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Sample records for ku jen lei

  1. PanJen

    DEFF Research Database (Denmark)

    Jensen, Cathrine Ulla; Panduro, Toke Emil

    functional transformations, driven by an a priori and theory-based hypothesis. The plots and model fit metrics enable users to make an informed choice of how to specify the functional form the regression. We show that the PanJen ranking outperforms the Box-Tidwell transformation, especially in the presence...... of inefficiency, heteroscedasticity or endogeneity....

  2. Annual report on JEN-1 and JEN-2 Reactors

    International Nuclear Information System (INIS)

    Montes Ponce de Leon, J.

    1974-01-01

    In the annual report on the JEN-1 and JEN-2 reactors the main fractures of the reactor operations and maintenance are described. The reactor has been in operation for 2188 hours, what means 74% of the total working time. Maintenance and periodical tests have occupied the rest of the time. Maintenance operations are shown according to three main subjects, the main failures so as the reactor scrams are also described. Different date relating with radiation level and health Physics are also included. (Author)

  3. Jens Beckert, 2016, Fraud and Fantasy

    DEFF Research Database (Denmark)

    Harrington, Brooke

    2017-01-01

    Contribution to review symposium on: Jens Beckert (2016): Imagined Futures. Fictional Expectations and Capitalist Dynamics. Harvard University Press. Other ontributions from: Akos Rona-Tas (University of California, San Diego) ; William Deringer (Massachusetts Institute of Technology) and Jenny...

  4. Er KU et mobbeuniversitet?

    DEFF Research Database (Denmark)

    Olden-Jørgensen, Sebastian

    2009-01-01

    Ansatte på KU mobber hverken mere eller mindre end på andre danske arbejdspladser. Mediernes dækning af APV-undersøgelsens resultater mht. mobning er sensationalistisk og delvis vildledende.......Ansatte på KU mobber hverken mere eller mindre end på andre danske arbejdspladser. Mediernes dækning af APV-undersøgelsens resultater mht. mobning er sensationalistisk og delvis vildledende....

  5. Annual report on JEN-1 and JEN-2 Reactors; Informe periodico de Reactores JEN-1 y JEN-2 correpondiente al ano 1972

    Energy Technology Data Exchange (ETDEWEB)

    Montes Ponce de Leon, J.

    1974-07-01

    In the annual report on the JEN-1 and JEN-2 reactors the main fractures of the reactor operations and maintenance are described. The reactor has been in operation for 2188 hours, what means 74% of the total working time. Maintenance and periodical tests have occupied the rest of the time. Maintenance operations are shown according to three main subjects, the main failures so as the reactor scrams are also described. Different date relating with radiation level and health Physics are also included. (Author)

  6. Jens Haug keelab oma lastel majandust õppida / Piret Reiljan

    Index Scriptorium Estoniae

    Reiljan, Piret, 1983-

    2006-01-01

    Endine ärimees Jens Haug õpib ülikoolis semiootikat ja töötab majandus- ja kommunikatsiooniministeeriumis kriisireguleerimise osakonnas. Vt. samas: Kolleeg hindab Jens Haugi teravat mõistust; Karjäär

  7. Determination flux in the Reactor JEN-1

    International Nuclear Information System (INIS)

    Manas Diaz, L.; Montes Ponce de leon, J.

    1960-01-01

    This report summarized several irradiations that have been made to determine the neutron flux distributions in the core of the JEN-1 reactor. Gold foils of 380 μ gr and Mn-Ni (12% de Ni) of 30 mg have been employed. the epithermal flux has been determined by mean of the Cd radio. The resonance integral values given by Macklin and Pomerance have been used. (Author) 9 refs

  8. Ivor Jennings's Constitutional Legacy beyond the Occidental-Oriental Divide

    OpenAIRE

    Malagodi, M.

    2015-01-01

    Sir W. Ivor Jennings (1903–1965) was one of Britain's most prominent constitutional law scholars of the twentieth century. He is mostly famed for his work in the 1930s on English Public Law. In 1941, Jennings, however, moved to Sri Lanka, progressively becoming involved in both an academic and professional capacity with constitutional processes across the decolonizing world in the early stages of the Cold War. This article provides an alternative account of Jennings's constitutional legacy to...

  9. Annual report on JEN-1 reactor

    International Nuclear Information System (INIS)

    Montes, J.

    1972-01-01

    In the annual report on the JEN-1 reactor the main features of the reactor operations and maintenance are described. The reactor has been critical for 1831 hours, what means 65,8% of the total working time. Maintenance and pool water contamination have occupied the rest of the time. The maintenance schedule is shown in detail according to three subjects. The main failures and reactor scrams are also described. The daily maximum values of the water activity are given so as the activity of the air in the reactor hall. (Author)

  10. Pametna kuća

    OpenAIRE

    Rade, Sanjin

    2015-01-01

    Uslijed ubrzanog napretka u bežičnoj komunikaciji i informacijskim tehnologijama, sada je moguće uvesti i implementirati različite razine „pametnosti“ u kuće. Ove pametne kuće su kuće koje mogu da se inteligentno uključe u razne interakcije sa svojim stanovnicima da bi im omogućile udobnost i siguran život. Ovo uključivanje u živote svojih stanara može varirati od jednostavne kontrole ambijentne temperature do ispunjavanja usluga koje su zasnovane na mobilnim agentima. Pametne kuće imaju ...

  11. Core optimization studies at JEN-Spain

    International Nuclear Information System (INIS)

    Gomez Alonso, M.

    1983-01-01

    The JEN-1 is a 3-MW reactor which uses flat-plate fuel elements. It was originally fueled with 20%-enriched uranium but more recently with 90%-enriched fuel. It now appears that it will have to be converted back to using 20%- enriched fuel. Progress is presently being made in fuel fabrication. Plates with meat thicknesses of up to 1.5 mm have been fabricated. Plates are being tested with 40 wt % uranium in the fuel meat. Progress is also being made in reactor design in collaboration with atomic energy commissions of other countries for swimming pool reactors being designed or under construction in Chile, Ecuador, and Spain itself. The design studies address core optimization, safety analysis report updating, irradiation facilities, etc. Core optimization is specifically addressed in this paper. A common swimming-pool-type reactor such as the JEN-1 served as an example. The philosophy adopted in this study is not to try to match the high enrichment core, but rather to treat the design as new and try to optimize it using simplified neutronic/thermal hydraulic/economic models. This philosophy appears to be somewhat original. As many as possible of the fuel parameters are constrained to remain constant

  12. Annual report on JEN-1 reactor; Informe periodico del Reactor JEN-1 correspondiente al ano 1971

    Energy Technology Data Exchange (ETDEWEB)

    Montes, J

    1972-07-01

    In the annual report on the JEN-1 reactor the main features of the reactor operations and maintenance are described. The reactor has been critical for 1831 hours, what means 65,8% of the total working time. Maintenance and pool water contamination have occupied the rest of the time. The maintenance schedule is shown in detail according to three subjects. The main failures and reactor scrams are also described. The daily maximum values of the water activity are given so as the activity of the air in the reactor hall. (Author)

  13. A LEI E AS LEIS: CENÁRIOS E CENAS NA APLICAÇÃO DA LEI MARIA DA PENHA

    Directory of Open Access Journals (Sweden)

    Jair José Schuh

    2016-03-01

    Full Text Available Este artigo é uma versão revista e ampliada de um trabalho originalmente veiculado por nós quando da realização do 3o Encontro Nacional do Corpo Freudiano Escola de Psicanálise, que teve por tema “A psicanálise e Lei”. Nele, pretendemos nos debruçar sobre a interface entre Psicanálise e Direito, mais especificamente nos ocuparemos de cenários e cenas que dizem respeito a aplicação da Lei 11. 340/06, que leva o nome de Lei Maria da Penha. Isso nos levará a uma discussão mais ampla acerca da própria feitura das Leis. O referencial teórico e metodológico do qual nos utilizamos para esse fim tem por base as contribuições de Freud, Lacan, bem como de psicanalistas contemporâneos que tratam mais de perto das relações entre o Direito e a Psicanálise e entre a Lei e as leis.

  14. Towards a New Confessionalism: Elizabeth Jennings and Sylvia Plath

    OpenAIRE

    Dowson, Jane

    2011-01-01

    Due to their self-disclosing manner, both Elizabeth Jennings (1926-2001) and Sylvia Plath (1932-63) have been labelled ‘confessional’ yet have markedly different life experiences and profiles in literary and popular imaginations. Jennings was born in Boston, Lincolnshire, and educated in Oxford where she lived for the rest of her life. She had a broken engagement then a relationship with a married man but never married or had children. Plath emigrated to Cambridge University from America in 1...

  15. Outrunning Asthma: Football Player Rashad Jennings Battled Childhood Asthma with Exercise and Determination

    Science.gov (United States)

    ... us Outrunning Asthma Football player Rashad Jennings battled childhood asthma with exercise and determination Photo: ABC National Football ... Dancing with the Stars” champion Rashad Jennings battled childhood asthma with grit and determination. He has partnered with ...

  16. Recurring themes in the legacy of Jens Rasmussen

    DEFF Research Database (Denmark)

    Waterson, Patrick; Le Coze, Jean-Christophe; Andersen, Henning Boje

    2016-01-01

    The work of Jens Rasmussen over the course of the last half century represents some of the most influential contributions to the fields of cognitive science, human factors, ergonomics and safety science. His work has inspired researchers and practitioners in a number of fields including psycholog...

  17. Identification and analysis of Ku70 and Ku80 homologs in the koji molds Aspergillus sojae and Aspergillus oryzae.

    Science.gov (United States)

    Takahashi, Tadashi; Masuda, Tsutomu; Koyama, Yasuji

    2006-01-01

    Ku genes play a key role in the non-homologous end-joining pathway. We have identified Ku70 and Ku80 homologs in the koji molds Aspergillus sojae and Aspergillus oryzae, and have constructed the disruption mutants of Ku70, Ku80, and Ku70-80 to characterize the phenotypic change in these mutants. Neither Ku70- nor Ku80-disrupted strains show hypersensitivity to the DNA damaging agents methylmethane sulfonate (MMS) and phleomycin. Moreover, undesirable phenotypes, such as poor growth or repressed conidiospore formation, were not observed in the Ku-disrupted A. sojae and A. oryzae.

  18. Molecular analysis of Ku redox regulation

    Directory of Open Access Journals (Sweden)

    Shatilla Andrea

    2009-08-01

    Full Text Available Abstract Background DNA double-strand breaks (DSBs can occur in response to ionizing radiation (IR, radiomimetic agents and from endogenous DNA-damaging reactive oxygen metabolites. Unrepaired or improperly repaired DSBs are potentially the most lethal form of DNA damage and can result in chromosomal translocations and contribute to the development of cancer. The principal mechanism for the repair of DSBs in humans is non-homologous end-joining (NHEJ. Ku is a key member of the NHEJ pathway and plays an important role in the recognition step when it binds to free DNA termini. Ku then stimulates the assembly and activation of other NHEJ components. DNA binding of Ku is regulated by redox conditions and evidence from our laboratory has demonstrated that Ku undergoes structural changes when oxidized that results in a reduction in DNA binding activity. The C-terminal domain and cysteine 493 of Ku80 were investigated for their contribution to redox regulation of Ku. Results We effectively removed the C-terminal domain of Ku80 generating a truncation mutant and co-expressed this variant with wild type Ku70 in an insect cell system to create a Ku70/80ΔC heterodimer. We also generated two single amino acid variants of Cys493, replacing this amino acid with either an alanine (C493A or a serine (C493S, and over-expressed the variant proteins in SF9 insect cells in complex with wild type Ku70. Neither the truncation nor the amino acid substitutions alters protein expression or stability as determined by SDS-PAGE and Western blot analysis. We show that the C493 mutations do not alter the ability of Ku to bind duplex DNA in vitro under reduced conditions while truncation of the Ku80 C-terminus slightly reduced DNA binding affinity. Diamide oxidation of cysteines was shown to inhibit DNA binding similarly for both the wild-type and all variant proteins. Interestingly, differential DNA binding activity following re-reduction was observed for the Ku70/80

  19. Determination flux in the Reactor JEN-1; Medida de flujos de neutrones en el nucleo del Reactor JEN-1

    Energy Technology Data Exchange (ETDEWEB)

    Manas Diaz, L; Montes Ponce de leon, J.

    1960-07-01

    This report summarized several irradiations that have been made to determine the neutron flux distributions in the core of the JEN-1 reactor. Gold foils of 380 {mu} gr and Mn-Ni (12% de Ni) of 30 mg have been employed. the epithermal flux has been determined by mean of the Cd radio. The resonance integral values given by Macklin and Pomerance have been used. (Author) 9 refs.

  20. Afsluttende kommentar til Jens Ravnkildes tre artikler om retskildebegrebet

    DEFF Research Database (Denmark)

    Holtermann, Jakob v. H.; Olsen, Henrik Palmer

    2014-01-01

    I dette andet svar til Dr. Jur. Jens Ravnkildes fortsatte forsvar for sit tidligere fremsatte forslag til et retskildebegreb klargør og udbygger lektor Jakob v. H. Holtermann og professor Henrik Palmer Olsen deres kritik yderligere. I den forbindelse afviser de også Ravnkildes ganske sensationell...... påstand om, at Ross blot fem år før sin død i 1979 helt skulle have forladt sit livsværk og opgivet sin karakteristiske version af retsrealismen til fordel for traditionel kelseniansk retspositivisme...

  1. Aquilo que nomeia lei: a Madre Tierra

    Directory of Open Access Journals (Sweden)

    Cristina Zanella Rodrigues

    2017-11-01

    Full Text Available Este texto é sustentado teoricamente na Análise do Discurso de viés pêcheuxtiano e tem por corpus dois textos legais: a Ley de Derechos de La Madre Tierra (Ley nº 71/2010 e a Ley Marco de La Madre Tierra y Desarrollo Integral para Vivir Bien (Ley nº 300/2012 aprovadas na Bolívia. A irrupção da Madre Tierra como nome de lei faz ecoar, do lugar da voz dos povos originários, a memória cosmovisionária como discurso da resistência contra o silenciamento de uma história.  Ao atentar para o processo de subjetivação e os ruídos que este acontecimento pode ocasionar, há por objetivo analisar que efeitos de sentido e deslocamentos teóricos são produzidos a partir das formas de nomear, designar, referenciar, subjetivar a Madre Tierra na sua materialização linguístico-discursiva num texto legal. E como se podem operar os conceitos de falta, excesso e estranhamento (ERNST, 2009 no trabalho de análise do nome que nomeia uma lei.

  2. Karikaturist Aivar Juhanson näitab KuKu klubis oma töid

    Index Scriptorium Estoniae

    2009-01-01

    Loit Jõekalda kureeritud joonistustriennaali raames eksponeerivad oma töid Ave Avalo, Kärt Hammer, Eero Ijavoinen, Kristjan Kittus, Mari-Liis Laanemaa, Triinu Lille, Valli Lember-Bogatkina jpt. kunstnikud. Ajalehe "Eesti Ekspress" karikaturisti Aivar Juhansoni tööde näitus Tallinnas KuKu klubis

  3. Thermal and hydraulic characteristics of the JEN-1 Reactor; Caracteristicas hidraulicas y termicas del Reactor JEN-1

    Energy Technology Data Exchange (ETDEWEB)

    Otra Otra, F; Leira Rey, G

    1971-07-01

    In this report an analysis is made of the thermal and hydraulic performances of the JEN-1 reactor operating steadily at 3 Mw of thermal power. The analysis is made separately for the core, main heat exchanger and cooling tower. A portion of the report is devoted to predict the performances of these three main components when and if the reactor was going to operate at a power higher than the maximum 3 Mw attainable today. Finally an study is made of the unsteady operation of the reactor, focusing the attention towards the pumping characteristics and the temperatures obtained in the fuel elements. Reference is made to several digital calculation programmes that nave been developed for such purpose. (Author) 21 refs.

  4. A distilled fire of thirteen hells – Jens Baggesen between the Germans and the Danes

    DEFF Research Database (Denmark)

    Blicher, Henrik

    Venskabet mellem Carl Friedrich Cramer og Jens Baggesen blev et politisk anliggende for første gang under den såkaldte Tyskerfejde i 1789, da latente spændinger mellem en indflydelsesrig tysk gruppering i København en og en større nationalt orienteret gruppe borgere blev til åben konflikt. Jens B...... tyske aristokrati i København. Det prekære forhold har sat sig indirekte, men tydelige spor i rejseskildringen Labyrinten (bd. 1-2, 1792-93), der på denne baggrund fremstår som en apologi for Jens Baggesens position....

  5. Ku80-deleted cells are defective at base excision repair

    International Nuclear Information System (INIS)

    Li, Han; Marple, Teresa; Hasty, Paul

    2013-01-01

    Graphical abstract: - Highlights: • Ku80-deleted cells are hypersensitive to ROS and alkylating agents. • Cells deleted for Ku80, but not Ku70 or Lig4, have reduced BER capacity. • OGG1 rescues hypersensitivity to H 2 O 2 and paraquat in Ku80-mutant cells. • Cells deleted for Ku80, but not Lig4, are defective at repairing AP sites. • Cells deleted for Ku80, but not Lig4 or Brca2 exon 27, exhibit increased PAR. - Abstract: Ku80 forms a heterodimer with Ku70, called Ku, that repairs DNA double-strand breaks (DSBs) via the nonhomologous end joining (NHEJ) pathway. As a consequence of deleting NHEJ, Ku80-mutant cells are hypersensitive to agents that cause DNA DSBs like ionizing radiation. Here we show that Ku80 deletion also decreased resistance to ROS and alkylating agents that typically cause base lesions and single-strand breaks (SSBs). This is unusual since base excision repair (BER), not NHEJ, typically repairs these types of lesions. However, we show that deletion of another NHEJ protein, DNA ligase IV (Lig4), did not cause hypersensitivity to these agents. In addition, the ROS and alkylating agents did not induce γ-H2AX foci that are diagnostic of DSBs. Furthermore, deletion of Ku80, but not Lig4 or Ku70, reduced BER capacity. Ku80 deletion also impaired BER at the initial lesion recognition/strand scission step; thus, involvement of a DSB is unlikely. Therefore, our data suggests that Ku80 deletion impairs BER via a mechanism that does not repair DSBs

  6. Ku80-deleted cells are defective at base excision repair

    Energy Technology Data Exchange (ETDEWEB)

    Li, Han [The University of Texas Health Science Center at San Antonio, The Institute of Biotechnology, The Department of Molecular Medicine, 15355 Lambda Drive, San Antonio, TX 78245-3207 (United States); Tumor Suppression Group, Spanish National Cancer Research Centre (CNIO), Madrid 28029 (Spain); Marple, Teresa [The University of Texas Health Science Center at San Antonio, The Institute of Biotechnology, The Department of Molecular Medicine, 15355 Lambda Drive, San Antonio, TX 78245-3207 (United States); Hasty, Paul, E-mail: hastye@uthscsa.edu [The University of Texas Health Science Center at San Antonio, The Institute of Biotechnology, The Department of Molecular Medicine, 15355 Lambda Drive, San Antonio, TX 78245-3207 (United States); Tumor Suppression Group, Spanish National Cancer Research Centre (CNIO), Madrid 28029 (Spain)

    2013-05-15

    Graphical abstract: - Highlights: • Ku80-deleted cells are hypersensitive to ROS and alkylating agents. • Cells deleted for Ku80, but not Ku70 or Lig4, have reduced BER capacity. • OGG1 rescues hypersensitivity to H{sub 2}O{sub 2} and paraquat in Ku80-mutant cells. • Cells deleted for Ku80, but not Lig4, are defective at repairing AP sites. • Cells deleted for Ku80, but not Lig4 or Brca2 exon 27, exhibit increased PAR. - Abstract: Ku80 forms a heterodimer with Ku70, called Ku, that repairs DNA double-strand breaks (DSBs) via the nonhomologous end joining (NHEJ) pathway. As a consequence of deleting NHEJ, Ku80-mutant cells are hypersensitive to agents that cause DNA DSBs like ionizing radiation. Here we show that Ku80 deletion also decreased resistance to ROS and alkylating agents that typically cause base lesions and single-strand breaks (SSBs). This is unusual since base excision repair (BER), not NHEJ, typically repairs these types of lesions. However, we show that deletion of another NHEJ protein, DNA ligase IV (Lig4), did not cause hypersensitivity to these agents. In addition, the ROS and alkylating agents did not induce γ-H2AX foci that are diagnostic of DSBs. Furthermore, deletion of Ku80, but not Lig4 or Ku70, reduced BER capacity. Ku80 deletion also impaired BER at the initial lesion recognition/strand scission step; thus, involvement of a DSB is unlikely. Therefore, our data suggests that Ku80 deletion impairs BER via a mechanism that does not repair DSBs.

  7. Jens Glad Balchen: A Norwegian Pioneer in Engineering Cybernetics

    Directory of Open Access Journals (Sweden)

    Morten Breivik

    2009-07-01

    Full Text Available This paper tells the story of Jens Glad Balchen (1926-2009, a Norwegian research scientist and engineer who is widely regarded as the father of Engineering Cybernetics in Norway. In 1954, he founded what would later become the Department of Automatic Control at the Norwegian Institute of Technology in Trondheim. This name was changed to the Department of Engineering Cybernetics in 1972 to reflect the broader efforts being made, not only within the purely technical disciplines, but also within biology, oceanography and medicine. Balchen established an advanced research community in cybernetics in postwar Norway, whose applications span everything from the process industry and positioning of ships to control of fish and lobster farming. He was a chief among the tribe of Norwegian cybernetics engineers and made a strong impact on his colleagues worldwide. He planted the seeds of a whole generation of Norwegian industrial companies through his efforts of seeking applications for every scientific breakthrough. His strength and his wisdom in combination with his remarkable stubbornness gave extraordinary results.

  8. Inhibition of Ku70 acetylation by INHAT subunit SET/TAF-Iβ regulates Ku70-mediated DNA damage response.

    Science.gov (United States)

    Kim, Kee-Beom; Kim, Dong-Wook; Park, Jin Woo; Jeon, Young-Joo; Kim, Daehwan; Rhee, Sangmyung; Chae, Jung-Il; Seo, Sang-Beom

    2014-07-01

    DNA double-strand breaks (DSBs) can cause either cell death or genomic instability. The Ku heterodimer Ku70/80 is required for the NHEJ (non-homologous end-joining) DNA DSB repair pathway. The INHAT (inhibitor of histone acetyltransferases) complex subunit, SET/TAF-Iβ, can inhibit p300- and PCAF-mediated acetylation of both histone and p53, thereby repressing general transcription and that of p53 target genes. Here, we show that SET/TAF-Iβ interacts with Ku70/80, and that this interaction inhibits CBP- and PCAF-mediated Ku70 acetylation in an INHAT domain-dependent manner. Notably, DNA damage by UV disrupted the interaction between SET/TAF-Iβ and Ku70. Furthermore, we demonstrate that overexpressed SET/TAF-Iβ inhibits recruitment of Ku70/80 to DNA damage sites. We propose that dysregulation of SET/TAF-Iβ expression prevents repair of damaged DNA and also contributes to cellular proliferation. All together, our findings indicate that SET/TAF-Iβ interacts with Ku70/80 in the nucleus and inhibits Ku70 acetylation. Upon DNA damage, SET/TAF-Iβ dissociates from the Ku complex and releases Ku70/Ku80, which are then recruited to DNA DSB sites via the NHEJ DNA repair pathway.

  9. EpiJen: a server for multistep T cell epitope prediction

    Directory of Open Access Journals (Sweden)

    Guan Pingping

    2006-03-01

    Full Text Available Abstract Background The main processing pathway for MHC class I ligands involves degradation of proteins by the proteasome, followed by transport of products by the transporter associated with antigen processing (TAP to the endoplasmic reticulum (ER, where peptides are bound by MHC class I molecules, and then presented on the cell surface by MHCs. The whole process is modeled here using an integrated approach, which we call EpiJen. EpiJen is based on quantitative matrices, derived by the additive method, and applied successively to select epitopes. EpiJen is available free online. Results To identify epitopes, a source protein is passed through four steps: proteasome cleavage, TAP transport, MHC binding and epitope selection. At each stage, different proportions of non-epitopes are eliminated. The final set of peptides represents no more than 5% of the whole protein sequence and will contain 85% of the true epitopes, as indicated by external validation. Compared to other integrated methods (NetCTL, WAPP and SMM, EpiJen performs best, predicting 61 of the 99 HIV epitopes used in this study. Conclusion EpiJen is a reliable multi-step algorithm for T cell epitope prediction, which belongs to the next generation of in silico T cell epitope identification methods. These methods aim to reduce subsequent experimental work by improving the success rate of epitope prediction.

  10. PREFACE: Festschrift to mark the sixtieth birthday of Professor Jens Lothe

    Science.gov (United States)

    Jøssang, Torstein; Barnett, David M.

    1992-01-01

    The collection of papers in this Festschrift represents the proceedings of a symposium held at the Norwegian Academy of Science and Letters on November 25-26, 1991, marking the occasion of the sixtieth birthday of Professor Jens Lothe. The symposium organizers attempted to invite contributors, either written, oral, or both, from a group of international scientists who have either collaborated with Jens in the past or whose work has had a significant impact in one of three areas in which Jens has focussed his own research interests, namely, statistical physics, elasticity and elastic waves, and the theory of dislocations in crystalline solids. The extent to which we have succeeded in obtaining a proper spectrum of contributors and contributions must be judged by the readers of this volume. It is rather rare in modern times to encounter a physicist such as Jens who has made seminal contributions in fields as diverse as the three included in this Festschrift. For this reason it is both historically interesting and instructive to follow the path that Jens Lothe's research career has taken him, since doing so clearly points out the international nature of the scientific endeavor and the fact that the search for scientific truth transcends national borders and governmental ideologies. Jens' postdoctoral studies at the University of Bristol in the late 1950s brought him in contact with an American postdoctoral student, John Hirth, who had worked on nucleation theory and condensation under the late Professor G M Pound at Carnegie-Mellon University. (Alex Maradudin, one of the contributors to the surface wave session of this symposium was also a postdoctoral fellow at Bristol at this time.) Both Lothe and Hirth had come to Bristol to acquaint themselves with dislocation theory; their first joint paper on double-kink nucleation theory was followed by numerous joint efforts, including their now-classic book Theory of Dislocations. Clearly, their interaction jelled. As legend

  11. 13-16-vuotiaiden tyypin 1 diabetesta sairastavien tyttöjen liikuntatottumukset

    OpenAIRE

    Vainionpää, Milja; Mykkänen, Janika

    2016-01-01

    Opinnäytetyön tavoitteena oli tuottaa tietoa terveydenhuollon ammattihenkilöille 13–16-vuotiaiden tyypin 1 diabetesta sairastavien tyttöjen liikuntatottumuksista ja liikunnan harrastamisesta. Opinnäytetyön tarkoituksena oli kuvailla 13–16-vuotiaiden tyypin 1 diabetesta sairastavien tyttöjen liikuntatottumuksia sekä selvittää, mitkä tekijät edistävät tai hankaloittavat liikunnan harrastamista. Tutkimuskysymyksiä olivat: 1. Minkälaisia ovat 13–16-vuotiaiden tyypin 1 diabetesta sairastavi...

  12. An Investigation of the Painting Technique in Portraits by Jens Juel

    DEFF Research Database (Denmark)

    Slotsgaard, Tine Louise

    2014-01-01

    This paper summarizes the findings of the first technical art historical study executed on paintings by the Danish portrait painter Jens Juel. Eight portrait paintings on canvas from two different time periods in the career of Jens Juel have been examined and compared in order to establish the use...... of materials, working methods and painting techniques, and whether an artistic development can be traced. The findings include the characteristics of the canvas structure and painting grounds, how the canvas was prepared and the artist’s use of underdrawing, as well as the layered build up of the carnation...

  13. Volba řešitelských strategií v závislosti na věku

    Directory of Open Access Journals (Sweden)

    Petr Eisenmann

    2017-12-01

    Full Text Available Příspěvek popisuje experiment, který byl součástí dlouhodobého výzkumu Rozvíjení kultury řešení matematických problémů ve školské praxi. Experiment byl proveden na vzorku celkem 584 respondentů ve věku 11–17 let a mapuje vývoj ve volbě řešitelských strategií matematických úloh u různých věkových skupin žáků. Žákům 6. a 8. ročníku základní školy, I. a III. ročníku střední školy byly předloženy tři úlohy, které se dají efektivně řešit pomocí heuristických strategií. Kromě úspěšnosti řešení úloh byla věnována pozornost také způsobu jejich řešení. Výsledkem experimentu je zjištění, že existují heuristické strategie, které žáci použili při řešení úloh i přesto, že s nimi ve výuce nebyli seznámeni. U některých z nich se jejich výskyt nemění v závislosti na věku.

  14. Kuldar Leis : Eesti jäätiseturul vennatapusõda ei ole / Kuldar Leis ; interv. Gaili Eding

    Index Scriptorium Estoniae

    Leis, Kuldar, 1968-

    2008-01-01

    Jäätisetootja Premia Tallinna Külmhoone ASi juhatuse esimehe Kuldar Leisi sõnul on Eesti jäätiseturg hästi välja kujunenud. Balbiinot peab ta väga mõistlikuks konkurendiks, kes ajab samamoodi õiget Eesti asja ja toodab häid jäätiseid. Lisa: Kuldar Leis

  15. Desarmamento no Brasil: Lei 9.437/97 x Lei 10.826/03

    Directory of Open Access Journals (Sweden)

    Márcio Santos Aleixo

    2015-02-01

    Full Text Available A segregação da sociedade brasileira, somada a histórica e farta disponibilidade de armas de fogo e munição, acarreta em elevados índices de criminalidade. Contudo, observa-se grande evolução na legislação brasileira relativa às armas de fogo visando restringir seu acesso, datando do início do século XVII aos dias atuais. Nesse sentido, o presente trabalho teve como objetivo discutir acerca do controle normativo das armas de fogo por parte do Estado, dando base para uma futura convalidação da eficiência de sua estratégia. Assim, por meio da revisão da literatura, levantou-se um breve histórico referente às normas que visam controlar o comércio e uso de armas de fogo no Brasil e teceu-se uma comparação entre as Leis 9.437/97 e 10.826/03. Por fim, fica claro que aumenta gradativamente a restrição à compra e ao porte de armas de fogo no Brasil, assim como a coerência ao tipificar e cominar penas diferentes frente a diferentes condutas por parte do agente.

  16. A moonlighting function of Mycobacterium smegmatis Ku in zinc homeostasis?

    Science.gov (United States)

    Kushwaha, Ambuj K; Deochand, Dinesh K; Grove, Anne

    2015-02-01

    Ku protein participates in DNA double-strand break repair via the nonhomologous end-joining pathway. The three-dimensional structure of eukaryotic Ku reveals a central core consisting of a β-barrel domain and pillar and bridge regions that combine to form a ring-like structure that encircles DNA. Homologs of Ku are encoded by a subset of bacterial species, and they are predicted to conserve this core domain. In addition, the bridge region of Ku from some bacteria is predicted from homology modeling and sequence analyses to contain a conventional HxxC and CxxC (where x is any residue) zinc-binding motif. These potential zinc-binding sites have either deteriorated or been entirely lost in Ku from other organisms. Using an in vitro metal binding assay, we show that Mycobacterium smegmatis Ku binds two zinc ions. Zinc binding modestly stabilizes the Ku protein (by ∼3°C) and prevents cysteine oxidation, but it has little effect on DNA binding. In vivo, zinc induces significant upregulation of the gene encoding Ku (∼sixfold) as well as a divergently oriented gene encoding a predicted zinc-dependent MarR family transcription factor. Notably, overexpression of Ku confers zinc tolerance on Escherichia coli. We speculate that zinc-binding sites in Ku proteins from M. smegmatis and other mycobacterial species have been evolutionarily retained to provide protection against zinc toxicity without compromising the function of Ku in DNA double-strand break repair. © 2014 The Protein Society.

  17. Mycobacterium smegmatis Ku binds DNA without free ends.

    Science.gov (United States)

    Kushwaha, Ambuj K; Grove, Anne

    2013-12-01

    Ku is central to the non-homologous end-joining pathway of double-strand-break repair in all three major domains of life, with eukaryotic homologues being associated with more diversified roles compared with prokaryotic and archaeal homologues. Ku has a conserved central 'ring-shaped' core domain. While prokaryotic homologues lack the N- and C-terminal domains that impart functional diversity to eukaryotic Ku, analyses of Ku from certain prokaryotes such as Pseudomonas aeruginosa and Mycobacterium smegmatis have revealed the presence of distinct C-terminal extensions that modulate DNA-binding properties. We report in the present paper that the lysine-rich C-terminal extension of M. smegmatis Ku contacts the core protein domain as evidenced by an increase in DNA-binding affinity and a decrease in thermal stability and intrinsic tryptophan fluorescence upon its deletion. Ku deleted for this C-terminus requires free DNA ends for binding, but translocates to internal DNA sites. In contrast, full-length Ku can directly bind DNA without free ends, suggesting that this property is conferred by its C-terminus. Such binding to internal DNA sites may facilitate recruitment to sites of DNA damage. The results of the present study also suggest that extensions beyond the shared core domain may have independently evolved to expand Ku function.

  18. [Jennings Randolph Forum (3rd, Washington, District of Columbia, May 20-22, 1984).

    Science.gov (United States)

    CAC Citizenship Education News, 1984

    1984-01-01

    This overview of the third annual Jennings Randolph Forum focuses on the role that election campaigns and the political process are capable of playing in citizenship education. Council for the Advancement of Citizenship (CAC) testimony on citizenship education follows a general overview of the conference proceedings. A set of mandates for…

  19. Lei da Palmada: algumas considerações

    Directory of Open Access Journals (Sweden)

    Raymundo de Lima

    2012-03-01

    Full Text Available Denominada pela imprensa de “Lei da Palmada”, foi aprovada pela Comissão Especial da Câmara dos Deputados, no final de 2011. A Lei visa proibir castigos físicos às crianças e adolescentes pelos pais ou responsáveis. Ela faz emendas ao Estatuto da Criança e do Adolescente (ECA, de 1990, que já se referia aos “maus tratos”, mas agora dá ênfase ao castigo físico como “ação de natureza disciplinar ou punitiva com o uso de força física que resulte em sofrimento ou lesão”. Portanto, no entendimento da comissão, a palmada é considerada castigo físico.

  20. As leis da natureza e os casos de Tooley

    Directory of Open Access Journals (Sweden)

    Rodrigo Reis Lastra Cid

    2013-06-01

    Full Text Available Os objetivos deste artigo são: (1 apresentar quatro teorias com relação à natureza das leis naturais, (2 mostrar que apenas uma delas é capaz de responder satisfatoriamente aos Casos de Tooley e (3 indicar por que tais casos são relevantes para a nossa ontologia. Estes objetivos são importantes, pois o conceito de "lei natural" é utilizado em muitos, se não todos, os domínios das ciências e em muitos domínios da filosofia; e, se tais casos forem possíveis, eles serão situações que precisariam ser adequadamente descritas. Se uma e apenas uma teoria puder descrever tais casos adequadamente, haverá fortes razões para preferir tal teoria frente às outras.

  1. Co-ordinate regulation of lactate metabolism genes in yeast: the role of the lactate permease gene JEN1.

    Science.gov (United States)

    Lodi, T; Fontanesi, F; Guiard, B

    2002-01-01

    In the yeast Saccharomyces cerevisiae, the first step in lactate metabolism is its transport across the plasma membrane, a proton symport process mediated by the product of the gene JEN1. Under aerobic conditions, the expression of JEN1 is regulated by the carbon source: the gene is repressed by glucose and induced by non-fermentable substrates. JEN1 expression is also controlled by oxygen availability, but is unaffected by the absence of haem biosynthesis. JEN1 is negatively regulated by the repressors Mig1p and Mig2p, and requires Cat8p for full derepression. In this report we demonstrate that, in addition to these regulators, the Hap2/3/4/5 complex interacts specifically with a CAAT-box element in the JEN1 promoter, and acts to derepress JEN1 expression. We also provide evidence for transcriptional stimulation of JEN1 by the protein kinase Snf1p. Data are presented which provide a better understanding of the molecular mechanisms implicated in the co-regulation of genes involved in the metabolism of lactate.

  2. Contração de Lorentz, lei de Gauss e lei de Ampère

    Directory of Open Access Journals (Sweden)

    Ortiz Olivia

    2003-01-01

    Full Text Available Mostramos como obter a expressão para a contração de Lorentz dos comprimentos, a partir das leis de Gauss e Ampère, sem qualquer conhecimento da teoria da relatividade especial de Einstein. Mostramos em seguida que tal resultado é consistente com a transformação relativística dos campos elétrico e magnético.

  3. Gode råd til KU om bæredygtig omstilling

    DEFF Research Database (Denmark)

    Lund, Jens Friis

    2016-01-01

    I gennemsnit flyver alle KU-ansatte retur til Cairo årligt. KU's stigende internationalisering skader klimaet, og det kræver bæredygtig omstilling.......I gennemsnit flyver alle KU-ansatte retur til Cairo årligt. KU's stigende internationalisering skader klimaet, og det kræver bæredygtig omstilling....

  4. Eesti esinumber Jens Salumäe : mul hakkas töötahe kaduma / Deivil Tserp

    Index Scriptorium Estoniae

    Tserp, Deivil, 1968-

    2007-01-01

    Eesti Suusaliidu juhid lähtusid suusahüppaja Jens Salumäe soovist ja kutsusid koondise peatreeneriks tema soomlasest abilise Sami Leskineni. Kommenteerib suusahüppekoondise peatreeneri kohalt taandunud Hillar Hein

  5. Calculations of Changes in Reactivity during some regular periods of operation of JEN-1 MOD Reactor

    International Nuclear Information System (INIS)

    Alcala Ruiz, F.

    1973-01-01

    By a Point-Reactor model and Perturbation Theory, changes in reactivity during some regular operating periods of JEN-1 MOD Reactor have been calculated and compared with available measured values. they were in good agreement. Also changes in reactivity have been calculated during operations at higher power levels than the present one, concluding some practical consequences for the case of increasing the present power of this reactor. (Author)

  6. GPM, DPR Level 2A Ku Precipitation V03

    Data.gov (United States)

    National Aeronautics and Space Administration — The 2AKu algorithm provides precipitation estimates from the Ku radar of the Dual-Frequency Precipitation Radar on the core GPM spacecraft. The product contains one...

  7. O contrato-lei no direito do trabalho mexicano

    Directory of Open Access Journals (Sweden)

    Olga Maria Boschi Aguiar de Oliveira

    2003-12-01

    Full Text Available O presente artigo trata da temáticado Contrato-Lei no Direito do trabalhoMexicano, que na doutrina respectiva éconhecido como Contrato Coletivo Obrigatório.Apesar da diferença de nomenclaturaa legislação trabalhista brasileira tambéminseriu este instituto com a denominaçãode convenção coletiva de trabalho. Uma dasdiferenças específicas entre o institutoadotado pelas leis mexicanas e brasileirasdiz respeito a competência do PoderExecutivo Federal no México para promulgaro decreto respectivo. Porém, a distinçãomais importante refere-se à competência doPresidente da República ou os Governadoresdos Estados, no México, para transformaruma convenção coletiva em Contrato-Lei.The present article is about thetheme of the Contract-Law as part of theMexican Labor Law, which is known as aMandatory Collective Contractin therespective doctrine. In spite of the differencein nomenclature, the Brazilian LaborLegislation also refers to this institute as thecollective labor convention. One of the majordifferences between the institute adopted bythe Mexican and the Brazilian Laws consistsof the competence of the Federal ExecutivePower in Mexico to promulgate therespective decree. However, the mostimportant distinction refers to thecompetence of the President of the Republicor the State Governors, in Mexico, to turn acollective convention into a Contract-Law.

  8. Correlation in chicken between the marker LEI0258 alleles and Major Histocompatibility Complex sequences

    DEFF Research Database (Denmark)

    Chazara, Olympe; Juul-Madsen, Helle Risdahl; Chang, Chi-Seng

    Background The LEI0258 marker is located within the B region of the chicken Major Histocompatibility Complex (MHC), and is surprisingly well associated with serology. Therefore, the correlation between the LEI0258 alleles and the MHC class I and the class II alleles at the level of sequences is w...

  9. Renewal of KU-FEL Facility

    CERN Document Server

    Kii, Toshiteru; Masuda, Kai; Murakami, Shio; Ohgaki, Hideaki; Yamazaki, Tetsuo; Yoshikawa, Kiyoshi; Zen, Heishun

    2004-01-01

    Users demands to a high power tunable IR laser are increasing in Japan in energy-related science, such as basic study of high-efficiency solar cells, generation of new energy source of alcohol and/or H2 from polluted gas, and separation of DNA and/or RNA. To satisfy these demands, we decided to renew our FEL facility more user friendly and to operate more flexibly. Construction and fundamental studies on the KU-FEL have been carried out at a building of Institute of Chemical Research where few other accelerators are operating. Therefore, available machine time for our experiments is quite limited. We are now modifying the room by adding concrete walls of 2-m thickness and some space for users will be available. The present FEL system will be moved to the room A photocathode RF-gun system will be nearly added to the system and the present thermionic RF-gun will be used ternatively according to the demands of users. The photocathode material will be Cs2Te. The room with the shielding will be completed in June, ...

  10. Fatores motivacionais de jovens atletas de vôlei

    Directory of Open Access Journals (Sweden)

    Lívia Tavares da Silva Campos

    2011-06-01

    Full Text Available O estudo objetivou identificar o quanto os fatores motivacionais determinam a permanência de jovens atletas no voleibol de alto nível e compará-los quanto ao gênero e categoria. A coleta de dados foi realizada por meio da aplicação do questionário de Escala de Motivos para a Prática Esportiva (EMPE a 96 jovens atletas de vôlei de quadra (46 meninas e 50 meninos. Os fatores que mais motivaram os atletas para a prática do vôlei foram: aperfeiçoamento técnico, saúde e afiliação. Na comparação quanto ao gênero, com exceção dos fatores saúde e status, as atletas apresentaram maiores índices de motivação do que os atletas. Comparando os fatores motivacionais segundo a categoria, todos os itens analisados, exceto afiliação, motivam da mesma forma os atletas.

  11. Spectroscopic system for impurity measurements in the TJ-1 Tokamak of JEN; Un sistema espectroscopico para medidas de impurezas en el Tokamak TJ-1 de la JEN

    Energy Technology Data Exchange (ETDEWEB)

    Navas, G; Zurro, B

    1982-07-01

    we describe a spectroscopic system with spatial resolution capability that has been configured for plasma diagnostic in the TJ-1 Tokamak of JEN. The experimental system, based on a one meter monochromator, has been absolutely calibrated using a tungsten-halogen lamp. The calibration procedures and the absolute spectral sensitivity are presented as well as its dependence with the polarization. A simplified spectroscopic model of the radiation emitted by the intrinsic plasma impurities (C, 0, . . . ) has been developed. A one dimensional model of the temporal evolution of various ionization stages in coronal equilibrium is used to predict the electron temperature and impurity concentration. This model has been applied to experimental data from several Tokamaks. (Author) 23 refs.

  12. Discovery and characterization of Ku acetylation in Mycobacterium smegmatis.

    Science.gov (United States)

    Zhou, Ying; Chen, Tao; Zhou, Lin; Fleming, Joy; Deng, Jiaoyu; Wang, Xude; Wang, Liwei; Wang, Yingying; Zhang, Xiaoli; Wei, Wenjing; Bi, Lijun

    2015-03-01

    Lysine acetylation is an important post-translational modification and is known to regulate many eukaryotic cellular processes. Little, however, is known about acetylated proteins in prokaryotes. Here, using immunoblotting, mass spectrometry and mutagenesis studies, we investigate the acetylation dynamics of the DNA repair protein Ku and its relationship with the deacetylase protein Sir2 and the non-homologous end joining (NHEJ) pathway in Mycobacterium smegmatis. We report that acetylation of Ku increases with growth, while NHEJ activity decreases, providing support for the hypothesis that acetylation of Ku may be involved in the DNA damage response in bacteria. Ku has multiple lysine sites. Our results indicate that K29 is an important acetylation site and that deficiency of Sir2 or mutation of K29 affects the quantity of Ku and its acetylation dynamics. Our findings expand knowledge of acetylation targets in prokaryotes and indicate a new direction for further research on bacterial DNA repair mechanisms. © FEMS 2014. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  13. Ku-pa-ro en las tablillas de Cnoso

    Directory of Open Access Journals (Sweden)

    José L. Melena

    1974-12-01

    Full Text Available This paper is intended to be a comprehensive analysis of the evidence of ku-pa-ro in the Knossos Linear B tablets. Its main purpose is to set up the importance of such aromatic plant in the Mycenaean economy at Knossos and to identify what kind of sedge was concealed under the name ku-pa-ro and what part of the plant was used and for what purposes. What it is stressed is the usage of the Cyperus rotundus L. (i. e. the ku-pa-ro in the industry of perfumes and as a food additive as well. What is inferred from the discussion on the evidence of ku-pa-ro issues a series of valuable data concerning the localization of certain place-names in the map of Crete, and concerning the explanation of ideogram *171. The high qualities of ku-pa-ro preserved in the tablets lead the author to assume that such a plant was cultivated in Crete and was one of the main aromatic plants used by the Mycenaeans in the making of perfumes.

  14. Expression of Ku correlates with radiation sensitivities in the head and neck cancer cell lines

    International Nuclear Information System (INIS)

    Lee, Sang Wook; Yu, Eun Sil; Yi, So Lyoung; Son, Se Hee; Kim, Jong Hoon; Ahn, Seung Do; Shin, Seong Soo; Choi, Eun Kyung

    2004-01-01

    DNA-dependent protein kinase (DNA-PK) is a serine/threonine kinase consisting of a 470 kDa catalytic subunit (DNA-PKcs) and a heterodimeric regulatory complex, called Ku, which is composed of 70 kDa (Ku 70) and 86 kDa (Ku 80) proteins. The DNA-PK has been shown to play a pivotal role in rejoining DNA double-strand-breaks (dsb) in mammalian cells. The purpose of this study is to examine the relationship between the level of Ku expression and radiation sensitivity. Nine head and neck, cancer cell lines showed various intrinsic radiation sensitivities. Among the nine, AMC-HN-3 cell was the most sensitive for X-ray irradiation and AMC-HN-9 cell was the most resistance. The most sensitive and resistant cell lines were selected and the test sensitivity of radiation and expression of Ku were measured. Radiation sensitivity was obtained by colony forming assay and Ku protein expression using Western blot analysis. Ku80 increased expression by radiation, wheras Ku70 did not. Overexpression of Ku80 protein increased radiation resistance in AMC-HN9 cell line. There was a correlation between Ku80 expression and radiation resistance. Ku80 was shown to play an important role in radiation damage response. Induction of Ku80 expression had an important role in DNA damage repair by radiation. Ku80 expression may be an effective predictive assay of radiosensitivity on head and neck cancer

  15. Levey-Jennings Analysis Uncovers Unsuspected Causes of Immunohistochemistry Stain Variability.

    Science.gov (United States)

    Vani, Kodela; Sompuram, Seshi R; Naber, Stephen P; Goldsmith, Jeffrey D; Fulton, Regan; Bogen, Steven A

    Almost all clinical laboratory tests use objective, quantitative measures of quality control (QC), incorporating Levey-Jennings analysis and Westgard rules. Clinical immunohistochemistry (IHC) testing, in contrast, relies on subjective, qualitative QC review. The consequences of using Levey-Jennings analysis for QC assessment in clinical IHC testing are not known. To investigate this question, we conducted a 1- to 2-month pilot test wherein the QC for either human epidermal growth factor receptor 2 (HER-2) or progesterone receptor (PR) in 3 clinical IHC laboratories was quantified and analyzed with Levey-Jennings graphs. Moreover, conventional tissue controls were supplemented with a new QC comprised of HER-2 or PR peptide antigens coupled onto 8 μm glass beads. At institution 1, this more stringent analysis identified a decrease in the HER-2 tissue control that had escaped notice by subjective evaluation. The decrement was due to heterogeneity in the tissue control itself. At institution 2, we identified a 1-day sudden drop in the PR tissue control, also undetected by subjective evaluation, due to counterstain variability. At institution 3, a QC shift was identified, but only with 1 of 2 controls mounted on each slide. The QC shift was due to use of the instrument's selective reagent drop zones dispense feature. None of these events affected patient diagnoses. These case examples illustrate that subjective QC evaluation of tissue controls can detect gross assay failure but not subtle changes. The fact that QC issues arose from each site, and in only a pilot study, suggests that immunohistochemical stain variability may be an underappreciated problem.

  16. Elbereth. A soubroutine library for graphic representation from J.E.N. Fusion Division

    International Nuclear Information System (INIS)

    Guasp, J.

    1981-01-01

    A library for graphic representation, named Elbereth, has been built, all the subroutines have been written in Fortran-V for the Univac-1100/80 computer from J.E.N. and are able to produce drawing on the Calcomp-936 plotter, as well as with the printers and on the UTS-400 terminal screen. The library can yield two or three-dimensional plots as well as level lines, all of them under free format or in several standard ones either. It allows to be used on a simplified way by direct reading from a file. It has been constructed too with a flexible structure to allow forthcoming extensions. (author)

  17. Regulation of homologous recombination repair protein Rad51 by Ku70

    International Nuclear Information System (INIS)

    Du Liqing; Liu Qiang; Wang Yan; Xu Chang; Cao Jia; Fu Yue; Chen Fenghua; Fan Feiyue

    2013-01-01

    Objective: To explore the regulative effect of non-homologous end joining (NHEJ)protein Ku70 on homologous recombination repair protein Rad51, and to investigate the synergistic mechanism of homologous recombination repair in combination with NHEJ. Methods: Observed Rad51 protein expression after transfect Ku70 small interfering RNA or Ku70 plasmid DNA into tumor cells using Western blot. Results: Expression of Rad51 was obviously reduced after pretreated with Ku70 small interfering RNA. And with the increasing expression of Ku70 protein after transfection of Ku70 plasmid DNA PGCsi3.0-hKu70 into tumor cell lines, the Rad51 protein expression was increased. Conclusion: Ku70 protein has regulating effect on gene expression of Rad51, and it might participate in the collaboration between homologous recombination repair and NHEJ. (authors)

  18. Interspecific variation of intracellular localization and postirradiation movement of Ku70-protein in fibroblastic cells

    International Nuclear Information System (INIS)

    Endoh, Daiji; Hayashi, Masanobu; Okui, Toyo; Kawase, Shiro; Kon, Yasushiro

    2003-01-01

    Ku (Ku70 and Ku80) Proteins are known as components of DNA-dependent protein kinase (DNA-PK) and play an important role for DNA repair. We previously reported that more than 70% of Ku proteins were located in cytoplasm of rat cells, the Ku proteins moved into nuclei of normal rat cells after X-irradiation, Ku proteins also moved into nuclei after X-irradiation but were not retained in nucleus of radiosensitive LEC rat cells. While reports have been shown about mechanisms on nuclear localization of Ku proteins, how Ku proteins export from nucleus is poorly understood. Here we show that C-terminal region of Ku70 protein is important for its cytoplasmic localization. When transfected into LEC rat cells, exogenous intact Ku70 (1-609) tagged with enhanced green fluorescent protein (EGFP-Ku70) localized mainly in the cytoplasm, whereas C-terminal-deletion mutant of Ku70 (1-593) tagged with EGFP (EGFP-Ku70D) was mainly localized in the nucleus. After X-irradiation, the endogenous intact EGFP-Ku70 once moved into nucleus, but returned into the cytoplasm. On the other hand, EGFP-Ku70D was retained in nucleus for two hours after X-irradiation. These results suggest that C-terminal region of Ku70 is included in the postirradiation nuclear export. Next, we investigated the intracellular localization of Ku70 proteins and the movement after X-irradiation of fibroblastic cells prepared from some mammalian species. Ku70 proteins were localized in nucleus and the postirradiation-extranuclear transport was not observed in human and African green monkey cells. On the other hand, Ku70 proteins were mainly localized in cytoplasm and moved into nucleus in mouse, Chinese hamster, Golden hamster, cotton rat, squirrel, cat and dog cells. These results may show that alternatively Ku70 protein is localized in the cytoplasm or nucleus depends on species and translocation of cytoplasmic Ku70 into nucleus is a response against low dose irradiation in fibroblasts of rodents, cats and dogs

  19. A primeira Lei de Newton: uma abordagem didática

    OpenAIRE

    da Silva, Saulo Luis Lima

    2018-01-01

    Resumo No estudo da mecânica Newtoniana o essencial é a compreensão das leis de Newton em profundidade. Se isso acontecer, ficará fácil perceber que todos os outros fenômenos a serem estudados são consequências dessas três leis básicas do movimento formuladas por Isaac Newton. Dentre elas, a primeira lei de Newton, conhecida como lei da Inércia, é a de maior complexidade filosófica e a menos compreendida pelos alunos ao saírem de um curso de física básica. Não é incomum encontrar alunos descr...

  20. Lei da Mata Atlântica: Retrocesso ambiental

    Directory of Open Access Journals (Sweden)

    Roberto Varjabedian

    2010-01-01

    Full Text Available A Lei Federal n.11.428/06 e o Decreto Federal n.6.660/08, quando comparados ao Decreto Federal n.750/93, contêm várias alterações ambientalmente nocivas, configurando um retrocesso para a proteção da Mata Atlântica. Quanto à Lei n.11.428, verifica-se, por exemplo, que o estágio médio de regeneração recebeu um tratamento distinto em relação à vegetação primária e em estágio avançado, tendo sua proteção desguarnecida; e que os artigos 30 e 31, associados aos artigos 11, 12 e 17, abrem novas possibilidades para supressão de vegetação nativa de florestas tanto em estágio avançado como em estágio médio de regeneração. O Decreto n.6.660 permite, por exemplo, a exploração de madeira e lenha em propriedades rurais sem controle dos órgãos competentes.The Federal Law n.11.428/06 and the Federal Decree n.6.660/08 compared to the Federal Decree n.750/93 contain some environmentally harmful flexibilities and changes, configuring a setback for the Atlantic Rainforest protection. In the Law n.11.428, it's verified, for example, a different treatment for Rainforest in intermediate stage of regeneration in relation to advanced stage or climax, and the Articles 30 and 31, associated with Articles 11, 12 and 17, open new possibilities for deforestation, both forest in an advanced stage, as in the intermediate stage of regeneration. The Decree n.6.660 allows, for example, the eventual exploration of timber and firewood in rural properties without control of the competent agencies.

  1. Ku70 inhibits gemcitabine-induced DNA damage and pancreatic cancer cell apoptosis

    International Nuclear Information System (INIS)

    Ma, Jiali; Hui, Pingping; Meng, Wenying; Wang, Na; Xiang, Shihao

    2017-01-01

    The current study focused on the role of Ku70, a DNA-dependent protein kinase (DNA-PK) complex protein, in pancreatic cancer cell resistance to gemcitabine. In both established cell lines (Mia-PaCa-2 and PANC-1) and primary human pancreatic cancer cells, shRNA/siRNA-mediated knockdown of Ku70 significantly sensitized gemcitabine-induced cell death and proliferation inhibition. Meanwhile, gemcitabine-induced DNA damage and subsequent pancreatic cancer cell apoptosis were also potentiated with Ku70 knockdown. On the other hand, exogenous overexpression of Ku70 in Mia-PaCa-2 cells suppressed gemcitabine-induced DNA damage and subsequent cell apoptosis. In a severe combined immune deficient (SCID) mice Mia-PaCa-2 xenograft model, gemcitabine-induced anti-tumor activity was remarkably pontificated when combined with Ku70 shRNA knockdown in the xenografts. The results of this preclinical study imply that Ku70 might be a primary resistance factor of gemcitabine, and Ku70 silence could significantly chemo-sensitize gemcitabine in pancreatic cancer cells. - Highlights: • Ku70 knockdown sensitizes gemcitabine-induced killing of pancreatic cancer cells. • Ku70 knockdown facilitates gemcitabine-induced DNA damage and cell apoptosis. • Ku70 overexpression deceases gemcitabine's sensitivity in pancreatic cancer cells. • Ku70 knockdown sensitizes gemcitabine-induced anti-tumor activity in vivo.

  2. The transport of carboxylic acids and important role of the Jen1p transporter during the development of yeast colonies

    Czech Academy of Sciences Publication Activity Database

    Paivo, S.; Strachotová, Dita; Kučerová, Helena; Hlaváček, Otakar; Mota, A.; Casal, M.; Palková, Z.; Váchová, Libuše

    2013-01-01

    Roč. 454, SEP 2013 (2013), s. 551-558 ISSN 0264-6021 R&D Projects: GA ČR GA204/08/0718 Institutional support: RVO:61388971 Keywords : ammonia production * Jen1p protein * monocarboxylic acid import Subject RIV: CE - Biochemistry Impact factor: 4.779, year: 2013

  3. Jens Baggesen voyageur en France. Un regard amusé et satirique sur la France révolutionnaire

    DEFF Research Database (Denmark)

    Schøsler, Jørn

    2011-01-01

    Jens Baggesens rejse i det revolutionære Frankrig i januar 1790 viser hans humor og satiriske gemyt i hans syn på franskmændene. Hans humoristiske vinkel afslører et manglende politisk engagement i de dramatiske begivenheder....

  4. Balanço Sobre a Lei Maria Da Penha

    Directory of Open Access Journals (Sweden)

    Cecilia Maria Bacellar Sardenberg

    2015-05-01

    Full Text Available Em novembro de 2004, há pouco mais de uma década, chegava ao Congresso Nacional, por intermédio da Secretaria Especial de Políticas para Mulheres (SPM, um projeto de lei de enfrentamento à violência conjugal, doméstica e familiar contra mulheres bastante ambicioso. Fruto de mais de três décadas de lutas dos movimentos feministas no país e, mais especificamente, dos esforços de um consórcio de organizações feministas em articulação com a SPM, o projeto respondia às recomendações tanto da Plataforma Política Feminista de 2002, quanto das Convenções CEDAW (Convenção sobre a Eliminação de Todas as Formas de Discriminação contra a Mulher e Belém do Pará, assinadas e ratificadas pelo Estado Brasileiro.

