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Sample records for laminadores tandem baseado

  1. Nanodispositivos baseados em grafeno

    OpenAIRE

    José Eduardo Padilha de Sousa

    2012-01-01

    Nesta tese investigamos a partir de cálculos de primeiros princípios, dispositivos e componentes de dispositivos baseados em grafeno. Abordamos os campos da nanoeletrônica e da spintrônica. Dentro da nanoeletrônica investigamos: (i) propriedades de transporte de um nanotransistor de bicamada de grafeno na presença de um gate duplo. Demonstramos que sobre a ação de um campo elétrico externo, mesmo utilizando um gate da ordem de 10 nm, à temperatura ambiente e 4.5K uma corrente nula nunca é exi...

  2. TANDEM

    Data.gov (United States)

    Federal Laboratory Consortium — The Tandem Van de Graaff facility provides researchers with beams of more than 40 different types of ions - atoms that have been stripped of their electrons. One of...

  3. Oxidación óptima de alambrones de acero de bajo carbono, durante el enfriamiento a la salida de un laminador de barras

    Directory of Open Access Journals (Sweden)

    Camurri, C.

    2002-04-01

    Full Text Available The increasing environmental exigencies demand that the oxide removal of steel wire rod before drawing is carried out by mechanical means, replacing the traditional descaling, wich is polluting. In such sense the objective of the present work is to settle down the operational conditions during the cooling of low carbon steel wire rod of 5.5 mm in diameter in order to have a minimum increase in the amount of rod oxide, so that it is more easily removable by mechanical cleaning before drawing. An additional objective is to simulate by means of the explicit finite differences method the temperature distribution of these wire rod during cooling. A good correlation model-experience is obtained, with temperature differences that do not exceed 4 %. On the other hand it is found that slowing water cooling is results in an increase of the total oxide to values averaging 0.7 % in weight, as specified by the drawing industry.

    Las crecientes exigencias medioambientales exigen que la remoción de óxidos de los alambrones de acero para posterior trefilación se efectúe por medios mecánicos, reemplazando así el tradicional y contaminante decapado. En tal sentido, el objetivo del presente trabajo es determinar las condiciones operacionales en el enfriamiento a la salida del laminador de barras, tales que produzcan un pequeño aumento en la cantidad de óxido total en alambrones de acero de bajo carbono de 5,5 mm de diámetro, a valores óptimos que permitan una adecuada limpieza mecánica previa al trefilado. Adicionalmente, simular, mediante el método explícito de las diferencias finitas, la distribución de temperaturas de esos mismos alambrones, durante el enfriamiento. Se obtiene una buena correlación modelo-experiencia, con diferencias para la temperatura que no sobrepasan el 4 % entre ambos. Por otro lado, se encuentra que, retardando el enfriamiento con agua, se logra incrementar el óxido a los valores promedio exigidos del 0,7 % en peso.

  4. Detecção de componentes faciais baseado em modelos de cor e antropometria

    OpenAIRE

    Moreira, Juliano Lucas

    2010-01-01

    Existem diferentes situações em que a detecção de componentes faciais desempenha um papel importante, como por exemplo: no reconhecimento facial, interação humano computador, teleconferências, análise de expressões faciais e animação. Esta dissertação apresenta, primeiramente, uma revisão bibliográfica dos trabalhos referentes à detecção dos componentes faciais. Após, é exposto o modelo desenvolvido para a detecção de componentes faciais, sendo este baseado em modelos de cor e antropometria. ...

  5. Framework para Desenvolvimento de Jogos 3D Baseado na API O3D

    Directory of Open Access Journals (Sweden)

    Leandro Bezerra Rodrigues

    2015-07-01

    Full Text Available Este trabalho apresenta um estudo sobre as atuais tecnologias disponíveis para exibição de conteúdo multimídia 3D na internet. Entre as aplicações-chave nesse mercado estão os jogos eletrônicos on-line. O foco do trabalho foi analisar as tecnologias para desenvolvimento de jogos e propor um framework baseado nessa análise, específico para o desenvolvimento de jogos 3D para internet, o que facilitará o trabalho de tarefas rotineiras do desenvolvedor. Este trabalho foi dividido em três etapas: 1 estudo das etapas de desenvolvimento de jogos 3D; 2 análise das tecnologias de gráficos 3D para internet; 3 desenvolvimento de uma proposta de framework baseado na API O3D de gráficos 3D para internet, a partir dos conhecimentos adquiridos nas etapas anteriores.

  6. Sistema de Apoio à Decisão Baseado em Ontologias para Unidades de Dor Torácica

    OpenAIRE

    2006-01-01

    Este artigo apresenta uma proposta de um sistema de apoio à decisão para auxiliar os profissionais de saúde com atividades nas Unidades de Dor Torácica. O sistema foi desenvolvido baseado em regras e combina o uso de ontologias para facilitar a disseminação do conhecimento.

  7. Sistema de Apoio à Decisão Baseado em Ontologias para Unidades de Dor Torácica

    Directory of Open Access Journals (Sweden)

    Josimara Canestraro

    2006-12-01

    Full Text Available Este artigo apresenta uma proposta de um sistema de apoio à decisão para auxiliar os profissionais de saúde com atividades nas Unidades de Dor Torácica. O sistema foi desenvolvido baseado em regras e combina o uso de ontologias para facilitar a disseminação do conhecimento.

  8. Uma Aplicação Prática de Orçamento Baseado em Atividades

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    Almir Teles da Silva

    2009-12-01

    Full Text Available A concorrência entre empresas do mesmo segmento de mercado vem provocando mudanças no comportamento dos gestores. A necessidade de reduzir custos sem comprometer a melhoria contínua na qualidade dos produtos oferecidos tem sido o grande desafio para a avaliação e reformulação do seu modelo de gestão. O presente artigo tem como objetivo apresentar um Orçamento Baseado em Atividades, por meio de uma aplicação prática desenvolvida em uma empresa do ramo de atividade de fundição. Seu desenvolvimento está fundamentado nos conceitos básicos de Planejamento, Orçamento e Custeio Baseado em Atividades. Faz uma análise descritiva entre o modelo de orçamento tradicional ou por recursos e o Orçamento Baseado em Atividades, demonstrando que o segundo possibilita identificar onde e como os recursos serão aplicados dentro do processo produtivo, enquanto o primeiro apenas informa o volume de recursos consumidos em cada centro de custo ou unidade de negócio. Concluiu-se neste estudo que a utilização de ferramentas de gestão como Orçamento Baseado em Atividades apresenta-se como um instrumento que melhora a competitividade da empresa em custo e preço num mercado globalizado.

  9. Tandem mobile robot system

    Energy Technology Data Exchange (ETDEWEB)

    Buttz, James H. (Albuquerque, NM); Shirey, David L. (Albuquerque, NM); Hayward, David R. (Albuquerque, NM)

    2003-01-01

    A robotic vehicle system for terrain navigation mobility provides a way to climb stairs, cross crevices, and navigate across difficult terrain by coupling two or more mobile robots with a coupling device and controlling the robots cooperatively in tandem.

  10. Serious games baseados em realidade virtual para educação médica

    Directory of Open Access Journals (Sweden)

    Liliane dos Santos Machado

    Full Text Available A evolução tecnológica tem permitido utilizar novas abordagens no processo de ensino-aprendizagem. Os serious games se relacionam com uma categoria especial de jogos, voltados a conteúdos e finalidades específicos, nos quais o jogador utiliza seus conhecimentos para resolver problemas, conhecer novas problemáticas e treinar tarefas. Uma das tecnologias propícias à construção de serious games é a Realidade Virtual, que oferece ambientes computacionais tridimensionais com formas avançadas de interação capazes de prover maior motivação ao processo de aprendizagem. No contexto da educação médica, tais aplicações apresentam um nicho ainda pouco explorado, se observados sua relevância e impactos na sociedade. Este artigo apresenta os serious games baseados em Realidade Virtual como uma proposta para o ensino de conteúdos específicos da área médica. Para isso, categoriza-os e apresenta o que tem sido desenvolvido nos últimos anos, seus componentes, características de desenvolvimento e suas potencialidades como oportunidades de pesquisa, desenvolvimento e negócios.

  11. Bifacial tandem solar cells

    Energy Technology Data Exchange (ETDEWEB)

    Wojtczuk, Steven J.; Chiu, Philip T.; Zhang, Xuebing; Gagnon, Edward; Timmons, Michael

    2016-06-14

    A method of fabricating on a semiconductor substrate bifacial tandem solar cells with semiconductor subcells having a lower bandgap than the substrate bandgap on one side of the substrate and with subcells having a higher bandgap than the substrate on the other including, first, growing a lower bandgap subcell on one substrate side that uses only the same periodic table group V material in the dislocation-reducing grading layers and bottom subcells as is present in the substrate and after the initial growth is complete and then flipping the substrate and growing the higher bandgap subcells on the opposite substrate side which can be of different group V material.

  12. JAERI tandem-accelerator and tandem-booster

    Energy Technology Data Exchange (ETDEWEB)

    Yoshida, Tadashi [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    1998-03-01

    In 1982, aiming at the new development of atomic energy research, the tandem accelerator of Japan Atomic Energy Research Institute (JAERI) was installed. In fiscal year 1993, the superconducting boosters which can increase the ion energy by up to 4 times were added, and the research in the region below 1000 MeV became possible. Those are electrostatic type accelerators which are easy to be used especially in basic research field, and are useful for future research. The tandem accelerator has been operated while maintaining the first class performance as the accelerator for various kinds of heavy ion beam. It has the special shape among electrostatic type accelerators, and is excellent in the easiness of control and stability. The main particulars of the tandem accelerator are shown. As for the ion sources of the tandem accelerator, three cesium sputter type ion sources are installed on two high voltage stands. The kinds of the ions which can be accelerated are mainly negative ions. As the improvement, electron cyclotron resonance (ECR) ion sources are expected to be adopted. As for the tandem boosters, the 1/4 wavelength type resonance hollow cylinder was adopted. The constitution of the tandem boosters is explained. The way of utilizing the tandem accelerator system and the aim for hereafter are reported. (K.I.)

  13. JAERI tandem-accelerator and tandem-booster

    Energy Technology Data Exchange (ETDEWEB)

    Yoshida, Tadashi [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    1998-03-01

    In 1982, aiming at the new development of atomic energy research, the tandem accelerator of Japan Atomic Energy Research Institute (JAERI) was installed. In fiscal year 1993, the superconducting boosters which can increase the ion energy by up to 4 times were added, and the research in the region below 1000 MeV became possible. Those are electrostatic type accelerators which are easy to be used especially in basic research field, and are useful for future research. The tandem accelerator has been operated while maintaining the first class performance as the accelerator for various kinds of heavy ion beam. It has the special shape among electrostatic type accelerators, and is excellent in the easiness of control and stability. The main particulars of the tandem accelerator are shown. As for the ion sources of the tandem accelerator, three cesium sputter type ion sources are installed on two high voltage stands. The kinds of the ions which can be accelerated are mainly negative ions. As the improvement, electron cyclotron resonance (ECR) ion sources are expected to be adopted. As for the tandem boosters, the 1/4 wavelength type resonance hollow cylinder was adopted. The constitution of the tandem boosters is explained. The way of utilizing the tandem accelerator system and the aim for hereafter are reported. (K.I.)

  14. Modern tandem control systems

    Science.gov (United States)

    Lutz, J. R.; Marsaudon, J. C.

    1993-04-01

    Nowadays, tandem electrostatic accelerators can benefit greatly from the growing possibilities provided by modern control facilities. Controlling an electrostatic accelerator first requires the solution of technological problems raised by the necessity of fitting inside the tank equipment which is highly stressed by the physical environment. Then, these controls can take advantage of new techniques which appear on the market. Present computer technology provides cheap powerful workstations for efficient operator interfacing, and new modular and distributed control concepts have been developed for general use in experimental physics, in data acquisition and in control systems. The general trend towards standardization is now accepted for both hardware and software and this brings benefits to the designer and the user.

  15. Software baseado em regras fuzzy para avaliação de vitalidade da orquídea Catasetum Fimbriatum

    Directory of Open Access Journals (Sweden)

    Adriane Cavichiolli

    2016-03-01

    Full Text Available A Lógica Fuzzy estuda meios de raciocínio que são aproximados, ao contrário do raciocínio exato usado na lógica clássica. É utilizada no desenvolvimento de métodos e algoritmos de modelagem e controle de processos, possibilitando a redução da complexidade de projeto e implementação, visando solucionar problemas difíceis de serem tratados por técnicas clássicas. O desenvolvimento de sistemas inteligentes que sirvam de apoio à tomada de decisão na área das ciências agrárias tem despertado grande interesse dos produtores rurais. Assim, este trabalho tem como objetivo desenvolver um software baseado em regras fuzzy para auxiliar no manejo da espécie Catasetum Fimbriatum.

  16. Modelo teórico de sensores ópticos baseados em fibras com grade de Bragg

    OpenAIRE

    CUNHA, José Renato Ferreira Alves da

    2007-01-01

    Ao se aplicar uma tração exterior a uma fibra óptica, seu índice de refração pode modificar devido ao efeito foto-elástico. Quando a fibra contém uma grade de Bragg inscrita em seu núcleo, além do índice de refração seu período espacial também modifica, permitindo sua aplicação como sensores ópticos de temperatura e/ou deformação de alta sensitvidade. Do ponto de vista teórico, até o presente a operação de sensores baseados em fibras ópticas com grade de Brag (FGB) é explicada pelo efeito ...

  17. Agentes Peer-To-Peer Baseados Em Ontologias Como Mediadores Em Processos Comunitários De Partilha E Aprendizagem

    Directory of Open Access Journals (Sweden)

    G. A. Giménez-Lugo

    2009-06-01

    Full Text Available Este artigo tenta realçar a importância do desenvolvimento de sistemas voltados ao aprendizado baseados em agentes inteligentes estruturados como sistemas P2P (peer-to-peer – entre pares. Como parte deste esforço é apresentado um modelo no qual conceitos pertencentes a ontologias são estendidos com informação organizacional para representar de forma explícita as situações sociais nas quais foram aprendidas e utilizadas. Uma aplicação P2P usando o modelo é descrita. Parte-se de um modelo organizacional específico, MOISE+, brevemente apresentado. Uma ponte sócio-organizacional poderá agora auxiliar a interligar e reconciliar visões diferentes de conhecimento para facilitar o aprendizado coletivo.

  18. Construção de ambiente para desenvolvimento de jogos educacionais baseados em interface de gestos

    Directory of Open Access Journals (Sweden)

    João Roberto de T. Quadros

    2013-11-01

    Full Text Available Este artigo apresenta um projeto para construção de um ambiente de programação de jogos educacionais baseado em interface de gestos, realizado dentro de uma escola federal de informática. Este artigo enfatiza a parte do projeto voltada para montagem do ambiente por meio de equipamentos para captura de movimentos e de uma plataforma de programação didática para construção de aplicativos. O artigo também apresenta o desenvolvimento de protótipos visando o teste desse ambiente de modo a prepará-lo para que sejam desenvolvidos aplicativos mais complexos voltados para área educacional.

  19. Covalently linked tandem lesions in DNA.

    Science.gov (United States)

    Patrzyc, Helen B; Dawidzik, Jean B; Budzinski, Edwin E; Freund, Harold G; Wilton, John H; Box, Harold C

    2012-12-01

    Reactive oxygen species (ROS) generate a type of DNA damage called tandem lesions, two adjacent nucleotides both modified. A subcategory of tandem lesions consists of adjacent nucleotides linked by a covalent bond. Covalently linked tandem lesions generate highly characteristic liquid chromotography-tandem mass spectrometry (LC-MS/MS) elution profiles. We have used this property to comprehensively survey X-irradiated DNA for covalently linked tandem lesions. A total of 15 tandem lesions were detected in DNA irradiated in deoxygenated aqueous solution, five tandem lesions were detected in DNA that was irradiated in oxygenated solution.

  20. Tandem Van de Graaff facility

    Data.gov (United States)

    Federal Laboratory Consortium — Completed in 1970, the Tandem Van de Graaff facility was for many years the world's largest electrostatic accelerator facility. It can provide researchers with beams...

  1. Tandem Cylinder Noise Predictions

    Science.gov (United States)

    Lockhard, David P.; Khorrami, Mehdi R.; CHoudhari, Meelan M.; Hutcheson, Florence V.; Brooks, Thomas F.; Stead, Daniel J.

    2007-01-01

    In an effort to better understand landing-gear noise sources, we have been examining a simplified configuration that still maintains some of the salient features of landing-gear flow fields. In particular, tandem cylinders have been studied because they model a variety of component level interactions. The present effort is directed at the case of two identical cylinders spatially separated in the streamwise direction by 3.7 diameters. Experimental measurements from the Basic Aerodynamic Research Tunnel (BART) and Quiet Flow Facility (QFF) at NASA Langley Research Center (LaRC) have provided steady surface pressures, detailed off-surface measurements of the flow field using Particle Image Velocimetry (PIV), hot-wire measurements in the wake of the rear cylinder, unsteady surface pressure data, and the radiated noise. The experiments were conducted at a Reynolds number of 166 105 based on the cylinder diameter. A trip was used on the upstream cylinder to insure a fully turbulent shedding process and simulate the effects of a high Reynolds number flow. The parallel computational effort uses the three-dimensional Navier-Stokes solver CFL3D with a hybrid, zonal turbulence model that turns off the turbulence production term everywhere except in a narrow ring surrounding solid surfaces. The current calculations further explore the influence of the grid resolution and spanwise extent on the flow and associated radiated noise. Extensive comparisons with the experimental data are used to assess the ability of the computations to simulate the details of the flow. The results show that the pressure fluctuations on the upstream cylinder, caused by vortex shedding, are smaller than those generated on the downstream cylinder by wake interaction. Consequently, the downstream cylinder dominates the noise radiation, producing an overall directivity pattern that is similar to that of an isolated cylinder. Only calculations based on the full length of the model span were able to

  2. Combinando simulação e sistemas baseados em conhecimento para o projeto de sistemas avançados de manufatura Combining simulation and knowledge-based systems for advanced manufacturing system design

    Directory of Open Access Journals (Sweden)

    Denis Borenstein

    1998-08-01

    Full Text Available Este trabalho apresenta um sistema inteligente desenvolvido para verificar se uma determinada opção de projeto de um Sistema Avançado de Manufatura (SAM respeita os objetivos de projeto fixados pelo time de projetistas. Se um problema é encontrado, o sistema começa um ciclo de análise-diagnóstico-recomendação no sentido de diagnosticar a causa do problema, bem como, sugerir possíveis ações no sentido de melhorar a alternativa de projeto em relação ao objetivo não respeitado. Para que este ciclo seja realizado com sucesso, o sistema desenvolvido combina simulação e sistemas baseados em conhecimento, utilizando a experiência e o conhecimento adquiridos por especialistas durante prévios projetos de SAM. Um exemplo ilustra a eficácia do sistema computacional.This article describes a tandem knowledge-based system developed to verify whether a specific advanced manufacturing system (AMS scenario meets the design requirements defined by the design team. If a problem is found, the system starts an analysis-diagnosis-recommendation cycle in order to identify the possible cause(s of the design deficiency as well as to propose changes to improve the performance of the AMS scenario. For this cycle to be successful, the developed system combines simulation and knowledge-based systems, using the experience and knowledge acquired by specialists during previous AMS projects. A case study illustrates the effectiveness of the system.

  3. Association of number of tandem repeats in two important adhesins in Mycoplasma hyopneumoniae

    Directory of Open Access Journals (Sweden)

    L. F. dos Santos

    2015-10-01

    Full Text Available RESUMODiversidade genética de Mycoplasma hyopneumoniae tem sido relatada em análise múltipla de repetições em tandem em número variável (MLVA. O objetivo deste estudo foi descrever a distribuição espacial e a heterogeneidade genética de tipos de M. hyopneumoniae no Brasil, bem como investigar a correlação entre regiões de repetição 1 (RR1 e 3 (RR3 de duas adesinas importantes (P97 e P146. Foram identificados 39 tipos de MLVA baseados no número de repetições em tandem em P97 RR1 e RR3 P146. A correlação negativa significativa (Spearman's rho = -0,26; P = 0,022 entre P97 RR1 e RR3 P146 foi observada, o que sugere um possível mecanismo compensatório que permitiria a bactéria manter a sua capacidade de adesão. Os resultados contribuem para compreender a epidemiologia das M. hyopneumoniae no quarto maior país produtor de suínos do mundo.

  4. Integração do custeio baseado em atividades com a Teoria das Restrições.

    Directory of Open Access Journals (Sweden)

    Welington Rocha

    2006-06-01

    Full Text Available Neste trabalho os autores analisam um modelo de mensuração e de informação, integrando elementos do custeio baseado em atividades e da teoria das restrições, para dar suporte ao processo decisório das organizações. Inicialmente o trabalho resgata, do ponto de vista histórico, quando, como e por que foram criados o ABC e a TOC; em seguida, os dois são comparados, evidenciando-se suas diferenças e semelhanças. Como métodos e técnicas de pesquisa utilizam pesquisa bibliográfica, reflexão dialética com base nos textos selecionados e um exemplo numérico ilustrativo. Conclui-se que o ABC e a TOC são instrumentos gerenciais complementares, não incompatíveis, ao contrário do que afirmam Goldratt e outros estudiosos. O produto final do estudo representa uma contribuição científica para a teoria e a prática em Administração na medida em que destrói o mito da incompatibilidade daqueles dois conceitos e oferece aos acadêmicos e aos profissionais uma nova alternativa de relatório gerencial.

  5. AGRUPAMENTO DE FUNCIONÁRIOS BASEADO NO BIG FIVE MODEL EM UM PROJETO DE FRANQUIA DE ACADEMIAS

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    Michel Anzanello

    2016-12-01

    Full Text Available O aumento da concorrência especificamente no setor de serviços faz com que as empresas procurem melhores práticas gerenciais. Nesse contexto, técnicas de clusterização vêm ganhando espaço para identificar ações que se adequem melhor aos perfis dos colaboradores. Além disso, técnicas da Psicologia Pessoal, especialmente a área de análise de personalidade tem ampla aplicação em estudos e empresas. O presente artigo aborda a clusterização por k-means e Fuzzy C-Means, avaliados através do Silhouette Index (SI, além da análise de componentes principais das amostras em uma loja de um projeto de franquia de academia. As amostras foram caracterizadas tanto por características sócio-demográficas e sua relação com a empresa, bem como seus escores nos testes de personalidade baseados no FFM. Os resultados indicam a formação dois grupos que se diferenciam especialmente em idade, tempo de empresa, salário e cargo, além de acompanhar os maiores escores no FFM. Os clusters formados foram analisados gerencialmente, possibilitando a proposição de ações para cada grupo.

  6. Financiamento e diversidade produtiva: um modelo baseado em agentes com flutuações cíclicas emergentes

    Directory of Open Access Journals (Sweden)

    Teófilo Henrique Pereira de Paula

    2013-04-01

    Full Text Available As abordagens que consideram os choques externos como causa principal das flutuações econômicas têm dominado o debate sobre o tema. De fato, a ideia de que instabilidades podem se originar endogenamente sempre esbarrou em dificuldades de formalização ao pressupor a existência de processos não lineares e cumulativos como intrínsecos ao sistema econômico. Recentemente, a utilização de ferramentas computacionais tem permitido a superação de muitos desses obstáculos. Nessa perspectiva, o presente trabalho tem como objetivo analisar o comportamento agregado de um sistema econômico caracterizado pela interação entre unidades individuais heterogêneas que tomam decisões de forma descentralizada em um ambiente incerto. A metodologia utilizada se baseia na construção e na implementação computacional de um modelo de simulação baseado em agentes (agent-based model. Particularmente, uma estrutura industrial com diferenciação assimétrica de produtos é conectada a um sistema financeiro por meio do mercado de crédito. Dentre os principais resultados, crises financeiras com características bastante próximas daquelas descritas por Minsky emergem da evolução do sistema.

  7. Asymmetric tandem organic solar cells

    Science.gov (United States)

    Howells, Thomas J.

    Organic photovoltaics (OPVs) is an area that has attracted much attention recently as a potential low cost, sustainable source of energy with a good potential for full-scale commercialisation. Understanding the factors that determine the efficiency of such cells is therefore a high priority, as well as developing ways to boost efficiency to commercially-useful levels. In addition to an intensive search for new materials, significant effort has been spent on ways to squeeze more performance out of existing materials, such as multijunction cells. This thesis investigates double junction tandem cells in the context of small molecule organic materials. . Two different organic electron donor materials, boron subphthalocyanine chloride (SubPc) and aluminium phthalocyanine chloride (ClAlPc) were used as donors in heterojunctions with C60 to create tandem cells for this thesis. These materials have been previously used for solar cells and the absorption spectra of the donor materials complement each other, making them good candidates for tandem cell architectures. The design of the recombination layer between the cells is considered first, with silver nanoparticles demonstrated to work well as recombination centres for charges from the front and back sub-cells, necessary to avoid a charge build-up at the interface. The growth conditions for the nanoparticles are optimised, with the tandem cells outperforming the single heterojunction architecture. Optical modelling is considered as a method to improve the understanding of thin film solar cells, where interference effects from the reflective aluminium electrode are important in determining the magnitude of absorption a cell can achieve. The use of such modelling is first demonstrated in hybrid solar cells based on a SubPc donor with a titanium oxide (TiOx) acceptor; this system is ideal for observing the effects of interference as only the SubPc layer has significant absorption. The modelling is then applied to tandem cells

  8. Índice de desagregação do solo baseado em energia ultra-sônica

    Directory of Open Access Journals (Sweden)

    M. A. Carolino de Sá

    1999-09-01

    Full Text Available A estabilidade de agregados tem sido determinada por meio de peneiramento úmido, impacto de gotas e, mais recentemente, sonificação. O objetivo deste trabalho foi propor um índice baseado em níveis de energia ultra-sônica para expressar a estabilidade de agregados, utilizando material de horizontes A e B de Latossolo Roxo e Terra Roxa Estruturada. Agregados de 4,76 a 7,93 mm foram submetidos a níveis crescentes de energia ultra-sônica. O índice de dispersão (massa de agregados secos e, ou, partículas < 0,053 mm/massa inicial de agregados foi plotado em função da energia correspondente para dispersão de cada amostra. As curvas de dispersão foram linearizadas, dividindo-se a energia pelo índice de dispersão, obtendo-se uma equação do tipo EA/ID = a + bEA. O índice de desagregação foi obtido, dividindo-se os termos b/a da equação, tendo como unidade mL J-1. Quanto menor o índice de desagregação, maior a estabilidade de agregados, principalmente para amostras dos horizontes A de ambos os solos. A vantagem desse índice sobre um único nível de energia ou mesmo o diâmetro médio geométrico se deve ao fato de ele considerar toda a faixa de energia empregada na curva de dispersão.

  9. A study of reflex tandem accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Nakajima, Takao; Morinobu, Shunpei; Gono, Yasuyuki; Sagara, Kenji; Sugimitsu, Tsuyoshi; Mitarai, Shiro; Nakamura, Hiroyuki; Ikeda, Nobuo; Morikawa, Tsuneyasu [Kyushu Univ., Fukuoka (Japan). Faculty of Science

    1996-12-01

    An investigation on `developing research theme and its realizing experimental apparatus` based on the tandem accelerator facility is executed. At a standpoint of recognition on essentiality of preparation, improvement or novel technical development capable of extreme increase in capacity of the tandem accelerator facility to form COE with high uniqueness, proposal of numerous ideas and their investigations and searches were conducted. In this paper, consideration results of `beam reacceleration using tandem accelerator` were shown as follows: (1) Short life unstable nuclei formed by nuclear reaction using tandem acceleration primary beam is ionized to negative and to reaccelerate by using the same tandem accelerator. And (2) by combination of plural electrons with the tandem primary accelerated beam, numbers of charge is reduced to reaccelerate by the tandem. (G.K.)

  10. MR-Tandem: parallel X!Tandem using Hadoop MapReduce on Amazon Web Services.

    Science.gov (United States)

    Pratt, Brian; Howbert, J Jeffry; Tasman, Natalie I; Nilsson, Erik J

    2012-01-01

    MR-Tandem adapts the popular X!Tandem peptide search engine to work with Hadoop MapReduce for reliable parallel execution of large searches. MR-Tandem runs on any Hadoop cluster but offers special support for Amazon Web Services for creating inexpensive on-demand Hadoop clusters, enabling search volumes that might not otherwise be feasible with the compute resources a researcher has at hand. MR-Tandem is designed to drop in wherever X!Tandem is already in use and requires no modification to existing X!Tandem parameter files, and only minimal modification to X!Tandem-based workflows. MR-Tandem is implemented as a lightly modified X!Tandem C++ executable and a Python script that drives Hadoop clusters including Amazon Web Services (AWS) Elastic Map Reduce (EMR), using the modified X!Tandem program as a Hadoop Streaming mapper and reducer. The modified X!Tandem C++ source code is Artistic licensed, supports pluggable scoring, and is available as part of the Sashimi project at http://sashimi.svn.sourceforge.net/viewvc/sashimi/trunk/trans_proteomic_pipeline/extern/xtandem/. The MR-Tandem Python script is Apache licensed and available as part of the Insilicos Cloud Army project at http://ica.svn.sourceforge.net/viewvc/ica/trunk/mr-tandem/. Full documentation and a windows installer that configures MR-Tandem, Python and all necessary packages are available at this same URL. brian.pratt@insilicos.com

  11. Nanocrystal assembly for tandem catalysis

    Science.gov (United States)

    Yang, Peidong; Somorjai, Gabor; Yamada, Yusuke; Tsung, Chia-Kuang; Huang, Wenyu

    2014-10-14

    The present invention provides a nanocrystal tandem catalyst comprising at least two metal-metal oxide interfaces for the catalysis of sequential reactions. One embodiment utilizes a nanocrystal bilayer structure formed by assembling sub-10 nm platinum and cerium oxide nanocube monolayers on a silica substrate. The two distinct metal-metal oxide interfaces, CeO.sub.2--Pt and Pt--SiO.sub.2, can be used to catalyze two distinct sequential reactions. The CeO.sub.2--Pt interface catalyzed methanol decomposition to produce CO and H.sub.2, which were then subsequently used for ethylene hydroformylation catalyzed by the nearby Pt--SiO.sub.2 interface. Consequently, propanal was selectively produced on this nanocrystal bilayer tandem catalyst.

  12. "Nanocrystal bilayer for tandem catalysis"

    Energy Technology Data Exchange (ETDEWEB)

    Yamada, Yusuke; Tsung, Chia Kuang; Huang, Wenyu; Huo, Ziyang; E.Habas, Susan E; Soejima, Tetsuro; Aliaga, Cesar E; Samorjai, Gabor A; Yang, Peidong

    2011-01-24

    Supported catalysts are widely used in industry and can be optimized by tuning the composition and interface of the metal nanoparticles and oxide supports. Rational design of metal-metal oxide interfaces in nanostructured catalysts is critical to achieve better reaction activities and selectivities. We introduce here a new class of nanocrystal tandem catalysts that have multiple metal-metal oxide interfaces for the catalysis of sequential reactions. We utilized a nanocrystal bilayer structure formed by assembling platinum and cerium oxide nanocube monolayers of less than 10 nm on a silica substrate. The two distinct metal-metal oxide interfaces, CeO2-Pt and Pt-SiO2, can be used to catalyse two distinct sequential reactions. The CeO2-Pt interface catalysed methanol decomposition to produce CO and H2, which were subsequently used for ethylene hydroformylation catalysed by the nearby Pt-SiO2 interface. Consequently, propanal was produced selectively from methanol and ethylene on the nanocrystal bilayer tandem catalyst. This new concept of nanocrystal tandem catalysis represents a powerful approach towards designing high-performance, multifunctional nanostructured catalysts

  13. Nanocrystal bilayer for tandem catalysis.

    Science.gov (United States)

    Yamada, Yusuke; Tsung, Chia-Kuang; Huang, Wenyu; Huo, Ziyang; Habas, Susan E; Soejima, Tetsuro; Aliaga, Cesar E; Somorjai, Gabor A; Yang, Peidong

    2011-05-01

    Supported catalysts are widely used in industry and can be optimized by tuning the composition and interface of the metal nanoparticles and oxide supports. Rational design of metal-metal oxide interfaces in nanostructured catalysts is critical to achieve better reaction activities and selectivities. We introduce here a new class of nanocrystal tandem catalysts that have multiple metal-metal oxide interfaces for the catalysis of sequential reactions. We utilized a nanocrystal bilayer structure formed by assembling platinum and cerium oxide nanocube monolayers of less than 10 nm on a silica substrate. The two distinct metal-metal oxide interfaces, CeO(2)-Pt and Pt-SiO(2), can be used to catalyse two distinct sequential reactions. The CeO(2)-Pt interface catalysed methanol decomposition to produce CO and H(2), which were subsequently used for ethylene hydroformylation catalysed by the nearby Pt-SiO(2) interface. Consequently, propanal was produced selectively from methanol and ethylene on the nanocrystal bilayer tandem catalyst. This new concept of nanocrystal tandem catalysis represents a powerful approach towards designing high-performance, multifunctional nanostructured catalysts.

  14. Short Tandem Repeat DNA Internet Database

    Science.gov (United States)

    SRD 130 Short Tandem Repeat DNA Internet Database (Web, free access)   Short Tandem Repeat DNA Internet Database is intended to benefit research and application of short tandem repeat DNA markers for human identity testing. Facts and sequence information on each STR system, population data, commonly used multiplex STR systems, PCR primers and conditions, and a review of various technologies for analysis of STR alleles have been included.

  15. Desenvolvimento de um sistema de transmissão mecânica baseado em engrenagens cônicas e faciais

    OpenAIRE

    Kleber Eduardo Bianchi

    2009-01-01

    O presente trabalho foi desenvolvido com o intuito de propor um sistema de transmissão mecânica baseado em engrenagens cônicas e faciais, de razões de velocidades escalonadas, para uso industrial e no setor da mobilidade. Em virtude do grande desenvolvimento das transmissões compostas por engrenagens faciais nos últimos anos, implementado por centros de pesquisa da área e por indústrias do setor aeronáutico, um dos objetivos deste trabalho foi estender o campo de aplicação dessas engrenagens ...

  16. Proposta de um sistema de gestão de estresse para médicos em hospitais baseado na OHSAS

    OpenAIRE

    Santos, Cidalia de Lourdes de Moura

    2008-01-01

    Esta pesquisa teve por objetivo o desenvolvimento de um modelo de gestão de estresse para médicos em hospitais baseado nas diretrizes propostas pela OHSAS 18001:2007. Com o advento da globalização e da competitividade, o trabalho tornouse mais estressante e as doenças decorrentes do estresse se fizeram mais presentes. O estresse é uma reação fisiológica do corpo, portanto, necessária à vida. O estresse quando em equilíbrio traz benefícios para o indivíduo e é chamado de eust...

  17. Um sistema baseado em conhecimento para configuração e supervisão de algoritmos de controle adaptativo

    OpenAIRE

    Ruben Mario Nazzaretta

    1991-01-01

    Resumo: O presente trabalho detalha o desenvolvimento de um sistema baseado em conhecimento para o auxílio nas tarefas de configuração e supervisão de algoritmos de modelagem e controle de processos. O sistema consta dos seguintes módulos: Módulo de controle onde encontram-se os algoritmos de controle, de três termos (PID), de Variância Mínima Generalizada (GMV) e o Controlador Preditivo Generalizado (GPC); Módulo de identificação com o algoritmo de matriz estendida; Módulo de detecção de não...

  18. Materiais nanoestruturados e filmes finos baseados em TiO2 para aplicação em fotocatálise

    OpenAIRE

    Sajjad Ullah

    2014-01-01

    O objetivo desta Tese é preparar e caracterizar nanopartículas de TiO2 e SiO2@ TiO2 e obter filmes finos baseados nesses materiais nanoestruturados usando a metodologia de preparação de filmes conhecida como layer-by-layer (LbL). Primeiramente, TiO2 amorfo sintetizado a partir de sulfato de titanila (TiOSO4) foi cristalizado por método de tratamento hidrotérmico brando (HTT). O efeito da temperatura e tempo de tratamento hidrotérmico na cristalinidade, tamanho de partícula e fotoatividade de ...

  19. O aprendizado baseado em gestão como práxis e a gamification como ferramenta para o desenvolvimento de competências gerenciais

    OpenAIRE

    2016-01-01

    A utilização excessiva de metodologias tradicionais de ensino, que foca na transferência de conhecimento, nos cursos relacionados às ciências administrativas apresenta-se como a principal problemática deste trabalho que tem como objetivo avaliar os resultados educacionais decorrentes da aplicação de uma nova proposta pedagógica denominada de metodologia do Aprendizado Baseado em Gestão como Práxis (ABGP), a partir de uma disciplina na graduação em administração. A primeira etapa deste estudo ...

  20. A aprendizagem em um programa tematico de lingua estrangeira (inglês) baseado em tarefas em contextos de quinta serie do ensino fundamental

    OpenAIRE

    Rosely Perez Xavier

    1999-01-01

    Resumo: Esta pesquisa tem como objetivo implementar e avaliar um programa temático baseado em tarefas que foi elaborado para duas 5a. séries do Ensino Fundamental. O processo de aprendizagem é interpretado e avaliado com base nas mudanças pedagógicas realizadas pelas professoras no programa planejado, nas manifestações discursivas e comportamentais demonstradas pelos alunos durante as interações, aqui denominadas de sintomas positivos e negativos de aprendizagem, nas atitudes dos alunos com r...

  1. Sistema de coordenação de ordens de produção baseado na estratégia bata de manufatura

    OpenAIRE

    Vinícius Soares Del Bianco

    2008-01-01

    O presente trabalho apresenta uma proposta de implantação de um Sistema de Coordenação de Ordens (SCO) baseado na Estratégia Bata de Manufatura (EBM). O intuito deste trabalho é verificar a interferência e eficácia deste sistema nas atividades de PCP de uma fábrica de processamento de termoplásticos. O referencial teórico deste trabalho é fundamentado na EBM, nos SCO e nos Sistemas de Medição de Desempenho (SMD). Foi utilizado o método de pesquisa-ação como recurso para se dete...

  2. Uma ferramenta de manipulação de pacotes para análise de protocolos de redes industriais baseados em TCP/IP

    OpenAIRE

    Kobayashi, Tiago Hiroshi

    2009-01-01

    Neste trabalho é apresentada uma ferramenta de manipulação de pacotes destinada à realização de testes em dispositivos que implementam protocolos de comunicação baseados em TCP/IP utilizados em redes industriais. A ferramenta foi desenvolvida em linguagem de programação Python, como uma extensão ao Scapy. Esta ferramenta, denominada IndPM - Industrial Packet Manipulator, permite testar os dispositivos presentes em redes industriais em relação a possíveis vulnerabilidades, realizar teste...

  3. Aplicação do custeio baseado em atividades : estudo de caso em um laboratório de análises clínicas

    OpenAIRE

    Struett, Mirian Aparecida Micarelli; Souza, Antônio Artur de; Raimundini, Simone Letícia

    2007-01-01

    As organizações hospitalares brasileiras estão num estágio ainda incipiente quanto ao uso de ferramentas de gestão. Nesse cenário, as informações de custos tornam-se imprescindíveis à tomada de decisão, no que se refere à sua gestão financeira e operacional. O custeio baseado em atividades é um exemplo dessas ferramentas. Há poucas publicações que descrevem pesquisas sobre o uso desse método de custeio em hospitais. Não há, entretanto, nenhum relato na literatura de hospitais brasileiros que ...

  4. Tandem mirror technology demonstration facility

    Energy Technology Data Exchange (ETDEWEB)

    1983-10-01

    This report describes a facility for generating engineering data on the nuclear technologies needed to build an engineering test reactor (ETR). The facility, based on a tandem mirror operating in the Kelley mode, could be used to produce a high neutron flux (1.4 MW/M/sup 2/) on an 8-m/sup 2/ test area for testing fusion blankets. Runs of more than 100 h, with an average availability of 30%, would produce a fluence of 5 mW/yr/m/sup 2/ and give the necessary experience for successful operation of an ETR.

  5. Modelagem de um sistema para apoio à tomada de decisão com uso de técnicas de raciocínio baseado em casos

    Directory of Open Access Journals (Sweden)

    Liane Mahlmann Kipper

    2014-06-01

    Full Text Available Este artigo apresenta o processo de desenvolvimento de um sistema de gestão do conhecimento para apoio à tomada de decisões percorrendo os temas que abordam o conhecimento, seu capital intelectual, as estratégias utilizadas nas empresas e o uso de um sistema que utiliza técnicas de raciocínio baseado em casos. A Inteligência Artificial através da técnica de Raciocínio Baseado em Casos (RBC foi utilizada atendendo o desafio da Empresa de tornar o conhecimento parte da sua cultura. A proposta desenvolvida foi aplicada no setor comercial da Empresa. Esta ação proporcionou à empresa análises detalhadas dos resultados, auxiliando os gestores na tomada das decisões estratégicas. Três ferramentas foram criadas e adaptadas, para tornar esta aplicação possível e diferenciada, que são: linear da faixa de interesse para cada atributo, elaboração de uma matriz simétrica de similaridade e tabela de definição dos valores por atributos. Isto possibilitou melhoria significativa na acurácia das informações em tempo real, auxiliando na tomada de decisões e gerando resultados eficazes.

  6. O uso do custeio baseado em atividades: ABC (Activity Based Costing nas maiores empresas de Santa Catarina

    Directory of Open Access Journals (Sweden)

    Ilse Maria Beuren

    2002-12-01

    Full Text Available Devido à globalização da economia, as empresas evoluíram para a produção de enormes variedades de produtos personalizados. Com o intuito de atender às exigências dos clientes, surgiu a necessidade de grandes alterações nos processos tecnológicos. Como conseqüência, os custos indiretos passaram a ser mais significativos, o que implicou um novo método de distribuição desses custos, capaz de distribuir melhor os custos indiretos aos produtos e serviços. A esse método foi dado o nome de custeio baseado em atividades - ABC (Activity Based Costing. Esse método foi investigado por Carlos Yorghi Khoury em 1996, numa pesquisa aplicada às 500 maiores empresas do Brasil. O objetivo deste trabalho foi replicar essa pesquisa nas maiores empresas catarinenses, a fim de observar se esses resultados obtidos assemelham-se aos obtidos na pesquisa com as empresas catarinenses.Nesta pesquisa, dos 200 questionários enviados para as maiores empresas de Santa Catarina, 81 retornaram com as questões respondidas. O trabalho levou a conclusões importantes, como: as empresas de Santa Catarina têm amplo conhecimento do sistema ABC; algumas empresas que implantaram esse sistema já estão desistindo de seu uso, em função da complexidade para apropriar os custos indiretos e as despesas às atividades e estas aos produtos.Due to the economic globalization, enterprises have started to produce enormous varieties of personalized products. In order to attend to the requirements of their clients, huge changes in the technological process were needed. Consequently, indirect costs became more significant, which led to a new method for distributing the indirect costs, capable of better distributing the indirect costs of products and services.This method was called Activity Based Costing and was investigated by Carlos Yorghi Khoury in 1996 through a research applied in the 500 biggest companies in Brazil. This paper aims to replicate the 1996 research in the

  7. Device operation of organic tandem solar cells

    NARCIS (Netherlands)

    Hadipour, A.; de Boer, B.; Blom, P. W. M.

    2008-01-01

    A generalized methodology is developed to obtain the current-voltage characteristic of polymer tandem solar cells by knowing the electrical performance of both sub cells. We demonstrate that the electrical characteristics of polymer tandem solar cells are correctly predicted for both the series and

  8. Packet models revisited: tandem and priority systems

    NARCIS (Netherlands)

    Mandjes, M.R.H.

    2004-01-01

    We examine two extensions of traditional single-node packet-scale queueing models: tandem networks and (strict) priority systems. Two generic input processes are considered: periodic and Poisson arrivals. For the two-node tandem, an exact expression is derived for the joint distribution of the total

  9. Packet models revisited: tandem and priority systems

    NARCIS (Netherlands)

    M.R.H. Mandjes

    2004-01-01

    Abstract : We examine two extensions of traditional single-node packet-scale queueing models: tandem networks and (strict) priority systems. Two generic input processes are considered: periodic and Poisson arrivals. For the two-node tandem, an exact expression is derived for the joint distribution o

  10. Device operation of organic tandem solar cells

    NARCIS (Netherlands)

    Hadipour, A.; de Boer, B.; Blom, P. W. M.

    2008-01-01

    A generalized methodology is developed to obtain the current-voltage characteristic of polymer tandem solar cells by knowing the electrical performance of both sub cells. We demonstrate that the electrical characteristics of polymer tandem solar cells are correctly predicted for both the series and

  11. Detecting long tandem duplications in genomic sequences

    Directory of Open Access Journals (Sweden)

    Audemard Eric

    2012-05-01

    Full Text Available Abstract Background Detecting duplication segments within completely sequenced genomes provides valuable information to address genome evolution and in particular the important question of the emergence of novel functions. The usual approach to gene duplication detection, based on all-pairs protein gene comparisons, provides only a restricted view of duplication. Results In this paper, we introduce ReD Tandem, a software using a flow based chaining algorithm targeted at detecting tandem duplication arrays of moderate to longer length regions, with possibly locally weak similarities, directly at the DNA level. On the A. thaliana genome, using a reference set of tandem duplicated genes built using TAIR,a we show that ReD Tandem is able to predict a large fraction of recently duplicated genes (dS  Conclusions ReD Tandem allows to identify large tandem duplications without any annotation, leading to agnostic identification of tandem duplications. This approach nicely complements the usual protein gene based which ignores duplications involving non coding regions. It is however inherently restricted to relatively recent duplications. By recovering otherwise ignored events, ReD Tandem gives a more comprehensive view of existing evolutionary processes and may also allow to improve existing annotations.

  12. Tandem Catalysis Utilizing Olefin Metathesis Reactions.

    Science.gov (United States)

    Zieliński, Grzegorz K; Grela, Karol

    2016-07-01

    Since olefin metathesis transformation has become a favored synthetic tool in organic synthesis, more and more distinct non-metathetical reactions of alkylidene ruthenium complexes have been developed. Depending on the conditions applied, the same olefin metathesis catalysts can efficiently promote isomerization reactions, hydrogenation of C=C double bonds, oxidation reactions, and many others. Importantly, these transformations can be carried out in tandem with olefin metathesis reactions. Through addition of one portion of a catalyst, a tandem process provides structurally advanced products from relatively simple substrates without the need for isolation of the intermediates. These aspects not only make tandem catalysis very attractive from a practical point of view, but also open new avenues in (retro)synthetic planning. However, in the literature, the term "tandem process" is sometimes used improperly to describe other types of multi-reaction sequences. In this Concept, a number of examples of tandem catalysis involving olefin metathesis are discussed with an emphasis on their synthetic value.

  13. Status of JAERI tandem accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Yoshida, Tadashi; Kanda, Susumu; Takeuchi, Suehiro [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment] (and others)

    2001-02-01

    JAERI Tandem Accelerator had been operated approximately 230 days in fiscal year of 1999. Meanwhile, we had three times of maintenance period with vent. Total operation-times were 5273 hours. We could not carry out the experiment using rare gas, due to malfunction of the RF power supply for the ECR ion source. The type of the RF power supply is peculiar and it is impossible to get spare parts for repair. We are now investigating the backup RF power supply. The power supply for the magnet became unstable due to degradation of insulation in the shunt resistance, which is used for feedback stabilization. Stability was recovered after cleaning. The acrylic resin shaft was cracked. This cracks have a potential for severe accidents. So far bearing of the shaft has no problem. The reason of cracks may be self-destruction by charge accumulation in the shaft. JAERI Tandem Accelerator is approximately 20 years old. There appear requirements on the higher ion currents for additional ion species. Therefore, authors are investigating cost effective improvement plans of RFQ (Radio Frequency Quadra-pole) and IH type accelerator based on KEK (High Energy Accelerator Research Organization) R and D. As a whole, maintenance services for the control system are increasing due to some changes of computer programs. There are some difficulties to keep skilled personnel for facilities operation. Authors are gradually increasing hired personnel with contract from 1993. However, loads for JAERI permanent staffs are still heavy. It takes much longer time to educate skilled persons especially for safety. (Y. Tanaka)

  14. Monitoramento não invasivo baseado na biorreatância revela instabilidade hemodinâmica significativa durante cesárea eletiva sob raquianestesia

    Directory of Open Access Journals (Sweden)

    Anne Doherty

    2011-06-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: O monitoramento da pressão arterial oferece uma compreensão limitada das consequências hemodinâmicas da raquianestesia para cesariana. O objetivo deste estudo foi avaliar, com o auxílio do monitor de débito cardíaco não invasivo baseado na biorreatância, as alterações hemodinâmicas durante cesariana eletiva sob raquianestesia, na qual doses intermitentes de fenilefrina foram utilizados para prevenir e tratar a hipotensão. MÉTODOS: Este estudo observacional foi realizado após aprovação da comissão de ética na pesquisa e assinatura do consentimento informado. Pacientes saudáveis marcadas para cesariana eletiva sob raquianestesia foram avaliadas. Doses intermitentes de fenilefrina foram administrados para manter a pressão arterial sistólica nos níveis basais e as pacientes foram avaliadas com o monitor de débito cardíaco não invasivo baseado na biorreatância. Os dados hemodinâmicos foram colhidos continuamente no momento basal e durante os períodos pós-raquianestesia e pós-nascimento do feto. Os dados foram analisados usando ANOVA para modelos mistos e um p < 0,05 foi considerado significativo. RESULTADOS: A pressão arterial sistólica foi mantida entre 79,2% ± 14,2 e 105,9% ± 10,0 dos valores basais durante o período pós-raquianestesia e 78,4% ± 11,13 e 100,9% ± 10,7 dos valores basais no período pós-nascimento do feto (média ± DP. Flutuações significativas foram observadas na pressão arterial sistólica, frequência cardíaca e débito cardíaco no período pós-nascimento. CONCLUSÕES: Um novo monitor não invasivo, baseado na biorreatância, revelou flutuações hemodinâmicas significativas durante a cesariana sob raquianestesia, a despeito das tentativas de manter a pressão arterial nos níveis basais com doses intermitentes de fenilefrina.

  15. Lab-scale periphyton-based system for fish culture Sistema laboratorial baseado em perifíton para piscicultura

    Directory of Open Access Journals (Sweden)

    Davi de Holanda Cavalcante

    2011-12-01

    Full Text Available The present research aimed to assess a lab-scale model to study periphyton-based systems for fish culture. Twenty-five liters plastic aquaria were stocked with three Nile tilapia, Oreochromis niloticus, juveniles (0.77±0.09g; 12 fish m-2 for 6 weeks in a 2x2 factorial design. Small plastic bottles were placed in some aquaria for periphyton development. Two feeding regimes were employed: "full-fed" (standard feeding rates were fully adopted and "half-fed" (50% of standard feeding rates. Growth performance and limnological variables were observed in each aquarium. There werefive replicates per treatment. Fish have fed actively on periphyton, especially in the half-fed aquaria. The placement of periphyton bottles had no significant effects on the water quality variables, except by the gross primary productivity which became lower. Half-fed aquaria presented lower concentrations of ammonia (0.28-0.29mg L-1, nitrite (0.33-0.37mg L-1 and phosphorus (0.42-0.43mg L-1 than full-fed aquaria (0.57-0.60mg L-1; 0.75-0.77mg L-1; 0.67-0.70mg L-1, respectively. The final body weight of fish in half-fed aquaria with periphyton bottles (6.22±0.64g was significantly higher than in aquaria without bottles (4.65±0.36g. Although the growth rate of fish was lower in the half-fed aquaria (4.27-4.72 vs. 5.29-5.61% BW day-1, survival was significantly higher when compared to the full-fed aquaria (93.3-100.0 vs. 80.0-83.4%. Only in the aquaria with periphyton the feed conversation ratio was improved by the feeding restriction regime.O presente trabalho teve como objetivo avaliar um modelo laboratorial para estudo de sistemas de cultivo de peixes baseados em perifíton. Aquários de 25L foram estocados com três juvenis de tilápia do Nilo, Oreochromis niloticus (0,77±0,09g; 12 peixes m-2 por seis semanas, em arranjo fatorial 2x2. Pequenas garrafas plásticas foram colocadas em determinados aquários para o desenvolvimento de perifíton. Dois regimes alimentares foram

  16. Tandem Mirror Reactor Systems Code (Version I)

    Energy Technology Data Exchange (ETDEWEB)

    Reid, R.L.; Finn, P.A.; Gohar, M.Y.; Barrett, R.J.; Gorker, G.E.; Spampinaton, P.T.; Bulmer, R.H.; Dorn, D.W.; Perkins, L.J.; Ghose, S.

    1985-09-01

    A computer code was developed to model a Tandem Mirror Reactor. Ths is the first Tandem Mirror Reactor model to couple, in detail, the highly linked physics, magnetics, and neutronic analysis into a single code. This report describes the code architecture, provides a summary description of the modules comprising the code, and includes an example execution of the Tandem Mirror Reactor Systems Code. Results from this code for two sensitivity studies are also included. These studies are: (1) to determine the impact of center cell plasma radius, length, and ion temperature on reactor cost and performance at constant fusion power; and (2) to determine the impact of reactor power level on cost.

  17. Monitoramento de tráfego aéreo baseado em padrões de trajetórias de aeronaves

    OpenAIRE

    Ronald Annoni Junior

    2012-01-01

    Este trabalho tem como objetivo principal propor um método, baseado em técnicas de aprendizagem de máquina, para a detecção de trajetórias anômalas em relação a um conjunto de trajetórias, com vista à aplicação em monitoramento de tráfego aéreo. Dadas as características do tráfego aéreo (regulamentação, economia, segurança) existe uma certa regularidade nas trajetórias das aeronaves de tal forma que o seu comportamento conjunto pode ser modelado e eventuais desvios desse modelo podem ser dete...

  18. Seleção de instâncias baseado em aprendizado de métricas para K Vizinhos Mais Próximos

    OpenAIRE

    Max, Eduardo Zárate Guerreiro

    2016-01-01

    A seleção de instâncias, em apredizado de máquina, procura identificar instâncias relevantes e remover as instâncias que são redundantes ou prejudiciais do conjunto original. Classificadores baseados em instâncias, como o K Vizinhos Mais Próximos (k-NN), são fortemente beneficiados com esta seleção, podendo prover uma classificação mais rápida, uma diminuição nos requisitos de armazenamento e uma diminuição na sensibilidade ao ruído. Um fundamento essencial a esses algoritmo...

  19. Retificadores trifásicos com fator de potência unitário baseados nos transformadores trifásicos/bifásicos

    OpenAIRE

    Badin, Alceu André

    2009-01-01

    Tese (doutorado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia Elétrica. Este trabalho apresenta o estudo dos retificadores de tensão trifásicos isolados em baixa freqüência, com fator de potência unitário e regulação das tensões de saída, baseados nos transformadores trifásicos/bifásicos. Trata-se de conversores que transferem energia de uma fonte CA trifásica para uma fonte CC, fazendo circular na fonte CA uma corrente senoidal de a...

  20. OTIMIZAÇÃO USANDO ALGORITMO GENÉTICO DE UM MODELO DE PROPAGÇÃO BASEADO EM EQUAÇÕES PARABÓLICAS

    Directory of Open Access Journals (Sweden)

    Antonio Carlos Vilanova

    2013-01-01

    Full Text Available Este artigo apresenta uma avaliação metodológica para otimizar parâmetros em um conhecido modelo de propagação de ondas de rádio na troposfera. O modelo de propagação é baseado no Divisor de passos de Fourier para resolver equações parabólicas. Nossa abordagem utiliza algoritmo genético para determinar os valores dos parâmetros que maximize a intensidade de campo em uma determinada posição do observador. Usando algoritmo genético o tempo necessário na busca dos parâmetros ótimos é reduzido significativamente. A avaliação preliminar dos resultados através da simulação mostra que a nossa abordagem é promissora.

  1. Pesquisa em arte por ocasião dos doutorados baseados na prática. Um estudo do caso da Universidade de Paris 1 Sorbonne

    Directory of Open Access Journals (Sweden)

    Bernard Darras

    Full Text Available Em várias instituições acadêmicas coloca-se a questão de abrir a pesquisa em mestrado e doutorado a outras abordagens, além dos dispositivos científicos clássicos do PhD ou do doutorado de especialidade. O que está em pauta, portanto, são os doutorados profissionais e aqueles baseados na prática. Um dos primeiros exemplos nesse campo foi desenvolvido no Reino Unido, com os doutorados baseados na prática em artes criativas e cênicas e em design [Practice-based Doctorates in the Creative and Performing Arts and Design]. Após essa experiência, pelo mundo todo pergunta-se sobre a natureza desses doutorados, que poderiam eventualmente não mais necessitar da elaboração de uma tese redigida para acompanhar o artefato inventado ou criado. Neste artigo, tratarei essas questões com base em uma abordagem crítica do sistema doutoral posto em prática na Sorbonne desde os anos 1970. A partir da história dos candidatos e da história das instituições, questionarei os dispositivos científicos e artísticos implantados e as limitações e problemas gerados. A primeira parte deste artigo é dedicada aos processos de condicionamento axiológico dos estudantes. A segunda parte, ao processo de artificação de suas práticas; e a terceira, ao debate sobre os problemas epistemológicos da pesquisa em arte, confrontada com a pesquisa científica e com os problemas encontrados pelos doutorandos. Ao final, são abordados os instrumentos e métodos trazidos pelas ciências humanas e sociais.

  2. Tutoria em leitura e escrita baseado no modelo de RTI – resposta à intervenção em crianças com dislexia do desenvolvimento

    Directory of Open Access Journals (Sweden)

    Andréa Carla Machado

    2014-08-01

    Full Text Available Objetivo analisar e comparar o desempenho em tarefas de leitura e escrita em crianças com dislexia do desenvolvimento após tutoria baseado no modelo de resposta à intervenção. Métodos participaram deste estudo 15 crianças com o diagnóstico interdisciplinar de dislexia do desenvolvimento de 2º ao 6º ano do ensino fundamental da rede pública municipal da cidade de Marília-SP, com faixa etária de oito a 12 anos de idade, de ambos os sexos, sendo 75% do sexo masculino, divididos em Grupo I – grupo experimental (sete crianças que receberam intervenção e Grupo II – grupo controle (oito crianças não receberam a intervenção, os mesmos foram pareados segundo sexo e faixa etária com o Grupo I. As crianças foram submetidas ao levantamento diagnóstico de Leitura e Escrita e ao programa de intervenção em tutoria baseado no Modelo de Resposta à Intervenção . Os resultados foram analisados estatisticamente por meio do teste de Wilcoxon e Teste de Kruskal-Wallis para verificar possíveis diferenças de desempenho nas tarefas entre os grupos estudados. Resultados os resultados revelaram diferença estatisticamente significante entre o Grupo I e o Grupo II, onde as crianças com dislexia do Grupo I apresentaram desempenho superior na tarefade leitura de palavras e leitura do livro I em relação às crianças do Grupo II. Conclusão grupo I apresentou avanços significantes comparados à Grupo II, que não recebeu intervenção de tutoria.

  3. Custeio Baseado em Atividades (ABC Aplicado ao Setor Público: Estudo de Caso no Colégio Militar do Rio de Janeiro (CMRJ

    Directory of Open Access Journals (Sweden)

    Luis Paulo Faria Carmo, Lino Martins Silva

    2011-04-01

    Full Text Available O objetivo desta pesquisa foi verificar se o método de Custeio Baseado em Atividades (ABC é adequado para ser aplicado na mensuração dos custos educacionais no Colégio Militar do Rio de Janeiro. Embora a Lei federal nº. 4.320/64 já determinasse a necessidade de apuração dos custos, ingressos e resultados, a Administração Pública ainda não sabe quanto custa cada uma de suas atividades. A relevância do tema deriva da necessidade de as Organizações Públicas de permitir o acompanhamento e a avaliação de sua gestão. Porém, o Sistema Integrado de Administração Financeira do Governo Federal (SIAFI, principal ferramenta do governo, não evidencia em suas contas o custo de cada atividade. A metodologia utilizada teve como “principal finalidade desenvolver, esclarecer e modificar idéias a fim de fornecer hipótese pesquisável para estudos posteriores” (Tripodi, Fellin e Meyer, 1981, p.64 e como fontes de pesquisa a revisão bibliográfica e a análise documental, sendo utilizado como estratégia metodológica de um estudo de caso real no Colégio Militar do Rio de Janeiro (CMRJ. A análise dos resultados aponta ser adequada a aplicação do método de Custeio Baseado em Atividades (ABC para evidenciação dos custos das atividades educacionais, bem como subsidiar a avaliação da qualidade do gasto Público.

  4. Inverted 3J Tandem Thermophotovoltaic Modules Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Spire Semiconductor proposes to make an InGaAs-based three-junction (3J) tandem thermophotovoltaic (TPV) cell to utilize more of the blackbody spectrum (from a GPHS)...

  5. Large deviations for tandem queueing systems

    Directory of Open Access Journals (Sweden)

    Roland L. Dobrushin

    1994-01-01

    Full Text Available The crude asymptotics of the large delay probability in a tandem queueing system is considered. The main result states that one of the two channels in the tandem system defines the crude asymptotics. The constant that determines the crude asymptotics is given. The results obtained are based on the large deviation principle for random processes with independent increments on an infinite interval recently established by the authors.

  6. Tandemly Arrayed Genes in Vertebrate Genomes

    Directory of Open Access Journals (Sweden)

    Deng Pan

    2008-01-01

    Full Text Available Tandemly arrayed genes (TAGs are duplicated genes that are linked as neighbors on a chromosome, many of which have important physiological and biochemical functions. Here we performed a survey of these genes in 11 available vertebrate genomes. TAGs account for an average of about 14% of all genes in these vertebrate genomes, and about 25% of all duplications. The majority of TAGs (72–94% have parallel transcription orientation (i.e., they are encoded on the same strand in contrast to the genome, which has about 50% of its genes in parallel transcription orientation. The majority of tandem arrays have only two members. In all species, the proportion of genes that belong to TAGs tends to be higher in large gene families than in small ones; together with our recent finding that tandem duplication played a more important role than retroposition in large families, this fact suggests that among all types of duplication mechanisms, tandem duplication is the predominant mechanism of duplication, especially in large families. Finally, several species have a higher proportion of large tandem arrays that are species-specific than random expectation.

  7. The combinatorics of tandem duplication trees.

    Science.gov (United States)

    Gascuel, Olivier; Hendy, Michael D; Jean-Marie, Alain; McLachlan, Robert

    2003-02-01

    We developed a recurrence relation that counts the number of tandem duplication trees (either rooted or unrooted) that are consistent with a set of n tandemly repeated sequences generated under the standard unequal recombination (or crossover) model of tandem duplications. The number of rooted duplication trees is exactly twice the number of unrooted trees, which means that on average only two positions for a root on a duplication tree are possible. Using the recurrence, we tabulated these numbers for small values of n. We also developed an asymptotic formula that for large n provides estimates for these numbers. These numbers give a priori probabilities for phylogenies of the repeated sequences to be duplication trees. This work extends earlier studies where exhaustive counts of the numbers for small n were obtained. One application showed the significance of finding that most maximum-parsimony trees constructed from repeat sequences from human immunoglobins and T-cell receptors were tandem duplication trees. Those findings provided strong support to the proposed mechanisms of tandem gene duplication. The recurrence relation also suggests efficient algorithms to recognize duplication trees and to generate random duplication trees for simulation. We present a linear-time recognition algorithm.

