump schedules optimisation with pressure aspects in complex large-scale water distribution systems

    Directory of Open Access Journals (Sweden)

    P. Skworcow

    2014-02-01

    Full Text Available This paper considers optimisation of pump and valve schedules in complex large-scale water distribution networks (WDN, taking into account pressure aspects such as minimum service pressure and pressure-dependent leakage. An optimisation model is automatically generated in GAMS language from a hydraulic model in EPANET format and from additional files describing operational constraints, electricity tariffs and pump station configurations. The paper describes in details how each hydraulic component is modelled. To reduce the size of the optimisation problem the full hydraulic model is simplified using module reduction algorithm, while retaining the nonlinear characteristics of the model. Subsequently, a nonlinear programming solver CONOPT is used to solve the optimisation model, which is in the form of Nonlinear Programming with Discontinuous Derivatives (DNLP. The results produced by CONOPT are processed further by heuristic algorithms to generate integer solution. The proposed approached was tested on a large-scale WDN model provided in EPANET format. The considered WDN included complex structures and interactions between pump stations. Solving of several scenarios considering different horizons, time steps, operational constraints, demand levels and topological changes demonstrated ability of the approach to automatically generate and solve optimisation problems for variety of requirements.

  8. Topological string on toric CY3s in large complex structure limit

    Energy Technology Data Exchange (ETDEWEB)

    Drissi, Lalla Btissam [Lab/UFR - Physique des Hautes Energies, Faculte des Sciences, Rabat (Morocco); GNPHE, Groupement National de Physique des Hautes Energies, Siege focal: FS, Rabat (Morocco)], E-mail: drissilb@gmail.com; Jehjouh, Houda [Lab/UFR - Physique des Hautes Energies, Faculte des Sciences, Rabat (Morocco); GNPHE, Groupement National de Physique des Hautes Energies, Siege focal: FS, Rabat (Morocco)], E-mail: jehjouh@gmail.com; Saidi, El Hassan [Lab/UFR - Physique des Hautes Energies, Faculte des Sciences, Rabat (Morocco); GNPHE, Groupement National de Physique des Hautes Energies, Siege focal: FS, Rabat (Morocco)], E-mail: h-saidi@fsr.ac.ma

    2009-06-01

    We develop a non-planar topological vertex formalism and we use it to study the A-model partition function Z{sub top} of topological string on the class of toric Calabi-Yau threefolds (CY3) in large complex structure limit. To that purpose, we first consider the T{sup 2}xR special Lagrangian fibration of generic CY3-folds and we give the realization of the class of large {mu} toric CY3-folds in terms of supersymmetric gauged linear sigma model with non-zero gauge invariant superpotentials W({phi}). Then, we focus on a one complex parameter supersymmetric U(1) gauged model involving six chiral superfields {l_brace}{phi}{sub i}{r_brace} with W={mu}({pi}{sub i=0}{sup 5}{phi}{sub i}) and we use it to compute the function Z{sub top} for the case of the local elliptic curve in the limit {mu}{yields}{infinity}.

  9. Geometrical principium of fewer-axis grinding for large complex optical mirrors

    Institute of Scientific and Technical Information of China (English)

    JIANG; ZhenHua; YIN; YueHong

    2013-01-01

    Ultraprecision grinding is an important approach to efficiently fabricate large complex optical mirrors, and five-axis grinding method is commonly used for ultraprecision grinding. However, this method can hardly meet the high stiffness requirement for grinding large mirror, especially with a diameter over 2 m. Meanwhile, the use of fewer-axis grinding solves this problem, as it reduces the number of the grinder’s axes to improve the rigidity of the system and minimize deformation for hard and brittle materials. But its characteristic of unfixed grinding point which changes with workpiece surface curvature increases geometric complexity and requires a higher geometric shape accuracy of grinding wheel. This paper parameterizes grinding wheel’s geometric shape, reveals the relationship between fewer-axis and five-axis grinding methods from the point of view of the differential geometry, and establishes virtual-axis equivalence principium of feweraxis grinding. A quantitative method to determine grinding wheel’s geometric parameters and its shaft inclination angle is proposed based on the requirements of geometric properties of optical mirror, grinder features and grinding process. Moreover, according to the properties of Gauss curvature of curved surface, the wear law of the toric grinding wheel is found and the surface geometric error distribution due to wear is achieved for fewer-axis grinding. The correctness of the principium and method above are verified through simulations.

  10. An accurate and efficient computation method of the hydration free energy of a large, complex molecule.

    Science.gov (United States)

    Yoshidome, Takashi; Ekimoto, Toru; Matubayasi, Nobuyuki; Harano, Yuichi; Kinoshita, Masahiro; Ikeguchi, Mitsunori

    2015-05-07

    The hydration free energy (HFE) is a crucially important physical quantity to discuss various chemical processes in aqueous solutions. Although an explicit-solvent computation with molecular dynamics (MD) simulations is a preferable treatment of the HFE, huge computational load has been inevitable for large, complex solutes like proteins. In the present paper, we propose an efficient computation method for the HFE. In our method, the HFE is computed as a sum of 〈UUV〉/2 (〈UUV〉 is the ensemble average of the sum of pair interaction energy between solute and water molecule) and the water reorganization term mainly reflecting the excluded volume effect. Since 〈UUV〉 can readily be computed through a MD of the system composed of solute and water, an efficient computation of the latter term leads to a reduction of computational load. We demonstrate that the water reorganization term can quantitatively be calculated using the morphometric approach (MA) which expresses the term as the linear combinations of the four geometric measures of a solute and the corresponding coefficients determined with the energy representation (ER) method. Since the MA enables us to finish the computation of the solvent reorganization term in less than 0.1 s once the coefficients are determined, the use of the MA enables us to provide an efficient computation of the HFE even for large, complex solutes. Through the applications, we find that our method has almost the same quantitative performance as the ER method with substantial reduction of the computational load.

  11. LARGE EDDY SIMULATION OF COMPLEX TURBULENT FLOWS: PHYSICAL ASPECTS AND RESEARCH TRENDS

    Institute of Scientific and Technical Information of China (English)

    李家春

    2001-01-01

    In the current paper, we have primarily addressed one powerful simulation tool developed during the last decades Large Eddy Simulation (LES), which is most suitable for unsteady three-dimensional complex turbulent flows in industry and natural environment. The main point in LES is that the large-scale motion is resolved while the small-scale motion is modeled or, in geophysical terminology, pa-rameterized. With a view to devising a subgrid-scale(SGS) model of high quality, we have highlighted analyzing physical aspects in scale interaction and energy transfer such as dissipation, backscatter, local and non-local interaction, anisotropy and resolution requirement. They are the factors responsible for where the advantages and disadvantages in existing SGS models come from. A case study on LES of turbulence in vegetative canopy is presented to illustrate that LES model is more based on physical arguments. Then, varieties of challenging complex turbulent flows in both industry and geophysical fields in the near future are presented. In conclusion, we may say with confidence that new century shall see the flourish in the research of turbulence with the aid of LES combined with other approaches.

  12. Megacities and Large Urban Complexes - WMO Role in Addressing Challenges and Opportunities

    Science.gov (United States)

    Terblanche, Deon; Jalkanen, Liisa

    2013-04-01

    Megacities and Large Urban Complexes - WMO Role in Addressing Challenges and Opportunities Deon E. Terblanche and Liisa Jalkanen dterblanche@wmo.int ljalkanen@wmo.int World Meteorological Organization, Geneva, Switzerland The 21st Century could amongst others, become known as the century in which our species has evolved from Homo sapiens to Homo urbanus. By now the urban population has surpassed the rural population and the rate of urbanization will continue at such a pace that by 2050 urban dwellers could outnumber their rural counterpart by more than two to one. Most of this growth in urban population will occur in developing countries and along coastal areas. Urbanization is to a large extent the outcome of humans seeking a better life through improved opportunities presented by high-density communities. Megacities and large urban complexes provide more job opportunities and social structures, better transport and communication links and a relative abundance of physical goods and services when compared to most rural areas. Unfortunately these urban complexes also present numerous social and environmental challenges. Urban areas differ from their surroundings by morphology, population density, and with high concentration of industrial activities, energy consumption and transport. They also pose unique challenges to atmospheric modelling and monitoring and create a multi-disciplinary spectrum of potential threats, including air pollution, which need to be addressed in an integrated way. These areas are also vulnerable to the changing climate and its implications to sea-level and extreme events, air quality and related health impacts. Many urban activities are significantly impacted by weather events that would not be considered to be of high impact in less densely populated areas. For instance, moderate precipitation events can cause flooding and landslides as modified urban catchments generally have higher run-off to rainfall ratios than their more pristine rural

  13. Organizational Influences on Interdisciplinary Interactions during Research and Design of Large-Scale Complex Engineered Systems

    Science.gov (United States)

    McGowan, Anna-Maria R.; Seifert, Colleen M.; Papalambros, Panos Y.

    2012-01-01

    The design of large-scale complex engineered systems (LaCES) such as an aircraft is inherently interdisciplinary. Multiple engineering disciplines, drawing from a team of hundreds to thousands of engineers and scientists, are woven together throughout the research, development, and systems engineering processes to realize one system. Though research and development (R&D) is typically focused in single disciplines, the interdependencies involved in LaCES require interdisciplinary R&D efforts. This study investigates the interdisciplinary interactions that take place during the R&D and early conceptual design phases in the design of LaCES. Our theoretical framework is informed by both engineering practices and social science research on complex organizations. This paper provides preliminary perspective on some of the organizational influences on interdisciplinary interactions based on organization theory (specifically sensemaking), data from a survey of LaCES experts, and the authors experience in the research and design. The analysis reveals couplings between the engineered system and the organization that creates it. Survey respondents noted the importance of interdisciplinary interactions and their significant benefit to the engineered system, such as innovation and problem mitigation. Substantial obstacles to interdisciplinarity are uncovered beyond engineering that include communication and organizational challenges. Addressing these challenges may ultimately foster greater efficiencies in the design and development of LaCES and improved system performance by assisting with the collective integration of interdependent knowledge bases early in the R&D effort. This research suggests that organizational and human dynamics heavily influence and even constrain the engineering effort for large-scale complex systems.

  14. The dynamical complexity of work-hardening: a large-scale molecular dynamics simulation

    Institute of Scientific and Technical Information of China (English)

    Markus J. Buehler; Alexander Hartmaier; Mark A. Duchaineau; Farid F. Abraham; Huajian Gao

    2005-01-01

    We analyze a large-scale molecular dynamics simulation of work hardening in a model system of a ductile solid.With tensile loading, we observe emission of thousands of dislocations from two sharp cracks. The dislocations interact in a complex way, revealing three fundamental mechanisms of work-hardening in this ductile material. These are (1) dislocation cutting processes, jog formation and generation of trails of point defects; (2) activation of secondary slip systems by Frank-Read and cross-slip mechanisms; and (3) formation of sessile dislocations such as Lomer-Cottrell locks.We report the discovery of a new class of point defects referred to as trail of partial point defects, which could play an important role in situations when partial dislocations dominate plasticity. Another important result of the present work is the rediscovery of the Fleischer-mechanism of cross-slip of partial dislocations that was theoretically proposed more than 50 years ago, and is now, for the first time, confirmed by atomistic simulation. On the typical time scale of molecular dynamics simulations, the dislocations self-organize into a complex sessile defect topology. Our analysis illustrates numerous mechanisms formerly only conjectured in textbooks and observed indirectly in experiments. It is the first time that such a rich set of fundamental phenomena have been revealed in a single computer simulation, and its dynamical evolution has been studied. The present study exemplifies the simulation and analysis of the complex nonlinear dynamics of a many-particle system during failure using ultra-large scale computing.

  15. Odontoma localizado dentro del conducto dentario inferior: diagnóstico radiográfico y tratamiento quirúrgico de un caso clínico Odontoma located within the inferior alveolar nerve: radiographic diagnosis and surgical management of a clinical case

    Directory of Open Access Journals (Sweden)

    J. Vázquez Diego

    2009-08-01

    Full Text Available Se presenta un caso clínico de odontoma localizado dentro del conducto dentario inferior. El paciente de 54 años de edad es de sexo femenino. Se utiliza la técnica radiográfica panorámica para poder localizar y diagnosticar la afección. Posteriormente se realizó la intervención quirúrgica para extirpar la lesión y se realizó un seguimiento a corto y largo plazo para evaluar la recuperación de la sensibilidad de la zona afectada. El estudio histopatológico confirmó el diagnóstico de odontoma. Basado en lo expuesto se analiza al odontoma según ubicación, sexo y edad habiendo realizado una revisión de la literatura representada en tablas y gráficos.A clinical case of odontoma, located within the inferior dental nerve in a 54-year-old female patient, is reported. The lesion was situated and diagnosed by means of a conventional panoramic radiography technique. Then, a surgical approach was carried out to remove the pathological entity, and a short- and long-term follow-up control was done to evaluate sensitive recovery of the involved area. Later on, a histo-pathological study confirmed our previous diagnosis of odontoma. Based on our findings, odontoma is analyzed according to its location, sex and age of patients, as well as radiographic appearance. This analysis is presented through tables and graphics, after reviewing the scientific literature on this subject published over the last decade.

  16. Enucleación de odontoma compuesto maxilar con regeneración ósea guiada

    Directory of Open Access Journals (Sweden)

    A. Martínez Martínez

    2013-12-01

    Full Text Available Los odontomas son tumores odontogénicos benignos de los maxilares, asociados con frecuencia a retención dentaria, suelen tener un comportamiento indolente, diagnosticándose en radiografías de rutina. El defecto óseo como consecuencia de la osteotomía durante la enucleación del tumor, es una de las principales secuelas que el clínico debe tener presente por la afección no sólo al tejido duro sino también al tejido suave circundante, por esta razón, se han sugerido diferentes materiales para regenerar el tejido óseo perdido. Se reporta caso de paciente masculino de 33 años de edad que asistió a consulta manifestando insatisfacción estética por persistencia de órgano temporal 51 causado por la presencia de un odontoma compuesto, cuyo diagnóstico se corroboró clínica e histológicamente. El defecto óseo residual a la enucleación de dicho tumor se rellenó con hidroxiapatita no reabsorbible, para su posterior restauración definitiva. En el control postoperatorio, se observó resultados estéticos y funcionales satisfactorios.

  17. A new osteopetrosis mutant mouse strain (ntl) with odontoma-like proliferations and lack of tooth roots.

    Science.gov (United States)

    Lu, Xincheng; Rios, Hector F; Jiang, Baichun; Xing, Lianping; Kadlcek, Renata; Greenfield, Edward M; Luo, Guangbin; Feng, Jian Q

    2009-12-01

    A new spontaneous mouse mutant (ntl) with autosomal-recessive osteopetrosis was characterized. These mice formed tartrate-resistant acid phosphate (TRAP)-positive osteoclasts but their osteoclasts had no ruffled border and did not resorb bone. These mice displayed no tooth eruption or tooth root formation. Adult mutant mice developed odontoma-like proliferations near the proximal ends of the incisors. Intraperitoneal injection of progenitor cells from the liver of 16.5 days postcoitum wild-type embryos into newborn mutants rescued the osteopetrosis phenotype, indicating that the defects were intrinsic to the osteoclasts. Our findings not only provide further support for a critical role of osteoclasts in tooth eruption and tooth root development, but also suggest that the perturbation of the homeostasis of the odontogenic precursors of the incisors is primarily responsible for the development of the odontoma-like proliferations in this osteopetrosis mutant. Genetic mapping has narrowed down the location of the mutant allele to a genetic interval of 3.2 cM on mouse chromosome 17.

  18. Simultaneous occurrence of compound odontoma and arrested root formation as developmental disturbances after maxillofacial trauma: a case report.

    Science.gov (United States)

    Güngörmüş, Metin; Yolcu, Umit; Aras, Mutan-Hamdi; Halicioğlu, Koray

    2010-03-01

    Traumatic injury to a primary tooth and/or a bone fracture has the potential to damage the underlying permanent tooth germ which may disturb its development. The extent of the malformation depends on the developmental stage of the permanent tooth and the intensity of the trauma. The presence of infection may be a predictive factor for these abnormalities. Open surgical procedures can also potentially cause impaction and developmental disturbances. Several developmental alterations such as discolouration, hypoplasia, crown dilaceration, root angulation or dilaceration, sequestration of permanent tooth buds and disturbance in eruption have been reported in permanent teeth after trauma. However, odontoma-like malformations and partial or complete arrest of root formation are rare complications developed after trauma. This article presents a rare case with simultaneous occurrence of an odontoma-like malformation and complete and partial arrested root formations as the results of maxillofacial trauma. Almost all pediatric fractures must be managed with closed reduction as much as possible. However, if it is necessary to perform an open reduction, careful attention must be paid during placement of the osteosynthetic plates and screws; and tooth bud development must be followed periodically.

  19. A Peripheral Ameloblastic Fibro-Odontoma in a 3-Year-Old Girl: Case Report, Immunohistochemical Analysis, and Literature Review

    Directory of Open Access Journals (Sweden)

    Yi-Chun Lin

    2014-01-01

    Full Text Available Ameloblastic fibro-odontoma (AFO predominantly occurs in the jaw bones of children and young adults. Extraosseous AFO is extremely rare. We describe a peripheral ameloblastic fibro-odontoma in the maxillary gingiva of a 3-year-old girl. The clinical appearance resembled fiery red reactive gingival lesions. The histopathological examination of the excised lesion showed small islands and cords of odontogenic epithelium with cellular myxoid stroma in the subepithelial tissue. The mass contained calcified material and an enamel-like deposit. Many small blood vessels appeared in the connective tissue surrounding the odontogenic epithelium. The immunohistochemical assays showed strong reactivity for amelogenin, β-catenin, CD44, and CD31 in the tissue sections. There was no recurrence after the 1-year follow-up. Because this lesion clinically resembles other nonneoplastic lesions and is very rare in gingiva, establishing a correct diagnosis is achieved only based on specific histological characteristics. Conservative excision of the tumor is the treatment of choice.

  20. Odontoma compuesto: aplicación a la regeneración ósea guiada con membrana absorbible de colágeno en un defecto de dos corticales

    OpenAIRE

    Patiño Illa, C.; Buenechea Imaz, Ramón; Berástegui, Esther; Gay Escoda, Cosme

    1997-01-01

    Describimos el caso de una paciente que consultó por una pulpitis aguda en el 11 asociada a un odontoma compuesto periapical. La extracción quirúrgica del odontoma provocó un defecto en túnel que fue tratado según el principio de la regeneración ósea guiada con una membrana de colágeno reabsorbible.

  1. A novel multiblock immersed boundary method for large eddy simulation of complex arterial hemodynamics.

    Science.gov (United States)

    Anupindi, Kameswararao; Delorme, Yann; Shetty, Dinesh A; Frankel, Steven H

    2013-12-01

    Computational fluid dynamics (CFD) simulations are becoming a reliable tool to understand hemodynamics, disease progression in pathological blood vessels and to predict medical device performance. Immersed boundary method (IBM) emerged as an attractive methodology because of its ability to efficiently handle complex moving and rotating geometries on structured grids. However, its application to study blood flow in complex, branching, patient-specific anatomies is scarce. This is because of the dominance of grid nodes in the exterior of the fluid domain over the useful grid nodes in the interior, rendering an inevitable memory and computational overhead. In order to alleviate this problem, we propose a novel multiblock based IBM that preserves the simplicity and effectiveness of the IBM on structured Cartesian meshes and enables handling of complex, anatomical geometries at a reduced memory overhead by minimizing the grid nodes in the exterior of the fluid domain. As pathological and medical device hemodynamics often involve complex, unsteady transitional or turbulent flow fields, a scale resolving turbulence model such as large eddy simulation (LES) is used in the present work. The proposed solver (here after referred as WenoHemo), is developed by enhancing an existing in-house high order incompressible flow solver that was previously validated for its numerics and several LES models by Shetty et al. [Journal of Computational Physics 2010; 229 (23), 8802-8822]. In the present work, WenoHemo is systematically validated for additional numerics introduced, such as IBM and the multiblock approach, by simulating laminar flow over a sphere and laminar flow over a backward facing step respectively. Then, we validate the entire solver methodology by simulating laminar and transitional flow in abdominal aortic aneurysm (AAA). Finally, we perform blood flow simulations in the challenging clinically relevant thoracic aortic aneurysm (TAA), to gain insights into the type of

  2. Packaging Concerns and Techniques for Large Devices: Challenges for Complex Electronics

    Science.gov (United States)

    LaBel, Kenneth A.; Sampson, Michael J.

    2010-01-01

    NASA is going to have to accept the use of non-hermetic packages for complex devices. There are a large number of packaging options available. Space application subjects the packages to stresses that they were probably not designed for (vacuum for instance). NASA has to find a way of having assurance in the integrity of the packages. There are manufacturers interested in qualifying non-hermetic packages to MIL-PRF-38535 Class V. Government space users are agreed that Class V should be for hermetic packages only. NASA is working on a new Class for non-hermetic packages for M38535 Appendix B, "Class Y". Testing for package integrity will be required but can be package specific as described by a Package Integrity Test Plan. The plan is developed by the manufacturer and approved by DSCC and government space.

  3. An Embedded Boundary Algorithm for Large Eddy Simulations in Complex Geometries

    Directory of Open Access Journals (Sweden)

    Cristian CARLANESCU

    2012-06-01

    Full Text Available The paper presents a novel implementation of the embedded boundary algorithm in a Large Eddy Simulation CFD algorithm. The embedded boundary method aims at allowing the simulation of complex geometry flows on Cartesian computational grids, increasing the numerical accuracy of the method, while maintaining acceptable computational requirements and ease of implementation. The novelty of the present implementation consists in a new method for determining the interpolation points required for computing the state vector at the location required for a correct embedded boundary condition application. The paper also includes method validation results for two flow cases: a laminar Poiseuille flow and laminar and turbulent flows past circular cylinders. The simulation results are in good agreement with the analytical solution (where available and with experimental measurements in the literature.

  4. Hierarchical Modeling and Robust Synthesis for the Preliminary Design of Large Scale Complex Systems

    Science.gov (United States)

    Koch, Patrick N.

    1997-01-01

    Large-scale complex systems are characterized by multiple interacting subsystems and the analysis of multiple disciplines. The design and development of such systems inevitably requires the resolution of multiple conflicting objectives. The size of complex systems, however, prohibits the development of comprehensive system models, and thus these systems must be partitioned into their constituent parts. Because simultaneous solution of individual subsystem models is often not manageable iteration is inevitable and often excessive. In this dissertation these issues are addressed through the development of a method for hierarchical robust preliminary design exploration to facilitate concurrent system and subsystem design exploration, for the concurrent generation of robust system and subsystem specifications for the preliminary design of multi-level, multi-objective, large-scale complex systems. This method is developed through the integration and expansion of current design techniques: Hierarchical partitioning and modeling techniques for partitioning large-scale complex systems into more tractable parts, and allowing integration of subproblems for system synthesis; Statistical experimentation and approximation techniques for increasing both the efficiency and the comprehensiveness of preliminary design exploration; and Noise modeling techniques for implementing robust preliminary design when approximate models are employed. Hierarchical partitioning and modeling techniques including intermediate responses, linking variables, and compatibility constraints are incorporated within a hierarchical compromise decision support problem formulation for synthesizing subproblem solutions for a partitioned system. Experimentation and approximation techniques are employed for concurrent investigations and modeling of partitioned subproblems. A modified composite experiment is introduced for fitting better predictive models across the ranges of the factors, and an approach for

  5. Complex Technique of Large Sural Flap: An Alternative Option for Free Flap in Large Defect of the Traumatized Foot

    Directory of Open Access Journals (Sweden)

    Naser Mohammadkhah

    2011-04-01

    Full Text Available The distally based sural fasciocutaneous flap has become a main part of the reconstruction of the lower leg, heel and foot. However, perfusion problems and venous congestion have been reported. Over the past decade, several flap modifications have been reported to improve flap viability and to solve a myriad of reconstructive needs. The purpose of this paper is to describe our experience in harvesting the reversed large sural flap from the proximal and middle third of the leg for large defects on the foot. We applied the extended reversed sural flap from the proximal third of the leg in traumatized patients which had large defects on their foot. The technique was done in 3 parts: 1- the flaps were designed in the proximal third of the leg five centimeter lipofascial tissue was protected around the pedicle in distal part; 3- The pivot point was located in seven to eight cm proximal the lateral malleolus before the first fasciocutaneous perforators arising from the peroneal artery. Sural flaps from the proximal and middle third of the leg were designed in13 patients who had large defects on their foot. No flap necrosis or split thickness skin graft loss occurred. The flaps healed by the 3rd week excluding two patients. This study supports the application of our technique as a safe, easy and useable method in large defects of the foot. The results showed low rates of ischemia, venous congestion, dehiscence, infection and flap necrosis. Proximal extended and large distally based sural flap is an alternative to free tissue transfer for large defect reconstruction of the foot.

  6. Dynein light chain 1 induces assembly of large Bim complexes on mitochondria that stabilize Mcl-1 and regulate apoptosis.

    Science.gov (United States)

    Singh, Prafull Kumar; Roukounakis, Aristomenis; Frank, Daniel O; Kirschnek, Susanne; Das, Kushal Kumar; Neumann, Simon; Madl, Josef; Römer, Winfried; Zorzin, Carina; Borner, Christoph; Haimovici, Aladin; Garcia-Saez, Ana; Weber, Arnim; Häcker, Georg

    2017-09-01

    The Bcl-2 family protein Bim triggers mitochondrial apoptosis. Bim is expressed in nonapoptotic cells at the mitochondrial outer membrane, where it is activated by largely unknown mechanisms. We found that Bim is regulated by formation of large protein complexes containing dynein light chain 1 (DLC1). Bim rapidly inserted into cardiolipin-containing membranes in vitro and recruited DLC1 to the membrane. Bim binding to DLC1 induced the formation of large Bim complexes on lipid vesicles, on isolated mitochondria, and in intact cells. Native gel electrophoresis and gel filtration showed Bim-containing mitochondrial complexes of several hundred kilodaltons in all cells tested. Bim unable to form complexes was consistently more active than complexed Bim, which correlated with its substantially reduced binding to anti-apoptotic Bcl-2 proteins. At endogenous levels, Bim surprisingly bound only anti-apoptotic Mcl-1 but not Bcl-2 or Bcl-XL, recruiting only Mcl-1 into large complexes. Targeting of DLC1 by RNAi in human cell lines induced disassembly of Bim-Mcl-1 complexes and the proteasomal degradation of Mcl-1 and sensitized the cells to the Bcl-2/Bcl-XL inhibitor ABT-737. Regulation of apoptosis at mitochondria thus extends beyond the interaction of monomers of proapoptotic and anti-apoptotic Bcl-2 family members but involves more complex structures of proteins at the mitochondrial outer membrane, and targeting complexes may be a novel therapeutic strategy. © 2017 Singh et al.; Published by Cold Spring Harbor Laboratory Press.

  7. Large/Complex Antenna Performance Validation for Spaceborne Radar/Radiometeric Instruments

    Science.gov (United States)

    Focardi, Paolo; Harrell, Jefferson; Vacchione, Joseph

    2013-01-01

    Over the past decade, Earth observing missions which employ spaceborne combined radar & radiometric instruments have been developed and implemented. These instruments include the use of large and complex deployable antennas whose radiation characteristics need to be accurately determined over 4 pisteradians. Given the size and complexity of these antennas, the performance of the flight units cannot be readily measured. In addition, the radiation performance is impacted by the presence of the instrument's service platform which cannot easily be included in any measurement campaign. In order to meet the system performance knowledge requirements, a two pronged approach has been employed. The first is to use modeling tools to characterize the system and the second is to build a scale model of the system and use RF measurements to validate the results of the modeling tools. This paper demonstrates the resulting level of agreement between scale model and numerical modeling for two recent missions: (1) the earlier Aquarius instrument currently in Earth orbit and (2) the upcoming Soil Moisture Active Passive (SMAP) mission. The results from two modeling approaches, Ansoft's High Frequency Structure Simulator (HFSS) and TICRA's General RF Applications Software Package (GRASP), were compared with measurements of approximately 1/10th scale models of the Aquarius and SMAP systems. Generally good agreement was found between the three methods but each approach had its shortcomings as will be detailed in this paper.

  8. Large/Complex Antenna Performance Validation for Spaceborne Radar/Radiometeric Instruments

    Science.gov (United States)

    Focardi, Paolo; Harrell, Jefferson; Vacchione, Joseph

    2013-01-01

    Over the past decade, Earth observing missions which employ spaceborne combined radar & radiometric instruments have been developed and implemented. These instruments include the use of large and complex deployable antennas whose radiation characteristics need to be accurately determined over 4 pisteradians. Given the size and complexity of these antennas, the performance of the flight units cannot be readily measured. In addition, the radiation performance is impacted by the presence of the instrument's service platform which cannot easily be included in any measurement campaign. In order to meet the system performance knowledge requirements, a two pronged approach has been employed. The first is to use modeling tools to characterize the system and the second is to build a scale model of the system and use RF measurements to validate the results of the modeling tools. This paper demonstrates the resulting level of agreement between scale model and numerical modeling for two recent missions: (1) the earlier Aquarius instrument currently in Earth orbit and (2) the upcoming Soil Moisture Active Passive (SMAP) mission. The results from two modeling approaches, Ansoft's High Frequency Structure Simulator (HFSS) and TICRA's General RF Applications Software Package (GRASP), were compared with measurements of approximately 1/10th scale models of the Aquarius and SMAP systems. Generally good agreement was found between the three methods but each approach had its shortcomings as will be detailed in this paper.

  9. Tectonic controls on large landslide complex: Williams Fork Mountains near Dillon, Colorado

    Science.gov (United States)

    Kellogg, K.S.

    2001-01-01

    An extensive (~ 25 km2) landslide complex covers a large area on the west side of the Williams Fork Mountains in central Colorado. The complex is deeply weathered and incised, and in most places geomorphic evidence of sliding (breakaways, hummocky topography, transverse ridges, and lobate distal zones) are no longer visible, indicating that the main mass of the slide has long been inactive. However, localized Holocene reactivation of the landslide deposits is common above the timberline (at about 3300 m) and locally at lower elevations. Clasts within the complex, as long as several tens of meters, are entirely of crystalline basement (Proterozoic gneiss and granitic rocks) from the hanging wall of the Laramide (Late Cretaceous to Early Tertiary), west-directed Williams Range thrust, which forms the western structural boundary of the Colorado Front Range. Late Cretaceous shale and sandstone compose most footwall rocks. The crystalline hanging-wall rocks are pervasively fractured or shattered, and alteration to clay minerals is locally well developed. Sackung structures (trenches or small-scale grabens and upslope-facing scarps) are common near the rounded crest of the range, suggesting gravitational spreading of the fractured rocks and oversteepening of the mountain flanks. Late Tertiary and Quaternary incision of the Blue River Valley, just west of the Williams Fork Mountains, contributed to the oversteepening. Major landslide movement is suspected during periods of deglaciation when abundant meltwater increased pore-water pressure in bedrock fractures. A fault-flexure model for the development of the widespread fracturing and weakening of the Proterozoic basement proposes that the surface of the Williams Range thrust contains a concave-downward flexure, the axis of which coincides approximately with the contact in the footwall between Proterozoic basement and mostly Cretaceous rocks. Movement of brittle, hanging-wall rocks through the flexure during Laramide

  10. The Gould's Belt Very Large Array Survey I: The Ophiuchus complex

    CERN Document Server

    Dzib, Sergio A; Mioduszewski, Amy J; Rodríguez, Luis F; Ortiz-León, Gisela N; Pech, Gerardo; Rivera, Juana L; Torres, Rosa M; Boden, Andrew F; Hartmann, Lee; Evans, Neal J; Briceño, Cesar; Tobin, John

    2013-01-01

    We present large-scale ($\\sim$ 2000 square arcminutes), deep ($\\sim$ 20 $\\mu$Jy), high-resolution ($\\sim$ 1$''$) radio observations of the Ophiuchus star-forming complex obtained with the Karl G.\\ Jansky Very Large Array at $\\lambda$ = 4 and 6 cm. In total, 189 sources were detected, 56 of them associated with known young stellar sources, and 4 with known extragalactic objects; the other 129 remain unclassified, but most of them are most probably background quasars. The vast majority of the young stars detected at radio wavelengths have spectral types K or M, although we also detect 4 objects of A/F/B types and 2 brown dwarf candidates. At least half of these young stars are non-thermal (gyrosynchrotron) sources, with active coronas characterized by high levels of variability, negative spectral indices, and (in some cases) significant circular polarization. As expected, there is a clear tendency for the fraction of non-thermal sources to increase from the younger (Class 0/I or flat spectrum) to the more evolv...