  5. Review: Jens Brockmeier (2015. Beyond the Archive: Memory, Narrative, and the Autobiographical Process

    Directory of Open Access Journals (Sweden)

    Lucas Bietti

    2016-08-01

    Full Text Available Jens BROCKMEIER's new book proposes a very provocative aim for memory studies: "[T]o radically re-think our very idea of memory and challenge the notions of remembering and forgetting that we have taken for granted" (p.vii. The main target for the author's critique is the archival model of memory. In order to support his approach, the author provides empirical evidence from the neurosciences, social sciences, and humanities. "Beyond the Archive" represents an innovative contribution to the field of memory studies. It brings together disparate disciplinary fields in a novel and sophisticated fashion with a clear goal in mind: to propose a new model for the analysis of autobiographical remembering. BROCKMEIER's book is a true exercise of multidisciplinary research in action, which is much needed in the current climate of psychological and neuroscientific reductionism in the sciences of memory. URN: http://nbn-resolving.de/urn:nbn:de:0114-fqs160338

  6. Spectroscopic system for impurity measurements in the TJ-1 Tokamak of JEN

    International Nuclear Information System (INIS)

    Navas, G.; Zurro, B.

    1982-01-01

    we describe a spectroscopic system with spatial resolution capability that has been configured for plasma diagnostic in the TJ-1 Tokamak of JEN. The experimental system, based on a one meter monochromator, has been absolutely calibrated using a tungsten-halogen lamp. The calibration procedures and the absolute spectral sensitivity are presented as well as its dependence with the polarization. A simplified spectroscopic model of the radiation emitted by the intrinsic plasma impurities (C, 0, . . . ) has been developed. A one dimensional model of the temporal evolution of various ionization stages in coronal equilibrium is used to predict the electron temperature and impurity concentration. This model has been applied to experimental data from several Tokamaks. (Author) 23 refs

  7. KEHONKUVA JA MEDIA : 9.-luokkalaisten tyttöjen kehonkuva ja median vaikutus siihen

    OpenAIRE

    Vainionpää, Charlotta; Koski, Riikka

    2016-01-01

    Tämän tutkimuksen aiheena oli kehonkuva ja media: 9.-luokkalaisten tyttöjen kehonkuva ja median vaikutus siihen. Tutkimuksen tarkoituksena oli selvittää minkälaisena tytöt kokevat oman kehonkuvansa, minkälaisia ulkonäköpaineita tytöillä on ja miten media vaikuttaa heidän kehonkuvaansa. Työn teoreettisessa viitekehyksessä pääkäsitteet olivat nuoruus, kehonkuva ja media. Nuoruus-osiossa käsiteltiin nuoruuden määrittelyn lisäksi murrosikää ja murrosiän fyysisiä sekä psyykkisiä muutoksia. Keh...

  8. Experience at J.E.N. with electrochemical cells for measurement of oxygen activity

    International Nuclear Information System (INIS)

    La Torre, M.de; Lapena, J.; Couchoud, M.

    1981-01-01

    The experience gained at the J.E.N. with oxygen meters since 1974 till 1980 is presented. Thirteen oxygen meters were tested. Eight with Cu/Cu/ 2 O reference electrode and the rest with Sn/SnO 2 , and two types of electrolyte tube produced by zircoa under specifications development by UNC and HEDL. The cells equiped with Cu/Cu 2 O showed an anomalous performance giving an e.m.f. higher than the theoretical value, and one of them was in close agreement to cells using air as reference electrode. An explanation is given. The performance of the cells with Sn/SnO 2 is in good agreement with those obtained in others laboratories. To calculate the theoretical value, it has derived a correlation colubility for oxygen with 262 data obtained by the vacuum distillation method. Various recommendations are pointed out on the future development of the oxygen meters to improve its performance. (author)

  9. Experience at JEN with electrochemical cells for measurement of oxygen activity in liquid sodium

    International Nuclear Information System (INIS)

    De la Torre, M.; Lapena, J.; Couchoud, M.

    1981-01-01

    This report presents the experience gained at the JEN with Oxygen Meters since 1974 till 1980. Thirteen O.H. were tested. Eight with Cu/Cu 2 O reference electrode and the rest with Sn/SnO 2 , and two types of electrolyte tube produced by Zircon under specifications development by UNC and HEDL. The cells equipped with Cu/Cu 2 O showed an anomalous performance giving an e.m.f. higher than the theoretical value, and one of them was in close agreement cells using air as reference electrode. An explanation is given. The performance of the cells with Sn/SnO 2 is in good agreement with those obtained in others laboratories. To calculate the theoretical value, it has derived a correlation solubility for oxygen with 262 data obtained by the vacuum distillation on method. Various recommendations are pointed out on the future development of the O.H. to improve its performance. (Author) 25 refs

  10. The effect of some organic substances on the mycelium of the fungus Ustilago nuda (Jens.) Rostr.

    Science.gov (United States)

    Krátká, J

    1976-01-01

    Research was performed for studying the effect of some organic compounds, considered by many authors as the products ob barley seed metabolism generated after anaerobic seed treatment, on the mycelium of the fungus Ustilago nuda (Jens.) Rostr. The author examined the effectiveness of ethylacohol, acetaldehyde, acetic acid, succinic acid, lactic acid, and hydroquinone in concentrations from 1 M to 10(-6) M, and the effectiveness of extracts from disinfected seeds in doses from 10 g to 0.001 g/l. The effect of the mentioned solutions was examined as exerted on the growth of dicaryotic mycelium and on the growth of the haploid promycelium of the fungus. The dicaryotic mycelium of Ustilago nuda (Jens.) Rostr. was cultivated on potato agar with benzoic acid. The presence of the acid prevents mitosis, and the chlamydospores germinate on the nutritive medium with two fibres having binuclear cells. The haploid promycelium was cultivated on potato agar; chlamydospores germinated with one four-cell fibre, and individual cells are mononuclear and haploid. Only later, a dicarytic mycelium is created in a complex process. In all the substances used, the concentration of 1 M was found to stop further growth of mycelium. The concentration of 10(-1) M of acetic acid and hydroquinone also stopped growth, the same concentration of acetaldehyde, lactic acid, succinic acid, ethylacohol stimulated mycelium growth in comparison with the control. The concentration of 10(-6) M stimulated mycelium growth in a majority of cases. Extracts from disinfected seeds did not influence mycelium growth significantly in all cases in comparison with the control. The results were similar in the two types of mycelium.

  11. Impossibilidade de alteração de lei complementar por lei ordinária em matéria tributária

    Directory of Open Access Journals (Sweden)

    Marcelo de Lima Castro Diniz

    2000-03-01

    Full Text Available Usually the legislator controls a specific subject through a complementary law, although it can be done through a ordinary law, which is different concerning the legislative process, mainly on the quorum matter. A law with these characteristics must be considered complementary law, so that its modification is only possible by a norm on the same level. According to the principles of “more value legitimatory” and liberty of conformation of the legislator in his legislative activity.É comum que o legislador regule um determinado assunto por meio de lei complementar, embora pudesse fazê-lo através de lei ordinária, cujo processo legislativo é diferente, sobretudo pela questão do quorum. Uma lei com essas características deve ser considerada lei complementar, decorrendo daí que sua modificação apenas é possível por norma do mesmo escalão, em face dos princípios da mais valia legitimatória e da liberdade de conformação do legislador na atividade legislativa.

  12. Interaction of caveolin-1 with Ku70 inhibits Bax-mediated apoptosis.

    Directory of Open Access Journals (Sweden)

    Huafei Zou

    Full Text Available Caveolin-1, the structural protein component of caveolae, acts as a scaffolding protein that functionally regulates signaling molecules. We show that knockdown of caveolin-1 protein expression enhances chemotherapeutic drug-induced apoptosis and inhibits long-term survival of colon cancer cells. In vitro studies demonstrate that caveolin-1 is a novel Ku70-binding protein, as shown by the binding of the scaffolding domain of caveolin-1 (amino acids 82-101 to the caveolin-binding domain (CBD of Ku70 (amino acids 471-478. Cell culture data show that caveolin-1 binds Ku70 after treatment with chemotherapeutic drugs. Mechanistically, we found that binding of caveolin-1 to Ku70 inhibits the chemotherapeutic drug-induced release of Bax from Ku70, activation of Bax, translocation of Bax to mitochondria and apoptosis. Potentiation of apoptosis by knockdown of caveolin-1 protein expression is greatly reduced in the absence of Bax expression. Finally, we found that overexpression of wild type Ku70, but not a mutant form of Ku70 that cannot bind to caveolin-1 (Ku70 Φ→A, limits the chemotherapeutic drug-induced Ku70/Bax dissociation and apoptosis. Thus, caveolin-1 acts as an anti-apoptotic protein in colon cancer cells by binding to Ku70 and inhibiting Bax-dependent cell death.

  13. Ku must load directly onto the chromosome end in order to mediate its telomeric functions.

    Directory of Open Access Journals (Sweden)

    Christopher R Lopez

    2011-08-01

    Full Text Available The Ku heterodimer associates with the Saccharomyces cerevisiae telomere, where it impacts several aspects of telomere structure and function. Although Ku avidly binds DNA ends via a preformed channel, its ability to associate with telomeres via this mechanism could be challenged by factors known to bind directly to the chromosome terminus. This has led to uncertainty as to whether Ku itself binds directly to telomeric ends and whether end association is crucial for Ku's telomeric functions. To address these questions, we constructed DNA end binding-defective Ku heterodimers by altering amino acid residues in Ku70 and Ku80 that were predicted to contact DNA. These mutants continued to associate with their known telomere-related partners, such as Sir4, a factor required for telomeric silencing, and TLC1, the RNA component of telomerase. Despite these interactions, we found that the Ku mutants had markedly reduced association with telomeric chromatin and null-like deficiencies for telomere end protection, length regulation, and silencing functions. In contrast to Ku null strains, the DNA end binding defective Ku mutants resulted in increased, rather than markedly decreased, imprecise end-joining proficiency at an induced double-strand break. This result further supports that it was the specific loss of Ku's telomere end binding that resulted in telomeric defects rather than global loss of Ku's functions. The extensive telomere defects observed in these mutants lead us to propose that Ku is an integral component of the terminal telomeric cap, where it promotes a specific architecture that is central to telomere function and maintenance.

  14. Ku must load directly onto the chromosome end in order to mediate its telomeric functions.

    Science.gov (United States)

    Lopez, Christopher R; Ribes-Zamora, Albert; Indiviglio, Sandra M; Williams, Christopher L; Haricharan, Svasti; Bertuch, Alison A

    2011-08-01

    The Ku heterodimer associates with the Saccharomyces cerevisiae telomere, where it impacts several aspects of telomere structure and function. Although Ku avidly binds DNA ends via a preformed channel, its ability to associate with telomeres via this mechanism could be challenged by factors known to bind directly to the chromosome terminus. This has led to uncertainty as to whether Ku itself binds directly to telomeric ends and whether end association is crucial for Ku's telomeric functions. To address these questions, we constructed DNA end binding-defective Ku heterodimers by altering amino acid residues in Ku70 and Ku80 that were predicted to contact DNA. These mutants continued to associate with their known telomere-related partners, such as Sir4, a factor required for telomeric silencing, and TLC1, the RNA component of telomerase. Despite these interactions, we found that the Ku mutants had markedly reduced association with telomeric chromatin and null-like deficiencies for telomere end protection, length regulation, and silencing functions. In contrast to Ku null strains, the DNA end binding defective Ku mutants resulted in increased, rather than markedly decreased, imprecise end-joining proficiency at an induced double-strand break. This result further supports that it was the specific loss of Ku's telomere end binding that resulted in telomeric defects rather than global loss of Ku's functions. The extensive telomere defects observed in these mutants lead us to propose that Ku is an integral component of the terminal telomeric cap, where it promotes a specific architecture that is central to telomere function and maintenance.

  15. Os Paradigmas da Lei no Pensamento de Hannah Arendt

    Directory of Open Access Journals (Sweden)

    Gustavo Jaccottet Freitas

    2017-02-01

    Full Text Available A legitimidade jurídica dos atos políticos é vinculada ao problema da Lei. Os elementos filosóficos do que diz respeito à legitimidade jurídica dos atos políticos são constantemente tratados nas obras de Hannah Arendt (1906-1975, como Origens do Totalitarismo, Sobre a Revolução e Eichmann em Jerusalém, além de estarem presentes no pensamento de outros autores, como Austin e Hart. A fim de contextualizar o pensamento da Autora, é necessário ter por conta que o Regime Nazista foi responsável pela prática de crimes contra a humanidade cujos precedentes não podem ser encontrados em nenhum documento histórico. Os delitos cometidos pelos Nazistas, todavia, não eram novidade. O genocídio, a tortura e a privação imotivada da liberdade já eram praticadas antes mesmo da antiguidade, porém não da maneira como o Regime Totalitário fez uso dessas ações ilícitas. Um único regime político foi capaz de conjugar uma série de práticas contrárias à dignidade da pessoa humana, de forma a negar a própria personalidade jurídica do ser humano. A engenharia usada para criar fábricas de morte, os sistemas de logística para o transporte de pessoas para essas fábricas e a maneira de como elas eram exterminadas e depois esquecidas tinha uma função institucional no corpo político guiado por Adolf Hitler.

  16. Design of a Ku band miniature multiple beam klystron

    Energy Technology Data Exchange (ETDEWEB)

    Bandyopadhyay, Ayan Kumar, E-mail: ayan.bandyopadhyay@gmail.com; Pal, Debasish; Kant, Deepender [Microwave Tubes Division, CSIR-CEERI, Pilani, Rajasthan-333031 (India); Saini, Anil; Saha, Sukalyan; Joshi, Lalit Mohan

    2016-03-09

    The design of a miniature multiple beam klystron (MBK) working in the Ku-band frequency range is presented in this article. Starting from the main design parameters, design of the electron gun, the input and output couplers and radio frequency section (RF-section) are presented. The design methodology using state of the art commercial electromagnetic design tools, analytical formulae as well as noncommercial design tools are briefly presented in this article.

  17. 'SON-GO-KU' : a dream of automated library

    Science.gov (United States)

    Sato, Mamoru; Kishimoto, Juji

    In the process of automating libraries, the retrieval of books through the browsing of shelves is being overlooked. The telematic library is a document based DBMS which can deliver the content of books by simulating the browsing process. The retrieval actually simulates the process a person would use in selecting a book in a real library, where a visual presentation using a graphic display is substituted. The characteristics of prototype system "Son-Go-Ku" for such retrieval implemented in 1988 are mentioned.

  18. Ku recruits XLF to DNA double-strand breaks.

    Science.gov (United States)

    Yano, Ken-ichi; Morotomi-Yano, Keiko; Wang, Shih-Ya; Uematsu, Naoya; Lee, Kyung-Jong; Asaithamby, Aroumougame; Weterings, Eric; Chen, David J

    2008-01-01

    XRCC4-like factor (XLF)--also known as Cernunnos--has recently been shown to be involved in non-homologous end-joining (NHEJ), which is the main pathway for the repair of DNA double-strand breaks (DSBs) in mammalian cells. XLF is likely to enhance NHEJ by stimulating XRCC4-ligase IV-mediated joining of DSBs. Here, we report mechanistic details of XLF recruitment to DSBs. Live cell imaging combined with laser micro-irradiation showed that XLF is an early responder to DSBs and that Ku is essential for XLF recruitment to DSBs. Biochemical analysis showed that Ku-XLF interaction occurs on DNA and that Ku stimulates XLF binding to DNA. Unexpectedly, XRCC4 is dispensable for XLF recruitment to DSBs, although photobleaching analysis showed that XRCC4 stabilizes the binding of XLF to DSBs. Our observations showed the direct involvement of XLF in the dynamic assembly of the NHEJ machinery and provide mechanistic insights into DSB recognition.

  19. LEI 11.340/2006: SEU CONTEXTO, CONTEÚDO E APLICAÇÃO.

    Directory of Open Access Journals (Sweden)

    Carolina Vicente Bisognin

    2007-12-01

    Full Text Available Entrou em vigor, em setembro de 2006, a lei 11.340/2006, também conhecida como Lei Maria da Penha, em homenagem à senhora que através de suas tragédias pessoais propiciou a elaboração da lei. Tal conjunto normativo é considerado uma forma de discriminação positiva, ao lado de outros marcos regulatórios, como o Estatuto da criança e do Adolescente e Estatuto do Idoso. A nova lei regulamenta os casos de violência doméstica, trazendo diversas mudanças, dentre as quais vale destacar as do processo judicial, do resgate do inquérito policial, do papel participativo da autoridade policial, além das alterações no Código Penal, Código de Processo Penal e Lei de Execução Penal.

  20. Mycobacterium tuberculosis Ku can bind to nuclear DNA damage and sensitize mammalian cells to bleomycin sulfate.

    Science.gov (United States)

    Castore, Reneau; Hughes, Cameron; Debeaux, Austin; Sun, Jingxin; Zeng, Cailing; Wang, Shih-Ya; Tatchell, Kelly; Shi, Runhua; Lee, Kyung-Jong; Chen, David J; Harrison, Lynn

    2011-11-01

    Radiotherapy and chemotherapy are effective cancer treatments due to their ability to generate DNA damage. The major lethal lesion is the DNA double-strand break (DSB). Human cells predominantly repair DSBs by non-homologous end joining (NHEJ), which requires Ku70, Ku80, DNA-PKcs, DNA ligase IV and accessory proteins. Repair is initiated by the binding of the Ku heterodimer at the ends of the DSB and this recruits DNA-PKcs, which initiates damage signaling and functions in repair. NHEJ also exists in certain types of bacteria that have dormant phases in their life cycle. The Mycobacterium tuberculosis Ku (Mt-Ku) resembles the DNA-binding domain of human Ku but does not have the N- and C-terminal domains of Ku70/80 that have been implicated in binding mammalian NHEJ repair proteins. The aim of this work was to determine whether Mt-Ku could be used as a tool to bind DSBs in mammalian cells and sensitize cells to DNA damage. We generated a fusion protein (KuEnls) of Mt-Ku, EGFP and a nuclear localization signal that is able to perform bacterial NHEJ and hence bind DSBs. Using transient transfection, we demonstrated that KuEnls is able to bind laser damage in the nucleus of Ku80-deficient cells within 10 sec and remains bound for up to 2 h. The Mt-Ku fusion protein was over-expressed in U2OS cells and this increased the sensitivity of the cells to bleomycin sulfate. Hydrogen peroxide and UV radiation do not predominantly produce DSBs and there was little or no change in sensitivity to these agents. Since in vitro studies were unable to detect binding of Mt-Ku to DNA-PKcs or human Ku70/80, this work suggests that KuEnls sensitizes cells by binding DSBs, preventing human NHEJ. This study indicates that blocking or decreasing the binding of human Ku to DSBs could be a method for enhancing existing cancer treatments.

  1. Drosophila UTX coordinates with p53 to regulate ku80 expression in response to DNA damage.

    Directory of Open Access Journals (Sweden)

    Chengwan Zhang

    Full Text Available UTX is known as a general factor that activates gene transcription during development. Here, we demonstrate an additional essential role of UTX in the DNA damage response, in which it upregulates the expression of ku80 in Drosophila, both in cultured cells and in third instar larvae. We further showed that UTX mediates the expression of ku80 by the demethylation of H3K27me3 at the ku80 promoter upon exposure to ionizing radiation (IR in a p53-dependent manner. UTX interacts physically with p53, and both UTX and p53 are recruited to the ku80 promoter following IR exposure in an interdependent manner. In contrast, the loss of utx has little impact on the expression of ku70, mre11, hid and reaper, suggesting the specific regulation of ku80 expression by UTX. Thus, our findings further elucidate the molecular function of UTX.

  2. Preclinical evaluation of (111)In-DTPA-INCA-X anti-Ku70/Ku80 monoclonal antibody in prostate cancer.

    Science.gov (United States)

    Evans-Axelsson, Susan; Vilhelmsson Timmermand, Oskar; Welinder, Charlotte; Borrebaeck, Carl Ak; Strand, Sven-Erik; Tran, Thuy A; Jansson, Bo; Bjartell, Anders

    2014-01-01

    The aim of this investigation was to assess the Ku70/Ku80 complex as a potential target for antibody imaging of prostate cancer. We evaluated the in vivo and ex vivo tumor targeting and biodistribution of the (111)In-labeled human internalizing antibody, INCA-X ((111)In-DTPA-INCA-X antibody), in NMRI-nude mice bearing human PC-3, PC-3M-Lu2 or DU145 xenografts. DTPA-conjugated, non-labeled antibody was pre-administered at different time-points followed by a single intravenous injection of (111)In-DTPA-INCA-X. At 48, 72 and 96 h post-injection, tissues were harvested, and the antibody distribution was determined by measuring radioactivity. Preclinical SPECT/CT imaging of mice with and without the predose was performed at 48 hours post-injection of labeled DTPA-INCA-X. Biodistribution of the labeled antibody showed enriched activity in tumor, spleen and liver. Animals pre-administered with DTPA-INCA-X showed increased tumor uptake and blood content of (111)In-DTPA-INCA-X with reduced splenic and liver uptake. The in vitro and in vivo data presented show that the (111)In-labeled INCA-X antibody is internalized into prostate cancer cells and by pre-administering non-labeled DTPA-INCA-X, we were able to significantly reduce the off target binding and increase the (111)In-DTPA-INCA-X mAb uptake in PC-3, PC-3M-Lu2 and DU145 xenografts. The results are encouraging and identifying the Ku70/Ku80 antigen as a target is worth further investigation for functional imaging of prostate cancer.

  3. Preclinical evaluation of 111In-DTPA-INCA-X anti-Ku70/Ku80 monoclonal antibody in prostate cancer

    Science.gov (United States)

    Evans-Axelsson, Susan; Vilhelmsson Timmermand, Oskar; Welinder, Charlotte; Borrebaeck, Carl AK; Strand, Sven-Erik; Tran, Thuy A; Jansson, Bo; Bjartell, Anders

    2014-01-01

    The aim of this investigation was to assess the Ku70/Ku80 complex as a potential target for antibody imaging of prostate cancer. We evaluated the in vivo and ex vivo tumor targeting and biodistribution of the 111In-labeled human internalizing antibody, INCA-X (111In-DTPA-INCA-X antibody), in NMRI-nude mice bearing human PC-3, PC-3M-Lu2 or DU145 xenografts. DTPA-conjugated, non-labeled antibody was pre-administered at different time-points followed by a single intravenous injection of 111In-DTPA-INCA-X. At 48, 72 and 96 h post-injection, tissues were harvested, and the antibody distribution was determined by measuring radioactivity. Preclinical SPECT/CT imaging of mice with and without the predose was performed at 48 hours post-injection of labeled DTPA-INCA-X. Biodistribution of the labeled antibody showed enriched activity in tumor, spleen and liver. Animals pre-administered with DTPA-INCA-X showed increased tumor uptake and blood content of 111In-DTPA-INCA-X with reduced splenic and liver uptake. The in vitro and in vivo data presented show that the 111In-labeled INCA-X antibody is internalized into prostate cancer cells and by pre-administering non-labeled DTPA-INCA-X, we were able to significantly reduce the off target binding and increase the 111In-DTPA-INCA-X mAb uptake in PC-3, PC-3M-Lu2 and DU145 xenografts. The results are encouraging and identifying the Ku70/Ku80 antigen as a target is worth further investigation for functional imaging of prostate cancer. PMID:24982817

  4. Calculations of Changes in Reactivity during some regular periods of operation of JEN-1 MOD Reactor; Calculo de vairaciones de reactividad en algunos periodos regulares de operacion del reactor JEN-1 Mod.

    Energy Technology Data Exchange (ETDEWEB)

    Alcala Ruiz, F

    1973-07-01

    By a Point-Reactor model and Perturbation Theory, changes in reactivity during some regular operating periods of JEN-1 MOD Reactor have been calculated and compared with available measured values. they were in good agreement. Also changes in reactivity have been calculated during operations at higher power levels than the present one, concluding some practical consequences for the case of increasing the present power of this reactor. (Author)

  5. The Ku80 carboxy terminus stimulates joining and artemis-mediated processing of DNA ends

    DEFF Research Database (Denmark)

    Weterings, Eric; Verkaik, Nicole S; Keijzers, Guido

    2008-01-01

    Repair of DNA double-strand breaks (DSBs) is predominantly mediated by nonhomologous end joining (NHEJ) in mammalian cells. NHEJ requires binding of the Ku70-Ku80 heterodimer (Ku70/80) to the DNA ends and subsequent recruitment of the DNA-dependent protein kinase catalytic subunit (DNA-PK(CS)) an......Repair of DNA double-strand breaks (DSBs) is predominantly mediated by nonhomologous end joining (NHEJ) in mammalian cells. NHEJ requires binding of the Ku70-Ku80 heterodimer (Ku70/80) to the DNA ends and subsequent recruitment of the DNA-dependent protein kinase catalytic subunit (DNA......-PK(CS)) and the XRCC4/ligase IV complex. Activation of the DNA-PK(CS) serine/threonine kinase requires an interaction with Ku70/80 and is essential for NHEJ-mediated DSB repair. In contrast to previous models, we found that the carboxy terminus of Ku80 is not absolutely required for the recruitment and activation...... was phosphorylated to normal levels. This resulted in severely reduced levels of Artemis nuclease activity in vivo and in vitro. We therefore conclude that the Ku80 carboxy terminus is important to support DNA-PK(CS) autophosphorylation at specific sites, which facilitates DNA end processing by the Artemis...

  6. Significant improvement of the osseointegration of zirconia dental implants by HS-LEIS analysis

    International Nuclear Information System (INIS)

    Beekmans, H.; Breitenstein, D.; Brongersma, H.H.; Ridder, M. de; Tromp, Th.J.

    2010-01-01

    The use of sintered yttria stabilized zirconia dental implants is a recent development. After initial successes with these new implants a pattern of erratic results emerged. Reliable osseointegration would not always occur. High-sensitivity low energy ion scattering (HS-LEIS) is used to investigate both virgin and rejected implants. The surfaces of the implant are found to be covered with both an organic and inorganic contamination layer. Sterilization does not remove this contamination. Using LEIS as analytic tool a new cleaning process has been developed. Since this cleaning process is in use, the failure rate has dropped to a very low value.

  7. Toward a Pragmatist Epistemology: Arthur O. Lovejoy's and H. S. Jennings's Biophilosophical Responses to Neovitalism, 1909-1914.

    Science.gov (United States)

    Russell, Doug

    2015-01-01

    The sustained interdisciplinary debate about neovitalism between two Johns Hopkins University colleagues, philosopher Arthur O. Lovejoy and experimental geneticist H. S. Jennings, in the period 1911-1914, was the basis for their theoretical reconceptualization of scientific knowledge as contingent and necessarily incomplete in its account of nature. Their response to Hans Driesch's neovitalist concept of entelechy, and his challenge to the continuity between biology and the inorganic sciences, resulted in a historically significant articulation of genetics and philosophy. This study traces the debate's shift of problem-focus away from neovitalism's threat to the unity of science - "organic autonomy," as Lovejoy put it - and toward the potential for development of a nonmechanististic, nonrationalist theory of scientific knowledge. The result was a new pragmatist epistemology, based on Lovejoy's and Jennings's critiques of the inadequacy of pragmatism's account of scientific knowledge. The first intellectual move, drawing on naturalism and pragmatism, was based on a reinterpretation of science as organized experience. The second, sparked by Henri Bergson's theory of creative evolution, and drawing together elements of Dewey's and James's pragmatisms, produced a new account of the contingency and necessary incompleteness of scientific knowledge. Prompted by the neovitalists' mix of a priori concepts and, in Driesch's case, and adherence to empiricism, Lovejoy's and Jennings's developing pragmatist epistemologies of science explored the interrelation between rationalism and empiricism.

  8. An Image of Britain during the Second World War: The films of Humphrey Jennings (1939-1945 Une image de la Grande-Bretagne pendant la Seconde Guerre mondiale : les films de Humphrey Jennings (1939-1945

    Directory of Open Access Journals (Sweden)

    Elena Von Kassel

    2009-10-01

    Full Text Available Il s’agit de chercher à comprendre comment le style poétique a pu atteindre des sommets avec les films de Humphrey Jennings dans le documentaire anglais et comment ces films résultent d’un mélange entre deux traditions du cinéma britannique, traditions jusque-là opposées. A l’initiative d’Alberto Cavalcanti, en 1939, The First Days, coréalisé par Humphrey Jennings, Harry Watt et Pat Jackson, fut, au tout début la guerre, le premier film offrant une réflexion sur des réalités, lorsque l’on avait essayé de manipuler le public dans Le lion a des ailes, tourné la même année, mais aussi  le premier film anglais de propagande de la Seconde Guerre mondiale, dont Alexander Korda avait lancé et soutenu la réalisation. Quand, partant pour Ealing Studios, Cavalcanti quitte la direction de la GPO Film Unit, il est remplacé par Ian Dalrymple, le producteur du film Le lion a des ailes. C’est sous la direction de Dalrymple qu’au GPO, désormais appelé Crown Film Unit, un nouveau genre de film put émerger. Dans cet esprit démocratique, après The First Days, fut tourné en coréalisation London Can Take It (1940, par Humphrey Jennings et Harry Watt, le thème portant sur la façon dont les Londoniens supportaient les bombardements. Puis, Jennings a réalisé Heart of Britain, le thème portant, cette fois, sur la résistance de toute l’Angleterre. Words for Battle, qui suivit, était un film de propagande historique. Toutefois, c’est avec Listen to Britain, en 1942, que Jennings put vraiment toucher le public. La guerre n’était pas encore gagnée, mais la propagande dans le documentaire anglais était bien plus efficace que celle de l’ennemi, et parvenait, en même temps, à toucher toutes les couches de la population.

  9. Superconducting magnet for a Ku-band maser.

    Science.gov (United States)

    Berwin, R.; Wiebe, E.; Dachel, P.

    1972-01-01

    A superconducting magnet to provide a uniform magnetic field of up to 8000 G in a 1.14-cm gap for the 15.3-GHz (Ku-band) traveling wave maser is described. The magnet operates in a persistent mode in the vacuum environment of a closed-cycle helium refrigerator (4.5 K). The features of a superconducting switch, which has both leads connected to 4.5 K heat stations and thereby does not receive heat generated by the magnet charging leads, are described.

  10. Análise econômica da primeira Lei de Patentes brasileira

    Directory of Open Access Journals (Sweden)

    Andrea Felippe Cabello

    Full Text Available Resumo O Brasil foi um dos primeiros países a ter uma lei de patentes e um dos únicos a conceder prazos de duração da patente de acordo com a qualidade da invenção. Este trabalho analisa um banco de dados inédito com todos os 783 privilégios industriais concedidos sob a vigência da primeira lei de patentes brasileira entre 1830 e 1882. Os resultados mostram que a atividade inventiva esteve conectada à estrutura econômica e social da época e que a escassez de mão de obra incentivou a invenção de máquinas e equipamentos para o setor cafeicultor. O número de patentes apenas começou a se elevar a partir de 1870, quando a economia brasileira passou por grandes mudanças que levaram ao seu desenvolvimento, evidenciando que pouco resultado surge quando se institui uma lei de patentes em um ambiente de estagnação econômica. Mesmo assim, a lei revelou-se o mecanismo menos dispendioso para estimular a atividade inventiva no Brasil do século XIX.

  11. Lei das arqueações de 1684: por uma nova interpretação

    Directory of Open Access Journals (Sweden)

    Salles, Wesley Dartagnan

    2011-01-01

    Full Text Available Neste artigo propõe-se uma nova maneira de interpretar a “lei das arqueações de 1684”. Acredita-se que sua elaboração esteve imbricada numa série de acontecimentos conseguintes ao fim da União-Ibérica, ou seja, mostra-se o processo de sua elaboração. Dessa forma, ao se seguir esse viés, a pesquisa entra em conflito com as interpretações da lei de 1684, cujo foco principal foi ponderar o caráter humanitário do Estado Português, na medida em que a lei procurou proteger os escravos durante o seu transporte marítimo. Ao se propor uma nova forma de abordá-la não se nega que ela surgiu para proteger os escravos, o que se questiona são os porquês do interesse em proteger os negros no tráfico, sobretudo em 1684. Assim, a pesquisa transcende a análise de uma lei sobre o tráfico negreiro e cria ferramentas para se compreender a maneira que o Estado lusitano pensava a escravidão naquele contexto

  12. Airborn Ku-band polarimetric radar remote sensing of terrestrial snow cover

    Science.gov (United States)

    Simon H. Yueh; Steve J. Dinardo; Ahmed Akgiray; Richard West; Donald W. Cline; Kelly Elder

    2009-01-01

    Characteristics of the Ku-band polarimetric scatterometer (POLSCAT) data acquired from five sets of aircraft flights in the winter months of 2006-2008 for the second Cold Land Processes Experiment (CLPX-II) in Colorado are described in this paper. The data showed the response of the Ku-band radar echoes to snowpack changes for various types of background vegetation in...

  13. Klimatizace líhně kuřat

    OpenAIRE

    Petr, Lukáš

    2009-01-01

    Diplomová práce se zabývá návrhem systému klimatizačního zařízení pro prostory s líhněmi kuřat. Práce v úvodu krátce přibližuje problematiku klimatizace, představuje dispozice objektu a nastiňuje požadavky na mikroklima pro správnou inkubaci vajec a líhnutí kuřat. Praktická část diplomové práce se dělí na dva základní úseky, a to výpočtový a návrhový. Výpočtová část se zabývá stanovením množství přiváděného čerstvého klimatizačního vzduchu, výpočtem tepelných ztrát, tepelné zátěže a psychrome...

  14. Princípios matemáticos da filosofia natural: a lei da inércia

    OpenAIRE

    Balola, Raquel

    2011-01-01

    Tese de mestrado, Estudos Clássicos, Universidade de Lisboa, Faculdade de Letras, 2011 O presente trabalho consiste na tradução dos fundamentos dos Philosophiae Naturalis Principia Mathematica de Newton, ou seja, da parte axiomática, e no seu estudo, dando principal relevância ao estudo da Primeira Lei de Newton, ou lei da inércia. Na tentativa de compreender a importância que a Primeira Lei de Newton assume na história da ciência, é impreterível que se recue a Aristóteles, e aos primór...

  15. Ku70, Ku80, and sClusterin: A Cluster of Predicting Factors for Response to Neoadjuvant Chemoradiation Therapy in Patients With Locally Advanced Rectal Cancer

    International Nuclear Information System (INIS)

    Pucci, Sabina; Polidoro, Chiara; Joubert, Alessandro; Mastrangeli, Francesca; Tolu, Barbara; Benassi, Michaela; Fiaschetti, Valeria; Greco, Laura; Miceli, Roberto; Floris, Roberto; Novelli, Giuseppe; Orlandi, Augusto; Santoni, Riccardo

    2017-01-01

    Purpose: The identification of predictive biomarkers for neoadjuvant chemoradiation therapy (CRT) is a current clinical need. The heterodimer Ku70/80 plays a critical role in DNA repair and cell death induction after damage. The aberrant expression and localization of these proteins fail to control DNA repair and apoptosis. sClusterin is the Ku70 partner that sterically inhibits Bax-dependent cell death after damage in some pathologic conditions. This study sought to evaluate the molecular relevance of Ku70-Ku80-Clu as a molecular cluster predicting the response to neoadjuvant CRT in patients with locally advanced rectal cancer (LARC). Methods and Materials: Patients enrolled in this study underwent preoperative CRT followed by surgical excision. A retrospective study based on individual response, evaluated by computed tomography and diffusion-weighted magnetic resonance imaging, identified responder (56%) and no-responder patients (44%). Ku70/80 and Clu expression were observed in biopsy specimens obtained before and after treatment with neoadjuvant CRT from the same LARC patients. In vitro studies before and after irradiation were also performed on radioresistant (SW480) and radiosensitive (SW620) colorectal cancer cell lines, mimicking sensitive or resistant tumor behavior. Results: We found a conventional nuclear localization of Ku70/80 in pretherapeutic tumor biopsies of responder patients, in agreement with their role in DNA repair and regulating apoptosis. By contrast, in the no-responder population we observed an unconventional overexpression of Ku70 in the cytoplasm (P<.001). In this context we also overexpression of sClu in the cytoplasm, which accorded with its role in stabilizing of Bax-Ku70 complex, inhibiting Bax-dependent apoptosis. Strikingly, Ku80 in these tumor tissues was lost (P<.005). In vitro testing of colon cancer cells finally confirmed the results observed in tumor biopsy specimens, proving that Ku70/80-Clu deregulation is extensively

  16. Ku70, Ku80, and sClusterin: A Cluster of Predicting Factors for Response to Neoadjuvant Chemoradiation Therapy in Patients With Locally Advanced Rectal Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Pucci, Sabina, E-mail: sabina.pucci@uniroma2.it; Polidoro, Chiara; Joubert, Alessandro; Mastrangeli, Francesca; Tolu, Barbara; Benassi, Michaela; Fiaschetti, Valeria; Greco, Laura; Miceli, Roberto; Floris, Roberto; Novelli, Giuseppe; Orlandi, Augusto; Santoni, Riccardo

    2017-02-01

    Purpose: The identification of predictive biomarkers for neoadjuvant chemoradiation therapy (CRT) is a current clinical need. The heterodimer Ku70/80 plays a critical role in DNA repair and cell death induction after damage. The aberrant expression and localization of these proteins fail to control DNA repair and apoptosis. sClusterin is the Ku70 partner that sterically inhibits Bax-dependent cell death after damage in some pathologic conditions. This study sought to evaluate the molecular relevance of Ku70-Ku80-Clu as a molecular cluster predicting the response to neoadjuvant CRT in patients with locally advanced rectal cancer (LARC). Methods and Materials: Patients enrolled in this study underwent preoperative CRT followed by surgical excision. A retrospective study based on individual response, evaluated by computed tomography and diffusion-weighted magnetic resonance imaging, identified responder (56%) and no-responder patients (44%). Ku70/80 and Clu expression were observed in biopsy specimens obtained before and after treatment with neoadjuvant CRT from the same LARC patients. In vitro studies before and after irradiation were also performed on radioresistant (SW480) and radiosensitive (SW620) colorectal cancer cell lines, mimicking sensitive or resistant tumor behavior. Results: We found a conventional nuclear localization of Ku70/80 in pretherapeutic tumor biopsies of responder patients, in agreement with their role in DNA repair and regulating apoptosis. By contrast, in the no-responder population we observed an unconventional overexpression of Ku70 in the cytoplasm (P<.001). In this context we also overexpression of sClu in the cytoplasm, which accorded with its role in stabilizing of Bax-Ku70 complex, inhibiting Bax-dependent apoptosis. Strikingly, Ku80 in these tumor tissues was lost (P<.005). In vitro testing of colon cancer cells finally confirmed the results observed in tumor biopsy specimens, proving that Ku70/80-Clu deregulation is extensively

  17. Perhetekijöiden yhteys 8.- ja 9.-luokkalaisten tyttöjen ja poikien itsearvioituun ahdistuneisuuteen -Kouluterveyskysely 2013

    OpenAIRE

    Peltola, Anniina

    2016-01-01

    Suomessa on tutkittu paljon perhetekijöiden ja perhesuhteiden muutosten yhteyksiä lasten hyvinvointiin. Perherakenteiden kuten vuoroasumisen yhteyttä lasten hyvinvointiin on Suomessa tutkittu vähemmän. Tämän tutkimuksen tarkoituksena oli kuvata 8.- ja 9.-luokkalaisten tyttöjen ja poikien perhetekijöitä ja itsearvioitua ahdistuneisuutta sekä niiden välistä yhteyttä. Lisäksi oli tarkoitus tutkia taustatekijöiden yhteyttä itsearvioituun ahdistuneisuuteen. Saatua tietoa voidaan hyödyntää kouluter...

  18. ABB Oy Motors and Generators -yksikön energiansyöttöjen erotus- ja lukitusohjeet

    OpenAIRE

    Chi, Henri

    2017-01-01

    Tämä insinöörityö toteutettiin Quant Finland Oy:lle, joka vastaa Helsingin Pitäjänmäen ABB Motors and Generators -tehtaan kunnossapidosta. Insinöörityön tavoitteena oli luoda energiansyöttöjen lukitus- ja erotusohjeet tehtaan koneistoille, laitteille ja järjestelmille. Tehtaalla on isoja koneita ja laitteita, jonka erotus- ja lukitustoimenpiteitä kaikki eivät osaa. Näin ollen on haluttu mahdollistaa turvallinen työskentely tarjoamalla selkeät erotus- ja lukitusohjeet. ABB Motors and Gene...

  19. Lei civilizadora e inspirada nos princípios da nossa Santa Religião”: Reflexões sobre o uso de símbolos religiosos na Lei de 28 de Setembro de 1871 (Lei do Ventre Livre) – Pará, século XIX

    OpenAIRE

    Freitas Neves, Fernando Arthur; Chaves, Kelly Tavares

    2014-01-01

    O estudo a seguir tem o objetivo de demonstrar os usos dos símbolos religiosos do Catolicismo na lei de emancipação da escravidão nº. 2.040 de 28 de Setembro de 1871, conhecida na historiografia como a Lei do Ventre Livre. Apresentamos as características enfatizadas ou iluminadas sobre esses símbolos religiosos utilizados pelos membros da oligarquia política do Pará, durante o Império, para se propagar ideais de civilização e progresso material para o Estado advindos com a nova Lei; ao mesmo ...

  20. Downregulated Ku70 and ATM associated to poor prognosis in colorectal cancer among Chinese patients

    Directory of Open Access Journals (Sweden)

    Lu YF

    2014-10-01

    Full Text Available Yuanfang Lu,1,2 Jingyan Gao,1,3 Yuanming Lu,1 1Department of Toxicology, School of Public Health, Guilin Medical University, Guangxi, People's Republic of China; 2Department of Clinical Research Center, Affiliated 2nd Hospital of Nanjing Medical University, Nanjing, People's Republic of China; 3Department of Human Anatomy and Histo-Embryology, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China Background: Double-strand DNA breaks (DSBs are a key factor in carcinogenesis. The necessary repair of DSBs is pivotal in maintaining normal cell division. To address the relationship between altered expression of DSB repair of proteins Ku70 and ataxia-telangiectasia mutated (ATM in colorectal cancer (CRC, we examined the expression levels and patterns of Ku70 and ATM in CRC samples. Methods: Expression and coexpression of Ku70 and ATM were investigated by using real-time quantitative polymerase chain reaction assays and confirmed further with fluorescent immunohistochemistry in CRC and pericancerous samples from 112 Chinese patients. Results: Downexpression patterns for both Ku70 and ATM were found in the CRC samples and were significantly associated with advanced tumor node metastasis stage and decreased 5-year overall survival rate. Conclusion: Downregulated Ku70 and ATM were associated with poor disease-free survival. Loss of Ku70 and ATM expression might act as a biomarker to predict poor prognosis in patients with CRC. Keywords: DNA double-strand breaks, ataxia-telangiectasia mutated, Ku70, colorectal cancer

  1. The Ku80 carboxy terminus stimulates joining and artemis-mediated processing of DNA ends.

    Science.gov (United States)

    Weterings, Eric; Verkaik, Nicole S; Keijzers, Guido; Florea, Bogdan I; Wang, Shih-Ya; Ortega, Laura G; Uematsu, Naoya; Chen, David J; van Gent, Dik C

    2009-03-01

    Repair of DNA double-strand breaks (DSBs) is predominantly mediated by nonhomologous end joining (NHEJ) in mammalian cells. NHEJ requires binding of the Ku70-Ku80 heterodimer (Ku70/80) to the DNA ends and subsequent recruitment of the DNA-dependent protein kinase catalytic subunit (DNA-PK(CS)) and the XRCC4/ligase IV complex. Activation of the DNA-PK(CS) serine/threonine kinase requires an interaction with Ku70/80 and is essential for NHEJ-mediated DSB repair. In contrast to previous models, we found that the carboxy terminus of Ku80 is not absolutely required for the recruitment and activation of DNA-PK(CS) at DSBs, although cells that harbored a carboxy-terminal deletion in the Ku80 gene were sensitive to ionizing radiation and showed reduced end-joining capacity. More detailed analysis of this repair defect showed that DNA-PK(CS) autophosphorylation at Thr2647 was diminished, while Ser2056 was phosphorylated to normal levels. This resulted in severely reduced levels of Artemis nuclease activity in vivo and in vitro. We therefore conclude that the Ku80 carboxy terminus is important to support DNA-PK(CS) autophosphorylation at specific sites, which facilitates DNA end processing by the Artemis endonuclease and the subsequent joining reaction.

  2. The Ku80 Carboxy Terminus Stimulates Joining and Artemis-Mediated Processing of DNA Ends▿

    Science.gov (United States)

    Weterings, Eric; Verkaik, Nicole S.; Keijzers, Guido; Florea, Bogdan I.; Wang, Shih-Ya; Ortega, Laura G.; Uematsu, Naoya; Chen, David J.; van Gent, Dik C.

    2009-01-01

    Repair of DNA double-strand breaks (DSBs) is predominantly mediated by nonhomologous end joining (NHEJ) in mammalian cells. NHEJ requires binding of the Ku70-Ku80 heterodimer (Ku70/80) to the DNA ends and subsequent recruitment of the DNA-dependent protein kinase catalytic subunit (DNA-PKCS) and the XRCC4/ligase IV complex. Activation of the DNA-PKCS serine/threonine kinase requires an interaction with Ku70/80 and is essential for NHEJ-mediated DSB repair. In contrast to previous models, we found that the carboxy terminus of Ku80 is not absolutely required for the recruitment and activation of DNA-PKCS at DSBs, although cells that harbored a carboxy-terminal deletion in the Ku80 gene were sensitive to ionizing radiation and showed reduced end-joining capacity. More detailed analysis of this repair defect showed that DNA-PKCS autophosphorylation at Thr2647 was diminished, while Ser2056 was phosphorylated to normal levels. This resulted in severely reduced levels of Artemis nuclease activity in vivo and in vitro. We therefore conclude that the Ku80 carboxy terminus is important to support DNA-PKCS autophosphorylation at specific sites, which facilitates DNA end processing by the Artemis endonuclease and the subsequent joining reaction. PMID:19103741

  3. Initial assessment of an airborne Ku-band polarimetric SAR.

    Energy Technology Data Exchange (ETDEWEB)

    Raynal, Ann Marie; Doerry, Armin Walter

    2013-02-01

    Polarimetric synthetic aperture radar (SAR) has been used for a variety of dual-use research applications since the 1940s. By measuring the direction of the electric field vector from radar echoes, polarimetry may enhance an analysts understanding of scattering effects for both earth monitoring and tactical surveillance missions. Polarimetry may provide insight into surface types, materials, or orientations for natural and man-made targets. Polarimetric measurements may also be used to enhance the contrast between scattering surfaces such as man-made objects and their surroundings. This report represents an initial assessment of the utility of, and applications for, polarimetric SAR at Ku-band for airborne or unmanned aerial systems.

  4. PPO Glastuinbouw en LEI helpen biologische ketenprojecten op weg: "vernieuwing moet wel uit de biologische hoek komen"

    NARCIS (Netherlands)

    Staalduinen, van Jan; Poot, E.H.; Wertheim-Heck, S.C.O.

    2006-01-01

    Het biologische marktsegment is vanwege de hogere kostprijs van het geteelde product een natuurlijke kraamkamer voor productinnovatie. De zoektocht naar tastbaar onderscheid en aansprekende verkoopconcepten vereist multidisciplinaire samenwerking van teelt- en marktonderzoek. LEI en PPO Glastuinbouw

  5. Shuttle orbiter Ku-band radar/communications system design evaluation. Deliverable test equipment evaluation

    Science.gov (United States)

    Maronde, R. G.

    1980-07-01

    The Ku-band test equipment, known as the Deliverable System Test equipment (DSTE), is reviewed and evaluated. The DSTE is semiautomated and computer programs were generated for 14 communication mode tests and 17 radar mode tests. The 31 test modules provide a good cross section of tests with which to exercise the Ku-band system; however, it is very limited when being used to verify Ku-band system performance. More detailed test descriptions are needed, and a major area of concern is the DSTE sell-off procedure which is inadequate.

  6. "Imaging" LEIS of micro-patterned solid oxide fuel cell electrodes

    Science.gov (United States)

    Druce, John; Simrick, Neil; Ishihara, Tatsumi; Kilner, John

    2014-08-01

    Understanding the kinetics of oxygen exchange between the gas phase and a ceramic electrode is key to optimising the performance of electrochemical energy conversion devices such as Solid Oxide Fuel Cells. Clearly the surface chemistry of these materials is important, and surface sensitive techniques such as Low Energy Ion Scattering (LEIS) can provide important compositional information key to unravelling electrode kinetics. In this work, we use high lateral resolution LEIS to perform local analyses of a micropatterned electrode structure, of the type often used for studies of the geometrical dependences of electrode performance. We find that the results are comparable to those for bulk materials, but detect evidence of cation interdiffusion from the electrode to the electrolyte. Finally, we note that this preliminary study could open the prospect of in situ measurements of cells near operating conditions.

  7. “Imaging” LEIS of micro-patterned solid oxide fuel cell electrodes

    Energy Technology Data Exchange (ETDEWEB)

    Druce, John, E-mail: john.druce@i2cner.kyushu-u.ac.jp [International Institute for Carbon Neutral Energy Research (wpi-I2CNER), Kyushu University, Fukuoka 819-0395 (Japan); Simrick, Neil [Department of Materials, Imperial College London, London SW7 2BP (United Kingdom); Ishihara, Tatsumi [International Institute for Carbon Neutral Energy Research (wpi-I2CNER), Kyushu University, Fukuoka 819-0395 (Japan); Kilner, John [International Institute for Carbon Neutral Energy Research (wpi-I2CNER), Kyushu University, Fukuoka 819-0395 (Japan); Department of Materials, Imperial College London, London SW7 2BP (United Kingdom)

    2014-08-01

    Understanding the kinetics of oxygen exchange between the gas phase and a ceramic electrode is key to optimising the performance of electrochemical energy conversion devices such as Solid Oxide Fuel Cells. Clearly the surface chemistry of these materials is important, and surface sensitive techniques such as Low Energy Ion Scattering (LEIS) can provide important compositional information key to unravelling electrode kinetics. In this work, we use high lateral resolution LEIS to perform local analyses of a micropatterned electrode structure, of the type often used for studies of the geometrical dependences of electrode performance. We find that the results are comparable to those for bulk materials, but detect evidence of cation interdiffusion from the electrode to the electrolyte. Finally, we note that this preliminary study could open the prospect of in situ measurements of cells near operating conditions.

  8. Facilitando a compreensão da segunda lei da termodinâmica

    OpenAIRE

    Oliveira, P.M.C. de; Dechoum, K.

    2003-01-01

    A idéia central desse artigo é chamar a atenção para o uso do diagrama T x s na descrição das máquinas térmicas reversíveis. Este diagrama mostra-se extremamente adequado e eficaz no ensino da segunda lei da tertermodinâmica dos processos reversíveis, no entanto uma escolha mostra-se mais apropriada que a outra quando se pretende salientar a universalidade dessa lei e não restringir a análise a uma substância de operação específica com é gás ideal. The central idea of this article is to ca...

  9. Facilitando a compreensão da segunda lei da termodinâmica

    OpenAIRE

    Oliveira,P.M.C. de; Dechoum,K.

    2003-01-01

    A idéia central desse artigo é chamar a atenção para o uso do diagrama T x s na descrição das máquinas térmicas reversíveis. Este diagrama mostra-se extremamente adequado e eficaz no ensino da segunda lei da tertermodinâmica dos processos reversíveis, no entanto uma escolha mostra-se mais apropriada que a outra quando se pretende salientar a universalidade dessa lei e não restringir a análise a uma substância de operação específica com é gás ideal.

  10. Fenomenologia das motivações do adolescente em conflito com a lei

    OpenAIRE

    Jost,Maria Clara

    2010-01-01

    Este trabalho visa a avaliar as motivações mobilizadoras do comportamento do adolescente em conflito com a lei, adotando o conceito interativo do ato infracional. Entrevistas, individuais e semi-estruturadas, foram realizadas com adolescentes do sexo masculino, privados de liberdade. Os conteúdos obtidos foram organizados em núcleos temáticos, analisados fenomenologicamente e articulados às motivações subjacentes. Os resultados revelaram uma ambivalência vivencial que corrompe as subjetividad...

  11. Hypoxia downregulates Ku70/80 expression in cervical carcinoma tumors

    International Nuclear Information System (INIS)

    Lara, Pedro Carlos; Lloret, Marta; Clavo, Bernardino; Apolinario, Rosa Maria; Bordon, Elisa; Rey, Agustin; Falcon, Orlando; Alonso, Ana Ruiz; Belka, Claus

    2008-01-01

    Hypoxia may inhibits the NHEJ DNA repair through downregulating Ku70/80 expression and combined with an increased angiogenesis and altered p53 expression would be responsible for tumor progression in cervical carcinoma

  12. Ku proteins function as corepressors to regulate farnesoid X receptor-mediated gene expression

    International Nuclear Information System (INIS)

    Ohno, Masae; Kunimoto, Masaaki; Nishizuka, Makoto; Osada, Shigehiro; Imagawa, Masayoshi

    2009-01-01

    The farnesoid X receptor (FXR; NR1H4) is a member of the nuclear receptor superfamily and regulates the expression of genes involved in enterohepatic circulation and the metabolism of bile acids. Based on functional analyses, nuclear receptors are divided into regions A-F. To explore the cofactors interacting with FXR, we performed a pull-down assay using GST-fused to the N-terminal A/B region and the C region, which are required for the ligand-independent transactivation and DNA-binding, respectively, of FXR, and nuclear extracts from HeLa cells. We identified DNA-dependent protein kinase catalytic subunit (DNA-PKcs), Ku80, and Ku70 as FXR associated factors. These proteins are known to have an important role in DNA repair, recombination, and transcription. DNA-PKcs mainly interacted with the A/B region of FXR, whereas the Ku proteins interacted with the C region and with the D region (hinge region). Chromatin immunoprecipitation assays revealed that the Ku proteins associated with FXR on the bile salt export pump (BSEP) promoter. Furthermore, we demonstrated that ectopic expression of the Ku proteins decreased the promoter activity and expression of BSEP gene mediated by FXR. These results suggest that the Ku proteins function as corepressors for FXR.

  13. Prometeo I. A program for averaging thermal constants over a Wigner-Wilkins flux spectrum on the Univac UCT of J.E.N

    International Nuclear Information System (INIS)

    Corella, M. R.; Iglesias, T.

    1964-01-01

    The Prometeo I program for the Univac UCT of J.E.N., determines the spectrum of thermal neutrons in equilibrium with a hydrogen-moderated homogeneous mixture from the Wigner-Wilkins differential equation, and averages various, cross sections over the spectrum. The present cross section libraries, available for the Prometeo I , are tabulated. (Author) 4 refs

  14. Researches on detection of barley varieties and lines against Ustilago nuda hordei “Jens.â€? Rostr. Schaffn.in Marmara Region

    OpenAIRE

    Gümüştekin, H.; Akın, K.

    2008-01-01

    This research has been started in 1994 to test barley varieties and lines against Ustilago nuda hordei “Jens.â€? Rostr. Schaffn. In 1994, 14 barley varieties and lines and in 1995 23 barley varieties and lines were tested. After testing 37 varieties and lines, 27 of them were found resistant (R), and 10 of them susceptible (S).

  15. Václav Cílek: Zchudnutí lidstva by bylo jen návratem k normálu [Rozhovor

    Czech Academy of Sciences Publication Activity Database

    Tuček, J.; Cílek, Václav

    2010-01-01

    Roč. 4, 2010.06.25 (2010), s. 1-3 ISSN 1803-4543 Institutional research plan: CEZ:AV0Z30130516 Keywords : mineral resources * oil * oil accidents * global changes Subject RIV: DB - Geology ; Mineralogy http://www.e15.cz/nazory/rozhovory/vaclav-cilek-zchudnuti-lidstva-by-bylo-jen-navratem-k-normalu

  16. Deletion of individual Ku subunits in mice causes an NHEJ-independent phenotype potentially by altering apurinic/apyrimidinic site repair.

    Directory of Open Access Journals (Sweden)

    Yong Jun Choi

    Full Text Available Ku70 and Ku80 form a heterodimer called Ku that forms a holoenzyme with DNA dependent-protein kinase catalytic subunit (DNA-PKCS to repair DNA double strand breaks (DSBs through the nonhomologous end joining (NHEJ pathway. As expected mutating these genes in mice caused a similar DSB repair-defective phenotype. However, ku70(-/- cells and ku80(-/- cells also appeared to have a defect in base excision repair (BER. BER corrects base lesions, apurinic/apyrimidinic (AP sites and single stand breaks (SSBs utilizing a variety of proteins including glycosylases, AP endonuclease 1 (APE1 and DNA Polymerase β (Pol β. In addition, deleting Ku70 was not equivalent to deleting Ku80 in cells and mice. Therefore, we hypothesized that free Ku70 (not bound to Ku80 and/or free Ku80 (not bound to Ku70 possessed activity that influenced BER. To further test this hypothesis we performed two general sets of experiments. The first set showed that deleting either Ku70 or Ku80 caused an NHEJ-independent defect. We found ku80(-/- mice had a shorter life span than dna-pkcs(-/- mice demonstrating a phenotype that was greater than deleting the holoenzyme. We also found Ku70-deletion induced a p53 response that reduced the level of small mutations in the brain suggesting defective BER. We further confirmed that Ku80-deletion impaired BER via a mechanism that was not epistatic to Pol β. The second set of experiments showed that free Ku70 and free Ku80 could influence BER. We observed that deletion of either Ku70 or Ku80, but not both, increased sensitivity of cells to CRT0044876 (CRT, an agent that interferes with APE1. In addition, free Ku70 and free Ku80 bound to AP sites and in the case of Ku70 inhibited APE1 activity. These observations support a novel role for free Ku70 and free Ku80 in altering BER.

  17. RECQ HELICASE RECQL4 PARTICIPATES IN NON-HOMOLOGOUS END JOINING AND INTERACTS WITH THE KU COMPLEX

    DEFF Research Database (Denmark)

    Shamanna, Raghavendra A; Singh, Dharmendra Kumar; Lu, Huiming

    2014-01-01

    -irradiation and resulted in accumulation of 53BP1 foci after irradiation, indicating defects in the processing of DSB. We find that RECQL4 interacts with the Ku70/Ku80 heterodimer, part of the DNA-dependent protein kinase (DNA-PK) complex, via its N-terminal domain. Further, RECQL4 stimulates higher order DNA binding...... of Ku70/Ku80 to a blunt end DNA substrate. Taken together, these results implicate that RECQL4 participates in the NHEJ pathway of DSB repair via a functional interaction with the Ku70/Ku80 complex. This is the first study to provide both in vitro and in vivo evidence for a role of a RecQ helicase...

