WorldWideScience

Sample records for kv network development

  1. French 400 kV network

    Energy Technology Data Exchange (ETDEWEB)

    Pelissier, R

    1965-11-01

    A 400 kV transmission network has been constructed to carry hydroelectric power from the Alps and the Massif Central to Paris at peak hours and to carry power in the reverse direction in off-peak hours. A double circuit-ring at 400 kV encircling the Paris region is also nearing completion. Measures have to be taken to counter the very high short-circuit currents in such a network. A 730 kV network will eventually become necessary. The consequent multiplicity of transmission voltages will give rise to further problems. Collaboration with neighboring countries is envisaged. The problems of stability and synchronization posed by the new system are described and solutions suggested. The new circuit-breaking requirements are discussed, and details of tower design for 400 kV and 730 kV are given.

  2. Protection system for 11kV network using arc noise

    International Nuclear Information System (INIS)

    Burdi, M.K.; Memon, A.S.; Shaikh, S.A.

    2000-01-01

    Extensive research work is being done on protecting devices for 11KV network using arc noise and fault noise frequencies in relay to operate a circuit breaker; The relay works on the principle of detecting fault and extracting voltage signal output from the noise frequencies across filter. The voltage development without amplification, is enough to operate the circuit breaker. Sensitivity of the circuit breaker. In this paper design, operation and application of the relay are described. (author)

  3. Development of 66 kV/6.9 kV 2 MV A prototype HTS power transformer

    International Nuclear Information System (INIS)

    Bohno, T.; Tomioka, A.; Imaizumi, M.; Sanuki, Y.; Yamamoto, T.; Yasukawa, Y.; Ono, H.; Yagi, Y.; Iwadate, K.

    2005-01-01

    We have developed the technology of the producing a HTS magnet for the power transformer. Three subjects have been mainly studied, high voltage technologies, large current and low AC loss technologies and sub-cooling system technologies to establish the technology of 66 kV/6.9 kV 10 MV A class HTS power transformer. In order to verify the validity of elemental technologies, such as high voltage technologies, large current and low AC loss technologies and sub-cooling system technologies, single-phase 2 MV A class 66 kV/6.9 kV prototype HTS transformer was manufactured and tested. In the load loss (AC loss) measurement, it was obtained that the measured value of 633 W was almost corresponding to the calculated value of 576 W at the rated operation of 2 MV A. Moreover, the breakdown was not found all voltage withstand test. These test results indicate that elemental technologies were established for the development of 66 kV/6.9 kV 10 MV A class HTS power transformer

  4. Systems for protection and automation of distribution electric networks 22 kv

    International Nuclear Information System (INIS)

    Horak, M.

    2012-01-01

    This article deals with the new concept of fault location in overhead and cable 22 kV distribution systems, which are operated by ZSE Distribucia, a.s.. In the past the localisation of faults was a demanding and lengthy procedure, because the electric protection indicated only the affected output feeder. The exact fault point was then localised by manipulation in the field and by test switching in the power line where the fault took place. The current development of electric facilities and sharp fall in prices give use the possibility to broadly apply the simple digital metering devices equipped with the electric protection function. Once these devices are positioned densely along the individual power lines of the network, it is possible to localise the failure position quite exactly and electricity supply can be quickly restored. (Authors)

  5. A neutral grounding metallic resistor failure in a 35 kV network

    Directory of Open Access Journals (Sweden)

    Simić Ninoslav

    2011-01-01

    Full Text Available This paper presents the results of observations and measurements of the impedance of the metal resistor for grounding neutral of the 35 kV network, before and after damaging event. The proposed measures are to be taken in order to eliminate a failure in this particular case, as well as the prevention of similar events.

  6. Measurements of Voltage Harmonics in 400 kV Transmission Network

    Directory of Open Access Journals (Sweden)

    Ryszard Pawełek

    2014-06-01

    Full Text Available The paper deals with the analysis of voltage harmonics measurements performed in the 400 kV transmission network. The voltage was measured by means of three transducers: resistive voltage divider, inductive measuring transformer and capacitive voltage measuring transformer. Instrument errors were estimated for measuring transformers with reference to the harmonic values obtained from the voltage divider.

  7. Improving the Transmission System Reliability for the 154kV Radial Network Operation

    Energy Technology Data Exchange (ETDEWEB)

    Choo, Jin Boo; Yoo, Myeong Ho; Yoon, Young Beum; Kim, Tae Won [Korea Electric Power Research Institute, Taejon (Korea, Republic of); Lee, Gi Won; Chung, Beom Jin; Jung, Jung Won; Park, Kyu Hyun; Lee, Myung Hee; Kim, Hyun Jong; Kim, Chae Hee [KEYIN CO., (Korea, Republic of)

    1996-12-31

    Analyzing that 154kV radial network current ed operated, we developed Automatic Power Reconfiguration System(APRS) which restore blackout area. It consists of special data acquisition system(DAU) and central monitoring system for reason of protecting currently operating power system. In addition, it communicates using optical communication network for high speed data transmission and accuracy. An Accuracy of operation and stability of the developed system is tested using Real Time Digital Simulator in 3-bus equivalent model system. In An Outage case, our developed system can restore a blackout area in three second. An ability of the restoration of a blackout was verified by simulations. For the field test, the developed system was set up at SINCHON S/S, SESOMUN S/S, SINDANG S/S and MAJANG S/S governed by Seoul Power Transmission Center. If the system reliability is proved for a one year test in real power system, application of the system will be extended to the other substations.

  8. Future 400 kV Algerian network and radio electric disturbances in dry weather and under rain

    Directory of Open Access Journals (Sweden)

    Brahami M.

    2007-01-01

    Full Text Available The development of the electrical power networks to very high voltage (V.H.V reveals problems involved in the high electric fields; it is essential to consider it in the design of installations in order to avoid or to mitigate some problematic or dangerous effects. Among the most important harmful effects, we can note the "radio interference disturbances". The principal aim of this paper is the use of a simulation programme using an analytical method based on the theory of propagation modes, made by one of the authors, for determination and calculation of the exact profile of disturbance field of actual high voltage lines (220 kV and in project (400 kV in dry weather and under rain. Specific software called "effect corona" was developed for this purpose.

  9. Development of 600 kV triple resonance pulse transformer.

    Science.gov (United States)

    Li, Mingjia; Zhang, Faqiang; Liang, Chuan; Xu, Zhou

    2015-06-01

    In this paper, a triple-resonance pulse transformer based on an air-core transformer is introduced. The voltage across the high-voltage winding of the air-core transformer is significantly less than the output voltage; instead, the full output voltage appears across the tuning inductor. The maximum ratio of peak load voltage to peak transformer voltage is 2.77 in theory. By analyzing pulse transformer's lossless circuit, the analytical expression for the output voltage and the characteristic equation of the triple-resonance circuit are presented. Design method for the triple-resonance pulse transformer (iterated simulation method) is presented, and a triple-resonance pulse transformer is developed based on the existing air-core transformer. The experimental results indicate that the maximum ratio of peak voltage across the load to peak voltage across the high-voltage winding of the air-core transformer is approximately 2.0 and the peak output voltage of the triple-resonance pulse transformer is approximately 600 kV.

  10. On low-resistance neutral earthing mode in 20 kV overhead and cable networks

    Directory of Open Access Journals (Sweden)

    Mayorov Andrey

    2017-01-01

    Full Text Available The problems of justification and selection of the required single-phase short-circuit current values in cable and overhead networks of 20 kV with low-resistance neutral earthing are considered. It is shown that the desired values of the short-circuit current can be determined on the basis of harmonization of conflicting influencing factors: reliability of the relay protection and automation devices and required resistances of the earthing devices of electrical installations, including personnel safety. In this case, the main influencing factor is the electrical network structure and parameters

  11. Back-to-Back Energization of a 60kV Cable Network - Inrush Currents Phenomenon

    DEFF Research Database (Denmark)

    Faria da Silva, Filipe; Bak, Claus Leth; Hansen, M. Lind

    2010-01-01

    On November 2008 the Danish government decided that all Danish transmission lines with a rated voltage equal to and below 150kV must be put underground, in order to reduce the visual pollution caused by Overhead Lines. This decision will lead to a massive use of underground cables in the Danish...... Network, and force a change in the approach used until now when planning, analyzing and operating electrical power systems. One problem that might arise is the energization of cables in parallel, as this operation may originate high inrush currents, which represent a risk to the circuit breakers connected...

  12. Overvoltages transferred from a network of 220 kV to 15.65 kV level of the step-up transformer in HPP 'Bajina Bašta'

    Directory of Open Access Journals (Sweden)

    Vukelja Petar

    2011-01-01

    Full Text Available The paper presents the results of research in lightning surge waves and switching overvoltages transferred from a network of 220 kV to the 15.65 kV level of the step-up transformer in HPP 'Bajina Bašta'. Analysis of survey results lead to conclusion that transferred overvoltages can endanger 15.65 kV transformer windings and stator winding insulation. It was therefore suggested for the protection of the 15.65 kV isolation to install metal oxide surge arresters at a suitable place between the power generator bus bars and earthing.

  13. The development of a 200 kV monochromated field emission electron source

    Energy Technology Data Exchange (ETDEWEB)

    Mukai, Masaki, E-mail: mmukai@jeol.co.jp [JEOL Ltd., 3-1-2 Musashino, Akishima, Tokyo 196-8558 (Japan); Kim, Judy S. [University of Oxford, Department of Materials, Parks Road, Oxford, OX1 3PH (United Kingdom); Omoto, Kazuya; Sawada, Hidetaka; Kimura, Atsushi; Ikeda, Akihiro; Zhou, Jun; Kaneyama, Toshikatsu [JEOL Ltd., 3-1-2 Musashino, Akishima, Tokyo 196-8558 (Japan); Young, Neil P.; Warner, Jamie H.; Nellist, Peter D.; Kirkland, Angus I. [University of Oxford, Department of Materials, Parks Road, Oxford, OX1 3PH (United Kingdom)

    2014-05-01

    We report the development of a monochromator for an intermediate-voltage aberration-corrected electron microscope suitable for operation in both STEM and TEM imaging modes. The monochromator consists of two Wien filters with a variable energy selecting slit located between them and is located prior to the accelerator. The second filter cancels the energy dispersion produced by the first filter and after energy selection forms a round monochromated, achromatic probe at the specimen plane. The ultimate achievable energy resolution has been measured as 36 meV at 200 kV and 26 meV at 80 kV. High-resolution Annular Dark Field STEM images recorded using a monochromated probe resolve Si–Si spacings of 135.8 pm using energy spreads of 218 meV at 200 kV and 217 meV at 80 kV respectively. In TEM mode an improvement in non-linear spatial resolution to 64 pm due to the reduction in the effects of partial temporal coherence has been demonstrated using broad beam illumination with an energy spread of 134 meV at 200 kV. - Highlights: • Monochromator for 200 kV aberration corrected TEM and STEM was developed. • Monochromator produces monochromated and achromatic probe at specimen plane. • Ultimate energy resolution was measured to be 36 meV at 200 kV and 26 meV at 80 kV. • Atomic resolution STEM images were recorded using monochromated electron probe. • Improvements of TEM resolution were confirmed using monochromated illumination.

  14. The development of a 200 kV monochromated field emission electron source

    International Nuclear Information System (INIS)

    Mukai, Masaki; Kim, Judy S.; Omoto, Kazuya; Sawada, Hidetaka; Kimura, Atsushi; Ikeda, Akihiro; Zhou, Jun; Kaneyama, Toshikatsu; Young, Neil P.; Warner, Jamie H.; Nellist, Peter D.; Kirkland, Angus I.

    2014-01-01

    We report the development of a monochromator for an intermediate-voltage aberration-corrected electron microscope suitable for operation in both STEM and TEM imaging modes. The monochromator consists of two Wien filters with a variable energy selecting slit located between them and is located prior to the accelerator. The second filter cancels the energy dispersion produced by the first filter and after energy selection forms a round monochromated, achromatic probe at the specimen plane. The ultimate achievable energy resolution has been measured as 36 meV at 200 kV and 26 meV at 80 kV. High-resolution Annular Dark Field STEM images recorded using a monochromated probe resolve Si–Si spacings of 135.8 pm using energy spreads of 218 meV at 200 kV and 217 meV at 80 kV respectively. In TEM mode an improvement in non-linear spatial resolution to 64 pm due to the reduction in the effects of partial temporal coherence has been demonstrated using broad beam illumination with an energy spread of 134 meV at 200 kV. - Highlights: • Monochromator for 200 kV aberration corrected TEM and STEM was developed. • Monochromator produces monochromated and achromatic probe at specimen plane. • Ultimate energy resolution was measured to be 36 meV at 200 kV and 26 meV at 80 kV. • Atomic resolution STEM images were recorded using monochromated electron probe. • Improvements of TEM resolution were confirmed using monochromated illumination

  15. The Reviewing of Distributed Power Sources Impact on Fallout’s Localization in 22 kV Network

    Directory of Open Access Journals (Sweden)

    Peter Bracinik

    2008-01-01

    Full Text Available The aim of this paper is to point out some facts that will occur by fault localization in 22 kV networks after the implementation of distributed power sources, especially wind power plants. This paper describes possible connection of these sources into power system in regard to their rated output. It also presents short theoretical background for short circuit calculation in 22 kV network. Then several examples explaining how the point of wind power plant connection can influence network’s operation during short-circuits and consequential fault’s localization are described in the second part of this paper

  16. Development and use of 60 kV, and 150 kV floating deck modulators for high voltage protection of multi-megawatt ion beam accelerators

    International Nuclear Information System (INIS)

    Barber, G.C.; Ponte, N.S.; Schilling, G.

    1977-01-01

    Extraction currents of 60 A at 40 kV have been produced by utilizing a 60 kV floating deck modulator interfaced to a high voltage power supply. The modulator is operated in a series mode to repetitively pulse power to the ion beam accelerator. Current monitoring and other protective circuits provide interrupt commands to the series switch tube when faults occur. The constant current characteristics of the water cooled tetrode and the rapid response of the protective circuits effectively limit the fault energy to the ion source. Three of the 60 kV decks have been modified and stacked in a series configuration to supply 150 kV, 50 A pulses. This system supplies power for development of higher-energy multi-grid sources. In this system attention has been focused on forced voltage sharing of the three decks and on protective circuits for fault conditions. All control signal processing and conditioning is performed at ground level. Fiber optic links are used to interface with the high potential associated with the floating decks. A shunt modulator incorporated with this system provides regulation of the voltage to the ion source gradient grid. Future modulator development includes a system to deliver 100 A at 80 kV

  17. The 12th 735-kV transmission line project: Hydro-Quebec network

    International Nuclear Information System (INIS)

    1992-01-01

    Hydro-Quebec is proposing to construct a 735-kV transmission line from the Chissibi station near the LG3 hydroelectric power plant to the Jacques-Cartier station near Quebec City. The width of the right-of-way will generally be 90 m and it is intended to install the line in two stages. The Chissibi-Chibougamau section should enter service in 1993 and the Chibougamau-Cartier section in 1994. The cost of the line is estimated at $1.21 billion, of which $900 million is for line construction and $310 million for station equipment. Prospective corridors for the line route have been selected, portions of which enable twinning with Hydro-Quebec's existing 9th 735-kV line. A series of hearings on the environmental and other impacts of the power line project was held by the Bureau d'audiences publiques sur l'environnement and results are summarized along with the views of the Bureau. The summary describes the justification for the project, the choice of the transmission line route, the evaluation of the impacts of the project on the natural and human environments, health effects due to magnetic fields, and effects on the economic development of northern Quebec. Recommendations are given for mitigating the impacts of the project. 13 refs., 8 figs., 2 tabs

  18. Development of Highly Selective Kv1.3-Blocking Peptides Based on the Sea Anemone Peptide ShK

    Directory of Open Access Journals (Sweden)

    Michael W. Pennington

    2015-01-01

    Full Text Available ShK, from the sea anemone Stichodactyla helianthus, is a 35-residue disulfide-rich peptide that blocks the voltage-gated potassium channel Kv1.3 at ca. 10 pM and the related channel Kv1.1 at ca. 16 pM. We developed an analog of this peptide, ShK-186, which is currently in Phase 1b-2a clinical trials for the treatment of autoimmune diseases such as multiple sclerosis and rheumatoid arthritis. While ShK-186 displays a >100-fold improvement in selectivity for Kv1.3 over Kv1.1 compared with ShK, there is considerable interest in developing peptides with an even greater selectivity ratio. In this report, we describe several variants of ShK that incorporate p-phophono-phenylalanine at the N-terminus coupled with internal substitutions at Gln16 and Met21. In addition, we also explored the combinatorial effects of these internal substitutions with an alanine extension at the C-terminus. Their selectivity was determined by patch-clamp electrophysiology on Kv1.3 and Kv1.1 channels stably expressed in mouse fibroblasts. The peptides with an alanine extension blocked Kv1.3 at low pM concentrations and exhibited up to 2250-fold selectivity for Kv1.3 over Kv1.1. Analogs that incorporates p-phosphono-phenylalanine at the N-terminus blocked Kv1.3 with IC50s in the low pM range and did not affect Kv1.1 at concentrations up to 100 nM, displaying a selectivity enhancement of >10,000-fold for Kv1.3 over Kv1.1. Other potentially important Kv channels such as Kv1.4 and Kv1.6 were only partially blocked at 100 nM concentrations of each of the ShK analogs.

  19. Full Scale Earth Fault Experiments on 10 kV laboratory network with comparative Measurements on Conventional CT's and VT's

    DEFF Research Database (Denmark)

    Sørensen, Stefan; Nielsen, Hans Ove; Bak-Jensen, Birgitte

    2002-01-01

    In this paper we present a result of a full scale earth fault carried out on the 10 kV research/laboratory distribution network at Kyndbyvaerket Denmark in May 2001. The network is compensated through a Petersen-Coil and current and voltage measurements were measured on conventional current....... The necessity of high bandwidth measurement equipment for earth fault measurements on compensated distribution networks can be undermined, since it will be shown that the transient signal transfer through conventional CT?s and VT?s for further signal analysis is sufficient. Caused the inadequacy three phase...

  20. Evaluation of cooperation WPP and PV connected through the shared transformer to the network 22kV

    Directory of Open Access Journals (Sweden)

    Tomas Sumbera

    2012-01-01

    Full Text Available The article deals with evaluation the cooperation possibility of wind and solar power plants connected through the common transformator to the 22kV network. Cooperation evaluation is, based on measured data, for wind power plant about installed capacity 2MW and for solar power plant about installed capacity 1,1MWp. In the next part of this article there is the analysis of suitable localities for construction of „hybrid system (WPP+PV“ in the Czech Republic. The last part of the article deals with analysis of active power fluctuation of individuals electric sources compared with system WPP+PV and with evaluation the effects after system connection WPP+PV to the 22kV network.

  1. EFFECTS OF STEEL PLANTS WITH THREE-PHASE INDUCTION FURNACES ON POWER DISTRIBUTION QUALITY OF THE EXISTING 33 kV NETWORK IN NIGERIA

    Directory of Open Access Journals (Sweden)

    Saheed Lekan Gbadamosi

    2015-08-01

    Full Text Available This study aimed at evaluating and analyzing the voltage and current distortions on the introduction of a steel production plant in a typical 33 kV distribution system in Nigeria, with a view to assisting decisions made in the present system operation and planning effective service delivery in terms of quality. A three phase induction furnace was developed using MatLab Simulink software and the effects of steel plant loads on the quality of electric power system supply to electricity users on the same distribution network was analyzed in terms of total harmonic distortions of voltage and current. In order to evaluate voltage magnitude profile on the network, load flow computation and analyses were carried out on the 33 kV distribution network before and after the introduction of steel plant loads, using Successive Approximation Method. The results showed critical voltage magnitude profile below -5% of nominal voltage at the receiving end nodes. With the aid of the Matlab Simulink model, inadmissible voltage and current distortions of 15.47% and 10.35% were measured. Passive filter was proposed, designed and simulated, in order to mitigate these distortions caused by the steel production plant loads. By simulation, the installation of the designed passive filter gave a reduction of the distortions to permissible values. Further, for every 1 MW load increment when the steel plant is connected, network losses increased by 94%; however, for every of Mvar of filter capacity, loss reduction in the network is 5.1 MW.

  2. Undelivered electricity as an indicator of the effects of automation in the 10 kV network PD ED Belgrade

    Directory of Open Access Journals (Sweden)

    Vrcelj Nada

    2013-01-01

    Full Text Available The paper discusses the effects of automation in the 10 kV PD ED Belgrade valorized through undelivered electricity. In the paper it was observed the parts of the network for which it was possible to reconstruct the events of the past. Calculations undelivered electricity were carried out for the period prior to the implementation of recloser in remote control system and during the period of probation system. A significant reduction in the duration of the fault, and thus undelivered electricity in automated network, indicates an increase in the reliability level after the implementation in the system SCADA SN.

  3. ON THE NEED TO INCREASE THE RELIABILITY OF LINEAR INSULATORS FOR DISTRIBUTION NETWORKS 10-20 KV

    Directory of Open Access Journals (Sweden)

    Yu. N. Shumilov

    2018-02-01

    Full Text Available Introduction. In Ukraine high voltage overhead distribution lines (OL of class 6 and 10 kV are the most extended. Their total length exceeds 280,000 km. More than 95% of the lines are made on line supports from reinforced concrete racks. On all poles of the overhead line, pin insulators are installed. According to the data of operation experience, up to 60-70% of single-phase earth (SPE faults due to «insulation» occurs on VL supports due to damage to line pin insulators, mainly during the thunderstorm period. Problem. Insufficient reliability of pin insulators leads to interruptions in power supply, accidents on the line, accidents in the area of reinforced concrete poles, where in the case of insulator damages, a long process of SPE occurs. Goal. The purpose of the work is to select the design and develop requirements for new linear insulators of 10-20 kV overhead lines that provide high resistance to lightning overvoltages with direct and inductive effects of lightning. Methodology. The research methodology consists in analyzing operational experience, calculating insulator parameters and laboratory tests. Results. Using statistical data on lightning parameters and data on mechanical loads on insulators, the main dimensions of line post insulators have been determined that will ensure their reliable operation under conditions of intense thunderstorm activity and extreme ice and wind loads. Conclusions. The main technical requirements for line post insulators for 10-20 kV distribution lines were formulated. On the 10 kV OL located in areas with increased thunderstorm activity it is recommended to use line post insulators instead of pin-type ones. On the OL-20 kV it is recommended to use only line post insulators. The use of high-lightning-resistant line post insulators on OL-10-20 kV will significantly increase the electrical safety and reliability of power supply to consumers. Increased by 2-3 times the cost of line post insulators in

  4. Development of a high current 250 kV photocathode dc gun

    International Nuclear Information System (INIS)

    Nishimori, Nobuyuki; Nagai, Ryoji; Sawamura, Masaru; Hajima, Ryoichi

    2016-01-01

    We have developed a high current photocathode dc gun at JAEA for the next generation light sources such as an energy recovery linac and high-repetition rate X-ray free electron laser. The gun is equipped with a multialkali photocathode preparation system. Quantum efficiency of 0.37% at 532 nm was obtained for a Cs_3Sb photocathode. The gun was high voltage conditioned up to 230 kV with a cathode electrode. Beam generation test from the multialkali photocathode will be performed by the end of FY2015. (author)

  5. California-Oregon 500-kV transmission line development of design criteria

    International Nuclear Information System (INIS)

    Simpson, K.D.

    1990-01-01

    The California-Oregon Transmission Project (COTP) encompassed the design and construction of a third 500-kV ac intertie between California and the Pacific Northwest Transmission system. Sargent ampersand Lundy's (S ampersand L) scope of work in the COTP includes the design of approximately 150 miles of new single-circuit, 500-kV transmission line from southern Oregon to the vicinity of Redding, California. This paper presents the development of the design criteria for this segment of the project, which crosses diverse topographic and climatic regions. This project is an example of the increasing utilization of computers in transmission line engineering. Almost all aspects of design involved the use of the computer. Also, the development of the design criteria for this project coincided with an early release of the TLWorkstation software package by EPRI. TLWorkstation is an engineering workstation containing a family of programs for various aspects of transmission line design. This engineering software allows for increasing refinement in the design and economic optimization of transmission lines and is becoming an important design tool for transmission engineers

  6. Increase in the number of distributed power generation installations in electricity distribution grids - Simulation in a 16 kV medium-voltage network; Zunahme der dezentralen Energieerzeugungsanlagen in elektrischen Verteilnetzen: Simulationen im 16 kV Mittelspannungsnetz des AEW

    Energy Technology Data Exchange (ETDEWEB)

    Hoeckel, M.; Luechinger, P.

    2003-07-01

    This is the seventh part of a ten-part final report for the Swiss Federal Office of Energy (SFOE) on a project that looked into potential problems relating to the Swiss electricity distribution grid with respect to the increasing number of distributed power generation facilities being put into service. The identification of special conditions for the grid's operation and future development that take increasing decentralised power production into account are discussed. The results of the project activities encompass the analysis and evaluation of various problem areas associated with planning and management of the grid during normal operation and periods of malfunction, as well as required modifications to safety systems and grid configurations. This sixth appendix to the main report presents and discusses the results of simulations made on the basis of the real-life 16 kV medium-voltage distribution network operated by the Aargovian electricity utility AEW. This appendix describes the simulation methods used and the basic characteristics of medium-voltage networks and distributed generation facilities. Different types of load profiles, including domestic and industrial loads, are discussed. The results of the simulations are presented in graphical form and provide profiles of voltage and current, active and reactive power and further mains characteristics for varying load conditions. Also, daily profiles for situations with and without distributed generation are presented and short-circuit simulations and grid dynamics are discussed.

  7. Experimental investigations of overvoltages in 6kV station service cable networks of thermal power plants

    Energy Technology Data Exchange (ETDEWEB)

    Vukelja, P.I.; Naumov, R.M.; Drobnjak, G.V.; Mrvic, J.D. [Nikola Tesla Inst., Belgrade (Yugoslavia)

    1996-12-31

    The paper presents the results of experimental investigations of overvoltages on 6kV isolated neutral station service cable networks of thermal power plants. The overvoltages were recorded with capacitive voltage measurement systems made at the Nikola Tesla Institute. Wideband capacitive voltage measurement systems recorded a flat response from below power frequencies to 10MHz. Investigations of overvoltages were performed for appearance and interruption of metal earth faults, intermittent earth faults, switching operation of HV motors switchgear, switching operation of transformers switchgear, and transfer of the network supply from one transformer to another. On the basis of these investigations, certain measures are proposed for limiting overvoltages and for the reliability of station service of thermal power plants.

  8. Development of a 300-kV Marx generator and its application to drive ...

    Indian Academy of Sciences (India)

    Accelerator and Pulse Power Division, Bhabha Atomic Research Centre, ... anode gap of 7·5 mm, an REB having beam voltage 160 kV and duration 150 ns ... lowest stage has a triggered SG which is closed by a 6 kV pulse obtained with the ...

  9. Improvements in the computation of balances and localization of commercial losses of electric energy in 0.38-kV networks

    International Nuclear Information System (INIS)

    Vorotnitskii, V. Z.; Zaslonov, S. V.; Lysyuk, S. S.

    2006-01-01

    An example of four 0.38-kV overhead distribution lines fed from a 10/0.4-kV transformer substation of the Grodno Electrical Networks (Belarus') and supplying electricity to a cottage area is used for analyzing energy balances and commercial losses in the networks. It is shown that the reliability of such analysis can be ensured by the use of modern software and electronic energy meters recording a retrospective of half-hourly intervals of active and reactive electric energy

  10. Risk assessment of 170 kV GIS connected to combined cable/OHL network

    DEFF Research Database (Denmark)

    Bak, Claus Leth; Kessel, Jakob; Atlason, Vidir

    2009-01-01

    performance, compared to a system consisting solely of AIS connected through overhead lines. The main purpose is to investigate whether overvoltage protection is necessary at the GIS busbar. The analysis is conducted by implementing a simulation model in PSCAD/EMTDC. Simulations are conducted for both SF......This paper concerns different investigations of lightning simulation of a combined 170 kV overhead line/cable connected GIS. This is interesting due to the increasing amount of underground cables and GIS in the Danish transmission system. This creates a different system with respect to lightning...... and BFO. Overvoltages are evaluated for varying front times of the lightning surge, different soil resistivities at the surge arrester grounding in the overhead line/cable transition point and a varying length of the connection cable between the transformer and the GIS busbar with a SA implemented...

  11. High power thyristors with 5 kV blocking voltage. Volume 1: Development of high-voltage-thyristors (4.5 kV) with good dynamic properties

    Science.gov (United States)

    Lock, K.; Patalong, H.; Platzoeder, K.

    1979-01-01

    Using neutron irradiated silicon with considerably lower spread in resistivity as compared to conventionally doped silicon it was possible to produce power thyristors with breakdown voltages between 3.5 kV and 5.5 kV. The thyristor pellets have a diameter of 50 mm. Maximum average on-state currents of 600 to 800 A can be reached with these elements. The dynamic properties of the thryistors could be improved to allow standard applications up to maximum repetitive voltages of 4.5 kV.

  12. The Development of Computer-Aided Design for Electrical Equipment Selection and Arrangement of 10 Kv Switchgear

    Directory of Open Access Journals (Sweden)

    Chernaya Anastassiya

    2015-01-01

    Full Text Available The paper intends to give an overview of a computer-aided design program application. The research includes two main parts: the development of a computer-aided design for an appropriate switchgear selection and its arrangement in an indoor switchgear layout. Matlab program was used to develop a computer-aided design system. The use of this program considerably simplifies the selection and arrangement of 10 kV switchgear.

  13. 110 kV NETWORK TECHNICAL LOSSES ASSESSMENT. REAL DISTRIBUTION SYSTEM CASE STUDY

    Directory of Open Access Journals (Sweden)

    BARBULESCU C.

    2015-06-01

    Full Text Available The paper is focusing on evaluating the technical losses within a real distribution network. The study was conducted for a distribution system operator within the Romanian Power System. The analysed area is represented by a real part of the Romanian Power System. It is modelled in a computer aided power system analysis tool. Several power system operating conditions are analysed. Power system optimization measures are provided having as a goal to reduce the technical losses' value. Values obtained based on the field measurement are compared to the ones provided by computer simulations. These conclusions are very useful for the distribution network operator.

  14. Automatización de la red de 34,5kV en la provincia de Villa Clara; Automation of 34,5 kV network in the province of Villa Clara

    Directory of Open Access Journals (Sweden)

    Obedi Álvarez Díaz

    2012-11-01

    Full Text Available En la actualidad la operación de la redes de 34.5kV de la provincia de Villa Clara se hace muy complejo debido a que los desconectivos existentes son operados manualmente por el personal y los tiempos de operación son extensos. El objetivo de la implementación de la automatización de las redes de 34.5kV en Villa Clara es operar dicha red de la forma más eficiente posible, donde se le suministre la energía eléctrica a los clientes con mínimos costos de operación, alto nivel de confiabilidad, disminución de la frecuencia de interrupciones y también de los tiempos. Se seleccionaron los lazos más importantes de la provincia, los cuales incluyen generación distribuida, realizándoles corridas de flujo de carga usando el software PowerSystem Explorer (PSX, obteniendo los lugares donde se deben colocar los recerradores. Estos se comunicarán entre sí, pudiendo ser configurables para distintas condiciones, además de poder operarlos a distancia.  At present the operation of the 34.5kV network of the province of Villa Clara is very complex because the existing disconnected are operated by staff and operating times are long. The objective of the implementation of the automation 34.5 kV networks in Villa Clara is operate as efficiently way as possible, where you supply the electricity to customers with minimal operating costs, high reliability, reduced the frequency of interruptions and the times. There have been selected the most important loops in the province, which include distributed generation, performing load flow runs using the Power System Explorer software(PSX, obtaining the locations should be placed reclosing. They shall communicate with each otherand can be configured for different conditions, in addition to being to operate them at a distance.

  15. submitter Development of a 100 kW, 12.5 kV, 22 kHz and 30 kV insulated medium frequency transformer for compact and reliable medium voltage power conversion

    CERN Document Server

    Isler, Stephane; Aguglia, Davide; Bonnin, Xavier Abel

    2017-01-01

    This paper presents the critical design aspects addressed during the development of a 100 kW, 12.5 kV, 22 kHz, and 30 kV insulated medium frequency transformer used in a power converter. The transformers are used in a resonant multilevel converter topology producing HV DC voltage from a three phase 400 V AC industrial grid. The power converter is used to supply radio frequency systems in particle accelerators. Considerations about material selection, dielectric, magnetic and thermal design are discussed and experimental results on the full scale transformer and power converter are presented.

  16. Voltage and reactive power in the 380/220 kV power network of the new German Laender - state and prospects. Spannung und Blindleistung im 380/220-kV-Verbundnetz der neuen Bundeslaender - Stand und Ausblick

    Energy Technology Data Exchange (ETDEWEB)

    Behnke, M; Luettig, K; Radtke, H [Verbundnetz Elektroenergie AG, Berlin (Germany)

    1991-01-01

    With the preparation for restoring a German power network after nearly 40 years of separate development of the EES of the former DDR, the voltage/reactive power regulation must be examined and evaluated in the conditions of: - parting the connections to the present VES partners Poland and Czechoslovakia with the option of rectification - taking up parallel operation with the adjacent network undertakings of the old West German Laender (Preussen Elektra AG and Bayernwerke AG), ie: combined operation with DVG (superregional network of old West German Laender) and UCPTE (European electrical energy union). The aim is to configure this in the 380/220 kV network of the new German Laender, so that with a regionally compensated reactive power system, the voltage can be kept steady much better at times of heavy and light load, and the network losses can be reduced. (orig./GL).

  17. harmonic load modeling: a case study of 33 kv abuja steel mill feeder

    African Journals Online (AJOL)

    HOD

    techniques are adopted. This paper studied the harmonic orders of the 33 kV Abuja Steel Feeder modeled as a ... (ETAP) software package was deployed to perform Discrete Fast Transform (DFT) while the input ... and documented in research and development articles ... network with 33kV Abuja Steel feeder as case study.

  18. Development of 6.6 kV/600 A superconducting fault current limiter using coated conductors

    Energy Technology Data Exchange (ETDEWEB)

    Yazawa, T., E-mail: takashi.yazawa@toshiba.co.j [Toshiba Corporation, Power Systems Company (Japan); Koyanagi, K.; Takahashi, M.; Toba, K.; Takigami, H.; Urata, M. [Toshiba Corporation, Power Systems Company (Japan); Iijima, Y.; Saitoh, T. [Fujikura Ltd. (Japan); Amemiya, N. [Superconductivity Research Laboratory, ISTEC (Japan); Shiohara, Y. [Department of Electrical Engineering, Kyoto University (Japan); Ito, T. [Tokyo Gas Co., Ltd. (Japan)

    2009-10-15

    As one of the programs in the Ministry of Economy, Trade and Industry (METI) project regarding R and D on superconducting coated conductor, three-phase superconducting fault current limiter (SFCL) for 6.6 kV application was developed and successfully tested. The developed SFCL was mainly comprised three-phase set of current limiting coils installed in a sub-cooled nitrogen cryostat with a GM cryocooler, circuit breakers and a sequence circuit. The whole system was installed in a cubicle. Two tapes of coated conductor were wound in parallel in each coil to obtain the rated current of 72 A rms. After developing the whole SFCL system, short circuit experiments were implemented with a short circuit generator. In a three-line ground fault test, the SFCL successfully restricted the prospected short circuit current over 1.6 kA to about 800 A by the applied voltage of 6.6 kV. The SFCL was installed in a user field and connected with a gas engine generator, followed by a consecutive operation. In this program, 600 A class FCL coil, with which four coated conductor tapes were wound, was also developed. The coil showed sufficiently low AC loss at the rated current. With these results, the program attained the planned target of the fundamentals for the 6.6 kV/600 A SFCL.

  19. Design and development of a high-power, 500 kV pulsed line

    International Nuclear Information System (INIS)

    Nicolas, A.

    A study was made of very high voltage (500 kV) pulse production for 50 ns at half height. A coaxial line was coupled to a Marx generator for obtaining the pulses on an impedance-adapted electron diode. The maximum power obtained was 6.4 x 10 10 W with a current front in the diode of about 30 ns (80 ns pulse length at half height)

  20. Research on data integration of Anshan 10 kV power distribution network system

    Energy Technology Data Exchange (ETDEWEB)

    Jiang, T.; Dang, N.; Liu, Y. [North China Electric Power Univ., Beijing (China); Wang, Z. [Anshan Electric Co. Ltd., Anshan City (China)

    2009-03-11

    Variations in data formats among electric power supervisory control systems are preventing the development of an integrated power distribution database. The use of standard XML protocols make web-based services platform and language independent, as they are based on open standards that allow software to communicate in a standardizing XML messaging system. This article discussed the use of web-based services as a safe interface for accessing distribution system databases. Web services technology was used to pass through the firewall of individual data servers while avoiding direct contact with the actual database and ensuring the security of the data server. A virtual machine technology was then applied in a testing environment to demonstrate the method. The test results confirmed that the method can be used to integrate data from various power systems. 8 refs., 5 figs.

  1. Development of 10 kV 4H-SiC JBS diode with FGR termination

    International Nuclear Information System (INIS)

    Huang Runhua; Tao Yonghong; Cao Pengfei; Wang Ling; Li Rui; Chen Gang; Bai Song; Li Yun; Zhao Zhifei

    2014-01-01

    The design, fabrication, and electrical characteristics of the 4H-SiC JBS diode with a breakdown voltage higher than 10 kV are presented. 60 floating guard rings have been used in the fabrication. Numerical simulations have been performed to select the doping level and thickness of the drift layer and the effectiveness of the edge termination technique. The n-type epilayer is 100 μm in thickness with a doping of 6 × 10 14 cm −3 . The on-state voltage was 2.7 V at J F = 13 A/cm 2 . (semiconductor devices)

  2. Preliminary study on development of 300 Kv compact focused gaseous ion beam system

    Energy Technology Data Exchange (ETDEWEB)

    Ohkubo, T.; Ishii, Y.; Kamiya, T. [Takasaki Advanced Radiation Research Institute, Japan Atomic Energy Agency (JAEA) 1233 Watanuki-machi, Takasaki, Gunma, 370-1292 (Japan); Miyake, Y. [Beam Seiko Instruments Inc., 2-10-1 Kamata, Ohta-ku, Tokyo, 144-0052 (Japan)

    2013-04-19

    A new 300 kV compact focused gaseous ion beam (gas-FIB) system with three-stage acceleration lens was constructed at JAEA. The preliminary experiments of formation of the focused gaseous ion beams were carried out to show the availability of the gas-FIB system as a writing tool for 3D proton lithography. As a result of the experiments, it was proved that the focal point was kept at the same position under changing the kinetic energy but with keeping the kinetic energy ratio constant, which was defined as the ratio of kinetic energy in object side to that in image side for the third acceleration lens. This characteristic of the gas-FIB is a good point to advance the 3D proton lithography changing penetration depth in a sample by varying the beam energy.

  3. Preliminary study on development of 300 Kv compact focused gaseous ion beam system

    International Nuclear Information System (INIS)

    Ohkubo, T.; Ishii, Y.; Kamiya, T.; Miyake, Y.

    2013-01-01

    A new 300 kV compact focused gaseous ion beam (gas-FIB) system with three-stage acceleration lens was constructed at JAEA. The preliminary experiments of formation of the focused gaseous ion beams were carried out to show the availability of the gas-FIB system as a writing tool for 3D proton lithography. As a result of the experiments, it was proved that the focal point was kept at the same position under changing the kinetic energy but with keeping the kinetic energy ratio constant, which was defined as the ratio of kinetic energy in object side to that in image side for the third acceleration lens. This characteristic of the gas-FIB is a good point to advance the 3D proton lithography changing penetration depth in a sample by varying the beam energy.

  4. Estimation of expected short-circuit current levels in and circuit-breaker requirements for the 330 to 750 kV networks of the southern integrated power grid

    Energy Technology Data Exchange (ETDEWEB)

    Krivushkin, L.F.; Gorazeeva, T.F.

    1978-08-01

    Studies were made in order to project the operating levels in the Southern Integrated Power Grid to the year 2000. The short-circuit current levels and, the requirements which circuit breakers will have to meet are estimated. A gradual transition from 330 to 750 kV generation is foreseen, with 330 kV networks remaining only for a purely distribution service. The number of 330 kV line hookups and the number of circuit breakers at nodal points (stations and substations) will not change significantly, they will account for 40% of all circuit breakers installed in 25% of all nodal points. Short-circuit currents are expected to reach the 46 kA level in 750 kV networks and 63 kA (standing wave voltage 1.5 to 2.5 kV/microsecond) in 330 kV networks. These are the ratings of circuit breakers; of the 63 kA ones 150 will be needed by 1980--1990 and 400 by 1990--2000. It will also be eventually worthwhile to install circuit breakers with a 63 kA-750 kV rating.

  5. Low voltage 80 KV to 125 KV electron processors

    International Nuclear Information System (INIS)

    Lauppi, U.V.

    1999-01-01

    The classic electron beam technology made use of accelerating energies in the voltage range of 300 to 800 kV. The first EB processors - built for the curing of coatings - operated at 300 kV. The products to be treated were thicker than a simple layer of coating with thicknesses up to 100g and more. It was only in the beginning of the 1970's that industrial EB processors with accelerating voltages below 300 kV appeared on the market. Our company developed the first commercial electron accelerator without a beam scanner. The new EB machine featured a linear cathode, emitting a shower or 'curtain' of electrons over the full width of the product. These units were much smaller than anv previous EB processors and dedicated to the curing of coatings and other thin layers. ESI's first EB units operated with accelerating voltages between 150 and 200 kV. In 1993 ESI announced the introduction of a new generation of Electrocure. EB processors operating at 120 kV, and in 1998, at the RadTech North America '98 Conference in Chicago, the introduction of an 80 kV electron beam processor under the designation Microbeam LV

  6. Joint Hub Network Development

    NARCIS (Netherlands)

    Cruijssen, F.C.A.M.; Borm, P.E.M.; Dullaert, W.; Hamers, H.J.M.

    2007-01-01

    This paper introduces a framework for joint hub network development. Building a joint physical hub for transhipment of goods is expensive and therefore involves considerable risks for the cooperating companies. In a practical setting, it is unlikely that an entire network will be built at once.

  7. Development of a 400 kV 80 mA Cockcroft-Walton power supply and 12 kW isolation transformer systems for neutron generators

    Science.gov (United States)

    Lu, X.; Chen, S.; Zhang, Y.; Huang, Z.; Ma, Z.; Yao, Z.

    2017-06-01

    A 400 kV 80 mA Cockcroft-Walton power supply driven by 2.5 kHz frequency, and 12 kW isolation transformer systems are developed for an intense DD/DT neutron generator. The design, construction, and testing of the high voltage (HV) power supply and isolation transformer systems are detailed reported. The structure of step-up transformers can make the potential distribution uniform, and auxiliary coils of the isolation transformers can improve the power transmission efficiency significantly. The testing results show that the HV power supply can reach 400 kV, and the isolation transformer systems can withstand 400 kV voltages and its power transmission efficiency is about 98.1%.

  8. Joint Hub Network Development

    OpenAIRE

    Cruijssen, F.C.A.M.; Borm, P.E.M.; Dullaert, W.; Hamers, H.J.M.

    2007-01-01

    This paper introduces a framework for joint hub network development. Building a joint physical hub for transhipment of goods is expensive and therefore involves considerable risks for the cooperating companies. In a practical setting, it is unlikely that an entire network will be built at once. Rather, the partners will have a more cautious attitude and build the hub facilities one-by-one. In the proposed framework, every time a new hub is introduced, partners will have the opportunity to dec...

  9. Development of a 33 kV, 20 A long pulse converter modulator for high average power klystron

    Energy Technology Data Exchange (ETDEWEB)

    Reghu, T.; Mandloi, V.; Shrivastava, Purushottam [Pulsed High Power Microwave Section, Raja Ramanna Centre for Advanced Technology, Indore 452013, M.P. (India)

    2014-05-15

    Research, design, and development of high average power, long pulse modulators for the proposed Indian Spallation Neutron Source are underway at Raja Ramanna Centre for Advanced Technology. With this objective, a prototype of long pulse modulator capable of delivering 33 kV, 20 A at 5 Hz repetition rate has been designed and developed. Three Insulated Gate Bipolar Transistors (IGBT) based switching modules driving high frequency, high voltage transformers have been used to generate high voltage output. The IGBT based switching modules are shifted in phase by 120° with respect to each other. The switching frequency is 25 kHz. Pulses of 1.6 ms pulse width, 80 μs rise time, and 70 μs fall time have been achieved at the modulator output. A droop of ±0.6% is achieved using a simple segmented digital droop correction technique. The total fault energy transferred to the load during fault has been measured by conducting wire burn tests and is found to be within 3.5 J.

  10. Development of a 33 kV, 20 A long pulse converter modulator for high average power klystron

    International Nuclear Information System (INIS)

    Reghu, T.; Mandloi, V.; Shrivastava, Purushottam

    2014-01-01

    Research, design, and development of high average power, long pulse modulators for the proposed Indian Spallation Neutron Source are underway at Raja Ramanna Centre for Advanced Technology. With this objective, a prototype of long pulse modulator capable of delivering 33 kV, 20 A at 5 Hz repetition rate has been designed and developed. Three Insulated Gate Bipolar Transistors (IGBT) based switching modules driving high frequency, high voltage transformers have been used to generate high voltage output. The IGBT based switching modules are shifted in phase by 120° with respect to each other. The switching frequency is 25 kHz. Pulses of 1.6 ms pulse width, 80 μs rise time, and 70 μs fall time have been achieved at the modulator output. A droop of ±0.6% is achieved using a simple segmented digital droop correction technique. The total fault energy transferred to the load during fault has been measured by conducting wire burn tests and is found to be within 3.5 J

  11. Development of a 33 kV, 20 A long pulse converter modulator for high average power klystron

    Science.gov (United States)

    Reghu, T.; Mandloi, V.; Shrivastava, Purushottam

    2014-05-01

    Research, design, and development of high average power, long pulse modulators for the proposed Indian Spallation Neutron Source are underway at Raja Ramanna Centre for Advanced Technology. With this objective, a prototype of long pulse modulator capable of delivering 33 kV, 20 A at 5 Hz repetition rate has been designed and developed. Three Insulated Gate Bipolar Transistors (IGBT) based switching modules driving high frequency, high voltage transformers have been used to generate high voltage output. The IGBT based switching modules are shifted in phase by 120° with respect to each other. The switching frequency is 25 kHz. Pulses of 1.6 ms pulse width, 80 μs rise time, and 70 μs fall time have been achieved at the modulator output. A droop of ±0.6% is achieved using a simple segmented digital droop correction technique. The total fault energy transferred to the load during fault has been measured by conducting wire burn tests and is found to be within 3.5 J.

  12. Space Network Devices Developed

    Science.gov (United States)

    Jones, Robert E.

    2004-01-01

    The NASA Glenn Research Center through a contract with Spectrum Astro, Inc., has been developing space network hardware as an enabling technology using open systems interconnect (OSI) standards for space-based communications applications. The OSI standard is a well-recognized layered reference model that specifies how data should be sent node to node in a communications network. Because of this research and technology development, a space-qualifiable Ethernet-based network interface card (similar to the type found in a networked personal computer) and the associated four-port hub were designed and developed to flight specifications. During this research and development, there also have been many lessons learned for determining approaches for migrating existing spacecraft architectures to an OSI-network-based platform. Industry has recognized the benefits of targeting hardware developed around OSI standards such as Transmission Control Protocol/Internet Protocol (TCP/IP) or similar protocols for use in future generations of space communication systems. Some of these tangible benefits include overall reductions in mission schedule and cost and in system complexity. This development also brings us a step closer to the realization of a principal investigator on a terrestrial Internet site being able to interact with space platform assets in near real time. To develop this hardware, Spectrum Astro first conducted a technology analysis of alternatives study. For this analysis, they looked at the features of three protocol specifications: Ethernet (IEEE 802.3), Firewire (IEEE 1394), and Spacewire (IEEE 1355). A thorough analysis was performed on the basis of criteria such as current protocol performance and suitability for future space applications. Spectrum Astro also projected future influences such as cost, hardware and software availability, throughput performance, and integration procedures for current and transitive space architectures. After a thorough analysis

  13. RESEARCH OF THE INFLUENCE OF VARIOUS FACTORS ON THE ACCURACY OF DETERMINING OF PARAMETERS AND PLACE OF INSULATION DAMAGE IN THE ELECTRIC NETWORKS OF 6 TO 35 KV

    Directory of Open Access Journals (Sweden)

    Naraeva R.R

    2013-12-01

    Full Text Available The present paper is devoted to the research of the method for determining the parameters and plot of insulation damage in the networks of 6 to 35 kV with isolated neutral on the basis of measuring the operating parameters of the network. In the considered three-phase circuit with a symmetric source of EMF and symmetric loading there was a damage of insulation in one of the phases. The calculations are carried out for the transmission line equivalent circuit with a branch line by means of node-potential method. An investigation of the influence of the magnitude of insulation conductivity in the place of damage of different sections of the network upon the accuracy of determining the insulation conductivity is conducted using the data from digital models. The research of this method is performed by advancing hypotheses about the place of damage and by considering the influence of the multiplicity of increasing insulation conductivity of the damaged section and accuracy class of measuring devices.

  14. Stability and voltage rise at operating frequency in ehv networks at 500 to 700 kV

    Energy Technology Data Exchange (ETDEWEB)

    Glavitsch, H

    1964-01-01

    The importance of stability is stressed in the case of long transmission lines interconnecting different systems. To achieve better stability one requires improvement of network stability and generator stability. The methods of excitation and electric braking for improving the dynamic stability of generators are described. The stability of two networks connected by a line is examined theoretically. The various causes of voltage rises at operating frequency, e.g., loading, load dropping etc., and the usual types of transients are discussed.

  15. Using of explosive technologies for development of a compact current-limiting device for operation on 110 kV class systems

    Science.gov (United States)

    Shurupov, A. V.; Shurupov, M. A.; Kozlov, A. A.; Kotov, A. V.

    2016-11-01

    This paper considers the possibility of creating on new physical principles a highspeed current-limiting device (CLD) for the networks with voltage of 110 kV, namely, on the basis of the explosive switching elements. The device is designed to limit the steady short-circuit current to acceptable values for the time does not exceed 3 ms at electric power facilities. The paper presents an analysis of the electrical circuit of CLD. The main features of the scheme are: a new high-speed switching element with high regenerating voltage; fusible switching element that enables to limit the overvoltage after sudden breakage of network of the explosive switch; non-inductive resistor with a high heat capacity and a special reactor with operating time less than 1 s. We analyzed the work of the CLD with help of special software PSPICE, which is based on the equivalent circuit of single-phase short circuit to ground in 110 kV network. Analysis of the equivalent circuit operation CLD shows its efficiency and determines the CLD as a perspective direction of the current-limiting devices of new generation.

  16. Using of explosive technologies for development of a compact current-limiting device for operation on 110 kV class systems

    International Nuclear Information System (INIS)

    Shurupov, A V; Shurupov, M A; Kozlov, A A; Kotov, A V

    2016-01-01

    This paper considers the possibility of creating on new physical principles a highspeed current-limiting device (CLD) for the networks with voltage of 110 kV, namely, on the basis of the explosive switching elements. The device is designed to limit the steady short-circuit current to acceptable values for the time does not exceed 3 ms at electric power facilities. The paper presents an analysis of the electrical circuit of CLD. The main features of the scheme are: a new high-speed switching element with high regenerating voltage; fusible switching element that enables to limit the overvoltage after sudden breakage of network of the explosive switch; non-inductive resistor with a high heat capacity and a special reactor with operating time less than 1 s. We analyzed the work of the CLD with help of special software PSPICE, which is based on the equivalent circuit of single-phase short circuit to ground in 110 kV network. Analysis of the equivalent circuit operation CLD shows its efficiency and determines the CLD as a perspective direction of the current-limiting devices of new generation. (paper)

  17. Network development plan 1995

    International Nuclear Information System (INIS)

    Anon.

    1995-11-01

    Network plan 1995 concerns several strategic problems, among others environmental policy of power transmission lines. Possibilities of restructuring aerial cable network are described. The state of the existing systems and plans for new network systems are presented. (EG)

  18. Implementation of a Single-Phase SST for the Interface between a 13.2 kV MVAC Network and a 750 V Bipolar DC Distribution

    Directory of Open Access Journals (Sweden)

    Hyeok-Jin Yun

    2018-05-01

    Full Text Available This paper presents the implementation of a single-phase solid-state transformer (SST for the interface between a 13.2 kV medium voltage alternative current (MVAC network and a 750 V bipolar DC distribution. The SST has ten cascaded subunits in consideration of the device rating and modulation index (MI. Each subunit consists of an AC/DC stage and a DC/DC stage with a high frequency isolated transformer (HFIT. The AC/DC stage consists of cascaded H-bridges (CHBs to cope with the MVAC. The DC/DC stage employs a triple active bridge (TAB converter for bipolar DC distribution. Topology analysis and controller design for this specific structure are discussed. In addition, the insulation of HFIT used in DC/DC converters is also discussed. A simple balancing controller at the AC/DC stage and a current sharing controller at the DC/DC stage are used to prevent DC-link voltage unbalance caused by the cascaded structure. The discussions are validated using a 150 kW single-phase 21-level SST prototype at the laboratory level.

  19. 250 kV aim for hvdc valves

    Energy Technology Data Exchange (ETDEWEB)

    1966-06-01

    Development now being carried out by ASEA is aimed at increasing the normal operating voltage for a mercury arc valve to 250 kV dc. The maximum direct voltage per valve group, with one valve in each arm of the bridge, is 125 kV for equipment already in operation in New Zealand, Japan, and Konti Scan. Valves for 130 kV and 133 kV operation are under construction for the Vancouver and the Pacific Intertie 1 links.

  20. The anticonvulsant retigabine suppresses neuronal Kv2-mediated currents

    DEFF Research Database (Denmark)

    Stas, Jeroen I; Bocksteins, Elke; Jensen, Camilla S

    2016-01-01

    Enhancement of neuronal M-currents, generated through KV7.2-KV7.5 channels, has gained much interest for its potential in developing treatments for hyperexcitability-related disorders such as epilepsy. Retigabine, a KV7 channel opener, has proven to be an effective anticonvulsant and has recently...

  1. Ten-Year Network Development Plan - 2015 edition, executive summary

    International Nuclear Information System (INIS)

    2016-01-01

    Complying with the European and French laws, each year, RTE prepares and publicizes a Ten-Year Network Development Plan (NDP) to meet the expectations of its stakeholders and customers. The NDP lists the network development projects that RTE plans to complete and commission over a 3-year period and presents the main power transmission infrastructure work envisaged for the next Ten-years. Beyond, it outlines the possible network adaptation needs for a variety of energy transition scenarios. Over the next 10 years, the network investments will make it possible to: - Meet the goals of the Regional Climate Air Energy Plans, - Create 4 GW of extra offshore wind generation integration capacity and 10 GW of additional interconnection capacity, 2/3 more than the current capacity, - Enable the development of economically and demographically dynamic areas, with safe and high-standard electricity supply. In the coming decade, RTE plans: - 1,200 km of new underground and sub-sea DC links, along with their associated converter stations; - 600 km of existing equipment upgrades or new overhead 400 kV AC circuits substituting existing power lines. - and, at the same time, nearly 900 km of underground lines and just over 400 km of overhead 225 kV AC lines should be built. 400 projects are listed in this NDP: - 21% of the operations are on overhead lines (for 3/4 new lines or upgrade and for 1/4 dismantling of existing assets) - 27% concern new underground lines; - 52% on substation adaptations (about 20 new RTE substations and 100 new customer substations connected). Globally, nearly 80% of the network is developed underground or sub-sea. This edition of the Network Development plan is further enriched. In particular, it explains more thoroughly the link between the integration of renewable energy and the entailed development of the transmission network. It also provides a focus on smart grids. This edition relies on mid and long term scenarios describing the evolution of the

  2. KV7 potassium channels

    DEFF Research Database (Denmark)

    Stott, Jennifer B; Jepps, Thomas Andrew; Greenwood, Iain A

    2014-01-01

    Potassium channels are key regulators of smooth muscle tone, with increases in activity resulting in hyperpolarisation of the cell membrane, which acts to oppose vasoconstriction. Several potassium channels exist within smooth muscle, but the KV7 family of voltage-gated potassium channels have been...

  3. Network tomography : recent developments

    NARCIS (Netherlands)

    Castro, R.M.; Coates, M.; Liang, G.; Nowak, R.; Yu, B.

    2004-01-01

    Today’s Internet is a massive, distributed network which continues to explode in size as e-commerce and related activities grow. The heterogeneous and largely unregulated structure of the Internet renders tasks such as dynamic routing, optimized service provision, service level verification and

  4. 735 kV circuit breakers for ehv

    Energy Technology Data Exchange (ETDEWEB)

    1966-01-01

    French manufacturers have been studying the design of high and extra high voltage circuit breakers for several years. The two techniques they used were the low volume oil and the air pressure technique. These have permitted the development of a type gear capable of solving problems all over the world as they arose following the development of electrical energy transmission at extra high voltage as well as high short circuit power. Today, the air pressure solution is used in new constructions such as the 735 kV transmission network in Canada.