  8. Implantacao de protocolo de reducao de sedacao profunda baseado em analgesia comprovadamente seguro e factivel em pacientes submetidos a ventilacao mecanica

    Directory of Open Access Journals (Sweden)

    Guillermo Bugedo

    2013-09-01

    Full Text Available INTRODUÇÃO: A sedação profunda em pacientes gravemente enfermos se associa a uma maior duração da ventilação mecânica e à permanência mais longa na unidade de terapia intensiva. Diversos protocolos foram utilizados para melhorar esses desfechos. Implantamos e avaliamos um protocolo de sedação baseado em analgesia, direcionado por objetivos e cuidado por enfermeiros, em pacientes gravemente enfermos submetidos à ventilação mecânica. MÉTODOS: Realizamos um estudo multicêntrico prospectivo em duas fases (antes e depois, que envolveu 13 unidades de terapia intensiva localizadas no Chile. Após uma fase observacional (grupo observacional, N=155, delineamos, implantamos e avaliamos um protocolo de sedação cuidado por enfermeiros, direcionado por objetivos (grupo de intervenção, N=132 para tratar pacientes que necessitaram de ventilação mecânica por mais do que 48 horas. O parâmetro primário de avaliação foi a obtenção de dias livres de ventilador até o dia 28. RESULTADOS: No grupo de intervenção, a proporção de pacientes com sedação profunda ou coma diminuiu de 55,2 para 44,0%. A incidência de agitação não se alterou entre os períodos, permanecendo em cerca de 7%. Dias livres de ventilador até o dia 28, permanência na unidade de terapia intensiva e mortalidade foram similares em ambos os grupos. Após 1 ano, a presença de sintomas de desordem de estresse pós-traumático nos sobreviventes foi similar entre os grupos. CONCLUSÕES: Delineamos e implantamos no Chile um protocolo de sedação baseado em analgesia, direcionado por objetivos e cuidado por enfermeiros. Embora não se tenha observado melhora nos principais desfechos, observamos que o presente protocolo foi seguro e factível, e que resultou em períodos mais curtos de sedação profunda, sem aumento da agitação.

  9. Tandem transformation of glycerol to esters.

    Science.gov (United States)

    Sotenko, Maria V; Rebroš, Martin; Sans, Victor S; Loponov, Konstantin N; Davidson, Matthew G; Stephens, Gill; Lapkin, Alexei A

    2012-12-31

    Tandem transformation of glycerol via microbial fermentation and enzymatic esterification is presented. The reaction can be performed with purified waste glycerol from biodiesel production in a continuous mode, combining continuous fermentation with membrane-supported enzymatic esterification. Continuous anaerobic fermentation was optimized resulting in the productivity of 2.4 g L⁻¹ h⁻¹ of 1,3-propanediol. Biphasic esterification of 1,3-propanediol was optimized to achieve ester yield of up to 75%. A hollow fibre membrane contactor with immobilized Rhizomucor miehei lipase was demonstrated for the continuous tandem fermentation-esterification process.

  10. RedFace: um sistema de reconhecimento facial baseado em técnicas de análise de componentes principais e autofaces

    Directory of Open Access Journals (Sweden)

    Fabio Abrantes Diniz

    2013-05-01

    Full Text Available Desenvolver um modelo computacional de reconhecimento facial não é uma tarefa trivial, porque as faces e os estímulos visuais multidimensionais possuem características de modelagem complexa. A grande dificuldade está na modelagem de uma face que abstraia as características que as diferenciem de outras faces, já que estas apresentam poucas diferenças substanciais entre si. Embora diferentes, todas as faces possuem características como, por exemplo, uma boca, dois olhos e um nariz. No presente trabalho é proposto um sistema de reconhecimento facial desenvolvido em duas fases. Inicialmente utilizam-se as técnicas de Análise de Componentes Principais (PCA e Eigenfaces (autofaces para a extração de características da face. Na segunda fase foram aplicados os classificadores K-Nearest Neighbors (K-NN, Random Forest (Floresta Aleatória e K-Star (K-estrela no processo de reconhecimento da face. A validação dos algoritmos foi realizada numa base de dados contendo 1280 imagens de 64 classes distintas. Finalmente, foi mostrado que o desempenho dos algoritmos testados para sistemas de reconhecimentos de face baseado em PCA foram muito satisfatórios, atingindo as melhores taxas de reconhecimento, acima de 90% em todos os classificadores.

  11. Heidegger: o estudo dos fenômenos humanos baseados na existência humana como ser-aí (Dasein

    Directory of Open Access Journals (Sweden)

    Ida Elizabeth Cardinalli

    2015-08-01

    Full Text Available O presente artigo pretende esclarecer a posição crítica do filósofo Martin Heidegger, explicitada no livro Seminários de Zollikon, em relação à transposição do método da ciência natural moderna para o estudo dos fenômenos humanos e apresentar sua proposição de um método mais pertinente ao estudo da existência humana. O autor propõe indicações de um método baseado na compreensão do existir humano como "ser-aí" e "ser-no-mundo" e também nos existenciais descritos em Ser e tempo, tais como espacialidade, temporalidade, ser-com-o-outro e corporeidade. Ao mesmo tempo, destaca que os fenômenos humanos não deveriam ser submetidos e circunscritos às descrições ontológicas dos existenciais, quando o método visa ao esclarecimento das experiências específicas e singulares de cada ser humano.

  12. 14 CFR 105.45 - Use of tandem parachute systems.

    Science.gov (United States)

    2010-01-01

    ... completed a tandem instructor course given by the manufacturer of the tandem parachute system used in the... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Use of tandem parachute systems. 105.45... (CONTINUED) AIR TRAFFIC AND GENERAL OPERATING RULES PARACHUTE OPERATIONS Parachute Equipment and Packing...

  13. Evolution of the tandem mirror reactor concept

    Energy Technology Data Exchange (ETDEWEB)

    Carlson, G.A.; Logan, B.G.

    1982-03-09

    We discuss the evolution of the tandem mirror reactor concept from the original conceptual reactor design (1977) through the first application of the thermal barrier concept to a reactor design (1979) to the beginning of the Mirror Advanced Reactor Study (1982).

  14. M/G/∞ tandem queues

    NARCIS (Netherlands)

    Boxma, O.J.

    1984-01-01

    We consider a series of queues with Poisson input. Each queueing system contains an infinite number of service channels. The service times in each channel have a general distribution. For this M/G∞ tandem model we obtain the joint time-dependent distribution of queue length and residual service tim

  15. M/G/∞ tandem queues

    NARCIS (Netherlands)

    Boxma, O.J.

    1984-01-01

    We consider a series of queues with Poisson input. Each queueing system contains an infinite number of service channels. The service times in each channel have a general distribution. For this M/G∞ tandem model we obtain the joint time-dependent distribution of queue length and residual service tim

  16. Modelling of tandem cell temperature coefficients

    Energy Technology Data Exchange (ETDEWEB)

    Friedman, D.J. [National Renewable Energy Lab., Golden, CO (United States)

    1996-05-01

    This paper discusses the temperature dependence of the basic solar-cell operating parameters for a GaInP/GaAs series-connected two-terminal tandem cell. The effects of series resistance and of different incident solar spectra are also discussed.

  17. The PSI/ETH tandem accelerator facility

    Energy Technology Data Exchange (ETDEWEB)

    Synal, H.A.; Doebeli, M.; Fuhrmann, H.; Kubik, P.W.; Nebiker, P.W. [Paul Scherrer Inst. (PSI), Villigen (Switzerland)] [and others

    1997-09-01

    The 1996 operation of the PSI/ETH tandem accelerator at ETH Hoenggerberg is summarised with a detailed compilation of the beam time statistics and the statistics of AMS samples for the different radioisotopes and for the major fields of research. (author) 2 tab.

  18. Evolution of orthologous tandemly arrayed gene clusters

    Directory of Open Access Journals (Sweden)

    Bertrand Denis

    2011-10-01

    Full Text Available Abstract Background Tandemly Arrayed Gene (TAG clusters are groups of paralogous genes that are found adjacent on a chromosome. TAGs represent an important repertoire of genes in eukaryotes. In addition to tandem duplication events, TAG clusters are affected during their evolution by other mechanisms, such as inversion and deletion events, that affect the order and orientation of genes. The DILTAG algorithm developed in 1 makes it possible to infer a set of optimal evolutionary histories explaining the evolution of a single TAG cluster, from an ancestral single gene, through tandem duplications (simple or multiple, direct or inverted, deletions and inversion events. Results We present a general methodology, which is an extension of DILTAG, for the study of the evolutionary history of a set of orthologous TAG clusters in multiple species. In addition to the speciation events reflected by the phylogenetic tree of the considered species, the evolutionary events that are taken into account are simple or multiple tandem duplications, direct or inverted, simple or multiple deletions, and inversions. We analysed the performance of our algorithm on simulated data sets and we applied it to the protocadherin gene clusters of human, chimpanzee, mouse and rat. Conclusions Our results obtained on simulated data sets showed a good performance in inferring the total number and size distribution of duplication events. A limitation of the algorithm is however in dealing with multiple gene deletions, as the algorithm is highly exponential in this case, and becomes quickly intractable.

  19. Optimal (batch) dispatching in a tandem queue

    NARCIS (Netherlands)

    D. van Leeuwen (Daphne); R. Núñez Queija (Rudesindo (Sindo))

    2016-01-01

    textabstractMotivated by various applications in logistics, road traffic and production management, we investigate two versions of a tandem queueing model in which the service rate of the first queue can be controlled. The objective is to keep the mean number of jobs in the second queue as low as po

  20. Tandem queue with server slow-down

    NARCIS (Netherlands)

    D.I. Miretskiy; W.R.W. Scheinhardt; M.R.H. Mandjes

    2007-01-01

    We study how rare events happen in the standard two-node tandem Jackson queue and in a generalization, the socalled slow-down network, see [2]. In the latter model the service rate of the first server depends on the number of jobs in the second queue: the first server slows down if the amount of job

  1. MJIT - Manutenção por Just in Time: manutenção otimizante realizada no tempo exato baseado em condições operacionais

    Directory of Open Access Journals (Sweden)

    Michitoshi Oishi

    1997-06-01

    Full Text Available O presente artigo investigou como as fábricas japonesas desenvolvem sua manutenção para redução das paradas de produção. Isto aumenta a qualidade e produtividade, evitando atraso na entrega dos produtos e satisfazendo as necessidades dos clientes. Além do TPM-Total Productive Maintenance, existe outro sistema de manutenção baseado nas condições operacionais do equipamento, realizando a manutenção no momento necessário, que pode ser chamado de MJ1T-Manutenção Por Jus In Time. Este sistema evita a manutenção baseada na estimativa de vida útil do equipamento que pode realizar a manutenção antes do momento necessário, como depois da quebra. Uma pesquisa qualitativa realizada em fábricas brasileiras, identificou o alto potencial e necessidade de implantação de um sistema de manutenção similar ao MJIT.This article investigated how Japanese factorys develop their maintenance to reduce productions pauses. It increases productivity and quality, avoides products late delivery and satisfies customers needs. Besides TPM-Total Productive Maintenance, there is another maintenance system based on equipment operational conditions doing the maintenance in the exact moment of necessity that can be called MJIT-Maintenance by Just In Time. It avoids unnecessary maintenance based on the estimated life time that may conduct to realize maintenance before the real necessity or after broken. A qualitative research in brasilian factorys identified a high potential and need of a mainenance system similar to MJIT.

  2. O desenvolvimento da compreensão oral e em leitura em um programa temático baseado em tarefas

    Directory of Open Access Journals (Sweden)

    Rosely Perez Xavier

    2004-01-01

    Full Text Available Este trabalho discute o desenvolvimento das habilidades de compreensão oral e escrita em língua inglesa a partir da implementação de um programa temático de ensino baseado em tarefas em duas 5as séries do ensino fundamental. Os dados foram coletados através de diários, gravações de aulas em áudio e vídeo, questionários e testes de rendimento em dois momentos do processo de implementação, de modo que os resultados pudessem ser comparados entre si. Para verificar se os ganhos de aprendizagem haviam sido significativos, duas 6as séries realizaram os mesmos testes de compreensão oral e em leitura e os seus resultados foram comparados com aqueles dos sujeitos desta pesquisa. Nos contextos pesquisados, os alunos apresentaram ganhos de aprendizagem, sendo eles mais significativos na habilidade de compreensão oral.This paper discusses the development of both listening and reading skills of two groups of Brazilian secondary students learning English under a task-based thematic syllabus. The data were collected through weekly exchanged lesson diaries, audio- and videotaped sets of lessons, questionnaires, and achievement tests in two moments of the syllabus implementation so that the results could be compared. Aiming at investigating the students' learning gains in both reading and listening comprehension, two next-level groups of Brazilian secondary students were asked to carry out the same achievement tests and their results were compared to the ones achieved by the subjects. The results of this research show that the subjects had learning gains in listening more than in reading.

  3. Mechanically stacked concentrator tandem solar cells

    Science.gov (United States)

    Andreev, V. M.; Rumyantsev, V. D.; Karlina, L. B.; Kazantsev, A. B.; Khvostikov, V. P.; Shvarts, M. Z.; Sorokina, S. V.

    1995-01-01

    Four-terminal mechanically stacked solar cells were developed for advanced space arrays with line-focus reflective concentrators. The top cells are based on AlGaAs/GaAs multilayer heterostructures prepared by low temperature liquid phase epitaxy. The bottom cells are based on heteroepitaxial InP/InGaAs liquid phase epitaxy or on homo-junction GaSb, Zn-diffused structures. The sum of the highest reached efficiencies of the top and bottom cells is 29.4 percent. The best four-terminal tandems have an efficiency of 27 to 28 percent. Solar cells were irradiated with 1 MeV electrons and their performances were determined as a function of fluence up to 10(exp 16) cm(exp-2). It was shown that the radiation resistance of developed tandem cells is similar to the most radiative stable AlGaAs/GaAs cells with a thin p-GaAs photoactive layer.

  4. Cold Climate Heat Pumps Using Tandem Compressors

    Energy Technology Data Exchange (ETDEWEB)

    Shen, Bo [ORNL; Abdelaziz, Omar [ORNL; Rice, C Keith [ORNL; Baxter, Van D [ORNL

    2016-01-01

    In cold climate zones, e.g. ASHRAE climate regions IV and V, conventional electric air-source heat pumps (ASHP) do not work well, due to high compressor discharge temperatures, large pressure ratios and inadequate heating capacities at low ambient temperatures. Consequently, significant use of auxiliary strip heating is required to meet the building heating load. We introduce innovative ASHP technologies as part of continuing efforts to eliminate auxiliary strip heat use and maximize heating COP with acceptable cost-effectiveness and reliability. These innovative ASHP were developed using tandem compressors, which are capable of augmenting heating capacity at low temperatures and maintain superior part-load operation efficiency at moderate temperatures. Two options of tandem compressors were studied; the first employs two identical, single-speed compressors, and the second employs two identical, vapor-injection compressors. The investigations were based on system modeling and laboratory evaluation. Both designs have successfully met the performance criteria. Laboratory evaluation showed that the tandem, single-speed compressor ASHP system is able to achieve heating COP = 4.2 at 47 F (8.3 C), COP = 2.9 at 17 F (-8.3 C), and 76% rated capacity and COP = 1.9 at -13 F (-25 C). This yields a HSPF = 11.0 (per AHRI 210/240). The tandem, vapor-injection ASHP is able to reach heating COP = 4.4 at 47 F, COP = 3.1 at 17 F, and 88% rated capacity and COP = 2.0 at -13 F. This yields a HSPF = 12.0. The system modeling and further laboratory evaluation are presented in the paper.

  5. TandEM: Titan and Enceladus mission

    Science.gov (United States)

    Coustenis, A.; Atreya, S.K.; Balint, T.; Brown, R.H.; Dougherty, M.K.; Ferri, F.; Fulchignoni, M.; Gautier, D.; Gowen, R.A.; Griffith, C.A.; Gurvits, L.I.; Jaumann, R.; Langevin, Y.; Leese, M.R.; Lunine, J.I.; McKay, C.P.; Moussas, X.; Muller-Wodarg, I.; Neubauer, F.; Owen, T.C.; Raulin, F.; Sittler, E.C.; Sohl, F.; Sotin, C.; Tobie, G.; Tokano, T.; Turtle, E.P.; Wahlund, J.-E.; Waite, J.H.; Baines, K.H.; Blamont, J.; Coates, A.J.; Dandouras, I.; Krimigis, T.; Lellouch, E.; Lorenz, R.D.; Morse, A.; Porco, C.C.; Hirtzig, M.; Saur, J.; Spilker, T.; Zarnecki, J.C.; Choi, E.; Achilleos, N.; Amils, R.; Annan, P.; Atkinson, D.H.; Benilan, Y.; Bertucci, C.; Bezard, B.; Bjoraker, G.L.; Blanc, M.; Boireau, L.; Bouman, J.; Cabane, M.; Capria, M.T.; Chassefiere, E.; Coll, P.; Combes, M.; Cooper, J.F.; Coradini, A.; Crary, F.; Cravens, T.; Daglis, I.A.; de Angelis, E.; De Bergh, C.; de Pater, I.; Dunford, C.; Durry, G.; Dutuit, O.; Fairbrother, D.; Flasar, F.M.; Fortes, A.D.; Frampton, R.; Fujimoto, M.; Galand, M.; Grasset, O.; Grott, M.; Haltigin, T.; Herique, A.; Hersant, F.; Hussmann, H.; Ip, W.; Johnson, R.; Kallio, E.; Kempf, S.; Knapmeyer, M.; Kofman, W.; Koop, R.; Kostiuk, T.; Krupp, N.; Kuppers, M.; Lammer, H.; Lara, L.-M.; Lavvas, P.; Le, Mouelic S.; Lebonnois, S.; Ledvina, S.; Li, J.; Livengood, T.A.; Lopes, R.M.; Lopez-Moreno, J. -J.; Luz, D.; Mahaffy, P.R.; Mall, U.; Martinez-Frias, J.; Marty, B.; McCord, T.; Salvan, C.M.; Milillo, A.; Mitchell, D.G.; Modolo, R.; Mousis, O.; Nakamura, M.; Neish, C.D.; Nixon, C.A.; Mvondo, D.N.; Orton, G.; Paetzold, M.; Pitman, J.; Pogrebenko, S.; Pollard, W.; Prieto-Ballesteros, O.; Rannou, P.; Reh, K.; Richter, L.; Robb, F.T.; Rodrigo, R.; Rodriguez, S.; Romani, P.; Bermejo, M.R.; Sarris, E.T.; Schenk, P.; Schmitt, B.; Schmitz, N.; Schulze-Makuch, D.; Schwingenschuh, K.; Selig, A.; Sicardy, B.; Soderblom, L.; Spilker, L.J.; Stam, D.; Steele, A.; Stephan, K.; Strobel, D.F.; Szego, K.; Szopa,

    2009-01-01

    TandEM was proposed as an L-class (large) mission in response to ESA's Cosmic Vision 2015-2025 Call, and accepted for further studies, with the goal of exploring Titan and Enceladus. The mission concept is to perform in situ investigations of two worlds tied together by location and properties, whose remarkable natures have been partly revealed by the ongoing Cassini-Huygens mission. These bodies still hold mysteries requiring a complete exploration using a variety of vehicles and instruments. TandEM is an ambitious mission because its targets are two of the most exciting and challenging bodies in the Solar System. It is designed to build on but exceed the scientific and technological accomplishments of the Cassini-Huygens mission, exploring Titan and Enceladus in ways that are not currently possible (full close-up and in situ coverage over long periods of time). In the current mission architecture, TandEM proposes to deliver two medium-sized spacecraft to the Saturnian system. One spacecraft would be an orbiter with a large host of instruments which would perform several Enceladus flybys and deliver penetrators to its surface before going into a dedicated orbit around Titan alone, while the other spacecraft would carry the Titan in situ investigation components, i.e. a hot-air balloon (Montgolfi??re) and possibly several landing probes to be delivered through the atmosphere. ?? Springer Science + Business Media B.V. 2008.

  6. Flow field interactions between two tandem cyclists

    Science.gov (United States)

    Barry, Nathan; Burton, David; Sheridan, John; Thompson, Mark; Brown, Nicholas A. T.

    2016-12-01

    Aerodynamic drag is the primary resistive force acting on cyclists at racing speeds. Many events involve cyclists travelling in very close proximity. Previous studies have shown that interactions result in significant drag reductions for inline cyclists. However, the interaction between cyclist leg position (pedalling) and the vortical flow structures that contribute significantly to the drag on an isolated cyclist has not previously been quantified or described for tandem cyclists of varying separation. To this end, scale model cyclists were constructed for testing in a water channel for inline tandem configurations. Particle image velocimetry was used to capture time-averaged velocity fields around two tandem cyclists. Perhaps surprisingly, the wake of a trailing cyclist maintains strong similarity to the characteristic wake of a single cyclist despite a significant disturbance to the upstream flow. Together with streamwise velocity measurements through the wake and upstream of the trailing cyclist, this work supports previous findings, which showed that the trailing cyclist drag reduction is primarily due to upstream sheltering effects reducing the stagnation pressure on forward-facing surfaces.

  7. Métodos exatos baseados em relaxações lagrangiana e surrogate para o problema de carregamento de paletes do produtor

    Directory of Open Access Journals (Sweden)

    Lilian Kátia de Oliveira

    2006-08-01

    Full Text Available Neste artigo apresentamos métodos exatos, baseados em relaxações Lagrangiana e surrogate, com bom desempenho para resolver o problema de carregamento de paletes do produtor. Este problema consiste em arranjar ortogonalmente e sem sobreposição o máximo número de retângulos de dimensões (l,w ou (l,w sobre um retângulo maior (L,W. Os métodos propostos são procedimentos de busca em árvore do tipo branch and bound que, em cada nó, utilizam limitantes derivados de relaxações Lagrangiana e/ou surrogate de uma formulação de programação linear 0-1. Algoritmos de otimização do subgradiente são usados para otimizar estes limitantes. São aplicados ainda testes de redução do problema e heurísticas Lagrangiana e surrogate para se obter boas soluções factíveis na otimização do subgradiente. Testes computacionais foram realizados utilizando exemplos da literatura e exemplos reais de uma transportadora. Os resultados mostram que um dos métodos propostos é competitivo com outros métodos da literatura, incluindo o software GAMS/CPLEX.In this paper we present exact methods, based on Lagrangean and surrogate relaxations, with good performance to solve the manufacturer's pallet loading problem. This problem consists of orthogonally arranging the maximum number of rectangles of sizes (l,w or (l,w into a larger rectangle (L,W without overlapping. The proposed methods involve a branch and bound based tree search procedure for which the bounds, in each node of the tree, are derived from Lagrangean and/or surrogate relaxations of a 0-1 linear programming formulation. Subgradient optimization algorithms are used to optimize such bounds. Problem reduction tests and Lagrangean and surrogate heuristics are also applied to obtain good feasible solutions in the subgradient optimization. Computational experiments were performed with instances of the literature and actual instances of a carrier. The results show that one of the proposed methods

  8. Um programa baseado na triagem visual de recém-nascidos em maternidades: Fundação Altino Ventura/2000

    Directory of Open Access Journals (Sweden)

    Ventura Liana Maria de O.

    2002-01-01

    Full Text Available Objetivo: Apresentar os dados obtidos de programa baseado na triagem visual de recém-nascidos, realizado em três maternidades públicas de referência do estado de Pernambuco, Brasil. Métodos: O projeto foi desenvolvido de forma prospectiva seguindo protocolo e organograma previamente elaborados. Para a sua execução contou-se com equipe multidisciplinar composta de 37 profissionais. Realizou-se a capacitação da equipe envolvida no projeto e ministrou-se palestras em cada maternidade, para os oftalmologistas, diretores, pediatras, neonatologistas, obstetras e enfermeiras. Os exames oftalmológicos foram realizados nas próprias maternidades públicas, com encaminhamento e tratamento dos casos de maior complexidade na sede da Fundação Altino Ventura. Pesquisou-se a flora conjuntival do recém-nascido e a vaginal materna, em 25 casos. Resultados: Capacitaram-se 20 oftalmologistas para o exame dos recém-nascidos. Examinaram-se 3.280 recém-nascidos (1.601 femininos e 1.679 masculinos. Foi detectado alguma anormalidade ocular ou fatores de risco em 701 casos (21,4%. A anormalidade ocular mais freqüente foi a hemorragia retiniana, vista em 255 casos (7,8%. O fator de risco para doença ocular de maior prevalência foi a retinopatia da prematuridade, detectada em 325 casos (9,9%, que foram encaminhados ao serviço especializado. Dos casos encaminhados, compareceram 65 pacientes (20,0%, e destes, em 15 casos (23,1% havia algum grau de retinopatia da prematuridade. Na pesquisa, quanto à flora conjuntival do recém-nascido (50 olhos, 13 olhos (26,0% apresentaram pelo menos um microrganismo. Em 18 casos de mães com cultura vaginal positiva para Staphylococcus epidermides, 10 (40,0% apresentaram filho com a mesma bactéria em um ou ambos os olhos. Conclusões: Os autores enfatizam o pioneirismo do projeto, ressalvando que possibilitou maior interação entre oftalmologistas e profissionais de áreas afins, treinamento de oftalmologistas para o

  9. Jogo da Minoria: um modelo baseado em agentes aplicado ao mercado financeiro Minority Game: an agent-based model applied to financial market

    Directory of Open Access Journals (Sweden)

    Antonio Fernando Crepaldi

    2012-12-01

    Full Text Available Nos últimos anos houve uma contribuição significativa dos físicos para a construção de um tipo de modelo baseado em agentes que busca reproduzir, em simulação computacional, o comportamento do mercado financeiro. Esse modelo, chamado Jogo da Minoria consiste de um grupo de agentes que vão ao mercado comprar ou vender ativos. Eles tomam decisões com base em estratégias e, por meio delas, os agentes estabelecem um intrincado jogo de competição e coordenação pela distribuição da riqueza. O modelo tem demonstrado resultados bastante ricos e surpreendentes, tanto na dinâmica do sistema como na capacidade de reproduzir características estatísticas e comportamentais do mercado financeiro. Neste artigo, são apresentadas a estrutura e a dinâmica do Jogo da Minoria, bem como as contribuições recentes relacionadas ao Jogo da Minoria denominado de Grande Canônico, que é um modelo mais bem ajustado às características do mercado financeiro e reproduz as regularidades estatísticas do preço dos ativos chamadas fatos estilizados.Over the past ten years physicists have made a significant contribution to the building of an agent-based model to reproduce the behavior of financial markets using computer simulation. This model, called the Minority Game, consists of a group of agents that buy or sell assets. They make decisions based on strategies, and through them the agents establish an intricate game of competition and coordination resulting in the distribution of wealth. The model has shown outstanding surprising results concerning both the dynamics of the system and the ability to reproduce statistical and behavior characteristics of the financial market. In this study, the structure and dynamics of the Minority Game and the recent contributions related to the Grand Canonical Minority game, a model which is better adapted to the characteristics of the financial market and reproduce the statistical regularities of asset prices (called

  10. PROPOSTA DE CONTROLE BASEADO EM CRITÉRIO DE ESTABILIDADE ROBUSTA: UMA ABORDAGEM EM TERMOS DE FUNÇÃO DE TRANSFERÊNCIA APLICADA A SISTEMAS DINÂMICOS NO TEMPO CONTÍNUO COM ATRASO

    OpenAIRE

    2012-01-01

    Nesta dissertação é proposta uma metodologia de controle PID nebuloso robusto baseado nas especificações das margens de ganho e fase, para sistemas dinâmicos com atraso, no domínio do tempo contínuo. Um modelo nebuloso com estrutura Takagi-Sugeno é utilizado para representar o sistema dinâmico a ser controlado. Assim, a partir dos dados de entrada e saída do sistema dinâmico, o algoritmo de agrupamento nebuloso Gustafson-Kessel é utilizado para estimar os parâmetros da proposição ...

  11. Efeito da inclusão de exercícios técnicos de baixa intensidade entre os pares de exercícios baseado no complex training em pré-púberes

    OpenAIRE

    Martins, Bruno Norberto Vieira

    2016-01-01

    Dissertação de Mestrado em Ciências do Desporto, Especialização em Avaliação e Prescrição na Actividade Física A variável do tempo de descanso entre pares de exercícios, baseados no Complex Training (CT), interfere, significativamente, na operacionalização desta metodologia em contexto Desportivo, nomeadamente nos Jogos Desportivos. O presente estudo, teve como objetivo, analisar o efeito de 4 formas de intervalo entre os pares de exercícios, Agachamento (AG) e os gestos técnicos (GT), que...

  12. CÁLCULO DO CUSTO DAS ATIVIDADES DE GESTÃO AMBIENTAL: APLICAÇÃO DO CUSTEIO BASEADO EM ATIVIDADES NUMA MONTADORA DE ÔNIBUS ENVIRONMENTAL MANAGEMENT COST CALCULATION: ACTIVITY BASED COSTING APPLIED TO BUS ASSEMBLY PROCESS

    Directory of Open Access Journals (Sweden)

    Orlando Durán

    2007-08-01

    Full Text Available Este trabalho apresenta os resultados da aplicação da metodologia de custeio baseado em atividades para medir o impacto que as atividades de gestão ambiental podem ter no custo industrial dos produtos. Um estudo de caso é apresentado junto com a utilização de um software comercial para o cálculo dos custos.This manuscript presents an Activity Based Costing application in an environmental protection context. The aim of this work is measuring the impact of environmental management activities on product costs. Also, a case study is discussed and the utilization of commercial software is presented.

  13. VisionDraughts - um sistema de aprendizagem de jogos de damas baseado em redes neurais, diferenças temporais, algoritmos eficientes de busca em árvores e informações perfeitas contidas em bases de dados

    OpenAIRE

    Caexêta, Gutierrez Soares

    2008-01-01

    O objetivo deste trabalho é propor um sistema de aprendizagem de damas, Vision-Draughts, baseado nos trabalhos de Neto e Julia (LS-Draughts) e de Mark Lynch (NeuroDraughts). O NeuroDraughts é um bom jogador automático de damas que utiliza a técnica de aprendizagem por diferenças temporais para ajustar os pesos de uma rede neural artificial multi-camadas cujo papel é estimar o quanto um estado do tabuleiro do jogo, representado em sua camada de entrada através do mapeamento NET-FEA...

  14. Hidrogéis semi-IPN baseados em rede de alginato-Ca2+ com PNIPAAm entrelaçado: propriedades hidrofílicas, morfológicas e mecânicas

    OpenAIRE

    Márcia R. de Moura; Adley F. Rubira; Edvani C. Muniz

    2008-01-01

    Neste trabalho, a termossensibilidade dos hidrogéis do tipo semi-IPN baseados em rede de alginato-Ca2+com poli(N-isopropil acrilamida) (PNIPAAm) entrelaçado, com diferentes teores de alginato e de PNIPAAm, foi caracterizada por meio de medidas de grau de intumescimento (Q), microscopia eletrônica de varredura (MEV) e propriedades mecânicas [tensão máxima de compressão (σ), densidade aparente de reticulação (νe) e módulo de elasticidade (E)]. Os valores de Q variam inversamente com &...

  15. Avaliação dos efeitos do antioxidante n-acetil-l-cisteína em um modelo animal de esquizofrenia baseado no neurodesenvolvimento utilizando o acetato de metilazoximetanol

    OpenAIRE

    2016-01-01

    Orientadora: Profa. Dra. Cristiane Otero Reis Salum Dissertação (mestrado) - Universidade Federal do ABC, Programa de Pós-Graduação em Neurociência e Cognição, 2016. O fortalecimento da hipótese de neurodesenvolvimento deficiente na esquizofrenia tem levado à utilização de modelos animais baseados em intervenções nesta fase. Um destes é o modelo que consiste na injeção do antimitótico acetato de metilazoximetanol (MAM) no décimo sétimo dia de gestação de ratas Wistar. Os filhot...

  16. Flexible and fragmentable tandem photosensitive nanocrystal skins

    Science.gov (United States)

    Akhavan, S.; Uran, C.; Bozok, B.; Gungor, K.; Kelestemur, Y.; Lesnyak, V.; Gaponik, N.; Eychmüller, A.; Demir, H. V.

    2016-02-01

    We proposed and demonstrated the first account of large-area, semi-transparent, tandem photosensitive nanocrystal skins (PNSs) constructed on flexible substrates operating on the principle of photogenerated potential buildup, which avoid the need for applying an external bias and circumvent the current-matching limitation between junctions. We successfully fabricated and operated the tandem PNSs composed of single monolayers of colloidal water-soluble CdTe and CdHgTe nanocrystals (NCs) in adjacent junctions on a Kapton polymer tape. Owing to the usage of a single NC layer in each junction, noise generation was significantly reduced while keeping the resulting PNS films considerably transparent. In each junction, photogenerated excitons are dissociated at the interface of the semi-transparent Al electrode and the NC layer, with holes migrating to the contact electrode and electrons trapped in the NCs. As a result, the tandem PNSs lead to an open-circuit photovoltage buildup equal to the sum of those of the two single junctions, exhibiting a total voltage buildup of 128.4 mV at an excitation intensity of 75.8 μW cm-2 at 350 nm. Furthermore, we showed that these flexible PNSs could be bent over 3.5 mm radius of curvature and cut out in arbitrary shapes without damaging the operation of individual parts and without introducing any significant loss in the total sensitivity. These findings indicate that the NC skins are promising as building blocks to make low-cost, flexible, large-area UV/visible sensing platforms with highly efficient full-spectrum conversion.We proposed and demonstrated the first account of large-area, semi-transparent, tandem photosensitive nanocrystal skins (PNSs) constructed on flexible substrates operating on the principle of photogenerated potential buildup, which avoid the need for applying an external bias and circumvent the current-matching limitation between junctions. We successfully fabricated and operated the tandem PNSs composed of

  17. Tandem robot control system and method for controlling mobile robots in tandem

    Energy Technology Data Exchange (ETDEWEB)

    Hayward, David R. (Albuquerque, NM); Buttz, James H. (Albuquerque, NM); Shirey, David L. (Albuquerque, NM)

    2002-01-01

    A control system for controlling mobile robots provides a way to control mobile robots, connected in tandem with coupling devices, to navigate across difficult terrain or in closed spaces. The mobile robots can be controlled cooperatively as a coupled system in linked mode or controlled individually as separate robots.

  18. HRIBF Tandem Accelerator Radiation Safety System Upgrade

    Energy Technology Data Exchange (ETDEWEB)

    Blankenship, J.L.; Juras, R.C.

    1998-11-04

    The HRIBF Tandem Accelerator Radiation Safety System was designed to permit experimenters and operations staff controlled access to beam transport and experiment areas with accelerated beam present. Neutron-Gamma detectors are mounted in eaeh area at points of maximum dose rate and the resulting signals are integrated by redundan~ circuitry; beam is stopped if dose rate or integrated dose exceeds established limits. This paper will describe the system, in use for several vears at the HRIBF, and discuss changes recently made to modernize the system and to make the system compliant with DOE Order 5480.25 and related ORNL updated safety rules.

  19. A Hybrid Approach To Tandem Cylinder Noise

    Science.gov (United States)

    Lockard, David P.

    2004-01-01

    Aeolian tone generation from tandem cylinders is predicted using a hybrid approach. A standard computational fluid dynamics (CFD) code is used to compute the unsteady flow around the cylinders, and the acoustics are calculated using the acoustic analogy. The CFD code is nominally second order in space and time and includes several turbulence models, but the SST k - omega model is used for most of the calculations. Significant variation is observed between laminar and turbulent cases, and with changes in the turbulence model. A two-dimensional implementation of the Ffowcs Williams-Hawkings (FW-H) equation is used to predict the far-field noise.

  20. Method of fabricating bifacial tandem solar cells

    Energy Technology Data Exchange (ETDEWEB)

    Wojtczuk, Steven J; Chiu, Philip T; Zhang, Xuebing; Gagnon, Edward; Timmons, Michael

    2014-10-07

    A method of fabricating on a semiconductor substrate bifacial tandem solar cells with semiconductor subcells having a lower bandgap than the substrate bandgap on one side of the substrate and with subcells having a higher bandgap than the substrate on the other including, first, growing a lower bandgap subcell on one substrate side that uses only the same periodic table group V material in the dislocation-reducing grading layers and bottom subcells as is present in the substrate and after the initial growth is complete and then flipping the substrate and growing the higher bandgap subcells on the opposite substrate side which can be of different group V material.

  1. Turkish population data on the short tandem repeat locus TPOX

    DEFF Research Database (Denmark)

    Vural, B; Poda, M; Atlioglu, E;

    1998-01-01

    Allele and genotype frequencies were determined for the STR (short tandem repeat) locus TPOX in a random Turkish population sample of 200 individuals.......Allele and genotype frequencies were determined for the STR (short tandem repeat) locus TPOX in a random Turkish population sample of 200 individuals....

  2. Negotiating Multiple Identities through eTandem Learning Experiences

    Science.gov (United States)

    Yang, Se Jeong; Yi, Youngjoo

    2017-01-01

    Much of eTandem research has investigated either linguistic or cross-cultural aspects of second language (L2) learning, but relatively little is known about issues of identity construction in an eTandem context. Situating the study within theories and research of language learner identity, we examined ways in which two adult L2 learners (a Korean…

  3. Interpretation of tandem mass spectra of posttranslationally modified peptides

    DEFF Research Database (Denmark)

    Bunkenborg, J.; Matthiesen, R.

    2013-01-01

    Tandem mass spectrometry provides a sensitive means of analyzing the amino acid sequence of peptides and modified peptides by providing accurate mass measurements of precursor and fragment ions. Modern mass spectrometry instrumentation is capable of rapidly generating many thousands of tandem mas...

  4. Proposta de Sistema de Informação para Atenção Farmacêutica baseado no Método Dáder

    Directory of Open Access Journals (Sweden)

    CLáUDIA SEIKO YOKOYAMA

    2011-06-01

    Full Text Available A característica principal do Acompanhamento Farmacoterapêutico, um dos macrocomponentes da Atenção Farmacêutica, é a documentação sistemática de informações para solução dos Problemas Relacionados aos Medicamentos (PRM. Essa documentação é feita, com frequência, de forma não automatizada e com o preenchimento de fichas manuais catalogadas em arquivos, o que dificulta a sua organização e torna o processo de recuperação dos dados exaustivo e complicado, limitando a sua aplicação no cotidiano. Uma maneira de minimizar estes problemas é utilizar um sistema de informação para dinamizar esse processo, facilitar o acesso aos dados da terapia e melhorar a comunicação entre o médico e a equipe de saúde responsável pelo paciente. Este artigo apresenta, portanto, o desenvolvimento de um sistema para Atenção Farmacêutica baseado no método Dáder, denominado Farmatools. Esse sistema tem como objetivo informatizar o método Dáder, facilitando o acompanhamento farmacoterapêutico, otimizando o tempo de visita e melhorando a recuperação de informação e a comunicação entre os profissionais de saúde. O Farmatools visa melhorar o acesso à informação, diminuindo a inacessibilidade e a perda das informações. Palavras-chave: Atenção Famacêutica. Farmacoterapia. Sistema de Informação. ABSTRACT Proposal of an Information System for Pharmaceutical Care based on Dader Method These registrations are often not automated, but done by filling manual forms, that are cataloged. Over time, with the increase in attendances, there is an increase in the number of forms (amount of paper, making the recovery data process extensive and complicated, thereby, its application in daily life. One way to minimize these problems is to use an information system to improve the process and facilitate the data access recorded during the visits, improving communication with the doctor and the health care team responsible for the patient

  5. A solution process for inverted tandem solar cells

    DEFF Research Database (Denmark)

    Larsen-Olsen, Thue Trofod; Bundgaard, Eva; Sylvester-Hvid, Kristian O.

    2011-01-01

    Tandem solar cells with normal and inverted device geometries were prepared by a solution process. Both device types were based on the use of zinc(II)oxide as the electron transporting layer (ETL). The hole transporting layer (HTL) was either PEDOT:PSS for normal geometry tandem solar cells...... or vanadium(V)oxide in the case of inverted tandem cells. It was found that the inverted tandem solar cells performed comparable or better than the normal geometry devices, showing that the connection structure of vanadium(V)oxide, Ag nanoparticles and zinc(II)oxide functions both as a good recombination...... layer, ensuring serial connection, and as a solvent barrier, protecting the first photoactive layer from processing of the second layer. This successfully demonstrates a tandem solar cell fabrication process fully compatible with state-of-the-art solution based automated production procedures....

  6. Tandem come tirocinio: la riflessione nel corso dell'azione - in un tandem in presenza italiano-portoghese

    Directory of Open Access Journals (Sweden)

    Maria Luisa Vassallo

    2006-04-01

    Full Text Available II presente studio è dedicato al Tandem, un metodo di studio delle lingue straniere autonomo e collaborativo. Esso illustra alcune potenzialità di questa forma didattica per la formazione degli insegnanti, utilizzando il concetto di riflessione nel corso dell'azione elaborato dal filosofo statunitense Donald Schön (1983. Il capitolo 1 introduce il metodo Tandem. Il capitolo 2 analizza il Tandem alla luce della teoria di Schön. Il capitolo 3 descrive l'aspetto riflessivo in un Tandem in presenza, svolto nel 2004 in Brasile. II capitolo 4 propone alcuni motivi per considerare il metodo Tandem un contesto complementare utile per la formazione alla pratica docente attraverso il tirocinio.

  7. Folded tandem ion accelerator facility at Trombay

    Indian Academy of Sciences (India)

    P Singh

    2001-08-01

    The folded tandem ion accelerator (FOTIA) project at BARC has been commissioned. The analysed carbon beams of 40 nA(3+) and 25 nA(4+), at terminal voltage of 2.5 MV with N2 + CO2 as insulating gas, were obtained. The beams were characterized by performing the Rutherford back scattering (RBS) on gold, tin and iron targets. The beam energy of 12.5 MeV for 12C4+ was consistent with the terminal voltage of 2.5 MV. The N2 + CO2 mixture is being replaced by SF6 gas in order to achieve 6 MV on the terminal. In this paper, some of the salient features of the FOTIA and its present status are discussed.

  8. Sugarcane Tandem Mills Operation at Two Hydraulic Pressure Levels

    Directory of Open Access Journals (Sweden)

    Jorge Michel Corrales-Suárez

    2015-01-01

    Full Text Available Among the areas with more energy consumption in a sugar factory is the tandem of mills. The applied hydraulic pressure on the superior mace is one of the variables that have influence on this energy consumption. Hydraulic pressures were decreased in a value that did not affect the extraction process efficiency to determine the possibilities of decreasing this energy consumption. The research was carried out in two sugar cane tandems of six mills. The pressures were only varied in the extraction mills in humid according to a statistical design of experiments in random blocks. The results were analyzed by means of the analysis of variance of double classification. The independent variables were the hydraulic pressures in the intermediate mills while the dependent variables were the % pol and % humidity of the final bagasse. The hydraulic pressures of the intermediate mills were reduced 3.45 MPa in the Tandem 1 and 2.07 MPa in the Tandem 2. It was demonstrated that under the conditions of the experiment, the employment of working hydraulic pressures smaller than the usually established ones for each tandem did not affect the extraction process of the sugar cane sucrose significantly, but decreased 11.75% the power demand on tandem 1 and 8.17% on tandem 2.

  9. Numerical evaluation of tandem rotor for highly loaded transonic fan

    Institute of Scientific and Technical Information of China (English)

    ZHAO Bin; LIU Bao-jie

    2011-01-01

    Transonic tandem rotor was designed for highly loaded fan at a corrected tip speed of 381 m/s and another conventional rotor was designed as a baseline to evaluate the loading superiority of tandem rotor with three-dimensional (3-D) numerical simulation. The aft blade solidity and its impact on total loading level were studied in depth. The result indicates that tandem rotor has potential to achieve higher loading level and attain favorable aerodynamic performance in a wide range of loading coefficient 0. 55 ~ 0.68, comparing with the conventional rotor which produced a total pressure ratio of 2.0 and loading coefficient of 0. 42.

  10. Desenvolvendo um processo de análise de investimentos baseado em competências Developping an investimento analysis process based on competences

    Directory of Open Access Journals (Sweden)

    Ronald Nieweglowski

    2010-01-01

    Full Text Available O conjunto de competências organizacionais que uma empresa emprega na realização de suas operações, potencialmente define sua capacidade de realizar uma determinada estratégia de negócios. O presente artigo se propõe a desenvolver um processo para a análise de projetos de investimento baseado em competências. O estudo se desenrola no âmbito das pequenas empresas e se aplica a projetos de expansão da capacidade. A abordagem desenvolvida fundamenta-se na construção de um framework teórico-conceitual, sendo este refinado por um conjunto de entrevistas realizadas com especialistas. Participam das entrevistas três analistas pleno de investimento e três acadêmicos das áreas de gestão estratégica de operações e gestão econômica da produção. O processo desenvolvido é testado em casos de simulação que se utilizam de dados obtidos de três projetos de investimento analisados por um banco de desenvolvimento, no período de março de 2002 a setembro de 2003. Os casos se distribuem entre os setores de manufatura, comércio de serviços. O resultado do trabalho é um processo de análise de investimentos que usa o conceito de competências empresariais para avaliar a capacidade de uma empresa em gerar resultados. O processo desenvolvido vincula recursos e competências à estratégia empresarial adotada, avaliando as condições necessárias para o desenvolvimento da estratégia. O estudo é de natureza exploratória e, portanto, não permite generalizações. Há necessidade de se ampliar o número de simulações e testar o uso do processo com diferentes analistas de investimento. A principal implicação prática do trabalho reside no fato de se propor um procedimento estruturado para a análise de projetos de investimento para pequenas empresas, dadas as dificuldades de se obter informações econômico-financeiras destas empresas. A pesquisa realizada contribui para o desenvolvimento de metodologias para análise de projetos

  11. Sistema para localização robótica de veículos autônomos baseado em visão computacional por pontos de referência

    OpenAIRE

    Leandro Nogueira Couto

    2012-01-01

    A integração de sistemas de Visão Computacional com a Robótica Móvel é um campo de grande interesse na pesquisa. Este trabalho demonstra um método de localização global para Robôs Móveis Autônomos baseado na criação de uma memória visual, através da detecção e descrição de pontos de referência de imagens capturadas, com o método SURF, associados a dados de odometria, em um ambiente interno. O procedimento proposto, associado com conhecimento específico sobre o ambiente, permite que a localiza...

  12. Monolithic Perovskite Silicon Tandem Solar Cells with Advanced Optics

    Energy Technology Data Exchange (ETDEWEB)

    Goldschmidt, Jan C.; Bett, Alexander J.; Bivour, Martin; Blasi, Benedikt; Eisenlohr, Johannes; Kohlstadt, Markus; Lee, Seunghun; Mastroianni, Simone; Mundt, Laura; Mundus, Markus; Ndione, Paul; Reichel, Christian; Schubert, Martin; Schulze, Patricia S.; Tucher, Nico; Veit, Clemens; Veurman, Welmoed; Wienands, Karl; Winkler, Kristina; Wurfel, Uli; Glunz, Stefan W.; Hermle, Martin

    2016-11-14

    For high efficiency monolithic perovskite silicon tandem solar cells, we develop low-temperature processes for the perovskite top cell, rear-side light trapping, optimized perovskite growth, transparent contacts and adapted characterization methods.

  13. Light management of tandem solar cells on nanostructured substrates

    Science.gov (United States)

    Chin, Alan H.; Keshavarz, Majid; Wang, Guo; Yu, Rosaline; Niu, Xinwei; Yang, Liyou

    2017-04-01

    We report the use of nanostructured substrates as a simple approach to improve the performance of tandem micromorph silicon solar cells. In the proposed approach, nanostructured substrates are produced using a low-cost, self-assembled growth process. The use of a nanostructured substrate coated with a thick transparent conductive oxide electrode layer enables the conformal deposition of the tandem solar cell absorber layers while allowing the solar cell to exhibit a modified surface morphology caused by the underlying nanostructured morphology. Using this nanostructured substrate approach, we demonstrated a 78% relative enhancement in the conversion efficiency of a tandem micromorph silicon cell on a nanostructured substrate compared to a standard tandem micromorph cell deposited onto a flat substrate.

  14. Detailed balance limit of the efficiency of tandem solar cells

    Science.gov (United States)

    de Vos, A.

    1980-05-01

    The fundamental (detailed balance) limit of the performance of a tandem structure is presented. The model takes into account the fact that a particular cell is not only illuminated by part of the solar irradiance but also by the electroluminescence of other cells of the set. Whereas under 1 sun irradiance a single solar cell only converts 30% of the solar energy, a tandem structure of two cells can convert 42%, a tandem structure of three cells can convert 49%, etc. Under the highest possible light concentration, these efficiencies are 40% (one cell), 55% (two cells), 63% (three cells), etc. The model also allows one to predict the ideal efficiency of a stack with an infinite number of solar cells. Such a tandem system can convert 68% of the unconcentrated sunlight, and 86% of the concentrated sunlight.

  15. Solar-to-Chemical Energy Conversion with Photoelectrochemical Tandem Cells.

    Science.gov (United States)

    Sivula, Kevin

    2013-01-01

    Efficiently and inexpensively converting solar energy into chemical fuels is an important goal towards a sustainable energy economy. An integrated tandem cell approach could reasonably convert over 20% of the sun's energy directly into chemical fuels like H2 via water splitting. Many different systems have been investigated using various combinations of photovoltaic cells and photoelectrodes, but in order to be economically competitive with the production of H2 from fossil fuels, a practical water splitting tandem cell must optimize cost, longevity and performance. In this short review, the practical aspects of solar fuel production are considered from the perspective of a semiconductor-based tandem cell and the latest advances with a very promising technology - metal oxide photoelectrochemical tandem cells - are presented.

  16. Zinc Mediated Tandem Fragmentation-Allylation of Methyl 5-Iodopentofuranosides

    DEFF Research Database (Denmark)

    Hyldtoft, Lene; Madsen, Robert

    1999-01-01

    In the presence of zinc and allyl bromide methyl 5-iodopentofuranosides undergo a tandem fragmentation alkylation to give functionalized dienes. These can undergo ring-closing olefin metathesis to produce cyclohexenes which on dihydroxylation give quercitols....

  17. SYMTRAN - A Time-dependent Symmetric Tandem Mirror Transport Code

    Energy Technology Data Exchange (ETDEWEB)

    Hua, D; Fowler, T

    2004-06-15

    A time-dependent version of the steady-state radial transport model in symmetric tandem mirrors in Ref. [1] has been coded up and first tests performed. Our code, named SYMTRAN, is an adaptation of the earlier SPHERE code for spheromaks, now modified for tandem mirror physics. Motivated by Post's new concept of kinetic stabilization of symmetric mirrors, it is an extension of the earlier TAMRAC rate-equation code omitting radial transport [2], which successfully accounted for experimental results in TMX. The SYMTRAN code differs from the earlier tandem mirror radial transport code TMT in that our code is focused on axisymmetric tandem mirrors and classical diffusion, whereas TMT emphasized non-ambipolar transport in TMX and MFTF-B due to yin-yang plugs and non-symmetric transitions between the plugs and axisymmetric center cell. Both codes exhibit interesting but different non-linear behavior.

  18. Solution-Processed Nanocrystal Quantum Dot Tandem Solar Cells

    KAUST Repository

    Choi, Joshua J.

    2011-06-03

    Solution-processed tandem solar cells created from nanocrystal quantum dots with size-tuned energy levels are demonstrated. Prototype devices featuring interconnected quantum dot layers of cascaded energy gaps exhibit IR sensitivity and an open circuit voltage, V oc, approaching 1 V. The tandem solar cell performance depends critically on the optical and electrical properties of the interlayer. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  19. Zinc Mediated Tandem Fragmentation-Allylation of Methyl 5-Iodopentofuranosides

    DEFF Research Database (Denmark)

    Hyldtoft, Lene; Madsen, Robert

    1999-01-01

    In the presence of zinc and allyl bromide methyl 5-iodopentofuranosides undergo a tandem fragmentation alkylation to give functionalized dienes. These can undergo ring-closing olefin metathesis to produce cyclohexenes which on dihydroxylation give quercitols.......In the presence of zinc and allyl bromide methyl 5-iodopentofuranosides undergo a tandem fragmentation alkylation to give functionalized dienes. These can undergo ring-closing olefin metathesis to produce cyclohexenes which on dihydroxylation give quercitols....

  20. Solution-processed nanocrystal quantum dot tandem solar cells

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Joshua J.; Lim, Yee-Fun [School of Applied and Engineering Physics, Cornell University, Ithaca, NY 14853 (United States); Wenger, Whitney N.; Hoffman, Rachel S.; Hanrath, Tobias [School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY 14853 (United States); Luria, Justin; Marohn, John A. [Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853 (United States); Jasieniak, Jacek [CSIRO Materials Science and Engineering, Bayview Ave, Clayton, Victoria 3168 (Australia)

    2011-07-26

    Solution-processed tandem solar cells created from nanocrystal quantum dots with size-tuned energy levels are demonstrated. Prototype devices featuring interconnected quantum dot layers of cascaded energy gaps exhibit IR sensitivity and an open circuit voltage, V{sub oc}, approaching 1 V. The tandem solar cell performance depends critically on the optical and electrical properties of the interlayer. (Copyright copyright 2011 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  1. Intragenic tandem repeat variation between Legionella pneumophila strains

    Directory of Open Access Journals (Sweden)

    Jarraud Sophie

    2008-12-01

    Full Text Available Abstract Background Bacterial genomes harbour a large number of tandem repeats, yet the possible phenotypic effects of those found within the coding region of genes are only beginning to be examined. Evidence exists from other organisms that these repeats can be involved in the evolution of new genes, gene regulation, adaptation, resistance to environmental stresses, and avoidance of the immune system. Results In this study, we have investigated the presence and variability in copy number of intragenic tandemly repeated sequences in the genome of Legionella pneumophila, the etiological agent of a severe pneumonia known as Legionnaires' disease. Within the genome of the Philadelphia strain, we have identified 26 intragenic tandem repeat sequences using conservative selection criteria. Of these, seven were "polymorphic" in terms of repeat copy number between a large number of L. pneumophila serogroup 1 strains. These strains were collected from a wide variety of environments and patients in several geographical regions. Within this panel of strains, all but one of these seven genes exhibited statistically different patterns in repeat copy number between samples from different origins (environmental, clinical, and hot springs. Conclusion These results support the hypothesis that intragenic tandem repeats could play a role in virulence and adaptation to different environments. While tandem repeats are an increasingly popular focus of molecular typing studies in prokaryotes, including in L. pneumophila, this study is the first examining the difference in tandem repeat distribution as a function of clinical or environmental origin.

  2. Traditional and modern medicine working in tandem

    Directory of Open Access Journals (Sweden)

    E. Pretorius

    1991-09-01

    Full Text Available Because of the many problem relating to health care delivery in Africa, it is becoming apparent that neither the exclusive/monopolistic nor the tolerant legislative systems should be tolerated any longer. Especially since the Alma Ata Conference held by the WHO/UNICEF there has been growing impetus towards either inclusive/parallel (the beneficial co-existence of traditional and modern medical systems, or integrated systems. Although the idea of making traditional and modern medicine work in tandem in a united treatment context has its merits, it is also plagued by issues such as the nature of the products of an integrated training, resistance by stubborn protagonists of either of the two systems, or that only lip-service is paid to the idea of co-operation. Nevertheless, it is believed that all interest groups - the authorities responsible for health care delivery, the Western-trained health care workers, the traditional healers and the users of these services - stand to gain from such liaison.

  3. Wake-induced vibrations in Tandem Cylinders

    Science.gov (United States)

    Mysa, Ravi Chaithanya; Jaiman, Rajeev Kumar

    2015-11-01

    The upstream cylinder is fixed in the tandem cylinders arrangement. The downstream cylinder is placed at a distance of four diameters from the upstream cylinder in the free stream direction and is mounted on a spring. The dynamic response of the downstream cylinder is studied at Reynolds number of 10,000. The transverse displacement amplitude of the downstream cylinder is larger compared to that of single cylinder in the post-lock-in region. The transverse dynamic response of the downstream cylinder in the post-lock-in region is characterized by a dominant low frequency component compared to shed frequency, which is nearer to the structural natural frequency. The interaction of upstream wake with the downstream cylinder is carefully analyzed to understand the introduction of low frequency component in the transverse load along with the shed frequency. We found that the stagnation point moves in proportional to the velocity of the cylinder and is in-phase with the velocity. The low frequency component in the stagnation point movement on the downstream cylinder is sustained by the interaction of upstream wake. The frequencies in the movement of the stagnation point is reflected in the transverse load resulting in large deformation of the cylinder. The authors wish to acknowledge support from A*STAR- SERC and Singapore Maritime Institute.

  4. Tandem mass spectrometry: analysis of complex mixtures

    Energy Technology Data Exchange (ETDEWEB)

    Singleton, K.E.

    1985-01-01

    Applications of tandem mass spectrometry (MS/MS) for the analysis of complex mixtures results in increased specificity and selectivity by using a variety of reagent gases in both negative and positive ion modes. Natural isotopic abundance ratios were examined in both simple and complex mixtures using parent, daughter and neutral loss scans. MS/MS was also used to discover new compounds. Daughter scans were used to identify seven new alkaloids in a cactus species. Three of these alkaloids were novel compounds, and included the first simple, fully aromatic isoquinoline alkaloids reported in Cactaceae. MS/MS was used to characterize the chemical reaction products of coal in studies designed to probe its macromolecular structure. Negative ion chemical ionization was utilized to study reaction products resulting from the oxidation of coal. Possible structural units in the precursor coal were predicted based on the reaction products identified, aliphatic and aromatic acids and their anhydrides. The MS/MS method was also used to characterize reaction products resulting from coal liquefaction and/or extraction. These studies illustrate the types of problems for which MS/MS is useful. Emphasis has been placed on characterization of complex mixtures by selecting experimental parameters which enhance the information obtained. The value of using MS/MS in conjunction with other analytical techniques as well as the chemical pretreatment is demonstrated.

  5. Actualization of the Tandem-E N Accelerator of the Nuclear Centre of Mexico; Actualizacion del Acelerador Tandem-EN del Centro Nuclear

    Energy Technology Data Exchange (ETDEWEB)

    Villasenor S, P.; Aguilera R, E.; Aspiazu F, J.; Fernandez A, J.; Fernandez B, M.; Garcia R, B.; Lopez M, J.; Martinez Q, E.; Mendez G, B.; Moreno B, E.; Murillo O, G.; Policroniades R, R.; Ramirez T, J.; Reynoso V, R.; Varela G, A.; Vega C, J. [ININ, 52045 Ocoyoacac, Estado de Mexico (Mexico)

    2004-07-01

    In this work, the activities are described carried out to change the tubes accelerators and original resistances of the accelerator Tandem-E N of the Nuclear Center, for tubes DOWLISH and resistances again design, both donated ones for ORNL. This way same, the problem is described that imply this changes, and like it was solved by the personnel of the laboratory, without having to appeal to external services, what there is redounded in a considerable increment in the costs. In form preliminary the improvements are described observed after the rehabilitation of the Accelerator. (Author)

  6. Novel multiplex format of an extended multilocus variable-number-tandem-repeat analysis of Clostridium difficile correlates with tandem repeat sequence typing.

    Science.gov (United States)

    Jensen, Mie Birgitte Frid; Engberg, Jørgen; Larsson, Jonas T; Olsen, Katharina E P; Torpdahl, Mia

    2015-03-01

    Subtyping of Clostridium difficile is crucial for outbreak investigations. An extended multilocus variable-number tandem-repeat analysis (eMLVA) of 14 variable number tandem repeat (VNTR) loci was validated in multiplex format compatible with a routine typing laboratory and showed excellent concordance with tandem repeat sequence typing (TRST) and high discriminatory power.

  7. The impact of genome triplication on tandem gene evolution in Brassica rapa

    Directory of Open Access Journals (Sweden)

    Lu eFang

    2012-11-01

    Full Text Available Whole genome duplication (WGD and tandem duplication (TD are both important modes of gene expansion. However, how whole genome duplication influences tandemly duplicated genes is not well studied. We used Brassica rapa, which has undergone an additional genome triplication (WGT and shares a common ancestor with Arabidopsis thaliana, Arabidopsis lyrata and Thellungiella parvula, to investigate the impact of genome triplication on tandem gene evolution. We identified 2,137, 1,569, 1,751 and 1,135 tandem gene arrays in B. rapa, A. thaliana, A. lyrata and T. parvula respectively. Among them, 414 conserved tandem arrays are shared by the 3 species without WGT, which were also considered as existing in the diploid ancestor of B. rapa. Thus, after genome triplication, B. rapa should have 1,242 tandem arrays according to the 414 conserved tandems. Here, we found 400 out of the 414 tandems had at least one syntenic ortholog in the genome of B. rapa. Furthermore, 294 out of the 400 shared syntenic orthologs maintain tandem arrays (more than one gene for each syntenic hit in B. rapa. For the 294 tandem arrays, we obtained 426 copies of syntenic paralogous tandems in the triplicated genome of B. rapa. In this study, we demonstrated that tandem arrays in B. rapa were dramatically fractionated after WGT when compared either to non-tandem genes in the B. rapa genome or to the tandem arrays in closely related species that have not experienced a recent whole-genome polyploidization event.

  8. Design of a new tandem wings hybrid airship

    Science.gov (United States)

    Li, Feng; Ye, ZhengYin; Gao, Chao

    2012-10-01

    It is scientifically important science value and engineering promising to develop the buoyancy-lift integrated hybrid airship for high attitude platform. Through the numerical method, a new tandem wings hybrid airship with both higher utility value and economy efficiency was obtained and its total performance and technical parameters were analyzed in detail. In order to further improve the lift-drag characteristics, we implemented the optimization design for aerodynamic configuration of tandem wings hybrid airship via the response surface method. The results indicate that the tandem wings hybrid airship has considerable volume efficiency and higher aerodynamic characteristics. After optimization, the lift-drag ratio of this hybrid airship was increased by 6.08%. In a given gross lift condition, tandem wings hybrid airship may provide more payload and specific productivity. Furthermore, the size of tandem airship is smaller so the demand for skin flexible materials can be reduced. Results of this study could serve as a new approach to designing buoyancy-lifting integrated hybrid airship.

  9. Test of the Tandem transmission at low terminal voltages

    Energy Technology Data Exchange (ETDEWEB)

    Rehm, K.E.; Blumenthal, D.; Gehring, J. [and others

    1995-08-01

    For a planned experiment with {sup 18}F beams at energies below 1 MeV/u the transmission of the Tandem-Linac system was investigated. The energies required in the experiment are typically around 600 keV/u, which for the most abundant charge states for F(4{sup +}) corresponds to terminal voltages between 2-3 MV. We studied the transmission from the source to the tandem accelerator and to the spectrograph in area II with {sup 18}O and {sup 19}F beams using two different approaches. In the first method only the tandem accelerator was used producing a 14-MeV DC {sup 18}O beam. In the second method a pulsed beam was accelerated to 33 MeV with the tandem accelerator followed by deceleration to 14 MeV with the first 9 resonators of ATLAS. The total transmission from ion source to target was in both cases about 10%. Because of the smaller complexity we used the first method for the {sup 18}F experiment. In future runs we are planning to use the electrostatic lens in the terminal of the tandem to improve the overall transmission.