  11. THE GOULD's BELT VERY LARGE ARRAY SURVEY. I. THE OPHIUCHUS COMPLEX

    Energy Technology Data Exchange (ETDEWEB)

    Dzib, Sergio A.; Loinard, Laurent; Rodríguez, Luis F.; Ortiz-León, Gisela N.; Pech, Gerardo; Rivera, Juana L. [Centro de Radioastronomía y Astrofísica, Universidad Nacional Autónoma de México Apartado Postal 3-72, 58090 Morelia, Michoacán (Mexico); Mioduszewski, Amy J. [National Radio Astronomy Observatory, Domenici Science Operations Center, 1003 Lopezville Road, Socorro, NM 87801 (United States); Torres, Rosa M. [Paul Harris 9065, Las Condes, Santiago (Chile); Boden, Andrew F. [Division of Physics, Math, and Astronomy, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125 (United States); Hartmann, Lee [Department of Astronomy, University of Michigan, 500 Church Street, Ann Arbor, MI 48105 (United States); Evans, Neal J. II [Department of Astronomy, The University of Texas at Austin, 1 University Station, C1400, Austin, TX 78712 (United States); Briceño, Cesar [Centro de Investigaciones de Astronomía, Mérida 5101-A (Venezuela, Bolivarian Republic of); Tobin, John, E-mail: s.dzib@crya.unam.mx [National Radio Astronomy Observatory, Charlottesville, VA 22903 (United States)

    2013-09-20

    We present large-scale (∼2000 arcmin{sup 2}), deep (∼20 μJy), high-resolution (∼1'') radio observations of the Ophiuchus star-forming complex obtained with the Karl G. Jansky Very Large Array at λ = 4 and 6 cm. In total, 189 sources were detected, 56 of them associated with known young stellar sources, and 4 with known extragalactic objects; the other 129 remain unclassified, but most of them are most probably background quasars. The vast majority of the young stars detected at radio wavelengths have spectral types K or M, although we also detect four objects of A/F/B types and two brown dwarf candidates. At least half of these young stars are non-thermal (gyrosynchrotron) sources, with active coronas characterized by high levels of variability, negative spectral indices, and (in some cases) significant circular polarization. As expected, there is a clear tendency for the fraction of non-thermal sources to increase from the younger (Class 0/I or flat spectrum) to the more evolved (Class III or weak line T Tauri) stars. The young stars detected both in X-rays and at radio wavelengths broadly follow a Güdel-Benz relation, but with a different normalization than the most radioactive types of stars. Finally, we detect a ∼70 mJy compact extragalactic source near the center of the Ophiuchus core, which should be used as gain calibrator for any future radio observations of this region.

  12. An immersed boundary method for direct and large eddy simulation of stratified flows in complex geometry

    Science.gov (United States)

    Rapaka, Narsimha R.; Sarkar, Sutanu

    2016-10-01

    A sharp-interface Immersed Boundary Method (IBM) is developed to simulate density-stratified turbulent flows in complex geometry using a Cartesian grid. The basic numerical scheme corresponds to a central second-order finite difference method, third-order Runge-Kutta integration in time for the advective terms and an alternating direction implicit (ADI) scheme for the viscous and diffusive terms. The solver developed here allows for both direct numerical simulation (DNS) and large eddy simulation (LES) approaches. Methods to enhance the mass conservation and numerical stability of the solver to simulate high Reynolds number flows are discussed. Convergence with second-order accuracy is demonstrated in flow past a cylinder. The solver is validated against past laboratory and numerical results in flow past a sphere, and in channel flow with and without stratification. Since topographically generated internal waves are believed to result in a substantial fraction of turbulent mixing in the ocean, we are motivated to examine oscillating tidal flow over a triangular obstacle to assess the ability of this computational model to represent nonlinear internal waves and turbulence. Results in laboratory-scale (order of few meters) simulations show that the wave energy flux, mean flow properties and turbulent kinetic energy agree well with our previous results obtained using a body-fitted grid (BFG). The deviation of IBM results from BFG results is found to increase with increasing nonlinearity in the wave field that is associated with either increasing steepness of the topography relative to the internal wave propagation angle or with the amplitude of the oscillatory forcing. LES is performed on a large scale ridge, of the order of few kilometers in length, that has the same geometrical shape and same non-dimensional values for the governing flow and environmental parameters as the laboratory-scale topography, but significantly larger Reynolds number. A non-linear drag law

  13. NEW METHOD FOR IMPROVED CALCULATIONS OF UNSTEADY COMPLEX FLOWS IN LARGE ARTERIES

    Institute of Scientific and Technical Information of China (English)

    A. Cheer; Harry A. Dwyer; T. Kim

    2011-01-01

    Using an improved computational fluid dynamics (CFD) method developed for highly unsteady three-dimensional flows,numerical simulations for oscillating flow cycles and detailed unsteady simulations of the flow and forces on the aortic vessels at the iliac bifurcation,for both healthy and diseased patients,are analyzed.Improvements in computational efficiency and acceleration in convergence are achieved by calculating both an unsteady pressure gradient which is due to fluid acceleration and a good global pressure field correction based on mass flow for the pressure Poisson equation.Applications of the enhanced method to oscillatory flow in curved pipes yield an order of magnitude increase in speed and efficiency,thus allowing the study of more complex flow problems such as flow through the mammalian abdominal aorta at the iliac arteries bifurcation.To analyze the large forces which can exist on stent graft of patients with abdominal aortic aneurysm (AAA) disease,a complete derivation of the force equations is presented.The accelerated numerical algorithm and the force equations derived are used to calculate flow and forces for two individuals whose geometry is obtained from CT data and whose respective blood pressure measurements are obtained experimentally.Although the use of endovascular stent grafts in diseased patients can alter vessel geometries,the physical characteristics of stents are still very different when compared to native blood vessels of healthy subjects.The geometry for the AAA stent graph patient studied in this investigation induced flows that resulted in large forces that are primarily caused by the blood pressure.These forces are also directly related to the flow cross-sectional area and the angle of the iliac arteries relative to the main descending aorta.Furthermore,the fluid flow is significantly disturbed in the diseased patient with large flow recirculation and stagnant regions which are not present for healthy subjects.

  14. Large Early Permian eruptive complexes in northern Saxony, Germany: Volcanic facies analysis and geochemical characterization

    Science.gov (United States)

    Hübner, Marcel; Breitkreuz, Christoph; Repstock, Alexander; Heuer, Franziska

    2017-04-01

    In the course of formation of extensional basins during the Early Permian a widespread volcanic activity led to the deposition of volcanic and volcanosedimentary units in Saxony (Walter 2006, Hoffmann et al. 2013). Situated east of Leipzig, the North Saxonian Volcanic Complex (NSVC) hosts two large caldera complexes, the Rochlitz and Wurzen Volcanic Systems, with diameters of 90 and 52 km, respectively. Volume estimates (> 1000 km3) qualify these as supereruptions according to Mason et al. (2004). In addition to the large caldera systems, the NSVC hosts several small pyroclastic flow deposits ranging from crystal-poor (e.g. Cannewitz and vitrophyric Ebersbach ignimbrites) to crystal-rich units (Wermsdorf and Dornreichenbach ignimbrites). Additionally rhyolitic lava and subvolcanic units are present. The Chemnitz basin (Schneider et al. 2012), located to the south of the NSVC, harbours caldera-outflow facies deposits of the Rochlitz eruption (Fischer 1991), i.e. the partially vitrophyric Planitz ignimbrite. The Rochlitz and Wurzen caldera-fill ignimbrites exhibit relatively high crystal contents with maxima up to 52 and 58 vol.-%, for corresponding 66 and 68 wt.-% SiO2. This is comparable with the 'monotonous intermediates' (Hildreth 1981) in the Cenozoic western USA investigated by Huber et al. (2012). In contrast, the Planitz ignimbrite in the Chemnitz basin reveals predominantly crystal-poor pyroclastics ( 70 analyses), and mineral geochemistry to reconstruct the eruption history and magma genesis of this large Late Paleozoic magmatic complex in Central Europe. Volcanic textures and geochemical trends indicate magma mingling and mixing to have been important during the formation of the Wurzen caldera system. Geothermometric and -barometric calculations based on composition of pyroxene and feldspar suggest deeply seated crustal magma chambers for the NSVC and the Planitz ignimbrite. Fischer, F. (1991): Das Rotliegende des ostthüringisch-westsächsischen Raumes

  15. Examining Food Risk in the Large using a Complex, Networked System-of-sytems Approach

    Energy Technology Data Exchange (ETDEWEB)

    Ambrosiano, John [Los Alamos National Laboratory; Newkirk, Ryan [U OF MINNESOTA; Mc Donald, Mark P [VANDERBILT U

    2010-12-03

    The food production infrastructure is a highly complex system of systems. Characterizing the risks of intentional contamination in multi-ingredient manufactured foods is extremely challenging because the risks depend on the vulnerabilities of food processing facilities and on the intricacies of the supply-distribution networks that link them. A pure engineering approach to modeling the system is impractical because of the overall system complexity and paucity of data. A methodology is needed to assess food contamination risk 'in the large', based on current, high-level information about manufacturing facilities, corrunodities and markets, that will indicate which food categories are most at risk of intentional contamination and warrant deeper analysis. The approach begins by decomposing the system for producing a multi-ingredient food into instances of two subsystem archetypes: (1) the relevant manufacturing and processing facilities, and (2) the networked corrunodity flows that link them to each other and consumers. Ingredient manufacturing subsystems are modeled as generic systems dynamics models with distributions of key parameters that span the configurations of real facilities. Networks representing the distribution systems are synthesized from general information about food corrunodities. This is done in a series of steps. First, probability networks representing the aggregated flows of food from manufacturers to wholesalers, retailers, other manufacturers, and direct consumers are inferred from high-level approximate information. This is followed by disaggregation of the general flows into flows connecting 'large' and 'small' categories of manufacturers, wholesalers, retailers, and consumers. Optimization methods are then used to determine the most likely network flows consistent with given data. Vulnerability can be assessed for a potential contamination point using a modified CARVER + Shock model. Once the facility and

  16. World, We Have Problems: Simulation for Large Complex, Risky Projects, and Events

    Science.gov (United States)

    Elfrey, Priscilla

    2010-01-01

    Prior to a spacewalk during the NASA STS/129 mission in November 2009, Columbia Broadcasting System (CBS) correspondent William Harwood reported astronauts, "were awakened again", as they had been the day previously. Fearing something not properly connected was causing a leak, the crew, both on the ground and in space, stopped and checked everything. The alarm proved false. The crew did complete its work ahead of schedule, but the incident reminds us that correctly connecting hundreds and thousands of entities, subsystems and systems, finding leaks, loosening stuck valves, and adding replacements to very large complex systems over time does not occur magically. Everywhere major projects present similar pressures. Lives are at - risk. Responsibility is heavy. Large natural and human-created disasters introduce parallel difficulties as people work across boundaries their countries, disciplines, languages, and cultures with known immediate dangers as well as the unexpected. NASA has long accepted that when humans have to go where humans cannot go that simulation is the sole solution. The Agency uses simulation to achieve consensus, reduce ambiguity and uncertainty, understand problems, make decisions, support design, do planning and troubleshooting, as well as for operations, training, testing, and evaluation. Simulation is at the heart of all such complex systems, products, projects, programs, and events. Difficult, hazardous short and, especially, long-term activities have a persistent need for simulation from the first insight into a possibly workable idea or answer until the final report perhaps beyond our lifetime is put in the archive. With simulation we create a common mental model, try-out breakdowns of machinery or teamwork, and find opportunity for improvement. Lifecycle simulation proves to be increasingly important as risks and consequences intensify. Across the world, disasters are increasing. We anticipate more of them, as the results of global warming

  17. Comprehensive assessment of renal tumour complexity in a large percutaneous cryoablation cohort.

    Science.gov (United States)

    Bhindi, Bimal; Thompson, Robert Houston; Mason, Ross J; Haddad, Mustafa M; Geske, Jennifer R; Kurup, Anil Nicholas; Hannon, James D; Boorjian, Stephen A; Leibovich, Bradley C; Atwell, Thomas D; Schmit, Grant D

    2017-06-01

    To evaluate the association between renal tumour complexity and outcomes in a large cohort of patients undergoing percutaneous cryoablation (PCA). Patients with renal tumours treated with PCA were identified using our prospectively maintained ablation registry (2003-2015). Salvage procedures and inherited tumour syndromes were excluded. The associations between R.E.N.A.L. nephrometry score (NS) and risk of complications, renal function impairment, local failure and cancer-specific mortality (CSM) were evaluated using univariate and multivariable logistic, linear and Cox regression models. The cohort included 618 tumours treated during 580 procedures in 565 patients. The median (interquartile range [IQR]) follow-up was 34 (14.66) months. Complications (any grade) during a procedure (n[total] = 87, 15%) were more frequent with higher NS (NS 4-6: 10%; NS 7-9: 14%; NS 10-12: 36%; P < 0.001). Higher NS was independently associated with risk of complications (odds ratio [OR; per 1 point] = 1.3; 95% confidence interval [CI] 1.2-1.5; P < 0.001). Of all the NS components, tumour size was the most strongly associated with complication risk (OR 3.4; 95% CI 2.2-5.2; P < 0.001). The median (IQR) decline in glomerular filtration rate (GFR) from baseline was 9% (0, 22) at last follow-up. Each additional point in NS was associated with a 1.3% (95% CI 0.4-2.1; P = 0.005) greater GFR decline from baseline. NS was not significantly associated with local failure (n [total] = 14, 2%; NS 4-6: 2%; NS 7-9: 3%; NS 10-12: 5%; P = 0.32) or CSM (n [total] = 8, 2%; NS 4-6: 2%; NS 7-9: 3%; NS 10-12: 2%; P = 0.88). In high-complexity tumours PCA was associated with a tumour size-driven increased risk of post-procedural complications. Higher NS was associated with a small, clinically minor additional decline in renal function. Risks for local failure and CSM were low, regardless of tumour complexity. © 2017 The Authors BJU International © 2017 BJU International Published by John Wiley & Sons

  18. Autologous chondrocyte implantation (ACI for the treatment of large and complex cartilage lesions of the knee

    Directory of Open Access Journals (Sweden)

    Ossendorf Christian

    2011-05-01

    Full Text Available Abstract Background Complex cartilage lesions of the knee including large cartilage defects, kissing lesions, and osteoarthritis (OA represent a common problem in orthopaedic surgery and a challenging task for the orthopaedic surgeon. As there is only limited data, we performed a prospective clinical study to investigate the benefit of autologous chondrocyte implantation (ACI for this demanding patient population. Methods Fifty-one patients displaying at least one of the criteria were included in the present retrospective study: (1. defect size larger than 10 cm2; (2. multiple lesions; (3. kissing lesions, cartilage lesions Outerbridge grade III-IV, and/or (4. mild/moderate osteoarthritis (OA. For outcome measurements, the International Cartilage Society's International Knee Documentation Committee's (IKDC questionnaire, as well as the Cincinnati, Tegner, Lysholm and Noyes scores were used. Radiographic evaluation for OA was done using the Kellgren score. Results and Discussion Patient's age was 36 years (13-61, defects size 7.25 (3-17.5 cm2, previous surgical procedures 1.94 (0-8, and follow-up 30 (12-63 months. Instruments for outcome measurement indicated significant improvement in activity, working ability, and sports. Mean ICRS grade improved from 3.8 preoperatively to grade 3 postoperatively, Tegner grade 1.4 enhanced to grade 3.39. The Cincinnati score enhanced from 25.65 to 66.33, the Lysholm score from 33.26 to 64.68, the Larson score from 43.59 to 79.31, and Noyes score from 12.5 to 46.67, representing an improvement from Cincinnati grade 3.65 to grade 2.1. Lysholm grade 4 improved to grade 3.33, and Larson grade 3.96 to 2.78 (Table 1, (p Table 1 Mean scores and grades at surgery (Tx and at follow-up Tx Follow-up Score Grade Score Grade ICRS 4 3 Tegner 1 3 Noyes 13 47 Cincinnati 26 4 66 2 Lysholm 33 4 65 3 Larson 44 4 79 3 Conclusion Our results suggest that ACI provides mid-term results in patients with complex cartilage lesions of

  19. Including Quantum Effects in the Dynamics of Complex (i.e., Large)Molecular Systems

    Energy Technology Data Exchange (ETDEWEB)

    Miller, William H.

    2006-04-27

    The development in the 1950's and 60's of crossed molecular beam methods for studying chemical reactions at the single-collision molecular level stimulated the need and desire for theoretical methods to describe these and other dynamical processes in molecular systems. Chemical dynamics theory has made great strides in the ensuing decades, so that methods are now available for treating the quantum dynamics of small molecular systems essentially completely. For the large molecular systems that are of so much interest nowadays (e.g. chemical reactions in solution, in clusters, in nano-structures, in biological systems, etc.), however, the only generally available theoretical approach is classical molecular dynamics (MD) simulations. Much effort is currently being devoted to the development of approaches for describing the quantum dynamics of these complex systems. This paper reviews some of these approaches, especially the use of semiclassical approximations for adding quantum effects to classical MD simulations, also showing some new versions that should make these semiclassical approaches even more practical and accurate.

  20. The Gould Belt Very Large Array Survey IV: The Taurus-Auriga complex

    CERN Document Server

    Dzib, Sergio A; Rodríguez, Luis F; Mioduszewski, Amy J; Ortiz-León, Gisela N; Kounkel, Marina A; Pech, Gerardo; Rivera, Juana L; Torres, Rosa M; Boden, Andrew F; Hartmann, Lee; Evans, Neal J; Briceño, Cesar; Tobin, John

    2014-01-01

    We present a multi-epoch radio study of the Taurus-Auriga star-forming complex made with the Karl G. Jansky Very Large Array at frequencies of 4.5 GHz and 7.5 GHz. We detect a total of 610 sources, 59 of which are related to young stellar objects and 18 to field stars. The properties of 56\\% of the young stars are compatible with non-thermal radio emission. We also show that the radio emission of more evolved young stellar objects tends to be more non-thermal in origin and, in general, that their radio properties are compatible with those found in other star forming regions. By comparing our results with previously reported X-ray observations, we notice that young stellar objects in Taurus-Auriga follow a G\\"{u}del-Benz relation with $\\kappa$=0.03, as we previously suggested for other regions of star formation. In general, young stellar objects in Taurus-Auriga and in all the previous studied regions seem to follow this relation with a dispersion of $\\sim1$ dex. Finally, we propose that most of the remaining ...

  1. THE GOULD'S BELT VERY LARGE ARRAY SURVEY. IV. THE TAURUS-AURIGA COMPLEX

    Energy Technology Data Exchange (ETDEWEB)

    Dzib, Sergio A. [Max Planck Institut für Radioastronomie, Auf dem Hügel 69, D-53121 Bonn (Germany); Loinard, Laurent; Rodríguez, Luis F.; Ortiz-León, Gisela N.; Pech, Gerardo; Rivera, Juana L. [Centro de Radioastronomía y Astrofísica, Universidad Nacional Autónoma de México Apartado Postal 3-72, 58090 Morelia, Michoacán (Mexico); Mioduszewski, Amy J. [National Radio Astronomy Observatory, Domenici Science Operations Center, 1003 Lopezville Road, Socorro, NM 87801 (United States); Kounkel, Marina A.; Hartmann, Lee [Department of Astronomy, University of Michigan, 500 Church Street, Ann Arbor, MI 48105 (United States); Torres, Rosa M. [Instituto de Astronomía y Meteorología, Universidad de Guadalajara, Avenida Vallarta No. 2602, Col. Arcos Vallarta, CP 44130 Guadalajara, Jalisco, México (Mexico); Boden, Andrew F. [Division of Physics, Math, and Astronomy, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125 (United States); Evans II, Neal J. [Department of Astronomy, The University of Texas at Austin, 1 University Station, C1400, Austin, TX 78712 (United States); Briceño, Cesar [Cerro Tololo Interamerican Observatory, Casilla 603, La Serena (Chile); Tobin, John, E-mail: sdzib@mpifr-bonn.mpg.de [Leiden Observatory, Leiden University, P.O. Box 9513, 2300 RA Leiden (Netherlands)

    2015-03-10

    We present a multi-epoch radio study of the Taurus-Auriga star-forming complex made with the Karl G. Jansky Very Large Array at frequencies of 4.5 GHz and 7.5 GHz. We detect a total of 610 sources, 59 of which are related to young stellar objects (YSOs) and 18 to field stars. The properties of 56% of the young stars are compatible with non-thermal radio emission. We also show that the radio emission of more evolved YSOs tends to be more non-thermal in origin and, in general, that their radio properties are compatible with those found in other star-forming regions. By comparing our results with previously reported X-ray observations, we notice that YSOs in Taurus-Auriga follow a Güdel-Benz relation with κ = 0.03, as we previously suggested for other regions of star formation. In general, YSOs in Taurus-Auriga and in all the previous studied regions seem to follow this relation with a dispersion of ∼1 dex. Finally, we propose that most of the remaining sources are related with extragalactic objects but provide a list of 46 unidentified radio sources whose radio properties are compatible with a YSO nature.

  2. Formation of Large Polysulfide Complexes during the Lithium-Sulfur Battery Discharge

    Science.gov (United States)

    Wang, Bin; Alhassan, Saeed M.; Pantelides, Sokrates T.

    2014-09-01

    Sulfur cathodes have much larger capacities than transition-metal-oxide cathodes used in commercial lithium-ion batteries but suffer from unsatisfactory capacity retention and long-term cyclability. Capacity degradation originates from soluble lithium polysulfides gradually diffusing into the electrolyte. Understanding of the formation and dynamics of soluble polysulfides during the discharging process at the atomic level remains elusive, which limits further development of lithium-sulfur (Li-S) batteries. Here we report first-principles molecular dynamics simulations and density functional calculations, through which the discharging products of Li-S batteries are studied. We find that, in addition to simple Li2Sn (1≤n ≤8) clusters generated from single cyclooctasulfur (S8) rings, large Li-S clusters form by collectively coupling several different rings to minimize the total energy. At high lithium concentration, a Li-S network forms at the sulfur surfaces. The results can explain the formation of the soluble Li-S complex, such as Li2S8, Li2S6, and Li2S4, and the insoluble Li2S2 and Li2S structures. In addition, we show that the presence of oxygen impurities in graphene, particularly oxygen atoms bonded to vacancies and edges, may stabilize the lithium polysulfides that may otherwise diffuse into the electrolyte.

  3. Probing Titan's Complex Atmospheric Chemistry Using the Atacama Large Millimeter/Submillimeter Array

    Science.gov (United States)

    Cordiner, Martin A.; Nixon, Conor; Charnley, Steven B.; Teanby, Nick; Irwin, Pat; Serigano, Joseph; Palmer, Maureen; Kisiel, Zbigniew

    2015-01-01

    Titan is Saturn's largest moon, with a thick (1.45 bar) atmosphere composed primarily of molecular nitrogen and methane. Atmospheric photochemistry results in the production of a wide range of complex organic molecules, including hydrocarbons, nitriles, aromatics and other species of possible pre-biotic relevance. Titan's carbon-rich atmosphere may be analogous to that of primitive terrestrial planets throughout the universe, yet its origin, evolution and complete chemical inventory are not well understood. Here we present spatially-resolved maps of emission from C2H5CN, HNC, HC3N, CH3CN and CH3CCH in Titan's atmosphere, observed using the Atacama Large Millimeter/submillimeter Array (ALMA) in 2012-2013. These data show previously-undetected spatial structures for the observed species and provide the first spectroscopic detection of C2H5CN on Titan. Our maps show spatially resolved peaks in Titan's northern and southern hemispheres, consistent with photochemical production and transport in the upper atmosphere followed by subsidence over the poles. The HNC emission peaks are offset from the polar axis, indicating that Titan's mesosphere may be more longitudinally variable than previously thought.

  4. Formation of Large Polysulfide Complexes during the Lithium-Sulfur Battery Discharge

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Bin [Vanderbilt University, Nashville; Alhassan, Saeed M. [The Petroleum Institute; Pantelides, Sokrates T [ORNL

    2014-01-01

    Sulfur cathodes have much larger capacities than transition-metal-oxide cathodes used in commercial lithium-ion batteries but suffer from unsatisfactory capacity retention and long-term cyclability. Capacity degradation originates from soluble lithium polysulfides gradually diffusing into the electrolyte. Understanding of the formation and dynamics of soluble polysulfides during the discharging process at the atomic level remains elusive, which limits further development of lithium-sulfur (Li-S) batteries. Here we report first-principles molecular dynamics simulations and density functional calculations, through which the discharging products of Li-S batteries are studied. We find that, in addition to simple Li2Sn (1 n 8) clusters generated from single cyclooctasulfur (S8) rings, large Li-S clusters form by collectively coupling several different rings to minimize the total energy. At high lithium concentration, a Li-S network forms at the sulfur surfaces. The results can explain the formation of the soluble Li-S complex, such as Li2S8, Li2S6, and Li2S4, and the insoluble Li2S2 and Li2S structures. In addition, we show that the presence of oxygen impurities in graphene, particularly oxygen atoms bonded to vacancies and edges, may stabilize the lithium polysulfides that may otherwise diffuse into the electrolyte.

  5. A blind detection of a large, complex, Sunyaev--Zel'dovich structure

    CERN Document Server

    Shimwell, T W; Biddulph, P; Bly, D; Boysen, R C; Brown, A R; Brown, M L; Clementson, C; Crofts, M; Culverhouse, T L; Czeres, J; Dace, R J; Davies, M L; D'Alessandro, R; Doherty, P; Duggan, K; Ely, J A; Felvus, M; Feroz, F; Flynn, W; Franzen, T M O; Geisbusch, J; Genova-Santos, R; Grainge, K J B; Grainger, W F; Hammett, D; Hobson, M P; Holler, C M; Hurley-Walker, N; Jilley, R; Kaneko, T; Kneissl, R; Lancaster, K; Lasenby, A N; Marshall, P J; Newton, F; Norris, O; Northrop, I; Odell, D M; Olamaie, M; Pober, Y C Perrott J C; Pooley, G G; Pospieszalski, M W; Quy, V; Rodriguez-Gonzalvez, C; Saunders, R D E; Scaife, A M M; Schammel, M P; Schofield, J; Scott, P F; Shaw, C; Smith, H; Titterington, D J; Velic, M; Waldram, E M; West, S; Wood, B A; Yassin, G; Zwart, J T L

    2010-01-01

    We present an interesting Sunyaev-Zel'dovich (SZ) detection in the first of the Arcminute Microkelvin Imager (AMI) `blind', degree-square fields to have been observed down to our target sensitivity of 100 microJy/beam. In follow-up deep pointed observations the SZ effect is detected with a maximum peak decrement greater than 8 times the thermal noise. No corresponding emission is visible in the ROSAT all-sky X-ray survey and no cluster is evident in the Palomar all-sky optical survey. Compared with existing SZ images of distant clusters, the extent is large (approximately 10') and complex; our analysis favours a model containing two clusters rather than a single cluster. Our Bayesian analysis is currently limited to modelling each cluster with an ellipsoidal (or spherical) beta-model, which does not do justice to this decrement. Fitting an ellipsoid to the deeper candidate we find the following: (a) Assuming that the Evrard et al. (2002) approximation to Press & Schechter (1974) correctly gives the number...

  6. Small peripheral developing odontoma of the maxilla in a 3-year-old patient depicted on cone-beam tomograms.

    Science.gov (United States)

    Friedrich, Reinhard E; Fuhrmann, Andreas; Scheuer, Hanna A; Zustin, Jozef

    2010-01-01

    A 3-year-old male patient was referred to the Maxillofacial Surgery Clinic due to a painless swelling of the right palatal region. Conventional radiographs revealed no alteration of the dentition and did not delineate a lesion in the region of interest. Cone-beam tomography depicted small radiopaque, extraosseous deposits inside the palatal space. Histological examination revealed a minute mixed epithelial-mesenchymal lesion of odontogenic origin. We made the diagnosis of a peripheral developing odontoma, taking into consideration the components and arrangements of structures of the lesion. Early intervention is advisable to prevent these odontogenic lesions from eventually deforming the jaw and displacing adjacent teeth. Cone-beam tomography was a valuable pre-operative diagnostic tool to assess the lesion as being composed in part of hard tissue.

  7. Design of Complex Systems in the presence of Large Uncertainties: a statistical approach

    Energy Technology Data Exchange (ETDEWEB)

    Koutsourelakis, P

    2007-07-31

    The design or optimization of engineering systems is generally based on several assumptions related to the loading conditions, physical or mechanical properties, environmental effects, initial or boundary conditions etc. The effect of those assumptions to the optimum design or the design finally adopted is generally unknown particularly in large, complex systems. A rational recourse would be to cast the problem in a probabilistic framework which accounts for the various uncertainties but also allows to quantify their effect in the response/behavior/performance of the system. In such a framework the performance function(s) of interest are also random and optimization of the system with respect to the design variables has to be reformulated with respect to statistical properties of these objectives functions (e.g. probability of exceeding certain thresholds). Analysis tools are usually restricted to elaborate legacy codes which have been developed over a long period of time and are generally well-tested (e.g. Finite Elements). These do not however include any stochastic components and their alteration is impossible or ill-advised. Furthermore as the number of uncertainties and design variables grows, the problem quickly becomes computationally intractable. The present paper advocates the use of statistical learning in order to perform these tasks for any system of arbitrary complexity as long as a deterministic solver is available. The proposed computational framework consists of two components. Firstly advanced sampling techniques are employed in order to efficiently explore the dependence of the performance with respect to the uncertain and design variables. The proposed algorithm is directly parallelizable and attempts to maximize the amount of information extracted with the least possible number of calls to the deterministic solver. The output of this process is utilized by statistical classification procedures in order to derive the dependence of the performance

  8. SV40 large T-p53 complex: evidence for the presence of two immunologically distinct forms of p53

    Energy Technology Data Exchange (ETDEWEB)

    Milner, J.; Gamble, J.

    1985-11-01

    The transforming protein of SV40 is the large T antigen. Large T binds a cellular protein, p53, which is potentially oncogenic by virtue of its functional involvement in the control of cell proliferation. This raises the possibility that p53 may mediate, in part, the transforming function of SV40 large T. Two immunologically distinct forms of p53 have been identified in normal cells: the forms are cell-cycle dependent, one being restricted to nondividing cells (p53-Go) and the second to dividing cells (p53-G divided by). The authors have now dissociated and probed the multimeric complex of SV40 large T-p53 for the presence of immunologically distinct forms of p53. Here they present evidence for the presence of p53-Go and p53-G divided by complexed with SV40 large T.

  9. Using very large scale integrated optics (VLSIO) to create high-complexity optoelectronic components

    Science.gov (United States)

    West, Lawrence C.; Roberts, Charles W.; Piscani, Emil C.; Dubey, Madan; Jones, Kenneth A.; McLane, George F.

    1996-01-01

    Optics has the fundamental capability of dramatically improving computer performance via the reduction of capacitance for intrinsic high bandwidth communications and low power usage. Yet optical devices have not displaced silicon VLSI in any measure to date. The reason is clear. When placed into systems, the optical devices have not had significantly greater performance in equally complex information processing circuits and similarly low manufacturing cost. An approach demonstrated here uses the same system integration techniques that have been successful for silicon electronics, only applied to optics. Essential for creation of Very Large Scale Integrated Optics, with over 50,000 high speed logic gates per square centimeter, is a new class of Ultra High Confinement (UHC) waveguides. These waveguides are created with high index difference (as high as 4.0 to 1.0) between guide and cladding. The waveguides have been demonstrated with infrared cross sections less than 5% of a square free space wavelength. These waveguides can be manufactured today only in the mid- infrared, but the concepts should scale to the near-infrared as lithography improves. Waveguide corners have been designed and demonstrated with a bend radius of less than one free space wavelength. Resonators have been designed which have over 100 times smaller volume than VCSELs, yet efficiently interconnected laterally in high densities. A connector to the UHC waveguides has been developed and demonstrated using diffractive optical element arrays on the back side of the substrate. The coupler arrays can allow up to 10,000 Gaussian beam connections per square centimeter. This connectivity also has advantages for low-cost 3D packaging for reduced cost and thermal dissipation. Experimental results on the above concepts and components will be presented.

  10. Metamorphic and thermal evolution of large contact aureoles - lessons from the Bushveld Igneous Complex

    Science.gov (United States)

    Waters, D.

    2012-04-01

    Large igneous intrusions crystallise, cool, and transfer heat out into their host rocks. The thermal structure of the resulting aureole can be mapped as a series of assemblage zones and isograds, and can in principle be modelled on the assumption that heat transfer is dominantly by conduction. The local peak of contact metamorphism occurs later in time with increasing distance from the igneous contact. The importance of fluids as a metamorphic/metasomatic agent or heat transfer mechanism depends on volatile contents of magma and country rock, and on the geometry of the intrusion. Many of these features are spectacularly illustrated by the aureole beneath the mafic Rustenburg Layered Suite of the Bushveld Complex, which was emplaced at ca. 2060 Ma sub-concordantly into the shale-quartzite succession of the Pretoria Group in the Transvaal Basin. The layered suite reaches a thickness of at least 8 km, and the metamorphic aureole extends 4 km or more downwards into the "floor" of the intrusion. The great extent and relative absence of deformation make this a remarkable natural laboratory for studying the fundamental processes of metamorphism. In quantifying the thermal history, however, a number of second-order factors need to be taken into account. The first relates to the markedly different thermal properties of the major quartzite and shale units, and the second to the importance of endothermic metamorphic reactions in shale units relative to the quartzites. Further insights into metamorphic processes arise from the exquisite detail of poikiloblast growth microstructures preserved in graphite-poor metapelites of the Timeball Hill and Silverton Formations, 2.5 to 3.5 km beneath the igneous contact. These allow a detailed reconstruction of the time sequence of mineral growth and replacement, revealing a marked overlap of the growth intervals of porphyroblastic staurolite, cordierite, biotite, garnet and andalusite at the expense of muscovite, chlorite and chloritoid

  11. Large Differences in the Optical Spectrum Associated with the Same Complex: The Effect of the Anisotropy of the Embedding Lattice

    DEFF Research Database (Denmark)

    Aramburu, José Antonio; García-Fernández, Pablo; García Lastra, Juan Maria

    2017-01-01

    of the electric field created by the rest of lattice ions over the complex. To illustrate this concept we analyze the origin of the surprisingly large differences in the d–d optical transitions of two systems containing square-planar CuF42– complexes, CaCuF4, and center II in Cu2+-doped Ba2ZnF6, even though...