  5. Power cables with extruded insulation and their accessories for rated voltages from 1 kV (Um = 1,2 kV) up to 30 kV (Um = 36 kV) : Part 2: cables for rated voltages from 6 kV (Um = 7,2 kV) up to 30 kV (Um = 36 kV)

    CERN Document Server

    International Electrotechnical Commission. Geneva

    2005-01-01

    Power cables with extruded insulation and their accessories for rated voltages from 1 kV (Um = 1,2 kV) up to 30 kV (Um = 36 kV) : Part 2: cables for rated voltages from 6 kV (Um = 7,2 kV) up to 30 kV (Um = 36 kV)

  6. First 735 kV transmission, Manicouagan, Montreal

    Energy Technology Data Exchange (ETDEWEB)

    Cahill, L

    1964-11-01

    The 735 kV transmission network of Hydro Quebec is described giving reasons for choice of voltage, stability factors level of insulation, disposition of conductors, insulators, equipment used and state of readiness of the project.

  7. APPLICATION OF SSSC TO THE 330kV NIGERIAN ...

    African Journals Online (AJOL)

    HOD

    2,3 DEPARTMENT OF ELECTRONIC AND ELECTRICAL ENGR., FEDERAL POLYTECHNIC EDE, ... Longitudinal power systems of Nigerian 330 kV transmission network have steady-state ..... C tr ller ” Unpublish Master Thesis Submitted to.

  8. Networking systems design and development

    CERN Document Server

    Chao, Lee

    2009-01-01

    Effectively integrating theory and hands-on practice, Networking Systems Design and Development provides students and IT professionals with the knowledge and skills needed to design, implement, and manage fully functioning network systems using readily available Linux networking tools. Recognizing that most students are beginners in the field of networking, the text provides step-by-step instruction for setting up a virtual lab environment at home. Grounded in real-world applications, this book provides the ideal blend of conceptual instruction and lab work to give students and IT professional

  9. Three-phase shots and monopolar reclose in the core network of 400 kV of the Area de Control Occidental of CFE and Its normal probability of occurrence; Disparos trifasicos y de recierre monopolar en la red troncal de 400 kV del area de control occidental, CFE, y su probabilidad normal de ocurrencia

    Energy Technology Data Exchange (ETDEWEB)

    Narvaez Perez, Camilo; Garcia Conejo, Dante Aristoteles [Comision Federal de Electricidad, Centro Nacional de Control de Energia, Area de Control Occidental, Zapopan, Jalisco (Mexico)]. E-mail: camilo.narvaez@cfe.gob.mx; camilo.narvaez@univa.mx; Ramirez Peredo, Patricia [Universidad de Guadalajara, Guadalajara, Jalisco (Mexico)]. E-mail: patyrape@hotmail.com; Blanco Gomez, Cesar Eduardo [Comision Federal de Electricidad, Centro Nacional de Control de Energia, Area de Control Occidental, Zapopan, Jalisco (Mexico)

    2013-03-15

    The growing power demand of users, who make loads of power systems, causes the components of such systems operating near its operating limits. And the transmission line, being the most common component in these, requires a thorough analysis in regard to the probability of three-phase shots and monopolars reclosing, considering thunderstorms, the demand system time, the flows circulating in lines, maintenance on other lines and other imponderantes. This research analyzes the normal probability of occurrence of shots in the 400 kV core network of the Area de Control Occidental, CFE and its impact on studies conducted prior to the maintenance. We intend to use the methodology in the Comision Federal de Electricidad and results can be validated with data from previous years, based on a pseudo shots forecast in a given period. [Spanish] La creciente demanda de energia electrica de los usuarios que componen las cargas de los sistemas electricos de potencia, provoca que los componentes de dichos sistemas funcionen cerca de sus limites operativos. Y la linea de transmision, al ser el componente mas comun en estos, requiere de un analisis minucioso en lo que respecta a la probabilidad de disparos trifasicos y recierres monopolares, considerando tormentas electricas, la demanda horaria del sistema, los flujos que circulan en las lineas, los mantenimientos en las demas lineas y demas imponderantes. En esta investigacion se analiza la probabilidad normal de ocurrencia de disparos en la red troncal de 400 kV del Area de Control Occidental y su impacto en los estudios que se realizan previos a los mantenimientos. Se pretende utilizar la metodologia en la Comision Federal de Electricidad, y los resultados pueden ser validados con datos de los anos anteriores, ya que se hace un pseudo pronostico de disparos en un periodo dado.

  10. Open development networked innovations in international development

    CERN Document Server

    Reilly, Katherine M A

    2014-01-01

    The emergence of open networked models made possible by digital technology has the potential to transform international development. Open network structures allow people to come together to share information, organize, and collaborate. Open development harnesses this power, to create new organizational forms and improve people's lives; it is not only an agenda for research and practice but also a statement about how to approach international development. In this volume, experts explore a variety of applications of openness, addressing challenges as well as opportunities. Open development requires new theoretical tools that focus on real world problems, consider a variety of solutions, and recognize the complexity of local contexts. After exploring the new theoretical terrain, the book describes a range of cases in which open models address such specific development issues as biotechnology research, improving education, and access to scholarly publications. Contributors then examine tensions between open model...

  11. Developing Strategies for Networked Education.

    Science.gov (United States)

    Peregoy, Richard; Kroder, Stanley

    2000-01-01

    Assesses the strengths, weaknesses, opportunities and threats (SWOT) of the distance learning approach to education, and discusses how one institution, the University of Dallas Graduate School of Management, has developed a progressively expanding networked distance education program. Includes quotes from three students that suggest the quality of…

  12. Step-by-step application methodology in practical KEPCO 22.9kV bus-bar system

    International Nuclear Information System (INIS)

    Yoon, Jae-young; Lee, Seung-yeol

    2010-01-01

    With the increase of power demand and the progress of power industry deregulation, the transmission and distribution systems will have more complicated problems by the influence of curtailing investment and the NIMBY phenomena in overall power systems. [1-2] It is expected that the route length per MW demand of South Korea will decrease gradually from 0.6[C-km/MW] to 0.53[C-km/MW] in 2010.[3] This comes up to a real serious problem from system planning and operation viewpoints. HTS technologies related to power system have properties to solve these complex transmission and distribution constraints, especially for metropolitan area, in the future. As the HTS technology has developed, the HTS cable technology can be the most effective alternative to solve the future expected power network constraints. This paper describes the application methodology of developing 22.9kV HTS cable by CAST for practical distribution system. 22.9kV HTS cable under development with step-by-step application methodology can substitute the existing and planning conventional 154kV cable.[4-5] If this scheme is applied, part of downtown 154kV substation of metropolitan city such as Seoul can be changed into 22.9kV switching station. Additionally, it can give huge economic, environmental benefits to all of the concerned authorities.

  13. Internal services simulation control in 220/110kV power transformer station Mintia

    Science.gov (United States)

    Ciulica, D.; Rob, R.

    2018-01-01

    The main objectives in developing the electric transport and distribution networks infrastructure are satisfying the electric energy demand, ensuring the continuity of supply to customers, minimizing electricity losses in the transmission and distribution networks of public interest. This paper presents simulations in functioning of the internal services system 400/230 V ac in the 220/110 kV power transformer station Mintia. Using simulations in Visual Basic, the following premises are taken into consideration. All the ac consumers of the 220/110 kV power transformer station Mintia will be supplied by three 400/230 V transformers for internal services which can mutual reserve. In case of damaging at one transformer, the others are able to assume the entire consumption using automatic release of reserves. The simulation program studies three variants in which the continuity of supply to customers are ensured. As well, by simulations, all the functioning situations are analyzed in detail.

  14. Recent developments in Lambda networking

    Science.gov (United States)

    de Laat, C.; Grosso, P.

    About 6 years ago the first baby-steps were made on opening up dark fiber and DWDM infrastructure for direct use by ISP's after the transformation of the old style Telecom sector into a market driven business. Since then Lambda workshops, community groups like GLIF and a number of experiments have led to many implementations of hybrid national research and education networks and lightpath-based circuit exchanges as pioneered by SURFnet in GigaPort and NetherLight in collaboration with StarLight in Chicago and Canarie in Canada. This article looks back on those developments, describes some current open issues and research developments and proposes a concept of terabit networking.

  15. Proposal to negotiate an amendment to an existing contract for the supply of four additional low-noise Thyristor-Controlled Reactor coils for a new Static VAR Compensator on the 18 kV electrical network on the Meyrin site

    CERN Document Server

    2017-01-01

    Proposal to negotiate an amendment to an existing contract for the supply of four additional low-noise Thyristor-Controlled Reactor coils for a new Static VAR Compensator on the 18 kV electrical network on the Meyrin site

  16. Development of PSpice modeling platform for 10 kV/100 A SiC MOSFET power module

    DEFF Research Database (Denmark)

    Martins, Joäo Pedro Rodrigues; Nawaz, Muhammad; Ilves, Kalle

    2017-01-01

    was implemented based on the already established McNutt Hefner model originally developed for discrete single-die based SiC-MOSFETs. The proposed model has been verified both with static and dynamic experimental data and at different temperatures. Moreover, the energy loss assessment has been performed...... for a variety of operating parameters (e.g., stray inductance, gate resistance), different load current and supply voltages. The model was also verified with parallel connection of several power modules in order to predict the current unbalance as a result of various parasitic elements in the test circuit....... The developed model has been further extended to study the electro-thermal behaviour under short circuit with accurate predictability, and validated with the experimental data. Finally, the operational robustness of the model was judged by simulating an arbitrary Buck, and Boost converter where the converter...

  17. Major Refit for CERN's 400 kV Substation

    CERN Multimedia

    2001-01-01

    The 400 kV substation on the Prévessin site brings in the electricity that powers CERN's accelerators and the majority of the Laboratory's installations. It was originally built in the 1970s for the SPS, and is one of only five privately owned 400 kV sub-stations in France. Three of the others belong to the national railway company, SNCF, supplying the Paris-Marseilles TGV line, the other is at the Cadarache research centre near mouth of the Rhone. After nearly thirty years of service, CERN's substation has just undergone a complete overhaul. The new main 18 kV switchboard for the SPS pulsed network. The electricity supply for the original Prévessin substation was from the 400 kV EDF network, delivered through three 90 MW transformers at 18 kV to the SPS pulsed network, With the arrival of LEP, two 110 MW transformers were added to supply the new accelerator. Now, as CERN gears up for the LHC, additional pulsed power capacity is needed to supply the transfer lines carrying protons from...

  18. Mechanosensitive gating of Kv channels.

    Directory of Open Access Journals (Sweden)

    Catherine E Morris

    Full Text Available K-selective voltage-gated channels (Kv are multi-conformation bilayer-embedded proteins whose mechanosensitive (MS Popen(V implies that at least one conformational transition requires the restructuring of the channel-bilayer interface. Unlike Morris and colleagues, who attributed MS-Kv responses to a cooperative V-dependent closed-closed expansion↔compaction transition near the open state, Mackinnon and colleagues invoke expansion during a V-independent closed↔open transition. With increasing membrane tension, they suggest, the closed↔open equilibrium constant, L, can increase >100-fold, thereby taking steady-state Popen from 0→1; "exquisite sensitivity to small…mechanical perturbations", they state, makes a Kv "as much a mechanosensitive…as…a voltage-dependent channel". Devised to explain successive gK(V curves in excised patches where tension spontaneously increased until lysis, their L-based model falters in part because of an overlooked IK feature; with recovery from slow inactivation factored in, their g(V datasets are fully explained by the earlier model (a MS V-dependent closed-closed transition, invariant L≥4. An L-based MS-Kv predicts neither known Kv time courses nor the distinctive MS responses of Kv-ILT. It predicts Kv densities (hence gating charge per V-sensor several-fold different from established values. If opening depended on elevated tension (L-based model, standard gK(V operation would be compromised by animal cells' membrane flaccidity. A MS V-dependent transition is, by contrast, unproblematic on all counts. Since these issues bear directly on recent findings that mechanically-modulated Kv channels subtly tune pain-related excitability in peripheral mechanoreceptor neurons we undertook excitability modeling (evoked action potentials. Kvs with MS V-dependent closed-closed transitions produce nuanced mechanically-modulated excitability whereas an L-based MS-Kv yields extreme, possibly excessive

  19. Technological Developments in Networking, Education and Automation

    CERN Document Server

    Elleithy, Khaled; Iskander, Magued; Kapila, Vikram; Karim, Mohammad A; Mahmood, Ausif

    2010-01-01

    "Technological Developments in Networking, Education and Automation" includes a set of rigorously reviewed world-class manuscripts addressing and detailing state-of-the-art research projects in the following areas: Computer Networks: Access Technologies, Medium Access Control, Network architectures and Equipment, Optical Networks and Switching, Telecommunication Technology, and Ultra Wideband Communications. Engineering Education and Online Learning: including development of courses and systems for engineering, technical and liberal studies programs; online laboratories; intelligent

  20. Deletion of the Kv2.1 delayed rectifier potassium channel leads to neuronal and behavioral hyperexcitability

    Science.gov (United States)

    Speca, David J.; Ogata, Genki; Mandikian, Danielle; Bishop, Hannah I.; Wiler, Steve W.; Eum, Kenneth; Wenzel, H. Jürgen; Doisy, Emily T.; Matt, Lucas; Campi, Katharine L.; Golub, Mari S.; Nerbonne, Jeanne M.; Hell, Johannes W.; Trainor, Brian C.; Sack, Jon T.; Schwartzkroin, Philip A.; Trimmer, James S.

    2014-01-01

    The Kv2.1 delayed rectifier potassium channel exhibits high-level expression in both principal and inhibitory neurons throughout the central nervous system, including prominent expression in hippocampal neurons. Studies of in vitro preparations suggest that Kv2.1 is a key yet conditional regulator of intrinsic neuronal excitability, mediated by changes in Kv2.1 expression, localization and function via activity-dependent regulation of Kv2.1 phosphorylation. Here we identify neurological and behavioral deficits in mutant (Kv2.1−/−) mice lacking this channel. Kv2.1−/− mice have grossly normal characteristics. No impairment in vision or motor coordination was apparent, although Kv2.1−/− mice exhibit reduced body weight. The anatomic structure and expression of related Kv channels in the brains of Kv2.1−/− mice appears unchanged. Delayed rectifier potassium current is diminished in hippocampal neurons cultured from Kv2.1−/− animals. Field recordings from hippocampal slices of Kv2.1−/− mice reveal hyperexcitability in response to the convulsant bicuculline, and epileptiform activity in response to stimulation. In Kv2.1−/− mice, long-term potentiation at the Schaffer collateral – CA1 synapse is decreased. Kv2.1−/− mice are strikingly hyperactive, and exhibit defects in spatial learning, failing to improve performance in a Morris Water Maze task. Kv2.1−/− mice are hypersensitive to the effects of the convulsants flurothyl and pilocarpine, consistent with a role for Kv2.1 as a conditional suppressor of neuronal activity. Although not prone to spontaneous seizures, Kv2.1−/− mice exhibit accelerated seizure progression. Together, these findings suggest homeostatic suppression of elevated neuronal activity by Kv2.1 plays a central role in regulating neuronal network function. PMID:24494598

  1. Networks as Tools for Sustainable Urban Development

    DEFF Research Database (Denmark)

    Jensen, Jesper Ole; Tollin, Nicola

    will be discussed through a case study of a Danish municipal network on Sustainable Development, Dogme 20001. This network has become quite successful in terms of learning and innovation, committing actors, and influencing local policies, to a larger extent than other SUD-networks the municipalities are involved in....... By applying the GREMI2-theories of “innovative milieux” (Aydalot, 1986; Camagni, 1991) to the case study, we will suggest some reasons for the benefits achieved by the Dogme-network, compared to other networks. This analysis will point to the existence of an “innovative milieu” on sustainability within......Due to the increasing number of networks related to sustainable development (SUD) the paper focuses on understanding in which way networks can be considered useful tools for sustainable urban development, taking particularly into consideration the networks potential of spreading innovative policies...

  2. SU-F-T-667: Development and Validation of Dose Calculation for An Open-Source KV Treatment Planning System for Small Animal Radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Prajapati, S [M D Anderson Cancer Center, Houston, TX (United States); Mo, X; Bednarz, B; Lawless, M; Hammer, C; Jeraj, R; Mackie, T [University of Wisconsin- Madison, Madison, WI (United States); Flynn, R [University of Iowa Hospitals and Clinics, Iowa City, IA (United States); Westerly, D [University of Colorado Denver, Aurora, CO (United States)

    2016-06-15

    Purpose: An open-source, convolution/superposition based kV-treatment planning system(TPS) was developed for small animal radiotherapy from previously existed in-house MV-TPS. It is flexible and applicable to both step and shoot and helical tomotherapy treatment delivery. For initial commissioning process, the dose calculation from kV-TPS was compared with measurements and Monte Carlo(MC) simulations. Methods: High resolution, low energy kernels were simulated using EGSnrc user code EDKnrc, which was used as an input in kV-TPS together with MC-simulated x-ray beam spectrum. The Blue Water™ homogeneous phantom (with film inserts) and heterogeneous phantom (with film and TLD inserts) were fabricated. Phantom was placed at 100cm SSD, and was irradiated with 250 kVp beam for 10mins with 1.1cm × 1.1cm open field (at 100cm) created by newly designed binary micro-MLC assembly positioned at 90cm SSD. Gafchromic™ EBT3 film was calibrated in-phantom following AAPM TG-61 guidelines, and were used for measurement at 5 different depths in phantom. Calibrated TLD-100s were obtained from ADCL. EGS and MNCP5 simulation were used to model experimental irradiation set up calculation of dose in phantom. Results: Using the homogeneous phantom, dose difference between film and kV-TPS was calculated: mean(x)=0.9%; maximum difference(MD)=3.1%; standard deviation(σ)=1.1%. Dose difference between MCNP5 and kV-TPS was: x=1.5%; MD=4.6%; σ=1.9%. Dose difference between EGS and kV-TPS was: x=0.8%; MD=1.9%; σ=0.8%. Using the heterogeneous phantom, dose difference between film and kV-TPS was: x=2.6%; MD=3%; σ=1.1%; and dose difference between TLD and kV-TPS was: x=2.9%; MD=6.4%; σ=2.5%. Conclusion: The inhouse, open-source kV-TPS dose calculation system was comparable within 5% of measurements and MC simulations in both homogeneous and heterogeneous phantoms. The dose calculation system of the kV-TPS is validated as a part of initial commissioning process for small animal radiotherapy

  3. Open Development : Networked Innovations in International ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Open Development : Networked Innovations in International Development. Couverture du livre Open Development: Networked Innovations in International Development. Directeur(s):. Matthew L. Smith et Katherine M. A. Reilly. Maison(s) d'édition: The MIT Press, CRDI. 12 décembre 2013. ISBN : 9780262525411.

  4. Developing Personal Network Business Models

    DEFF Research Database (Denmark)

    Saugstrup, Dan; Henten, Anders

    2006-01-01

    The aim of the paper is to examine the issue of business modeling in relation to personal networks, PNs. The paper builds on research performed on business models in the EU 1ST MAGNET1 project (My personal Adaptive Global NET). The paper presents the Personal Network concept and briefly reports...

  5. HVDC transmission preferred to 750 kV ac

    Energy Technology Data Exchange (ETDEWEB)

    1965-06-25

    It is unlikely that there will be a need in Britain for ac transmission voltages above 400 kV. But with the growing load density in the large conurbations with no possibility of local generation, high voltage dc transmission is likely to be most useful. It was concluded that by 1971 the 400 kV supergrid would be nation-wide and 6,200 circuit miles should be in service. With the expansion to accommodate the large new generating stations, the 400 kV supergrid would become an extremely high power distribution network rather than a transmission system. A higher voltage for transmission is outside the rational limit of speculation for a country the size of Britain.

  6. Information Network on Rural Development (INRD), Bangladesh.

    Science.gov (United States)

    Wanasundra, Leelangi

    1994-01-01

    Discusses information networking in Bangladesh and describes the formation of the Information Network on Rural Development (INRD) which was initiated by the Center on Integrated Rural Development for Asia and the Pacific (CIRDAP). Organization, membership, activities, participation, and finance are examined. (four references) (LRW)

  7. From pan-reactive KV7 channel opener to subtype selective opener/inhibitor by addition of a methyl group.

    Directory of Open Access Journals (Sweden)

    Sigrid Marie Blom

    Full Text Available The voltage-gated potassium channels of the KV7 family (KV7.1-5 play important roles in controlling neuronal excitability and are therefore attractive targets for treatment of CNS disorders linked to hyperexcitability. One of the main challenges in developing KV7 channel active drugs has been to identify compounds capable of discriminating between the neuronally expressed subtypes (KV7.2-5, aiding the identification of the subunit composition of KV7 currents in various tissues, and possessing better therapeutic potential for particular indications. By taking advantage of the structure-activity relationship of acrylamide KV7 channel openers and the effects of these compounds on mutant KV7 channels, we have designed and synthesized a novel KV7 channel modulator with a unique profile. The compound, named SMB-1, is an inhibitor of KV7.2 and an activator of KV7.4. SMB-1 inhibits KV7.2 by reducing the current amplitude and increasing the time constant for the slow component of the activation kinetics. The activation of KV7.4 is seen as an increase in the current amplitude and a slowing of the deactivation kinetics. Experiments studying mutant channels with a compromised binding site for the KV7.2-5 opener retigabine indicate that SMB-1 binds within the same pocket as retigabine for both inhibition of KV7.2 and activation of KV7.4. SMB-1 may serve as a valuable tool for KV7 channel research and may be used as a template for further design of better subtype selective KV7 channel modulators. A compound with this profile could hold novel therapeutic potential such as the treatment of both positive and cognitive symptoms in schizophrenia.

  8. Analisa Penggunaan Recloser untuk Pengaman Arus Lebih pada Jaringan Distribusi 20 Kv Gardu Induk Garuda Sakti

    OpenAIRE

    Putra, Ario; Firdaus, Firdaus

    2017-01-01

    PT.PLN: 20 kV network substations Garuda Sakti, frequently interference, one of interferences is the short-circuit current. To install equipment to include Recloser. This paper discuss the analysisof the use Recloser on distribution network 20 kV, this paper also be simulated using the software ETAP 12.6 which will feature some of the parameters for comparison of calculations and data thatalready exists in PLN, with two parameters, short circuit and coordination Recloser with overcurrent rela...

  9. Indicators for establishing SME product development networks

    NARCIS (Netherlands)

    Post, G.J.J.; Hop, L.; Aken, van J.E.

    2001-01-01

    The results of research into SME product development networks are presented. The paper provides insight to the process of establishing such networks and the use of indicators in the design and monitoring of this process. It is based on five extensive case studies and in addition on several in-depth

  10. Learning Networks for Professional Development & Lifelong Learning

    NARCIS (Netherlands)

    Brouns, Francis; Sloep, Peter

    2009-01-01

    Brouns, F., & Sloep, P. B. (2009). Learning Networks for Professional Development & Lifelong Learning. Presentation of the Learning Network Programme for a Korean delegation of Chonnam National University and Dankook University (researchers dr. Jeeheon Ryu and dr. Minjeong Kim and a Group of PhD and

  11. Developing aircraft photonic networks for airplane systems

    DEFF Research Database (Denmark)

    White, Henry J.; Brownjohn, Nick; Baptista, João

    2013-01-01

    Achieving affordable high speed fiber optic communication networks for airplane systems has proved to be challenging. In this paper we describe a summary of the EU Framework 7 project DAPHNE (Developing Aircraft Photonic Networks). DAPHNE aimed to exploit photonic technology from terrestrial...

  12. The transient outward current in mice lacking the potassium channel gene Kv1.4

    Science.gov (United States)

    London, Barry; Wang, Dao W; Hill, Joseph A; Bennett, Paul B

    1998-01-01

    The transient outward current (Ito) plays a prominent role in the repolarization phase of the cardiac action potential. Several K+ channel genes, including Kv1.4, are expressed in the heart, produce rapidly inactivating currents when heterologously expressed, and may be the molecular basis of Ito.We engineered mice homozygous for a targeted disruption of the K+ channel gene Kv1.4 and compared Ito in wild-type (Kv1.4+/+), heterozygous (Kv1.4+/-) and homozygous ‘knockout’ (Kv1.4−/−) mice. Kv1.4 RNA was truncated in Kv1.4−/− mice and protein expression was absent.Adult myocytes isolated from Kv1.4+/+, Kv1.4+/− and Kv1.4−/− mice had large rapidly inactivating outward currents. The peak current densities at 60 mV (normalized by cellular capacitance, in pA pF−1; means ± s.e.m.) were 53.8 ± 5.3, 45.3 ± 2.2 and 44.4 ± 2.8 in cells from Kv1.4+/+, Kv1.4+/− and Kv1.4−/− mice, respectively (P mice.The voltage dependence and time course of inactivation were not changed by targeted disruption of Kv1.4. The mean best-fitting V½ (membrane potential at 50 % inactivation) values for myocytes from Kv1.4 +/+, Kv1.4+/− and Kv1.4−/− mice were -53.5 ± 3.7, -51.1 ± 2.6 and -54.2 ± 2.4 mV, respectively. The slope factors (k) were -10.1 ± 1.4, -8.8 ± 1.4 and -9.5 ± 1.2 mV, respectively. The fast time constants for development of inactivation at -30 mV were 27.8 ± 2.2, 26.2 ± 5.1 and 19.6 ± 2.1 ms in Kv1.4+/+, Kv1.4+/− and Kv1.4−/− myocytes, respectively. At +30 mV, they were 35.5 ± 2.6, 30.0 ± 2.1 and 28.7 ± 1.6 ms, respectively. The time constants for the rapid phase of recovery from inactivation at -80 mV were 32.5 ± 8.2, 23.3 ± 1.8 and 39.0 ± 3.7 ms, respectively.Nearly the entire inactivating component as well as more than 60 % of the steady-state outward current was eliminated by 1 mm 4-aminopyridine in Kv1.4+/+, Kv1.4+/− and Kv1.4−/− myocytes.Western blot analysis of heart membrane extracts showed no significant

  13. Developing networks to support science teachers work

    DEFF Research Database (Denmark)

    Sillasen, Martin Krabbe; Valero, Paola

    2012-01-01

    In educational research literature constructing networks among practitioners has been suggested as a strategy to support teachers’ professional development (Huberman, 1995; Jackson & Temperley, 2007; Van Driel, Beijaard, & Verloop, 2001). The purpose of this paper is to report on a study about how...... networks provide opportunities for teachers from different schools to collaborate on improving the quality of their own science teaching practices. These networks exist at the meso-level of the educational system between the micro-realities of teachers’ individual practice and the macro-level, where...... to develop collaborative activities in primary science teacher communities in schools to improve individual teachers practice and in networks between teachers from different schools in each municipality. Each network was organized and moderated by a municipal science coordinator....

  14. Learning Networks for Professional Development & Lifelong Learning

    NARCIS (Netherlands)

    Sloep, Peter

    2009-01-01

    Sloep, P. B. (2009). Learning Networks for Professional Development & Lifelong Learning. Presentation at a NeLLL seminar with Etienne Wenger held at the Open Universiteit Nederland. September, 10, 2009, Heerlen, The Netherlands.

  15. Development of the Global Measles Laboratory Network.

    Science.gov (United States)

    Featherstone, David; Brown, David; Sanders, Ray

    2003-05-15

    The routine reporting of suspected measles cases and laboratory testing of samples from these cases is the backbone of measles surveillance. The Global Measles Laboratory Network (GMLN) has developed standards for laboratory confirmation of measles and provides training resources for staff of network laboratories, reference materials and expertise for the development and quality control of testing procedures, and accurate information for the Measles Mortality Reduction and Regional Elimination Initiative. The GMLN was developed along the lines of the successful Global Polio Laboratory Network, and much of the polio laboratory infrastructure was utilized for measles. The GMLN has developed as countries focus on measles control activities following successful eradication of polio. Currently more than 100 laboratories are part of the global network and follow standardized testing and reporting procedures. A comprehensive laboratory accreditation process will be introduced in 2002 with six quality assurance and performance indicators.

  16. The European Network for Lifelong Competence Development

    NARCIS (Netherlands)

    Burgos, Daniel

    2006-01-01

    Burgos, D. (2006). The European Network for Lifelong Competence Development. Presentation at the Professional Training Facts 2006 conference. November 15th, Stuttgart, Germany: TENCompetence. Retrieved November 20th, 2006, from http://dspace.learningnetworks.org

  17. Analysis of disturbances in the 15 kV traction power network by means of simulation calculations and tests; Analyse von Stoerungen im 15-kV-Bahnenergienetz durch Simulationsrechnungen und Versuche

    Energy Technology Data Exchange (ETDEWEB)

    Aeberhard, Martin; Basler, Egon [SBB AG, Zollikofen (Switzerland). Infrastruktur Energie

    2013-06-15

    Being one of the most important rail junctions of Switzerland, Olten is powered by a substation the 132 kV feeder of which features a number of structural weaknesses. Simulations were used to analyse the effects of electrical equipment failures in this substation on train operation, the nearby 15 kV overhead line system and the loads adjacent substations are subjected to. By considering all risks, a critical case of train operation with different load scenarios was investigated. The article includes a comparison between simulated and measured data and presents the conclusions that were drawn from the actions taken in respect of the future system design. (orig.)

  18. 78 FR 17418 - Rural Health Information Technology Network Development Grant

    Science.gov (United States)

    2013-03-21

    ... Information Technology Network Development Grant AGENCY: Health Resources and Services Administration (HRSA...-competitive replacement award under the Rural Health Information Technology Network Development Grant (RHITND... relinquishing its fiduciary responsibilities for the Rural Health Information Technology Network Development...

  19. Hvor fosser kvælstoffet hen?

    DEFF Research Database (Denmark)

    Larsen, Torben

    Der har i Ingeniøren inden i et par måneder kunne læses adskillelige ivrige indlæg om de danske fjordes evne til at fjerne kvælstof. Kvælstof fosser ud af fjordene? lød en af de første overskrifter. Få uger efter blev det stik modsatte synspunkt fremført under overskriften Fjordene holder på kvæl...

  20. Networking in gendered regional development

    OpenAIRE

    Mona Hedfeldt; Gun Hedlund

    2011-01-01

    The present Swedish regionalization process creates a lack of institutionalisation called the "regional mess" (Stegmann McCallion 2008:587). According to a state investigation, Sweden has a "fragmented growth- and development policy as well as a weak and unclear regional organisation of society" (SOU 2007:10:18). Old and new structures are intertwined and the question emerges if this situation may create a space for women regarding regional development (Hedfeldt & Hedlund 2009). A multi-level...

  1. Compact 250-kV injector system for PIGMI

    International Nuclear Information System (INIS)

    Hamm, R.W.; Stevens, R.R. Jr.; Mueller, D.W.; Lederer, H.M.

    1978-01-01

    A 250-kV proton injector to be used in the development of a linac suitable for medical applications has been constructed. This injector utilizes a spherical Pierce geometry to produce a converging beam. A gas insulated accelerating column is cantilevered on a grounded vacuum system, with a separate high voltage equipment dome connected to a 300-kV Cockcroft-Walton power supply. The injector can be operated locally or remotely, with the remote control accomplished by a microprocessor system linked to a central control minicomputer. This injector has been designed as a low-cost compact system. The design details and the data obtained during initial operation are presented

  2. Satellite ATM Networks: Architectures and Guidelines Developed

    Science.gov (United States)

    vonDeak, Thomas C.; Yegendu, Ferit

    1999-01-01

    An important element of satellite-supported asynchronous transfer mode (ATM) networking will involve support for the routing and rerouting of active connections. Work published under the auspices of the Telecommunications Industry Association (http://www.tiaonline.org), describes basic architectures and routing protocol issues for satellite ATM (SATATM) networks. The architectures and issues identified will serve as a basis for further development of technical specifications for these SATATM networks. Three ATM network architectures for bent pipe satellites and three ATM network architectures for satellites with onboard ATM switches were developed. The architectures differ from one another in terms of required level of mobility, supported data rates, supported terrestrial interfaces, and onboard processing and switching requirements. The documentation addresses low-, middle-, and geosynchronous-Earth-orbit satellite configurations. The satellite environment may require real-time routing to support the mobility of end devices and nodes of the ATM network itself. This requires the network to be able to reroute active circuits in real time. In addition to supporting mobility, rerouting can also be used to (1) optimize network routing, (2) respond to changing quality-of-service requirements, and (3) provide a fault tolerance mechanism. Traffic management and control functions are necessary in ATM to ensure that the quality-of-service requirements associated with each connection are not violated and also to provide flow and congestion control functions. Functions related to traffic management were identified and described. Most of these traffic management functions will be supported by on-ground ATM switches, but in a hybrid terrestrial-satellite ATM network, some of the traffic management functions may have to be supported by the onboard satellite ATM switch. Future work is planned to examine the tradeoffs of placing traffic management functions onboard a satellite as

  3. Cross-platform wireless sensor network development

    DEFF Research Database (Denmark)

    Hansen, Morten Tranberg; Kusy, Branislav

    Design and development of wireless sensor network applications adds an additional layer of complexity to traditional computer systems. The developer needs to be an expert in resource constrained embedded devices as well as traditional desktop computers. We propose Tinylnventor, an open...

  4. The development of brain network architecture

    NARCIS (Netherlands)

    Wierenga, Lara M.; van den Heuvel, Martijn P.; van Dijk, Sarai; Rijks, Yvonne; de Reus, Marcel A.; Durston, Sarah

    2016-01-01

    Brain connectivity shows protracted development throughout childhood and adolescence, and, as such, the topology of brain networks changes during this period. The complexity of these changes with development is reflected by regional differences in maturation. This study explored age-related changes

  5. Developing a network: the PMM process.

    Science.gov (United States)

    Kamara, A

    1997-11-01

    Since 1988, the Prevention of Maternal Mortality (PMM) Network has developed, implemented and evaluated projects that focus directly on prevention of maternal deaths. The Network, which consists of 11 multidisciplinary teams in West Africa and one at Columbia University, grew from discussions between the Carnegie Corporation of New York and researchers at Columbia School of Public Health. Its goals are: to strengthen capacities in developing countries; to provide program models for preventing maternal deaths; and to inform policymakers about the importance of maternal mortality. This paper describes the development and functioning of the Network. The initial steps included identifying interested partners in Africa and encouraging them to form multidisciplinary teams. Each African team received two grants: one to perform a needs assessment and then another to develop and implement projects based on the results. The Columbia team provided technical assistance in a variety of ways, including site visits, workshops and correspondence. Teams tested program models and reported findings both to local policymakers and in international fora. Collaboration with government and community leaders helped facilitate progress at all stages. At the PMM Network Results Conference in 1996, the teams decided to continue their work by forming the Regional PMM (RPMM) Network, an entirely African entity.

  6. Technology development in market networks

    International Nuclear Information System (INIS)

    Olerup, B.

    2001-01-01

    Technology procurement is used as an environmental control means in Sweden to promote the manufacturing and sale of energy-efficient technologies. The public authority in charge makes use of the market mechanism in alternating co-operative and competitive elements. The fragmented market, with its standardised products for many small customers, is brought together to specify desired product developments. These demands also include other qualities besides energy efficiency. A contest is announced in which a possible future market is indicated to manufacturers. Efforts are made to enlarge the market to motivate their investment and to keep down the unit cost. Each side in the deal is thus given an incentive to act in the desired direction. (author)

  7. Product Platform Development in Industrial Networks

    DEFF Research Database (Denmark)

    Karlsson, Christer; Skold, Martin

    2011-01-01

    The article examines the strategic issues involved in the deployment of product platform development in an industrial network. The move entails identifying the types and characteristics of generically different product platform strategies and clarifying strategic motives and differences. Number o...... of platforms and product brands serve as the key dimensions when distinguishing the different strategies. Each strategy has its own challenges and raises various issues to deal with.......The article examines the strategic issues involved in the deployment of product platform development in an industrial network. The move entails identifying the types and characteristics of generically different product platform strategies and clarifying strategic motives and differences. Number...

  8. Discrete fracture network code development

    Energy Technology Data Exchange (ETDEWEB)

    Dershowitz, W.; Doe, T.; Shuttle, D.; Eiben, T.; Fox, A.; Emsley, S.; Ahlstrom, E. [Golder Associates Inc., Redmond, Washington (United States)

    1999-02-01

    This report presents the results of fracture flow model development and application performed by Golder Associates Inc. during the fiscal year 1998. The primary objective of the Golder Associates work scope was to provide theoretical and modelling support to the JNC performance assessment effort in fiscal year 2000. In addition, Golder Associates provided technical support to JNC for the Aespoe project. Major efforts for performance assessment support included extensive flow and transport simulations, analysis of pathway simplification, research on excavation damage zone effects, software verification and cross-verification, and analysis of confidence bounds on Monte Carlo simulations. In addition, a Fickian diffusion algorithm was implemented for Laplace Transform Galerkin solute transport. Support for the Aespoe project included predictive modelling of sorbing tracer transport in the TRUE-1 rock block, analysis of 1 km geochemical transport pathways for Task 5', and data analysis and experimental design for the TRUE Block Scale experiment. Technical information about Golder Associates support to JNC is provided in the appendices to this report. (author)

  9. The electrically silent Kv6.4 subunit confers hyperpolarized gating charge movement in Kv2.1/Kv6.4 heterotetrameric channels.

    Directory of Open Access Journals (Sweden)

    Elke Bocksteins

    Full Text Available The voltage-gated K(+ (Kv channel subunit Kv6.4 does not form functional homotetrameric channels but co-assembles with Kv2.1 to form functional Kv2.1/Kv6.4 heterotetrameric channels. Compared to Kv2.1 homotetramers, Kv6.4 exerts a ~40 mV hyperpolarizing shift in the voltage-dependence of Kv2.1/Kv6.4 channel inactivation, without a significant effect on activation gating. However, the underlying mechanism of this Kv6.4-induced modulation of Kv2.1 channel inactivation, and whether the Kv6.4 subunit participates in the voltage-dependent gating of heterotetrameric channels is not well understood. Here we report distinct gating charge movement of Kv2.1/Kv6.4 heterotetrameric channels, compared to Kv2.1 homotetramers, as revealed by gating current recordings from mammalian cells expressing these channels. The gating charge movement of Kv2.1/Kv6.4 heterotetrameric channels displayed an extra component around the physiological K(+ equilibrium potential, characterized by a second sigmoidal relationship of the voltage-dependence of gating charge movement. This distinct gating charge displacement reflects movement of the Kv6.4 voltage-sensing domain and has a voltage-dependency that matches the hyperpolarizing shift in Kv2.1/Kv6.4 channel inactivation. These results provide a mechanistic basis for the modulation of Kv2.1 channel inactivation gating kinetics by silent Kv6.4 subunits.

  10. A compact 100 kV high voltage glycol capacitor.

    Science.gov (United States)

    Wang, Langning; Liu, Jinliang; Feng, Jiahuai

    2015-01-01

    A high voltage capacitor is described in this paper. The capacitor uses glycerol as energy storage medium, has a large capacitance close to 1 nF, can hold off voltages of up to 100 kV for μs charging time. Allowing for low inductance, the capacitor electrode is designed as coaxial structure, which is different from the common structure of the ceramic capacitor. With a steady capacitance at different frequencies and a high hold-off voltage of up to 100 kV, the glycol capacitor design provides a potential substitute for the ceramic capacitors in pulse-forming network modulator to generate high voltage pulses with a width longer than 100 ns.

  11. Co-Operative Learning and Development Networks.

    Science.gov (United States)

    Hodgson, V.; McConnell, D.

    1995-01-01

    Discusses the theory, nature, and benefits of cooperative learning. Considers the Cooperative Learning and Development Network (CLDN) trial in the JITOL (Just in Time Open Learning) project and examines the relationship between theories about cooperative learning and the reality of a group of professionals participating in a virtual cooperative…

  12. Comprehensive information system development and networking in ...

    African Journals Online (AJOL)

    Background/Aim: Hospital Information System(HIS) and Networking development is now the most important technology that must be embraced by all hospitals and clinics these days. Patients sometimes used to face problems in order to have quick and good services in the hospitals, often due to delay in searching for the ...

  13. Learning in Networks for Sustainable Development

    NARCIS (Netherlands)

    Lansu, Angelique; Boon, Jo; Sloep, Peter; Van Dam-Mieras, Rietje

    2010-01-01

    The didactic model of remote internships described in this study provides the flexibility needed to support networked learners, i.e. to facilitate the development and subsequent assessment of their competences. The heterogeneity of the participants (students, employers, tutors) in the learning

  14. Development of steering system in network environment

    International Nuclear Information System (INIS)

    Kanagawa, Fumihiro; Noguchi, So; Yamashita, Hideo

    2002-01-01

    We have been developing the steering system, which can successively observe the-data obtained during the numerical computation and change the parameters in the analysis. Moreover, this system is also extended to link the network. By using this system, a user can easily detect errors immediately and achieve the rapid and accurate analysis with lower computation cost. (Author)

  15. Kv10.1 potassium channel: from the brain to the tumors.

    Science.gov (United States)

    Cázares-Ordoñez, V; Pardo, L A

    2017-10-01

    The KCNH1 gene encodes the Kv10.1 (Eag1) ion channel, a member of the EAG (ether-à-go-go) family of voltage-gated potassium channels. Recent studies have demonstrated that KCHN1 mutations are implicated in Temple-Baraitser and Zimmermann-Laband syndromes and other forms of developmental deficits that all present with mental retardation and epilepsy, suggesting that Kv10.1 might be important for cognitive development in humans. Although the Kv10.1 channel is mainly expressed in the mammalian brain, its ectopic expression occurs in 70% of human cancers. Cancer cells and tumors expressing Kv10.1 acquire selective advantages that favor cancer progression through molecular mechanisms that involve several cellular pathways, indicating that protein-protein interactions may be important for Kv10.1 influence in cell proliferation and tumorigenesis. Several studies on transcriptional and post-transcriptional regulation of Kv10.1 expression have shown interesting mechanistic insights about Kv10.1 role in oncogenesis, increasing the importance of identifying the cellular factors that regulate Kv10.1 expression in tumors.

  16. Development of the brain's functional network architecture.

    Science.gov (United States)

    Vogel, Alecia C; Power, Jonathan D; Petersen, Steven E; Schlaggar, Bradley L

    2010-12-01

    A full understanding of the development of the brain's functional network architecture requires not only an understanding of developmental changes in neural processing in individual brain regions but also an understanding of changes in inter-regional interactions. Resting state functional connectivity MRI (rs-fcMRI) is increasingly being used to study functional interactions between brain regions in both adults and children. We briefly review methods used to study functional interactions and networks with rs-fcMRI and how these methods have been used to define developmental changes in network functional connectivity. The developmental rs-fcMRI studies to date have found two general properties. First, regional interactions change from being predominately anatomically local in children to interactions spanning longer cortical distances in young adults. Second, this developmental change in functional connectivity occurs, in general, via mechanisms of segregation of local regions and integration of distant regions into disparate subnetworks.

  17. Development of Healthy Cities networks in Europe.

    Science.gov (United States)

    Goepel, Eberhard

    2007-01-01

    The Healthy Cities network in Europe was inspired by the Ottawa Charter for Health Promotion when it was launched in 1987. The networking process was initiated by the WHO Regional Office for Europe, but developed its own dynamics in different European countries during a time marked by fundamental political transformations in many of the countries of Eastern Europe. The networks then connected with the 'Local Agenda 21' and the 'Sustainable Cities and Towns Campaign' to create a new and broader programmatic agenda at the local level. In particular, the ''Aalborg plus 10 - commitments"--of local governments in 2004 have the potential to inspire a new phase of participatory and sustainable policies at the level of local communities in Europe. However, the extent to which these initiatives will influence the macro-politics of the European Union towards a proclaimed "Europe of Citizens" remains to be watched carefully during the coming years.

  18. NETWORKING - THE URBAN AND REGIONAL DEVELOPMENT STRATEGY?

    Directory of Open Access Journals (Sweden)

    MARIA NOWICKA-SKOWRON

    2011-01-01

    Full Text Available The concept of innovations embraces everything that is connected with creation and application of new knowledge in order to win competitive advantage. A traditional approach applied by organizational and management sciences are not enough to explain and manage the development of enterprises as well as that of cities, regions and countries. According to a new approach to innovativeness, creation of innovations depends on a complex/system approach. A phenomenon of particular importance is the approach to network pro-innovation structures from the urban and regional point of view. What makes a network work is a mutual relation between actors who have same rights to access and participate in the network. The whole system must be perceived by every actor. Simultaneously, every actor is partially responsible for the whole. The nature of networking can be understood as a differentiated system of relations (particularly personal ones inside the network. Tolerance and trust are other foundations of information flow and information return.

  19. Developing a Virtual Network of Research Observatories

    Science.gov (United States)

    Hooper, R. P.; Kirschtl, D.

    2008-12-01

    The hydrologic community has been discussing the concept of a network of observatories for the advancement of hydrologic science in areas of scaling processes, in testing generality of hypotheses, and in examining non-linear couplings between hydrologic, biotic, and human systems. The Consortium of Universities for the Advancement of Hydrologic Science, Inc. (CUAHSI) is exploring the formation of a virtual network of observatories, formed from existing field studies without regard to funding source. Such a network would encourage sharing of data, metadata, field methods, and data analysis techniques to enable multidisciplinary synthesis, meta-analysis, and scientific collaboration in hydrologic and environmental science and engineering. The virtual network would strive to provide both the data and the environmental context of the data through advanced cyberinfrastructure support. The foundation for this virtual network is Water Data Services that enable the publication of time-series data collected at fixed points using a services-oriented architecture. These publication services, developed in the CUAHSI Hydrologic Information Systems project, permit the discovery of data from both academic and government sources through a single portal. Additional services under consideration are publication of geospatial data sets, immersive environments based upon site digital elevation models, and a common web portal to member sites populated with structured data about the site (such as land use history and geologic setting) to permit understanding the environmental context of the data being shared.

  20. Kv2 Ion Channels Determine the Expression and Localization of the Associated AMIGO-1 Cell Adhesion Molecule in Adult Brain Neurons

    Directory of Open Access Journals (Sweden)

    Hannah I. Bishop

    2018-01-01

    Full Text Available Voltage-gated K+ (Kv channels play important roles in regulating neuronal excitability. Kv channels comprise four principal α subunits, and transmembrane and/or cytoplasmic auxiliary subunits that modify diverse aspects of channel function. AMIGO-1, which mediates homophilic cell adhesion underlying neurite outgrowth and fasciculation during development, has recently been shown to be an auxiliary subunit of adult brain Kv2.1-containing Kv channels. We show that AMIGO-1 is extensively colocalized with both Kv2.1 and its paralog Kv2.2 in brain neurons across diverse mammals, and that in adult brain, there is no apparent population of AMIGO-1 outside of that colocalized with these Kv2 α subunits. AMIGO-1 is coclustered with Kv2 α subunits at specific plasma membrane (PM sites associated with hypolemmal subsurface cisternae at neuronal ER:PM junctions. This distinct PM clustering of AMIGO-1 is not observed in brain neurons of mice lacking Kv2 α subunit expression. Moreover, in heterologous cells, coexpression of either Kv2.1 or Kv2.2 is sufficient to drive clustering of the otherwise uniformly expressed AMIGO-1. Kv2 α subunit coexpression also increases biosynthetic intracellular trafficking and PM expression of AMIGO-1 in heterologous cells, and analyses of Kv2.1 and Kv2.2 knockout mice show selective loss of AMIGO-1 expression and localization in neurons lacking the respective Kv2 α subunit. Together, these data suggest that in mammalian brain neurons, AMIGO-1 is exclusively associated with Kv2 α subunits, and that Kv2 α subunits are obligatory in determining the correct pattern of AMIGO-1 expression, PM trafficking and clustering.

  1. Developing cyber security architecture for military networks using cognitive networking

    OpenAIRE

    Kärkkäinen, Anssi

    2015-01-01

    In recent years, the importance of cyber security has increased. Cyber security has not become a critical issue only for governmental or business actors, but also for armed forces that nowadays rely on national or even global networks in their daily activities. The Network Centric Warfare (NCW) paradigm has increased the significance of networking during last decades as it enables information superiority in which military combat power increased by networking the battlefield actors from perspe...

  2. Operations Plan for Support Network Development

    Energy Technology Data Exchange (ETDEWEB)

    None

    2008-06-30

    This report describes the operational processes and strategies that are building a support network for the National Security Technology Incubator (NSTI) program. The NSTI program currently is under development as part of the National Security Preparedness Project (NSPP), funded by Department of Energy (DOE)/National Nuclear Security Administration (NNSA) Grant No. DE FG52-07NA28084. Although the NSTI program offers a wide array of in-house business services, there are a certain number of services that will be provided by entities outside of Arrowhead Center. This report identifies the steps needed to develop an appropriate support network. The Arrowhead Center is working with external service providers and key stakeholders to establish feasible referral and implementation mechanics offering NSTI program participants the most comprehensive incubation services possible.

  3. Towards the development of European networks

    International Nuclear Information System (INIS)

    Hanreich, G.

    2004-01-01

    The second AFG (French Gas Association) forum, held on June 17, addressed the issue of links between European networks with presentations by Guenther Hainreich, Director of Trans-European Networks for the European Commission Energy and Transport DG, and Loannis Galanis, Assistant Unit Director for the European Commission Energy and Transport DG. The choice for this topic has been influenced by the opening of gas markets in Europe which supposes that two conditions are fulfilled: first, the existence of gas availabilities, and second, the development of transportation, storage and LNG terminal infrastructures. In this context, the national policies are today the regional variations of a European policy at the service of the reinforcement of isolated areas and of the sustain of expanding areas. It is thus necessary to consider the European point-of-view about the existing infrastructures, their development and their financing means

  4. The Dynamic and Changing Development of EERA Networks

    Science.gov (United States)

    Figueiredo, Maria P.; Grosvenor, Ian; Hoveid, Marit Honerod; Macnab, Natasha

    2014-01-01

    In this article the authors use two EERA networks as a case for a discussion on the development of research networks within the European Educational Research Association (EERA). They contend that EERA networks through their way of working create a European research space. As their case shows, the development of networks is diverse. The emergence…

  5. Strategic Networks for Sustainable Tourism Development

    Directory of Open Access Journals (Sweden)

    Ivelyna Krasteva Yoveva

    2014-12-01

    Full Text Available This paper proposes an innovative approach towards introduction of an up-to-date sustainable development philosophy founded on the principles of combination and balance of common and individual interests on multilateral perspective, i.e. individuals vs. organizations, public groups vs. governmental authorities, industry vs. macroeconomic development, nation states vs. international regional development etc. The optimal implementation of such an approach is imminently dependent on an authentic self-awareness of own identity, values, purposes and motivation for positive contribution to the common well-being. The author’s arguments are based on the conviction that when more individuals and organizations harness deeper understanding of the mutual benefits within their operations area and undertake collaborative efforts to solve common problem their steadfast long-term development may be secured even in times of social-economic-political-eco-etc. crises and within a dynamically changing environment.Main purpose of current article is the concentration of the research on looking for and applying the principles of consistency, exchange of good collaborative practices and consequently strategic and operational utilization of the synergy effect, systems thinking and the holistic approach. Collaborative efforts would lead to greater effectiveness and optimization that satisfies individual and common interests in multiple environmental dimensions. The study aims to analyze the potential of a new network paradigm for provision of effectively applied strategies within the contemporary sustainable development context.Some good practices within the area of joint development of sustainable strategic networks in tourism industry in Bulgaria are presented. A case study of a culinary and hospitality cluster recently established in the Dobrudzha region is about to demonstrates the strategic network viability and sustainability in a contemporary agricultural

  6. Strategy development management of Multimodal Transport Network

    Directory of Open Access Journals (Sweden)

    Nesterova Natalia S.

    2016-01-01

    Full Text Available The article gives a brief overview of works on the development of transport infrastructure for multimodal transportation and integration of Russian transport system into the international transport corridors. The technology for control of the strategy, that changes shape and capacity of Multi-modal Transport Network (MTN, is considered as part of the methodology for designing and development of MTN. This technology allows to carry out strategic and operational management of the strategy implementation based on the use of the balanced scorecard.

  7. Decreased expression of Kv7 channels in Hirchsprung's disease.

    Science.gov (United States)

    O'Donnell, Anne-Marie; Coyle, David; Puri, Prem

    2017-07-01

    Voltage-dependent K + channels (Kv channels) participate in electrical rhythmicity and smooth muscle responses and are regulated by excitatory and inhibitory neurotransmitters. Kv channels also participate in the interstitial cell of Cajal (ICC) and smooth muscle cell (SMC) responses to neural inputs. The Kv family consists of 12 subfamilies, Kv1-Kv12, with five members of the Kv7 family identified to date: Kv7.1-Kv7.5. A recent study identified the potassium channel Kv7.5 as having a role in the excitability of ICC-IM in the mouse colon. We therefore designed this study to test the hypothesis that Kv7 channels are present in the normal human colon and are reduced in Hirschprung's disease (HSCR). HSCR tissue specimens were collected at the time of pull-through surgery (n=10), while normal control tissue specimens were obtained at the time of colostomy closure in patients with imperforate anus (n=10). Kv7.3-Kv7.5 immunohistochemistry was performed and visualized using confocal microscopy to assess their distribution. Western blot analysis was undertaken to determine Kv7.3-Kv7.5 protein quantification. Kv7.3 and Kv7.4-immunoreactivity was co-localized with neuron and ICC markers, while Kv7.5 was found to be expressed on both ICCs and SMCs. Western blot analysis revealed similar levels of Kv7.3 and Kv7.5 expression in the normal colon and HSCR colon, while Kv7.4 proteins were found to be markedly decreased in ganglionic specimens and decreased further in aganglionic specimens. A deficiency of Kv7.4 channels in the ganglionic and aganglionic bowel may place a role in colonic dysmotility in HSCR. Copyright © 2017 Elsevier Inc. All rights reserved.

  8. NETWORKING - THE URBAN AND REGIONAL DEVELOPMENT STRATEGY?

    Directory of Open Access Journals (Sweden)

    PIOTR PACHURA

    2008-01-01

    Full Text Available It has become more and more common to claim that the concept of innovations embraces everything that is connected with creation and application of new knowledge in order to win competitive advantage. In this respect innovations concern as well, apart from technology, economy, society and culture. A traditional approach applied by organizational and management sciences is not enough to explain and manage the development of enterprises as well as that of cities, regions and countries. Simultaneously, according to a new approach to innovativeness, creation of innovations depends on a complex/system approach. The word complex is vital since this approach should embrace the complexity of innovative networks as well as complexity of relations of cooperation and the whole network environment together with social context.

  9. Development of IT-based data communication network technology

    International Nuclear Information System (INIS)

    Hong, Seok Boong; Jeong, K. I.; Yoo, Y. R.

    2010-10-01

    - Developing broadband high-reliability real-time communications technology for NPP - Developing reliability and performance validation technology for communications network - Developing security technology for NPP communications network - Developing field communications network for harsh environment of NPP - International standard registration(Oct. 28, 2009, IEC 61500

  10. Innovations and networking fostering tourist destination development in Slovakia

    Directory of Open Access Journals (Sweden)

    Gajdošík Tomáš

    2017-12-01

    Full Text Available The paper focuses on the implementation of innovations and networking in the sector of tourism in two Slovak mountain destinations of international significance. The main objective of the paper is to identify and evaluate how innovations and networking contribute to tourist destination development in Slovakia. The implementation of institutional innovation resulted in the establishment of formal and informal networks. The developed networks consist of representatives of all sectors co-ordinating all relevant stakeholders. Formal and informal networks and the collaboration among stakeholders have launched other types of innovations in the tourism sector. The interactions and intensity of relations among stakeholders are analysed by network analysis. Destinations are compared with the network of the same size and density through quantitative network characteristics. Based on empirical research we investigate the impact of networks and innovations on tourist destination development. Due to the synergy effect of networking and implementation of multiple innovations, tourist destination development is observed.

  11. The development of brain network architecture.

    Science.gov (United States)

    Wierenga, Lara M; van den Heuvel, Martijn P; van Dijk, Sarai; Rijks, Yvonne; de Reus, Marcel A; Durston, Sarah

    2016-02-01

    Brain connectivity shows protracted development throughout childhood and adolescence, and, as such, the topology of brain networks changes during this period. The complexity of these changes with development is reflected by regional differences in maturation. This study explored age-related changes in network topology and regional developmental patterns during childhood and adolescence. We acquired two sets of Diffusion Weighted Imaging-scans and anatomical T1-weighted scans. The first dataset included 85 typically developing individuals (53 males; 32 females), aged between 7 and 23 years and was acquired on a Philips Achieva 1.5 Tesla scanner. A second dataset (N = 38) was acquired on a different (but identical) 1.5 T scanner and was used for independent replication of our results. We reconstructed whole brain networks using tractography. We operationalized fiber tract development as changes in mean diffusivity and radial diffusivity with age. Most fibers showed maturational changes in mean and radial diffusivity values throughout childhood and adolescence, likely reflecting increasing white matter integrity. The largest age-related changes were observed in association fibers within and between the frontal and parietal lobes. Furthermore, there was a simultaneous age-related decrease in average path length (P maturational model where connections between unimodal regions strengthen in childhood, followed by connections from these unimodal regions to association regions, while adolescence is characterized by the strengthening of connections between association regions within the frontal and parietal cortex. Hum Brain Mapp 37:717-729, 2016. © 2015 Wiley Periodicals, Inc. © 2015 Wiley Periodicals, Inc.