  10. High-Efficiency Polycrystalline Thin Film Tandem Solar Cells.

    Science.gov (United States)

    Kranz, Lukas; Abate, Antonio; Feurer, Thomas; Fu, Fan; Avancini, Enrico; Löckinger, Johannes; Reinhard, Patrick; Zakeeruddin, Shaik M; Grätzel, Michael; Buecheler, Stephan; Tiwari, Ayodhya N

    2015-07-16

    A promising way to enhance the efficiency of CIGS solar cells is by combining them with perovskite solar cells in tandem devices. However, so far, such tandem devices had limited efficiency due to challenges in developing NIR-transparent perovskite top cells, which allow photons with energy below the perovskite band gap to be transmitted to the bottom cell. Here, a process for the fabrication of NIR-transparent perovskite solar cells is presented, which enables power conversion efficiencies up to 12.1% combined with an average sub-band gap transmission of 71% for photons with wavelength between 800 and 1000 nm. The combination of a NIR-transparent perovskite top cell with a CIGS bottom cell enabled a tandem device with 19.5% efficiency, which is the highest reported efficiency for a polycrystalline thin film tandem solar cell. Future developments of perovskite/CIGS tandem devices are discussed and prospects for devices with efficiency toward and above 27% are given.

  11. Counter-Rotating Tandem Motor Drilling System

    Energy Technology Data Exchange (ETDEWEB)

    Kent Perry

    2009-04-30

    Gas Technology Institute (GTI), in partnership with Dennis Tool Company (DTC), has worked to develop an advanced drill bit system to be used with microhole drilling assemblies. One of the main objectives of this project was to utilize new and existing coiled tubing and slimhole drilling technologies to develop Microhole Technology (MHT) so as to make significant reductions in the cost of E&P down to 5000 feet in wellbores as small as 3.5 inches in diameter. This new technology was developed to work toward the DOE's goal of enabling domestic shallow oil and gas wells to be drilled inexpensively compared to wells drilled utilizing conventional drilling practices. Overall drilling costs can be lowered by drilling a well as quickly as possible. For this reason, a high drilling rate of penetration is always desired. In general, high drilling rates of penetration (ROP) can be achieved by increasing the weight on bit and increasing the rotary speed of the bit. As the weight on bit is increased, the cutting inserts penetrate deeper into the rock, resulting in a deeper depth of cut. As the depth of cut increases, the amount of torque required to turn the bit also increases. The Counter-Rotating Tandem Motor Drilling System (CRTMDS) was planned to achieve high rate of penetration (ROP) resulting in the reduction of the drilling cost. The system includes two counter-rotating cutter systems to reduce or eliminate the reactive torque the drillpipe or coiled tubing must resist. This would allow the application of maximum weight-on-bit and rotational velocities that a coiled tubing drilling unit is capable of delivering. Several variations of the CRTDMS were designed, manufactured and tested. The original tests failed leading to design modifications. Two versions of the modified system were tested and showed that the concept is both positive and practical; however, the tests showed that for the system to be robust and durable, borehole diameter should be substantially larger

  12. Dosimetric comparison of tandem and Ovoids vs. tandem and ring for intracavitary gynecologic applications.

    Science.gov (United States)

    Levin, Daphne; Menhel, Janna; Rabin, Tanya; Pfeffer, M Raphael; Symon, Zvi

    2008-01-01

    We evaluated dosimetric differences in tandem and ovoid (TO) and tandem and ring (TR) gynecologic brachytherapy applicators. Seventeen patients with cervical cancer (Stages II-IV) receiving 3 high-dose-rate (HDR) brachytherapy applications (both TO and TR) were studied. Patients underwent computed tomography (CT) scans with contrast in bladder, and were prescribed 8 Gy to ICRU points A, with additional optimization goals of maintaining the pear-shaped dose distribution and minimizing bladder and rectum doses. Bladder and rectum point doses, mean, and maximum doses were calculated. Total treatment time and volumes treated to 95%, 85%, 50%, and 20% or the prescription dose were compared. There were no significant differences between TO and TR applicators in doses to prescription points or critical organs. However, there were significant differences (p < 0.001) between the applicators in treated volumes and total treatment time. The TO treated larger volumes over a longer time. Within each patient, when the applicators were compared, treated volumes were also found to be significantly different (p < 0.01, chi(2)). Our results demonstrate that the 2 applicators, while delivering the prescribed dose to points A and keeping critical organ doses below tolerance, treat significantly different volumes. It is unclear if this difference is clinically meaningful. TO applicators may be treating surrounding healthy tissue unnecessarily, or TR applicators may be underdosing tumor tissue. Further investigation with appropriate imaging modalities is required for accurate delineation of target volumes. Clearly, the TO and TR are not identical, and should not be used interchangeably without further study.

  13. Tandem photovoltaic solar cells and increased solar energy conversion efficiency

    Science.gov (United States)

    Loferski, J. J.

    1976-01-01

    Tandem photovoltaic cells, as proposed by Jackson (1955) to increase the efficiency of solar energy conversion, involve the construction of a system of stacked p/n homojunction photovoltaic cells composed of different semiconductors. It had been pointed out by critics, however, that the total power which could be extracted from the cells in the stack placed side by side was substantially greater than the power obtained from the stacked cells. A reexamination of the tandem cell concept in view of the development of the past few years is conducted. It is concluded that the use of tandem cell systems in flat plate collectors, as originally envisioned by Jackson, may yet become feasible as a result of the development of economically acceptable solar cells for large scale terrestrial power generation.

  14. Flatness and Profile Integration Control Model for Tandem Cold Mills

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    Using the effective matrix methods of flatness and profile control synthetically, the flatness and profile in- tegration control scheme for tandem cold mills is built in order to increase flatness and profile control precision of tan- dem cold mills. Corresponding control strategies are adopted for various control objectives of different stands and the coordination control strategies of various stands are given, which makes the on-line flatness control cooperate with on-line profile control and implements the parallel control of different stands. According to the measured flatness and profile data of some 1550 mm tandem cold mills, the control scheme is verified and the result indicates that the scheme has high flatness and profile control precision with steady and reliable control process. A new way and method is supplied for researching shade control of tandem cold mills.

  15. Tandem photovoltaic solar cells and increased solar energy conversion efficiency

    Science.gov (United States)

    Loferski, J. J.

    1976-01-01

    Tandem photovoltaic cells, as proposed by Jackson (1955) to increase the efficiency of solar energy conversion, involve the construction of a system of stacked p/n homojunction photovoltaic cells composed of different semiconductors. It had been pointed out by critics, however, that the total power which could be extracted from the cells in the stack placed side by side was substantially greater than the power obtained from the stacked cells. A reexamination of the tandem cell concept in view of the development of the past few years is conducted. It is concluded that the use of tandem cell systems in flat plate collectors, as originally envisioned by Jackson, may yet become feasible as a result of the development of economically acceptable solar cells for large scale terrestrial power generation.

  16. A periodic table of symmetric tandem mismatches in RNA.

    Science.gov (United States)

    Wu, M; McDowell, J A; Turner, D H

    1995-03-14

    The stabilities and structures of a series of RNA octamers containing symmetric tandem mismatches were studied by UV melting and imino proton NMR. The free energy increments for tandem mismatch formation are found to depend upon both mismatch sequence and adjacent base pairs. The observed sequence dependence of tandem mismatch stability is UGGU > GUUG > GAAG > or = AGGA > UUUU > CAAC > or = CUUC approximately UCCU approximately CCCC approximately ACCA approximately AAAA, and the closing base pair dependence is 5'G3'C > 5'C3'G > 5'U3'A approximately 5'A3'U. These results differ from expectations based on models used in RNA folding algorithms and from the sequence dependence observed for folding of RNA hairpins. Imino proton NMR results indicate the sequence dependence is partially due to hydrogen bonding within mismatches.

  17. Highly Loaded Fan by Using Tandem Cascade Rotor Blade

    Science.gov (United States)

    Hasegawa, Hiroaki; Suga, Shinya; Matsuoka, Akinori

    For axial flow compressors and fans in the aircraft engines higher pressure ratio is required in order to attain the high thrust engines. In this study, the fan with the tandem cascades was introduced to increase the fan pressure ratio. The use of tandem cascades in the fan allows savings in length and weight and therefore a compact fan could be built. The design of fan with tandem cascades and the fan testing were carried out to develop the high pressure ratio fan for the Air Turbo Ramjet (ATR) propulsion system. The ATR is a combined cycle engine which performs like a turbojet engine at subsonic speeds and a ramjet at supersonic speeds. In particular, high fan pressure ratio contributes to increase the engine thrust during subsonic flight at which the engine does not make use of ram effect. The results of the fan testing indicate that the pressure ratio of 2.2 is achieved in single stage fan.

  18. Status of the LLL tandem-shaped charge designs

    Energy Technology Data Exchange (ETDEWEB)

    Godfrey, C.S.; Jandrisevits, R.A.

    1979-02-22

    Lawrence Livermore Laboratory has been engaged in the design of tandem or multistage shaped charges for several years. Analytical and experimental work that focuses on how several aspects of tandem designs affect the jet characteristics is described. The work demonstrates the effectiveness of analytical methodology to specify liner geometries to achieve jets with controlled velocity gradients and high overall efficiency. It also shows that jet clippers and other ancillary components, along with controlled liner thickness, help make clean breaks between the jet and the slug and facilitate insertion of a second jet. Second-stage initiation and interjet time delays are discussed.

  19. Annual Report of HI-13 Tandem Accelerator in 2013

    Institute of Scientific and Technical Information of China (English)

    KAN; Chao-xin; HU; Yue-ming; BAO; Yi-wen; FAN; Hong-sheng

    2013-01-01

    HI-13 tandem accelerator was running well in 2013,some good works were doing well in maintenance and development.This year the machine has been operated 4 000 hours,and provided beam time 3 100 hours for more than 50 experiment users,the terminal voltage range is from 3 MV to 12.3 MV.1 Operation In 2013,HI-13 tandem accelerator provided 16 kinds of ions.The distribution of beam time versus ion is shown in Fig.1.

  20. A Teoria do Comportamento Planejado (TCP e o Índice de Disposição de Adoção de Produtos e Serviços Baseados em Tecnologia (TRI: Uma Interface Possível?

    Directory of Open Access Journals (Sweden)

    Marcelo de Rezende Pinto

    2010-09-01

    Full Text Available A partir de uma revisão teórica, este ensaio tem por objetivo conduzir uma discussão no sentido de relacionar e buscar identificar interfaces entre a Teoria do Comportamento Planejado (TCP e o Índice de Disposição para Adoção de Produtos e Serviços Baseados em Tecnologia desenvolvido por Parasuraman (2000. Para isso, estruturou-se o trabalho da seguinte forma. De início, são apresentadas algumas discussões acerca do processo decisório do consumidor para embasar a apresentação da Teoria do Comportamento Planejado (TCP. Em seguida, são contempladas discussões referentes ao tema disposição para uso da tecnologia e ao construto prontidão para tecnologia e Índice de Adoção para Tecnologia (TRI. A partir daí, a interface ou a relação entre a TCP e a TRI são questionadas. Por fim, foram elaborados comentários conclusivos, com foco principalmente nas proposições de pesquisas empíricas envolvendo os temas.

  1. A Teoria do Comportamento Planejado (TCP e o Índice de Disposição de Adoção de Produtos e Serviços Baseados em Tecnologia (TRI: Uma Interface Possível?

    Directory of Open Access Journals (Sweden)

    Marcelo de Rezende Pinto

    2010-10-01

    Full Text Available

    A partir de uma revisão teórica, este ensaio tem por objetivo conduzir uma discussão no sentido de relacionar e buscar identificar interfaces entre a Teoria do Comportamento Planejado (TCP e o Índice de Disposição para Adoção de Produtos e Serviços Baseados em Tecnologia desenvolvido por Parasuraman (2000. Para isso, estruturou-se o trabalho da seguinte forma. De início, são apresentadas algumas discussões acerca do processo decisório do consumidor para embasar a apresentação da Teoria do Comportamento Planejado (TCP. Em seguida, são contempladas discussões referentes ao tema disposição para uso da tecnologia e ao construto prontidão para tecnologia e Índice de Adoção para Tecnologia (TRI. A partir daí, a interface ou a relação entre a TCP e a TRI são questionadas. Por fim, foram elaborados comentários conclusivos, com foco principalmente nas proposições de pesquisas empíricas envolvendo os temas.

  2. Tandem neopentyl glycol maltosides (TNMs) for membrane protein stabilisation

    DEFF Research Database (Denmark)

    Bae, Hyoung Eun; Mortensen, Jonas S; Ribeiro, Orquidea

    2016-01-01

    A novel class of detergents, designated tandem neopentyl glycol maltosides (TNMs), were evaluated with four target membrane proteins. The best detergent varied depending on the target, but TNM-C12L and TNM-C11S were notable for their ability to confer increased membrane protein stability compared...

  3. PCR-free digital minisatellite tandem repeat genotyping.

    Science.gov (United States)

    Chen, Yuchao; Seo, Tae Seok

    2011-06-01

    We demonstrated a proof-of-concept for novel minisatellite tandem repeat typing, called PCR-free digital VNTR (variable number tandem repeat) typing, which is composed of three steps: a ligation reaction instead of PCR thermal cycling, magnetic bead-based solid-phase capture for purification, and an elongated sample stacking microcapillary electrophoresis (μCE) for sensitive digital coding of repeat number. We designed a 16-bp fluorescently labeled ligation probe which is complementary to a repeat unit of a biotinylated synthetic template mimicking the human D1S80 VNTR locus and is randomly hybridized with the minisatellite tandem repeats. A quick isothermal ligation reaction was followed to link the adjacent ligation probes on the DNA templates, and then the ligated products were purified by streptavidin-coated magnetic beads. After a denaturing step, a large amount of ligated products whose size difference was equivalent to the repeat unit were released and recovered. Through the elongated sample stacking μCE separation on a microdevice, the fluorescence signal of the ligated products was generated in the electropherogram and the peak number was directly counted which was exactly matched with the repeat number of VNTR locus. We could successfully identify the minisatellite tandem repeat number with only 5 fmol of DNA template in 30 min.

  4. Bio-olefins from unsaturated fatty acids via tandem catalysis

    Science.gov (United States)

    A new catalytic route to bio-olefins from unsaturated fatty acids will be described. At the heart of the process, the catalyst apparently functions in a tandem mode by both dynamically isomerizing the positions of double bonds in an aliphatic chain and, subsequently, decarboxylating specific isomers...

  5. Design considerations for the Tandem Junction Solar Cell

    Science.gov (United States)

    Matzen, W. T.; Carbajal, B. G.; Hardy, R. W.

    1979-01-01

    Structure and operation of the tandem junction cell (TJC) are described. The impact of using only back contacts is discussed. A model is presented which explains operation of the TJC in terms of transistor action. The model is applied to predict TJC performance as a function of physical parameters.

  6. Interim report on the tandem mirror hybrid design study

    Energy Technology Data Exchange (ETDEWEB)

    Moir, R.W. (ed.)

    1979-08-01

    The initial phase of a 2-year design study of a tandem mirror fusion reactor is presented. The following chapters are included: (1) mechanical design of the plant; (2) plasma physics; (3) blanket design; (4) magnet design; (5) injector design; (6) direct convertor design; (7) balance of plant design; (8) fission burner reactor; (9) environment and safety; and (10) economic analysis. (MOW)

  7. Tandem fluid queues fed by homogeneous on-off sources

    NARCIS (Netherlands)

    Scheinhardt, Willem R.W.; Aalto, Samuli

    2000-01-01

    We consider a tandem fluid model with multiple consecutive buffers. The input of buffer j+1 is the output from buffer j, while the first buffer is fed by a, possibly infinite, number of independent homogeneous on–off sources. The sources have exponentially distributed silent periods and generally di

  8. Crux: rapid open source protein tandem mass spectrometry analysis.

    Science.gov (United States)

    McIlwain, Sean; Tamura, Kaipo; Kertesz-Farkas, Attila; Grant, Charles E; Diament, Benjamin; Frewen, Barbara; Howbert, J Jeffry; Hoopmann, Michael R; Käll, Lukas; Eng, Jimmy K; MacCoss, Michael J; Noble, William Stafford

    2014-10-03

    Efficiently and accurately analyzing big protein tandem mass spectrometry data sets requires robust software that incorporates state-of-the-art computational, machine learning, and statistical methods. The Crux mass spectrometry analysis software toolkit ( http://cruxtoolkit.sourceforge.net ) is an open source project that aims to provide users with a cross-platform suite of analysis tools for interpreting protein mass spectrometry data.

  9. Near-optimal switching strategies for a tandem queue

    NARCIS (Netherlands)

    Leeuwen, D. van; Núñez Queija, R.; Boucherie, R.J.; van Dijk, N.M.

    2015-01-01

    Motivated by various applications in logistics, road traffic and production management, we investigate two versions of a tandem queueing model in which the service rate of the first queue can be controlled. The objective is to keep the mean number of jobs in the second queue as low as possible, with

  10. Ultimate performance of polymer: Fullerene bulk heterojunction tandem solar cells

    NARCIS (Netherlands)

    Kotlarski, J.D.; Blom, P.W.M.

    2011-01-01

    We present the model calculations to explore the potential of polymer:fullerene tandem solar cells. As an approach we use a combined optical and electrical device model, where the absorption profiles are used as starting point for the numerical current-voltage calculations. With this model a maximum

  11. Beam optics of the folded tandem ion accelerator at BARC

    Indian Academy of Sciences (India)

    S Santra; P Singh

    2002-07-01

    The beam optics of the 6 MV folded tandem ion accelerator, that has recently been commissioned at Bhabha Atomic Research Centre, Mumbai, is presented. Typical beam trajectories for proton and 12C beams under different conditions, are shown. The constraints on the design due to the use of the infrastructure of the Van de Graaff accelerator, which existed earlier, are discussed.

  12. Tandem, roostes sild ja erinnüsed / Andres Langemets

    Index Scriptorium Estoniae

    Langemets, Andres, 1948-

    2002-01-01

    Arvustus: Tandem. Pegasus on pisut pervers. Tln. : Perioodika, 2002. (Loomingu Raamatukogu ; 1) ; Sild, Ivar. Minu erünnised. Tallinn : LauaPealne, 2002 ; Rooste, Jürgen. Igapäevane Psyhho : kalendaarium et mõista elu / kujund. Mammut. I. k. : Sulemees, 2001

  13. II-IV-V Based Thin Film Tandem Photovoltaic Cell

    Energy Technology Data Exchange (ETDEWEB)

    Newman, Nathan [Arizona State Univ., Mesa, AZ (United States); van Schilfgaarde, Mark [Arizona State Univ., Mesa, AZ (United States)

    2012-10-04

    [Through a combination of theory and experiment that, absent unknown mitigating factors, a tandem cell whose (wide-gap. 1.8 eV) top layer is made of ZnSnP2 and whose (narrow gap, 1.1 eV) bottom layer consisting of ZnGeAs2 are near-ideal materials for a tandem cell. Not only are there gaps optimally adjusted to the solar spectrum, but the two compounds are lattice-matched, and their energy band structure and optical absorption are also near-ideal (they closely resemble that of GaAs). Our first major challenge is to establish that high-quality II-IV-V thin films can be synthesized. We have begun growing and characterizing films of ZnGeAs2 and ZnSnP2, initially grown on Ge substrates (the lattice constant of Ge matches these compounds) by pulsed laser ablation and sputtering. In tandem are theoretical calculations to guide the experiments. The goal is to develop methods that can be used to produce a pair of lattice-matched thin films that will be useful in tandem cells.

  14. Tandem, roostes sild ja erinnüsed / Andres Langemets

    Index Scriptorium Estoniae

    Langemets, Andres, 1948-

    2002-01-01

    Arvustus: Tandem. Pegasus on pisut pervers. Tln. : Perioodika, 2002. (Loomingu Raamatukogu ; 1) ; Sild, Ivar. Minu erünnised. Tallinn : LauaPealne, 2002 ; Rooste, Jürgen. Igapäevane Psyhho : kalendaarium et mõista elu / kujund. Mammut. I. k. : Sulemees, 2001

  15. Tandem chemiluminescence-flow injection analysis for dimethoate determination.

    OpenAIRE

    Catalá Icardo, Mónica; López Paz, José Luis; CHOVES BARÓN, CRISTINA

    2010-01-01

    Ministry of Education and Science [CTM2006-11991] FEDER funds Catalá Icardo, M.; López Paz, JL.; Choves Barón, C. (2010). Tandem chemiluminescence-flow injection analysis for dimethoate determination. Luminescence. 25:235-236. doi:10.1002/bio.1217. Senia 235 236 25

  16. State-dependent importance sampling for a Jackson tandem network

    NARCIS (Netherlands)

    Miretskiy, D.I.; Scheinhardt, W.R.W.; Mandjes, M.R.H.

    2008-01-01

    This paper considers importance sampling as a tool for rare-event simulation. The focus is on estimating the probability of overflow in the downstream queue of a Jacksonian two-node tandem queue – it is known that in this setting ‘traditional’ stateindependent importance-sampling distributions perfo

  17. State-dependent importance sampling for a Jackson tandem network

    NARCIS (Netherlands)

    Miretskiy, D.I.; Scheinhardt, W.R.W.; Mandjes, M.R.H.

    2008-01-01

    This paper considers importance sampling as a tool for rare-event simulation. The focus is on estimating the probability of overflow in the downstream queue of a Jacksonian two-node tandem queue – it is known that in this setting ‘traditional’ state-independent importance-sampling distributions perf

  18. State-dependent importance sampling for a Jackson tandem network

    NARCIS (Netherlands)

    Miretskiy, Denis; Scheinhardt, Werner; Mandjes, Michel

    2010-01-01

    This article considers importance sampling as a tool for rare-event simulation. The focus is on estimating the probability of overflow in the downstream queue of a Jacksonian two-node tandem queue; it is known that in this setting “traditional” state-independent importance-sampling distributions per

  19. State-dependent importance sampling for a Jackson tandem network

    NARCIS (Netherlands)

    D. Miretskiy; W. Scheinhardt; M. Mandjes

    2010-01-01

    This article considers importance sampling as a tool for rare-event simulation. The focus is on estimating the probability of overflow in the downstream queue of a Jacksonian two-node tandem queue; it is known that in this setting "traditional" state-independent importance-sampling distributions per

  20. Monolithic Parallel Tandem Organic Photovoltaic Cell with Transparent Carbon Nanotube Interlayer

    Science.gov (United States)

    Tanaka, S.; Mielczarek, K.; Ovalle-Robles, R.; Wang, B.; Hsu, D.; Zakhidov, A. A.

    2009-01-01

    We demonstrate an organic photovoltaic cell with a monolithic tandem structure in parallel connection. Transparent multiwalled carbon nanotube sheets are used as an interlayer anode electrode for this parallel tandem. The characteristics of front and back cells are measured independently. The short circuit current density of the parallel tandem cell is larger than the currents of each individual cell. The wavelength dependence of photocurrent for the parallel tandem cell shows the superposition spectrum of the two spectral sensitivities of the front and back cells. The monolithic three-electrode photovoltaic cell indeed operates as a parallel tandem with improved efficiency.

  1. Monolithic Parallel Tandem Organic Photovoltaic Cell with Transparent Carbon Nanotube Interlayer

    Science.gov (United States)

    Tanaka, S.; Mielczarek, K.; Ovalle-Robles, R.; Wang, B.; Hsu, D.; Zakhidov, A. A.

    2009-01-01

    We demonstrate an organic photovoltaic cell with a monolithic tandem structure in parallel connection. Transparent multiwalled carbon nanotube sheets are used as an interlayer anode electrode for this parallel tandem. The characteristics of front and back cells are measured independently. The short circuit current density of the parallel tandem cell is larger than the currents of each individual cell. The wavelength dependence of photocurrent for the parallel tandem cell shows the superposition spectrum of the two spectral sensitivities of the front and back cells. The monolithic three-electrode photovoltaic cell indeed operates as a parallel tandem with improved efficiency.

  2. Fully integrated, fully automated generation of short tandem repeat profiles

    Science.gov (United States)

    2013-01-01

    Background The generation of short tandem repeat profiles, also referred to as ‘DNA typing,’ is not currently performed outside the laboratory because the process requires highly skilled technical operators and a controlled laboratory environment and infrastructure with several specialized instruments. The goal of this work was to develop a fully integrated system for the automated generation of short tandem repeat profiles from buccal swab samples, to improve forensic laboratory process flow as well as to enable short tandem repeat profile generation to be performed in police stations and in field-forward military, intelligence, and homeland security settings. Results An integrated system was developed consisting of an injection-molded microfluidic BioChipSet cassette, a ruggedized instrument, and expert system software. For each of five buccal swabs, the system purifies DNA using guanidinium-based lysis and silica binding, amplifies 15 short tandem repeat loci and the amelogenin locus, electrophoretically separates the resulting amplicons, and generates a profile. No operator processing of the samples is required, and the time from swab insertion to profile generation is 84 minutes. All required reagents are contained within the BioChipSet cassette; these consist of a lyophilized polymerase chain reaction mix and liquids for purification and electrophoretic separation. Profiles obtained from fully automated runs demonstrate that the integrated system generates concordant short tandem repeat profiles. The system exhibits single-base resolution from 100 to greater than 500 bases, with inter-run precision with a standard deviation of ±0.05 - 0.10 bases for most alleles. The reagents are stable for at least 6 months at 22°C, and the instrument has been designed and tested to Military Standard 810F for shock and vibration ruggedization. A nontechnical user can operate the system within or outside the laboratory. Conclusions The integrated system represents the

  3. Traditional learning and problem-based learning: self-perception of preparedness for internship Método tradicional e aprendizado baseado em problemas: autopercepção do preparo para o internato

    Directory of Open Access Journals (Sweden)

    Laís Pereira Bueno Millan

    2012-10-01

    Full Text Available OBJECTIVE: This study aims to evaluate Pontificia Universidade Católica de São Paulo (PUC-SP medical students' perception of their preparedness to attend the internship course by comparing students who entered the internship in 2009, who were taught according to the traditional learning method, and those who entered the internship in 2010, who were taught according to the new method, i.e. problem-based learning (PBL. METHODS: 50 traditional learning method students answered a standard Lickert scale questionnaire upon entering internship in 2009. In 2010, the process was repeated with PBL students. The questionnaire was based upon the Preparation for Hospital Practice Questionnaire. This questionnaire was evaluated by professors from three medical schools in Brazil regarding its applicability. The original questions were classified according to the importance these professors attributed to them, and less important questions were removed. Scores obtained from the Student's t-test were considered significant with p OBJETIVO: Este estudo visa avaliar a percepção dos alunos de Medicina da Pontifícia Universidade Católica de São Paulo (PUC-SP quanto ao seu preparo para cursar o internato, comparando os alunos que ingressaram no internato em 2009, no método tradicional, e aqueles que o iniciaram em 2010, no novo método, o aprendizado baseado em problemas (ABP. MÉTODOS: Aplicou-se um questionário padronizado, respondido através de uma escala de Lickert, a cinquenta alunos do método tradicional, no início do internato, em 2009. Em 2010, o processo foi repetido com os alunos do novo método. O questionário foi baseado no Preparation for Hospital Practice Questionnaire. Esse questionário foi avaliado, no Brasil, quanto à sua aplicabilidade, por professores de três cursos de Medicina. As questões originais foram classificadas de acordo com a importância atribuída por eles e as consideradas menos relevantes foram retiradas. Compararam

  4. O novo modelo da cascata de coagulação baseado nas superfícies celulares e suas implicações A cell-based model of coagulation and its implications

    Directory of Open Access Journals (Sweden)

    Cláudia Natália Ferreira

    2010-01-01

    Full Text Available O conceito da cascata da coagulação descreve as interações bioquímicas dos fatores da coagulação, entretanto, tem falhado como um modelo do processo hemostático in vivo. A hemostasia requer a formação de um tampão de plaquetas e fibrina no local da lesão vascular, bem como a permanência de substâncias procoagulantes ativadas nesse processo no sítio da lesão. O controle da coagulação sanguínea é realizado por meio de reações procoagulantes em superfícies celulares específicas e localizadas, evitando a propagação da coagulação no sistema vascular. Uma análise crítica do papel das células no processo hemostático permite a construção de um modelo da coagulação que melhor explica hemorragias e tromboses in vivo. O modelo da coagulação baseado em superfícies celulares substitui a tradicional hipótese da "cascata" e propõe a ativação do processo de coagulação sobre diferentes superfícies celulares em quatro fases que se sobrepõem: iniciação, amplificação, propagação e finalização. O modelo baseado em superfícies celulares permite um maior entendimento de como a hemostasia funciona in vivo e esclarece o mecanismo fisiopatológico de certos distúrbios da coagulação.The concept of a coagulation cascade describes the biochemical interactions of the coagulation factors, but it is flawed as a model of the in vivo hemostatic process. Hemostasis requires both platelet and fibrin plug formation at the site of vessel injury and that the procoagulant substances activated in this process remain at the site of injury. This control of blood coagulation is accomplished as the procoagulant reactions only exist on specific cell surfaces to keep coagulation from spreading throughout the vascular system. A model of coagulation that better explains bleeding and thrombosis in vivo created after considering the critical role of cells. The cellbased model of hemostasis replaces the traditional "cascade" hypothesis

  5. Proposta de Implementação do Custeio Baseado em Atividades na Gestão de Serviços Odontológicos = Implementation proposal of activity-based costing in the management of dental services

    Directory of Open Access Journals (Sweden)

    Karyn de Castro Serratine

    2013-03-01

    Full Text Available O artigo tem por objetivo estruturar uma proposta de implementação do custeio baseado em atividades na gestão de serviços odontológicos. Foi realizada uma pesquisa descritiva, por meio de um estudo de caso, com abordagem predominantemente qualitativa. O estudo inicia com uma incursão teórica nos fundamentos que sustentam o estudo empírico, abordando a importância da gestão estratégica de custos, o custeio baseado em atividades – ABC e a utilização do ABC em empresas de saúde. Após, são apresentados os procedimentos metodológicos adotados. Na sequência, discute-se a proposta realizada. A proposta de implementação do ABC contempla quatro macroetapas: identificação das atividades; atribuição dos custos às atividades; identificação dos objetos de custos; e atribuição dos custos das atividades aos objetos de custos. Foram selecionados seis procedimentos odontológicos prestados: avaliação, profilaxia, restauração, endodontia, exodontia e coroa protética porcelana. A escolha justifica-se por se tratar dos procedimentos mais representativos em termos de ocorrência e de faturamento. Além da proposta de implementação do ABC, fez-se a análise dos custos diretos de cada objeto de custo. Os custos diretos identificados referem-se aos materiais utilizados e ao processo de esterilização realizado. The goal of this article is to structure an implementation proposal of activity-based costing in the management of dental services. A descriptive research was carried out through a case study with a predominantly qualitative approach. The study begins with a foray into the theoretical foundations that support the empirical study addressing the importance of strategic cost management, activity-based costing - ABC and the use of ABC in healthcare companies. Then, methodological procedures are presented and the proposal made is discussed. The implementation proposal of ABC comprises four macro-steps: identification of

  6. Ensino baseado em simulação na formação continuada de médicos: análise das percepções de alunos e professores de um Hospital do Rio de Janeiro

    Directory of Open Access Journals (Sweden)

    Alessandra Sá Simões Dourado

    Full Text Available Nos últimos anos, o ensino baseado em simulação (EBS tem sido cada vez mais utilizado na educação em saúde e especialmente na educação médica. Este estudo teve como objetivo investigar as potencialidades e desafios do EBS no contexto de um curso de formação continuada de médicos: Curso em Ressuscitação Cardiopulmonar (RCP Avançado. A coleta de dados foi realizada por meio de observação de campo, entrevistas com professores e aplicação de questionários aos alunos do curso. Para análise das percepções dos participantes, adotou-se a análise de conteúdo temática. Os resultados apontaram quatro principais potencialidades e desafios do EBS para a formação médica: articulação entre teoria e prática; o erro como oportunidade de aprendizagem; relação entre mundo virtual e mundo real; fortalecimento do trabalho em equipe. Acredita-se que este trabalho possa contribuir com a discussão acerca da utilização do EBS na educação médica, assim como indicar pontos favoráveis e desafios de sua implementação, revelando a importância de pesquisas que aprofundem as questões pedagógicas envolvidas no percurso de aplicação desta metodologia.

  7. A TRADUÇÃO PARA O INGLÊS DO LÉXICO TABUIZADO NO UNIVERSO ERÓTICO MAIRUM: UM ESTUDO BASEADO NO CORPUS DA OBRA MAÍRA DE DARCY RIBEIRO

    Directory of Open Access Journals (Sweden)

    Talita Serpa

    2014-11-01

    Full Text Available Este artigo tem por objetivo observar o processo tradutório na direção português à inglês no que concerne às metáforas das unidades léxicas específicas referentes às zonas erógenas e ao ato sexual na contextualização da produção literária da obra Maíra (1978 de Darcy Ribeiro e na respectiva tradução, Maíra (1984, realizada por Goodland e Colchie. Para tanto, apoiamo-nos em uma abordagem interdisciplinar que associa o arcabouço dos Estudos do Léxico (BIDERMAN, 1996; LAKOFF & JOHNSON, 2002; ORSI, 2007, 2009; ORSI & ZAVAGLIA, 2007, 2012; PRETI, 1984; XATARA, 2002, 2004, dos Estudos da Tradução Baseados em Corpus (BAKER, 1993, 1995; CAMARGO, 2005, da Linguística de Corpus (TYMOCZKO, 1998; BERBER SARDINHA, 2004 e, em parte, da Terminologia (COELHO, 2003; BARROS, 2004; FAULSTICH, 2004. Quanto à metodologia, utilizamos as ferramentas, WordList e Concord, disponibilizadas pelo programa WordSmith Tools, as quais nos proporcionaram os recursos para o levantamento e a exploração dos dados. Desse modo, procuramos verificar o valor concedido à linguagem erótico-obscena na construção literário-textual darcyniana e analisar a reformulação lexical tabuizada em língua inglesa. Nesse sentido, tencionamos refletir sobre as traduções dessas unidades lexicais consideradas socialmente desprestigiadas, assim como oferecer possíveis subsídios para tradutores, linguistas, literatos e cientistas sociais.

  8. A TRADUÇÃO PARA O INGLÊS DO LÉXICO TABUIZADO NO UNIVERSO ERÓTICO MAIRUM: UM ESTUDO BASEADO NO CORPUS DA OBRA MAÍRA DE DARCY RIBEIRO

    Directory of Open Access Journals (Sweden)

    Talita Serpa

    2014-07-01

    Full Text Available Este artigo tem por objetivo observar o processo tradutório na direção português à inglês no que concerne às metáforas das unidades léxicas específicas referentes às zonas erógenas e ao ato sexual na contextualização da produção literária da obra Maíra (1978 de Darcy Ribeiro e na respectiva tradução, Maíra (1984, realizada por Goodland e Colchie. Para tanto, apoiamo-nos em uma abordagem interdisciplinar que associa o arcabouço dos Estudos do Léxico (BIDERMAN, 1996; LAKOFF & JOHNSON, 2002; ORSI, 2007, 2009; ORSI & ZAVAGLIA, 2007, 2012; PRETI, 1984; XATARA, 2002, 2004, dos Estudos da Tradução Baseados em Corpus (BAKER, 1993, 1995; CAMARGO, 2005, da Linguística de Corpus (TYMOCZKO, 1998; BERBER SARDINHA, 2004 e, em parte, da Terminologia (COELHO, 2003; BARROS, 2004; FAULSTICH, 2004. Quanto à metodologia, utilizamos as ferramentas, WordList e Concord, disponibilizadas pelo programa WordSmith Tools, as quais nos proporcionaram os recursos para o levantamento e a exploração dos dados. Desse modo, procuramos verificar o valor concedido à linguagem erótico-obscena na construção literário-textual darcyniana e analisar a reformulação lexical tabuizada em língua inglesa. Nesse sentido, tencionamos refletir sobre as traduções dessas unidades lexicais consideradas socialmente desprestigiadas, assim como oferecer possíveis subsídios para tradutores, linguistas, literatos e cientistas sociais.

  9. Esforços de integração em projetos radicais e incrementais de desenvolvimento de novos produtos baseados na biodiversidade: estudo de caso em empresa do setor de biotecnologia

    Directory of Open Access Journals (Sweden)

    Tiago Ribeiro de Araújo

    Full Text Available Resumo Pesquisas recentes em gestão do processo de desenvolvimento de produtos têm apresentado resultados divergentes sobre a necessidade de esforços de integração interfuncional. Estudos demonstram que aspectos contingenciais e o grau de inovação incorporado aos projetos de produtos são elementos que devem ser considerados nesses esforços de integração. O objetivo deste trabalho foi analisar como ocorrem os esforços de integração em projetos de inovação incremental e radical no desenvolvimento de novos produtos. Realizou-se estudo de caso único em empresa que desenvolve continuamente tecnologias e produtos baseados na biodiversidade brasileira. Dentre os principais resultados, notou-se que, devido a sua maior complexidade tecnológica, os projetos de inovação radical demandam intensa integração interfuncional, e que a distância física do departamento de P&D também demonstrou ser prática que gera resultados positivos para o desenvolvimento desse tipo de projeto. Por outro lado, observou-se que a co-localização é benéfica à interação entre as equipes no caso dos projetos de inovação incremental. Outro resultado observado foi a aplicação de tecnologias de informação, tais como o sistema Customer Relationship Management, como mecanismos formais de auxílio à integração interfuncional em projetos de inovação radical e incremental.

  10. A Tandem Valve, a unique complication of TAVR

    Directory of Open Access Journals (Sweden)

    Srinivasan Sattiraju

    2016-02-01

    Full Text Available , MD1*,, MD1,, MD1,, MD2, MD2,, MD, PhD3 1. Division of Cardiology, Carle Heart and Vascular Institute, Carle Hospital, Urbana, IL 2. Cardiovascular Surgery, Carle Heart and Vascular Institute, Carle Hospital, Urbana, IL 3. Division of Cardiology, University of Minnesota Medical Center, Minneapolis, MN Received: 11-1-16, Reviewed: 22-1-16, Accepted: 26-1-16 Keywords: Transcatheter aortic valve replacement, TAVR, Valve embolisation DOI: ABSTRACT We report a unique complication of transcatheter aortic valve replacement (TAVR in which there is mechanical entrapment of two Edward Sapien valves. The tandem valve con guration created a high gradient across the valves stuck in tandem. The images and videos in this case capture ndings that underscore the complexity of interaction between two prosthetic valves. We believe this case serves a high teaching value for physicians taking care of patients with aortic stenosis managed with TAVR approach.

  11. Tandem mirror and field-reversed mirror experiments

    Energy Technology Data Exchange (ETDEWEB)

    Coensgen, F.H.; Simonen, T.C.; Turner, W.C.

    1979-08-21

    This paper is largely devoted to tandem mirror and field-reversed mirror experiments at the Lawrence Livermore Laboratory (LLL), and briefly summarizes results of experiments in which field-reversal has been achieved. In the tandem experiment, high-energy, high-density plasmas (nearly identical to 2XIIB plasmas) are located at each end of a solenoid where plasma ions are electrostatically confined by the high positive poentials arising in the end plug plasma. End plug ions are magnetically confined, and electrons are electrostatically confined by the overall positive potential of the system. The field-reversed mirror reactor consists of several small field-reversed mirror plasmas linked together for economic reasons. In the LLL Beta II experiment, generation of a field-reversed plasma ring will be investigated using a high-energy plasma gun with a transverse radial magnetic field. This plasma will be further heated and sustained by injection of intense, high-energy neutral beams.

  12. Single P-N junction tandem photovoltaic device

    Science.gov (United States)

    Walukiewicz, Wladyslaw; Ager, III, Joel W.; Yu, Kin Man

    2011-10-18

    A single P-N junction solar cell is provided having two depletion regions for charge separation while allowing the electrons and holes to recombine such that the voltages associated with both depletion regions of the solar cell will add together. The single p-n junction solar cell includes an alloy of either InGaN or InAlN formed on one side of the P-N junction with Si formed on the other side in order to produce characteristics of a two junction (2J) tandem solar cell through only a single P-N junction. A single P-N junction solar cell having tandem solar cell characteristics will achieve power conversion efficiencies exceeding 30%.

  13. Graphene based integrated tandem supercapacitors fabricated directly on separators

    KAUST Repository

    Chen, Wei

    2015-04-09

    It is of great importance to fabricate integrated supercapacitors with extended operation voltages as high energy density storage devices. In this work, we develop a novel direct electrode deposition on separator (DEDS) process to fabricate graphene based integrated tandem supercapacitors for the first time. The DEDS process generates compact graphene-polyaniline electrodes directly on the separators to form integrated supercapacitors. The integrated graphene-polyaniline tandem supercapacitors demonstrate ultrahigh volumetric energy density of 52.5 Wh L^(−1) at power density of 6037 W L^(−1) and excellent gravimetric energy density of 26.1 Wh kg^(−1) at power density of 3002 W kg^(−1) with outstanding electrochemical stability for over 10000 cycles. This study show great promises for the future development of integrated energy storage devices.

  14. Protein identification using nano liquid chromatography-tandem mass spectrometry.

    Science.gov (United States)

    Negroni, Luc

    2007-01-01

    Tandem mass spectrometry is an efficient technique for the identification of peptides on the basis of their fragmentation pattern (MS/MS scan). It can generate individual spectra for each peptide, thereby creating a powerful tool for protein identification on the basis of peptide characterization. This important advance in automatic data acquisition has allowed an efficient association between liquid chromatography and tandem mass spectrometry, and the use of nanocolumns and nanoelectrospray ionization has dramatically increased the efficiency of this method. Now large sets of peptides can be identified at a femtomole level. At the end of the process, batch processing of the MS/MS spectra produces peptide lists that identify purified proteins or protein mixtures with high confidence.

  15. Tandem Repeats in Proteins : Prediction Algorithms and Biological Role

    Directory of Open Access Journals (Sweden)

    Marco ePellegrini

    2015-09-01

    Full Text Available Tandem repetitions in protein sequence and structure is a fascinatingsubject of research which has been a focus of study since the late 1990's.In this survey we give an overviewon the multi-faceted aspects of research on protein tandem repeats textcolor{red}{(PTR for short}, including prediction algorithms, databases,early classification efforts, mechanisms of PTR formation and evolution, and synthetic PTR design.We also touch on the rather open issue of the relationship between PTRand flexibility (or disorder in proteins.Detection of PTR either from protein sequence or structure data is challenging due to inherent high (biological signal-to-noise ratio that is a key feature of this problem.As early in silico analytic tools have been key enablers for starting this field of study, we expect that current and future algorithmic and statistical breakthroughs willhave a high impact on the investigations of the biological role of PTR.

  16. Single P-N junction tandem photovoltaic device

    Science.gov (United States)

    Walukiewicz, Wladyslaw [Kensington, CA; Ager, III, Joel W.; Yu, Kin Man [Lafayette, CA

    2012-03-06

    A single P-N junction solar cell is provided having two depletion regions for charge separation while allowing the electrons and holes to recombine such that the voltages associated with both depletion regions of the solar cell will add together. The single p-n junction solar cell includes an alloy of either InGaN or InAlN formed on one side of the P-N junction with Si formed on the other side in order to produce characteristics of a two junction (2J) tandem solar cell through only a single P-N junction. A single P-N junction solar cell having tandem solar cell characteristics will achieve power conversion efficiencies exceeding 30%.

  17. A Brief Review of Short Tandem Repeat Mutation

    Institute of Scientific and Technical Information of China (English)

    Hao Fan; Jia-You Chu

    2007-01-01

    Short tandem repeats (STRs) are short tandemly repeated DNA sequences that involve a repetitive unit of 1-6 bp. Because of their polymorphisms and high mutation rates, STRs are widely used in biological research. Strand-slippage replication is the predominant mutation mechanism of STRs, and the stepwise mutation model is regarded as the main mutation model. STR mutation rates can be influenced by many factors. Moreover, some trinucleotide repeats are associated with human neurodegenerative diseases. In order to deepen our knowledge of these diseases and broaden STR application, it is essential to understand the STR mutation process in detail. In this review, we focus on the current known information about STR mutation.

  18. Summary of results from the Tandem Mirror Experiment (TMX)

    Energy Technology Data Exchange (ETDEWEB)

    Simonen, T.C. (ed.)

    1981-02-26

    This report summarizes results from the successful experimental operation of the Tandem Mirror Experiment (TMX) over the period October 1978 through September 1980. The experimental program, summarized by the DOE milestones given in Table 1-1, had three basic phases: (1) an 8-month checkout period, October 1978 through May 1979; (2) a 6-month initial period of operation, June through November 1979, during which the basic principles of the tandem configuration were demonstrated (i.e., plasma confinement was improved over that of a single-cell mirror); and (3) a 10-month period, December 1979 through September 1980, during which the initial TMX results were corroborated by additional diagnostic measurements and many detailed physics investigations were carried out. This report summarizes the early results, presents results of recent data analysis, and outlines areas of ongoing research and data analysis which will be reported in future journal publications.

  19. Isotope effects in a multicusp tandem ion source

    Energy Technology Data Exchange (ETDEWEB)

    Graham, W.G. (Department of Pure and Applied Physics, Queen' s University, Belfast BT7 1NN (Northern Ireland))

    1992-10-05

    Measurements of plasma parameters, including electron density, electron energy distribution function (eedf), and negative ion density, have been made in the driver and extractor regions of a multicusp tandem ion source. Here results which focus on comparing operation in hydrogen and deuterium are presented. Several isotope effects are evident. In particular, for the same operating conditions, the electron density is found to be higher in deuterium than in hydrogen while the negative ion density is consistently lower.

  20. A device model for the tandem junction solar cell

    Science.gov (United States)

    Matzen, W. T.; Chiang, S. Y.; Carbajal, B. G.

    1979-01-01

    A conceptual device model has been developed to explain operation of the tandem junction cell (TJC) when back contacts only are used. Operation and parameters of the cell are explained by transistor action. Experimental observations are presented which confirm that current is collected for carrier generation in the front uncontacted n(plus) region. The model should be useful as a guideline to optimize the TJC by application of transistor design principles.

  1. Interpretation of Tandem Mass Spectrometry (MSMS) Spectra for Peptide Analysis

    DEFF Research Database (Denmark)

    Hjernø, Karin; Højrup, Peter

    2015-01-01

    The aim of this chapter is to give a short introduction to peptide analysis by mass spectrometry (MS) and interpretation of fragment mass spectra. Through examples and guidelines we demonstrate how to understand and validate search results and how to perform de novo sequencing based on the often...... very complex fragmentation pattern obtained by tandem mass spectrometry (also referred to as MSMS). The focus is on simple rules for interpretation of MSMS spectra of tryptic as well as non-tryptic peptides....

  2. Tandem planet formation for solar system-like planetary systems

    Directory of Open Access Journals (Sweden)

    Yusuke Imaeda

    2017-03-01

    Full Text Available We present a new united theory of planet formation, which includes magneto-rotational instability (MRI and porous aggregation of solid particles in a consistent way. We show that the “tandem planet formation” regime is likely to result in solar system-like planetary systems. In the tandem planet formation regime, planetesimals form at two distinct sites: the outer and inner edges of the MRI suppressed region. The former is likely to be the source of the outer gas giants, and the latter is the source for the inner volatile-free rocky planets. Our study spans disks with a various range of accretion rates, and we find that tandem planet formation can occur for M˙=10−7.3-10−6.9M⊙yr−1. The rocky planets form between 0.4–2 AU, while the icy planets form between 6–30 AU; no planets form in 2–6 AU region for any accretion rate. This is consistent with the gap in the solid component distribution in the solar system, which has only a relatively small Mars and a very small amount of material in the main asteroid belt from 2–6 AU. The tandem regime is consistent with the idea that the Earth was initially formed as a completely volatile-free planet. Water and other volatile elements came later through the accretion of icy material by occasional inward scattering from the outer regions. Reactions between reductive minerals, such as schreibersite (Fe3P, and water are essential to supply energy and nutrients for primitive life on Earth.

  3. Status report on the folded tandem ion accelerator at BARC

    Indian Academy of Sciences (India)

    P Singh; S K Gupta; M J Kansara; A Agarwal; S Santra; Rajesh Kumar; A Basu; P Sapna; S P Sarode; N B V Subrahmanyam; J P Bhatt; P J Raut; S S Pol; P V Bhagwat; S Kailas; B K Jain

    2002-11-01

    The folded tandem ion accelerator (FOTIA) facility set up at BARC has become operational. At present, it is used for elemental analysis studies using the Rutherford backscattering technique. The beams of 1H, 7Li, 12C, 16O and 19F have been accelerated up to terminal voltages of about 3 MV and are available for experiments. The terminal voltage is stable within ± 2 kV. In this paper, present status of the FOTIA and future plans are discussed.

  4. Annual Report of HI-13 Tandem Accelerator in 2012

    Institute of Scientific and Technical Information of China (English)

    KAN; Chao-xin; HU; Yue-ming; BAO; Yi-wen; FAN; Hong-sheng

    2012-01-01

    <正>HI-13 tandem accelerator was running well in 2012, some good works were doing well in maintenance and development. This year the machine has been operated 3 600 h, and provided beam time 3 200 h for more than 40 experiment users, the terminal voltage range is from 3 MV to 12 MV. From 1988 to June of 2012, the machine had been running safety for 100 000 h.

  5. Perovskite-perovskite tandem photovoltaics with optimized band gaps

    Science.gov (United States)

    Eperon, Giles E.; Leijtens, Tomas; Bush, Kevin A.; Prasanna, Rohit; Green, Thomas; Wang, Jacob Tse-Wei; McMeekin, David P.; Volonakis, George; Milot, Rebecca L.; May, Richard; Palmstrom, Axel; Slotcavage, Daniel J.; Belisle, Rebecca A.; Patel, Jay B.; Parrott, Elizabeth S.; Sutton, Rebecca J.; Ma, Wen; Moghadam, Farhad; Conings, Bert; Babayigit, Aslihan; Boyen, Hans-Gerd; Bent, Stacey; Giustino, Feliciano; Herz, Laura M.; Johnston, Michael B.; McGehee, Michael D.; Snaith, Henry J.

    2016-11-01

    We demonstrate four- and two-terminal perovskite-perovskite tandem solar cells with ideally matched band gaps. We develop an infrared-absorbing 1.2-electron volt band-gap perovskite, FA0.75Cs0.25Sn0.5Pb0.5I3, that can deliver 14.8% efficiency. By combining this material with a wider-band gap FA0.83Cs0.17Pb(I0.5Br0.5)3 material, we achieve monolithic two-terminal tandem efficiencies of 17.0% with >1.65-volt open-circuit voltage. We also make mechanically stacked four-terminal tandem cells and obtain 20.3% efficiency. Notably, we find that our infrared-absorbing perovskite cells exhibit excellent thermal and atmospheric stability, not previously achieved for Sn-based perovskites. This device architecture and materials set will enable “all-perovskite” thin-film solar cells to reach the highest efficiencies in the long term at the lowest costs.

  6. The mechanics and behavior of cliff swallows during tandem flights.

    Science.gov (United States)

    Shelton, Ryan M; Jackson, Brandon E; Hedrick, Tyson L

    2014-08-01

    Cliff swallows (Petrochelidon pyrrhonota) are highly maneuverable social birds that often forage and fly in large open spaces. Here we used multi-camera videography to measure the three-dimensional kinematics of their natural flight maneuvers in the field. Specifically, we collected data on tandem flights, defined as two birds maneuvering together. These data permit us to evaluate several hypotheses on the high-speed maneuvering flight performance of birds. We found that high-speed turns are roll-based, but that the magnitude of the centripetal force created in typical maneuvers varied only slightly with flight speed, typically reaching a peak of ~2 body weights. Turning maneuvers typically involved active flapping rather than gliding. In tandem flights the following bird copied the flight path and wingbeat frequency (~12.3 Hz) of the lead bird while maintaining position slightly above the leader. The lead bird turned in a direction away from the lateral position of the following bird 65% of the time on average. Tandem flights vary widely in instantaneous speed (1.0 to 15.6 m s(-1)) and duration (0.72 to 4.71 s), and no single tracking strategy appeared to explain the course taken by the following bird.

  7. Kinematic analysis of tandem gait on a sine wave walkway

    Science.gov (United States)

    Kawakami, Shingo; Fujisawa, Hiroyuki; Tomizawa, Yoshiyuki; Murakami, Kenichi

    2016-01-01

    [Purpose] The purpose of this study was to ascertain the kinematic characteristics on a horizontal plane, including knee joint rotation, when walking with a tandem gait on a sine wave walkway. [Subjects and Methods] Eighteen healthy adults were enrolled as subjects in this study. They walked with a tandem gait on a sine wave walkway. A three-dimensional motion analysis system was used to record data and calculate the trunk, hip joint, and knee joint rotation angles. [Results] The rotation angle ranges for the trunk, hip joint, and knee joint were 23.3°, 53.3°, and 47.3°, respectively. The trunk generally rotated towards the direction of movement, and when turning left using the left leg as the pivot, the hip joint was internally rotated and the knee joint was externally rotated. In contrast, when making a directional change to the right using the left leg as the pivot, the hip joint was externally rotated and the knee joint was internally rotated. [Conclusion] Through tandem gait analysis on a sine wave walkway, knee joint rotation was found to be important in changes of direction. PMID:27799663

  8. Polarized ionic source of the tandem accelerator in Kyoto University

    Energy Technology Data Exchange (ETDEWEB)

    Nakamura, Masanobu; Kuwamoto, Shuichi; Takahashi, Seiji [Kyoto Univ. (Japan). Dept. of Physics] [and others

    1997-02-01

    A polarized ion source developed under the National Laboratory of High Energy Physics was transferred to the tandem accelerator in Kyoto University at beginning of 1993 to constitute a displacement of incidence into the accelerator. This was an atomic beam type polarized ion source, which is designed to adopt permanent magnets for 6 poles magnet to polarize the electron, to take out atomic nucleus on a shape of positive ion by ECR ionizer after transferring its polarization through transition using radio frequency (RFT), to make it negative ion by charge conversion using alkaline metal vapor, and to put it into the tandem accelerator. Test of the positive ion was finished at the National Laboratory of High Energy Physics, and test in Kyoto University was required after its negative ionization. As the estimated cost was unsufficient and entrance into the ion source facility in the tandem accelerator building was limited in Kyoto University, step of development was slow. Here is reported on present state of the ion source which is now operating stably. (G.K.)

  9. Optimal design of high-efficiency tandem cells

    Science.gov (United States)

    Fan, J. C. C.; Tsaur, B.-Y.; Palm, B. J.

    1982-01-01

    Computer analysis indicates that a substantial increase in solar cell conversion efficiencies can be achieved by using two-cell, multi-bandgap tandem structures instead of single-junction cells. Practical AM1 efficiencies of about 30 percent at one sun and over 30 percent at multiple suns are to be expected. The further increases in efficiency calculated for a three-cell tandem structure are much smaller and may not justify the added complexity. For inexpensive two-cell tandem modules, Si is preferred for the bottom cell, and the top-cell material should have a bandgap of 1.75 to 1.80 eV. The GaAs-AlAs and GaAs-GaP systems are very attractive candidates for the top cell. Significant advances have been achieved in growing GaAs on Ge-coated Si substrates (for the two-terminal, two-cell structure) and in growing free-standing ultrathin GaAs layers (for the two-terminal or four-terminal structures). These advances should be transferable to the GaAs-AlAs and GaAs-GaP systems.

  10. Solution processed organic bulk heterojunction tandem solar cells

    Energy Technology Data Exchange (ETDEWEB)

    Albrecht, Steve; Neher, Dieter [Soft Matter Physics, University of Potsdam, D-14476 Potsdam (Germany)

    2011-07-01

    One of the critical issues regarding the preparation of organic tandem solar cells from solution is the central recombination contact. This contact should be highly transparent and conductive to provide high recombination currents. Moreover it should protect the 1st subcell from the solution processing of the 2nd subcell. Here, we present a systematic study of various recombination contacts in organic bulk heterojunction tandem solar cells made from blends of different polymers with PCBM. We compare solution processed recombination contacts fabricated from metal-oxides (TiO{sub 2} and ZnO) and PEDOT:PSS with evaporated recombination contacts made from thin metal layers and molybdenum-oxide. The solar cell characteristics as well as the morphology of the contacts measured by AFM and SEM are illustrated. To compare the electrical properties of the varying contacts we show measurements on single carrier devices for different contact-structures. Alongside we present the results of optical modeling of the subcells and the complete tandem device and relate these results to experimental absorption and reflection spectra of the same structures. Based on these studies, layer thicknesses were adjusted for optimum current matching and device performance.

  11. Two tandem flexible loops in a viscous flow

    Science.gov (United States)

    Ye, Huilin; Wei, Heng; Huang, Haibo; Lu, Xi-yun

    2017-02-01

    Interaction between two tandem flexible loops with tension and bending stiffness in a viscous flow is investigated by numerical simulations. In most cases, the heads of the loops facing the oncoming flow are fixed but flapping around the head is allowed. The effect of the gap distance between the two passive flapping loops (G) on the drag coefficient is investigated in detail. Here, for the first time, the sudden drag force reduction at a specific G, i.e., Gc for the downstream loop has been found in the two tandem flexible loops system. It is different from the drag "jump" behavior in the two tandem rigid cylinder system. Although the drag is partially associated with the flapping amplitude, the drag force reduction of the downstream loop may be mainly attributed to flow regimes transition or vortices merging mode transition. The vortices merging is also analysed from a Lagrangian viewpoint, which gives insight into the mechanism. The effects of Reynolds number (20 ≤ Re ≤100 ) , bending coefficient (10-4≤K ≤2 ×10-2 ) , and tension coefficient (10 ≤S ≤1000 ) are also investigated and the relevant mechanism is explored. If the head of the downstream loop is set free to move laterally, the critical distance (Gc) where the sudden drag reduction occurs would further decrease compared to the fixed case, which is due to the early shedding regime transition.

  12. Thermodynamic limit of bifacial double-junction tandem solar cells

    Science.gov (United States)

    Ryyan Khan, M.; Alam, Muhammad A.

    2015-11-01

    A traditional single-junction solar panel cannot harness ground-scattered light (albedo reflectance, RA ), and also suffers from the fundamental sub-band-gap and the thermalization losses. In this paper, we explain how a "bifacial tandem" panel would dramatically reduce these losses, with corresponding improvement in thermodynamic performance. Our study predicts (i) the optimum combination of the band-gaps, empirically given by Eg(t ) o p t≈Eg(b ) o p t(2 +RA)/3 +(1 -RA) and the (ii) corresponding optimum normalized output power given by ηT(op t ) *≈RA (2 ηSJ (o p t ) ) +(1 -RA ) ηDJ (o p t ) . Empirically, ηT(op t ) * interpolates between the thermodynamic efficiency limit of classical double-junction tandem cell ( ηDJ ) and twice that of a single-junction cell ( ηSJ ). We conclude by explaining how the fundamental loss mechanisms evolve with RA in a bifacial tandem cell.

  13. Solution-processed parallel tandem polymer solar cells using silver nanowires as intermediate electrode.

    Science.gov (United States)

    Guo, Fei; Kubis, Peter; Li, Ning; Przybilla, Thomas; Matt, Gebhard; Stubhan, Tobias; Ameri, Tayebeh; Butz, Benjamin; Spiecker, Erdmann; Forberich, Karen; Brabec, Christoph J

    2014-12-23

    Tandem architecture is the most relevant concept to overcome the efficiency limit of single-junction photovoltaic solar cells. Series-connected tandem polymer solar cells (PSCs) have advanced rapidly during the past decade. In contrast, the development of parallel-connected tandem cells is lagging far behind due to the big challenge in establishing an efficient interlayer with high transparency and high in-plane conductivity. Here, we report all-solution fabrication of parallel tandem PSCs using silver nanowires as intermediate charge collecting electrode. Through a rational interface design, a robust interlayer is established, enabling the efficient extraction and transport of electrons from subcells. The resulting parallel tandem cells exhibit high fill factors of ∼60% and enhanced current densities which are identical to the sum of the current densities of the subcells. These results suggest that solution-processed parallel tandem configuration provides an alternative avenue toward high performance photovoltaic devices.

  14. Establishment of a tandem ionization chamber system in standard mammography beams

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Jonas O. da; Caldas, L.V.E., E-mail: jonas.silva@ipen.b, E-mail: lcaldas@ipen.b [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2011-07-01

    A double-faced tandem ionization chamber system was developed at the Calibration Laboratory of IPEN. It has different collecting electrode materials: aluminium and graphite. The response repeatability and reproducibility and the energy dependence test of this tandem ionization chamber were evaluated. The chamber response stability is within the {+-}3% limit recommended in international standards. The energy dependence test of the ionization chamber system using the tandem curve obtained, presented agreement with literature results. (author)

  15. Os instrumentos de regulação baseados no conhecimento: o caso do programme for international student assessment (PISA Knowledge-based regulation tools (KRT: the programme for international student assessment (PISA case

    Directory of Open Access Journals (Sweden)

    Estela Costa

    2009-12-01

    Full Text Available Este artigo inscreve-se na temática dos novos modos de regulação da educação, em particular nos instrumentos de políticas públicas. No quadro da instrumentação da acção pública, a atenção recai nos instrumentos de regulação baseados no conhecimento (Knowledge-based Regulation Tools [KRT]. Na verdade, a economia mundial fundamenta-se, cada vez mais, no conhecimento, o qual emerge como instrumento de política, regulando os actores sociais e legitimando a decisão política. O Programme for International Student Assessment (PISA, da Organização para Cooperação e Desenvolvimento Económico (OCDE, foi o instrumento escolhido como passível de configurar um KRT. O texto baseiase em seis estudos de caso, assentes em entrevistas e análise documental. Intentando na circulação e no uso do PISA, na Bélgica, Escócia, França, Hungria, Portugal e Roménia, procuramos demonstrar que o PISA se afirma como um KRT, provando a relação circular entre conhecimento e política, dado que, como instrumento de política, produz conhecimento e, como instrumento científico, produz política.This text focuses on the study of a KRT (Knowledgebased Regulation Tool, within the wider framework of the new modes of regulation in education, and use of instruments in public action. The world economy is gradually more knowledge-based. Knowledge emerges as a tool for policy-making and for regulating social actors, and legitimating the political decision-making. We choose the OECD's Program for International Student Assessment (PISA as an example of a KRT. The article is based on six case-studies, with interviews and document analysis. Our goal was to study the circulation and use of PISA, in Belgium, Scotland, France, Hungary, Portugal and Romania, trying to show that PISA is indeed a KRT, thus proving the circular relationship between knowledge and policy, because as a policy instrument it produces knowledge, and as a scientific tool it produces policy.

  16. Método para definição de layout em sistemas job-shop baseado em dados históricos Historical data-based job-shop layout systems definition method

    Directory of Open Access Journals (Sweden)

    Maurício Tomelin

    2010-01-01

    Full Text Available O presente trabalho propõe um método para a solução do problema de definição de layout tipo job-shop baseado em dados históricos de produção, recursos disponíveis e características de produção. Os parâmetros utilizados foram a quantidade total e a frequência de vendas, a lucratividade, o tempo total de processamento e o tempo de espera de cada produto, gerando assim a classificação dos produtos. Os roteiros de produção foram comparados e, em função dos parâmetros, foi determinado o grau de importância de cada ligação entre os recursos. As ligações foram submetidas a um modelo matemático para a determinação da posição de cada recurso no layout. O método desenvolvido foi aplicado a uma empresa de usinagem com característica de job-shop. Os dados submetidos ao método permitiram uma sugestão de layout que tem como objetivo minimizar a distância dos recursos de processamento.This paper proposes a method for solving the job-shop layout problem definition, based on historical production data, available resources and production characteristics. The products were classified according to total sales, sales frequency, profitability, total processing time and stand-by time. The production path was compared and the degree of importance of each link between resources was determined. Path comparisons were made to quantify the same routes and the route differences, generating similar routes. The links were submitted to a mathematical model to determine the position of resources in the layout. The method developed was applied to a machining company with a job-shop profile. When the company's data was subjected to the method, it enabled the development of a layout, the main goal of which was to minimize distances between product-processing resources.