  12. Complex processing patterns of mRNAs of the large ATP synthase operon in Arabidopsis chloroplasts.

    Directory of Open Access Journals (Sweden)

    Mustafa Malik Ghulam

    Full Text Available Chloroplasts are photosynthetic cell organelles which have evolved from endosymbiosis of the cyanobacterial ancestor. In chloroplasts, genes are still organized into transcriptional units as in bacteria but the corresponding poly-cistronic mRNAs undergo complex processing events, including inter-genic cleavage and 5' and 3' end-definition. The current model for processing proposes that the 3' end of the upstream cistron transcripts and the 5' end of the downstream cistron transcripts are defined by the same RNA-binding protein and overlap at the level of the protein-binding site. We have investigated the processing mechanisms that operate within the large ATP synthase (atp operon, in Arabidopsis thaliana chloroplasts. This operon is transcribed by the plastid-encoded RNA polymerase starting from two promoters, which are upstream and within the operon, respectively, and harbors four potential sites for RNA-binding proteins. In order to study the functional significance of the promoters and the protein-binding sites for the maturation processes, we have performed a detailed mapping of the atp transcript ends. Our data indicate that in contrast to maize, atpI and atpH transcripts with overlapping ends are very rare in Arabidopsis. In addition, atpA mRNAs, which overlap with atpF mRNAs, are even truncated at the 3' end, thus representing degradation products. We observe, instead, that the 5' ends of nascent poly-cistronic atp transcripts are defined at the first protein-binding site which follows either one of the two transcription initiation sites, while the 3' ends are defined at the subsequent protein-binding sites or at hairpin structures that are encountered by the progressing RNA polymerase. We conclude that the overlapping mechanisms of mRNA protection have only a limited role in obtaining stable processed atp mRNAs in Arabidopsis. Our findings suggest that during evolution of different plant species as maize and Arabidopsis, chloroplasts

  13. Failure of large transformation projects from the viewpoint of complex adaptive systems: Management principles for dealing with project dynamics

    NARCIS (Netherlands)

    Janssen, M.; Voort, H. van der; Veenstra, A.F.E. van

    2015-01-01

    Many large transformation projects do not result in the outcomes desired or envisioned by the stakeholders. This type of project is characterised by dynamics which are both caused by and result of uncertainties and unexpected behaviour. In this paper a complex adaptive system (CAS) view was adopted

  14. Endoscope-assisted repair of large nasal septal perforation using a complex mucoperichondrial flap and free tissue graft

    Institute of Scientific and Technical Information of China (English)

    张庆泉; 张杰; 李树峰

    2003-01-01

    Objective To improve the closure rate of large nasal septal perforations. Methods Using an endoscope, complex mucoperichondrial/mucoperiosteal flaps on one side and free tissue graft on the other, we designed a procedure to repair large nasal septal perforations.Results In our series, 8 patients were operated on with this procedure, resulting in complete closure of the perforation and subsequent relief of symptoms. Conclusion This technique may be used as an alter*$native for the repair of large nasal septal perforations.

  15. Component mode synthesis and large deflection vibration of complex structures. Volume 2: Single-mode large deflection vibrations of beams and plates using finite element method

    Science.gov (United States)

    Mei, Chuh

    1987-01-01

    A finite element method is presented for the large amplitude vibrations of complex structures that can be modelled with beam and rectangular plate elements subjected to harmonic excitation. Both inplane deformation and inertia are considered in the formulation. Derivation of the harmonic force and nonlinear stiffness matrices for a beam and a rectangular plate element are presented. Solution procedures and convergence characteristics of the finite element method are described. Nonlinear response to uniform and concentrated harmonic loadings and improved nonlinear free vibration results are presented for beams and rectangular plates of various boundary conditions.

  16. A developmental framework for complex plasmodesmata formation revealed by large-scale imaging of the Arabidopsis leaf epidermis.

    Science.gov (United States)

    Fitzgibbon, Jessica; Beck, Martina; Zhou, Ji; Faulkner, Christine; Robatzek, Silke; Oparka, Karl

    2013-01-01

    Plasmodesmata (PD) form tubular connections that function as intercellular communication channels. They are essential for transporting nutrients and for coordinating development. During cytokinesis, simple PDs are inserted into the developing cell plate, while during wall extension, more complex (branched) forms of PD are laid down. We show that complex PDs are derived from existing simple PDs in a pattern that is accelerated when leaves undergo the sink-source transition. Complex PDs are inserted initially at the three-way junctions between epidermal cells but develop most rapidly in the anisocytic complexes around stomata. For a quantitative analysis of complex PD formation, we established a high-throughput imaging platform and constructed PDQUANT, a custom algorithm that detected cell boundaries and PD numbers in different wall faces. For anticlinal walls, the number of complex PDs increased with increasing cell size, while for periclinal walls, the number of PDs decreased. Complex PD insertion was accelerated by up to threefold in response to salicylic acid treatment and challenges with mannitol. In a single 30-min run, we could derive data for up to 11k PDs from 3k epidermal cells. This facile approach opens the door to a large-scale analysis of the endogenous and exogenous factors that influence PD formation.

  17. СOMPACT COMPLEX FOR PROCESSING OF LARGE-DIAMETER PIPES INTO THE ROLLING STEEL PRODUCTS

    OpenAIRE

    Steblov, A. В.; A. A. Zlobin

    2016-01-01

    A mini-plant conception for processing of previously used large-diameter pipes into the small-section rolling steel products. Projects with capacity from 15 to 200 thousand tons per year are realized in the UIS.

  18. [The Multipsychometer-01, a multifunctional instrument complex for large-scale psychodiagnostic studies].

    Science.gov (United States)

    Sugoniaev, K V

    1991-01-01

    A large scale personnel testing imposes some specific demands on an apparatus used and it is necessary for developers to take these into account. To bridge a gap between present scientific instruments for psychological research and applied settings, the multifunctional psychodiagnostic system "Multipsychometer-01" adapted for a large scale personnel testing has been developed. The structure, main peculiarities, and some technical parameters of the system are described.

  19. The effect of large amplitude motions on the vibrational intensities in hydrogen bonded complexes

    DEFF Research Database (Denmark)

    Mackeprang, Kasper; Hänninen, Vesa; Halonen, Lauri

    2015-01-01

    We have developed a model to calculate accurately the intensity of the hydrogen bonded XH-stretching vibrational transition in hydrogen bonded complexes. In the Local Mode Perturbation Theory (LMPT) model, the unperturbed system is described by a local mode (LM) model, which is perturbed by the i......We have developed a model to calculate accurately the intensity of the hydrogen bonded XH-stretching vibrational transition in hydrogen bonded complexes. In the Local Mode Perturbation Theory (LMPT) model, the unperturbed system is described by a local mode (LM) model, which is perturbed...... by the intermolecular modes of the hydrogen bonded system that couple with the intramolecular vibrations of the donor unit through the potential energy surface. We have applied the model to three complexes containing water as the donor unit and different acceptor units, providing a series of increasing complex binding...... energy: H2O⋯N2, H2O⋯H2O, and H2O⋯NH3. Results obtained by the LMPT model are presented and compared with calculated results obtained by other vibrational models and with previous results from gas-phase and helium-droplet experiments. We find that the LMPT model reduces the oscillator strengths...

  20. Dual Emissive-Reflective Display Materials with Large Emission Switching Using Highly Luminescent Lanthanide(III) Complex and Electrochromic Material

    Science.gov (United States)

    Kanazawa, Kenji; Nakamura, Kazuki; Kobayashi, Norihisa

    2013-05-01

    Electroswitching of emission and coloration was achieved by a combination of a luminescent Eu(III) complex and an electrochromic molecule of diheptyl viologen (HV2+), in order to utilize them as novel display devices with dual emissive-reflective modes. The coloration was associated with the HV2+ electrochromism. Emission control was also achieved by the HV2+ electrochromism via intermolecular energy transfer from the excited state of the Eu(III) ion to the HV+. In order to improve ON-OFF contrast in emission, the emission quantum yield of Eu(III) complex were considerably improved using low vibrational phosphine oxide ligands, resulting in the large control of emission switching.

  1. The influence of large-amplitude librational motion on the hydrogen bond energy for alcohol–water complexes

    DEFF Research Database (Denmark)

    Andersen, Jonas; Heimdal, J.; Larsen, René Wugt

    2015-01-01

    is a superior hydrogen bond acceptor. The class of large-amplitude donor OH librational motion is shown to account for up to 5.1 kJ mol-1 of the destabilizing change of vibrational zero-point energy upon intermolecular OH...O hydrogen bond formation. The experimental findings are supported by complementary...... unambiguous assignments of the intermolecular high-frequency out-of-plane and low-frequency in-plane donor OH librational modes for mixed alcohol–water complexes. The vibrational assignments confirm directly that water acts as the hydrogen bond donor in the most stable mixed complexes and the tertiary alcohol...

  2. Odontoma localizado dentro del conducto dentario inferior: diagnóstico radiográfico y tratamiento quirúrgico de un caso clínico Odontoma located within the inferior alveolar nerve: radiographic diagnosis and surgical management of a clinical case

    OpenAIRE

    J. Vázquez Diego; C. Gandini Pablo; E. Carbajal Eduardo

    2009-01-01

    Se presenta un caso clínico de odontoma localizado dentro del conducto dentario inferior. El paciente de 54 años de edad es de sexo femenino. Se utiliza la técnica radiográfica panorámica para poder localizar y diagnosticar la afección. Posteriormente se realizó la intervención quirúrgica para extirpar la lesión y se realizó un seguimiento a corto y largo plazo para evaluar la recuperación de la sensibilidad de la zona afectada. El estudio histopatológico confirmó el diagnóstico de odontoma. ...

  3. Automated NMR fragment based screening identified a novel interface blocker to the LARG/RhoA complex.

    Directory of Open Access Journals (Sweden)

    Jia Gao

    Full Text Available The small GTPase cycles between the inactive GDP form and the activated GTP form, catalyzed by the upstream guanine exchange factors. The modulation of such process by small molecules has been proven to be a fruitful route for therapeutic intervention to prevent the over-activation of the small GTPase. The fragment based approach emerging in the past decade has demonstrated its paramount potential in the discovery of inhibitors targeting such novel and challenging protein-protein interactions. The details regarding the procedure of NMR fragment screening from scratch have been rarely disclosed comprehensively, thus restricts its wider applications. To achieve a consistent screening applicable to a number of targets, we developed a highly automated protocol to cover every aspect of NMR fragment screening as possible, including the construction of small but diverse libray, determination of the aqueous solubility by NMR, grouping compounds with mutual dispersity to a cocktail, and the automated processing and visualization of the ligand based screening spectra. We exemplified our streamlined screening in RhoA alone and the complex of the small GTPase RhoA and its upstream guanine exchange factor LARG. Two hits were confirmed from the primary screening in cocktail and secondary screening over individual hits for LARG/RhoA complex, while one of them was also identified from the screening for RhoA alone. HSQC titration of the two hits over RhoA and LARG alone, respectively, identified one compound binding to RhoA.GDP at a 0.11 mM affinity, and perturbed the residues at the switch II region of RhoA. This hit blocked the formation of the LARG/RhoA complex, validated by the native gel electrophoresis, and the titration of RhoA to ¹⁵N labeled LARG in the absence and presence the compound, respectively. It therefore provides us a starting point toward a more potent inhibitor to RhoA activation catalyzed by LARG.

  4. Automated NMR fragment based screening identified a novel interface blocker to the LARG/RhoA complex.

    Science.gov (United States)

    Gao, Jia; Ma, Rongsheng; Wang, Wei; Wang, Na; Sasaki, Ryan; Snyderman, David; Wu, Jihui; Ruan, Ke

    2014-01-01

    The small GTPase cycles between the inactive GDP form and the activated GTP form, catalyzed by the upstream guanine exchange factors. The modulation of such process by small molecules has been proven to be a fruitful route for therapeutic intervention to prevent the over-activation of the small GTPase. The fragment based approach emerging in the past decade has demonstrated its paramount potential in the discovery of inhibitors targeting such novel and challenging protein-protein interactions. The details regarding the procedure of NMR fragment screening from scratch have been rarely disclosed comprehensively, thus restricts its wider applications. To achieve a consistent screening applicable to a number of targets, we developed a highly automated protocol to cover every aspect of NMR fragment screening as possible, including the construction of small but diverse libray, determination of the aqueous solubility by NMR, grouping compounds with mutual dispersity to a cocktail, and the automated processing and visualization of the ligand based screening spectra. We exemplified our streamlined screening in RhoA alone and the complex of the small GTPase RhoA and its upstream guanine exchange factor LARG. Two hits were confirmed from the primary screening in cocktail and secondary screening over individual hits for LARG/RhoA complex, while one of them was also identified from the screening for RhoA alone. HSQC titration of the two hits over RhoA and LARG alone, respectively, identified one compound binding to RhoA.GDP at a 0.11 mM affinity, and perturbed the residues at the switch II region of RhoA. This hit blocked the formation of the LARG/RhoA complex, validated by the native gel electrophoresis, and the titration of RhoA to ¹⁵N labeled LARG in the absence and presence the compound, respectively. It therefore provides us a starting point toward a more potent inhibitor to RhoA activation catalyzed by LARG.

  5. From Collective Knowledge to Intelligence : Pre-Requirements Analysis of Large and Complex Systems

    NARCIS (Netherlands)

    Liang, Peng; Avgeriou, Paris; He, Keqing; Xu, Lai

    2010-01-01

    Requirements engineering is essentially a social collaborative activity in which involved stakeholders have to closely work together to communicate, elicit, negotiate, define, confirm, and finally come up with the requirements for the system to be implemented or upgraded. In the development of large

  6. СOMPACT COMPLEX FOR PROCESSING OF LARGE-DIAMETER PIPES INTO THE ROLLING STEEL PRODUCTS

    Directory of Open Access Journals (Sweden)

    A. В. Steblov

    2016-01-01

    Full Text Available A mini-plant conception for processing of previously used large-diameter pipes into the small-section rolling steel products. Projects with capacity from 15 to 200 thousand tons per year are realized in the UIS.

  7. From Collective Knowledge to Intelligence : Pre-Requirements Analysis of Large and Complex Systems

    NARCIS (Netherlands)

    Liang, Peng; Avgeriou, Paris; He, Keqing; Xu, Lai

    2010-01-01

    Requirements engineering is essentially a social collaborative activity in which involved stakeholders have to closely work together to communicate, elicit, negotiate, define, confirm, and finally come up with the requirements for the system to be implemented or upgraded. In the development of large

  8. Modeling wake effects in large wind farms in complex terrain: the problem, the methods and the issues

    DEFF Research Database (Denmark)

    Politis, E.S.; Prospathopoulos, J.; Cabezon, D.

    2012-01-01

    Computational fluid dynamic (CFD) methods are used in this paper to predict the power production from entire wind farms in complex terrain and to shed some light into the wake flow patterns. Two full three-dimensional Navier–Stokes solvers for incompressible fluid flow, employing k - ε and k - ω...... turbulence closures, are used. The wind turbines are modeled as momentum absorbers by means of their thrust coefficient through the actuator disk approach. Alternative methods for estimating the reference wind speed in the calculation of the thrust are tested. The work presented in this paper is part...... measurements. The focus of the work being carried out is to evaluate the performance of CFD models in large wind farm applications in complex terrain and to examine the development of the wakes in a complex terrain environment....

  9. A method of manufacturing process modeling based on activity network for large-sized and complex products

    Institute of Scientific and Technical Information of China (English)

    LV Min; TONG Zhen-bo; WANG Gang

    2008-01-01

    Simulation technique is an efficient approach to realize the planning and scheduling of manufacturing process of products. An appropriate and efficient manufacturing process model is the basis and key of manufac-turing process simulation. By analyzing the features of large-sized and complex products, a method of manufac-turing process modeling based on activity network is presented and a mapping algorithm of translating BOM/ BOP into the manufacturing process model is designed in detail.

  10. Tomografia computadorizada como método auxiliar no diagnóstico e tratamento de lesões intra-ósseas: caso clínico de odontoma composto = Computed tomography as auxiliary method in the diagnostic and treatment of intra-osseos lesions: a case of compound odontoma

    Directory of Open Access Journals (Sweden)

    Paiano, Grasiela Antunes

    2006-01-01

    Full Text Available O advento da tomografia computadorizada (TC possibilita de visualização tridimensional, favorece o diagnóstico e proporcionando um tratamento mais preciso em virtude da localização exata da lesão e análise da proximidade com as estruturas anatômicas vitais relacionadas. Contudo o tratamento de lesões ósseas se torna mais segura, reduzindo o risco de lesão a dentes adjacentes e nervos. O Odontoma é considerado o tumor odontogênico que mais comumente acomete os ossos maxilares. A variante composta deste tumor apresenta a característica de muitas estruturas semelhantes a dentes envolvidas por um halo radiolúcido e grande freqüência na região anterior da maxila, porém o diagnóstico deste tumor nas demais localizações dos maxilares é pouco freqüente. Apresenta normalmente crescimento limitado e expande as corticais ósseas, porém sem tendência à recidiva. O tratamento do odontoma consiste na sua excisão cirúrgica. Os autores pretendem relatar a utilização da TC como método auxiliar no diagnóstico e tratamento de um caso de exérese de um odontoma composto na região anterior da mandíbula

  11. How to Successfully Incorporate Undergraduate Researchers Into a Complex Research Program at a Large Institution.

    Science.gov (United States)

    Weldon, Rebecca B; Reyna, Valerie F

    2015-01-01

    One feature of the Laboratory for Rational Decision Making at Cornell University is the integration of a large number of undergraduate students into a relatively elaborate research program. We describe our thorough screening process, laboratory structure, and our expectations for undergraduate researchers in our lab. We have a structure in place that helps maintain organization and enhance productivity, including scheduled weekly and monthly meetings, and selecting undergraduate and graduate team leaders to lead each research project. We discuss how it is important to encourage students to aim high and have a good attitude toward learning and problem solving. We emphasize that both initiative and teamwork are important in a large research laboratory. We also discuss the importance of giving students responsibility in connection with research projects-our undergraduate researchers engage in data analysis, interpretation of results, and have a high-level understanding of theory.

  12. Multilevel hierarchical kernel spectral clustering for real-life large scale complex networks.

    Directory of Open Access Journals (Sweden)

    Raghvendra Mall

    Full Text Available Kernel spectral clustering corresponds to a weighted kernel principal component analysis problem in a constrained optimization framework. The primal formulation leads to an eigen-decomposition of a centered Laplacian matrix at the dual level. The dual formulation allows to build a model on a representative subgraph of the large scale network in the training phase and the model parameters are estimated in the validation stage. The KSC model has a powerful out-of-sample extension property which allows cluster affiliation for the unseen nodes of the big data network. In this paper we exploit the structure of the projections in the eigenspace during the validation stage to automatically determine a set of increasing distance thresholds. We use these distance thresholds in the test phase to obtain multiple levels of hierarchy for the large scale network. The hierarchical structure in the network is determined in a bottom-up fashion. We empirically showcase that real-world networks have multilevel hierarchical organization which cannot be detected efficiently by several state-of-the-art large scale hierarchical community detection techniques like the Louvain, OSLOM and Infomap methods. We show that a major advantage of our proposed approach is the ability to locate good quality clusters at both the finer and coarser levels of hierarchy using internal cluster quality metrics on 7 real-life networks.

  13. Methods for the preparation of large quantities of complex single-stranded oligonucleotide libraries.

    Directory of Open Access Journals (Sweden)

    Yusuf E Murgha

    Full Text Available Custom-defined oligonucleotide collections have a broad range of applications in fields of synthetic biology, targeted sequencing, and cytogenetics. Also, they are used to encode information for technologies like RNA interference, protein engineering and DNA-encoded libraries. High-throughput parallel DNA synthesis technologies developed for the manufacture of DNA microarrays can produce libraries of large numbers of different oligonucleotides, but in very limited amounts. Here, we compare three approaches to prepare large quantities of single-stranded oligonucleotide libraries derived from microarray synthesized collections. The first approach, alkaline melting of double-stranded PCR amplified libraries with a biotinylated strand captured on streptavidin coated magnetic beads results in little or no non-biotinylated ssDNA. The second method wherein the phosphorylated strand of PCR amplified libraries is nucleolyticaly hydrolyzed is recommended when small amounts of libraries are needed. The third method combining in vitro transcription of PCR amplified libraries to reverse transcription of the RNA product into single-stranded cDNA is our recommended method to produce large amounts of oligonucleotide libraries. Finally, we propose a method to remove any primer binding sequences introduced during library amplification.

  14. Methods for the preparation of large quantities of complex single-stranded oligonucleotide libraries.

    Science.gov (United States)

    Murgha, Yusuf E; Rouillard, Jean-Marie; Gulari, Erdogan

    2014-01-01

    Custom-defined oligonucleotide collections have a broad range of applications in fields of synthetic biology, targeted sequencing, and cytogenetics. Also, they are used to encode information for technologies like RNA interference, protein engineering and DNA-encoded libraries. High-throughput parallel DNA synthesis technologies developed for the manufacture of DNA microarrays can produce libraries of large numbers of different oligonucleotides, but in very limited amounts. Here, we compare three approaches to prepare large quantities of single-stranded oligonucleotide libraries derived from microarray synthesized collections. The first approach, alkaline melting of double-stranded PCR amplified libraries with a biotinylated strand captured on streptavidin coated magnetic beads results in little or no non-biotinylated ssDNA. The second method wherein the phosphorylated strand of PCR amplified libraries is nucleolyticaly hydrolyzed is recommended when small amounts of libraries are needed. The third method combining in vitro transcription of PCR amplified libraries to reverse transcription of the RNA product into single-stranded cDNA is our recommended method to produce large amounts of oligonucleotide libraries. Finally, we propose a method to remove any primer binding sequences introduced during library amplification.

  15. Bleeding versus Clotting: A Complex Case of a Large Fibroid Uterus Causing Menorrhagia and a DVT

    Directory of Open Access Journals (Sweden)

    Sangeeta Ramanan

    2016-01-01

    Full Text Available A 43-year-old woman presented with severe anaemia secondary to menorrhagia. Pelvic ultrasound showed a large intramural posterior fundal fibroid. Hysteroscopy showed the fibroid distorting the endometrial cavity, precluding Mirena® device insertion. As she was initially hesitant to have a hysterectomy, medical management with the oral contraceptive pill (OCP and tranexamic acid was instituted, with good effect. Months later, after a long road trip, she presented with left leg swelling, and a Doppler ultrasound confirmed an extensive deep vein thrombosis (DVT. She was commenced on warfarin for anticoagulation but presented again with menorrhagia precipitated by overanticoagulation. After initial stabilization with multiple blood transfusions and reversal of anticoagulation, the warfarin was ceased in favour of enoxaparin and she underwent inferior vena cava (IVC filter insertion prior to a total abdominal hysterectomy. Mass effect from large uterine fibroids can cause venous thromboembolism (VTE. A duplex ultrasound of the lower limbs if a woman presents with a large fibroid could identify asymptomatic DVTs in such women. A prehysterectomy IVC filter would then reduce their risk of postoperative pulmonary embolism. Medical management of menorrhagia with procoagulants should be avoided for management of menorrhagia in such women given their higher risk of developing VTE.

  16. Fluid-structure interaction simulation of floating structures interacting with complex, large-scale ocean waves and atmospheric turbulence

    CERN Document Server

    Calderer, Antoni; Shen, Lian; Sotiropoulos, Fotis

    2016-01-01

    We develop a numerical method for simulating coupled interactions of complex floating structures with large-scale ocean waves and atmospheric turbulence. We employ an efficient large-scale model to develop offshore wind and wave environmental conditions, which are then incorporated into a high resolution two-phase flow solver with fluid-structure interaction (FSI). The large-scale wind-wave interaction model is based on the two-fluid dynamically-coupled approach of Yang and Shen (2011), which employs a high-order spectral method for simulating the water motion and a viscous solver with undulatory boundaries for the air motion. The two-phase flow FSI solver, developed by Calderer, Kang, and Sotiropoulos (2014), is based on the level set method and is capable of simulating the coupled dynamic interaction of arbitrarily complex bodies with airflow and waves. The large-scale wave field solver is coupled with the near-field FSI solver by feeding into the latter waves via the pressure-forcing method of Guo and Shen...

  17. A method to compute derivatives of functions of large complex matrices

    CERN Document Server

    Puhr, M

    2016-01-01

    A recently developed numerical method for the calculation of derivatives of functions of general complex matrices, which can also be combined with implicit matrix function approximations such as Krylov-Ritz type algorithms, is presented. An important use case for the method in the context of lattice gauge theory is the overlap Dirac operator at finite quark chemical potential. Derivatives of the lattice Dirac operator are necessary for the computation of conserved lattice currents or the fermionic force in Hybrid Monte-Carlo and Langevin simulations. To calculate the overlap Dirac operator at finite chemical potential the product of the sign function of a non-Hermitian matrix with a vector has to be computed. For non-Hermitian matrices it is not possible to efficiently approximate the sign function with polynomials or rational functions. Implicit approximation algorithms, like Krylov-Ritz methods, that depend on the source vector have to be used instead. Our method can also provide derivatives of such implici...

  18. Large amplitude motion of the acetylene molecule within acetylene-neon complexes hosted in helium droplets.

    Science.gov (United States)

    Briant, M; Mengesha, E; de Pujo, P; Gaveau, M-A; Soep, B; Mestdagh, J-M; Poisson, L

    2016-06-28

    Superfluid helium droplets provide an ideal environment for spectroscopic studies with rotational resolution. Nevertheless, the molecular rotation is hindered because the embedded molecules are surrounded by a non-superfluid component. The present work explores the dynamical role of this component in the hindered rotation of C2H2 within the C2H2-Ne complex. A HENDI experiment was built and near-infrared spectroscopy of C2H2-Ne and C2H2 was performed in the spectral region overlapping the ν3/ν2 + ν4 + ν5 Fermi-type resonance of C2H2. The comparison between measured and simulated spectra helped to address the above issue.

  19. A prototype natural language interface to a large complex knowledge base, the Foundational Model of Anatomy.

    Science.gov (United States)

    Distelhorst, Gregory; Srivastava, Vishrut; Rosse, Cornelius; Brinkley, James F

    2003-01-01

    We describe a constrained natural language interface to a large knowledge base, the Foundational Model of Anatomy (FMA). The interface, called GAPP, handles simple or nested questions that can be parsed to the form, subject-relation-object, where subject or object is unknown. With the aid of domain-specific dictionaries the parsed sentence is converted to queries in the StruQL graph-searching query language, then sent to a server we developed, called OQAFMA, that queries the FMA and returns output as XML. Preliminary evaluation shows that GAPP has the potential to be used in the evaluation of the FMA by domain experts in anatomy.

  20. Large-scale ecological networks do work in an ecologically complex biodiversity hotspot.

    Science.gov (United States)

    Samways, Michael J; Pryke, James S

    2016-03-01

    Landscape-scale ecological networks (ENs) are interconnected conservation corridors of high-quality habitat used to mitigate the adverse effects of landscape fragmentation and to connect with protected areas. The effectiveness of ENs for biodiversity conservation and ecosystem function has been challenged. Here we show how an extensive system of ENs of remnant historic land was put in place at a large spatial scale (>0.5 million ha) in a plantation forestry context in a global biodiversity hotspot in southern Africa. These ENs can maintain indigenous and historic compositional and functional biodiversity, even in an area prone to the challenging effects of El Niño. Furthermore, ENs increase the effective size of local protected areas. Socio-ecological solutions and financial viability are also integrated as part of practical implementation of ENs. By adopting a retrospective analytical approach, biodiversity is maintained while also having productive forestry, making this a powerful agro-ecological approach on a large conservation-significant scale.

  1. De-Duplication Complexity of Fingerprint Data in Large-Scale Applications

    Institute of Scientific and Technical Information of China (English)

    Nalla Pattabhi Ramaiah; C. Krishna Mohan

    2014-01-01

    De-duplication using biometrics has gained much attention from research communities as it provides a unique identity for each and every individual among the large population. De-duplication is the process of removing the instances of multiple enrollments by the same person using the person’s biometric data. An important issue in the large-scale de-duplication applications is the speed of matching and the accuracy of the matching because the number of persons to be enrolled runs into millions. This paper presents an efficient method to improve the accuracy of fingerprint de-duplication in de-centralized manner. De-duplication accuracy decreases because of the noise present in the data, which would cause improper slap fingerprint segmentation. In this paper, an attempt is made to remove the noise present in the data by using binarization of slap fingerprint images and region labeling of desired regions with 8-adjacency neighborhood. The distinct feature of this technique is to remove the noise present in the data for an accurate slap fingerprint segmentation and improve the de-duplica- tion accuracy. Experimental results demonstrate that the fingerprint segmentation rate and de-duplication accuracy are improved significantly.

  2. Max-Min SINR in Large-Scale Single-Cell MU-MIMO: Asymptotic Analysis and Low Complexity Transceivers

    KAUST Repository

    Sifaou, Houssem

    2016-12-28

    This work focuses on the downlink and uplink of large-scale single-cell MU-MIMO systems in which the base station (BS) endowed with M antennas communicates with K single-antenna user equipments (UEs). Particularly, we aim at reducing the complexity of the linear precoder and receiver that maximize the minimum signal-to-interference-plus-noise ratio subject to a given power constraint. To this end, we consider the asymptotic regime in which M and K grow large with a given ratio. Tools from random matrix theory (RMT) are then used to compute, in closed form, accurate approximations for the parameters of the optimal precoder and receiver, when imperfect channel state information (modeled by the generic Gauss-Markov formulation form) is available at the BS. The asymptotic analysis allows us to derive the asymptotically optimal linear precoder and receiver that are characterized by a lower complexity (due to the dependence on the large scale components of the channel) and, possibly, by a better resilience to imperfect channel state information. However, the implementation of both is still challenging as it requires fast inversions of large matrices in every coherence period. To overcome this issue, we apply the truncated polynomial expansion (TPE) technique to the precoding and receiving vector of each UE and make use of RMT to determine the optimal weighting coefficients on a per- UE basis that asymptotically solve the max-min SINR problem. Numerical results are used to validate the asymptotic analysis in the finite system regime and to show that the proposed TPE transceivers efficiently mimic the optimal ones, while requiring much lower computational complexity.

  3. Impactación por odontoma en asociación con alteración de la fórmula dentaria

    Directory of Open Access Journals (Sweden)

    Denia Morales Navarro

    2012-12-01

    Full Text Available Los odontomas son entidades odontogénicas mixtas, compuestas por una mezcla de células odontogénicas epiteliales y mesenquimatosas diferenciadas. Por lo inusual del hecho el objetivo de nuestro trabajo fue presentar un caso de asociación de impactación dentaria por un odontoma con la alteración de la fórmula dental. Se trata de un paciente masculino de 26 años, que acudió a la consulta externa de Cirugía Maxilofacial refiriendo dolor. Al examen físico se detectó asimetría facial por aumento de volumen duro elástico del tercio facial inferior derecho. Al examen físico bucal se observó persistencia del 65 y 85, ausencia clínica del 15, 47 y 48 con expansión de las corticales vestibular y lingual en región mandibular posterior derecha (región molar y retromolar y presencia de una apertura en la mucosa de aproximadamente 8 mm por distal del 46, en la cima del reborde alveolar, de forma redondeada. En el estudio ortopantomográfico se visualizó una imagen radiopaca irregular en sus bordes, de 3cm, asociada a la oligodoncia del 48 e impactación del 47, por lo que se decidió realizar la exéresis quirúrgica de la lesión conjuntamente con el 47, indicándose estudio histopatológico que confirmó la presencia de un odontoma complejo con áreas de tejido blando periférico que mostraban inflamación crónica. El paciente se mantiene bajo seguimiento clínico e imagenológico en su tercer mes postoperatorio. El objetivo de nuestro trabajo fue presentar un caso de asociación de impactación dentaria por un odontoma con la alteración de la fórmula dental.