  12. The Seismic Analysis of 800kV Gas Insulated Switchgear (GIS) for the Dangjin Thermal Plant

    Energy Technology Data Exchange (ETDEWEB)

    Shin, I.H.; Song, W.P.; Kweon, K.Y. [Hyosung Corporation (Korea)

    1999-05-01

    800kV GIS (Gas Insulated Switchgear) which was first developed in korea at Dec. 1998 and is going to be installed in the dangjin thermal plant. We checked the stability of 800kV GIS under seismic load. pro-ENGINEER and PATRAN were used for modeling exactly 800kV GIS geometry. The 800kV GIS was modeled as shell elements for the enclosures and beam elements for the conductors and the support insulators. (author). 2 refs., 9 figs., 2 tabs.

  13. The short-circuit test results of 6.9 kV/2.3 kV 400 kVA-class YBCO model transformer

    International Nuclear Information System (INIS)

    Tomioka, A.; Otonari, T.; Ogata, T.; Iwakuma, M.; Okamoto, H.; Hayashi, H.; Iijima, Y.; Saito, T.; Gosho, Y.; Tanabe, K.; Izumi, T.; Shiohara, Y.

    2011-01-01

    The 6.9 kV/2.3 kV 400 kVA-class single-phase YBCO model transformer with the YBCO tape with copper tape was manufactured for short-circuit current test. Short-circuit test was performed and the short-circuit current of primary winding was 346 A which was about six times larger than the rated current. The I-V characteristics of the winding did not change before and after the test. The transformer withstood short-circuit current. We are planning to turn the result into a consideration of a 66 kV/6.9 kV-20 MVA-class three-phase superconducting transformer. We are developing an elemental technology for 66 kV/6.9 kV 20 MVA-class power transformer with YBCO conductors. The protection of short-circuit technology is one of the elemental technologies for HTS transformer. Since short-circuit current is much higher than critical current of YBCO tape, there is a possibility that superconducting characteristics may be damaged during short-circuit period. We made a conductor to compose the YBCO tape with copper tape. We manufactured 6.9 kV/2.3 kV 400 kVA-class YBCO model transformer using this conductor and performed short-circuit current test. The short-circuit current of primary winding was 346 A which was about six times larger than the rated current. The I-V characteristics of the winding did not change before and after the test. We may consider this conductor withstands short-circuit current.

  14. Functional analysis of Kv1.2 and paddle chimera Kv channels in planar lipid bilayers

    Science.gov (United States)

    Tao, Xiao; MacKinnon, Roderick

    2010-01-01

    Summary Voltage-dependent K+ channels play key roles in shaping electrical signaling in both excitable as well as non-excitable cells. These channels open and close in response to the voltage changes across the cell membrane. Many studies have been carried out in order to understand the voltage sensing mechanism. Our laboratory recently determined the atomic structures of a mammalian voltage-dependent K+ channel Kv1.2 and a mutant of Kv1.2 named the ‘paddle-chimera’ channel, in which the voltage sensor paddle was transferred from Kv2.1 to Kv1.2. These two structures provide atomic descriptions of voltage-dependent channels with unprecedented clarity. Until now the functional integrity of these two channels biosynthesized in yeast cells have not been assessed. Here we report the electrophysiological and pharmacological properties of Kv1.2 and the paddle chimera channels in planar lipid bilayers. We demonstrate that Pichia yeast produce ‘normally functioning’ mammalian voltage-dependent K+ channels with qualitatively similar features to the Shaker K+ channel in the absence of the N-terminal inactivation gate, and that the paddle chimera mutant channel functions as well as Kv1.2. We find, however, that in several respects the Kv1.2 channel exhibits functional properties that are distinct from Kv1.2 channels reported in the literature. PMID:18638484

  15. Developing A Generic Optical Avionic Network

    DEFF Research Database (Denmark)

    Zhang, Jiang; An, Yi; Berger, Michael Stübert

    2011-01-01

    We propose a generic optical network design for future avionic systems in order to reduce the weight and power consumption of current networks on board. A three-layered network structure over a ring optical network topology is suggested, as it can provide full reconfiguration flexibility...... and support a wide range of avionic applications. Segregation can be made on different hierarchies according to system criticality and security requirements. The structure of each layer is discussed in detail. Two network configurations are presented, focusing on how to support different network services...... by such a network. Finally, three redundancy scenarios are discussed and compared....

  16. Community Health Global Network and Sustainable Development

    Directory of Open Access Journals (Sweden)

    Rebekah Young

    2016-01-01

    Full Text Available With the achievements, failures and passing of the Millennium Development Goals (MDG, the world has turned its eyes to the Sustainable Development Goals (SDG, designed to foster sustainable social, economic and environmental development over the next 15 years.(1 Community-led initiatives are increasingly being recognised as playing a key role in realising sustainable community development and in the aspirations of universal healthcare.(2 In many parts of the world, faith-based organisations are some of the main players in community-led development and health care.(3 Community Health Global Network (CHGN creates links between organisations, with the purpose being to encourage communities to recognise their assets and abilities, identify shared concerns and discover solutions together, in order to define and lead their futures in sustainable ways.(4 CHGN has facilitated the development of collaborative groups of health and development initiatives called ‘Clusters’ in several countries including India, Bangladesh, Kenya, Tanzania, Zambia and Myanmar. In March 2016 these Clusters met together in an International Forum, to share learnings, experiences, challenges, achievements and to encourage one another. Discussions held throughout the forum suggest that the CHGN model is helping to promote effective, sustainable development and health care provision on both a local and a global scale.

  17. Blockade of the voltage-gated potassium channel Kv1.3 inhibits immune responses in vivo.

    Science.gov (United States)

    Koo, G C; Blake, J T; Talento, A; Nguyen, M; Lin, S; Sirotina, A; Shah, K; Mulvany, K; Hora, D; Cunningham, P; Wunderler, D L; McManus, O B; Slaughter, R; Bugianesi, R; Felix, J; Garcia, M; Williamson, J; Kaczorowski, G; Sigal, N H; Springer, M S; Feeney, W

    1997-06-01

    The voltage activated K+ channel (Kv1.3) has recently been identified as the molecule that sets the resting membrane potential of peripheral human T lymphoid cells. In vitro studies indicate that blockage of Kv1.3 inhibits T cell activation, suggesting that Kv1.3 may be a target for immunosuppression. However, despite the in vitro evidence, there has been no in vivo demonstration that blockade of Kv1.3 will attenuate an immune response. The difficulty is due to species differences, as the channel does not set the membrane potential in rodent peripheral T cells. In this study, we show that the channel is present on peripheral T cells of miniswine. Using the peptidyl Kv1.3 inhibitor, margatoxin, we demonstrate that Kv1.3 also regulates the resting membrane potential, and that blockade of Kv1.3 inhibits, in vivo, both a delayed-type hypersensitivity reaction and an Ab response to an allogeneic challenge. In addition, prolonged Kv1.3 blockade causes reduced thymic cellularity and inhibits the thymic development of T cell subsets. These results provide in vivo evidence that Kv1.3 is a novel target for immunomodulation.

  18. Development of a 130-mA, 75-kV high voltage column for high-intensity dc proton injectors

    International Nuclear Information System (INIS)

    Sherman, J.; Arvin, A.; Hansborough, L.; Hodgkins, D.; Meyer, E.; Schneider, J.D.; Stevens, R.R. Jr.; Zaugg, T.

    1997-01-01

    A reliable high-voltage (HV) column has been developed for dc proton injectors with applications to high-intensity cw linacs. The HV column is coupled with a microwave-driven plasma generator to produce a 75-keV, 110-mA dc proton beam. Typical proton fraction from this source is 85--90%, requiring the HV column and accelerating electrodes to operate with a 130-mA hydrogen-ion beam current. A glow-discharge, which was caused by the ion source axial magnetic field, was initially observed in the HV column. This problem was solved by scaling the electron production processes, the magnetic field, and the HV column pressure into a favorable regime. A subsequent 168 hour reliability run on the 75-keV injector showed that the ion source (plasma generator and HV column) has >98% beam availability

  19. Choice of 735 kV transmission economics and system performance

    Energy Technology Data Exchange (ETDEWEB)

    McGillis, D T

    1966-01-01

    The present Hydro Quebec load is 8,000 MW and is expected to be 16,000 MW by the late 1970's and 26,000 MW by the middle of the 1980's. This load is concentrated in the area along the St. Lawrence River between Quebec City and Montreal where most of Quebec's six million people live. Fortunately there is in the Province of Quebec enough hydroelectric potential to meet the increase in load that is expected to develop over the next 15 to 20 years. These new sources are, however, at least 500 miles away from the Montreal-Quebec load area. Though this consideration had some bearing on the planning of the Hydro-Quebec ehv network, the choice of 735 kV transmission for the Manicouagan-Outardes project was based principally on economic studies of alternative transmission facilities for this specific project.

  20. [The story of K.V. Tjellesen].

    Science.gov (United States)

    Clemmensen, Peter

    2005-01-01

    øller-Larsen to undergo a generational change. The company was changed from a general partnership to a limited company (Ltd.) on January 1, 1985. At that time, the company's market share was below 3%. Peter Schøller-Larsen had developed a new concept for the company, which involved offering the pharmacy proprietors the opportunity to become share-holders in the company. Along with the newly appointed sales director, pharmacist Peter Clemmensen, a third of all pharmacies in the country received a visit from the company, and more than half of the proprietors accepted the offer and became shareholders in K.V. Tjellesen A/S. This resulted in a rapid influx of new customers and an increasing turnover. Once again, the company was running short of space, and on July 1, 1991, the company moved to Brandstrupvej 4 in Rødovre. At the same time, the trade with pharmaceutical specialties in Denmark was rearranged resulting in a significant increase in the company's stock of goods. In the same period, the number of pharmaceutical wholesalers was reduced from 5 to 3. At the end of 1993, the company decided to take on SupplierService as well. Again, this resulted in the need for more space, and an extension to the buildings on Brandstrupvej was built in 1994. In 1996, new storage rooms were added at Meterbuen in Skovlunde. In 2001, the business area SupplierService developed the area Storage-Hotel, where paramedical products are stored and distributed to other customers than the pharmaceutical wholesalers. This took place when the storage capacity at Meterbuen was further increased. In 2004, the existing bounds at Meterbuen were yet again passed, and at the end of the year, two new and large storage halls were put to use by Tjellesen. These two halls form the StorageHotel. In 1985, Tjellesen had a turnover of approx. DKK 70 million and employed 20 persons. In 2004, Tjellesen generated a turnover of nearly DKK 3 billion and employed 126 persons. From basement rooms measuring 200 m2 in Vester

  1. THE PROSPECTS OF DEVELOPMENT OF ELECTRIC POWER NETWORK IN GEORGIA

    International Nuclear Information System (INIS)

    Mshvidobadze, T.

    2007-01-01

    The possibility of application of one of the versions of development of the electric power network in Georgia is disscussed. The algorithm of grouping of the versions of power network development, which allows choosing the optimal network configuration under indefinite conditions, is offered. The experiments have demonstrated that the same optimal decision can be found by considerable reduction in the number of versions. (author)

  2. The acrylamide (S)-2 as a positive and negative modulator of Kv7 channels expressed in Xenopus laevis oocytes

    DEFF Research Database (Denmark)

    Blom, Sigrid Marie; Schmitt, Nicole; Jensen, Henrik Sindal

    2009-01-01

    Kv7.2-5, is now in clinical trial phase III for the treatment of partial onset seizures. One of the main obstacles in developing Kv7 channel active drugs has been to identify compounds that can discriminate between the neuronal subtypes, a feature that could help diminish side effects and increase...

  3. harmonic load modeling: a case study of 33 kv abuja steel mill feeder

    African Journals Online (AJOL)

    HOD

    An in-depth study of the harmonic orders inherent in a power system network is required ... This paper studied the harmonic orders of the 33 kV Abuja Steel Feeder .... models for various industrial and household electrical ..... Malaysia, 2013.

  4. Networking capability and new product development

    NARCIS (Netherlands)

    Mu, J.; Di Benedetto, A.C.

    2012-01-01

    Current research on network theory remains largely focused on structures and outcomes without exploring the capability that firms need to build efficient and effective networks to their advantage. In this paper, we take a networking capability view in studying inter-firm relationships. We assume

  5. 600 kV modulator design for the SLAC Next Linear Collider Test Accelerator

    International Nuclear Information System (INIS)

    Harris, K.; de Lamare, J.; Nesterov, V.; Cassel, R.

    1992-07-01

    Preliminary design for the SLAC Next Linear Collider Test Accelerator (NLCTA) requires a pulse power source to produce a 600 kV, 600 A, 1.4 μs, 0.1% flat top pulse with rise and fall times of approximately 100 ns to power an X-Band klystron with a microperveance of 1.25 at ∼ 100 MW peak RF power. The design goals for the modulator, including those previously listed, are peak modulator pulse power of 340 MW operating at 120 Hz. A three-stage darlington pulse-forming network, which produces a >100 kV, 1.4 μs pulse, is coupled to the klystron load through a 6:1 pulse transformer. Careful consideration of the transformer leakage inductance, klystron capacitance, system layout, and component choice is necessary to produce the very fast rise and fall times at 600 kV operating continuously at 120 Hz

  6. Independent and cooperative motions of the Kv1.2 channel: voltage sensing and gating.

    Science.gov (United States)

    Yeheskel, Adva; Haliloglu, Turkan; Ben-Tal, Nir

    2010-05-19

    Voltage-gated potassium (Kv) channels, such as Kv1.2, are involved in the generation and propagation of action potentials. The Kv channel is a homotetramer, and each monomer is composed of a voltage-sensing domain (VSD) and a pore domain (PD). We analyzed the fluctuations of a model structure of Kv1.2 using elastic network models. The analysis suggested a network of coupled fluctuations of eight rigid structural units and seven hinges that may control the transition between the active and inactive states of the channel. For the most part, the network is composed of amino acids that are known to affect channel activity. The results suggested allosteric interactions and cooperativity between the subunits in the coupling between the motion of the VSD and the selectivity filter of the PD, in accordance with recent empirical data. There are no direct contacts between the VSDs of the four subunits, and the contacts between these and the PDs are loose, suggesting that the VSDs are capable of functioning independently. Indeed, they manifest many inherent fluctuations that are decoupled from the rest of the structure. In general, the analysis suggests that the two domains contribute to the channel function both individually and cooperatively. Copyright 2010 Biophysical Society. Published by Elsevier Inc. All rights reserved.

  7. Advances in Artificial Neural Networks - Methodological Development and Application

    Science.gov (United States)

    Artificial neural networks as a major soft-computing technology have been extensively studied and applied during the last three decades. Research on backpropagation training algorithms for multilayer perceptron networks has spurred development of other neural network training algorithms for other ne...

  8. Social networks for innovation and new product development

    NARCIS (Netherlands)

    Leenders, R.T.A.J.; Dolfsma, W.

    2016-01-01

    In this article we first provide a brief introduction into social network analysis, focusing on the measures and approaches that are used in the empirical contributions in this special issue. Second, we discuss the role of social networks in new product development. Social networks are inherently

  9. Major trends in the development of electrical power systems

    Energy Technology Data Exchange (ETDEWEB)

    Syromyatnikov, I A

    1965-01-01

    The comparison is made between the USA and the USSR electrical systems and their growth. The author states that USSR is about 35 years behind in the construction of power transmission lines of 22 kV and above. Various graphs of economic developments are presented. It is stated that the work in the near future should be concentrated on 750 kV network and on combining the USSR electric power distribution into a single power system.

  10. Advances in Artificial Neural Networks – Methodological Development and Application

    Directory of Open Access Journals (Sweden)

    Yanbo Huang

    2009-08-01

    Full Text Available Artificial neural networks as a major soft-computing technology have been extensively studied and applied during the last three decades. Research on backpropagation training algorithms for multilayer perceptron networks has spurred development of other neural network training algorithms for other networks such as radial basis function, recurrent network, feedback network, and unsupervised Kohonen self-organizing network. These networks, especially the multilayer perceptron network with a backpropagation training algorithm, have gained recognition in research and applications in various scientific and engineering areas. In order to accelerate the training process and overcome data over-fitting, research has been conducted to improve the backpropagation algorithm. Further, artificial neural networks have been integrated with other advanced methods such as fuzzy logic and wavelet analysis, to enhance the ability of data interpretation and modeling and to avoid subjectivity in the operation of the training algorithm. In recent years, support vector machines have emerged as a set of high-performance supervised generalized linear classifiers in parallel with artificial neural networks. A review on development history of artificial neural networks is presented and the standard architectures and algorithms of artificial neural networks are described. Furthermore, advanced artificial neural networks will be introduced with support vector machines, and limitations of ANNs will be identified. The future of artificial neural network development in tandem with support vector machines will be discussed in conjunction with further applications to food science and engineering, soil and water relationship for crop management, and decision support for precision agriculture. Along with the network structures and training algorithms, the applications of artificial neural networks will be reviewed as well, especially in the fields of agricultural and biological

  11. Model for the ready definition and approximate comparison of alternative high voltage transmission systems. Phases II and III. Application to electric systems within the contiguous United States. [800 and 1200 kV; 400, 600, and 800 kV dc

    Energy Technology Data Exchange (ETDEWEB)

    1979-08-01

    Research on power delivery alternatives is reported. The first phase of this work was to develop a model of overhead transmission systems in the range of 362 to 1200 kV ac, and +-400 to +-800 kV dc. Such systems included transmission from generation to load and inter-connection of two large integrated systems, with and without the existence of an underlying lower voltage network in either case. This phase has been completed. The second and third phases involved application of the model to electric systems within selected regions of the US, and the entire US, respectively, dealing with real situations and including projected expansion to year 1987. The potential benefits and costs of using higher than existing transmission voltages were to be evaluated on this basis. Additionally, the most advantageous new voltage was to be determined taking into account direct and indirect benefits and costs. The results of the second and third phases are presented.

  12. Functional properties of human neuronal Kv11 channels

    DEFF Research Database (Denmark)

    Einarsen, Karoline; Calloe, Kirstine; Grunnet, Morten

    2009-01-01

    Kv11 potassium channels are important for regulation of the membrane potential. Kv11.2 and Kv11.3 are primarily found in the nervous system, where they most likely are involved in the regulation of neuronal excitability. Two isoforms of human Kv11.2 have been published so far. Here, we present...... current characteristics of the isoforms presented in this work may contribute to the regulation of neuronal excitability....

  13. Professional development and human resources management in networks

    Directory of Open Access Journals (Sweden)

    Evgeniy Rudnev

    2016-05-01

    Full Text Available Social networks occupy more places in development of people and organizations. Confidence in institutions and social networking are different and based on referentiality in Internet. For communication in network persons choose a different strategies and behavior in LinkedIn, resources of whom may be in different degree are interesting in Human Resources Management for organizations. Members of different social groups and cultures demonstrate some differences in interaction with Russian identity native. There are gender differences behavior in networks. Participating in groups need ethical behavior and norms in social networking for professional development and communication in future.

  14. The network evolves | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2011-07-08

    Jul 8, 2011 ... For the 19 young scholars brought together by the Poverty Research Network, the rewards have been substantial. Lu Ming, who describes his experience with the group as “just fantastic,” likens the network to a bridge – connecting China to Canada, and linking researchers to each other and to scholars ...

  15. Networks: Innovation, Growth and Sustainable Development

    Directory of Open Access Journals (Sweden)

    Peter Johnston

    2013-05-01

    Full Text Available The emergence of the Internet as a measureable manifestation of our social and economic relationships changed the domination of networks in our lives. From about 2000, the internet has allowed us to study and understand the type of networks in which we live, and to model their behaviour. The Internet has fundamentally changed the distribution of wealth. The rich became richer simply because of the larger scale of the trading network and stretched national wealth distributions. Network effects are therefore likely to be responsible for much of the perceived increases in inequalities in the last 20-30 years, and policies to tackle poverty must therefore address the extent to which the poor can engage with society's networks of wealth creation. The greatest challenge to continued growth and prosperity, and therefore to peace and justice, is climate change. The potential cost of inaction on climate change could be as high. Our self-organising social networks have structured our societies and economies, and are now reflected in our technology networks. We can now replicate their evolution in computer simulations and can therefore better assess how to deal with the greatest challenges facing us in the next few decades.

  16. Pharmacological Targeting Of Neuronal Kv7.2/3 Channels: A Focus On Chemotypes And Receptor Sites.

    Science.gov (United States)

    Miceli, Francesco; Soldovieri, Maria Virginia; Ambrosino, Paolo; Manocchio, Laura; Medoro, Alessandro; Mosca, Ilaria; Taglialatela, Maurizio

    2017-10-12

    The Kv7 (KCNQ) subfamily of voltage-gated potassium channels consists of 5 members (Kv7.1-5) each showing a characteristic tissue distribution and physiological roles. Given their functional heterogeneity, Kv7 channels represent important pharmacological targets for development of new drugs for neuronal, cardiac and metabolic diseases. In the present manuscript, we focus on describing the pharmacological relevance and the potential therapeutic applications of drugs acting on neuronally-expressed Kv7.2/3 channels, placing particular emphasis on the different modulator chemotypes, and highlighting their pharmacodynamic and, whenever possible, pharmacokinetic peculiarities. The present work is based on an in-depth search of the currently available scientific literature, and on our own experience and knowledge in the field of neuronal Kv7 channel pharmacology. Space limitations impeded to describe the full pharmacological potential of Kv7 channels; thus, we have chosen to focus on neuronal channels composed of Kv7.2 and Kv7.3 subunits, and to mainly concentrate on their involvement in epilepsy. An astonishing heterogeneity in the molecular scaffolds exploitable to develop Kv7.2/3 modulators is evident, with important structural/functional peculiarities of distinct compound classes. In the present work we have attempted to show the current status and growing potential of the Kv7 pharmacology field. We anticipate a bright future for the field, and we express our hopes that the efforts herein reviewed will result in an improved treatment of hyperexcitability (or any other) diseases. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  17. miR-1 is increased in pulmonary hypertension and downregulates Kv1.5 channels in rat pulmonary arteries.

    Science.gov (United States)

    Mondejar-Parreño, Gema; Callejo, María; Barreira, Bianca; Morales-Cano, Daniel; Esquivel-Ruiz, Sergio; Moreno, Laura; Cogolludo, Angel; Perez-Vizcaino, Francisco

    2018-05-02

    ■The expression of miR-1 is increased in lungs from the Hyp/Su5416 PAH rat model. ■PASMC from this animal model are more depolarised and show decreased expression and activity of Kv1.5. ■miR-1 directly targets Kv1.5 channels, reduces Kv1.5 activity and induces membrane depolarization. ■Antagomir-1 prevents Kv1.5 channel downregulation and the depolarization induced by hypoxia/Su5416 exposition. Impairment of voltage-dependent potassium channel (Kv) plays a central role in the development of cardiovascular diseases, including pulmonary arterial hypertension (PAH). MicroRNAs (miRNAs) are non-coding RNAs that regulate gene expression by binding to the 3'-UTR region of specific mRNAs. The aim of this study was to analyze the effects of miR-1 on Kv channel function in pulmonary arteries (PA). Kv channel activity was studied in PA from healthy animals transfected with miR-1 or scrambled-miR. Kv currents were studied using the whole-cell configuration of patch-clamp technique. The characterization of the Kv1.5 currents was performed with the selective inhibitor DPO-1. miR-1 expression was increased and Kv1.5 channels were decreased in lungs from a rat model of PAH induced by hypoxia and Su5416. miR-1 transfection increased cell capacitance, reduced Kv1.5 currents and induced membrane depolarization in isolated pulmonary artery smooth muscle cells (PASMCs). Luciferase reporter assay indicated that KCNA5, which encodes Kv1.5 channels, is a direct target gene of miR-1. Incubation of PA with Su5416 and hypoxia (3% O 2 ) increased miR-1 and induced a decline in Kv1.5 currents, which was prevented by antagomiR-1. In conclusion, these data indicate that miR-1 induces PASMC hypertrophy and reduces the activity and expression of Kv channels, suggesting a pathophysiological role in PAH. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  18. The development and work procedures to super speed network for the growing demands for the network

    International Nuclear Information System (INIS)

    Nosaki, Nobuhisa; Aoki, Kazuhisa

    2001-01-01

    Following the recently growing demands for the network, the modification of Local Area Network (LAN) and Wide Area Network (WAN) to super speed network have been reviewed in the Japan Nuclear Cycle Development Institute (JNC). Though the modification of the LAN to super speed network is being developed this year in Heisei 13 fiscal year, it of the WAN was developed in Heisei 12 fiscal year. In spite of various issues, technical reviews and etc., there are a lot of benefits and merit for the super speed network of the WAN and though the modification of it and reduction of the running cost are contradictory to each other, both of those have been achieved in the JNC. This paper introduces the development and work procedures for the WAN. (author)

  19. Southern African Development Research Network | IDRC ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    ... to craft policies for fruitful integration into the global economy and inclusive growth. ... The grant will support a broad-based research network, the Southern Africa ... researchers based in regional institutions; transforming selected institutions ...

  20. Networks (2005) | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    2016-04-25

    Apr 25, 2016 ... These may include what are called teams, alliances, partnerships, exchanges, joint ... IDRC has always recognized the importance of networks in supporting ... A comprehensive strategic evaluation, launched in 2004, began ...

  1. Time Development in the Early History of Social Networks

    DEFF Research Database (Denmark)

    Bruun, Jesper; Bearden, Ian

    2014-01-01

    Studies of the time development of empirical networks usually investigate late stages where lasting connections have already stabilized. Empirical data on early network history are rare but needed for a better understanding of how social network topology develops in real life. Studying students who...... are beginning their studies at a university with no or few prior connections to each other offers a unique opportunity to investigate the formation and early development of link patterns and community structure in social networks. During a nine week introductory physics course, first year physics students were...... asked to identify those with whom they communicated about problem solving in physics during the preceding week. We use these students' self reports to produce time dependent student interaction networks. We investigate these networks to elucidate possible effects of different student attributes in early...

  2. Federal Plan for Advanced Networking Research and Development

    Data.gov (United States)

    Networking and Information Technology Research and Development, Executive Office of the President — In the four decades since Federal research first enabled computers to send and receive data over networks, U.S. government research and development R and D in...

  3. Agro-food chains and networks for development

    NARCIS (Netherlands)

    Ruben, R.; Slingerland, M.A.; Nijhoff, G.H.

    2006-01-01

    Agro-food chains and networks play an increasingly important role in providing access to markets for producers from developing countries. In developing countries companies become integrated into geographically dispersed supply networks that link producers, traders and processors from the South with

  4. Core Support to Global Development Network (GND) - Phase II ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    The Global Development Network (GDN) was launched by the World Bank in 1999 on the premise that good policy research, properly applied, can accelerate development and improve people's lives. Working mainly through regional networks, GDN supports economic and, increasingly, social science research in and on ...

  5. Networks for Life; scenario development of an ecological network in Cheshire County

    NARCIS (Netherlands)

    Rooij, van S.A.M.; Steingröver, E.G.; Opdam, P.F.M.

    2003-01-01

    In this report, a vision for ecological networks in Cheshire County is developed and presented. This vision is developed in close interaction with the County Council. The vision contains a proposal for sound ecological networks of meres and mosses, heathland, rivers, woodland and grassland. A

  6. Developing equivalent circuits for radial distribution networks

    Energy Technology Data Exchange (ETDEWEB)

    Prada, Ricardo; Coelho, Agnelo; Rodrigues, Anselmo [Catholic University of Rio de Janeiro (PUC-Rio), RJ (Brazil). Dept. of Electrical Engineering], Emails: prada@ele.puc-rio.br, agnelo@ele.puc-rio.br, nebulok_99@yahoo.com; Silva, Maria da Guia da [Federal University of Maranhao, Sao Luiz, MA (Brazil). Dept. of Electrical Engineering

    2009-07-01

    This paper presents a method for evaluating External Equivalent in Electric Distribution Networks (EDN).The proposed method has as its main objectives the reduction of the computational costs in distribution network reconfiguration, investigation of the optimal allocation of banks of capacitors, investigation of the allocation of distributed generation, etc. In these sorts of problems a large number of alternative projects must be assessed in order to identify the optimal solution. The optimal solution comes up with the voltage level in the load points within specified limits. Consequently, the EDN must retain the external network load points but without major increasing in the dimension of the equivalent circuit. The proposed method has been tested and validated in a substation of the Electricity Utility of Maranhao - CEMAR, in Brazil. (author)

  7. Retigabine, a Kv7.2/Kv7.3-Channel Opener, Attenuates Drug-Induced Seizures in Knock-In Mice Harboring Kcnq2 Mutations.

    Science.gov (United States)

    Ihara, Yukiko; Tomonoh, Yuko; Deshimaru, Masanobu; Zhang, Bo; Uchida, Taku; Ishii, Atsushi; Hirose, Shinichi

    2016-01-01

    The hetero-tetrameric voltage-gated potassium channel Kv7.2/Kv7.3, which is encoded by KCNQ2 and KCNQ3, plays an important role in limiting network excitability in the neonatal brain. Kv7.2/Kv7.3 dysfunction resulting from KCNQ2 mutations predominantly causes self-limited or benign epilepsy in neonates, but also causes early onset epileptic encephalopathy. Retigabine (RTG), a Kv7.2/ Kv7.3-channel opener, seems to be a rational antiepileptic drug for epilepsies caused by KCNQ2 mutations. We therefore evaluated the effects of RTG on seizures in two strains of knock-in mice harboring different Kcnq2 mutations, in comparison to the effects of phenobarbital (PB), which is the first-line antiepileptic drug for seizures in neonates. The subjects were heterozygous knock-in mice (Kcnq2Y284C/+ and Kcnq2A306T/+) bearing the Y284C or A306T Kcnq2 mutation, respectively, and their wild-type (WT) littermates, at 63-100 days of age. Seizures induced by intraperitoneal injection of kainic acid (KA, 12mg/kg) were recorded using a video-electroencephalography (EEG) monitoring system. Effects of RTG on KA-induced seizures of both strains of knock-in mice were assessed using seizure scores from a modified Racine's scale and compared with those of PB. The number and total duration of spike bursts on EEG and behaviors monitored by video recording were also used to evaluate the effects of RTG and PB. Both Kcnq2Y284C/+ and Kcnq2A306T/+ mice showed significantly more KA-induced seizures than WT mice. RTG significantly attenuated KA-induced seizure activities in both Kcnq2Y284C/+ and Kcnq2A306T/+ mice, and more markedly than PB. This is the first reported evidence of RTG ameliorating KA-induced seizures in knock-in mice bearing mutations of Kcnq2, with more marked effects than those observed with PB. RTG or other Kv7.2-channel openers may be considered as first-line antiepileptic treatments for epilepsies resulting from KCNQ2 mutations.

  8. Progress made by the South African light metals development network

    CSIR Research Space (South Africa)

    Damm, O

    2009-01-01

    Full Text Available Through focused investment by the CSIR, the South African Innovation Fund, the Automotive Industry Development Centre and the Department of Science and Technology over the past eight years, the national Light Metals Development Network has been...

  9. Developing Principal Instructional Leadership through Collaborative Networking

    Science.gov (United States)

    Cone, Mariah Bahar

    2010-01-01

    This study examines what occurs when principals of urban schools meet together to learn and improve their instructional leadership in collaborative principal networks designed to support, sustain, and provide ongoing principal capacity building. Principal leadership is considered second only to teaching in its ability to improve schools, yet few…

  10. Exploring Social Networking: Developing Critical Literacies

    Science.gov (United States)

    Watson, Pauline

    2012-01-01

    While schools have been using computers within their classrooms for years now, there has been a purposeful ignoring of the growing power of social networks such as Facebook and Twitter. Many schools ban students from accessing and using sites such as Facebook at school and many English and literacy teachers ignore or deny their value as a teaching…

  11. Developing security tools of WSN and WBAN networks applications

    CERN Document Server

    A M El-Bendary, Mohsen

    2015-01-01

    This book focuses on two of the most rapidly developing areas in wireless technology (WT) applications, namely, wireless sensors networks (WSNs) and wireless body area networks (WBANs). These networks can be considered smart applications of the recent WT revolutions. The book presents various security tools and scenarios for the proposed enhanced-security of WSNs, which are supplemented with numerous computer simulations. In the computer simulation section, WSN modeling is addressed using MATLAB programming language.

  12. The subfamily-specific interaction between Kv2.1 and Kv6.4 subunits is determined by interactions between the N- and C-termini.

    Directory of Open Access Journals (Sweden)

    Elke Bocksteins

    Full Text Available The "silent" voltage-gated potassium (KvS channel subunit Kv6.4 does not form electrically functional homotetramers at the plasma membrane but assembles with Kv2.1 subunits, generating functional Kv2.1/Kv6.4 heterotetramers. The N-terminal T1 domain determines the subfamily-specific assembly of Kv1-4 subunits by preventing interactions between subunits that belong to different subfamilies. For Kv6.4, yeast-two-hybrid experiments showed an interaction of the Kv6.4 N-terminus with the Kv2.1 N-terminus, but unexpectedly also with the Kv3.1 N-terminus. We confirmed this interaction by Fluorescence Resonance Energy Transfer (FRET and co-immunoprecipitation (co-IP using N-terminal Kv3.1 and Kv6.4 fragments. However, full-length Kv3.1 and Kv6.4 subunits do not form heterotetramers at the plasma membrane. Therefore, additional interactions between the Kv6.4 and Kv2.1 subunits should be important in the Kv2.1/Kv6.4 subfamily-specificity. Using FRET and co-IP approaches with N- and C-terminal fragments we observed that the Kv6.4 C-terminus physically interacts with the Kv2.1 N-terminus but not with the Kv3.1 N-terminus. The N-terminal amino acid sequence CDD which is conserved between Kv2 and KvS subunits appeared to be a key determinant since charge reversals with arginine substitutions abolished the interaction between the N-terminus of Kv2.1 and the C-terminus of both Kv2.1 and Kv6.4. In addition, the Kv6.4(CKv3.1 chimera in which the C-terminus of Kv6.4 was replaced by the corresponding domain of Kv3.1, disrupted the assembly with Kv2.1. These results indicate that the subfamily-specific Kv2.1/Kv6.4 heterotetramerization is determined by interactions between Kv2.1 and Kv6.4 that involve both the N- and C-termini in which the conserved N-terminal CDD sequence plays a key role.

  13. Effects of haloperidol on Kv4.3 potassium channels.

    Science.gov (United States)

    Lee, Hong Joon; Sung, Ki-Wug; Hahn, Sang June

    2014-10-05

    Haloperidol is commonly used in clinical practice to treat acute and chronic psychosis, but it also has been associated with adverse cardiovascular events. We investigated the effects of haloperidol on Kv4.3 currents stably expressed in CHO cells using a whole-cell patch-clamp technique. Haloperidol did not significantly inhibit the peak amplitude of Kv4.3, but accelerated the decay rate of inactivation of Kv4.3 in a concentration-dependent manner. Thus, the effects of haloperidol on Kv4.3 were estimated from the integral of the Kv4.3 currents during the depolarization pulse. The Kv4.3 was decreased by haloperidol in a concentration-dependent manner with an IC50 value of 3.6 μM. Haloperidol accelerated the decay rate of Kv4.3 inactivation and activation kinetics in a concentration-dependent manner, thereby decreasing the time-to-peak. Haloperidol shifted the voltage dependence of the steady-state activation and inactivation of Kv4.3 in a hyperpolarizing direction. Haloperidol also caused an acceleration of the closed-state inactivation of Kv4.3. Haloperidol produced a use-dependent block of Kv4.3, which was accompanied by a slowing of recovery from the inactivation of Kv4.3. These results suggest that haloperidol blocks Kv4.3 by both interacting with the open state of Kv4.3 channels during depolarization and accelerating the closed-state inactivation at subthreshold membrane potentials. Copyright © 2014 Elsevier B.V. All rights reserved.

  14. Conceptual Developments & Capacity Building in Environmental Networks

    DEFF Research Database (Denmark)

    Lehmann, Martin

    2008-01-01

    Moving from largely command and control measures in the 70s and 80s, through cleaner production and self-regulatory initiatives in the 90s, the emphasis in the new millennium is more on using networks and partnerships as levers for promoting a greening of industry. Predominantly since the 1992 Rio...... corporate stakeholders, civil society and government on the responsible nature of their business practices. So-called ‘Green Networks’, ‘Cleaner Production Centres’, ‘Waste Minimisation Clubs’ are among the highlighted alternatives to governmental regulation. While being promoted as an option...... for governments in the South to make up for lack of sufficient environmental legislation and enforcement, the majority of these examples, however, stem from countries in the North. In terms of public–private partnerships, one of the foremost Danish initiatives is the Green Network in the former county of Vejle...

  15. A versatile framework for cooperative hub network development

    NARCIS (Netherlands)

    Cruijssen, F.C.A.M.; Borm, P.; Dullaert, W.; Hamers, H.

    2010-01-01

    This paper introduces a framework for cooperative hub network development. Building a joint physical hub for the transshipment of goods is expensive and, therefore, involves considerable risks for cooperating companies. In a practical setting, it is unlikely that an entire network will be built at

  16. A versatile framework for cooperative hub network development

    NARCIS (Netherlands)

    Cruijssen, Frans; Borm, Peter; Dullaert, Wout; Hamers, Herbert

    This paper introduces a framework for cooperative hub network development. Building a joint physical hub for the transshipment of goods is expensive and, therefore, involves considerable risks for cooperating companies. In a practical setting, it is unlikely that an entire network will be built at

  17. Social networks and human development / Redes sociales y desarrollo humano

    Directory of Open Access Journals (Sweden)

    Sara Gallego Trijueque

    2011-10-01

    Full Text Available The aim of this work is a brief introduction to the concept of social networks and their importance in society. Social networks have been responsible over the centuries to preserve community values, in addition to being facilitators of social interaction in human development processes, through communication and relationships between individuals.

  18. Leveraging social networks for agricultural development in Africa

    NARCIS (Netherlands)

    Ross, Martha

    2017-01-01

    This thesis contributes to a growing literature that explores relationships between social networks and innovation diffusion within a developing country context. Given this context, the networks of interest within this thesis are the offline interpersonal relationships between community members.

  19. Development of a space-systems network testbed

    Science.gov (United States)

    Lala, Jaynarayan; Alger, Linda; Adams, Stuart; Burkhardt, Laura; Nagle, Gail; Murray, Nicholas

    1988-01-01

    This paper describes a communications network testbed which has been designed to allow the development of architectures and algorithms that meet the functional requirements of future NASA communication systems. The central hardware components of the Network Testbed are programmable circuit switching communication nodes which can be adapted by software or firmware changes to customize the testbed to particular architectures and algorithms. Fault detection, isolation, and reconfiguration has been implemented in the Network with a hybrid approach which utilizes features of both centralized and distributed techniques to provide efficient handling of faults within the Network.

  20. Influences of VSAT network on the economical and industrial development

    Science.gov (United States)

    Lancrenon, B.; Lorent, P.

    1990-10-01

    The adaptable, rapidly assembled and operational VSAT (very small aperature terminal) satellite network is a tool which rapidly provides essential digital infrastructure for business communication networks in order to support and stimulate the development of modern industry. A market analysis is given for VSATs, discussing such topics as applications of the product, retail and distribution, banking finance, and manufacturing industry. The centralized booking of the tourism transport sector is also investigated. The network including the earth stations, the satellite, the systems aspects, and the network management is described in detail and diagrams are provided. Some estimates of space channel cost per year are given.

  1. Networking for Learning The role of Networking in a Lifelong Learner's Professional Development

    OpenAIRE

    Rajagopal, Kamakshi

    2016-01-01

    This dissertation discusses the role the social activity of networking plays in lifelong learners’ professional and personal continuous development. The main hypothesis of this thesis is that networking is a learning strategy for lifelong learners, in which conversations are key activities through which they reassess their held thoughts and make sense of their experiences together with others.

  2. Networking for Learning The role of Networking in a Lifelong Learner's Professional Development

    NARCIS (Netherlands)

    Rajagopal, Kamakshi

    2016-01-01

    This dissertation discusses the role the social activity of networking plays in lifelong learners’ professional and personal continuous development. The main hypothesis of this thesis is that networking is a learning strategy for lifelong learners, in which conversations are key activities through

  3. Influences of brain development and ageing on cortical interactive networks.

    Science.gov (United States)

    Zhu, Chengyu; Guo, Xiaoli; Jin, Zheng; Sun, Junfeng; Qiu, Yihong; Zhu, Yisheng; Tong, Shanbao

    2011-02-01

    To study the effect of brain development and ageing on the pattern of cortical interactive networks. By causality analysis of multichannel electroencephalograph (EEG) with partial directed coherence (PDC), we investigated the different neural networks involved in the whole cortex as well as the anterior and posterior areas in three age groups, i.e., children (0-10 years), mid-aged adults (26-38 years) and the elderly (56-80 years). By comparing the cortical interactive networks in different age groups, the following findings were concluded: (1) the cortical interactive network in the right hemisphere develops earlier than its left counterpart in the development stage; (2) the cortical interactive network of anterior cortex, especially at C3 and F3, is demonstrated to undergo far more extensive changes, compared with the posterior area during brain development and ageing; (3) the asymmetry of the cortical interactive networks declines during ageing with more loss of connectivity in the left frontal and central areas. The age-related variation of cortical interactive networks from resting EEG provides new insights into brain development and ageing. Our findings demonstrated that the PDC analysis of EEG is a powerful approach for characterizing the cortical functional connectivity during brain development and ageing. Copyright © 2010 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

  4. A polyether biotoxin binding site on the lipid-exposed face of the pore domain of Kv channels revealed by the marine toxin gambierol

    Science.gov (United States)

    Kopljar, Ivan; Labro, Alain J.; Cuypers, Eva; Johnson, Henry W. B.; Rainier, Jon D.; Tytgat, Jan; Snyders, Dirk J.

    2009-01-01

    Gambierol is a marine polycyclic ether toxin belonging to the group of ciguatera toxins. It does not activate voltage-gated sodium channels (VGSCs) but inhibits Kv1 potassium channels by an unknown mechanism. While testing whether Kv2, Kv3, and Kv4 channels also serve as targets, we found that Kv3.1 was inhibited with an IC50 of 1.2 ± 0.2 nM, whereas Kv2 and Kv4 channels were insensitive to 1 μM gambierol. Onset of block was similar from either side of the membrane, and gambierol did not compete with internal cavity blockers. The inhibition did not require channel opening and could not be reversed by strong depolarization. Using chimeric Kv3.1–Kv2.1 constructs, the toxin sensitivity was traced to S6, in which T427 was identified as a key determinant. In Kv3.1 homology models, T427 and other molecular determinants (L348, F351) reside in a space between S5 and S6 outside the permeation pathway. In conclusion, we propose that gambierol acts as a gating modifier that binds to the lipid-exposed surface of the pore domain, thereby stabilizing the closed state. This site may be the topological equivalent of the neurotoxin site 5 of VGSCs. Further elucidation of this previously undescribed binding site may explain why most ciguatoxins activate VGSCs, whereas others inhibit voltage-dependent potassium (Kv) channels. This previously undescribed Kv neurotoxin site may have wide implications not only for our understanding of channel function at the molecular level but for future development of drugs to alleviate ciguatera poisoning or to modulate electrical excitability in general. PMID:19482941

  5. Kv7 channels can function without constitutive calmodulin tethering.

    Directory of Open Access Journals (Sweden)

    Juan Camilo Gómez-Posada

    Full Text Available M-channels are voltage-gated potassium channels composed of Kv7.2-7.5 subunits that serve as important regulators of neuronal excitability. Calmodulin binding is required for Kv7 channel function and mutations in Kv7.2 that disrupt calmodulin binding cause Benign Familial Neonatal Convulsions (BFNC, a dominantly inherited human epilepsy. On the basis that Kv7.2 mutants deficient in calmodulin binding are not functional, calmodulin has been defined as an auxiliary subunit of Kv7 channels. However, we have identified a presumably phosphomimetic mutation S511D that permits calmodulin-independent function. Thus, our data reveal that constitutive tethering of calmodulin is not required for Kv7 channel function.

  6. Regulation System for the 18 kV/90 Mvar Compensators

    CERN Document Server

    Burdet, G

    2001-01-01

    Two 18 kV/90 Mvar static compensators are involved to stabilise the voltage, filter the harmonics and compensate the reactive power generated by the power converters used to supply the SPS accelerator magnets. The in-house hardware and software used by the regulation systems, difficult to maintain and upgrade, shall be renovated. Industrial solution based on PLC will be implemented. This paper describes the future system and its integration to the Electrical Network Supervisor.

  7. Timing subsystem development: Network synchronization experiments

    Science.gov (United States)

    Backe, K. R.

    1983-01-01

    This paper describes a program in which several experimental timing subsystem prototypes were designed, fabricated, and field tested using a small network of troposcatter and microwave digital communication links. This equipment was responsible for modem/radio interfacing, time interval measurement, clock adjustment and distribution, synchronization technique, and node to node information exchange. Presented are discussions of the design approach, measurement plan, and performance assessment methods. Recommendations are made based on the findings of the test program and an evaluation of the design of both the hardware and software elements of the timing subsystem prototypes.

  8. Development and Analysis of a VANET Network

    OpenAIRE

    Corral Zapata, Adrian

    2017-01-01

    Se denomina red vehicular ad hoc (en inglés Vehicular Ad Hoc Network, VANET) a una red de comunicación inalámbrica para la transmisión de información entre vehículos y elementos de la infraestructura de la carretera. La tecnología utilizada se engloba dentro de los sistemas inteligentes de transporte (en inglés Intelligent Transport Systems, ITS). El objetivo principal de las redes de comunicación vehiculares son la transmisión de información útil entre los elementos presentes en la carretera...

  9. THE DISTRIBUTION NETWORK DEVELOPEMENT IN PRINT MEDIA

    Directory of Open Access Journals (Sweden)

    Loredana Iordache

    2012-09-01

    Full Text Available In this article, we identify the characteristics of the distribution networks in print media and the features ofmarketing in mass media, emphasising the attempts initiated by the press in the context of the financial crisis. Theresearch was conducted through a case study on regional newspaper,, Gazeta de Sud'' The main problems analyzedwere decreasing newspaper circulation and advertising. The research taken into account trends and developmentsworldwide print media as well as print media particularities of Romania, with a focus on identifying factors thatcontributed to the closure of a significant number of newspapers, or their transition from printed version online format.The paper is mainly focused on some practical issues related to the way of organizing the print media sales networks,the authors elaborating proposals for the implementation of certain measures to increase the circulation, on the onehand, and on the hand, to increase the sale of ad space in the newspaper. Compared with other products, thenewspaper has unique characteristics caused by daily changing content, and therefore the product itself. Having ahighly perishable, the content of media products should always seen in relation to time, which requires more rapiddistribution and continuous production.

  10. 735 kV air-blast circuit breakers for Hydro Quebec

    Energy Technology Data Exchange (ETDEWEB)

    Lindstrom, I

    1966-01-01

    In 1962 the Quebec Hydro-Electric Commission started the development of aproject for utilizing water power in Manicouagan and Outardes, two rivers some 350 miles northeast of the city of Montreal on the left bank of the St. Lawrence estuary. The project involved the transmission of power at 735 kV ac from Manicouagan and Outardes to the heavy and growing load centers of Quebec and Montreal. The total amount of energy to be transmitted in the final stage is about 6,000 MW. The project involved the need of considerable quantities of apparatus for 735 kV, such as transformers, reactors, lightning arrestors, circuit-breakers, and disconnectors. Since the supply of the major part of the 735 kV circuit-breakers, altogether 14 three-pole units, was awarded to ASEA in Sweden, a short presentation of these airblast circuit-breakers is presented.

  11. Quantum neural networks: Current status and prospects for development

    Science.gov (United States)

    Altaisky, M. V.; Kaputkina, N. E.; Krylov, V. A.

    2014-11-01

    The idea of quantum artificial neural networks, first formulated in [34], unites the artificial neural network concept with the quantum computation paradigm. Quantum artificial neural networks were first systematically considered in the PhD thesis by T. Menneer (1998). Based on the works of Menneer and Narayanan [42, 43], Kouda, Matsui, and Nishimura [35, 36], Altaisky [2, 68], Zhou [67], and others, quantum-inspired learning algorithms for neural networks were developed, and are now used in various training programs and computer games [29, 30]. The first practically realizable scaled hardware-implemented model of the quantum artificial neural network is obtained by D-Wave Systems, Inc. [33]. It is a quantum Hopfield network implemented on the basis of superconducting quantum interference devices (SQUIDs). In this work we analyze possibilities and underlying principles of an alternative way to implement quantum neural networks on the basis of quantum dots. A possibility of using quantum neural network algorithms in automated control systems, associative memory devices, and in modeling biological and social networks is examined.

  12. High power cable with internal water cooling 400 kV

    Energy Technology Data Exchange (ETDEWEB)

    Rasquin, W; Harjes, B

    1982-08-01

    The project was planned for a duration of 4 years. Afterwards it has been extended over 6 years and finally stopped after 3 1/2 years. Therefore, of course results of field tests with an internally cooled 400 kV cable are not available. Nevertheless, this conductor cooled high power cable has been developed to such an extend, that this manufactured cable could withstand type tests according to IEC/VDE recommendations. Even by missing field tests it is obvious that a high power cable for 400 kV is available.

  13. Development of global cortical networks in early infancy.

    Science.gov (United States)

    Homae, Fumitaka; Watanabe, Hama; Otobe, Takayuki; Nakano, Tamami; Go, Tohshin; Konishi, Yukuo; Taga, Gentaro

    2010-04-07

    Human cognition and behaviors are subserved by global networks of neural mechanisms. Although the organization of the brain is a subject of interest, the process of development of global cortical networks in early infancy has not yet been clarified. In the present study, we explored developmental changes in these networks from several days to 6 months after birth by examining spontaneous fluctuations in brain activity, using multichannel near-infrared spectroscopy. We set up 94 measurement channels over the frontal, temporal, parietal, and occipital regions of the infant brain. The obtained signals showed complex time-series properties, which were characterized as 1/f fluctuations. To reveal the functional connectivity of the cortical networks, we calculated the temporal correlations of continuous signals between all the pairs of measurement channels. We found that the cortical network organization showed regional dependency and dynamic changes in the course of development. In the temporal, parietal, and occipital regions, connectivity increased between homologous regions in the two hemispheres and within hemispheres; in the frontal regions, it decreased progressively. Frontoposterior connectivity changed to a "U-shaped" pattern within 6 months: it decreases from the neonatal period to the age of 3 months and increases from the age of 3 months to the age of 6 months. We applied cluster analyses to the correlation coefficients and showed that the bilateral organization of the networks begins to emerge during the first 3 months of life. Our findings suggest that these developing networks, which form multiple clusters, are precursors of the functional cerebral architecture.

  14. Self-organized criticality in developing neuronal networks.

    Directory of Open Access Journals (Sweden)

    Christian Tetzlaff

    Full Text Available Recently evidence has accumulated that many neural networks exhibit self-organized criticality. In this state, activity is similar across temporal scales and this is beneficial with respect to information flow. If subcritical, activity can die out, if supercritical epileptiform patterns may occur. Little is known about how developing networks will reach and stabilize criticality. Here we monitor the development between 13 and 95 days in vitro (DIV of cortical cell cultures (n = 20 and find four different phases, related to their morphological maturation: An initial low-activity state (≈19 DIV is followed by a supercritical (≈20 DIV and then a subcritical one (≈36 DIV until the network finally reaches stable criticality (≈58 DIV. Using network modeling and mathematical analysis we describe the dynamics of the emergent connectivity in such developing systems. Based on physiological observations, the synaptic development in the model is determined by the drive of the neurons to adjust their connectivity for reaching on average firing rate homeostasis. We predict a specific time course for the maturation of inhibition, with strong onset and delayed pruning, and that total synaptic connectivity should be strongly linked to the relative levels of excitation and inhibition. These results demonstrate that the interplay between activity and connectivity guides developing networks into criticality suggesting that this may be a generic and stable state of many networks in vivo and in vitro.

  15. 250 kV 6 mA compact Cockcroft-Walton high-voltage power supply

    Energy Technology Data Exchange (ETDEWEB)

    Ma, Zhan-Wen; Su, Xiao-Dong; Wei, Zhen; Huang, Zhi-Wu; Miao, Tian-You; Su, Tong-Ling [School of Nuclear Science and Technology, Lanzhou University, Lanzhou 730000 (China); Lu, Xiao-Long; Wang, Jun-Run; Yao, Ze-En, E-mail: zeyao@lzu.edu.cn [School of Nuclear Science and Technology, Lanzhou University, Lanzhou 730000 (China); Engineering Research Center for Neutron Application, Ministry of Education, Lanzhou University, Lanzhou 730000 (China)

    2016-08-15

    A compact power supply system for a compact neutron generator has been developed. A 4-stage symmetrical Cockcroft-Walton circuit is adopted to produce 250 kV direct current high-voltage. A 2-stage 280 kV isolation transformer system is used to drive the ion source power supply. For a compact structure, safety, and reliability during the operation, the Cockcroft-Walton circuit and the isolation transformer system are enclosed in an epoxy vessel containing the transformer oil whose size is about ∅350 mm × 766 mm. Test results indicate that the maximum output voltage of the power supply is 282 kV, and the stability of the output voltage is better than 0.63% when the high voltage power supply is operated at 250 kV, 6.9 mA with the input voltage varying ±10%.

  16. The development of medical networks through ICT in Japan

    Directory of Open Access Journals (Sweden)

    Tsutomu Nakamura

    2016-09-01

    Full Text Available This paper examines how medical networks using Information and Communications Technology (ICT have been constructed, and what kind of spatial impact they have on the existing medical care provision system. The results are reported below. In Japan, each prefecture implements its own regional health care program for the appropriate allocation of medical resources. However, regional disparities in such allocation have not yet been resolved. ICT applied to two cases (the Wakashio Medical Network in Chiba Prefecture and the Haniwa Health and Welfare Network in Miyazaki Prefecture has promoted functional division and cooperation among medical institutions as well as the efficient use of resources on medical networks. Factors contributing to the construction of these networks and their continued utilization include strong leadership of central hospitals in the regions, and the fact that they have managed to solve problems related to system development and operation costs. However, differences in medical network awareness between doctors and patients, as well as the constraints of network maintenance costs, force participating doctors in ICT field. In this way, medical networks become a way to complement existing medical delivery systems.

  17. Molecular and functional characterization of Kv7 K+ channel in murine gastrointestinal smooth muscles

    DEFF Research Database (Denmark)

    Jepps, Thomas Andrew; Greenwood, Iain A; Moffatt, James D

    2009-01-01

    that K(v)7.x especially K(v)7.4 and K(v)7.5 are expressed in different regions of the murine gastrointestinal tract and blockers of K(v)7 channels augment inherent contractile activity. Drugs that selectively block K(v)7.4/7.5 might be promising therapeutics for the treatment of motility disorders...

  18. Brain anatomical networks in early human brain development.

    Science.gov (United States)

    Fan, Yong; Shi, Feng; Smith, Jeffrey Keith; Lin, Weili; Gilmore, John H; Shen, Dinggang

    2011-02-01

    Recent neuroimaging studies have demonstrated that human brain networks have economic small-world topology and modular organization, enabling efficient information transfer among brain regions. However, it remains largely unknown how the small-world topology and modular organization of human brain networks emerge and develop. Using longitudinal MRI data of 28 healthy pediatric subjects, collected at their ages of 1 month, 1 year, and 2 years, we analyzed development patterns of brain anatomical networks derived from morphological correlations of brain regional volumes. The results show that the brain network of 1-month-olds has the characteristically economic small-world topology and nonrandom modular organization. The network's cost efficiency increases with the brain development to 1 year and 2 years, so does the modularity, providing supportive evidence for the hypothesis that the small-world topology and the modular organization of brain networks are established during early brain development to support rapid synchronization and information transfer with minimal rewiring cost, as well as to balance between local processing and global integration of information. Copyright © 2010. Published by Elsevier Inc.

  19. Analysis of the partnership network in the clean development mechanism

    International Nuclear Information System (INIS)

    Kang, Moon Jung; Park, Jihyoun

    2013-01-01

    The clean development mechanism (CDM) is a global collaborative action proposed at the Kyoto Protocol in response to climate change issues. The CDM contributes to cost-efficient reduction of greenhouse gas emissions in industrialized countries and promotes sustainable development in developing countries. Its fundamental framework is based on partnerships between industrialized and developing countries. This study employs social network analysis to investigate the dynamics of the partnership networks observed in 3816 CDM projects registered in the database of the United Nations Framework Convention on Climate Change over the period of 2005 to 2011. Our three main findings can be summarized as follows. First, the CDM partnership network is a small world; however, its density tends to decrease as the number of participants for a CDM project decreases. Second, the partnership networks’ leading groups tend to shift from partner countries into host countries. Third, a host country that pursues more partnership-based projects takes better control of resources and knowledge-flow in the ego-network formed around that country, and can thus better utilize global resources for its CDM projects. - Highlights: ► We investigate dynamics of the international partnership networks of CDM projects. ► The density of CDM networks tends to decrease by time. ► The partnership networks’ leading groups tend to shift into host countries. ► A host country with more partnerships better utilizes global knowledge resources.

  20. The 150 kV cp microfocus X-ray unit

    NARCIS (Netherlands)

    Fontijn, L.A.

    1979-01-01

    Development of microfocus X-ray technique is defined. Advantages on other methods, principle of operation and the material comprising an intense electron source imaged on an X-ray target by means of a double magnetic lense system, are described. Resolution value at 150 kV is the imaging of a 0.1 mm

  1. Electronics system for the 150 kV negative ion test stand at BNL

    International Nuclear Information System (INIS)

    Larson, R.A.