  17. Índices baseados no número de clientes para localização de itens em armazéns Indexes based on the number of customers to locate items in warehouse

    Directory of Open Access Journals (Sweden)

    Marcele Elisa Fontana

    2013-01-01

    Full Text Available Para se obter eficiência nas operações de armazenagem, um fator importante é estabelecer a política ótima de atribuição da localização dos itens em armazéns. Para tanto, um dos índices mais difundidos e utilizados é o cuber-per-order (COI. No entanto, observa-se que há situações em que o uso do COI pode concentrar vantagens para uma minoria de clientes. Nesse sentido, este artigo propõe verificar as consequências da utilização de índices alternativos (COIC e CIC, baseados no número de clientes que demandam cada tipo de produto (item, sobre o desempenho de um armazém em relação à utilização do COI. Conclui-se que considerar o número de clientes na determinação da política ótima de atribuição de locais aos itens armazenados proporciona uma maior vantagem competitiva, uma vez que um número maior de clientes pode ser beneficiado. Isso representa uma oportunidade de elevar o nível de serviço oferecido pelo armazém aos clientes.An important factor to obtain efficiency of storage operations is to establish an optimal policy for storage location assignment. To this end, one of the indexes more circulated and used is the Cuber-per-Order (COI. However, it is observed that there are situations where the use of COI can concentrate advantages to a minority of clients. In this sense, this paper proposes to verify the effects on the performance of a warehouse when using alternative indexes (COIC and CIC, based on the number of clients that require each type of product (item, compared to the COI. It was possible to conclude that when the number of clients is considered to determine optimal policy for storage location assignment, the warehouse can acquire a competitive advantage, since the largest number of clients can be benefited. This represents an opportunity to raise the service level offered by the warehouse to its clients.

  18. The application of tandem mass spectrometry to neonatal screening for inherited disorders of intermediary metabolism.

    Science.gov (United States)

    Chace, Donald H; Kalas, Theodore A; Naylor, Edwin W

    2002-01-01

    This review is intended to serve as a practical guide for geneticists to current applications of tandem mass spectrometry to newborn screening. By making dried-blood spot analysis more sensitive, specific, reliable, and inclusive, tandem mass spectrometry has improved the newborn detection of inborn errors of metabolism. Its innate ability to detect and quantify multiple analytes from one prepared blood specimen in a single analysis permits broad recognition of amino acid, fatty acid, and organic acid disorders. An increasing number of newborn screening programs are either utilizing or conducting pilot studies with tandem mass spectrometry. It is therefore imperative that the genetics community be familiar with tandem mass spectrometric newborn screening.

  19. Life cycle analysis of organic tandem solar cells: When are they warranted?

    DEFF Research Database (Denmark)

    Espinosa Martinez, Nieves; Krebs, Frederik C

    2014-01-01

    . As an initial investigation into the potential viability of the tandem or multi-junction approach we have engaged in a detailed analysis based on the manufacturing energy for each step within the tandem module supply chain for full ambient processing of thin flexible polymer tandem solar cells prepared entirely...... by roll processing methods. We present a comprehensive overview of relevant research results on how the energy consumption affects the energy balance when using single and multi-junction solar cells. Based on the above question we calculate the minimum efficiency that the tandem or multi-junction should...

  20. Improved Tandem Measurement Techniques for Aerosol Particle Analysis

    Science.gov (United States)

    Rawat, Vivek Kumar

    Non-spherical, chemically inhomogeneous (complex) nanoparticles are encountered in a number of natural and engineered environments, including combustion systems (which produces highly non-spherical aggregates), reactors used in gas-phase materials synthesis of doped or multicomponent materials, and in ambient air. These nanoparticles are often highly diverse in size, composition and shape, and hence require determination of property distribution functions for accurate characterization. This thesis focuses on development of tandem mobility-mass measurement techniques coupled with appropriate data inversion routines to facilitate measurement of two dimensional size-mass distribution functions while correcting for the non-idealities of the instruments. Chapter 1 provides the detailed background and motivation for the studies performed in this thesis. In chapter 2, the development of an inversion routine is described which is employed to determine two dimensional size-mass distribution functions from Differential Mobility Analyzer-Aerosol Particle Mass analyzer tandem measurements. Chapter 3 demonstrates the application of the two dimensional distribution function to compute cumulative mass distribution function and also evaluates the validity of this technique by comparing the calculated total mass concentrations to measured values for a variety of aerosols. In Chapter 4, this tandem measurement technique with the inversion routine is employed to analyze colloidal suspensions. Chapter 5 focuses on application of a transverse modulation ion mobility spectrometer coupled with a mass spectrometer to study the effect of vapor dopants on the mobility shifts of sub 2 nm peptide ion clusters. These mobility shifts are then compared to models based on vapor uptake theories. Finally, in Chapter 6, a conclusion of all the studies performed in this thesis is provided and future avenues of research are discussed.

  1. Caracterização de perfis de consumidores quanto à disposição de adoção de produtos e serviços baseados em tecnologia a partir da utilização do método de Grade of Membership (GOM)

    OpenAIRE

    Pereira, Danielle Ramos de Miranda; Pinto,Marcelo de Rezende; Santos,Leonardo Lemos da Silveira

    2007-01-01

    Diante do constante avanço das tecnologias atuais, bem como da notável emergência de novas tecnologias, um dos desafios fundamentais para as empresas que pretendem desenvolver produtos e serviços baseados em tecnologia é assegurar a adoção e a satisfação por parte dos consumidores. À despeito de sua importância, percebe-se que existem ainda poucas investigações que contemplam essa temática no contexto brasileiro. Sendo assim, este trabalho procurou investigar o quão prontos os consumido...

  2. Recuperação inteligente de jurisprudência: uma avaliação do raciocínio baseado em casos aplicado a recuperação de jurisprudências no Tribunal Regional Eleitoral do Distrito Federal

    Directory of Open Access Journals (Sweden)

    Symball Rufino de Oliveira

    2011-04-01

    Full Text Available Trata-se de uma pesquisa cujo objeto é avaliar a medida de precisão de um sistema de recuperação de informação jurídica (jurisprudência que utiliza técnica de inteligência artificial conhecida como Raciocínio Baseado em Casos (RBC. Nesse modelo as jurisprudências são organizadas sob a forma de casos jurídicos concretos. O raciocínio baseado em casos tem como princípio a idéias de que um caso jurídico passado pode ser útil para resolver um problema atual, desde que exista entre eles algum grau de semelhança. Para estabelecer semelhanças entre casos atuais e passados o modelo estudado propõe o uso de cálculo de similaridade que é realizado com base na comparação de índices temáticos obtidos a partir do processo de indexação realizado por especialistas utilizando-se como apoio um tesauro jurídico. Esta pesquisa utiliza como universo as jurisprudências produzidas pelo Tribunal Regional Eleitoral do Distrito Federal. A amostra foi composta, considerando o recorte dado à pesquisa, por jurisprudências eleitorais produzidas nas eleições gerais de 2006 no Distrito Federal. Para realizar a avaliação do modelo, foi construído um protótipo do sistema de recuperação de informação baseado em casos. Em seguida, avaliou-se o protótipo quanto ao grau de precisão obtido no resultado de um conjunto de buscas. O método adotado para as avaliações foi o mesmo utilizado na Text REtrieval Conference (TREC de 2007, tarefa Legal Track. Após a coleta dos dados foi elaborado um relatório discutindo a possibilidade do sistema de recuperação de informação baseado em casos ser considerado um paradigma para a recuperação de informação jurídica eleitoral.

  3. Modelo de enfermagem baseado nas atividades de vida diária: adolescente diabética e deficiente visual Modelo de enfermería fundamentado en las actividades de la vida cotidiana: adolescente con diabetes y deficiencia visual Nursing model based on activities of daily living: a diabetic and visually-impaired adolescent

    OpenAIRE

    Camilla Pontes Bezerra; Lorita Marlena Freitag Pagliuca; Marli Teresinha Gimeniz Galvão

    2009-01-01

    O diabetes mellitus, doença crônico-degenerativa, pode comprometer a retina. Objetivou-se analisar a eficácia do cuidado de enfermagem fundamentado no Modelo de Enfermagem Baseado nas Atividades da Vida Diária a uma adolescente com deficiência visual decorrente do diabetes mellitus tipo I, utilizando o estudo de caso. Os dados foram coletados em setembro 2006 por entrevistas no domicílio. Os resultados mostram ambiente doméstico inseguro devido a iluminação inadequada, nutrição alterada e déf...

  4. Comparação dos tempos de geração e digitação de laudos radiológicos entre um sistema eletrônico baseado em voz sobre IP (VoIP e um sistema tradicional baseado em papel Comparison between the time required to generate and type radiology reports by means of VoIP-based system and a traditional paper-based system

    Directory of Open Access Journals (Sweden)

    Dácio Miranda Ferreira

    2010-02-01

    Full Text Available OBJETIVO: Comparar os tempos de geração e digitação de laudos radiológicos entre um sistema eletrônico baseado na tecnologia de voz sobre o protocolo de internet (VoIP e o sistema tradicional, em que o radiologista escreve o laudo à mão. MATERIAIS E MÉTODOS: Foi necessário modelar, construir e implantar o sistema eletrônico proposto, capaz de gravar o laudo em formato de áudio digital, e compará-lo com o tradicional já existente. Por meio de formulários, radiologistas e digitadores anotaram os tempos de geração e digitação dos laudos nos dois sistemas. RESULTADOS: Comparadas as médias dos tempos entre os sistemas, o eletrônico apresentou redução de 20% (p = 0,0410 do tempo médio de geração do laudo em comparação com o sistema tradicional. O tradicional foi mais eficiente em relação ao tempo de digitação, uma vez que a média de tempo do eletrônico foi três vezes maior (p OBJECTIVE: To compare the time required for generation and typing of radiology reports by means of an electronic system based on the technology of voice over internet protocol (VoIP and the traditional system, in which the report is handwritten by the radiologist. MATERIALS AND METHODS: It was necessary to model, build and deploy the proposed electronic system, capable of recording the reports in a digital audio format and comparing it with the traditional method. Radiologists and transcriptionists recorded the reports generation and typing times for both systems, using appropriate forms. RESULTS: When the mean times between both systems were compared, those from the electronic system presented a reduction of 20% (p = 0.0410 in the report generation time as compared with the traditional method. On the other hand, the traditional method was more efficient with respect to typing time, as the mean typing time with the electronic system was three times longer (p < 0.0001. CONCLUSION: The results demonstrated a statistically significant difference

  5. Tandem synthesis of alternating polyesters from renewable resources.

    Science.gov (United States)

    Robert, Carine; de Montigny, Frédéric; Thomas, Christophe M

    2011-12-13

    The vast majority of commodity materials are obtained from petrochemical feedstocks. These resources will plausibly be depleted within the next 100 years, and the peak in global oil production is estimated to occur within the next few decades. In this regard, biomass represents an abundant carbon-neutral renewable resource for the production of polymers. Here we report a new strategy, based on tandem catalysis, to obtain renewable materials. Commercially available complexes are found to be efficient catalysts for alternating polyesters from the cyclization of dicarboxylic acids followed by alternating copolymerization of the resulting anhydrides with epoxides. This operationally simple method is an attractive strategy for the production of new biodegradable polyesters.

  6. Tandem isomerization/telomerization of long chain dienes

    Directory of Open Access Journals (Sweden)

    Laura eTorrente Murciano

    2014-06-01

    Full Text Available The first example of a tandem reaction involving double-bond migration in combination with telomerization is reported. Homogeneous and heterogeneous Ru catalysts were employed as isomerisation catalysts, and telomerization was realized using a homogeneous Pd(0 precursor complex with a N-heterocyclic carbene (IMes ligand. Overall conversions approaching 60 % were achieved with the best selectivity to telomerization products of 91% attained at 11 % conversion. Conversion was markedly higher in the presence of longer-chain alcohol (1-butanol as the nucleophile (telogen.

  7. Finding all sorting tandem duplication random loss operations

    DEFF Research Database (Denmark)

    Bernt, Matthias; Chen, Kuan Yu; Chen, Ming Chiang

    2011-01-01

    A tandem duplication random loss (TDRL) operation duplicates a contiguous segment of genes, followed by the random loss of one copy of each of the duplicated genes. Although the importance of this operation is founded by several recent biological studies, it has been investigated only rarely from...... a theoretical point of view. Of particular interest are sorting TDRLs which are TDRLs that, when applied to a permutation representing a genome, reduce the distance towards another given permutation. The identification of sorting genome rearrangement operations in general is a key ingredient of many algorithms...

  8. Tandem mass spectrometry data quality assessment by self-convolution

    Directory of Open Access Journals (Sweden)

    Tham Wai

    2007-09-01

    Full Text Available Abstract Background Many algorithms have been developed for deciphering the tandem mass spectrometry (MS data sets. They can be essentially clustered into two classes. The first performs searches on theoretical mass spectrum database, while the second based itself on de novo sequencing from raw mass spectrometry data. It was noted that the quality of mass spectra affects significantly the protein identification processes in both instances. This prompted the authors to explore ways to measure the quality of MS data sets before subjecting them to the protein identification algorithms, thus allowing for more meaningful searches and increased confidence level of proteins identified. Results The proposed method measures the qualities of MS data sets based on the symmetric property of b- and y-ion peaks present in a MS spectrum. Self-convolution on MS data and its time-reversal copy was employed. Due to the symmetric nature of b-ions and y-ions peaks, the self-convolution result of a good spectrum would produce a highest mid point intensity peak. To reduce processing time, self-convolution was achieved using Fast Fourier Transform and its inverse transform, followed by the removal of the "DC" (Direct Current component and the normalisation of the data set. The quality score was defined as the ratio of the intensity at the mid point to the remaining peaks of the convolution result. The method was validated using both theoretical mass spectra, with various permutations, and several real MS data sets. The results were encouraging, revealing a high percentage of positive prediction rates for spectra with good quality scores. Conclusion We have demonstrated in this work a method for determining the quality of tandem MS data set. By pre-determining the quality of tandem MS data before subjecting them to protein identification algorithms, spurious protein predictions due to poor tandem MS data are avoided, giving scientists greater confidence in the

  9. Parametric design study of tandem mirror fusion reactors

    Energy Technology Data Exchange (ETDEWEB)

    Carlson, G.A.

    1977-05-27

    The parametric design study of the tandem mirror reactor (TMR) is described. The results of this study illustrate the variation of reactor characteristics with changes in the independent design parameters, reveal the set of design parameters which minimizes the cost of the reactor, and show the sensitivity of the optimized design to physics and technological uncertainties. The total direct capital cost of an optimized 1000 MWe TMR is estimated to be $1300/kWe. The direct capital cost of a 2000 MWe plant is less than $1000/kWe.

  10. A numerical parametric study on hydrofoil interaction in tandem

    Science.gov (United States)

    Kemal, Omer

    2015-01-01

    Understanding the effects of the parameters affecting the interaction of tandem hydrofoil system is a crucial subject in order to fully comprehend the aero/hydrodynamics of any vehicle moving inside a fluid. This study covers a parametric study on tandem hydrofoil interaction in both potential and viscous fluids using iterative Boundary Element Method (BEM) and RANSE. BEM allows a quick estimation of the flow around bodies and may be used for practical purposes to assess the interaction inside the fluid. The produced results are verified by conformal mapping and Finite Volume Method (FVM). RANSE is used for viscous flow conditions to assess the effects of viscosity compared to the inviscid solutions proposed by BEM. Six different parameters are investigated and they are the effects of distance, thickness, angle of attack, chord length, aspect ratio and tapered wings. A generalized 2-D code is developed implementing the iterative procedure and is adapted to generate results. Effects of free surface and cavitation are ignored. It is believed that the present work will provide insight into the parametric interference between hydrofoils inside the fluid

  11. A numerical parametric study on hydrofoil interaction in tandem

    Directory of Open Access Journals (Sweden)

    Kemal Omer

    2015-01-01

    Full Text Available Understanding the effects of the parameters affecting the interaction of tandem hydrofoil system is a crucial subject in order to fully comprehend the aero/hydrodynamics of any vehicle moving inside a fluid. This study covers a parametric study on tandem hydrofoil interaction in both potential and viscous fluids using iterative Boundary Element Method (BEM and RANSE. BEM allows a quick estimation of the flow around bodies and may be used for practical purposes to assess the interaction inside the fluid. The produced results are verified by conformal mapping and Finite Volume Method (FVM. RANSE is used for viscous flow conditions to assess the effects of viscosity compared to the inviscid solutions proposed by BEM. Six different parameters are investigated and they are the effects of distance, thickness, angle of attack, chord length, aspect ratio and tapered wings. A generalized 2-D code is developed implementing the iterative procedure and is adapted to generate results. Effects of free surface and cavitation are ignored. It is believed that the present work will provide insight into the parametric interference between hydrofoils inside the fluid

  12. A numerical parametric study on hydrofoil interaction in tandem

    Directory of Open Access Journals (Sweden)

    Omer Kemal Kinaci

    2015-01-01

    Full Text Available Understanding the effects of the parameters affecting the interaction of tandem hydrofoil system is a crucial subject in order to fully comprehend the aero/hydrodynamics of any vehicle moving inside a fluid. This study covers a parametric study on tandem hydrofoil interaction in both potential and viscous fluids using iterative Boundary Element Method (BEM and RANSE. BEM allows a quick estimation of the flow around bodies and may be used for practical purposes to assess the interaction inside the fluid. The produced results are verified by conformal mapping and Finite Volume Method (FVM. RANSE is used for viscous flow conditions to assess the effects of viscosity compared to the inviscid solutions proposed by BEM. Six different parameters are investigated and they are the effects of distance, thickness, angle of attack, chord length, aspect ratio and tapered wings. A generalized 2-D code is developed implementing the iterative procedure and is adapted to generate results. Effects of free surface and cavitation are ignored. It is believed that the present work will provide insight into the parametric interference between hydrofoils inside the fluid.

  13. Tandem photovoltaic cells with a composite intermediate layer

    Energy Technology Data Exchange (ETDEWEB)

    Travkin, V. V., E-mail: trav@ipmras.ru; Pakhomov, G. L.; Luk’anov, A. Yu. [Russian Academy of Sciences, Institute for Physics of Microstructures (Russian Federation); Stuzhin, P. A. [Ivanovo State University of Chemistry and Technology (Russian Federation)

    2015-11-15

    We have fabricated and tested tandem photovoltaic cells containing series-connected subcells of the “oxide–organic semiconductor–metal” type. The organic semiconductors were two phthalocyanine dyes (SubPc and PcVO); Al or Ag:Mg were used as capping metallic electrodes. A semitransparent composite metal–oxide layer formed by molybdenum oxide MoO{sub x} deposited over an ultrathin Al layer is used to join the subcells. Additionally, a MoO{sub x} layer deposited onto glass/ITO substrates serves as an anode buffer in the front subcell, and LiF deposited onto the dye layers serves as a cathode buffer in the front or rear subcells. Upon optimization of the thickness and composition of the intermediate layer, the open circuit voltage U{sub oc} amounts to 1.6 V reflecting total summation of the contributions from the each of the subcells at a wide spectral coating from 300–1000 nm. The fill factor in the tandem cell is not worse than in individually made single cells with the same scheme or in disconnected subcells.

  14. Expression Divergence of Tandemly Arrayed Genes in Human and Mouse

    Directory of Open Access Journals (Sweden)

    Valia Shoja

    2007-01-01

    Full Text Available Tandemly arrayed genes (TAGs account for about one third of the duplicated genes in eukaryotic genomes, yet there has not been any systematic study of their gene expression patterns. Taking advantage of recently published large-scale microarray data sets, we studied the expression divergence of 361 two-member TAGs in human and 212 two-member TAGs in mouse and examined the effect of sequence divergence, gene orientation, and chromosomal proximity on the divergence of TAG expression patterns. Our results show that there is a weak negative correlation between sequence divergence of TAG members and their expression similarity. There is also a weak negative correlation between chromosomal proximity of TAG members and their expression similarity. We did not detect any significant relationship between gene orientation and expression similarity. We also found that downstream TAG members do not show significantly narrower expression breadth than upstream members, contrary to what we predict based on TAG expression divergence hypothesis that we propose. Finally, we show that both chromosomal proximity and expression correlation in TAGs do not differ significantly from their neighboring non-TAG gene pairs, suggesting that tandem duplication is unlikely to be the cause for the higher-than-random expression association between neighboring genes on a chromosome in human and mouse.

  15. An unprecedented, tandem Aldol-Grob reaction sequence

    Energy Technology Data Exchange (ETDEWEB)

    Kabalka, G.W.; Tejedor, D.; Li, N.S.; Malladi, R.R.; Trotman, S. [Univ. of Tennessee, Knoxville, TN (United States)

    1998-09-18

    The authors report an unprecedented, tandem Aldol-Grob sequence involving the reaction of ketones with aromatic aldehydes in nonnucleophilic solvents in the presence of boron trifluoride. Although a detailed study of the reaction mechanism has not yet been completed, the consistent formation of (E)-alkene products, as well as the fact that aromatic aldehydes appear to be required, would point toward the intermediacy of a carbocation derivative. A reasonable mechanism would involve the formation of the mixed aldol followed by the formation and subsequent nonsynchronous ring opening of a lactol. The proposed fragmentation is reminiscent of two-step Grob fragmentations that have been reported for N-halo-{alpha}-amino acids and cyclobutane hemiacetals as well as the acid-catalyzed fragmentation of {beta}-hydroxy acetals. The authors examined the effect of various acids on the reaction sequence in order to ascertain which would be most efficient. They conclude that boron trifluoride is the most effective of the acids studied in achieving the new tandem condensation-cleavage sequence.

  16. Development of high current injector for tandem accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Baba, Takashi; Iwamoto, Eiji [Nissin - High Voltage Co. Ltd., Kyoto (Japan); Kishimoto, Naoki; Saito, Tetsuya; Mori, Yoshiharu

    1997-02-01

    The development of the electrostatic type tandem accelerators has been carried out so far, but by the recent remarkable progress of negative ion sources, the beam current which was inconceivable so far has become obtainable, and the use as the electrostatic type tandem accelerators is expanding rapidly. The problem which must be solved in the development of a high energy, large current heavy ion injection device is the development of an injector. As to the generation of negative ions, by the development of plasma sputter negative ion sources, the almost satisfactory performance has been obtained in beam current, emittance, life and so on, but as for the transport and control of generated negative ion beam, there is the large problem of spatial charge effect. This time, the verifying test on this problem was carried out, therefore, its contents and results are reported. The equipment which was developed this time was delivered to the Institute for Materials Research. Its specifications are shown. The whole constitution, negative ion source, and beam transport system are described. Beam generation test and spatial charge effect test are reported. The test stand was made, and in the verifying test, the maximum beams of 4 mA in Cu and 3 mA in Ni were able to be generated and transported. The effect of the countermeasures to spatial charge effect was confirmed. (K.I.)

  17. Sulphur hexafluoride as a stripper gas for tandem accelerators

    Energy Technology Data Exchange (ETDEWEB)

    Hotchkis, M.A.C., E-mail: mah@ansto.gov.au; Child, D.; Fink, D.; Garton, D.; Levchenko, V.; Wilcken, K.

    2013-05-01

    Highlights: •Sulphur hexafluoride is investigated as a stripper gas in tandem accelerators. •For heavy ions at low terminal voltage, mean charge states are found to be up to 1 charge unit higher than with argon gas. •Charge state distributions are found to be broader than with argon gas. •For charge states above the mean charge state, yields are typically doubled using SF{sub 6}. •Using SF{sub 6} stripper gas, the efficiency of actinides AMS analysis is doubled. -- Abstract: We have investigated sulphur hexafluoride as a stripper gas in tandem accelerators by using the ANTARES accelerator system at ANSTO to measure charge state distributions for this gas. Results are reported at 4 MV terminal voltage for injected negative ions ranging from carbon to uranium oxide. For iodine and thorium the distributions are extended across a range of energies of practical use for accelerator mass spectrometry, ion beam analysis and other accelerator applications. Charge state distributions using sulphur hexafluoride are found to have mean charge states up to 1 charge unit higher than, and to be broader than, corresponding distributions for argon gas, except in the case of carbon beams. As a result, SF{sub 6} is shown to provide significantly higher yields for charge states of heavy ions above the mean charge state. We now perform actinide AMS measurements with 9% yield to the 5+ charge state, compared to 4–5% achieved previously with argon gas.

  18. Cloud parallel processing of tandem mass spectrometry based proteomics data.

    Science.gov (United States)

    Mohammed, Yassene; Mostovenko, Ekaterina; Henneman, Alex A; Marissen, Rob J; Deelder, André M; Palmblad, Magnus

    2012-10-05

    Data analysis in mass spectrometry based proteomics struggles to keep pace with the advances in instrumentation and the increasing rate of data acquisition. Analyzing this data involves multiple steps requiring diverse software, using different algorithms and data formats. Speed and performance of the mass spectral search engines are continuously improving, although not necessarily as needed to face the challenges of acquired big data. Improving and parallelizing the search algorithms is one possibility; data decomposition presents another, simpler strategy for introducing parallelism. We describe a general method for parallelizing identification of tandem mass spectra using data decomposition that keeps the search engine intact and wraps the parallelization around it. We introduce two algorithms for decomposing mzXML files and recomposing resulting pepXML files. This makes the approach applicable to different search engines, including those relying on sequence databases and those searching spectral libraries. We use cloud computing to deliver the computational power and scientific workflow engines to interface and automate the different processing steps. We show how to leverage these technologies to achieve faster data analysis in proteomics and present three scientific workflows for parallel database as well as spectral library search using our data decomposition programs, X!Tandem and SpectraST.

  19. Aerodynamics of two-dimensional flapping wings in tandem configuration

    Science.gov (United States)

    Lua, K. B.; Lu, H.; Zhang, X. H.; Lim, T. T.; Yeo, K. S.

    2016-12-01

    This paper reports a fundamental investigation on the aerodynamics of two-dimensional flapping wings in tandem configuration in forward flight. Of particular interest are the effects of phase angle (φ) and center-to-center distance (L) between the front wing and the rear wing on the aerodynamic force generation at a Reynolds number of 5000. Both experimental and numerical methods were employed. A force sensor was used to measure the time-history aerodynamic forces experienced by the two wings and digital particle image velocimetry was utilized to obtain the corresponding flow structures. Both the front wing and the rear wing executed the same simple harmonic motions with φ ranging from -180° to 180° and four values of L, i.e., 1.5c, 2c, 3c, and 4c (c is the wing chord length). Results show that at fixed L = 2c, tandem wings perform better than the sum of two single wings that flap independently in terms of thrust for phase angle approximately from -90° to 90°. The maximum thrust on the rear wing occurs during in-phase flapping (φ = 0°). Correlation of transient thrust and flow structure indicates that there are generally two types of wing-wake interactions, depending on whether the rear wing crosses the shear layer shed from the front wing. Finally, increasing wing spacing has similar effect as reducing the phase angle, and an approximate mathematical model is derived to describe the relationship between these two parameters.

  20. Numerical simulation of bionic foils in tandem arrangement

    Directory of Open Access Journals (Sweden)

    Kai Zhou

    2016-05-01

    Full Text Available Based on the backgrounds of underwater propulsors with high hydrodynamic performance, the article focuses on the flapping foils in tandem arrangement and tries to formulate the physical mode and mathematical model of flapping propulsion. Using the commercial software Fluent, the governing equations are discretized by the finite volume method, and dynamic mesh method is adopted to solve the moving boundaries. In order to verify validity and feasibility of the method, hydrodynamic performance of single flapping foil is analyzed. The present results of single flapping foil compare well with those in experimental researches. After that, numerical simulations of flapping foils in tandem arrangement are conducted to reveal the energy absorption mechanisms. By extracting performance parameters and characteristics of the flow field, the interaction between upstream foil and downstream foil is analyzed. The results indicate that the vortices shedding from upstream foil have a significant effect on the hydrodynamic performance of downstream foil, and the downstream foil can use energy from the flow field to improve the hydrodynamic performance. Therefore, the hydrodynamic performance of the system can be improved by adjusting the locations of foils and motion parameters.

  1. Development of a tiny tandem balloon system for atmospheric observation

    Science.gov (United States)

    Saito, Yoshitaka; Yamada, Kazuhiko; Fujiwara, Masatomo

    2016-07-01

    A tandem balloon system with a combination of a zero-pressure balloon on top and a super-pressure balloon on the bottom has a unique trajectory characteristic, with different flight altitudes between day and night and thus with ascending and descending motions at dawn and dusk, respectively. This characteristic provides a unique opportunity to explore the atmosphere, e.g., the upper tropospheric and lower stratospheric region with cross-tropopause measurements twice a day. We started development of a tiny tandem balloon system using a 10 m^{3} super-pressure balloon and a 100 m^{3} zero-pressure balloon, with a capability of carrying 3 kg of payload. One of the scientific targets is to measure water vapor, cloud particles, and temperature around the tropical tropopause which is the entry point of the stratospheric and mesospheric meridional circulation. For the data transfer, the iridium satellite communication module, SBD9603 is used. In this paper, the current status of the development will be reported.

  2. Pedagogical considerations for a web-based tandem language learning environment

    NARCIS (Netherlands)

    Appel, C; Mullen, T

    2000-01-01

    Tandem language learning strategies have long been recognised for their pedagogical value. E-mail tandem exchanges have allowed learners to engage in active communicative contact with native speakers of their target language, but research around these exchanges has suffered due to difficulties with

  3. Synthesis of Functionalized Enynes by Zinc Promoted Tandem Fragmentation-Propargylation of 5-Iodofuranosides

    DEFF Research Database (Denmark)

    Poulsen, Carina Storm; Madsen, Robert

    1999-01-01

    In the presence of zinc and propargyl bromide methyl 5-iodofuranosides undergo a tandem fragmentation propargylation to produce functionalized enynes......In the presence of zinc and propargyl bromide methyl 5-iodofuranosides undergo a tandem fragmentation propargylation to produce functionalized enynes...

  4. Solution-processed organic tandem solar cells with embedded optical spacers

    NARCIS (Netherlands)

    Hadipour, Afshin; de Boer, Bert; Blom, Paul W. M.

    2007-01-01

    We demonstrate a solution-processed polymer tandem solar cell in which the two photoactive single cells are separated by an optical spacer. The use of an optical spacer allows for an independent optimization of both the electronic and optical properties of the tandem cell. The optical transmission

  5. Authentication of Fish Products by Large-Scale Comparison of Tandem Mass Spectra

    DEFF Research Database (Denmark)

    Wulff, Tune; Nielsen, Michael Engelbrecht; Deelder, André M.

    2013-01-01

    a new robust, proteome-wide tandem mass spectrometry method for species recognition and food product authentication. The method does not use or require any genome sequences or selection of tandem mass spectra but uses all acquired data. The experimental steps were performed in a simple, standardized...

  6. Simulation of Two Dimensional Electrophoresis and Tandem Mass Spectrometry for Teaching Proteomics

    Science.gov (United States)

    Fisher, Amanda; Sekera, Emily; Payne, Jill; Craig, Paul

    2012-01-01

    In proteomics, complex mixtures of proteins are separated (usually by chromatography or electrophoresis) and identified by mass spectrometry. We have created 2DE Tandem MS, a computer program designed for use in the biochemistry, proteomics, or bioinformatics classroom. It contains two simulations--2D electrophoresis and tandem mass spectrometry.…

  7. Simulation of Two Dimensional Electrophoresis and Tandem Mass Spectrometry for Teaching Proteomics

    Science.gov (United States)

    Fisher, Amanda; Sekera, Emily; Payne, Jill; Craig, Paul

    2012-01-01

    In proteomics, complex mixtures of proteins are separated (usually by chromatography or electrophoresis) and identified by mass spectrometry. We have created 2DE Tandem MS, a computer program designed for use in the biochemistry, proteomics, or bioinformatics classroom. It contains two simulations--2D electrophoresis and tandem mass spectrometry.…

  8. Numerical Investigation & Comparison of a Tandem-Bladed Turbocharger Centrifugal Compressor Stage with Conventional Design

    Institute of Scientific and Technical Information of China (English)

    Syed Noman Danish; Shafiq Rehman Qureshi; Abdelrahman EL-Leathy; Salah Ud-Din Khan; Usama Umer; Ma Chaochen

    2014-01-01

    Extensive numerical investigations of the performance and flow structure in an unshrouded tandem-bladed centrifugal compressor are presented in comparison to a conventional compressor.Stage characteristics are explored for various tip clearance levels,axial spacings and circumferential clockings.Conventional impeller was modified to tandem-bladed design with no modifications in backsweep angle,meridional gas passage and camber distributions in order to have a true comparison with conventional design.Performance degradation is observed for both the conventional and tandem designs with increase in tip clearance.Linear-equation models for correlating stage characteristics with tip clearance are proposed.Comparing two designs,it is clearly evident that the conventional design shows better performance at moderate flow rates.However; near choke flow,tandem design gives better results primarily because of the increase in throat area.Surge point flow rate also seems to drop for tandem compressor resulting in increased range of operation.

  9. Characterization of recruitment through tandem running in an Indian queenless ant Diacamma indicum

    Science.gov (United States)

    Kaur, Rajbir; Joseph, Joby; Anoop, Karunakaran

    2017-01-01

    Tandem running is a primitive recruitment method employed by many ant genera. This study characterizes this behaviour during the recruitment of colony mates to a new nest in an Indian ant Diacamma indicum. Tandem leaders who have knowledge of the new nest lead a single follower at a time, to the destination by maintaining physical contact. In order to characterize tandem running, we captured and analysed 621 invitations, 217 paths and 226 termination events. Remarkably, not a single colony member was lost. While invitations were stereotypic in behaviour, termination was not. Analysis of speed revealed that the average transport speed was 4.2 cm s−1. Coupled adult-brood transport was slower than other transports but was more efficient than individual trips. Comparing tandem running with other popular recruitment methods in ants allows us to postulate that even though tandem running is primitive it is probably just another means to achieve the same end.

  10. Bifacial Si Heterojunction-Perovskite Organic-Inorganic Tandem to Produce Highly Efficient Solar Cell

    CERN Document Server

    Asadpour, Reza; Khan, M Ryyan; Alam, Muhammad A

    2015-01-01

    As single junction thin-film technologies, both Si heterojunction (HIT) and Perovskite based solar cells promise high efficiencies at low cost. One expects that a tandem cell design with these cells connected in series will improve the efficiency further. Using a self-consistent numerical modeling of optical and transport characteristics, however, we find that a traditional series connected tandem design suffers from low Jsc due to band-gap mismatch and current matching constraints. It requires careful thickness optimization of Perovskite to achieve any noticeable efficiency gain. Specifically, a traditional tandem cell with state-of-the-art HIT (24%) and Perovskite (20%) sub-cells provides only a modest tandem efficiency of ~25%. Instead, we demonstrate that a bifacial HIT/Perovskite tandem design decouples the optoelectronic constraints and provides an innovative path for extraordinary efficiencies. In the bifacial configuration, the same state-of the-art sub-cells achieve a normalized output of 33%, exceed...

  11. Sistema de equações para simulação do crescimento e da produção em povoamentos de Eucalyptus grandis Hill ex Maiden. sem desbaste baseado no modelo de clutter / An equation system to simulate the growth and the yield in stands of unthinned Euclyptus grandis Hill Ex Maiden based on the clutter model

    Directory of Open Access Journals (Sweden)

    César Santana

    2005-08-01

    Full Text Available O objetivo principal deste estudo foi desenvolver um sistema de equações baseado no modelo compatível de crescimento e produção de Clutter para projeção do volume futuro em povoamentos de Eucalyptus grandis Hill ex Maiden. conduzidos sob regime ‘pulpwood’. Para tal fim foram utilizados dados provenientes de cento e quarenta e quatro parcelas permanentes do inventário florestal contínuo da empresa, considerando os anos de 1996 a 2002. As parcelas foram locadas em povoamentos de Eucalyptus grandis Hill ex Maiden. plantados entre 1991 e 1994, com espaçamento inicial de 3 x 2 m, localizados na região conhecida como “norte-pioneiro” do estado do Paraná. O modelo de Clutter foi utilizado para simular o crescimento e a produção prognosticando o volume total e o volume comercial. Como resultado, foi construída uma tabela de produção de área basal, volume total e volume comercial, ao longo dos anos para as diferentes classes de sítio. Pelas análises realizadas pode-se concluir que o sistema baseado no modelo de Clutter foi eficiente para estimar a produção futura de povoamentos não desbastados de Eucalyptus grandis Hill ex Maiden. na região nordeste do Paraná.

  12. A school-based oral health educational program: the experience of Maringa- PR, Brazil Programa educacional em saúde bucal baseado em escolas: a experiência de Maringá- PR, Brasil

    Directory of Open Access Journals (Sweden)

    Carlos Alberto Conrado

    2004-03-01

    çados sugerem uma encorajadora tendência de melhoria nos níveis de cuidados em saúde bucal entre os jovens em idade escolar estudados. Eles, também, apontam para a necessidade de se intensificar o preparo das professoras em tópicos relacionados à saúde bucal, bem como a instrução das mães para os cuidados apropriados com a saúde bucal. Além disso, eles evidenciam a importância da contínua implementação de programas baseados em escolas para a promoção da saúde bucal.

  13. Biosolids effectiveness to yield ryegrass based on their nitrogen content Eficiência de biossólidos na produção de azevém baseado no conteúdo de nitrogênio

    Directory of Open Access Journals (Sweden)

    Rodrigo Studart Corrêa

    2005-06-01

    Full Text Available Biosolids have been reported to increase yields and supply plant nutrients. However, complying with health and environmental standards is necessary before applying biosolids to land. Thus, sludge stabilization is required to make biosolids safe enough for their agricultural use. Side effects of stabilization processes on agronomic features of sewage sludge are not quite known, although their understanding is essential for biosolids management. Based on a model equivalent to the Mitscherlich equation, effects of the most common processes for sludge stabilization were evaluated (composting, liming, heat-drying and solar irradiation in relation to the agronomic effectiveness of biosolids to yield Lolium perenne L. on two tropical soils, with NH4H2PO4 as a reference. Sewage stabilization processes have affected the ability of biosolids to promote plant growth. Their effectiveness was usually higher than fertilizer in a Spodosol and lower in an Oxisol. Solar-irradiated sludge presented the highest effectiveness among the biosolids and reached peak yields at the lowest application rate independent on soil type. Biosolids could efficiently substitute fertilizers and even yield more plant dry matter than the NH4H2PO4 reference, depending on the biosolid and soil type.Biossólidos têm sido citados como capazes de aumentar a produção de culturas e suprir nutrientes para plantas. Questões sanitárias e ambientais demandam que eles sejam estabilizados para que sejam usados na agricultura. Os efeitos dos processos de estabilização sobre as propriedades agronômicas de biossólidos não são completamente conhecidos, apesar de essenciais para o seu manejo. Baseado em um modelo equivalente à equação de Mitscherlich, este trabalho avaliou os efeitos dos processos mais comuns para a estabilização de lodos de esgotos (compostagem, caleação, secagem térmica e irradiação solar sobre a eficiência agronômica de biossólidos na produção de Lolium

  14. Use of TANDEM methodology for quality control in radiation protection; Aplicacao de metodologia TANDEM para controle de qualidade em radioprotecao

    Energy Technology Data Exchange (ETDEWEB)

    Mello, O.A.; Oliveira, I.R.; Leyton, F.; Nogueira, M.S., E-mail: mnogueira@cdtn.br [Centro de Desenvolvimeto da Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil); Borges, F.L.S., E-mail: flavialuizaborges@yahoo.com.br [Vigilancia Sanitaria de Minas Gerais, Belo Horizonte, MG (Brazil); Joana, G.S., E-mail: georgia.joana@gmail.com [Universidade Federal de Minas Gerais (DEN/UFMG), Belo Horizonte, MG (Brazil)

    2014-07-01

    Recent studies have indicated the increase of the incidence of lens opacities for low radiation doses. Considering epidemiological data, the International Commission on Radiological Protection (ICRP) issued a statement that changed the absorbed dose threshold for the eye lens. The statement also recommends a reduction in the dose limits to the eye lens for occupationally exposed persons; now it is considered to be 20 mSv in a year averaged over five years. For this research two types of thermoluminescent dosimeters TL were used in the construction of the curve tandem. (LiF-100H e LiF-200). For system calibration three monitors were irradiated for each radiation beam. The monitors were irradiated with 4 mGy kerma at 1.5 m from the focal point. The Tandem curve was obtained by the ratio between the values of the energy dependence curves of each dosimeter. Data obtained for the corresponding x-ray beams to radiation reference N60 to N120 are more accurate for determining the energy - steepest part of the curve. The results are shown similar to similar studies and confirm the possibility of using the method for determining the unknown energy radiation fields. (author)

  15. 76 FR 40935 - Vertical Tandem Lifts in Marine Terminals; Extension of the Office of Management and Budget's...

    Science.gov (United States)

    2011-07-12

    ... Occupational Safety and Health Administration Vertical Tandem Lifts in Marine Terminals; Extension of the... collection requirements contained in the Standard on Vertical Tandem Lifts (VTLs) in Marine Terminals (29 CFR... on Vertical Tandem Lifts for Marine Terminals (29 CFR part 1917). OSHA is proposing to increase the...

  16. The Kinetic Stabilizer: A Route to Simpler Tandem Mirror Systems?

    Energy Technology Data Exchange (ETDEWEB)

    Post, R

    2001-05-30

    This paper discusses a new approach to an MHD stabilizing technique for magnetic fusion systems of the axisymmetric ''open-ended'' variety. The concept is adaptable to tandem-mirror systems and would result in a major simplification of such systems, accompanied by a substantial improvement in their confinement characteristics, The paper first discusses the present impetus to find a simpler and less expensive route to fusion than that offered by the mainline approach, the tokamak. The history of magnetic fusion research shows that closed and open systems exhibit very different confinement characteristics. Closed systems, such as the tokamak, the stellarator, or the reversed-field pinch have cross-field transport that is dominated by plasma turbulence. By contrast, there are examples of open-systems where turbulence, if present at all, was at such low levels that the transport agreed with ''classical'' predictions. The clearest examples are ones in which the field geometry was axiymmetric. However axisymmetric mirror systems are subject to MHD instability. Thus in the years following the famous Ioffe experiment, most open systems have employed asymmetric magnetic fields, with attendant problems of complexity and enhanced cross-field transport. This paper proposes a new means of stabilizing axisymmetric mirror-based systems. The idea, called the ''Kinetic Stabilizer'' has roots in experiments performed with the axisymmetric Gas Dynamic Trap at Novosibirsk. In these experiments, performed in a high collisionality plasma regime, it was shown that the presence of the effluent plasma in the positive-curvature expanding-field region outside the mirrors was effective in stabilizing a high-beta (30 percent) confined plasma against MHD modes. In the plasmas of tandem-mirror systems the density of the effluent plasma is too low to employ this method of stabilization. The Kinetic Stabilizer solves this problem by using

  17. Alternate Routing in Tandem Traffic-Groomed Optical Networks

    Directory of Open Access Journals (Sweden)

    Alicia Nicki Washington

    2007-09-01

    Full Text Available Recent advances in telecommunication networks have allowed WDM to emerge as a viable solution to the ever-increasing demands of the Internet. Because these networks carry large amounts of traffic, alternate routing methods are designed in order to allow traffic to be properly re-routed from source to destination in the event of certain events, such as link blocking or failure. In this paper, we consider a tandem traffic-groomed optical network, modeled as a multi-level overflow system, where each level represents a wavelength between adjacent nodes. The queueing network is analyzed using a combination of methods. As will be shown, the decomposition method provides a good approximate analysis of large overflow systems supporting traffic from multiple sources.

  18. Features-Based Deisotoping Method for Tandem Mass Spectra

    Directory of Open Access Journals (Sweden)

    Zheng Yuan

    2011-01-01

    Full Text Available For high-resolution tandem mass spectra, the determination of monoisotopic masses of fragment ions plays a key role in the subsequent peptide and protein identification. In this paper, we present a new algorithm for deisotoping the bottom-up spectra. Isotopic-cluster graphs are constructed to describe the relationship between all possible isotopic clusters. Based on the relationship in isotopic-cluster graphs, each possible isotopic cluster is assessed with a score function, which is built by combining nonintensity and intensity features of fragment ions. The non-intensity features are used to prevent fragment ions with low intensity from being removed. Dynamic programming is adopted to find the highest score path with the most reliable isotopic clusters. The experimental results have shown that the average Mascot scores and F-scores of identified peptides from spectra processed by our deisotoping method are greater than those by YADA and MS-Deconv software.

  19. Sequencing of Oligourea Foldamers by Tandem Mass Spectrometry

    Science.gov (United States)

    Bathany, Katell; Owens, Neil W.; Guichard, Gilles; Schmitter, Jean-Marie

    2013-03-01

    This study is focused on sequence analysis of peptidomimetic helical oligoureas by means of tandem mass spectrometry, to build a basis for de novo sequencing for future high-throughput combinatorial library screening of oligourea foldamers. After the evaluation of MS/MS spectra obtained for model compounds with either MALDI or ESI sources, we found that the MALDI-TOF-TOF instrument gave more satisfactory results. MS/MS spectra of oligoureas generated by decay of singly charged precursor ions show major ion series corresponding to fragmentation across both CO-NH and N'H-CO urea bonds. Oligourea backbones fragment to produce a pattern of a, x, b, and y type fragment ions. De novo decoding of spectral information is facilitated by the occurrence of low mass reporter ions, representative of constitutive monomers, in an analogous manner to the use of immonium ions for peptide sequencing.

  20. Sulphur hexafluoride as a stripper gas for tandem accelerators

    Science.gov (United States)

    Hotchkis, M. A. C.; Child, D.; Fink, D.; Garton, D.; Levchenko, V.; Wilcken, K.

    2013-05-01

    We have investigated sulphur hexafluoride as a stripper gas in tandem accelerators by using the ANTARES accelerator system at ANSTO to measure charge state distributions for this gas. Results are reported at 4 MV terminal voltage for injected negative ions ranging from carbon to uranium oxide. For iodine and thorium the distributions are extended across a range of energies of practical use for accelerator mass spectrometry, ion beam analysis and other accelerator applications. Charge state distributions using sulphur hexafluoride are found to have mean charge states up to 1 charge unit higher than, and to be broader than, corresponding distributions for argon gas, except in the case of carbon beams. As a result, SF6 is shown to provide significantly higher yields for charge states of heavy ions above the mean charge state. We now perform actinide AMS measurements with 9% yield to the 5+ charge state, compared to 4-5% achieved previously with argon gas.

  1. United theory of planet formation (i): Tandem regime

    Science.gov (United States)

    Ebisuzaki, Toshikazu; Imaeda, Yusuke

    2017-07-01

    The present paper is the first one of a series of papers that present the new united theory of planet formation, which includes magneto-rotational instability and porous aggregation of solid particles in an consistent way. We here describe the ;tandem; planet formation regime, in which a solar system like planetary systems are likely to be produced. We have obtained a steady-state, 1-D model of the accretion disk of a protostar taking into account the magneto-rotational instability (MRI) and and porous aggregation of solid particles. We find that the disk is divided into an outer turbulent region (OTR), a MRI suppressed region (MSR), and an inner turbulent region (ITR). The outer turbulent region is fully turbulent because of MRI. However, in the range, rout(= 8 - 60 AU) from the central star, MRI is suppressed around the midplane of the gas disk and a quiet area without turbulence appears, because the degree of ionization of gas becomes low enough. The disk becomes fully turbulent again in the range rin(= 0.2 - 1 AU), which is called the inner turbulent region, because the midplane temperature become high enough (>1000 K) due to gravitational energy release. Planetesimals are formed through gravitational instability at the outer and inner MRI fronts (the boundaries between the MRI suppressed region (MSR) and the outer and inner turbuent regions) without particle enhancement in the original nebula composition, because of the radial concentration of the solid particles. At the outer MRI front, icy particles grow through low-velocity collisions into porous aggregates with low densities (down to ∼10-5 gcm-3). They eventually undergo gravitational instability to form icy planetesimals. On the other hand, rocky particles accumulate at the inner MRI front, since their drift velocities turn outward due to the local maximum in gas pressure. They undergo gravitational instability in a sub-disk of pebbles to form rocky planetesimals at the inner MRI front. They are likely

  2. Automatic validation of phosphopeptide identifications from tandem mass spectra.

    Science.gov (United States)

    Lu, Bingwen; Ruse, Cristian; Xu, Tao; Park, Sung Kyu; Yates, John

    2007-02-15

    We developed and compared two approaches for automated validation of phosphopeptide tandem mass spectra identified using database searching algorithms. Phosphopeptide identifications were obtained through SEQUEST searches of a protein database appended with its decoy (reversed sequences). Statistical evaluation and iterative searches were employed to create a high-quality data set of phosphopeptides. Automation of postsearch validation was approached by two different strategies. By using statistical multiple testing, we calculate a p value for each tentative peptide phosphorylation. In a second method, we use a support vector machine (SVM; a machine learning algorithm) binary classifier to predict whether a tentative peptide phosphorylation is true. We show good agreement (85%) between postsearch validation of phosphopeptide/spectrum matches by multiple testing and that from support vector machines. Automatic methods conform very well with manual expert validation in a blinded test. Additionally, the algorithms were tested on the identification of synthetic phosphopeptides. We show that phosphate neutral losses in tandem mass spectra can be used to assess the correctness of phosphopeptide/spectrum matches. An SVM classifier with a radial basis function provided classification accuracy from 95.7% to 96.8% of the positive data set, depending on search algorithm used. Establishing the efficacy of an identification is a necessary step for further postsearch interrogation of the spectra for complete localization of phosphorylation sites. Our current implementation performs validation of phosphoserine/phosphothreonine-containing peptides having one or two phosphorylation sites from data gathered on an ion trap mass spectrometer. The SVM-based algorithm has been implemented in the software package DeBunker. We illustrate the application of the SVM-based software DeBunker on a large phosphorylation data set.

  3. Tandem demodulation lock-in amplifier based on digital signal processor for dual-modulated spectroscopy.

    Science.gov (United States)

    Qin, Jianhuan; Huang, Zhiming; Ge, Yujian; Hou, Yun; Chu, Junhao

    2009-03-01

    Dual-modulated spectroscopy is one of the most powerful methods in the measurement of modulation spectroscopy. Here we develop a tandem lock-in amplifier (LIA) based on digital signal processor to implement a novel algorithm of tandem demodulation. The theoretical analysis of demodulation algorithm is presented, and the implementation of this tandem LIA is described in detail. Compared to the traditional demodulating way with two LIAs in cascade, this tandem LIA eliminates the extra quantization error of redundant analog-to-digital and digital-to-analog conversions and removes the limitation to the time constant in the commercial LIA, hence lowers the requirement of frequency ratio in dual-modulated spectroscopy. The applications are given as examples in the photoreflectance (PR) measurements of GaAs (100) thin film and GaSb bulk material, respectively, at the different optical energy regions. The experimental results indicate that this tandem is well capable of PR spectra measurement with good PR lineshapes and reasonable signal noise ratio. A brief comparison of GaAs PR results between tandem LIA and two LIAs is made to prove the efficiency and advantages of the tandem LIA.

  4. Tunable color parallel tandem organic light emitting devices with carbon nanotube and metallic sheet interlayers

    Energy Technology Data Exchange (ETDEWEB)

    Oliva, Jorge; Desirena, Haggeo; De la Rosa, Elder [Centro de Investigaciones en Optica, A.P. 1-948, León, Guanajuato 37160 (Mexico); Papadimitratos, Alexios [Solarno Inc., Coppell, Texas 75019 (United States); University of Texas at Dallas, Richardson, Texas 75080 (United States); Zakhidov, Anvar A., E-mail: Zakhidov@utdallas.edu [Solarno Inc., Coppell, Texas 75019 (United States); University of Texas at Dallas, Richardson, Texas 75080 (United States); Energy Efficiency Center, National University of Science and Technology, MISiS, Moscow 119049 (Russian Federation)

    2015-11-21

    Parallel tandem organic light emitting devices (OLEDs) were fabricated with transparent multiwall carbon nanotube sheets (MWCNT) and thin metal films (Al, Ag) as interlayers. In parallel monolithic tandem architecture, the MWCNT (or metallic films) interlayers are an active electrode which injects similar charges into subunits. In the case of parallel tandems with common anode (C.A.) of this study, holes are injected into top and bottom subunits from the common interlayer electrode; whereas in the configuration of common cathode (C.C.), electrons are injected into the top and bottom subunits. Both subunits of the tandem can thus be monolithically connected functionally in an active structure in which each subunit can be electrically addressed separately. Our tandem OLEDs have a polymer as emitter in the bottom subunit and a small molecule emitter in the top subunit. We also compared the performance of the parallel tandem with that of in series and the additional advantages of the parallel architecture over the in-series were: tunable chromaticity, lower voltage operation, and higher brightness. Finally, we demonstrate that processing of the MWCNT sheets as a common anode in parallel tandems is an easy and low cost process, since their integration as electrodes in OLEDs is achieved by simple dry lamination process.

  5. Detection of dispersed short tandem repeats using reversible jump Markov chain Monte Carlo.

    Science.gov (United States)

    Liang, Tong; Fan, Xiaodan; Li, Qiwei; Li, Shuo-Yen R

    2012-10-01

    Tandem repeats occur frequently in biological sequences. They are important for studying genome evolution and human disease. A number of methods have been designed to detect a single tandem repeat in a sliding window. In this article, we focus on the case that an unknown number of tandem repeat segments of the same pattern are dispersively distributed in a sequence. We construct a probabilistic generative model for the tandem repeats, where the sequence pattern is represented by a motif matrix. A Bayesian approach is adopted to compute this model. Markov chain Monte Carlo (MCMC) algorithms are used to explore the posterior distribution as an effort to infer both the motif matrix of tandem repeats and the location of repeat segments. Reversible jump Markov chain Monte Carlo (RJMCMC) algorithms are used to address the transdimensional model selection problem raised by the variable number of repeat segments. Experiments on both synthetic data and real data show that this new approach is powerful in detecting dispersed short tandem repeats. As far as we know, it is the first work to adopt RJMCMC algorithms in the detection of tandem repeats.

  6. Flow characteristics of the two tandem wavy cylinders and drag reduction phe-nomenon

    Institute of Scientific and Technical Information of China (English)

    邹琳; 郭丛波; 熊灿

    2013-01-01

    This paper presents an extensive numerical study of 3-D laminar flow around two wavy cylinders in the tandem arrangement for spacing ratios (L/Dm ) ranging from 1.5 to 5.5 at a low Reynolds number of 100. The investigation focuses on the effects of spacing ratio (L/Dm ) and wavy surface on the 3-D near wake flow patterns, the force and pressure coefficients and the vortex shedding frequency for the two tandem wavy cylinders. Flows around the two tandem circular cylinders are also obtained for comparison. With the spacing ratio in the range of L/Dm=1.5-5.5 , unlike two tandem circular cylinders, the wavy cylinders in the tandem arrangement do not have the wake interference behaviour of three basic types. The vortex shedding behind the upstream wavy cylinder occurs at a further downstream position as compared with that of the upstream circular cylinder. This leads to the weakening of the effect of the vibration of the cylinders as well as a distinct drag reduction. The effects of the drag reduction and the control of the vibration of the two wavy cylinders in tandem become more and more evident when L/Dm³4.0, with a distinct vortex shedding in the upstream cylinder regime for the two circular cylinders in tandem.

  7. Targeted tandem duplication of a large chromosomal segment in Aspergillus oryzae.

    Science.gov (United States)

    Takahashi, Tadashi; Sato, Atsushi; Ogawa, Masahiro; Hanya, Yoshiki; Oguma, Tetsuya

    2014-08-01

    We describe here the first successful construction of a targeted tandem duplication of a large chromosomal segment in Aspergillus oryzae. The targeted tandem chromosomal duplication was achieved by using strains that had a 5'-deleted pyrG upstream of the region targeted for tandem chromosomal duplication and a 3'-deleted pyrG downstream of the target region. Consequently,strains bearing a 210-kb targeted tandem chromosomal duplication near the centromeric region of chromosome 8 and strains bearing a targeted tandem chromosomal duplication of a 700-kb region of chromosome 2 were successfully constructed. The strains bearing the tandem chromosomal duplication were efficiently obtained from the regenerated protoplast of the parental strains. However, the generation of the chromosomal duplication did not depend on the introduction of double-stranded breaks(DSBs) by I-SceI. The chromosomal duplications of these strains were stably maintained after five generations of culture under nonselective conditions. The strains bearing the tandem chromosomal duplication in the 700-kb region of chromosome 2 showed highly increased protease activity in solid-state culture, indicating that the duplication of large chromosomal segments could be a useful new breeding technology and gene analysis method.

  8. Tandem gene arrays in Trypanosoma brucei: Comparative phylogenomic analysis of duplicate sequence variation

    Directory of Open Access Journals (Sweden)

    Jackson Andrew P

    2007-04-01

    Full Text Available Abstract Background The genome sequence of the protistan parasite Trypanosoma brucei contains many tandem gene arrays. Gene duplicates are created through tandem duplication and are expressed through polycistronic transcription, suggesting that the primary purpose of long, tandem arrays is to increase gene dosage in an environment where individual gene promoters are absent. This report presents the first account of the tandem gene arrays in the T. brucei genome, employing several related genome sequences to establish how variation is created and removed. Results A systematic survey of tandem gene arrays showed that substantial sequence variation existed across the genome; variation from different regions of an array often produced inconsistent phylogenetic affinities. Phylogenetic relationships of gene duplicates were consistent with concerted evolution being a widespread homogenising force. However, tandem duplicates were not usually identical; therefore, any homogenising effect was coincident with divergence among duplicates. Allelic gene conversion was detected using various criteria and was apparently able to both remove and introduce sequence variation. Tandem arrays containing structural heterogeneity demonstrated how sequence homogenisation and differentiation can occur within a single locus. Conclusion The use of multiple genome sequences in a comparative analysis of tandem gene arrays identified substantial sequence variation among gene duplicates. The distribution of sequence variation is determined by a dynamic balance of conservative and innovative evolutionary forces. Gene trees from various species showed that intraspecific duplicates evolve in concert, perhaps through frequent gene conversion, although this does not prevent sequence divergence, especially where structural heterogeneity physically separates a duplicate from its neighbours. In describing dynamics of sequence variation that have consequences beyond gene dosage, this

  9. Design optimization of thin-film/wafer-based tandem junction solar cells using analytical modeling

    Science.gov (United States)

    Davidson, Lauren; Toor, Fatima

    2016-03-01

    Several research groups are developing solar cells of varying designs and materials that are high efficiency as well as cost competitive with the single junction silicon (Si) solar cells commercially produced today. One of these solar cell designs is a tandem junction solar cell comprised of perovskite (CH3NH3PbI3) and silicon (Si). Loper et al.1 was able to create a 13.4% efficient tandem cell using a perovskite top cell and a Si bottom cell, and researchers are confident that the perovskite/Si tandem cell can be optimized in order to reach higher efficiencies without introducing expensive manufacturing processes. However, there are currently no commercially available software capable of modeling a tandem cell that is based on a thin-film based bottom cell and a wafer-based top cell. While PC1D2 and SCAPS3 are able to model tandem cells comprised solely of thin-film absorbers or solely of wafer-based absorbers, they result in convergence errors if a thin-film/wafer-based tandem cell, such as the perovskite/ Si cell, is modeled. The Matlab-based analytical model presented in this work is capable of modeling a thin-film/wafer-based tandem solar cell. The model allows a user to adjust the top and bottom cell parameters, such as reflectivity, material bandgaps, donor and acceptor densities, and material thicknesses, in order to optimize the short circuit current, open circuit voltage, and quantum efficiency of the tandem solar cell. Using the Matlab-based analytical model, we were able optimize a perovskite/Si tandem cell with an efficiency greater than 30%.

  10. Roll-to-roll processed polymer tandem solar cells partially processed from water

    DEFF Research Database (Denmark)

    Larsen-Olsen, Thue Trofod; Andersen, Thomas Rieks; Andreasen, Birgitta

    2012-01-01

    included water, alcohols and chlorobenzene. Open-circuit voltages close to the expected sum of sub cell voltages were achieved, while the overall efficiency of the tandem cells was found to be limited by the low yielding back cell, which was processed from water based ink. Many of the challenges associated......Large area polymer tandem solar cells completely processed using roll-to-roll (R2R) coating and printing techniques are demonstrated. A stable tandem structure was achieved by the use of orthogonal ink solvents for the coating of all layers, including both active layers. Processing solvents...

  11. An approach for configuring space photovoltaic tandem arrays based on cell layer performance

    Science.gov (United States)

    Flora, C. S.; Dillard, P. A.

    1991-01-01

    Meeting solar array performance goals of 300 W/Kg requires use of solar cells with orbital efficiencies greater than 20 percent. Only multijunction cells and cell layers operating in tandem produce this required efficiency. An approach for defining solar array design concepts that use tandem cell layers involve the following: transforming cell layer performance at standard test conditions to on-orbit performance; optimizing circuit configuration with tandem cell layers; evaluating circuit sensitivity to cell current mismatch; developing array electrical design around selected circuit; and predicting array orbital performance including seasonal variations.

  12. Boosting the Efficiency of III-V/Si Tandem Solar Cells

    Energy Technology Data Exchange (ETDEWEB)

    Essig, Stephanie; Allebe, Christophe; Geisz, John F.; Steiner, Myles A.; Paviet-Salomon, Bertrand; Descoeudres, Antoine; Tamboli, Adele; Barraud, Loris; Ward, Scott; Badel, Nicolas; LaSalvia, Vincenzo; Levrat, Jacques; Despeisse, Matthieu; Ballif, Christophe; Stradins, Paul; Young, David L.

    2016-11-21

    We have developed Si-based tandem solar cells with a certified 1-sun efficiency of 29.8% (AM1.5g). The four-terminal tandem devices consist of 1.8 eV rear-heterojunction GaInP top cells and silicon heterojunction bottom cells. The two subcells were fabricated independently in two different labs and merged using an optically transparent, electrically insulating epoxy. Work is ongoing to further improve the performance of each subcell and to push the tandem cell efficiency to > 30%.

  13. Preprocessing of Tandem Mass Spectrometric Data Based on Decision Tree Classification

    Institute of Scientific and Technical Information of China (English)

    Jing-Fen Zhang; Si-Min He; Jin-Jin Cai; Xing-Jun Cao; Rui-Xiang Sun; Yan Fu; Rong Zeng; Wen Gao

    2005-01-01

    In this study, we present a preprocessing method for quadrupole time-of-flight(Q-TOF) tandem mass spectra to increase the accuracy of database searching for peptide (protein) identification. Based on the natural isotopic information inherent in tandem mass spectra, we construct a decision tree after feature selection to classify the noise and ion peaks in tandem spectra. Furthermore, we recognize overlapping peaks to find the monoisotopic masses of ions for the following identification process. The experimental results show that this preprocessing method increases the search speed and the reliability of peptide identification.