  18. Analysis of Fade Dynamic at Ku-Band in Malaysia

    Directory of Open Access Journals (Sweden)

    Siat Ling Jong

    2014-01-01

    Full Text Available This work investigates fade dynamics of satellite communication systems in equatorial heavy rain region based on a one year of Ku-band propagation measurement campaign carried out in Universiti Teknologi Malaysia (UTM, Johor, Malaysia. First order statistics of rain attenuation are deduced and the results are found to be in good agreement with those obtained from other beacon measurements gathered within the same area (Kuala Lumpur. Moreover, the fade duration and slope statistics of the satellite signal variations are also carefully derived and subsequently compared with the ITU-R recommendation model. Such information is useful for the system operator and radio communication engineer for the design of appropriate fade mitigation techniques as well as the quality of service that could be offered to the user (according to the time interval for a typical day. Further evaluation on the performances of several ITU-R models in the heavy rain region are needed based on the measurement database available of this climatic region.

  19. Supporting the human life-raft in confronting the juggernaut of technology: Jens Rasmussen, 1961-1986.

    Science.gov (United States)

    Kant, Vivek

    2017-03-01

    Jens Rasmussen's contribution to the field of human factors and ergonomics has had a lasting impact. Six prominent interrelated themes can be extracted from his research between 1961 and 1986. These themes form the basis of an engineering epistemology which is best manifested by his abstraction hierarchy. Further, Rasmussen reformulated technical reliability using systems language to enable a proper human-machine fit. To understand the concept of human-machine fit, he included the operator as a central component in the system to enhance system safety. This change resulted in the application of a qualitative and categorical approach for human-machine interaction design. Finally, Rasmussen's insistence on a working philosophy of systems design as being a joint responsibility of operators and designers provided the basis for averting errors and ensuring safe and correct system functioning. Copyright © 2016 Elsevier Ltd. All rights reserved.

  20. La tradición en la teología de Jenófanes Tradition in Xenophanes's theology

    Directory of Open Access Journals (Sweden)

    Carlos Gustavo Carrasco Meza

    2010-01-01

    Full Text Available Este trabajo busca tanto relacionar la teología de Jenófanes con la cosmovisión heredada de la épica, como encontrar vestigios de la nueva religiosidad griega del siglo VI a. C. La posibilidad de hallar rastros de pitagorismo en los fragmentos nos obliga a postular la relación necesaria entre la defensa de una nueva fe y la crítica a la religión tradicional. Jenófanes atribuye cuatro características a dios: unicidad, inmovilidad, espiritualidad, eternidad. Es posible ver en la obra de Homero una prefiguración de algunos de estos atributos y es posible, además, reconocer en ellos la influencia de las nuevas corrientes mistéricas que reformularon algunos de los conceptos religiosos tradicionales o los rechazaron, dada la incompatibilidad entre la inmoralidad y la divinidad.This article attempts to relate theology of Xenophanes with worldview that goes back to epic poetry and to find traces of new religiosity in century VI B. C. Possibility to find traces of Pythagorism in fragmente forces us to suggest a necessary relation between defense of a new faith and criticism of traditional religión. Xenophanes ascribes to god four characteristics: oneness, immobility, spirituality, eternity. It is possible to find in Homer's work a precedent of some attributes and it is possible too to recognize innuence of new mystery religions that reform many religious concepts or reject them because of incompatibility between immorality and divinity.

  1. Somatic mutation frequency in the stamen hairs of Tradescantia KU 7 and KU 9 clones exposed to low-level gamma rays

    International Nuclear Information System (INIS)

    Ichikawa, S.; Nagashima, C.; Takahashi, C.S.

    1981-01-01

    Two triploid clones (KU 7 and KU 9) of Tradescantia heterozygous for flower color were exposed to 1 to 42.3R of gamma rays or the scattering radiation in the gamma field of the Institute of Radiation . Breeding. Occurrence of somatic pink mutations in the stamen hairs was investigated 10 to 16 (or 14) days after irradiation. The mutation frequency was found to increase linearly with increasing gamma-ray exposure in the both clones, and the frequencies of 0.437 and 0.468 pink mutant events per 10 3 hairs per R were determined for KU 7 and KU 9, respectively. When the data collected in the present study were analyzed together with those obtained in earlier experiments in the gamma field, linear relationships of the somatic mutation frequency with gamma-ray (2.1 to 201.6R) and scattering radiation (0.72 to 57.6R) exposures were confirmed. Scattering radiation was found to have a genetical efficiency more than two times higher than that of gamma rays. Variation of spontaneous mutation frequency observed in the present study and in earlier studies was inversely correlated to temperature variation

  2. A novel small molecule inhibitor of the DNA repair protein Ku70/80.

    Science.gov (United States)

    Weterings, Eric; Gallegos, Alfred C; Dominick, Lauren N; Cooke, Laurence S; Bartels, Trace N; Vagner, Josef; Matsunaga, Terry O; Mahadevan, Daruka

    2016-07-01

    Non-Homologous End-Joining (NHEJ) is the predominant pathway for the repair of DNA double strand breaks (DSBs) in human cells. The NHEJ pathway is frequently upregulated in several solid cancers as a compensatory mechanism for a separate DSB repair defect or for innate genomic instability, making this pathway a powerful target for synthetic lethality approaches. In addition, NHEJ reduces the efficacy of cancer treatment modalities which rely on the introduction of DSBs, like radiation therapy or genotoxic chemotherapy. Consequently, inhibition of the NHEJ pathway can modulate a radiation- or chemo-refractory disease presentation. The Ku70/80 heterodimer protein plays a pivotal role in the NHEJ process. It possesses a ring-shaped structure with high affinity for DSBs and serves as the first responder and central scaffold around which the rest of the repair complex is assembled. Because of this central position, the Ku70/80 dimer is a logical target for the disruption of the entire NHEJ pathway. Surprisingly, specific inhibitors of the Ku70/80 heterodimer are currently not available. We here describe an in silico, pocket-based drug discovery methodology utilizing the crystal structure of the Ku70/80 heterodimer. We identified a novel putative small molecule binding pocket and selected several potential inhibitors by computational screening. Subsequent biological screening resulted in the first identification of a compound with confirmed Ku-inhibitory activity in the low micro-molar range, capable of disrupting the binding of Ku70/80 to DNA substrates and impairing Ku-dependent activation of another NHEJ factor, the DNA-PKCS kinase. Importantly, this compound synergistically sensitized human cell lines to radiation treatment, indicating a clear potential to diminish DSB repair. The chemical scaffold we here describe can be utilized as a lead-generating platform for the design and development of a novel class of anti-cancer agents. Copyright © 2016 Elsevier B.V. All

  3. Radiosensitizing activity and pharmacokinetics of multiple dose administered KU-2285 in peripheral nerve tissue in mice

    International Nuclear Information System (INIS)

    Iwai, Hiroyuki; Matsuno, Etsuko; Sasai, Keisuke; Abe, Mitsuyuki; Shibamoto, Yuta

    1994-01-01

    In a clinical trial in which a 2-nitroimidazole radiosensitizer was administered repeatedly, the dose-limiting toxicity was found to be peripheral neuropathy. In the present study, the in vivo radiosensitizing activity of KU-2285 in combination with radiation dose fractionation, and the pharmacokinetics of cumulative dosing of KU-2285 in the peripheral nerves were examined. The ability of three nitroimidazoles, misonidazole (MISO), etanidazole (SR-2508) and KU-2285, to sensitize SCCVII tumors to radiation treatment has been compared for drug doses in the range 0-200 mg/kg. Single radiation doses or two different fractionation schedules (6 Gy/fractions x three fractions/48 h or 5 Gy/fractions x five fractions/48 h) were used; the tumor cell survival was determined using an in vivo/in vitro colony assay. The pharmacokinetics in the sciatic nerves were undertaken, when KU-2285 or etanidazole were injected at a dose of 200 mg/kg intravenously one, two, three, or four times at 2-h intervals. At less than 100 mg/kg, KU-2285 sensitized SCCVII tumors more than MISO and SR-2508 by fractionated irradiation. Evaluation of pharmacokinetics in the peripheral nerves showed that the apparent biological half-life of SR-2508 increased with the increases in the number of administrations, whereas that of KU-2285 became shorter. Since most clinical radiotherapy is given in small multiple fractions, KU-2285 appears to be a hypoxic cell radiosensitizer that could be useful in such regimens, and that poses no risk of chronic peripheral neurotoxicity. 12 refs., 5 figs., 1 tab

  4. Construction of cell model of silenced Ku80 and the radiobiology change of HeLa cell

    International Nuclear Information System (INIS)

    Zhuang Liang; Yu Shiying; Huang Xiaoyuan; Xiong Huihua; Xiong Hua; Li Xiaolan; Leng Yan

    2007-01-01

    Objective: To construct the cell model of Ku80 with expression inhibited by siRNA and to explore the role of Ku80 in radiobiology. Methods: Ku80-siRNA expression plasmids were constructed and HeLa cells were transfected with these plasmids by lipofectamine. Western blotting was used to measure the expression of Ku80. After irradiation with 6 MV X ray, cells were collected and analyzed by flow cytometry for apoptosis and cell cycle at 24, 48 and 72 h; The radiobiology parameters of four cell lines were acquired by clone formation array. Results: Three stable transfected cell clones were obtained, and the inhibition rates of Ku80 protein expression of two positive clones were 89.3% and 96.4%; The apoptosis rates of HeLa cells Ku80 inhibited were higher than control cells at 48 and 72 after X ray irradiation (P 0.05). HeLa cells of silenced Ku80 had lower SF 2 and D 0 than control cells, and their SER (sensitization enhancement ratio) based on D 10 were 1.315 and 1.365, respectively. Conclusions: The HeLa cell models with Ku80 expression suppressed were successfully established; the inhibition of Ku80 by siRNA could enhance the radiosensitivity of HeLa cells. (authors)

  5. ESPAÇO, MASCULINIDADES E ADOLESCENTES EM CONFLITO COM A LEI

    OpenAIRE

    Silva, Joseli Maria; Rossi, Rodrigo; Chimin Junior, Alides Baptista; Ornat, Marcio Jose

    2012-01-01

    doi: 10.12957/geouerj.2012.3701 Resumo A presente discussão evidencia as formas de relação entre espacialidades e a existência dos adolescentes do sexo masculino em conflito com a lei. O grupo objetivado nesta discussão desenvolve suas masculinidades por meio de vivências concretas que só podem ser compreendidas no tempo e espaço próprios, compostos em grande parte da vulnerabilidade dos adolescentes de baixa renda ao ato infracional, estabelecendo estes práticas cotidianas de relações que es...

  6. Violência contra a mulher e a Lei Maria da Penha

    OpenAIRE

    Ingnácio Duarte, Jozi Rubia; Univesidade Estadual de Londrina (UEL), Londrina; Duarte Pinheiro, Ana Claudia; UEL; Lobo Muniz, Deborah Lídia; UEL; Brun, Simone; UEL

    2009-01-01

    O presente artigo tem como objetivo adentrar no campo jurídico da defesa da mulher brasileira, contra a violência dos mais variados tipos que ela vem sofrendo com o passar dos tempos, analisa a legislação vigente bem como as práticas jurídicas em defesa da mulher e o impacto da lei Maria da Penha. This article aims to enter the field of legal defense of Brazilian women, against violence of all kinds which it has suffered over time, analyzes the current legislation and legal practices in fa...

  7. Expression of Ku70 predicts results of radiotherapy in prostate cancer

    Energy Technology Data Exchange (ETDEWEB)

    Hasegawa, Tomokazu; Someya, Masanori; Hori, Masakazu; Nakata, Kensei; Kitagawa, Mio; Tsuchiya, Takaaki; Sakata, Koh-ichi [Sapporo Medical University School of medicine, Department of Radiology, Chuo-ku, Sapporo, Hokkaido (Japan); Matsumoto, Yoshihisa [Research Laboratory for Nuclear Reactors, Tokyo Institute of Technology, Meguro-ku, Tokyo (Japan); Nojima, Masanori [The University of Tokyo, The Institute of Medical Science Hospital, Minatoku, Tokyo (Japan); Masumori, Naoya [Sapporo Medical University School of medicine, Department of Urology, Chuo-ku, Sapporo, Hokkaido (Japan); Hasegawa, Tadashi [Sapporo Medical University School of medicine, Department of Surgical Pathology, Chuo-ku, Sapporo, Hokkaido (Japan)

    2017-01-15

    Therapeutic strategy for prostate cancer is decided according to T stage, Gleason score, and prostate-specific antigen (PSA) level. These clinical factors are not accurate enough to predict individual risk of local failure of prostate cancer after radiotherapy. Parameters involved with radiosensitivity are required to improve the predictive capability for local relapse. We analyzed 58 patients with localized adenocarcinoma of the prostate between August 2007 and October 2010 treated with 76 Gy of intensity-modulated radiotherapy (IMRT) as a discovery cohort and 42 patients between March 2001 and May 2007 treated with three-dimensional conformal radiotherapy (3D-CRT) as a validation cohort. Immunohistochemical examination for proteins involved in nonhomologous end-joining was performed using biopsy specimens. Ku70 expression was not correlated with various clinical parameters, such as the Gleason score and D'amico risk classification, indicating that Ku70 expression was an independent prognostic factor. The predictive value for PSA relapse was markedly improved after the combination of Gleason score and Ku70 expression, as compared with Gleason score alone. In patients treated with radiotherapy and androgen deprivation therapy (ADT), no relapses were observed in patients with Gleason score ≤7 or low Ku70 expression. In contrast, patients with Gleason score ≥8 and high Ku70 expression had high PSA relapse rates. In the validation cohort, similar results were obtained. Treatment with 76 Gy and ADT can be effective for patients with Gleason score ≤7 or low Ku70 expression, but is not enough for patients with Gleason score ≥8 and high Ku70 expression and, thus, require other treatment approaches. (orig.) [German] Die Behandlung beim Prostatakarzinom ist abhaengig von T-Stadium, Gleason-Score und prostataspezifischem Antigen (PSA). Diese klinischen Faktoren sind jedoch zu ungenau, um das individuelle Lokalrezidivrisiko beim Prostatakarzinom nach

  8. Lei de acesso à informação pública: algumas considerações

    Directory of Open Access Journals (Sweden)

    Sandra Merlo

    2017-04-01

    Full Text Available A Lei de Acesso à Informação visa garantir ao cidadão o acesso às informações na esfera pública brasileira, assim este trabalho objetiva investigar e ter uma compreensão maior em torno da Lei, tendo em vista que a regulamentação é recente e ainda está sendo implementada por órgãos e instituições públicos. A Lei de Acesso à Informação merece um estudo profundo, não só por parte dos Arquivistas, mas também por servidores que trabalham diretamente com a informação pública, para que seja aplicada de forma eficiente e eficaz possibilitando com que o cidadão exerça seus direitos e o Estado cumpra com seus deveres.

  9. O supremo tribunal federal e a lei maria da penha – uma lamentável decisão

    Directory of Open Access Journals (Sweden)

    Rômulo de Andrade Moreira

    2016-09-01

    Full Text Available O trabalho analisa duas decisões tomadas pelo Supremo Tribunal Federal na sessão do último dia 09 de fevereiro. A primeira, por maioria, julgou procedente a ADIn nº. 4424 quanto aos artigos 12, I, 16 e 41 da Lei nº. 11.340/06. Na mesma sessão, por unanimidade, os Ministros acompanharam o voto do relator da ADC nº. 19, Ministro Marco Aurélio, e declararam constitucionais os arts. 1º., 33 e 41 da lei. Discordando do entendimento da Suprema Corte, procuramos confrontar alguns dispositivos da Lei Maria da Penha com a Constituição Federal, concluindo que os seus arts. 17 e 41, além do art. 313, IV do Código de Processo Penal, não devem ser aplicados, pois incompatíveis com a Constituição Federal.

  10. C-terminal low-complexity sequence repeats of Mycobacterium smegmatis Ku modulate DNA binding.

    Science.gov (United States)

    Kushwaha, Ambuj K; Grove, Anne

    2013-01-24

    Ku protein is an integral component of the NHEJ (non-homologous end-joining) pathway of DSB (double-strand break) repair. Both eukaryotic and prokaryotic Ku homologues have been characterized and shown to bind DNA ends. A unique feature of Mycobacterium smegmatis Ku is its basic C-terminal tail that contains several lysine-rich low-complexity PAKKA repeats that are absent from homologues encoded by obligate parasitic mycobacteria. Such PAKKA repeats are also characteristic of mycobacterial Hlp (histone-like protein) for which they have been shown to confer the ability to appose DNA ends. Unexpectedly, removal of the lysine-rich extension enhances DNA-binding affinity, but an interaction between DNA and the PAKKA repeats is indicated by the observation that only full-length Ku forms multiple complexes with a short stem-loop-containing DNA previously designed to accommodate only one Ku dimer. The C-terminal extension promotes DNA end-joining by T4 DNA ligase, suggesting that the PAKKA repeats also contribute to efficient end-joining. We suggest that low-complexity lysine-rich sequences have evolved repeatedly to modulate the function of unrelated DNA-binding proteins.

  11. The Ku heterodimer and the metabolism of single-ended DNA double-strand breaks.

    Science.gov (United States)

    Balestrini, Alessia; Ristic, Dejan; Dionne, Isabelle; Liu, Xiao Z; Wyman, Claire; Wellinger, Raymund J; Petrini, John H J

    2013-06-27

    Single-ended double-strand breaks (DSBs) are a common form of spontaneous DNA break, generated when the replisome encounters a discontinuity in the DNA template. Given their prevalence, understanding the mechanisms governing the fate(s) of single-ended DSBs is important. We describe the influence of the Ku heterodimer and Mre11 nuclease activity on processing of single-ended DSBs. Separation-of-function alleles of yku70 were derived that phenocopy Ku deficiency with respect to single-ended DSBs but remain proficient for NHEJ. The Ku mutants fail to regulate Exo1 activity, and bypass the requirement for Mre11 nuclease activity in the repair of camptothecin-induced single-ended DSBs. Ku mutants exhibited reduced affinity for DNA ends, manifest as both reduced end engagement and enhanced probability of diffusing inward on linear DNA. This study reveals an interplay between Ku and Mre11 in the metabolism of single-ended DSBs that is distinct from repair pathway choice at double-ended DSBs. Copyright © 2013 The Authors. Published by Elsevier Inc. All rights reserved.

  12. The Ku Heterodimer and the Metabolism of Single-Ended DNA Double-Strand Breaks

    Directory of Open Access Journals (Sweden)

    Alessia Balestrini

    2013-06-01

    Full Text Available Single-ended double-strand breaks (DSBs are a common form of spontaneous DNA break, generated when the replisome encounters a discontinuity in the DNA template. Given their prevalence, understanding the mechanisms governing the fate(s of single-ended DSBs is important. We describe the influence of the Ku heterodimer and Mre11 nuclease activity on processing of single-ended DSBs. Separation-of-function alleles of yku70 were derived that phenocopy Ku deficiency with respect to single-ended DSBs but remain proficient for NHEJ. The Ku mutants fail to regulate Exo1 activity, and bypass the requirement for Mre11 nuclease activity in the repair of camptothecin-induced single-ended DSBs. Ku mutants exhibited reduced affinity for DNA ends, manifest as both reduced end engagement and enhanced probability of diffusing inward on linear DNA. This study reveals an interplay between Ku and Mre11 in the metabolism of single-ended DSBs that is distinct from repair pathway choice at double-ended DSBs.

  13. DIFICULDADES PARA IMPLEMENTAÇÃO DA LEI 10.639: A INFLUÊNCIA DOS VALORES RELIGIOSOS SOBRE OS TEMAS APRESENTADOS NO TEXTO DA LEI

    Directory of Open Access Journals (Sweden)

    Glauber Henrique Corrêa Rocha

    2011-09-01

    Full Text Available Normal 0 21 false false false PT-BR X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Tabela normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} Este artigo consiste numa apresentação dos principais resultados obtidos através de entrevistas concedidas por professores de Geografia, no que tange à influência de valores religiosos sobre a aplicação dos conteúdos apresentados pela lei 10.639. A análise que será apresentada busca demonstrar as dificuldades destacadas pelos docentes dessa disciplina no que se refere ao debater sobre o Continente Africano no ambiente escolar. Destacamos este último como sendo o palco onde o currículo praticado é construído e também onde pode ser observada a ação dos valores religiosos – expressos através da prática de professores, alunos e funcionários – que, em alguns casos, apresentam-se como fatores que dificultam o desenvolvimento dos temas apresentados pela lei.    Palavras-Chave: Lei 10.639; ambiente escolar; currículo praticado; valores religiosos.   Abstract   This article is a presentation of the main results obtained through interviews granted by teachers of Geography, regarding the application of content provided by law 10,639. The analysis that will be presented seeks to demonstrate the difficulties highlighted by the teachers of this discipline with regard to the debate on the African continent in the

  14. A FREQUENTE LUTA DAS MULHERES POR PUNIÇÕES AOS SEUS AGRESSORES: FEMINICÍDIO X LEI MARIA DA PENHA

    Directory of Open Access Journals (Sweden)

    Brizza Oliveira Lima

    2017-03-01

    Full Text Available Resumo: Ainda que existam leis no ordenamento jurídico brasileiro que visam proteger os direitos humanos das mulheres, como a lei nº 11.340 de 07 de Agosto de 2006 – Lei Maria da Penha, e a mais recente, lei nº 13.104 de 09 de março de 2015 – Lei do Feminicídio, que inseriu no §2º do artigo 121, do Código Penal a figura do feminicídio como qualificadora do crime de homicídio, perdura ainda, a persistência da violência contra a mulher. Este artigo busca responder a seguinte questão: Se a Lei Maria da Penha fosse mais bem estruturada na sua aplicabilidade, o Feminicídio diminuiria? Com base nas informações coletadas em artigos científicos, pesquisas, leis e em doutrinas do Direito das quais demonstram que a figura do Feminicídio, pode em certas hipóteses imiscuir-se no conhecimento da Lei Maria da Penha, a qual ao ponto de vista deste estudo poderia prevenir diversos feminicídios, preservando a vida de cada uma das mulheres violentadas e muitas vezes mortas.

  15. Teorias da lei natural: Pufendorf e Rousseau Natural law theories: Pufendorf and Rousseau

    Directory of Open Access Journals (Sweden)

    Luiz Felipe Netto de Andrade e Silva Sahd

    2007-01-01

    Full Text Available O presente artigo tem como objetivo reconstruir argumentos centrais desenvolvidos por Jean-Jacques Rousseau. Contra Samuel Pufendorf, Rousseau defende que a justiça não é natural. Ele recusa todo compromisso com a lei natural tradicional para voltar à posição de Thomas Hobbes. Ora, no estado originário de natureza, os princípios racionais da lei natural que expõe Pufendorf não podem ser conhecidos, e, por conseguinte, quando puderem ser conhecidos, não serão aplicados por natureza.The present article aims at reconstructing Jean-Jacques Rousseau’s central arguments. Against Samuel Pufendorf, Rousseau maintains that justice is not natural, thereby rejecting the compromise with traditional natural law and wholly returning to the position of Thomas Hobbes. Now, in the original state of nature, Pufendorf’s rational principles of natural law cannot be known; later, when they may be known, they are not by nature enforced.

  16. Lei 11.645/08: a questão étnico-cultural nas escolas

    Directory of Open Access Journals (Sweden)

    Rosangela Gomes Moreira

    2012-12-01

    Full Text Available Este artigo traz informações sobre o conhecimento que professores e alunos têm da Lei 11.645/2008, que torna obrigatório o ensino das culturas negra e indígena nas Instituições de ensino de todo país. A pesquisa foi desenvolvida com alunos e professores de escolas públicas e privadas do município de Sinop-MT e constatou que o preconceito ainda se faz presente em nossa sociedade, principalmente quando se refere aos negros e aos índios. Verificou-se que a escola é um caminho para a superação dos preconceitos. Dessa forma concluiu-se que o trabalho que está sendo desenvolvido em algumas escolas começa a mostrar resultados positivos na busca da eliminação do preconceito e do racismo, fazendo com que os alunos passem a ver o outro com respeito. Palavras-chave: educação; lei 11.645/2008; professores e alunos.

  17. Low energy ion scattering (LEIS) and the compositional and structural analysis of solid surfaces

    International Nuclear Information System (INIS)

    Berg, J.A. van den; Armour, D.G.

    1981-01-01

    The physics of Low Energy Ion Scattering (LEIS) and its application as a surface analytical technique are reviewed. It is shown that compositional and short-range structural information can be obtained by choosing experimental conditions which optimize the contributions of single and double (or multiple) collisions, respectively. The LEIS technique allows mass analysis in a straightforward way, possesses a high surface selectivity but is unable to provide quantitative information in isolation due to scattering cross-section uncertainties and not easily quantifiable charge exchange effects. Structural information regarding adsorbate positions on single crystal surfaces and the short-range substrate structure (including damaged and reconstructed surfaces) can be obtained by exploiting shadowing and/or multiple scattering phenomena. The progress made in recent years in this area is charted. It is shown that computer simulations often play an important role in this type of study. Effects, such as charge exchange, inelastic energy loss and ion beam surface perturbations, which complicate the use of low energy ion scattering for surface analysis are discussed in detail. The present status of the technique in the different areas of study is indicated. (author)

  18. A Lei Geral de Telecomunicações sob uma perspectiva convergente

    Directory of Open Access Journals (Sweden)

    Renata Tonicelli de M. Quelho

    2011-05-01

    Full Text Available O objetivo do artigo é o de promover a análise da adaptabilidade da Lei Geral de Telecomunicações brasileira, Lei nº 9.472/97 (LGT, a um contexto de convergência. Inicialmente, é trazida uma característica das infraestruturas de tecnologia da informação e comunicação que revela o potencial convergente e a possibilidade de mudança nas estratégias de mercado e nas políticas públicas: a modularidade. Em seguida, são identificados dois cenários limitadores da convergência: a existência de ilhas na política de comunicação e a de silos no regime regulatório. A regulação em camadas é utilizada para análise da convergência. Em face desses elementos, o marco legal de telecomunicações é testado para se demonstrar a relativa adaptabilidade da LGT.

  19. Adolescente em conflito com a lei e medidas socioeducativas: limites e (impossibilidades

    Directory of Open Access Journals (Sweden)

    Francischini, Rosângela

    2005-01-01

    Full Text Available Reinserção social, readaptação, ajustamento social, integração à família e sociedade. Várias são as expressões empregadas para referir-se ao efeito desejado do trabalho com o jovem em conflito com a lei, em cumprimento de medidas socioeducativas, particularmente em privação de liberdade. Parte do aparato legal do Estado, a partir da promulgação do Estatuto da Criança e do Adolescente, significaram, essas medidas, uma chamada à responsabilização do jovens, em face da transgressão cometida. No entanto, avalia-se, o que dá a essas medidas o caráter socioeducativo, fazendo com que o trabalho desenvolvido nas instituições diferencie-se do cumprimento de pena? Estrutura física, formação de recursos humanos, ações educativas e trabalho transdiciplinar são alguns dos aspectos implicados nesta questão. Neste contexto de discussão insere-se o presente artigo, que tem por objetivo discutir o caráter socioeducativo das medidas de privação de liberdade e as possibilidades de reinserção social do jovem em conflito com a lei

  20. LEI DA PALMADA: REFLEXÕES E IMPLICAÇÕES PSICOJURÍDICAS

    Directory of Open Access Journals (Sweden)

    Lohana Pinheiro Feltrin

    2013-07-01

    Full Text Available O objetivo deste trabalho é analisar a interferência do Estado no poder familiar, bem como no que consiste a “Lei da Palmada” e suas consequências na esfera psicológica da criança e do adolescente. Pretende verificar a legislação existente contra os maus-tratos e as mudanças que podem ocorrer com a sanção do referido Projeto de Lei. Como método, utilizou-se o dedutivo e de pesquisa jurisprudencial, no âmbito do Poder Judiciário Gaúcho, a fim de averiguar seu posicionamento nos casos de castigos físicos em menores de idade. Fez-se uma análise interdisciplinar, através de pesquisa bibliográfica, cotejando os aspectos jurídicos com os psicológicos. Concluiu-se que a proposta pouco modificará a condenação por maus-tratos infantis. Não obstante, a palmada com o fito educacional é diferente dos castigos imoderados e, em tese, os pais sabem diferenciá-los. Ressalta-se que os maus-tratos devem ser punidos, mas o Estado não pode interferir na forma como os pais educam os seus filhos.

  1. The Ku70/80 ring in Non-Homologous End-Joining

    DEFF Research Database (Denmark)

    Kragelund, Birthe Brandt; Weterings, Eric; Hartmann-Petersen, Rasmus

    2016-01-01

    /80 heterodimer is a key-player in the NHEJ pathway and binds to DNA termini with high affinity, where it helps to protect DNA ends from degradation and to recruit other NHEJ factors required for repair. The mechanism of Ku70/80 detachment from the DNA helix after completion of DNA repair is incompletely......Non-homologous end-joining (NHEJ) is an essential DNA double strand break repair pathway during all cell cycle stages. Deficiency in NHEJ factors can lead to accumulation of unrepaired DNA breaks or faulty DNA repair, which may ultimately result in cell death, senescence or carcinogenesis. The Ku70...... understood. Some data suggest that certain DNA repair factors are ubiquitylated and targeted for proteasomal degradation after repair. Recent studies suggest that Ku80 is conjugated to lysine48-linked ubiquitin chains by the Skp1-Cullin-F-box (SCF) complex and/or the RING finger protein 8 (RNF8) ubiquitin-protein...

  2. Pohon pásového dopravníku pro transport uhlí

    OpenAIRE

    Kliš, Kamil

    2013-01-01

    Diplomová práce se zabývá návrhem pohonu pásového dopravníku pro transport uhlí. Práce obsahuje nezbytné výpočty dle norem potřebné k určení vhodných komponentů pásového dopravníku. Cílem diplomové práce bylo navrhnout pohon pásového dopravníku, všech jeho potřebných komponentů včetně návrhem rámu pohonu a vytvoření výkresové dokumentace. This diploma thesis deals with designing a drivetrain for a coal belt conveyor. Thesis contains necessary calculations according to norms needed for dete...

  3. Uloga kućnih ljubimaca u socioemocionalnom  razvoju djece školskog uzrasta

    OpenAIRE

    Smojver-Ažić, Sanja; Topalović, Zorica

    2010-01-01

    Rezultati istraživanja potvrđuju kako je odrastanje uz kućnoga ljubimca povezano sa socioemocionalnim razvojem djece. Cilj ovoga istraživanja bio je ispitati odnos u kojemu stoje privrženost majci, privrženost kućnomu ljubimcu i empatija, socijalna kompetencija i usamljenost. U istraživanju je sudjelovalo 480 učenika četvrtoga, šestoga i osmoga razreda osnovnih škola u Istri (226 djevojčica i 254 dječaka) te njihovi roditelji. U ispitanom uzorku 63 % djece ima jednoga ili više kućnih ljubi...

  4. Functional Interplay of the Mre11 Nuclease and Ku in the Response to Replication-Associated DNA Damage ▿

    Science.gov (United States)

    Foster, Steven S.; Balestrini, Alessia; Petrini, John H. J.

    2011-01-01

    The Mre11 complex is a central component of the DNA damage response, with roles in damage sensing, molecular bridging, and end resection. We have previously shown that in Saccharomyces cerevisiae, Ku70 (yKu70) deficiency reduces the ionizing radiation sensitivity of mre11Δ mutants. In this study, we show that yKu70 deficiency suppressed the camptothecin (CPT) and methyl methanesulfonate (MMS) sensitivity of nuclease-deficient mre11-3 and sae2Δ mutants in an Exo1-dependent manner. CPT-induced G2/M arrest, γ-H2AX persistence, and chromosome breaks were elevated in mre11-3 mutants. These outcomes were reduced by yKu70 deficiency. Given that the genotoxic effects of CPT are manifest during DNA replication, these data suggest that Ku limits Exo1-dependent double-strand break (DSB) resection during DNA replication, inhibiting the initial processing steps required for homology-directed repair. We propose that Mre11 nuclease- and Sae2-dependent DNA end processing, which initiates DSB resection prevents Ku from engaging DSBs, thus promoting Exo1-dependent resection. In agreement with this idea, we show that Ku affinity for binding to short single-stranded overhangs is much lower than for blunt DNA ends. Collectively, the data define a nonhomologous end joining (NHEJ)-independent, S-phase-specific function of the Ku heterodimer. PMID:21876003

  5. Interplay between Ku and Replication Protein A in the Restriction of Exo1-mediated DNA Break End Resection*

    Science.gov (United States)

    Krasner, Danielle S.; Daley, James M.; Sung, Patrick; Niu, Hengyao

    2015-01-01

    DNA double-strand breaks can be eliminated via non-homologous end joining or homologous recombination. Non-homologous end joining is initiated by the association of Ku with DNA ends. In contrast, homologous recombination entails nucleolytic resection of the 5′-strands, forming 3′-ssDNA tails that become coated with replication protein A (RPA). Ku restricts end access by the resection nuclease Exo1. It is unclear how partial resection might affect Ku engagement and Exo1 restriction. Here, we addressed these questions in a reconstituted system with yeast proteins. With blunt-ended DNA, Ku protected against Exo1 in a manner that required its DNA end-binding activity. Despite binding poorly to ssDNA, Ku could nonetheless engage a 5′-recessed DNA end with a 40-nucleotide (nt) ssDNA overhang, where it localized to the ssDNA-dsDNA junction and efficiently blocked resection by Exo1. Interestingly, RPA could exclude Ku from a partially resected structure with a 22-nt ssDNA tail and thus restored processing by Exo1. However, at a 40-nt tail, Ku remained stably associated at the ssDNA-dsDNA junction, and RPA simultaneously engaged the ssDNA region. We discuss a model in which the dynamic equilibrium between Ku and RPA binding to a partially resected DNA end influences the timing and efficiency of the resection process. PMID:26067273

  6. Improving DNA double-strand repair inhibitor KU55933 therapeutic index in cancer radiotherapy using nanoparticle drug delivery

    Science.gov (United States)

    Tian, Xi; Lara, Haydee; Wagner, Kyle T.; Saripalli, Srinivas; Hyder, Syed Nabeel; Foote, Michael; Sethi, Manish; Wang, Edina; Caster, Joseph M.; Zhang, Longzhen; Wang, Andrew Z.

    2015-11-01

    Radiotherapy is a key component of cancer treatment. Because of its importance, there has been high interest in developing agents and strategies to further improve the therapeutic index of radiotherapy. DNA double-strand repair inhibitors (DSBRIs) are among the most promising agents to improve radiotherapy. However, their clinical translation has been limited by their potential toxicity to normal tissue. Recent advances in nanomedicine offer an opportunity to overcome this limitation. In this study, we aim to demonstrate the proof of principle by developing and evaluating nanoparticle (NP) formulations of KU55933, a DSBRI. We engineered a NP formulation of KU55933 using nanoprecipitation method with different lipid polymer nanoparticle formulation. NP KU55933 using PLGA formulation has the best loading efficacy as well as prolonged drug release profile. We demonstrated that NP KU55933 is a potent radiosensitizer in vitro using clonogenic assay and is more effective as a radiosensitizer than free KU55933 in vivo using mouse xenograft models of non-small cell lung cancer (NSCLC). Western blots and immunofluorescence showed NP KU55933 exhibited more prolonged inhibition of DNA repair pathway. In addition, NP KU55933 leads to lower skin toxicity than KU55933. Our study supports further investigations using NP to deliver DSBRIs to improve cancer radiotherapy treatment.

  7. John Ellis, Jens Vigen and Mick Storr on handmade knits made for CERN by high-school teachers Inga Hanne Dokka (Kongsberg videregående skole) and Jolanta Nylund (Akademiet Drammen)

    CERN Multimedia

    Pantelia, Anna

    2014-01-01

    Mick Storr wearing a pull-over made by high-school teacher Jolanta Nylund, Akademiet, Drammen. John Ellis and Jens Vigen in jumpers knitted by high-school teacher Inga Hanne Dokka Kongsberg videregående skole.

  8. Experience at JEN with electrochemical cells for measurement of oxygen activity in liquid sodium; Experiencia en la JEN con sondas electroquimicas para medida de la actividad del oxigeno disuelto en sodio liquido

    Energy Technology Data Exchange (ETDEWEB)

    Torre, M de la; Lapena, J; Couchoud, M

    1981-07-01

    This report presents the experience gained at the JEN with Oxygen Meters since 1974 till 1980. Thirteen O.H. were tested. Eight with Cu/Cu{sub 2}O reference electrode and the rest with Sn/SnO{sub 2}, and two types of electrolyte tube produced by Zircon under specifications development by UNC and HEDL. The cells equipped with Cu/Cu{sub 2}O showed an anomalous performance giving an e.m.f. higher than the theoretical value, and one of them was in close agreement cells using air as reference electrode. An explanation is given. The performance of the cells with Sn/SnO{sub 2} is in good agreement with those obtained in others laboratories. To calculate the theoretical value, it has derived a correlation solubility for oxygen with 262 data obtained by the vacuum distillation on method. Various recommendations are pointed out on the future development of the O.H. to improve its performance. (Author) 25 refs.

  9. Prometeo I. A program for averaging thermal constants over a Wigner-Wilkins flux spectrum on the Univac UCT of J.E.N.; Prometo I. Progrma para promediar las constantes termicas con el espectro Wigner-Wikins en la Univac UCT de la J.E.N.

    Energy Technology Data Exchange (ETDEWEB)

    Corella, M R; Iglesias, T

    1964-07-01

    The Prometeo I program for the Univac UCT of J.E.N., determines the spectrum of thermal neutrons in equilibrium with a hydrogen-moderated homogeneous mixture from the Wigner-Wilkins differential equation, and averages various, cross sections over the spectrum. The present cross section libraries, available for the Prometeo I , are tabulated. (Author) 4 refs.

  10. Deletion of individual Ku subunits in mice causes an NHEJ-independent phenotype potentially by altering apurinic/apyrimidinic site repair

    NARCIS (Netherlands)

    Y.J. Choi (Yong Jun); H. Li (Han); M.Y. Son (Mi Young); X.-H. Wang (Xiao-Hong); J.L. Fornsaglio (Jamie L.); R.W. Sobol (Robert W.); M. Lee (Moonsook); J. Vijg (Jan); S. Imholz (Sandra); M.E.T. Dollé (Martijn); H. van Steeg (Harry); E. Reiling (Erwin); P. Hasty (Paul)

    2014-01-01

    textabstractKu70 and Ku80 form a heterodimer called Ku that forms a holoenzyme with DNA dependent-protein kinase catalytic subunit (DNA-PKCS) to repair DNA double strand breaks (DSBs) through the nonhomologous end joining (NHEJ) pathway. As expected mutating these genes in mice caused a similar DSB

  11. Analysis of metals in asphaltenes of KU-46 by PIXE analysis; Analisis de metales en asfaltenos de crudo mexicano KU-46 por PIXE

    Energy Technology Data Exchange (ETDEWEB)

    Navidad G, P.; Pina L, L.I.; Lopez M, J.; Ramirez T, J.J.; Aspiazu F, J.A.; Romero G, E.T. [Gerencia de Ciencias Basicas, Instituto Nacional de Investigaciones Nucleares, A.P. 18-1027, 11801 Mexico D.F. (Mexico)

    2002-07-01

    The content of metals of the asphaltenes obtained from the KU-46 mexican crude with n-heptane was evaluated. The found metals in higher concentration are transition metals as well as the vanadium, nickel, copper and zinc. Moreover the sulfur in high concentrations was quantified. The metallic content of the asphaltenes revealed that the crude contains a lower quantity of metals unlike the vacuum residue previously analysed. (Author)

  12. CRIMES EM ESPÉCIE NA LEI Nº 11.101/2005: UMA ANÁLISE CRÍTICA

    Directory of Open Access Journals (Sweden)

    Helena Beatriz de Moura Belle

    2015-12-01

    Full Text Available No presente artigo tem-se por objetivo apresentar e analisar os tipos penais dispostos na Lei nº 11.101, de 9 de fevereiro de 2005, que regula a recuperação judicial e extrajudicial e a falência do empresário e da sociedade empresária. A metodologia de pesquisa adotada foi a qualitativa e procedimentos metodológicos por análise documental, mediante utilização de fontes bibliográficas e ordenamento jurídico brasileiro vigente. Verificou-se que não há convergências entre os doutrinadores a respeito da tipificação determinada na referida lei e que, indubitavelmente, todos os ilícitos ali especificados também são qualificados no Código Penal brasileiro, Decreto-Lei nº 2.848/1940, com diferenças no que se refere ao tempo de cumprimento de penas, causas atenuantes e agravantes. Assim, compreende-se que os dispositivos penais contidos na lei especial servem muito mais para identificar e qualificar os ilícitos cometidos nas fases dos dois institutos analisados, recuperação e falência de devedor insolvente.

  13. MIGRATION OF CU ADATOMS ON A CU(100) SURFACE, STUDIED WITH LOW-ENERGY ION-SCATTERING (LEIS)

    NARCIS (Netherlands)

    BREEMAN, M; BOERMA, DO

    1992-01-01

    We report the observation of adatoms appearing on the surface due to ion beam irradiation. These adatoms are interpreted to be self-interstitials, created in the damage cascades, which have diffused to the surface where they are trapped. From our LEIS experiments on a stepped Cu(100) surface we

  14. Aderência dos municípios cearenses à lei da transparência

    OpenAIRE

    Júlio César Muniz Filho; Renata Bessa Pontes

    2014-01-01

    A transparência pública decorre diretamente do princípio da publicidade e é uma ferramenta de controle dos ingressos e dispêndios públicos. Para controlar sua eficácia, surge a Lei Complementar nº 131/2009, que alterou a redação da LRF no que se refere à transparência da gestão fiscal. A fim de facilitar o acesso às informações relativas à gestão pública, o instrumento utilizado são os portais de transparência. Esta pesquisa objetivou analisar a aderência dos municípios cearenses às exigência...

  15. Santos, Ana Cristina, A Lei do Desejo. Direitos Humanos e Minorias Sexuais em Portugal

    Directory of Open Access Journals (Sweden)

    Madalena Duarte

    2012-10-01

    Full Text Available A Lei do Desejo, de autoria de Ana Cristina Santos, é um texto sobre os impactos da utilização do regime europeu de direitos humanos por parte do movimento lésbico, gay, bissexual e transgénero (LGBT português. Surge com base na tese apresentada pela autora no âmbito do Mestrado em Sociologia pela Faculdade de Economia da Universidade de Coimbra, em 2003. O título, além de ser uma sugestiva alusão à obra de Almodôvar, é já bem indiciador da proposta desta obra. Basta que, para tal, entendamo...

  16. LEI, MORAL E OPRESSÃO DOS GRUPOS CIGANOS NOS OITOCENTOS

    Directory of Open Access Journals (Sweden)

    Camila Similhana Oliveira Sousa

    2013-10-01

    Full Text Available RESUMO:Estudo dos relatórios da Chefia de Polícia disponíveis no Arquivo Público Mineiro no que se refere à repressão dos grupos ciganos entre 1890 e 1908, nos primeiros anos da república brasileira, contexto esse em que as elites republicanas buscavam a modernização econômica e urbana, sem dedicar-se à inserção das camadas menos favorecidas. PALAVRAS-CHAVE: Ciganos – Lei – Repressão ABSTRACT: Study reports of the Chief of Police on the Public Archives Miner regarding the repression of Roma groups between 1890 and 1908, in this context that the republican elites sought economic modernization and urban, without devoting themselves to the insertion of the less affluent. KEYWORDS: Gypsies. Law Repression.Recebido: 14/08/2013    Aceito: 20/08/2013

  17. Atendimento à Lei Arouca no Ensino de Farmacologia no Curso de Medicina, UFC, Sobral

    Directory of Open Access Journals (Sweden)

    Thiago de Vasconcelos Saraiva

    Full Text Available RESUMO De acordo com a Lei Arouca (Lei n° 11.794 – 2008, que estabelece critérios para “a criação e a utilização de animais em atividades de ensino e pesquisa científica, em todo o território nacional”, tem-se que, “sempre que possível, as práticas de ensino deverão ser fotografadas, filmadas ou gravadas, de forma a permitir sua reprodução para ilustração de práticas futuras, evitando-se a repetição desnecessária de procedimentos didáticos com animais”. O objetivo deste estudo foi relatar o desenvolvimento de um software (Pharmasoftware® como método alternativo de ensino em Farmacologia no curso de Medicina da Universidade Federal do Ceará (UFC, Campus Sobral. Para a certificação, foram utilizados dois grupos de alunos, um em aula prática convencional e outro com o Pharmasoftware®. A análise dos resultados revelou que ambas as atividades foram igualmente eficazes em auxiliar na consolidação do tema Vias de Administração dos Fármacos, evidenciando, assim, o Pharmasoftware® como uma ferramenta capaz de auxiliar no ensino da Farmacologia e, ainda, de fomentar a implantação de outros métodos alternativos de ensino de Farmacologia nas Instituições de Ensino Superior.

  18. Sistema Salicweb: democratização no acesso à lei Rouanet?

    Directory of Open Access Journals (Sweden)

    Thabatta Pamela Toscan dos Santos

    2016-12-01

    Full Text Available Este artigo contribui com pesquisas na interface da comunicação, da democracia e dos serviços públicos, na medida em que analisa o real benefício da implantação da plataforma digital SALICWEB no Ministério da Cultura, especificamente em relação aos pedidos de incentivo fiscal da Lei Rouanet. Para tanto, o texto se utiliza dos seguintes teóricos: Max Weber, que analisa os processos de dominação e autoridade; Edson de Oliveira Nunes, que aborda o clientelismo na burocracia; e Moreira e Maia, que questiona se as tecnologias geram independência ou dependência nos usuários. Como conclusão, este artigo defende que a implantação do sistema SALICWEB pelo Ministério da Cultura foi benéfica e importante, principalmente por minimizar a demora burocrática da Lei Rouanet. Por outro lado, defende-se que o formato de envio de propostas por correspondência não deveria ser extinto, pois atualmente há uma dependência do proponente em relação à tecnologia, que já apresentou e ainda apresenta falhas e problemas técnicos.DOI: http://dx.doi.org/10.21882/ruc.v4i7.645 Recebido: 15/07/2016 Publicado: 07/12/2016 

  19. Kuřim–the largest small town in the South-Moravian Region (Czechia)

    Czech Academy of Sciences Publication Activity Database

    Vaishar, Antonín

    2015-01-01

    Roč. 8, č. 8 (2015), s. 135-147 ISSN 2084-5456 Institutional support: RVO:68145535 Keywords : small town * suburbanization * Kuřim Subject RIV: DE - Earth Magnetism, Geodesy, Geography http://annalesgeo.up.krakow.pl/article/view/2839/2502

  20. A Ku-band magnetically insulated transmission line oscillator with overmoded slow-wave-structure

    Science.gov (United States)

    Jiang, Tao; He, Jun-Tao; Zhang, Jian-De; Li, Zhi-Qiang; Ling, Jun-Pu

    2016-12-01

    In order to enhance the power capacity, an improved Ku-band magnetically insulated transmission line oscillator (MILO) with overmoded slow-wave-structure (SWS) is proposed and investigated numerically and experimentally. The analysis of the dispersion relationship and the resonant curve of the cold test indicate that the device can operate at the near π mode of the TM01 mode, which is useful for mode selection and control. In the particle simulation, the improved Ku-band MILO generates a microwave with a power of 1.5 GW and a frequency of 12.3 GHz under an input voltage of 480 kV and input current of 42 kA. Finally, experimental investigation of the improved Ku-band MILO is carried out. A high-power microwave (HPM) with an average power of 800 MW, a frequency of 12.35 GHz, and pulse width of 35 ns is generated under a diode voltage of 500 kV and beam current of 43 kA. The consistency between the experimental and simulated far-field radiation pattern confirms that the operating mode of the improved Ku-band MILO is well controlled in π mode of the TM01 mode. Project supported partly by the National Natural Science Foundation of China (Grant No. 61171021).

  1. Development of intense terahertz coherent synchrotron radiation at KU-FEL

    Energy Technology Data Exchange (ETDEWEB)

    Sei, Norihiro, E-mail: sei.n@aist.go.jp [Research Institute for Measurement and Analytical Instrumentation, National Institute of Advanced Industrial Science and Technology, 1-1-1 Umezono, Umezono, Tsukuba, Ibaraki 305-8568 (Japan); Zen, Heishun; Ohgaki, Hideaki [Institute for Advanced Energy, Kyoto University, Gokasho, Uji, Kyoto 611-0011 (Japan)

    2016-10-01

    We produced intense coherent synchrotron radiation (CSR) in the terahertz (THz) region using an S-band linac at the Kyoto University Free Electron Laser (KU-FEL), which is a mid-infrared free-electron laser facility. The CSR beam was emitted from short-pulse electron bunches compressed by a 180° arc, and was transferred to air at a large solid angle of 0.10 rad. The measured CSR energy was 55 μJ per 7 μs macropulse, and KU-FEL was one of the most powerful CSR sources in normal conducting linear accelerator facilities. The CSR spectra were measured using an uncooled pyroelectric detector and a Michelson-type interferometer designed specifically for the KU-FEL electron beam, and had a maximum at a frequency of 0.11 THz. We found that adjusting the energy slit enhanced the CSR energy and shortened the electron beam bunch length in the CSR spectra measurements. Our results demonstrated that the efficient use of the energy slit can help improve the characteristics of CSR. - Highlights: • We have developed intense coherent synchrotron radiation (CSR) at KU-FEL. • The elevation angle of the CSR was correctly measured by a new technique. • The CSR power extracted to the air was 55 μJ per 7 μs macropulse. • It was demonstrated that an energy slit was effective to improve the CSR properties.

  2. An integrated Ka/Ku-band payload for personal, mobile and private business communications

    Science.gov (United States)

    Hayes, Edward J.; Keelty, J. Malcolm

    1991-01-01

    The Canadian Department of Communications has been studying options for a government-sponsored demonstration payload to be launched before the end of the century. A summary of the proposed system concepts and network architectures for providing an advanced private business network service at Ku-band and personal and mobile communications at Ka-band is presented. The system aspects addressed include coverage patterns, traffic capacity, and grade of service, multiple access options as well as special problems, such as Doppler in mobile applications. Earth terminal types and the advanced payload concept proposed in a feasibility study for the demonstration mission are described. This concept is a combined Ka-band/Ku-band payload which incorporates a number of advanced satellite technologies including a group demodulator to convert single-channel-per-carrier frequency division multiple access uplink signals to a time division multiplex downlink, on-board signal regeneration, and baseband switching to support packet switched data operation. The on-board processing capability of the payload provides a hubless VSAT architecture which permits single-hop full mesh interconnectivity. The Ka-band and Ku-band portions of the payload are fully integrated through an on-board switch, thereby providing the capability for fully integrated services, such as using the Ku-band VSAT terminals as gateway stations for the Ka-band personal and mobile communications services.

  3. Development of intense terahertz coherent synchrotron radiation at KU-FEL

    International Nuclear Information System (INIS)

    Sei, Norihiro; Zen, Heishun; Ohgaki, Hideaki

    2016-01-01

    We produced intense coherent synchrotron radiation (CSR) in the terahertz (THz) region using an S-band linac at the Kyoto University Free Electron Laser (KU-FEL), which is a mid-infrared free-electron laser facility. The CSR beam was emitted from short-pulse electron bunches compressed by a 180° arc, and was transferred to air at a large solid angle of 0.10 rad. The measured CSR energy was 55 μJ per 7 μs macropulse, and KU-FEL was one of the most powerful CSR sources in normal conducting linear accelerator facilities. The CSR spectra were measured using an uncooled pyroelectric detector and a Michelson-type interferometer designed specifically for the KU-FEL electron beam, and had a maximum at a frequency of 0.11 THz. We found that adjusting the energy slit enhanced the CSR energy and shortened the electron beam bunch length in the CSR spectra measurements. Our results demonstrated that the efficient use of the energy slit can help improve the characteristics of CSR. - Highlights: • We have developed intense coherent synchrotron radiation (CSR) at KU-FEL. • The elevation angle of the CSR was correctly measured by a new technique. • The CSR power extracted to the air was 55 μJ per 7 μs macropulse. • It was demonstrated that an energy slit was effective to improve the CSR properties.

  4. Synthetic lethality between murine DNA repair factors XLF and DNA-PKcs is rescued by inactivation of Ku70

    DEFF Research Database (Denmark)

    Xing, Mengtan; Bjørås, Magnar; Daniel, Jeremy A

    2017-01-01

    DNA double-strand breaks (DSBs) are recognized and repaired by the Classical Non-Homologous End-Joining (C-NHEJ) and Homologous Recombination pathways. C-NHEJ includes the core Ku70 and Ku80 (or Ku86) heterodimer that binds DSBs and thus promotes recruitment of accessory downstream NHEJ factors XLF......, PAXX, DNA-PKcs, Artemis and other core subunits, XRCC4 and DNA Ligase 4 (Lig4). In the absence of core C-NHEJ factors, DNA repair can be performed by Alternative End-Joining, which likely depends on DNA Ligase 1 and DNA Ligase 3. Genetic inactivation of C-NHEJ factors, such as Ku70, Ku80, XLF, PAXX...... with severe apoptosis in the central nervous system. Here, we demonstrate that inactivation of the Ku70 gene rescues the synthetic lethality between XLF and DNA-PKcs, resulting in triple knockout mice that are indistinguishable from Ku70-deficient littermates by size or levels of genomic instability. Moreover...

  5. Loss of MLH1 sensitizes colon cancer cells to DNA-PKcs inhibitor KU60648.

    Science.gov (United States)

    Hinrichsen, Inga; Ackermann, Anne; Düding, Tonja; Graband, Annika; Filmann, Natalie; Plotz, Guido; Zeuzem, Stefan; Brieger, Angela

    2017-07-01

    Germline mutations of MLH1 are responsible for tumor generation in nearly 50% of patients with Lynch Syndrome, and around 15% of sporadic colorectal cancers show MLH1-deficiency due to promotor hypermethylation. Although these tumors are of lower aggressiveness the benefit for these patients from standard chemotherapy is still under discussion. Recently, it was shown that the sensitivity to the DNA-PKcs inhibitor KU60648 is linked to loss of the MMR protein MSH3. However, loss of MSH3 is rather secondary, as a consequence of MMR-deficiency, and frequently detectable in MLH1-deficient tumors. Therefore, we examined the expression of MLH1, MSH2, MSH6, and MSH3 in different MMR-deficient and proficient cell lines and determined their sensitivity to KU60648 by analyzing cell viability and survival. MLH1-dependent ability of double strand break (DSB) repair was monitored after irradiation via γH2AX detection. A panel of 12 colon cancer cell lines, two pairs of cells, where MLH1 knock down was compared to controls with the same genetic background, and one MLH1-deficient cell line where MLH1 was overexpressed, were included. In summary, we found that MLH1 and/or MSH3-deficient cells exhibited a significantly higher sensitivity to KU60648 than MMR-proficient cells and that overexpression of MLH1 in MLH1-deficient cells resulted in a decrease of cell sensitivity. KU60648 efficiency seems to be associated with reduced DSB repair capacity. Since the molecular testing of colon tumors for MLH1 expression is a clinical standard we believe that MLH1 is a much better marker and a greater number of patients would benefit from KU60648 treatment. © 2017 Wiley Periodicals, Inc.

  6. DNA-PK/Ku complex binds to latency-associated nuclear antigen and negatively regulates Kaposi's sarcoma-associated herpesvirus latent replication

    Energy Technology Data Exchange (ETDEWEB)

    Cha, Seho [Department of Life Science, Dongguk Univ-Seoul, Seoul 100-715 (Korea, Republic of); Lim, Chunghun [Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305-701 (Korea, Republic of); Lee, Jae Young [Department of Life Science, Dongguk Univ-Seoul, Seoul 100-715 (Korea, Republic of); Song, Yoon-Jae [Department of Life Science, Kyungwon University, Seongnam-Si, Kyeonggi-Do 461-701 (Korea, Republic of); Park, Junsoo [Division of Biological Science and Technology, Yonsei University, Wonju 220-100 (Korea, Republic of); Choe, Joonho [Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305-701 (Korea, Republic of); Seo, Taegun, E-mail: tseo@dongguk.edu [Department of Life Science, Dongguk Univ-Seoul, Seoul 100-715 (Korea, Republic of)

    2010-04-16

    During latent infection, latency-associated nuclear antigen (LANA) of Kaposi's sarcoma-associated herpesvirus (KSHV) plays important roles in episomal persistence and replication. Several host factors are associated with KSHV latent replication. Here, we show that the catalytic subunit of DNA protein kinase (DNA-PKcs), Ku70, and Ku86 bind the N-terminal region of LANA. LANA was phosphorylated by DNA-PK and overexpression of Ku70, but not Ku86, impaired transient replication. The efficiency of transient replication was significantly increased in the HCT116 (Ku86 +/-) cell line, compared to the HCT116 (Ku86 +/+) cell line, suggesting that the DNA-PK/Ku complex negatively regulates KSHV latent replication.

  7. DNA-PK/Ku complex binds to latency-associated nuclear antigen and negatively regulates Kaposi's sarcoma-associated herpesvirus latent replication

    International Nuclear Information System (INIS)

    Cha, Seho; Lim, Chunghun; Lee, Jae Young; Song, Yoon-Jae; Park, Junsoo; Choe, Joonho; Seo, Taegun

    2010-01-01

    During latent infection, latency-associated nuclear antigen (LANA) of Kaposi's sarcoma-associated herpesvirus (KSHV) plays important roles in episomal persistence and replication. Several host factors are associated with KSHV latent replication. Here, we show that the catalytic subunit of DNA protein kinase (DNA-PKcs), Ku70, and Ku86 bind the N-terminal region of LANA. LANA was phosphorylated by DNA-PK and overexpression of Ku70, but not Ku86, impaired transient replication. The efficiency of transient replication was significantly increased in the HCT116 (Ku86 +/-) cell line, compared to the HCT116 (Ku86 +/+) cell line, suggesting that the DNA-PK/Ku complex negatively regulates KSHV latent replication.

  8. Volba idolů ve školním věku (Pop-Pantheon)

    OpenAIRE

    Ryba, Zdeněk

    2016-01-01

    Title: Idolization In The School Age (Pop-Pantheon) Author: Zdeněk Ryba Department: Department of Psychology Supervizor: doc. PhDr. Miloš Kučera, CSc. The main theme of this thesis is basic-school-age children choice of idols. The work is a part of Miloš Kučera research at Faculty of Education UK and it follows up the Mikšíček (1999) and Kravcová (2008) conclusions in their diploma thesis and short Kučera's contribution. The goal of this thesis is to make a database of idols and to create mod...