  4. Clinical features and treatment of ameloblastic fibro-odontoma%成釉细胞纤维牙瘤的临床特点及治疗

    Institute of Scientific and Technical Information of China (English)

    徐峰; 王炳超; 孔丽; 王科; 贾暮云; 袁荣涛

    2016-01-01

    Ameloblastic fibro-odontoma ( AFO) is a rare odontogenic tumor. It often occurrs at the age under twenty, male more than in female. It is mostly located in the maxilla and mandible, and more common in the mandible. It grows slowly with no symptoms. There is asymptomatic swelling in the maxillofacial region and it delays tooth eruption in the case with AFO. X-ray examination always shows a cystic cavity in the jaw, with clear boundary. It is not easy to be differentiated from odontogenic tumors, such as ameloblas-toma and keratocystic odontogenic tumor. Pathological examination shows that neoplasm was composed of proliferating odontogenic epi-thelium in a cellular ectomesenchymal tissue, similar to ameloblastic fibroma in form. Hard tissue component is similar to odontoma, dental structures resembling dentine and enamel-like tissues. It has a low probability of malignancy. The most common treatment is sur-gical removal with low potential for recurrence. In this paper, one case with ameloblastic fibro-odontoma was reported and the clinical features and treatment of ameloblastic fibro-odontoma were investigated.%成釉细胞纤维牙瘤是一种少见的牙源性肿瘤,多发生于20岁以下,男性多于女性,上下颌骨均可发生,多发生于下颌骨,生长缓慢,无自觉症状,常表现为颌面部的肿胀、牙齿迟萌.X线片常见单房改变,表现为边界清楚的囊性透射影,不易与牙源性肿瘤鉴别.组织学表现,软组织成分为牙源性上皮和胚胎性的结缔组织,类似成釉细胞纤维瘤的形态,硬组织成分为牙本质、釉质样组织,类似牙瘤.恶变可能性低,治疗方式为手术摘除,一般不易复发.该文结合我科收治的成釉细胞纤维牙瘤病例,探讨成釉细胞纤维牙瘤的临床特点及治疗与预后.

  5. Evaluating greenhouse gas emissions from hydropower complexes on large rivers in Eastern Washington

    Energy Technology Data Exchange (ETDEWEB)

    Arntzen, Evan V.; Miller, Benjamin L.; O' Toole, Amanda C.; Niehus, Sara E.; Richmond, Marshall C.

    2013-03-15

    Water bodies, such as freshwater lakes, are known to be net emitters of carbon dioxide (CO2), and methane (CH4). In recent years, significant greenhouse gas (GHG) emissions from tropical, boreal, and mid-latitude reservoirs have been reported. At a time when hydropower is increasing worldwide, better understanding of seasonal and regional variation in GHG emissions is needed in order to develop a predictive understanding of such fluxes within man-made impoundments. We examined power-producing dam complexes within xeric temperate locations in the northwestern United States. Sampling environments on the Snake (Lower Monumental Dam Complex) and Columbia Rivers (Priest Rapids Dam Complex) included tributary, mainstem, embayment, forebay, and tailrace areas during winter and summer 2012. At each sampling location, GHG measurement pathways included surface gas flux, degassing as water passed through dams during power generation, ebullition within littoral embayments, and direct sampling of hyporheic pore-water. Measurements were also carried out in a free-flowing reach of the Columbia River to estimate unaltered conditions. Surface flux resulted in very low emissions, with reservoirs acting as a sink for CO2 (up to –262 mg m-2 d-1, which is within the range previously reported for similarly located reservoirs). Surface flux of methane remained below 1 mg CH4 m-2d-1, a value well below fluxes reported previously for temperate reservoirs. Water passing through hydroelectric projects acted as a sink for CO2 during winter and a small source during summer, with mean degassing fluxes of –117 and 4.5 t CO2 d-1, respectively. Degassing of CH4 was minimal, with mean fluxes of 3.1 × 10-6 and –5.6 × 10-4 t CH4 d-1 during winter and summer, respectively. Gas flux due to ebullition was greater in coves located within reservoirs than in coves within the free flowing Hanford Reach–and CH4 flux exceeded that of CO2. Methane emissions varied widely across sampling locations

  6. Large Eddy Simulation of complex sidearms subject to solar radiation and surface cooling.

    Science.gov (United States)

    Dittko, Karl A; Kirkpatrick, Michael P; Armfield, Steven W

    2013-09-15

    Large Eddy Simulation (LES) is used to model two lake sidearms subject to heating from solar radiation and cooling from a surface flux. The sidearms are part of Lake Audrey, NJ, USA and Lake Alexandrina, SA, Australia. The simulation domains are created using bathymetry data and the boundary is modelled with an Immersed Boundary Method. We investigate the cooling and heating phases with separate quasi-steady state simulations. Differential heating occurs in the cavity due to the changing depth. The resulting temperature gradients drive lateral flows. These flows are the dominant transport process in the absence of wind. Study in this area is important in water quality management as the lateral circulation can carry particles and various pollutants, transporting them to and mixing them with the main lake body.

  7. The complex aerodynamic footprint of desert locusts revealed by large-volume tomographic particle image velocimetry.

    Science.gov (United States)

    Henningsson, Per; Michaelis, Dirk; Nakata, Toshiyuki; Schanz, Daniel; Geisler, Reinhard; Schröder, Andreas; Bomphrey, Richard J

    2015-07-01

    Particle image velocimetry has been the preferred experimental technique with which to study the aerodynamics of animal flight for over a decade. In that time, hardware has become more accessible and the software has progressed from the acquisition of planes through the flow field to the reconstruction of small volumetric measurements. Until now, it has not been possible to capture large volumes that incorporate the full wavelength of the aerodynamic track left behind during a complete wingbeat cycle. Here, we use a unique apparatus to acquire the first instantaneous wake volume of a flying animal's entire wingbeat. We confirm the presence of wake deformation behind desert locusts and quantify the effect of that deformation on estimates of aerodynamic force and the efficiency of lift generation. We present previously undescribed vortex wake phenomena, including entrainment around the wing-tip vortices of a set of secondary vortices borne of Kelvin-Helmholtz instability in the shear layer behind the flapping wings.

  8. Large-deformation and long-time behavior of entangled melts in complex geometries

    Science.gov (United States)

    Zhu, Xiangyang; Wang, Shi-Qing

    2012-02-01

    Recent particle-tracking velocimetric (PTV) observations have revealed strain localization either during startup shear beyond the stress overshoot or after a large step shear of entangled polymers [e.g., Macromolecules, 42, 6261 (2009)]. The physical pictures leading to these decohesion events have been put forward [J. Chem. Phys. 127, 064903(2007); J. Rheol. 53, 1389 (2009)]. In this presentation we apply the particle-tracking velocimetric method [Macromol. Mater. Engr. 292, 15 (2007)] to study similar strain localization phenomena originating from yielding of the entanglement network in other forms of deformation including uniaxial extension, ``squeeze flow'' and extrusion of polymers from a wide open space into a narrow opening. The striking discontinuities in the velocity profile can all be understood in terms of a shear yielding criterion. The research is funded, in part, by a grant from the National Science Foundation (CMMI-0926522)

  9. The Design of Large-Scale Complex Engineered Systems: Present Challenges and Future Promise

    Science.gov (United States)

    Bloebaum, Christina L.; McGowan, Anna-Maria Rivas

    2012-01-01

    Model-Based Systems Engineering techniques are used in the SE community to address the need for managing the development of complex systems. A key feature of the MBSE approach is the use of a model to capture the requirements, architecture, behavior, operating environment and other key aspects of the system. The focus on the model differentiates MBSE from traditional SE techniques that may have a document centric approach. In an effort to assess the benefit of utilizing MBSE on its flight projects, NASA Langley has implemented a pilot program to apply MBSE techniques during the early phase of the Materials International Space Station Experiment-X (MISSE-X). MISSE-X is a Technology Demonstration Mission being developed by the NASA Office of the Chief Technologist i . Designed to be installed on the exterior of the International Space Station (ISS), MISSE-X will host experiments that advance the technology readiness of materials and devices needed for future space exploration. As a follow-on to the highly successful series of previous MISSE experiments on ISS, MISSE-X benefits from a significant interest by the

  10. Large-Scale CO Maps of the Lupus Molecular Cloud Complex

    CERN Document Server

    Tothill, N F H; Parshley, S C; Stark, A A; Lane, A P; Harnett, J I; Wright, G A; Walker, C K; Bourke, T L; Myers, P C

    2009-01-01

    Fully sampled degree-scale maps of the 13CO 2-1 and CO 4-3 transitions toward three members of the Lupus Molecular Cloud Complex - Lupus I, III, and IV - trace the column density and temperature of the molecular gas. Comparison with IR extinction maps from the c2d project requires most of the gas to have a temperature of 8-10 K. Estimates of the cloud mass from 13CO emission are roughly consistent with most previous estimates, while the line widths are higher, around 2 km/s. CO 4-3 emission is found throughout Lupus I, indicating widespread dense gas, and toward Lupus III and IV. Enhanced line widths at the NW end and along the edge of the B228 ridge in Lupus I, and a coherent velocity gradient across the ridge, are consistent with interaction between the molecular cloud and an expanding HI shell from the Upper-Scorpius subgroup of the Sco-Cen OB Association. Lupus III is dominated by the effects of two HAe/Be stars, and shows no sign of external influence. Slightly warmer gas around the core of Lupus IV and ...

  11. A Lanczos eigenvalue method on a parallel computer. [for large complex space structure free vibration analysis

    Science.gov (United States)

    Bostic, Susan W.; Fulton, Robert E.

    1987-01-01

    Eigenvalue analyses of complex structures is a computationally intensive task which can benefit significantly from new and impending parallel computers. This study reports on a parallel computer implementation of the Lanczos method for free vibration analysis. The approach used here subdivides the major Lanczos calculation tasks into subtasks and introduces parallelism down to the subtask levels such as matrix decomposition and forward/backward substitution. The method was implemented on a commercial parallel computer and results were obtained for a long flexible space structure. While parallel computing efficiency is problem and computer dependent, the efficiency for the Lanczos method was good for a moderate number of processors for the test problem. The greatest reduction in time was realized for the decomposition of the stiffness matrix, a calculation which took 70 percent of the time in the sequential program and which took 25 percent of the time on eight processors. For a sample calculation of the twenty lowest frequencies of a 486 degree of freedom problem, the total sequential computing time was reduced by almost a factor of ten using 16 processors.

  12. APINetworks Java. A Java approach to the efficient treatment of large-scale complex networks

    Science.gov (United States)

    Muñoz-Caro, Camelia; Niño, Alfonso; Reyes, Sebastián; Castillo, Miriam

    2016-10-01

    We present a new version of the core structural package of our Application Programming Interface, APINetworks, for the treatment of complex networks in arbitrary computational environments. The new version is written in Java and presents several advantages over the previous C++ version: the portability of the Java code, the easiness of object-oriented design implementations, and the simplicity of memory management. In addition, some additional data structures are introduced for storing the sets of nodes and edges. Also, by resorting to the different garbage collectors currently available in the JVM the Java version is much more efficient than the C++ one with respect to memory management. In particular, the G1 collector is the most efficient one because of the parallel execution of G1 and the Java application. Using G1, APINetworks Java outperforms the C++ version and the well-known NetworkX and JGraphT packages in the building and BFS traversal of linear and complete networks. The better memory management of the present version allows for the modeling of much larger networks.

  13. Heritability and demographic analyses in the large isolated population of Val Borbera suggest advantages in mapping complex traits genes.

    Directory of Open Access Journals (Sweden)

    Michela Traglia

    Full Text Available BACKGROUND: Isolated populations are a useful resource for mapping complex traits due to shared stable environment, reduced genetic complexity and extended Linkage Disequilibrium (LD compared to the general population. Here we describe a large genetic isolate from the North West Apennines, the mountain range that runs through Italy from the North West Alps to the South. METHODOLOGY/PRINCIPAL FINDINGS: The study involved 1,803 people living in 7 villages of the upper Borbera Valley. For this large population cohort, data from genealogy reconstruction, medical questionnaires, blood, anthropometric and bone status QUS parameters were evaluated. Demographic and epidemiological analyses indicated a substantial genetic component contributing to each trait variation as well as overlapping genetic determinants and family clustering for some traits. CONCLUSIONS/SIGNIFICANCE: The data provide evidence for significant heritability of medical relevant traits that will be important in mapping quantitative traits. We suggest that this population isolate is suitable to identify rare variants associated with complex phenotypes that may be difficult to study in larger but more heterogeneous populations.

  14. Analytic model for the complex effective index dispersion of metamaterial-cladding large-area hollow core fibers.

    Science.gov (United States)

    Zeisberger, Matthias; Tuniz, Alessandro; Schmidt, Markus A

    2016-09-05

    We present a mathematical model that allows interpreting the dispersion and attenuation of modes in hollow-core fibers (HCFs) on the basis of single interface reflection, giving rise to analytic and semi-analytic expressions for the complex effective indices in the case where the core diameter is large and the guiding is based on the reflection by a thin layer. Our model includes two core-size independent reflection parameters and shows the universal inverse-cubed core diameter dependence of the modal attenuation of HCFs. It substantially reduces simulation complexity and enables large scale parameter sweeps, which we demonstrate on the example of a HCF with a highly anisotropic metallic nanowire cladding, resembling an indefinite metamaterial at high metal filling fractions. We reveal design rules that allow engineering modal discrimination and show that metamaterial HCFs can principally have low losses at mid-IR wavelengths (model can be applied to a great variety of HCFs with large core diameters and can be used for advanced HCF design and performance optimization, in particular with regard to dispersion engineering and modal discrimination.

  15. Sphincterotomy plus large balloon dilation versus sphincterotomy alone for the extraction of complex lithiasis: a prospective analysis

    Directory of Open Access Journals (Sweden)

    Martín Alejandro Guidi

    2015-08-01

    Full Text Available Background and purpose: Mid-size sphincterotomy associated with large balloon dilation is an alternative to wide sphincterotomy to remove complex lithiases. However, which of the two techniques is most effective remains unclear. Hence, we conducted this study to compare both methods prospectively. Method: Since January 2012 until March 2014, 133 consecutive patients with complex stones were included. Group A underwent mid-size sphincterotomy associated with large balloon dilation and group B underwent wide sphincterotomy alone. Success rates were assessed for: Extraction of stones, ductal patency rate, the use of mechanical lithotripsy, dose, time and dose per radioscopy area as well as procedure-related complications. Results: Group A comprised 44 patients and group B comprised 69 patients. Overall success rate for extraction was 86.4% in group A and 70% in group B (p = 0.069. In giant lithiasis, effective extraction was 89.3% in group A and 58.6% in group B (p = 0.019. Use of mechanical lithotripsy was 15.9% and 30.4%, respectively (p = 0.142. Total radiotherapy dose was 39.8 mGy vs. 26.2 mGy, respectively (p = 0.134. Complications occurred in 6.8% and 5.5% of the procedures in each group, without significant differences among them (p = 0.856. Conclusion: Sphincterotomy plus large balloon dilation is more effective and equally safe than conventional sphincterotomy for the management of giant main bile duct lithiasis.

  16. Reconstruction of Holocene carbon dynamics in a large boreal peatland complex, southern Finland

    Science.gov (United States)

    Mathijssen, Paul J. H.; Väliranta, Minna; Korrensalo, Aino; Alekseychik, Pavel; Vesala, Timo; Rinne, Janne; Tuittila, Eeva-Stiina

    2016-06-01

    Holocene peatland development and associated carbon (C) dynamics were reconstructed for a southern boreal Finnish peatland complex with fen and bog areas. In order to assess the role of local factors and long-term allogenic climate forcing in peatland development patterns, we studied a total of 18 peat cores and reconstructed vertical peat growth and lateral peat area expansion rates, the C accumulation rate (CAR), past vegetation composition and past methane (CH4) fluxes. We combined fossil plant data with measured contemporary CH4 flux - vegetation relationship data to reconstruct CH4 fluxes over time. When these reconstructions were added to the CAR estimations, a more complete picture of Holocene-scale C dynamics was achieved. Basal peat ages showed that expansion of the peat area was rapid between 11,000 and 8000 cal. BP, but decreased during the dry mid-Holocene and is probably currently limited by basal topography. A similar pattern was observed for peat growth and CAR in the fen core, whereas in the bog core CAR increased after ombrotrophication, i.e. after 4400 cal. BP. The effect of fire on vegetation and CAR was more conspicuous at the bog site than at the fen site. The CH4 flux reconstructions showed that during the Holocene CH4 emissions at the fen site decreased from 19 ± 15 to 16 ± 8 g CH4 m-2 yr-1 and at the bog site from 20 ± 15 to 14 ± 8 g CH4 m-2 yr-1. Our results suggest that a combination of changing climate, fire events and local conditions have modified the autogenic peatland development and C dynamics.

  17. Tidal energy resource complexity in a large strait: The Karori Rip, Cook Strait

    Science.gov (United States)

    Stevens, C. L.; Smith, M. J.; Grant, B.; Stewart, C. L.; Divett, T.

    2012-02-01

    Successful extraction of tidal stream energy will require a good understanding of flow at a range of scales, including those relating to average energy, variability in energy supply and fatigue. Current and turbulence measurements from the Karori Rip area of Cook Strait, the prime focal region of open-water tidal stream electricity generation in New Zealand, are described. A key issue is that a significant portion of the energy is contained in waters deeper than normally considered for energy extraction. Here we compare shallow and deep sites. Velocity data were derived from acoustic Doppler current profiler moorings, as well as spatial surveys and show flow magnitudes reaching 3.4 m s -1 in the shallow regions. The maximum speeds in both shallow and deep sites were typically located in the upper part of the measured water column although moored acoustic Doppler current profiler (ADCP) observations showed some complexity in this regard. Benthic boundary-layers were resolved in the bottom ˜20 m of the water column. Measured turbulent kinetic energy dissipation rates ɛ exceeded 10 -5 m 2 s -3 and estimated maximum ɛ is a factor of 10 greater. This was not distributed evenly through the water column, with stratification and velocity shear clearly persisting, especially around the turn of the tide. The implications for tidal stream energy are that (i) there is sufficient energy resource in the region for a moderate sized array of turbines, (ii) the vertical variability in the flow speed suggests turbines that can operate near the surface would be more effective at accessing the resource, (iii) stratification may persist and influence the scales of turbulence and (iv) wave-current interaction effects will influence any near-surface structure as well as vessel operations.

  18. Large, detergent-resistant complexes containing murine antigens Thy-1 and Ly-6 and protein tyrosine kinase p56lck.

    Science.gov (United States)

    Bohuslav, J; Cinek, T; Horejsí, V

    1993-04-01

    A number of human and mouse leukocyte surface (glyco)proteins anchored in a membrane via glycosylphosphatidylinositol (GPI) moiety have been previously shown to be noncovalently associated with protein tyrosine kinases (Science 1991. 254: 1016; J. Biol. Chem. 1992. 267: 12317). Here we show that two murine antigens of this group, Thy-1 and Ly-6, implicated in the activation of the T cells, are associated with each other, with the kinase p56lck and with several of potential kinase substrates in very large, detergent-resistant complexes, the size of which is between 50 and 200 nm, as determined by ultrafiltration and gel chromatography. Experiments on simultaneous solubilization of mixed human and mouse cells rule out that the observed complexes are artifacts induced by the detergent. Complexes of similar composition and properties were obtained when either detergents Brij-58, Nonidet-P40 or 3-[(3-cholamidopropyl)-dimethylammonio]- 1-propane-sulfonate (Chaps) were used for solubilization of the cells, while octylglucoside at least partially dissociated them. These "GPI-complexes" may be essential for the well-known signal-transducing capacity of Thy-1 and Ly-6.

  19. "Best Practices in Using Large, Complex Samples: The Importance of Using Appropriate Weights and Design Effect Compensation"

    Directory of Open Access Journals (Sweden)

    Jason W. Osborne

    2011-09-01

    Full Text Available Large surveys often use probability sampling in order to obtain representative samples, and these data sets are valuable tools for researchers in all areas of science. Yet many researchers are not formally prepared to appropriately utilize these resources. Indeed, users of one popular dataset were generally found not to have modeled the analyses to take account of the complex sample (Johnson & Elliott, 1998 even when publishing in highly-regarded journals. It is well known that failure to appropriately model the complex sample can substantially bias the results of the analysis. Examples presented in this paper highlight the risk of error of inference and mis-estimation of parameters from failure to analyze these data sets appropriately.

  20. Computation of scattering matrix elements of large and complex shaped absorbing particles with multilevel fast multipole algorithm

    Science.gov (United States)

    Wu, Yueqian; Yang, Minglin; Sheng, Xinqing; Ren, Kuan Fang

    2015-05-01

    Light scattering properties of absorbing particles, such as the mineral dusts, attract a wide attention due to its importance in geophysical and environment researches. Due to the absorbing effect, light scattering properties of particles with absorption differ from those without absorption. Simple shaped absorbing particles such as spheres and spheroids have been well studied with different methods but little work on large complex shaped particles has been reported. In this paper, the surface Integral Equation (SIE) with Multilevel Fast Multipole Algorithm (MLFMA) is applied to study scattering properties of large non-spherical absorbing particles. SIEs are carefully discretized with piecewise linear basis functions on triangle patches to model whole surface of the particle, hence computation resource needs increase much more slowly with the particle size parameter than the volume discretized methods. To improve further its capability, MLFMA is well parallelized with Message Passing Interface (MPI) on distributed memory computer platform. Without loss of generality, we choose the computation of scattering matrix elements of absorbing dust particles as an example. The comparison of the scattering matrix elements computed by our method and the discrete dipole approximation method (DDA) for an ellipsoid dust particle shows that the precision of our method is very good. The scattering matrix elements of large ellipsoid dusts with different aspect ratios and size parameters are computed. To show the capability of the presented algorithm for complex shaped particles, scattering by asymmetry Chebyshev particle with size parameter larger than 600 of complex refractive index m = 1.555 + 0.004 i and different orientations are studied.

  1. Complex Nucleation Process of Large North Chile Earthquakes, Implications for Early Warning Systems

    Science.gov (United States)

    Ruiz, S.; Meneses, G.; Sobiesiak, M.; Madariaga, R. I.

    2014-12-01

    We studied the nucleation process of Northern Chile events that included the large earthquakes of Tocopilla 2007 Mw 7.8 and Iquique 2014 Mw 8.1, as well as the background seismicity recorded from 2011 to 2013 by the ILN temporary network and the IPOC and CSN permanent networks. We built our catalogue of 393 events starting from the CSN catalogue, which has a completeness of magnitude Mw > 3.0 in Northern Chile. We re-located and computed moment magnitude for each event. We also computed Early Warning (EW) parameters - Pd, Pv, τc and IV2 - for each event including 13 earthquakes of Mw>6.0 that occurred between 2007-2012. We also included part of the seismicity from March-April 2014 period. We find that Pd, Pv and IV2 are good estimators of magnitude for interplate thrust and intraplate intermediate depth events with Mw between 4.0 and 6.0. However, the larger magnitude events show a saturation of the EW parameters. The Tocopilla 2007 and Iquique 2014 earthquake sequences were studied in detail. Almost all events with Mw>6.0 present precursory signals so that the largest amplitudes occur several seconds after the first P wave arrival. The recent Mw 8.1 Iquique 2014 earthquake was preceded by low amplitude P waves for 20 s before the main asperity was broken. The magnitude estimation can improve if we consider longer P wave windows in the estimation of EW parameters. There was, however, a practical limit during the Iquique earthquake because the first S waves arrived before the arrival of the P waves from the main rupture. The 4 s P-wave Pd parameter estimated Mw 7.1 for the Mw 8.1 Iquique 2014 earthquake and Mw 7.5 for the Mw 7.8 Tocopilla 2007 earthquake.

  2. METHOD FOR QUICKLY INFERRING THE MECHANISMS OF LARGE-SCALE COMPLEX NETWORKS BASED ON THE CENSUS OF SUBGRAPH CONCENTRATIONS

    Institute of Scientific and Technical Information of China (English)

    Bo YANG; Xiaorong CHEN

    2009-01-01

    A Mechanism-Inferring method of networks exploited from machine learning theory can effectively evaluate the predicting performance of a network model. The existing method for inferring network mechanisms based on a census of subgraph numbers has some drawbacks, especially the need for a runtime increasing strongly with network size and network density. In this paper, an improved method has been proposed by introducing a census algorithm of subgraph concentrations. Network mechanism can be quickly inferred by the new method even though the network has large scale and high density. Therefore, the application perspective of mechanism-inferring method has been extended into the wider fields of large-scale complex networks. By applying the new method to a case of protein interaction network, the authors obtain the same inferring result as the existing method, which approves the effectiveness of the method.

  3. NdhP is an exclusive subunit of large complex of NADPH dehydrogenase essential to stabilize the complex in Synechocystis sp. strain PCC 6803.

    Science.gov (United States)

    Zhang, Jingsong; Gao, Fudan; Zhao, Jiaohong; Ogawa, Teruo; Wang, Quanxi; Ma, Weimin

    2014-07-04

    Two major complexes of NADPH dehydrogenase (NDH-1) have been identified in cyanobacteria. A large complex (NDH-1L) contains NdhD1 and NdhF1, which are absent in a medium size complex (NDH-1M). They play important roles in respiration, cyclic electron transport around photosystem I, and CO2 acquisition. Two mutants sensitive to high light for growth and impaired in NDH-1-mediated cyclic electron transfer were isolated from Synechocystis sp. strain PCC 6803 transformed with a transposon-bearing library. Both mutants had a tag in sml0013 encoding NdhP, a single transmembrane small subunit of the NDH-1 complex. During prolonged incubation of the wild type thylakoid membrane with n-dodecyl β-d-maltoside (DM), about half of the NDH-1L was disassembled to NDH-1M and the rest decomposed completely without forming NDH-1M. In the ndhP deletion mutant (ΔndhP), disassembling of NDH-1L to NDH-1M occurred even on ice, and decomposition to a small piece occurred at room temperature much faster than in the wild type. Deletion of the C-terminal tail of NdhP gave the same result. The C terminus of NdhP was tagged by YFP-His6. Blue native gel electrophoresis of the DM-treated thylakoid membrane of this strain and Western analysis using the antibody against GFP revealed that NdhP-YFP-His6 was exclusively confined to NDH-1L. During prolonged incubation of the thylakoid membrane of the tagged strain with DM at room temperature, NDH-1L was partially disassembled to NDH-1M and the 160-kDa band containing NdhP-YFP-His6 and possibly NdhD1 and NdhF1. We therefore conclude that NdhP, especially its C-terminal tail, is essential to assemble NdhD1 and NdhF1 and stabilize the NDH-1L complex. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

  4. Complexity

    CERN Document Server

    Gershenson, Carlos

    2011-01-01

    The term complexity derives etymologically from the Latin plexus, which means interwoven. Intuitively, this implies that something complex is composed by elements that are difficult to separate. This difficulty arises from the relevant interactions that take place between components. This lack of separability is at odds with the classical scientific method - which has been used since the times of Galileo, Newton, Descartes, and Laplace - and has also influenced philosophy and engineering. In recent decades, the scientific study of complexity and complex systems has proposed a paradigm shift in science and philosophy, proposing novel methods that take into account relevant interactions.

  5. AtMic60 Is Involved in Plant Mitochondria Lipid Trafficking and Is Part of a Large Complex.

    Science.gov (United States)

    Michaud, Morgane; Gros, Valérie; Tardif, Marianne; Brugière, Sabine; Ferro, Myriam; Prinz, William A; Toulmay, Alexandre; Mathur, Jaideep; Wozny, Michael; Falconet, Denis; Maréchal, Eric; Block, Maryse A; Jouhet, Juliette

    2016-03-07

    The mitochondrion is an organelle originating from an endosymbiotic event and playing a role in several fundamental processes such as energy production, metabolite syntheses, and programmed cell death. This organelle is delineated by two membranes whose synthesis requires an extensive exchange of phospholipids with other cellular organelles such as endoplasmic reticulum (ER) and vacuolar membranes in yeast. These transfers of phospholipids are thought to occur by a non-vesicular pathway at contact sites between two closely apposed membranes. In plants, little is known about the biogenesis of mitochondrial membranes. Contact sites between ER and mitochondria are suspected to play a similar role in phospholipid trafficking as in yeast, but this has never been demonstrated. In contrast, it has been shown that plastids are able to transfer lipids to mitochondria during phosphate starvation. However, the proteins involved in such transfer are still unknown. Here, we identified in Arabidopsis thaliana a large lipid-enriched complex called the mitochondrial transmembrane lipoprotein (MTL) complex. The MTL complex contains proteins located in the two mitochondrial membranes and conserved in all eukaryotic cells, such as the TOM complex and AtMic60, a component of the MICOS complex. We demonstrate that AtMic60 contributes to the export of phosphatidylethanolamine from mitochondria and the import of galactoglycerolipids from plastids during phosphate starvation. Furthermore, AtMic60 promotes lipid desorption from membranes, likely as an initial step for lipid transfer, and binds to Tom40, suggesting that AtMic60 could regulate the tethering between the inner and outer membranes of mitochondria.

  6. Large Size Color-tunable Electroluminescence from Cationic Iridium Complexes-based Light-emitting Electrochemical Cells

    Science.gov (United States)

    Zeng, Qunying; Li, Fushan; Guo, Tailiang; Shan, Guogang; Su, Zhongmin

    2016-06-01

    Solution-processable light-emitting electrochemical cells (LECs) with simple device architecture have become an attractive candidate for application in next generation lighting and flat-panel displays. Herein, single layer LECs employing two cationic Ir(III) complexes showing highly efficient blue-green and yellow electroluminescence with peak current efficiency of 31.6 cd A‑1 and 40.6 cd A‑1, respectively, have been reported. By using both complexes in the device, color-tunable LECs with a single spectral peak in the wavelength range from 499 to 570 nm were obtained by varying their rations. In addition, the fabrication of efficient LECs was demonstrated based on low cost doctor-blade coating technique, which was compatible with the roll to roll fabrication process for the large size production. In this work, for the first time, 4 inch LEC devices by doctor-blade coating were fabricated, which exhibit the efficiencies of 23.4 cd A‑1 and 25.4 cd A‑1 for the blue-green and yellow emission, respectively. The exciting results indicated that highly efficient LECs with controllable color could be realized and find practical application in large size lighting and displays.

  7. Tail-scope: Using friends to estimate heavy tails of degree distributions in large-scale complex networks

    CERN Document Server

    Eom, Young-Ho

    2014-01-01

    Many complex networks in natural and social phenomena have often been characterized by heavy-tailed degree distributions. However, due to rapidly growing size of network data and concerns on privacy issues about using these data, it becomes more difficult to analyze complete data sets. Thus, it is crucial to devise effective and efficient estimation methods for heavy tails of degree distributions in large-scale networks only using local information of a small fraction of sampled nodes. Here we propose a tail-scope method based on local observational bias of the friendship paradox. We show that the tail-scope method outperforms the uniform node sampling for estimating heavy tails of degree distributions, while the opposite tendency is observed in the range of small degrees. In order to take advantages of both sampling methods, we devise the hybrid method that successfully recovers the whole range of degree distributions. Our tail-scope method shows how structural heterogeneities of large-scale complex networks...

  8. Tail-scope: Using friends to estimate heavy tails of degree distributions in large-scale complex networks

    Science.gov (United States)

    Eom, Young-Ho; Jo, Hang-Hyun

    2015-05-01

    Many complex networks in natural and social phenomena have often been characterized by heavy-tailed degree distributions. However, due to rapidly growing size of network data and concerns on privacy issues about using these data, it becomes more difficult to analyze complete data sets. Thus, it is crucial to devise effective and efficient estimation methods for heavy tails of degree distributions in large-scale networks only using local information of a small fraction of sampled nodes. Here we propose a tail-scope method based on local observational bias of the friendship paradox. We show that the tail-scope method outperforms the uniform node sampling for estimating heavy tails of degree distributions, while the opposite tendency is observed in the range of small degrees. In order to take advantages of both sampling methods, we devise the hybrid method that successfully recovers the whole range of degree distributions. Our tail-scope method shows how structural heterogeneities of large-scale complex networks can be used to effectively reveal the network structure only with limited local information.

  9. Multi-Dimensional Analysis of Large, Complex Slope Instability: Case study of Downie Slide, British Columbia, Canada. (Invited)

    Science.gov (United States)

    Kalenchuk, K. S.; Hutchinson, D.; Diederichs, M. S.