    1977-01-01

    The 150 kV test stand at BNL is being used to investigate the extraction, acceleration and transport problems associated with the development of intense negative ion beams. The power supplies associated with these functions as well as the control and monitoring electronics are described

  2. Developed hydraulic simulation model for water pipeline networks

    Directory of Open Access Journals (Sweden)

    A. Ayad

    2013-03-01

    Full Text Available A numerical method that uses linear graph theory is presented for both steady state, and extended period simulation in a pipe network including its hydraulic components (pumps, valves, junctions, etc.. The developed model is based on the Extended Linear Graph Theory (ELGT technique. This technique is modified to include new network components such as flow control valves and tanks. The technique also expanded for extended period simulation (EPS. A newly modified method for the calculation of updated flows improving the convergence rate is being introduced. Both benchmarks, ad Actual networks are analyzed to check the reliability of the proposed method. The results reveal the finer performance of the proposed method.

  3. Methods for calculation of undelivered electricity in medium voltage network that is not integrated into the remote control system

    Directory of Open Access Journals (Sweden)

    Vrcelj Nada

    2013-01-01

    Full Text Available The method is based on data obtained from the so-called. hand-held measuring current at 10 kV voltage level and from reports of outages at reclosers that are installed in a part of network that is observed. At first, is calculates the electrical load of the main distribution power lines, and then simulates the corresponding power flow and calculates the undelivered electricity. The method was applied to parts of the network PD ED Belgrade that are not in the remote control system and is developed for the purpose of considering the effects of automation in the 10 kV PD ED Belgrade.

  4. Development of Novel Random Network Theory-Based Approaches to Identify Network Interactions among Nitrifying Bacteria

    Energy Technology Data Exchange (ETDEWEB)

    Shi, Cindy

    2015-07-17

    The interactions among different microbial populations in a community could play more important roles in determining ecosystem functioning than species numbers and their abundances, but very little is known about such network interactions at a community level. The goal of this project is to develop novel framework approaches and associated software tools to characterize the network interactions in microbial communities based on high throughput, large scale high-throughput metagenomics data and apply these approaches to understand the impacts of environmental changes (e.g., climate change, contamination) on network interactions among different nitrifying populations and associated microbial communities.

  5. Lifelong learning networks for sustainable regional development

    NARCIS (Netherlands)

    De Kraker, Joop; Cörvers, Ron; Ruelle, Christine; Valkering, Pieter

    2010-01-01

    Sustainable regional development is a participatory, multi-actor process, involving a diversity of societal stakeholders, administrators, policy makers, practitioners and scientific experts. In this process, mutual and collective learning plays a major role as participants have to exchange and

  6. South Asian Network for Development and Environmental ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    SANDEE) seeks to build research capacity in the area of poverty, economic development and environmental change in Bangladesh, Bhutan, India, Nepal, Pakistan, the Maldives and Sri Lanka. It does so through research, training, policy dialogue, ...

  7. Developer Network : Open Source Personal Digital Assistant ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Each project used a different software, however, and this proved costly in terms of ... development and evaluation of PDACT, a Palm TM pilot interviewing system ... IWRA/IDRC webinar on climate change and adaptive water management.

  8. Space station common module network topology and hardware development

    Science.gov (United States)

    Anderson, P.; Braunagel, L.; Chwirka, S.; Fishman, M.; Freeman, K.; Eason, D.; Landis, D.; Lech, L.; Martin, J.; Mccorkle, J.

    1990-01-01

    Conceptual space station common module power management and distribution (SSM/PMAD) network layouts and detailed network evaluations were developed. Individual pieces of hardware to be developed for the SSM/PMAD test bed were identified. A technology assessment was developed to identify pieces of equipment requiring development effort. Equipment lists were developed from the previously selected network schematics. Additionally, functional requirements for the network equipment as well as other requirements which affected the suitability of specific items for use on the Space Station Program were identified. Assembly requirements were derived based on the SSM/PMAD developed requirements and on the selected SSM/PMAD network concepts. Basic requirements and simplified design block diagrams are included. DC remote power controllers were successfully integrated into the DC Marshall Space Flight Center breadboard. Two DC remote power controller (RPC) boards experienced mechanical failure of UES 706 stud-mounted diodes during mechanical installation of the boards into the system. These broken diodes caused input to output shorting of the RPC's. The UES 706 diodes were replaced on these RPC's which eliminated the problem. The DC RPC's as existing in the present breadboard configuration do not provide ground fault protection because the RPC was designed to only switch the hot side current. If ground fault protection were to be implemented, it would be necessary to design the system so the RPC switched both the hot and the return sides of power.

  9. Analysis of the 35 KV substation secondary system

    Science.gov (United States)

    Zhao, Yong; Jiang, Jianguo; Jiang, Chunlei; Ren, Shuang; Liu, Songbin

    2017-04-01

    This paper analyzes the status of the two system of some 35KV users' substation in Daqing oil field, the deficiencies of the two system of the existing 35KV substation are found out. And put forward the opinion of acceptance in the future work. I hope it can able to work in the future on the protection of professional help.

  10. On the rationality of network development : the case of the Belgian highway network

    OpenAIRE

    Vanoutrive, Thomas; Damme, Van, Ilja; De Block, Greet

    2016-01-01

    Abstract: The development of transport networks has been explained, predicted and planned using a variety of methodological approaches. These range from narrative historical accounts to the application of models borrowed from the natural sciences, the latter being predominant in the field of transport economics. Probably the most remarkable example is the mimicking of highway networks by slime mould in Petri dishes. The aim of this paper is to examine and compare methods used to hypothesise o...

  11. Social networks and expertise development for Australian breast radiologists.

    Science.gov (United States)

    Taba, Seyedamir Tavakoli; Hossain, Liaquat; Willis, Karen; Lewis, Sarah

    2017-02-11

    In this study, we explore the nexus between social networks and expertise development of Australian breast radiologists. Background literature has shown that a lack of appropriate social networks and interaction among certain professional group(s) may be an obstacle for knowledge acquisition, information flow and expertise sharing. To date there have not been any systematic studies investigating how social networks and expertise development are interconnected and whether this leads to improved performance for breast radiologists. This study explores the value of social networks in building expertise alongside with other constructs of performance for the Australian radiology workforce using semi-structured in-depth interviews with 17 breast radiologists. The findings from this study emphasise the influences of knowledge transfer and learning through social networks and interactions as well as knowledge acquisition and development through experience and feedback. The results also show that accessibility to learning resources and a variety of timely feedback on performance through the information and communication technologies (ICT) is likely to facilitate improved performance and build social support. We argue that radiologists' and, in particular, breast radiologists' work performance, needs to be explored not only through individual numerical characteristics but also by analysing the social context and peer support networks in which they operate and we identify multidisciplinary care as a core entity of social learning.

  12. Networking Skills as a Career Development Practice: Lessons from the Earth Science Women's Network (ESWN)

    Science.gov (United States)

    Hastings, M. G.; Kontak, R.; Holloway, T.; Marin-Spiotta, E.; Steiner, A. L.; Wiedinmyer, C.; Adams, A. S.; de Boer, A. M.; Staudt, A. C.; Fiore, A. M.

    2010-12-01

    Professional networking is often cited as an important component of scientific career development, yet there are few resources for early career scientists to develop and build networks. Personal networks can provide opportunities to learn about organizational culture and procedures, expectations, advancement opportunities, and best practices. They provide access to mentors and job placement opportunities, new scientific collaborations, speaker and conference invitations, increased scientific visibility, reduced isolation, and a stronger feeling of community. There is evidence in the literature that a sense of community positively affects the engagement and retention of underrepresented groups, including women, in science. Thus women scientists may particularly benefit from becoming part of a network. The Earth Science Women’s Network (ESWN) began in 2002 as an informal peer-to-peer mentoring initiative among a few recent Ph.D.s. The network has grown exponentially to include over 1000 women scientists across the globe. Surveys of our membership about ESWN report positive impacts on the careers of women in Earth sciences, particularly those in early career stages. Through ESWN, women share both professional and personal advice, establish research collaborations, communicate strategies on work/life balance, connect with women at various stages of their careers, and provide perspectives from cultures across the globe. We present lessons learned through the formal and informal activities promoted by ESWN in support of the career development of women Earth scientists.

  13. Virtual learning networks for sustainable development

    NARCIS (Netherlands)

    De Kraker, Joop; Cörvers, Ron

    2010-01-01

    Sustainable development is a participatory, multi-actor process. In this process, learning plays a major role as participants have to exchange and integrate a diversity of perspectives and types of knowledge and expertise in order to arrive at innovative, jointly supported solutions. Virtual

  14. Open Development: Networked Innovations in International ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2013-12-12

    Dec 12, 2013 ... Open development harnesses this power to create new organizational ... of applications of openness, addressing challenges as well as opportunities. ... research, improving education, and access to scholarly publications. ... Call for new OWSD Fellowships for Early Career Women Scientists now open.

  15. Open Development: Networked Innovations in International ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Principles travel, the exact models don't—either between contexts or domains. ..... In Canada, an open data policy helped the government recover $3.2 billion in taxes, ... Growth of openness practices is arguably part of “a more widespread ...... Other developing nations and consortia of nations including India, Malaysia, the ...

  16. Developer Network : Open Source Personal Digital Assistant ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Articles de revue. Handheld computers for survey and trial data collection in resource-poor settings : development and evaluation of PDACT, a Palm TM pilot interviewing system ... L'Initiative des conseils subventionnaires de la recherche scientifique en Afrique subsaharienne remporte le prix de la diplomatie scientifique.

  17. Network dynamics in the healthy and epileptic developing brain

    Directory of Open Access Journals (Sweden)

    Richard Rosch

    2018-03-01

    Full Text Available Electroencephalography (EEG allows recording of cortical activity at high temporal resolution. EEG recordings can be summarized along different dimensions using network-level quantitative measures, such as channel-to-channel correlation, or band power distributions across channels. These reveal network patterns that unfold over a range of different timescales and can be tracked dynamically. Here we describe the dynamics of network state transitions in EEG recordings of spontaneous brain activity in normally developing infants and infants with severe early infantile epileptic encephalopathies (n = 8, age: 1–8 months. We describe differences in measures of EEG dynamics derived from band power, and correlation-based summaries of network-wide brain activity. We further show that EEGs from different patient groups and controls may be distinguishable on a small set of the novel quantitative measures introduced here, which describe dynamic network state switching. Quantitative measures related to the sharpness of switching from one correlation pattern to another show the largest differences between groups. These findings reveal that the early epileptic encephalopathies are associated with characteristic dynamic features at the network level. Quantitative network-based analyses like the one presented here may in the future inform the clinical use of quantitative EEG for diagnosis.

  18. Social Network Analysis Identifies Key Participants in Conservation Development.

    Science.gov (United States)

    Farr, Cooper M; Reed, Sarah E; Pejchar, Liba

    2018-05-01

    Understanding patterns of participation in private lands conservation, which is often implemented voluntarily by individual citizens and private organizations, could improve its effectiveness at combating biodiversity loss. We used social network analysis (SNA) to examine participation in conservation development (CD), a private land conservation strategy that clusters houses in a small portion of a property while preserving the remaining land as protected open space. Using data from public records for six counties in Colorado, USA, we compared CD participation patterns among counties and identified actors that most often work with others to implement CDs. We found that social network characteristics differed among counties. The network density, or proportion of connections in the network, varied from fewer than 2 to nearly 15%, and was higher in counties with smaller populations and fewer CDs. Centralization, or the degree to which connections are held disproportionately by a few key actors, was not correlated strongly with any county characteristics. Network characteristics were not correlated with the prevalence of wildlife-friendly design features in CDs. The most highly connected actors were biological and geological consultants, surveyors, and engineers. Our work demonstrates a new application of SNA to land-use planning, in which CD network patterns are examined and key actors are identified. For better conservation outcomes of CD, we recommend using network patterns to guide strategies for outreach and information dissemination, and engaging with highly connected actor types to encourage widespread adoption of best practices for CD design and stewardship.

  19. Development of a UNIX network compatible reactivity computer

    International Nuclear Information System (INIS)

    Sanchez, R.F.; Edwards, R.M.

    1996-01-01

    A state-of-the-art UNIX network compatible controller and UNIX host workstation with MATLAB/SIMULINK software were used to develop, implement, and validate a digital reactivity calculation. An objective of the development was to determine why a Macintosh-based reactivity computer reactivity output drifted intolerably

  20. INFORMATION SYSTEM OF AIRPORT NETWORK DEVELOPMENT MONITORING FORMATION

    Directory of Open Access Journals (Sweden)

    Oleg Smirnov

    2015-07-01

    Full Text Available The article analyzes the approaches to the development of information system in public administration of this important branch of transport civil aviation. In particular, it is shown that the application of algorithmic elements allows to increase the objectivity and transparency when making decisions regarding the regulation of development of the airport network.

  1. Full Scale Test on a 100km, 150kV AC Cable

    DEFF Research Database (Denmark)

    Faria da Silva, Filipe Farria; Wiechowski, W.; Bak, Claus Leth

    2010-01-01

    phenomena is conducted. The cases analysed in this paper are: Zero-missing phenomenon, Ferranti effect, energisation transient, effect of the cable's connection in the busbar voltage and cable disconnection. For all the phenomena described in the paper measurement data are presented and it is verified......This paper presents some of the results obtained from the electrical measurements on a 99.7 km, 150 kV three-phase AC cable, connecting 215 MW offshore wind farm Horns Rev 2, located in Denmark west coast, to Denmark's 400 kV transmission network. The measurements were performed at nominal voltage...... if the obtained results are in accordance with the theory and also with simulations performed in PSCAD/EMTDC. With the exception of the cable disconnection, for all the remaining cases introduced in this paper the measurements confirmed the theoretical expectations. Depending on the cable disconnection sequence...

  2. The C-terminus SH3-binding domain of Kv1.3 is required for the actin-mediated immobilization of the channel via cortactin

    Science.gov (United States)

    Hajdu, Peter; Martin, Geoffrey V.; Chimote, Ameet A.; Szilagyi, Orsolya; Takimoto, Koichi; Conforti, Laura

    2015-01-01

    Kv1.3 channels play a pivotal role in the activation and migration of T-lymphocytes. These functions are accompanied by the channels' polarization, which is essential for associated downstream events. However, the mechanisms that govern the membrane movement of Kv1.3 channels remain unclear. F-actin polymerization occurs concomitantly to channel polarization, implicating the actin cytoskeleton in this process. Here we show that cortactin, a factor initiating the actin network, controls the membrane mobilization of Kv1.3 channels. FRAP with EGFP-tagged Kv1.3 channels demonstrates that knocking down cortactin decreases the actin-based immobilization of the channels. Using various deletion and mutation constructs, we show that the SH3 motif of Kv1.3 mediates the channel immobilization. Proximity ligation assays indicate that deletion or mutation of the SH3 motif also disrupts interaction of the channel with cortactin. In T-lymphocytes, the interaction between HS1 (the cortactin homologue) and Kv1.3 occurs at the immune synapse and requires the channel's C-terminal domain. These results show that actin dynamics regulates the membrane motility of Kv1.3 channels. They also provide evidence that the SH3 motif of the channel and cortactin plays key roles in this process. PMID:25739456

  3. Network data analysis server (NDAS) prototype development

    International Nuclear Information System (INIS)

    Marka, Szabolcs; Mours, Benoit; Williams, Roy

    2002-01-01

    We have developed a simple and robust system based on standard UNIX tools and frame library code to transfer and merge data from multiple gravitational wave detectors distributed worldwide. The transfer and merger take place with less than 20 minute delay and the output frames are available for all participants. Presently VIRGO and LIGO participate in the exchange and only environmental data are shared. The system is modular to allow future improvements and the use of new tools like Grid

  4. Networking - The Urban and Regional Development Strategy?

    OpenAIRE

    Maria Nowicka-Skowron; Piotr Pachura

    2008-01-01

    It has become more and more common to claim that the concept of innovations embraces everything that is connected with creation and application of new knowledge in order to win competitive advantage. In this respect innovations concern as well, apart from technology, economy, society and culture. A traditional approach applied by organizational and management sciences is not enough to explain and manage the development of enterprises as well as that of cities, regions and countries. Simultane...

  5. NETWORKING - THE URBAN AND REGIONAL DEVELOPMENT STRATEGY?

    OpenAIRE

    MARIA NOWICKA-SKOWRON; DEJAN ERIĆ; IVONNE GRABARA; IOAN COSMESCU

    2011-01-01

    The concept of innovations embraces everything that is connected with creation and application of new knowledge in order to win competitive advantage. A traditional approach applied by organizational and management sciences are not enough to explain and manage the development of enterprises as well as that of cities, regions and countries. According to a new approach to innovativeness, creation of innovations depends on a complex/system approach. A phenomenon of particular importance is the a...

  6. Development of nuclear power plant diagnosis technique using neural networks

    International Nuclear Information System (INIS)

    Horiguchi, Masahiro; Fukawa, Naohiro; Nishimura, Kazuo

    1991-01-01

    A nuclear power plant diagnosis technique has been developed, called transient phenomena analysis, which employs neural network. The neural networks identify malfunctioning equipment by recognizing the pattern of main plant parameters, making it possible to locate the cause of an abnormality when a plant is in a transient state. In a case where some piece of equipment shows abnormal behavior, many plant parameters either directly or indirectly related to that equipment change simultaneously. When an abrupt change in a plant parameter is detected, changes in the 49 main plant parameters are classified into three types and a characteristic change pattern consisting of 49 data is defined. The neural networks then judge the cause of the abnormality from this pattern. This neural-network-based technique can recognize 100 patterns that are characterized by the causes of plant abnormality. (author)

  7. Ten-year scheme of network development - 2013 edition

    International Nuclear Information System (INIS)

    2013-01-01

    RTE, an independent subsidiary of EDF, is the French electricity transmission system operator. It is a public service company responsible for operating, maintaining and developing the high and extra high voltage network. It guarantees the reliability and proper operation of the power network. RTE transports electricity between electricity suppliers (French and European) and consumers, whether they are electricity distributors or industrial consumers directly connected to the transmission system. The mission of RTE is to balance the electricity supply and demand in real time. With the support of the government authorities, RTE prepares a ten-year scheme of network development in France; This document presents the main electricity transport infrastructures to foresee within the ten coming years and lists the network development investments which must be realised and implemented within 3 years. The document is updated each year and comes to complement at the national level the European ten year network development plan (TYNDP) and the European regional plans as provided for in the 2009/72/CE European directive

  8. 2012 Ten-year scheme of network development

    International Nuclear Information System (INIS)

    2012-01-01

    RTE, an independent subsidiary of EDF, is the French electricity transmission system operator. It is a public service company responsible for operating, maintaining and developing the high and extra high voltage network. It guarantees the reliability and proper operation of the power network. RTE transports electricity between electricity suppliers (French and European) and consumers, whether they are electricity distributors or industrial consumers directly connected to the transmission system. The mission of RTE is to balance the electricity supply and demand in real time. With the support of the government authorities, RTE prepares a ten-year scheme of network development in France; This document presents the main electricity transport infrastructures to foresee within the ten coming years and lists the network development investments which must be realised and implemented within 3 years. The document is updated each year and comes to complement at the national level the European ten year network development plan (TYNDP) and the European regional plans as provided for in the 2009/72/CE European directive

  9. Ten-year scheme of network development - 2011

    International Nuclear Information System (INIS)

    2011-01-01

    RTE, an independent subsidiary of EDF, is the French electricity transmission system operator. It is a public service company responsible for operating, maintaining and developing the high and extra high voltage network. It guarantees the reliability and proper operation of the power network. RTE transports electricity between electricity suppliers (French and European) and consumers, whether they are electricity distributors or industrial consumers directly connected to the transmission system. The mission of RTE is to balance the electricity supply and demand in real time. With the support of the government authorities, RTE prepares a ten-year scheme of network development in France; This document presents the main electricity transport infrastructures to foresee within the ten coming years and lists the network development investments which must be realised and implemented within 3 years. The document is updated each year and comes to complement at the national level the European ten year network development plan (TYNDP) and the European regional plans as provided for in the 2009/72/CE European directive

  10. Beam Extraction for 1-MV Electrostatic Accelerator at the 300 kV Test Stand

    Energy Technology Data Exchange (ETDEWEB)

    Park, Sae-Hoon; Kim, Yu-Seok [Dongguk University, Seoul (Korea, Republic of); Kwon, Hyeok-Jung; Cho, Yong-Sub [KOMAC, Gyeongju (Korea, Republic of)

    2015-05-15

    The Korea Multipurpose Accelerator Complex (KOMAC) has been developing a 300-kV test stand for a 1-MV electrostatic accelerator ion source. The ion source in the high-pressure vessel is required to have a high reliability. The test stand has been proposed and developed to confirm the stable operating conditions of the ion source. The ion source will be tested at the test stand to verify the long-time operating conditions. The test stand comprises a 300-kV high-voltage terminal, a battery for the ion-source power, a 60-Hz inverter, 200-MHz RF power, a 5-kV extraction power supply, a 300-kV accelerating tube, and a vacuum system. A beam extraction experiment for the test stand was performed, and the beam current was measured using a faraday cup in the chamber. A beam extraction results for the RF ion source will be presented. Beam extraction from the RF ion source of the test stand is verified by measuring the beam current with a faraday cup in the chamber. Thus far NI Labview, PLC and faraday cup have been used to measure the beam current. The OPC server is useful for monitoring the PLC values. The average beam current of (a), (b) and (c) shown in figure 2 are 110.241µA, 105.8597µA and 103.5278µA respectively.

  11. 75 FR 57521 - Networking and Information Technology Research and Development (NITRD) Program: Draft NITRD 2010...

    Science.gov (United States)

    2010-09-21

    ... NATIONAL SCIENCE FOUNDATION Networking and Information Technology Research and Development (NITRD...) for Networking and Information Technology Research and Development (NITRD). ACTION: Notice, request.... SUMMARY: With this notice, the National Coordination Office for Networking and Information Technology...

  12. Development of human brain structural networks through infancy and childhood.

    Science.gov (United States)

    Huang, Hao; Shu, Ni; Mishra, Virendra; Jeon, Tina; Chalak, Lina; Wang, Zhiyue J; Rollins, Nancy; Gong, Gaolang; Cheng, Hua; Peng, Yun; Dong, Qi; He, Yong

    2015-05-01

    During human brain development through infancy and childhood, microstructural and macrostructural changes take place to reshape the brain's structural networks and better adapt them to sophisticated functional and cognitive requirements. However, structural topological configuration of the human brain during this specific development period is not well understood. In this study, diffusion magnetic resonance image (dMRI) of 25 neonates, 13 toddlers, and 25 preadolescents were acquired to characterize network dynamics at these 3 landmark cross-sectional ages during early childhood. dMRI tractography was used to construct human brain structural networks, and the underlying topological properties were quantified by graph-theory approaches. Modular organization and small-world attributes are evident at birth with several important topological metrics increasing monotonically during development. Most significant increases of regional nodes occur in the posterior cingulate cortex, which plays a pivotal role in the functional default mode network. Positive correlations exist between nodal efficiencies and fractional anisotropy of the white matter traced from these nodes, while correlation slopes vary among the brain regions. These results reveal substantial topological reorganization of human brain structural networks through infancy and childhood, which is likely to be the outcome of both heterogeneous strengthening of the major white matter tracts and pruning of other axonal fibers. © The Author 2013. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  13. The Medical Library Association Benchmarking Network: development and implementation*

    Science.gov (United States)

    Dudden, Rosalind Farnam; Corcoran, Kate; Kaplan, Janice; Magouirk, Jeff; Rand, Debra C.; Smith, Bernie Todd

    2006-01-01

    Objective: This article explores the development and implementation of the Medical Library Association (MLA) Benchmarking Network from the initial idea and test survey, to the implementation of a national survey in 2002, to the establishment of a continuing program in 2004. Started as a program for hospital libraries, it has expanded to include other nonacademic health sciences libraries. Methods: The activities and timelines of MLA's Benchmarking Network task forces and editorial board from 1998 to 2004 are described. Results: The Benchmarking Network task forces successfully developed an extensive questionnaire with parameters of size and measures of library activity and published a report of the data collected by September 2002. The data were available to all MLA members in the form of aggregate tables. Utilization of Web-based technologies proved feasible for data intake and interactive display. A companion article analyzes and presents some of the data. MLA has continued to develop the Benchmarking Network with the completion of a second survey in 2004. Conclusions: The Benchmarking Network has provided many small libraries with comparative data to present to their administrators. It is a challenge for the future to convince all MLA members to participate in this valuable program. PMID:16636702

  14. The Medical Library Association Benchmarking Network: development and implementation.

    Science.gov (United States)

    Dudden, Rosalind Farnam; Corcoran, Kate; Kaplan, Janice; Magouirk, Jeff; Rand, Debra C; Smith, Bernie Todd

    2006-04-01

    This article explores the development and implementation of the Medical Library Association (MLA) Benchmarking Network from the initial idea and test survey, to the implementation of a national survey in 2002, to the establishment of a continuing program in 2004. Started as a program for hospital libraries, it has expanded to include other nonacademic health sciences libraries. The activities and timelines of MLA's Benchmarking Network task forces and editorial board from 1998 to 2004 are described. The Benchmarking Network task forces successfully developed an extensive questionnaire with parameters of size and measures of library activity and published a report of the data collected by September 2002. The data were available to all MLA members in the form of aggregate tables. Utilization of Web-based technologies proved feasible for data intake and interactive display. A companion article analyzes and presents some of the data. MLA has continued to develop the Benchmarking Network with the completion of a second survey in 2004. The Benchmarking Network has provided many small libraries with comparative data to present to their administrators. It is a challenge for the future to convince all MLA members to participate in this valuable program.

  15. Development of Human Brain Structural Networks Through Infancy and Childhood

    Science.gov (United States)

    Huang, Hao; Shu, Ni; Mishra, Virendra; Jeon, Tina; Chalak, Lina; Wang, Zhiyue J.; Rollins, Nancy; Gong, Gaolang; Cheng, Hua; Peng, Yun; Dong, Qi; He, Yong

    2015-01-01

    During human brain development through infancy and childhood, microstructural and macrostructural changes take place to reshape the brain's structural networks and better adapt them to sophisticated functional and cognitive requirements. However, structural topological configuration of the human brain during this specific development period is not well understood. In this study, diffusion magnetic resonance image (dMRI) of 25 neonates, 13 toddlers, and 25 preadolescents were acquired to characterize network dynamics at these 3 landmark cross-sectional ages during early childhood. dMRI tractography was used to construct human brain structural networks, and the underlying topological properties were quantified by graph-theory approaches. Modular organization and small-world attributes are evident at birth with several important topological metrics increasing monotonically during development. Most significant increases of regional nodes occur in the posterior cingulate cortex, which plays a pivotal role in the functional default mode network. Positive correlations exist between nodal efficiencies and fractional anisotropy of the white matter traced from these nodes, while correlation slopes vary among the brain regions. These results reveal substantial topological reorganization of human brain structural networks through infancy and childhood, which is likely to be the outcome of both heterogeneous strengthening of the major white matter tracts and pruning of other axonal fibers. PMID:24335033

  16. Developments of the general computer network of NIPNE-HH

    International Nuclear Information System (INIS)

    Mirica, M.; Constantinescu, S.; Danet, A.

    1997-01-01

    Since 1991 the general computer network of NIPNE-HH was developed and connected to RNCN (Romanian National Computer Network) for research and development and it offers to the Romanian physics research community an efficient and cost-effective infrastructure to communicate and collaborate with fellow researchers abroad, and to collect and exchange the most up-to-date information in their research area. RNCN is targeted on the following main objectives: Setting up a technical and organizational infrastructure meant to provide national and international electronic services for the Romanian scientific research community; - Providing a rapid and competitive tool for the exchange of information in the framework of Research and Development (R-D) community; - Using the scientific and technical data bases available in the country and offered by the national networks from other countries through international networks; - Providing a support for information, scientific and technical co-operation. RNCN has two international links: to EBONE via ACONET (64kbps) and to EuropaNET via Hungarnet (64 kbps). The guiding principle in designing the project of general computer network of NIPNE-HH, as part of RNCN, was to implement an open system based on OSI standards taking into account the following criteria: - development of a flexible solution, according to OSI specifications; - solutions of reliable gateway with the existing network already in use,allowing the access to the worldwide networks; - using the TCP/IP transport protocol for each Local Area Network (LAN) and for the connection to RNCN; - ensuring the integration of different and heterogeneous software and hardware platforms (DOS, Windows, UNIX, VMS, Linux, etc) through some specific interfaces. The major objectives achieved in direction of developing the general computer network of NIPNE-HH are: - linking all the existing and newly installed computer equipment and providing an adequate connectivity. LANs from departments

  17. Developing a Framework for Effective Network Capacity Planning

    Science.gov (United States)

    Yaprak, Ece

    2005-01-01

    As Internet traffic continues to grow exponentially, developing a clearer understanding of, and appropriately measuring, network's performance is becoming ever more critical. An important challenge faced by the Information Resources Directorate (IRD) at the Johnson Space Center in this context remains not only monitoring and maintaining a secure network, but also better understanding the capacity and future growth potential boundaries of its network. This requires capacity planning which involves modeling and simulating different network alternatives, and incorporating changes in design as technologies, components, configurations, and applications change, to determine optimal solutions in light of IRD's goals, objectives and strategies. My primary task this summer was to address this need. I evaluated network-modeling tools from OPNET Technologies Inc. and Compuware Corporation. I generated a baseline model for Building 45 using both tools by importing "real" topology/traffic information using IRD's various network management tools. I compared each tool against the other in terms of the advantages and disadvantages of both tools to accomplish IRD's goals. I also prepared step-by-step "how to design a baseline model" tutorial for both OPNET and Compuware products.

  18. Optimized energy-delay sub-network routing protocol development and implementation for wireless sensor networks

    International Nuclear Information System (INIS)

    Fonda, James W; Zawodniok, Maciej; Jagannathan, S; Watkins, Steve E

    2008-01-01

    The development and the implementation issues of a reactive optimized energy-delay sub-network routing (OEDSR) protocol for wireless sensor networks (WSN) are introduced and its performance is contrasted with the popular ad hoc on-demand distance vector (AODV) routing protocol. Analytical results illustrate the performance of the proposed OEDSR protocol, while experimental results utilizing a hardware testbed under various scenarios demonstrate improvements in energy efficiency of the OEDSR protocol. A hardware platform constructed at the University of Missouri-Rolla (UMR), now the Missouri University of Science and Technology (MST), based on the Generation 4 Smart Sensor Node (G4-SSN) prototyping platform is also described. Performance improvements are shown in terms of end-to-end (E2E) delay, throughput, route-set-up time and drop rates and energy usage is given for three topologies, including a mobile topology. Additionally, results from the hardware testbed provide valuable lessons for network deployments. Under testing OEDSR provides a factor of ten improvement in the energy used in the routing session and extends network lifetime compared to AODV. Depletion experiments show that the time until the first node failure is extended by a factor of three with the network depleting and network lifetime is extended by 6.7%

  19. Workers exposure to electric fields in 400 kV substations and overhead line works

    International Nuclear Information System (INIS)

    Elovaara, J.; Kuisti, H.; Korpinen, L.

    2010-01-01

    The maximum exposing electric field strength magnitude in the highly inhomogeneous 400 kV electric field under work conditions can reach the value of several tens of kV/m. In spite of this the average current density is, in Finland, always lower than 10 mA/m 2 . Furthermore, the total body currents or contact currents are in 400 kV works clearly less than the limit value proposed by the EU's draft for Directive. On the basis of the obtained results it can be concluded that from the limit value point of view it is not necessary to take further actions to reduce the exposure of the workers when they are working in 400 kV substations and on 400 kV overhead lines. However, because the transient peak values of the contact current can be painful and disturb work, it is advisable to develop a safe and reliable method to connect the worker and the work object in the common ground (equipotential bonding). (authors)

  20. Modification of 300kV RF Ion Source for 1-MV Electrostatic Accelerator at KOMAC

    International Nuclear Information System (INIS)

    Kim, Dae-Il; Kwon, Hyeok-Jung; Park, Sae-Hoon; Cho, Yong-Sub

    2015-01-01

    The specifications of the 1-MV electrostatic accelerator are shown as below. High voltage power supply is electron transformer rectifier (ELV) type which was developed in Nuclear Physics Institute (Novosibirsk) for industrial electron accelerators. And accelerator column consists of alumina and metal electrode rings were 0.5m-long brazed structure which can be installed horizontally. In case of ion source for 1-MV electrostatic accelerator, it is chosen a thonemann type rf ion source and 300-kV test-stand was made up to confirm the stable operating conditions. High voltage power supply is fabricated by domestic company, and its operation has been confirming at KOMAC site. Equally, the ion source of 300-kV test-stand should be modified to install into the high voltage power supply. In this paper, modification of ion source of 300-kV test-stand for 1-MV electrostatic accelerator is presented and its processes are considered. 300-kV RF ion source and power supply are testing for the 1-MV electrostatic accelerator and trying for combination between them. The 1-MV electrostatic accelerator will be fabricated with domestic companies and tested in the beam application research building at KOMAC

  1. Modification of 300kV RF Ion Source for 1-MV Electrostatic Accelerator at KOMAC

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Dae-Il; Kwon, Hyeok-Jung; Park, Sae-Hoon; Cho, Yong-Sub [KOMAC, Gyeongju (Korea, Republic of)

    2015-05-15

    The specifications of the 1-MV electrostatic accelerator are shown as below. High voltage power supply is electron transformer rectifier (ELV) type which was developed in Nuclear Physics Institute (Novosibirsk) for industrial electron accelerators. And accelerator column consists of alumina and metal electrode rings were 0.5m-long brazed structure which can be installed horizontally. In case of ion source for 1-MV electrostatic accelerator, it is chosen a thonemann type rf ion source and 300-kV test-stand was made up to confirm the stable operating conditions. High voltage power supply is fabricated by domestic company, and its operation has been confirming at KOMAC site. Equally, the ion source of 300-kV test-stand should be modified to install into the high voltage power supply. In this paper, modification of ion source of 300-kV test-stand for 1-MV electrostatic accelerator is presented and its processes are considered. 300-kV RF ion source and power supply are testing for the 1-MV electrostatic accelerator and trying for combination between them. The 1-MV electrostatic accelerator will be fabricated with domestic companies and tested in the beam application research building at KOMAC.

  2. Development of target-tracking algorithms using neural network

    Energy Technology Data Exchange (ETDEWEB)

    Park, Dong Sun; Lee, Joon Whaoan; Yoon, Sook; Baek, Seong Hyun; Lee, Myung Jae [Chonbuk National University, Chonjoo (Korea)

    1998-04-01

    The utilization of remote-control robot system in atomic power plants or nuclear-related facilities grows rapidly, to protect workers form high radiation environments. Such applications require complete stability of the robot system, so that precisely tracking the robot is essential for the whole system. This research is to accomplish the goal by developing appropriate algorithms for remote-control robot systems. A neural network tracking system is designed and experimented to trace a robot Endpoint. This model is aimed to utilized the excellent capabilities of neural networks; nonlinear mapping between inputs and outputs, learning capability, and generalization capability. The neural tracker consists of two networks for position detection and prediction. Tracking algorithms are developed and experimented for the two models. Results of the experiments show that both models are promising as real-time target-tracking systems for remote-control robot systems. (author). 10 refs., 47 figs.

  3. Mixed Transportation Network Design under a Sustainable Development Perspective

    Directory of Open Access Journals (Sweden)

    Jin Qin

    2013-01-01

    Full Text Available A mixed transportation network design problem considering sustainable development was studied in this paper. Based on the discretization of continuous link-grade decision variables, a bilevel programming model was proposed to describe the problem, in which sustainability factors, including vehicle exhaust emissions, land-use scale, link load, and financial budget, are considered. The objective of the model is to minimize the total amount of resources exploited under the premise of meeting all the construction goals. A heuristic algorithm, which combined the simulated annealing and path-based gradient projection algorithm, was developed to solve the model. The numerical example shows that the transportation network optimized with the method above not only significantly alleviates the congestion on the link, but also reduces vehicle exhaust emissions within the network by up to 41.56%.

  4. Mixed Transportation Network Design under a Sustainable Development Perspective

    Science.gov (United States)

    Qin, Jin; Ni, Ling-lin; Shi, Feng

    2013-01-01

    A mixed transportation network design problem considering sustainable development was studied in this paper. Based on the discretization of continuous link-grade decision variables, a bilevel programming model was proposed to describe the problem, in which sustainability factors, including vehicle exhaust emissions, land-use scale, link load, and financial budget, are considered. The objective of the model is to minimize the total amount of resources exploited under the premise of meeting all the construction goals. A heuristic algorithm, which combined the simulated annealing and path-based gradient projection algorithm, was developed to solve the model. The numerical example shows that the transportation network optimized with the method above not only significantly alleviates the congestion on the link, but also reduces vehicle exhaust emissions within the network by up to 41.56%. PMID:23476142

  5. Distributed Sensor Network Software Development Testing through Simulation

    Energy Technology Data Exchange (ETDEWEB)

    Brennan, Sean M. [Univ. of New Mexico, Albuquerque, NM (United States)

    2003-12-01

    The distributed sensor network (DSN) presents a novel and highly complex computing platform with dif culties and opportunities that are just beginning to be explored. The potential of sensor networks extends from monitoring for threat reduction, to conducting instant and remote inventories, to ecological surveys. Developing and testing for robust and scalable applications is currently practiced almost exclusively in hardware. The Distributed Sensors Simulator (DSS) is an infrastructure that allows the user to debug and test software for DSNs independent of hardware constraints. The exibility of DSS allows developers and researchers to investigate topological, phenomenological, networking, robustness and scaling issues, to explore arbitrary algorithms for distributed sensors, and to defeat those algorithms through simulated failure. The user speci es the topology, the environment, the application, and any number of arbitrary failures; DSS provides the virtual environmental embedding.

  6. Development of a Testbed for Wireless Underground Sensor Networks

    Directory of Open Access Journals (Sweden)

    Mehmet C. Vuran

    2010-01-01

    Full Text Available Wireless Underground Sensor Networks (WUSNs constitute one of the promising application areas of the recently developed wireless sensor networking techniques. WUSN is a specialized kind of Wireless Sensor Network (WSN that mainly focuses on the use of sensors that communicate through soil. Recent models for the wireless underground communication channel are proposed but few field experiments were realized to verify the accuracy of the models. The realization of field WUSN experiments proved to be extremely complex and time-consuming in comparison with the traditional wireless environment. To the best of our knowledge, this is the first work that proposes guidelines for the development of an outdoor WUSN testbed with the goals of improving the accuracy and reducing of time for WUSN experiments. Although the work mainly aims WUSNs, many of the presented practices can also be applied to generic WSN testbeds.

  7. THE IMPACT OF POVERTY ON THE DEVELOPMENT OF BRAIN NETWORKS

    Directory of Open Access Journals (Sweden)

    Sebastian J Lipina

    2012-08-01

    Full Text Available Although the study of brain development in non-human animals is an old one, recent imaging methods have allowed non-invasive studies of the grey and white matter of the human brain over the lifespan. Classic animal studies show clearly that impoverished environments reduce cortical grey matter in relation to complex environments and cognitive and imaging studies in humans suggest which networks may be most influenced by poverty. Studies have been clear in showing the plasticity of many brain systems, but whether sensitivity to learning differs over the lifespan and for which networks is still unclear. A major task for current research is a successful integration of these methods to understand how development and learning shape the neural networks underlying achievements in literacy, numeracy, and attention. This paper seeks to foster further integration by reviewing the currents state of knowledge relating brain changes to behavior and indicating possible future directions.

  8. METHODOLOGY OF RESEARCH AND DEVELOPMENT MANAGEMENT OF REGIONAL NETWORK ECONOMY

    Directory of Open Access Journals (Sweden)

    O.I. Botkin

    2007-06-01

    Full Text Available Information practically of all the Russian regions economy branches and development by managing subjects is information − communicative the Internet technologies render huge influence on economic attitudes development in the environment of regional business: there are new forms of interaction of managing subjects and change is information − organizational structures of regional business management. Integrated image of the set forth above innovations is the regional network economy representing the interactive environment in which on high speed and with minimal transaction (R.H.Coase’s costs are performed social economic and commodity monetary attitudes between managing subjects of region with use of Internet global network interactive opportunities. The urgency of the regional network economy phenomenon research, first of all, is caused by necessity of a substantiation of regional network economy methodology development and management mechanisms development by its infrastructure with the purpose of regional business efficiency increase. In our opinion, the decision of these problems will be the defining factor of effective economic development maintenance and russian regions economy growth in the near future.

  9. Settlement Networks in Polish Spatial Development Regional Plans

    Science.gov (United States)

    Sołtys, Jacek

    2017-10-01

    In 1999, ten years after the great political changes in Poland, 16 self-governed regions (in Polish: voivodeship) were created. According to Polish law, voivodeship spatial development plans, or regional plans in short, determine basic elements of the settlement network. No detailed regulations indicate the specific elements of the settlement network or what features of these elements should be determined. For this reason, centres as elements of the settlement network are variously named in different regions and take the form of various models. The purposes of the research described in this article are: (1) recognition and systematization of settlement network models determined in regional plans; and (2) assessment of the readability of determination in planning and its usefulness in the practice of regional policy. Six models of settlement networks in regional plans have been identified and classified into types and sub-types. Names of specific levels of centres indicate that they were classified according to two criteria: (1) level of services, which concerns only 5 voivodships; and (2) importance in development, which concerns the 11 other voivodships. The hierarchical model referring to the importance of development is less understandable than the one related to services. In the text of most plans, centres of services and centres of development are treated independently from their names. In some plans the functional types of towns and cities are indicated. In some voivodships, specifications in the plan text are too general and seem to be rather useless in the practice of regional policy. The author suggests that regional plans should determine two kinds of centres: hierarchical service centres and non-hierarchical centres of development. These centres should be further distinguished according to: (1) their role in the activation of surroundings; (2) their level of development and the necessity of action for their development; and (3) the types of actions

  10. Functional brain networks develop from a "local to distributed" organization.

    Directory of Open Access Journals (Sweden)

    Damien A Fair

    2009-05-01

    Full Text Available The mature human brain is organized into a collection of specialized functional networks that flexibly interact to support various cognitive functions. Studies of development often attempt to identify the organizing principles that guide the maturation of these functional networks. In this report, we combine resting state functional connectivity MRI (rs-fcMRI, graph analysis, community detection, and spring-embedding visualization techniques to analyze four separate networks defined in earlier studies. As we have previously reported, we find, across development, a trend toward 'segregation' (a general decrease in correlation strength between regions close in anatomical space and 'integration' (an increased correlation strength between selected regions distant in space. The generalization of these earlier trends across multiple networks suggests that this is a general developmental principle for changes in functional connectivity that would extend to large-scale graph theoretic analyses of large-scale brain networks. Communities in children are predominantly arranged by anatomical proximity, while communities in adults predominantly reflect functional relationships, as defined from adult fMRI studies. In sum, over development, the organization of multiple functional networks shifts from a local anatomical emphasis in children to a more "distributed" architecture in young adults. We argue that this "local to distributed" developmental characterization has important implications for understanding the development of neural systems underlying cognition. Further, graph metrics (e.g., clustering coefficients and average path lengths are similar in child and adult graphs, with both showing "small-world"-like properties, while community detection by modularity optimization reveals stable communities within the graphs that are clearly different between young children and young adults. These observations suggest that early school age children and adults

  11. Functional brain networks develop from a "local to distributed" organization.

    Science.gov (United States)

    Fair, Damien A; Cohen, Alexander L; Power, Jonathan D; Dosenbach, Nico U F; Church, Jessica A; Miezin, Francis M; Schlaggar, Bradley L; Petersen, Steven E

    2009-05-01

    The mature human brain is organized into a collection of specialized functional networks that flexibly interact to support various cognitive functions. Studies of development often attempt to identify the organizing principles that guide the maturation of these functional networks. In this report, we combine resting state functional connectivity MRI (rs-fcMRI), graph analysis, community detection, and spring-embedding visualization techniques to analyze four separate networks defined in earlier studies. As we have previously reported, we find, across development, a trend toward 'segregation' (a general decrease in correlation strength) between regions close in anatomical space and 'integration' (an increased correlation strength) between selected regions distant in space. The generalization of these earlier trends across multiple networks suggests that this is a general developmental principle for changes in functional connectivity that would extend to large-scale graph theoretic analyses of large-scale brain networks. Communities in children are predominantly arranged by anatomical proximity, while communities in adults predominantly reflect functional relationships, as defined from adult fMRI studies. In sum, over development, the organization of multiple functional networks shifts from a local anatomical emphasis in children to a more "distributed" architecture in young adults. We argue that this "local to distributed" developmental characterization has important implications for understanding the development of neural systems underlying cognition. Further, graph metrics (e.g., clustering coefficients and average path lengths) are similar in child and adult graphs, with both showing "small-world"-like properties, while community detection by modularity optimization reveals stable communities within the graphs that are clearly different between young children and young adults. These observations suggest that early school age children and adults both have

  12. Development of the computer network of IFIN-HH

    International Nuclear Information System (INIS)

    Danet, A.; Mirica, M.; Constantinescu, S.

    1998-01-01

    The general computer network of Horia Hulubei National Institute for Physics and Nuclear Engineering (IFIN-HH), as part of RNC (Romanian National Computer Network for scientific research and technological development), offers the Romanian physics research community an efficient and cost-effective infrastructure to communicate and collaborate with fellow researchers abroad, and to collect and exchange the most up-to-date information in their research area. RNC is the national project co-ordinated and established by the Ministry of Research and Technology targeted on the following main objectives: - setting up a technical and organizational infrastructure meant to provide national and international electronic services for the Romanian scientific research community; - providing a rapid and competitive tool for the exchange information in the framework of R-D community; - using the scientific and technical data bases available in the country and offered by the national networks from other countries through international networks; - providing a support for information, documentation, scientific and technical co-operation. The guiding principle in elaborating the project of general computer network of IFIN-HH was to implement an open system based on OSI standards without technical barriers in communication between different communities using different computing hardware and software. The major objectives achieved in 1997 in the direction of developing the general computer network of IFIN-HH (over 250 computers connected) were: - connecting all the existing and newly installed computer equipment and providing an adequate connectivity; - providing the usual Internet services: e-mail, ftp, telnet, finger, gopher; - providing access to the World Wide Web resources; - providing on-line statistics of IP traffic (input and output) of each node of the domain computer network; - improving the performance of the connection with the central node RNC. (authors)

  13. Cooperation and Development: a study of case in network cooperation

    Directory of Open Access Journals (Sweden)

    June Alisson Westarb Cruz

    2009-03-01

    Full Text Available The need to develop new surviving strategies and competitive advantage by individuals and organizations make cooperation to obtain complementary competences and potentialities very important, through the insertion of social actors in multiple networks of relationships and interactions.  This research was made in an Association Network of Carrinheiros[1] located in Curitiba and in the coast of Paraná.  The objective of the study was to analyze the structural characteristics of the network and its implications to develop collective actions. The data was collected through questionnaires, interviews, document analysis, and the daily direct observation of the network.  An interaction system between individuals and organizations from various sectors in society could be verified. This interaction stimulates the structured work connected to associations and cooperatives.  Between the actors of the network, concepts and realities are different, as well as individual objectives are distinct.  However, they converge to a common general objective that establish a common base for collaborative work.

  14. Development of large-scale functional brain networks in children.

    Directory of Open Access Journals (Sweden)

    Kaustubh Supekar

    2009-07-01

    Full Text Available The ontogeny of large-scale functional organization of the human brain is not well understood. Here we use network analysis of intrinsic functional connectivity to characterize the organization of brain networks in 23 children (ages 7-9 y and 22 young-adults (ages 19-22 y. Comparison of network properties, including path-length, clustering-coefficient, hierarchy, and regional connectivity, revealed that although children and young-adults' brains have similar "small-world" organization at the global level, they differ significantly in hierarchical organization and interregional connectivity. We found that subcortical areas were more strongly connected with primary sensory, association, and paralimbic areas in children, whereas young-adults showed stronger cortico-cortical connectivity between paralimbic, limbic, and association areas. Further, combined analysis of functional connectivity with wiring distance measures derived from white-matter fiber tracking revealed that the development of large-scale brain networks is characterized by weakening of short-range functional connectivity and strengthening of long-range functional connectivity. Importantly, our findings show that the dynamic process of over-connectivity followed by pruning, which rewires connectivity at the neuronal level, also operates at the systems level, helping to reconfigure and rebalance subcortical and paralimbic connectivity in the developing brain. Our study demonstrates the usefulness of network analysis of brain connectivity to elucidate key principles underlying functional brain maturation, paving the way for novel studies of disrupted brain connectivity in neurodevelopmental disorders such as autism.

  15. Development of large-scale functional brain networks in children.

    Science.gov (United States)

    Supekar, Kaustubh; Musen, Mark; Menon, Vinod

    2009-07-01

    The ontogeny of large-scale functional organization of the human brain is not well understood. Here we use network analysis of intrinsic functional connectivity to characterize the organization of brain networks in 23 children (ages 7-9 y) and 22 young-adults (ages 19-22 y). Comparison of network properties, including path-length, clustering-coefficient, hierarchy, and regional connectivity, revealed that although children and young-adults' brains have similar "small-world" organization at the global level, they differ significantly in hierarchical organization and interregional connectivity. We found that subcortical areas were more strongly connected with primary sensory, association, and paralimbic areas in children, whereas young-adults showed stronger cortico-cortical connectivity between paralimbic, limbic, and association areas. Further, combined analysis of functional connectivity with wiring distance measures derived from white-matter fiber tracking revealed that the development of large-scale brain networks is characterized by weakening of short-range functional connectivity and strengthening of long-range functional connectivity. Importantly, our findings show that the dynamic process of over-connectivity followed by pruning, which rewires connectivity at the neuronal level, also operates at the systems level, helping to reconfigure and rebalance subcortical and paralimbic connectivity in the developing brain. Our study demonstrates the usefulness of network analysis of brain connectivity to elucidate key principles underlying functional brain maturation, paving the way for novel studies of disrupted brain connectivity in neurodevelopmental disorders such as autism.

  16. Latest developments for a computer aided thermohydraulic network

    International Nuclear Information System (INIS)

    Alemberti, A.; Graziosi, G.; Mini, G.; Susco, M.

    1999-01-01

    Thermohydraulic networks are I-D systems characterized by a small number of basic components (pumps, valves, heat exchangers, etc) connected by pipes and limited spatially by a defined number of boundary conditions (tanks, atmosphere, etc). The network system is simulated by the well known computer program RELAPS/mod3. Information concerning the network geometry component behaviour, initial and boundary conditions are usually supplied to the RELAPS code using an ASCII input file by means of 'input cards'. CATNET (Computer Aided Thermalhydraulic NETwork) is a graphically user interface that, under specific user guidelines which completely define its range of applicability, permits a very high level of standardization and simplification of the RELAPS/mod3 input deck development process as well as of the output processing. The characteristics of the components (pipes, valves, pumps etc), defining the network system can be entered through CATNET. The CATNET interface is provided by special functions to compute form losses in the most typical bending and branching configurations. When the input of all system components is ready, CATNET is able to generate the RELAPS/mod3 input file. Finally, by means of CATNET, the RELAPS/mod3 code can be run and its output results can be transformed to an intuitive display form. The paper presents an example of application of the CATNET interface as well as the latest developments which greatly simplified the work of the users and allowed to reduce the possibility of input errors. (authors)

  17. Solution of K-V envelope equations

    International Nuclear Information System (INIS)

    Anderson, O.A.

    1995-04-01

    The envelope equations for a KV beam with space charge have been analyzed systematically by an e expansion followed by integrations. The focusing profile as a function of axial length is assumed to be symmetric but otherwise arbitrary. Given the bean current, emittance, and peak focusing field, we find the envelopes a(s) and b(s) and obtain , a max , σ, and σ 0 . Explicit results are presented for various truncations of the expansion. The zeroth order results correspond to those from the well-known smooth approximation; the same convenient format is retained for the higher order cases. The first order results, involving single correction terms, give 3--10 times better accuracy and are good to ∼1% at σ 0 = 70 degree. Third order gives a factor of 10--30 improvement over the smooth approximation and derived quantities accurate to ∼1% at σ 0 = 112 degree. The first order expressions are convenient design tools. They lend themselves to variable energy problems and have been applied to the design, construction, and testing of ESQ accelerators at LBL

  18. Development of Tools for DER Components in a Distribution Network

    DEFF Research Database (Denmark)

    Mihet-Popa, Lucian; Koch-Ciobotaru, C; Isleifsson, Fridrik Rafn

    2012-01-01

    The increasing amount of Distributed Energy Resources (DER) components into distribution networks involves the development of accurate simulation models that take into account an increasing number of factors that influence the output power from the DG systems. This paper presents two simulation m...

  19. The Bowie State University Professional Development Schools Network Partnership

    Science.gov (United States)

    Garin, Eva; Taylor, Traki; Madden, Maggie; Beiter, Judy; Davis, Julius; Farmer, Cynthia; Nowlin, Dawn

    2015-01-01

    The Bowie State University PDS Network Partnership is one of the 2015 Exemplary PDS Partnerships recognized by the National Association for Professional Development Schools. This partnership is built on a series of signature programs that define and support our partnership work. This article describes each of those signature programs that make our…

  20. A Constructive Neural-Network Approach to Modeling Psychological Development

    Science.gov (United States)

    Shultz, Thomas R.

    2012-01-01

    This article reviews a particular computational modeling approach to the study of psychological development--that of constructive neural networks. This approach is applied to a variety of developmental domains and issues, including Piagetian tasks, shift learning, language acquisition, number comparison, habituation of visual attention, concept…

  1. Development of a hybrid system of artificial neural networks and ...

    African Journals Online (AJOL)

    Development of a hybrid system of artificial neural networks and artificial bee colony algorithm for prediction and modeling of customer choice in the market. ... attempted to present a new method for the modeling and prediction of customer choice in the market using the combination of artificial intelligence and data mining.

  2. Synaptic model for spontaneous activity in developing networks

    DEFF Research Database (Denmark)

    Lerchner, Alexander; Rinzel, J.

    2005-01-01

    Spontaneous rhythmic activity occurs in many developing neural networks. The activity in these hyperexcitable networks is comprised of recurring "episodes" consisting of "cycles" of high activity that alternate with "silent phases" with little or no activity. We introduce a new model of synaptic...... dynamics that takes into account that only a fraction of the vesicles stored in a synaptic terminal is readily available for release. We show that our model can reproduce spontaneous rhythmic activity with the same general features as observed in experiments, including a positive correlation between...

  3. Strategies for Power/Energy Saving in Distribution Networks

    Directory of Open Access Journals (Sweden)

    GRIGORAS, G.

    2010-05-01

    Full Text Available The power/energy losses reduction in distribution systems is an important issue during planning and operation, with important technical and economical implications. Thus, the energy losses minimization implies not only the technical improvement of the network, through its renewal with the introduction of the technological innovations in the equipment and circuit components as well as the optimal planning of the design and development of the network, but also requires the use of the methods and software tools to facilitate the operation process. The paper presents a strategy for power/energy saving which replacement of the 6 kV voltage level with 20 kV voltage level in correlation with the extent of using efficient transformers. In this line, different urban distribution networks were analyzed using fuzzy techniques.

  4. Development scheme of the public power transportation network

    International Nuclear Information System (INIS)

    2005-01-01

    Article 14 of the modified law from February 10, 2000 relative to the modernization and development of the electric utility foresees that the development scheme of the public power transportation network is regularly submitted to the approval of the ministry of energy after advice from the energy regulation commission. The development scheme identifies the areas of 'power fragility' with respect to the existing or future constraints susceptible to occur at the short- or medium-term on the French power grid. This document comprises the text of the law 2000-108 from February 10, 2000, and the complete development scheme with its appendixes (regulatory and administrative context relative to network projects, constraints relative to each administrative region). (J.S.)

  5. SU-E-T-163: Thin-Film Organic Photocell (OPV) Properties in MV and KV Beams for Dosimetry Applications.

    Science.gov (United States)

    Ng, S K; Hesser, J; Zhang, H; Gowrisanker, S; Yakushevich, S; Shulhevich, Y; Abkai, C; Wack, L; Zygmanski, P

    2012-06-01

    To characterize dosimetric properties of low-cost thin film organic-based photovoltaic (OPV) cells to kV and MV x-ray beams for their usage as large area dosimeter for QA and patient safety monitoring device. A series of thin film OPV cells of various areas and thicknesses were irradiated with MV beams to evaluate the stability and reproducibility of their response, linearity and sensitivity to absorbed dose. The OPV response to x-rays of various linac energies were also characterized. Furthermore the practical (clinical) sensitivity of the cells was determined using IMRT sweeping gap test generated with various gap sizes. To evaluate their potential usage in the development of low cost kV imaging device, the OPV cells were irradiated with kV beam (60-120 kVp) from a fluoroscopy unit. Photocell response to the absorbed dose was characterized as a function of the organic thin film thickness and size, beam energy and exposure for kV beams as well. In addition, photocell response was determined with and without thin plastic scintillator. Response of the OPV cells to the absorbed dose from kV and MV beams are stable and reproducible. The photocell response was linearly proportional to the size and about slightly decreasing with the thickness of the organic thin film, which agrees with the general performance of the photocells in visible light. The photocell response increases as a linear function of absorbed dose and x-ray energy. The sweeping gap tests performed showed that OPV cells have sufficient practical sensitivity to measured MV x-ray delivery with gap size as small as 1 mm. With proper calibration, the OPV cells could be used for online radiation dose measurement for quality assurance and patient safety purposes. Their response to kV beam show promising potential in development of low cost kV radiation detection devices. © 2012 American Association of Physicists in Medicine.