  14. Energy efficiency project: continuous rolling mill profiles plant of Barra Mansa Votorantim Siderurgia; Projeto de eficiencia energetica: laminador continuo de perfis da Usina Barra Mansa Votorantim Siderurgia

    Energy Technology Data Exchange (ETDEWEB)

    Decnop, Luiz Eduardo Machado [LD Engenharia Ltda, Belo Horizonte, MG (Brazil); Franca, Rafael Latini; Silva, Bruno Jose Carvalho; Antunes, Raphael Jose Simoes [Votorantim Siderurgia, Volta Redonda, RJ (Brazil)

    2011-12-21

    This work shows the development and implementation of a plan to increase energy efficiency and consequent reduction in production costs of profiles. The plant has a varied mix, large differences among products (1 kg/m to 30 kg/m) that resulting in a large gaps between bars and high level of interruption. It was necessary to reduce the impacts of fixed charges that weighed heavily in the cost. The methodology was to identify, among the main elements contributing to the consumption of electricity, what is the real need of each input as the quality, quantity, intensity and permanence, to perform strictly their intended function in the process. Then the comparison of these results with the engineering solutions adopted in the current design of the equipment. Thus was taken to waste all resources available beyond the strict needs. This ranking conducted the study to optimize the delivery of each resource taking into account the difficulty and risk of possible technical solutions, taking as a premise to develop definitive solutions with full automation of security functions to ensure stability and security of gains. The results were the reduction of 147 kWh/t to 105 kWh/t in the LCP (-37%), and a 50% reduction in energy expended in the WTP. (author)

  15. Alcance y límites de un currículo basado en competencias Alcance e limites de um currículo baseado em competências The Scope and Limitations of a Competency-based Curriculum

    Directory of Open Access Journals (Sweden)

    Manuel Ignacio Gonzales-Bernal

    2008-06-01

    Full Text Available El presente texto constituye la segunda parte del informe de investigación "Currículum basado en competencias: una experiencia en educación universitaria", publicado en el volumen 9, No. 2-año 2006. A través de la investigación realizada se pretendió evaluar la implementación de la reforma curricular de la Facultad de Comunicación de la Universidad de La Sabana, analizando diferentes variables en el área de Comunicación Pública. El trabajo se enmarca dentro del diseño conocido como investigación evaluativa, y el enfoque aplicado es el modelo de enfoque dominante, en donde se privilegió el corte cualitativo y de tipo descriptivo. En esta parte del informe se muestra el análisis de resultados, las conclusiones y las recomendaciones. El análisis se hace retomando las respuestas que cada uno de los públicos consultados dio, al ser indagado sobre las variables incluidas en el estudio. De igual manera, se hace un análisis documental, a través de un sistema de matrices, y, finalmente, se hace un cruce de la información, utilizando una tabla de triple entrada, que permite desplegar los resultados de cada una de las fuentes. La interpretación de resultados, las conclusiones y las recomendaciones se formulan a la a luz del marco teórico que sustenta la investigación.Este texto é a segunda parte do relatório da pesquisa "Currículo baseado nas competências: uma experiência na educação universitária", publicado no volume 9, No. 2, de 2006. Pretendeu-se avaliar a implantação da reforma curricular na Faculdade de Comunicação da Universidad de La Sabana analisando diversas variáveis na área da comunicação pública. O trabalho é encaixado na pesquisa avaliativa e o enfoque dominante, privilegiando o tipo qualitativo e descritivo. Esta parte do relatório refere-se à análise dos resultados, as conclusões e as recomendações. A análise é feita retomando as respostas dadas pelos públicos indagados sobre as vari

  16. Identification of protein interacting partners using tandem affinity purification.

    Science.gov (United States)

    Bailey, Dalan; Urena, Luis; Thorne, Lucy; Goodfellow, Ian

    2012-02-25

    A critical and often limiting step in understanding the function of host and viral proteins is the identification of interacting cellular or viral protein partners. There are many approaches that allow the identification of interacting partners, including the yeast two hybrid system, as well as pull down assays using recombinant proteins and immunoprecipitation of endogenous proteins followed by mass spectrometry identification(1). Recent studies have highlighted the utility of double-affinity tag mediated purification, coupled with two specific elution steps in the identification of interacting proteins. This approach, termed Tandem Affinity Purification (TAP), was initially used in yeast(2,3) but more recently has been adapted to use in mammalian cells(4-8). As proof-of-concept we have established a tandem affinity purification (TAP) method using the well-characterized eukaryotic translation initiation factor eIF4E(9,10).The cellular translation factor eIF4E is a critical component of the cellular eIF4F complex involved in cap-dependent translation initiation(10). The TAP tag used in the current study is composed of two Protein G units and a streptavidin binding peptide separated by a Tobacco Etch Virus (TEV) protease cleavage sequence. The TAP tag used in the current study is composed of two Protein G units and a streptavidin binding peptide separated by a Tobacco Etch Virus (TEV) protease cleavage sequence(8). To forgo the need for the generation of clonal cell lines, we developed a rapid system that relies on the expression of the TAP-tagged bait protein from an episomally maintained plasmid based on pMEP4 (Invitrogen). Expression of tagged murine eIF4E from this plasmid was controlled using the cadmium chloride inducible metallothionein promoter. Lysis of the expressing cells and subsequent affinity purification via binding to rabbit IgG agarose, TEV protease cleavage, binding to streptavidin linked agarose and subsequent biotin elution identified numerous

  17. Numerical Investigation of the Performance of an Axial-Flow Pump with Tandem Blades

    Institute of Scientific and Technical Information of China (English)

    YU Zhi-yi; LIU Shu-yan; WANG Guo-yu

    2007-01-01

    The performance characteristics of an axial-flow pump with tandem blades are studied based on the numerical computations. The arrangement of the pump impellers is established through the analysis of velocity triangles. With the commercial computational fluid dynamics (CFD) software NUMECA, the turbulent flow in the tandem axial-flow pump is simulated in various flow conditions. The detail flow structure in the leading edge region of the rear impeller is described, and the i nfluence of the deflection angle of the rear blade on the head performance is studied. According to the simulation, the performance comparison is made between the tandem axial-flow pump and the conventional two-stage axial-flow pump with a uniform impeller size. Results of the study indicate that the tandem axial-flow pump can work in a wider range with high efficiency.

  18. Interpreting the need for initial support to perform tandem stance tests of balance

    NARCIS (Netherlands)

    Hile, E.S.; Brach, J.S.; Perera, S.; Wert, D.M.; VanSwearingen, J.M.; Studenski, S.A.

    2012-01-01

    BACKGROUND: Geriatric rehabilitation reimbursement increasingly requires documented deficits on standardized measures. Tandem stance performance can characterize balance, but protocols are not standardized. Objective The purpose of this study was to explore the impact of: (1) initial support to stab

  19. Air-processed organic tandem solar cells on glass: toward competitive operating lifetimes

    DEFF Research Database (Denmark)

    Adams, Jens; Spyropoulos, George D.; Salvador, Michael

    2015-01-01

    efficiencies of more than 10% the rather limited stability of this type of devices raises concerns towards future commercialization. The tandem concept allows for both absorbing a broader range of the solar spectrum and reducing thermalization losses. We designed an organic tandem solar cell with an inverted...... for long operating lifetimes consists of periodic UV light treatment. These results suggest that new material approaches towards UV-resilient active and interfacial layers may enable efficient organic tandem solar cells with lifetimes competitive with traditional inorganic photovoltaics....... device geometry comprising environmentally stable active and charge-selecting layers. Under continuous white light irradiation, we demonstrate an extrapolated, operating lifetime in excess of one decade. We elucidate that for the current generation of organic tandem cells one critical requirement...

  20. A novel organic-inorganic hybrid tandem solar cell with inverted structure

    Science.gov (United States)

    Bahrami, A.; Faez, R.

    2017-04-01

    A novel organic-inorganic hybrid tandem solar cell with inverted structure is proposed. This efficient double-junction hybrid tandem solar cell consists of a single-junction hydrogenated amorphous silicon (a-Si:H) subcell with n-i-p structure as front cell and a P3HT:PCBM organic subcell with inverted structure as back cell. In order to optimize the hybrid tandem cell, we have performed a simulation based on transfer matrix method. We have compared the characteristics of this novel structure with a conventional structure. As a result, a power conversion efficiency (PCE) of 6.1 and 24% improvement compared to the conventional hybrid tandem cell was achieved. We also discuss the high potential of this novel structure for realizing high-stability organic-inorganic hybrid photovoltaic devices.

  1. Highly efficient tandem polymer solar cells with a photovoltaic response in the visible light range.

    Science.gov (United States)

    Zheng, Zhong; Zhang, Shaoqing; Zhang, Maojie; Zhao, Kang; Ye, Long; Chen, Yu; Yang, Bei; Hou, Jianhui

    2015-02-18

    Highly efficient polymer solar cells with a tandem structure are fabricated by using two excellent photovoltaic polymers and a highly transparent intermediate recombination layer. Power conversion -efficiencies over 10% can be realized with a photovoltaic response within 800 nm.

  2. Hybrid tandem solar cells with depleted-heterojunction quantum dot and polymer bulk heterojunction subcells

    KAUST Repository

    Kim, Taesoo

    2015-10-01

    We investigate hybrid tandem solar cells that rely on the combination of solution-processed depleted-heterojunction colloidal quantum dot (CQD) and bulk heterojunction polymer:fullerene subcells. The hybrid tandem solar cell is monolithically integrated and electrically connected in series with a suitable p-n recombination layer that includes metal oxides and a conjugated polyelectrolyte. We discuss the monolithic integration of the subcells, taking into account solvent interactions with underlayers and associated constraints on the tandem architecture, and show that an adequate device configuration consists of a low bandgap CQD bottom cell and a high bandgap polymer:fullerene top cell. Once we optimize the recombination layer and individual subcells, the hybrid tandem device reaches a VOC of 1.3V, approaching the sum of the individual subcell voltages. An impressive fill factor of 70% is achieved, further confirming that the subcells are efficiently connected via an appropriate recombination layer. © 2015.

  3. Tandem-structured, hot electron based photovoltaic cell with double Schottky barriers.

    Science.gov (United States)

    Lee, Young Keun; Lee, Hyosun; Park, Jeong Young

    2014-04-03

    We demonstrate a tandem-structured, hot electron based photovoltaic cell with double Schottky barriers. The tandem-structured, hot electron based photovoltaic cell is composed of two metal/semiconductor interfaces. Two types of tandem cells were fabricated using TiO2/Au/Si and TiO2/Au/TiO2, and photocurrent enhancement was detected. The double Schottky barriers lead to an additional pathway for harvesting hot electrons, which is enhanced through multiple reflections between the two barriers with different energy ranges. In addition, light absorption is improved by the band-to-band excitation of both semiconductors with different band gaps. Short-circuit current and energy conversion efficiency of the tandem-structured TiO2/Au/Si increased by 86% and 70%, respectively, compared with Au/Si metal/semiconductor nanodiodes, showing an overall solar energy conversion efficiency of 5.3%.

  4. Efficiently-designed hybrid tandem photovoltaic with organic and inorganic single cells

    Science.gov (United States)

    Vincent, Premkumar; Bae, Jin-Hyuk; Kim, Hyeok

    2016-05-01

    Conjugated polymers for solar-cell applications have been extensively studied and have proven highly beneficial in tandem solar-cell structures. This study focuses on achieving power conversion efficiencies of greater than 10% when in tandem with a highly efficient copper indium gallium diselenide (CIGS) solar cell. The optimal design is suggested based on the result of optical simulations on the organic-CIGS tandem structure. This is one of the first reports to show theoretically an organic-CIGS tandem solar cell to obtain an efficiency of greater than 10%. The best PCE was at a thickness of 200 nm for PTB7:PCBM, the active layer of the organic solar cell, and 400 nm for CIGS active layer. Our best datum showed an efficiency of 11.41% with a short-circuit current density of 11.56 mA/cm2 and a good spectral response at our optimized thicknesses.

  5. Modeling and Simulation of Tandem Tollbooth Operations with Max-Algebra Approach

    Science.gov (United States)

    Hong, Young-Chae; Kim, Dong-Kyu; Kho, Seung-Young; Kim, Soo Wook; Yang, Hongsuk

    This study proposes a new model to simulate tandem tollbooth system in order to enhance planning and management of toll plaza facilities. A discrete-event stochastic microscopic simulation model is presented and developed to evaluate the operational performance of tandem tollbooth. Traffic behavior is represented using a set of mathematical and logical algorithms. Modified versions of Max-algebra approach are integrated into this new algorithm to simulate traffic operation at toll plazas. Computational results show that the benefit of tandem tollbooth depends on the number of serial tollbooth, service time and reaction time of drivers. The capacity of tandem tollbooth increases when service time follows a normal distribution rather than negative exponential distribution. Specifically, the lower variance of service time is, the better capacity tollbooth has. In addition, the ratio of driver's reaction time to service time affects the increasing ratio of the capacity extended by tollbooth.

  6. Synfuels from fusion: producing hydrogen with the Tandem Mirror Reactor and thermochemical cycles

    Energy Technology Data Exchange (ETDEWEB)

    Werner, R.W.; Ribe, F.L.

    1981-01-21

    This volume contains the following sections: (1) the Tandem Mirror fusion driver, (2) the Cauldron blanket module, (3) the flowing microsphere, (4) coupling the reactor to the process, (5) the thermochemical cycles, and (6) chemical reactors and process units. (MOW)

  7. Analysis of genetic polymorphism of nine short tandem repeat loci in ...

    African Journals Online (AJOL)

    Yomi

    2012-03-15

    Mar 15, 2012 ... Short tandem repeat (STR) is widely used today for gene mapping ... minatory power for some difficult cases, such as complex kinship analysis ... Arlequin version 3.5 software (Computational and Molecular. Population ...

  8. Solving multicomponent chiral separation challenges using a new SFC tandem column screening tool.

    Science.gov (United States)

    Welch, Christopher J; Biba, Mirlinda; Gouker, Joseph R; Kath, Gary; Augustine, Paul; Hosek, Paul

    2007-03-01

    A tool for improved tandem column chiral supercritical fluid chromatography (SFC) method development screening was prepared by modification of a commercial analytical SFC instrument with two different software-controllable, six position high-pressure column selection valves, each controlling a bank of five different columns and a pass through line. The resulting instrument, which has the ability to screen 10 different individual columns and 25 different tandem column arrangements, is a useful tool for facilitating the screening of tandem column SFC arrangements for separation of complex mixtures of stereoisomers or other multicomponent mixtures. Strategies for optimal use of the instrument are discussed, and several examples of the use of the instrument in developing tandem SFC methods for resolution of multicomponent mixtures are presented.

  9. A polymer tandem solar cell with 10.6% power conversion efficiency

    National Research Council Canada - National Science Library

    You, Jingbi; Dou, Letian; Yoshimura, Ken; Kato, Takehito; Ohya, Kenichiro; Moriarty, Tom; Emery, Keith; Chen, Chun-Chao; Gao, Jing; Li, Gang; Yang, Yang

    2013-01-01

    An effective way to improve polymer solar cell efficiency is to use a tandem structure, as a broader part of the spectrum of solar radiation is used and the thermalization loss of photon energy is minimized...

  10. Review of tandem repeat search tools: a systematic approach to evaluating algorithmic performance

    National Research Council Canada - National Science Library

    Lim, Kian Guan; Kwoh, Chee Keong; Hsu, Li Yang; Wirawan, Adrianto

    2013-01-01

    .... Over the last 10-15 years, numerous tools have been developed for searching tandem repeats, but differences in the search algorithms adopted and difficulties with parameter settings have confounded...

  11. Semi-transparent perovskite solar cells for tandems with silicon and CIGS

    KAUST Repository

    Bailie, Colin D.

    2015-01-01

    © 2015 The Royal Society of Chemistry. A promising approach for upgrading the performance of an established low-bandgap solar technology without adding much cost is to deposit a high bandgap polycrystalline semiconductor on top to make a tandem solar cell. We use a transparent silver nanowire electrode on perovskite solar cells to achieve a semi-transparent device. We place the semi-transparent cell in a mechanically-stacked tandem configuration onto copper indium gallium diselenide (CIGS) and low-quality multicrystalline silicon (Si) to achieve solid-state polycrystalline tandem solar cells with a net improvement in efficiency over the bottom cell alone. This work paves the way for integrating perovskites into a low-cost and high-efficiency (>25%) tandem cell.

  12. Synthesis of Carbazoles and Carbazole-Containing Heterocycles via Rhodium-Catalyzed Tandem Carbonylative Benzannulations.

    Science.gov (United States)

    Song, Wangze; Li, Xiaoxun; Yang, Ka; Zhao, Xian-liang; Glazier, Daniel A; Xi, Bao-min; Tang, Weiping

    2016-04-01

    Polycyclic aromatic compounds are important constituents of pharmaceuticals and other materials. We have developed a series of Rh-catalyzed tandem carbonylative benzannulations for the synthesis of tri-, tetra-, and pentacyclic heterocycles from different types of aryl propargylic alcohols. These tandem reactions provide efficient access to highly substituted carbazoles, furocarbazoles, pyrrolocarbazoles, thiophenocarbazoles, and indolocarbazoles. While tricyclic heterocycles could be derived from vinyl aryl propargylic alcohols, tetra- and pentacyclic heterocycles were synthesized from diaryl propargylic alcohols. The tandem carbonylative benzannulation is initiated by a π-acidic rhodium(I) catalyst-mediated nucleophilic addition to alkyne to generate a key metal-carbene intermediate, which is then trapped by carbon monoxide to form a ketene species for 6π electrocyclization. Overall, three bonds and two rings are formed in all of these tandem carbonylative benzannulation reactions.

  13. Partners in crime: The role of tandem modules in gene transcription.

    Science.gov (United States)

    Sharma, Rajal; Zhou, Ming-Ming

    2015-09-01

    Histones and their modifications play an important role in the regulation of gene transcription. Numerous modifications, such as acetylation, phosphorylation, methylation, ubiquitination, and SUMOylation, have been described. These modifications almost always co-occur and thereby increase the combinatorial complexity of post-translational modification detection. The domains that recognize these histone modifications often occur in tandem in the context of larger proteins and complexes. The presence of multiple modifications can positively or negatively regulate the binding of these tandem domains, influencing downstream cellular function. Alternatively, these tandem domains can have novel functions from their independent parts. Here we summarize structural and functional information known about major tandem domains and their histone binding properties. An understanding of these interactions is key for the development of epigenetic therapy.

  14. Experimental verification of optically optimized CuGaSe2 top cell for improving chalcopyrite tandems*

    Directory of Open Access Journals (Sweden)

    Lux-Steiner M. Ch.

    2010-10-01

    Full Text Available An efficient tandem solar cell requires a top cell which is highly transparent below the energy gap of its absorber. Previously we had reported on a theoretically optimized CuGaSe2 top cell stack based on realistic material properties. It promised a significant increase in optical transparency and, consequently, enhanced CuGaSe2/Cu(In,GaSe2 tandem efficiency. Here we present the first steps taken towards the experimental realization of this optimized tandem. We started with a mechanically stacked device which achieved 8.5% efficiency. Optical measurements of the improved top cells and corresponding photo current densities of the filtered bottom cell are reported. The experimental findings are in agreement with the optical modeling. These data are used to assess the level of tandem performance that could be accomplished in the near future and to discuss the priorities of further research.

  15. Nondestructive Evaluation of Double Bevel T-Joint by Tandem Array Ultrasonic Transducer

    Science.gov (United States)

    Shirahata, H.; Miki, C.; Yamaguchi, R.

    2003-03-01

    The double bevel T-joint is one of the most fundamental joints of steel bridges. Double bevel T-joint can be seen at beam-column connection of bridge pier. In the Japanese specifications, the welding should be full penetration. However, weld defect of incomplete penetration could be left in the joint due to the lack of quality control in welding. Fatigue cracks can be propagated from the weld defects. The authors developed a tandem array transducer. The tandem array transducer consists of 10 elements aligned in the same direction. Tandem scanning can be simulated by the transducer. Image reconstruction of incomplete penetration by synthetic aperture focusing technique was carried out. The test results showed sufficient detectability of incomplete penetration by the tandem array transducer. Height of incomplete of penetration could be estimated.

  16. Self-similarity of far wake behind tandem of two disks

    DEFF Research Database (Denmark)

    Okulov, Valery; Litvinov, I. V.; Naumov, I. V.

    2017-01-01

    In this work we used digital particle image visualization (PIV) to experimentally establish the self-similarity of far wake behind a tandem of two disks of a diameter D (300 mm) with a common axis along the incident flow. The research was performed in a water flume (Re ≈ 2 · 105) with variation...... the tandem exceeded the corresponding value for a single disk, being independent of the distance between the disks (L = 4–8D). The velocity fluctuations behind the tandem did not differ much from the level of fluctuations in the case of a single disk up to a distance of forty calibers downstream, where...... the wake ceased to differ from the background of natural turbulent fluctuations of the incident flow. It has been found that the position of the second disk in the tandem affects the energy loss in the wake due to its expansion but does not influence the decay. The revealed patterns in the wake development...

  17. Tandem solar cells made from amorphous silicon and polymer bulk heterojunction sub-cells.

    Science.gov (United States)

    Park, Sung Heum; Shin, Insoo; Kim, Kwang Ho; Street, Robert; Roy, Anshuman; Heeger, Alan J

    2015-01-14

    A tandem solar cell based on a combination of an amorphous silicon (a-Si) and polymer solar cell (PSC) is demonstrated. As these tandem devices can be readily fabricated by low-cost methods, they require only a minor increase in the total manufacturing cost. Therefore, a combination of a-Si and PSC provides a compelling solution to reduce the cost of electricity produced by photovoltaics.

  18. Nonfullerene Tandem Organic Solar Cells with High Open-Circuit Voltage of 1.97 V.

    Science.gov (United States)

    Liu, Wenqing; Li, Shuixing; Huang, Jiang; Yang, Shida; Chen, Jiehuan; Zuo, Lijian; Shi, Minmin; Zhan, Xiaowei; Li, Chang-Zhi; Chen, Hongzheng

    2016-11-01

    Small-molecule nonfullerene-based tandem organic solar cells (OSCs) are fabricated for the first time by utilizing P3HT:SF(DPPB)4 and PTB7-Th:IEIC bulk heterojunctions as the front and back subcells, respectively. A power conversion efficiency of 8.48% is achieved with an ultrahigh open-circuit voltage of 1.97 V, which is the highest voltage value reported to date among efficient tandem OSCs.

  19. Bifacial Si Heterojunction-Perovskite Organic-Inorganic Tandem to Produce Highly Efficient Solar Cell

    OpenAIRE

    Asadpour, Reza; Chavali, Raghu V. K.; Khan, M. Ryyan; Alam, Muhammad A.

    2015-01-01

    As single junction thin-film technologies, both Si heterojunction (HIT) and Perovskite based solar cells promise high efficiencies at low cost. One expects that a tandem cell design with these cells connected in series will improve the efficiency further. Using a self-consistent numerical modeling of optical and transport characteristics, however, we find that a traditional series connected tandem design suffers from low Jsc due to band-gap mismatch and current matching constraints. It requir...

  20. Efficient inverted tandem polymer solar cells with a solution-processed recombination layer

    Energy Technology Data Exchange (ETDEWEB)

    Kouijzer, Sandra; Esiner, Serkan; Frijters, Corne H.; Wienk, Martijn M.; Janssen, Rene A.J. [Molecular Materials and Nanosystems, Eindhoven University of Technology (Netherlands); Turbiez, Mathieu [BASF Schweiz AG, Basel (Switzerland)

    2012-08-15

    Solution-processed tandem polymer solar cells with an inverted polarity configuration provide a power conversion efficiency of 5.8%. The tandem cells use an almost loss-free recombination layer and two photoactive layers, with wide and small bandgaps, to increase the power conversion efficiency beyond that of the corresponding single-layer cells. (Copyright copyright 2012 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  1. Tandem polymer solar cells: simulation and optimization through a multiscale scheme

    Directory of Open Access Journals (Sweden)

    Fanan Wei

    2017-01-01

    Full Text Available In this paper, polymer solar cells with a tandem structure were investigated and optimized using a multiscale simulation scheme. In the proposed multiscale simulation, multiple aspects – optical calculation, mesoscale simulation, device scale simulation and optimal power conversion efficiency searching modules – were studied together to give an optimal result. Through the simulation work, dependencies of device performance on the tandem structures were clarified by tuning the thickness, donor/acceptor weight ratio as well as the donor–acceptor distribution in both active layers of the two sub-cells. Finally, employing searching algorithms, we optimized the power conversion efficiency of the tandem polymer solar cells and located the optimal device structure parameters. With the proposed multiscale simulation strategy, poly(3-hexylthiophene/phenyl-C61-butyric acid methyl ester and (poly[2,6-(4,4-bis-(2-ethylhexyl-4H-cyclopenta[2,1-b;3,4-b]dithiophene-alt-4,7-(2,1,3-benzothiadiazole]/phenyl-C61-butyric acid methyl ester based tandem solar cells were simulated and optimized as an example. Two configurations with different sub-cell sequences in the tandem photovoltaic device were tested and compared. The comparison of the simulation results between the two configurations demonstrated that the balance between the two sub-cells is of critical importance for tandem organic photovoltaics to achieve high performance. Consistency between the optimization results and the reported experimental results proved the effectiveness of the proposed simulation scheme.

  2. Classroom tandem – Outlining a Model for Language Learning and Instruction

    Directory of Open Access Journals (Sweden)

    Katri KARJALAINEN

    2013-10-01

    Full Text Available The aim of this paper is to outline classroom tandem by comparing it with informal tandem learning contexts and other language instruction methods. Classroom tandem is used for second language instruction in mixed language groups in the subjects of Finnish and Swedish as L2. Tandem learning entails that two persons with different mother tongues learn each other’s native languages in reciprocal cooperation. The students function, in turns, as a second language learner and as a model in the native language. We aim to give an overview description of the interaction in classroom tandem practice. The empirical data consists of longitudinal video recordings of meetings of one tandem dyad within a co-located Swedish-medium and Finnish-medium school. Focus in the analysis is on the language aspects the informants orient to and topicalize in their interaction. The language aspects vary depending on what classroom activities they are engaged in, text-based or oral activities.

  3. Tandem polymer solar cells: simulation and optimization through a multiscale scheme.

    Science.gov (United States)

    Wei, Fanan; Yao, Ligang; Lan, Fei; Li, Guangyong; Liu, Lianqing

    2017-01-01

    In this paper, polymer solar cells with a tandem structure were investigated and optimized using a multiscale simulation scheme. In the proposed multiscale simulation, multiple aspects - optical calculation, mesoscale simulation, device scale simulation and optimal power conversion efficiency searching modules - were studied together to give an optimal result. Through the simulation work, dependencies of device performance on the tandem structures were clarified by tuning the thickness, donor/acceptor weight ratio as well as the donor-acceptor distribution in both active layers of the two sub-cells. Finally, employing searching algorithms, we optimized the power conversion efficiency of the tandem polymer solar cells and located the optimal device structure parameters. With the proposed multiscale simulation strategy, poly(3-hexylthiophene)/phenyl-C61-butyric acid methyl ester and (poly[2,6-(4,4-bis-(2-ethylhexyl)-4H-cyclopenta[2,1-b;3,4-b]dithiophene)-alt-4,7-(2,1,3-benzothiadiazole)])/phenyl-C61-butyric acid methyl ester based tandem solar cells were simulated and optimized as an example. Two configurations with different sub-cell sequences in the tandem photovoltaic device were tested and compared. The comparison of the simulation results between the two configurations demonstrated that the balance between the two sub-cells is of critical importance for tandem organic photovoltaics to achieve high performance. Consistency between the optimization results and the reported experimental results proved the effectiveness of the proposed simulation scheme.

  4. Numerical analysis of the s1020 airfoils in tandem under different flapping configurations

    Science.gov (United States)

    Lim, K. B.; Tay, W. B.

    2010-05-01

    The objective of this project is to improve the performance of the efficiency, thrust and lift of flapping wings in tandem arrangement. This research investigates the effect of the arrangement of the airfoils in tandem on the performance of the airfoils by varying the phase difference and distance between the airfoils. Three flapping configurations from an earlier phase of a research which gives high efficiency, thrust and lift are used in the tandem simulation. It is found all the different flapping configurations show improvement in the efficiency, thrust or lift when the distance between the two airfoils and the phase angle between the heaving positions of the two airfoils are optimal. The average thrust coefficient of the tandem arrangement managed to attain more than twice that of the single one (4.84 vs. 2.05). On the other hand, the average lift coefficient of the tandem arrangement also increased to 4.59, as compared to the original single airfoil value of 3.04. All these results obtained will aid in the design of a better ornithopter with tandem wing arrangement.

  5. Ligand binding by the tandem glycine riboswitch depends on aptamer dimerization but not double ligand occupancy.

    Science.gov (United States)

    Ruff, Karen M; Strobel, Scott A

    2014-11-01

    The glycine riboswitch predominantly exists as a tandem structure, with two adjacent, homologous ligand-binding domains (aptamers), followed by a single expression platform. The recent identification of a leader helix, the inclusion of which eliminates cooperativity between the aptamers, has reopened the debate over the purpose of the tandem structure of the glycine riboswitch. An equilibrium dialysis-based assay was combined with binding-site mutations to monitor glycine binding in each ligand-binding site independently to understand the role of each aptamer in glycine binding and riboswitch tertiary interactions. A series of mutations disrupting the dimer interface was used to probe how dimerization impacts ligand binding by the tandem glycine riboswitch. While the wild-type tandem riboswitch binds two glycine equivalents, one for each aptamer, both individual aptamers are capable of binding glycine when the other aptamer is unoccupied. Intriguingly, glycine binding by aptamer-1 is more sensitive to dimerization than glycine binding by aptamer-2 in the context of the tandem riboswitch. However, monomeric aptamer-2 shows dramatically weakened glycine-binding affinity. In addition, dimerization of the two aptamers in trans is dependent on glycine binding in at least one aptamer. We propose a revised model for tandem riboswitch function that is consistent with these results, wherein ligand binding in aptamer-1 is linked to aptamer dimerization and stabilizes the P1 stem of aptamer-2, which controls the expression platform.

  6. Matching of Silicon Thin-Film Tandem Solar Cells for Maximum Power Output

    Directory of Open Access Journals (Sweden)

    C. Ulbrich

    2013-01-01

    Full Text Available We present a meaningful characterization method for tandem solar cells. The experimental method allows for optimizing the output power instead of the current. Furthermore, it enables the extraction of the approximate AM1.5g efficiency when working with noncalibrated spectra. Current matching of tandem solar cells under short-circuit condition maximizes the output current but is disadvantageous for the overall fill factor and as a consequence does not imply an optimization of the output power of the device. We apply the matching condition to the maximum power output; that is, a stack of solar cells is power matched if the power output of each subcell is maximal at equal subcell currents. The new measurement procedure uses additional light-emitting diodes as bias light in the JV characterization of tandem solar cells. Using a characterized reference tandem solar cell, such as a hydrogenated amorphous/microcrystalline silicon tandem, it is possible to extract the AM1.5g efficiency from tandems of the same technology also under noncalibrated spectra.

  7. Tandem polymer solar cells: simulation and optimization through a multiscale scheme

    Science.gov (United States)

    Wei, Fanan; Yao, Ligang; Lan, Fei

    2017-01-01

    In this paper, polymer solar cells with a tandem structure were investigated and optimized using a multiscale simulation scheme. In the proposed multiscale simulation, multiple aspects – optical calculation, mesoscale simulation, device scale simulation and optimal power conversion efficiency searching modules – were studied together to give an optimal result. Through the simulation work, dependencies of device performance on the tandem structures were clarified by tuning the thickness, donor/acceptor weight ratio as well as the donor–acceptor distribution in both active layers of the two sub-cells. Finally, employing searching algorithms, we optimized the power conversion efficiency of the tandem polymer solar cells and located the optimal device structure parameters. With the proposed multiscale simulation strategy, poly(3-hexylthiophene)/phenyl-C61-butyric acid methyl ester and (poly[2,6-(4,4-bis-(2-ethylhexyl)-4H-cyclopenta[2,1-b;3,4-b]dithiophene)-alt-4,7-(2,1,3-benzothiadiazole)])/phenyl-C61-butyric acid methyl ester based tandem solar cells were simulated and optimized as an example. Two configurations with different sub-cell sequences in the tandem photovoltaic device were tested and compared. The comparison of the simulation results between the two configurations demonstrated that the balance between the two sub-cells is of critical importance for tandem organic photovoltaics to achieve high performance. Consistency between the optimization results and the reported experimental results proved the effectiveness of the proposed simulation scheme. PMID:28144571

  8. IMPACT OF SOME GEOMETRICAL ASPECTS ON THE TANDEM CO-ROTATING PROPELLER HYDRODYNAMIC CHARACTERISTICS

    Directory of Open Access Journals (Sweden)

    Boucetta Djahida

    2017-01-01

    Full Text Available In the present paper, a numerical simulation based on Kω-SST turbulence model has been carried out to determine the tandem propeller hydrodynamic characteristics in non-cavitating viscous flow by using the commercial code Fluent. As the first step, the numerical approach has been applied to the case of single propeller and the comparison with experiment results was in a good agreement. Next, the effects of axial and angular displacement as well as the diameter ratio between the tandem propellers have been investigated. This part of the study reveals that the tandem with idem propeller diameters is strongly recommended to assure more advantages. Furthermore, the tandem geometry corresponding to the axial displacement equal to 0.6D seems to be the best configuration and the open water performances remain almost unchanged with the variation of angular displacement. On the other hand, details of the mutual interaction between tandem propellers were also given by showing pressure contours, streamlines and thrust coefficient. Globally, this study illustrates the advantages of replacing single propellers by tandem solution.

  9. A Developed Methodology in Design of Highly Loaded Tandem Axial Flow Compressor Stage

    Directory of Open Access Journals (Sweden)

    Masoud Boroomand

    2016-01-01

    Full Text Available This study, primarily reports the development of a 3D design procedure for axial flow tandem compressor stages and then the method is used to design a highly loaded tandem stage. In order to investigate the effects of such arrangement, another stage with conventional loading with single blade for both rotor and stator rows is designed with similar specification. In order to ease the comparison of results, chord lengths and hub/shroud geometries are selected with the same dimensions. At the next stage a three dimensional numerical model is developed to predict the characteristic performance of both tandem and conventional stages. The model is validated with the experimental results of NASA-67 stage and the level of the accuracy of the model is presented. Employing the model to simulate the performance of both stages at design and offdesign operating points show that, tandem stage can provide higher pressure ratio with acceptable efficiency. In another word, tandem stage is capable having the same pressure ratio at lower rotational speed. The safe operation domain and loss mechanism in tandem stage are also discussed in this report.

  10. Dinuclear Tetrapyrazolyl Palladium Complexes Exhibiting Facile Tandem Transfer Hydrogenation/Suzuki Coupling Reaction of Fluoroarylketone

    KAUST Repository

    Dehury, Niranjan

    2016-07-18

    Herein, we report an unprecedented example of dinuclear pyrazolyl-based Pd complexes exhibiting facile tandem catalysis for fluoroarylketone: Tetrapyrazolyl di-palladium complexes with varying Pd-Pd distances efficiently catalyze the tandem reaction involving transfer hydrogenation of fluoroarylketone to the corresponding alcohol and Suzuki-Miyaura cross coupling reaction of the resulting fluoroarylalcohol under moderate reaction conditions, to biaryl alcohol. The complex with the shortest Pd-Pd distance exhibits the highest tandem activity among its di-metallic analogues, and exceeds in terms of activity and selectivity the analogous mononuclear compound. The kinetics of the reaction indicates clearly that reductive transformation of haloarylketone into haloaryalcohol is the rate determining step in the tandem reaction. Interestingly while fluoroarylketone undergoes the multistep tandem catalysis, the chloro- and bromo-arylketones undergo only a single step C-C coupling reaction resulting in biarylketone as the final product. Unlike the pyrazole based Pd compounds, the precursor PdCl2 and the phosphine based relevant complexes (PPh3)2PdCl2 and (PPh3)4Pd are found to be unable to exhibit the tandem catalysis.

  11. Silicon wafer-based tandem cells: The ultimate photovoltaic solution?

    Science.gov (United States)

    Green, Martin A.

    2014-03-01

    Recent large price reductions with wafer-based cells have increased the difficulty of dislodging silicon solar cell technology from its dominant market position. With market leaders expected to be manufacturing modules above 16% efficiency at 0.36/Watt by 2017, even the cost per unit area (60-70/m2) will be difficult for any thin-film photovoltaic technology to significantly undercut. This may make dislodgement likely only by appreciably higher energy conversion efficiency approaches. A silicon wafer-based cell able to capitalize on on-going cost reductions within the mainstream industry, but with an appreciably higher than present efficiency, might therefore provide the ultimate PV solution. With average selling prices of 156 mm quasi-square monocrystalline Si photovoltaic wafers recently approaching 1 (per wafer), wafers now provide clean, low cost templates for overgrowth of thin, wider bandgap high performance cells, nearly doubling silicon's ultimate efficiency potential. The range of possible Si-based tandem approaches is reviewed together with recent results and ultimate prospects.

  12. Tandem Differential Mobility Analyzer/Aerodynamic Particle Sizer (APS) Handbook

    Energy Technology Data Exchange (ETDEWEB)

    Collins, D

    2010-06-18

    The tandem differential mobility analyzer (TDMA) is a single instrument that cycles through a series of complementary measurements of the physical properties of size-resolved submicron particles. In 2008, the TDMA was augmented through the addition of an aerodynamic particle sizer (APS), which extends the upper limit of the measured size distribution into the supermicron range. These two instruments are operated in parallel, but because they are controlled by a common computer and because the size distributions measured by the two are integrated in the produced datastreams, they are described together here. Throughout the day, the TDMA sequentially measures submicron aerosol size distributions and size-resolved hygroscopic growth distributions. More specifically, the instrument is operated as a scanning DMA to measure size distributions and as a TDMA to measure size-resolved hygroscopicity. A typical measurement sequence requires roughly 45 minutes. Each morning additional measurements are made of the relative humidity (RH) dependent hygroscopicity and temperature-dependent volatility of size-resolved particles. When the outside temperature and RH are within acceptable ranges, the hydration state of size-resolved particles is also characterized. The measured aerosol distributions complement the array of aerosol instruments in the Aerosol Observing System (AOS) and provide additional details of the light-scattering and cloud-nucleating characteristics of the aerosol.

  13. Rapid comparison of diacetylmorphine on banknotes by tandem mass spectrometry.

    Science.gov (United States)

    Ebejer, Karl A; Brereton, Richard G; Carter, James F; Ollerton, Samantha L; Sleeman, Richard

    2005-01-01

    A procedure is described for the determination of the distribution of the contamination of banknotes with controlled drugs using tandem mass spectrometry. The method is illustrated using diacetylmorphine, which is the major active component of heroin. A series of banknotes is introduced into the mass spectrometer and the intensities of two product ions (m/z 328 and 268) derived from the precursor protonated molecule (m/z 370) are recorded. A banknote is considered contaminated if it shows a significant peak for both product ions, and if the ratio of intensities of these two peaks falls within accepted limits. The distribution of diacetylmorphine on sterling banknotes taken from general circulation within the UK can be modelled by an arcsin (square root) transformation of the data or by a log transformation of the data with a higher proportion of contamination. The two models were found to be in close agreement, predicting an upper limit (at 99.9% confidence) of contamination on banknotes from general circulation between 9 and 10%. The percentage contamination in a case study was calculated and compared to the background distribution using the two models proposed. This comparison revealed that the contamination present in the case study was inconsistent with that present on banknotes in general circulation. (c) 2005 John Wiley & Sons, Ltd.

  14. An evaluation of tandem mass spectrometry in drug metabolism studies.

    Science.gov (United States)

    Naylor, S; Kajbaf, M; Lamb, J H; Jahanshahi, M; Gorrod, J W

    1993-07-01

    The use of precursor ion and constant neutral loss scanning as a means of rapidly detecting drug metabolites is evaluated. Four clinically useful drugs, namely (i) cyclophosphamide, (ii) mifentidine, (iii) cimetropium bromide and (iv) haloperidol, were subjected to microsomal incubations to afford phase I metabolites. Aside from a minor clean-up procedure involving zinc sulfate precipitation of microsomal proteins and solid-phase extraction of metabolites using a Sep-pak C-18 cartridge, the mixtures were analysed directly by fast atom bombardment tandem mass spectrometry. It is demonstrated that such screening strategies are important in detecting novel metabolites. However, there are some problems associated with only using such methods, including (i) the possibility of not detecting metabolites that undergo unusual collision-induced dissociation fragmentation pathways, (ii) the non-detection of metabolites that have undergone metabolic change at unusual sites of reactivity, and (iii) production of artifacts derived from the parent drug by the primary ionization process. Examples are discussed that highlight both the strengths and weaknesses of such an approach.

  15. Fast atom bombardment tandem mass spectrometry of carotenoids

    Energy Technology Data Exchange (ETDEWEB)

    van Breeman, R.B. [Univ. of Illinois, Chicago, IL (United States); Schmitz, H.H.; Schwartz, S.J. [North Carolina State Univ., Raleigh, NC (United States)

    1995-02-01

    Positive ion fast atom bombardment (FAB) tandem mass spectrometry (MS-MS) using a double-focusing mass spectrometer with linked scanning at constant B/E and high-energy collisionally activated dissociation (CAD) was used to differentiate 17 different cartenoids, including {beta}-apo-8{prime}- carotenal, astaxanthin, {alpha}-carotene, {beta}-carotene, {gamma}-carotene, {zeta}-carotene, canthaxanthin, {beta}-cryptoxanthin, isozeaxanthin bis (pelargonate), neoxanthin, neurosporene, nonaprene, lutein, lycopene, phytoene, phytofluene, and zeaxanthin. The carotenoids were either synthetic or isolated from plant tissues. The use of FAB ionization minimized degradation or rearrangement of the carotenoid structures due to the inherent thermal instability generally ascribed to these compounds. Instead of protonated molecules, both polar xanthophylls and nonpolar carotenes formed molecular ions, M{sup {center_dot}+}, during FAB ionization. Following collisionally activated dissociation, fragment ions of selected molecular ion precursors showed structural features indicative of the presence of hydroxyl groups, ring systems, ester groups, and aldehyde groups and the extent of aliphatic polyene conjugation. The fragmentation patterns observed in the mass spectra herein may be used as a reference for the structural determination of carotenoids isolated from plant and animal tissues. 18 refs., 4 figs.

  16. Microchip-based forensic short tandem repeat genotyping.

    Science.gov (United States)

    Kim, Yong Tae; Heo, Hyun Young; Oh, Shin Hye; Lee, Seung Hwan; Kim, Do Hyun; Seo, Tae Seok

    2015-08-01

    Micro total analysis system (μTAS) or lab-on-a-chip (LOC) technology has advanced over decades, and the high performance for chemical and biological analysis has been well demonstrated with advantages of low sample consumption, rapid analysis time, high-throughput screening, and portability. In particular, μTAS or LOC based genetic applications have been extensively explored, and the short tandem repeat (STR) typing on a chip has garnered attention in the forensic community due to its special use for human identification in the field of mass disaster and missing person investigation, paternity testing, and perpetrator identification. The STR typing process consists of sample collection, DNA extraction, DNA quantitation, STR loci amplification, capillary electrophoretic separation, and STR profiling. Recent progress of microtechnology shows its ability to substitute the conventional analytical tools, and furthermore demonstrates total integration of the whole STR processes on a single wafer for on-site STR typing. In this review article, we highlighted some representative results for fluorescence labeling techniques, microchip-based DNA purification, on-chip polymerase chain reaction (PCR), a capillary electrophoretic microdevice, and a fully integrated microdevice for STR typing.

  17. The evolution and function of protein tandem repeats in plants.

    Science.gov (United States)

    Schaper, Elke; Anisimova, Maria

    2015-04-01

    Sequence tandem repeats (TRs) are abundant in proteomes across all domains of life. For plants, little is known about their distribution or contribution to protein function. We exhaustively annotated TRs and studied the evolution of TR unit variations for all Ensembl plants. Using phylogenetic patterns of TR units, we detected conserved TRs with unit number and order preserved during evolution, and those TRs that have diverged via recent TR unit gains/losses. We correlated the mode of evolution of TRs to protein function. TR number was strongly correlated with proteome size, with about one-half of all TRs recognized as common protein domains. The majority of TRs have been highly conserved over long evolutionary distances, some since the separation of red algae and green plants c. 1.6 billion yr ago. Conversely, recurrent recent TR unit mutations were rare. Our results suggest that the first TRs by far predate the first plants, and that TR appearance is an ongoing process with similar rates across the plant kingdom. Interestingly, the few detected highly mutable TRs might provide a source of variation for rapid adaptation. In particular, such TRs are enriched in leucine-rich repeats (LRRs) commonly found in R genes, where TR unit gain/loss may facilitate resistance to emerging pathogens.

  18. Systematic Profiling of Short Tandem Repeats in the Cattle Genome.

    Science.gov (United States)

    Xu, Lingyang; Haasl, Ryan J; Sun, Jiajie; Zhou, Yang; Bickhart, Derek M; Li, Junya; Song, Jiuzhou; Sonstegard, Tad S; Van Tassell, Curtis P; Lewin, Harris A; Liu, George E

    2017-01-01

    Short tandem repeats (STRs), or microsatellites, are genetic variants with repetitive 2–6 base pair motifs in many mammalian genomes. Using high-throughput sequencing and experimental validations, we systematically profiled STRs in five Holsteins. We identified a total of 60,106 microsatellites and generated the first high-resolution STR map, representing a substantial pool of polymorphism in dairy cattle. We observed significant STRs overlap with functional genes and quantitative trait loci (QTL). We performed evolutionary and population genetic analyses using over 20,000 common dinucleotide STRs. Besides corroborating the well-established positive correlation between allele size and variance in allele size, these analyses also identified dozens of outlier STRs based on two anomalous relationships that counter expected characteristics of neutral evolution. And one STR locus overlaps with a significant region of a summary statistic designed to detect STR-related selection. Additionally, our results showed that only 57.1% of STRs located within SNP-based linkage disequilibrium (LD) blocks whereas the other 42.9% were out of blocks. Therefore, a substantial number of STRs are not tagged by SNPs in the cattle genome, likely due to STR's distinct mutation mechanism and elevated polymorphism. This study provides the foundation for future STR-based studies of cattle genome evolution and selection.

  19. Tandem "click" reactions at acetylene-terminated Si(100) monolayers.

    Science.gov (United States)

    Ciampi, Simone; James, Michael; Michaels, Pauline; Gooding, J Justin

    2011-06-07

    We demonstrate a simple method for coupling alkynes to alkynes. The method involves tandem azide-alkyne cycloaddition reactions ("click" chemistry) for the immobilization of 1-alkyne species onto an alkyne modified surface in a one-pot procedure. In the case presented, these reactions take place on a nonoxidized Si(100) surface although the approach is general for linking alkynes to alkynes. The applicability of the method in the preparation of electrically well-behaved functionalized surfaces is demonstrated by coupling an alkyne-tagged ferrocene species onto alkyne-terminated Si(100) surfaces. The utility of the approach in biotechnology is shown by constructing a DNA sensing interface by derivatization of the acetylenyl surface with commercially available alkyne-tagged oligonucleotides. Cyclic voltametry, electrochemical impedance spectroscopy, X-ray photoelectron spectroscopy, and X-ray reflectometry are used to characterize the coupling reactions and performance of the final modified surfaces. These data show that this synthetic protocol gives chemically well-defined, electronically well-behaved, and robust (bio)functionalized monolayers on silicon semiconducting surfaces.

  20. Three-Dimensional Computations of Multiple Tandem Jets in Crossflow

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    The mixing and merging characteristics of multiple tandem jets in crossflow are investigated by use of the Computational Fluid Dynamics (CFD) code FLUENT. The realizable k~ε model is employed for turbulent closure of the Reynolds-averaged Navier-Stokes equations. Numerical experiments are performed for 1-, 2- and 4-jet groups, for jet-to-crossflow velocity ratios of R=4.2~16.3. The computed velocity and scalar concentration field are in good agreement with experiments using Particle Image Velocimetry (PIV) and Laser Induced Fluorescence (LIF), as well as previous work. The results show that the leading jet behavior is similar to a single free jet in crossflow, while all the downstream rear jets have less bent-over jet trajectories-suggesting a reduced ambient velocity for the rear jets. The concentration decay of the leading jet is greater than that of the rear jets. When normalized by appropriate crossflow momentum length scales, all jet trajectories follow a universal relation regardless of the sequential order of jet position and the number of jets. Supported by the velocity and trajectory measurements, the averaged maximum effective crossflow velocity ratio is computed to be in the range of 0.39 to 0.47.

  1. Improvement on Conventional Load Distribution Algorithm in Hot Tandem Mills

    Institute of Scientific and Technical Information of China (English)

    LI Hai-jun; XU Jian-zhong; WANG Guo-dong; LIU Xiang-hua

    2007-01-01

    Load distribution is a key technology in strip hot rolling process, which influences the coil′s microstructure and performance. Currently, Newton-Raphson algorithm is applied to load distribution of hot tandem mills in many hot rolling plants and has some serious defects such as having a strict restriction on initial iterative calculation value and requiring coefficient matrix of nonlinear equations to be nonsingular. To eliminate these defects and improve the online performance of the process control computer, Newton descendent numeric algorithm is introduced to this field to widen the initial value range and a new model named error conversion algorithm is put forth to deal with special conditions when the coefficient matrix is singular. Furthermore, considering the characteristics of load distribution, a condition of strip thickness distribution abnormality and corresponding solutions are provided which ensure that rolling parameters can be calculated normally. Simulation results show that the improved algorithm has overcome the defects of the Newton-Raphson algorithm and is suitable for online application.

  2. Tandem ion mobility spectrometry coupled to laser excitation.

    Science.gov (United States)

    Simon, Anne-Laure; Chirot, Fabien; Choi, Chang Min; Clavier, Christian; Barbaire, Marc; Maurelli, Jacques; Dagany, Xavier; MacAleese, Luke; Dugourd, Philippe

    2015-09-01

    This manuscript describes a new experimental setup that allows to perform tandem ion mobility spectrometry (IMS) measurements and which is coupled to a high resolution time-of-flight mass spectrometer. It consists of two 79 cm long drift tubes connected by a dual ion funnel assembly. The setup was built to permit laser irradiation of the ions in the transfer region between the two drift tubes. This geometry allows selecting ions according to their ion mobility in the first drift tube, to irradiate selected ions, and examine the ion mobility of the product ions in the second drift tube. Activation by collision is possible in the same region (between the two tubes) and between the second tube and the time-of-flight. IMS-IMS experiments on Ubiquitin are reported. We selected a given isomer of charge state +7 and explored its structural rearrangement following collisional activation between the two drift tubes. An example of IMS-laser-IMS experiment is reported on eosin Y, where laser irradiation was used to produce radical ions by electron photodetachment starting from doubly deprotonated species. This allowed measuring the collision cross section of the radical photo-product, which cannot be directly produced with an electrospray source.

  3. LLNL Tandem Mirror Experiment (TMX) upgrade vacuum system

    Energy Technology Data Exchange (ETDEWEB)

    Pickles, W.L.; Chargin, A.K.; Drake, R.P.

    1981-09-15

    TMX Upgrade is a large, tandem, magnetic-mirror fusion experiment with stringent requirements on base pressure (10/sup -8/ torr), low H reflux from the first walls, and peak gas pressure (5 x 10/sup -7/ torr) due to neutral beam gas during plasma operation. The 225 m/sup 3/ vacuum vessel is initially evacuated by turbopumps. Cryopumps provide a continuous sink for gases other than helium, deuterium, and hydrogen. The neutral beam system introduces up to 480 l/s of H or D. The hydrogen isotopes are pumped at very high speed by titanium sublimed onto two cylindrical radially separated stainless steel quilted liners with a total surface area of 540 m/sup 2/. These surfaces (when cooled to about 80/sup 0/K) provide a pumping speed of 6 x 10/sup 7/ l/s for hydrogen. The titanium getter system is programmable and is used for heating as well as gettering. The inner plasma liner can be operated at elevated temperatures to enhance migration of gases away from the surfaces close to the plasma. Glow discharge cleaning is part of the pumpdown procedure. The design features are discussed in conjunction with the operating procedures developed to manage the dynamic vacuum conditions.

  4. Poiseuille flow-induced vibrations of two cylinders in tandem

    Science.gov (United States)

    Lin, Jianzhong; Jiang, Renjie; Chen, Zhongli; Ku, Xiaoke

    2013-07-01

    Laminar flows past two tandem cylinders which are free to move transversely in a parallel-wall channel were studied numerically by the lattice Boltzmann method. With fixed Reynolds number Re=100, blockage ratio β=1/4 and structural damping ξ=0, the effect of streamwise separation between two cylinders at a range of S/D=[1.1, 10] on the motions of cylinders and fluids was studied for both mass ratios of m(*)=1 and m(*)=0.1. A variety of distinct vibration regimes involving periodic, quasi-periodic and non-periodic vibrations with corresponding flow patterns were observed. A detailed analysis of the vibration amplitudes, vibration frequencies and relative equilibrium positions for both mass ratios demonstrated that as S/D increases, the interaction of the two cylinders first enhances and then reduces. In the strong coupling regime, both cylinders oscillate periodically around the centerline of the channel with large vibration amplitudes and high vibration frequencies. By comparing with the case of an isolated cylinder, a further study indicated that the gap flow plays an important role in such a dynamic system, and the vortex cores formation behind the front cylinder causes the interaction of the cylinders decouple rapidly. Based on the present observations, such a dynamic model system can be considered as a novel type of vortex-induced vibrations (VIV) and is expected to find applications in fluid mixing and heat transfer.

  5. Regimes of flow induced vibration for tandem, tethered cylinders

    Science.gov (United States)

    Nave, Gary; Stremler, Mark

    2015-11-01

    In the wake of a bluff body, there are a number of dynamic response regimes that exist for a trailing bluff body depending on spacing, structural restoring forces, and the mass-damping parameter m* ζ . For tandem cylinders with low values of m* ζ , two such regimes of motion are Gap Flow Switching and Wake Induced Vibration. In this study, we consider the dynamics of a single degree-of-freedom rigid cylinder in the wake of another in these regimes for a variety of center-to-center cylinder spacings (3-5 diameters) and Reynolds numbers (4,000-11,000). The system consists of a trailing cylinder constrained to a circular arc around a fixed leading cylinder, which, for small angle displacements, bears a close resemblance to the transversely oscillating cylinders found more commonly in existing literature. From experiments on this system, we compare and contrast the dynamic response within these two regimes. Our results show sustained oscillations in the absence of a structural restoring force in all cases, providing experimental support for the wake stiffness assumption, which is based on the mean lift toward the center line of flow.

  6. Absorbed dose determination in photon fields using the tandem method

    CERN Document Server

    Marques-Pachas, J F

    1999-01-01

    The purpose of this work is to develop an alternative method to determine the absorbed dose and effective energy of photons with unknown spectral distributions. It includes a 'tandem' system that consists of two thermoluminescent dosemeters with different energetic dependence. LiF: Mg, Ti, CaF sub 2 : Dy thermoluminescent dosemeters and a Harshaw 3500 reading system are employed. Dosemeters are characterized with sup 9 sup 0 Sr- sup 9 sup 0 Y, calibrated with the energy of sup 6 sup 0 Co and irradiated with seven different qualities of x-ray beams, suggested by ANSI No. 13 and ISO 4037. The answers of each type of dosemeter are adjusted to a function that depends on the effective energy of photons. The adjustment is carried out by means of the Rosenbrock minimization algorithm. The mathematical model used for this function includes five parameters and has a gauss and a straight line. Results show that the analytical functions reproduce the experimental data of the answers, with a margin of error of less than ...

  7. Code domains in tandem repetitive DNA sequence structures.

    Science.gov (United States)

    Vogt, P

    1992-10-01

    Traditionally, many people doing research in molecular biology attribute coding properties to a given DNA sequence if this sequence contains an open reading frame for translation into a sequence of amino acids. This protein coding capability of DNA was detected about 30 years ago. The underlying genetic code is highly conserved and present in every biological species studied so far. Today, it is obvious that DNA has a much larger coding potential for other important tasks. Apart from coding for specific RNA molecules such as rRNA, snRNA and tRNA molecules, specific structural and sequence patterns of the DNA chain itself express distinct codes for the regulation and expression of its genetic activity. A chromatin code has been defined for phasing of the histone-octamer protein complex in the nucleosome. A translation frame code has been shown to exist that determines correct triplet counting at the ribosome during protein synthesis. A loop code seems to organize the single stranded interaction of the nascent RNA chain with proteins during the splicing process, and a splicing code phases successive 5' and 3' splicing sites. Most of these DNA codes are not exclusively based on the primary DNA sequence itself, but also seem to include specific features of the corresponding higher order structures. Based on the view that these various DNA codes are genetically instructive for specific molecular interactions or processes, important in the nucleus during interphase and during cell division, the coding capability of tandem repetitive DNA sequences has recently been reconsidered.

  8. Identification of polymorphic tandem repeats by direct comparison of genome sequence from different bacterial strains : a web-based resource

    Directory of Open Access Journals (Sweden)

    Vergnaud Gilles

    2004-01-01

    Full Text Available Abstract Background Polymorphic tandem repeat typing is a new generic technology which has been proved to be very efficient for bacterial pathogens such as B. anthracis, M. tuberculosis, P. aeruginosa, L. pneumophila, Y. pestis. The previously developed tandem repeats database takes advantage of the release of genome sequence data for a growing number of bacteria to facilitate the identification of tandem repeats. The development of an assay then requires the evaluation of tandem repeat polymorphism on well-selected sets of isolates. In the case of major human pathogens, such as S. aureus, more than one strain is being sequenced, so that tandem repeats most likely to be polymorphic can now be selected in silico based on genome sequence comparison. Results In addition to the previously described general Tandem Repeats Database, we have developed a tool to automatically identify tandem repeats of a different length in the genome sequence of two (or more closely related bacterial strains. Genome comparisons are pre-computed. The results of the comparisons are parsed in a database, which can be conveniently queried over the internet according to criteria of practical value, including repeat unit length, predicted size difference, etc. Comparisons are available for 16 bacterial species, and the orthopox viruses, including the variola virus and three of its close neighbors. Conclusions We are presenting an internet-based resource to help develop and perform tandem repeats based bacterial strain typing. The tools accessible at http://minisatellites.u-psud.fr now comprise four parts. The Tandem Repeats Database enables the identification of tandem repeats across entire genomes. The Strain Comparison Page identifies tandem repeats differing between different genome sequences from the same species. The "Blast in the Tandem Repeats Database" facilitates the search for a known tandem repeat and the prediction of amplification product sizes. The "Bacterial

  9. Simulation of tandem hydrofoils by finite volume method with moving grid system; Henkei koshi wo tsukatta yugen taisekiho ni yoru tandem suichuyoku no simulation

    Energy Technology Data Exchange (ETDEWEB)

    Kawashima, H. [Ship Research Inst., Tokyo (Japan); Miyata, H. [The University of Tokyo, Tokyo (Japan). Faculty of Engineering

    1996-12-31

    With an objective to clarify possibility of application of time-advancing calculated fluid dynamic (CFD) simulation by using a finite volume method with moving grid system, a simulation was performed on motion of a ship with hydrofoils including the control system therein. The simulation consists of a method that couples a moving grid system technology, an equation of motion, and the control system. Complex interactions between wings and with free surface may be considered automatically by directly deriving fluid force from a flow field by using the CFD. In addition, two-dimensional flows around tandem hydrofoils were calculated to solve the motion problem within a vertical plane. As a result, the following results were obtained: a finite volume method using a dynamic moving grid system method was applied to problems in non-steady tandem hydrofoils to show its usefulness; a method that couples the CFD with the equation of motion was applied to the control problems in the tandem hydrofoils to show possibility of a new technology for simulating motions; and a simulation that considers such wing interference as wave creation, discharged vortices, and associated flows was shown useful to understand characteristics of the tandem hydrofoils. 13 refs., 14 figs.

  10. Experimental studies on performance of tandem hydrofoils in high speed regions; Kosokuiki ni okeru tandem suichuyoku no seino ni kansuru jikkenteki kenkyu

    Energy Technology Data Exchange (ETDEWEB)

    Nakatake, K.; Oda, K.; Kataoka, K. [Kyushu University, Fukuoka (Japan). Faculty of Engineering; Okada, S. [Mitsubishi Heavy Industries, Ltd., Tokyo (Japan); Mizuno, S. [Hitachi Zosen Corp., Osaka (Japan)

    1996-10-01

    With an objective to clarify basic performance of hydrofoils, a towing experiment was carried out on single hydrofoil and tandem hydrofoils, whose results are reported in this paper. In the experiment, the tandem hydrofoils are supported on two stays on the left and right sides, and the whole lifting power and the whole drag including those of the stays were measured by using strain gauges placed on four plate springs. Results of the experiment may be summarized as follows: in the case of the single hydrofoil, the lifting power constant varied as a result of strong impact on free surface as the shallower the hydrofoil, but corresponds to the size of the lifting power coefficient in high speed regions; in the case of the tandem hydrofoils, the smaller the submersion depth, the effects grew larger on the lifting power coefficient and the drag coefficient, similarly to the case of the single hydrofoil; and the lifting power coefficient for the leading hydrofoils changes very little as a result of change in horizontal distance between the tandem hydrofoils, but the lifting power coefficient of the rear hydrofoils vibrates due to influence from the leading hydrofoils, with the peak of the value thereof transferring to the higher speed side as the horizontal distance increases. 3 refs., 10 figs., 2 tabs.

  11. Modeling the Performance Limitations and Prospects of Perovskite/Si Tandem Solar Cells under Realistic Operating Conditions.

    Science.gov (United States)

    Futscher, Moritz H; Ehrler, Bruno

    2017-09-08

    Perovskite/Si tandem solar cells have the potential to considerably out-perform conventional solar cells. Under standard test conditions, perovskite/Si tandem solar cells already outperform the Si single junction. Under realistic conditions, however, as we show, tandem solar cells made from current record cells are hardly more efficient than the Si cell alone. We model the performance of realistic perovskite/Si tandem solar cells under real-world climate conditions, by incorporating parasitic cell resistances, nonradiative recombination, and optical losses into the detailed-balance limit. We show quantitatively that when optimizing these parameters in the perovskite top cell, perovskite/Si tandem solar cells could reach efficiencies above 38% under realistic conditions, even while leaving the Si cell untouched. Despite the rapid efficiency increase of perovskite solar cells, our results emphasize the need for further material development, careful device design, and light management strategies, all necessary for highly efficient perovskite/Si tandem solar cells.

  12. Familial Lymphoproliferative Malignancies and Tandem Duplication of NF1 Gene

    Directory of Open Access Journals (Sweden)

    Gustavo Fernandes

    2014-01-01

    Full Text Available Background. Neurofibromatosis type 1 is a genetic disorder caused by loss-of-function mutations in a tumor suppressor gene (NF1 which codifies the protein neurofibromin. The frequent genetic alterations that modify neurofibromin function are deletions and insertions. Duplications are rare and phenotype in patients bearing duplication of NF1 gene is thought to be restricted to developmental abnormalities, with no reference to cancer susceptibility in these patients. We evaluated a patient who presented with few clinical signs of neurofibromatosis type 1 and a conspicuous personal and familiar history of different types of cancer, especially lymphoproliferative malignancies. The coding region of the NF-1 gene was analyzed by real-time polymerase chain reaction and direct sequencing. Multiplex ligation-dependent probe amplification was performed to detect the number of mutant copies. The NF1 gene analysis showed the following alterations: mosaic duplication of NF1, TRAF4, and MYO1D. Fluorescence in situ hybridization using probes (RP5-1002G3 and RP5-92689 flanking NF1 gene in 17q11.2 and CEP17 for 17q11.11.1 was performed. There were three signals (RP5-1002G3conRP5-92689 in the interphases analyzed and two signals (RP5-1002G3conRP5-92689 in 93% of cells. These findings show a tandem duplication of 17q11.2. Conclusion. The case suggests the possibility that NF1 gene duplication may be associated with a phenotype characterized by lymphoproliferative disorders.