    2013-12-01

    Downie Slide, one of the world's largest landslides, is a massive, active, composite, extremely slow rockslide located on the west bank of the Revelstoke Reservoir in British Columbia. It is a 1.5 billion m3 rockslide measuring 2400 m along the river valley, 3300m from toe to headscarp and up to 245 m thick. Significant contributions to the field of landslide geomechanics have been made by analyses of spatially and temporally discriminated slope deformations, and how these are controlled by complex geological and geotechnical factors. Downie Slide research demonstrates the importance of delineating massive landslides into morphological regions in order to characterize global slope behaviour and identify localized events, which may or may not influence the overall slope deformation patterns. Massive slope instabilities do not behave as monolithic masses, rather, different landslide zones can display specific landslide processes occurring at variable rates of deformation. The global deformation of Downie Slide is extremely slow moving; however localized regions of the slope incur moderate to high rates of movement. Complex deformation processes and composite failure mechanism are contributed to by topography, non-uniform shear surfaces, heterogeneous rockmass and shear zone strength and stiffness characteristics. Further, from the analysis of temporal changes in landslide behaviour it has been clearly recognized that different regions of the slope respond differently to changing hydrogeological boundary conditions. State-of-the-art methodologies have been developed for numerical simulation of large landslides; these provide important tools for investigating dynamic landslide systems which account for complex three-dimensional geometries, heterogenous shear zone strength parameters, internal shear zones, the interaction of discrete landslide zones and piezometric fluctuations. Numerical models of Downie Slide have been calibrated to reproduce observed slope behaviour

  10. Planning and Building Qualifiable Embedded Systems: Safety and Risk Properties Assessment for a Large and Complex System with Embedded Subsystems

    Science.gov (United States)

    Silva, N.; Lopes, R.; Barbosa, R.

    2012-01-01

    Systems based on embedded components and applications are today used in all markets. They are planned and developed by all types of institutions with different types of background experience, multidisciplinary teams and all types of capability and maturity levels. Organisational/engineering maturity has an impact on all aspects of the engineering of large and complex systems. An embedded system is a specific computer system designed to perform one or more dedicated functions, usually with real-time constraints. It is generally integrated as part of a more complex device typically composed of specific hardware such as sensors and actuators. This article presents an experimented technique to evaluate the organisation, processes, system and software engineering practices, methods, tools and the planned/produced artefacts themselves, leading towards certification/qualification. The safety and risk assessment of such core and complex systems is explained, described on a step-by- step manner, while presenting the main results and conclusions of the application of the technique to a real case study.

  11. Near-infrared Polarimetric Study of the N159/N160 Star-forming Complex in the Large Magellanic Cloud

    Science.gov (United States)

    Kim, Jaeyeong; Jeong, Woong-Seob; Pyo, Jeonghyun; Pak, Soojong; Park, Won-Kee; Kwon, Jungmi; Tamura, Motohide

    2017-03-01

    We present near-infrared polarimetric results for the N159/N160 star-forming complex in the Large Magellanic Cloud with SIRPOL, the polarimeter of the Infrared Survey Facility. We separated foreground sources using their visual extinction derived from near-infrared photometric data. The 45 young stellar candidates and 2 high-excitation blobs were matched with our sources, and 12 of them showed high polarization that did not originate from the interstellar dust. We made a polarimetric catalog of 252, 277, and 89 sources at the J, H, and K s bands, respectively. Based on the ratios of the polarization degree between these bands, we verify that the origin of these polarized sources is the dichroic extinction from the interstellar dust aligned by the magnetic field and that the ratios follow a power-law dependence of {P}λ ∼ {λ }-0.9. The linear polarization vectors projected onto the Hα image of the complex turned out to follow the local magnetic field structure. The vector map overlaid on dust and gas emissions shows the close correlation between the magnetic field structure and surrounding interstellar medium. We suggest that the derived magnetic field structure supports the sequential formation scenario of the complex.

  12. Geophysical analysis of the Alpha-Mendeleev ridge complex: Characterization of the High Arctic Large Igneous Province

    Science.gov (United States)

    Oakey, G. N.; Saltus, R. W.

    2016-11-01

    The Alpha-Mendeleev ridge complex is a first-order physiographic and geological feature of the Arctic Amerasia Basin. High amplitude "chaotic" magnetic anomalies (the High Arctic Magnetic High Domain or HAMH) are associated with the complex and extend beyond the bathymetric high beneath the sediment cover of the adjacent Canada and Makarov-Podvodnikov basins. Residual marine Bouguer gravity anomalies over the ridge complex have low amplitudes implying that the structure has minimal lateral density variability. A closed pseudogravity (magnetic potential) contour around the ridge complex quantifies the aerial extent of the HAMH at 1.3 × 106 km2. We present 2D gravity/magnetic models for transects across the Alpha Ridge portion of the complex constrained with recently acquired seismic reflection and refraction data. The crustal structure is modeled with a simple three-layer geometry. Large induced and remanent magnetization components were required to fit the observed magnetic anomalies. Density values for the models were based on available seismic refraction P-wave velocities. The 3000 kg/m3 lower crustal layer is interpreted as a composite of the original crustal protolith and deep (ultramafic) plutonic intrusions related to a plume sourced (High Arctic) LIP. The 2900 kg/m3 mid-crustal and 2600 kg/m3 upper-crustal layers are interpreted as the combined effect of sills, dikes, and flows. Volumetric estimates of the volcanic composition include (at least) 6 × 106 km3 for the mid- and upper-crust and between 13 × 106 and 17 × 106 km3 within the lower crust - for a total of 20 × 106 km3. We compare the magnetic structure, pseudogravity, and volumetric estimates for the HAMH portion of the HALIP with global large igneous province analogs and discuss implications for Arctic tectonics. Our results show that the closest analog to the HAMH/HALIP is the Kerguelen Plateau, which is considered a continental plateau intensively modified by plume-related volcanism.

  13. Complex

    African Journals Online (AJOL)

    CLEMENT O BEWAJI

    Schiff bases and their complex compounds have been studied for their .... establishing coordination of the N–(2 – hydroxybenzyl) - L - α - valine Schiff base ..... (1967); “Spectrophotometric Identification of Organic Compounds”, Willey, New.

  14. A Framework of Working Across Disciplines in Early Design and R&D of Large Complex Engineered Systems

    Science.gov (United States)

    McGowan, Anna-Maria Rivas; Papalambros, Panos Y.; Baker, Wayne E.

    2015-01-01

    This paper examines four primary methods of working across disciplines during R&D and early design of large-scale complex engineered systems such as aerospace systems. A conceptualized framework, called the Combining System Elements framework, is presented to delineate several aspects of cross-discipline and system integration practice. The framework is derived from a theoretical and empirical analysis of current work practices in actual operational settings and is informed by theories from organization science and engineering. The explanatory framework may be used by teams to clarify assumptions and associated work practices, which may reduce ambiguity in understanding diverse approaches to early systems research, development and design. The framework also highlights that very different engineering results may be obtained depending on work practices, even when the goals for the engineered system are the same.

  15. Gamma rays from atomic and molecular gas in the large complex of clouds in Orion and Monoceros

    Science.gov (United States)

    Bloemen, J. B. G. M.; Caraveo, P. A.; Hermsen, W.; Lebrun, F.; Maddalena, R. J.; Strong, A. W.; Thaddeus, P.

    1984-01-01

    A comparison of COS-B gamma-ray observations of the large complex of interstellar clouds in Orion and Monoceros with the Columbia CO and Berkeley H I surveys of this region reveals a good correlation between gamma-ray emission and total gas distribution. The observed gamma-ray emission is explainable in terms of interactions of cosmic rays that are uniformly distributed in this region with the interstellar gas. The correlation is used as the basis of a calibration of the ratio between H2 column density and the integrated CO line intensity; the value of (2.6 + or - 1.2) X 10 to the 20th mol/sq cm K km s thereby obtained is consistent with the value derived from a similar analysis for the inner galaxy.

  16. MEGAHIT: an ultra-fast single-node solution for large and complex metagenomics assembly via succinct de Bruijn graph.

    Science.gov (United States)

    Li, Dinghua; Liu, Chi-Man; Luo, Ruibang; Sadakane, Kunihiko; Lam, Tak-Wah

    2015-05-15

    MEGAHIT is a NGS de novo assembler for assembling large and complex metagenomics data in a time- and cost-efficient manner. It finished assembling a soil metagenomics dataset with 252 Gbps in 44.1 and 99.6 h on a single computing node with and without a graphics processing unit, respectively. MEGAHIT assembles the data as a whole, i.e. no pre-processing like partitioning and normalization was needed. When compared with previous methods on assembling the soil data, MEGAHIT generated a three-time larger assembly, with longer contig N50 and average contig length; furthermore, 55.8% of the reads were aligned to the assembly, giving a fourfold improvement.

  17. Large-Eddy-Simulation-based analysis of complex flow structures within the volute of a vaneless centrifugal pump

    Indian Academy of Sciences (India)

    TAIMOOR ASIM; RAKESH MISHRA

    2017-04-01

    Centrifugal pumps are very common in many fluid handling industrial applications, such as petrochemicals, oil and gas, etc. Although the design practices for centrifugal pumps are well established, efforts are directed towards optimising such systems for better operational efficiencies. In order to optimally design centrifugal pumps, it is beneficial to first understand the complex flow phenomena within different sections of the pump for a variety of operating conditions. This is normally achieved through the use of modern techniques,such as Computational Fluid Dynamics (CFD), where the flow within centrifugal pumps can be numerically modelled and important flow features can be analysed for better understanding of interactions amongst different process variables. CFD offers different turbulence modelling techniques with an aim to predict realistic flow approximations. Large Eddy Simulation (LES) offers a more accurate solution to this, in which the larger eddies are resolved while smaller eddies are modelled; hence predictions using LES are more realistic. Further, in turbulence modelling within centrifugal pumps, it is also important to model the complete interaction amongst different variables rather than a simplistic single blade passage flow analysis. In the present work, the complex blade–tongue interactions and their consequent effects on the pressure fluctuations within the volute have been evaluated. It is seen that the secondary flow features in the near-tongue regions due to blade interactions with the tongue affect the flow characteristics within the volute considerably.

  18. Low Complexity Precoder and Receiver Design for Massive MIMO Systems: A Large System Analysis using Random Matrix Theory

    KAUST Repository

    Sifaou, Houssem

    2016-05-01

    Massive MIMO systems are shown to be a promising technology for next generations of wireless communication networks. The realization of the attractive merits promised by massive MIMO systems requires advanced linear precoding and receiving techniques in order to mitigate the interference in downlink and uplink transmissions. This work considers the precoder and receiver design in massive MIMO systems. We first consider the design of the linear precoder and receiver that maximize the minimum signal-to-interference-plus-noise ratio (SINR) subject to a given power constraint. The analysis is carried out under the asymptotic regime in which the number of the BS antennas and that of the users grow large with a bounded ratio. This allows us to leverage tools from random matrix theory in order to approximate the parameters of the optimal linear precoder and receiver by their deterministic approximations. Such a result is of valuable practical interest, as it provides a handier way to implement the optimal precoder and receiver. To reduce further the complexity, we propose to apply the truncated polynomial expansion (TPE) concept on a per-user basis to approximate the inverse of large matrices that appear on the expressions of the optimal linear transceivers. Using tools from random matrix theory, we determine deterministic approximations of the SINR and the transmit power in the asymptotic regime. Then, the optimal per-user weight coe cients that solve the max-min SINR problem are derived. The simulation results show that the proposed precoder and receiver provide very close to optimal performance while reducing signi cantly the computational complexity. As a second part of this work, the TPE technique in a per-user basis is applied to the optimal linear precoding that minimizes the transmit power while satisfying a set of target SINR constraints. Due to the emerging research eld of green cellular networks, such a problem is receiving increasing interest nowadays. Closed

  19. A large-scale RF-based Indoor Localization System Using Low-complexity Gaussian filter and improved Bayesian inference

    Directory of Open Access Journals (Sweden)

    L. Xiao

    2013-04-01

    Full Text Available The growing convergence among mobile computing device and smart sensors boosts the development of ubiquitous computing and smart spaces, where localization is an essential part to realize the big vision. The general localization methods based on GPS and cellular techniques are not suitable for tracking numerous small size and limited power objects in the indoor case. In this paper, we propose and demonstrate a new localization method, this method is an easy-setup and cost-effective indoor localization system based on off-the-shelf active RFID technology. Our system is not only compatible with the future smart spaces and ubiquitous computing systems, but also suitable for large-scale indoor localization. The use of low-complexity Gaussian Filter (GF, Wheel Graph Model (WGM and Probabilistic Localization Algorithm (PLA make the proposed algorithm robust and suitable for large-scale indoor positioning from uncertainty, self-adjective to varying indoor environment. Using MATLAB simulation, we study the system performances, especially the dependence on a number of system and environment parameters, and their statistical properties. The simulation results prove that our proposed system is an accurate and cost-effective candidate for indoor localization.

  20. Ultrabright fluorescent silica particles with a large number of complex spectra excited with a single wavelength for multiplex applications.

    Science.gov (United States)

    Palantavida, S; Peng, B; Sokolov, I

    2017-02-08

    We report on a novel approach to synthesize ultrabright fluorescent silica particles capable of producing a large number of complex spectra. The spectra can be excited using a single wavelength which is paramount in quantitative fluorescence imaging, flow cytometry and sensing applications. The approach employs the physical encapsulation of organic fluorescent molecules inside a nanoporous silica matrix with no dye leakage. As was recently demonstrated, such an encapsulation allowed for the encapsulation of very high concentrations of organic dyes without quenching their fluorescent efficiency. As a result, dye molecules are distanced within ∼5 nm from each other; it theoretically allows for efficient exchange of excitation energy via Förster resonance energy transfer (FRET). Here we present the first experimental demonstration of the encapsulation of fluorescent dyes in the FRET sequence. Attaining a FRET sequence of up to five different dyes is presented. The number of distinguishable spectra can be further increased by using different relative concentrations of encapsulated dyes. Combining these approaches allows for creating a large number of ultrabright fluorescent particles with substantially different fluorescence spectra. We also demonstrate the utilization of these particles for potential multiplexing applications. Though fluorescence spectra of the obtained multiplex probes are typically overlapping, they can be distinguished by using standard linear decomposition algorithms.

  1. Par@Graph – a parallel toolbox for the construction and analysis of large complex climate networks

    Directory of Open Access Journals (Sweden)

    H. Ihshaish

    2015-01-01

    Full Text Available In this paper, we present Par@Graph, a software toolbox to reconstruct and analyze complex climate networks having a large number of nodes (up to at least O (106 and of edges (up to at least O (1012. The key innovation is an efficient set of parallel software tools designed to leverage the inherited hybrid parallelism in distributed-memory clusters of multi-core machines. The performance of the toolbox is illustrated through networks derived from sea surface height (SSH data of a global high-resolution ocean model. Less than 8 min are needed on 90 Intel Xeon E5-4650 processors to construct a climate network including the preprocessing and the correlation of 3 × 105 SSH time series, resulting in a weighted graph with the same number of vertices and about 3 × 106 edges. In less than 5 min on 30 processors, the resulted graph's degree centrality, strength, connected components, eigenvector centrality, entropy and clustering coefficient metrics were obtained. These results indicate that a complete cycle to construct and analyze a large-scale climate network is available under 13 min. Par@Graph therefore facilitates the application of climate network analysis on high-resolution observations and model results, by enabling fast network construction from the calculation of statistical similarities between climate time series. It also enables network analysis at unprecedented scales on a variety of different sizes of input data sets.

  2. Evolution of DNA ligases of Nucleo-Cytoplasmic Large DNA viruses of eukaryotes: a case of hidden complexity

    Directory of Open Access Journals (Sweden)

    Koonin Eugene V

    2009-12-01

    Full Text Available Abstract Background Eukaryotic Nucleo-Cytoplasmic Large DNA Viruses (NCLDV encode most if not all of the enzymes involved in their DNA replication. It has been inferred that genes for these enzymes were already present in the last common ancestor of the NCLDV. However, the details of the evolution of these genes that bear on the complexity of the putative ancestral NCLDV and on the evolutionary relationships between viruses and their hosts are not well understood. Results Phylogenetic analysis of the ATP-dependent and NAD-dependent DNA ligases encoded by the NCLDV reveals an unexpectedly complex evolutionary history. The NAD-dependent ligases are encoded only by a minority of NCLDV (including mimiviruses, some iridoviruses and entomopoxviruses but phylogenetic analysis clearly indicated that all viral NAD-dependent ligases are monophyletic. Combined with the topology of the NCLDV tree derived by consensus of trees for universally conserved genes suggests that this enzyme was represented in the ancestral NCLDV. Phylogenetic analysis of ATP-dependent ligases that are encoded by chordopoxviruses, most of the phycodnaviruses and Marseillevirus failed to demonstrate monophyly and instead revealed an unexpectedly complex evolutionary trajectory. The ligases of the majority of phycodnaviruses and Marseillevirus seem to have evolved from bacteriophage or bacterial homologs; the ligase of one phycodnavirus, Emiliana huxlei virus, belongs to the eukaryotic DNA ligase I branch; and ligases of chordopoxviruses unequivocally cluster with eukaryotic DNA ligase III. Conclusions Examination of phyletic patterns and phylogenetic analysis of DNA ligases of the NCLDV suggest that the common ancestor of the extant NCLDV encoded an NAD-dependent ligase that most likely was acquired from a bacteriophage at the early stages of evolution of eukaryotes. By contrast, ATP-dependent ligases from different prokaryotic and eukaryotic sources displaced the ancestral NAD

  3. Development of Quality Assessment Techniques for Large Eddy Simulation of Propulsion and Power Systems in Complex Geometries

    Energy Technology Data Exchange (ETDEWEB)

    Lacaze, Guilhem [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Oefelein, Joseph [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-03-01

    Large-eddy-simulation (LES) is quickly becoming a method of choice for studying complex thermo-physics in a wide range of propulsion and power systems. It provides a means to study coupled turbulent combustion and flow processes in parameter spaces that are unattainable using direct-numerical-simulation (DNS), with a degree of fidelity that can be far more accurate than conventional engineering methods such as the Reynolds-averaged Navier-Stokes (RANS) approx- imation. However, development of predictive LES is complicated by the complex interdependence of different type of errors coming from numerical methods, algorithms, models and boundary con- ditions. On the other hand, control of accuracy has become a critical aspect in the development of predictive LES for design. The objective of this project is to create a framework of metrics aimed at quantifying the quality and accuracy of state-of-the-art LES in a manner that addresses the myriad of competing interdependencies. In a typical simulation cycle, only 20% of the computational time is actually usable. The rest is spent in case preparation, assessment, and validation, because of the lack of guidelines. This work increases confidence in the accuracy of a given solution while min- imizing the time obtaining the solution. The approach facilitates control of the tradeoffs between cost, accuracy, and uncertainties as a function of fidelity and methods employed. The analysis is coupled with advanced Uncertainty Quantification techniques employed to estimate confidence in model predictions and calibrate model's parameters. This work has provided positive conse- quences on the accuracy of the results delivered by LES and will soon have a broad impact on research supported both by the DOE and elsewhere.

  4. Exergy and extended exergy accounting of very large complex systems with an application to the province of Siena, Italy.

    Science.gov (United States)

    Sciubba, Enrico; Bastianoni, Simone; Tiezzi, Enzo

    2008-01-01

    This paper describes the application of exergy and extended exergy analyses to large complex systems. The system to be analysed is assumed to be at steady state, and the input and output fluxes of matter and energy are expressed in units of exergy. Human societies of any reasonable extent are indeed Very Large Complex Systems and can be represented as interconnected networks of N elementary "components", their Subsystems; the detail of the disaggregation depends on the type and quality of the available data. The structural connectivity of the "model" of the System must correctly describe the interactions of each mass or energy flow with each sector of the society: since it is seldom the case that all of these fluxes are available in detail, some preliminary mass- and energy balances must be completed and constitute in fact a part of the initial assumptions. Exergy accounting converts the total amount of resources inflow into their equivalent exergetic form with the help of a table of "raw exergy data" available in the literature. The quantification of each flow on a homogeneous exergetic basis paves the way to the evaluation of the efficiency of each energy and mass transfer between the N sectors and makes it possible to quantify the irreversible losses and identify their sources. The advantage of the EEA, compared to a classical exergy accounting, is the inclusion in the system balance of the exergetic equivalents of three additional "Production Factors": human Labour, Capital and Environmental Remediation costs. EEA has an additional advantage: it allows for the calculation of the efficiency of the domestic sector (impossible to evaluate with any other energy- or exergy-based method) by considering the working hours as its product. As implied in the title, an application of the method was made to a model of the province of Siena (on a year 2000 database): the results show that the sectors of this Province have values of efficiency close to the Italian average

  5. Joining inventory by parataxonomists with DNA barcoding of a large complex tropical conserved wildland in northwestern Costa Rica.

    Directory of Open Access Journals (Sweden)

    Daniel H Janzen

    Full Text Available BACKGROUND: The many components of conservation through biodiversity development of a large complex tropical wildland, Area de Conservacion Guanacaste (ACG, thrive on knowing what is its biodiversity and natural history. For 32 years a growing team of Costa Rican parataxonomists has conducted biodiversity inventory of ACG caterpillars, their food plants, and their parasitoids. In 2003, DNA barcoding was added to the inventory process. METHODOLOGY/PRINCIPAL FINDINGS: We describe some of the salient consequences for the parataxonomists of barcoding becoming part of a field biodiversity inventory process that has centuries of tradition. From the barcoding results, the parataxonomists, as well as other downstream users, gain a more fine-scale and greater understanding of the specimens they find, rear, photograph, database and deliver. The parataxonomists also need to adjust to collecting more specimens of what appear to be the "same species"--cryptic species that cannot be distinguished by eye or even food plant alone--while having to work with the name changes and taxonomic uncertainty that comes with discovering that what looked like one species may be many. CONCLUSIONS/SIGNIFICANCE: These career parataxonomists, despite their lack of formal higher education, have proven very capable of absorbing and working around the additional complexity and requirements for accuracy and detail that are generated by adding barcoding to the field base of the ACG inventory. In the process, they have also gained a greater understanding of the fine details of phylogeny, relatedness, evolution, and species-packing in their own tropical complex ecosytems. There is no reason to view DNA barcoding as incompatible in any way with tropical biodiversity inventory as conducted by parataxonomists. Their year-round on-site inventory effort lends itself well to the sampling patterns and sample sizes needed to build a thorough barcode library. Furthermore, the biological

  6. Compound odontoma associated with impacted maxillary central incisor dictates a need to be vigilant to canine eruption pattern: A 2-year follow-up

    Science.gov (United States)

    Singla, Shilpy; Gupta, Sachin

    2016-01-01

    Canine deviation from its path of eruption is usually followed by either delayed or impaction of canine. One of the important and not so noticed reasons for canine displacement is formerly impacted central incisor. The difference in age of eruption of these two teeth is 4 years; however, the absence of maxillary incisor should be perceived with utmost conviction about impending canine displacement leading to its impaction as well. This case presents similar picture where composite, compound odontoma with respect to maxillary central incisor led to its impaction resulted in deviated path of eruption for erupting canine. This canine displacement to worsen prognosis ended up getting impacted if not dealt with cautiously in the later stages of occlusal development. PMID:27307685

  7. Compound odontoma associated with impacted maxillary central incisor dictates a need to be vigilant to canine eruption pattern: A 2-year follow-up

    Directory of Open Access Journals (Sweden)

    Shilpy Singla

    2016-01-01

    Full Text Available Canine deviation from its path of eruption is usually followed by either delayed or impaction of canine. One of the important and not so noticed reasons for canine displacement is formerly impacted central incisor. The difference in age of eruption of these two teeth is 4 years; however, the absence of maxillary incisor should be perceived with utmost conviction about impending canine displacement leading to its impaction as well. This case presents similar picture where composite, compound odontoma with respect to maxillary central incisor led to its impaction resulted in deviated path of eruption for erupting canine. This canine displacement to worsen prognosis ended up getting impacted if not dealt with cautiously in the later stages of occlusal development.

  8. Compound odontoma associated with impacted maxillary central incisor dictates a need to be vigilant to canine eruption pattern: A 2-year follow-up.

    Science.gov (United States)

    Singla, Shilpy; Gupta, Sachin

    2016-01-01

    Canine deviation from its path of eruption is usually followed by either delayed or impaction of canine. One of the important and not so noticed reasons for canine displacement is formerly impacted central incisor. The difference in age of eruption of these two teeth is 4 years; however, the absence of maxillary incisor should be perceived with utmost conviction about impending canine displacement leading to its impaction as well. This case presents similar picture where composite, compound odontoma with respect to maxillary central incisor led to its impaction resulted in deviated path of eruption for erupting canine. This canine displacement to worsen prognosis ended up getting impacted if not dealt with cautiously in the later stages of occlusal development.

  9. A numerical approach for simulating fluid structure interaction of flexible thin shells undergoing arbitrarily large deformations in complex domains

    Energy Technology Data Exchange (ETDEWEB)

    Gilmanov, Anvar, E-mail: agilmano@umn.edu [Saint Anthony Falls Laboratory, University of Minnesota, Minneapolis, MN 55414 (United States); Le, Trung Bao, E-mail: lebao002@umn.edu [Saint Anthony Falls Laboratory, University of Minnesota, Minneapolis, MN 55414 (United States); Sotiropoulos, Fotis, E-mail: fotis@umn.edu [Saint Anthony Falls Laboratory, University of Minnesota, Minneapolis, MN 55414 (United States); Department of Civil, Environmental and Geo-Engineering, University of Minnesota, Minneapolis, MN 55414 (United States)

    2015-11-01

    We present a new numerical methodology for simulating fluid–structure interaction (FSI) problems involving thin flexible bodies in an incompressible fluid. The FSI algorithm uses the Dirichlet–Neumann partitioning technique. The curvilinear immersed boundary method (CURVIB) is coupled with a rotation-free finite element (FE) model for thin shells enabling the efficient simulation of FSI problems with arbitrarily large deformation. Turbulent flow problems are handled using large-eddy simulation with the dynamic Smagorinsky model in conjunction with a wall model to reconstruct boundary conditions near immersed boundaries. The CURVIB and FE solvers are coupled together on the flexible solid–fluid interfaces where the structural nodal positions, displacements, velocities and loads are calculated and exchanged between the two solvers. Loose and strong coupling FSI schemes are employed enhanced by the Aitken acceleration technique to ensure robust coupling and fast convergence especially for low mass ratio problems. The coupled CURVIB-FE-FSI method is validated by applying it to simulate two FSI problems involving thin flexible structures: 1) vortex-induced vibrations of a cantilever mounted in the wake of a square cylinder at different mass ratios and at low Reynolds number; and 2) the more challenging high Reynolds number problem involving the oscillation of an inverted elastic flag. For both cases the computed results are in excellent agreement with previous numerical simulations and/or experiential measurements. Grid convergence tests/studies are carried out for both the cantilever and inverted flag problems, which show that the CURVIB-FE-FSI method provides their convergence. Finally, the capability of the new methodology in simulations of complex cardiovascular flows is demonstrated by applying it to simulate the FSI of a tri-leaflet, prosthetic heart valve in an anatomic aorta and under physiologic pulsatile conditions.

  10. A numerical approach for simulating fluid structure interaction of flexible thin shells undergoing arbitrarily large deformations in complex domains

    Science.gov (United States)

    Gilmanov, Anvar; Le, Trung Bao; Sotiropoulos, Fotis

    2015-11-01

    We present a new numerical methodology for simulating fluid-structure interaction (FSI) problems involving thin flexible bodies in an incompressible fluid. The FSI algorithm uses the Dirichlet-Neumann partitioning technique. The curvilinear immersed boundary method (CURVIB) is coupled with a rotation-free finite element (FE) model for thin shells enabling the efficient simulation of FSI problems with arbitrarily large deformation. Turbulent flow problems are handled using large-eddy simulation with the dynamic Smagorinsky model in conjunction with a wall model to reconstruct boundary conditions near immersed boundaries. The CURVIB and FE solvers are coupled together on the flexible solid-fluid interfaces where the structural nodal positions, displacements, velocities and loads are calculated and exchanged between the two solvers. Loose and strong coupling FSI schemes are employed enhanced by the Aitken acceleration technique to ensure robust coupling and fast convergence especially for low mass ratio problems. The coupled CURVIB-FE-FSI method is validated by applying it to simulate two FSI problems involving thin flexible structures: 1) vortex-induced vibrations of a cantilever mounted in the wake of a square cylinder at different mass ratios and at low Reynolds number; and 2) the more challenging high Reynolds number problem involving the oscillation of an inverted elastic flag. For both cases the computed results are in excellent agreement with previous numerical simulations and/or experiential measurements. Grid convergence tests/studies are carried out for both the cantilever and inverted flag problems, which show that the CURVIB-FE-FSI method provides their convergence. Finally, the capability of the new methodology in simulations of complex cardiovascular flows is demonstrated by applying it to simulate the FSI of a tri-leaflet, prosthetic heart valve in an anatomic aorta and under physiologic pulsatile conditions.

  11. Tele-operation of the electric power generation and transmission in large complex; Teleoperacao da geracao e transmissao de energia eletrica em complexo de grande porte

    Energy Technology Data Exchange (ETDEWEB)

    Martini, Jose Sidnei Colombo

    1992-07-01

    This work presents the specification and development outstanding aspects of a large supervisory and control power system. The engineering experiment, named SSCH - Hierarchical Supervision and Control System, occurred between 1982 and 1992 at Sao Paulo State and is an industrial automation power system most expressive cases carried out in this decade. More than complex development technical details, important management aspects concerning with large project execution are discussed. The SSCHs special characteristics are its dimension, complexity and realtime network analysis resources, applied to large power systems. (author)

  12. Design of a Binuclear Ni(II) Complex with Large Ising-type Anisotropy and Weak Anti-Ferromagnetic Coupling.

    Science.gov (United States)

    El-Khatib, Fatima; Cahier, Benjamin; López-Jordà, Maurici; Guillot, Régis; Rivière, Eric; Hafez, Hala; Saad, Zeinab; Girerd, Jean-Jacques; Guihéry, Nathalie; Mallah, Talal

    2017-09-05

    The preparation of a binuclear Ni(II) complex with a pentacoordinate environment using a cryptand organic ligand and the imidazolate bridge is reported. The coordination sphere is close to trigonal bipyramidal (tbp) for one Ni(II) and to square pyramidal (spy) for the other. The use of the imidazolate bridge that undergoes π-π stacking with two benzene rings of the chelating ligand induces steric hindrance that stabilizes the pentacoordinate environment. Magnetic measurements together with theoretical studies of the spin states energy levels allow fitting the data and reveal a large Ising-type anisotropy and a weak anti-ferromagnetic exchange coupling between the metal ions. The magnitude and the nature of the magnetic anisotropy and the difference in anisotropy between the two metal ions are rationalized using wave-function-based calculations. We show that a slight distortion of the coordination sphere of Ni(II) from spy to tbp leads to an Ising-type anisotropy. Broken-symmetry density functional calculations rationalize the weak anti-ferromagnetic exchange coupling through the imidazolate bridge.

  13. The Evolution of a Hierarchical Partitioning Algorithm for Large-Scale Scientific Data: Three Steps of Increasing Complexity

    Energy Technology Data Exchange (ETDEWEB)

    Baldwin, C; Eliassi-Rad, T; Abdulla, G; Critchlow, T

    2003-04-16

    As scientific data sets grow exponentially in size, the need for scalable algorithms that heuristically partition the data increases. In this paper, we describe the three-step evolution of a hierarchical partitioning algorithm for large-scale spatio-temporal scientific data sets generated by massive simulations. The first version of our algorithm uses a simple top-down partitioning technique, which divides the data by using a four-way bisection of the spatio-temporal space. The shortcomings of this algorithm lead to the second version of our partitioning algorithm, which uses a bottom-up approach. In this version, a partition hierarchy is constructed by systematically agglomerating the underlying Cartesian grid that is placed on the data. Finally, the third version of our algorithm utilizes the intrinsic topology of the data given in the original scientific problem to build the partition hierarchy in a bottom-up fashion. Specifically, the topology is used to heuristically agglomerate the data at each level of the partition hierarchy. Despite the growing complexity in our algorithms, the third version of our algorithm builds partition hierarchies in less time and is able to build trees for larger size data sets as compared to the previous two versions.

  14. Hierarchically-Porous Carbon Derived from a Large-Scale Iron-based Organometallic Complex for Versatile Energy Storage.

    Science.gov (United States)

    Fan, Chao-Ying; Li, Huan-Huan; Wang, Hai-Feng; Sun, Hai-Zhu; Wu, Xing-Long; Zhang, Jing-Ping

    2016-06-22

    Inspired by the preparation of the hierarchically-porous carbon (HPC) derived from metal organic frameworks (MOFs) for energy storage, in this work, a simple iron-based metal- organic complex (MOC), which was simpler and cheaper compared with the MOF, was selected to achieve versatile energy storage. The intertwined 1 D nanospindles and enriched-oxygen doping of the HPC was obtained after one-step carbonization of the MOC. When employed in lithium-ion batteries, the HPC exhibited reversible capacity of 778 mA h g(-1) after 60 cycles at 50 mA g(-1) . Moreover, the HPC maintained a capacity of 188 mA h g(-1) after 400 cycles at 100 mA g(-1) as the anode material in a sodium-ion battery. In addition, the HPC served as the cathode matrix for evaluation of a lithium-sulfur battery. The general preparation process of the HPC is commercial, which is responsible for the large-scale production for its practical application. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  15. Dosimetric characterization of hypofractionated Gamma Knife radiosurgery of large or complex brain tumors versus linear accelerator-based treatments.