  9. Ku70 is required for late B cell development and immunoglobulin heavy chain class switching.

    Science.gov (United States)

    Manis, J P; Gu, Y; Lansford, R; Sonoda, E; Ferrini, R; Davidson, L; Rajewsky, K; Alt, F W

    1998-06-15

    Immunoglobulin (Ig) heavy chain (HC) class switch recombination (CSR) is a late B cell process that involves intrachromosomal DNA rearrangement. Ku70 and Ku80 form a DNA end-binding complex required for DNA double strand break repair and V(D)J recombination. Ku70(-/-) (K70T) mice, like recombination activating gene (RAG)-1- or RAG-2-deficient (R1T or R2T) mice, have impaired B and T cell development at an early progenitor stage, which is thought to result at least in part from defective V(D)J recombination (Gu, Y., K.J. Seidl, G.A. Rathbun, C. Zhu, J.P. Manis, N. van der Stoep, L. Davidson, H.L. Cheng, J.M. Sekiguchi, K. Frank, et al. 1997. Immunity. 7:653-665; Ouyang, H., A. Nussenzweig, A. Kurimasa, V.C. Soares, X. Li, C. Cordon-Cardo, W. Li, N. Cheong, M. Nussenzweig, G. Iliakis, et al. 1997. J. Exp. Med. 186:921-929). Therefore, to examine the potential role of Ku70 in CSR, we generated K70T mice that carry a germline Ig HC locus in which the JH region was replaced with a functionally rearranged VH(D)JH and Ig lambda light chain transgene (referred to as K70T/HL mice). Previously, we have shown that B cells from R1T or R2T mice carrying these rearranged Ig genes (R1T/HL or R2T/HL mice) can undergo CSR to IgG isotypes (Lansford, R., J. Manis, E. Sonoda, K. Rajewsky, and F. Alt. 1998. Int. Immunol. 10:325-332). K70T/HL mice had significant numbers of peripheral surface IgM+ B cells, which generated serum IgM levels similar to those of R2T/HL mice. However, in contrast to R2T/HL mice, K70T/HL mice had no detectable serum IgG isotypes. In vitro culture of K70T/HL B cells with agents that induce CSR in normal or R2T/HL B cells did lead to the induction of germline CH transcripts, indicating that initial signaling pathways for CSR were intact in K70T/HL cells. However, treatment with such agents did not lead to detectable CSR by K70T/HL B cells, and instead, led to cell death within 72 h. We conclude that Ku70 is required for the generation of B cells that have

  10. EXPLORAÇÃO DO CONCEITO DE VIOLÊNCIA PSICOLÓGICA NA LEI 11.340/06

    OpenAIRE

    Vier Machado, Isadora; Dezanoski, Mayara

    2014-01-01

    A cultura de submissão das mulheres em relação aos homens, continua presente na atual sociedade e favorece, em grande medida, os índices do fenômeno de violência doméstica. Desta forma, diante da insuficiência protetiva às mulheres, houve a necessidade da criação da Lei 11.340/06, também conhecida como Lei Maria da Penha, que instituiu as diversas formas de violências a serem prevenidas ou enfrentadas; dentre elas, a violência psicológica, sem, contudo, criminalizá-las, ao passo que, como ser...

  11. A PELE (LEI DA ESCRITURA: DURAS E O QUE PERDURA DE PERDA PURA

    Directory of Open Access Journals (Sweden)

    Arminda Silva de Serpa

    2014-02-01

    Full Text Available A relação entre lei e escritura é o tema central desse trabalho. Destacamos, como textos básicos, A Doença da Morte, de Duras e Televisão, de Lacan. A expressão lacaniana: "do que perdura de perda pura ao que só aposta do pai ao pior" serviu-nos como fundamento para pensar a "dura lex" da dissolução, que também poderia ser chamada de "perda pura" ou ainda o "toque do real". Duras escreve sobre a ausência, a vivência trágica do abandono; o lugar do erótico como fenda, intermitência; a festa da língua e o "jogo da mão quente", ou seja, sobre "babel feliz". Esta teia das confusões da língua, do entrelaçamento de línguas foi denominada por Barthes como texto do prazer e prazer do texto, isto é, a escritura como pura fruição. Esta é analisada aqui através do que Brandão denominou de narrativa-espelho, apreendida como metáfora do reflexo, refluxo e do corte, relacionada ao simbólico, imaginário e ao conceito de real. O literário, desta forma, é visto como território da miragem, da "língua secreta" do sexo e da castração; da "inversão nos lábios" e "ouvidos" ou "lituraterra", letra e lixo. Terra. Nesta outra versão do que está dentro, mas fora; do que está fora, mas dentro – Lacan aponta o nó da escritura de Duras como um belo envoltório. Nele, o centro está no perigo do olhar, da angústia. Nosso estudo, portanto, é uma leitura de Duras, atravessada por outra de Lacan sobre Duras, como uma técnica en Abyme. A prática da letra em Duras é reveladora, segundo Lacan, de uma escrita do inconsciente pois expõe a convergência entre a demanda da letra, do desejo e a angústia da lei da "perda pura". Do almar.

  12. Restoration of X-ray resistance and V(D)J recombination in mutant cells by Ku cDNA

    International Nuclear Information System (INIS)

    Smider, V.; Rathmell, W.K.; Chu, G.; Lieber, M.R.

    1994-01-01

    Three genetic complementation groups of rodent cells are defective for both repair of x-ray-induced double-strand breaks and V(D)J recombination. Cells from one group lack a DNA end-binding activity that is biochemically and antigenically similar to the Ku autoantigen. Transfection of complementary DNA (cDNA) that encoded the 86-kilodalton subunit of Ku rescued these mutant cells for DNA end-binding activity, x-ray resistance, and V(D)J recombination activity. These results establish a role for Ku in DNA repair and recombination. Furthermore, as a component of a DNA-dependent protein kinase, Ku may initiate a signaling pathway induced by DNA damage

  13. Ku-mediated coupling of DNA cleavage and repair during programmed genome rearrangements in the ciliate Paramecium tetraurelia.

    Directory of Open Access Journals (Sweden)

    Antoine Marmignon

    2014-08-01

    Full Text Available During somatic differentiation, physiological DNA double-strand breaks (DSB can drive programmed genome rearrangements (PGR, during which DSB repair pathways are mobilized to safeguard genome integrity. Because of their unique nuclear dimorphism, ciliates are powerful unicellular eukaryotic models to study the mechanisms involved in PGR. At each sexual cycle, the germline nucleus is transmitted to the progeny, but the somatic nucleus, essential for gene expression, is destroyed and a new somatic nucleus differentiates from a copy of the germline nucleus. In Paramecium tetraurelia, the development of the somatic nucleus involves massive PGR, including the precise elimination of at least 45,000 germline sequences (Internal Eliminated Sequences, IES. IES excision proceeds through a cut-and-close mechanism: a domesticated transposase, PiggyMac, is essential for DNA cleavage, and DSB repair at excision sites involves the Ligase IV, a specific component of the non-homologous end-joining (NHEJ pathway. At the genome-wide level, a huge number of programmed DSBs must be repaired during this process to allow the assembly of functional somatic chromosomes. To understand how DNA cleavage and DSB repair are coordinated during PGR, we have focused on Ku, the earliest actor of NHEJ-mediated repair. Two Ku70 and three Ku80 paralogs are encoded in the genome of P. tetraurelia: Ku70a and Ku80c are produced during sexual processes and localize specifically in the developing new somatic nucleus. Using RNA interference, we show that the development-specific Ku70/Ku80c heterodimer is essential for the recovery of a functional somatic nucleus. Strikingly, at the molecular level, PiggyMac-dependent DNA cleavage is abolished at IES boundaries in cells depleted for Ku80c, resulting in IES retention in the somatic genome. PiggyMac and Ku70a/Ku80c co-purify as a complex when overproduced in a heterologous system. We conclude that Ku has been integrated in the Paramecium

  14. Xrcc1-dependent and Ku-dependent DNA double-strand break repair kinetics in Arabidopsis plants.

    Science.gov (United States)

    Charbonnel, Cyril; Gallego, Maria E; White, Charles I

    2010-10-01

    Double-strand breakage (DSB) of DNA involves loss of information on the two strands of the DNA fibre and thus cannot be repaired by simple copying of the complementary strand which is possible with single-strand DNA damage. Homologous recombination (HR) can precisely repair DSB using another copy of the genome as template and non-homologous recombination (NHR) permits repair of DSB with little or no dependence on DNA sequence homology. In addition to the well-characterised Ku-dependent non-homologous end-joining (NHEJ) pathway, much recent attention has been focused on Ku-independent NHR. The complex interrelationships and regulation of NHR pathways remain poorly understood, even more so in the case of plants, and we present here an analysis of Ku-dependent and Ku-independent repair of DSB in Arabidopsis thaliana. We have characterised an Arabidopsis xrcc1 mutant and developed quantitative analysis of the kinetics of appearance and loss of γ-H2AX foci as a tool to measure DSB repair in dividing root tip cells of γ-irradiated plants in vivo. This approach has permitted determination of DSB repair kinetics in planta following a short pulse of γ-irradiation, establishing the existence of a Ku-independent, Xrcc1-dependent DSB repair pathway. Furthermore, our data show a role for Ku80 during the first minutes post-irradiation and that Xrcc1 also plays such a role, but only in the absence of Ku. The importance of Xrcc1 is, however, clearly visible at later times in the presence of Ku, showing that alternative end-joining plays an important role in DSB repair even in the presence of active NHEJ. © 2010 The Authors. Journal compilation © 2010 Blackwell Publishing Ltd.

  15. ELBERETH. A subroutine library for graphic representation from J. E. N. Fusion Division; ELBERETH. Libreria de subrutinas para representacion grafica de la Division de Fusion de la JEN

    Energy Technology Data Exchange (ETDEWEB)

    Guasp, J

    1981-07-01

    A library for graphic representation, named ELBERETH, has been built, all the subroutines have been written in FORTRAN-V for the UN IVAC-1100/80 computers from JEN and are able to produce drawing on the CALCOMP-936 plotter, as well as with the printers and on the UTS-400 terminal screen. The library can yield two or three-dimensional plots as rail as level lines, all of them under free format or in several standard ones either. It allows to be used on a simplified way by direct reading from a file. It has been constructed too with a flexible structure to allow forth coming extensions. (Author) 4 refs.

  16. Experimental research on Ku-band magnetically insulated transmission line oscillator

    Energy Technology Data Exchange (ETDEWEB)

    Jiang, Tao; Zhang, Jiande; He, Juntao; Li, Zhiqiang; Ling, Junpu [College of Optoelectric Science and Engineering, National University of Defense Technology, Hunan 410073 (China)

    2015-10-15

    An improved Ku-band magnetically insulated transmission line oscillator is proposed and investigated experimentally. In the particle-in-cell simulation, the Ku-band MILO generates the microwave with a power of 1.62 GW and a frequency of 13 GHz at the input voltage of 474 kV. The device is fabricated based on the simulation results, and an experiment system is designed. In the preliminary experiments, output microwave with frequency of 13.02 GHz, power of 150 MW, and pulse width of 17 ns is generated, under the diode voltage of 450 kV. Analysis on the experiment results shows that plasma produced due to the large current hitting to the outside of the collection tank is the essential cause for the low amplitude of the microwave power and short pulse width.

  17. Alterations in cellular energy metabolism associated with the antiproliferative effects of the ATM inhibitor KU-55933 and with metformin.

    Directory of Open Access Journals (Sweden)

    Mahvash Zakikhani

    Full Text Available KU-55933 is a specific inhibitor of the kinase activity of the protein encoded by Ataxia telangiectasia mutated (ATM, an important tumor suppressor gene with key roles in DNA repair. Unexpectedly for an inhibitor of a tumor suppressor gene, KU-55933 reduces proliferation. In view of prior preliminary evidence suggesting defective mitochondrial function in cells of patients with Ataxia Telangiectasia (AT, we examined energy metabolism of cells treated with KU-55933. The compound increased AMPK activation, glucose uptake and lactate production while reducing mitochondrial membrane potential and coupled respiration. The stimulation of glycolysis by KU-55933 did not fully compensate for the reduction in mitochondrial functions, leading to decreased cellular ATP levels and energy stress. These actions are similar to those previously described for the biguanide metformin, a partial inhibitor of respiratory complex I. Both compounds decreased mitochondrial coupled respiration and reduced cellular concentrations of fumarate, malate, citrate, and alpha-ketogluterate. Succinate levels were increased by KU-55933 levels and decreased by metformin, indicating that the effects of ATM inhibition and metformin are not identical. These observations suggest a role for ATM in mitochondrial function and show that both KU-55933 and metformin perturb the TCA cycle as well as oxidative phosphorylation.

  18. Trajectory resolved analysis of LEIS energy spectra: Neutralization and surface structure

    International Nuclear Information System (INIS)

    Beikler, Robert; Taglauer, Edmund

    2001-01-01

    For a quantitative evaluation of low-energy ion scattering (LEIS) data with respect to surface composition and structure a detailed analysis of the energy spectra is required. This includes the identification of multiple scattering processes and the determination of ion survival probabilities. We analyzed scattered ion energy spectra by using the computer code MARLOWE for which we developed a new analysis routine that allows to record energy distributions in dependence of the number of projectile-target atom collisions, in dependence of the distance of closest approach, or in dependence of the scattering crystalline layer. This procedure also permits the determination of ion survival probabilities by applying simple collision-dependent neutralization models. Experimental energy spectra for various projectile (He + , Ne + , Na + ) and target (transition metals, oxides) combinations are well reproduced and quantitative results for ion survival probabilities are obtained. These are largely in agreement with results obtained for bimetallic crystal surfaces obtained in a different way. Such MARLOWE calculations are also useful for the identification of structure relevant processes. This is shown exemplarily for the reconstructed Au(1 1 0) surface including a possibility to determine the (1x2)→(1x1) transition temperature

  19. Sobre a relação entre Rei, Lei e Parlamento no Antigo Regime

    Directory of Open Access Journals (Sweden)

    Alexander Martins Vianna

    2010-09-01

    Full Text Available Este ensaio pretende desenvolver um entendimento sobre as relações mutáveis entre Rei, Lei e Parlamento na Inglaterra, entre a “Grande Matéria” (1532-1535 de Henrique VIII e a Guerra Civil Inglesa (meados do século XVII, que as situe adequadamente nos caracteres institucionais (práticos e doutrinais do Antigo Regime, rompendo com a chave de leitura da historiografia liberal que, desde o século XIX, tende a essencializar uma espécie de distinção histórica entre Inglaterra e França, como se fossem protótipos, respectivamente, de “contratualismo” e “absolutismo”.

  20. Várias Marias: efeitos da Lei Maria da Penha nas delegacias

    Directory of Open Access Journals (Sweden)

    Roberta Carvalho Romagnoli

    2015-08-01

    Full Text Available Este artigo discute os dados qualitativos da pesquisa “Violência Doméstica perpetrada contra a mulher no município de Montes Claros: um recorte possível”, financiada pelo CNPq e pela FAPEMIG. O objetivo do estudo foi investigar quantitativamente e qualitativamente os atos violentos contra as mulheres na cidade de Montes Claros, Minas Gerais. A vertente qualitativa pretendia conhecer o sentido da violência para as mulheres envolvidas e seus reflexos na família, através de entrevistas semiestruturadas que não se efetivaram. A partir da Análise Institucional de René Lourau analisamos essa inviabilidade como dado qualitativo, examinando o cotidiano da delegacia após a lei Maria da Penha. Concluímos que a intervenção judicial não é suficiente para a inibição da violência contra a mulher, pois em certos casos afasta da delegacia mulheres com outras demandas acerca da violência, que sofrem e que não podem contar com a ajuda policial para a resolução dos seus conflitos.

  1. LEAN OFFICE E AS CINCO LEIS DA BIBLIOTECONOMIA: possibilidades para gestão de bibliotecas

    Directory of Open Access Journals (Sweden)

    Moisés da Silva Cabete

    2016-08-01

    Full Text Available O objetivo deste artigo é discutir o alinhamento entre o lean office e as cinco leis da biblioteconomia na perspectiva de gerar novas formas de gestão para sistemas de bibliotecas. Optou-se pela escolha do método tipo survey, que avalia uma amostra significativa de um problema a ser investigado a fim de extrair conclusões acerca dessa amostra. A coleta de dados contou com a participação de vinte bibliotecários gestores da cidade de Manaus, que responderam um questionário com dez perguntas do tipo likert. Para a análise dos dados utilizou-se a média ponderada e uma escala com base na média de pontuação de aceitação dos respondentes.  Como resultado, percebe-se um alto nível de concordância do objeto pesquisado, proporcionando a abertura de discussão sobre novos caminhos estratégicos de gestão que levem ao aprimoramento de serviços e sistemas de unidades de informação como as bibliotecas.

  2. Trajetórias escolares de adolescentes em conflito com a lei

    Directory of Open Access Journals (Sweden)

    Marina Rezende Bazon

    2013-06-01

    Full Text Available O objetivo do presente estudo foi descrever o percurso e caracterizar as trajetórias escolares de adolescentes em conflito com a lei no tocante às suas experiências educacionais. Participaram seis adolescentes em cumprimento de Medida Socioeducativa e seus respectivos responsáveis. Coletaram-se informações em 22 estabelecimentos educacionais frequentados pelos mesmos, desde o início de suas vidas escolares, em complementação às entrevistas semiestruturadas realizadas. A análise qualitativa indicou a existência de dois padrões de trajetórias de escolarização, sendo um marcado pela descontinuidade na qualidade das vivências escolares, com um período inicial positivo, que torna-se negativo em seguida; e outro, cuja marca é a continuidade preponderantemente negativa da experiência, desde o início. Implicações dessas trajetórias ao surgimento e manutenção de conduta infracional são discutidas.

  3. Fenomenologia das motivações do adolescente em conflito com a lei

    Directory of Open Access Journals (Sweden)

    Maria Clara Jost

    Full Text Available Este trabalho visa a avaliar as motivações mobilizadoras do comportamento do adolescente em conflito com a lei, adotando o conceito interativo do ato infracional. Entrevistas, individuais e semi-estruturadas, foram realizadas com adolescentes do sexo masculino, privados de liberdade. Os conteúdos obtidos foram organizados em núcleos temáticos, analisados fenomenologicamente e articulados às motivações subjacentes. Os resultados revelaram uma ambivalência vivencial que corrompe as subjetividades e fragmenta os relacionamentos intersubjetivos, forjando angústia existencial. Essa angústia se expressa em ações contra si mesmo e a sociedade. Pontua-se a necessidade de intervenções psicossociais que considerem o problema não somente a partir dos determinismos simbólicos e culturais que o engendram, mas que também incluam a busca de respostas desses adolescentes ao seu sofrimento humanístico-existencial.

  4. [Comparison of academic viewpoints between Yun Tie-qiao and Lu Yuan-lei].

    Science.gov (United States)

    Yang, Zhi-qing; Bi, Li-juan; Yang, Xing-lin

    2010-07-01

    Both Yun Tie-qiao and Lu Yuan-lei are medical professionals coming from the literary field with versatile and in-depth knowledge and extensive experience in medical education and clinical practice, all closely related to modern TCM development. Yun, the elder, insisted on reforming TCM and was early to advocate the academic idea of amalgamating western and traditional Chinese medicine; while Lu, the younger, insisted on the idea of "scientizing TCM" and was the representative of amalgamating western and traditional Chinese medicine in the later stage. They shared many common viewpoints, including venerating Zhang Zhongjing, stressing exogenous cold pathogens, advocating reformation and amalgamation of western medicine and TCM and objecting to the abolishment of TCM. However, there were discrepancies between them, including the relationship between the Inner Canon and the Essay on Exogenous Cold Diseases, warm disease theory, pulse theory, titles of TCM diseases and Japanese Kampo medicine. A comparison of them and noting their valuable contributions will be beneficial for the promotion of the development of TCM.

  5. Analysis of metals in asphaltenes of KU-46 by PIXE analysis

    International Nuclear Information System (INIS)

    Navidad G, P.; Pina L, L.I.; Lopez M, J.; Ramirez T, J.J.; Aspiazu F, J.A.; Romero G, E.T.

    2002-01-01

    The content of metals of the asphaltenes obtained from the KU-46 mexican crude with n-heptane was evaluated. The found metals in higher concentration are transition metals as well as the vanadium, nickel, copper and zinc. Moreover the sulfur in high concentrations was quantified. The metallic content of the asphaltenes revealed that the crude contains a lower quantity of metals unlike the vacuum residue previously analysed. (Author)

  6. Radiation effects on radiation-hardened KU and KS-4V optical fibres

    International Nuclear Information System (INIS)

    Ivanov, A.A.; Tugarinov, S.N.; Kaschuck, Y.A.; Krasilnikov, A.V.; Bender, S.E.

    1999-01-01

    The aim of this work was to test the un-pretreated and the hardened (H 2 -loaded and pre-irradiated) KS-4V and KU optical fibres in reactor environment by in-situ measurements of both the radiation-induced loss and the luminescence in the visible spectral region. Both the radio-luminescent and the transmission spectra were in-situ detected during irradiation by charge-coupled-device (CCD) linear detector in the visible spectral region of 400 to 700 nm. The radiation induced loss spectra at the fast neutron fluence of 2*10 6 n/cm 2 shows the hardened, H 2 -loading and pre-irradiating effects in the both KU and KS-4V fibres. KU un-pretreated fibre shows a big radiation absorption band of non-bridging oxygen centered at the wavelength of 630 nm. It appears that the KS-4V hardened fibre has a specific point in the loss spectrum in the vicinity of 460 nm. Other measurements were performed, particularly after reactor shutdown and at 3 different neutron fluences with constant neutron flux after restarting

  7. Oxidative DNA Damage in Neurons: Implication of Ku in Neuronal Homeostasis and Survival

    Directory of Open Access Journals (Sweden)

    Daniela De Zio

    2012-01-01

    Full Text Available Oxidative DNA damage is produced by reactive oxygen species (ROS which are generated by exogenous and endogenous sources and continuously challenge the cell. One of the most severe DNA lesions is the double-strand break (DSB, which is mainly repaired by nonhomologous end joining (NHEJ pathway in mammals. NHEJ directly joins the broken ends, without using the homologous template. Ku70/86 heterodimer, also known as Ku, is the first component of NHEJ as it directly binds DNA and recruits other NHEJ factors to promote the repair of the broken ends. Neurons are particularly metabolically active, displaying high rates of transcription and translation, which are associated with high metabolic and mitochondrial activity as well as oxygen consumption. In such a way, excessive oxygen radicals can be generated and constantly attack DNA, thereby producing several lesions. This condition, together with defective DNA repair systems, can lead to a high accumulation of DNA damage resulting in neurodegenerative processes and defects in neurodevelopment. In light of recent findings, in this paper, we will discuss the possible implication of Ku in neurodevelopment and in mediating the DNA repair dysfunction observed in certain neurodegenerations.

  8. DASCH ON KU Cyg: A ∼ 5 YEAR DUST ACCRETION EVENT IN ∼ 1900

    International Nuclear Information System (INIS)

    Tang Sumin; Grindlay, Jonathan; Los, Edward; Servillat, Mathieu

    2011-01-01

    KU Cyg is an eclipsing binary consisting of an F-type star accreting through a large accretion disk from a K5III red giant. Here we present the discovery of a 5 year dip around 1900 found from its 100 year DASCH light curve. It showed a ∼0.5 mag slow fading from 1899 to 1903 and brightened back around 1904 on a relatively shorter timescale. The light curve shape of the 1899-1904 fading-brightening event differs from the dust production and dispersion process observed in R Coronae Borealis stars, which usually has a faster fading and slower recovery, and for KU Cyg is probably related to the accretion disk surrounding the F star. The slow fading in KU Cyg is probably caused by increases in dust extinction in the disk, and the subsequent quick brightening may be due to the evaporation of dust transported inward through the disk. The extinction excess which caused the fading may arise from increased mass transfer rate in the system or from dust clump ejections from the K giant.

  9. SOBRE A INTERFERÊNCIA NECESSÁRIA DA VOZ NA LEI : O EXEMPLO DA TRAGÉDIA ANTIGA

    Directory of Open Access Journals (Sweden)

    Jean-Michel Vivès

    2013-02-01

    Full Text Available Nessa conferência, proferida especialmente pelo autor a convite da Comissão Científica do Colóquio Internacional « A Psicanálise e a Lei »  é abordada a estrutura da tragédia antiga retomada a partir do entendimento que dela faz Claudel, na medida em que destaca a sua dimensão essencialmente vocal. Partindo da definição dada, pelo citado poeta, da tragédia como um  « long cri devant une tombe mal fermée », o autor procura dela tirar todas as consequências para pensar as questões referentes à voz e a lei naquilo que diz respeito à clinica psicanalítica. Leva ainda em consideração as contribuições de Nietzsche, acerca do nascimento da tragédia, e de Loraux que também chama a atenção para a dimensão vocal da tragédia, pondo em Nessa conferência, proferida especialmente pelo autor a convite da Comissão Científica do Colóquio Internacional « A Psicanálise e a Lei »  é abordada a estrutura da tragédia antiga retomada a partir do entendimento que dela faz Claudel, na medida em que destaca a sua dimensão essencialmente vocal. Partindo da definição dada, pelo citado poeta, da tragédia como um  « long cri devant une tombe mal fermée », o autor procura dela tirar todas as consequências para pensar as questões referentes à voz e a lei naquilo que diz respeito à clinica psicanalítica. Leva ainda em consideração as contribuições de Nietzsche, acerca do nascimento da tragédia, e de Loraux que também chama a atenção para a dimensão vocal da tragédia, pondo em evidencia sua dimensão política. O tratamento dessas questões levam o autor a formular a hipótese: a instauração e a relação à lei, que é uma das questões essenciais apresentadas pela tragédia, não poderia ser pensada ao redor de sua relação à voz ?

  10. ”KELPAANKO MÄ TÄLLAISENA KUIN OLEN?” : 13–17-vuotiaiden tyttöjen ajatuksia ulkonäöstä ja ulkonäköpaineista

    OpenAIRE

    Saikkonen, Heini; Rytilahti, Laura

    2017-01-01

    Rytilahti, Laura & Saikkonen, Heini. ”Kelpaanko mä tällaisena kuin olen?”. 13–17-vuotiaiden tyttöjen ajatuksia ulkonäöstä ja ulkonäköpaineista. Helsinki, kevät 2017, 57 s., 3 liitettä. Diakonia-ammattikorkeakoulu. Hoitotyön koulutusohjelma, sairaanhoitaja (AMK). Opinnäytetyö toteutettiin yhteistyössä Helsingin Tyttöjen Talon kanssa. Tutkimuksen tarkoituksena oli selvittää nuorten tyttöjen ajatuksia ulkonäöstä ja ulkonäköpaineista. Tutkimuksen avulla haluttiin selvittää nuorten mahdollisi...

  11. Edward W. Jennings | NREL

    Science.gov (United States)

    practices promoting a safe and supportive working environment. His research interests include environmental, safety, and health (ESH) and facility issues, he is responsible for implementing safe work plan; working directly with awardees by performing on-site validations to collect and analyze enzyme

  12. Serum anti-Ku86 is a potential biomarker for early detection of hepatitis C virus-related hepatocellular carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Nomura, Fumio, E-mail: fnomura@faculty.chiba-u.jp [Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University and Divisions of Laboratory Medicine, Clinical Genetics and Proteomics, Chiba University Hospital, Chiba (Japan); Sogawa, Kazuyuki; Noda, Kenta; Seimiya, Masanori; Matsushita, Kazuyuki; Miura, Toshihide [Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University and Divisions of Laboratory Medicine, Clinical Genetics and Proteomics, Chiba University Hospital, Chiba (Japan); Tomonaga, Takeshi [Laboratory of Proteome Research, National Institute of Biomedical Innovation, Ibaraki (Japan); Yoshitomi, Hideyuki [Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba (Japan); Imazeki, Fumio [Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba (Japan); Takizawa, Hirotaka [Kashiwado Clinic in Port-Square of the Kashiwado Memorial Foundation, Chiba (Japan); Mogushi, Kaoru [Information Center for Medical Sciences, Tokyo Dental and Medical University, Tokyo (Japan); Miyazaki, Masaru [Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba (Japan); Yokosuka, Osamu [Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba (Japan)

    2012-05-18

    Highlights: Black-Right-Pointing-Pointer Overexpression of Ku86 in human liver cancer was shown by immunohistochemistry. Black-Right-Pointing-Pointer Serum anti-Ku86 was significantly elevated in early hepatocellular carcinoma. Black-Right-Pointing-Pointer Anti-Ku86 may be more sensitive than the conventional markers for early detection. Black-Right-Pointing-Pointer Serum anti-Ku86 significantly decreased after surgical resection of liver tumors. Black-Right-Pointing-Pointer Elevation of serum anti-Ku86 in other non-liver solid tumors was minimal. -- Abstract: Hepatocellular carcinoma (HCC), the predominant form of primary liver cancer, is one of the most common cancers worldwide and the third most common cause of cancer-related death. Imaging studies including ultrasound and computed tomography are recommended for early detection of HCC, but they are operator dependent, costly and involve radiation. Therefore, there is a need for simple and sensitive serum markers for the early detection of hepatocellular carcinoma (HCC). In our recent proteomic studies, a number of proteins overexpressed in HCC tissues were identified. We thought if the serum autoantibodies to these overexpressed proteins were detectable in HCC patients. Of these proteins, we focused on Ku86, a nuclear protein involved in multiple biological processes and aimed to assess the diagnostic value of serum anti-Ku86 in the early detection of HCC. Serum samples were obtained prior to treatment from 58 consecutive patients with early or relatively early hepatitis C virus (HCV)-related HCC and 137 patients with HCV-related liver cirrhosis without evidence of HCC. Enzyme immunoassays were used to measure serum levels of autoantibodies. Serum levels of anti-Ku86 antibodies were significantly elevated in HCC patients compared to those in liver cirrhosis patients (0.41 {+-} 0.28 vs. 0.18 {+-} 0.08 Abs at 450 nm, P < 0001). Setting the cut-off level to give 90% specificity, anti-Ku86 was positive in 60.7% of

  13. Molecular characterization of resistant chronic lymphocytic leukemia (CLL): function of a new phosphorylated form of Ku70

    International Nuclear Information System (INIS)

    Saad, Lina

    2013-01-01

    We have identified a new form of phospho-S27-S33-Ku70 constitutively over expressed in a subset of chronic lymphocytic leukemia (CLL) B cells resistant to apoptosis induced by DNA double strand breaks (DSB). Ku70 is one of the essential proteins involved in the maintenance of genomic stability through its role in DNA double strand break repair (non-homologous end-joining, NHEJ) and in telomeric protection. Laboratory previously established that resistant CLL cells disclose an up-regulated NHEJ DNA repair and an impaired structure of telomeres. The goal of this thesis was to characterize the biological function(s) of this new form of Ku70. For this purpose we have constructed specific EBV-based vectors (siRNA / cDNA) enabling a simultaneous inhibition of endogenous Ku70 and an expression of different forms (mutated, wild, phospho-mimetic at ser27-33) of Ku70 resistant to siRNA. Thus, we showed: i) a strict co-localisation of phospho-Ku70 with γ-H2AX foci; ii) that DSB induces the phosphorylation of Ku70 within minutes after genotoxic stress in heterodimer complex Ku70/Ku80. This phosphorylation necessitates both the physical interaction and the activity of pS2056-DNA-PKcs and/or ATM, linking phospho-Ku70 to NHEJ-mediated DNA DSB repair; iii) cells expressing mutated A27-A33-Ku70 exhibit a delayed G2/M cell cycle arrest, slower kinetic of DNA repair, lower level of genotoxic stress-induced chromosomal aberrations, and a higher cellular impedance correlated with translocation of transcriptional factor β-catenin from cytoplasmic membrane to the nucleus. Together, these data unveil an involvement of phospho-Ku70 in fast and inaccurate DNA repair; new paradigm for NHEJ regulation and to the control of resistance and maintenance of malignant cells.In parallel, we have initiated experimental approaches to explore other potential roles of phospho-Ku70. Especially, we were interested to determine whether it could play a role in an initiation of cell senescence induced by

  14. A tempestade global da lei e ordem: sobre punição e neoliberalismo

    Directory of Open Access Journals (Sweden)

    Loïc Wacquant

    2012-02-01

    Full Text Available Este artigo reflete sobre a recepção internacional ao livro Prisões da miséria como reveladora da expansão penal nas sociedades avançadas na década de 2000. Ele revela que a tempestade global da "lei e ordem" inspirada pelos Estados Unidos, que o livro detectou em 1999, continuou a espalhar-se por toda a parte. Na verdade, ela estendeu-se dos países do Primeiro Mundo para os do Segundo Mundo e alterou a política e as práticas de punição em todo o globo de uma forma que ninguém previa e que ninguém teria pensado como possível há cerca de 15 anos. O artigo estende a análise para o papel dos institutos de consultoria (em especial o Manhattan Institute na difusão das noções de combate ao crime e das panacéias no estilo estadunidense na América Latina como um elemento da circulação internacional dos pacotes de política pró-mercado que alimentam a gerência punitiva da pobreza. O artigo elabora e revê o modelo original do nexo entre neoliberalismo e penalidade punitiva, levando a análise da montagem do Estado na era da insegurança social, desenvolvida no livro Punindo os pobres.

  15. A Lei do Turismo – Lei 11.771 de 17 de setembro de 2008: uma breve análise

    Directory of Open Access Journals (Sweden)

    Tassiana Moura Oliveira

    2010-07-01

    -fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;}

    Resumo

    O presente artigo é fruto do trabalho de conclusão do curso de turismo da Universidade Federal de Pernambuco intitulado “Direito e Turismo: uma breve análise do projeto de lei 3.118 – A lei do turismo”. O objetivo principal é analisar brevemente a Lei do Turismo, promulgada em 17 de setembro de 2008, e suas implicações no ordenamento jurídico brasileiro. O direito dentro turismo vem sendo pouco debatido no meio acadêmico ao longo dos últimos anos e é de salutar importância compreender a dimensão que tal legislação alcançará no contexto nacional. Embora esteja na contramão da tendência mundial de desregulamentação do setor, espera-se que a Lei 11.771/2008 represente fatualmente o embasamento legal necessário para o desenvolvimento do turismo e a atividade turística possa ser tratada com seriedade pelo poder público, principalmente pelo poder executivo. Ademais, a lei viabilizará a apresentação do turismo aos juristas do país que ainda não conhecem suas especificidades.

    Palavras-chave: atividade turística; regulamentação; poder público; planejamento turístico.

     

    Pela metade: Implicações do dispositivo médico-criminal da “Nova” Lei de Drogas na cidade de São Paulo

    Directory of Open Access Journals (Sweden)

    Marcelo da Silveira Campos

    Full Text Available Resumo Este texto aborda as implicações da atual lei de drogas no Brasil, analisada como um dispositivo de poder médico-criminal. A análise está voltada, mais especificamente, para algumas implicações da lei n. 11 343 de 2006 – “Nova” Lei de Drogas – no sistema de justiça criminal na cidade de São Paulo, tendo como pano de fundo o fenômeno da intensificação do encarceramento por tráfico de drogas no país após o advento da mesma lei no ano de 2006. São apresentados dados sobre prisões por drogas no Brasil e, em seguida, utiliza-se um modelo de série temporal interrompida [interrupted time series designs] em conjunto com um modelo de regressão binária logística com dados relativos à cidade de São Paulo, para indicar como se dá a atual administração estatal das drogas e como se desenvolvem práticas no interior do sistema de justiça criminal que privilegiam a pena de prisão, mesmo depois do suposto fim desta para o usuário de drogas, com a aprovação da lei de 2006.

  16. Role of Ku80-dependent end-joining in delayed genomic instability in mammalian cells surviving ionizing radiation

    International Nuclear Information System (INIS)

    Suzuki, Keiji; Kodama, Seiji; Watanabe, Masami

    2010-01-01

    Ionizing radiation induces delayed destabilization of the genome in the progenies of surviving cells. This phenomenon, which is called radiation-induced genomic instability, is manifested by delayed induction of radiation effects, such as cell death, chromosome aberration, and mutation in the progeny of cells surviving radiation exposure. Previously, there was a report showing that delayed cell death was absent in Ku80-deficient Chinese hamster ovary (CHO) cells, however, the mechanism of their defect has not been determined. We found that delayed induction of DNA double strand breaks and chromosomal breaks were intact in Ku80-deficient cells surviving X-irradiation, whereas there was no sign for the production of chromosome bridges between divided daughter cells. Moreover, delayed induction of dicentric chromosomes was significantly compromised in those cells compared to the wild-type CHO cells. Reintroduction of the human Ku86 gene complimented the defective DNA repair and recovered delayed induction of dicentric chromosomes and delayed cell death, indicating that defective Ku80-dependent dicentric induction was the cause of the absence of delayed cell death. Since DNA-PKcs-defective cells showed delayed phenotypes, Ku80-dependent illegitimate rejoining is involved in delayed impairment of the integrity of the genome in radiation-survived cells.

  17. Double strand break rejoining by the Ku-dependent mechanism of non-homologous end-joining

    International Nuclear Information System (INIS)

    Jeggo, P.; Singleton, B.; Beamish, H.; Priestley, A.

    1999-01-01

    The DNA-dependent protein kinase functions in the repair of DNA double strand breaks (DSBs) and in V(D)J recombination. To gain insight into the function of DNA-PK in this process we have carried out a mutation analysis of Ku80 and DNA-PKcs. Mutations at multiple sites within the N-terminal two thirds of Ku80 result in loss of Ku70/80 interaction, loss of DNA end-binding activity and inability to complement Ku80 defective cell fines. In contrast, mutations in the carboxy terminal region of the protein do not impair DNA end-binding activity but decrease the ability of Ku to activate DNA-PK. To gain insight into important functional domains within DNA-PKcs, we have analysed defective mutants, including the mouse scid cell line, and the rodent mutants, ire-20 and V-3. Mutational changes in the carboxy terminal region have been identified in all cases. Our results strongly suggest that the C-terminus of DNA-PKcs is required for kinase activity. (author)

  18. Role of Ku80-dependent end-joining in delayed genomic instability in mammalian cells surviving ionizing radiation

    Energy Technology Data Exchange (ETDEWEB)

    Suzuki, Keiji, E-mail: kzsuzuki@nagasaki-u.ac.jp [Course of Life Sciences and Radiation Research, Graduate School of Biomedical Sciences, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523 (Japan); Kodama, Seiji [Research Institute for Advanced Science and Technology, Osaka Prefecture University, 1-2 Gakuen-machi, Sakai 599-8570 (Japan); Watanabe, Masami [Kyoto University Research Reactor Institute, Kumatori-cho Sennan-gun, Osaka 590-0494 (Japan)

    2010-01-05

    Ionizing radiation induces delayed destabilization of the genome in the progenies of surviving cells. This phenomenon, which is called radiation-induced genomic instability, is manifested by delayed induction of radiation effects, such as cell death, chromosome aberration, and mutation in the progeny of cells surviving radiation exposure. Previously, there was a report showing that delayed cell death was absent in Ku80-deficient Chinese hamster ovary (CHO) cells, however, the mechanism of their defect has not been determined. We found that delayed induction of DNA double strand breaks and chromosomal breaks were intact in Ku80-deficient cells surviving X-irradiation, whereas there was no sign for the production of chromosome bridges between divided daughter cells. Moreover, delayed induction of dicentric chromosomes was significantly compromised in those cells compared to the wild-type CHO cells. Reintroduction of the human Ku86 gene complimented the defective DNA repair and recovered delayed induction of dicentric chromosomes and delayed cell death, indicating that defective Ku80-dependent dicentric induction was the cause of the absence of delayed cell death. Since DNA-PKcs-defective cells showed delayed phenotypes, Ku80-dependent illegitimate rejoining is involved in delayed impairment of the integrity of the genome in radiation-survived cells.

  19. The Ku70/80 ring in Non-Homologous End-Joining: easy to slip on, hard to remove.

    Science.gov (United States)

    Kragelund, Birthe B; Weterings, Eric; Hartmann-Petersen, Rasmus; Keijzers, Guido

    2016-01-01

    Non-homologous end-joining (NHEJ) is an essential DNA double strand break repair pathway during all cell cycle stages. Deficiency in NHEJ factors can lead to accumulation of unrepaired DNA breaks or faulty DNA repair, which may ultimately result in cell death, senescence or carcinogenesis. The Ku70/80 heterodimer is a key-player in the NHEJ pathway and binds to DNA termini with high affinity, where it helps to protect DNA ends from degradation and to recruit other NHEJ factors required for repair. The mechanism of Ku70/80 detachment from the DNA helix after completion of DNA repair is incompletely understood. Some data suggest that certain DNA repair factors are ubiquitylated and targeted for proteasomal degradation after repair. Recent studies suggest that Ku80 is conjugated to lysine48-linked ubiquitin chains by the Skp1-Cullin-F-box (SCF) complex and/or the RING finger protein 8 (RNF8) ubiquitin-protein ligases, followed by rapid proteasomal degradation. In this review we address the structure and function of the Ku70/80 heterodimer and how ubiquitylation may affect the release of Ku70/80 from chromatin and its subsequent degradation via the ubiquitin-proteasome system.

  1. Síndrome de alienação parental: da teoria Norte-Americana à nova lei brasileira

    Directory of Open Access Journals (Sweden)

    Analícia Martins de Sousa

    Full Text Available A síndrome de alienação parental (SAP foi definida, na década de 1980, pelo psiquiatra norteamericano Richard Gardner, como um distúrbio infantil que acometeria crianças e adolescentes envolvidos em situações de disputa de guarda entre os pais. Na visão do autor, a síndrome se desenvolve a partir de programação ou lavagem cerebral realizada por um genitor - nomeado como alienador - para que a criança rejeite o outro responsável. No Brasil, após rápida tramitação no Legislativo, foi sancionada, em agosto de 2010, lei sobre a alienação parental, que prevê sanções ao genitor que causar impedimentos à convivência do(s filho(s com o outro responsável. A nova lei traz determinações quanto à atuação de psicólogos no exame de supostos casos de alienação parental, destacando também os aspectos emocionais observados em tais situações. No presente artigo, tem-se como proposta examinar - à luz dos conhecimentos da Psicologia - os argumentos, ligados a essa área, que fundamentaram a exposição de motivos do projeto de lei sobre a alienação parental, explanando-se também as decisões judiciais proferidas em diferentes países que tomaram por base esse conceito.

  2. Amostragem seqüencial com base na lei de Taylor para levantamento de Spodoptera frugiperda na cultura do milho

    Directory of Open Access Journals (Sweden)

    Farias Paulo Roberto Silva

    2001-01-01

    Full Text Available A lagarta do cartucho do milho é uma das principais pragas do milho nas Américas, podendo ocorrer durante todos os estágios de crescimento da cultura, causando perdas de 15 a 37% na produção. Neste trabalho estudou-se a distribuição espacial dessa praga no campo, com a finalidade de desenvolver um sistema de amostragem para estimar sua densidade populacional. Na área cultivada com milho foram selecionados 3 campos experimentais de 40 m x 250 m cada, divididos em 100 parcelas cada. Foram contados o número de lagartas pequenas e grandes de S. frugiperda nas folhas e no cartucho das plantas, em 10 plantas ao acaso por parcela, num total de 1000 plantas por campo, em 5, 5 e 4 datas de amostragem, respectivamente. Lagartas menores que 1 cm eram consideradas pequenas e lagartas maiores que 1 cm, grandes. Foram estimados os parâmetros da lei de Taylor, sendo as estimativas dos parâmetros das regressões altamente significativas para todas as categorias larvais. O parâmetro b da lei de Taylor para lagarta pequena foi igual a 1,57, indicando que a forma de distribuição dessa categoria larval é agregada. Para lagartas grandes o parâmetro b foi igual a 0,79, o que conduz a um tipo de distribuição tendendo para aleatoriedade. Para o número total de lagartas os resultados são equivalentes aos obtidos para lagartas pequenas. Foi desenvolvido um plano de amostragem seqüencial com base nos parâmetros da lei de Taylor.

  3. Estética e simetria na mecânica : o caso das leis de Newton

    OpenAIRE

    Ferreira Pires, Flaviston

    2017-01-01

    Destacamos a busca das bases estéticas e simétricas nos princípios que fundamentam a física, de natureza ontológica, relacionadas à homogeneidade e isotropia do espaço e à irreversibilidade do tempo, as quais são essenciais para compreender seus três princípios fundamentais: o da conservação do momento linear, do angular e da energia, presentes nas leis de Newton. Realizamos uma pesquisa bibliográfica e uma revisão historiográfica buscando identificar alguns pressupostos estéticos na fundamen...

  4. Pela reinterpretação da Lei de Anistia: a sociedade brasileira aguarda justiça

    Directory of Open Access Journals (Sweden)

    Diogo Mamoru Ide

    2008-11-01

    Full Text Available

    A análise visa argumentar que a interpretação

    predominante da Lei de Anistia brasileira é

    incompatível com o regime internacional de direitos

    humanos.

  5. [Study on processing adjuvant medicines in Lei Gong's treatise on preparation and broiling of materia medica (Leigong Paozhi Lun)].

    Science.gov (United States)

    Zhang, Wei; Zhang, Ruixian

    2010-09-01

    There were 268 kinds of medicines recorded in the book of Lei Gong's Treatise on preparation and broiling of materia medica (Leigong Paozhi Lun). Among these medicines, 178 medicines were prepared with adjuvant medicines, including general and special compatible adjuvant medicines. These adjuvant medicines used in this book can be explained by the theory of "seven-relation compatibility". The author tried to explain the usage and their compatibility of these adjuvant medicines and put forward that attention should be paid to the changes in functions of medicines and the influences of society should be paid attention.

  6. Demonstração Geométrica á da Perspectiva Exata pelas Leis da Ótica

    Directory of Open Access Journals (Sweden)

    Júlio Roberto Katinsky

    1995-04-01

    Full Text Available Em prévios estudos sobre perspectiva, apresentamos um aparelho mais simples que aqueles descritos pelos discípulos de Brunelleschi e a ele atribuídos, com o qual foi possível deduzir empiricamente as leis fundamentais da perspectiva exata, como derivadas da reflexão de espelhos planos. Neste estudo, seguimos um caminho inverso: deduzimos geometricamente a partir da ótica de Descartes e Huygens, a imagem de objetos no plano dos espelhos. Fica assim estabelecida a perspectiva exata como etapa necessária entre a ótica medieval e a ótica moderna

  7. Adolescência em Conflito com a Lei: A Intensidade da História de Vida em Ato

    OpenAIRE

    Tomasi,Laura Oliveira; Macedo,Mônica Medeiros Kother

    2015-01-01

    A pesquisa aborda o ato infracional a partir da história de vida de adolescentes em conflito com a lei e dos significados atribuídos por eles aos atos cometidos. Realizaram-se entrevistas semiestruturadas com quatro adolescentes com processo judicial em andamento devido a atos transgressivos. Os dados foram analisados por meio da Análise de Conteúdo e interpretados com aportes da Psicanálise. Quatro categorias finais constataram, na história de vida dos jovens, vivências extremas e recorrente...

  8. Decree-Law No. 48568 of 4 September 1968 - Competence of the J.E.N. to undertake scientific and technical inspections of private or public bodies involved in nuclear research or nuclear activities

    International Nuclear Information System (INIS)

    1968-01-01

    Under this Decree-Law, the Junta de Energia Nuclear (JEN) is empowered to inspect on a regular basis all establishments and installations involved in nuclear activities. These inspections are made to ensure that the installations are operated safely and efficiently and that radiation protection measures are properly applied. (NEA) [fr

  9. Izrada 3D modela kućišta centrifugalne pumpe

    OpenAIRE

    Hršak, Božidar; Golubić, Stjepan; Carek, Dalibor

    2012-01-01

    Prikazana je izrada 3D modela kućišta centrifugalne pumpe na temelju postojećeg 2D nacrta gotovog proizvoda primjenom sinkrone tehnologije 3D modeliranja, i reverzibilnog inženjeringa. Na temelju kreiranog 3D modela, predložene su moguće modifikacije postojeće izvedbe proizvoda. Provedene su analize zakrivljenosti površina, Bézierove krivulje modela i 3D geometrije. Prikazana je i mogućnost vizualizacije gotovog 3D modela na Web stranicama u cilju prezentiranja proizvoda budućim kupcima primj...

  10. Izrada 3D modela kućišta ravnog ventila DN 50

    OpenAIRE

    Hršak, Božidar; Golubić, Stjepan; Bošnjak, Matej

    2012-01-01

    Prikazana je izrada 3D modela kućišta centrifugalne pumpe na temelju postojećeg 2D nacrta gotovog proizvoda primjenom sinkrone tehnologije 3D modeliranja, i reverzibilnog inženjeringa. Na temelju kreiranog 3D modela, predložene su moguće modifikacije postojeće izvedbe proizvoda. Provedene su analize zakrivljenosti površina, Bézierove krivulje modela i 3D geometrije. Prikazana je i mogućnost vizualizacije gotovog 3D modela na Web stranicama u cilju prezentiranja proizvoda budućim kupcima primj...

  11. Chemical compatibility study of Cooley L18KU, Herculite, and Elephant Mat with Hanford tank waste

    International Nuclear Information System (INIS)

    Mercado, J.E.

    1998-01-01

    An independent chemical compatibility review of various wrapping and absorbent/padding materials was conducted to evaluate resistance to chemicals and constituents present in liquid waste from the Hanford underground tanks. These materials will be used to wrap long-length contaminated equipment when such equipment is removed from the tanks and prepared for transportation and subsequent disposal or storage. The materials studied were Cooley L18KU, Herculite, and Elephant Mat. The study concludes that these materials are appropriate for use in this application

  12. Shuttle Ku-band bent-pipe implementation considerations. [for Space Shuttle digital communication systems

    Science.gov (United States)

    Batson, B. H.; Seyl, J. W.; Huth, G. K.

    1977-01-01

    This paper describes an approach for relay of data-modulated subcarriers from Shuttle payloads through the Shuttle Ku-band communications subsystem (and subsequently through a tracking and data relay satellite system to a ground terminal). The novelty is that a channel originally provided for baseband digital data is shown to be suitable for this purpose; the resulting transmission scheme is referred to as a narrowband bent-pipe scheme. Test results demonstrating the validity of the narrowband bent-pipe mode are presented, and limitations on system performance are described.

  13. Analysis of Standards Efficiency in Digital Television Via Satellite at Ku and Ka Bands

    Directory of Open Access Journals (Sweden)

    Landeros-Ayala Salvador

    2013-06-01

    Full Text Available In this paper, an analysis on the main technical features of digital television standards for satellite transmission is carried out. Based on simulations and link budgets, the standard with the best operational performance is defined, based on simulations and link budget analysis, as well as a comparative efficiency analysis is conducted for the Ku and Ka bands for both transparent and regenerative transponders in terms of power, bandwidth, information rate and link margin, including clear sky, uplink rain, downlink rain and rain in both.

  14. Dificuldades dos alunos na aprendizagem da Lei de Ampère, à luz da teoria dos modelos mentais de Johnson-Laird

    Directory of Open Access Journals (Sweden)

    Moreira Marco Antonio

    2003-01-01

    Full Text Available Este trabalho procurou detectar quais as dificuldades mais freqüentes que alunos de Física Geral têm na aprendizagem da Lei de Ampère, visando interpretar as mesmas com base na Teoria dos Modelos Mentais de Johnson-Laird. Foram pesquisados cerca de 230 estudantes, dos cursos de Engenharia e Matemática da UFRGS, ao longo de dois semestres letivos, por meio de suas respostas a questões e problemas envolvendo a Lei de Ampère. Ficou evidente que os alunos resolvem os problemas mecanicamente e respondem a questões descritivas da mesma forma, o que forneceu dados para levantar as dificuldades relacionadas a esse mecanicismo, que se traduzem em interpretações incompletas e/ou equivocadas da Lei de Ampère, objeto de nossa análise.

  15. Lei e legalidade na Cidade do México: Estado e Direito como pratica social. Um juzgado cívico no México, Distrito Federal

    OpenAIRE

    Natália Rivera Hoyos

    2015-01-01

    Em diálogo com um debate que questiona a fortaleza do Estado de direito e o lugar da ordem legal na construção de um regime democrático, esta pesquisa analisa o fundamento e o funcionamento da Lei de Cultura Cívica da Cidade do México. A Lei de Cultura Cívica é uma lei que, desde 2004, regula o uso do espaço público (práticas, atividades, comportamentos) na capital mexicana, enquanto o juzgado cívico é a instituição na qual se processam e se determinam as conciliações, responsabilidades, infr...

  16. A pena de morte e a revolta dos escravos de Carrancas: a origem da“lei nefanda” (10 de junho de 1835

    Directory of Open Access Journals (Sweden)

    Marcos Ferreira de Andrade

    Full Text Available Resumo: O objetivo deste artigo é situar a história do surgimento da lei de 10 de junho de 1835 e destacar o impacto causado pela revolta dos escravos de Carrancas em sua formulação, considerando o teor do projeto de lei enviado à Assembleia Geral no dia 10 de junho de 1833, que culminou em sua aprovação dois anos mais tarde. Pretende-se explorar, de forma mais aprofundada, alguns aspectos da insurreição, das memórias fragmentadas construídas por políticos e memorialistas ao longo do século XIX e do debate historiográfico, que reforçam as evidências de que a revolta de Carrancas esteve, de fato, associada à origem da referida lei.

  17. O racismo escondido sob o manto da Lei / The Racism hidden under cover of law

    Directory of Open Access Journals (Sweden)

    Gustavo Távora Rodrigues

    2012-12-01

    Full Text Available RESUMO A ineficiência do combate à conduta racial no Brasil resulta da impropriedade da legislação ordinária posta, mesmo em face de expresso Mandado de Criminalização da Constituição Federal. Por consequência disso, a omissão estatal acoberta a ocorrência de criminosa conduta racial velada. Prova disso são os índices de desenvolvimento humano, que sem exceção mostram-se sempre desfavoráveis à população negra. A interpretação sistemática da Lei nº 7.716/89, diante das normas gerais do processo penal brasileiro, esvaziam a pretensão formulada pelo constituinte originário em apenar com rigor a ofensa ao bem jurídico especialmente relevante do direito a igualdade, por tratar-se de direito fundamental. No entanto, a sociedade brasileira, mesmo diante dessa inexplicável evidência no tratamento diferenciado aos seus cidadãos em razão da raça, demonstra apatia e não se importar com esta questão. Palavras-chave: Racismo, Mandado, Criminalização, Proteção, Insuficiência.     ABSTRACT The inefficiency of combat against the racist behavior in Brazil it is the result of inadequacy of ordinary legislation put even in the face of express Warrant Criminalization of the Federal Constitution. Consequently, the omission of the state encourages the occurrence of racism. Proof of this are the indices of human development, without exception show always unfavorable to the black population. The systematic interpretation of Law No. 7.716/89, according to brazilian processual criminal code, the claim made by original constituent to accurately  the offense and the legal especially relevant for the right to equality, because it is fundamental right. However, Brazilian society, even in the face of this evidence of this unexplained differential treatment to its citizens with different race, shows apathy and not caring about this question.   Keywords: Racism, Warrant, Criminalization, Protection, Inefficiency.  

  18. Lainsuojattomuudesta sukupuolineutraaliin avioliittoon – seksuaalivähemmistöjen aseman kehitys lainsäädännössä

    OpenAIRE

    Martikainen, Minna

    2016-01-01

    Tässä opinnäytetyössä tutkitaan, miten seksuaalivähemmistöjen asema Suomessa on kehittynyt lainsäädännössä varhaismodernista ajasta lähtien. Tutkimuskysymystä lähestytään lainopillisesta, oikeushistoriallisesta ja oikeussosiologisesta näkökulmasta. Opinnäytetyössä huomioidaan lakimuutosten lisäksi näin ollen myös evankelis-luterilaisen kirkon ja muiden yhteiskunnan asenteita muokkaavien tahojen sekä myös lääketieteen näkemykset. Opinnäytetyö on jaettu kolmeen päälukuun, jotka on sijoitett...

  19. Absence of hemolytic disease of fetus and newborn despite maternal high-titer IgG anti-Ku.

    Science.gov (United States)

    Kakaiya, R M; Whaley, A; Howard-Menk, C; Rami, J; Papari, M; Campbell-Lee, S; Malecki, Z

    2010-01-01

    Anti-Ku seen in K(o) (Kell-null) individuals has previously been shown to cause severe hemolytic transfusion reactions. Maternal anti-Ku can cause none or moderate to severe hemolytic disease of the fetus and newborn (HDFN). In two of four previously described HDFN cases, intrauterine transfusions were required because of severe anemia. We report a case in which maternal anti-Ku did not cause HDFN. Standard serologic methods were used for RBC antibody screening and identification, adsorption and elution of RBC antibodies, and antigen typing. A gravida 3, para 3 (G3P3) woman was first evaluated in 2006 and was found to have an IgG RBC antibody that reacted against all panel RBCs in the anti-human globulin phase. A panel of RBCs treated with DTT did not react with the antibody. The antibody failed to react with one example of K(o) RBCs. The patient’s RBCs typed negative for the following Kell blood group antigens: KEL1, KEL2, KEL3, KEL4, KEL6, KEL7, KEL11, KEL13, and KEL18. These results established the presence of anti-Ku in maternal serum. The newborn was group A, D+ and required phototherapy for hyperbilirubinemia, but did not require transfusion. The woman was seen again in January 2010 during the third trimester (G4P3). At this time, anti-Ku titer was 256. She delivered a healthy group O, D+ baby boy at 37 weeks' gestation. Cord RBCs were 4+ for IgG by DAT. An eluate reacted with all RBCs tested, but did not react when tested against a panel of DTT-treated RBCs. K(o) phenotype is rare to begin with, and the maternal anti-Ku formation may require more than one pregnancy. Therefore, cases that can be evaluated for anti-Ku–related HDFN are rare. Our case contributes to serologic and clinical aspects of such rare cases.

  20. Il mito di Ulisse nel romanzo del secondo Novecento: il tragico e l’antitragico in Stefano D’Arrigo e Walter Jens

    Directory of Open Access Journals (Sweden)

    Nora Moll

    2017-11-01

    Full Text Available In Twentieth Century’s Literature, the various declinations and rewritings of the Odysseus’ theme were conducted both in the tragic and the anti-tragic mode: the latter involving often, but not necessarily, the use of narrative strategies of parody. Referring to Hans Blumenberg (1979, we can speak of a constant “work on myth” that goes hand in hand with the development of postmodern poetics and elaboration of history, characterized by different narrative styles and strategies depending on the literary and cultural context in which they are inserted. Starting from one of the main theories about literary rewriting, as well as about mythopoetic and mythocritical discourse in twentieth century, this article aims to examine in a comparative perspective two novels, conceived almost at the same time in the Fifties, even if published separated by a distance of years. This is the "Mediterranean" novel Hocynus Orca (1975, by the Sicilian Stefano D'Arrigo, and Das Testament des Odysseus (1957, by the German writer Walter Jens, who is also known for his theoretical work on Greek mythology and tragedy. In these novels both authors choose the odyssean hypotext for liaising with the difficult legacy of World War II, but also to express its positioning in the contemporary world. The need to "complete" (Blumenberg the myth of Ulysses thus produces in D'Arrigo a reinterpretation of the novel in the epic and tragic way, while Jens escapes to the anti-tragic modus offering to its anti-hero a secondary way out from his own myth.