  6. Towards the systematic development of medical networking technology.

    Science.gov (United States)

    Faust, Oliver; Shetty, Ravindra; Sree, S Vinitha; Acharya, Sripathi; Acharya U, Rajendra; Ng, E Y K; Poo, Chua Kok; Suri, Jasjit

    2011-12-01

    Currently, there is a disparity in the availability of doctors between urban and rural areas of developing countries. Most experienced doctors and specialists, as well as advanced diagnostic technologies, are available in urban areas. People living in rural areas have less or sometimes even no access to affordable healthcare facilities. Increasing the number of doctors and charitable medical hospitals or deploying advanced medical technologies in these areas might not be economically feasible, especially in developing countries. We need to mobilize science and technology to master this complex, large scale problem in an objective, logical, and professional way. This can only be achieved with a collaborative effort where a team of experts works on both technical and non-technical aspects of this health care divide. In this paper we use a systems engineering framework to discuss hospital networks which might be solution for the problem. We argue that with the advancement in communication and networking technologies, economically middle class people and even some rural poor have access to internet and mobile communication systems. Thus, Hospital Digital Networking Technologies (HDNT), such as telemedicine, can be developed to utilize internet, mobile and satellite communication systems to connect primitive rural healthcare centers to well advanced modern urban setups and thereby provide better consultation and diagnostic care to the needy people. This paper describes requirements and limitations of the HDNTs. It also presents the features of telemedicine, the implementation issues and the application of wireless technologies in the field of medical networking.

  7. Developing Visualization Techniques for Semantics-based Information Networks

    Science.gov (United States)

    Keller, Richard M.; Hall, David R.

    2003-01-01

    Information systems incorporating complex network structured information spaces with a semantic underpinning - such as hypermedia networks, semantic networks, topic maps, and concept maps - are being deployed to solve some of NASA s critical information management problems. This paper describes some of the human interaction and navigation problems associated with complex semantic information spaces and describes a set of new visual interface approaches to address these problems. A key strategy is to leverage semantic knowledge represented within these information spaces to construct abstractions and views that will be meaningful to the human user. Human-computer interaction methodologies will guide the development and evaluation of these approaches, which will benefit deployed NASA systems and also apply to information systems based on the emerging Semantic Web.

  8. Development of a wireless radioactive material sensor network

    Energy Technology Data Exchange (ETDEWEB)

    Katsis, Dimosthenis, E-mail: katsisdc@ieee.org [US Army Research Laboratory, Athena Energy Corporation, Adelphi, Bowie, MD (United States); Burns, David; Henriquez, Stanley; Howell, Steve; Litz, Marc [US Army Research Laboratory, Athena Energy Corporation, Adelphi, Bowie, MD (United States)

    2011-10-01

    Our team at the United States Army Research Laboratory (ARL) has designed and developed a low-power, compact, wireless-networked gamma sensor (WGS) array. The WGS system provides high sensitivity gamma photon detection and remote warning for a broad range of radioactive materials. This sensor identifies the presence of a 1 {mu}Ci Cs137 source at a distance of 1.5 m. The networked array of sensors presently operates as a facility and laboratory sensor for the movement of radioactive check sources. Our goal has been to apply this architecture for field security applications by incorporating low-power design with compact packaging. The performance of this radiation measurement network is demonstrated for both detection and location of radioactive material.

  9. Development of the network architecture of the Canadian MSAT system

    Science.gov (United States)

    Davies, N. George; Shoamanesh, Alireza; Leung, Victor C. M.

    1988-05-01

    A description is given of the present concept for the Canadian Mobile Satellite (MSAT) System and the development of the network architecture which will accommodate the planned family of three categories of service: a mobile radio service (MRS), a mobile telephone service (MTS), and a mobile data service (MDS). The MSAT satellite will have cross-strapped L-band and Ku-band transponders to provide communications services between L-band mobile terminals and fixed base stations supporting dispatcher-type MRS, gateway stations supporting MTS interconnections to the public telephone network, data hub stations supporting the MDS, and the network control center. The currently perceived centralized architecture with demand assignment multiple access for the circuit switched MRS, MTS and permanently assigned channels for the packet switched MDS is discussed.

  10. Modelling cheetah relocation success in southern Africa using an iterative Bayesian network development cycle

    CSIR Research Space (South Africa)

    Johnson, S

    2010-02-01

    Full Text Available metapopulations was the focus of a Bayesian Network (BN) modelling workshop in South Africa. Using a new heuristics, Iterative Bayesian Network Development Cycle (IBNDC), described in this paper, several networks were formulated to distinguish between the unique...

  11. Networking and professional development among teachers of Early Childhood Education

    Directory of Open Access Journals (Sweden)

    Rosario Mérida Serrano

    2017-06-01

    Full Text Available This paper evaluates the professional development of 24 teachers involved in the Early Childhood Education-CPD Centre for Teachers-University Network ([blind review]. Collaborative research-action is carried out with teachers and pupils of Early Childhood Education, an adviser from the Continuing Professional Development (CPD Centre for Teachers, researchers, and teacher training undergraduates from the University of [blind review] ([blind review]. Taking a qualitative approach, through interviews, focus groups, and research journals, the benefits obtained by the teachers through their involvement in the [blind review] network are identified: (1 Their colleagues offer them emotional support and provide examples of good practices; (2 The teacher training undergraduates provide technological resources and the possibility of calmly observing what goes on in the classroom; (3 The researchers foster processes of reflection about practice and endorse the validity of the Project Approach; (4 The adviser provides continuing professional development.

  12. Space-based Networking Technology Developments in the Interplanetary Network Directorate Information Technology Program

    Science.gov (United States)

    Clare, Loren; Clement, B.; Gao, J.; Hutcherson, J.; Jennings, E.

    2006-01-01

    Described recent development of communications protocols, services, and associated tools targeted to reduce risk, reduce cost and increase efficiency of IND infrastructure and supported mission operations. Space-based networking technologies developed were: a) Provide differentiated quality of service (QoS) that will give precedence to traffic that users have selected as having the greatest importance and/or time-criticality; b) Improve the total value of information to users through the use of QoS prioritization techniques; c) Increase operational flexibility and improve command-response turnaround; d) Enable new class of networked and collaborative science missions; e) Simplify applications interfaces to communications services; and f) Reduce risk and cost from a common object model and automated scheduling and communications protocols. Technologies are described in three general areas: communications scheduling, middleware, and protocols. Additionally developed simulation environment, which provides comprehensive, quantitative understanding of the technologies performance within overall, evolving architecture, as well as ability to refine & optimize specific components.

  13. The European ALARA network. Development, functioning and main activities

    International Nuclear Information System (INIS)

    Schmitt-Hannig, A.

    2009-01-01

    The new ICRP recommendations (ICRP 103), and in particular the detailed treatment of optimisation in the ICRP Publication 101, define optimisation of protection as a source-related process aimed at keeping the likelihood of incurred exposures, the number of people exposed and the magnitude of their individual doses as low as reasonably achievable, also below constraints, taking into account economic and societal factors. Practical implementation and further development of the ALARA principle has been achieved for many years now by the successful cooperation of experts from different European organisations; first as pioneers by establishing the European ALARA Network and then by enthusiastically supporting the activities of the network itself. This contribution presents the evolution, operation and key activities of the European ALARA Network (EAN) in the last years; the successful cooperation of experts from different professional backgrounds, advocating the ALARA principle in a range of radiation protection areas, and contributing to its further development by trading experience and networking. The interaction between the EAN and international organisations, which support the ALARA principle by including relevant activities in their work programmes, is described. (orig.)

  14. Innovation Network Development Model in Telemedicine: A Change in Participation.

    Science.gov (United States)

    Goodarzi, Maryam; Torabi, Mashallah; Safdari, Reza; Dargahi, Hossein; Naeimi, Sara

    2015-10-01

    This paper introduces a telemedicine innovation network and reports its implementation in Tehran University of Medical Sciences. The required conditions for the development of future projects in the field of telemedicine are also discussed; such projects should be based on the common needs and opportunities in the areas of healthcare, education, and technology. The development of the telemedicine innovation network in Tehran University of Medical Sciences was carried out in two phases: identifying the beneficiaries of telemedicine, and codification of the innovation network memorandum; and brainstorming of three workgroup members, and completion and clustering ideas. The present study employed a qualitative survey by using brain storming method. Thus, the ideas of the innovation network members were gathered, and by using Freeplane software, all of them were clustered and innovation projects were defined. In the services workgroup, 87 and 25 ideas were confirmed in phase 1 and phase 2, respectively. In the education workgroup, 8 new programs in the areas of telemedicine, tele-education and teleconsultation were codified. In the technology workgroup, 101 and 11 ideas were registered in phase 1 and phase 2, respectively. Today, innovation is considered a major infrastructural element of any change or progress. Thus, the successful implementation of a telemedicine project not only needs funding, human resources, and full equipment. It also requires the use of innovation models to cover several different aspects of change and progress. The results of the study can provide a basis for the implementation of future telemedicine projects using new participatory, creative, and innovative models.

  15. Dosimetry in phantom of newborn head for computerized tomography signs with voltages of 80, 100 and 120 KV

    International Nuclear Information System (INIS)

    Oliveira, G.A.P.; Mourão, A.P.

    2017-01-01

    Computed Tomography is the radiodiagnostic method that most contributes to the dose deposition in population. Therefore, the dose reductions used in these tests are very important, especially for pediatric patients who have a life expectancy greater than the rest of the population. This study purpose to compare the doses generated from newborns (NB) with different voltages in a 64-channel multichannel CT equipment of the GE brand. One head phantom in a cylindrical shape made in PMMA were used to newborn patient dimensions. 100 mA.s of charge of the X-ray tube were standardized, alternating the voltages between 80, 100, 120 kV in the axial acquisition. The absorbed dose measurements were performed with a pencil-type ionization chamber positioned within the five apertures in the phantom. The phantom was developed with the cephalic percentile of male NB of 14 and female of 28 days, respectively. The doses obtained in the head phantom of NB were compared with the voltages of 80, 100 and 120 kV. The volumetric dose index, C VOL , generated in the 120 kV protocol was 25.10 mGy, for 100 kV of 19,06 mGy and not for 80 kV 15,81 mGy. The results allow to evaluate that for the generation of images with 120 kV, the dose was 37.0% higher when compared to the voltage of 80 kV. The study shows that the increase in tension in the tomography protocols also makes it possible to increase the dose for the NB patient. (author)

  16. Dosimetry in phantom of newborn head for computerized tomography signs with voltages of 80, 100 and 120 KV

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira, G.A.P.; Mourão, A.P., E-mail: giovanni.paiva@pbh.gov.br, E-mail: apratabhz@gmail.com [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil). Dept. de Engenharia Nuclear

    2017-07-01

    Computed Tomography is the radiodiagnostic method that most contributes to the dose deposition in population. Therefore, the dose reductions used in these tests are very important, especially for pediatric patients who have a life expectancy greater than the rest of the population. This study purpose to compare the doses generated from newborns (NB) with different voltages in a 64-channel multichannel CT equipment of the GE brand. One head phantom in a cylindrical shape made in PMMA were used to newborn patient dimensions. 100 mA.s of charge of the X-ray tube were standardized, alternating the voltages between 80, 100, 120 kV in the axial acquisition. The absorbed dose measurements were performed with a pencil-type ionization chamber positioned within the five apertures in the phantom. The phantom was developed with the cephalic percentile of male NB of 14 and female of 28 days, respectively. The doses obtained in the head phantom of NB were compared with the voltages of 80, 100 and 120 kV. The volumetric dose index, C{sub VOL}, generated in the 120 kV protocol was 25.10 mGy, for 100 kV of 19,06 mGy and not for 80 kV 15,81 mGy. The results allow to evaluate that for the generation of images with 120 kV, the dose was 37.0% higher when compared to the voltage of 80 kV. The study shows that the increase in tension in the tomography protocols also makes it possible to increase the dose for the NB patient. (author)

  17. Factors Affecting Green Residential Building Development: Social Network Analysis

    Directory of Open Access Journals (Sweden)

    Xiaodong Yang

    2018-05-01

    Full Text Available Green residential buildings (GRBs are one of the effective practices of energy saving and emission reduction in the construction industry. However, many real estate developers in China are less willing to develop GRBs, because of the factors affecting green residential building development (GRBD. In order to promote the sustainable development of GRBs in China, this paper, based on the perspective of real estate developers, identifies the influential and critical factors affecting GRBD, using the method of social network analysis (SNA. Firstly, 14 factors affecting GRBD are determined from 64 preliminary factors of three main elements, and the framework is established. Secondly, the relationships between the 14 factors are analyzed by SNA. Finally, four critical factors for GRBD, which are on the local economy development level, development strategy and innovation orientation, developer’s acknowledgement and positioning for GRBD, and experience and ability for GRBD, are identified by the social network centrality test. The findings illustrate the key issues that affect the development of GRBs, and provide references for policy making by the government and strategy formulation by real estate developers.

  18. Differential expression of the Kv1 voltage-gated potassium channel family in the rat nephron.

    Science.gov (United States)

    Carrisoza-Gaytán, Rolando; Salvador, Carolina; Diaz-Bello, Beatriz; Escobar, Laura I

    2014-10-01

    Several potassium (K(+)) channels contribute to maintaining the resting membrane potential of renal epithelial cells. Apart from buffering the cell membrane potential and cell volume, K(+) channels allow sodium reabsorption in the proximal tubule (PT), K(+) recycling and K(+) reabsorption in the thick ascending limb (TAL) and K(+) secretion and K(+) reabsorption in the distal convoluted tubule (DCT), connecting tubule (CNT) and collecting duct. Previously, we identified Kv.1.1, Kv1.3 and Kv1.6 channels in collecting ducts of the rat inner medulla. We also detected intracellular Kv1.3 channel in the acid secretory intercalated cells, which is trafficked to the apical membrane in response to dietary K(+) to function as a secretory K(+) channel. In this work we sought to characterize the expression of all members of the Kv1 family in the rat nephron. mRNA and protein expression were detected for all Kv1 channels. Immunoblots identified differential expression of each Kv1 in the cortex, outer and inner medulla. Immunofluorescence labeling detected Kv1.5 in Bowman´s capsule and endothelial cells and Kv1.7 in podocytes, endothelial cells and macula densa in glomeruli; Kv1.4, Kv1.5 and Kv1.7 in PT; Kv1.2, Kv1.4 and Kv1.6 in TAL; Kv1.1, Kv1.4 and Kv1.6 in DCT and CNT and Kv1.3 in DCT, and all the Kv1 family in the cortical and medullary collecting ducts. Recently, some hereditary renal syndromes have been attributed to mutations in K(+) channels. Our results expand the repertoire of K(+) channels that contribute to K(+) homeostasis to include the Kv1 family.

  19. Inactivation as a new regulatory mechanism for neuronal Kv7 channels

    DEFF Research Database (Denmark)

    Jensen, Henrik Sindal; Grunnet, Morten; Olesen, Søren-Peter

    2007-01-01

    neuronal channels and are important for controlling excitability. Kv7.1 channels have been considered the only Kv7 channels to undergo inactivation upon depolarization. However, here we demonstrate that inactivation is also an intrinsic property of Kv7.4 and Kv7.5 channels, which inactivate to a larger...

  20. The acrylamide (S)-1 differentially affects Kv7 (KCNQ) potassium channels

    DEFF Research Database (Denmark)

    Bentzen, Bo Hjorth; Schmitt, Nicole; Calloe, Kirstine

    2006-01-01

    The family of Kv7 (KCNQ) potassium channels consists of five members. Kv7.2 and 3 are the primary molecular correlates of the M-current, but also Kv7.4 and Kv7.5 display M-current characteristics. M-channel modulators include blockers (e.g., linopirdine) for cognition enhancement and openers (e.g...

  1. 75 FR 55360 - Networking and Information Technology Research and Development (NITRD) Program: Draft NITRD 2010...

    Science.gov (United States)

    2010-09-10

    ... NATIONAL SCIENCE FOUNDATION Networking and Information Technology Research and Development (NITRD... Information Technology Research and Development (NITRD). ACTION: Notice, request for public comment. FOR..., the National Coordination Office for Networking and Information Technology Research and Development...

  2. Services Sector Development and Improving Production Network in ASEAN

    OpenAIRE

    Yose Rizal Damuri

    2014-01-01

    While the importance of services sector in creating value added and employment has been recognized, the role of services as providers of major inputs to production sector are often forgotten and overlooked. This paper stresses the importance of services sector in supporting economic activities in general; the role that has become increasingly more critical in the wake of global production network. It argues that development of the services sector is crucial to supporting an economy’s partic...

  3. The CIRTL Network: A Professional Development Network for Future STEM Faculty

    Science.gov (United States)

    Herbert, B. E.

    2011-12-01

    The Center for the Integration of Research, Teaching, and Learning (CIRTL) is an NSF Center for Learning and Teaching in higher education using the professional development of graduate students and post-doctoral scholars as the leverage point to develop a national STEM faculty committed to implementing and advancing effective teaching practices for diverse student audiences as part of successful professional careers. The goal of CIRTL is to improve the STEM learning of all students at every college and university, and thereby to increase the diversity in STEM fields and the STEM literacy of the nation. The CIRTL network seeks to support change at a number of levels to support its goals: individual, classroom, institutional, and national. To bring about change, which is never easy, the CIRTL network has developed a conceptual model or change model that is thought to support the program objectives. Three central concepts, Teaching-as-Research, Learning Communities, and Learning-through-Diversity, underlie the design of all CIRTL activities. STEM faculty use research methods to systematically and reflectively improve learning outcomes. This work is done within a community of shared learning and discovery, and explicitly recognizes that effective teaching capitalizes on the rich array of experiences, backgrounds, and skills among the students and instructors to enhance the learning of all. This model is being refined and tested through a networked-design experiment, where the model is tested in diverse settings. Established in fall 2006, the CIRTL Network comprises the University of Colorado at Boulder (CU), Howard University, Michigan State University, Texas A&M University, Vanderbilt University, and the University of Wisconsin-Madison. The diversity of these institutions is by design: private/public; large/moderate size; majority-/minority-serving; geographic location. This talk will describe the theoretical constructs and efficacy of Teaching-as Research as a

  4. Big Social Network Data and Sustainable Economic Development

    Directory of Open Access Journals (Sweden)

    Umit Can

    2017-11-01

    Full Text Available New information technologies have led to the rapid and effective growth of social networks. The amount of data produced by social networks has increased the value of the big data concept, which is one of the popular current phenomena. The immediate or unpredictable effects of a wide array of economic activities on large masses and the reactions to them can be measured by using social media platforms and big data methods. Thus, it would be extremely beneficial to analyze the harmful environmental and social impacts that are caused by unsustainable business applications. As social networks and big data are popular realms currently, their efficient use would be an important factor in sustainable economic development. Accurate analysis of people’s consumption habits and economic tendencies would provide significant advantages to companies. Moreover, unknown consumption factors that affect the economic preferences of individuals can be discovered and economic efficiency can be increased. This study shows that the numerous solution opportunities that are provided by social networks and big data have become significant tools in dynamic policy creation by companies and states, in solving problems related to women’s rights, the environment, and health.

  5. Health Promoting Hospitals – Assessing developments in the network

    Directory of Open Access Journals (Sweden)

    Jürgen M. Pelikan

    2007-12-01

    Full Text Available Hospitals are specific organizational settings for health promotion efforts. As health care institutions they are already oriented at health, or better at ill health, but with a rather limited focus on health outcomes for patients. Therefore, the Ottawa Charter explicitly asks for the reorientation of health services. And, hospitals also have considerable health effects for other stakeholder populations. This specific potential and challenge has been taken up by the WHO network of Health Promoting Hospitals (HPH, in the last two decades. Based on available literature the article relates the HPH concept to a more general paradigm of health promoting organizational settings; reconstructs the developmental phases of the international WHO HPH Network; elaborates on its concept development and implementation experiences, and discusses its rather limited investments in evaluation studies and the few assessments from outside. HPH has developed a convincing comprehensive concept by demonstration projects, using systematically action and evaluation research. To a lesser degree, the same holds true for its developments of health promotion policies for selected vulnerable groups and linking HPH to quality methodology. But there is no systematic evaluation of health promotion in and by hospitals, especially for the networks and member hospitals of HPH. Even if much of the relevant evidence for HPH comes and will have to come from more general clinical epidemiological, health promotion, quality, organizational and management research, there is need for specific HPH evaluation research, to better utilize, what can be learned from the social experiment of HPH.

  6. Wearable Device Control Platform Technology for Network Application Development

    Directory of Open Access Journals (Sweden)

    Heejung Kim

    2016-01-01

    Full Text Available Application development platform is the most important environment in IT industry. There are a variety of platforms. Although the native development enables application to optimize, various languages and software development kits need to be acquired according to the device. The coexistence of smart devices and platforms has rendered the native development approach time and cost consuming. Cross-platform development emerged as a response to these issues. These platforms generate applications for multiple devices based on web languages. Nevertheless, development requires additional implementation based on a native language because of the coverage and functions of supported application programming interfaces (APIs. Wearable devices have recently attracted considerable attention. These devices only support Bluetooth-based interdevice communication, thereby making communication and device control impossible beyond a certain range. We propose Network Application Agent (NetApp-Agent in order to overcome issues. NetApp-Agent based on the Cordova is a wearable device control platform for the development of network applications, controls input/output functions of smartphones and wearable/IoT through the Cordova and Native API, and enables device control and information exchange by external users by offering a self-defined API. We confirmed the efficiency of the proposed platform through experiments and a qualitative assessment of its implementation.

  7. Business Collaboration in Food Networks: Incremental Solution Development

    Directory of Open Access Journals (Sweden)

    Harald Sundmaeker

    2014-10-01

    Full Text Available The paper will present an approach for an incremental solution development that is based on the usage of the currently developed Internet based FIspace business collaboration platform. Key element is the clear segmentation of infrastructures that are either internal or external to the collaborating business entity in the food network. On the one hand, the approach enables to differentiate between specific centralised as well as decentralised ways for data storage and hosting of IT based functionalities. The selection of specific dataexchange protocols and data models is facilitated. On the other hand, the supported solution design and subsequent development is focusing on reusable “software Apps” that can be used on their own and are incorporating a clear added value for the business actors. It will be outlined on how to push the development and introduction of Apps that do not require basic changes of the existing infrastructure. The paper will present an example that is based on the development of a set of Apps for the exchange of product quality related information in food networks, specifically addressing fresh fruits and vegetables. It combines workflow support for data exchange from farm to retail as well as to provide quality feedback information to facilitate the business process improvement. Finally, the latest status of theFIspace platform development will be outlined. Key features and potential ways for real users and software developers in using the FIspace platform that is initiated by science and industry will be outlined.

  8. Optimizing the switching time for 400 kV SF6 circuit breakers

    Science.gov (United States)

    Ciulica, D.

    2018-01-01

    This paper presents real-time voltage and current analysis for optimizing the wave switching point of the circuit breaker SF6. Circuit Breaker plays an important role in power systems. It provides protection for equipment in embedded stations in transport networks. SF6 Circuit Breaker is very important equipment in Power Systems, which is used for up to 400 kV due to its excellent performance. The controlled switching is used to eliminate transient modes and electrodynamic and dielectric charges in the network at manual switching of capacitor, shunt reactors and power transformers. These effects reduce the reliability and lifetime of the equipment installed on the network, or may lead to erroneous protection.

  9. AC transmission, with very high voltages and the 750 kV line

    Energy Technology Data Exchange (ETDEWEB)

    Bocker, H

    1964-01-01

    The economic case for adoption of extra-high voltages for transmitting electric power over distances of the order of 1000 km is discussed. Some special technical developments for solving the problems attached to such high voltages are briefly discussed, particularly in the fields of switching and transients suppression. The first 750-kV projects in Canada and Russia are mentioned. Equipment, e.g., bushings, transformers, etc., operating at such voltages are illustrated.

  10. Developing integrated crop knowledge networks to advance candidate gene discovery.

    Science.gov (United States)

    Hassani-Pak, Keywan; Castellote, Martin; Esch, Maria; Hindle, Matthew; Lysenko, Artem; Taubert, Jan; Rawlings, Christopher

    2016-12-01

    The chances of raising crop productivity to enhance global food security would be greatly improved if we had a complete understanding of all the biological mechanisms that underpinned traits such as crop yield, disease resistance or nutrient and water use efficiency. With more crop genomes emerging all the time, we are nearer having the basic information, at the gene-level, to begin assembling crop gene catalogues and using data from other plant species to understand how the genes function and how their interactions govern crop development and physiology. Unfortunately, the task of creating such a complete knowledge base of gene functions, interaction networks and trait biology is technically challenging because the relevant data are dispersed in myriad databases in a variety of data formats with variable quality and coverage. In this paper we present a general approach for building genome-scale knowledge networks that provide a unified representation of heterogeneous but interconnected datasets to enable effective knowledge mining and gene discovery. We describe the datasets and outline the methods, workflows and tools that we have developed for creating and visualising these networks for the major crop species, wheat and barley. We present the global characteristics of such knowledge networks and with an example linking a seed size phenotype to a barley WRKY transcription factor orthologous to TTG2 from Arabidopsis, we illustrate the value of integrated data in biological knowledge discovery. The software we have developed (www.ondex.org) and the knowledge resources (http://knetminer.rothamsted.ac.uk) we have created are all open-source and provide a first step towards systematic and evidence-based gene discovery in order to facilitate crop improvement.

  11. Transcriptional network systems in cartilage development and disease.

    Science.gov (United States)

    Nishimura, Riko; Hata, Kenji; Nakamura, Eriko; Murakami, Tomohiko; Takahata, Yoshifumi

    2018-04-01

    Transcription factors play important roles in the regulation of cartilage development by controlling the expression of chondrogenic genes. Genetic studies have revealed that Sox9/Sox5/Sox6, Runx2/Runx3 and Osterix in particular are essential for the sequential steps of cartilage development. Importantly, these transcription factors form network systems that are also required for appropriate cartilage development. Molecular cloning approaches have largely contributed to the identification of several transcriptional partners for Sox9 and Runx2 during cartilage development. Although the importance of a negative-feedback loop between Indian hedgehog (Ihh) and parathyroid hormone-related protein (PTHrP) in chondrocyte hypertrophy has been well established, recent studies indicate that several transcription factors interact with the Ihh-PTHrP loop and demonstrated that Ihh has multiple functions in the regulation of cartilage development. The most common cartilage disorder, osteoarthritis, has been reported to result from the pathological action of several transcription factors, including Runx2, C/EBPβ and HIF-2α. On the other hand, NFAT family members appear to play roles in the protection of cartilage from osteoarthritis. It is also becoming important to understand the homeostasis and regulation of articular chondrocytes, because they have different cellular and molecular features from chondrocytes of the growth plate. This review summarizes the regulation and roles of transcriptional network systems in cartilage development and their pathological roles in osteoarthritis.

  12. Cyanobacterial Biofuels: Strategies and Developments on Network and Modeling.

    Science.gov (United States)

    Klanchui, Amornpan; Raethong, Nachon; Prommeenate, Peerada; Vongsangnak, Wanwipa; Meechai, Asawin

    Cyanobacteria, the phototrophic microorganisms, have attracted much attention recently as a promising source for environmentally sustainable biofuels production. However, barriers for commercial markets of cyanobacteria-based biofuels concern the economic feasibility. Miscellaneous strategies for improving the production performance of cyanobacteria have thus been developed. Among these, the simple ad hoc strategies resulting in failure to optimize fully cell growth coupled with desired product yield are explored. With the advancement of genomics and systems biology, a new paradigm toward systems metabolic engineering has been recognized. In particular, a genome-scale metabolic network reconstruction and modeling is a crucial systems-based tool for whole-cell-wide investigation and prediction. In this review, the cyanobacterial genome-scale metabolic models, which offer a system-level understanding of cyanobacterial metabolism, are described. The main process of metabolic network reconstruction and modeling of cyanobacteria are summarized. Strategies and developments on genome-scale network and modeling through the systems metabolic engineering approach are advanced and employed for efficient cyanobacterial-based biofuels production.

  13. Development of optical packet and circuit integrated ring network testbed.

    Science.gov (United States)

    Furukawa, Hideaki; Harai, Hiroaki; Miyazawa, Takaya; Shinada, Satoshi; Kawasaki, Wataru; Wada, Naoya

    2011-12-12

    We developed novel integrated optical packet and circuit switch-node equipment. Compared with our previous equipment, a polarization-independent 4 × 4 semiconductor optical amplifier switch subsystem, gain-controlled optical amplifiers, and one 100 Gbps optical packet transponder and seven 10 Gbps optical path transponders with 10 Gigabit Ethernet (10GbE) client-interfaces were newly installed in the present system. The switch and amplifiers can provide more stable operation without equipment adjustments for the frequent polarization-rotations and dynamic packet-rate changes of optical packets. We constructed an optical packet and circuit integrated ring network testbed consisting of two switch nodes for accelerating network development, and we demonstrated 66 km fiber transmission and switching operation of multiplexed 14-wavelength 10 Gbps optical paths and 100 Gbps optical packets encapsulating 10GbE frames. Error-free (frame error rate optical packets of various packet lengths and packet rates, and stable operation of the network testbed was confirmed. In addition, 4K uncompressed video streaming over OPS links was successfully demonstrated. © 2011 Optical Society of America

  14. Optimum Design of Heat Exchangers Networks Part -I: Software Development

    International Nuclear Information System (INIS)

    Gabr, E.M.A.; EI-Temtamy, S.A.; Deriasl, S.F.; Moustafa, H.A.

    2004-01-01

    In this paper, we have developed a computerized framework for Heat Exchanger Network Synthesis (HENS) with optimality conditions of achieving the least operating and capital cost. The framework of HEN design involves the development three-computer programs, which applied sequentially to design an optimum HEN. The first program Automatic Minimum Utilities [AMU] developed for automatic formulation of LP equations, these equations can be solved by the optimization software [LINDO] to predict minimum hot and cold utilities. The second program based on Vertical Heat Transfer Method [VHTM] for predicting minimum overall heat transfer area and defining the optimum δbT m in. The third program [Mod.RESHEX] developed for targeting of heat transfer area and automatic synthesis of HEN. This program represents the modifications and development of RESHEX method to overcome the design defects, which appeared on original RESHEX applications

  15. Development of Shale Gas Supply Chain Network under Market Uncertainties

    Directory of Open Access Journals (Sweden)

    Jorge Chebeir

    2017-02-01

    Full Text Available The increasing demand of energy has turned the shale gas and shale oil into one of the most promising sources of energy in the United States. In this article, a model is proposed to address the long-term planning problem of the shale gas supply chain under uncertain conditions. A two-stage stochastic programming model is proposed to describe and optimize the shale gas supply chain network. Inherent uncertainty in final products’ prices, such as natural gas and natural gas liquids (NGL, is treated through the utilization of a scenario-based method. A binomial option pricing model is utilized to approximate the stochastic process through the generation of scenario trees. The aim of the proposed model is to generate an appropriate and realistic supply chain network configuration as well as scheduling of different operations throughout the planning horizon of a shale gas development project.

  16. Development of a Universal Networked Timer at NSTX

    International Nuclear Information System (INIS)

    Sichta, P.; Dong, J.; Lawson, J.E.; Oliaro, G.; Wertenbaker, J.

    2005-01-01

    A new Timing and Synchronization System component, the Universal Networked Timer (UNT), is under development at the National Spherical Torus Experiment (NSTX). The UNT is a second-generation multifunction timing device that emulates the timing functionality and electrical interfaces originally provided by various CAMAC modules. Using Field Programmable Gate Array (FPGA) technology, each of the UNT's eight channels can be dynamically programmed to emulate a specific CAMAC module type. The timer is compatible with the existing NSTX timing and synchronization system and will also support a (future) clock system with extended performance. To assist system designers and collaborators, software will be written to integrate the UNT with EPICS, MDSplus, and LabVIEW. This paper will describe the timing capabilities, hardware design, programming/software support, and the current status of the Universal Networked Timer at NSTX

  17. An open repositories network development for medical teaching resources.

    Science.gov (United States)

    Soula, Gérard; Darmoni, Stefan; Le Beux, Pierre; Renard, Jean-Marie; Dahamna, Badisse; Fieschi, Marius

    2010-01-01

    The lack of interoperability between repositories of heterogeneous and geographically widespread data is an obstacle to the diffusion, sharing and reutilization of those data. We present the development of an open repositories network taking into account both the syntactic and semantic interoperability of the different repositories and based on international standards in this field. The network is used by the medical community in France for the diffusion and sharing of digital teaching resources. The syntactic interoperability of the repositories is managed using the OAI-PMH protocol for the exchange of metadata describing the resources. Semantic interoperability is based, on one hand, on the LOM standard for the description of resources and on MESH for the indexing of the latter and, on the other hand, on semantic interoperability management designed to optimize compliance with standards and the quality of the metadata.

  18. JAERI 200 kV electron gun with an NEA-GaAs photocathode

    International Nuclear Information System (INIS)

    Nishitani, Tomohiro; Minehara, Eisuke J.; Hajima, Ryoichi; Nagai, Ryoji; Sawamura, Masaru; Nishimori, Nobuyuki; Kikuzawa, Nobuhiro; Yamauchi, Toshihiko

    2004-01-01

    The photocathode DC-gun with high average current, low beam emittance and long operational lifetime is considered to be indispensable for ERL-FEL. We have started the development program of a 200 keV electron gun with the NEA-GaAs photocathode for the first time in JAERI. In order to long an NEA surface lifetime, the JAERI 200 kV electron gun system consists of a 200 kV DC-gun chamber on extreme high vacuum condition and an NEA activation chamber with load-lock system. We report the goal of photocathode DC-gun R and D and the schedule of a developmental program. (author)

  19. Performance of the 10-kV, 5-MA pulsed-power system for the FRX-C compression experiment

    International Nuclear Information System (INIS)

    Rej, D.J.; Waganaar, W.J.

    1991-01-01

    Performance data are presented for the 10-kV, 5-MA, 1.5-MJ pulsed-power system developed for the Los Alamos magnetic fusion facility FRX-C. This system energizes a low-inductance magnet for the high-power, compression heating of compact toroid plasmas. An ignitron-switched, 20-mF, 10-kV, 4-MA capacitor bank is discharged to produce the main compression field, while an inductively-isolated, 10-mF, 10-kV, 1-MA bank generates an initial magnetic field to accept the translated plasma. To date, the complete system has successfully operated for two years and approximately 2000 high-power discharges. Component performance during typical and fault-mode operation is reviewed. 5 refs., 5 figs

  20. Development of a Deterministic Optimization Model for Design of an Integrated Utility and Hydrogen Supply Network

    International Nuclear Information System (INIS)

    Hwangbo, Soonho; Lee, In-Beum; Han, Jeehoon

    2014-01-01

    Lots of networks are constructed in a large scale industrial complex. Each network meet their demands through production or transportation of materials which are needed to companies in a network. Network directly produces materials for satisfying demands in a company or purchase form outside due to demand uncertainty, financial factor, and so on. Especially utility network and hydrogen network are typical and major networks in a large scale industrial complex. Many studies have been done mainly with focusing on minimizing the total cost or optimizing the network structure. But, few research tries to make an integrated network model by connecting utility network and hydrogen network. In this study, deterministic mixed integer linear programming model is developed for integrating utility network and hydrogen network. Steam Methane Reforming process is necessary for combining two networks. After producing hydrogen from Steam-Methane Reforming process whose raw material is steam vents from utility network, produced hydrogen go into hydrogen network and fulfill own needs. Proposed model can suggest optimized case in integrated network model, optimized blueprint, and calculate optimal total cost. The capability of the proposed model is tested by applying it to Yeosu industrial complex in Korea. Yeosu industrial complex has the one of the biggest petrochemical complex and various papers are based in data of Yeosu industrial complex. From a case study, the integrated network model suggests more optimal conclusions compared with previous results obtained by individually researching utility network and hydrogen network

  1. Caltech/USGS Southern California Seismic Network: Recent Developments

    Science.gov (United States)

    Bhadha, R.; Chen, S.; Crummey, J.; Hauksson, E.; Solanki, K.; Thomas, V. I.; Watkins, M.; Yip, R.; Yu, E.; Given, D.; Peats, R.; Schwarz, S.

    2010-12-01

    The SCSN is the modern digital ground motion seismic network in Southern California and performs the following tasks: 1) Operates remote seismic stations and the central data processing systems in Pasadena; 2) Generates and reports real-time products including location, magnitude, ShakeMap, and others; 3) Responds to FEMA, CalEMA, media, and public inquiries about earthquakes; 4) Manages the production, archival, and distribution of waveforms, phase picks, and other data at the SCEDC; 5) Contributes to development and maintenance of the ANSS Quake Monitoring System (AQMS) software to add new features and improve robustness; 6) Supports the deployment of AQMS to other ANSS member regional seismic networks. The public regularly accesses the CISN, SCSN, and SCEDC web pages for up-to-date quake info and more than 230,000 users subscribe to the Electronic Notification System (ENS) which sends rapid notifications via email and cell phones. We distribute our products via Internet (EIDS), email, and paging, to USGS in Reston and Golden, FEMA, CalEMA, local governments, partner members, and other subscribers. We have developed CISN Display and provide ShakeCast for customers who require real-time earthquake information. The SCSN also exchanges waveform, phase pick, and amplitude data in real-time with several other partner networks, including Menlo Park, UCB, UNR, Anza network, the Tsunami Warning Centers, IRIS, and the NEIC. We operate a number of 24/7 on-call rotations to provide quick response to verify seismic events as well as addressing systems and telemetry issues. As part of our goals to improve quality, robustness, and coverage, some of our recent efforts include: 1) Converting the digital stations in the network to Q330 dataloggers; 2) Developing command and control capabilities such as automated mass re-centering; 3) Migration from serial to Ethernet communications; 4) Clustering of data acquisition servers for fail-over to improve data availability; 5) Use of

  2. Control of Resources for Economic Development in Food Networks

    DEFF Research Database (Denmark)

    Brink, Tove

    2010-01-01

    The challenge of economic development in the 21st century is linked to innovation. Enabling innovation contains a wide span from the new idea to learning how to provide value through the new idea and continuing to how to control resources to perform at prime. The focus in this paper is set on how...... to control resources for innovation to add value and economic development. This paper reveals how crossing dynamic composite underlying boundaries can have an impact on control of resources for economic development in food networking SMEs .The analyses in this paper shows the broad and significant impact....... Connections are revealed to have no significant influence on the internal control of resources but a significant direct influence on economic development through value chain activities. Through the analyses in this paper the notion of ‘boundary utility’ is elaborated as the crossing and transformation...

  3. A 120kV IGBT modulator for driving a Pierce electron gun

    International Nuclear Information System (INIS)

    Earley, Lawrence M.; Brown, Richard W.; Carlson, Randolph L.; Ferguson, Patrick; Haynes, William B.; Kirbie, Hugh C.; Russell, Steven J.; Sigler, Floyd E.; Smirnova, Evgenya I.; Wheat, Robert M. Jr.

    2004-01-01

    An IGBT modulator has been developed to drive a 120 kV, 23 A Pierce electron gun. The modulator is capable of producing pulses up to 10 μs in width at repetition rates up to 10Hz with no active reset. The pulse rise time on the electron gun will be approximately 2 μs and the remaining 8 μs of flattop is tuned to have a ripple of less than 1 percent rms. The modulator technology was developed from a previous 50 kV prototype. The modulator consists of six boards, each with one EUPEC IGBT that drives a single common step-up transformer wound on METGLAS 2605SC cores. The six transformer cores share a common bi-filar output secondary winding. The modulator uses a fiber optic trigger system and has a high voltage cable output with an epoxy receptacle on the oil end and a ceramic receptacle on the vacuum end. The 120 kV electron gun was manufactured by MDS Co. and will be used to generate sheet electron beams from the standard pencil beam produced by the Pierce electron gun.

  4. Developing A Large-Scale, Collaborative, Productive Geoscience Education Network

    Science.gov (United States)

    Manduca, C. A.; Bralower, T. J.; Egger, A. E.; Fox, S.; Ledley, T. S.; Macdonald, H.; Mcconnell, D. A.; Mogk, D. W.; Tewksbury, B. J.

    2012-12-01

    Over the past 15 years, the geoscience education community has grown substantially and developed broad and deep capacity for collaboration and dissemination of ideas. While this community is best viewed as emergent from complex interactions among changing educational needs and opportunities, we highlight the role of several large projects in the development of a network within this community. In the 1990s, three NSF projects came together to build a robust web infrastructure to support the production and dissemination of on-line resources: On The Cutting Edge (OTCE), Earth Exploration Toolbook, and Starting Point: Teaching Introductory Geoscience. Along with the contemporaneous Digital Library for Earth System Education, these projects engaged geoscience educators nationwide in exploring professional development experiences that produced lasting on-line resources, collaborative authoring of resources, and models for web-based support for geoscience teaching. As a result, a culture developed in the 2000s in which geoscience educators anticipated that resources for geoscience teaching would be shared broadly and that collaborative authoring would be productive and engaging. By this time, a diverse set of examples demonstrated the power of the web infrastructure in supporting collaboration, dissemination and professional development . Building on this foundation, more recent work has expanded both the size of the network and the scope of its work. Many large research projects initiated collaborations to disseminate resources supporting educational use of their data. Research results from the rapidly expanding geoscience education research community were integrated into the Pedagogies in Action website and OTCE. Projects engaged faculty across the nation in large-scale data collection and educational research. The Climate Literacy and Energy Awareness Network and OTCE engaged community members in reviewing the expanding body of on-line resources. Building Strong

  5. Secure, Mobile, Wireless Network Technology Designed, Developed, and Demonstrated

    Science.gov (United States)

    Ivancic, William D.; Paulsen, Phillip E.

    2004-01-01

    The inability to seamlessly disseminate data securely over a high-integrity, wireless broadband network has been identified as a primary technical barrier to providing an order-of-magnitude increase in aviation capacity and safety. Secure, autonomous communications to and from aircraft will enable advanced, automated, data-intensive air traffic management concepts, increase National Air Space (NAS) capacity, and potentially reduce the overall cost of air travel operations. For the first time ever, secure, mobile, network technology was designed, developed, and demonstrated with state-ofthe- art protocols and applications by a diverse, cooperative Government-industry team led by the NASA Glenn Research Center. This revolutionary technology solution will make fundamentally new airplane system capabilities possible by enabling secure, seamless network connections from platforms in motion (e.g., cars, ships, aircraft, and satellites) to existing terrestrial systems without the need for manual reconfiguration. Called Mobile Router, the new technology autonomously connects and configures networks as they traverse from one operating theater to another. The Mobile Router demonstration aboard the Neah Bay, a U.S. Coast Guard vessel stationed in Cleveland, Ohio, accomplished secure, seamless interoperability of mobile network systems across multiple domains without manual system reconfiguration. The Neah Bay was chosen because of its low cost and communications mission similarity to low-Earth-orbiting satellite platforms. This technology was successfully advanced from technology readiness level (TRL) 2 (concept and/or application formation) to TRL 6 (system model or prototype demonstration in a relevant environment). The secure, seamless interoperability offered by the Mobile Router and encryption device will enable several new, vehicle-specific and systemwide technologies to perform such things as remote, autonomous aircraft performance monitoring and early detection and

  6. Project ECHO: A Telementoring Network Model for Continuing Professional Development.

    Science.gov (United States)

    Arora, Sanjeev; Kalishman, Summers G; Thornton, Karla A; Komaromy, Miriam S; Katzman, Joanna G; Struminger, Bruce B; Rayburn, William F

    2017-01-01

    A major challenge with current systems of CME is the inability to translate the explosive growth in health care knowledge into daily practice. Project ECHO (Extension for Community Healthcare Outcomes) is a telementoring network designed for continuing professional development (CPD) and improving patient outcomes. The purpose of this article was to describe how the model has complied with recommendations from several authoritative reports about redesigning and enhancing CPD. This model links primary care clinicians through a knowledge network with an interprofessional team of specialists from an academic medical center who provide telementoring and ongoing education enabling community clinicians to treat patients with a variety of complex conditions. Knowledge and skills are shared during weekly condition-specific videoconferences. The model exemplifies learning as described in the seven levels of CPD by Moore (participation, satisfaction, learning, competence, performance, patient, and community health). The model is also aligned with recommendations from four national reports intended to redesign knowledge transfer in improving health care. Efforts in learning sessions focus on information that is relevant to practice, focus on evidence, education methodology, tailoring of recommendations to individual needs and community resources, and interprofessionalism. Project ECHO serves as a telementoring network model of CPD that aligns with current best practice recommendations for CME. This transformative initiative has the potential to serve as a leading model for larger scale CPD, nationally and globally, to enhance access to care, improve quality, and reduce cost.

  7. Skeletal muscle Kv7 (KCNQ) channels in myoblast differentiation and proliferation

    International Nuclear Information System (INIS)

    Roura-Ferrer, Meritxell; Sole, Laura; Martinez-Marmol, Ramon; Villalonga, Nuria; Felipe, Antonio

    2008-01-01

    Voltage-dependent K + channels (Kv) are involved in myocyte proliferation and differentiation by triggering changes in membrane potential and regulating cell volume. Since Kv7 channels may participate in these events, the purpose of this study was to investigate whether skeletal muscle Kv7.1 and Kv7.5 were involved during proliferation and myogenesis. Here we report that, while myotube formation did not regulate Kv7 channels, Kv7.5 was up-regulated during cell cycle progression. Although, Kv7.1 mRNA also increased during the G 1 -phase, pharmacological evidence mainly involves Kv7.5 in myoblast growth. Our results indicate that the cell cycle-dependent expression of Kv7.5 is involved in skeletal muscle cell proliferation

  8. Networking for Education for Sustainable Development in Austria: The Austrian ECOLOG-Schools Programme

    Science.gov (United States)

    Rauch, Franz

    2016-01-01

    This case describes networking for education for sustainable development within the Austrian ECOLOG-schools network. The article presents theoretical concepts of networks in education in general, and the organization of the ECOLOG-network in particular. Based upon these foundations, the concept and results of a participatory evaluation study are…

  9. Uncovering changes in university teachers' professional networks during an instructional development program

    NARCIS (Netherlands)

    Van Waes, Sara; Van den Bossche, Piet; Moolenaar, Nienke M.|info:eu-repo/dai/nl/304352802; Stes, Ann; Van Petegem, Peter

    2015-01-01

    This study examined (1) the extent to which university teachers' networks changed while they participated in an instructional development program, (2) which mechanisms supported or constrained network change, and (3) the extent to which value was created through networks. Longitudinal social network

  10. Development of standard logic network for PWR NSSS system design

    International Nuclear Information System (INIS)

    Chung, Moon Kyu; Lee, Byeong Ryeong; Lee, Pan Kwon; Lee, Hae Joon; Park, Joon Won; Song, Tae Gil; Kim, Dong Hui; Choi, Hyeon Ho

    1993-05-01

    The self-reliance of NSSS System Design is required not only the design capability to perform the system design but also the management capability to control the resource and time for the Project effectively. The purpose of this study is to develop the simplified standard Logic Network that is scheduled on the time and resource using the PERT/CPM method. That is mainly focused on Ulchin 3, 4 Project. We prepare the management tool of NSSS System Design project. And we can utilize it as a reference tool for the similar project which are complex and long term in a next project. (Author)

  11. Development of Network Protocol for the Integrated Safety System

    Energy Technology Data Exchange (ETDEWEB)

    Park, S. W.; Baek, J. I.; Lee, S. H.; Park, C. S.; Park, K. H.; Shin, J. M. [Hannam Univ., Daejeon (Korea, Republic of)

    2007-06-15

    Communication devices in the safety system of nuclear power plants are distinguished from those developed for commercial purposes in terms of a strict requirement of safety. The concept of safety covers the determinability, the reliability, and the separation/isolation to prevent the undesirable interactions among devices. The safety also requires that these properties be never proof less. Most of the current commercialized communication products rarely have the safety properties. Moreover, they can be neither verified nor validated to satisfy the safety property of implementation process. This research proposes the novel architecture and protocol of a data communication network for the safety system in nuclear power plants.

  12. Development of Network Protocol for the Integrated Safety System

    International Nuclear Information System (INIS)

    Park, S. W.; Baek, J. I.; Lee, S. H.; Park, C. S.; Park, K. H.; Shin, J. M.

    2007-06-01

    Communication devices in the safety system of nuclear power plants are distinguished from those developed for commercial purposes in terms of a strict requirement of safety. The concept of safety covers the determinability, the reliability, and the separation/isolation to prevent the undesirable interactions among devices. The safety also requires that these properties be never proof less. Most of the current commercialized communication products rarely have the safety properties. Moreover, they can be neither verified nor validated to satisfy the safety property of implementation process. This research proposes the novel architecture and protocol of a data communication network for the safety system in nuclear power plants

  13. European and national network development plan; Europaeischer und nationaler Netzentwicklungsplan

    Energy Technology Data Exchange (ETDEWEB)

    Ringel, Uwe [ONTRAS - VNG Gastransport GmbH, Leipzig (Germany)

    2011-11-15

    Even today, in the energy mix natural gas makes a significant contribution in order to achieve the climate policy goals. Thus, natural gas transmission grids will play a key role in Europe's energy supply. With the possibility of transforming excess wind power to hydrogen or synthetic methane and feeding syngas into the natural gas transmission grid, the natural gas transmission grid receive another challenging role in the future energy mix. However, this requires new approaches to all parties. In particular, consideration on the development of electricity networks in the planning of the future natural gas infrastructure have to be included.

  14. Developing A National Groundwater-Monitoring Network In Korea

    Science.gov (United States)

    Kim, N. J.; Cho, M. J.; Woo, N. C.

    1995-04-01

    Since the 1960's, the groundwater resources of Korea have been developed without a proper regulatory system for monitoring and preservation, resulting in significant source depletion, land subsidence, water contamination, and sea-water intrusion. With the activation of the "Groundwater Law" in June 1994, the government initiated a project to develop a groundwater-monitoring network to describe general groundwater quality, to define its long-term changes, and to identify major factors affecting changes in groundwater quality and yield. In selecting monitoring locations nationwide, criteria considered are 1) spatial distribution, 2) aquifer characteristics of hydrogeologic units, 3) local groundwater flow regime, 4) linkage with surface hydrology observations, 5) site accessibility, and 6) financial situations. A total of 310 sites in 78 small hydrologic basins were selected to compose the monitoring network. Installation of monitoring wells is scheduled to start in 1995 for 15 sites; the remainder are scheduled to be completed by 2001. At each site, a nest of monitoring wells was designed; shallow and deep groundwater will be monitored for water temperature, pH, EC, DO and TDS every month. Water-level fluctuations will also be measured by automatic recorders equipped with pressure transducers. As a next step, the government plans to develop a groundwater-database management system, which could be linked with surface hydrologic data.

  15. Growing up wired: social networking sites and adolescent psychosocial development.

    Science.gov (United States)

    Spies Shapiro, Lauren A; Margolin, Gayla

    2014-03-01

    Since the advent of social networking site (SNS) technologies, adolescents' use of these technologies has expanded and is now a primary way of communicating with and acquiring information about others in their social network. Overall, adolescents and young adults' stated motivations for using SNSs are quite similar to more traditional forms of communication-to stay in touch with friends, make plans, get to know people better, and present oneself to others. We begin with a summary of theories that describe the role of SNSs in adolescents' interpersonal relationships, as well as common methodologies used in this field of research thus far. Then, with the social changes that occur throughout adolescence as a backdrop, we address the ways in which SNSs intersect with key tasks of adolescent psychosocial development, specifically peer affiliation and friendship quality, as well as identity development. Evidence suggests that SNSs differentially relate to adolescents' social connectivity and identity development, with sociability, self-esteem, and nature of SNS feedback as important potential moderators. We synthesize current findings, highlight unanswered questions, and recommend both methodological and theoretical directions for future research.

  16. Ecological network analysis for economic systems: growth and development and implications for sustainable development.

    Science.gov (United States)

    Huang, Jiali; Ulanowicz, Robert E

    2014-01-01

    The quantification of growth and development is an important issue in economics, because these phenomena are closely related to sustainability. We address growth and development from a network perspective in which economic systems are represented as flow networks and analyzed using ecological network analysis (ENA). The Beijing economic system is used as a case study and 11 input-output (I-O) tables for 1985-2010 are converted into currency networks. ENA is used to calculate system-level indices to quantify the growth and development of Beijing. The contributions of each direct flow toward growth and development in 2010 are calculated and their implications for sustainable development are discussed. The results show that during 1985-2010, growth was the main attribute of the Beijing economic system. Although the system grew exponentially, its development fluctuated within only a small range. The results suggest that system ascendency should be increased in order to favor more sustainable development. Ascendency can be augmented in two ways: (1) strengthen those pathways with positive contributions to increasing ascendency and (2) weaken those with negative effects.

  17. Aberration-corrected STEM/TEM imaging at 15 kV

    International Nuclear Information System (INIS)

    Sasaki, Takeo; Sawada, Hidetaka; Hosokawa, Fumio; Sato, Yuta; Suenaga, Kazu

    2014-01-01

    The performance of aberration-corrected (scanning) transmission electron microscopy (S/TEM) at an accelerating voltage of 15 kV was evaluated in a low-voltage microscope equipped with a cold-field emission gun and a higher-order aberration corrector. Aberrations up to the fifth order were corrected by the aberration measurement and auto-correction system using the diffractogram tableau method in TEM and Ronchigram analysis in STEM. TEM observation of nanometer-sized particles demonstrated that aberrations up to an angle of 50 mrad were compensated. A TEM image of Si[110] exhibited lattice fringes with a spacing of 0.192 nm, and the power spectrum of the image showed spots corresponding to distances of 0.111 nm. An annular dark-field STEM image of Si[110] showed lattice fringes of (111) and (22¯0) planes corresponding to lattice distances of 0.314 nm and 0.192 nm, respectively. At an accelerating voltage of 15 kV, the developed low-voltage microscope achieved atomic-resolution imaging with a small chromatic aberration and a large uniform phase. - Highlights: • Aberration-corrected STEM/TEM imaging at 15 kV demonstrated lattice fringes of Si[110] single crystal with a spacing of 0.192 nm. • To achieve this performance at a lower accelerating voltage, uniform phase area over 50 mrad is mandatory in Ronchigram and Diffractogram tableau. • This means a higher-order aberration of six-fold astigmatism should be compensated. • In addition, decreasing the effect of chromatic aberration plays an important role for improving the performance of linear scattering component at 15 kV TEM

  18. Measurements on a FET based 1 MHz, 10 kV pulse generator

    International Nuclear Information System (INIS)

    Wait, G.D.; Barnes, M.J.

    1995-08-01

    A prototype pulser, which incorporates thirty-two 1 kV Field-Effect Transistor (FET) modules, has been built and tested at TRIUMF. The pulser has been developed for application in a scheme for pulsed extraction from the TRIUMF 500 MeV cyclotron. Deflection of the beam will be provided by an electric field between a set of 1 in long deflector plates. The pulser generates a continuous, unipolar, pulse train at a fundamental frequency of approximately 1 MHz and a magnitude of 10 kV. The pulses have 38 ns rise and fall times and are stored on a low-loss coaxial cable which interconnects the pulse generator and the deflector plates. The circuit performance was evaluated with the aid of PSpice in the design stage and confirmed by measurements on the prototype. Temperature measurements have been performed on 1 kV FET modules under DC conditions and compared with temperatures under operating conditions to ensure that switching losses are acceptable. Results of various measurements are presented and compared with simulations

  19. Measurements on a FET based 1 MHz, 10 kV pulse generator

    International Nuclear Information System (INIS)

    Wait, G.D.; Barnes, M.J.

    1995-08-01

    A prototype pulser, which incorporates thirty-two 1 kV Field-Effect Transistor (FET) modules, has been built and tested at TRIUMF. The pulser has been developed for application in a scheme for pulsed extraction from the TRIUMF 500 MeV cyclotron. Deflection of the beam will be provided by an electric field between a set of 1 m long deflector plates. The pulser generates a continuous unipolar, pulse train at a fundamental frequency of approximately 1 MHz and a magnitude of 10 kV. The pulses have 38 ns rise and fall times and are stored on a low-loss coaxial cable which interconnects the pulse generator and the deflector plates. The circuit performance was evaluated with the aid of PSpice in the design stage and confirmed by measurements on the prototype. Temperature measurements have been performed on 1 kV FET modules under DC conditions and compared with temperatures under operating conditions to ensure that switching losses are acceptable. Results of various measurements are presented and compared with simulations. (author)

  20. Implication of novel thiazolo-thiophene derivative (MCD-KV-10) for management of asthma.

    Science.gov (United States)

    Patil, Dhiraj; Dash, Ranjeet Prasad; Thakur, Sandeep Kumar; Pandya, Amit N; Venkatesh, P; Vasu, Kamala K; Nivsarkar, Manish

    2015-04-01

    Asthma is multifaceted disease where many targets contribute towards its development and progression. Among these, adenosine receptor subtypes play a major role. MCD-KV-10, a novel thiazolo-thiophene was designed and evaluated pre-clinically for its implication in management of asthma. This compound showed good affinity and selectivity towards A(2A)/A3 adenosine receptor (AR) subtypes. Furthermore, MCD-KV-10 was evaluated for in vitro lipoxygenase inhibition activity; in vivo mast cell stabilization potential and in vivo anti-asthmatic activity was done in ovalbumin-induced airway inflammation model in guinea pigs. The compound showed good (>57%) inhibition of lipoxygenase enzyme and also effectively protected mast cell degranulation (>63%). The compound showed good anti-asthmatic activity as inferred from the in vivo studies. These results indicate that MCD-KV-10 has an inhibitory effect on airway inflammation. Though, we have identified a potential candidate for management of asthma, further mechanistic studies are needed.