    Science.gov (United States)

    Dong, Peng; Pérez-Andújar, Angélica; Pinnaduwage, Dilini; Braunstein, Steve; Theodosopoulos, Philip; McDermott, Michael; Sneed, Penny; Ma, Lijun

    2016-12-01

    OBJECTIVE Noninvasive Gamma Knife (GK) platforms, such as the relocatable frame and on-board imaging, have enabled hypofractionated GK radiosurgery of large or complex brain lesions. This study aimed to characterize the dosimetric quality of such treatments against linear accelerator-based delivery systems that include the CyberKnife (CK) and volumetric modulated arc therapy (VMAT). METHODS Ten patients treated with VMAT at the authors' institution for large brain tumors (> 3 cm in maximum diameter) were selected for the study. The median prescription dose was 25 Gy (range 20-30 Gy) in 5 fractions. The median planning target volume (PTV) was 9.57 cm(3) (range 1.94-24.81 cm(3)). Treatment planning was performed using Eclipse External Beam Planning V11 for VMAT on the Varian TrueBeam system, Multiplan V4.5 for the CyberKnife VSI System, and Leksell GammaPlan V10.2 for the Gamma Knife Perfexion system. The percentage of the PTV receiving at least the prescription dose was normalized to be identical across all platforms for individual cases. The prescription isodose value for the PTV, conformity index, Paddick gradient index, mean and maximum doses for organs at risk, and normal brain dose at variable isodose volumes ranging from the 5-Gy isodose volume (V5) to the 15-Gy isodose volume (V15) were compared for all of the cases. RESULTS The mean Paddick gradient index was 2.6 ± 0.2, 3.2 ± 0.5, and 4.3 ± 1.0 for GK, CK, and VMAT, respectively (p 0.06). The average prescription isodose values were 52% (range 47%-69%), 60% (range 46%-68%), and 88% (range 70%-94%) for GK, CK, and VMAT, respectively, thus producing significant variations in dose hot spots among the 3 platforms. Furthermore, the mean V5 values for GK and CK were similar (p > 0.79) at 71.9 ± 36.2 cm(3) and 73.3 ± 31.8 cm(3), respectively, both of which were statistically lower (p < 0.01) than the mean V5 value of 124.6 ± 67.1 cm(3) for VMAT. CONCLUSIONS Significantly better near-target normal brain

  16. Predictive Big Data Analytics: A Study of Parkinson's Disease Using Large, Complex, Heterogeneous, Incongruent, Multi-Source and Incomplete Observations.

    Science.gov (United States)

    Dinov, Ivo D; Heavner, Ben; Tang, Ming; Glusman, Gustavo; Chard, Kyle; Darcy, Mike; Madduri, Ravi; Pa, Judy; Spino, Cathie; Kesselman, Carl; Foster, Ian; Deutsch, Eric W; Price, Nathan D; Van Horn, John D; Ames, Joseph; Clark, Kristi; Hood, Leroy; Hampstead, Benjamin M; Dauer, William; Toga, Arthur W

    2016-01-01

    A unique archive of Big Data on Parkinson's Disease is collected, managed and disseminated by the Parkinson's Progression Markers Initiative (PPMI). The integration of such complex and heterogeneous Big Data from multiple sources offers unparalleled opportunities to study the early stages of prevalent neurodegenerative processes, track their progression and quickly identify the efficacies of alternative treatments. Many previous human and animal studies have examined the relationship of Parkinson's disease (PD) risk to trauma, genetics, environment, co-morbidities, or life style. The defining characteristics of Big Data-large size, incongruency, incompleteness, complexity, multiplicity of scales, and heterogeneity of information-generating sources-all pose challenges to the classical techniques for data management, processing, visualization and interpretation. We propose, implement, test and validate complementary model-based and model-free approaches for PD classification and prediction. To explore PD risk using Big Data methodology, we jointly processed complex PPMI imaging, genetics, clinical and demographic data. Collective representation of the multi-source data facilitates the aggregation and harmonization of complex data elements. This enables joint modeling of the complete data, leading to the development of Big Data analytics, predictive synthesis, and statistical validation. Using heterogeneous PPMI data, we developed a comprehensive protocol for end-to-end data characterization, manipulation, processing, cleaning, analysis and validation. Specifically, we (i) introduce methods for rebalancing imbalanced cohorts, (ii) utilize a wide spectrum of classification methods to generate consistent and powerful phenotypic predictions, and (iii) generate reproducible machine-learning based classification that enables the reporting of model parameters and diagnostic forecasting based on new data. We evaluated several complementary model-based predictive approaches

  17. Discussion on Development Mode of Large Railway Hubs in High-speed Rail Era:From Transportation Complex to Urban Complex

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    At present, most of China’s railway hubs are developed to be transportation complexes, with some problems like unsmooth traffic circulation, mixed but disordered functions, separated spaces, etc. In high-speed rail era, high-speed railway hubs should be regarded as the catalyst to promoted urban development. The mode of urban complex should be developed, to closely connect the railway hub and the surrounding area within walking distance, so as people could get to their destinations in the most convenient way. Furthermore, it would strengthen people’s aggregation, thus to bring about larger scale urban development by the successful development of urban complex.

  18. The next generation of target capture technologies - large DNA fragment enrichment and sequencing determines regional genomic variation of high complexity.

    Science.gov (United States)

    Dapprich, Johannes; Ferriola, Deborah; Mackiewicz, Kate; Clark, Peter M; Rappaport, Eric; D'Arcy, Monica; Sasson, Ariella; Gai, Xiaowu; Schug, Jonathan; Kaestner, Klaus H; Monos, Dimitri

    2016-07-09

    The ability to capture and sequence large contiguous DNA fragments represents a significant advancement towards the comprehensive characterization of complex genomic regions. While emerging sequencing platforms are capable of producing several kilobases-long reads, the fragment sizes generated by current DNA target enrichment technologies remain a limiting factor, producing DNA fragments generally shorter than 1 kbp. The DNA enrichment methodology described herein, Region-Specific Extraction (RSE), produces DNA segments in excess of 20 kbp in length. Coupling this enrichment method to appropriate sequencing platforms will significantly enhance the ability to generate complete and accurate sequence characterization of any genomic region without the need for reference-based assembly. RSE is a long-range DNA target capture methodology that relies on the specific hybridization of short (20-25 base) oligonucleotide primers to selected sequence motifs within the DNA target region. These capture primers are then enzymatically extended on the 3'-end, incorporating biotinylated nucleotides into the DNA. Streptavidin-coated beads are subsequently used to pull-down the original, long DNA template molecules via the newly synthesized, biotinylated DNA that is bound to them. We demonstrate the accuracy, simplicity and utility of the RSE method by capturing and sequencing a 4 Mbp stretch of the major histocompatibility complex (MHC). Our results show an average depth of coverage of 164X for the entire MHC. This depth of coverage contributes significantly to a 99.94 % total coverage of the targeted region and to an accuracy that is over 99.99 %. RSE represents a cost-effective target enrichment method capable of producing sequencing templates in excess of 20 kbp in length. The utility of our method has been proven to generate superior coverage across the MHC as compared to other commercially available methodologies, with the added advantage of producing longer sequencing

  19. Provenance of a large Lower Cretaceous turbidite submarine fan complex on the active Laurasian margin: Central Pontides, northern Turkey

    Science.gov (United States)

    Akdoğan, Remziye; Okay, Aral I.; Sunal, Gürsel; Tari, Gabor; Meinhold, Guido; Kylander-Clark, Andrew R. C.

    2017-02-01

    The Pontides formed the southern active margin of Laurasia during the Mesozoic. They became separated from mainland Laurasia during the Late Cretaceous, with the opening of the Black Sea as an oceanic back-arc basin. During the Early Cretaceous, a large submarine turbidite fan complex developed in the Central Pontides. The turbidites cover an area of 400 km by 90 km with a thickness of more than 2 km. We have investigated the provenance of these turbidites-the Çağlayan Formation-using paleocurrent measurements, U-Pb detrital zircon ages, REE abundances of dated zircons and geochemistry of detrital rutile grains. 1924 paleocurrent measurements from 96 outcrop stations indicate flow direction from northwest to southeast in the eastern part of the Çağlayan Basin and from north-northeast to west-southwest in the western part. 1194 detrital zircon ages from 13 Lower Cretaceous sandstone samples show different patterns in the eastern, central and western parts of the basin. The majority of the U-Pb detrital zircon ages in the eastern part of the basin are Archean and Paleoproterozoic (61% of all zircon ages, 337 grains); rocks of these ages are absent in the Pontides and present in the Ukrainian Shield, which indicates a source north of the Black Sea. In the western part of the basin the majority of the zircons are Carboniferous and Neoproterozoic (68%, 246 grains) implying more local sources within the Pontides. The detrital zircons from the central part show an age spectrum as mixture of zircons from western and eastern parts. Significantly, Jurassic and Early Cretaceous zircons make up less than 2% of the total zircon population, which implies lack of a coeval magmatic arc in the region. This is compatible with the absence of the Lower Cretaceous granites in the Pontides. Thus, although the Çağlayan Basin occupied a fore-arc position above the subduction zone, the arc was missing, probably due to flat subduction, and the basin was largely fed from the Ukrainian

  20. Novel large heteropolymetalate complexes formed from Ni(II) and cryptate [As4W40O140]28-

    Institute of Scientific and Technical Information of China (English)

    XUE; Ganglin; (

    2003-01-01

    [1]Rhule, J. T., Hill, C. L., Tudd, D. A. et al., Polyoxometalates in medicine, Chem. Rev., 1998, 98: 327-357.[2]Pope, M. T., Müller, A., Polyoxometellates: from Platonic Solids to Antiretro-Viral Activity, Kluver: Dordrecht, 1994, 245-371.[3]Ouahab, L., Organic/inorganic supramolecular assemblies and synergy between physical properties, Chem. Mater., 1997, 9: 1909-1926.[4]Baker, L. C. W., Glick, D. C., Present general status of understanding of heteropoly electrolytes and a tracing of some major highlights in the history of their elucidation, Chem. Rev., 1998, 98: 3-49.[5]Hill, C. L., Prosser-Mclartha, C. M., Homogeneous catalysis by transition metal oxygen anion clusters, Coordination Chemistry Reviews, 1995, 143: 407-455.[6]Liu Jingfu, Guo Jun, Zhao Beng et al., Synthesis and characterization of novel heteropolytungstoarsenate containing lanthanum [LaAs4W40O140]25- and its derivatives [LaAs4W40O140M2]n-[J], Transition Met. Chem., 1993, 18: 205-208.[7]Wassermann, K., Pope, M. T., Large cluster formation though multiple substitution with lanthanide cations (La, Ce, Nd, Sm, Eu, and Gd) of the polyoxoanion [(B-a-AsO3W9O30)4(WO2)4]28-: Synthesis and structural characterization, Inorg. Chem., 2001, 40: 2763-2768.[8]Xue Ganglin, A new large heteropolyanion [As4W40O140Ce(H2O)5]25-, Acta Chimica Sinica (in Chinese), 2001, 59: 1519-1521.[9]Robert, F., Leyrie, M., Herve, G. et al., Crystal structure of ammonium dicobalto (II)-40-tungstotetraarsenate (III): Allosteric effects in the ligand, lnorg. Chem., 1980, 19: 1746-1752.[10]Hur, N. H., Klemperer, W. G., Wang, R. C. et al., Sodium tetracontatungstotetraarsenate (III), Na27[NaAs4W40O140]@ 60H2O, Inorganic Synthesis, 1990, 27: 118-119.[11]Xu Jiqing, Wang Renzhang, Guo Chunxiao et al., Hydrothermal synthesis, structure and quantum chemistry of transition metal complex supported by metal-oxo cluster [{Ni(phen)2}2 (ξ-Mo8O26)], Science in China, Series B, 2001, 44(2): 137-146.[12

  1. Three-dimensional packaging of very large scale integrated optics (VLSIO) for high-complexity optical systems

    Science.gov (United States)

    West, Lawrence C.; Roberts, Charles W.; Piscani, Emil C.; Dubey, Madan; Jones, Kenneth A.; McLane, George F.

    1996-03-01

    Optics has the fundamental capability of dramatically improving computer performance via the reduction of capacitance for intrinsic high bandwidth communications and low power usage. Yet optical devices have not displaced silicon VLSI in any measure to date. The reason is clear. When placed into systems, the optical devices have not had significantly greater performance in equally complex information processing circuits and similarly low manufacturing cost. An approach demonstrated here uses the same system integration techniques that have been successful for silicon electronics, only applied to optics. Essential for creation of very large scale integrated optics (VLSIO), with over 50,000 high speed logic gates per square centimeter, is a new class of ultra high confinement (UHC) waveguides. These waveguides are created with high index difference (as high as 4.0 to 1.0) between guide and cladding. The waveguides have been demonstrated with infrared cross sections less than 5% of a square free space wavelength. These waveguides can be manufactured today only in the mid-infrared, but the concepts should scale to the near-infrared as lithography improves. Waveguide corners have been designed and demonstrated with a bend radius of less than one free space wavelength. Resonators have been designed which have over 100 times smaller volume than VCSELs, yet efficiently inter-connected laterally in high densities. A connector to the UHC waveguides has been developed and demonstrated using diffractive optical element arrays on the back side of the substrate. The coupler arrays can allow up to 10,000 Gaussian beam connections per square centimeter. This connectivity also has advantages for low cost three dimensional packaging for reduced cost and thermal dissipation. Experimental results on the above concepts and components are presented.

  2. SU-E-T-76: A Software System to Monitor VMAT Plan Complexity in a Large Radiotherapy Centre

    Energy Technology Data Exchange (ETDEWEB)

    Arumugam, S; Xing, A [Liverpool and Macarthur Cancer Therapy Centres, Sydney, NSW (Australia); Ingham Institute, Sydney, NSW (Australia); Vial, P [Liverpool and Macarthur Cancer Therapy Centres, Sydney, NSW (Australia); Ingham Institute, Sydney, NSW (Australia); Institute of Medical Physics, School of Physics, University of Sydney, Sydney, NSW (Australia); Thwaites, D [Institute of Medical Physics, School of Physics, University of Sydney, Sydney, NSW (Australia); Holloway, L [Liverpool and Macarthur Cancer Therapy Centres, Sydney, NSW (Australia); Ingham Institute, Sydney, NSW (Australia); Institute of Medical Physics, School of Physics, University of Sydney, Sydney, NSW (Australia); Centre for Medical Radiation Physics, University of Wollongong, Wollongong, NSW (Australia)

    2015-06-15

    Purpose: To develop a system that analyses and reports the complexity of Volumetric Modulated Arc Therapy (VMAT) plans to aid in the decision making for streamlining patient specific dosimetric quality assurance (QA) tests. Methods: A software system, Delcheck, was developed in-house to calculate VMAT plan and delivery complexity using the treatment delivery file. Delcheck has the functionality to calculate multiple plan complexity metrics including the Li-Xing Modulation Index (LI-MI), multiplicative combination of Leaf Travel and Modulation Complexity Score (LTMCSv), Monitor Units per prescribed dose (MU/D) and the delivery complexity index (MIt) that incorporates the modulation of dose rate, leaf speed and gantry speed. Delcheck includes database functionality to store and compare plan metrics for a specified treatment site. The overall plan and delivery complexity is assessed based on the 95% conformance limit of the complexity metrics as Similar, More or Less complex. The functionality of the software was tested using 42 prostate conventional, 10 prostate SBRT and 15 prostate bed VMAT plans generated for an Elekta linear accelerator. Results: The mean(σ) of LI-MI for conventional, SBRT and prostate bed plans were 1690(486), 3215.4(1294) and 3258(982) respectively. The LTMCSv of the studied categories were 0.334(0.05), 0.325(0.07) and 0.3112(0.09). The MU/D of the studied categories were 2.4(0.4), 2.7(0.7) and 2.5(0.5). The MIt of the studied categories were 21.6(3.4), 18.2(3.0) and 35.9(6.6). The values of the complexity metrics show that LI-MI appeared to resolve the plan complexity better than LTMCSv and MU/D. The MIt value increased as the delivery complexity increased. Conclusion: The developed software was shown to be working as expected. In studied treatment categories Prostate bed plans are more complex in both plan and delivery and SBRT is more complex in plan and less complex in delivery as demonstrated by LI-MI and MIt. This project was funded

  3. How do you assign persistent identifiers to extracts from large, complex, dynamic data sets that underpin scholarly publications?

    Science.gov (United States)

    Wyborn, Lesley; Car, Nicholas; Evans, Benjamin; Klump, Jens

    2016-04-01

    Persistent identifiers in the form of a Digital Object Identifier (DOI) are becoming more mainstream, assigned at both the collection and dataset level. For static datasets, this is a relatively straight-forward matter. However, many new data collections are dynamic, with new data being appended, models and derivative products being revised with new data, or the data itself revised as processing methods are improved. Further, because data collections are becoming accessible as services, researchers can log in and dynamically create user-defined subsets for specific research projects: they also can easily mix and match data from multiple collections, each of which can have a complex history. Inevitably extracts from such dynamic data sets underpin scholarly publications, and this presents new challenges. The National Computational Infrastructure (NCI) has been experiencing and making progress towards addressing these issues. The NCI is large node of the Research Data Services initiative (RDS) of the Australian Government's research infrastructure, which currently makes available over 10 PBytes of priority research collections, ranging from geosciences, geophysics, environment, and climate, through to astronomy, bioinformatics, and social sciences. Data are replicated to, or are produced at, NCI and then processed there to higher-level data products or directly analysed. Individual datasets range from multi-petabyte computational models and large volume raster arrays, down to gigabyte size, ultra-high resolution datasets. To facilitate access, maximise reuse and enable integration across the disciplines, datasets have been organized on a platform called the National Environmental Research Data Interoperability Platform (NERDIP). Combined, the NERDIP data collections form a rich and diverse asset for researchers: their co-location and standardization optimises the value of existing data, and forms a new resource to underpin data-intensive Science. New publication

  4. Method of calculation and construction of arrangement sketchy of stone-working machine for the processing of geometrically-complex surfaces of wares of large gabarit

    OpenAIRE

    Чемоданов, Петро Арисович

    2016-01-01

    In the article the method of calculation of basic knots and arrangement sketchy of stone-working gantry milling mapping machine is offered with curvilinear working motion of light cart for the processing of geometrically-complex surfaces on the stoning purveyance of large gabarit.

  5. Radiation hybrid maps of D-genome of Aegilops tauschii and their application in sequence assembly of large and complex plant genomes

    Science.gov (United States)

    The large and complex genome of bread wheat (Triticum aestivum L., ~17 Gb) requires high-resolution genome maps saturated with ordered markers to assist in anchoring and orienting BAC contigs/ sequence scaffolds for whole genome sequence assembly. Radiation hybrid (RH) mapping has proven to be an e...

  6. NICOTINAMIDE IN COMPLEX TREATMENT OF LARGE-PLAQUE PARAPSORIASIS AND EARLY STAGES OF MALIGNANT T-CELL SKIN LYMPHOMAS

    Directory of Open Access Journals (Sweden)

    I. V. Khamaganova

    2014-01-01

    Full Text Available Aim: To assess clinical efficacy of nicotinamide in 2 the treatment of patients with early stages of malignant T-cell skin lymphomas and large-plaque parapsoriasis. Materials and methods: 12 patients with erythematous stage of mycosis fungoides and 14 patients with large-plaque parapsoriasis were treated by nicotinamide 15 mg twice daily during 2 weeks. Treatment cycles were repeated 4–5 times per year; topical therapy was also administrated. Results: Nicotinamide demonstrated high therapeutic effect and good tolerability in patients with early stage of mycosis fungoides and large-plaque parapsoriasis. Stable remission was achieved in 1  woman with malignant T-cell lymphoma and 12  patients with large-plaque parapsoriasis; significant clinical improvement was shown in 8 and 12 patients, respectively. Conclusion: Thus, nicotinamide is recommended for comprehensive treatment of large-plaque parapsoriasis and early stages of mycosis fungoides.

  7. Large-scale remodeling of a repressed exon ribonucleoprotein to an exon definition complex active for splicing.

    Science.gov (United States)

    Wongpalee, Somsakul Pop; Vashisht, Ajay; Sharma, Shalini; Chui, Darryl; Wohlschlegel, James A; Black, Douglas L

    2016-11-24

    Polypyrimidine-tract binding protein PTBP1 can repress splicing during the exon definition phase of spliceosome assembly, but the assembly steps leading to an exon definition complex (EDC) and how PTBP1 might modulate them are not clear. We found that PTBP1 binding in the flanking introns allowed normal U2AF and U1 snRNP binding to the target exon splice sites but blocked U2 snRNP assembly in HeLa nuclear extract. Characterizing a purified PTBP1-repressed complex, as well as an active early complex and the final EDC by SILAC-MS, we identified extensive PTBP1-modulated changes in exon RNP composition. The active early complex formed in the absence of PTBP1 proceeded to assemble an EDC with the eviction of hnRNP proteins, the late recruitment of SR proteins, and binding of the U2 snRNP. These results demonstrate that during early stages of splicing, exon RNP complexes are highly dynamic with many proteins failing to bind during PTBP1 arrest.

  8. A large-scale analysis of tissue-specific pathology and gene expression of human disease genes and complexes

    DEFF Research Database (Denmark)

    Hansen, Kasper Lage; Hansen, Niclas Tue; Karlberg, Erik, Olof, Linnart

    2008-01-01

    Heritable diseases are caused by germ-line mutations that, despite tissuewide presence, often lead to tissue-specific pathology. Here, we make a systematic analysis of the link between tissue-specific gene expression and pathological manifestations in many human diseases and cancers. Diseases were...... to be overexpressed in the normal tissues where defects cause pathology. In contrast, cancer genes and complexes were not overexpressed in the tissues from which the tumors emanate. We specifically identified a complex involved in XY sex reversal that is testis-specific and down-regulated in ovaries. We also...... identified complexes in Parkinson disease, cardiomyopathies, and muscular dystrophy syndromes that are similarly tissue specific. Our method represents a conceptual scaffold for organism-spanning analyses and reveals an extensive list of tissue-specific draft molecular pathways, both known and unexpected...

  9. Technology for Obtaining Large Size Complex Oxide Crystals for Experiments on Muon-Electron Conversion Registration in High Energy Physics

    Directory of Open Access Journals (Sweden)

    Gerasymov, Ya.

    2014-11-01

    Full Text Available Technological approaches for qualitative large size scintillation crystals growing based on rare-earth silicates are proposed. A method of iridium crucibles charging using eutectic phase instead of a oxyorthosilicate was developed.

  10. Rational serendipity: "undirected" synthesis of a large {MnCu} complex from pre-formed Mn(II) building blocks.

    Science.gov (United States)

    Frost, Jamie M; Kettles, Fraser J; Wilson, Claire; Murrie, Mark

    2016-11-15

    Use of an aminopolyalcohol-based Mn(II) complex in solvothermal Cu(II) chemistry leads to a rare example of a high nuclearity heterometallic {MnCu} system, in which four Cu(II)(H1Edte) units trap an inner {MnCu(II)} oxide core.

  11. Calculation of lipophilicity of a large, diverse dataset of anticancer platinum complexes and the relation to cellular uptake.

    Science.gov (United States)

    Oldfield, Steven P; Hall, Matthew D; Platts, James A

    2007-10-18

    A quantitative structure--property relationship (QPSR) for the octanol--water partition of platinum complexes was constructed using molecular descriptors derived from density functional (DFT) calculations. A dataset of partition data for 64 complexes, consisting of 43 square-planar platinum(II) and 21 octahedral platinum(IV) complexes, was drawn from literature sources. Not only does this dataset include considerable structural diversity of complexes considered but also a variety of techniques for the measurement of partition coefficients. These data were modeled using descriptors drawn from electrostatic potentials and hardness/softness indices projected onto molecular surfaces. This required initial descriptor selection using a genetic algorithm approach, followed by partial least-squares regression against log Po/w data. In this way, a statistically robust model was constructed, with errors of similar size to the variation in log Po/w from multiple experimental measurements. Implications of lipophilicity for cellular accumulation of Pt-based drugs, and hence for design of new drugs, are discussed, as is the uptake of metabolites of cisplatin.

  12. Hydration Differences Explain the Large Variations in the Complexation Thermodynamics of Modified γ-Cyclodextrins with Bile Salts

    DEFF Research Database (Denmark)

    Køhler, Jonatan; Schönbeck, Jens Christian Sidney; Westh, Peter;

    2016-01-01

    The structure and thermodynamics of inclusion complexes of seven different γ-cyclodextrins (γCDs) and three biologically relevant bile salts (BS) were investigated in the present study. Natural γCD and six modified γCDs [two methyl-γCDs, one sulfobutyl ether-γCD (SBEγCD), and three 2-hydroxypropyl...... to those with natural γCD; i.e., the modifications of the γCD had limited structural impact on the formation of complexes. Isothermal titration calorimetry was carried out over in the temperature interval 5–55 °C to enable the calculation of the stability constant (K) and the thermodynamic parameters...... enthalpy (ΔH°), entropy (ΔS°), and heat capacity (ΔCp°). The stability constants decreased with an increased degree of substitution (DS), with methyl substituents having a lower effect on the stability constant than the sulfobutyl ether and hydroxypropyl substituents on the stability constants. Enthalpy...

  13. Photoinduced cleavage by a rhodium complex at G.U mismatches and exposed guanines in large and small RNAs.

    Science.gov (United States)

    Chow, Christine S; Cunningham, Philip R; Lee, KangSeok; Meroueh, May; SantaLucia, John; Varma, Shikha

    2002-09-01

    Photoinduced cleavage reactions by the rhodium complex tris(4,7-diphenyl-1,10-phenanthroline)rhodium(III) [Rh(DIP)(3)(3+)] with three RNA hairpins, r(GGGGU UCGCUC CACCA) (16 nucleotide, tetraloop(Ala2)), r(GGGGCUAUAGCUCUAGCUC CACCA) (24 nucleotide, microhelix(Ala)), and r(GGCGGUUAGAUAUCGCC) (17 nucleotide, 790 loop), and full-length (1542 nucleotide) 16S rRNA from Escherichia coli were investigated. The cleavage reactions were monitored by gel electrophoresis and the sites of cleavage by Rh(DIP)(3)(3+) were determined by comparisons with chemical or enzymatic sequencing reactions. In general, RNA backbone scission by the metal complex was induced at G.U mismatches and at exposed G residues. The cleavage activity was observed on the three small RNA hairpins as well as on the isolated 1542-nucleotide ribosomal RNA.

  14. Large time behavior of solutions for critical and subcritical complex Ginzburg-Landau equations in H1

    Institute of Scientific and Technical Information of China (English)

    王保祥

    2003-01-01

    Considering the Cauchy problem for the critical complex Ginzburg-Landau equation in H1(Rn), weshall show the asymptotic behavior for its solutions in C(0, ∞; H1 (Rn)) ∩ L2(0, ∞; H1,2n/(n-2)(Rn )), n≥ 3.Analogous results also hold in the case that the nonlinearity has the subcritical power in H1(Rn), n≥ 1.

  15. Increasing the options for management of large and complex chronic wounds with a scalable, closed-system dressing for maggot therapy.

    Science.gov (United States)

    Felder, John M; Hechenbleikner, Elizabeth; Jordan, Marion; Jeng, James

    2012-01-01

    As reconstructive specialists, burn surgeons are often involved in managing large wounds of various etiologies. Such wounds can pose a management challenge, especially if they are chronic or occur in the setting of critical illness or multiple medical comorbidities. Medical maggots are an effective, selective, and low-risk method for wound debridement. However, their use in large and geometrically complex wounds is limited by the lack of scalability in currently available dressings, which are appropriate for smaller wounds but become cumbersome and ineffective in larger ones. This report describes a novel dressing designed for application of maggot debridement therapy in large and complex wounds. The authors then discuss how use of this dressing may create new management strategies for such wounds by allowing maggots to mechanically debride big, infected wounds. They describe the construction of a maggot containment dressing based on modified components from a negative pressure wound therapy system and provide a case report highlighting its successful clinical use in a large contaminated chronic wound resulting from Fournier's gangrene. In the case described, the novel dressing provided scalability, containment of maggots, control of secretions, and ease of use. The dressing created an environment suitable for maggot survival and allowed effective debridement of a heavily contaminated groin wound. The novel dressing described is shown to function appropriately, allowing controlled use of maggots for effective debridement of large, irregular wounds. Facilitating the use of maggots in such wounds may broaden the algorithm for their management.

  16. Task Effects on Linguistic Complexity and Accuracy: A Large-Scale Learner Corpus Analysis Employing Natural Language Processing Techniques

    Science.gov (United States)

    Alexopoulou, Theodora; Michel, Marije; Murakami, Akira; Meurers, Detmar

    2017-01-01

    Large-scale learner corpora collected from online language learning platforms, such as the EF-Cambridge Open Language Database (EFCAMDAT), provide opportunities to analyze learner data at an unprecedented scale. However, interpreting the learner language in such corpora requires a precise understanding of tasks: How does the prompt and input of a…

  17. Large-Eddy Simulations of Atmospheric Flows Over Complex Terrain Using the Immersed-Boundary Method in the Weather Research and Forecasting Model

    Science.gov (United States)

    Ma, Yulong; Liu, Heping

    2017-07-01

    Atmospheric flow over complex terrain, particularly recirculation flows, greatly influences wind-turbine siting, forest-fire behaviour, and trace-gas and pollutant dispersion. However, there is a large uncertainty in the simulation of flow over complex topography, which is attributable to the type of turbulence model, the subgrid-scale (SGS) turbulence parametrization, terrain-following coordinates, and numerical errors in finite-difference methods. Here, we upgrade the large-eddy simulation module within the Weather Research and Forecasting model by incorporating the immersed-boundary method into the module to improve simulations of the flow and recirculation over complex terrain. Simulations over the Bolund Hill indicate improved mean absolute speed-up errors with respect to previous studies, as well an improved simulation of the recirculation zone behind the escarpment of the hill. With regard to the SGS parametrization, the Lagrangian-averaged scale-dependent Smagorinsky model performs better than the classic Smagorinsky model in reproducing both velocity and turbulent kinetic energy. A finer grid resolution also improves the strength of the recirculation in flow simulations, with a higher horizontal grid resolution improving simulations just behind the escarpment, and a higher vertical grid resolution improving results on the lee side of the hill. Our modelling approach has broad applications for the simulation of atmospheric flows over complex topography.

  18. On the topologic structure of economic complex networks: Empirical evidence from large scale payment network of Estonia

    CERN Document Server

    de la Torre, Stephanie Rendón; Kitt, Robert; Engelbrecht, Jüri

    2016-01-01

    This paper presents the first topological analysis of the economic structure of an entire country based on payments data obtained from Swedbank. This data set is exclusive in its kind because around 80% of Estonia's bank transactions are done through Swedbank, hence, the economic structure of the country can be reconstructed. Scale-free networks are commonly observed in a wide array of different contexts such as nature and society. In this paper, the nodes are comprised by customers of the bank (legal entities) and the links are established by payments between these nodes. We study the scaling-free and structural properties of this network. We also describe its topology, components and behaviors. We show that this network shares typical structural characteristics known in other complex networks: degree distributions follow a power law, low clustering coefficient and low average shortest path length. We identify the key nodes of the network and perform simulations of resiliency against random and targeted atta...

  19. Genomic exploration and molecular marker development in a large and complex conifer genome using RADseq and mRNAseq.

    Science.gov (United States)

    Karam, M-J; Lefèvre, F; Dagher-Kharrat, M Bou; Pinosio, S; Vendramin, G G

    2015-05-01

    We combined restriction site associated DNA sequencing (RADseq) using a hypomethylation-sensitive enzyme and messenger RNA sequencing (mRNAseq) to develop molecular markers for the 16 gigabase genome of Cedrus atlantica, a conifer tree species. With each method, Illumina(®) reads from one individual were used to generate de novo assemblies. SNPs from the RADseq data set were detected in a panel of one single individual and three pools of three individuals each. We developed a flexible script to estimate the ascertainment bias in SNP detection considering the pooling and sampling effects on the probability of not detecting an existing polymorphism. Gene Ontology (GO) and transposable element (TE) search analyses were applied to both data sets. The RADseq and the mRNAseq assemblies represented 0.1% and 0.6% of the genome, respectively. Genome complexity reduction resulted in 17% of the RADseq contigs potentially coding for proteins. This rate was doubled in the mRNAseq data set, suggesting that RADseq also explores noncoding low-repeat regions. The two methods gave very similar GO-slim profiles. As expected, the two assemblies were poor in TE-like sequences (<4% of contigs length). We identified 17,348 single nucleotide polymorphisms (SNPs) in the RADseq data set and 5,714 simple sequence repeats (SSRs) in the transcriptome. A subset of 282 SNPs was validated using the Fluidigm genotyping technology, giving a conversion rate of 50.4%, falling within the expected range for conifers. Increasing sample size had the greatest effect for ascertainment bias reduction. These results validated the utility of the RADseq approach for highly complex genomes such as conifers.

  20. Large-scale magmatic layering in the Main Zone of the Bushveld Complex and episodic downward magma infiltration

    Science.gov (United States)

    Hayes, Ben; Ashwal, Lewis D.; Webb, Susan J.; Bybee, Grant M.