  13. TANDEM COMPRESSION OF MEDULLA SPINALIS AND CAUDA AEQUINA

    Directory of Open Access Journals (Sweden)

    Zhelyazkov Christo

    2015-03-01

    Full Text Available Objective: To analyze and present cases of tandem compression of medulla spinalis and cauda equina. Material and Methods: The subjects of observation were four patients with simultaneous compression of medulla spinalis and cauda equina, admitted to the Neurosurgery Clinic of the St George University Hospital, Plovdiv, Bulgaria during the period March 2012 — March 2014. The average age of the patients was 60.5 years (47–72. In one case, left-sided paramedian herniated discs were found at levels L1–2 and L4–5 combined with a concomitant stenosis, in another case — right-sided paramedian herniated discs on the level of Th12 — L1 and a degenerative stenosis at level of L3–4, in the third case — pronounced degenerative compression at level Th7–8 and a central stenosis at level of L4–5, and in the last case — degenerative stenosis at level L3–5 and spinal meningioma at level Th9–10. Results: The clinical signs of the simultaneous compression of the spinal cord and cauda equina have been examined. These signs may mislead the physician in the diagnosis of the spinal lesion, thus, resulting in inappropriate surgical strategy. Conclusion: The involvement of the spinal cord must be clinically confirmed to rule out lesions in the thoracic region. When the lumbar imaging examinations are inconclusive or cannot explain the clinical symptoms of a certain patient, it is advisable to perform a magnetic resonance imaging of the entire spin

  14. Flow and noise predictions for the tandem cylinder aeroacoustic benchmarka)

    Science.gov (United States)

    Brès, Guillaume A.; Freed, David; Wessels, Michael; Noelting, Swen; Pérot, Franck

    2012-03-01

    Flow and noise predictions for the tandem cylinder benchmark are performed using lattice Boltzmann and Ffowcs Williams-Hawkings methods. The numerical results are compared to experimental measurements from the Basic Aerodynamic Research Tunnel and Quiet Flow Facility (QFF) at NASA Langley Research Center. The present study focuses on two configurations: the first configuration corresponds to the typical setup with uniform inflow and spanwise periodic boundary condition. To investigate installation effects, the second configuration matches the QFF setup and geometry, including the rectangular open jet nozzle, and the two vertical side plates mounted in the span to support the test models. For both simulations, the full span of 16 cylinder diameters is simulated, matching the experimental dimensions. Overall, good agreement is obtained with the experimental surface data, flow field, and radiated noise measurements. In particular, the presence of the side plates significantly reduces the excessive spanwise coherence observed with periodic boundary conditions and improves the predictions of the tonal peak amplitude in the far-field noise spectra. Inclusion of the contributions from the side plates in the calculation of the radiated noise shows an overall increase in the predicted spectra and directivity, leading to a better match with the experimental measurements. The measured increase is about 1 to 2 dB at the main shedding frequency and harmonics, and is likely caused by reflections on the spanwise side plates. The broadband levels are also slightly higher by about 2 to 3 dB, likely due to the shear layers from the nozzle exit impacting the side plates.

  15. Preliminary design study of the Tandem Mirror Reactor (TMR)

    Energy Technology Data Exchange (ETDEWEB)

    Moir, R.W.; Barr, W.L.; Carlson, G.A.

    1978-07-15

    This report describes work done in Fiscal Year 1977 by the Fusion Reactor Studies Group of LLL on the conceptual design of a 1000-MW(e) Tandem Mirror Reactor (TMR). The high Q (defined as the ratio of fusion power to injection power) predicted for the TMR (approximately 5) reduces the recirculating power to a nondominant problem and results in an attractive mirror fusion power plant. The fusion plasma of the TMR is contained in the 100-m-long central cell where the magnetic field strength is a modest 2 T. The blanket for neutron energy recovery and tritium breeding is cylindrical and, along with the solenoidal magnet, is divided into 3-m-long modules to facilitate maintenance. The central cell is fueled (but not heated) by the injection of low-energy neutral beams near its ends. Thus, the central cell is simple and of low technology. The end-cell plasmas must be of high density and high energy in order to plug and heat (via the electrons) the central-cell plasma. The present conceptual design uses 1.2-MeV neutral-beam injection for the end plugs and a cryogenic-aluminum, Yin-Yang magnet that produces an incremental field of about 1 T over a field of 16 T produced by a pair of Nb/sub 3/Sn superconducting solenoids. Important design problems remain in both the neutral-beam injector and in the end-plug magnet. Also remaining are important physics questions such as alpha-beam particle transport and end-plug stability. These questions are discussed at length in the report and suggestions for future work are given.

  16. Revisiting hyper- and hypo-androgenism by tandem mass spectrometry.

    Science.gov (United States)

    Fanelli, Flaminia; Gambineri, Alessandra; Mezzullo, Marco; Vicennati, Valentina; Pelusi, Carla; Pasquali, Renato; Pagotto, Uberto

    2013-06-01

    Modern endocrinology is living a critical age of transition as far as laboratory testing and biochemical diagnosis are concerned. Novel liquid chromatography-tandem mass spectrometry (LC-MS/MS) assays for steroid measurement in biological fluids have abundantly demonstrated their analytical superiority over immunometric platforms that until now have dominated the world of steroid hormones determination in clinical laboratories. One of the most useful applications of LC-MS/MS is in the hypogonadism and hyperandrogenism field: LC-MS/MS has proved particularly suitable for the detection of low levels of testosterone typical of women and children, and in general more reliable in accurately determining hypogonadal male levels. This technique also offers increased informative power by allowing multi-analytical profiles that give a more comprehensive picture of the overall hormonal asset. Several LC-MS/MS methods for testosterone have been published in the last decade, some of them included other androgen or more comprehensive steroid profiles. LC-MS/MS offers the concrete possibility of achieving a definitive standardization of testosterone measurements and the generation of widely accepted reference intervals, that will set the basis for a consensus on the diagnostic value of biochemical testing. The present review is aimed at summarizing technological advancements in androgen measurements in serum and saliva. We also provide a picture of the state of advancement of standardization of testosterone assays, of the redefinition of androgen reference intervals by novel assays and of studies using LC-MS/MS for the characterization and diagnosis of female hyperandrogenism and male hypogonadism.

  17. Band gap engineering of tandem structured CIGS compound absorption layer fabricated by sputtering and selenization

    Energy Technology Data Exchange (ETDEWEB)

    Kang, San; Sharma, Rahul; Sim, Jae-Kwan [Semiconductor Materials Processing Laboratory, School of Advanced Materials Engineering, College of Engineering, Research Center for Advanced Materials Development (RCAMD), Chonbuk National University, Deokjin-dong 664-14, Jeonju 561-756 (Korea, Republic of); Lee, Cheul-Ro, E-mail: crlee7@jbnu.ac.kr [Semiconductor Materials Processing Laboratory, School of Advanced Materials Engineering, College of Engineering, Research Center for Advanced Materials Development (RCAMD), Chonbuk National University, Deokjin-dong 664-14, Jeonju 561-756 (Korea, Republic of)

    2013-06-25

    Highlights: ► Systematic band gap engineering to fabricate tandem Cu(In,Ga)Se{sub 2} absorption layers. ► XRD shows prominent (1 1 2) reflection shift for attributed CIS, CIGS, and CGS phases. ► Optical transmittance and reflectance spectrum are improved towards infrared region. ► The Cu/In + Ga and Ga/In + Ga effect is matched with highest efficient solar cell. ► Tandem CIS/CIGS/CGS layer, the band gap is increased from 1.15 to 2.06 eV. -- Abstract: Band gap engineering was executed to fabricate a multi-junction stacked i.e. tandem Cu(In,Ga)Se{sub 2} (CIGS) absorption layer. The CIGS absorption layers consist of multi-junction stacked CIS/CIGS/CGS thin films from bottom to top with increasing band gap. Tandem CIGS layers were fabricated by using three precursor of CuIn, In/CuGa/In, and CuGa onto the Mo coated soda-lime glass (SLG) by the sequential sputtering of CuIn, CuGa, and In targets. The CIG precursors were converted into CIGS absorption thin film by selenization process. From the X-ray diffraction (XRD) pattern of CIS/CIGS/CGS tandem layer, with the prominent peak shift for (1 1 2) reflections was attributed to the individual CIS, CIGS, and CGS phases at 26.76°, 27.15°, and 27.65° diffraction angles, respectively. The morphologies and atomic (at%) composition uniformity onto the surface and along the depth were extensively analyzed with field effect scanning electron microscope (FESEM) attached energy dispersive spectroscopy (EDS) and secondary ion mass spectroscopy (SIMS). The optical properties such as transmittance, reflectance and absorbance were found to improve in the infrared region for all the tandem CIGS layers. Near the fundamental absorption edge, the absorption coefficient was approached to 10{sup 5} cm{sup −1} for CIS/CIGS/CGS tandem layer. The straight-line behavior indicates that the films have a direct band gap. The band gap was found to increase from 1.15 to 1.74 eV with the Ga-grading along the depth of individual CIS, CIGS

  18. Controlled human malaria infection trials: How tandems of trust and control construct scientific knowledge.

    Science.gov (United States)

    Bijker, Else M; Sauerwein, Robert W; Bijker, Wiebe E

    2016-02-01

    Controlled human malaria infections are clinical trials in which healthy volunteers are deliberately infected with malaria under controlled conditions. Controlled human malaria infections are complex clinical trials: many different groups and institutions are involved, and several complex technologies are required to function together. This functioning together of technologies, people, and institutions is under special pressure because of potential risks to the volunteers. In this article, the authors use controlled human malaria infections as a strategic research site to study the use of control, the role of trust, and the interactions between trust and control in the construction of scientific knowledge. The authors argue that tandems of trust and control play a central role in the successful execution of clinical trials and the construction of scientific knowledge. More specifically, two aspects of tandems of trust and control will be highlighted: tandems are sites where trust and control coproduce each other, and tandems link the personal, the technical, and the institutional domains. Understanding tandems of trust and control results in setting some agendas for both clinical trial research and science and technology studies.

  19. Sequence-regulated copolymers via tandem catalysis of living radical polymerization and in situ transesterification.

    Science.gov (United States)

    Nakatani, Kazuhiro; Ogura, Yusuke; Koda, Yuta; Terashima, Takaya; Sawamoto, Mitsuo

    2012-03-07

    Sequence regulation of monomers is undoubtedly a challenging issue as an ultimate goal in polymer science. To efficiently produce sequence-controlled copolymers, we herein developed the versatile tandem catalysis, which concurrently and/or sequentially involved ruthenium-catalyzed living radical polymerization and in situ transesterification of methacrylates (monomers: RMA) with metal alkoxides (catalysts) and alcohols (ROH). Typically, gradient copolymers were directly obtained from the synchronization of the two reactions: the instantaneous monomer composition in feed gradually changed via the transesterification of R(1)MA into R(2)MA in the presence of R(2)OH during living polymerization to give R(1)MA/R(2)MA gradient copolymers. The gradient sequence of monomers along a chain was catalytically controlled by the reaction conditions such as temperature, concentration and/or species of catalysts, alcohols, and monomers. The sequence regulation of multimonomer units was also successfully achieved in one-pot by monomer-selective transesterification in concurrent tandem catalysis and iterative tandem catalysis, providing random-gradient copolymers and gradient-block counterparts, respectively. In contrast, sequential tandem catalysis via the variable initiation of either polymerization or in situ transesterification led to random or block copolymers. Due to the versatile adaptability of common and commercially available reagents (monomers, alcohols, catalysts), this tandem catalysis is one of the most efficient, convenient, and powerful tools to design tailor-made sequence-regulated copolymers.

  20. Organic-inorganic halide perovskite/crystalline silicon four-terminal tandem solar cells.

    Science.gov (United States)

    Löper, Philipp; Moon, Soo-Jin; de Nicolas, Sílvia Martín; Niesen, Bjoern; Ledinsky, Martin; Nicolay, Sylvain; Bailat, Julien; Yum, Jun-Ho; De Wolf, Stefaan; Ballif, Christophe

    2015-01-21

    Tandem solar cells constructed from a crystalline silicon (c-Si) bottom cell and a low-cost top cell offer a promising way to ensure long-term price reductions of photovoltaic modules. We present a four-terminal tandem solar cell consisting of a methyl ammonium lead triiodide (CH3NH3PbI3) top cell and a c-Si heterojunction bottom cell. The CH3NH3PbI3 top cell exhibits broad-band transparency owing to its design free of metallic components and yields a transmittance of >55% in the near-infrared spectral region. This allows the generation of a short-circuit current density of 13.7 mA cm(-2) in the bottom cell. The four-terminal tandem solar cell yields an efficiency of 13.4% (top cell: 6.2%, bottom cell: 7.2%), which is a gain of 1.8%abs with respect to the reference single-junction CH3NH3PbI3 solar cell with metal back contact. We employ the four-terminal tandem solar cell for a detailed investigation of the optical losses and to derive guidelines for further efficiency improvements. Based on a power loss analysis, we estimate that tandem efficiencies of ∼28% are attainable using an optically optimized system based on current technology, whereas a fully optimized, ultimate device with matched current could yield up to 31.6%.

  1. Ligand binding to WW tandem domains of YAP2 transcriptional regulator is under negative cooperativity.

    Science.gov (United States)

    Schuchardt, Brett J; Mikles, David C; Hoang, Lawrence M; Bhat, Vikas; McDonald, Caleb B; Sudol, Marius; Farooq, Amjad

    2014-12-01

    YES-associated protein 2 (YAP2) transcriptional regulator drives a multitude of cellular processes, including the newly discovered Hippo tumor suppressor pathway, by virtue of the ability of its WW domains to bind and recruit PPXY-containing ligands to specific subcellular compartments. Herein, we employ an array of biophysical tools to investigate allosteric communication between the WW tandem domains of YAP2. Our data show that the WW tandem domains of YAP2 negatively cooperate when binding to their cognate ligands. Moreover, the molecular origin of such negative cooperativity lies in an unfavorable entropic contribution to the overall free energy relative to ligand binding to isolated WW domains. Consistent with this notion, the WW tandem domains adopt a fixed spatial orientation such that the WW1 domain curves outwards and stacks onto the binding groove of the WW2 domain, thereby sterically hindering ligand binding to both itself and its tandem partner. Although ligand binding to both WW domains disrupts such interdomain stacking interaction, they reorient themselves and adopt an alternative fixed spatial orientation in the liganded state by virtue of their ability to engage laterally so as to allow their binding grooves to point outwards and away from each other. In short, while the ability of WW tandem domains to aid ligand binding is well documented, our demonstration that they may also be subject to negative binding cooperativity represents a paradigm shift in our understanding of the molecular action of this ubiquitous family of protein modules.

  2. Hybrid tandem quantum dot/organic photovoltaic cells with complementary near infrared absorption

    Science.gov (United States)

    Kim, Taesoo; Palmiano, Elenita; Liang, Ru-Ze; Hu, Hanlin; Murali, Banavoth; Kirmani, Ahmad R.; Firdaus, Yuliar; Gao, Yangqin; Sheikh, Arif; Yuan, Mingjian; Mohammed, Omar F.; Hoogland, Sjoerd; Beaujuge, Pierre M.; Sargent, Edward H.; Amassian, Aram

    2017-05-01

    Monolithically integrated hybrid tandem solar cells that effectively combine solution-processed colloidal quantum dot (CQD) and organic bulk heterojunction subcells to achieve tandem performance that surpasses the individual subcell efficiencies have not been demonstrated to date. In this work, we demonstrate hybrid tandem cells with a low bandgap PbS CQD subcell harvesting the visible and near-infrared photons and a polymer:fullerene—poly (diketopyrrolopyrrole-terthiophene) (PDPP3T):[6,6]-phenyl-C60-butyric acid methyl ester (PC61BM)—top cell absorbing effectively the red and near-infrared photons of the solar spectrum in a complementary fashion. The two subcells are connected in series via an interconnecting layer (ICL) composed of a metal oxide layer, a conjugated polyelectrolyte, and an ultrathin layer of Au. The ultrathin layer of Au forms nano-islands in the ICL, reducing the series resistance, increasing the shunt resistance, and enhancing the device fill-factor. The hybrid tandems reach a power conversion efficiency (PCE) of 7.9%, significantly higher than the PCE of the corresponding individual single cells, representing one of the highest efficiencies reported to date for hybrid tandem solar cells based on CQD and polymer subcells.

  3. Tandem organic light-emitting diode with a molybdenum tri-oxide thin film interconnector layer

    Institute of Scientific and Technical Information of China (English)

    Lu Fei-Ping; Wang Qian; Zhou Xiang

    2013-01-01

    A 10-nm-thick molybdenum tri-oxide (MoO3) thin film was used as the interconnector layer in tandem organic lightemitting devices (OLEDs).The tandem OLEDs with two identical emissive units consisting of N,N'-bis(naphthalen-1-yl)-N,N'-bis(phenyl)-benzidine (NPB) / tris(8-hydroxyquinoline) aluminum (Alq3) exhibited current efficiency-current density characteristics superior to the conventional single-unit devices.At 20 mA/cm2,the current efficiency of the tandem OLEDs using the interconnector layers of MoO3 thin film was about 4.0 cd/A,which is about twice that of the corresponding conventional single-unit device (1.8 cd/A).The tandem OLED showed a higher power efficiency than the conventional single-unit device for luminance over 1200 cd/m2.The experimental results demonstrated that a MoO3 thin film with a proper thickness can be used as an effective interconnector layer in tandem OLEDs.Such an interconnector layer can be easily fabricated by simple thermal evaporation,greatly simplifying the device processing and fabrication processes required by previously reported interconnector layers.A possible explanation was proposed for the carrier generation of the MoO3 interconnector layer.

  4. Ligand Binding to WW Tandem Domains of YAP2 Transcriptional Regulator Is Under Negative Cooperativity

    Science.gov (United States)

    Schuchardt, Brett J.; Mikles, David C.; Hoang, Lawrence M.; Bhat, Vikas; McDonald, Caleb B.; Sudol, Marius; Farooq, Amjad

    2014-01-01

    YAP2 transcriptional regulator drives a multitude of cellular processes, including the newly discovered Hippo tumor suppressor pathway, by virtue of the ability of its WW domains to bind and recruit PPXY-containing ligands to specific subcellular compartments. Herein, we employ an array of biophysical tools to investigate allosteric communication between the WW tandem domains of YAP2. Our data show that the WW tandem domains of YAP2 negatively cooperate when binding to their cognate ligands. Moreover, the molecular origin of such negative cooperativity lies in an unfavorable entropic contribution to the overall free energy relative to ligand binding to isolated WW domains. Consistent with this notion, the WW tandem domains adopt a fixed spatial orientation such that the WW1 domain curves outwards and stacks onto the binding groove of WW2 domain, thereby sterically hindering ligand binding to both itself and its tandem partner. Although ligand binding to both WW domains disrupts such interdomain stacking interaction, they reorient themselves and adopt an alternative fixed spatial orientation in the liganded state by virtue of their ability to engage laterally so as to allow their binding grooves to point outwards and away from each other. In short, while the ability of WW tandem domains to aid ligand binding is well-documented, our demonstration that they may also be subject to negative binding cooperativity represents a paradigm shift in our understanding of the molecular action of this ubiquitous family of protein modules. PMID:25283809

  5. Detailed balance analysis of area de-coupled double tandem photovoltaic modules

    Science.gov (United States)

    Strandberg, Rune

    2015-01-01

    This paper describes how layers of area de-coupled top and bottom cells in photovoltaic tandem modules can increase the efficiency of two-terminal tandem devices. The point of the area de-coupling is to allow the number of top cells to differ from the number of bottom cells. Within each of the layers, the cells can be horizontally series-connected and the layers can then be current- or voltage-matched with each other in a tandem module. Using detailed balance modeling, it is shown that two-terminal tandem modules of this type can achieve the same theoretical efficiency as stacks of independently operated cells, often referred to as four-terminal cells. Optimal ratios of the number of bottom cells to the number of top cells are calculated. Finally, it is shown that modules with a bottom layer consisting of 60 cells with a band gap of 1.11 eV, resembling standard silicon modules, offer sufficient resolution to optimize the number of top cells and achieve high efficiency over a large range of top cell band gaps. This result extends the list of materials that can be used as top cells in two-terminal tandem modules with silicon bottom cells.

  6. Tandem ring-opening/ring-closing metathesis polymerization: relationship between monomer structure and reactivity.

    Science.gov (United States)

    Park, Hyeon; Lee, Ho-Keun; Choi, Tae-Lim

    2013-07-24

    Monomers containing either cycloalkenes with low ring strain or 1-alkynes are poor monomers for olefin metathesis polymerization. Ironically, keeping two inactive functional groups in proximity within one molecule can make it an excellent monomer for metathesis polymerization. Recently, we demonstrated that monomer 1 having cyclohexene and propargyl moieties underwent rapid tandem ring-opening/ring-closing metathesis (RO/RCM) polymerization via relay-type mechanism. Furthermore, living polymerization was achieved when a third-generation Grubbs catalyst was used. Here, we present a full account on this tandem polymerization by investigating how various structural modifications of the monomers affected the reactivity of the tandem polymerization. We observed that changing the ring size of the cycloalkene moieties, the length of the alkynes, and linker units influenced not only the polymerization rates but also the reactivities of Diels-Alder reaction, which is a post-modification reaction of the resulting polymers. Also, the mechanism of tandem polymerization was studied by conducting end-group analysis using (1)H NMR analysis, thereby concluding that the polymerization occurred by the alkyne-first pathway. With this mechanistic conclusion, factors responsible for the dramatic structure-reactivity relationship were proposed. Lastly, tandem RO/RCM polymerization of monomers containing sterically challenging trisubstituted cycloalkenes was successfully carried out to give polymer repeat units having tetrasubstituted cycloalkenes.

  7. Hybrid tandem quantum dot/organic photovoltaic cells with complementary near infrared absorption

    KAUST Repository

    Kim, Taesoo

    2017-06-01

    Monolithically integrated hybrid tandem solar cells that effectively combine solution-processed colloidal quantum dot (CQD) and organic bulk heterojunction subcells to achieve tandem performance that surpasses the individual subcell efficiencies have not been demonstrated to date. In this work, we demonstrate hybrid tandem cells with a low bandgap PbS CQD subcell harvesting the visible and near-infrared photons and a polymer:fullerene—poly (diketopyrrolopyrrole-terthiophene) (PDPP3T):[6,6]-phenyl-C60-butyric acid methyl ester (PC61BM)—top cell absorbing effectively the red and near-infrared photons of the solar spectrum in a complementary fashion. The two subcells are connected in series via an interconnecting layer (ICL) composed of a metal oxide layer, a conjugated polyelectrolyte, and an ultrathin layer of Au. The ultrathin layer of Au forms nano-islands in the ICL, reducing the series resistance, increasing the shunt resistance, and enhancing the device fill-factor. The hybrid tandems reach a power conversion efficiency (PCE) of 7.9%, significantly higher than the PCE of the corresponding individual single cells, representing one of the highest efficiencies reported to date for hybrid tandem solar cells based on CQD and polymer subcells.

  8. Stacking multiple connecting functional materials in tandem organic light-emitting diodes

    Science.gov (United States)

    Zhang, Tao; Wang, Deng-Ke; Jiang, Nan; Lu, Zheng-Hong

    2017-01-01

    Tandem device is an important architecture in fabricating high performance organic light-emitting diodes and organic photovoltaic cells. The key element in making a high performance tandem device is the connecting materials stack, which plays an important role in electric field distribution, charge generation and charge injection. For a tandem organic light-emitting diode (OLED) with a simple Liq/Al/MoO3 stack, we discovered that there is a significant current lateral spreading causing light emission over an extremely large area outside the OLED pixel when the Al thickness exceeds 2 nm. This spread light emission, caused by an inductive electric field over one of the device unit, limits one’s ability to fabricate high performance tandem devices. To resolve this issue, a new connecting materials stack with a C60 fullerene buffer layer is reported. This new structure permits optimization of the Al metal layer in the connecting stack and thus enables us to fabricate an efficient tandem OLED having a high 155.6 cd/A current efficiency and a low roll-off (or droop) in current efficiency. PMID:28225028

  9. Identification and characterization of tandem repeats in exon III of dopamine receptor D4 (DRD4) genes from different mammalian species

    DEFF Research Database (Denmark)

    Larsen, Svend Arild; Mogensen, Line; Dietz, Rune

    2005-01-01

    tandem repeat, while a tandem repeat consisting of 27-bp modules was identified in a sequence from European badger. Both these tandem repeats were composed of 9-bp basic units, which were closely related with the 9-bp repeat modules identified in the mink and ferret. Tandem repeats could...... repeat being found. In the domestic cow and gray seal we identified tandem repeats composed of 36-bp modules, each consisting of two closely related 18-bp basic units. A tandem repeat consisting of 9-bp modules was identified in sequences from mink and ferret. In the European otter we detected an 18-bp...

  10. A instituição de ensino superior e a questão da baixa complexidade: um desafio ao desenvolvimento social baseado num olhar direcionado ao sistema de avaliação da qualidade na América Latina

    Directory of Open Access Journals (Sweden)

    Janete Rosa da Fonseca

    2014-11-01

    Full Text Available O presente estudo trata de uma análise crítica sobre o sistema de Avaliação da Qualidade do Ensino Superior no Brasil e em mais cinco países da América Latina, Argentina, Chile, Colômbia, Paraguai e Uruguai. No Brasil a análise se desenvolveu com IES representantes das cinco regiões. Definiu-se a abordagem partir da origem das primeiras instituições, a primeira universidade e a participação dos governos e da Igreja Católica na criação e expansão dessas instituições do medievo ao sonho Bolivariano. A pesquisa tem como objetivos analisar a questão da baixa complexidade em instituição de Ensino Superior diante do desafio ao desenvolvimento social baseado num olhar direcionado ao sistema de avaliação da qualidade na América Latina, através da percepção de administradores e docentes de diversos países sobre a Avaliação da qualidade. Conhecer as propostas de busca pela avaliação da qualidade no Ensino Superior que vem sendo discutidas nos países representativos da América Latina. Relacionar as percepções das IES participantes da amostra diante da legislação específica de cada país, identificando aspectos coerentes ou dificultadores para a satisfação, interesses e demandas dos atores educativos envolvidos; Comparar os critérios utilizados para autorização, reconhecimento e avaliação de Instituições de Ensino Superior diante das legislações previstas e efetivamente executadas; Apontar as deficiências do sistema de avaliação da qualidade utilizado pelos países integrantes dessa proposta de pesquisa, constituem-se nos objetivos desta pesquisa. Em um plano mais específico, há que se responder, por meio do estudo realizado, se a questão da baixa complexidade em instituição de ensino superior constitui-se num desafio ao desenvolvimento social baseado num olhar direcionado ao sistema de avaliação da qualidade na América Latina. Assim sendo, o estudo proposto tem como abordagem metodológica a

  11. The Brazilian hazard-based cut-off criteria for pesticide registration: a critical appraisal / Critérios de exclusão baseados em perigo adotados no Brasil para registro de pesticidas: Uma avalição crítica

    Directory of Open Access Journals (Sweden)

    Francisco José Roma Paumgartten

    2013-02-01

    Full Text Available Brazil, the world’s top consumer of agricultural pesticides, adopts a unique hazard-based cut-off approach to pesticide registration. Cut-off criteria for mutagenicity, carcinogenicity, teratogenicity, hormonal disturbances and damage to reproductive organs were introduced by the Pesticide Law enacted in 1989. As far as health is concerned, law enforcement is additionally regulated by rules issued by the federal health authority (National Agency for Health Surveillance – ANVISA. Contrasting to the European Union’s hazard-based cut-off criteria for pesticides, Brazilian rules do not make an exception for “negligible” exposures. Moreover, Brazilian regulations have shortcomings (e.g. no reference to relevance of Mode of Action to humans that make cut-off criteria difficult to be put into effect. The deficiencies of regulations and difficulties to consistently apply the hazard-based cut-off criteria are appraised in this article. Adoption of a risk assessment approach or cut-off criteria based on classification into the Globally Harmonized System’s hazard categories 1A and 1B is suggested. Resumo O Brasil, líder mundial do consumo de agro-químicos, adota uma singular abordagem para registro de agrotóxicos que é baseada em critérios de exclusão quanto à periculosidade. Critérios de exclusão para mutagenicidade, carcinogenicidade, teratogenicidade, distúrbios hormonais e dano a órgãos reprodutivos foram introduzidos pela Lei de Agrotóxicos promulgada em 1989. Em relação à saúde, a aplicação da lei é também regulada por portarias publicadas pela autoridade sanitária federal (Agência Nacional de Vigilância Sanitária – ANVISA. Em contraste com os critérios de exclusão baseados na periculosidade que a União Européia usa para agrotóxicos, a regulamentação brasileira não faz exceção para exposições insignificantes. Além disso, a regulamentação brasileira apresenta deficiências (e.g., não faz men

  12. Thermodynamic efficiency limits of classical and bifacial multi-junction tandem solar cells: An analytical approach

    Science.gov (United States)

    Alam, Muhammad Ashraful; Khan, M. Ryyan

    2016-10-01

    Bifacial tandem cells promise to reduce three fundamental losses (i.e., above-bandgap, below bandgap, and the uncollected light between panels) inherent in classical single junction photovoltaic (PV) systems. The successive filtering of light through the bandgap cascade and the requirement of current continuity make optimization of tandem cells difficult and accessible only to numerical solution through computer modeling. The challenge is even more complicated for bifacial design. In this paper, we use an elegantly simple analytical approach to show that the essential physics of optimization is intuitively obvious, and deeply insightful results can be obtained with a few lines of algebra. This powerful approach reproduces, as special cases, all of the known results of conventional and bifacial tandem cells and highlights the asymptotic efficiency gain of these technologies.

  13. Production of multicharged metal ion beams on the first stage of tandem-type ECRIS

    Energy Technology Data Exchange (ETDEWEB)

    Hagino, Shogo, E-mail: hagino@nf.eie.eng.osaka-u.ac.jp; Nagaya, Tomoki; Nishiokada, Takuya; Otsuka, Takuro; Sato, Fuminobu; Kato, Yushi [Graduate School of Engineering, Osaka University, 2-1 Yamada-oka, Suita-shi, Osaka 565-0871 (Japan); Muramatsu, Masayuki; Kitagawa, Atsushi [National Institute of Radiological Sciences (NIRS), 4-9-1, Anagawa, Inage-ku, Chiba-shi, Chiba 263-8555 (Japan)

    2016-02-15

    Multicharged metal ion beams are required to be applied in a wide range of fields. We aim at synthesizing iron-endohedral fullerene by transporting iron ion beams from the first stage into the fullerene plasma in the second stage of the tandem-type electron cyclotron resonance ion source (ECRIS). We developed new evaporators by using a direct ohmic heating method and a radiation heating method from solid state pure metal materials. We investigate their properties in the test chamber and produce iron ions on the first stage of the tandem-type ECRIS. As a result, we were successful in extracting Fe{sup +} ion beams from the first stage and introducing Fe{sup +} ion beams to the second stage. We will try synthesizing iron-endohedral fullerene on the tandem-type ECRIS by using these evaporators.

  14. Producing multicharged fullerene ion beam extracted from the second stage of tandem-type ECRIS

    Energy Technology Data Exchange (ETDEWEB)

    Nagaya, Tomoki, E-mail: nagaya@nf.eie.eng.osaka-u.ac.jp; Nishiokada, Takuya; Hagino, Shogo; Otsuka, Takuro; Sato, Fuminobu; Kato, Yushi [Graduate School of Engineering, Osaka University, 2-1 Yamada-oka, Suita-shi, Osaka 565-0871 (Japan); Uchida, Takashi [Graduate School of Interdisciplinary New Science, Toyo University, 2100, Kujirai, Kawagoe-shi, Saitama 350-8585 (Japan); Bio-Nano Electronics Research Centre, Toyo University, 2100, Kujirai, Kawagoe-shi, Saitama 350-8585 (Japan); Muramatsu, Masayuki; Kitagawa, Atsushi [National Institute of Radiological Sciences (NIRS), 4-9-1 Anagawa, Inage-ku, Chiba-shi, Chiba 263-8555 (Japan); Yoshida, Yoshikazu [Graduate School of Interdisciplinary New Science, Toyo University, 2100, Kujirai, Kawagoe-shi, Saitama 350-8585 (Japan); Faculty of Science and Engineering, Toyo University, 2100, Kujirai, Kawagoe-shi, Saitama 350-8585 (Japan)

    2016-02-15

    We have been constructing the tandem-type electron cyclotron resonance ion source (ECRIS). Two ion sources of the tandem-type ECRIS are possible to generate plasma individually, and they also confined individual ion species by each different plasma parameter. Hence, it is considered to be suitable for new materials production. As the first step, we try to produce and extract multicharged C{sub 60} ions by supplying pure C{sub 60} vapor in the second stage plasma because our main target is producing the endohedral fullerenes. We developed a new evaporator to supply fullerene vapor, and we succeeded in observation about multicharged C{sub 60} ion beam in tandem-type ECRIS for the first time.

  15. Rapidly convergent algorithms for 3-D tandem and stellarator equilibria in the paraxial approximation

    Energy Technology Data Exchange (ETDEWEB)

    McNamara, B.

    1984-04-01

    Tandem and stellarator equilibria at high ..beta.. have proved hard to compute and the relaxation methods of Bauer et al., Chodura and Schluter, Hirshman, Strauss, and Pearlstein et al. have been slow to converge. This paper reports an extension of the low-..beta.. analytic method of Pearlstein, Kaiser, and Newcomb to arbitrary ..beta.. for tandem mirrors which converges in 10 to 20 iterations. Extensions of the method to stellarator equilibria are proposed and are very close to the analytic method of Johnson and Greene - the stellarator expansion. Most of the results of all these calculations can be adequately described by low-..beta.. approximations since the MHD stability limits occur at low ..beta... The tandem mirror, having weak curvature and a long central cell, allows finite Larmor radius effects to eliminate most ballooning modes and offers the possibility of really high average ..beta... This is the interest in developing such three-dimensional numerical algorithms.

  16. Small-scale experimental tests of tandem mirror machines with thermal barriers

    Energy Technology Data Exchange (ETDEWEB)

    Drake, R.P.

    1979-09-01

    A summary is given of current physical understanding of tandem mirrors with thermal barriers. Physicists who understand tandem mirrors can use this document as a preliminary guide to the physical issues and experimental problems involved. This report will focus upon the issues that can be tested experimentally, and on the areas needing experimental and theoretical inventions. The next section discusses the plasma potentials and plasma confinement which correspond to a tandem mirror with thermal barriers, assuming the barriers exist in steady-state. The creation of a barrier is discussed, i.e., the natural tendency of the barrier cell to fill with plasma must be countered by pumping ions out of the barrier. The design of a barrier-pumping experiment for TMX is described.

  17. Design of two-photon molecular tandem architectures for solar cells by ab initio theory

    DEFF Research Database (Denmark)

    Ørnsø, Kristian Baruël; García Lastra, Juan Maria; De La Torre, Gema

    2015-01-01

    An extensive database of spectroscopic properties of molecules from ab initio calculations is used to design molecular complexes for use in tandem solar cells that convert two photons into a single electron–hole pair, thereby increasing the output voltage while covering a wider spectral range...... of the structural and energetic properties of several thousand porphyrin dyes. The third design is a molecular analogy of the intermediate band solar cell, and involves a single dye molecule with strong intersystem crossing to ensure a long lifetime of the intermediate state. Based on the calculated energy levels...... and molecular orbitals, energy diagrams are presented for the individual steps in the operation of such tandem solar cells. We find that theoretical open circuit voltages of up to 1.8 V can be achieved using these tandem designs. Questions about the practical implementation of prototypical devices...

  18. Perovskite Solar Cells with Large-Area CVD-Graphene for Tandem Solar Cells.

    Science.gov (United States)

    Lang, Felix; Gluba, Marc A; Albrecht, Steve; Rappich, Jörg; Korte, Lars; Rech, Bernd; Nickel, Norbert H

    2015-07-16

    Perovskite solar cells with transparent contacts may be used to compensate for thermalization losses of silicon solar cells in tandem devices. This offers a way to outreach stagnating efficiencies. However, perovskite top cells in tandem structures require contact layers with high electrical conductivity and optimal transparency. We address this challenge by implementing large-area graphene grown by chemical vapor deposition as a highly transparent electrode in perovskite solar cells, leading to identical charge collection efficiencies. Electrical performance of solar cells with a graphene-based contact reached those of solar cells with standard gold contacts. The optical transmission by far exceeds that of reference devices and amounts to 64.3% below the perovskite band gap. Finally, we demonstrate a four-terminal tandem device combining a high band gap graphene-contacted perovskite top solar cell (Eg = 1.6 eV) with an amorphous/crystalline silicon bottom solar cell (Eg = 1.12 eV).

  19. Probing Photocurrent Nonuniformities in the Subcells of Monolithic Perovskite/Silicon Tandem Solar Cells

    KAUST Repository

    Song, Zhaoning

    2016-11-23

    Perovskite/silicon tandem solar cells with high power conversion efficiencies have the potential to become a commercially viable photovoltaic option in the near future. However, device design and optimization is challenging because conventional characterization methods do not give clear feedback on the localized chemical and physical factors that limit performance within individual subcells, especially when stability and degradation is a concern. In this study, we use light beam induced current (LBIC) to probe photocurrent collection nonuniformities in the individual subcells of perovskite/silicon tandems. The choices of lasers and light biasing conditions allow efficiency-limiting effects relating to processing defects, optical interference within the individual cells, and the evolution of water-induced device degradation to be spatially resolved. The results reveal several types of microscopic defects and demonstrate that eliminating these and managing the optical properties within the multilayer structures will be important for future optimization of perovskite/silicon tandem solar cells.

  20. Modeling, simulation and identification for control of tandem cold metal rolling

    Directory of Open Access Journals (Sweden)

    Péricles Guedes Alves

    2012-12-01

    Full Text Available This paper describes a modeling procedure for tandem cold metal rolling, including the linearization step and system identification for control. The tandem cold rolling process is described by a mathematical model based on algebraic equations developed for control purposes and empirical relations. A state-space model is derived and detailed analyses in open loop are presented, concerning the sensitivity with regard to the variations in process parameters and results for the application of a new subspace identification method are compared with classical methodologies. Therefore, this work intents to be a contribution for developments in new control strategies for tandem cold rolling process that offer the potential to reduce the design efforts, the commissioning time and maintenance in rolling mills. The preliminary results obtained with this model have shown reasonable agreement with operational data presented at literature for industrial cold rolling process.

  1. Numerical Study of Atmospheric Icing on Non Rotating Circular Cylinders in Tandem Arrangement

    Directory of Open Access Journals (Sweden)

    Muhammad S. Virk

    2013-03-01

    Full Text Available Numerical study of atmospheric ice accretion on two non-rotating circular cylinders in tandem arrangement was carried out at different operating and geometric conditions. To validate the numerical model, initially the results of ice accretion on single circular cylinder were compared with the experimental data obtained from CIGELE atmospheric icing research wind tunnel (CAIRWT [1, 2]. A good agreement was found between experimental and numerical results. Numerical analyses of ice accretion on two circular cylinders in tandem arrangement showed that accreted ice loads decreases with the increase in distance between the cylinders and also affects the rate and shape of ice accretion. Parametric study at different droplet sizes and temperatures showed a significant change in ice accretion. This research work provides a useful base for better understanding and further investigation of atmospheric ice accretion on circular overhead power network cables in tandem arrangement, installed in the cold regions.

  2. Fourier transform two-dimensional fluorescence excitation spectrometer by using tandem Fabry-Pérot interferometer.

    Science.gov (United States)

    Anzai, Hiroshi; Joshi, Neeraj Kumar; Fuyuki, Masanori; Wada, Akihide

    2015-01-01

    A Fourier transform two-dimensional fluorescence excitation spectrometer (FT-2DFES) was developed based on the multiplex technique using a tandem Fabry-Pérot interferometer (tandem FPI). In addition to the advantage of the multiplex technique, the main advantage of the tandem FPI is applicable to the modulation of transition with a large absorption bandwidth (larger than 100 nm) and is thus applicable to the modulation of the excitation of molecules in the condensed phase. As a demonstration of the effectiveness of FT-2DFES, we succeeded in separately observing the fluorescence excitation peaks from a mixed methanol solution of laser dyes (coumarin 480, rhodamine 6G, DCM (4-dicyanomethylene-2-methyl-6-(p-(dimethylamino)styryl)-4H-pyran), and LDS750). Furthermore, the energy transfer from rhodamine 6G to LDS750 was observed.

  3. Probing Photocurrent Nonuniformities in the Subcells of Monolithic Perovskite/Silicon Tandem Solar Cells.

    Science.gov (United States)

    Song, Zhaoning; Werner, Jérémie; Shrestha, Niraj; Sahli, Florent; De Wolf, Stefaan; Niesen, Björn; Watthage, Suneth C; Phillips, Adam B; Ballif, Christophe; Ellingson, Randy J; Heben, Michael J

    2016-12-15

    Perovskite/silicon tandem solar cells with high power conversion efficiencies have the potential to become a commercially viable photovoltaic option in the near future. However, device design and optimization is challenging because conventional characterization methods do not give clear feedback on the localized chemical and physical factors that limit performance within individual subcells, especially when stability and degradation is a concern. In this study, we use light beam induced current (LBIC) to probe photocurrent collection nonuniformities in the individual subcells of perovskite/silicon tandems. The choices of lasers and light biasing conditions allow efficiency-limiting effects relating to processing defects, optical interference within the individual cells, and the evolution of water-induced device degradation to be spatially resolved. The results reveal several types of microscopic defects and demonstrate that eliminating these and managing the optical properties within the multilayer structures will be important for future optimization of perovskite/silicon tandem solar cells.

  4. Solution-processed organic tandem solar cells with power conversion efficiencies >12%

    Science.gov (United States)

    Li, Miaomiao; Gao, Ke; Wan, Xiangjian; Zhang, Qian; Kan, Bin; Xia, Ruoxi; Liu, Feng; Yang, Xuan; Feng, Huanran; Ni, Wang; Wang, Yunchuang; Peng, Jiajun; Zhang, Hongtao; Liang, Ziqi; Yip, Hin-Lap; Peng, Xiaobin; Cao, Yong; Chen, Yongsheng

    2016-12-01

    An effective way to improve the power conversion efficiency of organic solar cells is to use a tandem architecture consisting of two subcells, so that a broader part of the solar spectrum can be used and the thermalization loss of photon energy can be minimized. For a tandem cell to work well, it is important for the subcells to have complementary absorption characteristics and generate high and balanced (matched) currents. This requires a rather challenging effort to design and select suitable active materials for use in the subcells. Here, we report a high-performance solution-processed, tandem solar cell based on the small molecules DR3TSBDT and DPPEZnP-TBO, which offer efficient, complementary absorption when used as electron donor materials in the front and rear subcells, respectively. Optimized devices achieve a power conversion efficiency of 12.50% (verified 12.70%), which represents a new level of capability for solution-processed, organic solar cells.

  5. Significant light absorption enhancement in silicon thin film tandem solar cells with metallic nanoparticles.

    Science.gov (United States)

    Cai, Boyuan; Li, Xiangping; Zhang, Yinan; Jia, Baohua

    2016-05-13

    Enhancing the light absorption in microcrystalline silicon bottom cell of a silicon-based tandem solar cell for photocurrent matching holds the key to achieving the overall solar cell performance breakthroughs. Here, we present a concept for significantly improving the absorption of both subcells simultaneously by simply applying tailored metallic nanoparticles both on the top and at the rear surfaces of the solar cells. Significant light absorption enhancement as large as 56% has been achieved in the bottom subcells. More importantly the thickness of the microcrystalline layer can be reduced by 57% without compromising the optical performance of the tandem solar cell, providing a cost-effective strategy for high performance tandem solar cells.

  6. Light-trapping design for thin-film silicon-perovskite tandem solar cells

    Science.gov (United States)

    Foster, Stephen; John, Sajeev

    2016-09-01

    Using finite-difference time-domain simulations, we investigate the optical properties of tandem silicon/perovskite solar cells with a photonic crystal architecture, consisting of a square-lattice array of inverted pyramids with a center-to-center spacing of 2.5 μm. We demonstrate that near-perfect light-trapping and absorption can be achieved over the 300-1100 nm wavelength range with this architecture, using less than 10 μm (equivalent bulk thickness) of crystalline silicon. Using a one-diode model, we obtain projected efficiencies of over 30% for the two-terminal tandem cell under a current-matching condition, well beyond the current record for single-junction silicon solar cells. The architecture is amenable to mass fabrication through wet-etching and uses a fraction of the silicon of traditional designs, making it an attractive alternative to other silicon-perovskite tandem designs.

  7. Production of multicharged metal ion beams on the first stage of tandem-type ECRIS

    Science.gov (United States)

    Hagino, Shogo; Nagaya, Tomoki; Nishiokada, Takuya; Otsuka, Takuro; Muramatsu, Masayuki; Kitagawa, Atsushi; Sato, Fuminobu; Kato, Yushi

    2016-02-01

    Multicharged metal ion beams are required to be applied in a wide range of fields. We aim at synthesizing iron-endohedral fullerene by transporting iron ion beams from the first stage into the fullerene plasma in the second stage of the tandem-type electron cyclotron resonance ion source (ECRIS). We developed new evaporators by using a direct ohmic heating method and a radiation heating method from solid state pure metal materials. We investigate their properties in the test chamber and produce iron ions on the first stage of the tandem-type ECRIS. As a result, we were successful in extracting Fe+ ion beams from the first stage and introducing Fe+ ion beams to the second stage. We will try synthesizing iron-endohedral fullerene on the tandem-type ECRIS by using these evaporators.

  8. Method of Hydrogenous Fuel Usage to Increase the Efficiency in Tandem Diverse Temperature Oxidation System

    Directory of Open Access Journals (Sweden)

    Zubkova Marina

    2016-01-01

    Full Text Available This paper presents the results of estimation energy efficiency, the collation data of thermodynamic calculations and data on material balance for an assessment of electric and thermal components in considered ways to use convention products, performance enhancement in the tandem system containing the high-temperature fuel cell and the low-temperature fuel cell with full heat regeneration for hydrogenous fuel (CH4. The overall effective efficiency (ηΣef. making full use of the recovered heat considered tandem system depends on the efficiency of its constituent fuel cells. The overall effective efficiency of the tandem installation including the fuel converter, separating system, high-temperature oxidation system, and hydrogen disposal system in case of fuel use in the low-temperature fuel cell, is higher than for each of the fuel cell elements separately.

  9. Optimizing Algorithm Choice for Metaproteomics: Comparing X!Tandem and Proteome Discoverer for Soil Proteomes

    Science.gov (United States)

    Diaz, K. S.; Kim, E. H.; Jones, R. M.; de Leon, K. C.; Woodcroft, B. J.; Tyson, G. W.; Rich, V. I.

    2014-12-01

    The growing field of metaproteomics links microbial communities to their expressed functions by using mass spectrometry methods to characterize community proteins. Comparison of mass spectrometry protein search algorithms and their biases is crucial for maximizing the quality and amount of protein identifications in mass spectral data. Available algorithms employ different approaches when mapping mass spectra to peptides against a database. We compared mass spectra from four microbial proteomes derived from high-organic content soils searched with two search algorithms: 1) Sequest HT as packaged within Proteome Discoverer (v.1.4) and 2) X!Tandem as packaged in TransProteomicPipeline (v.4.7.1). Searches used matched metagenomes, and results were filtered to allow identification of high probability proteins. There was little overlap in proteins identified by both algorithms, on average just ~24% of the total. However, when adjusted for spectral abundance, the overlap improved to ~70%. Proteome Discoverer generally outperformed X!Tandem, identifying an average of 12.5% more proteins than X!Tandem, with X!Tandem identifying more proteins only in the first two proteomes. For spectrally-adjusted results, the algorithms were similar, with X!Tandem marginally outperforming Proteome Discoverer by an average of ~4%. We then assessed differences in heat shock proteins (HSP) identification by the two algorithms by BLASTing identified proteins against the Heat Shock Protein Information Resource, because HSP hits typically account for the majority signal in proteomes, due to extraction protocols. Total HSP identifications for each of the 4 proteomes were approximately ~15%, ~11%, ~17%, and ~19%, with ~14% for total HSPs with redundancies removed. Of the ~15% average of proteins from the 4 proteomes identified as HSPs, ~10% of proteins and spectra were identified by both algorithms. On average, Proteome Discoverer identified ~9% more HSPs than X!Tandem.

  10. Exact Tandem Repeats Analyzer (E-TRA): A new program for DNA sequence mining

    Indian Academy of Sciences (India)

    Mehmet Karaca; Mehmet Bilgen; A. Naci Onus; Ayse Gul Ince; Safinaz Y. Elmasulu

    2005-04-01

    Exact Tandem Repeats Analyzer 1.0 (E-TRA) combines sequence motif searches with keywords such as ‘organs’, ‘tissues’, ‘cell lines’ and ‘development stages’ for finding simple exact tandem repeats as well as non-simple repeats. E-TRA has several advanced repeat search parameters/options compared to other repeat finder programs as it not only accepts GenBank, FASTA and expressed sequence tags (EST) sequence files, but also does analysis of multiple files with multiple sequences. The minimum and maximum tandem repeat motif lengths that E-TRA finds vary from one to one thousand. Advanced user defined parameters/options let the researchers use different minimum motif repeats search criteria for varying motif lengths simultaneously. One of the most interesting features of genomes is the presence of relatively short tandem repeats (TRs). These repeated DNA sequences are found in both prokaryotes and eukaryotes, distributed almost at random throughout the genome. Some of the tandem repeats play important roles in the regulation of gene expression whereas others do not have any known biological function as yet. Nevertheless, they have proven to be very beneficial in DNA profiling and genetic linkage analysis studies. To demonstrate the use of E-TRA, we used 5,465,605 human EST sequences derived from 18,814,550 GenBank EST sequences. Our results indicated that 12.44% (679,800) of the human EST sequences contained simple and non-simple repeat string patterns varying from one to 126 nucleotides in length. The results also revealed that human organs, tissues, cell lines and different developmental stages differed in number of repeats as well as repeat composition, indicating that the distribution of expressed tandem repeats among tissues or organs are not random, thus differing from the un-transcribed repeats found in genomes.

  11. Short Tandem Repeats in Human Exons: A Target for Disease Mutations

    Directory of Open Access Journals (Sweden)

    Villesen Palle

    2008-09-01

    Full Text Available Abstract Background In recent years it has been demonstrated that structural variations, such as indels (insertions and deletions, are common throughout the genome, but the implications of structural variations are still not clearly understood. Long tandem repeats (e.g. microsatellites or simple repeats are known to be hypermutable (indel-rich, but are rare in exons and only occasionally associated with diseases. Here we focus on short (imperfect tandem repeats (STRs which fall below the radar of conventional tandem repeat detection, and investigate whether STRs are targets for disease-related mutations in human exons. In particular, we test whether they share the hypermutability of the longer tandem repeats and whether disease-related genes have a higher STR content than non-disease-related genes. Results We show that validated human indels are extremely common in STR regions compared to non-STR regions. In contrast to longer tandem repeats, our definition of STRs found them to be present in exons of most known human genes (92%, 99% of all STR sequences in exons are shorter than 33 base pairs and 62% of all STR sequences are imperfect repeats. We also demonstrate that STRs are significantly overrepresented in disease-related genes in both human and mouse. These results are preserved when we limit the analysis to STRs outside known longer tandem repeats. Conclusion Based on our findings we conclude that STRs represent hypermutable regions in the human genome that are linked to human disease. In addition, STRs constitute an obvious target when screening for rare mutations, because of the relatively low amount of STRs in exons (1,973,844 bp and the limited length of STR regions.

  12. Tandem repeat markers as novel diagnostic tools for high resolution fingerprinting of Wolbachia

    Directory of Open Access Journals (Sweden)

    Riegler Markus

    2012-01-01

    Full Text Available Abstract Background Strains of the endosymbiotic bacterium Wolbachia pipientis are extremely diverse both genotypically and in terms of their induced phenotypes in invertebrate hosts. Despite extensive molecular characterisation of Wolbachia diversity, little is known about the actual genomic diversity within or between closely related strains that group tightly on the basis of existing gene marker systems, including Multiple Locus Sequence Typing (MLST. There is an urgent need for higher resolution fingerprinting markers of Wolbachia for studies of population genetics, horizontal transmission and experimental evolution. Results The genome of the wMel Wolbachia strain that infects Drosophila melanogaster contains inter- and intragenic tandem repeats that may evolve through expansion or contraction. We identified hypervariable regions in wMel, including intergenic Variable Number Tandem Repeats (VNTRs, and genes encoding ankyrin (ANK repeat domains. We amplified these markers from 14 related Wolbachia strains belonging to supergroup A and were successful in differentiating size polymorphic alleles. Because of their tandemly repeated structure and length polymorphism, the markers can be used in a PCR-diagnostic multilocus typing approach, analogous to the Multiple Locus VNTR Analysis (MLVA established for many other bacteria and organisms. The isolated markers are highly specific for supergroup A and not informative for other supergroups. However, in silico analysis of completed genomes from other supergroups revealed the presence of tandem repeats that are variable and could therefore be useful for typing target strains. Conclusions Wolbachia genomes contain inter- and intragenic tandem repeats that evolve through expansion or contraction. A selection of polymorphic tandem repeats is a novel and useful PCR diagnostic extension to the existing MLST typing system of Wolbachia, as it allows rapid and inexpensive high-throughput fingerprinting of

  13. Implementação do Custeio Baseado em Atividades para Gestão dos Gastos de uma Empresa de Serviços Alimentícios = Implementation of activity based costing for expenditure management of a food service company

    Directory of Open Access Journals (Sweden)

    Henrique Torres Cavalcante

    2014-04-01

    Full Text Available O artigo tem por objetivo demonstrar a implementação do custeio baseado em atividades para gestão dos gastos de uma empresa de serviços alimentícios. Foi empreendido um estudo descritivo, por meio de um estudo de caso, com abordagem qualitativa. Os instrumentos utilizados na coleta dos dados foram entrevistas e dados primários. Para análise e tratamento dos dados, utilizou-se a análise descritiva. A proposta, fundamentada no custeio baseado em atividades e no estudo desenvolvido por Lippel (2002, considerou a realidade vivenciada pelo restaurante e possibilitou a identificação dos processos e atividades existentes, dos custos de tais processos e atividades, a alocação desses custos aos produtos, bem como a alocação dos gastos relativos à matéria-prima, mão de obra e despesas diversas aos também produtos. A proposta permite analisar informações quanto à lucratividade de cada prato, preço de venda e quantidade vendida, podendo o gestor ponderar a melhor composição do seu cardápio, mix de produtos ofertados e optar pelos pratos que representam a melhor relação custo-benefício para o restaurante. The goal of this paper is to demonstrate the implementation of activity based costing for expenditure management of a food service company. A descriptive study was carried out through a case study with qualitative approach. The instruments used in data collection were interviews and primary data. Descriptive analysis was used for data analysis and processing. The proposal built on activity based costing and on the study developed by Lippel (2002 considered the reality experienced by the restaurant and enabled the identification of the existing processes and activities, the costs of such processes and activities, the costs allocated to these products as well as the allocation of expenditure regarding raw materials, labor and other expenses from the products. The proposal allows analyzing information regarding the profitability of

  14. Tandem-pumped 1120-nm actively Q-switched fiber laser

    Institute of Scientific and Technical Information of China (English)

    王建华; 胡金萌; 张世强; 陈露璐; 房勇; 冯衍

    2015-01-01

    We report on a tandem-pumped actively Q-switched fiber laser system emitting at 1120 nm. Parasitic oscillation is challenging in Yb-doped Q-switched 1120-nm fiber laser, which is suppressed by pumping with a fiber laser at 1018 nm. At least 4 times improvement in output peak power is demonstrated in a single laser setup with 1018-nm fiber laser pumping instead of 976-nm laser diode pumping. This is, to the best of our knowledge, the first demonstration of a tandem-pumped Q-switched fiber laser.

  15. Development of Tandem Accelerator Mixed Target Cone and Its Application for Single Event Effects Experiments

    Institute of Scientific and Technical Information of China (English)

    CAI; Li; SHEN; Dong-jun; YOU; Qu-bo; WANG; Hui

    2012-01-01

    <正>For carrying out heavy ion single event effects (SEE) test, the tandem accelerator has the advantage of rapid replacement of ion species, making it possible to replace 5 or 6 kinds of ion in one experiment (about 20 h) and get complete cross-section curve for devices under test (DUTs). In order to achieve the purpose of rapid replacement of ion species, multi-element mixed target cone using in tandem accelerator has been developed. In this way variety of ions can be extracted in one target cone, the time of replacing target cone can be saved, thereby further raise efficiency of experiment.

  16. High Precision Prediction of Rolling Force Based on Fuzzy and Nerve Method for Cold Tandem Mill

    Institute of Scientific and Technical Information of China (English)

    JIA Chun-yu; SHAN Xiu-ying; NIU Zhao-ping

    2008-01-01

    The rolling force model for cold tandem mill was put forward by using the Elman dynamic recursive network method, based on the actual measured data. Furthermore, a good assumption is put forward, which brings a full universe of discourse self-adjusting factor fuzzy control, closed-loop adjusting, based on error feedback and expertise into a rolling force prediction model, to modify prediction outputs and improve prediction precision and robustness. The simulated results indicate that the method is highly effective and the prediction precision is better than that of the traditional method. Predicted relative error is less than ±4%, so the prediction is high precise for the cold tandem mill.

  17. High efficiency AIGaAs/Si monolithic tandem solar cell grown by metalorganic chemical vapor deposition

    OpenAIRE

    Tetsuo, Soga; T.", "Kato; M., Yang; Masayoshi, Umeno; Takashi, Jimbo

    1995-01-01

    The improvements of the AlGaAs solar cell grown on the Si substrate and the AlGaAs/Si tandem solar cell by metalorganic chemical vapor deposition have been investigated. The active‐area conversion efficiency of the Al0.1Ga0.9As solar cell on the Si substrate as high as 12.9% has been obtained by improving the growth sequence and adopting an Al compositionally graded band emitter layer. A high efficiency monolithic AlGaAs/Si tandem solar cell with the active‐area conversion efficiency of 19.9%...

  18. Very high frequency plasma deposited amorphous/nanocrystalline silicon tandem solar cells on flexible substrates

    Science.gov (United States)

    Liu, Y.

    2010-02-01

    The work in this thesis is to develop high quality intrinsic layers (especially nc-Si:H) for micromorph silicon tandem solar cells/modules on plastic substrates following the substrate transfer method or knows as the Helianthos procedure. Two objectives are covered in this thesis: (1) preliminary work on trial and optimization of single junction and tandem cells on glass substrate, (2) silicon film depositions on Al foil, and afterwards the characterization and development of these cells/modules on a plastic substrate. The first objective includes the development of suitable ZnO:Al TCO for nc Si:H single junction solar cells, fabrication of the aimed micromorph tandem solar cells on glass, and finally the optimization of the nc-Si:H i-layer for the depositions afterwards on Al foil. Chapter 3 addresses the improvement of texture etching of ZnO:Al by studying the HCl etching effect on ZnO:Al films sputter-deposited in a set substrate heater temperature series. With the texture-etched ZnO:Al front TCO, a single junction nc-Si:H solar cell was deposited with an initial efficiency of 8.33%. Chapter 4 starts with studying the light soaking and annealing effects on micromorph tandem solar cell. In the end, a highly stabilized bottom cell current limited tandem cell was made. The tandem shows an initial efficiency of 10.2%, and degraded only 6.9% after 1600 h of light soaking. In Chapter 5, the nc-Si:H i-layers were studied in 3 pressure and inter-electrode distance series. The correlations between plasma physics and the consequent i-layers’ properties are investigated. We show that the Raman crystalline ratio and porosity of the nc-Si:H layer have an interesting relation with the p•d product. By varying p and d, device quality nc-Si:H layer can be deposited at a high rate of 0.6 nm/s. These results in fact are a very important step for the second objective. The second objective is covered by the entire Chapter 6. All silicon layers are deposited on special aluminum

  19. A Flexible Web-Based Approach to Modeling Tandem Photocatalytic Devices

    DEFF Research Database (Denmark)

    Seger, Brian; Hansen, Ole; Vesborg, Peter Christian Kjærgaard

    2017-01-01

    There have been several works modeling the optimal band gaps for tandem photocatalytic water splitting devices under different assumptions. Due to the many parameters involved, it is impossible for the authors to consider every conceivable situation. In this work, we have developed a web-based mo......There have been several works modeling the optimal band gaps for tandem photocatalytic water splitting devices under different assumptions. Due to the many parameters involved, it is impossible for the authors to consider every conceivable situation. In this work, we have developed a web...... previous experimental photoelectrodes, and quantitatively relates their performance to what would typically be expected via modeling programs....

  20. Analysis of Tandem Repeat Patterns in Nlrc4 using a Motif Model

    Directory of Open Access Journals (Sweden)

    Sim-Hui Tee

    2012-12-01

    Full Text Available Exponential accumulation of biological data requires computer scientists and bioinformaticians to improve the efficiency of computer algorithms and databases. The recent advancement of computational tools has boosted the processing capacity of enormous volume of genetic data. This research applied a computational approach to analyze the tandem repeat patterns in Nlrc4 gene. Because the protein product of Nlrc4 gene is important in detecting pathogen and triggering subsequent immune responses, the results of this genetic analysis is essential for the understanding of the genetic characteristics of Nlrc4. The study on the distribution of tandem repeats may provide insights for drug design catered for the Nlrc4-implicated diseases.

  1. High efficiency tandem organic light-emitting devices with Al/WO3/Au interconnecting layer

    OpenAIRE

    2007-01-01

    An interconnecting layer of Al (2 nm)/WO3 (3 nm)/Au (16 nm) was studied for application in tandem organic light-emitting devices. It can be seen that the Al/WO3/Au structure plays the role of an excellent interconnecting layer. The introduction of WO3 in the connection unit significantly improves the device efficiency as compared to the case of Al/Au. Thus, the current efficiency of the two-unit tandem devices is enhanced by two factors with respect to the one-unit devices. The green two-u...

  2. Improved set of short-tandem-repeat polymorphisms for screening the human genome

    Energy Technology Data Exchange (ETDEWEB)

    Yuan, Bo; Vaske, D.; Weber, J.L. [Marshfield Medical Research Foundation, WI (United States)] [and others

    1997-02-01

    Short-tandem-repeat (microsatellite) DNA polymorphisms are widely used for screening the human and other genomes in initial linkage mapping. Since the average spacing between polymorphisms in genome screens is usually {ge}10 cM and since many thousands of human short-tandem-repeat polymorphisms (STRPs) are now available, optimal subsets of STRPs must be selected for screening. Two screening sets of STRPs for humans have been described in the literature, both of which are based primarily on dinucleotide-repeat polymorphisms. Here we describe our eighth and most recent human screening set, which is based almost entirely on trinucleotide-and tetranucleotide-repeat polymorphisms. 7 refs., 1 tab.

  3. Desymmetrization of 7-azabicycloalkenes by tandem olefin metathesis for the preparation of natural product scaffolds

    Directory of Open Access Journals (Sweden)

    Deppermann Nina

    2007-12-01

    Full Text Available Abstract Background Tandem olefin metathesis sequences are known to be versatile for the generation of natural product scaffolds and have also been used for ring opening of strained carbo- and heterocycles. In this paper we demonstrate the potential of these reactions for the desymmetrization of 7-azabicycloalkenes. Results We have established efficient protocols for the desymmetrization of different 7-azabicycloalkenes by intra- and intermolecular tandem metathesis sequences with ruthenium based catalysts. Conclusion Desymmetrization of 7-azabicycloalkenes by olefin metathesis is an efficient process for the preparation of common natural product scaffolds such as pyrrolidines, indolizidines and isoindoles.