  1. A performance comparison of flat-panel imager-based MV and kV cone-beam CT

    International Nuclear Information System (INIS)

    Groh, B.A.; Siewerdsen, J.H.; Drake, D.G.; Wong, J.W.; Jaffray, D.A.

    2002-01-01

    The use of cone-beam computed tomography (CBCT) has been proposed for guiding the delivery of radiation therapy, and investigators have examined the use of both kilovoltage (kV) and megavoltage (MV) x-ray beams in the development of such CBCT systems. In this paper, the inherent contrast and signal-to-noise ratio (SNR) performance for a variety of existing and hypothetical detectors for CBCT are investigated analytically as a function of imaging dose and object size. Theoretical predictions are compared to the results of experimental investigations employing large-area flat-panel imagers (FPIs) at kV and MV energies. Measurements were performed on two different FPI-based CBCT systems: a bench-top prototype incorporating an FPI and kV x-ray source (100 kVp x rays), and a system incorporating an FPI mounted on the gantry of a medical linear accelerator (6 MV x rays). The SNR in volume reconstructions was measured as a function of dose and found to agree reasonably with theoretical predictions. These results confirm the theoretically predicted advantages of employing kV energy x rays in imaging soft-tissue structures found in the human body. While MV CBCT may provide a valuable means of correcting 3D setup errors and may offer an advantage in terms of simplicity of mechanical integration with a linear accelerator (e.g., implementation in place of a portal imager), kV CBCT offers significant performance advantages in terms of image contrast and SNR per unit dose for visualization of soft-tissue structures. The relatively poor SNR performance at MV energies is primarily a result of the low x-ray quantum efficiencies (∼a few percent or less) that are currently achieved with FPIs at high energies. Furthermore, kV CBCT with an FPI offers the potential of combined volumetric and radiographic/fluoroscopic imaging using the same device

  2. Tyrosine phosphorylation of Kv1.5 is upregulated in intrauterine growth retardation rats with exaggerated pulmonary hypertension

    Directory of Open Access Journals (Sweden)

    L.C. Fu

    2017-09-01

    Full Text Available Intrauterine growth retardation (IUGR is associated with the development of adult-onset diseases, including pulmonary hypertension. However, the underlying mechanism of the early nutritional insult that results in pulmonary vascular dysfunction later in life is not fully understood. Here, we investigated the role of tyrosine phosphorylation of voltage-gated potassium channel 1.5 (Kv1.5 in this prenatal event that results in exaggerated adult vascular dysfunction. A rat model of chronic hypoxia (2 weeks of hypoxia at 12 weeks old following IUGR was used to investigate the physiological and structural effect of intrauterine malnutrition on the pulmonary artery by evaluating pulmonary artery systolic pressure and vascular diameter in male rats. Kv1.5 expression and tyrosine phosphorylation in pulmonary artery smooth muscle cells (PASMCs were determined. We found that IUGR increased mean pulmonary artery pressure and resulted in thicker pulmonary artery smooth muscle layer in 14-week-old rats after 2 weeks of hypoxia, while no difference was observed in normoxia groups. In the PASMCs of IUGR-hypoxia rats, Kv1.5 mRNA and protein expression decreased while that of tyrosine-phosphorylated Kv1.5 significantly increased. These results demonstrate that IUGR leads to exaggerated chronic hypoxia pulmonary arterial hypertension (CH-PAH in association with decreased Kv1.5 expression in PASMCs. This phenomenon may be mediated by increased tyrosine phosphorylation of Kv1.5 in PASMCs and it provides new insight into the prevention and treatment of IUGR-related CH-PAH.

  3. Developing and Testing SpaceWire Devices and Networks

    Science.gov (United States)

    Parkes, Steve; Mills, Stuart

    2014-08-01

    SpaceWire is a data-handling network for use on-board spacecraft, which connects together instruments, mass- memory, processors, downlink telemetry, and other on- board sub-systems [1]. SpaceWire is simple to implement and has some specific characteristics that help it support data-handling applications in space: high-speed, low-power, simplicity, relatively low implementation cost, and architectural flexibility making it ideal for many space missions. SpaceWire provides high-speed (2 Mbits/s to 200 Mbits/s), bi- directional, full-duplex data-links, which connect together SpaceWire enabled equipment. Data-handling networks can be built to suit particular applications using point-to-point data-links and routing switches.Since the SpaceWire standard was published in January 2003, it has been adopted by ESA, NASA, JAXA and RosCosmos for many missions and is being widely used on scientific, Earth observation, commercial and other spacecraft. High-profile missions using SpaceWire include: Gaia, ExoMars rover, Bepi- Colombo, James Webb Space Telescope, GOES-R, Lunar Reconnaissance Orbiter and Astro-H.The development and testing of the SpaceWire links and networks used on these and many other spacecraft currently under development, requires a comprehensive array of test equipment. In this paper the requirements for test equipment fulfilling key test functions are outlined and then equipment that meets these requirements is described. Finally the all-important software that operates with the test equipment is introduced.

  4. An engineering design network for SSC detector development

    International Nuclear Information System (INIS)

    DiGiacomo, N.J.

    1990-01-01

    The detector systems that are being proposed to exploit the capabilities of the SSC are of a scale and scope that will make them among the most complex devices ever built. To successfully design and build these systems over the next decade, the authors must make use of integrated state of the art computer aided engineering and design (CAE/CAD) tools that have been developed and employed in industry. The challenge is to made these tools and associated engineering resources available to the spectrum of institutions - large and small universities, industries and national labs - involved in SSC detector development in such a way that each may contribute and participate in the most effective manner. The authors believe that powerful workstations running sophisticated modeling, analysis and simulation software, linked by high speed data networks and governed by modern configuration management methods offer the ideal means of arriving at the optimum detector configuration for physics at the SSC

  5. MicroRNA-301a mediated regulation of Kv4.2 in diabetes: identification of key modulators.

    Directory of Open Access Journals (Sweden)

    Siva K Panguluri

    Full Text Available Diabetes is a metabolic disorder that ultimately results in major pathophysiological complications in the cardiovascular system. Diabetics are predisposed to higher incidences of sudden cardiac deaths (SCD. Several studies have associated diabetes as a major underlying risk for heart diseases and its complications. The diabetic heart undergoes remodeling to cope up with the underlying changes, however ultimately fails. In the present study we investigated the changes associated with a key ion channel and transcriptional factors in a diabetic heart model. In the mouse db/db model, we identified key transcriptional regulators and mediators that play important roles in the regulation of ion channel expression. Voltage-gated potassium channel (Kv4.2 is modulated in diabetes and is down regulated. We hypothesized that Kv4.2 expression is altered by potassium channel interacting protein-2 (KChIP2 which is regulated upstream by NFkB and miR-301a. We utilized qRT-PCR analysis and identified the genes that are affected in diabetes in a regional specific manner in the heart. At protein level we identified and validated differential expression of Kv4.2 and KChIP2 along with NFkB in both ventricles of diabetic hearts. In addition, we identified up-regulation of miR-301a in diabetic ventricles. We utilized loss and gain of function approaches to identify and validate the role of miR-301a in regulating Kv4.2. Based on in vivo and in vitro studies we conclude that miR-301a may be a central regulator for the expression of Kv4.2 in diabetes. This miR-301 mediated regulation of Kv4.2 is independent of NFkB and Irx5 and modulates Kv4.2 by direct binding on Kv4.2 3'untranslated region (3'-UTR. Therefore targeting miR-301a may offer new potential for developing therapeutic approaches.

  6. A survey on social networks to determine requirements for Learning Networks for professional development of university staff

    NARCIS (Netherlands)

    Brouns, Francis; Berlanga, Adriana; Fetter, Sibren; Bitter-Rijpkema, Marlies; Van Bruggen, Jan; Sloep, Peter

    2009-01-01

    Brouns, F., Berlanga, A. J., Fetter, S., Bitter-Rijpkema, M. E., Van Bruggen, J. M., & Sloep, P. B. (2011). A survey on social networks to determine requirements for Learning Networks for professional development of university staff. International Journal of Web Based Communities, 7(3), 298-311.

  7. Measurement of the Magnetic Fields from High-Voltage (230 kV Substations in Tehran and Assessment of Their Effects

    Directory of Open Access Journals (Sweden)

    Mahdieh Sharifi Fard

    2010-06-01

    Full Text Available Introduction: Recent industrial developments in human societies have caused rapid advancements in technologies of production and distribution of electricity, which in turn result in enhancement of power networks and utilization of high voltages. These networks and the high voltages in transfer lines cause the exposure to electric and magnetic fields. In this study, the situation regarding the magnetic fields from high-voltage (230 kV substations in Tehran was investigated. Material and Methods: In this study, 8 high-voltage (230 kV substations were selected (Shous, Shahid Firouzi, Ozgol, Kan, Tehranpars, Azadegan, Ghorkhane and Besat substations. The premises of each substation was divided into some stations and measurements were done in each one. Measurements were done according to the IEEE std 644-1994 Standard in a way that the device, specifically its probe, was kept at a height of 1 meter above the ground surface. Then, we tried to examine the probable effects of exposure to magnetic fields through the Essex questionnaire, with Cronbach coefficient of 94%, completed by the employees of the substations. These questionnaires were completed by substation operators as an exposed group (36 persons and the employees of the office section of the Tehran regional electric company as a witness group (32 persons. Results: The measured density in none of the stations exceeded the standard limits of the International Commission on Non-Ionizing Radiation Protection. With regard to the questionnaire results about mental and neurological, cardiac and respiratory, and gastrointestinal and auditory disorders, we observed significant differences between witness and exposed groups, however, regarding skin allergies, there was no significant difference. Conclusion: Among all control rooms, the highest measured magnetic field was 6.9 mG in the Ozgol Substation Control Room and the lowest was 2 mG in the post of Shahid Firouzi. The control room of Ozgol

  8. Development of Light Powered Sensor Networks for Thermal Comfort Measurement

    Directory of Open Access Journals (Sweden)

    Dasheng Lee

    2008-10-01

    Full Text Available Recent technological advances in wireless communications have enabled easy installation of sensor networks with air conditioning equipment control applications. However, the sensor node power supply, through either power lines or battery power, still presents obstacles to the distribution of the sensing systems. In this study, a novel sensor network, powered by the artificial light, was constructed to achieve wireless power transfer and wireless data communications for thermal comfort measurements. The sensing node integrates an IC-based temperature sensor, a radiation thermometer, a relative humidity sensor, a micro machined flow sensor and a microprocessor for predicting mean vote (PMV calculation. The 935 MHz band RF module was employed for the wireless data communication with a specific protocol based on a special energy beacon enabled mode capable of achieving zero power consumption during the inactive periods of the nodes. A 5W spotlight, with a dual axis tilt platform, can power the distributed nodes over a distance of up to 5 meters. A special algorithm, the maximum entropy method, was developed to estimate the sensing quantity of climate parameters if the communication module did not receive any response from the distributed nodes within a certain time limit. The light-powered sensor networks were able to gather indoor comfort-sensing index levels in good agreement with the comfort-sensing vote (CSV preferred by a human being and the experimental results within the environment suggested that the sensing system could be used in air conditioning systems to implement a comfort-optimal control strategy.

  9. A new approach in development of data flow control and investigation system for computer networks

    International Nuclear Information System (INIS)

    Frolov, I.; Vaguine, A.; Silin, A.

    1992-01-01

    This paper describes a new approach in development of data flow control and investigation system for computer networks. This approach was developed and applied in the Moscow Radiotechnical Institute for control and investigations of Institute computer network. It allowed us to solve our network current problems successfully. Description of our approach is represented below along with the most interesting results of our work. (author)

  10. Applying Fuzzy Artificial Neural Network OSPF to develop Smart ...

    African Journals Online (AJOL)

    pc

    2018-03-05

    Mar 5, 2018 ... Fuzzy Artificial Neural Network to create Smart Routing. Protocol Algorithm. ... manufactured mental aptitude strategy. The capacity to study .... Based Energy Efficiency in Wireless Sensor Networks: A Survey",. International ...

  11. Oscillations, networks, and their development: MEG connectivity changes with age.

    Science.gov (United States)

    Schäfer, Carmen B; Morgan, Benjamin R; Ye, Annette X; Taylor, Margot J; Doesburg, Sam M

    2014-10-01

    Magnetoencephalographic (MEG) investigations of inter-regional amplitude correlations have yielded new insights into the organization and neurophysiology of resting-state networks (RSNs) first identified using fMRI. Inter-regional MEG amplitude correlations in adult RSNs have been shown to be most prominent in alpha and beta frequency ranges and to express strong congruence with RSN topologies found using fMRI. Despite such advances, little is known about how oscillatory connectivity in RSNs develops throughout childhood and adolescence. This study used a novel fMRI-guided MEG approach to investigate the maturation of resting-state amplitude correlations in physiologically relevant frequency ranges within and among six RSNs in 59 participants, aged 6-34 years. We report age-related increases in inter-regional amplitude correlations that were largest in alpha and beta frequency bands. In contrast to fMRI reports, these changes were observed both within and between the various RSNs analyzed. Our results provide the first evidence of developmental changes in spontaneous neurophysiological connectivity in source-resolved RSNs, which indicate increasing integration within and among intrinsic functional brain networks throughout childhood, adolescence, and early adulthood. Copyright © 2014 Wiley Periodicals, Inc.

  12. Social Media for Networking, Professional Development, and Patient Engagement.

    Science.gov (United States)

    Markham, Merry Jennifer; Gentile, Danielle; Graham, David L

    2017-01-01

    Social media has become an established method of communication, and many physicians are finding these interactive tools and platforms to be useful for both personal and professional use. Risks of social media, or barriers to its use, include perceived lack of time, privacy concerns, and the risk of damage to one's reputation by unprofessional behavior. Of the social media platforms, Twitter has become favored by physicians and other health care professionals. Although one of the most obvious uses of social media is for rapid dissemination and receipt of information, oncologists are finding that social media is important for networking through blogs, Facebook, and Twitter. These platforms also have potential for providing opportunities for professional development, such as finding collaborators through networking, participation in Twitter journal clubs, and participating in online case-based tumor boards. Social media can also be used for patient engagement, such as through participation in tweet chats. There is emerging data that patient engagement through these platforms may lead to improvement in some health-related outcomes; however, data are sparse for oncology-specific outcomes. Efforts are underway to determine how to assess how social media engagement impacts health outcomes in oncology patients.

  13. Kv1 channels and neural processing in vestibular calyx afferents

    Directory of Open Access Journals (Sweden)

    Frances L Meredith

    2015-06-01

    Full Text Available Potassium-selective ion channels are important for accurate transmission of signals from auditory and vestibular sensory end organs to their targets in the central nervous system. During different gravity conditions, astronauts experience altered input signals from the peripheral vestibular system resulting in sensorimotor dysfunction. Adaptation to altered sensory input occurs, but it is not explicitly known whether this involves synaptic modifications within the vestibular epithelia. Future investigations of such potential plasticity require a better understanding of the electrophysiological mechanisms underlying the known heterogeneity of afferent discharge under normal conditions. This study advances this understanding by examining the role of the Kv1 potassium channel family in mediating action potentials in specialized vestibular afferent calyx endings in the gerbil crista and utricle. Pharmacological agents selective for different sub-types of Kv1 channels were tested on membrane responses in whole cell recordings in the crista. Kv1 channels sensitive to α-dendrotoxin and dendrotoxin-K were found to prevail in the central regions, whereas K+ channels sensitive to margatoxin, which blocks Kv1.3 and 1.6 channels, were more prominent in peripheral regions. Margatoxin-sensitive currents showed voltage-dependent inactivation. Dendrotoxin-sensitive currents showed no inactivation and dampened excitability in calyces in central neuroepithelial regions. The differential distribution of Kv1 potassium channels in vestibular afferents supports their importance in accurately relaying gravitational and head movement signals through specialized lines to the central nervous system. Pharmacological modulation of specific groups of K+ channels could help alleviate vestibular dysfunction on earth and in space.

  14. Kv1 channels and neural processing in vestibular calyx afferents.

    Science.gov (United States)

    Meredith, Frances L; Kirk, Matthew E; Rennie, Katherine J

    2015-01-01

    Potassium-selective ion channels are important for accurate transmission of signals from auditory and vestibular sensory end organs to their targets in the central nervous system. During different gravity conditions, astronauts experience altered input signals from the peripheral vestibular system resulting in sensorimotor dysfunction. Adaptation to altered sensory input occurs, but it is not explicitly known whether this involves synaptic modifications within the vestibular epithelia. Future investigations of such potential plasticity require a better understanding of the electrophysiological mechanisms underlying the known heterogeneity of afferent discharge under normal conditions. This study advances this understanding by examining the role of the Kv1 potassium channel family in mediating action potentials in specialized vestibular afferent calyx endings in the gerbil crista and utricle. Pharmacological agents selective for different sub-types of Kv1 channels were tested on membrane responses in whole cell recordings in the crista. Kv1 channels sensitive to α-dendrotoxin and dendrotoxin-K were found to prevail in the central regions, whereas K(+) channels sensitive to margatoxin, which blocks Kv1.3 and 1.6 channels, were more prominent in peripheral regions. Margatoxin-sensitive currents showed voltage-dependent inactivation. Dendrotoxin-sensitive currents showed no inactivation and dampened excitability in calyces in central neuroepithelial regions. The differential distribution of Kv1 potassium channels in vestibular afferents supports their importance in accurately relaying gravitational and head movement signals through specialized lines to the central nervous system. Pharmacological modulation of specific groups of K(+) channels could help alleviate vestibular dysfunction on earth and in space.

  15. Developing a network-level structural capacity index for structural evaluation of pavements.

    Science.gov (United States)

    2013-03-01

    The objective of this project was to develop a structural index for use in network-level pavement evaluation to facilitate : the inclusion of the pavements structural condition in pavement management applications. The primary goal of network-level...

  16. The Networking and Information Technology Research and Development NITRD Program 2012 Strategic Plan

    Data.gov (United States)

    Networking and Information Technology Research and Development, Executive Office of the President — Information technology IT computers, wired and wireless digital networks, electronic data and information, IT devices and systems, and software applications?today...

  17. Simulation and optimization of Corona Rings for 300 kV, 120 kHz RF transformer for 3 MeV, 30 kW DC accelerator

    International Nuclear Information System (INIS)

    Das, Swati H.; Dewangan, S.; Sharma, D.K.

    2015-01-01

    The 3 MeV, 30 kW Industrial DC Electron Beam Accelerator with a terminal voltage of 3 MV is designed, developed and housed inside the Electron Beam Centre (EBC) building at Kharghar, Navi Mumbai. The accelerator requires an input voltage of 150 kV-0-150 kV at 120 kHz which is generated by tuned air-core step- up toroidal transformer. The Transformer is rated for 6 kV-0-6 kV primary and 150 kV-0-150 kV secondary at 120 kHz working at 6 kg/cm''2 SF 6 gas environment. Secondary is wound over the perforated insulator former, To limit the electric stress to 5-7 kV/cm on the insulator surface and 120 kV/cm in SF 6 , transformer was simulated in CST EM studio for electric field analysis. Parametric simulations were done to optimize the dimensions and design of corona rings at the High voltage terminals. Simulation results are described in this paper briefly. (author)

  18. Construction and 60 kV tests of the prototype pulser for the LHC injection kicker system

    CERN Document Server

    Barnes, M J; Carlier, E; Ducimetière, L; Schröder, G; Vossenberg, Eugène B

    1999-01-01

    The European Laboratory for Particle Physics (CERN) is constructing the Large Hadron Collider (LHC). Two counter-rotating proton beams will be injected into the LHC at an energy of 450 GeV by two kicker magnet systems, producing magnetic field pulses of approximately 900 ns rise time and 6.6 mu s flat top duration with a ripple of less than +or-0.5Both injection systems are composed of 4 travelling wave kicker magnets of 2.17 m length each, powered by pulse forming networks (PFNs). To achieve the high-required kick strength of 1.2 Tm, for a compact and cost efficient design, a characteristic impedance of 5 Ohms has been chosen. The design strategy for the magnets and generators has been defined after detailed analysis of existing systems. The electrical circuit has been optimised using the circuit analysis software PSpice. Most known parasitics have been modelled. A prototype PFN has been constructed at CERN and successfully tested at 60 kV. A calibration procedure has been developed and utilised for obtainin...

  19. A value network development model and implications for innovation and production network management

    NARCIS (Netherlands)

    Vermeulen, B.; Kok, de A.G.

    2013-01-01

    In managing their value network, firms have to balance current and future value concerns and own and network partners’ concerns. Firms generate immediate value through manufacturing and selling the current generation of products together with other firms in its production network and generate future

  20. Beam Profile Measurement of 300 kV Ion Source Test Stand for 1 MV Electrostatic Accelerator

    International Nuclear Information System (INIS)

    Park, Sae-Hoon; Kim, Yu-Seok; Kim, Dae-Il; Kwon, Hyeok-Jung; Cho, Yong-Sub

    2015-01-01

    In this paper, RF ion source, test stand of the ion source and its test results are presented. Beam profile was measured at the downstream from the accelerating tube and at the beam dump by using BPM and wire scanner. The RF ion source of the test stand is verified by measuring the total beam current with a faraday cup in the chamber. The KOMAC (KOrea Multi-purpose Accelerator Complex) has been developing a 300 kV ion source test stand for a 1 MV electrostatic accelerator. An ion source and accelerating tube will be installed in a high pressure vessel. The ion source in a high pressure vessel requires high reliability. To confirm the stable operation of the ion source, a test stand was proposed and developed. The ion source will be tested at the test stand to verify its long-term operation conditions. The test stand consists of a 300 kV high voltage terminal, a battery for the ion source power, a 60 Hz inverter, a 200 MHz RF power, a 5 kV extraction power supply, a 300 kV accelerating tube, and a vacuum system. The beam profile monitor was installed at the downstream from the accelerating tube. Wire scanner and faraday-cup was installed at the end of the chamber

  1. Beam Profile Measurement of 300 kV Ion Source Test Stand for 1 MV Electrostatic Accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Park, Sae-Hoon; Kim, Yu-Seok [Dongguk University, Gyeonju (Korea, Republic of); Kim, Dae-Il; Kwon, Hyeok-Jung; Cho, Yong-Sub [Korea Multipurpose Accelerator Complex, Gyeongju (Korea, Republic of)

    2015-10-15

    In this paper, RF ion source, test stand of the ion source and its test results are presented. Beam profile was measured at the downstream from the accelerating tube and at the beam dump by using BPM and wire scanner. The RF ion source of the test stand is verified by measuring the total beam current with a faraday cup in the chamber. The KOMAC (KOrea Multi-purpose Accelerator Complex) has been developing a 300 kV ion source test stand for a 1 MV electrostatic accelerator. An ion source and accelerating tube will be installed in a high pressure vessel. The ion source in a high pressure vessel requires high reliability. To confirm the stable operation of the ion source, a test stand was proposed and developed. The ion source will be tested at the test stand to verify its long-term operation conditions. The test stand consists of a 300 kV high voltage terminal, a battery for the ion source power, a 60 Hz inverter, a 200 MHz RF power, a 5 kV extraction power supply, a 300 kV accelerating tube, and a vacuum system. The beam profile monitor was installed at the downstream from the accelerating tube. Wire scanner and faraday-cup was installed at the end of the chamber.

  2. Development of Active External Network Topology Module for Floodlight SDN Controller

    Directory of Open Access Journals (Sweden)

    A. A. Noskov

    2015-01-01

    Full Text Available Traditional network architecture is inflexible and complicated. This observation has led to a paradigm shift towards software-defined networking (SDN, where network management level is separated from data forwarding level. This change was made possible by control plane transfer from the switching equipment to software modules that run on a dedicated server, called the controller (or network operating system, or network applications, that work with this controller. Methods of representation, storage and communication interfaces with network topology elements are the most important aspects of network operating systems available to SDN user because performance of some key controller modules is heavily dependent on internal representation of the network topology. Notably, firewall and routing modules are examples of such modules. This article describes the methods used for presentation and storage of network topologies, as well as interface to the corresponding Floodlight modules. An alternative algorithm has been suggested and developed for message exchange conveying network topology alterations between the controller and network applications. Proposed algorithm makes implementation of module alerting based on subscription to the relevant events. API for interaction between controller and network applications has been developed. This algorithm and API formed the base for Topology Tracker module capable to inform network applications about the changes that had occurred in the network topology and also stores compact representation of the network to speed up the interaction process.

  3. Development of a Software Based Firewall System for Computer Network Traffic Control

    Directory of Open Access Journals (Sweden)

    Ikhajamgbe OYAKHILOME

    2009-12-01

    Full Text Available The connection of an internal network to an external network such as Internet has made it vulnerable to attacks. One class of network attack is unauthorized penetration into network due to the openness of networks. It is possible for hackers to sum access to an internal network, this pose great danger to the network and network resources. Our objective and major concern of network design was to build a secured network, based on software firewall that ensured the integrity and confidentiality of information on the network. We studied several mechanisms to achieve this; one of such mechanism is the implementation of firewall system as a network defence. Our developed firewall has the ability to determine which network traffic should be allowed in or out of the network. Part of our studied work was also channelled towards a comprehensive study of hardware firewall security system with the aim of developing this software based firewall system. Our software firewall goes a long way in protecting an internal network from external unauthorized traffic penetration. We included an anti virus software which is lacking in most firewalls.

  4. Survey of magnetic fields near BPA 230-kV and 500-kV transmission lines

    International Nuclear Information System (INIS)

    Perrin, N.; Aggarwal, R.P.

    1991-01-01

    The purpose of this study was to characterize typical levels and variability of 60Hz magnetic fields at the centerline and edge of right-of-way of Bonneville Power Administration (BPA) 230-kV and 500-kV transmission lines. This was accomplished by taking magnetic field measurements at over 800 spans in Oregon and Washington. The spans were sampled using a stratified random sampling procedure with region (East vs. West), voltage (230-kV vs 500-kV), and circuit configuration as strata. There were five different circuit configuration groups for each region/voltage category requiring a total of 200 strata. Magnetic field measurements were taken at 13 locations under each span using an EMDEX-C as a survey meter. Additional information recorded for each span included conductor height (at 10 locations), right-of-way width, longitudinal and lateral slope, time of day, vegetation, terrain, weather conditions, temperature, wind speed, span length and presence of other lines in the corridor. 9 refs., 17 figs., 26 tabs

  5. KCNE4 is an inhibitory subunit to Kv1.1 and Kv1.3 potassium channels

    DEFF Research Database (Denmark)

    Grunnet, Morten; Rasmussen, Hannne B; Hay-Schmidt, Anders

    2003-01-01

    is detected in the heart and in five different parts of the brain. Having the broad distribution of Kv1 channels in mind, the demonstrated inhibitory property of KCNE4-subunits could locally and/or transiently have a dramatic influence on cellular excitability and on setting resting membrane potentials....

  6. Development of Network-type Archaeological Investigation System

    Science.gov (United States)

    Chiba, F.; Yokokoyama, S.; Kaneda, A.; Konno, K.

    2015-08-01

    The Great East Japan Earthquake on March 11, 2011 is said to be a once-in-1000-year catastrophic quake. The Tsunami triggered by the earthquake destroyed broad coastal areas in northeast Japan. As recovery from the earthquake proceeds, the demand for new road construction, housing hill development, and residential construction is rapidly increasing. Culture plays a critical role in the district's recovery. For that reason, before development, cultural properties in the corresponding districts must be urgently investigated. This is a must, although balancing cultural recovery with rapid economic recovery is no easy task. With this in mind, we have developed a new system focusing on speedy archaeological investigation and adequate documentation. The authors reexamined the existing investigation process to categorize tasks into two types: those that must be done only at archaeological sites (site A) and ones available at other places (site B). We then formulated a scheme where the tasks on both sites are performed simultaneously in parallel over the network. Experiments are ongoing. This presentation reports the process and issues of our research and development.

  7. Development of a cyber security risk model using Bayesian networks

    International Nuclear Information System (INIS)

    Shin, Jinsoo; Son, Hanseong; Khalil ur, Rahman; Heo, Gyunyoung

    2015-01-01

    Cyber security is an emerging safety issue in the nuclear industry, especially in the instrumentation and control (I and C) field. To address the cyber security issue systematically, a model that can be used for cyber security evaluation is required. In this work, a cyber security risk model based on a Bayesian network is suggested for evaluating cyber security for nuclear facilities in an integrated manner. The suggested model enables the evaluation of both the procedural and technical aspects of cyber security, which are related to compliance with regulatory guides and system architectures, respectively. The activity-quality analysis model was developed to evaluate how well people and/or organizations comply with the regulatory guidance associated with cyber security. The architecture analysis model was created to evaluate vulnerabilities and mitigation measures with respect to their effect on cyber security. The two models are integrated into a single model, which is called the cyber security risk model, so that cyber security can be evaluated from procedural and technical viewpoints at the same time. The model was applied to evaluate the cyber security risk of the reactor protection system (RPS) of a research reactor and to demonstrate its usefulness and feasibility. - Highlights: • We developed the cyber security risk model can be find the weak point of cyber security integrated two cyber analysis models by using Bayesian Network. • One is the activity-quality model signifies how people and/or organization comply with the cyber security regulatory guide. • Other is the architecture model represents the probability of cyber-attack on RPS architecture. • The cyber security risk model can provide evidence that is able to determine the key element for cyber security for RPS of a research reactor

  8. Prairie Monitoring Protocol Development: North Coast and Cascades Network

    Science.gov (United States)

    McCoy, Allen; Dalby, Craig

    2009-01-01

    The purpose of the project was to conduct research that will guide development of a standard approach to monitoring several components of prairies within the North Coast and Cascades Network (NCCN) parks. Prairies are an important element of the natural environment at many parks, including San Juan Island National Historical Park (NHP) and Ebey's Landing National Historical Reserve (NHR). Forests have been encroaching on these prairies for many years, and so monitoring of the prairies is an important resource issue. This project specifically focused on San Juan Island NHP. Prairies at Ebey's Landing NHR will be monitored in the future, but that park was not mapped as part of this prototype project. In the interest of efficiency, the Network decided to investigate two main issues before launching a full protocol development effort: (1) the imagery requirements for monitoring prairie components, and (2) the effectiveness of software to assist in extracting features from the imagery. Several components of prairie monitoring were initially identified as being easily tracked using aerial imagery. These components included prairie/forest edge, broad prairie composition (for example, shrubs, scattered trees), and internal exclusions (for example, shrubs, bare ground). In addition, we believed that it might be possible to distinguish different grasses in the prairies if the imagery were of high enough resolution. Although the areas in question at San Juan Island NHP are small enough that mapping on the ground with GPS (Global Positioning System) would be feasible, other applications could benefit from aerial image acquisition on a regular, recurring basis and thereby make the investment in aerial imagery worthwhile. The additional expense of orthorectifying the imagery also was determined to be cost-effective.

  9. Development of cognitive and affective control networks and decision making.

    Science.gov (United States)

    Kar, Bhoomika R; Vijay, Nivita; Mishra, Shreyasi

    2013-01-01

    Cognitive control and decision making are two important research areas in the realm of higher-order cognition. Control processes such as interference control and monitoring in cognitive and affective contexts have been found to influence the process of decision making. Development of control processes follows a gradual growth pattern associated with the prolonged maturation of underlying neural circuits including the lateral prefrontal cortex, anterior cingulate, and the medial prefrontal cortex. These circuits are also involved in the control of processes that influences decision making, particularly with respect to choice behavior. Developmental studies on affective control have shown distinct patterns of brain activity with adolescents showing greater activation of amygdala whereas adults showing greater activity in ventral prefrontal cortex. Conflict detection, monitoring, and adaptation involve anticipation and subsequent performance adjustments which are also critical to complex decision making. We discuss the gradual developmental patterns observed in two of our studies on conflict monitoring and adaptation in affective and nonaffective contexts. Findings of these studies indicate the need to look at the differences in the effects of the development of cognitive and affective control on decision making in children and particularly adolescents. Neuroimaging studies have shown the involvement of separable neural networks for cognitive (medial prefrontal cortex and anterior cingulate) and affective control (amygdala, ventral medial prefrontal cortex) shows that one system can affect the other also at the neural level. Hence, an understanding of the interaction and balance between the cognitive and affective brain networks may be crucial for self-regulation and decision making during the developmental period, particularly late childhood and adolescence. The chapter highlights the need for empirical investigation on the interaction between the different aspects

  10. Pipeline network expansion crucial to economic development in India

    Energy Technology Data Exchange (ETDEWEB)

    Jha, Kiran Kumar; Tandon, Anil; Sati, Vipin Chandra [Indian Oil Corporation Ltd., Sadiq Nagar, New Delhi (India)

    2008-07-01

    Oil Sector plays a crucial role in the development of a country and provides the required balance and stability to the economy. Though traditionally coal has had the largest share in the energy basket in India, oil and gas as a source of energy have gradually gained importance and it is expected that oil and gas will continue to command a significant share in the years to come. Transportation of oil and gas by pipelines, which are recognized worldwide as the most reliable and cost effective mode for transportation is a developing business in India. With the increasing demand for oil and gas, a necessity has arisen for according priority attention to develop a well-spread out pipeline network throughout the country so as to facilitate efficient transportation to various consumption centres. The country has already opened its doors to private sector within the country as well as to multinationals. Thus, considerable scope exists not only for making investments but also for consultants, equipment and material manufacturers/suppliers and contractors for providing their services to the Indian pipeline industry. With growth of the economy, the opportunities for investment in the Indian pipeline industry are likely to improve further. (author)

  11. The influence of network characteristics on costs in pharmaceutical new product development

    DEFF Research Database (Denmark)

    Buonansegna, Erika; Schultz, Carsten; Stargardt, Tom

    2015-01-01

    This paper develops a model relating prior experiences, network stability, exclusive partnership, geographical distance, and intermediation in inter-firm R&D networks to new product development (NPD) costs. The developed hypotheses are tested with unique multilevel R&D partnership data from 33...... becomes relevant for non-exclusive partnerships and dispersed networks. NPD costs also increase in more stable networks, reflecting the relevance of structural holes for control and information advantages. This study contributes to the network management literature by understanding the relation between...

  12. Novel adaptive distance relay algorithm considering the operation of 154 kV SFCL in Korean power transmission system

    International Nuclear Information System (INIS)

    Lee, S.; Lee, J.; Song, S.; Yoon, J.; Lee, B.

    2015-01-01

    Highlights: • This paper presents an outline of the new project of the 154 kV SFCL in Korea. • And then we review some protection problems for the application of 154 kV SFCLs. • This paper proposes a new adaptive protection algorithm for 154 kV SFCLs. • The developed algorithm is tested in a simple distance relay system. - Abstract: In general, SFCLs can have a negative impact on the protective coordination in power transmission system because of the variable impedance of SFCLs. It is very important to solve the protection problems of the power system for the successful application of SFCLs to real power transmission system. This paper reviews some protection problems which can be caused by the application of 154 kV SFCLs to power transmission systems in South Korea. And then we propose an adaptive protection algorithm to solve the problems. The adaptive protection algorithm uses the real time information of the SFCL system operation.

  13. Design and test of a 40-kV, 80-A, 10-msec, neutral-beam power supply series

    International Nuclear Information System (INIS)

    North, G.G.

    1977-01-01

    To meet neutral-beam source requirements, a combination series switch/regulator system has been developed that can provide up to 40-kV at 80A output for 10-ms from the continuously decaying voltage of a charged capacitor bank. The system uses 100% feedback control of a series hard tube regulator. This feedback regulator is able to maintain a 40-kV output level for 100% load variations while the source voltage for the capacitor bank is drained from an initial 55-kV down to as low as 43-kV during a 10-ms pulse. In addition to controlling the output voltage, the series regulator tube also serves the dual role of a disconnect or interrupt switch at the end of each pulse and during the frequent occurrence of a neutral-beam source fault. In the interrupt mode, complete disconnect is achieved in less than 2-μs after first observance of a fault condition; recovery times to normal operation of less than 10-μs after fault clearance can be attained if desired

  14. Design analysis of ceramic and polymer 150 kV insulators for tropical condition using quickfield software

    Science.gov (United States)

    Walukow, Stephy B.; Manjang, Salama; Zainuddin, Zahir; Samman, Faizal Arya

    2018-03-01

    This research is to analyze design of ceramic and polymer 150 kV insulators for the tropical area. The use of an insulator certainly requires an electric field. The leakage current and breakdown voltage this happens the contaminant on the surface of the insulator. This type of contaminant can be rain, dust, salt air, extreme weather (much in tropical climates), industrial pollutants and cracks on the surface resulting in collisions. The method used in this research is magnetic field and electric field isolator using Quicfield software. To get the test results variation ranges 20 kV, 70 kV and 150 kV. Side effects of magnetic and electric fields around the insulator. The simulation results show the accumulated contaminants on the surface. Planning should be done in insulator insulator on unstable insulator. Thus, the approach using this commercially available software can be applied to. Therefore, the development of further simulations on the different types of composite insulators used on.

  15. Developing a dynamic control system for mine compressed air networks

    OpenAIRE

    Van Heerden, S.W.; Pelzer, R.; Marais, J.H.

    2014-01-01

    Mines in general, make use of compressed air systems for daily operational activities. Compressed air on mines is traditionally distributed via compressed air ring networks where multiple shafts are supplied with compressed air from an integral system. These compressed air networks make use of a number of compressors feeding the ring from various locations in the network. While these mines have sophisticated control systems to control these compressors, they are not dynamic systems. Compresso...

  16. Development of Broadband Nuclear Safety Data Network (B-NSDN)

    International Nuclear Information System (INIS)

    Son, Gwang Seop; Kim, Dong Hoon; Park, Gi Yong

    2011-01-01

    Recently as introducing digital safety system in nuclear power plant, more data transmission capacity is required. Bandwidth of existing communication network is about a few Mbps. Thus data transmission quantity in recently digital safety system is beyond existing communication network's capacity. In this paper, new protocol that is suitable for safety system communication network is designed. FPGA based communication system is implemented. As result of test, effective bandwidth of B-NSDN is about 20Mbps

  17. Developing a robust wireless sensor network structure for environmental sensing

    Science.gov (United States)

    Zhang, Z.; Oroza, C.; Glaser, S. D.; Bales, R. C.; Conklin, M. H.

    2013-12-01

    The American River Hydrologic Observatory is being strategically deployed as a real-time ground-based measurement network that delivers accurate and timely information on snow conditions and other hydrologic attributes with a previously unheard of granularity of time and space. The basin-scale network involves 18 sub-networks set out at physiographically representative locations spanning the seasonally snow-covered half of the 5000 km2 American river basin. Each sub-network, covering about a 1-km2 area, consists of 10 wirelessly networked sensing nodes that continuously measure and telemeter temperature, and snow depth; plus selected locations are equipped with sensors for relative humidity, solar radiation, and soil moisture at several depths. The sensor locations were chosen to maximize the variance sampled for snow depth within the basin. Network design and deployment involves an iterative but efficient process. After sensor-station locations are determined, a robust network of interlinking sensor stations and signal repeaters must be constructed to route sensor data to a central base station with a two-way communicable data uplink. Data can then be uploaded from site to remote servers in real time through satellite and cell modems. Signal repeaters are placed for robustness of a self-healing network with redundant signal paths to the base station. Manual, trial-and-error heuristic approaches for node placement are inefficient and labor intensive. In that approach field personnel must restructure the network in real time and wait for new network statistics to be calculated at the base station before finalizing a placement, acting without knowledge of the global topography or overall network structure. We show how digital elevation plus high-definition aerial photographs to give foliage coverage can optimize planning of signal repeater placements and guarantee a robust network structure prior to the physical deployment. We can also 'stress test' the final network

  18. 5 KV low-induction capactitor battery

    International Nuclear Information System (INIS)

    Babalin, A.I.; Burtsev, V.A.; Emel'yanov, A.I.; Kunaev, G.T.; Ovsyannikov, V.A.; Zhmodikov, B.S.

    1981-01-01

    A 1.2 MJ capacitor battery is developed and constructed for creating strong magnetic fields for thermonuclear facilities, pumping of laser active media. The capacitor battery is assembled of 512 IMU5-150 and 128 IS5-200 capacitors. The design is based on division of the capacitor battery in 40 sections. The energy commutation is performed by air spark gaps of the trigatron type with 24 to 60 nH inductance. Electromagnetic switches are made on the base of the EP 41V-33 relay. A low-induction generator is developed for spark gap ignition. The capacitor sections, each of them comprising 16 capacitors, and loadings are switched-in either by means of cables or flat lines. Accidents were not observed during operation of 20 sections of the capacitor battery (capacitors break-down, break of polyethylene isolation, deformation of tyre-wires) [ru

  19. 77 FR 60680 - Development of the Nationwide Interoperable Public Safety Broadband Network

    Science.gov (United States)

    2012-10-04

    ... public comment on the conceptual network architecture presentation made at the FirstNet Board of... business plan considerations. NTIA also seeks comment on the general concept of how to develop applications... network based on a single, nationwide network architecture called for under the Middle Class Tax Relief...

  20. Development of 'health and environmental safety assessment network system (HESANS)'

    International Nuclear Information System (INIS)

    Nakamura, Yuji

    1994-01-01

    With the recent advance of the utilization of nuclear energy in a large scale, social interest is being focussed in the potential risk which the nuclear technology will accompany. Especially after the accidents in Chernobyl and other nuclear facilities, serious anxiety to the utilization of nuclear energy is prevailing among the general public. In order to meet the anxiety and distrust of the population in the use of the nuclear power, the health effect or risk which radioactive materials released into the environment will bring about should be comprehensively and properly evaluated, and then should be widely reported to the population. The development of HESANS code system (Health and Environmental Safety Assessment Network System) was planned to set up such a comprehensive computer code that covers a whole pathway of radioactive material from its release to estimates of derived health effects in the population, including the countermeasures for intervention as well. Though the whole system is not totally completed yet so far, the framework of the system has been concreted together with many sub-systems which compose the main part of the code. This report puts main stress on the objective of the development project and the main frame or the structure of the code system. (author)

  1. The short-circuit test results of 6.9 kV/2.3 kV 400 kVA-class YBCO model transformer with fault current limiting function

    International Nuclear Information System (INIS)

    Tomioka, A.; Bohno, T.; Kakami, S.; Isozaki, M.; Watanabe, K.; Toyama, K.; Sugiyama, S.; Konno, M.; Gosho, Y.; Okamoto, H.; Hayashi, H.; Tsutsumi, T.; Iwakuma, M.; Saito, T.; Tanabe, K.; Shiohara, Y.

    2013-01-01

    Highlights: ► We manufactured the 400 kV A-class YBCO model transformer with FCL function. ► Short-circuit test was performed by applying 6.9 kV on primary side. ► The short-circuit current was limited to 174 A for a prospective current of 559 A. ► It agreed with the design and we also confirmed the I c did not degrade. ► The results suggest the possibility to design YBCO transformers with FCL function. -- Abstract: We are developing an elemental technology for 66/6.9 kV 20 MVA-class superconducting power transformer with fault current limiting function. In order to obtain the characteristics of YBCO conductor when the AC over current supplied to the conductor, the model coils were manufactured with YBCO tapes and tested. Based on these results, we manufactured the 6.9 kV/2.3 kV 400 kVA-class YBCO model transformer with fault current limiting function and performed short-circuit test. At the 0.25 s after short-circuit, the short-circuit current of primary winding was limited to about 174 A for a prospective current of 559 A. It was consistent with the design. The I–V characteristics of the winding did not change before and after the test. We consider the model transformer to be able to withstand AC over-current with the function of current limiting. The results suggest the possibility to design YBCO superconducting transformers with fault current limiting function for practical power grid

  2. Drivers and barriers to the development of local food networks in rural Denmark

    DEFF Research Database (Denmark)

    Eriksen, Safania Normann; Sundbo, Jon

    2016-01-01

    This article examines the growing interest in local food by focusing on local food networks. The objective is to explore what factors drive or hinder the development of local food networks in rural Denmark. For this purpose, we have combined three bodies of theory: local food networks; entrepreneur...... networks; and the experience economy. This provides a valuable contribution to the current discourse on local food networks, as it introduces a novel framework to investigate the localisation of food dynamics. The article presents an explorative, case-based investigation of three Danish local food networks....... The findings demonstrate that the main drivers of the development of local food networks are the pursuance of transparency and knowledge of origin, the existence of entrepreneurship potential, the coordination of networks by means of joint strategies, and the overcoming of conflict patterns. However...

  3. 35-kV GaAs subnanosecond photoconductive switches

    Energy Technology Data Exchange (ETDEWEB)

    Pocha, M.D.; Druce, R.L. (Lawrence Livermore National Lab., CA (United States))

    1990-12-01

    Photoconductive switches are one of the few devices that allow the generation of high-voltage electrical pulses with subnanosecond rise time. The authors are exploring high-voltage, fast-pulse generation using GaAs photoconductive switches. They have been able to generate 35-kV pulses with rise times as short as 135 ps using 5-mm gap switches and have achieved electric field hold-off of greater than 100 kV/cm. They have also been able to generate an approximately 500-ps FWHM on/off electrical pulse with an amplitude of approximately 3 kV using neutron-irradiated GaAs having short carrier life times. This paper describes the experimental results and discusses fabrication of switches and the diagnostics used to measure these fast signals. They also describe the experience with the nonlinear lock-on and avalanche modes of operation observed in GaAs.

  4. 35-kV GaAs subnanosecond photoconductive switches

    Science.gov (United States)

    Pocha, Michael D.; Druce, Robert L.

    1990-12-01

    High-voltage, fast-pulse generation using GaAs photoconductive switches is investigated. It is possible to to generate 35-kV pulses with risetimes as short as 135 ps using 5-mm gap switches, and electric field hold-off of greater than 100 kV/cm is achieved. An approximately 500-ps FWHM on/off electrical pulse is generated with an amplitude of approximately 3 kV using neutron-irradiated GaAs having short carrier lifetimes. Experimental results are described, and fabrication of switches and the diagnostics used to measure these fast signals are discussed. Experience with the nonlinear lock-on and avalanche modes of operation observed in GaAs is also described.

  5. CIAE 600 kV ns pulse neutron generator

    International Nuclear Information System (INIS)

    Shen Guanren; Guan Xialing; Chen Hongtao

    2001-01-01

    The overall composition of CIAE 600 kV ns Pulse Neutron Generator (CPNG) are introduced, and its characteristic, main technological performance and application were also given. CPNG consists of high voltage power supply with highest output voltage 600 kV, direct current 15 mA, stability and ripple ≤0.1%, 2214 mm x 1604 mm x 1504 mm stainless steel high voltage electrode, built in head equipment uniform field accelerating tube, ns pulsed installation, turbomolecular vacuum pump system and drift pipes at 0 degree and 45 degree. Its characteristics are: (1) high current beam; (2) high current beam ns pulsed installation made use of low energy for chopper and high energy for buncher; (3) compactly laid out and simple in structure

  6. CEBAF 200 kV Inverted Electron Gun

    International Nuclear Information System (INIS)

    Grames, J.M.; Adderley, P.A.; Clark, J.; Hansknecht, J.; Poelker, M.; Stutzman, M.L.; Suleiman, R.; Surles-Law, K.E.L.

    2011-01-01

    Two DC high voltage GaAs photoguns have been built at Jefferson Lab based on a compact inverted insulator design. One photogun provides the polarized electron beam at CEBAF and operates at 130 kV bias voltage. The other gun is used for high average current lifetime studies at a dedicated test facility and has been operated at bias voltage up to 225 kV. The advantages of higher DC voltage for CEBAF include reduced space-charge emittance growth and the potential for prolonged photocathode lifetime. However, a consequence of operating at higher voltages is the increased likelihood of field emission or breakdown, both of which are unacceptable. Highlights of the R and D studies leading toward a production 200keV GaAs photogun for CEBAF will be presented.

  7. Improved 50-kV pulser design

    International Nuclear Information System (INIS)

    Oicles, J.A.; Fulkerson, E.S.

    1982-01-01

    A compact 50 kilovolt pulser has been developed as a gas switch trigger. This unit combines a grounded grid thyratron with a ferrite loaded step-up transformer to provide the required output voltage. A magnetic switch at the output brings the risetime down to the ten nanosecond range. Unit operation is specified into a 25 ohm resistive load. Integral with the pulser package is the necessary low level support electronics to power the thyratron and to provide trigger and diagnostic functions. Package volume is less than .02 m 3

  8. Bladder contractility is modulated by Kv7 channels in pig detrusor

    DEFF Research Database (Denmark)

    Svalø, Julie; Bille, Michala; Parameswaran Theepakaran, Neeraja

    2013-01-01

    Kv7 channels are involved in smooth muscle relaxation, and accordingly we believe that they constitute potential targets for the treatment of overactive bladder syndrome. We have therefore used myography to examine the function of Kv7 channels in detrusor, i.e. pig bladder, with a view...... relaxation, suggesting that Kv7.2 and/or Kv7.4 channels constitute the subtypes that are relevant to bladder contractility. The effects of retigabine and ML213 were attenuated by pre-incubation with 10µM XE991 (Kv7.1-7.5 channel blocker) (P...

  9. Social Network Sites: A Starting Point for Career Development Practitioners

    Science.gov (United States)

    Strehlke, Christina

    2010-01-01

    This action research study explores the career influence of social network sites (SNSs) by examining 14 web-based articles that consider the risks and opportunities of SNSs from a job search perspective. Three themes are discussed: user visibility, self-presentation, and network connections. Practical strategies are identified to help career…

  10. Development of Attention Networks and Their Interactions in Childhood

    Science.gov (United States)

    Pozuelos, Joan P.; Paz-Alonso, Pedro M.; Castillo, Alejandro; Fuentes, Luis J.; Rueda, M. Rosario

    2014-01-01

    In the present study, we investigated developmental trajectories of alerting, orienting, and executive attention networks and their interactions over childhood. Two cross-sectional experiments were conducted with different samples of 6-to 12-year-old children using modified versions of the attention network task (ANT). In Experiment 1 (N = 106),…

  11. CONTRIBUTIONS OF INTRACELLULAR IONS TO Kv CHANNEL VOLTAGE SENSOR DYNAMICS.

    Directory of Open Access Journals (Sweden)

    Samuel eGoodchild

    2012-06-01

    Full Text Available Voltage sensing domains of Kv channels control ionic conductance through coupling of the movement of charged residues in the S4 segment to conformational changes at the cytoplasmic region of the pore domain, that allow K+ ions to flow. Conformational transitions within the voltage sensing domain caused by changes in the applied voltage across the membrane field are coupled to the conducting pore region and the gating of ionic conductance. However, several other factors not directly linked to the voltage dependent movement of charged residues within the voltage sensor impact the dynamics of the voltage sensor, such as inactivation, ionic conductance, intracellular ion identity and block of the channel by intracellular ligands. The effect of intracellular ions on voltage sensor dynamics is of importance in the interpretation of gating current measurements and the physiology of pore/voltage sensor coupling. There is a significant amount of variability in the reported kinetics of voltage sensor deactivation kinetics of Kv channels attributed to different mechanisms such as open state stabilization, immobilization and relaxation processes of the voltage sensor. Here we separate these factors and focus on the causal role that intracellular ions can play in allosterically modulating the dynamics of Kv voltage sensor deactivation kinetics. These considerations are of critical importance in understanding the molecular determinants of the complete channel gating cycle from activation to deactivation.

  12. The importance of immunohistochemical analyses in evaluating the phenotype of Kv channel knockout mice.

    Science.gov (United States)

    Menegola, Milena; Clark, Eliana; Trimmer, James S

    2012-06-01

    To gain insights into the phenotype of voltage-gated potassium (Kv)1.1 and Kv4.2 knockout mice, we used immunohistochemistry to analyze the expression of component principal or α subunits and auxiliary subunits of neuronal Kv channels in knockout mouse brains. Genetic ablation of the Kv1.1 α subunit did not result in compensatory changes in the expression levels or subcellular distribution of related ion channel subunits in hippocampal medial perforant path and mossy fiber nerve terminals, where high levels of Kv1.1 are normally expressed. Genetic ablation of the Kv4.2 α subunit did not result in altered neuronal cytoarchitecture of the hippocampus. Although Kv4.2 knockout mice did not exhibit compensatory changes in the expression levels or subcellular distribution of the related Kv4.3 α subunit, we found dramatic decreases in the cellular and subcellular expression of specific Kv channel interacting proteins (KChIPs) that reflected their degree of association and colocalization with Kv4.2 in wild-type mouse and rat brains. These studies highlight the insights that can be gained by performing detailed immunohistochemical analyses of Kv channel knockout mouse brains. Wiley Periodicals, Inc. © 2012 International League Against Epilepsy.

  13. FPGA based control system for -100 kV, 25 A Crowbarless DC power supply

    International Nuclear Information System (INIS)

    Upadhyay, R.; Tripathi, A.; Badapanda, M.K.; Lad, M.

    2015-01-01

    FPGA based digital control system has been developed for -100 kV, 25 A solid state modular crowbarless DC klystron bias power supply of 1 MW, 352.2 MHz RF test stand. The control system has capability to operate this power supply either in CW or pulse mode. Central controller, PSM controller and graphical user interface are key parts of this control system. Central controller monitors the status of various subsystems of this power supply like 11 kV step start unit, four numbers of main transformers each having 44 numbers of secondary windings and 176 numbers of switch power modules for deciding the number of power modules to be put ON and their duty cycles depending on the set output voltage and current. PSM controller sends appropriate control signal to the switch power modules through fibre optic lines and communicates it to the central controller. Linux based graphical user interface has been developed which enables the user to set the operating parameters along with their trip limits and displays the information of critical parameters of this power supply on a local touch screen panel. Provision for remote control and supervision is also provided through a separate PC connected to the main control system via Ethernet. The control system has capability to trip the power supply within 5 μsec in case any parameter exceeds its set limit. Suitable data logging feature is incorporated for offline fault analysis. The control system architecture along with its software protection interlocks are presented in this paper. The performance of the control system has been verified during operation of -100 kV, 25 A DC power supply with 1 MW, 352.2 MHz klystron amplifier. (author)

  14. Social Networks, Psychosocial Adaptation, and Preventive/Developmental Interventions: The Support Development Workshop.

    Science.gov (United States)

    Todd, David M.

    The Support Development Group is an approach which explores and develops a theory for the relationship between network characteristics and notions of psychosocial adaptation. The approach is based on the assumption that teaching people to view their social world in network terms can be helpful to them. The Support Development Workshop is presented…

  15. Developing noise control strategies for entire railway networks

    Science.gov (United States)

    Oertli, Jakob

    2006-06-01

    The EU Environmental Noise Directive (2002/49) requires member states to deliver noise maps to the commission by 2007 and action plans by 2008 both for agglomerations as well as for major roads, railways and airports. Noise mitigation projects resulting from action plans are usually very expensive and therefore may threaten the economic viability of the railways in the current harsh competitive transport market, thus hindering sustainable transport policies. It is therefore of vital interest that the action plans and the resulting projects are designed in the most cost-effective way possible. The EU and Union of Railways (UIC) sponsored project Strategies and Tools to Assess and Implement noise Reducing measures for Railway Systems (STAIRRS) recognized this need and developed a tool, with which such optimal solutions can be obtained for entire railway networks. Since data collection is the most expensive part of the analysis, noise mapping data is ideally collected in such a way that it can be used for the calculation of the different scenarios, from which the most cost-effective action plans are chosen. The paper shows how the STAIRRS tool is used for this purpose and how cost-effectiveness considerations have led to optimal railway noise mitigation strategies in Switzerland and have given a basis for noise related decision making in Luxembourg.

  16. Development of wireless sensor network for landslide monitoring system

    International Nuclear Information System (INIS)

    Suryadi; Puranto, Prabowo; Adinanta, Hendra; Tohari, Adrin; Priambodo, Purnomo S

    2017-01-01

    A wireless sensor network has been developed to monitor soil movement of some observed areas periodically. The system consists of four nodes and one gateway which installed on a scope area of 0.2 Km 2 . Each of nodehastwo types of sensor,an inclinometer and an extensometer. An inclinometer sensor is used to measure the tilt of a structure while anextensometer sensor is used to measure the displacement of soil movement. Each of nodeisalso supported by awireless communication device, a solar power supply unit, and a microcontroller unit called sensor module. In this system, there is also gateway module as a main communication system consistinga wireless communication device, power supply unit, and rain gauge to measure the rainfall intensity of the observed area. Each sensor of inclinometer and extensometer isconnected to the sensor module in wiring system but sensor module iscommunicating with gateway in a wireless system. Those four nodes are alsoconnectedeach other in a wireless system collecting the data from inclinometer and extensometer sensors. Module Gateway istransmitting the instruction code to each sensor module one by one and collecting the data from them. Gateway module is an important part to communicate with not only sensor modules but also to the server. This wireless system wasdesigned toreducethe electric consumption powered by 80 WP solar panel and 55Ah battery. This system has been implemented in Pangalengan, Bandung, which has high intensity of rainfall and it can be seen on the website. (paper)

  17. Optimizing Electric Vehicle Coordination Over a Heterogeneous Mesh Network in a Scaled-Down Smart Grid Testbed

    DEFF Research Database (Denmark)

    Bhattarai, Bishnu Prasad; Lévesque, Martin; Maier, Martin

    2015-01-01

    High penetration of renewable energy sources and electric vehicles (EVs) create power imbalance and congestion in the existing power network, and hence causes significant problems in the control and operation. Despite investing huge efforts from the electric utilities, governments, and researchers......, smart grid (SG) is still at the developmental stage to address those issues. In this regard, a smart grid testbed (SGT) is desirable to develop, analyze, and demonstrate various novel SG solutions, namely demand response, real-time pricing, and congestion management. In this paper, a novel SGT...... is developed in a laboratory by scaling a 250 kVA, 0.4 kV real low-voltage distribution feeder down to 1 kVA, 0.22 kV. Information and communication technology is integrated in the scaled-down network to establish real-time monitoring and control. The novelty of the developed testbed is demonstrated...