  1. Atingidos pela hanseníase, reparados pelo Estado : as múltiplas histórias performadas da Lei 11.520/2007

    OpenAIRE

    Glaucia Cristina Maricato Moreto

    2015-01-01

    Esta dissertação gira em torno da lei nº 11.520, que em setembro de 2007 estabeleceu o direito a uma pensão especial a todas as pessoas atingidas pela hanseníase e compulsoriamente internadas em colônias hospitalares até 31 de dezembro de 1986. Por um lado, alinhado ao trabalho de diversas pesquisadoras, tais como Vianna (2013), Bevilaqua (2013), Schuch (2008), Das e Polle (2008), Vecchioli (2001) e Ferreira (2009), o enfoque não é direcionado à letra da lei 11.520/2007 (enquanto conjunto de ...

  2. Um estudo das competências do auditor interno atuante no mercado brasileiro de seguros : percepção após a lei Sarbanes & Oxley

    OpenAIRE

    Carmona, Eduardo

    2008-01-01

    A escolha desse tema foi motivada pelo interesse pessoal do autor e por sua atuação na área, adicionalmente, as alterações ocorridas devido á publicação da lei Sarbanes & Oxley produziram grande impacto na atividade de auditoria interna em companhias de seguros. O objetivo geral da pesquisa consiste em analisar as novas competências para atender às mudanças ocorridas no mercado segurador após a lei Sarbanes & Oxley, bem como tem como objetivos específicos identificar as competências requerida...

  3. Oito Anos de Lei Maria Da Penha. Entre Avanços, Obstáculos e Desafios

    Directory of Open Access Journals (Sweden)

    Wânia Pasinato

    2015-05-01

    Full Text Available Em 2014 a Lei Maria da Penha completou oito anos. A cada ano, os eventos comemorativos de sua aprovação trazem a oportunidade de realizar balanços e reflexões sobre os avanços, obstáculos e desafios colocados à sua implementação e seus impactos sobre a universalização do acesso aos direitos e à justiça para as mulheres em situação de violência doméstica e familiar. Este artigo tem o propósito de contribuir com algumas reflexões sobre a importância do atendimento em rede para alcançar resultados mais satisfatórios na aplicação da Lei Maria da Penha. As reflexões sistematizadas utilizam resultados de pesquisas das quais participei entre 2008 e estudos realizados no período.

  4. Razão, história e justificação da lei civil segundo Thomas Hobbes

    Directory of Open Access Journals (Sweden)

    Wladimir Barreto Lisboa

    2008-09-01

    Full Text Available O autor procura analisar a relação existenteentre lei natural e lei civil em Thomas Hobbes.Para isso analisa sua crítica à história e ao commonlaw enquanto incapazes de fundar a racionalidadedo poder civil. Mostra-se igualmente de que modoo poder soberano encontra seu fundamento nas leismorais. Por fim, indica-se como a igualdade de direitos,tal como pensada na modernidade, sobretudoem Hobbes, parece inviabilizar a idéia de direitoscujos titulares seriam grupos e não indivíduos.Abstract: The author analyzes the relationbetween natural law and civil law in ThomasHobbes, pointing out Hobbes’ argument thatneither history or common law are able to foundcivil’s power rationality. The article shows, aswell, how sovereign power is founded by themoral law and how the equality of rights inHobbes seems to undermine the idea that ispossible for groups to be subject of rights insteadindividuals.

  5. A LEI 10.639 E O ENSINO DE GEOGRAFIA: CONSTRUINDO UMA AGENDA DE PESQUISA-AÇÃO

    Directory of Open Access Journals (Sweden)

    Renato Emerson dos Santos

    Full Text Available Normal 0 21 false false false PT-BR X-NONE X-NONE MicrosoftInternetExplorer4 O artigo apresenta a estrutura de um programa de pesquisa sobre a Lei 10.639 e o ensino de Geografia. Considerando o Movimento Negro como ator central na construção da Lei, busca-se retomar a complexidade de sentidos da pauta construída nos processos de disputa pela Educação enquanto instrumento da luta anti-racismo. Tal complexidade se desdobra num conjunto de cinco vertentes de investigação: (i Inserção e Revisão de conteúdos programáticos do currículo Praticado de Geografia; (ii Revisão de Práticas, Materiais e Métodos Pedagógicos; (iii Gestão das Relações Raciais no Cotidiano Escolar; (iv Relações de Poder na Construção do Currículo Praticado na Escola; (v Movimento negro, lutas na Educação e escalas da política.

  6. Brazilian law for scientific use of animals Lei Brasileira para o uso científico de animais

    Directory of Open Access Journals (Sweden)

    Ruy Garcia Marques

    2009-02-01

    Full Text Available The Brazilian scientific community claimed for a definitive systematization and for comprehensive and realistic national rules, to provide guidance and regulation, instead of sanctions, so that the question of scientific research involving animals could be better contemplated. This is beginning to occur now with Law n.º 11.794, sanctioned by the President of the Republic on November 8, 2008. PURPOSE: To describe the evolution of Brazilian regimentation for scientific use of animals and to analyze Law n.º 11.794. METHODS: The legislation about the use of animals in teaching and in scientific research in Brazil and in Rio de Janeiro State was identified and discussed. RESULTS: Until now, there was no updated general and systematizing rule regarding animal vivisection and experimentation for didactic or scientific purposes. The only specific law dates back to1979 and was not regimented. More recent laws equated the practice of scientific experiments to acts of abuse and mistreatment of animals, when alternative technology was available. Municipal laws that restricted the scientific practice of vivisection and experimentation with animals were created in the cities of Rio de Janeiro and Florianopolis. CONCLUSION: With the claim and collaboration of the scientific community, the sanction of Law n.º 11.794 regarding to the scientific use of animals represented an invaluable advance in spite of the presence of some points that eventually may require another type of treatment. The new Law states that it will be regimented within 180 (one-hundred-and-eighty days, when some of these points could be better elucidated.A comunidade científica brasileira clamava por uma norma federal abrangente e realista, mais orientadora e reguladora, e menos sancionadora, na qual a questão do uso científico dos animais pudesse ser mais bem contemplada. Isto agora começa a se materializar, com a Lei n.º 11.794, sancionada pelo Presidente da República no dia 8 de

  7. Crítica à Alteração da Lei Maria da Penha: Tutela e Responsabilidade

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    Paula Dias Moreira Penna

    2017-08-01

    Full Text Available RESUMO A Lei Maria da Penha, ao transformar os crimes contra a mulher em crimes de ação penal pública incondicionada, torna o processo contra o agressor uma iniciativa do Estado, independentemente da vontade da mulher vítima da agressão. Analisada a partir do método hermenêutico crítico e da psicanálise, sustentamos que tal mudança produz uma desresponsabilização do sujeito frente ao seu masoquismo e sustenta uma dobra ideológica que trata a mulher como infantil e passiva, naturalizando uma situação histórico-libidinal. Por fim, a conclusão apresenta a hipótese de que tal mudança na lei é perniciosa ao objetivo de criar condições sociais e libidinais para que a mulher possa responsabilizar-se, reconhecendo os fatores inconscientes envolvidos na situação de agressão.

  8. Analysis of a Compact Wideband Slotted Antenna for Ku Band Applications

    Directory of Open Access Journals (Sweden)

    M. R. Ahsan

    2014-01-01

    Full Text Available The design procedure and physical module of a compact wideband patch antenna for Ku band application are presented in this paper. Finite element method based on 3D electromagnetic field solver has been utilized for the designing and analyzing process of proposed microstrip line fed modified E-H shaped electrically small patch antenna. After successful completion of the design process through various simulations, the proposed antenna has been fabricated on printed circuit board (PCB and its characteristics have been studied. The parameters of the proposed antenna prototype have been measured in standard far-field rectangular shape anechoic measurement compartment. It is apparent from the measured antenna parameters that the proposed antenna achieved almost stable variation of radiation pattern over the entire operational band with 1380 MHz of -10 dB return loss bandwidth. The maximum gain of 7.8 dBi and 89.97% average efficiency within the operating band from 17.15 GHz to 18.53 GHz ensure the suitability of the proposed antenna for Ku band applications.

  9. Oil Slick Observation at Low Incidence Angles in Ku-Band

    Science.gov (United States)

    Panfilova, M. A.; Karaev, V. Y.; Guo, Jie

    2018-03-01

    On the 20 April 2010 the oil platform Deep Water Horizon in the Gulf of Mexico suffered an explosion during the final phases of drilling an exploratory well. As a result, an oil film covered the sea surface area of several thousand square kilometers. In the present paper the data of the Ku-band Precipitation Radar, which operates at low incidence angles, were used to explore the oil spill event. The two-scale model of the scattering surface was used to describe radar backscatter from the sea surface. The algorithm for retrieval of normalized radar cross section at nadir and the total slope variance of large-scale waves compared to the wavelength of electromagnetic wave (22 mm) was developed for the Precipitation Radar swath. It is shown that measurements at low incidence angles can be used for oil spill detection. This is the first time that the dependence of mean square slope of large-scale waves on wind speed has been obtained for oil slicks from Ku-band data, and compared to mean square slope obtained by Cox and Munk from optical data.

  10. 55K isoform of CDK9 associates with Ku70 and is involved in DNA repair

    International Nuclear Information System (INIS)

    Liu, Hongbing; Herrmann, Christine H.; Chiang, Karen; Sung, Tzu-Ling; Moon, Sung-Hwan; Donehower, Lawrence A.; Rice, Andrew P.

    2010-01-01

    Positive elongation factor b (P-TEFb) is a cellular protein kinase that is required for RNA polymerase II (RNAP II) transcriptional elongation of protein coding genes. P-TEFb is a set of different molecular complexes, each containing CDK9 as the catalytic subunit. There are two isoforms of the CDK9 protein - the major 42 KDa CDK9 isoform and the minor 55KDa isoform that is translated from an in-frame mRNA that arises from an upstream transcriptional start site. We found that shRNA depletion of the 55K CDK9 protein in HeLa cells induces apoptosis and double-strand DNA breaks (DSBs). The levels of apoptosis and DSBs induced by the depletion were reduced by expression of a 55K CDK9 protein variant resistant to the shRNA, indicating that these phenotypes are the consequence of depletion of the 55K protein and not off-target effects. We also found that the 55K CDK9 protein, but not the 42K CDK9 protein, specifically associates with Ku70, a protein involved in DSB repair. Our findings suggest that the 55K CDK9 protein may function in repair of DNA through an association with Ku70.

  11. Ku-band electromagnetic wave absorbing properties of polysiloxane derived Si-O-C bulk ceramics

    Science.gov (United States)

    Ding, Donghai; Li, Zipei; Xiao, Guoqing; Yang, Shaoyu

    2018-02-01

    The bulk Si-O-C ceramics were prepared by polymer derived ceramics (PDCs) route using polysiloxane as precursor and their properties were investigated for electromagnetic wave absorbing in the frequency range of 12.4-18 GHz (Ku-band). It was found that the catalytic pyrolysis can enhance substantially the absorbing properties by in situ formation of turbostratic carbon network, ordered carbon, and multi-wall carbon nanotubes. The matching thickness of sample containing 1.5 wt% FeCl3 (FPSO-1.5) is 2.2 mm, and its reflection loss exceeds -10 dB in the whole Ku-band with an absorption peak of -35.48 dB at 14.16 GHz. For sample containing 1.5 wt% FeCl3, its absorption peak increases to -15.78 dB, but its matching thickness decreases significantly to 2.2 mm. The polymer derived Si-O-C ceramics could be used as excellent electromagnetic functional devices working in harsh environments.

  12. A novel coaxial Ku-band transit radiation oscillator without external guiding magnetic field

    Energy Technology Data Exchange (ETDEWEB)

    Ling, Junpu, E-mail: lingjunpu@163.com; Zhang, Jiande; He, Juntao; Jiang, Tao [College of Photoelectric Science and Engineering, National University of Defense Technology, Changsha 410073 (China)

    2014-02-15

    A novel coaxial transit radiation oscillator without external guiding magnetic field is designed to generate high power microwave at Ku-band. By using a coaxial structure, the space-charge potential energy is suppressed significantly, that is good for enhancing efficient beam-wave interaction. In order to improve the transmission stability of the unmagnetized intense relativistic electron beam, a Pierce-like cathode is employed in the novel device. By contrast with conventional relativistic microwave generators, this kind of device has the advantages of high stability, non-guiding magnetic field, and high efficiency. Moreover, with the coaxial design, it is possible to improve the power-handing capacity by increasing the radial dimension of the Ku-band device. With a 550 keV and 7.5 kA electron beam, a 1.25 GW microwave pulse at 12.08 GHz has been obtained in the simulation. The power conversion efficiency is about 30%.

  13. The Ku Protein Complex Interacts with YY1, Is Up-Regulated in Human Heart Failure, and Represses α Myosin Heavy-Chain Gene Expression

    Science.gov (United States)

    Sucharov, Carmen C.; Helmke, Steve M.; Langer, Stephen J.; Perryman, M. Benjamin; Bristow, Michael; Leinwand, Leslie

    2004-01-01

    Human heart failure is accompanied by repression of genes such as α myosin heavy chain (αMyHC) and SERCA2A and the induction of fetal genes such as βMyHC and atrial natriuretic factor. It seems likely that changes in MyHC isoforms contribute to the poor contractility seen in heart failure, because small changes in isoform composition can have a major effect on the contractility of cardiac myocytes and the heart. Our laboratory has recently shown that YY1 protein levels are increased in human heart failure and that YY1 represses the activity of the human αMyHC promoter. We have now identified a region of the αMyHC promoter that binds a factor whose expression is increased sixfold in failing human hearts. Through peptide mass spectrometry, we identified this binding activity to be a heterodimer of Ku70 and Ku80. Expression of Ku represses the human αMyHC promoter in neonatal rat ventricular myocytes. Moreover, overexpression of Ku70/80 decreases αMyHC mRNA expression and increases skeletal α-actin. Interestingly, YY1 interacts with Ku70 and Ku80 in HeLa cells. Together, YY1, Ku70, and Ku80 repress the αMyHC promoter to an extent that is greater than that with YY1 or Ku70/80 alone. Our results suggest that Ku is an important factor in the repression of the human αMyHC promoter during heart failure. PMID:15367688

  14. Vecāku un bērnu mantiskās attiecības

    OpenAIRE

    Krauja, Uldis

    2009-01-01

    Bakalaura darba "Vecāku un bērna mantiskās attiecības" mērķis ir izpētīt vecāku un bērna mantisko attiecību regulējumu Latvijas Republikas normatīvajos tiesību aktos, atklājot tajos iespējamās problēmas un nepilnības. Bakalaura darba pirmajā daļā apskatīts vecāku un bērna mantisko attiecību jēdziens un izpratne, pievērsta uzmanība uz vecāku un bērna mantisko attiecību pirmsākumiem caur vēstures prizmu, lai apzinātos ģimenes tiesību nozīmīgumu cilvēces attīstībā un tagadējā dzīvē. Bakalaura da...

  15. Investigation on the performance of an optically generated RF local oscillator signal in Ku-band DVB-S systems

    NARCIS (Netherlands)

    Khan, M.R.H.; Marpaung, D.A.I.; Burla, M.; Roeloffzen, C.G.H.; Bernhardi, Edward; de Ridder, R.M.

    2011-01-01

    We investigate a way to externally generate the local oscillator (LO) signal used for downconversion of the Ku-band (10.7 − 12.75 GHz) RF signal received from a phased array antenna (PAA). The signal is then translated to an intermediate frequency (950 − 2150 MHz) at the output of the mixer of

  16. Da Dor no Corpo à Dor na Alma: O Conceito de Violências Psicológicas da Lei Maria Da Penha

    Directory of Open Access Journals (Sweden)

    Isadora Vier Machado

    2015-05-01

    Full Text Available Este artigo expõe os resultados de pesquisa de campo, realizada entre dezembro de 2010 e julho de 2011 em uma cidade do Sul do Brasil, a respeito da instrumentalização do conceito de violências psicológicas, trazido pela Lei Maria da Penha (Lei 11.340/06, a fim de construir uma leitura da lei a partir deste conceito. Os dados são referentes às/aos agentes que compõem o corpus da polícia, na Delegacia da Mulher e do Ministério Público do município, prioritariamente. Nesses locais, buscou-se compreender como o conceito de violências psicológicas é trabalhado pelas/os agentes e qual o significado teórico-prático que o subjaz. Enfim, coloca-se este dispositivo da lei em posição de questionar a sua própria implementação, de pensar as mudanças que se operam na condição de mulheres em situação de violências e de problematizar as relações entre local e global no campo estudado. A metodologia utilizada foi composta por pesquisa de inspiração etnográfica e levantamento bibliográfico nos campos do Direito, da Psicologia e da Antropologia.

  17. Licitações Diferenciadas para Microempresas e Empresas de Pequeno Porte – O Advendo da Lei Nº 13.706/2011 - Rio Grande do Sul

    Directory of Open Access Journals (Sweden)

    Clayton Rebello da Silva

    2011-12-01

    Full Text Available Este trabalho tem o objetivo de auxiliar na análise e discussão acerca da Lei no 13.706, de 06 de abril de 2011. Trata-se de legislação que tem por escopo os preceitos constantes na Lei Complementar no 123/2006, o denominado Estatuto Geral da Micro e da Pequena Empresa, decorrentes da Constituição da República, artigos 170 e 179. A analise ira se deter aos ditames relativos ao tratamento diferenciado e simplificado para as microempresas e para as pequenas empresas nas licitações públicas, incluindo-se também as cooperativas, a elas equiparadas por lei, no âmbito da Administração Pública Estadual. Nesse desiderato, percorremos, paralelamente, o instrumento normativo federal, Decreto no 6.204/2007, que regulamentou, naquele ente, o tratamento exigido pelo Estatuto Geral. Não nos furtaremos em apontar eventuais incongruências na novel normativa, ate mesmo porque se avizinha a implementação da sua regulamentação no âmbito estadual, conforme prevê artigo da própria lei.

  18. Formation of Rh-Au core-shell nanoparticles on TiO.sub.2./sub.(110) surface studied by STM and LEIS

    Czech Academy of Sciences Publication Activity Database

    Óvari, L.; Berkó, A.; Balázs, N.; Majzik, Zsolt; Kiss, J.

    2010-01-01

    Roč. 26, č. 3 (2010), s. 2167-2175 ISSN 0743-7463 Institutional research plan: CEZ:AV0Z10100521 Keywords : surface diffusion of gold * STM * LEIS Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 4.269, year: 2010

  19. Mycobacterial UvrD1 is a Ku-dependent DNA helicase that plays a role in multiple DNA repair events, including double-strand break repair.

    Science.gov (United States)

    Sinha, Krishna Murari; Stephanou, Nicolas C; Gao, Feng; Glickman, Michael S; Shuman, Stewart

    2007-05-18

    Mycobacterium tuberculosis and other bacterial pathogens have a Ku-dependent nonhomologous end joining pathway of DNA double-strand break repair. Here we identify mycobacterial UvrD1 as a novel interaction partner for Ku in a genome-wide yeast two-hybrid screen. UvrD1 per se is a vigorous DNA-dependent ATPase but a feeble DNA helicase. Ku stimulates UvrD1 to catalyze ATP-dependent unwinding of 3'-tailed DNAs. UvrD1, Ku, and DNA form a stable ternary complex in the absence of ATP. The Ku binding determinants are located in the distinctive C-terminal segment of UvrD1. A second mycobacterial paralog, UvrD2, is a vigorous Ku-independent DNA helicase. Ablation of UvrD1 sensitizes Mycobacterium smegmatis to killing by ultraviolet and ionizing radiation and to a single chromosomal break generated by I-SceI endonuclease. The physical and functional interactions of bacterial Ku and UvrD1 highlight the potential for cross-talk between components of nonhomologous end joining and nucleotide excision repair pathways.

  20. Coexposure to benzo[a]pyrene plus UVA induced DNA double strand breaks: visualization of Ku assembly in the nucleus having DNA lesions

    International Nuclear Information System (INIS)

    Toyooka, Tatsushi; Ibuki, Yuko; Koike, Manabu; Ohashi, Norio; Takahashi, Sentaro; Goto, Rensuke

    2004-01-01

    Benzo[a]pyrene (BaP) is a ubiquitous environmental pollutant with potential carcinogenicity. It has been shown that BaP, upon UVA irradiation, synergistically induced oxidative DNA damage, but other DNA damage was not confirmed. In this study, we examined whether coexposure to BaP plus UVA induces double strand breaks (DSBs) using xrs-5 cells, deficient in the repair of DSBs (Ku80 mutant), and whether Ku translocates involving the formation of DSBs. BaP plus UVA had a significant cytotoxic effect on CHO-K1 cells and an even more drastic effect on Ku80-deficient, xrs-5 cells, suggesting that the DSBs were generated by coexposure to BaP plus UVA. The DSBs were repaired in CHO-K1 cells within 30 min, but not in xrs-5 cells, indicating the involvement of a non-homologous end joining, which needs Ku proteins. Furthermore, we succeeded in visualizing that Ku80 rapidly assembled to the exposed region, in which DSBs might be generated, and clarified that the presence of both Ku70 and Ku80 was important for their accumulation

  1. Mre11 and Blm-Dependent Formation of ALT-Like Telomeres in Ku-Deficient Ustilago maydis.

    Directory of Open Access Journals (Sweden)

    Eun Young Yu

    2015-10-01

    Full Text Available A subset of human cancer cells uses a specialized, aberrant recombination pathway known as ALT to maintain telomeres, which in these cells are characterized by complex aberrations including length heterogeneity, high levels of unpaired C-strand, and accumulation of extra-chromosomal telomere repeats (ECTR. These phenotypes have not been recapitulated in any standard budding or fission yeast mutant. We found that eliminating Ku70 or Ku80 in the yeast-like fungus Ustilago maydis results initially in all the characteristic telomere aberrations of ALT cancer cells, including C-circles, a highly specific marker of ALT. Subsequently the ku mutants experience permanent G2 cell cycle arrest, accompanied by loss of telomere repeats from chromosome ends and even more drastic accumulation of very short ECTRs (vsECTRs. The deletion of atr1 or chk1 rescued the lethality of the ku mutant, and "trapped" the telomere aberrations in the early ALT-like stage. Telomere abnormalities are telomerase-independent, but dramatically suppressed by deletion of mre11 or blm, suggesting major roles for these factors in the induction of the ALT pathway. In contrast, removal of other DNA damage response and repair factors such as Rad51 has disparate effects on the ALT phenotypes, suggesting that these factors process ALT intermediates or products. Notably, the antagonism of Ku and Mre11 in the induction of ALT is reminiscent of their roles in DSB resection, in which Blm is also known to play a key role. We suggest that an aberrant resection reaction may constitute an early trigger for ALT telomeres, and that the outcomes of ALT are distinct from DSB because of the unique telomere nucleoprotein structure.

  2. Prontuário do paciente: a questão do sigilo e a lei de acesso à informação

    Directory of Open Access Journals (Sweden)

    Izângela Maria Sansoni Tonello

    2013-08-01

    Full Text Available Introdução: O presente artigo aborda a questão da confidencialidade, do sigilo das informações no prontuário do paciente. Nessa perspectiva, buscou-se demonstrar a importância dessas informações para diferentes finalidades profissionais, sem, no entanto alhear-se de seu aspecto privado. Por outro lado, analisou-se a Lei de Acesso à Informação, relacionando-a ao prontuário do paciente, que dispõe a respeito dos procedimentos a serem observados, estabelece limites, garante o acesso ao direito à informação e restringe o acesso aos documentos sigilosos referentes à honra e a imagem das pessoas.Objetivo: Analisar o caráter sigiloso e confidencial das informações do prontuário do paciente, ao cotejá-lo com a Lei de Acesso à Informação – Lei Nº 12.127 – de 18 de novembro de 2011.Metodologia: Realizou-se uma pesquisa bibliográfica em livros, artigos e sites relacionados.Resultados: Constatou-se que a Lei de Acesso à Informação e as resoluções do Conselho Federal de Medicina (CFM não se opõem e nem são excludentes, ou seja, ambas especificam a importância do sigilo em relação às informações pessoais.Conclusões: É possível afirmar que a referida Lei mantém as prescrições ditadas pelo CFM no quesito elaboração e disponibilização do prontuário do paciente, seguindo a mesma linha de raciocínio e de conduta.

  3. Formação Continuada e suas implicações: entre a lei e o trabalho docente

    OpenAIRE

    Magalhães, Lígia Karam Corrêa de; Azevedo, Leny Cristina Soares Souza

    2015-01-01

    Este artigo discute questões relativas à formação de professores, com ênfase na formação continuada, a partir da análise das Metas 15 e 16 do Plano Nacional de Educação - PNE 2014-2024, anexo à Lei 13005/14, evidenciando a influência da LDB 9.394/96, das Diretrizes Curriculares Nacionais para a Formação de Professores da Educação Básica, em nível superior, curso de licenciatura, de graduação plena e da Rede Nacional de Formação Continuada de Professores. Nossa análise está ancorada no pressup...

  4. ADOLESCÊNCIA E LAÇO SOCIAL CONTEMPORÂNEO: ENTRE O GOZO E A LEI

    Directory of Open Access Journals (Sweden)

    Altair José dos Santos

    2013-02-01

    Full Text Available A puberdade é constituída por uma realidade objetiva, por um corpo em transformação. Trata-se de um corpo estranho a exigir subjetivação e reconhecimento do adolescente e dos adultos à sua volta. Se na puberdade é essa realidade objetiva que se estabelece, na adolescência há uma realidade subjetiva que pulsa e exige objetivação na estranheza do corpo púbere. De modo geral, o escopo nessa reflexão é discutir acerca da subjetividade do adolescente e seus modos de laço social. Pretende-se especificamente, refletir acerca das condutas adolescentes ligadas ao que o discurso social nomeia por conflito com a lei.

  5. Compreendendo um jovem em conflito com a lei e poeta: a questão ética

    OpenAIRE

    Chaves, Roberta Arueira; Rabinovich, Elaine Pedreira

    2010-01-01

    Esse estudo se baseia nos poemas por um adolescente em conflito com a lei, escritos durante e após o período de cumprimento da medida sócio-educativa devido a crime de homicídio, até o seu suicídio. O estudo relata o encontro com o jovem, tanto pessoalmente quanto através de seus poemas, cuja temática central é o amor e a solidão face ao des/encontro. O método descreve os passos na busca da compreensão de sua subjetividade. Esta compreensão foi realizada por meio das idéias de Lévinas, trazen...

  6. Negotiating Culture, Economics and Community Politics: The Practice of Lei Yue Mun Tourism in Postcolonial Hong Kong

    Directory of Open Access Journals (Sweden)

    Shun-Hing Chan

    2011-11-01

    Full Text Available This article is based on an on-going research project that examines how tourism is constructed in Hong Kong by using the specific tourist spot, Lei Yue Mun, as a case study. The article’s aim is to demonstrate how the local agents of a small, squatter-based community with a distinctive history and cultural traditions may, without making any claim to indigenousness or aboriginality, manage a local economy and engage in cultural negotiation at the metropolitan, national and global levels. Their economic practices lead the authors to enquire whether preservationism or invoking historical traditions from the margins is the most significant form or strategy of cultural tourism.

  7. Oito anos de Lei Maria da Penha.: Entre avanços, obstáculos e desafios

    OpenAIRE

    Pasinato, Wânia

    2015-01-01

    Em 2014 a Lei Maria da Penha completou oito anos. A cada ano, os eventos comemorativos de sua aprovação trazem a oportunidade de realizar balanços e reflexões sobre os avanços, obstáculos e desafios colocados à sua implementação e seus impactos sobre a universalização do acesso aos direitos e à justiça para as mulheres em situação de violência doméstica e familiar. Este artigo tem o propósito de contribuir com algumas reflexões sobre a importância do atendimento em rede para alcançar resultad...

  8. Centros de educação e reabilitação de agressores na lei Maria da Penha

    OpenAIRE

    Elias, Miriam Luciana Freitas

    2014-01-01

    A dissertação aborda a importância de implementação das políticas públicas previstas na Lei Maria da Penha, principalmente dos Centros de Educação e Reabilitação de Agressores, como forma de respeito ao princípio da dignidade da pessoa humana e de propor uma alternativa eficaz para auxiliar a coibir a violência doméstica e familiar contra a mulher. Justifica-se essa alternativa pela natureza da violência de gênero, que sofre influência, dentre outras causas, da cultura patriarcal ainda presen...

  9. Leituras de Kafka: Escólios sobre a burocracia e o exercício da lei

    Directory of Open Access Journals (Sweden)

    Bruno Barbosa dos Santos

    2017-12-01

    Full Text Available Este ensaio tem como objetivo apresentar algumas considerações acerca da burocracia e do direito na obra de Franz Kafka. As breves notas que dão corpo ao texto buscam salientar conceitos fundamentais da literatura kafkiana para fazer deles um novo uso. Deste modo, distanciando-se da exegese “judaico-realística” de Max Brod, o texto recorrerá à fortuna crítica de autores como Walter Benjamin, Günther Anders e Giorgio Agamben para realizar outra leitura das categorias teológicas presentes em Kafka. Com isso, as notas a seguir procuram avaliar as estratégias investidas pelo prosador tcheco contra os mecanismos da lei.

  10. A technical writing programme implemented in a first-year engineering course at KU Leuven

    Science.gov (United States)

    Heylen, Christel; Vander Sloten, Jos

    2013-12-01

    Technical communication and technical writing are important skills for the daily work-life of every engineer. In the first-year engineering programme at KU Leuven, a technical writing programme is implemented within the project-based course 'Problem Solving and Engineering Design'. This paper describes a case study for implementing a writing programme based on active learning methods and situated learning in large classes. The programme consists of subsequent cycles of instructions, learning by doing and reflection on received feedback. In addition, a peer-review assignment, together with an interactive lecture using clicking devices, is incorporated within the assignments of the second semester. A checklist of desired writing abilities makes it easier to grade the large number of papers. Furthermore, this ensures that all staff involved in the evaluation process uses the same criteria to grade and for providing feedback.

  11. Low-loss negative index metamaterials for X, Ku, and K microwave bands

    Directory of Open Access Journals (Sweden)

    David A. Lee

    2015-04-01

    Full Text Available Low-loss, negative-index of refraction metamaterials were designed and tested for X, Ku, and K microwave frequency bands. An S-shaped, split-ring resonator was used as a unit cell to design homogeneous slabs of negative-index metamaterials. Then, the slabs of metamaterials were cut unto prisms to measure experimentally the negative index of refraction of a plane electromagnetic wave. Theoretical simulations using High-Frequency Structural Simulator, a finite element equation solver, were in good agreement with experimental measurements. The negative index of refraction was retrieved from the angle- and frequency-dependence of the transmitted intensity of the microwave beam through the metamaterial prism and compared well to simulations; in addition, near-field electromagnetic intensity mapping was conducted with an infrared camera, and there was also a good match with the simulations for expected frequency ranges for the negative index of refraction.

  12. Wideband Array for C, X, and Ku-Band Applications with 5.3:1 Bandwidth

    Science.gov (United States)

    Novak, Markus H.; Volakis, John L.; Miranda, Felix A.

    2015-01-01

    Planar arrays that exploit strong intentional coupling between elements have allowed for very wide bandwidths in low-profile configurations. However, such designs also require complex impedance matching networks that must also be very compact. For many space applications, typically occurring at C-, X-, Ku-, and most recently at Ka-band, such designs require specialized and expensive fabrication techniques. To address this issue, a novel ultra-wideband array is presented, using a simplified feed network to reduce fabrication cost. The array operates from 3.5-18.5 GHz with VSWR less than 2.4 at broadside, and is of very low profile, having a total height of lambda/10 at the lowest frequency of operation. Validation is provided using a 64-element prototype array, fabricated using common Printed Circuit Board (PCB) technology. The low size, weight, and cost of this array make it attractive for space-borne applications.

  13. STS-79 Ku-band antenna, ODS and Spacehab module at PCR

    Science.gov (United States)

    1996-01-01

    The orbiter Ku-band antenna looms large in this view of the Space Shuttle Atlantis' payload bay. Visible just past the antenna system -- stowed on the starboard side of the payload bay wall -- is the Orbiter Docking System (ODS), and connected to the ODS via a tunnel is the Spacehab Double Module in the aft area of the payload bay. This photograph was taken from the starboard wing platform on the fifth level of the Payload Changeout Room (PCR) at Launch Pad 39A. Work is under way in the PCR to close Atlantis' payload bay doors for flight. Atlantis currently is being targeted for liftoff on Mission STS-79, the fourth docking of the U.S. Shuttle to the Russian Space Station Mir, around September 12.

  14. A wideband superconducting filter at Ku-band based on interdigital coupling

    Science.gov (United States)

    Jiang, Ying; Wei, Bin; Cao, Bisong; Li, Qirong; Guo, Xubo; Jiang, Linan; Song, Xiaoke; Wang, Xiang

    2018-04-01

    In this paper, an interdigital-type resonator with strong electric coupling is proposed for the wideband high-frequency (>10 GHz) filter design. The proposed microstrip resonator consists of an H-shaped main line part with its both ends installed with interdigital finger parts. Strong electric coupling is achieved between adjacent resonators. A six-pole high-temperature superconducting filter at Ku-band using this resonator is designed and fabricated. The filter has a center frequency of 15.11 GHz with a fractional bandwidth of 30%. The insertion loss of the passband is less than 0.3 dB, and the return loss is greater than 14 dB without any tuning.

  15. Alte und neue Problemaspekte der Figur. Zu einem medienübergreifenden Versuch einer Begriffsbestimmung der Figur [Jens Eder / Fotis Jannidis / Ralf Schneider (Hg.: Characters in Fic­tional Worlds. Understanding Imaginary Beings in Literature, Film, and Other Media. Berlin 2010

    Directory of Open Access Journals (Sweden)

    Carmen Lăcan

    2012-12-01

    Full Text Available Rezension zu / Review of:Jens Eder / Fotis Jannidis / Ralf Schneider (Hg.: Characters in Fic­tional Worlds. Understanding Imaginary Beings in Literature, Film, and Other Media. Berlin 2010

  16. The pretreatment of corn stover with Gloeophyllum trabeum KU-41 for enzymatic hydrolysis

    Directory of Open Access Journals (Sweden)

    Gao Ziqing

    2012-05-01

    Full Text Available Abstract Background Pretreatment is an essential step in the enzymatic hydrolysis of biomass for bio-ethanol production. The dominant concern in this step is how to decrease the high cost of pretreatment while achieving a high sugar yield. Fungal pretreatment of biomass was previously reported to be effective, with the advantage of having a low energy requirement and requiring no application of additional chemicals. In this work, Gloeophyllum trabeum KU-41 was chosen for corn stover pretreatment through screening with 40 strains of wood-rot fungi. The objective of the current work is to find out which characteristics of corn stover pretreated with G. trabeum KU-41 determine the pretreatment method to be successful and worthwhile to apply. This will be done by determining the lignin content, structural carbohydrate, cellulose crystallinity, initial adsorption capacity of cellulase and specific surface area of pretreated corn stover. Results The content of xylan in pretreated corn stover was decreased by 43% in comparison to the untreated corn stover. The initial cellulase adsorption capacity and the specific surface area of corn stover pretreated with G. trabeum were increased by 7.0- and 2.5-fold, respectively. Also there was little increase in the cellulose crystallinity of pretreated corn stover. Conclusion G. trabeum has an efficient degradation system, and the results indicated that the conversion of cellulose to glucose increases as the accessibility of cellulose increases due to the partial removal of xylan and the structure breakage of the cell wall. This pretreatment method can be further explored as an alternative to the thermochemical pretreatment method.

  17. Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017); Venice (Italy); October 31-November 4, 2017; Session "Neonatal Fetal Nutrition and Metabolism"

    OpenAIRE

    --- Various Authors

    2017-01-01

    Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017); Venice (Italy); October 31-November 4, 201758th ESPR Annual Meeting, 7th International Congress of UENPS, 3rd International Congress of EFCNIORGANIZING INSTITUTIONSEuropean Society for Paediatric Research (ESPR), European Society for Neonatology (ESN), Union of European Neonatal & Perinatal Societies (UENPS), European Foundation for the Care of Newborn Infants (EFCNI)ORGANIZING COMMITTEELuc Zimmer...

  18. Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017); Venice (Italy); October 31-November 4, 2017; Session "Neonatal Pulmonology, Neonatal Respiratory Support, Resuscitation"

    OpenAIRE

    --- Various Authors

    2017-01-01

    Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017); Venice (Italy); October 31-November 4, 201758th ESPR Annual Meeting, 7th International Congress of UENPS, 3rd International Congress of EFCNIORGANIZING INSTITUTIONSEuropean Society for Paediatric Research (ESPR), European Society for Neonatology (ESN), Union of European Neonatal & Perinatal Societies (UENPS), European Foundation for the Care of Newborn Infants (EFCNI)ORGANIZING COMMITTEELuc Zimmermann...

  19. Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017); Venice (Italy); October 31-November 4, 2017; Session "Neurology and Follow-up"

    OpenAIRE

    --- Various Authors

    2017-01-01

    Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017); Venice (Italy); October 31-November 4, 201758th ESPR Annual Meeting, 7th International Congress of UENPS, 3rd International Congress of EFCNIORGANIZING INSTITUTIONSEuropean Society for Paediatric Research (ESPR), European Society for Neonatology (ESN), Union of European Neonatal & Perinatal Societies (UENPS), European Foundation for the Care of Newborn Infants (EFCNI)ORGANIZING COMMITTEELuc Zimmer...

  20. Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017); Venice (Italy); October 31-November 4, 2017; Session "Quality Improvement, Parents Centered Care"

    OpenAIRE

    --- Various Authors

    2017-01-01

    Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017); Venice (Italy); October 31-November 4, 201758th ESPR Annual Meeting, 7th International Congress of UENPS, 3rd International Congress of EFCNIORGANIZING INSTITUTIONSEuropean Society for Paediatric Research (ESPR), European Society for Neonatology (ESN), Union of European Neonatal & Perinatal Societies (UENPS), European Foundation for the Care of Newborn Infants (EFCNI)ORGANIZING COMMITTEELuc Zi...

  1. Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017); Venice (Italy); October 31-November 4, 2017; Session "Neonatal Infectious Diseases/Immunology"

    OpenAIRE

    --- Various Authors

    2017-01-01

    Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017); Venice (Italy); October 31-November 4, 201758th ESPR Annual Meeting, 7th International Congress of UENPS, 3rd International Congress of EFCNIORGANIZING INSTITUTIONSEuropean Society for Paediatric Research (ESPR), European Society for Neonatology (ESN), Union of European Neonatal & Perinatal Societies (UENPS), European Foundation for the Care of Newborn Infants (EFCNI)ORGANIZING COMMITTEELuc Zimmer...

  2. ANÁLISE DOS RELATÓRIOS DA EXECUÇÃO ORÇAMENTÁRIA E DA GESTÃO FISCAL NO CONTEXTO DA LEI DE RESPONSABILIDADE FISCAL

    OpenAIRE

    Maria Cristina de Campos Zirbes; Jucelaine Bitarello; Tarcísio Staudt

    2009-01-01

    A Lei de Responsabilidade Fiscal, Lei Complementar 101/2000, tem como pressuposto o gerenciamento dos gastos públicos visando à transparência, ao controle e à fiscalização da gestão pública. A problemática está em como a Lei de Responsabilidade Fiscal tem contribuído para o gerenciamento dos gastos públicos e a transparência da gestão governamental? Destaca-se que a LRF pode ser considerada nova, encontrando-se poucos estudos que exploram os efeitos sobre os orçamentos municipais. Nesse conte...

  3. A situação da lei na ótica da subjetividade: um estudo no vivido das crianças e jovens na Casa-Lar, Bela Vista - Vitória ES

    OpenAIRE

    Oliveira, Arlete Correa de

    2011-01-01

    Este trabalho questiona a lei, sob a ótica da subjetividade, no universo de crianças e jovens abrigados na Casa-Lar Bela Vista, Vitória, Espírito Santo. Sua temática central é a lei da proibição do incesto (EEP) e os complexos familiares (Lacan) cujos pressupostos teóricos orientam esta pesquisa e permitem explicitar a presença dessa lei na subjetividade humana e no laço social. Dentro desse questionamento, surge a importância da interface entre a assistência social e a explici...

  4. Jens Esmark's Christiania (Oslo) meteorological observations 1816-1838: the first long-term continuous temperature record from the Norwegian capital homogenized and analysed

    Science.gov (United States)

    Hestmark, Geir; Nordli, Øyvind

    2016-11-01

    In 2010 we rediscovered the complete set of meteorological observation protocols made by Jens Esmark (1762-1839) during his years of residence in the Norwegian capital of Oslo (then Christiania). From 1 January 1816 to 25 January 1839, Esmark at his house in Øvre Voldgate in the morning, early afternoon and late evening recorded air temperature with state-of-the-art thermometers. He also noted air pressure, cloud cover, precipitation and wind directions, and experimented with rain gauges and hygrometers. From 1818 to the end of 1838 he twice a month provided weather tables to the official newspaper Den Norske Rigstidende, and thus acquired a semi-official status as the first Norwegian state meteorologist. This paper evaluates the quality of Esmark's temperature observations and presents new metadata, new homogenization and analysis of monthly means. Three significant shifts in the measurement series were detected, and suitable corrections are proposed. The air temperature in Oslo during this period is shown to exhibit a slow rise from 1816 towards 1825, followed by a slighter fall again towards 1838.

  5. Enterocin X, a Novel Two-Peptide Bacteriocin from Enterococcus faecium KU-B5, Has an Antibacterial Spectrum Entirely Different from Those of Its Component Peptides▿

    Science.gov (United States)

    Hu, Chih-Bo; Malaphan, Wanna; Zendo, Takeshi; Nakayama, Jiro; Sonomoto, Kenji

    2010-01-01

    Enterocin X, composed of two antibacterial peptides (Xα and Xβ), is a novel class IIb bacteriocin from Enterococcus faecium KU-B5. When combined, Xα and Xβ display variably enhanced or reduced antibacterial activity toward a panel of indicators compared to each peptide individually. In E. faecium strains that produce enterocins A and B, such as KU-B5, only one additional bacteriocin had previously been known. PMID:20418437

  6. Enterocin X, a novel two-peptide bacteriocin from Enterococcus faecium KU-B5, has an antibacterial spectrum entirely different from those of its component peptides.

    Science.gov (United States)

    Hu, Chih-Bo; Malaphan, Wanna; Zendo, Takeshi; Nakayama, Jiro; Sonomoto, Kenji

    2010-07-01

    Enterocin X, composed of two antibacterial peptides (Xalpha and Xbeta), is a novel class IIb bacteriocin from Enterococcus faecium KU-B5. When combined, Xalpha and Xbeta display variably enhanced or reduced antibacterial activity toward a panel of indicators compared to each peptide individually. In E. faecium strains that produce enterocins A and B, such as KU-B5, only one additional bacteriocin had previously been known.

  7. DNA requirements for interaction of the C-terminal region of Ku80 with the DNA-dependent protein kinase catalytic subunit (DNA-PKcs).

    Science.gov (United States)

    Radhakrishnan, Sarvan Kumar; Lees-Miller, Susan P

    2017-09-01

    Non-homologous end joining (NHEJ) is the major pathway for the repair of ionizing radiation induced DNA double strand breaks (DSBs) in human cells. Critical to NHEJ is the DNA-dependent interaction of the Ku70/80 heterodimer with the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) to form the DNA-PK holoenzyme. However, precisely how Ku recruits DNA-PKcs to DSBs ends to enhance its kinase activity has remained enigmatic, with contradictory findings reported in the literature. Here we address the role of the Ku80 C-terminal region (CTR) in the DNA-dependent interaction of Ku70/80 with DNA-PKcs using purified components and defined DNA structures. Our results show that the Ku80 CTR is required for interaction with DNA-PKcs on short segments of blunt ended 25bp dsDNA or 25bp dsDNA with a 15-base poly dA single stranded (ss) DNA extension, but this requirement is less stringent on longer dsDNA molecules (35bp blunt ended dsDNA) or 25bp duplex DNA with either a 15-base poly dT or poly dC ssDNA extension. Moreover, the DNA-PKcs-Ku complex preferentially forms on 25 bp DNA with a poly-pyrimidine ssDNA extension.Our work clarifies the role of the Ku80 CTR and dsDNA ends on the interaction of DNA-PKcs with Ku and provides key information to guide assembly and biology of NHEJ complexes. Copyright © 2017 Elsevier B.V. All rights reserved.

  8. Autobiografie v českém středověku

    Directory of Open Access Journals (Sweden)

    Marie Bláhová

    2017-01-01

    Full Text Available This is an overview of the first instances of the realization of personality in Bohemia, which appear in historical literature from the 12th century and lead to the essay on medieval autobiographies. Although in the Middle Ages autobiographies were rare both in Bohemia as well as in other countries within the Latin cultural circle we are able to identify three significant autobiographies from different social environments, of different literary type and with different functions within two centuries of the late medieval period: First, the autobiography of Charles IV. This was the autobiography of a monarch written as a reflection of a Prince aimed at the author’s heirs to provide an image of the upbringing and behaviour of an exemplary monarch. The second text of this type is the autobiographical letter of former Archbishop of Prague, Jan of Jenštejn, in which the author used his own destiny to explain his political failure. At the very end of the medieval period, Christoph of Tyn, a minor nobleman who gained social success in the Emperor’s army and in diplomatic services, wrote an autobiography, where he wanted to show his descendants and future heirs how to increase the family estates legally, through honest endeavour so that they would not be ashamed of their heritage and doubt its respectable provenace. All of the authors mentioned had their own particular reasons for writing an autobiography. Naturally, all of these autobiographies are subjective, the narration is tailored to its purpose – political goals, justification of one’s failure, “substantiation” for and expression of pride in legally gained property.

  9. EPR study of gamma and neutron irradiation effects on KU1, KS-4V and Infrasil 301 silica glasses

    International Nuclear Information System (INIS)

    Lagomacini, Juan C.; Bravo, David; Leon, Monica; Martin, Piedad; Ibarra, Angel; Martin, Agustin; Lopez, Fernando J.

    2011-01-01

    Electron paramagnetic resonance (EPR) studies have been carried out on KU1 and KS-4V high purity quartz glasses and commercial silica Infrasil 301, irradiated with gamma rays up to a dose of 11.6 MGy and neutron fluences of 10 21 and 10 22 n/m 2 . Gamma irradiations produce a much higher concentration of defect centres (mainly E', POR and NBOHC) for KU1 and I301 than for KS-4V silica. In contrast, neutron irradiation at the highest fluence produces similar concentrations in all silica types. These results agree to a good extent with those obtained in previous optical absorption measurements. Moreover, oxygen-related centres (POR and NBOHC) have been well characterized by means of electron paramagnetic resonance.

  10. EPR study of gamma and neutron irradiation effects on KU1, KS-4V and Infrasil 301 silica glasses

    Energy Technology Data Exchange (ETDEWEB)

    Lagomacini, Juan C., E-mail: jc.lagomacini@uam.es [Dept. Fisica de Materiales, Universidad Autonoma de Madrid, E-28049 Madrid (Spain); Bravo, David [Dept. Fisica de Materiales, Universidad Autonoma de Madrid, E-28049 Madrid (Spain); Leon, Monica; Martin, Piedad; Ibarra, Angel [Materiales para Fusion, CIEMAT, Avda. Complutense 22, E-28040 Madrid (Spain); Martin, Agustin [Dept. Fisica e Instalaciones, ETS Arquitectura UPM, E-28040 Madrid (Spain); Lopez, Fernando J. [Dept. Fisica de Materiales, Universidad Autonoma de Madrid, E-28049 Madrid (Spain)

    2011-10-01

    Electron paramagnetic resonance (EPR) studies have been carried out on KU1 and KS-4V high purity quartz glasses and commercial silica Infrasil 301, irradiated with gamma rays up to a dose of 11.6 MGy and neutron fluences of 10{sup 21} and 10{sup 22} n/m{sup 2}. Gamma irradiations produce a much higher concentration of defect centres (mainly E', POR and NBOHC) for KU1 and I301 than for KS-4V silica. In contrast, neutron irradiation at the highest fluence produces similar concentrations in all silica types. These results agree to a good extent with those obtained in previous optical absorption measurements. Moreover, oxygen-related centres (POR and NBOHC) have been well characterized by means of electron paramagnetic resonance.

  11. Experimental demonstration of a Ku-band radial-line relativistic klystron oscillator based on transition radiation

    Science.gov (United States)

    Dang, Fangchao; Zhang, Xiaoping; Zhang, Jun; Ju, Jinchuan; Zhong, Huihuang

    2017-03-01

    We report on a radial-line relativistic klystron oscillator (RL-RKO), which is physically designed to generate gigawatt-level high power microwaves (HPMs) at Ku-band. The 3π/4 mode of a four-gap buncher is selected to highly modulate the radially propagating intense relativistic electron beam (IREB). A three-gap extractor operating at the π mode is employed to extract the radio-frequency energy efficiently. The Ku-band RL-RKO is investigated experimentally on an intense-current electron beam accelerator. The radially propagating IREB is well focused with an axial-width of 2 mm by a radial magnetic field of 0.4 T. Microwaves with a frequency of 14.86 GHz and a power of 1.5 GW are generated, corresponding to an efficiency of 24%, which indicates a significant advance for the research of radial-line HPM sources.

  12. Suppression of the asymmetric competition mode in the relativistic Ku-band coaxial transit-time oscillator

    Energy Technology Data Exchange (ETDEWEB)

    Ling, Junpu; He, Juntao; Zhang, Jiande; Jiang, Tao; Wang, Lei [College of Optoelectronic Science and Engineering, National University of Defense Technology, Changsha 410073 (China)

    2014-10-15

    A relativistic Ku-band coaxial transit-time oscillator has been proposed in our previous work. In the experiments, we find that the asymmetric competition mode in the device limits the microwave power with the increase of the input electric power. For solving such a problem, the methods for analysis and suppression of the asymmetric competition mode in the device are investigated theoretically and experimentally. It is shown that the structure and the material of the collector, the concentricity, and the electron emission uniformity play an important part in the suppression of the asymmetric competition mode in the relativistic Ku-band transit-time oscillator. In the subsequent experiments, the asymmetric mode was suppressed effectively. At a low guiding magnetic field of 0.7 T, a microwave pulse with power of 1 GW, frequency of 14.3 GHz close to the simulation one, and efficiency of 20% was generated.

  13. Estado e Política Social: considerações sobre a política de atendimento socioeducativo ao adolescente em conflito com a Lei no Brasil a partir da década de 1990

    Directory of Open Access Journals (Sweden)

    Vanessa Gabrielle Woicolesco

    2017-12-01

    Full Text Available Neste artigo, analisa-se a Política de Atendimento Socioeducativo ao adolescente em conflito com a lei, concebida enquanto componente da Política Social que, implementada pelo Estado, contribui para as suas ações de direção e controle social e, ao mesmo tempo, é parte constituinte da repartição da riqueza socialmente produzida. Nesse sentido, busca-se abordar a Política voltada ao adolescente em conflito com a lei, no Brasil, a partir dos seguintes ordenamentos jurídicos e institucionais: Lei nº 8.069/90, Estatuto da Criança e do Adolescente – ECA; e Lei nº 12.594/12, Sistema Nacional de Atendimento Socioeducativo – SINASE.

  14. Oxygen Isotope Records in Modern Oyster Shells from Chi Ku, Tainan and Their Implication of Seasonality

    Science.gov (United States)

    Chen, Y. C.; Mii, H. S.; Li, K. T.

    2015-12-01

    To exam whether oxygen isotope records of Crassostrea gigasoysters can be used as proxies of environment, 133 cultivated oysters and 21 water samples were collected from Chi Ku area, Tainan City, southern Taiwan in December of 2012, and from March, 2013 to July, 2014. Instrumental air and water temperatures and precipitation records were obtained from a nearest Central Weather Bureau (CWB) station roughly 16 km north of Chi Ku. The oxygen and carbon isotope values of the ligamental area of the modern oyster shells are from -6.92‰ to -0.08‰ (-3.05 ± 1.17‰, N = 2280; 1σ; VPDB) and from -5.57‰ to 0.63‰ (-1.88 ± 0.81‰), respectively. Oxygen isotope values of the water samples are mainly between -0.28‰ and 0.74‰ (0.18 ± 0.29‰, N = 20; 1σ; VSMOW). However, water oxygen isotope value of -2.75‰ was observed for the water sample collected immediately after a typhoon heavy rainfall. Seasonal temperature fluctuation pattern of estimated oxygen isotope temperatures from modern shells is similar to that of CWB instrumental records. However, the oxygen isotope temperatures are respectively about 3 °C and 10°C higher than those of instrumental records for winter and summer. Higher estimated oxygen isotope temperatures are most likely caused by underestimated fraction of freshwater. We analyzed 5 archaeological oyster shells of Siraya culture (500~250B.P.) collected from Wu Chien Tuso North (WCTN) archaeological site of Tainan branch of Southern Taiwan Science Park to infer the harvest season of mollusks. Oxygen isotope values of the ligamental area of the archaeological oyster shells are between -5.98‰ and -1.26‰ (-3.34 ± 1.37‰, N = 60; 1σ), and carbon isotope values are between -3.21‰ and 0.60‰ (-2.04‰ ± 0.55‰). The oxygen isotope records of archaeological oyster shells also showed clear seasonality. Most of the oysters were collected in autumn and winter. Oxygen isotope values of archaeological oyster shells was 1‰ greater than that

  15. Memória vs esquecimento: análise do processo de formulação da Lei de Acesso à Informação

    Directory of Open Access Journals (Sweden)

    Alessandra Guimarães Soares

    2017-08-01

    Full Text Available O objetivo deste trabalho é analisar o processo político que levou as mudanças na Lei de Acesso à Informação Pública que permitiram a abertura dos arquivos do período de exceção e, consequentemente, serviram para viabilizar os trabalhos da Comissão Nacional da Verdade (CNV. A análise, realizada a partir do binômio memória vs esquecimento, traz os embates travados sobre esse tema no Congresso Nacional pós-Constituição de 1988 até o ano de 2011, momento de criação da CNV e da edição da última alteração da Lei de Acesso à Informação. O referencial teórico metodológico empregado foi o do advocacy coalition framework.

  16. POLÍTICAS PÚBLICAS E ADOLESCENTES EM CONFLITO COM A LEI: revisão sistemática da literatura nacional

    OpenAIRE

    Lisiane Ligia Mella; Jéssica Limberger; Ilana Andretta

    2016-01-01

    Políticas públicas voltadas ao adolescente em conflito com a lei têm sido amplamente destacadas ao longo da história brasileira, principalmente após o processo de redemocratização do país, que culminou na promulgação da Constituição Federal de 1988 e o posterior Estatuto da Criança e do Adolescente (ECA) em 1990. A presente revisão bibliográfica objetiva descrever estudos brasileiros de 2005 a 2015 acerca das políticas públicas dos adolescentes em conflito com a lei, analisando se tais estudo...

  17. A Lei Maria da Penha sob a perspectiva da ética da vingança / Maria da Penha law unde the ethics of revenge approach

    OpenAIRE

    Nunes, Thaísa Silva de Oliveira; Faculdade de Direito de Vitória

    2011-01-01

    RESUMO: Analisa-se a lei 11.340/2006, conhecida como Lei Maria da Penha, sob a perspectiva da ética da vingança, considerando-se a situação de seu uso de forma equivocada. Nesse sentido, argui-se que o judiciário deve tomar um cuidado maior ao julgar casos de violência doméstica. Aborda-se também a possibilidade de uma mulher abandonada ou ultrajada pelo seu companheiro reagir de forma a resgatar a confiança em si, ao invés de se utilizar da prática da vingança permitida pelos mecanismos jurí...

  18. Intervenção do Estado na economia através da lei anticorrupção 12.846/2013

    Directory of Open Access Journals (Sweden)

    Natália Martins de Abreu

    2016-04-01

    Full Text Available O presente trabalho trata-se de resumo sobre o livro Lei Anticorrupção: origens, comentários e análise da legislação correlata e traz em seu texto considerações dos autores a respeito das inovações, críticas e benefícios trazidos por este importante instrumento normativo para o momento que o Brasil atravessa com a crise política e empresarial advinda do instituto da corrupçào. Menciona-se aidna algumas peculiaridades da lei bem como mecanismos para o combate da corrupção realizada pelas empresas.

  19. [Professor Wacław Kuśnierczyk (1908-1997)--Pro Memoria in the century of birthday].

    Science.gov (United States)

    Brozek, Krzysztof; Kozakiewicz, Jacek; Kierzek, Andrzej

    2009-01-01

    Wacław Kuśnierczyk was born in 1908 in Sniatyń. He received the degree in medicine at Jan Kazimierz University in Lwów in 1932. He did his PhD degree under Professor Zaleski supervision in 1938 at Jan Kazimierz University. At that time he concentrated his scientific activity on research on tuberculosis. In 1953 he obtained the title of second degree specialist in ear, nose and throat diseases. He became a chief of Otolaryngology at Urban Hospital No 4 in Katowice in 1960. Since then this eminent physician was working on tumours located in upper respiratory tract and the possibility of its endoscopic diagnosis at Silesian Academy of Medicine in Katowice. As one of the first he pointed out the negative influence of smoking cigarettes on cancer of larynx. It was Wacław Kuśnierczyk who implemented new priorities for integrated programs in patient care, research, education and cancer prevention. He has published widely in peer reviewed journals and has edited or contributed to many books. He has given many major lectures and is the recipient of numerous prestigious awards for his scientific accomplishments. The achievement of Professor Kuśnierczyk were the valuable source of information for the physicians. In 1997, on the 31st of January he died in Katowice.