  4. Desymmetrization of 7-azabicycloalkenes by tandem olefin metathesis for the preparation of natural product scaffolds

    Science.gov (United States)

    Maison, Wolfgang; Büchert, Marina; Deppermann, Nina

    2007-01-01

    Background Tandem olefin metathesis sequences are known to be versatile for the generation of natural product scaffolds and have also been used for ring opening of strained carbo- and heterocycles. In this paper we demonstrate the potential of these reactions for the desymmetrization of 7-azabicycloalkenes. Results We have established efficient protocols for the desymmetrization of different 7-azabicycloalkenes by intra- and intermolecular tandem metathesis sequences with ruthenium based catalysts. Conclusion Desymmetrization of 7-azabicycloalkenes by olefin metathesis is an efficient process for the preparation of common natural product scaffolds such as pyrrolidines, indolizidines and isoindoles. PMID:18088413

  5. Selective hydroformylation-hydrogenation tandem reaction of isoprene to 3-methylpentanal.

    Science.gov (United States)

    Behr, Arno; Reyer, Sebastian; Tenhumberg, Nils

    2011-11-28

    The hydroformylation of isoprene catalysed by rhodium phosphine complexes usually yields a broad mixture of the monoaldehydes, the isomeric methylpentenals, as well as the dialdehyde 3-methyl-1,6-hexandial. Under usual reaction conditions the products of a consecutive hydrogenation are only formed as minor by-products. Surprisingly we discovered now a selective auto-tandem reaction consisting of a hydroformylation and a hydrogenation step if a rhodium complex with the chelate ligand bis(diphenylphosphino)ethane is used as catalyst. If branched aromatic solvents like cumene are applied the conversion of isoprene is nearly quantitatively and the yield of the tandem product 3-methylpentanal amounts to 85%.

  6. Robust Tension Control of Strip for 5-Stand Tandem Cold Mills

    Directory of Open Access Journals (Sweden)

    Behrooz Shafiei

    2014-01-01

    Full Text Available Tandem cold rolling process is a nonlinear complex system with external and internal uncertainties and significant disturbances. The improvement in the quality of the final output depends on the control strategy of centerline thickness and interstand tension. This paper focuses on interstand tension control problem in 5-stand tandem cold rolling mills. Tension dynamics can be described by a nominal model perturbed by parametric uncertainties. In order to overcome the model uncertainties and external disturbances, suboptimal H∞ and μ controllers are proposed and the Hankel-norm approximation is used to reduce the order of μ controller. The performance of the proposed controllers is demonstrated by some simulations.

  7. GENETIC DIVERSITY OF TYPHA LATIFOLIA (TYPHACEAE) AND THE IMPACT OF POLLUTANTS EXAMINED WITH TANDEM-REPETITIVE DNA PROBES

    Science.gov (United States)

    Genetic diversity at variable-number-tandem-repeat (VNTR) loci was examined in the common cattail, Typha latifolia (Typhaceae), using three synthetic DNA probes composed of tandemly repeated "core" sequences (GACA, GATA, and GCAC). The principal objectives of this investigation w...

  8. Aryl Ketone Synthesis via Tandem Orthoplatinated Triarylphosphite-Catalyzed Addition Reactions of Arylboronic Acids with Aldehydes Followed by Oxidation

    Science.gov (United States)

    Liao, Yuan-Xi; Hu, Qiao-Sheng

    2010-01-01

    Tandem orthoplatinated triarylphosphite-catalyzed addition reactions of arylboronic acids with aldehydes followed by oxidation to yield aryl ketones is described. 3-Pentanone was identified as a suitable oxidant for the tandem aryl ketone formation reaction. By using microwave energy, aryl ketones were obtained in high yields with the catalyst loading as low as 0.01%. PMID:20849092

  9. Zinc tin oxide as high-temperature stable recombination layer for mesoscopic perovskite/silicon monolithic tandem solar cells

    Science.gov (United States)

    Werner, Jérémie; Walter, Arnaud; Rucavado, Esteban; Moon, Soo-Jin; Sacchetto, Davide; Rienaecker, Michael; Peibst, Robby; Brendel, Rolf; Niquille, Xavier; De Wolf, Stefaan; Löper, Philipp; Morales-Masis, Monica; Nicolay, Sylvain; Niesen, Bjoern; Ballif, Christophe

    2016-12-01

    Perovskite/crystalline silicon tandem solar cells have the potential to reach efficiencies beyond those of silicon single-junction record devices. However, the high-temperature process of 500 °C needed for state-of-the-art mesoscopic perovskite cells has, so far, been limiting their implementation in monolithic tandem devices. Here, we demonstrate the applicability of zinc tin oxide as a recombination layer and show its electrical and optical stability at temperatures up to 500 °C. To prove the concept, we fabricate monolithic tandem cells with mesoscopic top cell with up to 16% efficiency. We then investigate the effect of zinc tin oxide layer thickness variation, showing a strong influence on the optical interference pattern within the tandem device. Finally, we discuss the perspective of mesoscopic perovskite cells for high-efficiency monolithic tandem solar cells.

  10. Zinc tin oxide as high-temperature stable recombination layer for mesoscopic perovskite/silicon monolithic tandem solar cells

    KAUST Repository

    Werner, Jérémie

    2016-12-05

    Perovskite/crystalline silicon tandem solar cells have the potential to reach efficiencies beyond those of silicon single-junction record devices. However, the high-temperature process of 500 °C needed for state-of-the-art mesoscopic perovskite cells has, so far, been limiting their implementation in monolithic tandem devices. Here, we demonstrate the applicability of zinc tin oxide as a recombination layer and show its electrical and optical stability at temperatures up to 500 °C. To prove the concept, we fabricate monolithic tandem cells with mesoscopic top cell with up to 16% efficiency. We then investigate the effect of zinc tin oxide layer thickness variation, showing a strong influence on the optical interference pattern within the tandem device. Finally, we discuss the perspective of mesoscopic perovskite cells for high-efficiency monolithic tandem solar cells. © 2016 Author(s)

  11. Linguistic Affordances of Korean-English Tandem Learning: A Case Study of Korean-English On-Line Chat Pair Interaction

    Science.gov (United States)

    Cheon, Heesok

    2012-01-01

    In an attempt to explore an environment for language learning that tandem learning via real-time chat affords to foreign language learners and how language learners respond to those affordances, this study examined learner interaction in online Korean-English Tandem Learning with focus on how tandem learners engaged in peer assistance and how they…

  12. Realizando a Gestão de Relacionamentos com os cidadãos: proposição e avaliação de um modelo baseado no Citizen Relationship Management Performing the Citizen Relationship Management: proposition and assessment of a model based on the Citizen Relationship Management

    Directory of Open Access Journals (Sweden)

    Leonardo de Oliveira Leite

    2010-11-01

    Full Text Available O atendimento efetivo dos cidadãos nos municípios desafia constantemente a gestão das prefeituras,que mostram dificuldades para adequar seus serviços com qualidade. O objetivo deste artigo é propore analisar na prática um modelo de gestão de relacionamentos com os cidadãos, adaptando alguns conceitosde Customer Relationship Management (CRM para prefeituras. Este CRM, baseado na integração dosSistemas de Informação, promove a melhoria dos serviços públicos e a aproximação do gestor municipalao cidadão. O método utilizado foi de uma pesquisa bibliográfica exploratória e de estudo de caso em ummunicípio, utilizando a técnica de entrevista semiestruturada aliada a uma pesquisa documental. A conclusão, baseada nos resultados desta pesquisa, reitera que a gestão do relacionamento com os cidadãos permiteaos gestores municipais conhecer seus cidadãos, personalizando o atendimento, apoiando o processodecisório e melhorando a máquina pública para atender de forma mais efetiva a população.

  13. Model development of monolithic tandem silicon-perovskite solar cell by SCAPS simulation

    Science.gov (United States)

    Ramli, Noor Fadhilah; Sepeai, Suhaila; Rostan, Nur Fairuz Mohd; Ludin, Norasikin Ahmad; Ibrahim, Mohd. Adib; Teridi, Mohd Asri Mat; Zaidi, Salem H.

    2017-05-01

    Organic-inorganic lead halide perovskites have significant role in the photovoltaic (PV) technology due to its high efficiency, lightweight and cost effectiveness especially methyl ammonium lead (II) iodide (MALI). The MALI can act as absorber layer which has a band gap of 1.5 eV which is compatible to be paired with silicon (Si) solar cell with energy gap of 1.124 eV as a tandem solar cell. This tandem approach is an refined solution to improve the efficiency of Si solar cell that has been stuck around 25 % for 15 years. This study focuses on the development of the device configuration model for Si-perovskite tandem solar cell by using SCAPS simulation. The thickness and dopant concentration of perovskite layer have affected the solar cell parameters performance. The efficiency result obtained from SCAPS simulation is 27.29 % for Si-perovskite tandem solar cell with an open circuit voltage of 0.8178 V, short circuit current 43.55 mA/cm2 and fill factor 76.61 %.

  14. Significant light absorption improvement in perovskite/CIGS tandem solar cells with dielectric nanocone structures

    Science.gov (United States)

    Wang, Huahua; Cai, Boyuan; Yuan, Xiaocong

    2017-06-01

    Here, we propose a novel perovskite/CIGS tandem solar cell geometry with tailored dielectric nanocone structure incorporated on the top surface for light manipulation. Absorption enhancement as high as 15.39% has been achieved both in the top and bottom subcells, leading to a 14.29% thickness reduction of the bottom subcell.

  15. Analysis of the performances of an axial flow tandem pump based on CFD computations

    Science.gov (United States)

    Zhao, Y.; Bai, Z. Y.; Zhang, M. D.; Wang, G. Y.

    2012-11-01

    Tandem pump, compared with multistage pump, goes without guide vanes between impellers. Significant reduction of the axial geometry scale, resulting from lack of guide vanes, makes great sense to high-speed propulsion. Direct interactions between front and rear impellers may lead to special flows, which are different from those in a multistage pump. There are few studies of these differences. In this article, CFD computations of flows in an axial flow tandem pump are conducted to predict the performances. FBM turbulence model, which is introduced to commercial software, is used for the simulations. Circulation coefficient is defined to help analyze energy characteristics. The results demonstrate that power of the tandem pump increases slowly as discharge is getting larger. The tandem pump has better adaptability under large discharge conditions. The head of the rear impeller is not sensitive to discharge's change, which results from that the front impeller weakens the influence of discharge's change on the rear impeller, so pump's energy characteristics may be improved.

  16. Functional Diversity of Tandem Substrate-Binding Domains in ABC Transporters from Pathogenic Bacteria

    NARCIS (Netherlands)

    Fulyani, Faizah; Schuurman-Wolters, Gea K.; Vujicic - Zagar, Andreja; Guskov, Albert; Slotboom, Dirk-Jan; Poolman, Bert

    2013-01-01

    The ATP-binding cassette (ABC) transporter GInPQ is an essential uptake system for amino acids in gram-positive pathogens and related nonpathogenic bacteria. The transporter has tandem substrate-binding domains (SBDs) fused to each transmembrane domain, giving rise to four SBDs per functional transp

  17. Controller routines for the DECsystem-10 with application to a tandem-mirror plasma code

    Energy Technology Data Exchange (ETDEWEB)

    Faul, D.R.; Devoto, R.S.

    1979-04-12

    FORTRAN-callable subroutines have been written to enable controller--controllee interaction on the LLL DECsystem-10. These subroutines have been used to construct a controller (XTCTMR) for a tandem-mirror physics code (CTCTMR). A description of the subroutines and their use is presented. Also, sample results are given.

  18. Importance Sampling Simulation of Population Overflow in Two-node Tandem Networks

    NARCIS (Netherlands)

    Nicola, Victor F.; Zaburnenko, Tatiana S.; Baier, C.; Chiola, G.; Smirni, E.

    2005-01-01

    In this paper we consider the application of importance sampling in simulations of Markovian tandem networks in order to estimate the probability of rare events, such as network population overflow. We propose a heuristic methodology to obtain a good approximation to the 'optimal' state-dependent ch

  19. Tandem Ring-Closing Metathesis/Isomerization Reactions for the Total Synthesis of Violacein

    DEFF Research Database (Denmark)

    Petersen, Mette T.; Nielsen, Thomas Eiland

    2013-01-01

    A series of 5-substituted 2-pyrrolidinones was synthesized through a one-pot ruthenium alkylidene-catalyzed tandem RCM/isomerization/nucleophilic addition sequence. The intermediates resulting from RCM/isomerization showed reactivity toward electrophiles in aldol condensation reactions which prov...

  20. Transcription termination between polo and snap, two closely spaced tandem genes of D. melanogaster.

    Science.gov (United States)

    Henriques, Telmo; Ji, Zhe; Tan-Wong, Sue Mei; Carmo, Alexandre M; Tian, Bin; Proudfoot, Nicholas J; Moreira, Alexandra

    2012-01-01

    Transcription termination of RNA polymerase II between closely spaced genes is an important, though poorly understood, mechanism. This is true, in particular, in the Drosophila genome, where approximately 52% of tandem genes are separated by less than 1 kb. We show that a set of Drosophila tandem genes has a negative correlation of gene expression and display several molecular marks indicative of promoter pausing. We find that an intergenic spacing of 168 bp is sufficient for efficient transcription termination between the polo-snap tandem gene pair, by a mechanism that is independent of Pcf11 and Xrn2. In contrast, analysis of a tandem gene pair containing a longer intergenic region reveals that termination occurs farther downstream of the poly(A) signal and is, in this case, dependent on Pcf11 and Xrn2. For polo-snap, displacement of poised polymerase from the snap promoter by depletion of the initiation factor TFIIB results in an increase of polo transcriptional read-through. This suggests that poised polymerase is necessary for transcription termination. Interestingly, we observe that polo forms a TFIIB dependent gene loop between its promoter and terminator regions. Furthermore, in a plasmid containing the polo-snap locus, deletion of the polo promoter causes an increase in snap expression, as does deletion of polo poly(A) signals. Taken together, our results indicate that polo forms a gene loop and polo transcription termination occurs by an Xrn2 and Pcf11 independent mechanism that requires TFIIB.

  1. Three-dimensional photonic crystal intermediate reflectors for enhanced light-trapping in tandem solar cells

    Energy Technology Data Exchange (ETDEWEB)

    Uepping, Johannes; Bielawny, Andreas; Wehrspohn, Ralf B. [Institute of Physics, Martin-Luther-Universitaet Halle-Wittenberg, Halle (Germany); Fraunhofer-Institute for Mechanics of Materials, Halle (Germany); Beckers, Thomas; Carius, Reinhard; Rau, Uwe [Institute of Energy and Climate Research 5 - Photovoltaics, Forschungszentrum Juelich GmbH, Juelich (Germany); Fahr, Stefan; Rockstuhl, Carsten; Lederer, Falk [Institute of Condensed Matter Theory and Solid State Optics and Abbe Center of Photonics, Friedrich-Schiller-Universitaet Jena (Germany); Kroll, Matthias; Pertsch, Thomas [Institute of Applied Physics, Friedrich-Schiller-Universitaet Jena (Germany); Steidl, Lorenz; Zentel, Rudolf [Institute of Organic Chemistry, Johannes Gutenberg-Universitaet Mainz (Germany)

    2011-09-08

    A three-dimensional photonic crystal intermediate reflector for enhanced light trapping in tandem solar cells is presented. The intermediate reflector consists of a transparent and conductive ZnO:Al inverted opal sandwiched in between the top amorphous silicon and bottom microcrystalline silicon cell. (Copyright copyright 2011 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  2. JAERI TANDEM annual report 2000. April 1, 2000 - March 31, 2001

    Energy Technology Data Exchange (ETDEWEB)

    Takeuchi, Suehiro; Ikezoe, Hiroshi; Chiba, Satoshi; Nagame, Yuichiro; Sataka, Masao; Iwamoto, Akira [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment] (eds.)

    2001-11-01

    This annual report describes research activities which have been performed with the JAERI tandem accelerator and the Van de Graaff accelerator from April 1, 2000 to March 31, 2001. Summary reports of 46 papers, and lists of publication, personnel and cooperative research with universities are contained. (author)

  3. Specific tandem repeats are sufficient for paramutation-induced trans-generational silencing

    NARCIS (Netherlands)

    Belele, C.L.; Sidorenko, L.; Stam, M.; Bader, R.; Arteaga-Vazquez, M.A.; Chandler, V.L.

    2013-01-01

    Paramutation is a well-studied epigenetic phenomenon in which trans communication between two different alleles leads to meiotically heritable transcriptional silencing of one of the alleles. Paramutation at the b1 locus involves RNA-mediated transcriptional silencing and requires specific tandem re

  4. Tandem Mannich/Diels–Alder reactions for the synthesis of indole compound libraries

    DEFF Research Database (Denmark)

    Wu, Peng; Petersen, Michael Åxman; Petersen, Rico;

    2016-01-01

    A tandem Mannich/Diels–Alder sequence for the synthesis of small-molecule libraries with an indolyl-octahydro-3a,6-epoxy-isoindole core structure is demonstrated in this study. Representative diversification examples based on this scaffold were performed, and a library is being produced within th...

  5. Tandem affinity purification of functional TAP-tagged proteins from human cells

    NARCIS (Netherlands)

    Gregan, Juraj; Riedel, Christian G; Petronczki, Mark; Cipak, Lubos; Rumpf, Cornelia; Poser, Ina; Buchholz, Frank; Mechtler, Karl; Nasmyth, Kim

    2007-01-01

    Tandem affinity purification (TAP) is a generic two-step affinity purification protocol for isolation of TAP-tagged proteins together with associated proteins. We used bacterial artificial chromosome to heterologously express TAP-tagged murine Sgo1 protein in human HeLa cells. This allowed us to tes

  6. Tandem-pulsed acousto-optics: an analytical framework of modulated high-contrast speckle patterns

    NARCIS (Netherlands)

    Resink, S.G.; Steenbergen, W.

    2015-01-01

    Recently we presented acousto-optic (AO) probing of scattering media using addition or subtraction of speckle patterns due to tandem nanosecond pulses. Here we present a theoretical framework for ideal (polarized, noise-free) speckle patterns with unity contrast that links ultrasound-induced optical

  7. Characterization of rDNAs and Tandem Repeats in the Heterochromatin of Brassica rapa

    NARCIS (Netherlands)

    Lim, K.B.; Jong, de J.H.S.G.M.; Yang, T.J.; Park, J.Y.; Kwon, S.J.; Kim, J.S.; Lim, M.H.; Kim, J.A.; Jin, M.; Jin, Y.M.; Kim, S.H.; Lim, Y.P.; Bang, J.W.; Kim, H.I.; Park, B.S.

    2005-01-01

    We describe the morphology and molecular organization of heterochromatin domains in the interphase nuclei, and mitotic and meiotic chromosomes, of Brassica rapa, using DAPI staining and fluorescence in situ hybridization (FISH) of rDNA and pericentromere tandem repeats. We have developed a simple me

  8. Bio-olefins via tandem isomerization-decarboxylation catalysis upon fatty acids

    Science.gov (United States)

    A facile Ru-catalyzed route to bio-alkenes from alkenoic fatty acids will be discussed. A readily accessible pre-catalyst [Ru(CO)2RCO2]n. apparently functions in a tandem mode by dynamically isomerizing the positions of double bonds in an aliphatic chain and, subsequently, decarboxylating specific i...

  9. De tandem van Medvedev en Poetin: wie heeft de macht in Rusland?

    NARCIS (Netherlands)

    Jansen, M.

    2009-01-01

    Marc Jansen addresses the question who is the real leader in Russia at the moment. In May 2008, Vladimir Putin was succeeded as Russian President by his protégé Dmitrii Medvedev, but he stayed on as Prime Minister. A so-called 'tandem' was created, with Putin as the unchallenged No. 1. Whereas Medve

  10. Hybrid inorganic-organic tandem solar cells for broad absorption of the solar spectrum

    NARCIS (Netherlands)

    Speirs, M. J.; Groeneveld, B. G. H. M.; Protesescu, L.; Piliego, Claudia; Kovalenko, M. V.; Loi, M. A.

    2014-01-01

    We report the first hybrid tandem solar cell with solution processable active layers using colloidal PbS quantum dots (QDs) as the front subcell in combination with a polymer-fullerene rear subcell. Al/WO3 is introduced as an interlayer, yielding an open circuit voltage (V-OC) equal to about 92% of

  11. See-through dye-sensitized solar cells: photonic reflectors for tandem and building integrated photovoltaics.

    Science.gov (United States)

    Heiniger, Leo-Philipp; O'Brien, Paul G; Soheilnia, Navid; Yang, Yang; Kherani, Nazir P; Grätzel, Michael; Ozin, Geoffrey A; Tétreault, Nicolas

    2013-10-25

    See-through dye-sensitized solar cells with 1D photonic crystal Bragg reflector photoanodes show an increase in peak external quantum efficiency of 47% while still maintaining high fill factors, resulting in an almost 40% increase in power conversion efficiency. These photoanodes are ideally suited for tandem and building integrated photovoltaics.

  12. Fully automated screening of veterinary drugs in milk by turbulent flow chromatography and tandem mass spectrometry

    NARCIS (Netherlands)

    Stolker, A.A.M.; Peters, R.J.B.; Zuiderent, R.; DiBussolo, J.M.; Martins, C.P.B.

    2010-01-01

    There is an increasing interest in screening methods for quick and sensitive analysis of various classes of veterinary drugs with limited sample pre-treatment. Turbulent flow chromatography in combination with tandem mass spectrometry has been applied for the first time as an efficient screening met

  13. JAERI tandem annual report 1999. April 1, 1999 - March 31, 2000

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-11-01

    This annual report describes research activities which have been performed with the JAERI tandem accelerator and the Van de Graaff accelerator from April 1, 1999 to March 31, 2000. Summary reports of 49 papers, and lists of publication, personnel and cooperative research with universities are contained. (author)

  14. A Comparison of Tandem Walk Performance Between Bed Rest Subjects and Astronauts

    Science.gov (United States)

    Miller, Chris; Peters, Brian; Kofman, Igor; Philips, Tiffany; Batson, Crystal; Cerisano, Jody; Fisher, Elizabeth; Mulavara, Ajitkumar; Feiveson, Alan; Reschke, Millard; Bloomberg, Jacob

    2015-01-01

    Astronauts experience a microgravity environment during spaceflight, which results in a central reinterpretation of both vestibular and body axial-loading information by the sensorimotor system. Subjects in bed rest studies lie at 6deg head-down in strict bed rest to simulate the fluid shift and gravity-unloading of the microgravity environment. However, bed rest subjects still sense gravity in the vestibular organs. Therefore, bed rest isolates the axial-unloading component, thus allowing for the direct study of its effects. The Tandem Walk is a standard sensorimotor test of dynamic postural stability. In a previous abstract, we compared performance on a Tandem Walk test between bed rest control subjects, and short- and long-duration astronauts both before and after flight/bed rest using a composite index of performance, called the Tandem Walk Parameter (TWP), that takes into account speed, accuracy, and balance control. This new study extends the previous data set to include bed rest subjects who performed exercise countermeasures. The purpose of this study was to compare performance during the Tandem Walk test between bed rest subjects (with and without exercise), short-duration (Space Shuttle) crewmembers, and long-duration International Space Station (ISS) crewmembers at various time points during their recovery from bed rest or spaceflight.

  15. Experimental verification of optically optimized CuGaSe2 top cell for improving chalcopyrite tandems

    Science.gov (United States)

    Schmid, M.; Caballero, R.; Klenk, R.; Krč, J.; Rissom, T.; Topi, M.; Lux-Steiner, M. Ch.

    2010-07-01

    An efficient tandem solar cell requires a top cell which is highly transparent below the energy gap of its absorber. Previously we had reported on a theoretically optimized CuGaSe2top cell stack based on realistic material properties. It promised a significant increase in optical transparency and, consequently, enhanced CuGaSe2/Cu(In,Ga)Se2tandem efficiency. Here we present the first steps taken towards the experimental realization of this optimized tandem. We started with a mechanically stacked device which achieved 8.5% efficiency. Optical measurements of the improved top cells and corresponding photo current densities of the filtered bottom cell are reported. The experimental findings are in agreement with the optical modeling. These data are used to assess the level of tandem performance that could be accomplished in the near future and to discuss the priorities of further research. This article has been previously published in PV Direct, the former name of EPJ Photovoltaics.

  16. Sensitive, Preclinical Detection of Prions in Brain by nanospray liquid chromatography/tandem mass spectrometry

    Science.gov (United States)

    More sensitive detection of prions in brain is important because it would allow early detection of disease in young animals and assure a safer food supply. We quantitated the amount of proteinase K-resistant prion protein (PrP 27-30) by use of nano-scale liquid chromatography coupled to a tandem ma...

  17. Synthesis of substituted pyrazoles via tandem cross-coupling/electrocyclization of enol triflates and diazoacetates.

    Science.gov (United States)

    Babinski, David J; Aguilar, Hector R; Still, Raymond; Frantz, Doug E

    2011-08-05

    The synthesis of 3,4,5-trisubstituted pyrazoles via a tandem catalytic cross-coupling/electrocyclization of enol triflates and diazoacetates is presented. The initial scope of this methodology is demonstrated on a range of differentially substituted acyclic and cyclic enol triflates as well as an elaborated set of diazoacetates to provide the corresponding pyrazoles with a high degree of structural complexity.

  18. Improved electroabsorption demultiplexer by tandem-arrangement with semiconductor optical amplifier

    DEFF Research Database (Denmark)

    Hilliger, E.; Marembert, V.; Schubert, C.

    2002-01-01

    An electroabsorption demultiplexer was improved by operating it in a tandem-arrangement with an optically controlled SOA. An increase of the maximum data rate from 40 Gbit/s to 80 Gbit/s was experimentally demonstrated. The main drawback of the proposed scheme is the need of an additional optical...

  19. A new, analysis-based, change of measure for tandem queues

    NARCIS (Netherlands)

    Boer, de Pieter-Tjerk; Scheinhardt, Werner R.W.

    2010-01-01

    In this paper, we introduce a simple analytical approximation for the overflow probability of a two-node tandem queue. From this, we derive a change of measure, which turns out to have good performance in almost the entire parameter space. The form of our new change of measure sheds an interesting n

  20. High work function transparent middle electrode for organic tandem solar cells

    NARCIS (Netherlands)

    Moet, D. J. D.; de Bruyn, P.; Blom, P. W. M.

    2010-01-01

    The use of poly(3,4-ethylenedioxythiophene) poly(styrenesulfonate) (PEDOT:PSS) in combination with ZnO as middle electrode in solution-processed organic tandem solar cells requires a pH modification of the PEDOT:PSS dispersion. We demonstrate that this neutralization leads to a reduced work function

  1. Language Learning Shifts and Attitudes towards Language Learning in an Online Tandem Program for Beginner Writers

    Science.gov (United States)

    Tolosa, Constanza; Ordóñez, Claudia Lucía; Guevara, Diana Carolina

    2017-01-01

    We present findings of a project that investigated the potential of an online tandem program to enhance the foreign language learning of two groups of school-aged beginner learners, one learning English in Colombia and the other learning Spanish in New Zealand. We assessed the impact of the project on students' learning with a free writing…

  2. Bait type influences on catch and bycatch in tandem hoop nets set in reservoirs

    Science.gov (United States)

    Long, James M.; Stewart, David R.; Shiflet, Jeremy; Balsman, Dane; Shoup, Daniel E.

    2017-01-01

    Tandem hoop nets have become the primary gear for sampling channel catfish Ictalurus punctatus, but suffer from high incidences of bycatch, particularly aquatic turtles that usually drown as a result. We sought to determine if bait type, ZOTE© soap and ground cheese logs, would influence catch of channel catfish (CPUE and mean TL) and bycatch of fishes and aquatic turtles. We sampled with tandem hoop nets in 13 Kentucky reservoirs (5–73 ha) using a crossover design and two sampling events. We found no difference in channel catfish catch rates between bait types, but mean sizes of fish caught using ZOTE© soap were approximately 24 mm longer compared to cheese. Fish bycatch was similar between bait types, but tandem hoop nets baited with ZOTE© soap caught up to 61% fewer turtles and mortality of turtles that were captured was up to 12% lower than those baited with cheese. Depth of net set, water temperature, and Secchi depth were environmental factors measured that affected catch and bycatch, but varied among species. Using ZOTE© soap as bait in tandem hoop nets appears to be a fairly simple and straightforward method for maintaining high catch rates of channel catfish while minimizing turtle mortality.

  3. JAERI TANDEM and V.D.G. annual report 1996. April 1, 1996 - March 31, 1997

    Energy Technology Data Exchange (ETDEWEB)

    Takeuchi, Suehiro; Ikezoe, Hiroshi; Iwamoto, Akira; Sataka, Masao; Nagame, Yuichiro; Shoji, Tokio; Okabe, Takashi; Maekawa, Hiroshi [eds.] [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    1997-09-01

    This annual report describes research activities which have been performed with the JAERI tandem accelerator and the Van de Graaf accelerator from April 1, 1996 to March 31, 1997. Summary reports of 48 papers, and list of publications, personnel and cooperative researches with universities are contained. (author)

  4. Rare-event simulation for tandem queues: A simple and efficient importance sampling scheme

    NARCIS (Netherlands)

    Miretskiy, D.; Scheinhardt, W.; Mandjes, M.

    2009-01-01

    This paper focuses on estimating the rare event of overflow in the downstream queue of a tandem Jackson queue, relying on importance sampling. It is known that in this setting ‘traditional’ state-independent schemes perform poorly. More sophisticated state-dependent schemes yield asymptotic efficien

  5. Toward Male Individualization with Rapidly Mutating Y-Chromosomal Short Tandem Repeats

    NARCIS (Netherlands)

    K. Ballantyne (Kaye); A. Ralf (Arwin); R. Aboukhalid (Rachid); N.M. Achakzai (Niaz); T. Anjos (Tania); Q. Ayub (Qasim); J. Balažic (Jože); J. Ballantyne (Jack); D.J. Ballard (David); B. Berger (Burkhard); C. Bobillo (Cecilia); M. Bouabdellah (Mehdi); H. Burri (Helen); T. Capal (Tomas); S. Caratti (Stefano); J. Cárdenas (Jorge); F. Cartault (François); E.F. Carvalho (Elizeu); M. de Carvalho (Margarete); B. Cheng (Baowen); M.D. Coble (Michael); D. Comas (David); D. Corach (Daniel); M. D'Amato (Mauro); S. Davison (Sean); P. de Knijff (Peter); M.C.A. de Ungria (Maria Corazon); R. Decorte (Ronny); T. Dobosz (Tadeusz); B.M. Dupuy (Berit); S. Elmrghni (Samir); M. Gliwiński (Mateusz); S.C. Gomes (Sara); L. Grol (Laurens); C. Haas (Cordula); E. Hanson (Erin); J. Henke (Jürgen); L. Henke (Lotte); F. Herrera-Rodríguez (Fabiola); C.R. Hill (Carolyn); G. Holmlund (Gunilla); K. Honda (Katsuya); U.-D. Immel (Uta-Dorothee); S. Inokuchi (Shota); R. Jobling; M. Kaddura (Mahmoud); J.S. Kim (Jong); S.H. Kim (Soon); W. Kim (Wook); T.E. King (Turi); E. Klausriegler (Eva); D. Kling (Daniel); L. Kovačević (Lejla); L. Kovatsi (Leda); P. Krajewski (Paweł); S. Kravchenko (Sergey); M.H.D. Larmuseau (Maarten); E.Y. Lee (Eun Young); R. Lessig (Rüdiger); L.A. Livshits (Ludmila); D. Marjanović (Damir); M. Minarik (Marek); N. Mizuno (Natsuko); H. Moreira (Helena); N. Morling (Niels); M. Mukherjee (Meeta); P. Munier (Patrick); J. Nagaraju (Javaregowda); F. Neuhuber (Franz); S. Nie (Shengjie); P. Nilasitsataporn (Premlaphat); T. Nishi (Takeki); H.H. Oh (Hye); S. Olofsson (Sylvia); V. Onofri (Valerio); J. Palo (Jukka); H. Pamjav (Horolma); W. Parson (Walther); M. Petlach (Michal); C. Phillips (Christopher); R. Ploski (Rafal); S.P.R. Prasad (Samayamantri P.); D. Primorac (Dragan); G.A. Purnomo (Gludhug); J. Purps (Josephine); H. Rangel-Villalobos (Hector); K. Reogonekbała (Krzysztof); B. Rerkamnuaychoke (Budsaba); D.R. Gonzalez (Danel Rey); C. Robino (Carlo); L. Roewer (Lutz); A. de Rosa (Anna); A. Sajantila (Antti); A. Sala (Andrea); J.M. Salvador (Jazelyn); P. Sanz (Paula); C. Schmitt (Christian); A.K. Sharma (Anisha K.); D.A. Silva (Dayse); K.-J. Shin (Kyoung-Jin); T. Sijen (Titia); M. Sirker (Miriam); D. Siváková (Daniela); V. Škaro (Vedrana); C. Solano-Matamoros (Carlos); L. Souto (L.); V. Stenzl (Vlastimil); H. Sudoyo (Herawati); D. Syndercombe-Court (Denise); A. Tagliabracci (Adriano); D. Taylor (Duncan); A. Tillmar (Andreas); I.S. Tsybovsky (Iosif); C. Tyler-Smith (Chris); K. van der Gaag (Kristiaan); D. Vanek (Daniel); A. Völgyi (Antónia); D. Ward (Denise); P. Willemse (Patricia); E.P.H. Yap (Eric); Z-Y. Yong (Ze-Yie); I.Z. Pajnič (Irena Zupanič); M.H. Kayser (Manfred)

    2014-01-01

    textabstractRelevant for various areas of human genetics, Y-chromosomal short tandem repeats (Y-STRs) are commonly used for testing close paternal relationships among individuals and populations, and for male lineage identification. However, even the widely used 17-loci Yfiler set cannot resolve

  6. Synthesis of Quinoxaline Derivatives via Tandem Oxidative Azidation/Cyclization Reaction of N-Arylenamines.

    Science.gov (United States)

    Ma, Haichao; Li, Dianjun; Yu, Wei

    2016-02-19

    A new method was developed for the synthesis of quinoxalines. This method employs N-arylenamines and TMSN3 as the starting materials and implements two oxidative C-N bond-forming processes in a tandem pattern by using (diacetoxyiodo)benzene as the common oxidant. The present reaction conditions are mild and simple and thus are useful in practical synthesis.

  7. Determination of folic acid in human plasma using hydrophilic interaction chromatography-tandem mass spectrometry

    NARCIS (Netherlands)

    Garbis, S.D.; Melse-Boonstra, A.; West, C.E.; Breemen, van R.B.

    2001-01-01

    Folic acid is an essential nutrient, and folate deficiency is associated with a variety of disorders including neural tube defects (during pregnancy) and heart disease. A fast, sensitive, and robust HPLC-tandem mass spectrometry (LC-MS-MS) method was developed for the quantification of free folic ac

  8. Tandem affinity purification of functional TAP-tagged proteins from human cells

    NARCIS (Netherlands)

    Gregan, Juraj; Riedel, Christian G; Petronczki, Mark; Cipak, Lubos; Rumpf, Cornelia; Poser, Ina; Buchholz, Frank; Mechtler, Karl; Nasmyth, Kim

    2007-01-01

    Tandem affinity purification (TAP) is a generic two-step affinity purification protocol for isolation of TAP-tagged proteins together with associated proteins. We used bacterial artificial chromosome to heterologously express TAP-tagged murine Sgo1 protein in human HeLa cells. This allowed us to tes

  9. Analysis of the Aconitine Alkaloids in Chuanwu by Electrospray Ionization/Tandem Mass Spectrometry

    Institute of Scientific and Technical Information of China (English)

    Ai Min SUN; Hui LI; Zhi Ming HUANG; P.P.H.BUT; Xue Qin DING

    2004-01-01

    An electrospray ionization / tandem mass spectrometric (ESI/MS/MS) method was developed for the simultaneous identification and analysis of three aconitine alkaloids [ mesacontine (MA), hypaconitine (HA), and aconitine (A)] as intact molecules at low nanogram level in Chinese traditional medicine Chuanwu decoction as well as in human whole blood extract without chromatographic separation.

  10. Genome-wide analysis of tandem repeats in plants and green algae

    Science.gov (United States)

    Zhixin Zhao; Cheng Guo; Sreeskandarajan Sutharzan; Pei Li; Craig Echt; Jie Zhang; Chun Liang

    2014-01-01

    Tandem repeats (TRs) extensively exist in the genomes of prokaryotes and eukaryotes. Based on the sequenced genomes and gene annotations of 31 plant and algal species in Phytozome version 8.0 (http://www.phytozome.net/), we examined TRs in a genome-wide scale, characterized their distributions and motif features, and explored their putative biological functions. Among...

  11. Turkish population data with the CODIS multiplex short tandem repeat loci.

    Science.gov (United States)

    Akbasak, B S; Budowle, B; Reeder, D J; Redman, J; Kline, M C

    2001-12-01

    Allele frequencies for 13 tetrameric short tandem repeat (STR) loci, CSF1PO, D18S51, D3S1358, D21S11, D5S818, FGA, D7S820, HUMTH01, D8S1179, TPOX, D13S317, VWA, and D16S539 were determined on 198 Turkish blood samples.

  12. Materials science symposium 'heavy ion science in tandem energy region'

    Energy Technology Data Exchange (ETDEWEB)

    Iwamoto, Akira; Yoshida, Tadashi; Takeuchi, Suehiro [eds.

    2000-01-01

    The tandem accelerator established at Japan Atomic Energy Research Institute (JAERI) in 1982 has been one of the most prominent electrostatic accelerators in the world. The accelerator has been serving for many researches planned by not only JAERI staff but also researchers of universities and national institutes. After the completion of the tandem booster in 1993, four times higher beam energy became available. These two facilities, the tandem accelerator and the booster, made great strides in heavy ion physics and a lot of achievements have been accumulated until now. The research departments of JAERI were reformed in 1998, and the accelerators section came under the Department of Materials Science. On this reform of the research system, the symposium 'Heavy Ion Science in Tandem Energy Region' was held in cooperation with nuclear and solid state physicists although there has been no such symposium for many years. The symposium was expected to stimulate novel development in both nuclear and solid state physics, and also interdisciplinary physics between nuclear and solid state physics. The 68 papers are indexed individually. (J.P.N.)

  13. JAERI tandem annual report 2001. April 1, 2001 - March 31, 2002

    Energy Technology Data Exchange (ETDEWEB)

    Takeuchi, Suehiro; Ikezoe, Hiroshi; Chiba, Satoshi; Nagame, Yuichiro; Sataka, Masao; Iwamoto, Akira (eds.) [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    2002-11-01

    This annual report describes research activities which have been performed with the JAERI tandem accelerator and the Van de Graaff accelerator from April 1, 2001 to March 31, 2002. Summary reports of 48 papers, and lists of publication, personnel and cooperative research with universities are contained. (author)

  14. Development of a tandem repeat-based multilocus typing system distinguishing Babesia bovis geographic isolates

    Science.gov (United States)

    Mini and microsatellite sequences have proven to be excellent tools for the differentiation of strains and populations in several protozoan parasites due to their high variability. In the present work we have searched the genome of the tick-transmitted bovine hemoprotozoon Babesia bovis for tandem r...

  15. Differentiating samples and experimental protocols by direct comparison of tandem mass spectra

    NARCIS (Netherlands)

    Plas-Duivesteijn, Van Der Suzanne J.; Wulff, Tune; Klychnikov, Oleg; Keijzer, De Jeroen; Nessen, Merel A.

    2016-01-01

    Rationale Peptide tandem mass spectra can be analyzed by a number of means. They can be compared against predicted spectra of peptides derived from genome sequences, compared against previously acquired and identified spectra, or - sometimes - sequenced de novo. We recently introduced another met

  16. Assisted Tandem Catalysis : Metathesis Followed by Asymmetric Hydrogenation from a Single Ruthenium Source

    NARCIS (Netherlands)

    Renom-Carrasco, Marc; Gajewski, Piotr; Pignataro, Luca; de Vries, Johannes G.; Piarulli, Umberto; Gennari, Cesare; Lefort, Laurent

    2015-01-01

    Here we report the first example of a tandem metathesis-asymmetric hydrogenation protocol where the prochiral olefin generated by metathesis is hydrogenated with high enantioselectivity by an in situ formed chiral ruthenium catalyst. We show that either the ruthenium metathesis catalysts or the ruth

  17. Control of PHERES1 Imprinting in Arabidopsis by Direct Tandem Repeats

    Institute of Scientific and Technical Information of China (English)

    Corina Belle R.Villar; Aleksandra Erilova; Grigory Makarevich; Raphael Tr(o)sch; Claudia K(o)hler

    2009-01-01

    Genomic imprinting is an epigenetic phenomenon that causes monoallelic expression of specific genes dependent on the parent-of-origin.Imprinting of the Arabiclopsis gene PHERES1 requires the function of the FERTILIZATION INDEPENDENT SEED (FIS) Polycomb group complex as well as a distally located methylated region containing a tandem triple repeat sequence.In this study,we investigated the regulation of the close PHERES1 homolog PHERES2.We found that PHERES2 is also a direct target gene of the FIS Polycomb group complex,but,in contrast to PHERES1,PHERES2 is equally expressed from maternal and paternal alleles.Thus,PHERES2 is not regulated by genomic imprinting,correlating with the lack of tandem repeats at PHERES2.Eliminating tandem repeats from the PHERES1 locus abolishes PHERES1 imprinting,demonstrating that tandem repeats are essential for PHERES1 imprinting.Taking these results together,our study shows that the recently duplicated genes PHERES1 and PHERES2 are both target genes of the FIS Polycomb group complex but only PHERES1 is regulated by genomic imprinting,which is likely caused by the presence of repeat sequences in the proximity of the PHERES1 locus.

  18. Simulation of a Jackson tandem network using state-dependent importance sampling

    NARCIS (Netherlands)

    Miretskiy, D.I.; Scheinhardt, W.R.W.; Mandjes, M.R.H.

    2008-01-01

    This paper considers importance sampling as a tool for rareevent simulation. The focus is on estimating the probability of overflow in the downstream queue of a Jackson twonode tandem queue. It is known that in this setting ‘traditional’ state-independent importance-sampling distributions perform po

  19. RUTHENIUM-CATALYZED TANDEM OLEFIN MIGRATION-ALDOL AND MANNICH-TYPE REACTIONS IN IONIC LIQUID.

    Science.gov (United States)

    In the presence of a catalytic amount of RuCl2(PPh3)3, a cross-coupling of 3-buten-2-ol with aldehydes and imines was developed via a tandem olefin migration--aldol--Mannich reaction in bmim[PF6]. With In(OAc)3 as a co-catalyst, a-vinylbenzyl alcohol and aldehydes underwent sim...

  20. JAERI TANDEM and V.D.G. annual report 1994. April 1, 1994 - March 31, 1995

    Energy Technology Data Exchange (ETDEWEB)

    Suzuki, Yasuo; Ikezoe, Hiroshi; Iwamoto, Akira; Sataka, Masao; Shinohara, Nobuo; Takeuchi, Suehiro; Shoji, Tokio; Okabe, Takashi [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment] [eds.

    1995-10-01

    This annual report describes research activities which have been performed with the JAERI tandem accelerator and the Van de Graaff accelerator from April 1, 1994 to March 31, 1995. Summary reports of 47 papers, and list of publications, personnel and cooperative researches with universities are contained. (author).

  1. JAERI TANDEM and V.D.G. annual report 1995. April 1, 1995 - March 31, 1996

    Energy Technology Data Exchange (ETDEWEB)

    Takeuchi, Suehiro; Ikezoe, Hiroshi; Iwamoto, Akira; Sataka, Masao; Nagame, Yuichiro; Shoji, Tokio; Okabe, Takashi; Maekawa, Hiroshi [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment] [eds.

    1996-08-01

    This annual report describes research activities which have been performed with the JAERI Tandem accelerator and the Van de Graaff accelerator from April 1, 1995 to March 31, 1996. Summary reports of 59 papers, and list of publications, personnel and cooperative researches with universities are contained. (author)

  2. Specific tandem repeats are sufficient for paramutation-induced trans-generational silencing

    NARCIS (Netherlands)

    Belele, C.L.; Sidorenko, L.; Stam, M.; Bader, R.; Arteaga-Vazquez, M.A.; Chandler, V.L.

    2013-01-01

    Paramutation is a well-studied epigenetic phenomenon in which trans communication between two different alleles leads to meiotically heritable transcriptional silencing of one of the alleles. Paramutation at the b1 locus involves RNA-mediated transcriptional silencing and requires specific tandem re

  3. Liquid chromatographic-tandem mass spectrometric determination of selected sulphonamides in milk

    NARCIS (Netherlands)

    Rhijn, van J.A.; Lasaroms, J.J.P.; Berendsen, B.J.A.; Brinkman, U.A.Th.

    2002-01-01

    Liquid chromatography–tandem mass spectrometry is used for the quantitative analysis of selected sulphonamides in milk. Ultrafiltration is the only sample pre-treatment technique which is required. Consequently, sample throughput is much higher than with conventional procedures, and analyte recoveri

  4. Learner Perspectives on Task Design for Oral-Visual eTandem Language Learning

    Science.gov (United States)

    El-Hariri, Yasmin

    2016-01-01

    Constituting a more specific form of online collaboration, eTandem Language Learning (eTLL) shows great potential for non-formal, self-directed language learning. Research in this field, particularly regarding task design, is still scarce. Focusing on their beliefs and attitudes, this article examines what learners think about how…

  5. JAERI tandem and V.D.G. annual report 1997. April 1, 1997 - March 31, 1998

    Energy Technology Data Exchange (ETDEWEB)

    Takeuchi, Suehiro; Ikezoe, Hiroshi; Chiba, Satoshi; Sataka, Masao; Nagame, Yuichiro; Takemori, Satoshi; Iwamoto, Akira [eds.] [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    1998-10-01

    This annual report describes research activities which have been performed with the JAERI tandem accelerator and the Van de Graaff accelerator from April 1, 1997 to March 31, 1998. Summary reports of 40 papers, and lists of publication, personnel and cooperative researches with universities are contained. (author)

  6. JAERI tandem and V.D.G. annual report 1998. April 1, 1998 - March 31, 1999

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-12-01

    This annual report describes research activities which have been performed with the JAERI tandem accelerator and the Van de Graaff accelerator from April 1, 1998 to March 31, 1999. Summary reports of 38 papers, and lists of publication, personnel and cooperative research with universities and contained. (author)

  7. Large-scale analysis of tandem repeat variability in the human genome.

    Science.gov (United States)

    Duitama, Jorge; Zablotskaya, Alena; Gemayel, Rita; Jansen, An; Belet, Stefanie; Vermeesch, Joris R; Verstrepen, Kevin J; Froyen, Guy

    2014-05-01

    Tandem repeats are short DNA sequences that are repeated head-to-tail with a propensity to be variable. They constitute a significant proportion of the human genome, also occurring within coding and regulatory regions. Variation in these repeats can alter the function and/or expression of genes allowing organisms to swiftly adapt to novel environments. Importantly, some repeat expansions have also been linked to certain neurodegenerative diseases. Therefore, accurate sequencing of tandem repeats could contribute to our understanding of common phenotypic variability and might uncover missing genetic factors in idiopathic clinical conditions. However, despite long-standing evidence for the functional role of repeats, they are largely ignored because of technical limitations in sequencing, mapping and typing. Here, we report on a novel capture technique and data filtering protocol that allowed simultaneous sequencing of thousands of tandem repeats in the human genomes of a three generation family using GS-FLX-plus Titanium technology. Our results demonstrated that up to 7.6% of tandem repeats in this family (4% in coding sequences) differ from the reference sequence, and identified a de novo variation in the family tree. The method opens new routes to look at this underappreciated type of genetic variability, including the identification of novel disease-related repeats.

  8. Micromorph tandem solar cells: optimization of the microcrystalline silicon bottom cell in a single chamber system

    Institute of Scientific and Technical Information of China (English)

    Zhang Xiao-Dan; Zheng Xin-Xia; Xu Sheng-Zhi; Lin Quan; Wei Chang-Chun; Sun Jian; Geng Xin-Hua; Zhao Ying

    2011-01-01

    We report on the development of single chamber deposition of microcrystalline and micromorph tandem solar cells directly onto low-cost glass substrates.The cells have pin single-junction or pin/pin double-junction structures on glass substrates coated with a transparent conductive oxide layer such as SnO2 or ZnO.By controlling boron and phosphorus contaminations,a single-junction microcrystalline silicon cell with a conversion efficiency of 7.47% is achieved with an i-layer thickness of 1.2 μm.In tandem devices,by thickness optimization of the microcrystalline silicon bottom solar cell,we obtained an initial conversion efficiency of 9.91% with an aluminum (Al) back reflector without a dielectric layer.In order to enhance the performance of the tandem solar cells,an improved light trapping structure with a ZnO/Al back reflector is used.As a result,a tandem solar cell with 11.04% of initial conversion efficiency has been obtained.

  9. PIV and pressure measurements on two high-rise models in tandem arrangement

    NARCIS (Netherlands)

    Bronkhorst, A.J.; Bentum, C.A. van; Geurts, C.P.W.; Jong, A. de

    2012-01-01

    Particle Image Velocimetry (PIV) and pressure measurements were performed on a highrise model with a height (H) of 0.48 m and a width (B) of 0.12 m in a turbulent atmospheric boundary layer. Experiments were carried out for an isolated model and four tandem configurations with varying separation dis

  10. Identification of hydroxylcinnamoyl tartaric acid esters in Bidens pilosa by UPLC-tandem mass spectrometry

    CSIR Research Space (South Africa)

    Khoza, BS

    2016-03-01

    Full Text Available of Botany, vol. 103: 95-100 Identification of hydroxylcinnamoyl tartaric acid esters in Bidens pilosa by UPLC-tandem mass spectrometry Khoza BS Gbashi S Steenkamp PA Njobe PB Madala NE ABSTRACT: Bidens pilosa is a medicinal plant used...

  11. Determination of folic acid in human plasma using hydrophilic interaction chromatography-tandem mass spectrometry

    NARCIS (Netherlands)

    Garbis, S.D.; Melse-Boonstra, A.; West, C.E.; Breemen, van R.B.

    2001-01-01

    Folic acid is an essential nutrient, and folate deficiency is associated with a variety of disorders including neural tube defects (during pregnancy) and heart disease. A fast, sensitive, and robust HPLC-tandem mass spectrometry (LC-MS-MS) method was developed for the quantification of free folic

  12. High work function transparent middle electrode for organic tandem solar cells

    NARCIS (Netherlands)

    Moet, D. J. D.; de Bruyn, P.; Blom, P. W. M.

    2010-01-01

    The use of poly(3,4-ethylenedioxythiophene) poly(styrenesulfonate) (PEDOT:PSS) in combination with ZnO as middle electrode in solution-processed organic tandem solar cells requires a pH modification of the PEDOT:PSS dispersion. We demonstrate that this neutralization leads to a reduced work function

  13. Toward Male Individualization with Rapidly Mutating Y-Chromosomal Short Tandem Repeats

    NARCIS (Netherlands)

    K. Ballantyne (Kaye); A. Ralf (Arwin); R. Aboukhalid (Rachid); N.M. Achakzai (Niaz); T. Anjos (Tania); Q. Ayub (Qasim); J. Balažic (Jože); J. Ballantyne (Jack); D.J. Ballard (David); B. Berger (Burkhard); C. Bobillo (Cecilia); M. Bouabdellah (Mehdi); H. Burri (Helen); T. Capal (Tomas); S. Caratti (Stefano); J. Cárdenas (Jorge); F. Cartault (François); E.F. Carvalho (Elizeu); M. de Carvalho (Margarete); B. Cheng (Baowen); M.D. Coble (Michael); D. Comas (David); D. Corach (Daniel); M. D'Amato (Mauro); S. Davison (Sean); P. de Knijff (Peter); M.C.A. de Ungria (Maria Corazon); R. Decorte (Ronny); T. Dobosz (Tadeusz); B.M. Dupuy (Berit); S. Elmrghni (Samir); M. Gliwiński (Mateusz); S.C. Gomes (Sara); L. Grol (Laurens); C. Haas (Cordula); E. Hanson (Erin); J. Henke (Jürgen); L. Henke (Lotte); F. Herrera-Rodríguez (Fabiola); C.R. Hill (Carolyn); G. Holmlund (Gunilla); K. Honda (Katsuya); U.-D. Immel (Uta-Dorothee); S. Inokuchi (Shota); R. Jobling; M. Kaddura (Mahmoud); J.S. Kim (Jong); S.H. Kim (Soon); W. Kim (Wook); T.E. King (Turi); E. Klausriegler (Eva); D. Kling (Daniel); L. Kovačević (Lejla); L. Kovatsi (Leda); P. Krajewski (Paweł); S. Kravchenko (Sergey); M.H.D. Larmuseau (Maarten); E.Y. Lee (Eun Young); R. Lessig (Rüdiger); L.A. Livshits (Ludmila); D. Marjanović (Damir); M. Minarik (Marek); N. Mizuno (Natsuko); H. Moreira (Helena); N. Morling (Niels); M. Mukherjee (Meeta); P. Munier (Patrick); J. Nagaraju (Javaregowda); F. Neuhuber (Franz); S. Nie (Shengjie); P. Nilasitsataporn (Premlaphat); T. Nishi (Takeki); H.H. Oh (Hye); S. Olofsson (Sylvia); V. Onofri (Valerio); J. Palo (Jukka); H. Pamjav (Horolma); W. Parson (Walther); M. Petlach (Michal); C. Phillips (Christopher); R. Ploski (Rafal); S.P.R. Prasad (Samayamantri P.); D. Primorac (Dragan); G.A. Purnomo (Gludhug); J. Purps (Josephine); H. Rangel-Villalobos (Hector); K. Reogonekbała (Krzysztof); B. Rerkamnuaychoke (Budsaba); D.R. Gonzalez (Danel Rey); C. Robino (Carlo); L. Roewer (Lutz); A. de Rosa (Anna); A. Sajantila (Antti); A. Sala (Andrea); J.M. Salvador (Jazelyn); P. Sanz (Paula); C. Schmitt (Christian); A.K. Sharma (Anisha K.); D.A. Silva (Dayse); K.-J. Shin (Kyoung-Jin); T. Sijen (Titia); M. Sirker (Miriam); D. Siváková (Daniela); V. Škaro (Vedrana); C. Solano-Matamoros (Carlos); L. Souto (L.); V. Stenzl (Vlastimil); H. Sudoyo (Herawati); D. Syndercombe-Court (Denise); A. Tagliabracci (Adriano); D. Taylor (Duncan); A. Tillmar (Andreas); I.S. Tsybovsky (Iosif); C. Tyler-Smith (Chris); K. van der Gaag (Kristiaan); D. Vanek (Daniel); A. Völgyi (Antónia); D. Ward (Denise); P. Willemse (Patricia); E.P.H. Yap (Eric); Z-Y. Yong (Ze-Yie); I.Z. Pajnič (Irena Zupanič); M.H. Kayser (Manfred)

    2014-01-01

    textabstractRelevant for various areas of human genetics, Y-chromosomal short tandem repeats (Y-STRs) are commonly used for testing close paternal relationships among individuals and populations, and for male lineage identification. However, even the widely used 17-loci Yfiler set cannot resolve ind

  14. Simulation of a Jackson tandem network using state-dependent importance sampling

    NARCIS (Netherlands)

    Miretskiy, D.I.; Scheinhardt, W.R.W.; Mandjes, M.R.H.

    2008-01-01

    This paper considers importance sampling as a tool for rare-event simulation. The focus is on estimating the probability of overflow in the downstream queue of a Jackson two-node tandem queue. It is known that in this setting `traditional' state-independent importance-sampling distributions perform

  15. Proceedings of the 13th meeting for tandem accelerators and related techniques

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-02-01

    The 13th Meeting for Tandem Accelerators and Related Techniques was held on June 8-9, 2000 at Mutsu, Aomori Prefecture, under the auspices of Marine Research Laboratory, Mutsu Establishment, the Japan Atomic Energy Research Institute. About 60 people participated in the meeting from 27 universities and organizations, many of which have a tandem accelerator or an electrostatic accelerator. The objectives of the meeting are to exchange information on tandem accelerates or electrostatic accelerators by making a presentation on related research and topics, and also to enhance mutual friendship of participants, resulting in the contribution to associated R and D. The meeting mainly consisted of presentations by participants and corresponding Q and A; the present situation on facilities of accelerator mass spectrometers (AMS), operations of and research on tandem accelerators or electrostatic accelerators, applications of AMS, related techniques and applications using accelerators, and so on. This report summarizes the contents of presentations made in the meeting. The 30 of the presented papers are indexed individually. (J.P.N.)

  16. Multiresidue analysis of pesticides in straw roughage by liquid chromatography - tandem mass spectrometry

    Science.gov (United States)

    A multiresidue analytical method using a modification of the “quick, easy, cheap, effective, rugged, and safe” (QuEChERS) sample preparation approach combined with liquid chromatography–tandem mass spectrometry (LC-MS/MS) analysis was established and validated for the rapid determination of 69 pesti...

  17. GPU accelerated tandem traversal of blocked bounding volume hierarchy collision detection for multibody dynamics

    DEFF Research Database (Denmark)

    Damkjær, Jesper; Erleben, Kenny

    2009-01-01

    hierarchies. Our approach makes it possible to perform non-convex object versus non-convex object collision on the GPU, using tandem traversals of bounding volume hierarchies. Prior work only supports single traversals on GPUs. We introduce a blocked hierarchy data structure, using imaginary nodes...

  18. Sample-Path Optimization of Buffer Allocations in a Tandem Queue - Part I : Theoretical Issues

    NARCIS (Netherlands)

    Gürkan, G.; Ozge, A.Y.

    1996-01-01

    This is the first of two papers dealing with the optimal bu er allocation problem in tandem manufacturing lines with unreliable machines.We address the theoretical issues that arise when using sample-path optimization, a simulation-based optimization method, to solve this problem.Sample-path optimiz

  19. Self-sustained oscillations between two tandem cylinders at Reynolds number 1,000

    Energy Technology Data Exchange (ETDEWEB)

    Kuo, C.H.; Chein, S.M.; Hsieh, H.J. [National Chung Hsing University, Department of Mechanical Engineering, Taichung (China)

    2008-04-15

    This study focuses on the self-sustained oscillatory flow characteristics between two tandem circular cylinders of equal diameter placed in a uniform inflow. The Reynolds number (Re{sub D}), based on the cylinder diameter, was around 1,000 and all experiments were performed in a recirculating water channel. The streamwise distance between two tandem cylinders ranged within 1.5 {<=} X{sub c}/D {<=} 7.0. Here X{sub c} denotes the center-to-center distance between two tandem cylinders. For all experiments studied herein, quantitative velocity measurements were performed using hot-film anemometer and the LDV system. The laser sheet technique was employed for qualitative flow visualization. The wavelet transform was applied to elucidate the temporal variation and phase difference between two spectral components of the velocity signals detected in the flow field. The remarkable finding was that when two tandem circular cylinders were spaced at a distance within 4.5 {<=} X{sub c}/D {<=} 5.5, two symmetrical unstable shear layers with a certain wavelength were observed to impinge onto the downstream cylinder. The responding frequency (f{sub u}), measured between these two cylinders, was much higher than the natural shedding frequency behind a single isolated cylinder at the same Re{sub D}. This responding frequency decreased as the distance X{sub c}/D increased. Not until X{sub c}/D {>=} 6.0, did it recover to the natural shedding frequency behind a single isolated cylinder. Between two tandem cylinders, the Strouhal numbers (St{sub c} = f{sub u} X{sub c}/U{sub c}) maintained a nearly constant value of 3, indicating the self-sustained oscillating flow characteristics with a wavelength X{sub c}/3. Here U{sub c} is the convection speed of the unstable shear layers between two tandem cylinders. At Re{sub D} = 1,000, the self-sustained oscillating characteristics between two tandem circular cylinders were proven to exhibit a sustained flow pattern, not just a sporadic

  20. Combined heat and power plants with parallel tandem steam turbines; Smaaskalig kraftvaerme med parallellkopplade tandemturbiner

    Energy Technology Data Exchange (ETDEWEB)

    Steinwall, Pontus; Norstroem, Urban; Pettersson, Camilla; Oesterlin, Erik

    2004-12-01

    We investigate the technical and economical conditions for a concept with parallel coupled tandem turbines in small scale combined heat and power plants fired with bio-fuel and waste. Performance and heat production costs at varying electricity prices for the concept with two smaller tandem coupled steam turbines has been compared to the traditional concept with one single multi-staged turbine. Three different types of plants have been investigated: - Bio fuelled CHP plant with thermal capacity of 15 MW{sub th}; - Waste fired CHP plant with thermal capacity of 20 MW{sub th}; - Bio fuelled CHP plant with thermal capacity of 25 MW{sub th}. The simple steam turbines (Curtis turbines) used in the tandem arrangement has an isentropic efficiency of about 49 to 53% compared to the multi-staged steam turbines with isentropic efficiency in the range of 59% to 81%. The lower isentropic efficiency for the single staged turbines is to some extent compensated at partial load when one of the two turbines can be shut down leading to better operational conditions for the one still in operation. For concepts with saturated steam at partial load below 50% the tandem arrangements presents higher electricity efficiency than the conventional single turbine alternative. The difference in annual production of electricity is therefore less than the difference in isentropic efficiency for the two concepts. Production of electricity is between 2% and 42% lower for the tandem arrangements in this study. Investment costs for the turbine island has been calculated for the two turbine concepts and when the costs for turbines, generator, power transmission, condensing system, piping system, buildings, assembling, commissioning and engineering has been added the sum is about the same for the two concepts. For the bio-fuelled plant with thermal capacity of 15 MW{sub th} the turbine island amount to about 10-12 MSEK and about 13-15 MSEK for the waste fired plant with a thermal capacity of 20 MW

  1. Balance in essential tremor during tandem gait: is the first mis-step an important finding?

    Science.gov (United States)

    Cinar, N; Sahin, S; Okluoglu Onay, T; Karsidag, S

    2013-10-01

    Essential tremor (ET) is the most commonly diagnosed movement disorder. ET may cause substantial loss of motor skills and balance with advanced age. We compared abnormalities in tandem gait with daily activity and Fahn-Tolosa-Marin Tremor Rating Scale (FTMTRS) scores in 90 ET patients. All patients performed a 15-step tandem three times. The mean of first mis-steps was accepted as the tandem index (TI). The mean age was 61.4 ± 17 years; the mean duration of tremor was 6.7 ± 4 years; and there were 36 men and 54 women. There was no significant difference for age or sex between patients and controls. Head (24.6%), jaw (5.5%), voice (11%), and tongue tremors (1.5%) were identified in ET patients. Rest (2.5%), postural (95%), and kinetic tremors (54%) were detected in the upper extremities. Postural tremor was found in the lower extremities of 5%. The mean TI was 8.3 ± 4 (median, 8) in ET patients, and 10.6 ± 3.9 (median, 10) in controls (p=0.04). Correlation analysis of TI and FTMTRS scores showed tandem gait was significantly correlated with age, total tremor score, postural and kinetic extremity tremor, writing, drawing, pouring, feeding, and working scores. Linear regression showed a significant effect of age and FTMTRS score on TI. The decrease in balance control is apparent with advancing age. Balance disorders were more pronounced in ET patients. Although first mis-step in tandem gait is not as detailed as dynamic balance tests, it can be a simple method for detecting balance disorders. Copyright © 2013 Elsevier Ltd. All rights reserved.