  18. Developing a New HSR Switching Node (SwitchBox for Improving Traffic Performance in HSR Networks

    Directory of Open Access Journals (Sweden)

    Nguyen Xuan Tien

    2016-01-01

    Full Text Available High availability is crucial for industrial Ethernet networks as well as Ethernet-based control systems such as automation networks and substation automation systems (SAS. Since standard Ethernet does not support fault tolerance capability, the high availability of Ethernet networks can be increased by using redundancy protocols. Various redundancy protocols for Ethernet networks have been developed and standardized, such as rapid spanning tree protocol (RSTP, media redundancy protocol (MRP, parallel redundancy protocol (PRP, high-availability seamless redundancy (HSR and others. RSTP and MRP have switchover delay drawbacks. PRP provides zero recovery time, but requires a duplicate network infrastructure. HSR operation is similar to PRP, but HSR uses a single network. However, the standard HSR protocol is mainly applied to ring-based topologies and generates excessively unnecessary redundant traffic in the network. In this paper, we develop a new switching node for the HSR protocol, called SwitchBox, which is used in HSR networks in order to support any network topology and significantly reduce redundant network traffic, including unicast, multicast and broadcast traffic, compared with standard HSR. By using the SwitchBox, HSR not only provides seamless communications with zero switchover time in case of failure, but it is also easily applied to any network topology and significantly reduces unnecessary redundant traffic in HSR networks.

  19. Planning of Distribution Networks in Baghdad City

    Directory of Open Access Journals (Sweden)

    Thamir M. Abdul-Wahhab

    2015-02-01

    Full Text Available Planning of electrical distribution networks is considered of highest priority at the present time in Iraq, due to the huge increase in electrical demand and expansions imposed on distribution networks as a result of the great and rapid urban development. Distribution system planning simulates and studies the behavior of electrical distribution networks under different operating conditions. The study provide understanding of the existing system and to prepare a short term development plan or a long term plan used to guide system expansion and future investments needed for improved network performance. The objective of this research is the planning of Al_Bayaa 11 kV distribution network in Baghdad city based on the powerful and efficient CYMDist software as a tool for the simulation and analysis of the network. The planning method proposed in this thesis is to reach the optimum operating conditions of the network by combining the network reconfiguration in sequence with the insertion of capacitors with optimal sizing and locations. The optimum performance of the network is achieved by reducing losses, improving voltage profile and alleviating overload for transformers and cables.

  20. Development Interventions and Agriculture Adaptation: A Social Network Analysis of Farmer Knowledge Transfer in Ghana

    Directory of Open Access Journals (Sweden)

    Kirstie Cadger

    2016-07-01

    Full Text Available Social ties play an important role in agricultural knowledge exchange, particularly in developing countries with high exposure to agriculture development interventions. Institutions often facilitate agricultural training projects, with a focus on agroecological practices, such as agroforestry and agrobiodiversity. The structural characteristics of social networks amongst land managers influences decision-making to adopt such adaptive agroecoloigcal practice; however, the extent of knowledge transfer beyond direct project participants is often unknown. Using a social network approach, we chart the structure of agrarian knowledge networks (n = 131 in six communities, which have been differentially exposed to agriculture development interventions in Ghana. Farmer network size, density and composition were distinctly variable; development project-affiliated farmers were embedded in larger networks, had non-affiliated farmers within their networks, were engaged in more diverse agricultural production and reported adopting and adapting agroecological practice more frequently. Such bridging ties that link across distinctive groups in a network can expose network members to new and innovative agroecological practices, such as increasing agrobiodiversity, thus, contributing to livelihood strategies that mitigate environmental and market risk. Furthermore, we show that these knowledge networks were crop-specific where network size varied given the type of crop produced. Such factors, which may influence the rate and extent of agroecological knowledge diffusion, are critical for the effectiveness of land management practices as well as the persistence of agriculture development interventions.

  1. Detection of silent cells, synchronization and modulatory activity in developing cellular networks.

    Science.gov (United States)

    Hjorth, Johannes J J; Dawitz, Julia; Kroon, Tim; Pires, Johny; Dassen, Valerie J; Berkhout, Janna A; Emperador Melero, Javier; Nadadhur, Aish G; Alevra, Mihai; Toonen, Ruud F; Heine, Vivi M; Mansvelder, Huibert D; Meredith, Rhiannon M

    2016-04-01

    Developing networks in the immature nervous system and in cellular cultures are characterized by waves of synchronous activity in restricted clusters of cells. Synchronized activity in immature networks is proposed to regulate many different developmental processes, from neuron growth and cell migration, to the refinement of synapses, topographic maps, and the mature composition of ion channels. These emergent activity patterns are not present in all cells simultaneously within the network and more immature "silent" cells, potentially correlated with the presence of silent synapses, are prominent in different networks during early developmental periods. Many current network analyses for detection of synchronous cellular activity utilize activity-based pixel correlations to identify cellular-based regions of interest (ROIs) and coincident cell activity. However, using activity-based correlations, these methods first underestimate or ignore the inactive silent cells within the developing network and second, are difficult to apply within cell-dense regions commonly found in developing brain networks. In addition, previous methods may ignore ROIs within a network that shows transient activity patterns comprising both inactive and active periods. We developed analysis software to semi-automatically detect cells within developing neuronal networks that were imaged using calcium-sensitive reporter dyes. Using an iterative threshold, modulation of activity was tracked within individual cells across the network. The distribution pattern of both inactive and active, including synchronous cells, could be determined based on distance measures to neighboring cells and according to different anatomical layers. © 2015 Wiley Periodicals, Inc.

  2. APECS: A Network for Polar Early Career Scientist Professional Development

    Science.gov (United States)

    Enderlin, E. M.

    2014-12-01

    informal meet-ups, providing a means to personally interact with a subset of APECS' 4725 members. The combination of in-person and online activities and resources hosted/organized by APECS provides members with unique opportunities for networking, career development, and international and interdisciplinary collaboration.

  3. The Role of Network Administrative Organizations in the Development of Social Capital in Inter‐Organizational Food Networks

    Directory of Open Access Journals (Sweden)

    Virginie M. Lefebvre

    2013-02-01

    Full Text Available This paper is concerned with the role of network administrative organizations (NAOs in the development of social capital in inter‐organizational networks aiming at supporting their members to innovate in the food sector through interacting with one another. A multi‐case study approach is used whereby three Belgian inter‐organizational networks are investigated i.e. Wagralim, Réseau‐Club and Flanders Food. Our study shows that there are many options available to NAOs to build social capital within the networks they are responsible for; options which we propose to categorize in three main distinct groups: creation of boundary objects, careful selection of members and effective communication.

  4. Development of an accident diagnosis system using a dynamic neural network for nuclear power plants

    International Nuclear Information System (INIS)

    Lee, Seung Jun; Kim, Jong Hyun; Seong, Poong Hyun

    2004-01-01

    In this work, an accident diagnosis system using the dynamic neural network is developed. In order to help the plant operators to quickly identify the problem, perform diagnosis and initiate recovery actions ensuring the safety of the plant, many operator support system and accident diagnosis systems have been developed. Neural networks have been recognized as a good method to implement an accident diagnosis system. However, conventional accident diagnosis systems that used neural networks did not consider a time factor sufficiently. If the neural network could be trained according to time, it is possible to perform more efficient and detailed accidents analysis. Therefore, this work suggests a dynamic neural network which has different features from existing dynamic neural networks. And a simple accident diagnosis system is implemented in order to validate the dynamic neural network. After training of the prototype, several accident diagnoses were performed. The results show that the prototype can detect the accidents correctly with good performances

  5. INNOVATION NETWORKS AND MARKETING MIX: AN EXPLORATORY STUDY ON PRODUCT'S DEVELOPMENT

    Directory of Open Access Journals (Sweden)

    Thel Augusto Monteiro

    2013-12-01

    Full Text Available The purpose of this paper is to present how innovation networks can be used to develop a new product or service, using the marketing compound. The study methodology consists of an exploratory research from literature review on this subject. After an initial discussion of the characteristics of innovation networks and marketing functions, the study presents proposals that allow adequately addressing the main difficulties in the management of marketing in innovation networks. Through this study it can be stated that these networks have been identified as an attractive alternative for the development of new products, when using the marketing mix, given the dynamics of the contemporary market. Innovation networks bring a lot of benefits to companies that embrace the relationship between these networks and marketing. The discussion reveals that the structure in the form of innovation networks can bring effective results in the organization which adopt it, providing competitiveness and adaptability in the face of its target market.

  6. Spectrum regulation for future internet networks in developing economies

    CSIR Research Space (South Africa)

    Somdyala, B

    2017-05-01

    Full Text Available to flourish and provide the necessary socio-economic benefit. This paper presents research to support formulation of the dynamic spectrum regulatory framework including co-existence techniques, interference avoidance and network device technology aspects...

  7. Resilience of developing brain networks to interictal epileptiform discharges is associated with cognitive outcome.

    Science.gov (United States)

    Ibrahim, George M; Cassel, Daniel; Morgan, Benjamin R; Smith, Mary Lou; Otsubo, Hiroshi; Ochi, Ayako; Taylor, Margot; Rutka, James T; Snead, O Carter; Doesburg, Sam

    2014-10-01

    The effects of interictal epileptiform discharges on neurocognitive development in children with medically-intractable epilepsy are poorly understood. Such discharges may have a deleterious effect on the brain's intrinsic connectivity networks, which reflect the organization of functional networks at rest, and in turn on neurocognitive development. Using a combined functional magnetic resonance imaging-magnetoencephalography approach, we examine the effects of interictal epileptiform discharges on intrinsic connectivity networks and neurocognitive outcome. Functional magnetic resonance imaging was used to determine the location of regions comprising various intrinsic connectivity networks in 26 children (7-17 years), and magnetoencephalography data were reconstructed from these locations. Inter-regional phase synchronization was then calculated across interictal epileptiform discharges and graph theoretical analysis was applied to measure event-related changes in network topology in the peri-discharge period. The magnitude of change in network topology (network resilience/vulnerability) to interictal epileptiform discharges was associated with neurocognitive outcomes and functional magnetic resonance imaging networks using dual regression. Three main findings are reported: (i) large-scale network changes precede and follow interictal epileptiform discharges; (ii) the resilience of network topologies to interictal discharges is associated with stronger resting-state network connectivity; and (iii) vulnerability to interictal discharges is associated with worse neurocognitive outcomes. By combining the spatial resolution of functional magnetic resonance imaging with the temporal resolution of magnetoencephalography, we describe the effects of interictal epileptiform discharges on neurophysiological synchrony in intrinsic connectivity networks and establish the impact of interictal disruption of functional networks on cognitive outcome in children with epilepsy. The

  8. Networked Learning and Network Science: Potential Applications to Health Professionals' Continuing Education and Development.

    Science.gov (United States)

    Margolis, Alvaro; Parboosingh, John

    2015-01-01

    Prior interpersonal relationships and interactivity among members of professional associations may impact the learning process in continuing medical education (CME). On the other hand, CME programs that encourage interactivity between participants may impact structures and behaviors in these professional associations. With the advent of information and communication technologies, new communication spaces have emerged that have the potential to enhance networked learning in national and international professional associations and increase the effectiveness of CME for health professionals. In this article, network science, based on the application of network theory and other theories, is proposed as an approach to better understand the contribution networking and interactivity between health professionals in professional communities make to their learning and adoption of new practices over time. © 2015 The Alliance for Continuing Education in the Health Professions, the Society for Academic Continuing Medical Education, and the Council on Continuing Medical Education, Association for Hospital Medical Education.

  9. Developing Simulated Cyber Attack Scenarios Against Virtualized Adversary Networks

    Science.gov (United States)

    2017-03-01

    enclave, as shown in Figure 11, is a common design for many secure networks. Different variations of a cyber-attack scenario can be rehearsed based...achieved a greater degree of success against multiple variations of an enemy network. E. ATTACK TYPES A primary goal of this thesis is to define and...2013. [33] R. Goldberg , “Architectural principles for virtual computer systems,” Ph.D. dissertation, Dept. of Comp. Sci., Harvard Univ., Cambridge

  10. State of the art survey of network operating systems development

    Science.gov (United States)

    1985-01-01

    The results of the State-of-the-Art Survey of Network Operating Systems (NOS) performed for Goddard Space Flight Center are presented. NOS functional characteristics are presented in terms of user communication data migration, job migration, network control, and common functional categories. Products (current or future) as well as research and prototyping efforts are summarized. The NOS products which are revelant to the space station and its activities are evaluated.

  11. Distance Protection Impedance Measurement for Inhomogeneous Multiple-Circuit 400/150 kV Transmission Lines with Shared Towers

    DEFF Research Database (Denmark)

    Bak, Claus Leth; Sigurbjörnsson, Ragnar; Bukh, Bjarne

    2016-01-01

    are interconnected in a simple way but via transformers and infeed from remaining parts of the network. Distance relay measured fault loop impedance shows wide ranges of variations for both phase-phase loops as well as phase-earth loops. No simple relations exist. Simulation models can be used to study fault loop...... impedance for combined faults and thereby shed light on relay trips. This study uses actual fault records, analytical method and PSCAD simulation studies to analyse combined faults in an existing 400 and 150 kV transmission line owned by Danish TSO Energinet.dk. The results clearly show that an accurate...

  12. Impact of SSSC on Measured Impedance in Single Phase to Ground Fault Condition on 220 kV Transmission Line

    Directory of Open Access Journals (Sweden)

    Mohamed ZELLAGUI

    2012-08-01

    Full Text Available This paper presents and compares the impact of SSSC on measured impedance for single phase to ground fault condition. The presence of Static Synchronous SSSC on a transmission line has a great influence on the ZRelay in distance protection. The protection of the high voltage 220 kV single circuit transmission line in eastern Algerian electrical transmission networks is affected in the case with resistance fault RF. The paper investigate the effect of Static Synchronous Series Compensator (SSSC on the measured impedance (Relay taking into account the distance fault point (n and fault resistance (RF. The resultants simulation is performed in MATLAB software environment.

  13. Dynamic robustness of knowledge collaboration network of open source product development community

    Science.gov (United States)

    Zhou, Hong-Li; Zhang, Xiao-Dong

    2018-01-01

    As an emergent innovative design style, open source product development communities are characterized by a self-organizing, mass collaborative, networked structure. The robustness of the community is critical to its performance. Using the complex network modeling method, the knowledge collaboration network of the community is formulated, and the robustness of the network is systematically and dynamically studied. The characteristics of the network along the development period determine that its robustness should be studied from three time stages: the start-up, development and mature stages of the network. Five kinds of user-loss pattern are designed, to assess the network's robustness under different situations in each of these three time stages. Two indexes - the largest connected component and the network efficiency - are used to evaluate the robustness of the community. The proposed approach is applied in an existing open source car design community. The results indicate that the knowledge collaboration networks show different levels of robustness in different stages and different user loss patterns. Such analysis can be applied to provide protection strategies for the key users involved in knowledge dissemination and knowledge contribution at different stages of the network, thereby promoting the sustainable and stable development of the open source community.

  14. WE-G-18A-02: Calibration-Free Combined KV/MV Short Scan CBCT

    Energy Technology Data Exchange (ETDEWEB)

    Wu, M; Loo, B; Bazalova, M; Fahrig, R [Stanford University, Stanford, CA (United States); Star-Lack, J [Varian Medical Systems, Palo Alto, CA (United States)

    2014-06-15

    Purpose: To combine orthogonal kilo-voltage (kV) and Mega-voltage (MV) projection data for short scan cone-beam CT to reduce imaging time on current radiation treatment systems, using a calibration-free gain correction method. Methods: Combining two orthogonal projection data sets for kV and MV imaging hardware can reduce the scan angle to as small as 110° (90°+fan) such that the total scan time is ∼18 seconds, or within a breath hold. To obtain an accurate reconstruction, the MV projection data is first linearly corrected using linear regression using the redundant data from the start and end of the sinogram, and then the combined data is reconstructed using the FDK method. To correct for the different changes of attenuation coefficients in kV/MV between soft tissue and bone, the forward projection of the segmented bone and soft tissue from the first reconstruction in the redundant region are added to the linear regression model. The MV data is corrected again using the additional information from the segmented image, and combined with kV for a second FDK reconstruction. We simulated polychromatic 120 kVp (conventional a-Si EPID with CsI) and 2.5 MVp (prototype high-DQE MV detector) projection data with Poisson noise using the XCAT phantom. The gain correction and combined kV/MV short scan reconstructions were tested with head and thorax cases, and simple contrast-to-noise ratio measurements were made in a low-contrast pattern in the head. Results: The FDK reconstruction using the proposed gain correction method can effectively reduce artifacts caused by the differences of attenuation coefficients in the kV/MV data. The CNRs of the short scans for kV, MV, and kV/MV are 5.0, 2.6 and 3.4 respectively. The proposed gain correction method also works with truncated projections. Conclusion: A novel gain correction and reconstruction method was developed to generate short scan CBCT from orthogonal kV/MV projections. This work is supported by NIH Grant 5R01CA138426-05.

  15. Rapid internalization of the oncogenic K+ channel K(V10.1.

    Directory of Open Access Journals (Sweden)

    Tobias Kohl

    Full Text Available K(V10.1 is a mammalian brain voltage-gated potassium channel whose ectopic expression outside of the brain has been proven relevant for tumor biology. Promotion of cancer cell proliferation by K(V10.1 depends largely on ion flow, but some oncogenic properties remain in the absence of ion permeation. Additionally, K(V10.1 surface populations are small compared to large intracellular pools. Control of protein turnover within cells is key to both cellular plasticity and homeostasis, and therefore we set out to analyze how endocytic trafficking participates in controlling K(V10.1 intracellular distribution and life cycle. To follow plasma membrane K(V10.1 selectively, we generated a modified channel of displaying an extracellular affinity tag for surface labeling by α-bungarotoxin. This modification only minimally affected K(V10.1 electrophysiological properties. Using a combination of microscopy and biochemistry techniques, we show that K(V10.1 is constitutively internalized involving at least two distinct pathways of endocytosis and mainly sorted to lysosomes. This occurs at a relatively fast rate. Simultaneously, recycling seems to contribute to maintain basal K(V10.1 surface levels. Brief K(V10.1 surface half-life and rapid lysosomal targeting is a relevant factor to be taken into account for potential drug delivery and targeting strategies directed against K(V10.1 on tumor cells.

  16. The Watts-Strogatz network model developed by including degree distribution: theory and computer simulation

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Y W [Surface Physics Laboratory and Department of Physics, Fudan University, Shanghai 200433 (China); Zhang, L F [Surface Physics Laboratory and Department of Physics, Fudan University, Shanghai 200433 (China); Huang, J P [Surface Physics Laboratory and Department of Physics, Fudan University, Shanghai 200433 (China)

    2007-07-20

    By using theoretical analysis and computer simulations, we develop the Watts-Strogatz network model by including degree distribution, in an attempt to improve the comparison between characteristic path lengths and clustering coefficients predicted by the original Watts-Strogatz network model and those of the real networks with the small-world property. Good agreement between the predictions of the theoretical analysis and those of the computer simulations has been shown. It is found that the developed Watts-Strogatz network model can fit the real small-world networks more satisfactorily. Some other interesting results are also reported by adjusting the parameters in a model degree-distribution function. The developed Watts-Strogatz network model is expected to help in the future analysis of various social problems as well as financial markets with the small-world property.

  17. The Watts-Strogatz network model developed by including degree distribution: theory and computer simulation

    International Nuclear Information System (INIS)

    Chen, Y W; Zhang, L F; Huang, J P

    2007-01-01

    By using theoretical analysis and computer simulations, we develop the Watts-Strogatz network model by including degree distribution, in an attempt to improve the comparison between characteristic path lengths and clustering coefficients predicted by the original Watts-Strogatz network model and those of the real networks with the small-world property. Good agreement between the predictions of the theoretical analysis and those of the computer simulations has been shown. It is found that the developed Watts-Strogatz network model can fit the real small-world networks more satisfactorily. Some other interesting results are also reported by adjusting the parameters in a model degree-distribution function. The developed Watts-Strogatz network model is expected to help in the future analysis of various social problems as well as financial markets with the small-world property

  18. Low Emission Development Strategies: The Role of Networks and Knowledge Platforms

    Energy Technology Data Exchange (ETDEWEB)

    Benioff, Ron [National Renewable Energy Lab. (NREL), Golden, CO (United States); Bazilian, Morgan [National Renewable Energy Lab. (NREL), Golden, CO (United States); Cox, Sadie [National Renewable Energy Lab. (NREL), Golden, CO (United States); Uriarte, Caroline [National Renewable Energy Lab. (NREL), Golden, CO (United States); Kecman, Ana [United Nations Industrial Development Organization, Vienna (Austria); De Simone, Giuseppe [United Nations Industrial Development Organization, Vienna (Austria); Kitaoka, Kazuki [United Nations Industrial Development Organization, Vienna (Austria); Ploutakhina, Marina [United Nations Industrial Development Organization, Vienna (Austria); Radka, M. [United Nations Environment Programme, Nairobi (Kenya)

    2013-09-01

    Considerable effort has been made to address the transition to low-carbon economy. A key focus of these efforts has been on the development of national low-emissions developments strategies (LEDS). One enabler of these plans is the existence of well-functioning national, regional and international low-emission development networks and knowledge platforms. To better understand the role of LEDS, weexamine this area in relation to network theory. We present a review of strengths and weaknesses of existing LEDS networks that builds on the findings of a study conducted by the Coordinated Low Emission Assistance Network (CLEAN). Based on the insights from theory and a mapping of the climate-related network space, we identify opportunities for further refinement of LEDS networks.

  19. Networking in Sport Management: Ideas and Activities to Enhance Student Engagement and Career Development

    Directory of Open Access Journals (Sweden)

    Alan S. Kornspan

    2013-01-01

    Full Text Available The primary purpose of this paper is to present information regarding the development of networking skills to enhance the career development of sport management students. Specifically, literature is reviewed which supports the importance of networking in the attainment of employment and career advancement in the sport industry. This is followed by an overview of emerging networking activities that allow opportunities for sport management students to expand their network. Sport industry career fairs and career conferences that students can attend are discussed. Additionally, sport industry professional associations that students can become involved with are presented. This is then followed with information related to the development of sport management clubs and various events that can be promoted to enhance the networking process. Specifically, activities provided by university faculty to enhance the educational experience of sport management students are detailed. Finally, a sample schedule of semester activities focused on student engagement and networking activities is provided.

  20. The Role of Action Research in the Development of Learning Networks for Entrepreneurs

    Science.gov (United States)

    Brett, Valerie; Mullally, Martina; O'Gorman, Bill; Fuller-Love, Nerys

    2012-01-01

    Developing sustainable learning networks for entrepreneurs is the core objective of the Sustainable Learning Networks in Ireland and Wales (SLNIW) project. One research team drawn from the Centre for Enterprise Development and Regional Economy at Waterford Institute of Technology and the School of Management and Business from Aberystwyth…

  1. International Agro-food Chains and Networks as Instruments for Development

    NARCIS (Netherlands)

    Ruben, R.; Slingerland, M.A.; Nijhoff, H.

    2006-01-01

    Agro-food chains and networks play an increasingly important role in providing access to markets for producers from developing countries. In developing countries companies become integrated into geographically dispersed supply networks that link producers, traders and processors from the South with

  2. Network-Based Leadership Development: A Guiding Framework and Resources for Management Educators

    Science.gov (United States)

    Cullen-Lester, Kristin L.; Woehler, Meredith L.; Willburn, Phil

    2016-01-01

    Management education and leadership development has traditionally focused on improving human capital (i.e., knowledge, skills, and abilities). Social capital, networks, and networking skills have received less attention. When this content has been incorporated into learning and development experiences, it has often been more ad hoc and has…

  3. Recent development in wireless sensor and ad-hoc networks

    CERN Document Server

    Li, Xiaolong; Yang, Yeon-Mo

    2015-01-01

    Wireless Sensor Network (WSN) consists of numerous physically distributed autonomous devices used for sensing and monitoring the physical and/or environmental conditions. A WSN uses a gateway that provides wireless connectivity to the wired world as well as distributed networks. There are many open problems related to Ad-Hoc networks and its applications. Looking at the expansion of the cellular infrastructure, Ad-Hoc network may be acting as the basis of the 4th generation wireless technology with the new paradigm of ‘anytime, anywhere communications’. To realize this, the real challenge would be the security, authorization and management issues of the large scale WSNs. This book is an edited volume in the broad area of WSNs. The book covers various chapters like Multi-Channel Wireless Sensor Networks, its Coverage, Connectivity as well as Deployment. It covers comparison of various communication protocols and algorithms such as MANNET, ODMRP and ADMR Protocols for Ad hoc Multicasting, Location Based C...

  4. Development and function of human cerebral cortex neural networks from pluripotent stem cells in vitro.

    Science.gov (United States)

    Kirwan, Peter; Turner-Bridger, Benita; Peter, Manuel; Momoh, Ayiba; Arambepola, Devika; Robinson, Hugh P C; Livesey, Frederick J

    2015-09-15

    A key aspect of nervous system development, including that of the cerebral cortex, is the formation of higher-order neural networks. Developing neural networks undergo several phases with distinct activity patterns in vivo, which are thought to prune and fine-tune network connectivity. We report here that human pluripotent stem cell (hPSC)-derived cerebral cortex neurons form large-scale networks that reflect those found in the developing cerebral cortex in vivo. Synchronised oscillatory networks develop in a highly stereotyped pattern over several weeks in culture. An initial phase of increasing frequency of oscillations is followed by a phase of decreasing frequency, before giving rise to non-synchronous, ordered activity patterns. hPSC-derived cortical neural networks are excitatory, driven by activation of AMPA- and NMDA-type glutamate receptors, and can undergo NMDA-receptor-mediated plasticity. Investigating single neuron connectivity within PSC-derived cultures, using rabies-based trans-synaptic tracing, we found two broad classes of neuronal connectivity: most neurons have small numbers (40). These data demonstrate that the formation of hPSC-derived cortical networks mimics in vivo cortical network development and function, demonstrating the utility of in vitro systems for mechanistic studies of human forebrain neural network biology. © 2015. Published by The Company of Biologists Ltd.

  5. Auditing Albaha University Network Security using in-house Developed Penetration Tool

    Science.gov (United States)

    Alzahrani, M. E.

    2018-03-01

    Network security becomes very important aspect in any enterprise/organization computer network. If important information of the organization can be accessed by anyone it may be used against the organization for further own interest. Thus, network security comes into it roles. One of important aspect of security management is security audit. Security performance of Albaha university network is relatively low (in term of the total controls outlined in the ISO 27002 security control framework). This paper proposes network security audit tool to address issues in Albaha University network. The proposed penetration tool uses Nessus and Metasploit tool to find out the vulnerability of a site. A regular self-audit using inhouse developed tool will increase the overall security and performance of Albaha university network. Important results of the penetration test are discussed.

  6. Crossing the Color Line: Black Professional Men’s Development of Interracial Social Networks

    Directory of Open Access Journals (Sweden)

    Adia Harvey Wingfield

    2014-05-01

    Full Text Available Sociologists have established that social networks often play an important role in hiring, promotions, and occupational mobility. For black workers, however, social networks can be racialized in ways that work to their disadvantage. In this paper, I consider how black professional men develop and maintain interracial social networks with white men and women. I argue that these networks are shaped by intersections of race and gender and are intentionally constructed in response to black professional men’s perceptions of their positioning within male-dominated occupations. Specifically, this paper examines how black men establish social networks with white men, their perceptions of how diverging levels of social capital shape these networks compared to their white male peers, and their observations of ways that women are less advantaged than they are in constructing social networks.

  7. Feasibility Analysis of Developing Cross-border Network Education in China

    Science.gov (United States)

    Lan, Jun

    In the era of economic globalization, strengthen of international cooperation on network education is a general trend. Although China has not made commitments about the market access and national treatment of cross-border supply in Schedule of Specific Commitments on Services, the basic conditions of network education development in China have been met. The Chinese government should formulate strategies for the development of cross-border network education and take relevant measures to implement them. In the near future, the carrying out of cross-border network education in China will become an irreversible trend, and will possess broad prospect with the advance of globalization of Chinese education.

  8. INTEGRATING ARTIFICIAL NEURAL NETWORKS FOR DEVELOPING TELEMEDICINE SOLUTION

    Directory of Open Access Journals (Sweden)

    Mihaela GHEORGHE

    2015-06-01

    Full Text Available Artificial intelligence is assuming an increasing important role in the telemedicine field, especially neural networks with their ability to achieve meaning from large sets of data characterized by lacking exactness and accuracy. These can be used for assisting physicians or other clinical staff in the process of taking decisions under uncertainty. Thus, machine learning methods which are specific to this technology are offering an approach for prediction based on pattern classification. This paper aims to present the importance of neural networks in detecting trends and extracting patterns which can be used within telemedicine domains, particularly for taking medical diagnosis decisions.

  9. Design and testing of reactors for 735 kV

    Energy Technology Data Exchange (ETDEWEB)

    Erb, W; Kraaij, D J

    1965-11-01

    The design and testing of five large, single phase shunt reactors rated either 110 or 55 MVAR, supplied for the 735 kV system of the Quebec Hydro Electric Commission which came into operation in the autumn of 1965 are described. As these reactors are permanently connected to the transmission lines, their losses must be considered as being continuously present and must be determined exactly. In addition to the use of a new bridge method, the losses were also measured calorimetrically for the purpose of comparison, the agreement between the two tests being remarkably good. The impulse tests with full wave and chopped wave are subsequently described.

  10. Recent development of infrasound monitoring network in Romania

    Science.gov (United States)

    Ghica, Daniela; Popa, Mihaela; Ionescu, Constantin

    2017-04-01

    The second half of 2016 was marked at National Institute for Earth Physics (NIEP) by a significant development of infrasound monitoring infrastructure in Romania. In addition to IPLOR, the 6-element acoustic array installed at Plostina, in the central part of Romania, since 2009, two other four-element arrays were deployed. The first one, BURARI infrasound research array, was deployed in late July 2016, under a joint effort of AFTAC, USA and NIEP, in the northern part of Romania, in Bucovina region. The sites, placed in vicinity of the central elements of BURAR seismic array (over 1.2 km aperture), are equipped with Chaparral Physics Model 21 microbarometers and Reftek RT 130 data loggers. The data, used mainly for research purposes within the scientific collaboration project between NIEP and AFTAC, are available to scientific community. The second one is a PTS portable infrasound array (I67RO) deployed for one year, starting with the end of September 2016, within a collaboration project between NIEP and PTS of the Preparatory Commission for CTBTO. This array is located in the western part of Romania, at Marisel, Cluj County, covering a 0.9 km aperture and being equipped with CEA/DAM MB2005 microbarometers and Reftek RT 130 data loggers. This joint experiment aims to contribute both to advanced understanding of infrasound sources in Central-Europe and to ARISE design study project, as an expansion of the spatial coverage of the European infrasound network. The data recorded by the three infrasound arrays deployed in Romania, during a same time interval (October - December 2016) were processed into detection arrival bulletins applying CEA/DASE PMCC algorithm embedded in DTK-GPMCC (extended CTBTO NDC-in-a-box) and WinPMCC software applications. The results were plotted and analyzed using DTK-DIVA software (extended CTBTO NDC-in-a-box), in order to assess detectability of each station, as well as the capacity of fusing detections into support of infrasound monitoring

  11. Flatiron-Erie 115kV transmission line project, Larimer, Weld and Boulder Counties, Colorado

    International Nuclear Information System (INIS)

    1993-05-01

    Western Area Power Administration (Western) proposes to uprate its existing 115-kV Flatiron-Erie transmission line. The line is located in Larimer, Weld and Boulder Counties, Colorado, and passes through the City of Longmont. The line connects Flatiron Substation and several of the substations supplying Longmont. It is a single circuit 115-kV line, 31.5 miles long, and was built in 1950-51 on a 75-foot wide right-of-way (ROW) using wood H-frame structures. Western proposes to build 27 new structures along the line, to replace or modify 45 of the existing structures and to remote 11 of them. Many of these additions and changes would involve structures that are approximately 5 to 15 feet taller than the existing ones. The existing conductors and ground wires would remain in place. The purpose of these actions would be to allow the power carrying capability of the line to be increased and to replace deteriorating/structural members. Western would be the sole participant in the proposed project. This report gives an analysis of the study area environment and the development of alternative routes. An assessment is presented of the impacts of the primary alternative routes. The environmental consequences of this project are addressed

  12. Taurine activates delayed rectifier KV channels via a metabotropic pathway in retinal neurons

    Science.gov (United States)

    Bulley, Simon; Liu, Yufei; Ripps, Harris; Shen, Wen

    2013-01-01

    Taurine is one of the most abundant amino acids in the retina, throughout the CNS, and in heart and muscle cells. In keeping with its broad tissue distribution, taurine serves as a modulator of numerous basic processes, such as enzyme activity, cell development, myocardial function and cytoprotection. Despite this multitude of functional roles, the precise mechanism underlying taurine's actions has not yet been identified. In this study we report findings that indicate a novel role for taurine in the regulation of voltage-gated delayed rectifier potassium (KV) channels in retinal neurons by means of a metabotropic receptor pathway. The metabotropic taurine response was insensitive to the Cl− channel blockers, picrotoxin and strychnine, but it was inhibited by a specific serotonin 5-HT2A receptor antagonist, MDL11939. Moreover, we found that taurine enhanced KV channels via intracellular protein kinase C-mediated pathways. When 5-HT2A receptors were expressed in human embryonic kidney cells, taurine and AL34662, a non-specific 5-HT2 receptor activator, produced a similar regulation of KIR channels. In sum, this study provides new evidence that taurine activates a serotonin system, apparently via 5-HT2A receptors and related intracellular pathways. PMID:23045337

  13. Development of neural network model of the multiparametric ...

    African Journals Online (AJOL)

    The best structure of the model was established for identifying a complex multiparameter object, using the example of statistics for the operation of a ball mill.It was a network with three hidden layers and 50, 35 and 25 neurons in them, with activation functions, respectively by layers - hyperbolic tangent, sigmoid function in 2 ...

  14. Social Networking: Developing Intercultural Competence and Fostering Autonomous Learning

    Science.gov (United States)

    Vurdien, Ruby

    2014-01-01

    With the emergence of Web 2.0, the incorporation of internet-based social networking tools is becoming increasingly popular in the foreign language classes of today. This form of social interaction provides students with the opportunity to express and share their views with their peers, and to create profiles as well as online communities of…

  15. The Canarian Seismic Monitoring Network: design, development and first result

    Science.gov (United States)

    D'Auria, Luca; Barrancos, José; Padilla, Germán D.; García-Hernández, Rubén; Pérez, Aaron; Pérez, Nemesio M.

    2017-04-01

    Tenerife is an active volcanic island which experienced several eruptions of moderate intensity in historical times, and few explosive eruptions in the Holocene. The increasing population density and the consistent number of tourists are constantly raising the volcanic risk. In June 2016 Instituto Volcanologico de Canarias started the deployment of a seismological volcano monitoring network consisting of 15 broadband seismic stations. The network began its full operativity in November 2016. The aim of the network are both volcano monitoring and scientific research. Currently data are continuously recorded and processed in real-time. Seismograms, hypocentral parameters, statistical informations about the seismicity and other data are published on a web page. We show the technical characteristics of the network and an estimate of its detection threshold and earthquake location performances. Furthermore we present other near-real time procedures on the data: analysis of the ambient noise for determining the shallow velocity model and temporal velocity variations, detection of earthquake multiplets through massive data mining of the seismograms and automatic relocation of events through double-difference location.

  16. Creation, organizing and development of the French nuclear documentation network

    International Nuclear Information System (INIS)

    Vergnes, Gisele; Cheron, Christiane; Guilloux, Raymond

    1974-01-01

    This historical account covers the creation of the French nuclear documentation network, the preliminary research, aims, structures and first accomplishments of the Association Francaise de Documentation et d'Information Nucleaire (AFDIN) (French Association of Nuclear Documentation and Information) and its relations with the international system INIS [fr

  17. WORKING TOGETHER: EDUCATION, RESEARCH AND DEVELOPMENT FOR 5G NETWORKS

    Directory of Open Access Journals (Sweden)

    E. P. Ivanova

    2015-12-01

    Full Text Available In the new world of globalization of ideas and mobility difficulties in knowledge diffusion still remains. The effectiveexchange of experiences and skills in new generation networks is not guaranteed by the enormous potentialsofinternetworking systems and devices. Conceptual model for performance modeling and evaluation of multiservicenetworks has been major interest for mobile networks providers. It is essential to assess the performance ofmobile system architectures in order to identify where potential bottlenecks and data packet blocking probabilityare possible to occur. Educational platforms, new simulations opportunities represent a good opportunity to reducethe digital divide and to ensure faster and higher communication trends. Several universities and companies arecurrently involved in using educational platforms to provide better results. Conceptual model for teletrafficengineering in educational platform and applications focuses on some important aspects: tutorials, exercise,simulations, and expectation values of parameters, testing and estimation of students work. In the same time thesame model is very appropriate for simulation of network management for the new generation networks. Thiseducational platform for academics, students and researchers, puts together some of the critical aspects ofdistributed systems and their characteristics, parameters and probability of blocking.

  18. design of government cloud network for a developing economy

    African Journals Online (AJOL)

    This paper presents the design of a Government Cloud (G-Cloud) network for Ondo State Government which will provide Infrastructure as a Service (IaaS) and Software as Service (SaaS) to major government establishments and citizens within Ondo State. In designing the G-Cloud a mathematical model of cloud computing ...

  19. Networking in the Workplace: Implications for Women's Career Development

    Science.gov (United States)

    Wang, Jia

    2009-01-01

    Although the value of social capital for organization and individual career success is widely recognized, gender as a moderator in the building of social capital in organizational settings has not received adequate research attention. This chapter looks at how professional women use one aspect of social capital--networks--to assist with their…

  20. Rules of origin and development of regional production network in ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Simpler Rules of Origin (RoO) with product specific rules can act as a catalyst in trade even if tariff rates are not low. Sector specific restrictiveness across trade agreements are assessed, in view of potential growth of International production networks (IPN). RoO is shown to play a significant role in promoting IPN.

  1. A social network model for the development of a 'Theory of Mind'

    Science.gov (United States)

    Harré, Michael S.

    2013-02-01

    A "Theory of Mind" is one of the most important skills we as humans have developed; It enables us to infer the mental states and intentions of others, build stable networks of relationships and it plays a central role in our psychological make-up and development. Findings published earlier this year have also shown that we as a species as well as each of us individually benefit from the enlargement of the underlying neuro-anatomical regions that support our social networks, mediated by our Theory of Mind that stabilises these networks. On the basis of such progress and that of earlier work, this paper draws together several different strands from psychology, behavioural economics and network theory in order to generate a novel theoretical representation of the development of our social-cognition and how subsequent larger social networks enables much of our cultural development but at the increased risk of mental disorders.

  2. The Role of Adolescent Development in Social Networking Site Use: Theory and Evidence

    Directory of Open Access Journals (Sweden)

    Drew P. Cingel

    2014-03-01

    Full Text Available Using survey data collected from 260 children, adolescents, and young adults between the ages of 9 and 26, this paper offers evidence for a relationship between social networking site use and Imaginary Audience, a developmental variable in which adolescents believe others are thinking about them at all times. Specifically, after controlling for a number of variables, results indicate a significant, positive relationship between social networking site use and Imaginary Audience ideation. Additionally, results indicate a positive relationship between Imaginary Audience ideation and Facebook customization practices. Together, these findings provide evidence, based on Vygotskian developmental theory, for a general consideration of the role that currently available tools, in this case social networking sites, can have on development. Thus, findings implicate both the role of development on social networking site use, as well as the role of social networking site use on development. Overall, these findings have important implications for the study of media and human development, which are discussed in detail.

  3. Development scheme for the public electricity transport network - 2006-2020

    International Nuclear Information System (INIS)

    2006-01-01

    After having discussed the role of the development scheme and its mains requirements, presented its important components (energy needs, energy transport needs), and described its elaboration mode, this report gives an overview of the present status of the electricity transport network in France: 400.000 volts transport and interconnection networks, 225.000 volts and high voltage networks, development objectives, development context, transport network characteristics in 2006 (country gridding, development dynamics and consumption growth). Then, it presents a set of hypotheses about consumption, production and European exchanges. It identifies different types of constraints (customer connection, supply safety, electric and economic performance, robustness against extreme climate phenomena) and presents a method to assess these constraints (simulation of situations at risk, supply quality analysis, works expertise). The last part present the middle- and long-term constraints for the network

  4. Trans-European transport networks influence on the regional development and urban systems: Serbian experience

    OpenAIRE

    Maksin-Mićić Marija

    2004-01-01

    The trans-European transport network has different effects at macro-regional, mezzo-regional and micro-regional level, and on urban systems development, and its effectiveness rises at the lower regional levels. Possible approaches to the trans-European transport network impact and effect survey and policy options have been pointed out. The importance of increased accessibility and mobility for regional expansion and for more balanced and polycentric system of city networks has been underlined...

  5. A Network Approach for Distinguishing Ethical Issues in Research and Development

    OpenAIRE

    Zwart, S.D.; Van de Poel, I.; Van Mil, H.; Brumsen, M.

    2006-01-01

    In this paper we report on our experiences with using network analysis to discern and analyse ethical issues in research into, and the development of, a new wastewater treatment technology. Using network analysis, we preliminarily interpreted some of our observations in a Group Decision Room (GDR) session where we invited important stakeholders to think about the risks of this new technology. We show how a network approach is useful for understanding the observations, and suggests some releva...

  6. Reverse-engineering of gene networks for regulating early blood development from single-cell measurements.

    Science.gov (United States)

    Wei, Jiangyong; Hu, Xiaohua; Zou, Xiufen; Tian, Tianhai

    2017-12-28

    Recent advances in omics technologies have raised great opportunities to study large-scale regulatory networks inside the cell. In addition, single-cell experiments have measured the gene and protein activities in a large number of cells under the same experimental conditions. However, a significant challenge in computational biology and bioinformatics is how to derive quantitative information from the single-cell observations and how to develop sophisticated mathematical models to describe the dynamic properties of regulatory networks using the derived quantitative information. This work designs an integrated approach to reverse-engineer gene networks for regulating early blood development based on singel-cell experimental observations. The wanderlust algorithm is initially used to develop the pseudo-trajectory for the activities of a number of genes. Since the gene expression data in the developed pseudo-trajectory show large fluctuations, we then use Gaussian process regression methods to smooth the gene express data in order to obtain pseudo-trajectories with much less fluctuations. The proposed integrated framework consists of both bioinformatics algorithms to reconstruct the regulatory network and mathematical models using differential equations to describe the dynamics of gene expression. The developed approach is applied to study the network regulating early blood cell development. A graphic model is constructed for a regulatory network with forty genes and a dynamic model using differential equations is developed for a network of nine genes. Numerical results suggests that the proposed model is able to match experimental data very well. We also examine the networks with more regulatory relations and numerical results show that more regulations may exist. We test the possibility of auto-regulation but numerical simulations do not support the positive auto-regulation. In addition, robustness is used as an importantly additional criterion to select candidate

  7. Development of the carapacial ridge: implications for the evolution of genetic networks in turtle shell development.

    Science.gov (United States)

    Moustakas, Jacqueline E

    2008-01-01

    Paleontologists and neontologists have long looked to development to understand the homologies of the dermal bones that form the "armor" of turtles, crocodiles, armadillos, and other vertebrates. This study shows molecular evidence supporting a dermomyotomal identity for the mesenchyme of the turtle carapacial ridge. The mesenchyme of the carapace primordium expresses Pax3, Twist1, Dermo1, En1, Sim1, and Gremlin at early stages and before overt ossification expresses Pax1. A hypothesis is proposed that this mesenchyme forms dermal bone in the turtle carapace. A comparison of regulatory gene expression in the primordia of the turtle carapace, the vertebrate limb, and the vertebral column implies the exaptation of key genetic networks in the development of the turtle shell. This work establishes a new role for this mesodermal compartment and highlights the importance of changes in genetic regulation in the evolution of morphology.

  8. The Contribution of Network Organization and Integration to the Development of Cognitive Control.

    Science.gov (United States)

    Marek, Scott; Hwang, Kai; Foran, William; Hallquist, Michael N; Luna, Beatriz

    2015-12-01

    Cognitive control, which continues to mature throughout adolescence, is supported by the ability for well-defined organized brain networks to flexibly integrate information. However, the development of intrinsic brain network organization and its relationship to observed improvements in cognitive control are not well understood. In the present study, we used resting state functional magnetic resonance imaging (RS-fMRI), graph theory, the antisaccade task, and rigorous head motion control to characterize and relate developmental changes in network organization, connectivity strength, and integration to inhibitory control development. Subjects were 192 10-26-y-olds who were imaged during 5 min of rest. In contrast to initial studies, our results indicate that network organization is stable throughout adolescence. However, cross-network integration, predominantly of the cingulo-opercular/salience network, increased with age. Importantly, this increased integration of the cingulo-opercular/salience network significantly moderated the robust effect of age on the latency to initiate a correct inhibitory control response. These results provide compelling evidence that the transition to adult-level inhibitory control is dependent upon the refinement and strengthening of integration between specialized networks. Our findings support a novel, two-stage model of neural development, in which networks stabilize prior to adolescence and subsequently increase their integration to support the cross-domain incorporation of information processing critical for mature cognitive control.

  9. Asymmetric development of dorsal and ventral attention networks in the human brain

    Directory of Open Access Journals (Sweden)

    Kristafor Farrant

    2015-04-01

    Full Text Available Two neural systems for goal-directed and stimulus-driven attention have been described in the adult human brain; the dorsal attention network (DAN centered in the frontal eye fields (FEF and intraparietal sulcus (IPS, and the ventral attention network (VAN anchored in the temporoparietal junction (TPJ and ventral frontal cortex (VFC. Little is known regarding the processes governing typical development of these attention networks in the brain. Here we use resting state functional MRI data collected from thirty 7 to 12 year-old children and thirty 18 to 31 year-old adults to examine two key regions of interest from the dorsal and ventral attention networks. We found that for the DAN nodes (IPS and FEF, children showed greater functional connectivity with regions within the network compared with adults, whereas adults showed greater functional connectivity between the FEF and extra-network regions including the posterior cingulate cortex. For the VAN nodes (TPJ and VFC, adults showed greater functional connectivity with regions within the network compared with children. Children showed greater functional connectivity between VFC and nodes of the salience network. This asymmetric pattern of development of attention networks may be a neural signature of the shift from over-representation of bottom-up attention mechanisms to greater top-down attentional capacities with development.

  10. The Contribution of Network Organization and Integration to the Development of Cognitive Control

    Science.gov (United States)

    Marek, Scott; Hwang, Kai; Foran, William; Hallquist, Michael N.; Luna, Beatriz

    2015-01-01

    Abstract Cognitive control, which continues to mature throughout adolescence, is supported by the ability for well-defined organized brain networks to flexibly integrate information. However, the development of intrinsic brain network organization and its relationship to observed improvements in cognitive control are not well understood. In the present study, we used resting state functional magnetic resonance imaging (RS-fMRI), graph theory, the antisaccade task, and rigorous head motion control to characterize and relate developmental changes in network organization, connectivity strength, and integration to inhibitory control development. Subjects were 192 10–26-y-olds who were imaged during 5 min of rest. In contrast to initial studies, our results indicate that network organization is stable throughout adolescence. However, cross-network integration, predominantly of the cingulo-opercular/salience network, increased with age. Importantly, this increased integration of the cingulo-opercular/salience network significantly moderated the robust effect of age on the latency to initiate a correct inhibitory control response. These results provide compelling evidence that the transition to adult-level inhibitory control is dependent upon the refinement and strengthening of integration between specialized networks. Our findings support a novel, two-stage model of neural development, in which networks stabilize prior to adolescence and subsequently increase their integration to support the cross-domain incorporation of information processing critical for mature cognitive control. PMID:26713863

  11. The Contribution of Network Organization and Integration to the Development of Cognitive Control.

    Directory of Open Access Journals (Sweden)

    Scott Marek

    2015-12-01

    Full Text Available Cognitive control, which continues to mature throughout adolescence, is supported by the ability for well-defined organized brain networks to flexibly integrate information. However, the development of intrinsic brain network organization and its relationship to observed improvements in cognitive control are not well understood. In the present study, we used resting state functional magnetic resonance imaging (RS-fMRI, graph theory, the antisaccade task, and rigorous head motion control to characterize and relate developmental changes in network organization, connectivity strength, and integration to inhibitory control development. Subjects were 192 10-26-y-olds who were imaged during 5 min of rest. In contrast to initial studies, our results indicate that network organization is stable throughout adolescence. However, cross-network integration, predominantly of the cingulo-opercular/salience network, increased with age. Importantly, this increased integration of the cingulo-opercular/salience network significantly moderated the robust effect of age on the latency to initiate a correct inhibitory control response. These results provide compelling evidence that the transition to adult-level inhibitory control is dependent upon the refinement and strengthening of integration between specialized networks. Our findings support a novel, two-stage model of neural development, in which networks stabilize prior to adolescence and subsequently increase their integration to support the cross-domain incorporation of information processing critical for mature cognitive control.

  12. The C-terminal HRET sequence of Kv1.3 regulates gating rather than targeting of Kv1.3 to the plasma membrane.

    Science.gov (United States)

    Voros, Orsolya; Szilagyi, Orsolya; Balajthy, András; Somodi, Sándor; Panyi, Gyorgy; Hajdu, Péter

    2018-04-12

    Kv1.3 channels are expressed in several cell types including immune cells, such as T lymphocytes. The targeting of Kv1.3 to the plasma membrane is essential for T cell clonal expansion and assumed to be guided by the C-terminus of the channel. Using two point mutants of Kv1.3 with remarkably different features compared to the wild-type Kv1.3 (A413V and H399K having fast inactivation kinetics and tetraethylammonium-insensitivity, respectively) we showed that both Kv1.3 channel variants target to the membrane when the C-terminus was truncated right after the conserved HRET sequence and produce currents identical to those with a full-length C-terminus. The truncation before the HRET sequence (NOHRET channels) resulted in reduced membrane-targeting but non-functional phenotypes. NOHRET channels did not display gating currents, and coexpression with wild-type Kv1.3 did not rescue the NOHRET-A413V phenotype, no heteromeric current was observed. Interestingly, mutants of wild-type Kv1.3 lacking HRET(E) (deletion) or substituted with five alanines for the HRET(E) motif expressed current indistinguishable from the wild-type. These results demonstrate that the C-terminal region of Kv1.3 immediately proximal to the S6 helix is required for the activation gating and conduction, whereas the presence of the distal region of the C-terminus is not exclusively required for trafficking of Kv1.3 to the plasma membrane.

  13. Wild Horse 69-kV transmission line environmental assessment

    International Nuclear Information System (INIS)

    1996-12-01

    Hill County Electric Cooperative Inc. (Hill County) proposes to construct and operate a 69-kV transmission line from its North Gildford Substation in Montana north to the Canadian border. A vicinity project area map is enclosed as a figure. TransCanada Power Corporation (TCP), a Canadian power-marketing company, will own and construct the connecting 69-kV line from the international border to Express Pipeline's pump station at Wild Horse, Alberta. This Environmental Assessment is prepared for the Department of Energy (DOE) as lead federal agency to comply with the requirements of the National Environmental Policy Act (NEPA), as part of DOE's review and approval process of the applications filed by Hill County for a DOE Presidential Permit and License to Export Electricity to a foreign country. The purpose of the proposed line is to supply electric energy to a crude oil pump station in Canada, owned by Express Pipeline Ltd. (Express). The pipeline would transport Canadian-produced oil from Hardisty, Alberta, Canada, to Caster, Wyoming. The Express Pipeline is scheduled to be constructed in 1996--97 and will supply crude oil to refineries in Wyoming and the midwest

  14. Corona performance of a compact 230-kV line

    International Nuclear Information System (INIS)

    Chartier, V.L.; Blair, D.E.

    1994-01-01

    Permitting requirements and the acquisition of new rights-of-way for transmission facilities has in recent years become increasingly difficult for most utilities, including Puget Sound Power and Light Company. In order to maintain a high degree of reliability of service while being responsive to public concerns regarding the siting of high voltage (HV) transmission facilities, Puget Power has found it necessary to more heavily rely upon the use of compact lines in franchise corridors. Compaction does, however, precipitant increased levels of audible noise (AN) and radio and TV interference (RI and TVI) due to corona on the conductors and insulator assemblies. Puget Power relies upon the Bonneville Power Administration (BPA) Corona and Field Effects computer program to calculate AN and RI for new lines. Since there was some question of the program's ability to accurately represent quiet 230-kV compact designs, a joint project was undertaken with BPA to verify the program's algorithms. Long-term measurements made on an operating Puget Power 230-kV compact line confirmed the accuracy of BPA's AN model; however, the RI measurements were much lower than predicted by the BPA computer and other programs. This paper also describes how the BPA computer program can be used to calculate the voltage needed to expose insulator assemblies to the correct electric field in single test setups in HV laboratories

  15. A continuous acceleration tube of ions under 200 KV

    International Nuclear Information System (INIS)

    Mongodin, G.

    1954-01-01

    The realization of an Van de Graaff accelerator required, for the preliminary studies, the construction of a small proton accelerator, functioning at 200 kV in order to resolve some parasitic effects inherent to the accelerators tubes. The aim of this report is to describe the different organs of the accelerator tube, to explain the operating system and to encode their characteristics. The report first presents the ion source and the beam buncher permitting to inject in the accelerator tube particles of about 9 kV and very batched in a thin beam of circular section. Then the study explain the tube characteristics considered like optic system. A method to obtain precise calculation of particle trajectories is exposed. Aberrations of the system were discussed and balance of the currents on all electrodes inside the tube for different regimes of working were provided. The influence of the residual pressure in the tube were explained. The report finally ends on a part of the fundamental problem of the straining occurring inside the tubes accelerators under high tension. (M.B.) [fr

  16. Wild Horse 69-kV transmission line environmental assessment

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-12-01

    Hill County Electric Cooperative Inc. (Hill County) proposes to construct and operate a 69-kV transmission line from its North Gildford Substation in Montana north to the Canadian border. A vicinity project area map is enclosed as a figure. TransCanada Power Corporation (TCP), a Canadian power-marketing company, will own and construct the connecting 69-kV line from the international border to Express Pipeline`s pump station at Wild Horse, Alberta. This Environmental Assessment is prepared for the Department of Energy (DOE) as lead federal agency to comply with the requirements of the National Environmental Policy Act (NEPA), as part of DOE`s review and approval process of the applications filed by Hill County for a DOE Presidential Permit and License to Export Electricity to a foreign country. The purpose of the proposed line is to supply electric energy to a crude oil pump station in Canada, owned by Express Pipeline Ltd. (Express). The pipeline would transport Canadian-produced oil from Hardisty, Alberta, Canada, to Caster, Wyoming. The Express Pipeline is scheduled to be constructed in 1996--97 and will supply crude oil to refineries in Wyoming and the midwest.

  17. Expression and function of K(V)2-containing channels in human urinary bladder smooth muscle.

    Science.gov (United States)

    Hristov, Kiril L; Chen, Muyan; Afeli, Serge A Y; Cheng, Qiuping; Rovner, Eric S; Petkov, Georgi V

    2012-06-01

    The functional role of the voltage-gated K(+) (K(V)) channels in human detrusor smooth muscle (DSM) is largely unexplored. Here, we provide molecular, electrophysiological, and functional evidence for the expression of K(V)2.1, K(V)2.2, and the electrically silent K(V)9.3 subunits in human DSM. Stromatoxin-1 (ScTx1), a selective inhibitor of K(V)2.1, K(V)2.2, and K(V)4.2 homotetrameric channels and of K(V)2.1/9.3 heterotetrameric channels, was used to examine the role of these channels in human DSM function. Human DSM tissues were obtained during open bladder surgeries from patients without a history of overactive bladder. Freshly isolated human DSM cells were studied using RT-PCR, immunocytochemistry, live-cell Ca(2+) imaging, and the perforated whole cell patch-clamp technique. Isometric DSM tension recordings of human DSM isolated strips were conducted using tissue baths. RT-PCR experiments showed mRNA expression of K(V)2.1, K(V)2.2, and K(V)9.3 (but not K(V)4.2) channel subunits in human isolated DSM cells. K(V)2.1 and K(V)2.2 protein expression was confirmed by Western blot analysis and immunocytochemistry. Perforated whole cell patch-clamp experiments revealed that ScTx1 (100 nM) inhibited the amplitude of the voltage step-induced K(V) current in freshly isolated human DSM cells. ScTx1 (100 nM) significantly increased the intracellular Ca(2+) level in DSM cells. In human DSM isolated strips, ScTx1 (100 nM) increased the spontaneous phasic contraction amplitude and muscle force, and enhanced the amplitude of the electrical field stimulation-induced contractions within the range of 3.5-30 Hz stimulation frequencies. These findings reveal that ScTx1-sensitive K(V)2-containing channels are key regulators of human DSM excitability and contractility and may represent new targets for pharmacological or genetic intervention for bladder dysfunction.