  20. PAXX Is an Accessory c-NHEJ Factor that Associates with Ku70 and Has Overlapping Functions with XLF

    Directory of Open Access Journals (Sweden)

    Satish K. Tadi

    2016-10-01

    Full Text Available In mammalian cells, classical non-homologous end joining (c-NHEJ is critical for DNA double-strand break repair induced by ionizing radiation and during V(DJ recombination in developing B and T lymphocytes. Recently, PAXX was identified as a c-NHEJ core component. We report here that PAXX-deficient cells exhibit a cellular phenotype uncharacteristic of a deficiency in c-NHEJ core components. PAXX-deficient cells display normal sensitivity to radiomimetic drugs, are proficient in transient V(DJ recombination assays, and do not shift toward higher micro-homology usage in plasmid repair assays. Although PAXX-deficient cells lack c-NHEJ phenotypes, PAXX forms a stable ternary complex with Ku bound to DNA. Formation of this complex involves an interaction with Ku70 and requires a bare DNA extension for stability. Moreover, the relatively weak Ku-dependent stimulation of LIG4/XRCC4 activity by PAXX is unmasked by XLF ablation. Thus, PAXX plays an accessory role during c-NHEJ that is largely overlapped by XLF’s function.

  1. A Lei de Acesso à Informação como instrumento de controle social: diagnóstico dos municípios do sul do Brasil à luz do artigo 8º da lei 12527/2011

    Directory of Open Access Journals (Sweden)

    Marcelo Medeiros da Rosa

    2016-01-01

    Full Text Available Este estudo objetiva identificar qual o percentual de municipios da região sul do Brasil divulgam as informações exigidas no art. 8° da Lei de Acesso à Informação em seus sítios eletrônicos. Em relação ao objetivo, esta pesquisa pode ser classificada como descritiva, de lógica dedutiva, abordagem qualitativa, enquadrada como bibliográfica e documental e realizada por meio de consultas aos sítios eletrônicos de 216 municípios. A partir dos dados coletados, conclui-se que, de modo geral, os municípios da região sul do Brasil, com população superior a 10 mil habitantes, atendem parcialmente aos requisitos apresentados no Art. 8 da LAI. Com esses resultados, espera-se que os cidadãos possam cobrar dos governantes a melhoria na qualidade das informações de interesse público divulgadas, exercendo assim o controle social e contribuindo para a melhoria da gestão pública e a inibição da corrupção. 

  2. A CPMI da Violência Contra a Mulher e a Implementação da Lei Maria Da Penha

    Directory of Open Access Journals (Sweden)

    Carmen Hein de Campos

    2015-05-01

    Full Text Available Este artigo analisa as conclusões da Comissão Parlamentar Mista de Inquérito da Violência contra a Mulher, criada pelo Congresso Nacional Brasileiro em 2012, no que tange à aplicação da Lei Maria da Penha. Após um ano e meio de trabalho, o relatório da CPMI apontou a fragilidade das políticas públicas de enfrentamento à violência contra mulheres e os obstáculos na implementação da Lei Maria da Penha, dentre os quais, destacam-se: a precariedade da rede de serviços e o reduzido número de juizados especializados em atendimento às mulheres em situação de violência doméstica e familiar; o descumprimento da decisão do Supremo Tribunal Federal que proíbe a aplicação da suspensão condicional do processo; a resistência de operadores/as do direito em entender a proposta da nova lei e romper com a lógica familista e o insuficiente orçamento para o desenvolvimento e a manutenção das políticas públicas de enfrentamento a essas situações de violência. A análise do relatório da CPMI permite concluir que os estados brasileiros investem muito pouco em políticas públicas específicas e que a implementação integral da Lei Maria da Penha depende de uma nova compreensão jurídica, da articulação entre os poderes públicos e de uma política orçamentária de gênero.

  3. EM NOME DA LEI: DIREITO, ESCRITURA E DESCONSTRUÇÃO IN THE NAME OF THE LAW: LAW, WRITING AND DECONSTRUCTIONES

    Directory of Open Access Journals (Sweden)

    DANIEL GOMES MACHADO

    2012-12-01

    Full Text Available Resumo: Na medida em que se impõe ao pensamento, a desconstrução pode ser vista como uma lei, a Lei mesma. A desconstrução do direito implica em situá-lo no contexto da escritura, para enxergar sua submissão à différance, ao jogo de remetimentos da linguagem. A lei da desconstrução atua na desconstrução da lei, revelando aporias e fragilidades da ordem jurídica, bem como dos conceitos tradicionais de direito natural e direitos humanos. A desconstrução do direito faz emergir a justiça como indecidibilidade, o dever de decidir pelo justo, mesmo quando não se pode afirmar pela presença da justiça. Direito, escritura e desconstrução convergem, enfim, na noção de uma hospitalidade sem restrições.Abstract: Since it is imposed to thinking, deconstruction can be seen as a law, the Law itself. Deconstruction of law is to put it in the context of writing, to notice its submission to the différance, to the play in the language. The law of deconstruction acts in the deconstruction of law, revealing paradoxes and fragilities of juridical order, as well as concepts of natural law and human rights. Finally, deconstruction of law brings with it justice as undecidability, such as the obligation to make fair decisions, even when it is not possible to state the presence of justice. Law, writing and deconstruction converge then to justice, understood as the hospitality.

  4. Adolescente em conflito com a lei no Brasil: da situação irregular à proteção integral.

    OpenAIRE

    Gustavo de Melo Silva

    2015-01-01

    Neste artigo buscar-se-á relatar um pouco sobre a história das legislações referentes ao adolescente em conflito com a lei no Brasil, de maneira a situar melhor a mudança de paradigma que ocorreu na passagem da doutrina jurídica da situação irregular para a vigente doutrina da proteção integral

  5. Adolescente em conflito com a lei no Brasil: da situação irregular à proteção integral.

    Directory of Open Access Journals (Sweden)

    Gustavo de Melo Silva

    2015-05-01

    Full Text Available Neste artigo buscar-se-á relatar um pouco sobre a história das legislações referentes ao adolescente em conflito com a lei no Brasil, de maneira a situar melhor a mudança de paradigma que ocorreu na passagem da doutrina jurídica da situação irregular para a vigente doutrina da proteção integral

  6. Vinte Anos da Convenção de Belém do Pará e a Lei Maria Da Penha

    Directory of Open Access Journals (Sweden)

    Lourdes Maria Bandeira

    2015-05-01

    Full Text Available Em 2014, completaram-se duas décadas da Convenção Interamericana para Prevenir, Punir e Erradicar a Violência Contra a Mulher (Convenção de Belém do Pará, que é a base original da Lei no 11.340 (Lei Maria da Penha e que continua a ser a referência para seu entendimento sociojurídico e a dimensionar sua eficácia. Nas comemorações destes 20 anos, vê-se maior precisão das compreensões e do desdobramento da Convenção, alcançados a partir das iniciativas tomadas pelos Estados signatários. Em um processo de retroalimentação, o refinamento de seus termos e princípios vem impactando legislações e medidas, adotados individualmente, dentro das soberanias nacionais. O presente artigo desenvolve uma reflexão sobre a Convenção e sua atual importância para o enfrentamento da violência contra as mulheres no Brasil, indicando perspectivas futuras ao escopo da Lei Maria da Penha.

  7. A EFICÁCIA DA APLICAÇÃO DA LEI DE CRIMES AMBIENTAIS PARA A PROTEÇÃO DO MEIO AMBIENTE NO LITORAL SUL DA BAHIA

    Directory of Open Access Journals (Sweden)

    Reinaldo Martins Lemos

    2013-12-01

    Full Text Available Este trabalho buscou avaliar a efetividade da aplicação da Lei de Crimes Ambientais e o andamento dos processos administrativos e judiciais no Litoral Sul da Bahia, como forma de proteção ambiental. Esta região é de grande importância ecológica, onde possui várias Unidades de Conservação, por isso, é uma parte importante no Corredor Central da Mata Atlântica – CCMA – Brasil. Foram analisados 136 autos de infrações ambientais emitidos pelo IBAMA em Ilhéus/BA, no ano de 2010, para avaliar a eficácia da aplicação da Lei de Crimes Ambientais e seu andamento, situação e duração nos processos administrativo, civil e penal. O presente estudo mostrou que há a necessidade de criar iniciativas para aperfeiçoar e responsabilizar os infratores para coibir ou diminuir os crimes ambientais no Litoral Sul da Bahia, com a localização e identificação dos crimes e seus responsáveis, bem como, uma maior agilidade nos processos administrativos, civis e penais, para punir os infratores e aumentar a eficácia, eficiência e efetividades dos órgãos ambientais e das Leis de Crimes Ambientais.  

  8. A Small Ku-Band Polarization Tracking Active Phased Array for Mobile Satellite Communications

    Directory of Open Access Journals (Sweden)

    Wei Shi

    2013-01-01

    Full Text Available A compact polarization tracking active phased array for Ku-band mobile satellite signal reception is presented. In contrast with conventional mechanically tracking antennas, the approach presented here meets the requirements of beam tracking and polarization tracking simultaneously without any servo components. The two-layer stacked square patch fed by two probes is used as antenna element. The impedance bandwidth of 16% for the element covers the operating frequency range from 12.25 GHz to 12.75 GHz. In the presence of mutual coupling, the dimensional parameters for each element of the small 7 × 7 array are optimized during beam scanning and polarization tracking. The compact polarization tracking modules based on the low-temperature cofired ceramic (LTCC system-in-package (SiP technology are proposed. A small active phased array prototype with the size of 120 mm (length × 120 mm (width × 55 mm (height is developed. The measured polarization tracking patterns of the prototype are given. The polarization tracking beam can be steered in the elevation up to 50°. The gain of no less than 16.0 dBi and the aperture efficiency of more than 50% are obtained. The measured and simulated polarization tracking patterns agreed well.

  9. Analysis and comparison model for measuring tropospheric scintillation intensity for Ku-band frequency in Malaysia

    Directory of Open Access Journals (Sweden)

    Mandeep JS

    2011-06-01

    Full Text Available This study has been based on understanding local propagation signal data distribution characteristics and identifying and predicting the overall impact of significant attenuating factors regarding the propagation path such as impaired propagation for a signal being transmitted. Predicting propagation impairment is important for accurate link budgeting, thereby leading to better communication network system designation. This study has thus used sample data for one year concerning beacon satellite operation in Malaysia from April 2008 to April 2009. Data concerning 12GHz frequency (Ku-band and 40° elevation angle was collected and analysed, obtaining average signal amplitude value, ÷ and also standard deviation ó which is normally measured in dB to obtain long-term scintillation intensity distribution. This analysis showed that scintillation intensity distribution followed Gaussian distribution for long-term data distribution. A prediction model was then selected based on the above; Karasawa,
    ITU-R, Van de Kamp and Otung models were compared to obtain the best prediction model performance for selected data regarding specific meteorological conditions. This study showed that the Karasawa model had the best performance for predicting scintillation intensity for the selected da ta.

  10. Extracted atmospheric impairments on earth-sky signal quality in tropical regions at Ku-band

    Science.gov (United States)

    Al-Saegh, Ali Mohammed; Sali, Aduwati; Mandeep, J. S.; Ismail, Alyani

    2013-11-01

    Atmospheric condition variations were shown to have a major effect on the earth sky signal quality at Ku band. Moreover, such variations increased in the tropical regions as compared to temperate areas due to their different weather parameters. With the increase of recent satellite communication technology applications throughout the tropical countries and lack of information regarding the atmospheric impairments analysis, simulation and mitigation techniques, there is an ever increasing need for extracting a unique and accurate performance of the signal quality effects during highly natural tropical weather impairments. This paper presents a new method developed for proper analysis with distinctive and highly realistic performance evaluation for signal quality during the atmospheric conditions variations in 14 tropical areas from the four continents analyzed based on actual measured parameters. The method implementation includes signal attenuation, carrier to noise ratio, symbol energy to noise ratio, and symbol error rate at different areas and different modulation schemes. Furthermore, for improvement in analysis in terms of covering more remarkable regions in tropics, the paper provides new measurements data with analysis for certain region in tropics used as a test bed and to add measurement data of such area to the world's data base for future researchers. The results show a significant investigation and performance observation in terms of weather impairments in tropical regions in general and each region in that area in particular regarding the signal attenuation and error rates accompanied for several transmission schemes.

  11. Design studies of the Ku-band, wide-band Gyro-TWT amplifier

    Science.gov (United States)

    Jung, Sang Wook; Lee, Han Seul; Jang, Kwong Ho; Choi, Jin Joo; Hong, Yong Jun; Shin, Jin Woo; So, Jun Ho; Won, Jong Hyo

    2014-02-01

    This paper reports a Ku-band, wide band Gyrotron-Traveling-wave-tube(Gyro-TWT) that is currently being developed at Kwangwoon University. The Gyro-TWT has a two stage linear tapered interaction circuit to obtain a wide operating bandwidth. The linearly-tapered interaction circuit and nonlinearly-tapered magnetic field gives the Gyro-TWT a wide operating bandwidth. The Gyro-TWT bandwidth is 23%. The 2d-Particle-in-cell(PIC) and MAGIC2d code simulation results are 17.3 dB and 24.34 kW, respectively for the maximum saturated output power. A double anode MIG was simulated with E-Gun code. The results were 0.7 for the transvers to the axial beam velocity ratio (=alpha) and a 2.3% axial velocity spread at 50 kV and 4 A. A magnetic field profile simulation was performed by using the Poisson code to obtain the grazing magnetic field of the entire interaction circuit with Poisson code.

  12. A high efficiency Ku-band radial line relativistic klystron amplifier

    Energy Technology Data Exchange (ETDEWEB)

    Dang, Fangchao; Zhang, Xiaoping, E-mail: zhangxiaoping@nudt.edu.cn; Zhong, Huihuang; Zhang, Jun; Ju, Jinchuan [College of Optoelectronic Science and Engineering, National University of Defense Technology, Changsha 410073 (China)

    2016-07-15

    To achieve the gigawatt-level microwave amplification output at Ku-band, a radial-line relativistic klystron amplifier is proposed and investigated in this paper. Different from the annular electron beam in conventional axial relativistic klystron amplifiers, a radial-radiated electron beam is employed in this proposed klystron. Owing to its radially spreading speciality, the electron density and space charge effect are markedly weakened during the propagation in the radial line drift tube. Additionally, the power capacity, especially in the output cavity, is enhanced significantly because of its large volume, which is profitable for the long pulse operation. Particle-in-cell simulation results demonstrate that a high power microwave with the power of 3 GW and the frequency of 14.25 GHz is generated with a 500 kV, 12 kA electron beam excitation and the 30 kW radio-frequency signal injection. The power conversion efficiency is 50%, and the gain is about 50 dB. Meanwhile, there is insignificant electron beam self-excitation in the proposed structure by the adoption of two transverse electromagnetic reflectors. The relative phase difference between the injected signals and output microwaves keeps stable after the amplifier saturates.

  13. Efficient gene replacements in ku70 disruption strain of Aspergillus chevalieri var. intermedius

    Directory of Open Access Journals (Sweden)

    Qingqing Huang

    2017-01-01

    Full Text Available Aspergillus chevalieri var. intermedius is a dominant filamentous fungal species in Fuzhuan tea and is associated with the quality and health benefits of this tea. The sexual or asexual reproduction of this fungus depends on the osmotic pressure of the tea. Efforts to enhance the beneficial effects of A. chevalieri var. intermedius are hampered by difficulties in disrupting its genes. To address this issue, we identified the A. chevalieri var. intermedius homolog (Acku70 of human Ku70 and generated an Acku70 disruption strain (ΔAcku70, aiming to improve the gene replacement efficiency. ΔAcku70 grew at a slightly lower rate in vitro than the wild-type strain; however, the two strains exhibited similar sensitivity to temperature, osmotic pressure and the effects of ethyl methane sulphonate and H2O2. The replacement efficiency of veA and flbA dramatically increased in ΔAcku70 compared to that in the wild type. The efficiency of flbA replacement increased from 2.6% to 80%, whereas the frequency of veA disruption increased from 15.2% to 83.9% and from 30.8% to 86.8%. Thus, ΔAcku70 is suitable for use as a type strain for large-scale functional genomic analysis of A. chevalieri var. intermedius.

  14. Relative agricultural aptitude of the Tuxpan municipality, Nayarit, using Almagra Model of the MicroLEIS System

    Directory of Open Access Journals (Sweden)

    José López García

    2012-02-01

    Full Text Available Agricultural land evaluation in the fluvial-marine plain within the municipality of Tuxpan, Nayarit, was carried out based onto a semi-detailed soil survey. Relative agricultural aptitude was evaluated, through out a modified Almagra’s model of MicroLeis 4.1 system, defining a new model: the Almagra-Tuxpan, based on the specific conditions of the zone. Using the Almagra-Tuxpan model, a software routine was written to evaluate the agricultural aptitude of twelve traditional crops (bean, sorghum, maize, tobacco (Virginia and Burley, chili, tomato, melon, watermelon, jícama, peanut, and cotton, after that, the relative agricultural aptitude was determined for every one of the mapped soils units. 21.73 % of the soils have a very good aptitude for the majority of the evaluated farming, 59.98 % have a moderate aptitude, and the remaining 18.43 % have no capacity at all. Generally speaking, excluding the units with null capacity, the soils of this municipality are suitable for farming cotton, maize and sorghum. The last two, are already intensely cultivated, meanwhile cotton will be a very good alternative for the region.

  15. Oxygen accumulation on metal surfaces investigated by XPS, AES and LEIS, an issue for sputter depth profiling under UHV conditions

    Science.gov (United States)

    Steinberger, R.; Celedón, C. E.; Bruckner, B.; Roth, D.; Duchoslav, J.; Arndt, M.; Kürnsteiner, P.; Steck, T.; Faderl, J.; Riener, C. K.; Angeli, G.; Bauer, P.; Stifter, D.

    2017-07-01

    Depth profiling using surface sensitive analysis methods in combination with sputter ion etching is a common procedure for thorough material investigations, where clean surfaces free of any contamination are essential. Hence, surface analytic studies are mostly performed under ultra-high vacuum (UHV) conditions, but the cleanness of such UHV environments is usually overrated. Consequently, the current study highlights the in principle known impact of the residual gas on metal surfaces (Fe, Mg, Al, Cr and Zn) for various surface analytics methods, like X-ray photoelectron spectroscopy (XPS), Auger electron spectroscopy (AES) and low-energy ion scattering (LEIS). The investigations with modern, state-of-the-art equipment showed different behaviors for the metal surfaces in UHV during acquisition: (i) no impact for Zn, even after long time, (ii) solely adsorption of oxygen for Fe, slight and slow changes for Cr and (iii) adsorption accompanied by oxide formation for Al and Mg. The efficiency of different counter measures was tested and the acquired knowledge was finally used for ZnMgAl coated steel to obtain accurate depth profiles, which exhibited before serious artifacts when data acquisition was performed in an inconsiderate way.

  16. Drogadição e atos infracionais na voz do adolescente em conflito com a lei

    Directory of Open Access Journals (Sweden)

    Sandra Eni Fernandes Nunes Pereira

    Full Text Available Por meio das abordagens sistêmica e psicossocial, o presente estudo tem como objetivo descrever e discutir a relação entre os níveis de dependência relacional das drogas e a prática de atos infracionais entre os jovens, na perspectiva do adolescente em conflito com a lei. As informações foram coletadas por entrevistas semi-estruturadas, aplicadas em 29 adolescentes, autores de infração, da Vara da Infância e Juventude de Brasília. O método de análise refere-se à análise de conteúdo do tipo construtivo-interpretativo. Os resultados apontam várias conexões entre os níveis de dependência relacional das drogas (efeitos, crenças, relações afetivas, pares, provedores, fornecedores e a prática de infrações. Os diferentes níveis de dependência identificados na voz dos adolescentes mostram a multiplicidade e complexidade das relações entre a drogadição e a prática de atos infracionais entre jovens e, portanto, a necessidade de um trabalho de intervenção em rede.

  17. Racismo de Estado e tanatopolítica: reflexões sobre os jovens e a lei

    Directory of Open Access Journals (Sweden)

    Andrea Cristina Coelho Scisleski

    2016-04-01

    Full Text Available Resumo O presente artigo busca discutir, a partir de pesquisa realizada no contexto de Campo Grande/Brasil, as políticas públicas dirigidas a jovens em conflito com a lei, tomando como operadores de análise os conceitos de racismo de Estado e de tanatopolítica, a partir do referencial teórico de Michel Foucault e de Giorgio Agamben, respectivamente. O texto discute como as políticas públicas vêm sendo destinadas a esses jovens, tanto pelas práticas que as implementam quanto pelas suas falhas e não cumprimento, vezes em que abandonam e desprotegem essa população. O debate centra-se em uma reflexão sobre a condição em que os jovens se encontram a partir de ações jurídico-políticas que os inserem em termos de vivência pela exclusão social. As reflexões finais do estudo apontam para uma forma de gestão não apenas da vida, mas também da morte desses jovens, que os mantém em uma situação de marginalidade, porém tutelada pelo Estado.

  18. Characterization of the roles of the catalytic domains of Mycobacterium tuberculosis ligase D in Ku-dependent error-prone DNA end joining.

    Science.gov (United States)

    Wright, Douglas; DeBeaux, Austin; Shi, Runhua; Doherty, Aidan J; Harrison, Lynn

    2010-09-01

    We previously established an Escherichia coli strain capable of re-circularizing linear plasmid DNA by expressing the Mycobacterium tuberculosis Ku (Mt-Ku) and Mycobacterium tuberculosis ligase D (Mt-LigD) proteins from the E.coli chromosome. Repair was predominately mutagenic due to deletions at the termini. We hypothesized that these deletions could be due to a nuclease activity of Mt-LigD that was previously detected in vitro. Mt-LigD has three domains: an N-terminal polymerase domain (PolDom), a central domain with 3'-phosphoesterase and nuclease activity and a C-terminal ligase domain (LigDom). We generated bacterial strains expressing Mt-Ku and mutant versions of Mt-LigD. Plasmid re-circularization experiments in bacteria showed that the PolDom alone had no re-circularization activity. However, an increase in the total and accurate repair was found when the central domain was deleted. This provides further evidence that this central domain does have nuclease activity that can generate deletions during repair. Deletion of only the PolDom of Mt-LigD resulted in a complete loss of accurate repair and a significant reduction in total repair. This is in agreement with published in vitro work indicating that the PolDom is the major Mt-Ku-binding site. Interestingly, the LigDom alone was able to re-circularize plasmid DNA but only in an Mt-Ku-dependent manner, suggesting a potential second site for Ku-LigD interaction. This work has increased our understanding of the mutagenic repair by Mt-Ku and Mt-LigD and has extended the in vitro biochemical experiments by examining the importance of the Mt-LigD domains during repair in bacteria.

  19. Modelování průtoků a vybraných parametrů jakosti vod na povodí Jenínského potoka modelem SWAT

    OpenAIRE

    HOMOLKA, Jan

    2014-01-01

    The thesis continues with the bachelor thesis which had dealt with preparation bases for simulation draining and carrying materials in SWAT model. Simulation should have been realized within basin of the Jenín stream, which watershed is 4,65 km2 large. SWAT model is primary developed for the larger watersheds where simulated values doesn't attain tolerances. Because of this is thesis focused on the methodic of simulation itself, discussion of the problem when is SWAT model almost useless for ...

  20. Low density lipoprotein receptor gene Ava II polymorphism and serum lipid levels in the Guangxi Bai Ku Yao and Han populations

    Directory of Open Access Journals (Sweden)

    Wu Dong-Feng

    2011-02-01

    Full Text Available Abstract Background Several common genetic polymorphisms in the low density lipoprotein receptor (LDL-R gene have associated with modifications of serum total cholesterol (TC and low density lipoprotein cholesterol (LDL-C levels, but the results are not consistent in different populations. Bai Ku Yao is a special subgroup of the Yao minority in China. The present study was undertaken to detect the association of LDL-R gene Ava Ⅱ polymorphism and serum lipid levels in the Guangxi Bai Ku Yao and Han populations. Methods A total of 1024 subjects of Bai Ku Yao and 792 participants of Han Chinese were randomly selected from our previous stratified randomized cluster samples. Genotyping of the LDL-R gene Ava Ⅱ polymorphism was performed by polymerase chain reaction and restriction fragment length polymorphism combined with gel electrophoresis, and then confirmed by direct sequencing. Results The levels of serum TC, high density lipoprotein cholesterol (HDL-C, LDL-C, apolipoprotein (Apo A1 and the ratio of ApoA1 to ApoB were lower in Bai Ku Yao than in Han (P - and A+ alleles was 65.5% and 34.5% in Bai Ku Yao, and 80.7% and 19.3% in Han (P -A-, A-A+ and A+A+ genotypes was 42.6%, 45.9% and 11.5% in Bai Ku Yao, and 64.9%, 31.6% and 3.5% in Han (P P 3.20 mmol/L subgroups in Bai Ku Yao (P P P P +A+ genotype had higher serum LDL-C, TC, HDL-C or ApoA1 levels than the subjects with A-A+ and A-A- genotypes. Spearman rank correlation analysis revealed that the levels of LDL-C in Bai Ku Yao and HDL-C in Han were correlated with genotypes (P P Conclusions The association of LDL-R gene Ava Ⅱ polymorphism and serum lipid levels is different between the Bai Ku Yao and Han populations. The discrepancy might partly result from different LDL-R gene Ava Ⅱ polymorphism or LDL-R gene-enviromental interactions.

  1. Effects of Snow/ Soil Interface on Microwave Backscatter of Terrestrial Snowpack at X- and Ku- Band

    Science.gov (United States)

    Kang, D. H.; Tan, S.; Zhu, J.; Gu, W.; Tsang, L.; Kim, E. J.

    2017-12-01

    Recent advances in monitoring and modeling capabilities to support remote sensing of terrestrial snow is encouraging to develop satellite mission concept in monitoring cold-region hydrological processes on global scales. However, it is still challenging to link back the active microwave backscattering signals to physical snowpack parameters. One of the limitations resides in the ignorance of the vegetation and soil conditions beneath the snowpack in the microwave scattering/ emission modeling and the snow water equivalent (SWE) retrieval algorithm. During the SnowEx 2017 winter campaign in Grand Mesa, CO, a particular effort has been made on comprehensive measurements of the underlying vegetation and soil characteristics from the snowpit measurements. Besides conducting standard snow core sampling, we have made additional protocols to record the background information beneath the snowpack. Recent works on active SWE retrieval algorithm using backscatters at X- (9.6 GHz) and Ku- (17.2 GHz) band suggest the significant signals from the background scattering characterization. The background scattering arising from the rough snow/ soil interface and the buried vegetation inside and beneath the snowpack modifies the sensitivity of the total backscatter to SWE. In this paper, we summarize the snow/ soil interface conditions as observed in the SnowEx campaign. We also develop standards for future in-situ snowpit measurements to include regular snow/ soil interface observations to accommodate the interpretation of microwave backscatter both for modeling and observation of microwave signatures. These observations first provide inputs to the microwave scattering models to predict the backscattering contribution from background, which is one of the key factors to be included to improve the SWE retrieval performance.

  2. Rainfall measurement from the opportunistic use of an Earth–space link in the Ku band

    Directory of Open Access Journals (Sweden)

    L. Barthès

    2013-08-01

    Full Text Available The present study deals with the development of a low-cost microwave device devoted to the measurement of average rain rates observed along Earth–satellite links, the latter being characterized by a tropospheric path length of a few kilometres. The ground-based power measurements, which are made using the Ku-band television transmissions from several different geostationary satellites, are based on the principle that the atmospheric attenuation produced by rain encountered along each transmission path can be used to determine the path-averaged rain rate. This kind of device could be very useful in hilly areas where radar data are not available or in urban areas where such devices could be directly placed in homes by using residential TV antenna. The major difficulty encountered with this technique is that of retrieving rainfall characteristics in the presence of many other causes of received signal fluctuation, produced by atmospheric scintillation, variations in atmospheric composition (water vapour concentration, cloud water content or satellite transmission parameters (variations in emitted power, satellite pointing. In order to conduct a feasibility study with such a device, a measurement campaign was carried out over a period of five months close to Paris. The present paper proposes an algorithm based on an artificial neural network, used to identify dry and rainy periods and to model received signal variability resulting from effects not related to rain. When the altitude of the rain layer is taken into account, the rain attenuation can be inverted to obtain the path-averaged rain rate. The rainfall rates obtained from this process are compared with co-located rain gauges and radar measurements taken throughout the full duration of the campaign, and the most significant rainfall events are analysed.

  3. Rainfall measurement from the opportunistic use of an Earth-space link in the Ku band

    Science.gov (United States)

    Barthès, L.; Mallet, C.

    2013-08-01

    The present study deals with the development of a low-cost microwave device devoted to the measurement of average rain rates observed along Earth-satellite links, the latter being characterized by a tropospheric path length of a few kilometres. The ground-based power measurements, which are made using the Ku-band television transmissions from several different geostationary satellites, are based on the principle that the atmospheric attenuation produced by rain encountered along each transmission path can be used to determine the path-averaged rain rate. This kind of device could be very useful in hilly areas where radar data are not available or in urban areas where such devices could be directly placed in homes by using residential TV antenna. The major difficulty encountered with this technique is that of retrieving rainfall characteristics in the presence of many other causes of received signal fluctuation, produced by atmospheric scintillation, variations in atmospheric composition (water vapour concentration, cloud water content) or satellite transmission parameters (variations in emitted power, satellite pointing). In order to conduct a feasibility study with such a device, a measurement campaign was carried out over a period of five months close to Paris. The present paper proposes an algorithm based on an artificial neural network, used to identify dry and rainy periods and to model received signal variability resulting from effects not related to rain. When the altitude of the rain layer is taken into account, the rain attenuation can be inverted to obtain the path-averaged rain rate. The rainfall rates obtained from this process are compared with co-located rain gauges and radar measurements taken throughout the full duration of the campaign, and the most significant rainfall events are analysed.

  4. Estimating Snow Water Equivalent with Backscattering at X and Ku Band Based on Absorption Loss

    Directory of Open Access Journals (Sweden)

    Yurong Cui

    2016-06-01

    Full Text Available Snow water equivalent (SWE is a key parameter in the Earth’s energy budget and water cycle. It has been demonstrated that SWE can be retrieved using active microwave remote sensing from space. This necessitates the development of forward models that are capable of simulating the interactions of microwaves and the snow medium. Several proposed models have described snow as a collection of sphere- or ellipsoid-shaped ice particles embedded in air, while the microstructure of snow is, in reality, more complex. Natural snow usually forms a sintered structure following mechanical and thermal metamorphism processes. In this research, the bi-continuous vector radiative transfer (bi-continuous-VRT model, which firstly constructs snow microstructure more similar to real snow and then simulates the snow backscattering signal, is used as the forward model for SWE estimation. Based on this forward model, a parameterization scheme of snow volume backscattering is proposed. A relationship between snow optical thickness and single scattering albedo at X and Ku bands is established by analyzing the database generated from the bi-continuous-VRT model. A cost function with constraints is used to solve effective albedo and optical thickness, while the absorption part of optical thickness is obtained from these two parameters. SWE is estimated after a correction for physical temperature. The estimated SWE is correlated with the measured SWE with an acceptable accuracy. Validation against two-year measurements, using the SnowScat instrument from the Nordic Snow Radar Experiment (NoSREx, shows that the estimated SWE using the presented algorithm has a root mean square error (RMSE of 16.59 mm for the winter of 2009–2010 and 19.70 mm for the winter of 2010–2011.

  5. Análise crítica do discurso em dois textos penais sobre a Lei Maria da Penha

    Directory of Open Access Journals (Sweden)

    Lúcia Freitas

    2013-01-01

    Full Text Available Neste trabalho, aplico uma análise linguístico-discursiva a dois textos judiciais: 1 um "pedido de reconsideração" de um promotor feito a um juiz; 2 a "decisão" do juiz em resposta ao promotor. Os dois textos fazem parte do corpus de um estudo maior financiado pelo edital MCT/CNPq/SPM-PR/MDA nº. 57/2008 CNPq que analisou 25 processos (cerca de 200 documentos jurídicos enquadrados na Lei Maria da Penha. O viés teórico-analítico baseia-se na Análise de Discurso Crítica (FAIRCLOUGH, 2003, uma forma de pesquisa que situa material linguístico-discursivo em práticas sociais e focaliza-o dentro de estruturas sociopolíticas mais abrangentes de poder. Nessa linha de estudo é fundamental a noção de que significado linguístico e ideologia são entidades inseparáveis e mutuamente dependentes da estrutura social, estando ambas impressas na própria estrutura textual. Nessa direção, o trabalho se concentra nos modos de operação da ideologia nos textos que revelam as constituições subjetivas dos operadores do Direito e suas intenções. Alguns focos analíticos recaem sobre os arranjos linguísticos usados na representação de atores sociais, recursos avaliativos, as estratégias de proteção de face e polidez. Os resultados discutem criticamente os fundamentos básicos que orientam a cultura jurídica, como "igualdade de direitos", "consenso", "objetividade", "neutralidade" e "transparência".

  6. Análise crítica do discurso em dois textos penais sobre a Lei Maria da Penha

    Directory of Open Access Journals (Sweden)

    Lúcia Gonçalves Freitas

    2013-01-01

    Full Text Available Neste trabalho, aplico uma análise linguístico-discursiva a dois textos judiciais: 1 um “pedido de reconsideração” de um promotor feito a um juiz; 2 a “decisão” do juiz em resposta ao promotor. Os dois textos fazem parte do corpus de um estudo maior financiado pelo edital MCT/CNPq/SPM-PR/MDA nº. 57/2008 CNPq que analisou 25 processos (cerca de 200 documentos jurídicos enquadrados na Lei Maria da Penha. O viés teórico-analítico baseia-se na Análise de Discurso Crítica (FAIRCLOUGH, 2003, uma forma de pesquisa que situa material linguístico-discursivo em práticas sociais e focaliza-o dentro de estruturas sociopolíticas mais abrangentes de poder. Nessa linha de estudo é fundamental a noção de que significado linguístico e ideologia são entidades inseparáveis e mutuamente dependentes da estrutura social, estando ambas impressas na própria estrutura textual. Nessa direção, o trabalho se concentra nos modos de operação da ideologia nos textos que revelam as constituições subjetivas dos operadores do Direito e suas intenções. Alguns focos analíticos recaem sobre os arranjos linguísticos usados na representação de atores sociais, recursos avaliativos, as estratégias de proteção de face e polidez. Os resultados discutem criticamente os fundamentos básicos que orientam a cultura jurídica, como “igualdade de direitos”, “consenso”, “objetividade”, “neutralidade” e “transparência”.

  7. Oxygen accumulation on metal surfaces investigated by XPS, AES and LEIS, an issue for sputter depth profiling under UHV conditions

    Energy Technology Data Exchange (ETDEWEB)

    Steinberger, R., E-mail: roland.steinberger@jku.at [Center for Surface and Nanoanalytics, Johannes Kepler University Linz, Altenberger Straße 69, 4040 Linz (Austria); Celedón, C.E., E-mail: carlos.celedon@usm.cl [Institut für Experimentalphysik, Abteilung für Atom- und Oberflächenphysik, Johannes Kepler University Linz, Altenberger Straße 69, 4040 Linz (Austria); Departamento de Física, Universidad Técnica Federico Santa María, Valaparaíso, Casilla 110-V (Chile); Bruckner, B., E-mail: barbara.bruckner@jku.at [Institut für Experimentalphysik, Abteilung für Atom- und Oberflächenphysik, Johannes Kepler University Linz, Altenberger Straße 69, 4040 Linz (Austria); Roth, D., E-mail: dietmar.roth@jku.at [Institut für Experimentalphysik, Abteilung für Atom- und Oberflächenphysik, Johannes Kepler University Linz, Altenberger Straße 69, 4040 Linz (Austria); Duchoslav, J., E-mail: jiri.duchoslav@jku.at [Center for Surface and Nanoanalytics, Johannes Kepler University Linz, Altenberger Straße 69, 4040 Linz (Austria); Arndt, M., E-mail: martin.arndt@voestalpine.com [voestalpine Stahl GmbH, voestalpine-Straße 3, 4031 Linz (Austria); Kürnsteiner, P., E-mail: p.kuernsteiner@mpie.de [Center for Surface and Nanoanalytics, Johannes Kepler University Linz, Altenberger Straße 69, 4040 Linz (Austria); and others

    2017-07-31

    Highlights: • Investigation on the impact of residual gas prevailing in UHV chambers. • For some metals detrimental oxygen uptake could be observed within shortest time. • Totally different behavior was found: no changes, solely adsorption and oxidation. • The UHV residual gas may severely corrupt results obtained from depth profiling. • A well-considered data acquisition sequence is the key for reliable depth profiles. - Abstract: Depth profiling using surface sensitive analysis methods in combination with sputter ion etching is a common procedure for thorough material investigations, where clean surfaces free of any contamination are essential. Hence, surface analytic studies are mostly performed under ultra-high vacuum (UHV) conditions, but the cleanness of such UHV environments is usually overrated. Consequently, the current study highlights the in principle known impact of the residual gas on metal surfaces (Fe, Mg, Al, Cr and Zn) for various surface analytics methods, like X-ray photoelectron spectroscopy (XPS), Auger electron spectroscopy (AES) and low-energy ion scattering (LEIS). The investigations with modern, state-of-the-art equipment showed different behaviors for the metal surfaces in UHV during acquisition: (i) no impact for Zn, even after long time, (ii) solely adsorption of oxygen for Fe, slight and slow changes for Cr and (iii) adsorption accompanied by oxide formation for Al and Mg. The efficiency of different counter measures was tested and the acquired knowledge was finally used for ZnMgAl coated steel to obtain accurate depth profiles, which exhibited before serious artifacts when data acquisition was performed in an inconsiderate way.

  8. THE ANALYSIS OF TOTAL EXPENSES AT 1000 LEI TOTAL REVENUES AND OF THE RESULT OF THE GROWTH OF THEIR EFFICIENCY

    Directory of Open Access Journals (Sweden)

    LĂPĂDUŞI MIHAELA LOREDANA

    2013-12-01

    Full Text Available act The analysis of the company’s expenses is mainly important in the management and control activity, because it highlights the way in which are used the resources (material, human, financial and the impact of their allocation on the company’s performances. The optimization of the level of costs or the their reduction, where it is possible, without affecting the quality of the products and working conditions of the activity, represent the primary objectives of the management of companies.[9] Expenses have been and will remain one of the key indicators of a company requiring continuous application of a control and monitoring mechanism because when it comes to expenses we never speak of their growth, but their reduction. This reduction is the main objective of any economic agent that will result in increasing the efficiency of the entire activity. The costs of a company reflect in cash the total consumption of material, human and financial resources used in manufacturing and selling of the products. The level, dynamics and structure of these expenses reflect synthetically the activity of industrial enterprises when using effectively the available resources. The purpose of this article is to analyze synthetically a company's expenses efficiency based on the efficiency ratio of total expenses at 1000 lei total revenues and the purpose of the article results in a set of conclusions that will highlight a number of important issues concerning the role and the importance of the efficiency of total expenses related to total revenue, as well as the result of the growth of the efficiency of total expenses.

  9. Lei de Acesso à Informação nos Municípios do Extremo Oeste de Santa Catarina

    Directory of Open Access Journals (Sweden)

    Deneide Teresinha de Carli

    2016-04-01

    Full Text Available A Lei de Acesso à Informação (LAI, nº 12.527, de 18/11/2011, regula o acesso a informações públicas em todos os âmbitos do Poder Público. Objetivou investigar de que forma a LAI é disponibilizada nas prefeituras catarinenses integrantes da Associação dos Municípios do Extremo Oeste de Santa Catarina (AMEOSC. Trata-se de uma pesquisa descritiva, documental e quantitativa. Utilizou checklist e questionário aplicado às 13 prefeituras da AMEOSC, que formaram o universo desta pesquisa. Fundamentou-se a revisão de literatura abordando sobre a LAI, a gestão documental arquivística e os ciclos de vida dos documentos. Dos 13 questionários aplicados, responderam seis prefeituras, (três possuem população acima de dez mil, obrigadas a disponibilizar o acesso à LAI e três abaixo de dez mil. Conclui-se que é cedo para fazer uma ampla avaliação da disponibilização da LAI nos municípios pesquisados, visto que a mesma foi aprovada em 2011. As prefeituras estão se estruturando para atender as demandas. Considerou-se como obstáculos a insuficiência de recursos humanos, inadequada divulgação e conscientização dos servidores e da população em geral.

  10. Reparabilidade do dano ambiental no sistema da responsabilização civil: 25 anos da lei 6938/1981

    Directory of Open Access Journals (Sweden)

    Luciana Cardoso Pilati

    2006-12-01

    Full Text Available O presente artigo trata da evolução daresponsabilização civil ambiental noordenamento jurídico brasileiro. Procurasistematizar os aspectos relacionados à reparaçãodo meio ambiente, a partir de uma visãopanorâmica. Nesse passo, trata, inicialmente, dohistórico da responsabilização civil ambiental noBrasil, com enfoque para a Lei da Política Nacionaldo Meio Ambiente e para as funções daresponsabilidade civil. Em seguida, analisa o danoambiental, sua conceituação e classificação.Examina, a seguir, as formas de reparação do dano,destacando a prevalência da restauração in natura,assim como alguns julgados concernentes ao tema.Por fim, aborda – em função da sua atualidade –a questão do dano moral extrapatrimonialcoletivo, aduzindo julgados que já contemplarama sua reparabilidade.The present article deals with the evolutionof the ambient civil responsabilização in the Brazilianlegal system. Search systemize the aspects relatedto the repairing of the environment, from apanoramic vision. In this step, it treats, initially, ofthe description of the ambient civil responsabilizaçãoin Brazil, with approach for the Law of the NationalPolitics of the Environment and for the functions ofthe civil liability. After that, it analyzes the ambientdamage, its conceptualization and classification. Itexamines, to follow, the forms of repairing of thedamage, detaching the prevalence of the restorationin natura, as well as some concernentes judgeshipsto the subject. Finally, it approaches – in function ofits present time – the question of the collectiveextrapatrimonial pain and suffering, alleging judgedthat already they had contemplated its repairability.

  11. Aplicação da Lei Maria da Penha nas delegacias de mulheres: O caso do Rio de Janeiro

    Directory of Open Access Journals (Sweden)

    Cláudia Abdala

    2011-10-01

    Full Text Available O artigo analisa a trajetória das queixas de violência conjugal prestadas por mulheres em cinco DEAMs do estado do Rio de Janeiro. São discutidos: o número de queixas realizadas e efetivamente transformadas em registros de ocorrência no período de 2005-2008; os diversos obstáculos encontrados pelas mulheres para tornar públicos os maus-tratos que sofrem e o impacto da sanção da Lei Maria da Penha no número de registros de ocorrência nessas delegacias. O estudo mostrou o risco que ainda hoje uma mulher corre quando decide denunciar a violência. Buscou-se também destacar o quanto à violência psicológica contra a mulher é naturalizada nas delegacias.  The article Application of the Maria da Penha Law at Police Stations for Women in Rio de Janeiro reviews the history of complaints of domestic violence reported by women in five DEAMs (special police stations for women in Rio de Janeiro state, Brazil. The study investigates the number of complaints made and effectively transformed into reports in the period 2005-2008, the various obstacles faced by women to make known the abuse they suffer and the impact of the sanctioning of the Maria da Penha Act on the number those reports. The study demonstrates the risk that women still run when they decide to report violence and the extent to which psychological abuse against women is naturalized in the police stations. Key words: domestic violence, complaints, Maria da Penha Act, Rio de Janeiro, police stations for women

  12. Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017; Venice (Italy; October 31-November 4, 2017; Session "Ethics"

    Directory of Open Access Journals (Sweden)

    --- Various Authors

    2017-10-01

    Full Text Available Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017; Venice (Italy; October 31-November 4, 201758th ESPR Annual Meeting, 7th International Congress of UENPS, 3rd International Congress of EFCNIORGANIZING INSTITUTIONSEuropean Society for Paediatric Research (ESPR, European Society for Neonatology (ESN, Union of European Neonatal & Perinatal Societies (UENPS, European Foundation for the Care of Newborn Infants (EFCNIORGANIZING COMMITTEELuc Zimmermann (President of ESPR, Morten Breindahl (President of ESN, Manuel Sánchez Luna (President of UENPS, Silke Mader (Chairwoman of the Executive Board and Co-Founder of EFCNISCIENTIFIC COMMITTEEVirgilio P. Carnielli (Congress President Chair, Pierre Gressens (Past Scientific President, Umberto Simeoni, Manon Benders, Neil Marlow, Ola D. Saugstad, Petra Hüppi, Agnes van den HoogenSession "Ethics"ABS 1. THE DELIVERY OF BAD NEWS: A ONE OR 2-STEP APPROACH? THE CASE FOR TRISOMY 21 • M.S. Schimmel, M.Y. Kassirer, H.M. TowersABS 2. NEONATAL ORGAN DONATION: A POTENTIAL NEW DONOR SOURCE FOR CELL AND ORGAN TRANSPLANTATION • C. Jorns, E. Henckel, G. Nowak, A. Karadagi, T. Kjellin, E. Bluhme, Ö. Jynge, M. Hending, A. Croon, M. Söderström, B. Fischler, A. Nemeth, R. Gramignoli, S. Strom, E. Ellis, B. HallbergABS 3. HEALTH CARE PROFESSIONALS’ AND PARENTS’ ATTITUDES TOWARD PARENTAL AUTONOMY AND THE BEST INTEREST OF THE EXTREME PRETERM INFANT: A NATIONAL STUDY IN SWITZERLAND • M. Hendriks, H. Bucher, S. Klein, R. Baumann-Holzle, J. Streuli, J. FauchèreABS 4. CHANGING PARENTAL PERCEPTIONS IN TRISOMIES – A POTENTIAL ETHICAL DILEMMA FOR NEONATOLOGISTS? • E. Simons, P. Nath, P. ParthasarathyABS 5. INGEBORG SYLLM-RAPOPORT (1912-2017 – AN EXEMPLARY LIFE FOR CHILDREN AND PAEDIATRICS • H. Sallmon, R.R. Wauer, C.C. RoehrABS 6. RETROSPECTIVE ANALYSES OF PARENTAL COUNSELING AND DECISION MAKING FOR EXTREME PRETERM BIRTH IN A TERTIARY DUTCH PERINATAL CENTER • E. de Booij, J

  13. Apigenin induces apoptosis by targeting inhibitor of apoptosis proteins and Ku70–Bax interaction in prostate cancer

    Science.gov (United States)

    Shukla, Sanjeev; Fu, Pingfu; Gupta, Sanjay

    2014-01-01

    Dysfunction of the apoptotic pathway in prostate cancer cells confers apoptosis resistance towards various therapies. A novel strategy to overcome resistance is to directly target the apoptotic pathway in cancer cells. Apigenin, an anticancer agent, selectively toxic to cancer cells induces cell cycle arrest and apoptosis through mechanisms which are not fully explored. In the present study we provide novel insight into the mechanisms of apoptosis induction by apigenin. Treatment of androgen-refractory human prostate cancer PC-3 and DU145 cells with apigenin resulted in dose-dependent suppression of XIAP, c-IAP1, c-IAP2 and survivin protein levels. Apigenin treatment resulted in significant decrease in cell viability and apoptosis induction with the increase of cytochrome C in time-dependent manner. These effects of apigenin were accompanied by decrease in Bcl-xL and Bcl-2 and increase in the active form of Bax protein. The apigenin-mediated increase in Bax was due to dissociation of Bax from Ku70 which is essential for apoptotic activity of Bax. Apigenin treatment resulted in the inhibition of class I histone deacetylases and HDAC1 protein expression, thereby increasing the acetylation of Ku70 and the dissociation of Bax resulting in apoptosis of cancer cells. Furthermore, apigenin significantly reduced HDAC1 occupancy at the XIAP promoter, suggesting that histone deacetylation might be critical for XIAP downregulation. These results suggest that apigenin targets inhibitor of apoptosis proteins and Ku70–Bax interaction in the induction of apoptosis in prostate cancer cells and in athymic nude mouse xenograft model endorsing its in vivo efficacy. PMID:24563225

  14. Evaluation of genetic alteration induced by radon gas using the micronucleus test (Tradescantia sp. clone KU-20)

    International Nuclear Information System (INIS)

    Bruschi, Armando L.; Azevedo, Heliana de; Macacini, Jose F.; Roque, Claudio V.

    2011-01-01

    The first observations over the existence of radon gas (Rn), initially known as 'thorium emanation', were carried out between the end of 19 th and beginning of 20 th centuries. A result of uranium-238 (U 238 ) radioactive decay, radon is a tasteless, odorless and colorless gas under room temperature, with a 3.825-day half life and particle α emission in its decay, and as final product of its disintegration, the stable lead-206 isotope (Pb 206 ). Being it is the gas with the highest density known, closed and poor ventilated environments are favorable to its accumulation, with its inhalation being the highest health risk. The use of vegetal bioindicators has shown to be excellent on the monitoring of air quality and on mutagenic potential of various pollutants contained in the atmosphere. Within this context, the objective of this study was to evaluate the micronucleus test application potential utilizing the Tradescantia sp. clone KU-20, in order to evaluate genetic alterations induced by radon gas. Stems of Tradescantia sp. clone KU-20, previously immerse in Hoagland solution, were introduced in a radon detection equipment's calibration chamber (Alphaguard), containing radium salt. Afterwards, the accommodated stems were exposed to radon gas (the average radon concentration was 7.639 KBq/m3) for 24 hours. The results demonstrated an increase on micronucleus formation (39.23 + 2.143 MCN/100 tetrads) in stems exposed in relation to the negative control (18.00 + 1.396 MCN/100 tetrads). The difference between the values indicated a significant increase on micronucleus frequency in the inflorescences subjected to radon gas. The presented results demonstrated the micronucleus test application potential using Tradescantia clone KU-20 to evaluate genetic effects induced by radon gas. (author)

  15. Study of the Effect of Simulated Rain on the Offset Parabolic Antenna at Ku-Band with Different Elevation Angles

    Directory of Open Access Journals (Sweden)

    H. Mostafa

    2007-01-01

    Full Text Available Effect of rain on the receiver antenna is a major factor to degrade the system performance in a frequency above 10 GHz. This paper deals with the wet antenna attenuation at Ku-band with three different frequencies at different rain rates. During the Ku-band propagation experiment, it was discovered that rain water on the antenna caused a significant attenuation. It is necessary to estimate the losses caused by water on the antenna in order to separate these losses from the atmospheric propagation losses. The experiment was done at USM Engineering Campus to study the attenuation for these physical parameters. A Ku-band RF signal was generated by a signal generator and transmitted via horn antenna. The signal was received using a smooth offset antenna of 60 cm by 54 cm (Astro dish and measured using spectrum analyzer. In order to simulate a rain, pipes with bores of a same distance were implemented. Three cases were considered: in the first case one pipe was used to simulate low rain rate, the second case two pipes were used to simulate medium rain rate, and the third case three pipes were used to simulate heavy rain rate. In addition, the tap was used to control the flow of water in order to get more values of rain rate. The total attenuation of RF signals due to water layer on the feed and on the reflector feed was found to be 3.1 dB at worst case. On the other hand, the attenuation of RF signal due to the feed only was 2.83 dB, so the major attenuation occur was due to feed.

  16. Effects of surface roughness on sea ice freeboard retrieval with an Airborne Ku-Band SAR radar altimeter

    DEFF Research Database (Denmark)

    Hendricks, Stefan; Stenseng, Lars; Helm, Veit

    2010-01-01

    to investigate sea ice volume changes on an Arctic wide scale. Freeboard retrieval requires precise radar range measurements to the ice surface, therefore we investigate the penetration of the Ku-Band radar waves into the overlying snow cover as well as the effects of sub-footprint-scale surface roughness using...... airborne radar and laser altimeters. We find regional variable penetration of the radar signal at late spring conditions, where the difference of the radar and the reference laser range measurement never agrees with the expected snow thickness. In addition, a rough surface can lead to biases...

  17. Pirmsskolas vecuma bērnu vecāku emocionālais intelekts un stresa līmenis saistībā ar vecāku audzināšanas pieejām

    OpenAIRE

    Pastare, Ilze

    2007-01-01

    Rezumējums Pētījuma mērķis bija noskaidrot pirmsskolas vecuma bērnu vecāku emocionālā intelekta un stresa līmeņa rādītāju saistību ar audzināšanas pieejām. Kopā pētījumā piedalījās 41 māte. Vidējais vecums mātēm – 33 gadi, bērnu vidējais vecums – 5 gadi. Pētījumā tika izmantotas šādas metodes: “ Bar-On Emocionālā intelekta aptauja”, “Vecāku stresa indekss”, “ Alabamas audzināšanas aptaujas pirmsskolas versija”. Pētījumā tika noskaidrots, ka pastāv statistiski nozīmīga po...

  18. Medida de calor específico e lei de resfriamento de Newton: um refinamento na análise dos dados experimentais

    Directory of Open Access Journals (Sweden)

    Silva Wilton Pereira da

    2003-01-01

    Full Text Available Uma das técnicas para a determinação do calor específico de sólidos e líquidos dispensa o uso de um calorímetro e utiliza a lei de resfriamento de Newton na análise dos dados experimentais. O sucesso desta técnica pressupõe que seja possível determinar, com pequenas incertezas, as temperaturas do sistema imediatamente antes e imediatamente depois das transferências internas de calor devido à imersão do corpo (dujo calor específico se deseja medir em um recipiente contendo água quente. Neste artigo é proposto um refinamento desta técnica utilizando-se dois ajustes de curvas para a função que descreve a lei de resfriamento, com pequenas extrapolações, para de determinar essas temperaturas e também as suas incertezas. Isto possibilita determinar não só o valor médio do calor específico, mas também a incerteza deste valor médio, por propagação de erros. O ajuste da própria função que descreve a lei de resfriamento aos dados possibilitou a comparação imediata dos parâmetros obtidos experimentalmente com aqueles previstos pela teoria, e há uma grande concerdânciaentre eles. A aplicaçãodeste refinamento na determinação do calor específico do alumínio indica que tal procedimento é eficaz mesmo quando se trabalha com instrumentos de baixo custo, voltados para o ensino.

  19. A FALTA DE EFETIVIDADE DA LEI MARIA DA PENHA: UMA PENA JUSTA É AQUELA QUE RESTABELECE OS LAÇOS DESFEITOS PELO CRIME

    Directory of Open Access Journals (Sweden)

    Adriana Maria Santos Pertel

    2012-10-01

    Full Text Available Trata-se de um estudo da aplicabilidade da Justiça Restaurativa, no caso de crime de lesão corporal leve praticado contra a mulher no âmbito doméstico ou familiar, tendo como ponto central a vítima e não a lei, analisando a vontade daquela, como pressuposto primeiro, para a manutenção ou não dos laços afetivos que a prendem ao seu agressor. Destaca-se o julgamento da Ação Direta de Inconstitucionalidade n. 4.424, que proporciona uma nova leitura ao artigo 16 da Lei Maria da Penha, o qual autoriza o Ministério Público a instaurar a ação pública, sem necessidade de representação da vítima, excluindo-a do processo e, consequentemente, desconsiderando sua capacidade de realizar escolhas na vida. Esse entendimento atribuído pela Suprema Corte contraria a nova filosofia da Criminologia crítica, baseada em princípios de conciliação e mediação, com o objetivo de humanizar a pena e fazer com que a vítima participe da construção da solução do conflito, bem como de buscar o sentimento de responsabilidade, respeito e arrependimento do agressor. Palavras-chave: Justiça restaurativa. Vitimização. Lei Maria da Penha. Judiciário.

  20. Differential gene expression in a DNA double-strand-break repair mutant XRS-5 defective in Ku80. Analysis by cDNA microarray

    Energy Technology Data Exchange (ETDEWEB)

    Chan, John Y.H.; Chen, Lung-Kun; Chang, Jui-Feng [National Yang Ming Univ., Taipei, Taiwan (China). Inst. of Radiological Sciences] (and others)

    2001-12-01

    The ability of cells to rejoin DNA double-strand breaks (DSBs) usually correlates with their radiosensitivity. This correlation has been demonstrated in radiosensitive cells, including the Chinese hamster ovary mutant XRS-5. XRS-5 is defective in a DNA end-binding protein, Ku80, which is a component of a DNA-dependent protein kinase complex used for joining strand breaks. However, Ku80-deficient cells are known to be retarded in cell proliferation and growth as well as other yet to be identified defects. Using custom-made 600-gene cDNA microarray filters, we found differential gene expressions between the wild-type and XRS-5 cells. Defective Ku80 apparently affects the expression of several repair genes, including topoisomerase-I and -IIA, ERCC5, MLH1, and ATM. In contrast, other DNA repair-associated genes, such as GADD45A, EGR1 MDM2 and p53, were not affected. In addition, for large numbers of growth-associated genes, such as cyclins and clks, the growth factors and cytokines were also affected. Down-regulated expression was also found in several categories of seemingly unrelated genes, including apoptosis, angiogenesis, kinase and signaling, phosphatase, stress protein, proto-oncogenes and tumor suppressors, transcription and translation factors. A RT-PCR analysis confirmed that the XRS-5 cells used were defective in Ku80 expression. The diversified groups of genes being affected could mean that Ku80, a multi-functional DNA-binding protein, not only affects DNA repair, but is also involved in transcription regulation. Our data, taken together, indicate that there are specific genes being modulated in Ku80- deficient cells, and that some of the DNA repair pathways and other biological functions are apparently linked, suggesting that a defect in one gene could have global effects on many other processes. (author)

  1. Differential gene expression in a DNA double-strand-break repair mutant XRS-5 defective in Ku80. Analysis by cDNA microarray

    International Nuclear Information System (INIS)

    Chan, John Y.H.; Chen, Lung-Kun; Chang, Jui-Feng

    2001-01-01

    The ability of cells to rejoin DNA double-strand breaks (DSBs) usually correlates with their radiosensitivity. This correlation has been demonstrated in radiosensitive cells, including the Chinese hamster ovary mutant XRS-5. XRS-5 is defective in a DNA end-binding protein, Ku80, which is a component of a DNA-dependent protein kinase complex used for joining strand breaks. However, Ku80-deficient cells are known to be retarded in cell proliferation and growth as well as other yet to be identified defects. Using custom-made 600-gene cDNA microarray filters, we found differential gene expressions between the wild-type and XRS-5 cells. Defective Ku80 apparently affects the expression of several repair genes, including topoisomerase-I and -IIA, ERCC5, MLH1, and ATM. In contrast, other DNA repair-associated genes, such as GADD45A, EGR1 MDM2 and p53, were not affected. In addition, for large numbers of growth-associated genes, such as cyclins and clks, the growth factors and cytokines were also affected. Down-regulated expression was also found in several categories of seemingly unrelated genes, including apoptosis, angiogenesis, kinase and signaling, phosphatase, stress protein, proto-oncogenes and tumor suppressors, transcription and translation factors. A RT-PCR analysis confirmed that the XRS-5 cells used were defective in Ku80 expression. The diversified groups of genes being affected could mean that Ku80, a multi-functional DNA-binding protein, not only affects DNA repair, but is also involved in transcription regulation. Our data, taken together, indicate that there are specific genes being modulated in Ku80- deficient cells, and that some of the DNA repair pathways and other biological functions are apparently linked, suggesting that a defect in one gene could have global effects on many other processes. (author)

  2. Synergistic effects of methyl methanesulfonate and X rays in inducing somatic mutations in the stamen hairs of Tradescantia clones, KU 27 and BNL 4430

    International Nuclear Information System (INIS)

    Ichikawa, Sadao; Yamaguchi, Akihiko; Okumura, Mikiko

    1993-01-01

    Young influorescences of Tradescantia clones KU 27 and BNL 4430, the both of which are blue/pink heterozygotes and have been demonstrated to be highly sensitive to alkylating agents, were exposed either to aqueous solutions of methyl methanesulfonate (MMS) for 16 hr alone (at 0.005 to 0.02% for KU 27 and at 0.005% for BNL 4430) or to acute 150 kVp X rays alone (161 to 531 mGy for Ku 27 and 501 to 976 mGy for BNL 4430), or in combinations (134 to 448 mGy for KU 27 and 458 to 865 mGy for BNL 4430 after the 0.005% MMS treatment). The induced somatic pink mutation frequencies per hair-cell division were studied and compared, and clone BNL 4430 was found to be nearly two times more sensitive to MMS than clone KU 27, while the X-ray-induced mutation frequencies in the latter was about 1.5 times higher than those in the former. The lower sensitivity to MMS of clone KU 27 (as compared with BNL 4430) was nevertheless about 5.6 times higher as compared with the responses of clone BNL 02 to MMS reported earlier, proving the high sensitivities of the two clones used in the present study. Clear synergistic effects of MMS and X rays were observed in the both clones, indicating that the mechanisms of inducing mutations are common at least in part between MMS and X rays. (author)

  3. O regime do recurso de agravo a partir das alteraçãoes introduzidas pela lei 11.187/2005

    OpenAIRE

    Ana Luiza Duarte Pires de Castro

    2011-01-01

    O direito processual civil é um ramo dinâmico do direito que busca ajustar-se às mudanças da sociedade e tem o fito de, pacificamente, solucionar os litígios que a ela se apresentam. Nesse norte, em virtude de estar sempre em busca de prestar uma tutela jurisdicional mais eficaz, o legislador pretendeu, através da edição da Lei 11.187/2005 - a qual disciplina o novo regime do recurso de agravo, dar maior celeridade processual. Para tanto, restringiu o uso do agravo de instrumento (caput do...