  2. Structure of a Longitudinal Actin Dimer Assembled by Tandem W Domains: Implications for Actin Filament Nucleation

    Energy Technology Data Exchange (ETDEWEB)

    Rebowski, Grzegorz; Namgoong, Suk; Boczkowska, Malgorzata; Leavis, Paul C.; Navaza, Jorge; Dominguez, Roberto (IBS); (BBRI); (UPENN-MED)

    2013-11-20

    Actin filament nucleators initiate polymerization in cells in a regulated manner. A common architecture among these molecules consists of tandem WASP homology 2 domains (W domains) that recruit three to four actin subunits to form a polymerization nucleus. We describe a low-resolution crystal structure of an actin dimer assembled by tandem W domains, where the first W domain is cross-linked to Cys374 of the actin subunit bound to it, whereas the last W domain is followed by the C-terminal pointed end-capping helix of thymosin {beta}4. While the arrangement of actin subunits in the dimer resembles that of a long-pitch helix of the actin filament, important differences are observed. These differences result from steric hindrance of the W domain with intersubunit contacts in the actin filament. We also determined the structure of the first W domain of Vibrio parahaemolyticus VopL cross-linked to actin Cys374 and show it to be nearly identical with non-cross-linked W-Actin structures. This result validates the use of cross-linking as a tool for the study of actin nucleation complexes, whose natural tendency to polymerize interferes with most structural methods. Combined with a biochemical analysis of nucleation, the structures may explain why nucleators based on tandem W domains with short inter-W linkers have relatively weak activity, cannot stay bound to filaments after nucleation, and are unlikely to influence filament elongation. The findings may also explain why nucleation-promoting factors of the Arp2/3 complex, which are related to tandem-W-domain nucleators, are ejected from branch junctions after nucleation. We finally show that the simple addition of the C-terminal pointed end-capping helix of thymosin {beta}4 to tandem W domains can change their activity from actin filament nucleation to monomer sequestration.

  3. Structure of a longitudinal actin dimer assembled by tandem w domains: implications for actin filament nucleation.

    Science.gov (United States)

    Rebowski, Grzegorz; Namgoong, Suk; Boczkowska, Malgorzata; Leavis, Paul C; Navaza, Jorge; Dominguez, Roberto

    2010-10-15

    Actin filament nucleators initiate polymerization in cells in a regulated manner. A common architecture among these molecules consists of tandem WASP homology 2 domains (W domains) that recruit three to four actin subunits to form a polymerization nucleus. We describe a low-resolution crystal structure of an actin dimer assembled by tandem W domains, where the first W domain is cross-linked to Cys374 of the actin subunit bound to it, whereas the last W domain is followed by the C-terminal pointed end-capping helix of thymosin β4. While the arrangement of actin subunits in the dimer resembles that of a long-pitch helix of the actin filament, important differences are observed. These differences result from steric hindrance of the W domain with intersubunit contacts in the actin filament. We also determined the structure of the first W domain of Vibrio parahaemolyticus VopL cross-linked to actin Cys374 and show it to be nearly identical with non-cross-linked W-Actin structures. This result validates the use of cross-linking as a tool for the study of actin nucleation complexes, whose natural tendency to polymerize interferes with most structural methods. Combined with a biochemical analysis of nucleation, the structures may explain why nucleators based on tandem W domains with short inter-W linkers have relatively weak activity, cannot stay bound to filaments after nucleation, and are unlikely to influence filament elongation. The findings may also explain why nucleation-promoting factors of the Arp2/3 complex, which are related to tandem-W-domain nucleators, are ejected from branch junctions after nucleation. We finally show that the simple addition of the C-terminal pointed end-capping helix of thymosin β4 to tandem W domains can change their activity from actin filament nucleation to monomer sequestration.

  4. Factors Affecting the Spatial Distribution of Oviposition Sites for Tandem Black Saddlebags Dragonflies (Odonata: Libellulidae)

    Science.gov (United States)

    Thornton, Jessica L.; Switzer, Paul V.

    2015-01-01

    Oviposition site location may be affected by (1) factors influencing the costs and benefits to the offspring (e.g., resource availability, competition, predation risk) and (2) factors influencing the costs and benefits to the female (e.g., predation risk or mate harassment). In cases in which both the male and female are involved in locating a site, costs and benefits may differ for each parent and the resulting oviposition site location may represent the outcome of selection pressures on one or both of them. We studied oviposition behavior in the black saddlebags dragonfly (Tramea lacerata Hagen), a species in which the male and female typically remain together (i.e., in tandem) while traveling among potential oviposition locations. Oviposition sites tended to be away from pond shoreline at the outer edge of the vegetation on the water’s surface. We found that tandems distributed their oviposition locations widely around the pond, and interactions with other dragonflies (typically other T. lacerata, either territorial males or tandems) led to a larger distance between consecutive oviposition locations. Interestingly, for 10% of the tandems, the female became separated from the male and oviposited solitarily multiple times. These solitary females spent significantly less time and traveled significantly smaller distances between successive oviposition sites than when in tandem. Our results indicate that while some aspects of oviposition behavior and site selection may be consistent between the male and female (e.g., the characteristics that make a site suitable), other aspects, such as the distribution of sites, may be a result of a differing benefits and costs for the two sexes, perhaps as a consequence of potential sperm competition.

  5. Tandem repeat regions within the Burkholderia pseudomallei genome and their application for high resolution genotyping

    Directory of Open Access Journals (Sweden)

    Harvey Steven P

    2007-03-01

    Full Text Available Abstract Background The facultative, intracellular bacterium Burkholderia pseudomallei is the causative agent of melioidosis, a serious infectious disease of humans and animals. We identified and categorized tandem repeat arrays and their distribution throughout the genome of B. pseudomallei strain K96243 in order to develop a genetic typing method for B. pseudomallei. We then screened 104 of the potentially polymorphic loci across a diverse panel of 31 isolates including B. pseudomallei, B. mallei and B. thailandensis in order to identify loci with varying degrees of polymorphism. A subset of these tandem repeat arrays were subsequently developed into a multiple-locus VNTR analysis to examine 66 B. pseudomallei and 21 B. mallei isolates from around the world, as well as 95 lineages from a serial transfer experiment encompassing ~18,000 generations. Results B. pseudomallei contains a preponderance of tandem repeat loci throughout its genome, many of which are duplicated elsewhere in the genome. The majority of these loci are composed of repeat motif lengths of 6 to 9 bp with 4 to 10 repeat units and are predominately located in intergenic regions of the genome. Across geographically diverse B. pseudomallei and B.mallei isolates, the 32 VNTR loci displayed between 7 and 28 alleles, with Nei's diversity values ranging from 0.47 and 0.94. Mutation rates for these loci are comparable (>10-5 per locus per generation to that of the most diverse tandemly repeated regions found in other less diverse bacteria. Conclusion The frequency, location and duplicate nature of tandemly repeated regions within the B. pseudomallei genome indicate that these tandem repeat regions may play a role in generating and maintaining adaptive genomic variation. Multiple-locus VNTR analysis revealed extensive diversity within the global isolate set containing B. pseudomallei and B. mallei, and it detected genotypic differences within clonal lineages of both species that were

  6. Aprendendo línguas estrangeiras in-tandem: histórias de identidades

    Directory of Open Access Journals (Sweden)

    Maria Luisa Vassallo

    2008-01-01

    Full Text Available A Pesquisa Narrativa de Clandinin & Connelly (2000 compreende a experiência humana como histórias vividas e contadas. Nesta abordagem qualitativa de pesquisa, os participantes contam histórias e os pesquisadores as recontam e as reconstroem por meio de narrativas acerca das experiências. Tendo este arcabouço metodológico como orientador de nossos procedimentos de pesquisa, neste artigo investigamos nossa experiência compartilhada de aprendizagem in-tandem do português e do italiano - no caso, uma experiência de oito meses por meio de um tandem face-a-face. Neste período, vivenciamos e coletamos dados acerca de nosso processo de aprender a língua um do outro: anotações de campo, mensagens reflexivas de e-mail trocadas durante o período e o conteúdo anotado durante as aulas. Ao reviver nossas histórias vividas durante aquele período, por meio da narrativa aqui apresentada, ressaltamos os elementos de identidade no nosso tandem que acreditamos estarem relacionados à aprendizagem. Também individuamos os elementos desencadeadores de identidade específicos deste contexto de aprendizagem.Narrative Inquiry (Clandinin & Connelly, 2000 understands human experience as lived and told stories. Within this qualitative mode of research, participants tell stories and researchers retell and reconstruct them through narratives about the experiences. By having this methodological framework as the backbone of our research, we have conducted a narrative inquiry into our shared experience of in-tandem learning of Portuguese and Italian - an eight month experience of a face-to-face tandem. Within this period we experienced and collected data about our learning processes of learning each other's languages: field notes, reflexive e-mail messages exchanged during that period and our notes during our lessons. As we relive our stories of that period by means of the narrative we present here, we want to highlight the identity elements in our tandem that

  7. Revascularization of tandem occlusions in acute ischemic stroke: review of the literature and illustrative case.

    Science.gov (United States)

    Mbabuike, Nnenna; Gassie, Kelly; Brown, Benjamin; Miller, David A; Tawk, Rabih G

    2017-04-01

    OBJECTIVE Tandem occlusions continue to represent a major challenge in patients with acute ischemic stroke (AIS). The anterograde approach with proximal to distal revascularization as well as the retrograde approach with distal to proximal revascularization have been reported without clear consensus or standard guidelines. METHODS The authors performed a comprehensive search of the PubMed database for studies including patients with carotid occlusions and tandem distal occlusions treated with endovascular therapy. They reviewed the type of approach employed for endovascular intervention and clinical outcomes reported with emphasis on the revascularization technique. They also present an illustrative case of AIS and concurrent proximal cervical carotid occlusion and distal middle cerebral artery occlusion from their own experience in order to outline the management dilemma for similar cases. RESULTS A total of 22 studies were identified, with a total of 790 patients with tandem occlusions in AIS. Eleven studies used the anterograde approach, 3 studies used the retrograde approach, 4 studies used both, and in 4 studies the approach was not specified. In the studies that reported Thrombolysis in Cerebral Infarction (TICI) grades, an average of 79% of patients with tandem occlusions were reported to have an outcome of TICI 2b or better. One study found good clinical outcome in 52.5% of the thrombectomy-first group versus 33.3% in the stent-first group, as measured by the modified Rankin Scale (mRS). No study evaluated the difference in time to reperfusion for the anterograde and retrograde approach and its association with clinical outcome. The patient in the illustrative case had AIS and tandem occlusion of the internal carotid and middle cerebral arteries and underwent distal revascularization using a Solitaire stent retrieval device followed by angioplasty and stent treatment of the proximal cervical carotid occlusion. The revascularization was graded as TICI 2b

  8. Aplicação do processo de enfermagem baseado na teoria de OREM: estudo de caso com uma adolescente grávida Aplicación de lo proceso de enfermería basado en la teoría de OREM: estudio de caso en una adolescente embarazada Application of the nursing process based in OREM'S theory: a case study with a pregnant adolescent

    Directory of Open Access Journals (Sweden)

    Gilson de Vasconcelos Torres

    1999-04-01

    Full Text Available Estudo do tipo descritivo com abordagem qualitativa, objetivando a aplicação do processo de enfermagem baseado na Teoria do Autocuidado de Orem, através de um estudo de caso em uma adolescente grávida, buscando identificar os diagnósticos de enfermagem na referida cliente, baseado nos diagnósticos de enfermagem da NANDA. Diante dos resultados obtidos identificou-se três diagnósticos: adaptação prejudicada, distúrbio do padrão do sono e processo familiar alterado. Destacou-se a aplicabilidade do processo de enfermagem baseado em Orem e a importância dos diagnósticos de enfermagem na prestação dos cuidados de enfermagem à cliente.Estudio de tipo descriptivo con un enfoque cualitativo, cuyo objetivo fue aplicar el proceso de enfermería utilizando la Teoría del Autocuidado de OREM, a través de un estudio de caso en una adolescente embarazada, buscando identificar los diagnósticos de la cliente, en base a los diagnósticos de la NANDA. De acuerdo con los resultados encontrados, se identificaron tres diagnósticos: adaptación perjudicada, disturbio del sueño y alteración del proceso familiar, fue relevante la aplicación del proceso de enfermería de Orem y la importancia de los diagnósticos de enfermería para dar los cuidados de enfermería a la cliente.This is a descriptive study with a qualitative approach that aimed at applying the nursing process based in Orem Self-Care Theory, through a case study with a pregnant adolescent in order to identify the nursing diagnosis in the above mentioned clients, based on NANDA'S nursing diagnoses. Results obtained identified three nursing diagnoses: prejudiced adaptation, sleep disturb and familiar change process. The application of the nursing process based in Orem and the importance of the diagnosis identified for clients nursing care were evidenced.

  9. Padronização do teste ELISA baseado em antígeno capsular purificado dos sorotipos 3, 5 e 7 de Actinobacillus pleuropneumoniae Standarization of ELISA test based on purified capsular antigen from serotypes 3, 5 and 7 of Actinobacillus pleuropneumoniae

    Directory of Open Access Journals (Sweden)

    Valéria Dutra

    2000-04-01

    Full Text Available Foram padronizados testes de ELISA (Enzyme-linked immunosorbent assay baseados em antígeno capsular purificado de Actinobacillus pleuropneumoniae sorotipos 3, 5 e 7, prevalentes no Brasil. Para a padronização foram utilizadas amostras de soro provenientes de leitões inoculados com os três sorotipos do agente em estudo, dos quais se colheram amostras de sangue semanais, durante 15 semanas para estudo da dinâmica da síntese de anticorpos. O controle negativo dos testes constituiu-se de um mistura de 130 soros de animais livres de Actinobacillus pleuropneumoniae (App. Os antígenos também foram testados com amostras de soro de animais infectados com outros agentes causadores de doenças respiratórias e vacinados contra rinite atrófica. Os antígenos produzidos foram eficientes na detecção de animais infectados com App, permitindo determinar densidades óticas superiores à média dos soros controles negativos acrescida de quatro desvios-padrões. Os testes de ELISA para os sorotipos 3, 5 e 7 apresentaram especificidade de 100% e sensibilidade de 92, 88 e 90%, respectivamente. Não ocorreram reações cruzadas com outros sorotipos, assim como com soros de animais inoculados com outros agentes causadores de problemas respiratórios. Os resultados foram analisados através da análise discriminante de ANDERSON (1958, utilizando-se o programa Statistical Analysis System. Concluiu-se que os antígenos testados são adequados para sorotipar animais que tenham sido submetidos ao screening através de um teste de ELISA polivalente baseado em LPS-LC.Three ELISA (Enzime-linked immunosorbent assay tests based on purified capsular antigen from serotypes 3, 5 and 7 of Actinobacillus pleuropneumoniae, prevalent in Brazil, were standardized. Serum samples, collected from piglets inoculated with these three serotypes, were used to standardize the test. In order to study the dynamic of antibody synthesis, weekly blood samples were collected from these

  10. Verificação e calibração do modelo de simulação do desempenho reprodutivo de vacas de corte baseado no escore de condição corporal avaliação interna Verification and calibration of a simulation model for reproductive performance of beef cows based on body condition score internal evaluation

    Directory of Open Access Journals (Sweden)

    José Acélio Silveira da Fontoura Júnior

    2010-12-01

    Full Text Available O trabalho foi desenvolvido com os objetivos de demonstrar e fazer a avaliação interna do modelo matemático desenvolvido para descrever o processo reprodutivo em sistemas de produção e simular o desempenho reprodutivo de vacas de corte a partir do escore de condição corporal ao parto (ECCPAR. O modelo é baseado na relação entre o ECCPAR e o intervalo parto-concepção (IPC para vacas com cria ao pé; para novilhas e vacas vazias à concepção, foi baseado na probabilidade de ocorrência. Para a avaliação interna do modelo, foi utilizada a metodologia de verificação e calibração. O uso da técnica de variação dos dados de entrada foi feito por meio da construção de cenários, variando ECCPAR, data de início da estação reprodutiva (IER, data média do parto (DPAR e ganho médio diário do nascimento ao desmame (GMDND. Esses cenários serviram também para demonstração do modelo. Por meio da calibração, foram escolhidos novos desvios-padrão para as variáveis: período de gestação, GMDND e data média do parto (DPAR. Os testes de degenerescência e independência de sementes geradoras de números aleatórios, após a calibração, comprovaram coerência do modelo na geração de aleatoriedade para as variáveis de interesse. A variação nos dados de entrada indicou eficácia do modelo para simular a dinâmica do processo reprodutivo, no entanto ajustes na taxa de concepção de primíparas são necessários para que o modelo simule valores compatíveis com a realidade.This work was carried out with the goal of demonstrating and performing internal evaluation of the mathematical model developed to describe the reproductive performance in production systems and to simulate reproductive performance of beef cows from the body condition score at calving (BCSAC. This model is based on the relationship between BCSAC and the interval between calving and conception (ICC for lactating cows; for heifers and empty cows at

  11. Correction: Synergism between genome sequencing, tandem mass spectrometry and bio-inspired synthesis reveals insights into nocardioazine B biogenesis.

    Science.gov (United States)

    Alqahtani, Norah; Porwal, Suheel K; James, Elle D; Bis, Dana M; Karty, Jonathan A; Lane, Amy L; Viswanathan, Rajesh

    2015-09-21

    Correction for 'Synergism between genome sequencing, tandem mass spectrometry and bio-inspired synthesis reveals insights into nocardioazine B biogenesis' by Norah Alqahtani et al., Org. Biomol. Chem., 2015, 13, 7177-7192.

  12. Discrimination of eight chloramphenicol isomers by liquid chromatography tandem mass spectrometry in order to investigate the natural occurence of chloramphenicol

    NARCIS (Netherlands)

    Berendsen, B.J.A.; Zuidema, T.; Jong, de J.; Stolker, A.A.M.; Nielen, M.W.F.

    2011-01-01

    This paper describes the discrimination of eight different isomers of chloramphenicol (CAP), an antibiotic banned for use in food producing animals, by reversed phase and chiral liquid chromatography in combination with tandem mass spectrometric detection. Previously, by liquid chromatography couple

  13. Environmentally Printing Efficient Organic Tandem Solar Cells with High Fill Factors: A Guideline Towards 20% Power Conversion Efficiency

    DEFF Research Database (Denmark)

    Li, Ning; Baran, Derya; Spyropoulos, George D.

    2014-01-01

    The tandem concept involves stacking two or more cells with complementary absorption spectra in series or parallel connection, harvesting photons at the highest possible potential. It is strongly suggested that the roll-to-roll production of organic solar cells will employ the tandem concept...... to enhance the power conversion efficiency (PCE). However, due to the undeveloped deposition techniques, the challenges in ink formulation as well as the lack of commercially available high performance active materials, roll-to-roll fabrication of highly efficient organic tandem solar cells currently...... presents a major challenge. The reported high PCE values from lab-scale spin-coated devices are, of course, representative, but not helpful for commercialization. Here, organic tandem solar cells with exceptionally high fill factors and PCE values of 7.66% (on glass) and 5.56% (on flexible substrate...

  14. Tandem Knoevenagel–Michael reactions in aqueous diethylamine medium: A greener and efficient approach toward bis-dimedone derivatives

    Directory of Open Access Journals (Sweden)

    Abdullah Mohammed Al-Majid

    2017-02-01

    The use of inexpensive, eco-friendly and readily available reagents, easy work-up, and high purity products makes the procedure a convenient and robust method for the synthesis of tandem Knoevenagel–Michael adducts.

  15. Synthesis of Heterocycles through a Ruthenium‐Catalyzed Tandem Ring‐Closing Metathesis/Isomerization/N‐Acyliminium Cyclization Sequence

    DEFF Research Database (Denmark)

    Ascic, Erhad; Jensen, Jakob Feldthusen; Nielsen, Thomas Eiland

    2011-01-01

    Tandem bicycle: In the title reaction double bonds created during ring-closing metathesis isomerize to generate reactive iminium intermediates that undergo intramolecular cyclization reactions with tethered heteroatom and carbon nucleophiles. In this way, a series of biologically interesting...

  16. [A comparative analysis of UMUDC-dependent induction of tandem duplications, point and insertional reversions in Salmonella].

    Science.gov (United States)

    Skavronskaia, A G; Andreeva, I V; Tiganova, I G; Rusina, O Iu; Mirskaia, E E

    1995-01-01

    Comparative analysis of UV induction of tandem chromosome (Mtc+) duplications and reversions of point mutations (base pair substitutions) and of insertion mutations (precise excision of Tn10) was carried out. Salmonella (umuST) genes deficiency preventing dose-dependent UV induction of point mutation reversion were shown to have a less pronounced effect on the induction of tandem chromosome duplications. UV induction of tandem chromosome duplications is similar to UV induction of insertion mutation reversion: dose-dependent UV induction of both occurs in umuST Salmonella strains. E. coli umuDC+ genes included in Salmonella genome appreciably enhance the UV induction of both tandem duplications and insertion mutation reversion. The presence of umuDC+ genes ensures an expressed dose-dependent UV induction of point mutation reversion.

  17. Synthesis of Heterocycles through a Ruthenium‐Catalyzed Tandem Ring‐Closing Metathesis/Isomerization/N‐Acyliminium Cyclization Sequence

    DEFF Research Database (Denmark)

    Ascic, Erhad; Jensen, Jakob Feldthusen; Nielsen, Thomas Eiland

    2011-01-01

    Erfolgreiches Tandem: In der Titelreaktion isomerisieren Doppelbindungen, die bei der Ringschlussmetathese erzeugt werden, wobei reaktive Iminiumintermediate entstehen, die in intramolekularen Cyclisierungen mit Seitenketten-Heteroatom- und -Kohlenstoffnucleophilen reagieren. So wurde eine Reihe ...

  18. Um modelo baseado em programação linear e programação de metas para análise de um sistema de produção e distribuição de suco concentrado congelado de laranja A model based on linear programming and goal programming to analyze a frozen concentrated orange juice production and distribution system

    Directory of Open Access Journals (Sweden)

    José Renato Munhoz

    2001-08-01

    Full Text Available Neste trabalho apresenta-se um modelo baseado em programação linear e programação de metas para apoiar decisões no processo de mistura e na distribuição de suco concentrado congelado de laranja. Explora-se a importância das decisões do processo de mistura para a análise da logística de distribuição do suco de laranja, além das decisões de transporte e armazenagem. O modelo utiliza conceitos conhecidos da literatura de problemas de mistura e planejamento da produção com múltiplos produtos, estágios e períodos, e foi resolvido por meio da linguagem de modelagem GAMS (General Algebraic Modeling System. Um estudo de caso foi realizado numa empresa de suco de laranja localizada no interior do estado de São Paulo, e os resultados preliminares obtidos são promissores.This work proposes a model based on linear programming and goal programming to support decisions in the blending process and distribution of frozen concentrated orange juice. This study explores the importance of blending decisions for the logistic analysis of the orange juice distribution, besides transportation and storage decisions. The model utilizes well-known concepts from the literature of blending problems and multistage, multiproduct and multiperiod production planning problems, and it was solved using the GAMS (General Algebraic Modeling System programming language. A case study was developed in an orange juice industry located in São Paulo State, and the preliminary results are promising.

  19. Modelo quantitativo para avaliação e melhoria de desempenho do processo de S&OP baseado no diagnóstico e redução de falhas A quantitative model for the assessment and performance improvement of S&OP process based on the diagnosis and reduction of failures

    Directory of Open Access Journals (Sweden)

    Fabio José Pandim

    2012-01-01

    Full Text Available O processo de Sales and Operations Planning - Planejamento de Vendas e Operações (S&OP, assim como qualquer processo de nível estratégico ou tático, necessita ter o seu desempenho monitorado para que seja possível realizar ações de melhoria nos aspectos que estejam gerando impactos negativos em seu desempenho. Os modelos para análise de desempenho encontrados na literatura não trazem meios para localizar as causas de ineficiência mais relevantes, quando da utilização de processos S&OP, bem como não fornecem uma maneira de se quantificar o desempenho do processo. Com o objetivo de contribuir com esta necessidade, o presente trabalho apresenta um modelo quantitativo para análise e melhoria de desempenho do processo de S&OP baseado no diagnóstico e na redução de suas ineficiências mais importantes.The S&OP process, like any business process of strategic or tactical level, requires having its performance measured so that, through the monitoring of these measurements, improvement actions for the factors affecting their performance can be created. The models for performance analysis in the literature failed to identify the most relevant causes of inefficiency to the process and do provide a way of measuring the process performance. Therefore, this paper presents a proposal for a quantitative model for the analysis and performance improvement of the S&OP process based on the diagnosis and reduction of its most important inefficiencies.

  20. Charge generation layers for solution processed tandem organic light emitting diodes with regular device architecture.

    Science.gov (United States)

    Höfle, Stefan; Bernhard, Christoph; Bruns, Michael; Kübel, Christian; Scherer, Torsten; Lemmer, Uli; Colsmann, Alexander

    2015-04-22

    Tandem organic light emitting diodes (OLEDs) utilizing fluorescent polymers in both sub-OLEDs and a regular device architecture were fabricated from solution, and their structure and performance characterized. The charge carrier generation layer comprised a zinc oxide layer, modified by a polyethylenimine interface dipole, for electron injection and either MoO3, WO3, or VOx for hole injection into the adjacent sub-OLEDs. ToF-SIMS investigations and STEM-EDX mapping verified the distinct functional layers throughout the layer stack. At a given device current density, the current efficiencies of both sub-OLEDs add up to a maximum of 25 cd/A, indicating a properly working tandem OLED.

  1. Efficiency of tandem solar cell systems as function of temperature and solar energy concentration ratio

    Science.gov (United States)

    Gokcen, N. A.; Loferski, J. J.

    1979-01-01

    The results of a comprehensive theoretical analysis of tandem photovoltaic solar cells as a function of temperature and solar concentration ratio are presented. The overall efficiencies of tandem cell stacks consisting of as many as 24 cells having gaps in the 0.7 to 3.6 eV range were calculated for temperatures of 200, 300, 400, and 500 K and for illumination by an AMO solar spectrum having concentration ratios of 1, 100, 500, and 1000 suns. For ideal diodes (A = B = 1), the calculations show that the optimized overall efficiency has a limiting value eta sub opt of approximately 70 percent for T = 200 K and C = 1000; for T = 300 K and C = 1000, this limiting efficiency approaches 60 percent.

  2. Searching molecular structure databases with tandem mass spectra using CSI:FingerID

    Science.gov (United States)

    Dührkop, Kai; Shen, Huibin; Meusel, Marvin; Rousu, Juho; Böcker, Sebastian

    2015-01-01

    Metabolites provide a direct functional signature of cellular state. Untargeted metabolomics experiments usually rely on tandem MS to identify the thousands of compounds in a biological sample. Today, the vast majority of metabolites remain unknown. We present a method for searching molecular structure databases using tandem MS data of small molecules. Our method computes a fragmentation tree that best explains the fragmentation spectrum of an unknown molecule. We use the fragmentation tree to predict the molecular structure fingerprint of the unknown compound using machine learning. This fingerprint is then used to search a molecular structure database such as PubChem. Our method is shown to improve on the competing methods for computational metabolite identification by a considerable margin. PMID:26392543

  3. Gas Chromatography/Atmospheric Pressure Chemical Ionization Tandem Mass Spectrometry for Fingerprinting the Macondo Oil Spill.

    Science.gov (United States)

    Lobodin, Vladislav V; Maksimova, Ekaterina V; Rodgers, Ryan P

    2016-07-05

    We report the first application of a new mass spectrometry technique (gas chromatography combined to atmospheric pressure chemical ionization tandem mass spectrometry, GC/APCI-MS/MS) for fingerprinting a crude oil and environmental samples from the largest accidental marine oil spill in history (the Macondo oil spill, the Gulf of Mexico, 2010). The fingerprinting of the oil spill is based on a trace analysis of petroleum biomarkers (steranes, diasteranes, and pentacyclic triterpanes) naturally occurring in crude oil. GC/APCI enables soft ionization of petroleum compounds that form abundant molecular ions without (or little) fragmentation. The ability to operate the instrument simultaneously in several tandem mass spectrometry (MS/MS) modes (e.g., full scan, product ion scan, reaction monitoring) significantly improves structural information content and sensitivity of analysis. For fingerprinting the oil spill, we constructed diagrams and conducted correlation studies that measure the similarity between environmental samples and enable us to differentiate the Macondo oil spill from other sources.

  4. Characterization of Tandem systems of commercial ionization chambers for radiation dosimetry (radiotherapy level)

    CERN Document Server

    Galhardo, E P

    1998-01-01

    The use of X rays for radiotherapy purposes is of great importance for Medicine, and it is necessary to control periodically the performance of the ionization chambers and the radiation beams in order to obtain the best results. The verification of the beam characteristics is made by using standard dosimetry procedures which include the determination of the half-value layers and the exposure rates or the absorbed dose rates in air. Several Tandem systems were set up and tested, using commercial ionization chambers in the energy interval from 14 up to 130 KeV at the Instrumentation Calibration Laboratory of IPEN and at other three institutions, in substitution to the routine conventional procedure of determination of half-value layers using absorbers. The obtained results show the usefulness of these Tandem system for the routine dosimetric procedures of radiotherapy X radiation beams.

  5. Non-Target Screening of Veterinary Drugs Using Tandem Mass Spectrometry on SmartMass

    Science.gov (United States)

    Xia, Bing; Liu, Xin; Gu, Yu-Cheng; Zhang, Zhao-Hui; Wang, Hai-Yan; Ding, Li-Sheng; Zhou, Yan

    2013-05-01

    Non-target screening of veterinary drugs using tandem mass spectrometric data was performed on the SmartMass platform. This newly developed software uses the characteristic fragmentation patterns (CFP) to identify chemicals, especially those containing particular substructures. A mixture of 17 sulfonamides was separated by ultra performance liquid chromatography (UPLC), and SmartMass was used to process the tandem mass spectrometry (MS/MS) data acquired on an Orbitrap mass spectrometer. The data were automatically extracted, and each sulfonamide was recognized and analyzed with a prebuilt analysis rule. By using this software, over 98 % of the false candidate structures were eliminated, and all the correct structures were found within the top 10 of the ranking lists. Furthermore, SmartMass could also be used to identify slightly modified contraband drugs and metabolites with simple prebuilt rules. [Figure not available: see fulltext.

  6. One-way sequencing of multiple amplicons from tandem repetitive mitochondrial DNA control region.

    Science.gov (United States)

    Xu, Jiawu; Fonseca, Dina M

    2011-10-01

    Repetitive DNA sequences not only exist abundantly in eukaryotic nuclear genomes, but also occur as tandem repeats in many animal mitochondrial DNA (mtDNA) control regions. Due to concerted evolution, these repetitive sequences are highly similar or even identical within a genome. When long repetitive regions are the targets of amplification for the purpose of sequencing, multiple amplicons may result if one primer has to be located inside the repeats. Here, we show that, without separating these amplicons by gel purification or cloning, directly sequencing the mitochondrial repeats with the primer outside repetitive region is feasible and efficient. We exemplify it by sequencing the mtDNA control region of the mosquito Aedes albopictus, which harbors typical large tandem DNA repeats. This one-way sequencing strategy is optimal for population surveys.

  7. First operation of ATLAS using the PII linac and a comparison to tandem injection

    Energy Technology Data Exchange (ETDEWEB)

    Pardo, R.C.; Bollinger, L.M.; Billquist, P.J.; Bogaty, J.M.; Clifft, B.E.; Markovich, P.; Munson, F.H.; Shepard, K.W.; Zinkann, G.P.

    1991-12-31

    The ATLAS Positive Ion Injector (PII) is designed to replace the tandem injector for the ATLAS heavy-ion facility. When the PII project is complete, ATLAS will be able to accelerate all ions through uranium to energies above the Coulomb barrier. PII consists of an ECR ion source on a 350 kV platform and a very low-velocity superconducting linac. The PII project is nearing completion. First beam from the complete system is expected in early 1992. Beam tests and experiments using a partially completed PII linac have demonstrated that the technical design goals are being met. The results of the early beam tests and first experiments will be discussed and compared to the performance of ATLAS with tandem injection. 10 refs., 2 figs.

  8. First operation of ATLAS using the PII linac and a comparison to tandem injection

    Energy Technology Data Exchange (ETDEWEB)

    Pardo, R.C.; Bollinger, L.M.; Billquist, P.J.; Bogaty, J.M.; Clifft, B.E.; Markovich, P.; Munson, F.H.; Shepard, K.W.; Zinkann, G.P.

    1991-01-01

    The ATLAS Positive Ion Injector (PII) is designed to replace the tandem injector for the ATLAS heavy-ion facility. When the PII project is complete, ATLAS will be able to accelerate all ions through uranium to energies above the Coulomb barrier. PII consists of an ECR ion source on a 350 kV platform and a very low-velocity superconducting linac. The PII project is nearing completion. First beam from the complete system is expected in early 1992. Beam tests and experiments using a partially completed PII linac have demonstrated that the technical design goals are being met. The results of the early beam tests and first experiments will be discussed and compared to the performance of ATLAS with tandem injection. 10 refs., 2 figs.

  9. Ion mobility tandem mass spectrometry enhances performance of bottom-up proteomics.

    Science.gov (United States)

    Helm, Dominic; Vissers, Johannes P C; Hughes, Christopher J; Hahne, Hannes; Ruprecht, Benjamin; Pachl, Fiona; Grzyb, Arkadiusz; Richardson, Keith; Wildgoose, Jason; Maier, Stefan K; Marx, Harald; Wilhelm, Mathias; Becher, Isabelle; Lemeer, Simone; Bantscheff, Marcus; Langridge, James I; Kuster, Bernhard

    2014-12-01

    One of the limiting factors in determining the sensitivity of tandem mass spectrometry using hybrid quadrupole orthogonal acceleration time-of-flight instruments is the duty cycle of the orthogonal ion injection system. As a consequence, only a fraction of the generated fragment ion beam is collected by the time-of-flight analyzer. Here we describe a method utilizing postfragmentation ion mobility spectrometry of peptide fragment ions in conjunction with mobility time synchronized orthogonal ion injection leading to a substantially improved duty cycle and a concomitant improvement in sensitivity of up to 10-fold for bottom-up proteomic experiments. This enabled the identification of 7500 human proteins within 1 day and 8600 phosphorylation sites within 5 h of LC-MS/MS time. The method also proved powerful for multiplexed quantification experiments using tandem mass tags exemplified by the chemoproteomic interaction analysis of histone deacetylases with Trichostatin A.

  10. Low Cost Amorphous Silicon Intrinsic Layer for Thin-Film Tandem Solar Cells

    Directory of Open Access Journals (Sweden)

    Ching-In Wu

    2013-01-01

    Full Text Available The authors propose a methodology to improve both the deposition rate and SiH4 consumption during the deposition of the amorphous silicon intrinsic layer of the a-Si/μc-Si tandem solar cells prepared on Gen 5 glass substrate. It was found that the most important issue is to find out the saturation point of deposition rate which guarantees saturated utilization of the sourcing gas. It was also found that amorphous silicon intrinsic layers with the same k value will result in the same degradation of the fabricated modules. Furthermore, it was found that we could significantly reduce the production cost of the a-Si/μc-Si tandem solar cells prepared on Gen 5 glass substrate by fine-tuning the process parameters.

  11. A new modified tandem appliance for management of developing Class III malocclusion

    Directory of Open Access Journals (Sweden)

    Ram Sukh

    2013-01-01

    Full Text Available Most developing Class III patients display a retruded maxilla. Early intervention in mixed dentition is associated with better patient compliance and possibly a better orthopedic response, which can produce favorable results. The aim of this article is to present the fabrication of the new modified tandem appliance and its use in management of developing Class III malocclusion. The therapeutic results of a new modified tandem appliance are presented in an 8 year-old male patient with anterior cross bite and retrognathic maxilla at the mixed dentition stage. Anterior cross bite was corrected in 3 months and the positive overjet of 4 mm after continued use of the appliance for 1 year. There was a significant improvement in profile of the patient. The use of this appliance in this type of malocclusion enabled the correction of malocclusion in a few months and encouraging favorable skeletal growth in the future.

  12. Differentiating samples and experimental protocols by direct comparison of tandem mass spectra

    DEFF Research Database (Denmark)

    van der Plas-Duivesteijn, Suzanne J.; Wulff, Tune; Klychnikov, Oleg;

    2016-01-01

    compares spectra between liquid chromatography/tandem mass spectrometry (LC/MS/MS) datasets to determine the shared spectral content, and demonstrated how this can be applied in a molecular phylogenetic study using sera from human and non-human primates. We will here explore if such a method have other...... protein digests in different types of experiments. There is no reason to assume that our instance of this method is optimal in any of these situations, as it makes limited or no use of accurate mass and chromatographic retention time. We propose that with further improvement and refinement, this type...... of analysis can be applied as a simple but informative first step in many pipelines for bottom-up tandem mass spectrometry data analysis in proteomics and other fields, comparing or analysing large numbers of samples or datasets....

  13. Flexible organic tandem solar modules: a story of up-scaling

    Science.gov (United States)

    Spyropoulos, George D.; Kubis, Peter; Li, Ning; Lucera, Luca; Salvador, Michael; Baran, Derya; Machui, Florian; Ameri, Tayebeh; Voigt, Monika M.; Brabec, Christoph J.

    2014-10-01

    The competition in the field of solar energy between Organic Photovoltaics (OPVs) and several Inorganic Photovoltaic technologies is continuously increasing to reach the ultimate purpose of energy supply from inexpensive and easily manufactured solar cell units. Solution-processed printing techniques on flexible substrates attach a tremendous opportunity to the OPVs for the accomplishment of low-cost and large area applications. Furthermore, tandem architectures came to boost up even more OPVs by increasing the photon-harvesting properties of the device. In this work, we demonstrate the road of realizing flexible organic tandem solar modules constructed by a fully roll-to-roll compatible processing. The modules exhibit an efficiency of 5.4% with geometrical fill factors beyond 80% and minimized interconnection-resistance losses. The processing involves low temperature (coating methods compatible with slot die coating and high speed and precision laser patterning.

  14. Focusing of tandem bistatic SAR data using the chirp-scaling algorithm

    Science.gov (United States)

    Chen, Shichao; Xing, Mengdao; Zhou, Song; Zhang, Lei; Bao, Zheng

    2013-12-01

    Based on an exact analytical bistatic point target spectrum, an efficient chirp-scaling algorithm is proposed to correct the range cell migration of different range gates to the one of the reference range for tandem bistatic synthetic aperture radar data processing. The length of the baseline (baseline to range ratio) does not give a direct influence to the proposed algorithm, which can be applied to the processing of tandem bistatic data with a large baseline even when the baseline is equal to the range. No interpolation is needed during the entire processing, only fast Fourier transforms and phase multiplications are needed, which result in efficiency. The validity of the proposed algorithm has been verified by simulated experiments.

  15. Modeling of the electrical carrier transport in III-V on silicon tandem solar cell structures

    Science.gov (United States)

    Maiti, T. K.; Cheong, Dan; Yang, Jingfeng; Kleiman, R. N.

    2011-08-01

    The electrical carrier transport of a tandem cell structure was evaluated by investigating the band alignment of and carrier transport through a tunnel junction. The modeling structure of a tandem cell consists of a III-V (or II-VI) top cell layer, a Si bottom cell layer and tunnel junction layers in-between which connect the top and the bottom cells. The values of energy bandgap and electron affinity of each layer were varied to investigate their effect on the energy barrier height at the interface between Si and compound semiconductors of interest. The contour plots of barrier heights for majority and minority carriers at the hetero-interface are used as a starting point to define the successful regions for electrical carrier transport through the tunnel junctions.

  16. Effective optical path length for tandem diffuse cubic cavities as gas absorption cell

    Science.gov (United States)

    Yu, J.; Gao, Q.; Zhang, Y. G.; Zhang, Z. G.; Wu, S. H.

    2014-12-01

    Tandem diffuse cubic cavities designed by connecting two single diffuse cubic-shaped cavities, A and B, with an aperture (port fraction fap) in the middle of the connecting baffle was developed as a gas absorption cell. The effective optical path length (EOPL) was evaluated by comparing the oxygen absorption signal in the cavity and in air based on tunable diode laser absorption spectroscopy (TDLAS). Experimental results manifested an enhancement of EOPL for the tandem diffuse cubic cavities as the decrease of fap and can be expressed as the sum of EOPL of two single cubic cavities at fap 0.01, which indicated that back scattering light from cavity B to cavity A cannot be ignored at this condition.

  17. Fast quantitative detection of cocaine in beverages using nanoextractive electrospray ionization tandem mass spectrometry.

    Science.gov (United States)

    Hu, Bin; Peng, Xuejiao; Yang, Shuiping; Gu, Haiwei; Chen, Huanwen; Huan, Yanfu; Zhang, Tingting; Qiao, Xiaolin

    2010-02-01

    Without any sample pretreatment, effervescent beverage fluids were manually sprayed into the primary ion plume created by using a nanoelectrospray ionization source for direct ionization, and the analyte ions of interest were guided into an ion trap mass spectrometer for tandem mass analysis. Functional ingredients (e.g., vitamins, taurine, and caffeine, etc.) and spiked impurity (e.g., cocaine) in various beverages, such as Red Bull energy drink, Coco-cola, and Pepsi samples were rapidly identified within 1.5 s. The limit of detection was found to be 7-15 fg (S/N = 3) for cocaine in different samples using the characteristic fragment (m/z 150) observed in the MS(3) experiments. Typical relative standard deviation and recovery of this method were 6.9%-8.6% and 104%-108% for direct analysis of three actual samples, showing that nanoextractive electrospray ionization tandem mass spectrometry is a useful technique for fast screening cocaine presence in beverages.

  18. Efficient direct solar-to-hydrogen conversion by in situ interface transformation of a tandem structure.

    Science.gov (United States)

    May, Matthias M; Lewerenz, Hans-Joachim; Lackner, David; Dimroth, Frank; Hannappel, Thomas

    2015-09-15

    Photosynthesis is nature's route to convert intermittent solar irradiation into storable energy, while its use for an industrial energy supply is impaired by low efficiency. Artificial photosynthesis provides a promising alternative for efficient robust carbon-neutral renewable energy generation. The approach of direct hydrogen generation by photoelectrochemical water splitting utilizes customized tandem absorber structures to mimic the Z-scheme of natural photosynthesis. Here a combined chemical surface transformation of a tandem structure and catalyst deposition at ambient temperature yields photocurrents approaching the theoretical limit of the absorber and results in a solar-to-hydrogen efficiency of 14%. The potentiostatically assisted photoelectrode efficiency is 17%. Present benchmarks for integrated systems are clearly exceeded. Details of the in situ interface transformation, the electronic improvement and chemical passivation are presented. The surface functionalization procedure is widely applicable and can be precisely controlled, allowing further developments of high-efficiency robust hydrogen generators.

  19. Generalized Shape and Gauge Decoupling Load Distribution Optimization Based on IGA for Tandem Cold Mill

    Institute of Scientific and Technical Information of China (English)

    PENG Peng; YANG Quan

    2009-01-01

    Load distribution is the foundation of shape control and gauge control, in which it is necessary to take into account the shape control ability of TCM (tandem cold mill) for strip shape and gauge quality. First, the objective function of generalized shape and gauge decoupling load distribution optimization was established, which considered the rolling force characteristics of the first and last stands in TCM, the relative power, and the TCM shape control ability. Then, IGA (immune genetic algorithm) was used to accomplish this multi-objective load distribution optimization for TCM. After simulation and comparison with the practical load distribution strategy in one tandem cold mill, general-ized shape and gauge decoupling load distribution optimization on the basis of IGA approved good ability of optimizing shape control and gauge control simultaneously.

  20. Nanocomposite catalyst with palladium nanoparticles encapsulated in a polymeric acid: A model for tandem environmental catalysis

    KAUST Repository

    Isimjan, Tayirjan T.

    2013-04-01

    The synthesis and characterization of a novel hybrid nanocomposite catalyst comprised of palladium nanoparticles embedded in polystyrene sulfonic acid (PSSH) and supported on metal oxides is reported. The catalysts are intended for application in green catalysis, and they are shown to be effective in the hydrolysisreduction sequence of tandem catalytic reactions required for conversion of 2-phenyl-1,3-dioxolane to toluene or of phenol to cyclohexane. The two distinct components in the catalyst, Pd nanoparticles and acidic PSSH, are capable of catalyzing sequential reactions in one pot under mild conditions. This work has demonstrated a powerful approach toward designing highperformance, multifunctional, scalable, and environmentally friendly nanostructured tandem catalysts. © 2013 American Chemical Society.

  1. Four- and Sixfold Tandem-Domino Reactions Leading to Dimeric Tetrasubstituted Alkenes Suitable as Molecular Switches.

    Science.gov (United States)

    Tietze, Lutz F; Waldecker, Bernd; Ganapathy, Dhandapani; Eichhorst, Christoph; Lenzer, Thomas; Oum, Kawon; Reichmann, Sven O; Stalke, Dietmar

    2015-08-24

    A highly efficient palladium-catalyzed fourfold tandem-domino reaction consisting of two carbopalladation and two C-H-activation steps was developed for the synthesis of two types of tetrasubstituted alkenes 3 and 6 with intrinsic helical chirality starting from substrates 1 and 4, respectively. A sixfold tandem-domino reaction was also developed by including a Sonogashira reaction. 20 compounds with different substitution patterns were prepared with yields of up to 97 %. Structure elucidation by X-ray crystallography confirmed helical chirality of the two alkene moieties. Photophysical investigations of some of the compounds showed pronounced switching properties through light-controlled changes of their stereochemical configuration. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  2. Biological Matrix Effects in Quantitative Tandem Mass Spectrometry-Based Analytical Methods: Advancing Biomonitoring

    Science.gov (United States)

    Panuwet, Parinya; Hunter, Ronald E.; D’Souza, Priya E.; Chen, Xianyu; Radford, Samantha A.; Cohen, Jordan R.; Marder, M. Elizabeth; Kartavenka, Kostya; Ryan, P. Barry; Barr, Dana Boyd

    2015-01-01

    The ability to quantify levels of target analytes in biological samples accurately and precisely, in biomonitoring, involves the use of highly sensitive and selective instrumentation such as tandem mass spectrometers and a thorough understanding of highly variable matrix effects. Typically, matrix effects are caused by co-eluting matrix components that alter the ionization of target analytes as well as the chromatographic response of target analytes, leading to reduced or increased sensitivity of the analysis. Thus, before the desired accuracy and precision standards of laboratory data are achieved, these effects must be characterized and controlled. Here we present our review and observations of matrix effects encountered during the validation and implementation of tandem mass spectrometry-based analytical methods. We also provide systematic, comprehensive laboratory strategies needed to control challenges posed by matrix effects in order to ensure delivery of the most accurate data for biomonitoring studies assessing exposure to environmental toxicants. PMID:25562585

  3. Dimensional ranges and rolling efficiency in a tandem cold rolling mill

    Energy Technology Data Exchange (ETDEWEB)

    Larkiola, J.

    1997-12-31

    In this work, physical models and a neural network theory have been combined in order to predict the properties of a steel strip and to optimise the process parameters in cold rolling. The prediction of the deformation resistance of the material and the friction parameter is based on the physical model presented by Bland, Ford and Ellis and artificial neural network computing (ANN). The accuracy of these models has been tested and proved by using a large amount of the measured data. With the aid of these models it has been shown that (a) the small change to the relative reduction distribution can have a clear effect upon the rolling efficiency, (b) the dimensional ranges of the tandem cold roll mill can be determined and optimised and (c) the possibility to cold roll a new product of new width, strength or thickness can be determined and the parameters of the tandem cold rolling process can be optimised. (orig.) 43 refs.

  4. Silver Nanoparticle-Doped Titanium Oxide Thin Films for Intermediate Layers in Organic Tandem Solar Cell

    Directory of Open Access Journals (Sweden)

    Wanyi Nie

    2013-01-01

    Full Text Available In this work we investigate the Ag nanoparticle doping of TiOx used as an intermediate layer between subcells of a tandem organic photovoltaic. We use a model polymer cell structure of P3HT:TiOx:PEDOT:P3HT to observe charge-trapping effects as a function of nanoparticle content in the TiOx, as determined by the shape of the dark and illuminated current voltage curves of the devices. There is a direct correlation between the amount of Ag nanoparticles in the TiOx, and interfacial charge buildup, and charge trapping being completely mitigated at around 0.2% mol. This suggests that such doping schemes might provide a simple approach to the creation and use of TiOx layers for tandem cells.

  5. Structure and Notch receptor binding of the tandem WWE domain of Deltex.

    Science.gov (United States)

    Zweifel, Mark E; Leahy, Daniel J; Barrick, Doug

    2005-11-01

    Deltex is a cytosolic effector of Notch signaling thought to bind through its N-terminal domain to the Notch receptor. Here we report the structure of the Drosophila Deltex N-terminal domain, which contains two tandem WWE sequence repeats. The WWE repeats, which adopt a novel fold, are related by an approximate two-fold axis of rotation. Although the WWE repeats are structurally distinct, they interact extensively and form a deep cleft at their junction that appears well suited for ligand binding. The two repeats are thermodynamically coupled; this coupling is mediated in part by a conserved segment that is immediately C-terminal to the second WWE domain. We demonstrate that although the Deltex WWE tandem is monomeric in solution, it forms a heterodimer with the ankyrin domain of the Notch receptor. These results provide structural and functional insight into how Deltex modulates Notch signaling, and how WWE modules recognize targets for ubiquitination.

  6. VUV synchrotron radiation: a new activation technique for tandem mass spectrometry.

    Science.gov (United States)

    Milosavljević, Aleksandar R; Nicolas, Christophe; Gil, Jean-Francois; Canon, Francis; Réfrégiers, Matthieu; Nahon, Laurent; Giuliani, Alexandre

    2012-03-01

    A novel experimental technique for tandem mass spectrometry and ion spectroscopy of electrosprayed ions using vacuum-ultraviolet (VUV) synchrotron radiation is presented. Photon activation of trapped precursor ions has been performed by coupling a commercial linear quadrupole ion trap (Thermo scientific LTQ XL), equipped with the electrosprayed ions source, to the DESIRS beamline at the SOLEIL synchrotron radiation facility. The obtained results include, for the first time on biopolymers, photodetachment spectroscopy using monochromated synchrotron radiation of multi-charged anions and the single photon ionization of large charge-selected polycations. The high efficiency and signal-to-noise ratio achieved by the present set-up open up possibilities of using synchrotron light as a new controllable activation method in tandem mass spectrometry of biopolymers and VUV-photon spectroscopy of large biological ions.

  7. Application of CBZ dimer, C343 and SQ dye as photosensitizers for pn-tandem DSCs

    Science.gov (United States)

    Lee, Yong Hyi; Park, Ji Young; Thogiti, Suresh; Cheruku, Rajesh; Kim, Jae Hong

    2016-07-01

    A pn-tandem dye-sensitized solar cell ( pn-DSC) was prepared with three different sensitized dyes CBZ Dimer (CBZD), C343, and SQ in two different compartments of the n-type or p-type cells. The constructed tandem solar cell was exhibited considerable improvement in experimental pn-DSCs parameters, open-circuit voltage, short-circuit current, fill factor, etc. These results were achieved under air mass 1.5 illumination with three different sensitized dyes in the upper and lower compartment of the pn-DSCs. These results demonstrate a complementary absorption among the two photoelectrodes in the pn-DSCs is a good approach to the efficient and low cost pn-DSCs. [Figure not available: see fulltext.

  8. Numerical Simulation of Luminescent Downshifting in Top Cell of Monolithic Tandem Solar Cells

    Directory of Open Access Journals (Sweden)

    Mahfoud Abderrezek

    2013-01-01

    Full Text Available The increase in the conversion efficiency of monolithic tandem solar cells is limited by the short-circuit current density matching between the top and the bottom cells. Generally, the top cell presents the lowest current in the two subcells. In this paper, in order to increase the short-circuit current density in the top cell, we present a theoretical survey of the luminescence downshifting (LDS approach for the design of monolithic tandem solar cells. The photovoltaic (PV glass encapsulation material is replaced with a polymer material of polymethyl methacrylate (PMMA type which is doped with diverse kinds of organic dyes. The performance of the n-p-p+ GaInP structure has been simulated as a function of the organic dyes. Gains achieved for the short-circuit current density and conversion efficiency are, respectively, 13.13% and 13.38%, under AM1.5G illumination spectra.

  9. A new modified tandem appliance for management of developing Class III malocclusion.

    Science.gov (United States)

    Sukh, Ram; Singh, Gyan P; Tandon, Pradeep

    2013-10-01

    Most developing Class III patients display a retruded maxilla. Early intervention in mixed dentition is associated with better patient compliance and possibly a better orthopedic response, which can produce favorable results. The aim of this article is to present the fabrication of the new modified tandem appliance and its use in management of developing Class III malocclusion. The therapeutic results of a new modified tandem appliance are presented in an 8 year-old male patient with anterior cross bite and retrognathic maxilla at the mixed dentition stage. Anterior cross bite was corrected in 3 months and the positive overjet of 4 mm after continued use of the appliance for 1 year. There was a significant improvement in profile of the patient. The use of this appliance in this type of malocclusion enabled the correction of malocclusion in a few months and encouraging favorable skeletal growth in the future.

  10. Genome-wide analysis of tandem repeats in Tribolium castaneum genome reveals abundant and highly dynamic tandem repeat families with satellite DNA features in euchromatic chromosomal arms.

    Science.gov (United States)

    Pavlek, Martina; Gelfand, Yevgeniy; Plohl, Miroslav; Meštrović, Nevenka

    2015-12-01

    Although satellite DNAs are well-explored components of heterochromatin and centromeres, little is known about emergence, dispersal and possible impact of comparably structured tandem repeats (TRs) on the genome-wide scale. Our bioinformatics analysis of assembled Tribolium castaneum genome disclosed significant contribution of TRs in euchromatic chromosomal arms and clear predominance of satellite DNA-typical 170 bp monomers in arrays of ≥5 repeats. By applying different experimental approaches, we revealed that the nine most prominent TR families Cast1-Cast9 extracted from the assembly comprise ∼4.3% of the entire genome and reside almost exclusively in euchromatic regions. Among them, seven families that build ∼3.9% of the genome are based on ∼170 and ∼340 bp long monomers. Results of phylogenetic analyses of 2500 monomers originating from these families show high-sequence dynamics, evident by extensive exchanges between arrays on non-homologous chromosomes. In addition, our analysis shows that concerted evolution acts more efficiently on longer than on shorter arrays. Efficient genome-wide distribution of nine TR families implies the role of transposition only in expansion of the most dispersed family, and involvement of other mechanisms is anticipated. Despite similarities in sequence features, FISH experiments indicate high-level compartmentalization of centromeric and euchromatic tandem repeats.

  11. Where Will Russia's Domestic and Foreign Policies Go under the "Medvedev-Putin Tandem"?(detailed abstracts)

    Institute of Scientific and Technical Information of China (English)

    Wang Lijiu

    2008-01-01

    @@ Ⅰ. The Medvedev-Putin Tandem Is Necessary for Russia's Rejuvenation Why is it called the"Medvedev-Putin Tandem"?Russia's constitution stipulates that president is the head of state who shall be responsible for defining and supervising the implementation of the political,economic,diplomatic,and security guidelines and policies,while prime minister is the head of government who shall be responsible for working out and carrying out these guidelines and policies in detail.

  12. SU-E-T-661: Quantitative MRI Assessment of a Novel Direction-Modulated Brachytherapy Tandem Applicator for Cervical Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Soliman, A; Elzibak, A; Fatemi, A; Safigholi, H; Leung, E; Ravi, A; Song, W [Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Ontario (Canada); Han, D [Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Ontario (Canada); University of California, San Diego, La Jolla, CA (United States)

    2015-06-15

    Purpose: To quantitatively evaluate the MR image quality of a novel direction modulated brachytherapy (DMBT) tandem applicator for cervical cancer, using the clinical MRI scanning protocol for image guided brachytherapy. Methods: The tungsten alloy-based applicator was placed in a water phantom and clinical imaging protocol was performed. Axial images were acquired using 2D turbo-spin echo (TSE) T2-weighted sequence on a 1.5T GE 450w MR scanner and an 8-channel body coil. As multi-channel receiver coil was used, inhomogeneities in the B1 receive field must be considered before performing the quantification process. Therefore the applicator was removed from the phantom and the whole imaging session was performed again for the water phantom with the same parameters. Images from the two scans were then subtracted, resulting in a difference image that only shows the applicator with its surrounding magnetic susceptibility dipole artifact. Line profiles were drawn and plotted on the difference image at various angles and locations along the tandem. Full width at half maximum (FWHM) was measured at all the line profiles to quantify the extent of the artifact. Additionally, the extent of the artifact along the diameter of the tandem was measured at various angles and locations. Results: After removing the background inhomogeneities of the receiver coil, FWHM of the tandem measured 5.75 ± 0.35 mm (the physical tandem diameter is 5.4 mm). The average extent of the artifacts along the diameter of the tandem measured is 2.14 ± 0.56 mm. In contrast to CT imaging of the same applicator (not shown here), the tandem can be easily identified without additional correction algorithms. Conclusion: This work demonstrated that the novel DMBT tandem applicator has minimal susceptibility artifact in T2-weighted images employed in clinical practice for MRI-guided brachytherapy of cervical cancer.

  13. SU-C-16A-07: Sculpting Isodose Lines: Design of An Internally Shielded Tandem for Cervical Cancer Brachytherapy

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, M; Yue, N; Zou, J [Rutgers University, New Brunswick, NJ (United States); Mo, X [21st Century Oncology, Madison, WI (United States)

    2014-06-15

    Purpose: With the prescription method moving from point A to 3D volume based in cervical cancer HDR brachytherapy, the traditional pear-shaped isodose lines are desired to be sculptured to conform to the irregular shaped target. The standard single channel tandem cannot generate asymmetric isodose lines. Most of the directionally shielded sources proposed in literature are challenging to manufacture and operate. In this study, we proposed a novel internally shielded tandem applicator design which gave users more freedom to manipulate isodose lines while planning. Methods: The proposed tandem design has one centrally located lead cylindrical rod of 8 mm in diameter serving as the internal shield. Multiple source channels with the diameter of 2 mm are evenly spaced and engraved on the central cylindrical rod. The overall diameter of the tandem with polymer encapsulation was kept to be 10 mm. Various number of channels and engraving depths have been tested in the design process. Geant4 Monte Carlo toolkit was used for dose calculation assuming a Varian VS2000 source was placed inside the applicator. A Monte Carlo based planning system has been developed in-house to generate brachytherapy plans. Test plans by using this internally shielded tandem were generated for 3 clinical cases. Results: Water phantom results shown the dose distribution from a VS2000 source in the tandem was strongly distorted towards one direction due to the presence of shielding material. Conformal plans with asymmetric isodose distributions around the tandem can be generated by optimizing dwell times in different channels. Conclusion: An effective and easy-to-use internally shielded tandem was developed. It gave user the freedom to sculpt isodose lines to generate conformal plans for cervical cancer brachytherapy.

  14. Homo-Tandem Polymer Solar Cells withVOC>1.8 V for Efficient PV-Driven Water Splitting

    KAUST Repository

    Gao, Yangqin

    2016-03-06

    Efficient homo-tandem and triple-junction polymer solar cells are constructed by stacking identical subcells composed of the wide-bandgap polymer PBDTTPD, achieving power conversion efficiencies >8% paralleled by open-circuit voltages >1.8 V. The high-voltage homo-tandem is used to demonstrate PV-driven electrochemical water splitting with an estimated solar-to-hydrogen conversion efficiency of ≈6%. © 2016 WILEY-VCH Verlag GmbH & Co.

  15. Half-life of Si-32 from tandem-accelerator mass spectrometry

    Science.gov (United States)

    Elmore, D.; Anantaraman, N.; Fulbright, H. W.; Gove, H. E.; Nishiizumi, K.; Murrell, M. T.; Honda, M.; Hans, H. S.

    1980-01-01

    A newly developed mass-spectrometry technique employing a tandem Van de Graaff accelerator together with a special beam-transport system and heavy-ion detector has been used to determine the half-life of Si-32. The result obtained, 108 plus or minus 18 yr, disagrees with the accepted value of 330 plus or minus 40 yr. The implications of the new half-life of Si-32, which is used for dating studies, are discussed.

  16. lobSTR: A short tandem repeat profiler for personal genomes

    OpenAIRE

    Gymrek, Melissa; Golan, David; Rosset, Saharon; Erlich, Yaniv

    2012-01-01

    Short tandem repeats (STRs) have a wide range of applications, including medical genetics, forensics, and genetic genealogy. High-throughput sequencing (HTS) has the potential to profile hundreds of thousands of STR loci. However, mainstream bioinformatics pipelines are inadequate for the task. These pipelines treat STR mapping as gapped alignment, which results in cumbersome processing times and a biased sampling of STR alleles. Here, we present lobSTR, a novel method for profiling STRs in p...

  17. One-pot tandem Barbier-Prins synthesis of tetrahydropyrans in aqueous media

    Institute of Scientific and Technical Information of China (English)

    WEN Meijiao; TANG Long; CHANG Weixing; LI Jing

    2005-01-01

    By investigating the effect of the amount of water, the ratio of aldehyde and allylbromide, and the reaction temperature on the transformation, 2,4,6-trisubstituted tetrahydropyrans are synthesized by a novel tandem Barbier-Prins-cyclization reaction in the presence of micro-amount of water under mild conditions. The experiment is easy to perform without the need to exclude moisture or air. The reaction is atomic economical and environmentally benign.

  18. Real-time PCR and PCR-tandem Mass Spectrometry for Biodetection

    Science.gov (United States)

    2005-10-01

    Real - time PCR and PCR- tandem mass spectrometry for biodetection Alvin Fox, University of South Carolina, School of Medicine Report Documentation...TYPE N/A 3. DATES COVERED - 4. TITLE AND SUBTITLE Real - time PCR and PCRtandem mass spectrometry for biodetection 5a. CONTRACT NUMBER 5b...interspace region Bacillus subtilis W23 standard Blank Barn dust House dust Cycle Real - time PCR (16s rRNA) - environmental samples Real - time

  19. Synfuels from fusion: using the tandem mirror reactor and a thermochemical cycle to produce hydrogen

    Energy Technology Data Exchange (ETDEWEB)

    Werner, R.W. (ed.)

    1982-11-01

    This study is concerned with the following area: (1) the tandem mirror reactor and its physics; (2) energy balance; (3) the lithium oxide canister blanket system; (4) high-temperature blanket; (5) energy transport system-reactor to process; (6) thermochemical hydrogen processes; (7) interfacing the GA cycle; (8) matching power and temperature demands; (9) preliminary cost estimates; (10) synfuels beyond hydrogen; and (11) thermodynamics of the H/sub 2/SO/sub 4/-H/sub 2/O system. (MOW)

  20. Finalize field testing of cold climate heat pump (CCHP) based on tandem vapor injection compressors

    Energy Technology Data Exchange (ETDEWEB)

    Shen, Bo [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Baxter, Van D. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Abdelaziz, Omar [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Rice, C. Keith [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2017-03-01

    This report describes the system diagram and control algorithm of a prototype air-source cold climate heat pump (CCHP) using tandem vapor injection (VI) compressors. The prototype was installed in Fairbanks, Alaska and underwent field testing starting in 09/2016. The field testing results of the past six months, including compressor run time fractions, measured COPs and heating capacities, etc., are presented as a function of the ambient temperature. Two lessons learned are also reported.