  18. Loss Characteristics of 6.5 kV RC-IGBT Applied to a Traction Converter

    Directory of Open Access Journals (Sweden)

    Xianjin Huang

    2017-07-01

    Full Text Available 6.5 kV level IGBT (Insulated Gate Bipolar Transistor modules are widely applied in megawatt locomotive (MCUs traction converters, to achieve an upper 3.5 kV DC link, which is beneficial for decreasing power losses and increasing the power density. Reverse Conducting IGBT (RC-IGBT constructs the conventional IGBT function and freewheel diode function in a single chip, which has a greater flow ability in the same package volume. In the same cooling conditions, RC-IGBT allows for a higher operating temperature. In this paper, a mathematic model is developed, referring to the datasheets and measurement data, to study the 6.5 kV/1000 A RC-IGBT switching features. The relationship among the gate desaturated pulse, conducting losses, and recovery losses is discussed. Simulations and tests were carried out to consider the influence of total losses on the different amplitudes and durations of the desaturated pulse. The RC-IGBT traction converter system with gate pulse desaturated control is built, and the simulation and measurements show that the total losses of RC-IGBT with desaturated control decreased comparing to the RC-IGBT without desaturated control or conventional IGBT. Finally, a proportional small power platform is developed, and the test results prove the correction of the theory analysis.

  19. An Industrial Control System for the Supervision of the CERN Electrical Distribution Network

    CERN Document Server

    Poulsen, S

    1999-01-01

    CERN operates a large distribution network for the supply of electricity to the particle accelerators, experiments and the associated infrastructure. The distribution network operates on voltage levels from 400 V to 400 kV with a total yearly consumption of near to 1000 GWh. In the past, the laboratory has developed an in-house control system for this network, using the technologies applied to the accelerator control system. However, CERN is now working on a project to purchase, configure and install an industrial Electrical Network Supervisor (ENS). This is a state-of-the-art industrial control system completely developed and supported by an external contractor. The system - based on a scalable and distributed architecture - will allow the installation to be performed gradually, and will be tested while the existing system is fully operational. Ultimately, the complete electrical distribution network will be supervised with this new system, the maintenance and further development of which will be the complet...

  20. Contribution of kv7.4/kv7.5 heteromers to intrinsic and calcitonin gene-related Peptide-induced cerebral reactivity

    DEFF Research Database (Denmark)

    Chadha, Preet S; Jepps, Thomas A; Carr, Georgina

    2014-01-01

    Middle cerebral artery (MCA) diameter is regulated by inherent myogenic activity and the effect of potent vasodilators such as calcitonin gene-related peptide (CGRP). Previous studies showed that MCAs express KCNQ1, 4, and 5 potassium channel genes, and the expression products (Kv7 channels) part......) participate in the myogenic control of MCA diameter. The present study investigated the contribution of Kv7.4 and Kv7.5 isoforms to myogenic and CGRP regulation of MCA diameter and determined whether they were affected in hypertensive animals....

  1. Evolving networks and the development of neural systems

    International Nuclear Information System (INIS)

    Johnson, Samuel; Marro, J; Torres, Joaquín J

    2010-01-01

    It is now generally assumed that the heterogeneity of most networks in nature probably arises via preferential attachment of some sort. However, the origin of various other topological features, such as degree–degree correlations and related characteristics, is often not clear, and they may arise from specific functional conditions. We show how it is possible to analyse a very general scenario in which nodes can gain or lose edges according to any (e.g., nonlinear) function of local and/or global degree information. Applying our method to two rather different examples of brain development—synaptic pruning in humans and the neural network of the worm C. Elegans—we find that simple biologically motivated assumptions lead to very good agreement with experimental data. In particular, many nontrivial topological features of the worm's brain arise naturally at a critical point

  2. Social media for professional development and networking opportunities in academia

    OpenAIRE

    Donelan, Helen

    2016-01-01

    The research reported on in this article explores the use of social media for work-related or professional purposes. In particular, it focuses on the perceptions and use of social media by academics in the UK. The purpose of the research was to explore the potential social media has to facilitate the changing landscape of higher education and support the individual academic in their role. Of particular interest is how specific social media tools are being used to enhance networking opportunit...

  3. Netpixl: Towards a New Paradigm for Networked Application Development

    OpenAIRE

    Diakopoulos, Dimitri; Kapur, Ajay

    2013-01-01

    Netpixl is a new micro-toolkit built to network devices within interactiveinstallations and environments. Using a familiar client-server model, Netpixlcentrally wraps an important aspect of ubiquitous computing: real-timemessaging. In the context of sound and music computing, the role of Netpixl isto fluidly integrate endpoints like OSC and MIDI within a larger multi-usersystem. This paper considers useful design principles that may be applied totoolkits like Netpixl while also emphasizing re...

  4. The Development of Network Relations of MNC Subsidiaries : How Internal MNC and External (Local) Relations Evolve

    NARCIS (Netherlands)

    Drogendijk, H.J.

    2005-01-01

    Managing relations is a complex task for internationalizing firms and their subsidiaries: MNC subsidiaries are not only part of the MNC network but they also develop relations with network actors in their local environment.This paper investigates conceptually how MNC subsidiaries established through

  5. The Influence of Social Networking Sites on High School Students' Social and Academic Development

    Science.gov (United States)

    Ahn, June

    2010-01-01

    This dissertation examines the effects of social network sites on youth social and academic development. First, I provide a critical analysis of the extant research literature surrounding social network sites and youth. I merge scholarly thought in the areas of Internet studies, digital divides, social capital theory, psychological well-being,…

  6. Detection of silent cells, synchronization and modulatory activity in developing cellular networks.

    NARCIS (Netherlands)

    Hjorth, J.J.J.; Dawitz, J.; Kroon, T.; da Silva Dias Pires, J.H.; Dassen, V.J.; Berkhout, J.A.; Emperador Melero, J.; Nadadhur, A.G.; Alevra, M.; Toonen, R.F.G.; Heine, V.M.; Mansvelder, H.D.; Meredith, R.M.

    2016-01-01

    Developing networks in the immature nervous system and in cellular cultures are characterized by waves of synchronous activity in restricted clusters of cells. Synchronized activity in immature networks is proposed to regulate many different developmental processes, from neuron growth and cell

  7. The Development and Implementation of a Global Network for Eurasia Educational Service Using Electronic Mail.

    Science.gov (United States)

    Algee, Alan

    The purpose of this study was to choose an appropriate network provider for educational consultants and to develop and implement the network at Eurasia Educational Services (EES) using electronic mail (e-mail). The following eight steps were undertaken: literature review, scanning and selecting of provider criteria, decision-making, participant…

  8. Enhancing Lifelong Competence Development and Management Systems with Social Network-based Concepts and Tools

    NARCIS (Netherlands)

    Cheak, Alicia; Angehrn, Albert; Sloep, Peter

    2006-01-01

    This paper addresses the challenge of enhancing the social dimension of lifelong Competence Development and Management Systems with social network-based concepts and tools. Our premise is that through a combination of social network visualization tools, simulations, stimulus agents and management

  9. A network approach for distinguishing ethical issues in research and development

    NARCIS (Netherlands)

    Zwart, S.D.; Poel, van de I.R.; Mil, van H.G.J.; Brumsen, M.

    2006-01-01

    In this paper we report on our experiences with using network analysis to discern and analyse ethical issues in research into, and the development of, a new wastewater treatment technology. Using network analysis, we preliminarily interpreted some of our observations in a Group Decision Room (GDR)

  10. A Network Approach for Distinguishing Ethical Issues in Research and Development

    NARCIS (Netherlands)

    Zwart, S.D.; Van de Poel, I.; Van Mil, H.; Brumsen, M.

    2006-01-01

    In this paper we report on our experiences with using network analysis to discern and analyse ethical issues in research into, and the development of, a new wastewater treatment technology. Using network analysis, we preliminarily interpreted some of our observations in a Group Decision Room (GDR)

  11. Development and application of deep convolutional neural network in target detection

    Science.gov (United States)

    Jiang, Xiaowei; Wang, Chunping; Fu, Qiang

    2018-04-01

    With the development of big data and algorithms, deep convolution neural networks with more hidden layers have more powerful feature learning and feature expression ability than traditional machine learning methods, making artificial intelligence surpass human level in many fields. This paper first reviews the development and application of deep convolutional neural networks in the field of object detection in recent years, then briefly summarizes and ponders some existing problems in the current research, and the future development of deep convolutional neural network is prospected.

  12. Development of neural network simulating power distribution of a BWR fuel bundle

    International Nuclear Information System (INIS)

    Tanabe, A.; Yamamoto, T.; Shinfuku, K.; Nakamae, T.

    1992-01-01

    A neural network model is developed to simulate the precise nuclear physics analysis program code for quick scoping survey calculations. The relation between enrichment and local power distribution of BWR fuel bundles was learned using two layers neural network (ENET). A new model is to introduce burnable neutron absorber (Gadolinia), added to several fuel rods to decrease initial reactivity of fresh bundle. The 2nd stages three layers neural network (GNET) is added on the 1st stage network ENET. GNET studies the local distribution difference caused by Gadolinia. Using this method, it becomes possible to survey of the gradients of sigmoid functions and back propagation constants with reasonable time. Using 99 learning patterns of zero burnup, good error convergence curve is obtained after many trials. This neural network model is able to simulate no learned cases fairly as well as the learned cases. Computer time of this neural network model is about 100 times faster than a precise analysis model. (author)

  13. Initial application of a geometric QA tool for integrated MV and kV imaging systems on three image guided radiotherapy systems.

    Science.gov (United States)

    Mao, Weihua; Speiser, Michael; Medin, Paul; Papiez, Lech; Solberg, Timothy; Xing, Lei

    2011-05-01

    Several linacs with integrated kilovoltage (kV) imaging have been developed for delivery of image guided radiation therapy (IGRT). High geometric accuracy and coincidence of kV imaging systems and megavoltage (MV) beam delivery are essential for successful image guidance. A geometric QA tool has been adapted for routine QA for evaluating and characterizing the geometric accuracy of kV and MV cone-beam imaging systems. The purpose of this work is to demonstrate the application of methodology to routine QA across three IGRT-dedicated linac platforms. It has been applied to a Varian Trilogy (Varian Medical Systems, Palo Alto, CA), an Elekta SynergyS (Elekta, Stockholm, Sweden), and a Brainlab Vero (Brainlab AG, Feldkirchen, Germany). Both the Trilogy and SynergyS linacs are equipped with a retractable kV x-ray tube and a flat panel detector. The Vero utilizes a rotating, rigid ring structure integrating a MV x-ray head mounted on orthogonal gimbals, an electronic portal imaging device (EPID), two kV x-ray tubes, and two fixed flat panel detectors. This dual kV imaging system provides orthogonal radiographs, CBCT images, and real-time fluoroscopic monitoring. Two QA phantoms were built to suit different field sizes. Projection images of a QA phantom were acquired using MV and kV imaging systems at a series of gantry angles. Software developed for this study was used to analyze the projection images and calculate nine geometric parameters for each projection. The Trilogy was characterized five times over one year, while the SynergyS was characterized four times and the Vero once. Over 6500 individual projections were acquired and analyzed. Quantitative geometric parameters of both MV and kV imaging systems, as well as the isocenter consistency of the imaging systems, were successfully evaluated. A geometric tool has been successfully implemented for calibration and QA of integrated kV and MV across a variety of radiotherapy platforms. X-ray source angle deviations up to

  14. ‘Down-Stream’ Network Characteristics, Broker Functions and New Product Development Success

    DEFF Research Database (Denmark)

    Smed, Marie; Salomo, Søren; Li, Ying

    2011-01-01

    that small entrepreneurial start up company’s supply knowledge to network alliances with well-established and financially strong companies. However, in the later stages of development the main influence of external partnerships is described as financial support and joining distribution efforts, rather than...... of later stage product development tasks. While networks can be characterized by a number of measures like breadth, density, and structural characteristics, more recent developments in network and alliance management need to be specifically accounted for. In particular, it is observed that companies today...... richness to our conceptual model, we further include qualitative case studies supporting grounded theory building. In sum, this paper contributes to the literature by the following: (1) We develop a systematic overview over network characteristics shown to have impact for new product development. (2) We...

  15. Active local distribution network management for embedded generation

    Energy Technology Data Exchange (ETDEWEB)

    White, S.

    2005-07-01

    With the newer electric power transmission networks, there is a requirement for power to flow in two different directions and this calls for more intelligent forms of management. To satisfy these demands, GENEVAC has produced a controller that aims to increase the energy that power plants can feed to the distribution networks. The software and hardware have undergone trials at two 33/11 kV substations in England. The hardware was designed to monitor voltage, current and phase angle at various points in the network. The software estimates the value of the voltages at every node in the network. The results showed good correlation between estimated and measured voltages: other findings are reported. Recommendations for further work are made including development of a full commercial system. The study was conducted by Econnect Ltd under contract to the DTI.

  16. The pan-Kv7 (KCNQ) Channel Opener Retigabine Inhibits Striatal Excitability by Direct Action on Striatal Neurons In Vivo

    DEFF Research Database (Denmark)

    Hansen, Henrik H; Weikop, Pia; Mikkelsen, Maria D

    2017-01-01

    Central Kv7 (KCNQ) channels are voltage-dependent potassium channels composed of different combinations of four Kv7 subunits, being differently expressed in the brain. Notably, striatal dopaminergic neurotransmission is strongly suppressed by systemic administration of the pan-Kv7 channel opener ...... by acute systemic haloperidol administration in the rat. The relative mRNA levels of Kv7 subunits in the rat striatum were found to be Kv7.2 = Kv7.3 = Kv7.5 > >Kv7.4. These data suggest that intrastriatal Kv7 channels play a direct role in regulating striatal excitability in vivo....

  17. High power cable with internal water cooling 400 kV

    Science.gov (United States)

    Rasquin, W.; Harjes, B.

    1982-08-01

    Due to the concentration of electricity production in large power plants, the need of higher power transmissions, and the protection of environment, developement of a 400 kV water cooled cable in the power range of 1 to 5 GVA was undertaken. The fabrication and testing of equipment, engineering of cable components, fabrication of a test cable, development of cable terminal laboratory, testing of test cable, field testing of test cable, fabrication of industrial cable laboratory, testing of industrial cable, field testing of industrial cable, and system analysis for optimization were prepared. The field testing was impossible to realize. However, it is proved that a cable consisting of an internal stainless steel water cooled tube, covered by stranded copper profiles, insulated with heavy high quality paper, and protected by an aluminum cover can be produced, withstand tests accordingly to IEC/VDE recommendations, and is able to fulfill all exploitation conditions.

  18. A 70 kV solid-state high voltage pulse generator based on saturable pulse transformer.

    Science.gov (United States)

    Fan, Xuliang; Liu, Jinliang

    2014-02-01

    High voltage pulse generators are widely applied in many fields. In recent years, solid-state and operating at repetitive mode are the most important developing trends of high voltage pulse generators. A solid-state high voltage pulse generator based on saturable pulse transformer is proposed in this paper. The proposed generator is consisted of three parts. They are charging system, triggering system, and the major loop. Saturable pulse transformer is the key component of the whole generator, which acts as a step-up transformer and main switch during working process of this generator. The circuit and working principles of the proposed pulse generator are introduced first in this paper, and the saturable pulse transformer used in this generator is introduced in detail. Circuit of the major loop is simulated to verify the design of the system. Demonstration experiments are carried out, and the results show that when the primary energy storage capacitor is charged to a high voltage, such as 2.5 kV, a voltage with amplitude of 86 kV can be achieved on the secondary winding. The magnetic core of saturable pulse transformer is saturated deeply and the saturable inductance of the secondary windings is very small. The switch function of the saturable pulse transformer can be realized ideally. Therefore, a 71 kV output voltage pulse is formed on the load. Moreover, the magnetic core of the saturable pulse transformer can be reset automatically.

  19. Conceptual Framework for Developing a Diabetes Information Network.

    Science.gov (United States)

    Riazi, Hossein; Langarizadeh, Mostafa; Larijani, Bagher; Shahmoradi, Leila

    2016-06-01

    To provide a conceptual framework for managing diabetic patient care, and creating an information network for clinical research. A wide range of information technology (IT) based interventions such as distance learning, diabetes registries, personal or electronic health record systems, clinical information systems, and clinical decision support systems have so far been used in supporting diabetic care. Previous studies demonstrated that IT could improve diabetes care at its different aspects. There is however no comprehensive conceptual framework that defines how different IT applications can support diverse aspects of this care. Therefore, a conceptual framework that combines different IT solutions into a wide information network for improving care processes and for research purposes is widely lacking. In this study we describe the theoretical underpin of a big project aiming at building a wide diabetic information network namely DIANET. A literature review and a survey of national programs and existing regulations for diabetes management was conducted in order to define different aspects of diabetic care that should be supported by IT solutions. Both qualitative and quantitative research methods were used in this study. In addition to the results of a previous systematic literature review, two brainstorming and three expert panel sessions were conducted to identify requirements of a comprehensive information technology solution. Based on these inputs, the requirements for creating a diabetes information network were identified and used to create a questionnaire based on 9-point Likert scale. The questionnaire was finalized after removing some items based on calculated content validity ratio and content validity index coefficients. Cronbach's alpha reliability coefficient was also calculated (αTotal= 0.98, Pconceptual framework. The questionnaires were returned by 10 clinicians. Each requirement item was labeled as essential, semi-essential, or non

  20. 400 kV injector compact ECR ion source

    International Nuclear Information System (INIS)

    Constantin, F.; Catana, D.; Macovei, M.; Ivanov, E.

    1997-01-01

    Obtaining multiple ionised ions is a fundamental problem for some applications and research. Multiple ionised ions can be produced from electronic bombardment, when n·τ≥5·10 9 cm -3 · s, where n is the density of electrons (in cm -3 ) and τ is the time of interaction between electrons and ions . The relative speed of electrons and ions determines the equilibrium between the stripping process of the atom's electrons and their capture. An ion source with high ionisation efficiency and large output current is the ECR source (Electron Cyclotron Resonance). Using an ECR source with permanent magnets as ion source for the injector will lead to following advantages: - the possibility to obtain multiple ionised particles; - an increase of ion beam intensities; - the expanding of accelerator activities; - a longer working time, due to magnetron lifetime. The ECR ion source is robust, compact and capable of high intensities of extracted ion current. The large functional domain for the residual gas pressure allows the production of multiple charged ions. The source can be easily integrated in the TRILAC's injection structure. We realised a compact microwave ion source which has an axial magnetic field generated by a permanent magnet of Co-Sm. 1200 G magnetic field is greater than the 875 G magnetic field corresponding to the electron-cyclotron frequency of 2.45 GHz. The microwave generator is a magnetron (2.45 GHz and 200 W in continuos wave). The microwave is fed through a coaxial connector on the top of flange. The test was made on He gas at a pressure between 8· 10 -4 and 5·10 -2 torr. The ion beam current was measured vs. extracted potential from 3 kV to 10 kV and has a dependence according to U 3/2 law. A maximal ion current of 300 μA at 10 kV extraction potential was measured. Dimension of ECR ion source, including Einzel lens are φ=12 cm and h=16 cm. (authors)

  1. Note: Design and development of wireless controlled aerosol sampling network for large scale aerosol dispersion experiments

    International Nuclear Information System (INIS)

    Gopalakrishnan, V.; Subramanian, V.; Baskaran, R.; Venkatraman, B.

    2015-01-01

    Wireless based custom built aerosol sampling network is designed, developed, and implemented for environmental aerosol sampling. These aerosol sampling systems are used in field measurement campaign, in which sodium aerosol dispersion experiments have been conducted as a part of environmental impact studies related to sodium cooled fast reactor. The sampling network contains 40 aerosol sampling units and each contains custom built sampling head and the wireless control networking designed with Programmable System on Chip (PSoC™) and Xbee Pro RF modules. The base station control is designed using graphical programming language LabView. The sampling network is programmed to operate in a preset time and the running status of the samplers in the network is visualized from the base station. The system is developed in such a way that it can be used for any other environment sampling system deployed in wide area and uneven terrain where manual operation is difficult due to the requirement of simultaneous operation and status logging

  2. Note: Design and development of wireless controlled aerosol sampling network for large scale aerosol dispersion experiments

    Energy Technology Data Exchange (ETDEWEB)

    Gopalakrishnan, V.; Subramanian, V.; Baskaran, R.; Venkatraman, B. [Radiation Impact Assessment Section, Radiological Safety Division, Indira Gandhi Centre for Atomic Research, Kalpakkam 603 102 (India)

    2015-07-15

    Wireless based custom built aerosol sampling network is designed, developed, and implemented for environmental aerosol sampling. These aerosol sampling systems are used in field measurement campaign, in which sodium aerosol dispersion experiments have been conducted as a part of environmental impact studies related to sodium cooled fast reactor. The sampling network contains 40 aerosol sampling units and each contains custom built sampling head and the wireless control networking designed with Programmable System on Chip (PSoC™) and Xbee Pro RF modules. The base station control is designed using graphical programming language LabView. The sampling network is programmed to operate in a preset time and the running status of the samplers in the network is visualized from the base station. The system is developed in such a way that it can be used for any other environment sampling system deployed in wide area and uneven terrain where manual operation is difficult due to the requirement of simultaneous operation and status logging.

  3. A network approach for distinguishing ethical issues in research and development.

    Science.gov (United States)

    Zwart, Sjoerd D; van de Poel, Ibo; van Mil, Harald; Brumsen, Michiel

    2006-10-01

    In this paper we report on our experiences with using network analysis to discern and analyse ethical issues in research into, and the development of, a new wastewater treatment technology. Using network analysis, we preliminarily interpreted some of our observations in a Group Decision Room (GDR) session where we invited important stakeholders to think about the risks of this new technology. We show how a network approach is useful for understanding the observations, and suggests some relevant ethical issues. We argue that a network approach is also useful for ethical analysis of issues in other fields of research and development. The abandoning of the overarching rationality assumption, which is central to network approaches, does not have to lead to ethical relativism.

  4. Networking

    OpenAIRE

    Rauno Lindholm, Daniel; Boisen Devantier, Lykke; Nyborg, Karoline Lykke; Høgsbro, Andreas; Fries, de; Skovlund, Louise

    2016-01-01

    The purpose of this project was to examine what influencing factor that has had an impact on the presumed increasement of the use of networking among academics on the labour market and how it is expressed. On the basis of the influence from globalization on the labour market it can be concluded that the globalization has transformed the labour market into a market based on the organization of networks. In this new organization there is a greater emphasis on employees having social qualificati...

  5. Model-Driven Approach for Body Area Network Application Development.

    Science.gov (United States)

    Venčkauskas, Algimantas; Štuikys, Vytautas; Jusas, Nerijus; Burbaitė, Renata

    2016-05-12

    This paper introduces the sensor-networked IoT model as a prototype to support the design of Body Area Network (BAN) applications for healthcare. Using the model, we analyze the synergistic effect of the functional requirements (data collection from the human body and transferring it to the top level) and non-functional requirements (trade-offs between energy-security-environmental factors, treated as Quality-of-Service (QoS)). We use feature models to represent the requirements at the earliest stage for the analysis and describe a model-driven methodology to design the possible BAN applications. Firstly, we specify the requirements as the problem domain (PD) variability model for the BAN applications. Next, we introduce the generative technology (meta-programming as the solution domain (SD)) and the mapping procedure to map the PD feature-based variability model onto the SD feature model. Finally, we create an executable meta-specification that represents the BAN functionality to describe the variability of the problem domain though transformations. The meta-specification (along with the meta-language processor) is a software generator for multiple BAN-oriented applications. We validate the methodology with experiments and a case study to generate a family of programs for the BAN sensor controllers. This enables to obtain the adequate measure of QoS efficiently through the interactive adjustment of the meta-parameter values and re-generation process for the concrete BAN application.

  6. Development of electrochemical supercapacitors with uniform nanoporous silver network

    International Nuclear Information System (INIS)

    Li, Rui; Liu, Xiongjun; Wang, Hui; Wu, Yuan; Lu, Z.P.

    2015-01-01

    Metal oxides such as manganese dioxide (MnO 2 ) are often used as electrode materials for supercapacitors due to their high specific capacitance. In practice, however, their specific capacitance is much smaller than the theoretical limit due to the low electrical conductivity and serious agglomeration. In the present work, we demonstrate that highly conductive nanoporous silver (NPS) network with uniform continuous nanoporosity and high surface area which was fabricated by dealloying Ag-Mg-Ca metallic glasses can be employed as supports and collectors for MnO 2 capacitors. By plating the MnO 2 nanocrystals into the nanopore structure, the NPS/MnO 2 composite electrode provides fast ionic conduction and excellent electron-proton transport, resulting in an ultrahigh specific capacitance of the plated active MnO 2 (∼1088 F g −1 ), which is close to the theoretical limit. The unique combination of high specific capacitance and long cycle life enhanced by the current composite structure makes the NPS/MnO 2 composite promising for electrochemical supercapacitor as electrode material. In addition, our findings suggest that the uniform NPS network is capable for improving capacitance performance of metal oxides in electrochemical supercapacitors.

  7. Model-Driven Approach for Body Area Network Application Development

    Science.gov (United States)

    Venčkauskas, Algimantas; Štuikys, Vytautas; Jusas, Nerijus; Burbaitė, Renata

    2016-01-01

    This paper introduces the sensor-networked IoT model as a prototype to support the design of Body Area Network (BAN) applications for healthcare. Using the model, we analyze the synergistic effect of the functional requirements (data collection from the human body and transferring it to the top level) and non-functional requirements (trade-offs between energy-security-environmental factors, treated as Quality-of-Service (QoS)). We use feature models to represent the requirements at the earliest stage for the analysis and describe a model-driven methodology to design the possible BAN applications. Firstly, we specify the requirements as the problem domain (PD) variability model for the BAN applications. Next, we introduce the generative technology (meta-programming as the solution domain (SD)) and the mapping procedure to map the PD feature-based variability model onto the SD feature model. Finally, we create an executable meta-specification that represents the BAN functionality to describe the variability of the problem domain though transformations. The meta-specification (along with the meta-language processor) is a software generator for multiple BAN-oriented applications. We validate the methodology with experiments and a case study to generate a family of programs for the BAN sensor controllers. This enables to obtain the adequate measure of QoS efficiently through the interactive adjustment of the meta-parameter values and re-generation process for the concrete BAN application. PMID:27187394

  8. The AMES network strategy developments within and outside the EU

    International Nuclear Information System (INIS)

    Sevini, F.; Debarberis, L.; Davies, L.M.; English, C.

    2001-01-01

    The AMES (Ageing Materials Evaluation and Studies) network started its activity in 1993 with the aim of studying the consequences and the mechanisms of the ageing process in materials used for nuclear reactor components. Together with ENIQ, NESC, EPERC, it forms the so-called ''Structural Integrity of Industrial Components'' cluster of networks operated by the Joint Research Centre - Institute for Advanced Materials of the European Commission. After two initial phases dedicated to the compilation of state-of-the-art reports on non-destructive monitoring techniques for thermal ageing, dosimetry, survey of regulatory requirements, predictive formulas for irradiation embrittlement, AMES has entered its third strategy phase with the fifth EURATOM Framework Program, Nuclear Fission Safety Key Action. Most of the projects proposed for this program and sustained by the Steering committee were selected for funding. Their focus is on the influence of chemical composition, namely phosphorus and nickel content, on the irradiation embrittlement of reactor pressure vessel materials, on the improvement of surveillance temperature measurement, on the validation of the Master Curve approach, and on ND techniques to monitor ageing of irradiated steels. The paper describes the objectives of the new fifth Framework Program projects and how they are part of the AMES strategy, pointing out the involvement of CEEC and NIS countries. (authors)

  9. Recent developments in research on catalytic reaction networks

    Directory of Open Access Journals (Sweden)

    Roberto Serra

    2013-09-01

    Full Text Available Over the last years, analyses performed on a stochastic model of catalytic reaction networks have provided some indications about the reasons why wet-lab experiments hardly ever comply with the phase transition typically predicted by theoretical models with regard to the emergence of collectively self-replicating sets of molecule (also defined as autocatalytic sets, ACSs, a phenomenon that is often observed in nature and that is supposed to have played a major role in the emergence of the primitive forms of life. The model at issue has allowed to reveal that the emerging ACSs are characterized by a general dynamical fragility, which might explain the difficulty to observe them in lab experiments. In this work, the main results of the various analyses are reviewed, with particular regard to the factors able to affect the generic properties of catalytic reactions network, for what concerns, not only the probability of ACSs to be observed, but also the overall activity of the system, in terms of production of new species, reactions and matter.

  10. Model-Driven Approach for Body Area Network Application Development

    Directory of Open Access Journals (Sweden)

    Algimantas Venčkauskas

    2016-05-01

    Full Text Available This paper introduces the sensor-networked IoT model as a prototype to support the design of Body Area Network (BAN applications for healthcare. Using the model, we analyze the synergistic effect of the functional requirements (data collection from the human body and transferring it to the top level and non-functional requirements (trade-offs between energy-security-environmental factors, treated as Quality-of-Service (QoS. We use feature models to represent the requirements at the earliest stage for the analysis and describe a model-driven methodology to design the possible BAN applications. Firstly, we specify the requirements as the problem domain (PD variability model for the BAN applications. Next, we introduce the generative technology (meta-programming as the solution domain (SD and the mapping procedure to map the PD feature-based variability model onto the SD feature model. Finally, we create an executable meta-specification that represents the BAN functionality to describe the variability of the problem domain though transformations. The meta-specification (along with the meta-language processor is a software generator for multiple BAN-oriented applications. We validate the methodology with experiments and a case study to generate a family of programs for the BAN sensor controllers. This enables to obtain the adequate measure of QoS efficiently through the interactive adjustment of the meta-parameter values and re-generation process for the concrete BAN application.

  11. Time development in the early history of social networks: link stabilization, group dynamics, and segregation.

    Science.gov (United States)

    Bruun, Jesper; Bearden, Ian G

    2014-01-01

    Studies of the time development of empirical networks usually investigate late stages where lasting connections have already stabilized. Empirical data on early network history are rare but needed for a better understanding of how social network topology develops in real life. Studying students who are beginning their studies at a university with no or few prior connections to each other offers a unique opportunity to investigate the formation and early development of link patterns and community structure in social networks. During a nine week introductory physics course, first year physics students were asked to identify those with whom they communicated about problem solving in physics during the preceding week. We use these students' self reports to produce time dependent student interaction networks. We investigate these networks to elucidate possible effects of different student attributes in early network formation. Changes in the weekly number of links show that while roughly half of all links change from week to week, students also reestablish a growing number of links as they progress through their first weeks of study. Using the Infomap community detection algorithm, we show that the networks exhibit community structure, and we use non-network student attributes, such as gender and end-of-course grade to characterize communities during their formation. Specifically, we develop a segregation measure and show that students structure themselves according to gender and pre-organized sections (in which students engage in problem solving and laboratory work), but not according to end-of-coure grade. Alluvial diagrams of consecutive weeks' communities show that while student movement between groups are erratic in the beginning of their studies, they stabilize somewhat towards the end of the course. Taken together, the analyses imply that student interaction networks stabilize quickly and that students establish collaborations based on who is immediately

  12. Networking and Information Technology Research and Development. Supplement of the President's Budget for Fiscal Year 2006

    National Research Council Canada - National Science Library

    2005-01-01

    This Supplement to the President's Budget for Fiscal Year 2006 offers a brief technical outline of the 2006 budget request for the Networking and Information Technology Research and Development (NITRD) Program...

  13. Grand Challenges: Science, Engineering, and Societal Advances, Requiring Networking and Information Technology Research and Development

    Data.gov (United States)

    Networking and Information Technology Research and Development, Executive Office of the President — ...the U.S. Government makes critical decisions about appropriate investments in IT R and D to help society forward both socially and economically. To inform that...

  14. Concept development and needs identification for intelligent network flow optimization (INFLO) : concept of operations.

    Science.gov (United States)

    2012-06-01

    The purpose of this project is to develop for the Intelligent Network Flow Optimization (INFLO), which is one collection (or bundle) of high-priority transformative applications identified by the United States Department of Transportation (USDOT) Mob...

  15. Concept development and needs identification for intelligent network flow optimization (INFLO) : test readiness assessment.

    Science.gov (United States)

    2012-11-01

    The purpose of this project is to develop for the Intelligent Network Flow Optimization (INFLO), which is one collection (or bundle) of high-priority transformative applications identified by the United States Department of Transportation (USDOT) Mob...

  16. A Newly Developed Method for Computing Reliability Measures in a Water Supply Network

    Directory of Open Access Journals (Sweden)

    Jacek Malinowski

    2016-01-01

    Full Text Available A reliability model of a water supply network has beens examined. Its main features are: a topology that can be decomposed by the so-called state factorization into a (relativelysmall number of derivative networks, each having a series-parallel structure (1, binary-state components (either operative or failed with given flow capacities (2, a multi-state character of the whole network and its sub-networks - a network state is defined as the maximal flow between a source (sources and a sink (sinks (3, all capacities (component, network, and sub-network have integer values (4. As the network operates, its state changes due to component failures, repairs, and replacements. A newly developed method of computing the inter-state transition intensities has been presented. It is based on the so-called state factorization and series-parallel aggregation. The analysis of these intensities shows that the failure-repair process of the considered system is an asymptotically homogenous Markov process. It is also demonstrated how certain reliability parameters useful for the network maintenance planning can be determined on the basis of the asymptotic intensities. For better understanding of the presented method, an illustrative example is given. (original abstract

  17. Problems of organization and development of the Latvian energy efficiency network

    International Nuclear Information System (INIS)

    Petrov, B.; Puikevica-Puikevska, I.

    1999-01-01

    The idea to create an Energy Efficiency Network (Network) was put forward in Canada. In 1989 similar activities started in Norway. Taking account the difficult economical situation in the Latvia industry, such a Network would help to develop our enterprises under conditions of competition. In the future, this Network is to ensure a stabile operation of the international level. Therefore Network's purposes are: to promote decision-making process with due account for the energy efficiency measures and environment-friendly energy use in industry; to encourage reducing the specific consumption of energy; to promote the information exchange among industrial enterprises as well as with new technology suppliers, and service and consulting enterprises. The task of Network is to process information on the activities of enterprises, to perform computations and to show the condition of every enterprise in the same branch of industry, by means of diagrams and tables, as well as to reveal weak points of the enterprise. The benefits of the Network participants: Network information data base allows the participants to compare their energy efficiency data with those of other enterprises in the same branch of industry; opportunity to receive information on the newest achievements in the energy efficiency measures; opportunity to familiarise themselves with the necessary project documentation, reports, ets. Network's activities are organised due consideration for particular needs of an enterprise reported directly by the participants of the enterprise. (author)

  18. Requirements of the integration of renewable energy into network charge regulation. Proposals for the further development of the network charge system. Final report

    International Nuclear Information System (INIS)

    Friedrichsen, Nele; Klobasa, Marian; Marwitz, Simon; Hilpert, Johannes; Sailer, Frank

    2016-01-01

    In this project we analyzed options to advance the network tariff system to support the German energy transition. A power system with high shares of renewables, requires more flexibility of supply and demand than the traditional system based on centralized, fossil power plants. Further, the power networks need to be adjusted and expanded. The transformation should aim at system efficiency i.e. look at both generation and network development. Network tariffs allocate the network cost towards network users. They also should provide incentives, e.g. to reduce peak load in periods of network congestion. Inappropriate network tariffs can hinder the provision of flexibility and thereby become a barrier towards system integration of renewable. Against this background, this report presents a systematic review of the German network tariff system and a discussion of several options to adapt the network tarif system in order to support the energy transition. The following aspects are analyzed: An adjustment of the privileges for industrial users to increase potential network benefits and reduce barriers towards a more market oriented behaviour. The payments for avoided network charges to distributed generation, that do not reflect cost reality in distribution networks anymore. Uniform transmission network tariffs as an option for a more appropriate allocation of cost associated with the energy transition. Increased standing fees in low voltage networks as an option to increase the cost-contribution of users with self-generation to network financing. Generator tariffs, to allocate a share of network cost to generators and provide incentives for network oriented location choice and/or feed-in.

  19. Modelling Inter-relationships among water, governance, human development variables in developing countries with Bayesian networks.

    Science.gov (United States)

    Dondeynaz, C.; Lopez-Puga, J.; Carmona-Moreno, C.

    2012-04-01

    Improving Water and Sanitation Services (WSS), being a complex and interdisciplinary issue, passes through collaboration and coordination of different sectors (environment, health, economic activities, governance, and international cooperation). This inter-dependency has been recognised with the adoption of the "Integrated Water Resources Management" principles that push for the integration of these various dimensions involved in WSS delivery to ensure an efficient and sustainable management. The understanding of these interrelations appears as crucial for decision makers in the water sector in particular in developing countries where WSS still represent an important leverage for livelihood improvement. In this framework, the Joint Research Centre of the European Commission has developed a coherent database (WatSan4Dev database) containing 29 indicators from environmental, socio-economic, governance and financial aid flows data focusing on developing countries (Celine et al, 2011 under publication). The aim of this work is to model the WatSan4Dev dataset using probabilistic models to identify the key variables influencing or being influenced by the water supply and sanitation access levels. Bayesian Network Models are suitable to map the conditional dependencies between variables and also allows ordering variables by level of influence on the dependent variable. Separated models have been built for water supply and for sanitation because of different behaviour. The models are validated if complying with statistical criteria but either with scientific knowledge and literature. A two steps approach has been adopted to build the structure of the model; Bayesian network is first built for each thematic cluster of variables (e.g governance, agricultural pressure, or human development) keeping a detailed level for interpretation later one. A global model is then built based on significant indicators of each cluster being previously modelled. The structure of the

  20. 100 kV reliable accurately-synchronized spark gap

    International Nuclear Information System (INIS)

    Bosamykin, V.S.; Gerasimov, A.I.; Zenkov, D.I.

    1987-01-01

    100 kV three-electrode spark gap filled with 40% SF 6 +60% N 2 mixture under the pressure of ∼ 1 MPa, which has spread Δt ≤ ± 5 ns of operating time delay in the range of 10 4 triggerings and commutation energy of 2.5 kJ, providing electric strength is 100%, is described; at 10 kJ Δt is less than ± 10 ns for 10 3 triggerings. Parallel connection of 16 groups, each consisting of 5 spark gaps with series connection, electric strength being 100%, in the pulse charging unit of Arkadiev-Marx generator being in operation for several years manifested their high efficiency; mutual group spread is ≤ ± 15 ns

  1. Do kV really make everything look grey? A comparative study of 600 kV computed tomography systems; Macht kV wirklich grau? Eine Vergleichsstudie zu 600 kV Computertomografiesystemen

    Energy Technology Data Exchange (ETDEWEB)

    Krumm, Michael; Sauerwein, Christoph; Haemmerle, Volker; Knupe, Gunnar [RayScan Technologies GmbH, Meersburg (Germany)

    2013-07-01

    In the automotive industry there is a manufacture of cast aluminium parts of considerable thickness. Growing importance is being attached to methods of nondestructive testing and full metrological characterisation of these parts. A major contribution to this end has been made by the latest generation of CT systems, whose 600 kV X-ray tubes and line detectors make for excellent image quality. The purpose of the present study was to make an objective assessment of the performance of these CT systems by examining the advantages and drawbacks of each. This included comparisons of various parameters such as tube voltage and exposure time as well as different tube and detector technologies and CT measurement methods.

  2. MFTF 230 kV pulsed power substation

    International Nuclear Information System (INIS)

    Wilson, J.H.

    1979-01-01

    The Mirror Fusion Test Facility (MFTF) currently under construction at the Lawrence Livermore Laboratory includes a Sustaining Neutral Beam Power Supply System (SNBPSS) consisting of 24 power-supply sets. The System will operate in long pulses (initially .5 seconds and eventually 30 seconds) at high power (200 MW), which will necessitate a large source of ac power. To meet this requirement, a new 230-kV substation is also being built at LLL. The constraints of cost, equipment protection, short operating lifetime (10 years), and reliability dictated a unique substation design. Its unusual features include provisions for fast fault detection and tripping, a capability for limiting ground fault current, low impedance, and economical design

  3. Faraday Rotator 5 kV Capacitor Bank

    International Nuclear Information System (INIS)

    Fetterman, C.C.

    1975-01-01

    A Faraday rotator 5 kV capacitor bank is a pulsed output power supply used to energize Faraday rotators for optical isolation in the ''LLL kJ Glass Laser System.'' Each supply contains either one, two or three parallel 240 μF storage capacitors depending on the size of the isolator used. Generally, the ''A*''(216 μH) isolator is energized with one capacitor, the ''A''(116 μH) isolator uses two capacitors and the ''B''(87 μH) isolator requires three capacitors. All models of isolators have been tested with four capacitors under maximum voltage and 25 feet of RG-217 cable with no hazardous effects. Except for the number of capacitors in each unit, the supplies are otherwise physically identical

  4. Development of a general method for obtaining the geometry of microfluidic networks

    International Nuclear Information System (INIS)

    Razavi, Mohammad Sayed; Salimpour, M. R.; Shirani, Ebrahim

    2014-01-01

    In the present study, a general method for geometry of fluidic networks is developed with emphasis on pressure-driven flows in the microfluidic applications. The design method is based on general features of network's geometry such as cross-sectional area and length of channels. Also, the method is applicable to various cross-sectional shapes such as circular, rectangular, triangular, and trapezoidal cross sections. Using constructal theory, the flow resistance, energy loss and performance of the network are optimized. Also, by this method, practical design strategies for the fabrication of microfluidic networks can be improved. The design method enables rapid prediction of fluid flow in the complex network of channels and is very useful for improving proper miniaturization and integration of microfluidic networks. Minimization of flow resistance of the network of channels leads to universal constants for consecutive cross-sectional areas and lengths. For a Y-shaped network, the optimal ratios of consecutive cross-section areas (A i+1 /A i ) and lengths (L i+1 /L i ) are obtained as A i+1 /A i = 2 −2/3 and L i+1 /L i = 2 −1/3 , respectively. It is shown that energy loss in the network is proportional to the volume of network. It is also seen when the number of channels is increased both the hydraulic resistance and the volume occupied by the network are increased in a similar manner. Furthermore, the method offers that fabrication of multi-depth and multi-width microchannels should be considered as an integral part of designing procedures. Finally, numerical simulations for the fluid flow in the network have been performed and results show very good agreement with analytic results

  5. The Role of Globe Innovation Networks in Development of Information Society

    Directory of Open Access Journals (Sweden)

    Anna T. Girenko

    2016-12-01

    Full Text Available The author explores the evolution of the concept of the information society. There is identified the role of the formation of global innovation networks. The formation of global innovation networks is carried out through coordination and cooperation of scientific and technological activities on the basis of bilateral and multilateral relations, information exchange, scientific and technical services areas of development, implementation of scientific-technical activities in the framework of the international organizations, as well as through the development of national and regional innovation networks.

  6. Development and Restructuring of Regional Production/Distribution Networks in East Asia

    OpenAIRE

    Mitsuyo ANDO

    2013-01-01

    This paper attempts to investigate the features of development and restructuring patterns of production/distribution networks in East Asia, mainly in machinery sectors, using international trade data at the most disaggregated level, to discuss their resilient nature, and to provide policy implications for the regional production networks and the economic development in the region. Although the negative impacts of the Global Financial Crisis (GFC) in 2008 were initially transmitted through the...

  7. Development of the disable software reporting system on the basis of the neural network

    Science.gov (United States)

    Gavrylenko, S.; Babenko, O.; Ignatova, E.

    2018-04-01

    The PE structure of malicious and secure software is analyzed, features are highlighted, binary sign vectors are obtained and used as inputs for training the neural network. A software model for detecting malware based on the ART-1 neural network was developed, optimal similarity coefficients were found, and testing was performed. The obtained research results showed the possibility of using the developed system of identifying malicious software in computer systems protection systems

  8. Software-Defined Radio Global System for Mobile Communications Transmitter Development for Heterogeneous Network Vulnerability Testing

    Science.gov (United States)

    2013-12-01

    AbdelWahab, “ 2G / 3G Inter-RAT Handover Performance Analysis,” Second European Conference on Antennas and Propagation, pp. 1, 8, 11–16, Nov. 2007. [19] J...RADIO GLOBAL SYSTEM FOR MOBILE COMMUNICATIONS TRANSMITTER DEVELOPMENT FOR HETEROGENEOUS NETWORK VULNERABILITY TESTING by Carson C. McAbee... MOBILE COMMUNICATIONS TRANSMITTER DEVELOPMENT FOR HETEROGENEOUS NETWORK VULNERABILITY TESTING 5. FUNDING NUMBERS 6. AUTHOR(S) Carson C. McAbee

  9. Burst analysis tool for developing neuronal networks exhibiting highly varying action potential dynamics

    Directory of Open Access Journals (Sweden)

    Fikret Emre eKapucu

    2012-06-01

    Full Text Available In this paper we propose a firing statistics based neuronal network burst detection algorithm for neuronal networks exhibiting highly variable action potential dynamics. Electrical activity of neuronal networks is generally analyzed by the occurrences of spikes and bursts both in time and space. Commonly accepted analysis tools employ burst detection algorithms based on predefined criteria. However, maturing neuronal networks, such as those originating from human embryonic stem cells (hESC, exhibit highly variable network structure and time-varying dynamics. To explore the developing burst/spike activities of such networks, we propose a burst detection algorithm which utilizes the firing statistics based on interspike interval (ISI histograms. Moreover, the algorithm calculates interspike interval thresholds for burst spikes as well as for pre-burst spikes and burst tails by evaluating the cumulative moving average and skewness of the ISI histogram. Because of the adaptive nature of the proposed algorithm, its analysis power is not limited by the type of neuronal cell network at hand. We demonstrate the functionality of our algorithm with two different types of microelectrode array (MEA data recorded from spontaneously active hESC-derived neuronal cell networks. The same data was also analyzed by two commonly employed burst detection algorithms and the differences in burst detection results are illustrated. The results demonstrate that our method is both adaptive to the firing statistics of the network and yields successful burst detection from the data. In conclusion, the proposed method is a potential tool for analyzing of hESC-derived neuronal cell networks and thus can be utilized in studies aiming to understand the development and functioning of human neuronal networks and as an analysis tool for in vitro drug screening and neurotoxicity assays.

  10. Optimization of 200 kV electrostatic accelerator

    Directory of Open Access Journals (Sweden)

    M Nazmabadi

    2015-09-01

    Full Text Available Optimizations on 200 kV electrostatic accelerator have been done in order to increasing ion current on target, improving vacuum condition and reduction in x-rays emission, increasing stability of high voltage power supply and reaching much greater achievable voltage value. The accelerator tube has most important effect on beam tracing in the electrostatic accelerators. So precautions most be considered in designing and constructing of this part. In order to finding permissible tolerances in construction and assembling of 200 kV electrostatic accelerator column, first the effects of angle deviation of a part from accelerator axis on beam track in the accelerator tube was simulated with Simion 7.0 computer program. We found that in order to prevent beam lost, the tolerances of balancing and co-centering of each part should be smaller than 0.1 mm. Each part of accelerator tube constructed by tolerances lower than 0.05 mm. Ultrasonic cleaning method used in pre-assembling process of parts. Because of its excellences, in the new tube we used borosilicate glass instead of high density alumina as insulators between the metallic electrodes. After three days of working vacuum pumps the system reached to 8.0×10-7 and after months to 5.0×10-7 ultimate pressure values. Measurements showed that by these considerations the maximum of reachable ion current on target was 1.1 mA which increased 50% compared to old machine, while x-ray emission intensity was increased by 25%. Optimizations of high voltage power supply are now under studies and tests

  11. The voltage-gated potassium channel subunit, Kv1.3, is expressed in epithelia

    DEFF Research Database (Denmark)

    Grunnet, Morten; Rasmussen, Hanne B; Hay-Schmidt, Anders

    2003-01-01

    The Shaker-type voltage-gated potassium channel, Kv1.3, is believed to be restricted in distribution to lymphocytes and neurons. In lymphocytes, this channel has gained intense attention since it has been proven that inhibition of Kv1.3 channels compromise T lymphocyte activation. To investigate...

  12. PKC and AMPK regulation of Kv1.5 potassium channels

    DEFF Research Database (Denmark)

    Andersen, Martin Nybo; Skibsbye, Lasse; Tang, Chuyi

    2015-01-01

    The voltage-gated Kv1.5 potassium channel, conducting the ultra-rapid rectifier K(+) current (IKur), is regulated through several pathways. Here we investigate if Kv1.5 surface expression is controlled by the 2 kinases PKC and AMPK, using Xenopus oocytes, MDCK cells and atrial derived HL-1 cells....

  13. Pharmacological dissection of K(v)7.1 channels in systemic and pulmonary arteries

    DEFF Research Database (Denmark)

    Chadha, Preet S; Zunke, Friederike; Davis, Alison J

    2012-01-01

    The aim of this study was to characterize the functional impact of KCNQ1-encoded voltage-dependent potassium channels (K(v)7.1) in the vasculature.......The aim of this study was to characterize the functional impact of KCNQ1-encoded voltage-dependent potassium channels (K(v)7.1) in the vasculature....

  14. A study on the insulation coordination of 765 kV system

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jeong Boo; Shim, Eung Bo [Korea Electric Power Corp. (KEPCO), Taejon (Korea, Republic of). Research Center; Lee, Yong Han; Youn, Jae Yeong; Hwang, Chi Woo; Jung, Dong Hak [Korea Electrotechnology Research Inst., Changwon (Korea, Republic of)

    1996-12-31

    Analysis of the power frequency temporary overvoltage. Analysis of switching surges - Fault imitation, closing and re closing, fault clearing. Analysis of lightning surges. Insulation design of 765 kV overhead transmission line. Insulation coordination of 765 kV gas insulated substation. Transient recovery voltage and high speed ground switch (author). 38 refs., 55 figs.

  15. KCNE3 is an inhibitory subunit of the Kv4.3 potassium channel

    DEFF Research Database (Denmark)

    Lundby, Alicia; Olesen, Søren-Peter

    2006-01-01

    The mammalian Kv4.3 potassium channel is a fast activating and inactivating K+ channel widely distributed in mammalian tissues. Kv4.3 is the major component of various physiologically important currents ranging from A-type currents in the CNS to the transient outward potassium conductance in the ...

  16. Recombinant expression of margatoxin and agitoxin-2 in Pichia pastoris: an efficient method for production of KV1.3 channel blockers.

    Directory of Open Access Journals (Sweden)

    Raveendra Anangi

    Full Text Available The K(v1.3 voltage-gated potassium channel regulates membrane potential and calcium signaling in human effector memory T cells that are key mediators of autoimmune diseases such as multiple sclerosis, type 1 diabetes, and rheumatoid arthritis. Thus, subtype-specific K(v1.3 blockers have potential for treatment of autoimmune diseases. Several K(v1.3 channel blockers have been characterized from scorpion venom, all of which have an α/β scaffold stabilized by 3-4 intramolecular disulfide bridges. Chemical synthesis is commonly used for producing these disulfide-rich peptides but this approach is time consuming and not cost effective for production of mutants, fusion proteins, fluorescently tagged toxins, or isotopically labelled peptides for NMR studies. Recombinant production of K(v1.3 blockers in the cytoplasm of E. coli generally necessitates oxidative refolding of the peptides in order to form their native disulfide architecture. An alternative approach that avoids the need for refolding is expression of peptides in the periplasm of E. coli but this often produces low yields. Thus, we developed an efficient Pichia pastoris expression system for production of K(v1.3 blockers using margatoxin (MgTx and agitoxin-2 (AgTx2 as prototypic examples. The Pichia system enabled these toxins to be obtained in high yield (12-18 mg/L. NMR experiments revealed that the recombinant toxins adopt their native fold without the need for refolding, and electrophysiological recordings demonstrated that they are almost equipotent with the native toxins in blocking K(V1.3 (IC(50 values of 201±39 pM and 97 ± 3 pM for recombinant AgTx2 and MgTx, respectively. Furthermore, both recombinant toxins inhibited T-lymphocyte proliferation. A MgTx mutant in which the key pharmacophore residue K28 was mutated to alanine was ineffective at blocking K(V1.3 and it failed to inhibit T-lymphocyte proliferation. Thus, the approach described here provides an efficient method of

  17. Developing 21st century skills through the use of student personal learning networks

    Science.gov (United States)

    Miller, Robert D.

    This research was conducted to study the development of 21st century communication, collaboration, and digital literacy skills of students at the high school level through the use of online social network tools. The importance of this study was based on evidence high school and college students are not graduating with the requisite skills of communication, collaboration, and digital literacy skills yet employers see these skills important to the success of their employees. The challenge addressed through this study was how high schools can integrate social network tools into traditional learning environments to foster the development of these 21st century skills. A qualitative research study was completed through the use of case study. One high school class in a suburban high performing town in Connecticut was selected as the research site and the sample population of eleven student participants engaged in two sets of interviews and learned through the use social network tools for one semester of the school year. The primary social network tools used were Facebook, Diigo, Google Sites, Google Docs, and Twitter. The data collected and analyzed partially supported the transfer of the theory of connectivism at the high school level. The students actively engaged in collaborative learning and research. Key results indicated a heightened engagement in learning, the development of collaborative learning and research skills, and a greater understanding of how to use social network tools for effective public communication. The use of social network tools with high school students was a positive experience that led to an increased awareness of the students as to the benefits social network tools have as a learning tool. The data supported the continued use of social network tools to develop 21st century communication, collaboration, and digital literacy skills. Future research in this area may explore emerging social network tools as well as the long term impact these tools

  18. CIRCUIT-DESIGN SOLUTIONS AND INFORMATION SUPPORT OF CITY ELECTRIC NETWORKS IN THE CONDITIONS OF THE SMART GRID

    Directory of Open Access Journals (Sweden)

    M. I. Fursanov

    2017-01-01

    Full Text Available The structure, circuit-design solutions and information support of the city electric networks in the conditions of the SMART GRID have been analyzed. It is demonstrated that the new conditions of functioning of electric power engineering, increasing demands for its technological state and reliability in most countries determined the transition to a restructuring of electrical networks to be based on the SMART GRID (intelligent power networks innovative new structure. The definitions of the SMART GRID, its various attributes and characteristics in most developed countries including Belarus are presented. It is revealed that the existing and future circuit and constructive solutions that can automate the process of managing modes of urban electric networks under the SMART GRID conditions are manifold. At present, the most common in distribution networks are the sources of distributed generation (combustion turbines, wind turbines, photovoltaic installations, mini-hydro, etc.. The patterns and problems of information traceability of a traditional urban networks of the unified energy system of Belarus have been analyzed, and it is demonstrated that in the conditions of the SMART GRID most of the problems of the control mode that are characteristic for traditional distribution networks 6–10 kV and 0.38 kV, lose their relevance. Therefore, the present article presents and features the main directions of development of automatic control modes of the SMART GRID.

  19. 130 kV 130 A High voltage switching mode power supply for neutral beam plasma heating: design issues

    International Nuclear Information System (INIS)

    Ganuza, D.; Del Rio, J.M.; Garcia, I.; Garcia, F.; Garcia de Madinabeitia, P.; Perez, A.; Zabaleta, J.R.

    2003-01-01

    The company JEMA has designed and manufactured two High Voltage Switching Mode Power Supplies (HVSMPS), rated at 130 kV dc and 130 A, each of which will feed the accelerator grids of two Positive Ion Neutral Injector (PINI) loads, to be installed at the Joint European Torus (EFDA-JET facility located at Culham, UK). The solution designed by JEMA includes two matching transformers which adapt the 36 kV of the JET AC power distribution network to the required 670 V at the secondary side. Additionally, such transformers provide a 30 deg.phase shift which is required by a 30000 A 12 pulse thyristor rectifier. The obtained and stabilised 650 V feed 120 IGBT invertors, which operate at 2778 Hz with modulated square waveform. Each invertor feeds a High Insulation High Frequency Transformer. The 120 transformers corresponding to one power supply are arranged in three oil filled tanks and provide the main insulation from the low voltage to the high voltage side. The square waveform obtained at the secondary of each transformer is rectified by means of a diode bridge. The connection in series of the 120 diode bridges provides the required 130 kV d.c. at the output. In order to protect the load, a redundant solid state crowbar has been designed. Such short circuiting device is composed of 26 Light Triggered Thyristors (LTTs), connected in series. Electrical simulations have been carried out in order to ensure that the system complies with the requirements of high accuracy and adequate protection of the load. The critical design of the High Voltage-High Frequency Transformers has also required electrostatic simulations of the electric field distribution

  20. Implementation of Particle Swarm Optimization Method for Voltage Stability Analysis in 150 kV Sub System Grati – Paiton East Java

    Science.gov (United States)

    Kusumaningtyas, A. B.; Hidayat, M. N.; Ronilaya, F.

    2018-04-01

    Based on the data from State Electric Company on 15 January 2013, the undistributed power in the 150 kV sub system Grati-Paiton Region IV, that consist of 26 bus 150 kV and 2 bus generation 500 kV system, was recorded 3.286,00 MW. At the same time, the frequency of the system was down to 49 Hz. This lead to a deficit generation and unstable voltage condition in the system. Fast Voltage Stability Index (FVSI) method is used in this research to analyze the voltage stability of the buses. For buses with unstable voltage condition, reactive power will be injected through capacitor installation. The site where the capacitor will be installed is determined using the Fast Voltage Stability Index (FVSI) method while the size of the capacitor is determined using the Particle Swarm Optimization (PSO) method. The PSO method has been applied in some researches, such as to determine optimal placement and sizing in radial distribution network as well as in transmission network.. In this research, the PSO method is used to find the Qloss of an interconnection transmission system, which in turn, the value of the Qloss is used to determine the capacitance of the capacitor needed by the system.