  4. A LEI DE CRIMES AMBIENTAIS E ANÁLISE DA EFETIVIDADE JURÍDICO-ECONÔMICA A PARTIR DE MODELOS ECONOMÉTRICOS

    Directory of Open Access Journals (Sweden)

    Dacicleide Souza Cunha

    2014-04-01

    Full Text Available A pesquisa tem como objetivo estudar a efetividade da Lei de Crimes Ambientais (9.605/98 aplicada a crimes contra a flora no estado do Amapá no período entre 2000 e 2008. A metodologia do estudo consistiu nas seguintes etapas: a obtenção de dados sobre os Autos de Infração contra a flora (banco de dados do IBAMA-AP, b análise da cobrança cível, c análise da impetração de ação criminal pelos Ministérios Públicos Estadual e Federal e d verificação de etapas de procedimentos e conclusão dos processos cíveis e criminais, utilizando probabilidades de sucesso e insucesso. Como resultado foram desenvolvidos dois modelos conceituais econométricos, um cívil e um criminal, ambos aplicados na análise da efetividade da Lei a partir de cenários jurídico-econômicos. Parâmetros econométricos, como montante da multa, taxa de juros (%a.m e período de aplicação da multa foram utilizados nos modelos, bem como probabilidades observacionais relacionadas com o nível de sucesso de cada etapa dos processos cívis e criminais. Os resultados da aplicação dos modelos econométricos propostos representam razoavelmente bem os riscos de efetividade da Lei, com base em números de autuações, condenações penais e pagamento das multas cíveis. Por esta perspectiva, os instrumentos administrativos e criminais mostraram reduzida efetividade, com poucas condenações, provavelmente incrementada pela complexidade jurídica do setor no sistema brasileiro. Conclui-se que há falhas consideráveis no cumprimento de procedimentos administrativos e judiciais, mas que podem ser relativamente bem explicadas pelos modelos econométricos propostos. Palavras-chave: Amazônia Oriental, Lei de Crimes Ambientais, efetividade, modelo matemático. DOI: http://dx.doi.org/10.18561/2179-5746/biotaamazonia.v4n1p50-64

  5. Representações de indígenas na ficção e na lei: em quadrinhos e no estatuto do índio

    OpenAIRE

    Mina, Sandra Regina Nóia

    2014-01-01

    O intuito deste trabalho é problematizar as representações sobre o índio presentes na Lei nº 6.001, de 1973, conhecida como Estatuto do Índio (EI) e nas Histórias em Quadrinhos (HQ) da Turma de Papa Capim, de Mauricio de Sousa. Para tanto, temos como objetivo específico interpretar como são construídas as representações sobre o índio que constituem o discurso do documento oficial EI e o discurso das HQ, a partir da perspectiva discursiva, dos Estudos Culturais e do processo de referenciação l...

  6. Entre o terreiro e a escola: Lei 10.639/2003 e intolerância religiosa sob o olhar antropológico

    OpenAIRE

    Araújo, Patrício Carneiro

    2015-01-01

    Resultado de uma pesquisa de doutorado, este trabalho trata sobre a Lei 10.639/2003, pluralismo religioso, diversidade, intolerância religiosa e racismo. Partindo da hipótese de que a intolerância religiosa contra pessoas ligadas às religiões afrobrasileiras constitui uma forma de racismo, este trabalho demonstra como o racismo tem assumido diferentes formas no Brasil e se manifestado através da negação da herança cultural africana representada por essas religiões. A pesquisa consistiu em uma...

  7. O guardião da Constituição: o Supremo Tribunal Federal como poder autônomo no julgamento da Lei da Ficha Limpa

    OpenAIRE

    Rossi, Luís Antônio

    2016-01-01

    A presente tese, subsumindo a decisão diante do debate entre os juristas Hans Kelsen e Carl Schmitt sobre o controle de constitucionalidade pátrio, tem o escopo de analisar o comportamento do Supremo Tribunal Federal no julgamento da constitucionalidade da Lei da Ficha Limpa. A tese, ao analisar e refletir sobre quem deve ser o guardião da Constituição , pretende demonstrar que o sistema constitucional brasileiro adotou o positivismo de Hans Kelsen, mas a amplitude da Constituição de 1988, o...

  8. The radiosensitizing effect of Ku70/80 knockdown in MCF10A cells irradiated with X-rays and p(66)+Be(40) neutrons.

    Science.gov (United States)

    Vandersickel, Veerle; Mancini, Monica; Slabbert, Jacobus; Marras, Emanuela; Thierens, Hubert; Perletti, Gianpaolo; Vral, Anne

    2010-04-27

    A better understanding of the underlying mechanisms of DNA repair after low- and high-LET radiations represents a research priority aimed at improving the outcome of clinical radiotherapy. To date however, our knowledge regarding the importance of DNA DSB repair proteins and mechanisms in the response of human cells to high-LET radiation, is far from being complete. We investigated the radiosensitizing effect after interfering with the DNA repair capacity in a human mammary epithelial cell line (MCF10A) by lentiviral-mediated RNA interference (RNAi) of the Ku70 protein, a key-element of the nonhomologous end-joining (NHEJ) pathway. Following irradiation of control and Ku-deficient cell lines with either 6 MV X-rays or p(66)+Be(40) neutrons, cellular radiosensitivity testing was performed using a crystal violet cell proliferation assay. Chromosomal radiosensitivity was evaluated using the micronucleus (MN) assay. RNAi of Ku70 caused downregulation of both the Ku70 and the Ku80 proteins. This downregulation sensitized cells to both X-rays and neutrons. Comparable dose modifying factors (DMFs) for X-rays and neutrons of 1.62 and 1.52 respectively were obtained with the cell proliferation assay, which points to the similar involvement of the Ku heterodimer in the cellular response to both types of radiation beams. After using the MN assay to evaluate chromosomal radiosensitivity, the obtained DMFs for X-ray doses of 2 and 4 Gy were 2.95 and 2.66 respectively. After neutron irradiation, the DMFs for doses of 1 and 2 Gy were 3.36 and 2.82 respectively. The fact that DMFs are in the same range for X-rays and neutrons confirms a similar importance of the NHEJ pathway and the Ku heterodimer for repairing DNA damage induced by both X-rays and p(66)+Be(40) neutrons. Interfering with the NHEJ pathway enhanced the radiosensitivity of human MCF10A cells to low-LET X-rays and high-LET neutrons, pointing to the importance of the Ku heterodimer for repairing damage induced by both

  9. Impact of Surface Soil Moisture Variations on Radar Altimetry Echoes at Ku and Ka Bands in Semi-Arid Areas

    Directory of Open Access Journals (Sweden)

    Christophe Fatras

    2018-04-01

    Full Text Available Radar altimetry provides information on the topography of the Earth surface. It is commonly used for the monitoring not only sea surface height but also ice sheets topography and inland water levels. The radar altimetry backscattering coefficient, which depends on surface roughness and water content, can be related to surface properties such as surface soil moisture content. In this study, the influence of surface soil moisture on the radar altimetry echo and backscattering coefficient is analyzed over semi-arid areas. A semi-empirical model of the soil’s complex dielectric permittivity that takes into account that small-scale roughness and large-scale topography was developed to simulate the radar echoes. It was validated using waveforms acquired at Ku and Ka-bands by ENVISAT RA-2 and SARAL AltiKa respectively over several sites in Mali. Correlation coefficients ranging from 0.66 to 0.94 at Ku-band and from 0.27 to 0.96 at Ka-band were found. The increase in surface soil moisture from 0.02 to 0.4 (i.e., the typical range of variations in semi-arid areas increase the backscattering from 10 to 15 dB between the core of the dry and the maximum of the rainy seasons.

  10. Improved foilless Ku-band transit-time oscillator for generating gigawatt level microwave with low guiding magnetic field

    Energy Technology Data Exchange (ETDEWEB)

    Ling, Junpu; He, Juntao, E-mail: hejuntao12@163.com; Zhang, Jiande; Jiang, Tao; Hu, Yi [College of Optoelectronic Science and Engineering, National University of Defense Technology, Changsha 410073 (China)

    2014-09-15

    An improved foilless Ku-band transit-time oscillator with low guiding magnetic field is proposed and investigated in this paper. With a non-uniform buncher and a coaxial TM{sub 02} mode dual-resonant reflector, this improved device can output gigawatt level Ku-band microwave with relatively compact radial dimensions. Besides the above virtue, this novel reflector also has the merits of high TEM reflectance, being more suitable for pre-modulating the electron beam and enhancing the conversion efficiency. Moreover, in order to further increase the conversion efficiency and lower the power saturation time, a depth-tunable coaxial collector and a resonant cavity located before the extractor are employed in our device. Main structure parameters of the device are optimized by particle in cell simulations. The typical simulation result is that, with a 380 kV, 8.2 kA beam guided by a magnetic field of about 0.6 T, 1.15 GW microwave pulse at 14.25 GHz is generated, yielding a conversion efficiency of about 37%.

  11. Avaliação de transparência pública em universidades federais : estudo de múltiplos casos sob a perspectiva da Lei de Acesso à Informação

    OpenAIRE

    Rodrigues, Domingos da Costa

    2017-01-01

    Desde o ano de 2011, com o estabelecimento da Lei nº 12.527, o Estado brasileiro trabalha para estabelecer, na cultura organizacional das instituições públicas, um novo marco regulatório sobre o acesso às informações públicas, ou seja, efetivar um paradigma onde o foco do Estado seja a transparência dos atos públicos. É também conhecida como Lei da Transparência ou Lei de Acesso à Informação (LAI). Essa nova obrigação das entidades governamentais cria uma mola impulsora no sentido de uma muda...

  12. GÊNERO E CONQUISTAS: LEI MARIA DA PENHA E O ATENDIMENTO ÁS VÍTIMAS DE VIOLÊNCIA EM PALMAS TO NO ANO DE 2008

    OpenAIRE

    Czapski, Alessandra Ruita Santos

    2010-01-01

    Gênero e Conquistas: Lei Maria da Penha e o atendimento às vítimas de violência em Palmas T0 no ano de 2008 tem por objetivo a análise da aplicabilidade da lei Maria da Penha nº 11..340/06, e sua contribuição para o atendimento e amparo das vítimas de violência doméstica na cidade de Palmas. A Lei Maria da Penha sancionada pelo Presidente da República em 7 de agosto de 2006, é um instrumento jurídico importante no combate a violência doméstica praticada contra mulheres. Essa ...

  13. A Irresponsabilidade da Administração Pública por Encargos Trabalhistas em Face do Inadimplemento de Pessoa Contratada: Constitucionalidade do Art. 71, § 1º, da Lei 8.666/1993.

    Directory of Open Access Journals (Sweden)

    Adriano Figueredo Carneiro

    2011-06-01

    Full Text Available O processo licitatório é o meio pelo qual a Administração Pública, em regra, contrata pessoas para a realização de obras, serviços, compras, alienações e locações, e tem seu fundamento no art. 37, XXI, da Constituição Federal de 1988, de maneira que o contrato realizado sob o manto da Lei nº 8.666/93 (Lei de Licitações e Contratos será regido, em sua plenitude, pelas normas ali insculpidas, em face do critério da legalidade e da especialidade. A ordem jurídica licitatória e contratual excluiu a responsabilidade da Administração Pública pelos encargos trabalhistas, fiscais e comerciais resultantes da inadimplência do contratado, nos termos do art. 71, § 1º, da Lei nº 8.666/93, porém a Justiça Trabalhista, com fundamento no art. 2º, § 2º, da Consolidação das Leis do Trabalho (CLT e na Súmula nº 331, do Tribunal Superior do Trabalho, vem declarando a responsabilidade da Administração Pública pelos encargos trabalhistas, em flagrante desrespeito à lei que regula a espécie. Procura-se, neste resumido trabalho, assentar o entendimento da constitucionalidade do art. 71, § 1º, da Lei nº 8.666/93, e da não aplicação da Súmula sobredita, na parte em que enuncia a responsabilidade subsidiária dos órgãos da administração pública direta e indireta, pelos encargos trabalhistas, em virtude de inadimplência da pessoa que foi contratada.

  14. Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017; Venice (Italy; October 31-November 4, 2017; Session "Perinatal Pharmacology and Anesthesia"

    Directory of Open Access Journals (Sweden)

    --- Various Authors

    2017-10-01

    Full Text Available Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017; Venice (Italy; October 31-November 4, 201758th ESPR Annual Meeting, 7th International Congress of UENPS, 3rd International Congress of EFCNIORGANIZING INSTITUTIONSEuropean Society for Paediatric Research (ESPR, European Society for Neonatology (ESN, Union of European Neonatal & Perinatal Societies (UENPS, European Foundation for the Care of Newborn Infants (EFCNIORGANIZING COMMITTEELuc Zimmermann (President of ESPR, Morten Breindahl (President of ESN, Manuel Sánchez Luna (President of UENPS, Silke Mader (Chairwoman of the Executive Board and Co-Founder of EFCNISCIENTIFIC COMMITTEEVirgilio P. Carnielli (Congress President Chair, Pierre Gressens (Past Scientific President, Umberto Simeoni, Manon Benders, Neil Marlow, Ola D. Saugstad, Petra Hüppi, Agnes van den HoogenSession "Perinatal Pharmacology and Anesthesia"ABS 1. UNDERSTANDING THE RELATIONSHIP BETWEEN DOPAMINE CONCENTRATION AND BLOOD PRESSURE IN NEONATES: INCUBATORS VERSUS COT • K. Kirupakaran, H. Rabe, B. PatelABS 2. IBUPROFEN PHARMACOGENETIC STUDY IN HUMAN MILK SAMPLES • V. Rigourd, C. Verstyuft, J.F. Méritet, P. Seraissol, B. De Villepin, A. Amirouche, R. SerreauABS 3. EFFECT OF POSTNATAL CORTICOSTEROID ON BROWN ADIPOSE TISSUE THERMOGENESIS IN NEONATAL RAT • Y.-S. Chang, C.-H. Lin, Y.-S. TsaiABS 4. URINARY 17-α-HYDROXY-PROGESTERONE AS A POTENTIAL MARKER OF NEONATAL PAIN • M. Brasseler, T. HoehnABS 5. PHARMACOKINETIC AND PHARMACODYNAMIC STUDIES AIMING FOR RATIONAL DRUG DOSING IN PRETERM NEONATES: THE DINO STUDY • R.B. Flint, S. Völler, R. de Groot, D. Liem, P. Andriessen, P. Degrauewe, I. Reiss, D. Burger, D. Tibboel, C.A.J. Knibbe, S.H.P. Simons and DINO Research groupABS 6. VENO-ARTERIAL EXTRACORPOREAL MEM­BRANE OXYGENATION IMPAIRS ACETYL­CHOLINE-INDUCED CONTRACTION IN NEONATAL PORCINE CORONARY ARTERIES • L. Provitera, G. Cavallaro, G. Raffaeli, I. Amodeo, S. Gulden, G. Zuanetti, V

  15. Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017; Venice (Italy; October 31-November 4, 2017; Session "Perinatal Practices"

    Directory of Open Access Journals (Sweden)

    --- Various Authors

    2017-10-01

    Full Text Available Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017; Venice (Italy; October 31-November 4, 201758th ESPR Annual Meeting, 7th International Congress of UENPS, 3rd International Congress of EFCNIORGANIZING INSTITUTIONSEuropean Society for Paediatric Research (ESPR, European Society for Neonatology (ESN, Union of European Neonatal & Perinatal Societies (UENPS, European Foundation for the Care of Newborn Infants (EFCNIORGANIZING COMMITTEELuc Zimmermann (President of ESPR, Morten Breindahl (President of ESN, Manuel Sánchez Luna (President of UENPS, Silke Mader (Chairwoman of the Executive Board and Co-Founder of EFCNISCIENTIFIC COMMITTEEVirgilio P. Carnielli (Congress President Chair, Pierre Gressens (Past Scientific President, Umberto Simeoni, Manon Benders, Neil Marlow, Ola D. Saugstad, Petra Hüppi, Agnes van den HoogenSession "Perinatal Practices"ABS 1. VACUUM EXTRACTION AND RISK OF NEONATAL COMPLICATIONS: A POPULATION-BASED COHORT STUDY • D. Rossetti, A.S. Laganà, G. Valenti, B. Chiofalo, S. Butticè, G. Sanpietro, A.M.C. Rapisarda, F. Sapia, M. Noventa, A. Vitagliano, S.G. VitaleABS 2. ELECTIVE CAESAREAN SECTION AND RES­PIRATORY MORBIDITIES IN TERM INFANTS • P. Mallya, S. GargABS 3. RISK FACTORS AND OUTCOME IN PRE­VIABLE PPROM AND CURRENT TREATMENT PRACTICE • A. van Gennip, E.E.M. Mulder, R.M. Brohet, J. van Eyck, R.A. van LingenABS 4. ASSESSMENT OF FUNCTIONAL STATUS IN PRETERM INFANTS: ONLINE SURVEY TO INFORM SCORING OF A CLINICIAN-REPORTED OUTCOMES (CLINRO TOOL • M. Turner, I. Hansen-Pupp, J. Higginson, R. Ward, M. Vanya, E. Flood, E. Schwartz, H. Doll, A. Tocoian, A. Mangili, N. Barton, S. SardaABS 5. INFANTS AND MATERNAL OUTCOME OF PREGNANCIES COMPLICATED BY H1N1 INFECTION NEEDING ECMO THERAPY: A UK ECMO CENTRE EXPERIENCE • N. Singh, J. Behrsin, F. Siddiqui, R. Porter, M. Charlton, A. Akuma, S. MittalABS 6. THE ASSOCIATION OF NEONATAL MORBIDITIES AND MORTALITY OF PRETERM INFANTS WITH

  16. NATURAL LAW, HISTORY AND POLITICS LEY NATURAL, HISTORIA Y POLÍTICA LEI NATURAL, HISTÓRIA E POLÍTICA

    Directory of Open Access Journals (Sweden)

    James Drane

    2002-01-01

    de la medicina contemporáneas. Una perspectiva católica liberal intenta mantener en juego los aspectos universales y particulares del razonamiento de la Ley NaturalA visão filosófica básica e os princípios éticos da Lei Natural Católica buscam a universalidade. O propósito da Lei Natural aspira a objetividade e universalidade e, ao mesmo tempo, permanece aberto à contínua influência da história e da política. Os princípios que repousam na base da lei positiva recebem historicamente o nome de Lei Natural. O sofrimento e a injustiça contribuem para uma visão, tanto da estrutura da existência humana como aquilo que entendemos por lei e ética humana. Quando enfrentamos uma crise cultural, a Lei Natural não olha para o passado mas sim para o futuro. Atualmente é incomum que se considere as dimensões éticas das realidades sociais tendo como referência a Lei Natural. Isto vale tanto para a Igreja quanto para o Estado. Em bioética, os princípios com origem na estrutura universal da vida humana têm que proporcionar direção e normas no âmbito das variáveis da vida e da medicina contemporânea. Uma perspectiva liberal católica tenta manter presente os aspectos universais e particulares das razões da Lei Natural

  17. O MOVIMENTO NEGRO BRASILEIRO E A LEI 10.639/03: DA CRIAÇÃO AOS DESAFIOS PARA A IMPLEMENTAÇÃO

    Directory of Open Access Journals (Sweden)

    Amilcar Pereira

    2017-04-01

    Full Text Available O objetivo deste artigo é discutir o processo de criação da Lei 10.639/2003, que tornou obrigatório no Brasil o ensino de histórias e culturas africanas e afro-brasileiras, como resultado da ação do movimento negro brasileiro, bem como refletir sobre os desafios presentes que se impõem ao processo de implementação desta legislação, a partir das perspectivas de lideranças do movimento negro brasileiro por mim entrevistadas nos últimos anos. O processo histórico que resultou na criação da referida lei é bastante longo e complexo, mas indubitavelmente teve como protagonista o movimento social negro. Uma vez criada a legislação, o passo seguinte, e ainda mais complexo, é o processo de sua implementação em um país tão desigual e diverso como o Brasil. O que dizem, nesse sentido, as lideranças do movimento negro?

  18. Políticas e leis sobre violência de gênero - reflexões críticas

    Directory of Open Access Journals (Sweden)

    Adriano Beiras

    2012-04-01

    Full Text Available Leis e políticas públicas dirigidas a assuntos relacionados à violência de gênero merecem reflexão no momento de aplicação e análise. Enquadradas em uma sociedade heterocentrista e patriarcal, sua aplicação não está isenta de dificuldades, armadilhas e lacunas. Este texto, tendo como base de análise a psicologia crítica, estudos de gênero pós-estruturalistas, teoria queer e criminologia crítica, pretende ser um convite a reflexão sobre como estas leis e políticas tem contribuído para construção e permanência de um estereótipo e antinomia homem-maltratador versus vítima-mulher. Para este fim, vemos necessária a ênfase aos processos desde onde os sujeitos produzem gênero. Nossa motivação é contribuir com ferramentas de análise que permitam abrir novas perspectivas para a intervenção jurídica e assistencial. Como reflexões conclusivas, ressaltamos a importância de liberar-se de um discurso dicotômico e linear, de estar atento a relações de poder e considerar diferenças e particularidades descentradas do normativo e de posicionamentos fixos heterocentrados.

  19. Lei da gravitação universal e os satélites: uma abordagem histórico-temática usando multimídia

    Directory of Open Access Journals (Sweden)

    Elvis Vilela Rodrigues

    2012-01-01

    Full Text Available Examina-se, neste artigo, o desenvolvimento de aulas de Física em que, usando-se uma multimídia, a Lei da Gravitação Universal é abordada de forma contextualizada a partir da História da Ciência e de um tema atual (os satélites. O objetivo foi examinar como estudantes de Ensino Médio aceitam e se envolvem nesse estudo. Usando uma abordagem metodológica qualitativa, a multimídia apresenta o que são e como funcionam os satélites artificiais, trazendo uma narrativa histórica desde as ideias de movimento do sistema planetário de Ptolomeu até as de Isaac Newton sobre o movimento dos corpos, culminando na Lei da Gravitação Universal. Entrevistas, observações de sala de aula e documentos produzidos pelos estudantes mostram que as imagens, os filmes e os textos contidos na multimídia enriquecem, de modo significativo, o conteúdo, facilitando o entendimento de conceitos da Física. A contextualização histórico-temática, por sua vez, produz maior envolvimento dos alunos no estudo da Física.

  20. Norma jurídica da LEI MARIA DA PENHA EM AÇÃO: análise pragmático-cognitiva

    Directory of Open Access Journals (Sweden)

    Fábio José Rauen

    2017-02-01

    Full Text Available Neste artigo, guiados pela noção teórica de conciliação de metas de Rauen (2014, analisamos como a norma jurídica da Lei Maria da Penha é acionada em um caso de oferecimento de representação contra um agressor e solicitação de medidas protetivas à vítima. A análise sugere que a petição inicial se organizada em torno da norma jurídica, pois a seção de fatos qualifica o representado como transgressor da norma dispositiva, a seção de direitos destaca sanções para a transgressão, e a seção de pedidos decorre destas premissas. Os dados indicam que o texto funciona como hipótese abdutiva antefactual habilitadora, ao viabilizar que o juiz faça inferências similares e defira as medidas pela força lógica da conjunção dos fatos com o texto da Lei.

  1. A Lei de Sementes brasileira e os seus impactos sobre a agrobiodiversidade e os sistemas agrícolas locais e tradicionais

    Directory of Open Access Journals (Sweden)

    Juliana Santilli

    Full Text Available O artigo faz uma análise crítica dos impactos da Lei de Sementes brasileira (10.711/2003 sobre a biodiversidade agrícola e sobre a agricultura tradicional e local. A referida lei atende, principalmente, aos interesses e necessidades do sistema 'formal' de sementes e desconsidera o importante papel dos sistemas de sementes locais e tradicionais (chamados frequentemente de 'informais', nos quais as atividades de produção, intercâmbio, melhoramento e conservação de sementes são realizadas pelos próprios agricultores por meio de suas redes sociais e segundo as normas locais. Os sistemas 'formais' de sementes estão voltados, principalmente, para as espécies agrícolas de grande valor comercial e de ampla utilização em ambientes homogêneos. Assim, não são capazes de oferecer sementes adaptadas a usos e condições locais específicas e de atender às necessidades dos agricultores tradicionais e locais, que dispõem de poucos recursos e vivem em regiões heterogêneas, ambiental e culturalmente.

  2. Da delegacia da mulher à Lei Maria da Penha: Absorção/tradução de demandas feministas pelo Estado

    Directory of Open Access Journals (Sweden)

    Cecília MacDowell Santos

    2012-10-01

    Full Text Available Este artigo examina as respostas do Estado às demandas feministas para o combate à violência doméstica contra mulheres no Brasil desde meados dos anos 1980. São identificados três momentos de mudanças institucionais que direta ou indiretamente moldam e refletem os contextos da atuação estatal: o momento da criação da primeira delegacia da mulher, em 1985; o do surgimento dos Juizados Especiais Criminais, em 1995; e o da promulgação da Lei 11.340, em 2006, conhecida como Lei Maria da Penha. Estes momentos refletem a interação entre múltiplas forças sociopolíticas, sinalizando fluxos e refluxos de políticas públicas e lutas feministas. A análise destes momentos, que pretende contribuir para as teorias feministas do Estado no contexto latino‑americano, revela diferentes formas de atuação estatal e variados graus de absorção/tradução/traição/silenciamento das demandas feministas.

  3. MEDIDAS PROTETIVAS DE URGÊNCIA E AÇÕES CRIMINAIS NA LEI MARIA DA PENHA: um diálogo necessário

    Directory of Open Access Journals (Sweden)

    Thiago Gomes Viana

    2017-06-01

    Full Text Available O presente estudo adota como principais procedimentos metodológicos a pesquisa bibliográfica e jurisprudencial, a fim de que se possa discorrer acerca da questão da natureza jurídica das medidas protetivas de urgência (MPU da Lei nº 11.340/06 (Lei Maria da Penha - LMP, notadamente no que diz respeito à sua relação com ações criminais, também pautadas nesse diploma legal. O foco é evidenciar os aspectos positivos e negativos da ausência ou não de conexão entre esses dois mecanismos. Preliminarmente, são abordados o conceito e peculiaridades caracterizadoras das MPUs; em seguida, é trabalhada a relação das MPUs com a investigação da sua natureza cível ou penal, considerando as ações criminais com base na LMP e o entendimento jurisprudencial acerca dessa relação.

  4. Privaatsuse õigusest / Meelis Leis

    Index Scriptorium Estoniae

    Leis, Meelis

    1998-01-01

    Privaatsuse kui kaitstava hüve tekkeloost, selle õiguslikust ja psühholoogilisest käsitlusest, privaatsuse õigusest kohustisõiguses, Euroopa inimõiguste ja põhivabaduste kaitse konventsioonis ning Saksa, USA ja Eesti õiguskorras

  5. Impact of tropospheric scintillation in the Ku/K bands on the communications between two LEO satellites in a radio occultation geometry

    DEFF Research Database (Denmark)

    Martini, Enrica; Freni, A.; Facheris, L.

    2006-01-01

    A theoretical analysis of the impact of clear-air tropospheric scintillation on a radio occultation link between two low Earth orbit satellites in K- and Ku-bands is presented, with particular reference to differential approaches for the measure of the total content of water vapor. The troposphere...

  6. Návrh zásobníku na sypký vápenný hydrát

    OpenAIRE

    Perna, Marek

    2009-01-01

    Tato diplomová práce řeší návrh hlubokého zásobníku na sypký vápenný hydrát pro technologická zařízení čistíren odpadních vod. Je zde proveden rozbor volby typu a konstrukce zásobníku, návrh rozměrů a pevnostní výpočet zásobníku. Je zde popsána možnost vzniku klenby při vyprazdňování a její potlačení pomocí aktivních a pasivních prvků napomáhající toku. Popis aktivních a pasivních stavů napjatosti materiálu v zásobníku. This diploma thesis is solving systems design of silo for a powdery li...

  7. Deficient Pms2, ERCC1, Ku86, CcOI in field defects during progression to colon cancer.

    Science.gov (United States)

    Nguyen, Huy; Loustaunau, Cristy; Facista, Alexander; Ramsey, Lois; Hassounah, Nadia; Taylor, Hilary; Krouse, Robert; Payne, Claire M; Tsikitis, V Liana; Goldschmid, Steve; Banerjee, Bhaskar; Perini, Rafael F; Bernstein, Carol

    2010-07-28

    In carcinogenesis, the "field defect" is recognized clinically because of the high propensity of survivors of certain cancers to develop other malignancies of the same tissue type, often in a nearby location. Such field defects have been indicated in colon cancer. The molecular abnormalities that are responsible for a field defect in the colon should be detectable at high frequency in the histologically normal tissue surrounding a colonic adenocarcinoma or surrounding an adenoma with advanced neoplasia (well on the way to a colon cancer), but at low frequency in the colonic mucosa from patients without colonic neoplasia. Using immunohistochemistry, entire crypts within 10 cm on each side of colonic adenocarcinomas or advanced colonic neoplasias were found to be frequently reduced or absent in expression for two DNA repair proteins, Pms2 and/or ERCC1. Pms2 is a dual role protein, active in DNA mismatch repair as well as needed in apoptosis of cells with excess DNA damage. ERCC1 is active in DNA nucleotide excision repair. The reduced or absent expression of both ERCC1 and Pms2 would create cells with both increased ability to survive (apoptosis resistance) and increased level of mutability. The reduced or absent expression of both ERCC1 and Pms2 is likely an early step in progression to colon cancer. DNA repair gene Ku86 (active in DNA non-homologous end joining) and Cytochrome c Oxidase Subunit I (involved in apoptosis) had each been reported to be decreased in expression in mucosal areas close to colon cancers. However, immunohistochemical evaluation of their levels of expression showed only low to modest frequencies of crypts to be deficient in their expression in a field defect surrounding colon cancer or surrounding advanced colonic neoplasia. We show, here, our method of evaluation of crypts for expression of ERCC1, Pms2, Ku86 and CcOI. We show that frequency of entire crypts deficient for Pms2 and ERCC1 is often as great as 70% to 95% in 20 cm long areas

  8. Effect of Ku80 deficiency on mutation frequencies and spectra at a LacZ reporter locus in mouse tissues and cells.

    Directory of Open Access Journals (Sweden)

    Rita A Busuttil

    Full Text Available Non-homologous end joining (NHEJ is thought to be an important mechanism for preventing the adverse effects of DNA double strand breaks (DSBs and its absence has been associated with premature aging. To investigate the effect of inactivated NHEJ on spontaneous mutation frequencies and spectra in vivo and in cultured cells, we crossed a Ku80-deficient mouse with mice harboring a lacZ-plasmid-based mutation reporter. We analyzed various organs and tissues, as well as cultured embryonic fibroblasts, for mutations at the lacZ locus. When comparing mutant with wild-type mice, we observed a significantly higher number of genome rearrangements in liver and spleen and a significantly lower number of point mutations in liver and brain. The reduced point mutation frequency was not due to a decrease in small deletion mutations thought to be a hallmark of NHEJ, but could be a consequence of increased cellular responses to unrepaired DSBs. Indeed, we found a substantial increase in persistent 53BP1 and gammaH2AX DNA damage foci in Ku80-/- as compared to wild-type liver. Treatment of cultured Ku80-deficient or wild-type embryonic fibroblasts, either proliferating or quiescent, with hydrogen peroxide or bleomycin showed no differences in the number or type of induced genome rearrangements. However, after such treatment, Ku80-deficient cells did show an increased number of persistent DNA damage foci. These results indicate that Ku80-dependent repair of DNA damage is predominantly error-free with the effect of alternative more error-prone pathways creating genome rearrangements only detectable after extended periods of time, i.e., in young adult animals. The observed premature aging likely results from a combination of increased cellular senescence and an increased load of stable, genome rearrangements.

  9. OS CAMINHOS DO DIREITO: OBSTÁCULOS, FERRAMENTAS E PROCEDIMENTOS IMPORTANTES PARA SE GARANTIR A EFETIVIDADE DA LEI

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    DÉBORA SUELEN GOMES DE SOUZA

    2012-06-01

    Full Text Available Este artigo de revisão discute o papel do Tribunal de Justiça na Bahia a fim de promover um direito constitucionalmente previsto e teoricamente garantido, o acesso à justiça. A princípio, a abordagem se faz por meio da teoria sociológica sobre o campo jurídico. Tomamos o texto literário Diante da Lei, de Franz Kafka, como fundamento para discutir a teoria de Pierre Bordieu sobre o poder simbólico e os tipos de capitais presentes no campo jurídico. A revisão bibliográfica sobre o acesso a justiça reflete sobre as exigências e as restrições que a população, especificamente a mais pobre, enfrenta para buscar a efetividade do direito. Apesar de o acesso ser, teoricamente, direito de todos, de forma a obedecer à isonomia Constitucional, o que acontece é uma seletividade decorrente daquilo que se exige de forma direta ou indireta para adentrar ao campo jurídico. Ou seja, os critérios formais e os laços estreitos da justiça com as classes mais favorecidas implica numa refinagem a respeito de quem tem poder ou não para acessar este campo. Destacam-se as peculiaridades das normas constitucionais que deveriam ser direcionadas à sociedade como um todo, através de análise das funções dos magistrados que possuem a responsabilidade para exercer, efetivar e promover essas normas, além de analisarmos criticamente a respeito das instituições que auxiliam na efetivação desses direitos. Aborda-se assim, as condições que não condizem com os parâmetros constitucionais estabelecidos pelo Estado Democrático de Direito e pelo principio da isonomia que estabelece igualdade de direito para todos os indivíduos.Palavras-chave: poder simbólico; acesso a justiça; campo jurídico; democracia ABSTRACTThis review article discusses the role of the Court in Bahia to promote a right constitutionally theoretically predicted and guaranteed access to justice. In principle, the approach is done through the sociological theory about the legal

  10. Some clastic rocks as parent rocks in beech forests of Brezovica - Južni Kučaj

    Directory of Open Access Journals (Sweden)

    Joksimović Vesna

    2003-01-01

    Full Text Available On the large forest areas, where the measures of soil quality improvement are absent or rarely undertaken, the rocks are the sources of a great number of elements in plant nutrition and one of the factors affecting the contents of some elements in plants. The aim of the study is to determine the differences in the contents of Cu, Zn, Mn, Ni, Fe, Cd, Co, Pb and Cr in the beech leaves developed in the same climate conditions, on morphologically similar terrains, composed of different types of sedimentary rocks. This paper presents the study results of the contents of the above elements in argillites, sandstones (grauwackes and microconglomerates occurring as the parent rocks in high beech forests in the region of GJ Bogovina (Brezovica Južni Kučaj and in the leaves of beech developed on these rocks.

  11. Destruction of gel sulfonated cation-exchangers of the KU-2 type under the influence of hydrogen peroxide

    Energy Technology Data Exchange (ETDEWEB)

    Roginskaya, B.S.; Zavadovskaya, A.S.; Znamenskii, Yu.P.; Paskhina, N.A.; Dobrova, E.I.

    1988-10-20

    The purpose of this work was to study the mechanism of interaction of Soviet sulfonated cation-exchangers of the KU-2 type with hydrogen peroxide. It is shown that under the influence of hydrogen peroxide sulfonated cation-exchangers begin, after a certain induction period, to lose capacity and to release destruction products into water; the length of the induction period increases with the degree of cross-linking. In a given time of contact between the resin and the solution the degree of destruction falls with increase of cross-linking. The principal product of destruction of sulfonated cation-exchangers is an aromatic sulfonic acid containing oxidized groups in the side chains.

  12. Resistance to Sri Lankan Cassava Mosaic Virus (SLCMV) in Genetically Engineered Cassava cv. KU50 through RNA Silencing

    KAUST Repository

    Ntui, Valentine Otang

    2015-04-22

    Cassava ranks fifth among the starch producing crops of the world, its annual bioethanol yield is higher than for any other crop. Cassava cultivar KU50, the most widely grown cultivar for non-food purposes is susceptible to Sri Lankan cassava mosaic virus (SLCMV). The objective of this work was to engineer resistance to SLCMV by RNA interference (RNAi) in order to increase biomass yield, an important aspect for bioethanol production. Here, we produced transgenic KU50 lines expressing dsRNA homologous to the region between the AV2 and AV1 of DNA A of SLCMV. High level expression of dsRNA of SLCMV did not induce any growth abnormality in the transgenic plants. Transgenic lines displayed high levels of resistance to SLCMV compared to the wild-type plants and no virus load could be detected in uninoculated new leaves of the infected resistant lines after PCR amplification and RT-PCR analysis. The agronomic performance of the transgenic lines was unimpaired after inoculation with the virus as the plants presented similar growth when compared to the mock inoculated control plants and revealed no apparent reduction in the amount and weight of tubers produced. We show that the resistance is correlated with post-transcriptional gene silencing because of the production of transgene specific siRNA. The results demonstrate that transgenic lines exhibited high levels of resistance to SLCMV. This resistance coupled with the desirable yield components in the transgenic lines makes them better candidates for exploitation in the production of biomass as well as bioethanol.

  13. Resistance to Sri Lankan Cassava Mosaic Virus (SLCMV) in Genetically Engineered Cassava cv. KU50 through RNA Silencing

    KAUST Repository

    Ntui, Valentine Otang; Kong, Kynet; Khan, Raham Sher; Igawa, Tomoko; Janavi, Gnanaguru Janaky; Rabindran, Ramalingam; Nakamura, Ikuo; Mii, Masahiro

    2015-01-01

    Cassava ranks fifth among the starch producing crops of the world, its annual bioethanol yield is higher than for any other crop. Cassava cultivar KU50, the most widely grown cultivar for non-food purposes is susceptible to Sri Lankan cassava mosaic virus (SLCMV). The objective of this work was to engineer resistance to SLCMV by RNA interference (RNAi) in order to increase biomass yield, an important aspect for bioethanol production. Here, we produced transgenic KU50 lines expressing dsRNA homologous to the region between the AV2 and AV1 of DNA A of SLCMV. High level expression of dsRNA of SLCMV did not induce any growth abnormality in the transgenic plants. Transgenic lines displayed high levels of resistance to SLCMV compared to the wild-type plants and no virus load could be detected in uninoculated new leaves of the infected resistant lines after PCR amplification and RT-PCR analysis. The agronomic performance of the transgenic lines was unimpaired after inoculation with the virus as the plants presented similar growth when compared to the mock inoculated control plants and revealed no apparent reduction in the amount and weight of tubers produced. We show that the resistance is correlated with post-transcriptional gene silencing because of the production of transgene specific siRNA. The results demonstrate that transgenic lines exhibited high levels of resistance to SLCMV. This resistance coupled with the desirable yield components in the transgenic lines makes them better candidates for exploitation in the production of biomass as well as bioethanol.

  14. Exposure to power frequency magnetic fields suppresses X-ray-induced apoptosis transiently in Ku80-deficient xrs5 cells

    International Nuclear Information System (INIS)

    Tian, Furong; Nakahara, Takehisa; Yoshida, Masami; Honda, Naoko; Hirose, Hideki; Miyakoshi, Junji

    2002-01-01

    In an attempt to determine whether exposure to extremely low frequency (ELF) electromagnetic fields can affect cells, Ku80-deficient cells (xrs5) and Ku80-proficient cells (CHO-K1) were exposed to ELF electromagnetic fields. Cell survival, and the levels of the apoptosis-related genes p21, p53, phospho-p53 (Ser 15 ), caspase-3 and the anti-apoptosis gene bcl-2 were determined in xrs5 and CHO-K1 cells following exposure to ELF electromagnetic fields and X-rays. It was found that exposure of xrs5 and CHO-K1 cells to 60 Hz ELF electromagnetic fields had no effect on cell survival, cell cycle distribution and protein expression. Exposure of xrs5 cells to 60 Hz ELF electromagnetic fields for 5 h after irradiation significantly inhibited G 1 cell cycle arrest induced by X-rays (1 Gy) and resulted in elevated bcl-2 expression. A significant decrease in the induction of p53, phospho-p53, caspase-3 and p21 proteins was observed in xrs5 cells when irradiation by X-rays (8 Gy) was followed by exposure to 5 mT ELF magnetic fields. Exposure of xrs5 cells to the ELF electromagnetic fields for 10 h following irradiation significantly decreased X-ray-induced apoptosis from about 1.7% to 0.7%. However, this effect was not found in CHO-K1 cells within 24 h of irradiation by X-rays alone and by X-rays combined with ELF electromagnetic fields. Exposure of xrs5 cells to 60 Hz ELF electromagnetic fields following irradiation can affect cell cycle distribution and transiently suppress apoptosis by decreasing the levels of caspase-3, p21, p53 and phospho-p53 and by increasing bcl-2 expression

  15. Estudo dos Modos de Produção de Justiça da Lei Maria Da Penha em Santa Catarina

    Directory of Open Access Journals (Sweden)

    Regina Ingrid Bragagnolo

    2015-05-01

    Full Text Available Esse artigo objetiva descrever as práticas da justiça criminal construídas a partir da Lei 11.340/2006, Lei Maria da Penha, por juízes e juízas encarregados/as da aplicação deste dispositivo legal em uma Vara Criminal e Juizado de Violência contra a Mulher, em Santa Catarina. Trata-se de um estudo de inspiração etnográfica, que utilizou como fonte de pesquisa entrevistas com operadoras/os do direito e diários de campo, construídos a partir de observação de audiências e análise documental de processos penais. A pesquisa mostrou que as práticas rotineiras das/os operadoras/es do direito, no tratamento jurídico de casos tipificados como de “violência doméstica e familiar contra a mulher”, estavam orientadas pelos “estilos” pessoais de cada magistrado/a ao conduzir as audiências de ratificação, caracterizando formas de comunicação e interação de acordo com valores morais, marcados por diferentes concepções de gênero, família e justiça. A observação das práticas de equacionamento e julgamento evidenciou que os modos de produção de justiça estavam aliados à dimensão moral, de certa forma velada nos discursos dos/as operadores/as do direito, ao fazerem uso dos códigos legais. As posições políticas dessas/es profissionais, acerca do processo de criminalização da “violência doméstica e familiar contra a mulher”, resultaram, muitas vezes, em práticas contrárias às expectativas dos movimentos feministas com a criação da Lei Maria da Penha, mostrando a importância do debate sobre a judicialização das relações sociais no campo dos estudos de gênero.

  16. MOVIMENTO ESTUDANTIL EM BELO HORIZONTE: AÇÕES E REAÇÕES DOS ESTUDANTES AO DECRETO-LEI 477 (1969-1979

    Directory of Open Access Journals (Sweden)

    Daniele Teles de Oliveira

    2010-12-01

    Full Text Available RESUMO:Embasado em uma literatura específica sobre o movimento estudantil, a ação política dos jovens e também dos movimentos sociais, este trabalho procura discutir os meios de reação dos estudantes, em Belo Horizonte, entre os anos de 1969 e 1975, contra uma legislação específica (Lei Suplicy de Lacerda, Decreto Aragão e Decreto-Lei 477. O resgate dos mecanismos de reação do movimento estudantil permite uma análise que procura ir além da tradicional ênfase dada à luta armada, como mecanismo, por excelência, da ação dos estudantes. Desse modo, pensar as articulações e a manutenção da representatividade estudantil que construíram os meios de reação desse movimento em Belo Horizonte acrescenta novas perspectivas em relação a esse objeto. Assim, a análise da imprensa estudantil se mostrou relevante, no sentido de trazer contribuições para o entendimento da organização dos estudantes em torno de suas entidades representativas. PALAVRAS-CHAVE: Movimento Estudantil em Belo Horizonte, Decreto-Lei 477, Imprensa estudantil. ABSTRACT: Based in a specific literature about the student movement, political action of the youths and also about social movements, this essay seeks to discuss the means of students reaction, in Belo Horizonte, between the years of 1969 and 1975, against a specific legislation (Law Suplicy de Lacerda, Decree Aragão and Decree-Law 477.  Recovering student movements` mechanisms of reaction permits an analysis that seeks going beyond the traditional emphasis given to the armed resistance as the main mechanism of students action.  Of this way, thinking about the articulations and maintenance of the student representativeness, that built the means of movement’s reaction in Belo Horizonte, provides news perspectives regarding that subject.  Like this, the analysis of the student press was shown prominent, in the sense of bringing contributions for the understanding of the student’s organization

  17. Projetos de Lei do Senado Federal na área de Saúde Pública nos anos de 2011-2012: o perfil dos senadores brasileiros

    Directory of Open Access Journals (Sweden)

    Evelyn de Britto Dutra

    2013-12-01

    Full Text Available Conforme a Constituição Federal de 1988, a saúde constitui direito de todos e dever do Estado e o desenvolvimento desta questão tem mobilizado importantes debates na sociedade e no Congresso Nacional. O estudo analisou os projetos de lei na área de saúde, especificamente do Senado Federal, nas duas primeiras sessões legislativas da 54ª Legislatura, contribuindo para o desenvolvimento do Direito Sanitário. Foi descrito o perfil dos senadores propositores na área da saúde, identificando a influência da profissão, da filiação ideológico-partidária e da região de origem, além de uma análise simplificada do conteúdo material dos projetos apresentados. Trata-se de uma pesquisa descritivo-analítica, a base de dados foi secundária e consubstanciada no sítio eletrônico Observatório da Saúde no Legislativo (http://observatorio.fiocruz.br hospedado no servidor da Direb/Fiocruz. Os resultados apontaram que 46% dos senadores daquela legislatura atuaram na área de saúde, sendo mais atuantes os médicos (29%, os representantes do Nordeste (47,2% e os filiados aos partidos com orientação ideológico-partidária socialista e comunista (41,9%. A temática mais abordada nos projetos de lei do Senado foram as políticas públicas de saúde (29,4%. Nota se que houve um aumento na produção legislativa em Direito Sanitário quando comparada à dos anos anteriores, e que emergiram outras temáticas com grande expressão como, por exemplo, o controle de doenças. Podem-se justificar essas mudanças no contexto dos projetos de lei pela valorização da concepção preventiva.

  18. Uma estimativa do custo de subordinação da dívida financeira estabelecida pela atual lei de falência

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    José Roberto Securato

    2004-12-01

    Full Text Available Este trabalho tem como objetivo verificar o impacto no custo de endividamento das empresas devido à ordem de prioridade de pagamento das dívidas corporativas em caso de falência. A nova Lei de Falência em tramitação no Congresso Nacional, Projeto de Lei 4.376, define a ordem de classificação dos créditos na falência pelo artigo 83. A atual Lei de Falência estabelece que as dívidas trabalhistas, previdenciárias e tributárias possuem prioridade de pagamento às demais dívidas. Entende-se, portanto, que existe uma subordinação das dívidas contratadas junto aos bancos e investidores com relação aos passivos prioritários. Este estudo estima o custo de subordinação do passivo financeiro - empréstimos e financiamentos - aos passivos com preferência de pagamento. Primeiro, obteve-se evidência a favor do modelo de precificação, através da comparação do valor do passivo obtido pela aplicação do modelo com o valor de mercado, e finalmente, calculou-se uma média de 0,30%a.a. de custo de subordinação dos passivos financeiros.This paper studies the debt cost effect caused by the payment order when liquidating its liabilities in case of corporate bankruptcy established by the current Bankruptcy Legislation. The new Bankruptcy Legislation under discussion at the Brazilian Congress, Law project 4.376, defines the liability ranking order in case of Bankruptcy in article 86. The current Brazilian bankruptcy regulation defines that employee, social security and fiscal liabilities must be settled before other liabilities such as asset backed debt securities, suppliers and loans. Therefore, there is a subordination of financial liabilities - loans and financing contracted with banks and investors compared to those liabilities with liquidation priority. This research estimates the cost of subordination of financial liabilities. First, we applied the binomial model to estimate the present value of corporate liabilities and its

  19. A escravidão da criança negra e a Lei do Ventre Livre (1871/The slavery of black children education and Rio Branco Law (1871

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    Claudia Monteiro da Rocha Ramos

    2008-06-01

    Full Text Available RAMOS, C. M. R. A escravidão da criança negra e a Lei do Ventre Livre (1871. 215fl. 2008. Dissertação (Mestrado em Educação – Faculdade de Educação, Universidade Estadual de Campinas, Campinas, 2008.

  20. Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015; Budapest (Hungary; September 16-20, 2015; Session “Pharmacology”

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    Various Authors

    2015-09-01

    Full Text Available Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015; Budapest (Hungary; September 16-20, 2015ORGANIZING INSTITUTIONSEuropean Society for Neonatology (ESN, European Society for Paediatric Research (ESPR, Union of European Neonatal & Perinatal Societies (UENPS, European Foundation for the Care of Newborn Infants (EFCNI, with the local host of Hungarian Society of Perinatology and Obstetric Anesthesiology, Hungarian Society of Perinatology (MPT, supported by Council of International Neonatal Nurses (COINN, organizing secretariat MCA Scientific EventsPROGRAMME COMMITTEEArtúr Beke (Hungarian Society, Morten Breindahl (ESN, Giuseppe Buonocore (UENPS, Pierre Gressens (ESPR, Silke Mader (EFCNI, Manuel Sánchez Luna (UENPS, Miklós Szabó (Hungarian Society of Perinatology, Luc Zimmermann (ESPR Session “Pharmacology”ABS 1. BABY SKIN CARE PRODUCTS • P. Doro, R. Abraham, D. Agoston, J. Balog, R.Z. CsomaABS 2. MATHEMATICAL MODELING TO PREDICT IN-HOSPITAL NATURAL WEIGHT CHANGES IN TERM NEONATES • S. Kasser, M. Wilbaux, C. De Angelis, H. Rickenbacher, N. Klarer, J.N. Van Den Anker, M. Pfister, S. WellmannABS 3. IMPROVING PARENTERAL NUTRITION IN THE NEONATE – A PRACTICAL GUIDELINE • H. Reigstad, D. Moster, I. Grønlie, A. BlystadABS 4. INVOLUTION OF RETINOPATHY OF PREMATURITY AND NEURODEVELOPMENTAL OUTCOME AFTER BEVACIZUMAB TREATMENT • Y.-S. Chang, P.-N. Tsao, C.-Y. Chen, H.-C. Chou, W.-S. Hsieh, P.-T. YehABS 5. RELATIONSHIP BETWEEN ADVERSE DRUG REACTIONS AND OFF-LABEL/UNLICENSED DRUG USE IN HOSPITALISED CHILDREN. EREMI STUDY • K.A. Nguyen, Y. Mimouni, A. Lajoinie, N. Paret, S. Malik, L. El-Amrani, L. Milliat-Guittard, C. Carcel, A. Portefaix, A.M. Schott, T. Vial, B. KassaiABS 6. A SYSTEMATIC REVIEW OF OFF-LABEL AND UNLICENSED DRUGS USE AND ADVERSE DRUG REACTIONS IN HOSPITALIZED CHILDREN • N. David, K.A. Nguyen, Y. Mimouni, A. Lajoinie, S. Malik, B. KassaiABS 7. EFFICACY AND SAFETY OF PROPOFOL SEDATION

  1. Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017; Venice (Italy; October 31-November 4, 2017; Session "Neonatal Hematology and Bilirubin"

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    --- Various Authors

    2017-10-01

    Full Text Available Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017; Venice (Italy; October 31-November 4, 201758th ESPR Annual Meeting, 7th International Congress of UENPS, 3rd International Congress of EFCNIORGANIZING INSTITUTIONSEuropean Society for Paediatric Research (ESPR, European Society for Neonatology (ESN, Union of European Neonatal & Perinatal Societies (UENPS, European Foundation for the Care of Newborn Infants (EFCNIORGANIZING COMMITTEELuc Zimmermann (President of ESPR, Morten Breindahl (President of ESN, Manuel Sánchez Luna (President of UENPS, Silke Mader (Chairwoman of the Executive Board and Co-Founder of EFCNISCIENTIFIC COMMITTEEVirgilio P. Carnielli (Congress President Chair, Pierre Gressens (Past Scientific President, Umberto Simeoni, Manon Benders, Neil Marlow, Ola D. Saugstad, Petra Hüppi, Agnes van den HoogenSession "Neonatal Hematology and Bilirubin"ABS 1. PROLONGED JAUNDICE SCREENING: FULL BLOOD COUNT (FBC OR NO FBC! • N. Storring, R. Doherty, V. PonnusamyABS 2. EFFECT OF PROBIOTIC SUPPLEMENTATION ON BREAST MILK JAUNDICE • N. Koksal, O. Bagcı, H. Ozkan, I. Varal, P. DoganABS 3. LABORATORY FINDINGS, DIAGNOSIS AND TREATMENT OF THE NEWBORN ADMITTED DUE TO HEMATEMESIS OR BLOODY STOOL IN 11 YEARS • I. Hokuto, Y. Ito, T. Mori, S. KomachiABS 4. AN UNUSUAL CAUSE OF CYANOSIS: SEVERE METHEMOGLOBINEMIA IN A PRETERM INFANT WITH SEPSIS • F. Bakar, M. BerberABS 5. THE INFLUENCE OF INTRAUTERINE TRANSFUSION ON THE OUTCOMES OF NEWBORNS WITH SEVERE HEMOLYTIC DISEASE • E. Balashova, O. Bystrykh, T. Fedorova, O. Ionov, A. Kirtbaya, D. Sharafutdinova, V. Zubkov, D. Degtyarev, O. Horoshkeeva, N. Fedorova, N. Tetruashvili, K. Kostukov, N. KaretnikovaABS 6. PATCHED SKIN BILIRUBIN ASSAY TO MONITOR EXTREMELY PRETERM NEONATES UNDERGOING PHOTOTHERAPY • D. De Luca, V. Dell’OrtoABS 7. A PRETERM MODEL OF HYPERBILIRUBINEMIA-INDUCED CEREBELLAR DYSFUNCTION • C.F. Bearer, M. He, J.F. Watchko, J.M. Simard, N. Tang

  2. Violência e cidadania a recepção do programa chumbo grosso junto ao jovem em conflito com a lei

    OpenAIRE

    Simão, Núbia da Cunha

    2012-01-01

    A presente dissertação busca estudar como se dá a recepção de informações e imagens de violência, transmitidas cotidianamente no programa Chumbo Grosso, junto ao jovem em conflito com a lei. Para tanto faz-se uma análise das origens e do conceito de violência, buscando problematizar a apropriação midiática da violência. De modo a explicar o abuso do uso de imagens e informações de violência pela mídia busca-se fazer uma retomada das consequências da globalização para a comun...

  3. ADOLESCENTES EM CONFLITO COM A LEI EM MOÇAMBIQUE: REFLEXÕES SOBRE MEDIDAS SOCIOEDUCATIVAS E LIMITES PARA SUA APLICAÇÃO PRÁTICA.

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    Tomás Xavier Francisco

    2015-03-01

    Full Text Available Este artigo tem por fim analisar, por um lado, a problemática dos adolescentes em conflito com a lei em Moçambique, e por outro lado, fazer reflexões sobre as medidas socioeducativas e limites para a sua aplicação prática. O trabalho contempla uma introdução, desenvolvimento onde arrola-se considerações sobre o histórico da legislação sobre adolescentes ou menores no país, reflexões sobre medidas socioeducativas e seus limites para sua aplicação prática, e por fim, contempla considerações finais e referências bibliográficas. A metodologia usada foi estudo exploratório, recorrendo-se a pesquisa bibliográfica e análise documental.

  4. DESAFIOS À EDUCAÇÃO AMBIENTAL: algumas considerações sobre a efetividade da Lei 9.795/99

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    Luiz Eduardo Madeira

    2013-04-01

    Full Text Available Através dos desafios postos na efetivação da educação formal e não-formal a partir das perspectivas legais instituídas pela Lei 9.795/99, entram em conflito a visão tradicional e a visão critica em relação a transformação da sociedade. Nesse sentido, o presente trabalho vem a problematizar alguns elementos na legislação ambiental citada, com a finalidade de pensar algumas peculiaridades trazidas por essa política educacional de âmbito ambiental. Dessa forma, infere-se a importância de se pensar sobre as possibilidades e fragilidades contidas nessa legislação, para efetivar a educação ambiental como realidade na sociedade brasileira.