    2017-03-01

    The Bellevue drillcore intersects 3 km of Main and Upper Zone cumulates in the Northern Limb of the Bushveld Complex. Main Zone cumulates are predominately gabbronorites, with localized layers of pyroxenite and anorthosite. Some previous workers, using bulk rock major, trace and isotopic compositions, have suggested that the Main Zone crystallized predominantly from a single pulse of magma. However, density measurements throughout the Bellevue drillcore reveal intervals that show up-section increases in bulk rock density, which are difficult to explain by crystallization from a single batch of magma. Wavelet analysis of the density data suggests that these intervals occur on length-scales of 40 to 170 m, thus defining a scale of layering not previously described in the Bushveld Complex. Upward increases in density in the Main Zone correspond to upward increases in modal pyroxene, producing intervals that grade from a basal anorthosite (with 5% pyroxene) to gabbronorite (with 30-40% pyroxene). We examined the textures and mineral compositions of a 40 m thick interval showing upwardly increasing density to establish how this type of layering formed. Plagioclase generally forms euhedral laths, while orthopyroxene is interstitial in texture and commonly envelops finer-grained and embayed plagioclase grains. Minor interstitial clinopyroxene was the final phase to crystallize from the magma. Plagioclase compositions show negligible change up-section (average An62), with local reverse zoning at the rims of cumulus laths (average increase of 2 mol%). In contrast, interstitial orthopyroxene compositions become more primitive up-section, from Mg# 57 to Mg# 63. Clinopyroxene similarly shows an up-section increase in Mg#. Pyroxene compositions record the primary magmatic signature of the melt at the time of crystallization and are not an artefact of the trapped liquid shift effect. Combined, the textures and decoupled mineral compositions indicate that the upward density

  1. Using family-based imputation in genome-wide association studies with large complex pedigrees: the Framingham Heart Study.

    Directory of Open Access Journals (Sweden)

    Ming-Huei Chen

    Full Text Available Imputation has been widely used in genome-wide association studies (GWAS to infer genotypes of un-genotyped variants based on the linkage disequilibrium in external reference panels such as the HapMap and 1000 Genomes. However, imputation has only rarely been performed based on family relationships to infer genotypes of un-genotyped individuals. Using 8998 Framingham Heart Study (FHS participants genotyped with Affymetrix 550K SNPs, we imputed genotypes of same set of SNPs for additional 3121 participants, most of whom were never genotyped due to lack of DNA sample. Prior to imputation, 122 pedigrees were too large to be handled by the imputation software Merlin. Therefore, we developed a novel pedigree splitting algorithm that can maximize the number of genotyped relatives for imputing each un-genotyped individual, while keeping new sub-pedigrees under a pre-specified size. In GWAS of four phenotypes available in FHS (Alzheimer disease, circulating levels of fibrinogen, high-density lipoprotein cholesterol, and uric acid, we compared results using genotyped individuals only with results using both genotyped and imputed individuals. We studied the impact of applying different imputation quality filtering thresholds on the association results and did not found a universal threshold that always resulted in a more significant p-value for previously identified loci. However most of these loci had a lower p-value when we only included imputed genotypes with with ≥60% SNP- and ≥50% person-specific imputation certainty. In summary, we developed a novel algorithm for splitting large pedigrees for imputation and found a plausible imputation quality filtering threshold based on FHS. Further examination may be required to generalize this threshold to other studies.

  2. Large-scale structure of RecA protein from Deinococcus radiodurance and its complexes in solution

    Science.gov (United States)

    Karelov, D. V.; Lebedev, D. V.; Suslov, A. V.; Shalguev, V. I.; Kuklin, A. I.; Islamov, A. Kh; Lauter, H.; Lanzov, V. A.; Isaev-Ivanov, V. V.

    2008-03-01

    Different conformational states of the filaments formed by RecA protein from a radiation resistant strain Deinococcus radiodurance (RecADr) in solution were investigated using small angle neutron scattering. Scattering by the protein self-polymer was consistent with a long helix model, with the pitch of the helix being lower than that in the crystal structure. Compared to those of RecA proteins from Escherichia coli and Pseudomonas aeruginosa, helical filaments of RecA from D. radiodurance exhibited a lower helical pitch and lower stability at low Mg2+ concentrations or under conditions of elevated ionic strength in the absence of ATP (adenosine triphosphate). Formation of an active filament upon binding of ATPγS and either single- or double-stranded DNA brought about a significant increase in the helix pitch and a moderate decrease in the cross-sectional gyration radius, but resulted in little change in the number of monomers per helix turn. The helix pitch value of the RecADr presynaptic complex was conservative and close to that found for other RecA proteins and their analogs.

  3. BCL::Fold--de novo prediction of complex and large protein topologies by assembly of secondary structure elements.

    Directory of Open Access Journals (Sweden)

    Mert Karakaş

    Full Text Available Computational de novo protein structure prediction is limited to small proteins of simple topology. The present work explores an approach to extend beyond the current limitations through assembling protein topologies from idealized α-helices and β-strands. The algorithm performs a Monte Carlo Metropolis simulated annealing folding simulation. It optimizes a knowledge-based potential that analyzes radius of gyration, β-strand pairing, secondary structure element (SSE packing, amino acid pair distance, amino acid environment, contact order, secondary structure prediction agreement and loop closure. Discontinuation of the protein chain favors sampling of non-local contacts and thereby creation of complex protein topologies. The folding simulation is accelerated through exclusion of flexible loop regions further reducing the size of the conformational search space. The algorithm is benchmarked on 66 proteins with lengths between 83 and 293 amino acids. For 61 out of these proteins, the best SSE-only models obtained have an RMSD100 below 8.0 Å and recover more than 20% of the native contacts. The algorithm assembles protein topologies with up to 215 residues and a relative contact order of 0.46. The method is tailored to be used in conjunction with low-resolution or sparse experimental data sets which often provide restraints for regions of defined secondary structure.

  4. DNA barcoding the Lepidoptera inventory of a large complex tropical conserved wildland, Area de Conservacion Guanacaste, northwestern Costa Rica.

    Science.gov (United States)

    Janzen, Daniel H; Hallwachs, Winnie

    2016-09-01

    The 37-year ongoing inventory of the estimated 15 000 species of Lepidoptera living in the 125 000 terrestrial hectares of Area de Conservacion Guanacaste, northwestern Costa Rica, has DNA barcode documented 11 000+ species, and the simultaneous inventory of at least 6000+ species of wild-caught caterpillars, plus 2700+ species of parasitoids. The inventory began with Victorian methodologies and species-level perceptions, but it was transformed in 2004 by the full application of DNA barcoding for specimen identification and species discovery. This tropical inventory of an extraordinarily species-rich and complex multidimensional trophic web has relied upon the sequencing services provided by the Canadian Centre for DNA Barcoding, and the informatics support from BOLD, the Barcode of Life Data Systems, major tools developed by the Centre for Biodiversity Genomics at the Biodiversity Institute of Ontario, and available to all through couriers and the internet. As biodiversity information flows from these many thousands of undescribed and often look-alike species through their transformations to usable product, we see that DNA barcoding, firmly married to our centuries-old morphology-, ecology-, microgeography-, and behavior-based ways of taxonomizing the wild world, has made possible what was impossible before 2004. We can now work with all the species that we find, as recognizable species-level units of biology. In this essay, we touch on some of the details of the mechanics of actually using DNA barcoding in an inventory.

  5. On the topologic structure of economic complex networks: Empirical evidence from large scale payment network of Estonia

    Science.gov (United States)

    Rendón de la Torre, Stephanie; Kalda, Jaan; Kitt, Robert; Engelbrecht, Jüri

    2016-09-01

    This paper presents the first topological analysis of the economic structure of an entire country based on payments data obtained from Swedbank. This data set is exclusive in its kind because around 80% of Estonia's bank transactions are done through Swedbank, hence, the economic structure of the country can be reconstructed. Scale-free networks are commonly observed in a wide array of different contexts such as nature and society. In this paper, the nodes are comprised by customers of the bank (legal entities) and the links are established by payments between these nodes. We study the scaling-free and structural properties of this network. We also describe its topology, components and behaviors. We show that this network shares typical structural characteristics known in other complex networks: degree distributions follow a power law, low clustering coefficient and low average shortest path length. We identify the key nodes of the network and perform simulations of resiliency against random and targeted attacks of the nodes with two different approaches. With this, we find that by identifying and studying the links between the nodes is possible to perform vulnerability analysis of the Estonian economy with respect to economic shocks.

  6. Discs large 1 (Dlg1) scaffolding protein participates with clathrin and adaptator protein complex 1 (AP-1) in forming Weibel-Palade bodies of endothelial cells.

    Science.gov (United States)

    Philippe, Monique; Léger, Thibaut; Desvaux, Raphaëlle; Walch, Laurence

    2013-05-03

    Weibel-Palade bodies (WPBs) are specific cigar-shaped granules that store von Willebrand factor (VWF) for its regulated secretion by endothelial cells. The first steps of the formation of these granules at the trans-Golgi network specifically require VWF aggregation and an external scaffolding complex that contains the adaptator protein complex 1 (AP-1) and clathrin. Discs large 1 (Dlg1) is generally considered to be a modular scaffolding protein implicated in the control of cell polarity in a large variety of cells by specific recruiting of receptors, channels, or signaling proteins to specialized zones of the plasma membrane. We propose here that in endothelial cells, Dlg1, in a complex with AP-1 and clathrin, participates in the biogenesis of WPBs. Supporting data show that Dlg1 colocalizes with microtubules, intermediate filaments, and Golgi markers. Tandem mass spectrometry experiments led to the identification of clathrin as an Dlg1-interacting partner. Interaction was confirmed by in situ proximity ligation assays. Furthermore, AP-1 and VWF immunoprecipitate and colocalize with Dlg1 in the juxtanuclear zone. Finally, Dlg1 depletion by siRNA duplexes disrupts trans-Golgi network morphology and WPB formation. Our results provide the first evidence for an unexpected role of Dlg1 in controlling the formation of specific secretory granules involved in VWF exocytosis in endothelial cells.

  7. Experiencing CMT in Software Production of Large and Complex Projects Issues in the Scalability of Software Production Management

    Institute of Scientific and Technical Information of China (English)

    ChristianArnault; BrunoMansoux; 等

    2001-01-01

    The configuration management tool CMT has been used since several years now,and in quits different projects(Virgo,GLAST,LHCb,Auger,Atlas,etc).The features of the tool have continuously evolved according to the growing needs of the developers and to follow the increasing complexity of the software bases it has to service,However the original concepts:readability,simplicity,flexibility,completeness have been preserved and the syntan of the core element of the system-the requirements file-has been always ketp backward compatible.More and more project specific conventions and needs have founr their expression using CMT,and simultaneously the focuese to CMT features have evolved accordingly,progressively raising importance towards language customisation,new document generators production of patterns,package organization and software distribution.The basic properties of the CMT toolkit will be shortly presented but the focus of the discussion will be set to the CMT toolkit will be shortly presented but the focus of the discussion will be set top these recent evolutions,throught some typical examples obtained from actual projects showing specific definitions or conventions.The discussion is then extended towards the generalized question of the scalability in software production and management in the context of e.g. Grid technologies.The impact of using generic and high level tools such as CMT,which already offers several solutions,RPM or the Grid technologies,in this respect will be presented.In particular,the role of formal specifications for the software configuration appears to be critical for query mechanisms required in management operations or in remote actions.

  8. Large capacity, multi-fuel, and high temperature working fluid heaters to optimize CSP plant cost, complexity and annual generation

    Science.gov (United States)

    Peterseim, J. H.; Viscuso, L.; Hellwig, U.; McIntyre, P.

    2016-05-01

    This paper analyses the potential to optimize high temperature fluid back-up systems for concentrating solar power (CSP) plants by investigating the cost impact of component capacity and the impact of using multiple fuels on annual generation. Until now back-up heaters have been limited to 20MWth capacity but larger units have been realised in other industries. Installing larger units yields economy-of-scale benefits through improved manufacturing, optimised transport, and minimized on-site installation work. Halving the number of back-up boilers can yield cost reduction of 23% while minimizing plant complexity and on-site construction risk. However, to achieve these benefits it is important to adapt the back-up heaters to the plant's requirements (load change, capacity, minimum load, etc.) and design for manufacture, transport and assembly. Despite the fact that biomass availability is decreasing with increasing direct normal irradiance (DNI), some biomass is available in areas suitable for CSP plants. The use of these biomass resources is beneficial to maximise annual renewable energy generation, substitute natural gas, and use locally/seasonally available biomass resources that may not be used otherwise. Even small biomass quantities of only 50,000 t/a can increase the capacity factor of a 50MWe parabolic trough plant with 7h thermal energy storage from 40 to 49%. This is a valuable increase and such a concept is suitable for new plants and retrofit applications. However, similar to the capacity optimisation of back-up heaters, various design criteria have to be considered to ensure a successful project.

  9. Network MIMO with Linear Zero-Forcing Beamforming: Large System Analysis, Impact of Channel Estimation and Reduced-Complexity Scheduling

    CERN Document Server

    Huh, Hoon; Caire, Giuseppe

    2010-01-01

    We consider the downlink of a multi-cell system with multi-antenna base stations and single-antenna user terminals, arbitrary base station cooperation clusters, distance-dependent propagation pathloss, and general "fairness" requirements. We focus on the joint transmission from the base stations in a cooperation cluster based on linear zero-forcing beamforming, subject to sum or per-base station power constraints. Analytic expressions for the system spectral efficiency are found in the large-system limit where both the numbers of users and antennas per base station tend to infinity with a given ratio. In particular, for the per-base station constraint, we find new results in random matrix theory, yielding the squared Frobenius norm of submatrices of the Moore-Penrose pseudo-inverse for the structured non-i.i.d. channel matrix resulting from the cooperation cluster, user distribution, and path-loss coefficients. The analysis is extended to the case of non-ideal channel state information obtained through explic...

  10. Wide allelic heterogeneity with predominance of large IDS gene complex rearrangements in a sample of Mexican patients with Hunter syndrome.

    Science.gov (United States)

    Alcántara-Ortigoza, M A; García-de Teresa, B; González-Del Angel, A; Berumen, J; Guardado-Estrada, M; Fernández-Hernández, L; Navarrete-Martínez, J I; Maza-Morales, M; Rius-Domínguez, R

    2016-05-01

    Hunter syndrome or mucopolysaccharidosis type II (MPSII) is caused by pathogenic variants in the IDS gene. This is the first study that examines the mutational spectrum in 25 unrelated Mexican MPSII families. The responsible genotype was identified in 96% of the families (24/25) with 10 novel pathogenic variants: c.133G>C, c.1003C>T, c.1025A>C, c.463_464delinsCCGTATAGCTGG, c.754_767del, c.1132_1133del, c.1463del, c.508-1G>C, c.1006+1G>T and c.(-217_103del). Extensive IDS gene deletions were identified in four patients; using DNA microarray analysis two patients showed the loss of the entire AFF2 gene, and epilepsy developed in only one of them. Wide allelic heterogeneity was noted, with large gene alterations (e.g. IDS/IDSP1 gene inversions, partial to extensive IDS deletions, and one chimeric IDS-IDSP1 allele) that occurred at higher frequencies than previously reported (36% vs 18.9-29%). The frequency of carrier mothers (80%) is consistent with previous descriptions (>70%). Carrier assignment allowed molecular prenatal diagnoses. Notably, somatic and germline mosaicism was identified in one family, and two patients presented thrombocytopenic purpura and pancytopenia after idursulfase enzyme replacement treatment. Our findings suggest a wide allelic heterogeneity in Mexican MPSII patients; DNA microarray analysis contributes to further delineation of the resulting phenotype for IDS and neighboring loci deletions.

  11. Detection of driver protein complexes in breast cancer metastasis by large-scale transcriptome-interactome integration.

    Science.gov (United States)

    Garcia, Maxime; Finetti, Pascal; Bertucci, Francois; Birnbaum, Daniel; Bidaut, Ghislain

    2014-01-01

    With the development of high-throughput gene expression profiling technologies came the opportunity to define genomic signatures predicting clinical condition or cancer patient outcome. However, such signatures show dependency on training set, lack of generalization, and instability, partly due to microarray data topology. Additional issues for analyzing tumor gene expression are that subtle molecular perturbations in driver genes leading to cancer and metastasis (masked in typical differential expression analysis) may provoke expression changes of greater amplitude in downstream genes (easily detected). In this chapter, we are describing an interactome-based algorithm, Interactome-Transcriptome Integration (ITI) that is used to find a generalizable signature for prediction of breast cancer relapse by superimposition of a large-scale protein-protein interaction data (human interactome) over several gene expression datasets. ITI extracts regions in the interactome whose expression is discriminating for predicting relapse-free survival in cancer and allow detection of subnetworks that constitutes a generalizable and stable genomic signature. In this chapter, we describe the practical aspects of running the full ITI pipeline (subnetwork detection and classification) on six microarray datasets.

  12. A Large-scale Tertiary Salt Nappe Complex in the Leading Edge of the Kuqa Foreland Fold-Thrust Belt, the Tarim Basin, Northwest China

    Institute of Scientific and Technical Information of China (English)

    TANG Liangjie; JIN Zhijun; JIA Chengzao; PI Xuejun; CHEN Shuping; XIE Huiwen; WANG Ziyu

    2004-01-01

    The tectono-stratigraphic sequences of the Kuqa foreland fold-thrust belt in the northern Tarim basin,northwest China, can be divided into the Mesozoic sub-salt sequence, the Paleocene-Eocene salt sequence and the Oligocene-Quaternary supra-salt sequence. The salt sequence is composed mainly of light grey halite, gypsum, marl and brown clastics. A variety of salt-related structures have developed in the Kuqa foreland fold belt, in which the most fascinating structures are salt nappe complex. Based on field observation, seismic interpretation and drilling data, a large-scale salt nappe complex has been identified. It trends approximately east-west for over 200 km and occurs along the west Qiulitag Mountains. Its thrusting displacement is over 30 km. The salt nappe complex appears as an arcuate zone projecting southwestwards along the leading edge of the Kuqa foreland fold belt. The major thrust fault is developed along the Paleocene-Eocene salt beds. The allochthonous nappes comprise large north-dipping faulting monoclines which are made up of Paleocene-Pliocene sediments. Geological analysis and cross-section restoration revealed that the salt nappes were mainly formed at the late Himalayan stage (c.a. 1.64 Ma BP) and have been active until the present day. Because of inhomogeneous thrusting, a great difference may exist in thrust displacement, thrust occurrence, superimposition of allochthonous and autochthonous sequences and the development of the salt-related structures, which indicates the segmentation along the salt nappes. Regional compression, gravitational gliding and spreading controlled the formation and evolution of the salt nappe complex in the Kuqa foreland fold belt.

  13. Environmental assessment of a large industrial marine complex based on a community of benthic filter-feeders.

    Science.gov (United States)

    Carballo, José Luis; Naranjo, Santiago

    2002-07-01

    Biological quality in a bay affected by man's activities was evaluated by means of the composition of assemblages of sponges and ascidians. Our results showed that the structure of these two groups of filter-feeders aided in discriminating between undisturbed and disturbed areas, establishing different "environmental health categories" from moderately to strongly disturbed areas, and in ascertaining the extension of the area of each "health category". We were able to divide the bay into four zones based on type of disturbance or anthropogenic source: (1) stations free of any source of disturbance, (2) stations under moderate disturbance, located close to industrial ports, millworks, etc., (3) stations that are under the direct influence of industrial wastes such as a power station and oil refinery, and (4) stations near strongly disturbed areas, influenced directly by harmful steelworks activities. We differentiated clearly between four large species assemblages, and related the composition of these assemblages to different kinds of disturbances. Thus, these species could be used to manage the marine environment in this bay by comparing the observed fauna, with expected fauna in an unstressed site. Moreover, the joint presence of the sponge Cliona vastifica and tunicate Policitor adriaticum seems always to indicate a more or less pristine environmental situation, functioning as bioindicators of normal conditions. We think that the use of specific bioindicators for monitoring disturbance is a valid tool to establish baselines to predict impacts associated with industrial development in many marine ecosystems. The advantages to monitoring communities on hard rocks versus sandy or muddy bottoms are also commented upon.

  14. Constructing an Interpolated Potential Energy Surface of a Large Molecule: A Case Study with Bacteriochlorophyll a Model in the Fenna-Matthews-Olson Complex.

    Science.gov (United States)

    Kim, Chang Woo; Rhee, Young Min

    2016-11-08

    Constructing a reliable potential energy surface (PES) is a key step toward computationally studying the chemical dynamics of any molecular system. The interpolation scheme is a useful tool that can closely follow the accuracy of quantum chemical means at a dramatically reduced computational cost. However, applying interpolation to building a PES of a large molecule is not a straightforward black-box approach, as it frequently encounters practical difficulties associated with its large dimensionality. Here, we present detailed courses of applying interpolation toward building a PES of a large chromophore molecule. We take the example of S0 and S1 electronic states of bacteriochlorophyll a (BChla) molecules in the Fenna-Matthews-Olson light harvesting complex. With a reduced model molecule that bears BChla's main π-conjugated ring, various practical approaches are designed for improving the PES quality in a stable manner and for fine-tuning the final surface such that the surface can be adopted for long time molecular dynamics simulations. Combined with parallel implementation, we show that interpolated mechanics/molecular mechanics (IM/MM) simulations of the entire complex in the nanosecond time scale can be conducted readily without any practical issues. With 1500 interpolation data points for each chromophore unit, the PES error relative to the reference quantum chemical calculation is found to be ∼0.15 eV in the thermally accessible region of the conformational space, together with ∼0.01 eV error in S0 - S1 transition energies. The performance issue related to the use of a large interpolation database within the framework of our parallel routines is also discussed.

  15. Early evolution of large micro-organisms with cytological complexity revealed by microanalyses of 3.4 Ga organic-walled microfossils.

    Science.gov (United States)

    Sugitani, K; Mimura, K; Takeuchi, M; Lepot, K; Ito, S; Javaux, E J

    2015-11-01

    The Strelley Pool Formation (SPF) is widely distributed in the East Pilbara Terrane (EPT) of the Pilbara Craton, Western Australia, and represents a Paleoarchean shallow-water to subaerial environment. It was deposited ~3.4 billion years ago and displays well-documented carbonate stromatolites. Diverse putative microfossils (SPF microfossils) were recently reported from several localities in the East Strelley, Panorama, Warralong, and Goldsworthy greenstone belts. Thus, the SPF provides unparalleled opportunities to gain insights into a shallow-water to subaerial ecosystem on the early Earth. Our new micro- to nanoscale ultrastructural and microchemical studies of the SPF microfossils show that large (20-70 μm) lenticular organic-walled flanged microfossils retain their structural integrity, morphology, and chain-like arrangements after acid (HF-HCl) extraction (palynology). Scanning and transmitted electron microscopy of extracted microfossils revealed that the central lenticular body is either alveolar or hollow, and the wall is continuous with the surrounding smooth to reticulated discoidal flange. These features demonstrate the evolution of large micro-organisms able to form an acid-resistant recalcitrant envelope or cell wall with complex morphology and to form colonial chains in the Paleoarchean era. This study provides evidence of the evolution of very early and remarkable biological innovations, well before the presumed late emergence of complex cells.

  16. Epigenetic silencing of the proapoptotic gene BIM in anaplastic large cell lymphoma through an MeCP2/SIN3a deacetylating complex.

    Science.gov (United States)

    Piazza, Rocco; Magistroni, Vera; Mogavero, Angela; Andreoni, Federica; Ambrogio, Chiara; Chiarle, Roberto; Mologni, Luca; Bachmann, Petra S; Lock, Richard B; Collini, Paola; Pelosi, Giuseppe; Gambacorti-Passerini, Carlo

    2013-05-01

    BIM is a proapoptotic member of the Bcl-2 family. Here, we investigated the epigenetic status of the BIM locus in NPM/ALK+ anaplastic large cell lymphoma (ALCL) cell lines and in lymph node biopsies from NPM/ALK+ ALCL patients. We show that BIM is epigenetically silenced in cell lines and lymph node specimens and that treatment with the deacetylase inhibitor trichostatin A restores the histone acetylation, strongly upregulates BIM expression, and induces cell death. BIM silencing occurs through recruitment of MeCP2 and the SIN3a/histone deacetylase 1/2 (HDAC1/2) corepressor complex. This event requires BIM CpG methylation/demethylation with 5-azacytidine that leads to detachment of the MeCP2 corepressor complex and reacetylation of the histone tails. Treatment with the ALK inhibitor PF2341066 or with an inducible shRNA targeting NPM/ALK does not restore BIM locus reacetylation; however, enforced expression of NPM/ALK in an NPM/ALK-negative cell line significantly increases the methylation at the BIM locus. This study demonstrates that BIM is epigenetically silenced in NPM/ALK-positive cells through recruitment of the SIN3a/HDAC1/2 corepressor complex and that NPM/ALK is dispensable to maintain BIM epigenetic silencing but is able to act as an inducer of BIM methylation.

  17. Epigenetic Silencing of the Proapoptotic Gene BIM in Anaplastic Large Cell Lymphoma through an MeCP2/SIN3a Deacetylating Complex

    Directory of Open Access Journals (Sweden)

    Rocco Piazza

    2013-05-01

    Full Text Available BIM is a proapoptotic member of the Bcl-2 family. Here, we investigated the epigenetic status of the BIM locus in NPM/ALK+ anaplastic large cell lymphoma (ALCL cell lines and in lymph node biopsies from NPM/ALK+ ALCL patients. We show that BIM is epigenetically silenced in cell lines and lymph node specimens and that treatment with the deacetylase inhibitor trichostatin A restores the histone acetylation, strongly upregulates BIM expression, and induces cell death. BIM silencing occurs through recruitment of MeCP2 and the SIN3a/histone deacetylase 1/2 (HDAC1/2 corepressor complex. This event requires BIM CpG methylation/demethylation with 5-azacytidine that leads to detachment of the MeCP2 corepressor complex and reacetylation of the histone tails. Treatment with the ALK inhibitor PF2341066 or with an inducible shRNA targeting NPM/ALK does not restore BIM locus reacetylation; however, enforced expression of NPM/ALK in an NPM/ALK-negative cell line significantly increases the methylation at the BIM locus. This study demonstrates that BIM is epigenetically silenced in NPM/ALK-positive cells through recruitment of the SIN3a/HDAC1/2 corepressor complex and that NPM/ALK is dispensable to maintain BIM epigenetic silencing but is able to act as an inducer of BIM methylation.

  18. Results of volume-staged fractionated Gamma Knife radiosurgery for large complex arteriovenous malformations: obliteration rates and clinical outcomes of an evolving treatment paradigm.

    Science.gov (United States)

    Franzin, Alberto; Panni, Pietro; Spatola, Giorgio; Vecchio, Antonella Del; Gallotti, Alberto L; Gigliotti, Carmen R; Cavalli, Andrea; Donofrio, Carmine A; Mortini, Pietro

    2016-12-01

    OBJECTIVE There are few reported series regarding volume-staged Gamma Knife radiosurgery (GKRS) for the treatment of large, complex, cerebral arteriovenous malformations (AVMs). The object of this study was to report the results of using volume-staged Gamma Knife radiosurgery for patients affected by large and complex AVMs. METHODS Data from 20 patients with large AVMs were prospectively included in the authors' AVM database between 2004 and 2012. A staging strategy was used when treating lesion volumes larger than 10 cm(3). Hemorrhage and seizures were the presenting clinical feature for 6 (30%) and 8 (40%) patients, respectively. The median AVM volume was 15.9 cm(3) (range 10.1-34.3 cm(3)). The mean interval between stages (± standard deviation) was 15 months (± 9 months). The median margin dose for each stage was 20 Gy (range 18-25 Gy). RESULTS Obliteration was confirmed in 8 (42%) patients after a mean follow-up of 45 months (range 19-87 months). A significant reduction (> 75%) of the original nidal volume was achieved in 4 (20%) patients. Engel Class I-II seizure status was reported by 75% of patients presenting with seizures (50% Engel Class I and 25% Engel Class II) after radiosurgery. After radiosurgery, 71.5% (5/7) of patients who had presented with a worsening neurological deficit reported a complete resolution or amelioration. None of the patients who presented acutely because of hemorrhage experienced a new bleeding episode during follow-up. One (5%) patient developed radionecrosis that caused sensorimotor hemisyndrome. Two (10%) patients sustained a bleeding episode after GKRS, although only 1 (5%) was symptomatic. High nidal flow rate and a time interval between stages of less than 11.7 months were factors significantly associated with AVM obliteration (p = 0.021 and p = 0.041, respectively). Patient age younger than 44 years was significantly associated with a greater than 75% reduction in AVM volume but not with AVM obliteration (p = 0

  19. Properties and modeling of GWAS when complex disease risk is due to non-complementing, deleterious mutations in genes of large effect.

    Directory of Open Access Journals (Sweden)

    Kevin R Thornton

    Full Text Available Current genome-wide association studies (GWAS have high power to detect intermediate frequency SNPs making modest contributions to complex disease, but they are underpowered to detect rare alleles of large effect (RALE. This has led to speculation that the bulk of variation for most complex diseases is due to RALE. One concern with existing models of RALE is that they do not make explicit assumptions about the evolution of a phenotype and its molecular basis. Rather, much of the existing literature relies on arbitrary mapping of phenotypes onto genotypes obtained either from standard population-genetic simulation tools or from non-genetic models. We introduce a novel simulation of a 100-kilobase gene region, based on the standard definition of a gene, in which mutations are unconditionally deleterious, are continuously arising, have partially recessive and non-complementing effects on phenotype (analogous to what is widely observed for most Mendelian disorders, and are interspersed with neutral markers that can be genotyped. Genes evolving according to this model exhibit a characteristic GWAS signature consisting of an excess of marginally significant markers. Existing tests for an excess burden of rare alleles in cases have low power while a simple new statistic has high power to identify disease genes evolving under our model. The structure of linkage disequilibrium between causative mutations and significantly associated markers under our model differs fundamentally from that seen when rare causative markers are assumed to be neutral. Rather than tagging single haplotypes bearing a large number of rare causative alleles, we find that significant SNPs in a GWAS tend to tag single causative mutations of small effect relative to other mutations in the same gene. Our results emphasize the importance of evaluating the power to detect associations under models that are genetically and evolutionarily motivated.

  20. Nuclear export signal-interacting protein forms complexes with lamin A/C-Nups to mediate the CRM1-independent nuclear export of large hepatitis delta antigen.

    Science.gov (United States)

    Huang, Cheng; Jiang, Jia-Yin; Chang, Shin C; Tsay, Yeou-Guang; Chen, Mei-Ru; Chang, Ming-Fu

    2013-02-01

    Nuclear export is an important process that not only regulates the functions of cellular factors but also facilitates the assembly of viral nucleoprotein complexes. Chromosome region maintenance 1 (CRM1) that mediates the transport of proteins bearing the classical leucine-rich nuclear export signal (NES) is the best-characterized nuclear export receptor. Recently, several CRM1-independent nuclear export pathways were also identified. The nuclear export of the large form of hepatitis delta antigen (HDAg-L), a nucleocapsid protein of hepatitis delta virus (HDV), which contains a CRM1-independent proline-rich NES, is mediated by the host NES-interacting protein (NESI). The mechanism of the NESI protein in mediating nuclear export is still unknown. In this study, NESI was characterized as a highly glycosylated membrane protein. It interacted and colocalized well in the nuclear envelope with lamin A/C and nucleoporins. Importantly, HDAg-L could be coimmunoprecipitated with lamin A/C and nucleoporins. In addition, binding of the cargo HDAg-L to the C terminus of NESI was detected for the wild-type protein but not for the nuclear export-defective HDAg-L carrying a P205A mutation [HDAg-L(P205A)]. Knockdown of lamin A/C effectively reduced the nuclear export of HDAg-L and the assembly of HDV. These data indicate that by forming complexes with lamin A/C and nucleoporins, NESI facilitates the CRM1-independent nuclear export of HDAg-L.

  1. Experiences in running a complex electronic data capture system using mobile phones in a large-scale population trial in southern Nepal.

    Science.gov (United States)

    Style, Sarah; Beard, B James; Harris-Fry, Helen; Sengupta, Aman; Jha, Sonali; Shrestha, Bhim P; Rai, Anjana; Paudel, Vikas; Thondoo, Meelan; Pulkki-Brannstrom, Anni-Maria; Skordis-Worrall, Jolene; Manandhar, Dharma S; Costello, Anthony; Saville, Naomi M

    2017-01-01

    The increasing availability and capabilities of mobile phones make them a feasible means of data collection. Electronic Data Capture (EDC) systems have been used widely for public health monitoring and surveillance activities, but documentation of their use in complicated research studies requiring multiple systems is limited. This paper shares our experiences of designing and implementing a complex multi-component EDC system for a community-based four-armed cluster-Randomised Controlled Trial in the rural plains of Nepal, to help other researchers planning to use EDC for complex studies in low-income settings. We designed and implemented three interrelated mobile phone data collection systems to enrol and follow-up pregnant women (trial participants), and to support the implementation of trial interventions (women's groups, food and cash transfers). 720 field staff used basic phones to send simple coded text messages, 539 women's group facilitators used Android smartphones with Open Data Kit Collect, and 112 Interviewers, Coordinators and Supervisors used smartphones with CommCare. Barcoded photo ID cards encoded with participant information were generated for each enrolled woman. Automated systems were developed to download, recode and merge data for nearly real-time access by researchers. The systems were successfully rolled out and used by 1371 staff. A total of 25,089 pregnant women were enrolled, and 17,839 follow-up forms completed. Women's group facilitators recorded 5717 women's groups and the distribution of 14,647 food and 13,482 cash transfers. Using EDC sped up data collection and processing, although time needed for programming and set-up delayed the study inception. EDC using three interlinked mobile data management systems (FrontlineSMS, ODK and CommCare) was a feasible and effective method of data capture in a complex large-scale trial in the plains of Nepal. Despite challenges including prolonged set-up times, the systems met multiple data

  2. CARMA1- and MyD88-dependent activation of Jun/ATF-type AP-1 complexes is a hallmark of ABC diffuse large B-cell lymphomas.

    Science.gov (United States)

    Juilland, Mélanie; Gonzalez, Montserrat; Erdmann, Tabea; Banz, Yara; Jevnikar, Zala; Hailfinger, Stephan; Tzankov, Alexandar; Grau, Michael; Lenz, Georg; Novak, Urban; Thome, Margot

    2016-04-07

    A hallmark of the diffuse large B-cell lymphoma (DLBCL) of the activated B-cell (ABC) type, a molecular subtype characterized by adverse outcome, is constitutive activation of the transcription factor nuclear factor-κB (NF-κB), which controls expression of genes promoting cellular survival and proliferation. Much less, however, is known about the role of the transcription factor activator protein-1 (AP-1) in ABC DLBCL. Here, we show that AP-1, like NF-κB, was controlled by constitutive activation of the B-cell receptor signaling component caspase recruitment domain-containing membrane-associated guanylate kinase 1 (CARMA1) and/or the Toll-like receptor signaling component myeloid differentiation primary response gene 88 (MyD88) in ABC DLBCL cell lines. In contrast to germinal center (GC) B-cell (GCB) DLBCL, ABC DLBCL cell lines expressed high levels of the AP-1 family members c-Jun, JunB, and JunD, which formed heterodimeric complexes with the AP-1 family members activating transcription factor (ATF) 2, ATF3, and ATF7. Inhibition of these complexes by a dominant-negative approach led to impaired growth of a majority of ABC DLBCL cell lines. Individual silencing of c-Jun, ATF2, or ATF3 decreased cellular survival and revealed c-Jun/ATF2-dependent control of ATF3 expression. As a consequence, ATF3 expression was much higher in ABC vs GCB DLBCL cell lines. Samples derived from DLBCL patients showed a clear trend toward high and nuclear ATF3 expression in nodal DLBCL of the non-GC or ABC subtype. These findings identify the activation of AP-1 complexes of the Jun/ATF-type as an important element controlling the growth of ABC DLBCL. © 2016 by The American Society of Hematology.

  3. Enantioselective column coupled electrophoresis employing large bore capillaries hyphenated with tandem mass spectrometry for ultra-trace determination of chiral compounds in complex real samples.

    Science.gov (United States)

    Piešťanský, Juraj; Maráková, Katarína; Kovaľ, Marián; Havránek, Emil; Mikuš, Peter

    2015-12-01

    A new multidimensional analytical approach for the ultra-trace determination of target chiral compounds in unpretreated complex real samples was developed in this work. The proposed analytical system provided high orthogonality due to on-line combination of three different methods (separation mechanisms), i.e. (1) isotachophoresis (ITP), (2) chiral capillary zone electrophoresis (chiral CZE), and (3) triple quadrupole mass spectrometry (QqQ MS). The ITP step, performed in a large bore capillary (800 μm), was utilized for the effective sample pretreatment (preconcentration and matrix clean-up) in a large injection volume (1-10 μL) enabling to obtain as low as ca. 80 pg/mL limits of detection for the target enantiomers in urine matrices. In the chiral CZE step, the different chiral selectors (neutral, ionizable, and permanently charged cyclodextrins) and buffer systems were tested in terms of enantioselectivity and influence on the MS detection response. The performance parameters of the optimized ITP - chiral CZE-QqQ MS method were evaluated according to the FDA guidance for bioanalytical method validation. Successful validation and application (enantioselective monitoring of renally eliminated pheniramine and its metabolite in human urine) highlighted great potential of this chiral approach in advanced enantioselective biomedical applications.

  4. Large structures at high resolution: the 1.6 A crystal structure of spinach ribulose-1,5-bisphosphate carboxylase/oxygenase complexed with 2-carboxyarabinitol bisphosphate.

    Science.gov (United States)

    Andersson, I

    1996-05-31

    Ribulose-1,5-bisphosphate carboxylase/oxygenase (rubisco) from spinach is a hexadecamer (L8S8, Mr = 550,000) consisting of eight large (L, 475 residues) and eight small subunits (S, 123 residues). High-resolution data collection on crystals with large unit cells is not a trivial task due to the effect of radiation damage and the large number of overlapping reflections when conventional data collection methods are used. In order to minimise these effects, data on rubisco were collected with a giant Weissenberg camera at long crystal to image-plate distances at the synchrotron of the Photon Factory, Japan. Relative to conventional data sets, this experimental arrangement allowed a 20 to 30-fold reduction of the X-ray dose/exposure time for data collection. This paper describes the refined 1.6 A crystal structure of activated rubisco complexed with a transition state analogue, 2-carboxyarabinitol-bisphosphate. The crystallographic asymmetric unit contains an L4S4 unit, representing half of the molecule. The structure presented here is currently the highest resolution structure for any protein of comparable size. Refinement of the model was carried out by restrained least squares techniques without non-crystallographic symmetry averaging. The results show that all L and S subunits have identical three-dimensional structures, and their arrangement within the hexadecamer has no intrinsic asymmetry. A detailed analysis of the high-resolution maps identified 30 differences in the sequence of the small subunit, indicating a larger than usual heterogeneity for this nuclear encoded protein in spinach. No such differences were found in the sequence of the chloroplast encoded large subunit. The transition state analogue is in the cis conformation at the active site suggesting a key role for the carbamate of Lys201 in catalysis. Analysis of the active site around the catalytically essential magnesium ion further indicates that residues in the second liganding sphere of the metal

  5. Annotation-based genome-wide SNP discovery in the large and complex Aegilops tauschii genome using next-generation sequencing without a reference genome sequence

    Directory of Open Access Journals (Sweden)

    Luo Ming-Cheng

    2011-01-01

    Full Text Available Abstract Background Many plants have large and complex genomes with an abundance of repeated sequences. Many plants are also polyploid. Both of these attributes typify the genome architecture in the tribe Triticeae, whose members include economically important wheat, rye and barley. Large genome sizes, an abundance of repeated sequences, and polyploidy present challenges to genome-wide SNP discovery using next-generation sequencing (NGS of total genomic DNA by making alignment and clustering of short reads generated by the NGS platforms difficult, particularly in the absence of a reference genome sequence. Results An annotation-based, genome-wide SNP discovery pipeline is reported using NGS data for large and complex genomes without a reference genome sequence. Roche 454 shotgun reads with low genome coverage of one genotype are annotated in order to distinguish single-copy sequences and repeat junctions from repetitive sequences and sequences shared by paralogous genes. Multiple genome equivalents of shotgun reads of another genotype generated with SOLiD or Solexa are then mapped to the annotated Roche 454 reads to identify putative SNPs. A pipeline program package, AGSNP, was developed and used for genome-wide SNP discovery in Aegilops tauschii-the diploid source of the wheat D genome, and with a genome size of 4.02 Gb, of which 90% is repetitive sequences. Genomic DNA of Ae. tauschii accession AL8/78 was sequenced with the Roche 454 NGS platform. Genomic DNA and cDNA of Ae. tauschii accession AS75 was sequenced primarily with SOLiD, although some Solexa and Roche 454 genomic sequences were also generated. A total of 195,631 putative SNPs were discovered in gene sequences, 155,580 putative SNPs were discovered in uncharacterized single-copy regions, and another 145,907 putative SNPs were discovered in repeat junctions. These SNPs were dispersed across the entire Ae. tauschii genome. To assess the false positive SNP discovery rate, DNA

  6. 苏州合景大型商业综合体结构设计%Structural design of Hejing Large Commercial Complex in Suzhou

    Institute of Scientific and Technical Information of China (English)

    周慧鑫; 王干; 赵建忠; 赵振平; 王克拾

    2016-01-01

    Hejing Large Commercial Complex in Suzhou has three layers underground,and upper podium is an 8-layer frame structure.The tower is a 22-layer frame-shear wall structure with a total height of 93.190m.The project structure shape is irregular and complex.Software of PKPM and ETABS were used to conduct structure calculation and analysis under the frequent,fortification and rare earthquakes,and the Pushover analysis,temperature stress analysis were conducted on the structure.The calculation results show that the performance of the structure can be achieved by a variety of software calculation and analysis as well as the targeted strengthening measures,which ensure the safety and seismic performance of the structure.%苏州合景大型商业综合体地下3层,地上裙房为8层框架结构,塔楼为22层框架-剪力墙结构,总高度93.190m.本项目结构形状不规则,体型复杂,通过PKPM,ETABS软件进行多遇地震、设防烈度地震、罕遇地震下的结构计算分析,并对结构进行Pushover分析、温度应力分析.计算结果表明,通过多种软件计算分析以及采取有针对性的加强措施,能够实现结构预定的性能设计目标,保证了结构的安全及抗震性能.

  7. Evaluating the impact of a disease management program for chronic complex conditions at two large northeast health plans using a control group methodology.

    Science.gov (United States)

    Schwerner, Henry; Mellody, Timothy; Goldstein, Allan B; Wansink, Daryl; Sullivan, Virginia; Yelenik, Stephan N; Charlton, Warwick; Lloyd, Kelley; Courtemanche, Ted

    2006-02-01

    The objective of this study was to observe trends in payer expenditures for plan members with one of 14 chronic, complex conditions comparing one group with a disease management program specific to their condition (the intervention group) and the other with no specific disease management program (the control group) for these conditions. The authors used payer claims and membership data to identify members eligible for the program in a 12-month baseline year (October 2001 to September 2002) and a subsequent 12-month program year (October 2002 to September 2003). Two payers were analyzed: one health plan with members primarily in New Jersey (AmeriHealth New Jersey [AHNJ]), where the disease management program was offered, and one affiliated large plan with members primarily in the metro Philadelphia area, where the program was not offered. The claims payment policy for both plans is identical. Intervention and control groups were analyzed for equivalence. The analysis was conducted in both groups over identical time periods. The intervention group showed statistically significant (p control group. Intervention group members showed a reduction in expenditures of -8%, while control group members showed an increase of +10% over identical time periods. Subsequent analyses controlling for outliers and product lines served to confirm the overall results. The disease management program is likely responsible for the observed difference between the intervention and control group results. A well-designed, targeted disease management program offered by a motivated, supportive health plan can play an important role in cost improvement strategies for members with complex, chronic conditions.

  8. Collaborating CPU and GPU for large-scale high-order CFD simulations with complex grids on the TianHe-1A supercomputer

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Chuanfu, E-mail: xuchuanfu@nudt.edu.cn [College of Computer Science, National University of Defense Technology, Changsha 410073 (China); Deng, Xiaogang; Zhang, Lilun [College of Computer Science, National University of Defense Technology, Changsha 410073 (China); Fang, Jianbin [Parallel and Distributed Systems Group, Delft University of Technology, Delft 2628CD (Netherlands); Wang, Guangxue; Jiang, Yi [State Key Laboratory of Aerodynamics, P.O. Box 211, Mianyang 621000 (China); Cao, Wei; Che, Yonggang; Wang, Yongxian; Wang, Zhenghua; Liu, Wei; Cheng, Xinghua [College of Computer Science, National University of Defense Technology, Changsha 410073 (China)

    2014-12-01

    Programming and optimizing complex, real-world CFD codes on current many-core accelerated HPC systems is very challenging, especially when collaborating CPUs and accelerators to fully tap the potential of heterogeneous systems. In this paper, with a tri-level hybrid and heterogeneous programming model using MPI + OpenMP + CUDA, we port and optimize our high-order multi-block structured CFD software HOSTA on the GPU-accelerated TianHe-1A supercomputer. HOSTA adopts two self-developed high-order compact definite difference schemes WCNS and HDCS that can simulate flows with complex geometries. We present a dual-level parallelization scheme for efficient multi-block computation on GPUs and perform particular kernel optimizations for high-order CFD schemes. The GPU-only approach achieves a speedup of about 1.3 when comparing one Tesla M2050 GPU with two Xeon X5670 CPUs. To achieve a greater speedup, we collaborate CPU and GPU for HOSTA instead of using a naive GPU-only approach. We present a novel scheme to balance the loads between the store-poor GPU and the store-rich CPU. Taking CPU and GPU load balance into account, we improve the maximum simulation problem size per TianHe-1A node for HOSTA by 2.3×, meanwhile the collaborative approach can improve the performance by around 45% compared to the GPU-only approach. Further, to scale HOSTA on TianHe-1A, we propose a gather/scatter optimization to minimize PCI-e data transfer times for ghost and singularity data of 3D grid blocks, and overlap the collaborative computation and communication as far as possible using some advanced CUDA and MPI features. Scalability tests show that HOSTA can achieve a parallel efficiency of above 60% on 1024 TianHe-1A nodes. With our method, we have successfully simulated an EET high-lift airfoil configuration containing 800M cells and China's large civil airplane configuration containing 150M cells. To our best knowledge, those are the largest-scale CPU–GPU collaborative simulations

  9. Partial plasma cell differentiation as a mechanism of lost major histocompatibility complex class II expression in diffuse large B-cell lymphoma.

    Science.gov (United States)

    Wilkinson, Sarah T; Vanpatten, Kristie A; Fernandez, Diane R; Brunhoeber, Patrick; Garsha, Karl E; Glinsmann-Gibson, Betty J; Grogan, Thomas M; Teruya-Feldstein, Julie; Rimsza, Lisa M

    2012-02-09

    Loss of major histocompatibility complex class II (MHC II) expression is associated with poor patient outcome in diffuse large B-cell lymphoma (DLBCL). As MHC II molecules are lost with plasmacytic differentiation in normal cells, we asked whether MHC II loss in DLBCL is associated with an altered differentiation state. We used gene expression profiling, quantum dots, and immunohistochemistry to study the relationship between MHC II and plasma cell markers in DLBCL and plasmablastic lymphoma (PBL). Results demonstrate that MHC II(-) DLBCL immunophenotypically overlap with PBL and demonstrate an inverse correlation between MHC II and plasma cell markers MUM1, PRDM1/Blimp1, and XBP1s. In addition, MHC II expression is significantly higher in germinal center-DLBCL than activated B cell-DLBCL. A minor subset of cases with an unusual pattern of mislocalized punctate MHC II staining and intermediate levels of mRNA is also described. Finally, we show that PBL is negative for MHC II. The results imply a spectrum of MHC II expression that is more frequently diminished in tumors derived from B cells at the later stages of differentiation (with complete loss in PBL). Our observations provide a possible unifying concept that may contribute to the poor outcome reported in all MHC II(-) B-cell tumors.

  10. An atypical human induced pluripotent stem cell line with a complex, stable, and balanced genomic rearrangement including a large de novo 1q uniparental disomy.

    Science.gov (United States)

    Steichen, Clara; Maluenda, Jérôme; Tosca, Lucie; Luce, Eléanor; Pineau, Dominique; Dianat, Noushin; Hannoun, Zara; Tachdjian, Gérard; Melki, Judith; Dubart-Kupperschmitt, Anne

    2015-03-01

    Human induced pluripotent stem cells (hiPSCs) hold great promise for cell therapy through their use as vital tools for regenerative and personalized medicine. However, the genomic integrity of hiPSCs still raises some concern and is one of the barriers limiting their use in clinical applications. Numerous articles have reported the occurrence of aneuploidies, copy number variations, or single point mutations in hiPSCs, and nonintegrative reprogramming strategies have been developed to minimize the impact of the reprogramming process on the hiPSC genome. Here, we report the characterization of an hiPSC line generated by daily transfections of modified messenger RNAs, displaying several genomic abnormalities. Karyotype analysis showed a complex genomic rearrangement, which remained stable during long-term culture. Fluorescent in situ hybridization analyses were performed on the hiPSC line showing that this karyotype is balanced. Interestingly, single-nucleotide polymorphism analysis revealed the presence of a large 1q region of uniparental disomy (UPD), demonstrating for the first time that UPD can occur in a noncompensatory context during nonintegrative reprogramming of normal fibroblasts.

  11. A numerical method to compute derivatives of functions of large complex matrices and its application to the overlap Dirac operator at finite chemical potential

    Science.gov (United States)

    Puhr, Matthias; Buividovich, Pavel

    2016-11-01

    We present a method for the numerical calculation of derivatives of functions of general complex matrices. The method can be used in combination with any algorithm that evaluates or approximates the desired matrix function, in particular with implicit Krylov-Ritz-type approximations. An important use case for the method is the evaluation of the overlap Dirac operator in lattice Quantum Chromodynamics (QCD) at finite chemical potential, which requires the application of the sign function of a non-Hermitian matrix to some source vector. While the sign function of non-Hermitian matrices in practice cannot be efficiently approximated with source-independent polynomials or rational functions, sufficiently good approximating polynomials can still be constructed for each particular source vector. Our method allows for an efficient calculation of the derivatives of such implicit approximations with respect to the gauge field or other external parameters, which is necessary for the calculation of conserved lattice currents or the fermionic force in Hybrid Monte-Carlo or Langevin simulations. We also give an explicit deflation prescription for the case when one knows several eigenvalues and eigenvectors of the matrix being the argument of the differentiated function. We test the method for the two-sided Lanczos approximation of the finite-density overlap Dirac operator on realistic SU(3) gauge field configurations on lattices with sizes as large as 14 ×143 and 6 ×183.

  12. Resolving regional frequency analysis of precipitation at large and complex scales using a bottom-up approach: The Latin America and the Caribbean Drought Atlas

    Science.gov (United States)

    Núñez, J.; Hallack-Alegría, M.; Cadena, M.

    2016-07-01

    Hydrologic frequency analysis is a statistical technique for the assessment of natural hazards, particularly the so-called water hazards caused exclusively by extreme hydrologic events. In particular, L-moments based regional frequency analysis (RFA-LM) has being adopted as the standard method for hydrologic frequency analysis in many parts of the world and for many other applications relating to hydrological extremes. However, despite the widespread use of RFA-LM, its application at large network and high and complex spatial scale conditions (LNHCSSC) has been poorly studied. The lack of studies about RFA-LM under such conditions and its use preferentially at subnational scales and areas with low number of rain gauge stations, or based on grid data, may be explained by the fact that the most difficult, less robust, and most subjective stage of RFA-LM is the delineation of homogeneous regions. This work proposes an integral procedure for the application of RFA-LM under LNHCSSC. The proposed method is applied to the study of drought event frequency in three case studies from Latin America, and incorporates innovating aspects compared to the state-of-the-art RFA-LM. These aspects are specifically (a) the decoupling of the cause of homogeneity from the regionalization stage; (b) the proposal of regionalization efficiency metrics; (c) the development of a regionalization algorithm; and (d) the development of a frequency estimation and mapping method for ungauged sites.

  13. RAG and HMGB1 create a large bend in the 23RSS in the V(D)J recombination synaptic complexes.

    Science.gov (United States)

    Ciubotaru, Mihai; Trexler, Adam J; Spiridon, Laurentiu N; Surleac, Marius D; Rhoades, Elizabeth; Petrescu, Andrei J; Schatz, David G

    2013-02-01

    During V(D)J recombination, recombination activating gene proteins RAG1 and RAG2 generate DNA double strand breaks within a paired complex (PC) containing two complementary recombination signal sequences (RSSs), the 12RSS and 23RSS, which differ in the length of the spacer separating heptamer and nonamer elements. Despite the central role of the PC in V(D)J recombination, little is understood about its structure. Here, we use fluorescence resonance energy transfer to investigate the architecture of the 23RSS in the PC. Energy transfer was detected in 23RSS substrates in which the donor and acceptor fluorophores flanked the entire RSS, and was optimal under conditions that yield a cleavage-competent PC. The data are most easily explained by a dramatic bend in the 23RSS that reduces the distance between these flanking regions from >160 Å in the linear substrate to <80 Å in the PC. Analysis of multiple fluorescent substrates together with molecular dynamics modeling yielded a model in which the 23RSS adopts a U shape in the PC, with the spacer located centrally within the bend. We propose that this large bend facilitates simultaneous recognition of the heptamer and nonamer, is critical for proper positioning of the active site and contributes to the 12/23 rule.

  14. In various protein complexes, disordered protomers have large per-residue surface areas and area of protein-, DNA- and RNA-binding interfaces.

    Science.gov (United States)

    Wu, Zhonghua; Hu, Gang; Yang, Jianyi; Peng, Zhenling; Uversky, Vladimir N; Kurgan, Lukasz

    2015-09-14

    We provide first large scale analysis of the peculiarities of surface areas of 5658 dissimilar (below 50% sequence similarity) proteins with known 3D-structures that bind to proteins, DNA or RNAs. We show here that area of the protein surface is highly correlated with the protein length. The size of the interface surface is only modestly correlated with the protein size, except for RNA-binding proteins where larger proteins are characterized by larger interfaces. Disordered proteins with disordered interfaces are characterized by significantly larger per-residue areas of their surfaces and interfaces when compared to the structured proteins. These result are applicable for proteins involved in interaction with DNA, RNA, and proteins and suggest that disordered proteins and binding regions are less compact and more likely to assume extended shape. We demonstrate that disordered protein binding residues in the interfaces of disordered proteins drive the increase in the per residue area of these interfaces. Our results can be used to predict in silico whether a given protomer from the DNA, RNA or protein complex is likely to be disordered in its unbound form.

  15. Predictive Big Data Analytics: A Study of Parkinson’s Disease Using Large, Complex, Heterogeneous, Incongruent, Multi-Source and Incomplete Observations

    Science.gov (United States)

    Dinov, Ivo D.; Heavner, Ben; Tang, Ming; Glusman, Gustavo; Chard, Kyle; Darcy, Mike; Madduri, Ravi; Pa, Judy; Spino, Cathie; Kesselman, Carl; Foster, Ian; Deutsch, Eric W.; Price, Nathan D.; Van Horn, John D.; Ames, Joseph; Clark, Kristi; Hood, Leroy; Hampstead, Benjamin M.; Dauer, William; Toga, Arthur W.

    2016-01-01

    Background A unique archive of Big Data on Parkinson’s Disease is collected, managed and disseminated by the Parkinson’s Progression Markers Initiative (PPMI). The integration of such complex and heterogeneous Big Data from multiple sources offers unparalleled opportunities to study the early stages of prevalent neurodegenerative processes, track their progression and quickly identify the efficacies of alternative treatments. Many previous human and animal studies have examined the relationship of Parkinson’s disease (PD) risk to trauma, genetics, environment, co-morbidities, or life style. The defining characteristics of Big Data–large size, incongruency, incompleteness, complexity, multiplicity of scales, and heterogeneity of information-generating sources–all pose challenges to the classical techniques for data management, processing, visualization and interpretation. We propose, implement, test and validate complementary model-based and model-free approaches for PD classification and prediction. To explore PD risk using Big Data methodology, we jointly processed complex PPMI imaging, genetics, clinical and demographic data. Methods and Findings Collective representation of the multi-source data facilitates the aggregation and harmonization of complex data elements. This enables joint modeling of the complete data, leading to the development of Big Data analytics, predictive synthesis, and statistical validation. Using heterogeneous PPMI data, we developed a comprehensive protocol for end-to-end data characterization, manipulation, processing, cleaning, analysis and validation. Specifically, we (i) introduce methods for rebalancing imbalanced cohorts, (ii) utilize a wide spectrum of classification methods to generate consistent and powerful phenotypic predictions, and (iii) generate reproducible machine-learning based classification that enables the reporting of model parameters and diagnostic forecasting based on new data. We evaluated several

  16. "It's a complex mesh"- how large-scale health system reorganisation affected the delivery of the immunisation programme in England: a qualitative study.

    Science.gov (United States)

    Chantler, Tracey; Lwembe, Saumu; Saliba, Vanessa; Raj, Thara; Mays, Nicholas; Ramsay, Mary; Mounier-Jack, Sandra

    2016-09-15

    The English health system experienced a large-scale reorganisation in April 2013. A national tri-partite delivery framework involving the Department of Health, NHS England and Public Health England was agreed and a new local operational model applied. Evidence about how health system re-organisations affect constituent public health programmes is sparse and focused on low and middle income countries. We conducted an in-depth analysis of how the English immunisation programme adapted to the April 2013 health system reorganisation, and what facilitated or hindered the delivery of immunisation services in this context. A qualitative case study methodology involving interviews and observations at national and local level was applied. Three sites were selected to represent different localities, varying levels of immunisation coverage and a range of changes in governance. Study participants included 19 national decision-makers and 56 local implementers. Two rounds of interviews and observations (immunisation board/committee meetings) occurred between December 2014 and June 2015, and September and December 2015. Interviews were audio recorded and transcribed verbatim and written accounts of observed events compiled. Data was imported into NVIVO 10 and analysed thematically. The new immunisation programme in the new health system was described as fragmented, and significant effort was expended to regroup. National tripartite arrangements required joint working and accountability; a shift from the simpler hierarchical pre-reform structure, typical of many public health programmes. New local inter-organisational arrangements resulted in ambiguity about organisational responsibilities and hindered data-sharing. Whilst making immunisation managers responsible for larger areas supported equitable resource distribution and strengthened service commissioning, it also reduced their ability to apply clinical expertise, support and evaluate immunisation providers' performance

  17. Intercomparison of terrain-following coordinate transformation and immersed boundary methods in large-eddy simulation of wind fields over complex terrain

    Science.gov (United States)

    Fang, Jiannong; Porté-Agel, Fernando

    2016-09-01

    Accurate modeling of complex terrain, especially steep terrain, in the simulation of wind fields remains a challenge. It is well known that the terrain-following coordinate transformation method (TFCT) generally used in atmospheric flow simulations is restricted to non-steep terrain with slope angles less than 45 degrees. Due to the advantage of keeping the basic computational grids and numerical schemes unchanged, the immersed boundary method (IBM) has been widely implemented in various numerical codes to handle arbitrary domain geometry including steep terrain. However, IBM could introduce considerable implementation errors in wall modeling through various interpolations because an immersed boundary is generally not co-located with a grid line. In this paper, we perform an intercomparison of TFCT and IBM in large-eddy simulation of a turbulent wind field over a three-dimensional (3D) hill for the purpose of evaluating the implementation errors in IBM. The slopes of the three-dimensional hill are not steep and, therefore, TFCT can be applied. Since TFCT is free from interpolation-induced implementation errors in wall modeling, its results can serve as a reference for the evaluation so that the influence of errors from wall models themselves can be excluded. For TFCT, a new algorithm for solving the pressure Poisson equation in the transformed coordinate system is proposed and first validated for a laminar flow over periodic two-dimensional hills by comparing with a benchmark solution. For the turbulent flow over the 3D hill, the wind-tunnel measurements used for validation contain both vertical and horizontal profiles of mean velocities and variances, thus allowing an in-depth comparison of the numerical models. In this case, TFCT is expected to be preferable to IBM. This is confirmed by the presented results of comparison. It is shown that the implementation errors in IBM lead to large discrepancies between the results obtained by TFCT and IBM near the surface

  18. Large Igneous Provinces of the Central Asia: data on geochronology, geochemistry and petrology of the Tien Shan and Junggar basaltic complexes

    Science.gov (United States)

    Simonov, V.; Mikolaichuk, A.

    2012-04-01

    During last years Large Igneous Provinces of the Central Asia were an object of steadfast attention of researchers. It was established that on a formation and development of continental earth crust a great influence was rendered by deep magmatic systems of mantle plumes of various age. Undoubtedly that these global processes of basaltic magmatism had in many respects crucial importance for ecology, climate and life development. Our researches of magmatic associations of the Tien Shan and Junggar have allowed to accumulate a considerable volume of new data on geochronology, geochemistry and physico-chemical parameters of petrogenesis of within-plate basaltic complexes of the Central Asia, which area of distribution covers territory over than 285000 km2. Analysis with the help of 40Ar/39Ar method has shown that the basaltic complexes of the Tien Shan have Cretaceous-Paleogene age (61-76 Ma). Basalts of the Southeast Kazakhstan (North Tien Shan) corresponds to Paleozoic age: 305-312 Ma. Rather close values of 40Ar/39Ar data are received for basalts of the Altynemel Ridge (South Junggar) - 282 Ma. Isotope 40Ar/39Ar dating of basalts of the Alakol site (Junggar) has shown Mesozoic age (186-198 Ma). As a whole, the carried out researches testify to formation of Tien Shan and Junggar within-plate basalt complexes as a result of influence of three plumes, operating in various time: Tarim (282-312 Ma), Junggar (186-198 Ma) and Tien Shan (61-76 Ma). Data on petrochemistry, geochemistry of trace and rare-earth elements and mineralogy shows an enriched plume characteristics (close to OIB) of Mesozoic-Cenozoic basalts and presence of group of Paleozoic rocks close to continental and oceanic plateau basalts. As a whole, successive evolution in time of geodynamics of within-plate basalt magmatism of Tien Shan and Junggar is established. Paleozoic - plateau basaltic magmatism like Siberian traps or oceanic plateau basalts of Ontong Java. Mesozoic - development of more local hot

  19. Facies analysis of an ancient, dismembered, large caldera complex and implications for intra-arc subsidence: Middle Jurassic strata of Cobre Ridge, southern Arizona, USA

    Science.gov (United States)

    Riggs, Nancy R.; Busby-Spera, Cathy J.

    1991-11-01

    The Middle Jurassic (˜ 170 Ma) Cobre Ridge caldera is an elongate caldera complex that formed during the eruption of the tuff of Pajarito, a crystal-rich rhyodacite ignimbrite with an estimated volume > 1000 km 3. The caldera subsided in two subequal blocks: to the southeast, caldera-forming ignimbrite is as much as 3000 m thick, whereas the northwest half of the caldera subsided to lesser depths during the initial eruption, but was the locus of subsidence during subsequent eruptions, providing a depocenter for a > 1.5 km-thick section of secondary- and post-collapse volcanic and sedimentary strata. These strata record moat formation and filling and waning volcanism, including: (1) areally restricted ignimbrites up to several tens of meters thick that may have been ponded between caldera margins and/or fault scarps; (2) a ⩾ 600 m-thick ignimbrite whose eruption probably caused further collapse of the caldera or enlargement of the caldera margins; (3) a localized debris apron deposit up to 500 m thick that represents material reworked from intra-caldera pyroclastic deposits and possibly caldera walls; and (4) eolian and fluvial sandstones and water-lain tuffs. Megabreccia blocks as large as 0.5 km along strike probably demarcate approximate caldera margins, suggesting that the composite caldera was approximately 50 km long by 25 km wide. The preserved thickness of the strata of Cobre Ridge ( > 4500 m) is greater than many ancient continental volcanic sequences, suggesting external (i.e. tectonic) controls on subsidence, but preservation of this great thickness of strata is apparently due entirely to volcanic subsidence.

  20. A large-scale complex haploinsufficiency-based genetic interaction screen in Candida albicans: analysis of the RAM network during morphogenesis.

    Directory of Open Access Journals (Sweden)

    Nike Bharucha

    2011-04-01

    Full Text Available The morphogenetic transition between yeast and filamentous forms of the human fungal pathogen Candida albicans is regulated by a variety of signaling pathways. How these pathways interact to orchestrate morphogenesis, however, has not been as well characterized. To address this question and to identify genes that interact with the Regulation of Ace2 and Morphogenesis (RAM pathway during filamentation, we report the first large-scale genetic interaction screen in C. albicans.Our strategy for this screen was based on the concept of complex haploinsufficiency (CHI. A heterozygous mutant of CBK1(cbk1Δ/CBK1, a key RAM pathway protein kinase, was subjected to transposon-mediated, insertional mutagenesis. The resulting double heterozygous mutants (6,528 independent strains were screened for decreased filamentation on SpiderMedium (SM. From the 441 mutants showing altered filamentation, 139 transposon insertion sites were sequenced,yielding 41 unique CBK1-interacting genes. This gene set was enriched in transcriptional targets of Ace2 and, strikingly, the cAMP-dependent protein kinase A (PKA pathway, suggesting an interaction between these two pathways. Further analysis indicates that the RAM and PKA pathways co-regulate a common set of genes during morphogenesis and that hyperactivation of the PKA pathway may compensate for loss of RAM pathway function. Our data also indicate that the PKA–regulated transcription factor Efg1 primarily localizes to yeast phase cells while the RAM–pathway regulated transcription factor Ace2 localizes to daughter nuclei of filamentous cells, suggesting that Efg1 and Ace2 regulate a common set of genes at separate stages of morphogenesis. Taken together, our observations indicate that CHI–based screening is a useful approach to genetic interaction analysis in C. albicans and support a model in which these two pathways regulate a common set of genes at different stages of filamentation.