  5. ADOLESCENTES EM CONFLITO COM A LEI NO CONTEXTO DE DESIGUALDADES: UMA ANÁLISE SOBRE A COMUNICAÇÃO E O DIREITO NA SOCIEDADE

    OpenAIRE

    Azevedo, Kátia Simone; Reboucas, Gabriela Maia

    2017-01-01

    Este artigo explora o tema do adolescente em conflito com a lei a partir da relação entre os meios de comunicação e o direito em um contexto de desigualdades. Enquanto espaço hegemônico de informação e representante de um modelo de desenvolvimento a serviço do consumo e da violência, a mídia nega os direitos humanos ao promover um cenário de violações por meio do qual o sensacionalismo da notícia inviabiliza um projeto social coletivo comprometido com a formação cidadã. Do ponto de vista meto...

  6. A lei brasileira de ensino Rivadávia Corrêa (1911: paradoxo de um certo liberalismo Brazilian educational law 'Rivadavia Correa' (1911: the paradox of liberalism

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    Marlos Bessa Mendes da Rocha

    2012-09-01

    Full Text Available A lei Rivadávia é uma lei educacional emblemática. A historiografia educacional brasileira costuma tratá-la ou como excrescência de curta duração, pois somente prevaleceu até 1915, ou ainda como legítima expressão de um Estado republicano liberal tout court, sem necessidade de novas indagações, já que a natureza do Estado está dada. No entanto, ela é culminância de um processo histórico que tem o seu início de formulação na penúltima década do Império. Ali começa a se cogitar do "livre ensino" que, entre nós, assumiu o caráter de livre oferta de ensino. Pode-se dizer que a lei Rivadávia é a última expressão de uma "visão de mundo" que veio se estruturando naquelas duas décadas finais do Império. Ora, a prevalência de tal entendimento na República é justamente o registro de um entrave na constituição do moderno direito à educação, pois este requer um Estado propositor e garantidor. Assim, a lei Rivadávia é a expressão, entre as regulamentações de ensino, de um paradoxo: ela exacerba um liberalismo do "livre ensino" que justamente dificulta o surgimento histórico do direito social à educação em sentido moderno.ABSTRACT 'Rivadavia' educational law is emblematic. Brazilian educational historiography often refers to it as a short-term excrescence, since it prevailed until 1915, or yet, as a legitimate expression of a merely liberal republican State, with no need for further quest once the nature of the State has been given. However, it is the apogee of a historical process that has its conceptual beginnings in the second last decade of the Empire. "Liberal teaching" is then first conceived, which gained status among us as liberal educational offer. It is assertive to say that 'Rivadavia' law is the last expression of a "world view" which was developing in those two last decades of the Empire. The prevalence of such understanding in the Republic is precisely the indicator of a constitutional restraint

  7. A (inconstitucionalidade da redução salarial prevista pelo programa de proteção ao emprego (lei n. 13.189/2015

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    Oreonnilda de Souza

    2016-11-01

    Full Text Available O objetivo deste trabalho foi verificar a constitucionalidade da Lei n. 13.189/2015 que criou o Programa de Proteção ao Emprego, partindo dos fundamentos da valorização do trabalho humano, da dignidade humana e da efetividade dos objetivos da República. O Programa prevê a redução temporária da jornada de trabalho e do salário em até 30% às empresas que comprovarem dificuldades econômico-financeiras. O governo complementará, parcialmente, a remuneração do trabalhador com recursos do Fundo de Amparo ao Trabalhador. Pelo método dedutivo, a partir de revisão bibliográfica, verificou-se a falta de efetividade dos direitos fundamentais sociais e a precarização dos direitos trabalhistas.

  8. Racismo e violação aos direitos humanos pela internet: estudo da Lei nº 7.716/89

    OpenAIRE

    Celso Eduardo Santos de Melo

    2010-01-01

    Este trabalho tem como objeto específico o estudo da Lei nº 7.716/89, sobretudo o artigo 20, relativo às condutas tipificadas como crime de racismo quando praticadas utilizando-se como meio de publicação a Internet. Diante desse desafio, foi preciso verificar o histórico da questão das relações raciais no Brasil, bem como as previsões atuais de proteção do Estado contra as formas de discriminação racial. Em vista do meio utilizado na prática de condutas delituosas, a internet, foi necessário ...

  9. A delegacia da mulher perante as normas e leis para o enfrentamento da violência contra a mulher: um estudo de caso

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    Lídio de Souza

    2014-06-01

    Full Text Available Este estudo analisa o funcionamento de uma Delegacia Especializada no Atendimento à Mulher (Deam na cidade de Vitória (ES, considerando sua equipe de funcionários e infraestrutura. Os dados foram obtidos por meio de observações de campo e entrevistas individuais com os 14 funcionários da delegacia, analisados com base na "Norma Técnica de Padronização das Deams" e nas informações do relatório "Observe - Sobre as condições para aplicação da Lei nº 11.340/2006 (Lei Maria da Penha nas Deams". Houve coesão entre as respostas dos participantes, que destacaram: prejuízo em suas atividades decorrente da falta de funcionários; bom relacionamento entre os membros da equipe; e demanda por treinamento dos profissionais e por equipe psicossocial na Deam. Sobre a delegacia, foram feitas críticas à precariedade da estrutura física do prédio e dos equipamentos (viaturas, computadores, bem como à falta de apoio da Polícia Civil à Deam. Destaca-se a necessidade de investimentos na infraestrutura, na ampliação e qualificação da equipe, bem como na concretização da tríade prevenção/assistência/repressão, usualmente ignorada pelo Estado e órgãos responsáveis.

  10. Notas sobre a constituição do direito público na idade moderna: a doutrina das leis fundamentais

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    Airton Lisle Cerqueira Leite Seelaender

    2006-12-01

    Full Text Available A noção contemporânea de“constituição” é inaplicável ao Antigo Regime. Jáa de “lei fundamental” neste desempenhava umpapel relevante. Criado para limitar o podermonárquico, o conceito de “lei fundamental” logose revelou politicamente útil tanto para osopositores quanto para os partidários doabsolutismo. Difundindo-se rapidamente, seu usocontribuiu para a despatrimonialização das relaçõesrei/súdito e para a estatização da Coroa e do direito.Ampliando o interesse pela norma positiva e pelahistória do direito de cada país, a idéia de leifundamental também foi uma das referênciasbásicas na construção do direito público moderno,legitimando sua autonomia. A substituição da “leifundamental” pela “constituição” refletiu apassagem do Antigo Regime para o Liberalismo.Unlike the old concept of "fundamentallaw", the contemporary idea of "constitution" isnot suitable to describe the institucional life of theAncien Réginie. Even though it was created to limitmonarchical power, the concept of "fundamentallaw" could be politically used not only by theopponents ofAbsolutism, but also by its supporters.The concept spread quickly, contributing to thedevelopment of a new conception of king/subjectrelations, according to which Law and Crown begunalso to be identified with lhe "State". The idea of"fundamental law" stimulated the interest for thepositive norm and for the legal history of eachindividual country. ltgave niodern public law one ofits basic referentes and legitimated the autonomy ofpublic law itself. The substitution of the"fundamental law" by the "constitution" retlectedthe passage froco theAncien Regime to Liberalism.

  11. Análise de convergência espacial dos repasses da Lei Robin Hood Spatial convergence analysis of tax transfers from the Robin Hood Act

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    Noé Gonçalves Maranduba Júnior

    2009-12-01

    Full Text Available Alega-se que a Lei Robin Hood tem permitido uma melhor distribuição dos valores do ICMS devidos aos municípios do estado de Minas Gerais. O objetivo deste artigo é investigar se essa lei, entre os anos de 2001 e 2005, realmente foi eficaz, isto é, se, em termos relativos, municípios pobres receberam mais dessas transferências do que os municípios ricos. Para fazer isso metodologicamente, implementa-se uma análise exploratória de dados espaciais e uma análise de convergência, para verificar se as disparidades nos repasses diminuíram com o passar do tempo. Os resultados mostraram que os efeitos espaciais importaram nas análises e que não houve um efeito redistributivo dos repasses, considerando-se que o coeficiente indicador de convergência não foi significativo.One alleges that the Robin Hood Act has allowed one better distribution of the values of ICMS to municipalities of the state of Minas Gerais. The paper is aimed at verifying if the Robin Hood Act has actually revealed a redistributive effect in tax transfers to municipalities in the state over the period 2001-2005, that is, if, in relative terms, poor municipalities have received more these transfers than rich ones. In doing methodologically so, an exploratory spatial data analysis and a convergence analysis are implemented to verify if the disparities of tax redistribution have diminished over the time. The findings showed that the spatial effects were important in the analysis as well as there was no redistributive effect in the period because the convergence coefficient was not significant.

  12. Elementos da política e da teoria do Estado em De o espírito das leis de Montesquieu

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    Raquel Kritsch

    2011-02-01

    Full Text Available O objetivo deste artigo é introduzir os alunos no pensamento político de Charles-Louis de Secondat, mais conhecido como o barão de Montesquieu, a partir da teoria política e jurídica por ele desenvolvida em De o espírito das leis, obra que marcaria fortemente o pensamento jurídico bem como o desenho institucional do Estado constitucional moderno. Partindo-se das idéias fundantes de natureza e princípio das formas de governo, passando pela influência das causas físicas (ou materiais e sociais, discute-se a relação de causalidade de todos estes determinantes para aquilo que Montesquieu denomina “o espírito das leis”. Mostra-se ainda como o autor relaciona a liberdade política tanto à separação dos poderes do Estado e a um sistema de freios e contrapesos constitucionais quanto à brandura ou severidade das penas presente no sistema criminal de cada povo. Por fim, discute-se brevemente as noções de lei e direito natural no pensamento do autor.

  13. Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017; Venice (Italy; October 31-November 4, 2017; Session "Cardiac Physiology and Pathology"

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    --- Various Authors

    2017-10-01

    Full Text Available Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017; Venice (Italy; October 31-November 4, 201758th ESPR Annual Meeting, 7th International Congress of UENPS, 3rd International Congress of EFCNIORGANIZING INSTITUTIONSEuropean Society for Paediatric Research (ESPR, European Society for Neonatology (ESN, Union of European Neonatal & Perinatal Societies (UENPS, European Foundation for the Care of Newborn Infants (EFCNIORGANIZING COMMITTEELuc Zimmermann (President of ESPR, Morten Breindahl (President of ESN, Manuel Sánchez Luna (President of UENPS, Silke Mader (Chairwoman of the Executive Board and Co-Founder of EFCNISCIENTIFIC COMMITTEEVirgilio P. Carnielli (Congress President Chair, Pierre Gressens (Past Scientific President, Umberto Simeoni, Manon Benders, Neil Marlow, Ola D. Saugstad, Petra Hüppi, Agnes van den HoogenSession "Cardiac Physiology and Pathology"ABS 1. EVALUATION OF THE RELATIONSHIP BETWEEN PATENT DUCTUS ARTERIOSUS AND THE PLATELET MASS INDEX IN PRETERM INFANTS • M. Kara, İ. Caner, K.Ş. Tekgündüz, İ. Polat, H. KeskinABS 2. DIAGNOSIS OF DIGEORGE SYNDROME: THE CONTRIBUTION OF MOLECULAR GENETICS • Y. Halleb, H. Hadj-Abdallah, S. Nouri, A. Touati, M. Bellallah, J. Mathlouthi, N. Mahdhaoui, H. Sboui, A. Saad, D. H’midaABS 3. ASSOCIATION BETWEEN SIZE OF PATENT DUCTUS ARTERIOSUS AND CO-MORBIDITIES • S. Bellis, Y. SinghABS 4. EFFICACY OF MEDICAL TREATMENT IN CLOSING PATENT DUCTUS ARTERIOSUS IN ELBW INFANTS • S. Bellis, Y. SinghABS 5. ACETAMINOPHEN FOR CLOSING PDA. SHOULD IT BE A FIRST LINE THERAPEUTIC OPTION? • I. Tofé, M.D. Ruiz, M.P. Jaraba, M.V. Rodriguez, R.L. Rueda, M.D. Ordoñez, M.J. ParragaABS 6. PATENT DUCTUS ARTERIOSUS WITH HEMODYNAMIC REPERCUSSION IN VERY LOW WEIGHT PRETERM INFANTS TREATED WITH ORAL IBUPROFEN PRESENTS A HIGH RATE OF BRONCHOPULMONARY DYSPLASIA • M.M. Lourenço, E. Sacramento, F. Carmona, C. Calixto, F. Martin-Celini, G.H. Seribelli, W.A. Gonçalves-FerriABS 7

  14. Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015; Budapest (Hungary; September 16-20, 2015; Session “Epidemiology”

    Directory of Open Access Journals (Sweden)

    Various Authors

    2015-09-01

    Full Text Available Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015; Budapest (Hungary; September 16-20, 2015ORGANIZING INSTITUTIONSEuropean Society for Neonatology (ESN, European Society for Paediatric Research (ESPR, Union of European Neonatal & Perinatal Societies (UENPS, European Foundation for the Care of Newborn Infants (EFCNI, with the local host of Hungarian Society of Perinatology and Obstetric Anesthesiology, Hungarian Society of Perinatology (MPT, supported by Council of International Neonatal Nurses (COINN, organizing secretariat MCA Scientific EventsPROGRAMME COMMITTEEArtúr Beke (Hungarian Society, Morten Breindahl (ESN, Giuseppe Buonocore (UENPS, Pierre Gressens (ESPR, Silke Mader (EFCNI, Manuel Sánchez Luna (UENPS, Miklós Szabó (Hungarian Society of Perinatology, Luc Zimmermann (ESPR Session “Epidemiology”ABS 1. A PERFORMANCE INDICATOR FOR THE PROLONGATION OF GESTATIONAL AGE • N. LackABS 2. LATE PRETERM NEONATES AND CAUSES OF ADMISSION TO THE NICU • S. Arayici, G. Kadioglu Simsek, B. Say, E. Alyamac Dizdar, N. Uras, F.E. Canpolat, S.S. OguzABS 3. INCIDENCE AND OUTCOMES OF METABOLIC DISORDERS IN VERY PRETERM INFANTS • O. Dobush, D. Dobryanskyy, Z. Salabay, O. Detsyk, O. Novikova, Y. KuzminovABS 4. MATERNAL FACTORS INFLUENCE INFANT’S VITAMIN D STATUS • H. Hauta-alus, E. Holmlund-Suila, M. Enlund-Cerullo, J. Rosendahl, S. Valkama, O. Helve, H-M. Surcel, O. Mäkitie, S. Andersson, H. ViljakainenABS 5. THE HIGH PREVALENCE OF VITAMIN D DEFICIENCY IN A LARGE NUMBER OF PREGNANT WOMEN AND RELATED FACTORS IN ANKARA, TURKEY • G. Kadioglu Simsek, F. E. Canpolat, S. Arayici, G. Kanmaz Kutman, H.I. Yakut, Ö. Moraloğlu, B. ÖzkanABS 6. SNAPPE-II: A VALUABLE PREDICTOR OF ADVERSE OUTCOMES IN PREMATURITY • P. Costa-Reis, R. Monteiro, M. Abrantes, P. Costa, A. Graça, C. MonizABS 7. THE ASSOCIATION BETWEEN MATERNAL AND FETAL 25OHD AND INFANT SIZE AND ADIPOSITY AT BIRTH, 6 MONTHS AND 2 YEARS OF AGE • M

  15. Isolation and characterization of cDNA encoding the 80-kDa subunit protein of the human autoantigen Ku (p70/p80) recognized by autoantibodies from patients with scleroderma-polymyositis overlap syndrome

    International Nuclear Information System (INIS)

    Mimori, Tsuneyo; Ohosone, Yasuo; Hama, Nobuaki; Suwa, Akira; Akizuki, Masashi; Homma, Mitsuo; Griffith, A.J.; Hardin, J.A.

    1990-01-01

    Anti-Ku (p70/p80) autoantibodies in patients with scleroderma-polymyositis overlap syndrome recognize a 70-kDa/80-kDa protein heterodimer which binds to terminal regions of double-stranded DNA. In the present study, the authors isolated full-length cDNAs that encode the 80-kDa Ku subunit. Initial screening of a human spleen cDNA library with anti-Ku antibodies yielded a cDNA of 1.0 kilobase (kb) (termed K71) encoding a portion of the 80-kDa Ku polypeptide (identification based on immunological criteria). In RNA blots, this cDNA hybridized with two mRNAs of 3.4 and 2.6 kb. In vitro transcription and translation experiments produced an immunoprecipitable polypeptide which comigrated with the 80-kDa Ku subunit. The Ku80-6 cDNA proved to be 3304 nucleotides in length, with an additional poly(A) tail, closely approximating the size of the larger mRNA. It contains a single long open reading frame encoding 732 amino acids. The putative polypeptide has a high content of acidic amino acids and a region with periodic repeat of leucine in every seventh position which may form the leucine zipper structure. In genomic DNA blots, probes derived from the opposite ends of cDNA Ku80-6 hybridized with several nonoverlapping restriction fragments from human leukocyte DNA, indicating that the gene encoding the 80-kDa Ku polypeptide is divided into several exons by intervening sequences

  16. Detailed modeling of local anisotropy and transverse Ku interplay regarding hysteresis loop in FeCuNbSiB nanocrystalline ribbons

    Science.gov (United States)

    Geoffroy, Olivier; Boust, Nicolas; Chazal, Hervé; Flury, Sébastien; Roudet, James

    2018-04-01

    This article focuses on the modeling of the hysteresis loop featured by Fe-Cu-Nb-Si-B nanocrystalline alloys with transverse induced anisotropy. The magnetization reversal process of a magnetic correlated volume (CV), characterized by the induced anisotropy Ku, and a deviation of the local easy magnetization direction featuring the effect of a local incoherent anisotropy Ki, is analyzed, taking account of magnetostatic interactions. Solving the equations shows that considering a unique typical kind of CV does not enable accounting for both the domain pattern and the coercivity. Actually, the classical majority CVs obeying the random anisotropy model explains well the domain pattern but considering another kind of CVs, minority, mingled with classical ones, featuring a magnitude of Ki comparable to Ku, is necessary to account for coercivity. The model has been successfully compared with experimental data.

  17. Origin of absorption peaks in reflection loss spectrum in Ku- frequency band of Co-Zr substituted strontium hexaferrites prepared using sucrose precursor

    Energy Technology Data Exchange (ETDEWEB)

    Narang, Sukhleen Bindra, E-mail: sukhleen2@yahoo.com [Department of Electronics Technology, Guru Nanak Dev University, Amritsar (India); Pubby, Kunal, E-mail: kunalpubby02@gmail.com [Department of Electronics Technology, Guru Nanak Dev University, Amritsar (India); Chawla, S.K., E-mail: sschawla118@gmail.com [Department of Chemistry, Centre for Advanced Studies-I, Guru Nanak Dev University, Amritsar (India); Kaur, Prabhjyot, E-mail: prabhjyot.2525@gmail.com [Department of Chemistry, Centre for Advanced Studies-I, Guru Nanak Dev University, Amritsar (India)

    2017-03-15

    This study presents the detailed explanation of the factors, contributing towards the absorption peaks in reflection loss spectrum of hexaferrites. Cobalt-Zirconium substituted strontium hexaferrites, synthesized using sucrose precursor sol-gel technique, were analyzed in 12.4–18 GHz frequency range. The concepts of impedance matching through quarter wavelength condition, complex thickness, dielectric phase angle and attenuation constant have been used to determine the location as well as intensity of absorption peaks. This study also demonstrates the potential application of three compositions of this series with doping content (x)==0.0, 0.6 and 0.8 as an effective microwave absorbers in Ku-frequency band. - Highlights: • EM analysis of Sr Hexaferrites in Ku-band. • Factors towards absorption peak intensity & location.

  18. A creative approach to the development of an agenda for knowledge utilization: outputs from the 11th international knowledge utilization colloquium (KU 11).

    Science.gov (United States)

    Wilkinson, Joyce E; Rycroft-Malone, Jo; Davies, Huw T O; McCormack, Brendan

    2012-12-01

    A group of researchers and practitioners interested in advancing knowledge utilization met as a colloquium in Belfast (KU 11) and used a "world café" approach to exploit the social capital and shared understanding built up over previous events to consider the research and practice agenda. We considered three key areas of relevance to knowledge use: (1) understanding the nature of research use, influence and impact; (2) blended and collaborative approaches to knowledge production and use; and (3) supporting sustainability and spread of evidence-informed innovations. The approach enabled the development of artifacts that reflected the three areas and these were analyzed using a creative hermeneutic approach. The themes that emerged and which are outlined in this commentary are not mutually exclusive. There was much overlap in the discussions and therefore of the themes, reflecting the complex nature of knowledge translation work. The agenda that has emerged from KU 11 also reflects the participatory and creative approach in which the meeting was structured and focused, and therefore emphasizes the processual, relational and contingent nature of some of the challenges we face. The past 20 years has seen an explosion in activity around understanding KU, and we have learned much about the difficulties. Whilst the agenda for the next decade may be becoming clearer, colloquia such as KU 11, using creative and engaging approaches, have a key role to play in dissecting, articulating and sharing that agenda. In this way, we also build an ever-expanding international community that is dedicated to working towards increasing the chances of success for better patient care. © 2012 Sigma Theta Tau International.

  19. Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70.

    Science.gov (United States)

    Boboila, Cristian; Jankovic, Mila; Yan, Catherine T; Wang, Jing H; Wesemann, Duane R; Zhang, Tingting; Fazeli, Alex; Feldman, Lauren; Nussenzweig, Andre; Nussenzweig, Michel; Alt, Frederick W

    2010-02-16

    Class switch recombination (CSR) in B lymphocytes is initiated by introduction of multiple DNA double-strand breaks (DSBs) into switch (S) regions that flank immunoglobulin heavy chain (IgH) constant region exons. CSR is completed by joining a DSB in the donor S mu to a DSB in a downstream acceptor S region (e.g., S gamma1) by end-joining. In normal cells, many CSR junctions are mediated by classical nonhomologous end-joining (C-NHEJ), which employs the Ku70/80 complex for DSB recognition and XRCC4/DNA ligase 4 for ligation. Alternative end-joining (A-EJ) mediates CSR, at reduced levels, in the absence of C-NHEJ, even in combined absence of Ku70 and ligase 4, demonstrating an A-EJ pathway totally distinct from C-NHEJ. Multiple DSBs are introduced into S mu during CSR, with some being rejoined or joined to each other to generate internal switch deletions (ISDs). In addition, S-region DSBs can be joined to other chromosomes to generate translocations, the level of which is increased by absence of a single C-NHEJ component (e.g., XRCC4). We asked whether ISD and S-region translocations occur in the complete absence of C-NHEJ (e.g., in Ku70/ligase 4 double-deficient B cells). We found, unexpectedly, that B-cell activation for CSR generates substantial ISD in both S mu and S gamma1 and that ISD in both is greatly increased by the absence of C-NHEJ. IgH chromosomal translocations to the c-myc oncogene also are augmented in the combined absence of Ku70 and ligase 4. We discuss the implications of these findings for A-EJ in normal and abnormal DSB repair.

  20. New uranium chalcoantimonates, RbU{sub 2}SbS{sub 8} and KU{sub 2}SbSe{sub 8}, with a polar noncentrosymmetric structure

    Energy Technology Data Exchange (ETDEWEB)

    Choi, K S; Kanatzidis, M G

    1999-09-01

    The new compounds, RbU{sub 2}SbS{sub 8} and KU{sub 2}SbSe{sub 8}, were prepared as golden-black, blocklike crystals by the polychalcogenide molten flux method. RbU{sub 2}SbS{sub 8} has a two-dimensional character with layers running perpendicular to the c-axis. The coordination geometry around the U{sup 4+} atoms is best described as a bicapped trigonal prism. The trigonal prisms share triangular faces with neighboring prisms, forming one-dimensional columns along the a-axis. The columns are then joined to construct sheets by sharing capping S atoms. Sb{sup 3+} ions are sitting at the center of a slightly distorted seesaw coordination environment (CN = 4). Rb{sup +} ions are stabilized in 8-coordinate bicapped trigonal prismatic sites. KU{sub 2}SbSe{sub 8} has essentially the same structure as RbU{sub 2}SbS{sub 8}. However, Sb{sup 3+} and K{sup +} ions appear disordered in every other layer resulting in a different unit cell. RbU{sub 2}SbS{sub 8} is a semiconductor with a band gap of 1.38 eV. The band gap of KU{sub 2}SbSe{sub 8} could not be determined precisely due to the presence of overlapping intense f-f transitions in the region (0.5--1.1 eV). The Raman spectra show the disulfide stretching vibration in RbU{sub 2}SbS{sub 8} at 479 cm{sup {minus}1} and the diselenide stretching vibration in KU{sub 2}SbSe{sub 8} at 252 cm{sup {minus}1}. Magnetic susceptibility measurements indicate the presence of U{sup 4+} centers in the compounds. The compounds do not melt below 1,000 C under vacuum.

  1. The impact of the snow cover on sea-ice thickness products retrieved by Ku-band radar altimeters

    Science.gov (United States)

    Ricker, R.; Hendricks, S.; Helm, V.; Perovich, D. K.

    2015-12-01

    Snow on sea ice is a relevant polar climate parameter related to ocean-atmospheric interactions and surface albedo. It also remains an important factor for sea-ice thickness products retrieved from Ku-band satellite radar altimeters like Envisat or CryoSat-2, which is currently on its mission and the subject of many recent studies. Such satellites sense the height of the sea-ice surface above the sea level, which is called sea-ice freeboard. By assuming hydrostatic equilibrium and that the main scattering horizon is given by the snow-ice interface, the freeboard can be transformed into sea-ice thickness. Therefore, information about the snow load on hemispherical scale is crucial. Due to the lack of sufficient satellite products, only climatological values are used in current studies. Since such values do not represent the high variability of snow distribution in the Arctic, they can be a substantial contributor to the total sea-ice thickness uncertainty budget. Secondly, recent studies suggest that the snow layer cannot be considered as homogenous, but possibly rather featuring a complex stratigraphy due to wind compaction and/or ice lenses. Therefore, the Ku-band radar signal can be scattered at internal layers, causing a shift of the main scattering horizon towards the snow surface. This alters the freeboard and thickness retrieval as the assumption that the main scattering horizon is given by the snow-ice interface is no longer valid and introduces a bias. Here, we present estimates for the impact of snow depth uncertainties and snow properties on CryoSat-2 sea-ice thickness retrievals. We therefore compare CryoSat-2 freeboard measurements with field data from ice mass-balance buoys and aircraft campaigns from the CryoSat Validation Experiment. This unique validation dataset includes airborne laser scanner and radar altimeter measurements in spring coincident to CryoSat-2 overflights, and allows us to evaluate how the main scattering horizon is altered by the

  2. Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017; Venice (Italy; October 31-November 4, 2017; Session "Circulation, Macro- and Microcirculation"

    Directory of Open Access Journals (Sweden)

    --- Various Authors

    2017-10-01

    Full Text Available Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017; Venice (Italy; October 31-November 4, 201758th ESPR Annual Meeting, 7th International Congress of UENPS, 3rd International Congress of EFCNIORGANIZING INSTITUTIONSEuropean Society for Paediatric Research (ESPR, European Society for Neonatology (ESN, Union of European Neonatal & Perinatal Societies (UENPS, European Foundation for the Care of Newborn Infants (EFCNIORGANIZING COMMITTEELuc Zimmermann (President of ESPR, Morten Breindahl (President of ESN, Manuel Sánchez Luna (President of UENPS, Silke Mader (Chairwoman of the Executive Board and Co-Founder of EFCNISCIENTIFIC COMMITTEEVirgilio P. Carnielli (Congress President Chair, Pierre Gressens (Past Scientific President, Umberto Simeoni, Manon Benders, Neil Marlow, Ola D. Saugstad, Petra Hüppi, Agnes van den HoogenSession "Circulation, Macro- and Microcirculation"ABS 1. MOLECULAR AND GENETIC MARKERS FOR PREDICTION OF RESISTANCE TO INOTROPIC THERAPY IN NEWBORNS WITH ARTERIAL HYPOTENSION • D. Kryuchko, A. Donnikov, E. Baibarina, I. Nikitina, O. Ionov, D. DegtyarevABS 2. GUT AND CEREBRAL OXYGENATION FROM BIRTH TO SIX WEEKS OF LIFE IN PRETERM INFANTS: WHAT IS NORMAL? • C. Howarth, T. Leung, J. Banerjee, J. Morris, N. AladangadyABS 3. CHANGES OF NT-PROBNP CONCENTRATION WITHIN THE FIRST WEEK OF LIFE IN PRETERM NEWBORNS WITH BIRTH WEIGHT ≤ 1,200 G • T. Talar, E. Gulczyńska, B. Cyranowicz, J. MollABS 4. RESISTANCE INDEX (RI OF ARTERIA CEREBRI ANTERIOR AND CEREBRAL OXYGENATION IN PRETERM INFANTS • N. Baik-Schneditz, B. Urlesberger, B. Schwaberger, L. Mileder, N. Höller, G. PichlerABS 5. THE INFLUENCE OF MATERNAL MEDICATION ON CLOSURE OF THE DUCTUS ARTERIOSUS IN THE PREMATURE NEWBORN • W.P. de Boode, J. van Drongelen, M.J.A. RaaymakersABS 6. INFLUENCE OF GLOBAL HYPOXIA AND REMOTE ISCHEMIC POSTCONDITIONING ON NATRIURETIC PEPTIDE EXPRESSION IN NEWBORN PIGLET HEART CHAMBERS • H. Kierkegaard, K.J. Kyng, B

  3. Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017; Venice (Italy; October 31-November 4, 2017; Session "Epidemiology and Networks"

    Directory of Open Access Journals (Sweden)

    --- Various Authors

    2017-10-01

    Full Text Available Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017; Venice (Italy; October 31-November 4, 201758th ESPR Annual Meeting, 7th International Congress of UENPS, 3rd International Congress of EFCNIORGANIZING INSTITUTIONSEuropean Society for Paediatric Research (ESPR, European Society for Neonatology (ESN, Union of European Neonatal & Perinatal Societies (UENPS, European Foundation for the Care of Newborn Infants (EFCNIORGANIZING COMMITTEELuc Zimmermann (President of ESPR, Morten Breindahl (President of ESN, Manuel Sánchez Luna (President of UENPS, Silke Mader (Chairwoman of the Executive Board and Co-Founder of EFCNISCIENTIFIC COMMITTEEVirgilio P. Carnielli (Congress President Chair, Pierre Gressens (Past Scientific President, Umberto Simeoni, Manon Benders, Neil Marlow, Ola D. Saugstad, Petra Hüppi, Agnes van den HoogenSession "Epidemiology and Networks"ABS 1. AN EVALUATION OF DOCTORS AND MEDICAL STUDENT’S KNOWLEDGE OF PAEDIATRIC VACCINATIONS IN PAKISTAN • N. NadeemABS 2. AN EVALUATION OF DOCTORS AND MEDICAL STUDENT’S ATTITUDES AND BELIEFS OF PAEDIATRIC VACCINATIONS IN PAKISTAN • N. NadeemABS 3. APPLYING DATA MINING TECHNIQUES TO PREDICT BRONCHOPULMONARY DYSPLASIA IN VERY-LOW-BIRTH-WEIGHT (VLBW INFANTS. A POPULATION-BASED STUDY • Y.J. Lin, C.H. Lin, Y.C. Lin, Y.S. Chang, C.C. Huang, K.I. TsouABS 4. IN UTERO EXPOSURE TO PERFLUOROALKYL AND POLYFLUOROALKYL SUBSTANCES AND ATTENTION AND EXECUTIVE FUNCTION IN THE OFFSPRING • C.C. Bach, Z. Liew, N.B. Matthiesen, T.B. Henriksen, B.H. Bech, E.A. Nohr, E.C. Bonefeld-Jørgensen, J. OlsenABS 5. MORTALITY, MORBIDITY AND SHORT-TERM RETINOPATHY OF PREMATURITY OUTCOMES IN EXTREME PRETERM NEONATES: A 5 YEAR STUDY • H. Jarvis, M. Sdobnikovs, J. William, F. Dean, P. SatodiaABS 6. ASSOCIATION BETWEEN MATERNAL BODY MASS INDEX IN EARLY PREGNANCY AND INCIDENCE OF CEREBRAL PALSY • S. Johansson, E. Villamor, K. Tedroff, M. Peterson, M. Neovius, G. Petersson, S

  4. Rapid Recruitment of BRCA1 to DNA Double-Strand Breaks Is Dependent on Its Association with Ku80▿ †

    Science.gov (United States)

    Wei, Leizhen; Lan, Li; Hong, Zehui; Yasui, Akira; Ishioka, Chikashi; Chiba, Natsuko

    2008-01-01

    BRCA1 is the first susceptibility gene to be linked to breast and ovarian cancers. Although mounting evidence has indicated that BRCA1 participates in DNA double-strand break (DSB) repair pathways, its precise mechanism is still unclear. Here, we analyzed the in situ response of BRCA1 at DSBs produced by laser microirradiation. The amino (N)- and carboxyl (C)-terminal fragments of BRCA1 accumulated independently at DSBs with distinct kinetics. The N-terminal BRCA1 fragment accumulated immediately after laser irradiation at DSBs and dissociated rapidly. In contrast, the C-terminal fragment of BRCA1 accumulated more slowly at DSBs but remained at the sites. Interestingly, rapid accumulation of the BRCA1 N terminus, but not the C terminus, at DSBs depended on Ku80, which functions in the nonhomologous end-joining (NHEJ) pathway, independently of BARD1, which binds to the N terminus of BRCA1. Two small regions in the N terminus of BRCA1 independently accumulated at DSBs and interacted with Ku80. Missense mutations found within the N terminus of BRCA1 in cancers significantly changed the kinetics of its accumulation at DSBs. A P142H mutant failed to associate with Ku80 and restore resistance to irradiation in BRCA1-deficient cells. These might provide a molecular basis of the involvement of BRCA1 in the NHEJ pathway of the DSB repair process. PMID:18936166

  5. Vecāku pedagoģiskās kompetences pilnveide pirmsskolas izglītības iestāde

    OpenAIRE

    Vītola, Aija

    2015-01-01

    Maģistra darba autore Aija Vītola. Maģistra darba nosaukums „Vecāku pedagoģiskās kompetences pilnveide pirmsskolas izglītības iestādē”. Maģistra darba mērķis: izpētīt vecāku pedagoģiskās kompetences pilnveides iespējas pirmsskolas izglītības iestādē. Darba zinātniski teorētisko daļu veido: 1,5 – 3 gadus vecu bērnu personības attīstības likumsakarības, problēmas, ar kurām vecāki sastopas, bērnam uzsākot gaitas pirmsskolas izglītības iestādē, kompetences jēdziens, būtība, veidi, vecāku ...

  6. Study of sea-surface slope distribution and its effect on radar backscatter based on Global Precipitation Measurement Ku-band precipitation radar measurements

    Science.gov (United States)

    Yan, Qiushuang; Zhang, Jie; Fan, Chenqing; Wang, Jing; Meng, Junmin

    2018-01-01

    The collocated normalized radar backscattering cross-section measurements from the Global Precipitation Measurement (GPM) Ku-band precipitation radar (KuPR) and the winds from the moored buoys are used to study the effect of different sea-surface slope probability density functions (PDFs), including the Gaussian PDF, the Gram-Charlier PDF, and the Liu PDF, on the geometrical optics (GO) model predictions of the radar backscatter at low incidence angles (0 deg to 18 deg) at different sea states. First, the peakedness coefficient in the Liu distribution is determined using the collocations at the normal incidence angle, and the results indicate that the peakedness coefficient is a nonlinear function of the wind speed. Then, the performance of the modified Liu distribution, i.e., Liu distribution using the obtained peakedness coefficient estimate; the Gaussian distribution; and the Gram-Charlier distribution is analyzed. The results show that the GO model predictions with the modified Liu distribution agree best with the KuPR measurements, followed by the predictions with the Gaussian distribution, while the predictions with the Gram-Charlier distribution have larger differences as the total or the slick filtered, not the radar filtered, probability density is included in the distribution. The best-performing distribution changes with incidence angle and changes with wind speed.

  7. A Ku band pulsed electron paramagnetic resonance spectrometer using an arbitrary waveform generator for quantum control experiments at millikelvin temperatures

    Energy Technology Data Exchange (ETDEWEB)

    Yap, Yung Szen, E-mail: yungszen@utm.my [Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama-cho, Toyonaka-shi, Osaka 560-8531 (Japan); Faculty of Science, Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor (Malaysia); Tabuchi, Yutaka [Research Center for Advanced Science and Technology (RCAST), The University of Tokyo, Meguro-ku, Tokyo 153-8904 (Japan); Negoro, Makoto; Kagawa, Akinori; Kitagawa, Masahiro, E-mail: kitagawa@ee.es.osaka-u.ac.jp [Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama-cho, Toyonaka-shi, Osaka 560-8531 (Japan)

    2015-06-15

    We present a 17 GHz (Ku band) arbitrary waveform pulsed electron paramagnetic resonance spectrometer for experiments down to millikelvin temperatures. The spectrometer is located at room temperature, while the resonator is placed either in a room temperature magnet or inside a cryogen-free dilution refrigerator; the operating temperature range of the dilution unit is from ca. 10 mK to 8 K. This combination provides the opportunity to perform quantum control experiments on electron spins in the pure-state regime. At 0.6 T, spin echo experiments were carried out using γ-irradiated quartz glass from 1 K to 12.3 mK. With decreasing temperatures, we observed an increase in spin echo signal intensities due to increasing spin polarizations, in accordance with theoretical predictions. Through experimental data fitting, thermal spin polarization at 100 mK was estimated to be at least 99%, which was almost pure state. Next, to demonstrate the ability to create arbitrary waveform pulses, we generate a shaped pulse by superposing three Gaussian pulses of different frequencies. The resulting pulse was able to selectively and coherently excite three different spin packets simultaneously—a useful ability for analyzing multi-spin system and for controlling a multi-qubit quantum computer. By applying this pulse to the inhomogeneously broadened sample, we obtain three well-resolved excitations at 8 K, 1 K, and 14 mK.

  8. Comparison of neutron and gamma irradiation effects on KU1 fused silica monitored by electron paramagnetic resonance

    Energy Technology Data Exchange (ETDEWEB)

    Bravo, D. [Department Fisica de Materiales, Universidad Autonoma de Madrid, E-28049 Madrid (Spain)], E-mail: david.bravo@uam.es; Lagomacini, J.C. [Department Fisica de Materiales, Universidad Autonoma de Madrid, E-28049 Madrid (Spain); Leon, M.; Martin, P. [Materiales para Fusion, CIEMAT, Avda. Complutense 22, E-28040 Madrid (Spain); Martin, A. [Department Fisica e Instalaciones, ETS Arquitectura UPM, E-28040 Madrid (Spain); Lopez, F.J. [Department Fisica de Materiales, Universidad Autonoma de Madrid, E-28049 Madrid (Spain); Ibarra, A. [Materiales para Fusion, CIEMAT, Avda. Complutense 22, E-28040 Madrid (Spain)

    2009-06-15

    Electron paramagnetic resonance (EPR) studies have been carried out on KU1 fused silica irradiated with neutrons at fluences 10{sup 21} and 10{sup 22} n/m{sup 2}, and gamma-ray doses up to 12 MGy. The effects of post-irradiation thermal annealing treatments, up to 850 deg. C, have also been investigated. Paramagnetic oxygen-related defects (POR and NBOHC) and E'-type defects have been identified and their concentration has been measured as a function of neutron fluence, gamma dose and post-irradiation annealing temperature. It is found that neutrons at the highest fluence generate a much higher concentration of defects (mainly E' and POR, both at concentrations about 5 x 10{sup 18} spins/cm{sup 3}) than gamma irradiations at the highest dose (mainly E' at a concentration about 4 x 10{sup 17} spins/cm{sup 3}). Moreover, for gamma-irradiated samples a lower treatment temperature (about 400 deg. C) is required to annihilate most of the observed defects than for neutron-irradiated ones (about 600 deg. C)

  9. Tracking- and Scintillation-Aware Channel Model for GEO Satellite to Land Mobile Terminals at Ku-Band

    Directory of Open Access Journals (Sweden)

    Ali M. Al-Saegh

    2015-01-01

    Full Text Available Recent advances in satellite to land mobile terminal services and technologies, which utilize high frequencies with directional antennas, have made the design of an appropriate model for land mobile satellite (LMS channels a necessity. This paper presents LMS channel model at Ku-band with features that enhance accuracy, comprehensiveness, and reliability. The effect of satellite tracking loss at different mobile terminal speeds is considered for directional mobile antenna systems, a reliable tropospheric scintillation model for an LMS scenario at tropical and temperate regions is presented, and finally a new quality indicator module for different modulation and coding schemes is included. The proposed extended LMS channel (ELMSC model is designed based on actual experimental measurements and can be applied to narrow- and wide-band signals at different regions and at different speeds and multichannel states. The proposed model exhibits lower root mean square error (RMSE and significant performance observation compared with the conventional model in terms of the signal fluctuations, fade depth, signal-to-noise ratio (SNR, and quality indicators accompanied for several transmission schemes.

  10. Kinetic modelling and optimisation of antimicrobial compound production by Candida pyralidae KU736785 for control of Candida guilliermondii.

    Science.gov (United States)

    Mewa-Ngongang, Maxwell; du Plessis, Heinrich W; Hutchinson, Ucrecia F; Mekuto, Lukhanyo; Ntwampe, Seteno Ko

    2017-06-01

    Biological antimicrobial compounds from yeast can be used to address the critical need for safer preservatives in food, fruit and beverages. The inhibition of Candida guilliermondii, a common fermented beverage spoilage organism, was achieved using antimicrobial compounds produced by Candida pyralidae KU736785. The antimicrobial production system was modelled and optimised using response surface methodology, with 22.5 ℃ and pH of 5.0 being the optimum conditions. A new concept for quantifying spoilage organism inhibition was developed. The inhibition activity of the antimicrobial compounds was observed to be at a maximum after 17-23 h of fermentation, with C. pyralidae concentration being between 0.40 and 1.25 × 10 9 CFU ml -1 , while its maximum specific growth rate was 0.31-0.54 h -1 . The maximum inhibitory activity was between 0.19 and 1.08 l contaminated solidified media per millilitre of antimicrobial compound used. Furthermore, the antimicrobial compound formation rate was 0.037-0.086 l VZI ml -1 ACU h -1 , respectively. The response surface methodology analysis showed that the model developed sufficiently described the antimicrobial compound formation rate 1.08 l VZI ml -1 ACU, as 1.17 l VZI ml -1 ACU, predicted under the optimum production conditions.

  11. Teplovodní výměník pro krbovou vložku

    OpenAIRE

    Kněžínek, Petr

    2012-01-01

    Diplomová práce je zaměřena na problematiku zapojení krbových kamen a krbových vložek do teplovodních vytápěcích systémů. Práce obsahuje stručný popis krbů a otopných soustav. Konkrétně se zabývá návrhem teplovodního výměníku pro krbová kamna. Poslední část práce je věnována experimentálnímu ověření provozních parametrů a vyhodnocení získaných výsledků. The diploma thesis is focused on problems connecting of fireplace with water heating systems. The thesis comprises concise description of ...

  12. ENTRE LIBERDADE E REPRESENTATIVIDADE: BREVES CONSIDERAÇÕES SOBRE A LEI N. 13.467/2017, A PROPOSTA DE AUTONOMIA DO NEGOCIADO SOBRE O LEGISLADO E O PAPEL DO JUDICIÁRIO NA ANÁLISE DOS ACORDOS E CONVENÇÕES COLETIVAS

    OpenAIRE

    Bento da Silva, Lays Caceres

    2017-01-01

    A recém-publicada Lei n. 13.467, de 13 de julho de 2017, também chamada de reforma trabalhista, tem por objetivo promover alterações na Consolidação das Leis do Trabalho (Decreto-Lei no 5.452/43) e na Lei no 6.019/74, que dispõe sobre o sistema de trabalho temporário. O referido texto, que promete maior adequação à realidade econômica brasileira e redução das matérias levadas ao judiciário, vem sofrendo críticas dos mais diversos setores, incluindo os sindicatos, o Ministéri...

  13. Alívio e tensão: um estudo sobre a interpretação e a aplicação da Lei Maria da Penha nas Delegacias de Defesa da Mulher e Distritos Policiais da Seccional de Polícia de Santo André - São Paulo

    OpenAIRE

    Marilda de Oliveira Lemos

    2010-01-01

    A violência contra a mulher constitui uma violação dos direitos humanos e das liberdades fundamentais. Em 2006, o governo brasileiro aprovou a Lei 11.340 Lei Maria da Penha - que coíbe a violência doméstica e familiar contra a mulher. Apesar do esforço que vem sendo feito por órgãos governamentais e não governamentais, a implantação da Lei Maria da Penha tem encontrado resistências. Alguns representantes do Poder Judiciário advogam a inconstitucionalidade da Lei. A interpretação e aplicabili...

  14. Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015; Budapest (Hungary; September 16-20, 2015; Session “Pulmonology”

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    Various Authors

    2015-09-01

    Full Text Available Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015; Budapest (Hungary; September 16-20, 2015ORGANIZING INSTITUTIONSEuropean Society for Neonatology (ESN, European Society for Paediatric Research (ESPR, Union of European Neonatal & Perinatal Societies (UENPS, European Foundation for the Care of Newborn Infants (EFCNI, with the local host of Hungarian Society of Perinatology and Obstetric Anesthesiology, Hungarian Society of Perinatology (MPT, supported by Council of International Neonatal Nurses (COINN, organizing secretariat MCA Scientific EventsPROGRAMME COMMITTEEArtúr Beke (Hungarian Society, Morten Breindahl (ESN, Giuseppe Buonocore (UENPS, Pierre Gressens (ESPR, Silke Mader (EFCNI, Manuel Sánchez Luna (UENPS, Miklós Szabó (Hungarian Society of Perinatology, Luc Zimmermann (ESPR Session “Pulmonology”ABS 1. URINE NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN AS A MARKER OF BRONCHOPULMONARY DYSPLASIA AND RETINOPATHY OF PREMATURITY IN PRETERM NEONATES • H. Ergin, T. Atilgan, M. Dogan, O.M.A. Ozdemir, C. YeniseyABS 2. LUNG COMPLIANCE AND LUNG ULTRASOUND DURING POSTNATAL ADAPTATION IN HEALTHY NEWBORN INFANTS • L. Süvari, L. Martelius, C. Janér, A. Kaskinen, O. Pitkänen, T. Kirjavainen, O. Helve, S. AnderssonABS 3. PRE-DISCHARGE RESPIRATORY OUTCOMES IN SMALL-FOR-GESTATIONAL-AGE AND APPROPRIATE-FOR-GESTATIONAL-AGE VERY PRETERM INFANTS • A. Matic, A. RistivojevicABS 4. THE EFFECT OF CHANGING OXYGEN SATURATION TARGET RANGE ON COMPLIANCE IN OXYGEN SATURATION TARGETING IN THE NEONATAL INTENSIVE CARE UNIT • H.A. van Zanten, S. Pauws, E.C.H. Beks, B.J. Stenson, E. Lopriore, A.B. te PasABS 5. BINASAL PRONG VERSUS NASAL MASK FOR APPLYING CPAP TO PRETERM INFANTS: RANDOMIZED CONTROLLED TRIAL • B. Say, G. Kanmaz, S.S. OguzABS 6. TRAINING AND RAISING AWARENESS IMPROVES COMPLIANCE IN OXYGEN SATURATION TARGETING IN THE NEONATAL INTENSIVE CARE UNIT • H.A. van Zanten, S. Pauws, E.C.H. Beks, B.J. Stenson, E

  15. Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015; Budapest (Hungary; September 16-20, 2015; Session “Other”

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    Various Authors

    2015-09-01

    Full Text Available Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015; Budapest (Hungary; September 16-20, 2015ORGANIZING INSTITUTIONSEuropean Society for Neonatology (ESN, European Society for Paediatric Research (ESPR, Union of European Neonatal & Perinatal Societies (UENPS, European Foundation for the Care of Newborn Infants (EFCNI, with the local host of Hungarian Society of Perinatology and Obstetric Anesthesiology, Hungarian Society of Perinatology (MPT, supported by Council of International Neonatal Nurses (COINN, organizing secretariat MCA Scientific EventsPROGRAMME COMMITTEEArtúr Beke (Hungarian Society, Morten Breindahl (ESN, Giuseppe Buonocore (UENPS, Pierre Gressens (ESPR, Silke Mader (EFCNI, Manuel Sánchez Luna (UENPS, Miklós Szabó (Hungarian Society of Perinatology, Luc Zimmermann (ESPR Session “Other”ABS 1. TELEMEDICINE IN NEONATAL HOMECARE • K.G. Holm, A. Brodsgaard, G. Zachariassen, J. ClemensenABS 2. ACCEPTABILITY OF PARENT REPORT QUESTIONNAIRES FOR ROUTINE FOLLOW-UP IN LATE/MODERATELY PRETERM INFANTS • N. Armstrong, S. Johnson, E.M. BoyleABS 3. INTERNATIONAL CARE PRACTICES AROUND AN INFANT’S DEATH IN THE NICU; A SURVEY STUDY • C.M.C. van den Berg, K. Alferink, J.M. Latour, N. Valkenburg, M. van DijkABS 4. ANXIETY AND DEPRESSION OVER TIME, IN MOTHERS OF VERY PRETERM BORN CHILDREN • M. Jeukens-Visser, M. Husson, D. Meijssen, M. Flierman, P. van Schie, K. Koldewijn, A. Wassenaer-van LeemhuisABS 5. LONGITUDINAL CHANGE OF HEALTH-RELATED QUALITY OF LIFE EXPERIENCED OVER TIME BY MOTHER WITH LATE PRETERM INFANT • L.Y. Tsai, S.C. Mu, Y.L. Chen, Y.L. Guo, P.C. ChenABS 6. RELATIONSHIP BETWEEN ANXIETY LEVELS AND CLINICAL PRACTICE SKILLS AMONG STUDENTS OF PEDIATRIC NURSING LECTURE • A.S. Kurt, F.T. Arslan, S. Özkan, R. Çelen, D.A. ÇakırABS 7. ACCURACY OF SMARTPHONES FOR REVIEWING TRANSMITTED IMAGES OF NEONATAL X-RAYS • T. Vasko, M. Westberg, J.A. Dawson, L.S. Owen, M. Thio, R. Bhatia, S. Donath

  16. A lei de responsabilidade fiscal e seus mecanismos de transparência na gestão pública: um estudo de caso na prefeitura municipal do Recife (exercícios de 2001 e 2002)

    OpenAIRE

    RODRIGUES, Vânia Pereira Cavalcanti

    2004-01-01

    Este trabalho tem como eixo central a análise dos instrumentos utilizados pelo município do Recife que contribuem para uma maior transparência à gestão pública durante os exercícios de 2001 e 2002, a partir das regras inseridos na Lei de Responsabilidade Fiscal LRF (Lei Complementar nº 101, de 04 de maio de 2000). A escolha desse município se deve ao fato de que além da gestão atual proclamar a transparência em seu governo, é o município que despende maiores recursos orçament...

  17. Política criminal e Lei Maria da Penha: o deferimento do comparecimento do agressor a programas de recuperação e reeducação como a principal medida protetiva de urgência

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    Artenira da Silva e Silva

    2017-06-01

    Full Text Available A Lei Maria da Penha possui natureza marcadamente penal. Ocorre que a punição penal estatal, entendida apenas como a determinação de prisão do agressor, nos casos de violência doméstica não encontra efetiva resposta social quanto à diminuição dos casos albergados pela lei. Busca-se a utilização da previsão legal de comparecimento do agressor a programas de recuperação e reeducação como a principal medida de urgência a ser deferida como mecanismo efetivamente capaz de diminuir a reincidência de agressores de violência de gênero.

  18. Política criminal e Lei Maria da Penha: o deferimento do comparecimento do agressor a programas de recuperação e reeducação como a principal medida protetiva de urgência

    OpenAIRE

    da Silva e Silva, Artenira; Sousa da Silva Barbosa, Gabriella

    2017-01-01

    A Lei Maria da Penha possui natureza marcadamente penal. Ocorre que a punição penal estatal, entendida apenas como a determinação de prisão do agressor, nos casos de violência doméstica não encontra efetiva resposta social quanto à diminuição dos casos albergados pela lei. Busca-se a utilização da previsão legal de comparecimento do agressor a programas de recuperação e reeducação como a principal medida de urgência a ser deferida como mecanismo efetivamente capaz de diminuir a reincidência d...

  19. A EXECUÇÃO DAS MEDIDAS DE SEGURANÇA E A LEI DA REFORMA PSIQUIÁTRICA NO BRASIL CONTEMPORÂNEO

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    Mariana de Assis Brasil e Weigert

    2015-12-01

    Full Text Available Este estudo tem como objetivo relatar a prática corrente de punir os doentes mentais no Brasil através da imposição de medidas de segurança. Após décadas de demandas por reformas no sistema de internação psiquiátrica no Brasil, a Lei Federal 10.216 foi publicada e, inspirada pelos postulados da Antipsiquiatria, define os direitos e subvenções de proteção para indivíduos com desordens mentais e proíbe a admissão de doentes mentais em asilos. Além disso define o tratamento baseado nos princípios de respeito à dignidade e à autonomia dos usuários do sistema de saúde mental. A partir da discussão realizada pela Criminologia Crítica problematizamos as medidas de segurança, observando como estão até hoje estabelecidas no ordenamento jurídico brasileiro e como se constitui essa lógica estatal que se volta ao considerado louco e infrator. A ideia é, portanto, a de problematizar os conceitos que forjam essa lógica perversa que se volta ao sujeito que não é nem considerado totalmente doente, nem considerado totalmente criminoso, mas um híbrido que mescla categorias do direito e da psiquiatria, ou aquilo que Foucault nominou de “anormais”. O que apontamos, ao final são a viabilidade e a necessidade de serem encontradas alternativas jurídicas afastadas das instituições de punição, seguindo radicalmente as orientações da Lei da Reforma Psiquiátrica. Só assim pensamos ser possível evitarem-se ao máximo os estigmas que o direito penal invariavelmente impõe à sua clientela.

  20. Os impactos na atividade de auditoria independente com a introdução da lei Sarbanes-Oxley The impacts of Sarbanes-Oxley on independent auditing

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    Adriano Gomes da Silva

    2008-12-01

    Full Text Available Sucessivos escândalos de manipulação de demonstrações financeiras das companhias abertas nos Estados Unidos da América, nos anos recentes, motivaram suas autoridades reguladoras a promulgar a Lei Sarbanes-Oxley (Sox. Essa estabeleceu um conjunto severo de regras às principais figuras envolvidas no mundo corporativo, abarcando administradores, auditores, advogados e analistas de mercado. Aos auditores independentes foram destinadas regras específicas que introduziram novidades como a criação de órgão fiscalizador da profissão (PCAOB, novas regras de independência e renovadas normas de auditoria (auditing standards. A pesquisa cobriu o objetivo principal de analisar os impactos (variáveis dependentes percebidos pelos auditores independentes com a introdução da lei estadunidense (variável independente, utilizando como ferramenta a aplicação de um questionário. A metodologia de pesquisa combina revisão bibliográfica do tema e levantamento da percepção dos impactos da Sox pelos auditores independentes. Para os pesquisados, a Sox aumentou a fiscalização sobre a profissão; agregou maior credibilidade às demonstrações financeiras, ao trabalho de auditores e contadores e contribuiu para o aumento dos honorários de auditoria.Successive scandals of manipulation of open corporations' financial statements in the United States, in recent years, motivated their regulatory authorities to enact the Sarbanes-Oxley Act ("Sox". This established a strict set of rules for the primary figures involved in the corporate world, including managers, auditors, lawyers and market analysts. Specific rules that introduced innovations, such as the creation of a supervisory body (PCAOB, new independence rules and renewed auditing standards were designed for independent auditors. The research covered the main goal of analyzing the impacts (dependent variables independent auditors perceived after the introduction of the American law (independent

  1. Impacto das estratégias de coping na resiliência de atletas de vôlei de praia de alto rendimento

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    Isabella Caroline Belem

    2014-05-01

    Estudos têm apontado que, para desenvolver um perfil resiliente, os atletas precisam enfrentar as adversidades do contexto esportivo, utilizando recursos pessoais como otimismo, competitividade, motivação, maturidade e persistência. Este estudo objetivou analisar o impacto das estratégias de coping na resiliência de atletas de vôlei de praia. Participaram 48 atletas adultos do Circuito Banco do Brasil de Vôlei de Praia. Os instrumentos utilizados foram o Inventário de Estratégias de Coping (ACSI-28 e a Escala de Resiliência de Connor-Davidson (CD-RISC. Para a análise dos dados, utilizaram-se o teste de Shapiro-Wilk, “U” de Mann-Whitney, Anova de Medidas Repetidas seguida do Post Hoc de Bonferroni, Correlação de Spearman e Regressão Linear Simples (p<0,05. Resultados: estratégias de coping que tiveram impacto na resiliência dos atletas foram o Índice de Confronto Geral (48%, “Confronto com adversidade” (33%, “Confiança e motivação” (25%, “Formulação de objetivos” (12% e “Treinabilidade” (9%; atletas convocados para a seleção brasileira apresentaram altos níveis de resiliência [Md=91,50 (84,0-94,0] e utilizam as estratégias de: “Rendimento máximo sob pressão” (Md=2,25, “Confronto com as adversidades” (Md=2,62, “Formulação de objetivos” (Md=2,75 e “Confiança e motivação” (Md=2,75. Concluiu-se que utilizar estratégias de enfrentar problemas, ter metas definidas, motivação e utilizar de concentração para as competições têm um impacto significativo no desenvolvimento do perfil resiliente de atletas de rendimento.

  2. Comportamentos de risco para a saúde entre adolescentes em conflito com a lei Health risk behavior among young offenders

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    Cláudia Alves de Sena

    2008-10-01

    Full Text Available O objetivo deste estudo foi investigar as condutas de saúde entre adolescentes em conflito com a lei, internos em instituição de atendimento sócio-educativo em município da região metropolitana do Recife, Pernambuco, Brasil. A amostra foi composta por 241 jovens do sexo masculino, de 12 a 18 anos de idade. Para a coleta de dados, utilizou-se uma versão reduzida do questionário de autopreenchimento utilizado pelo Centers for Disease Control and Prevention dos Estados Unidos, traduzido e adaptado para jovens brasileiros. Entre os jovens pesquisados, 79,7% afirmaram ter portado arma, assim como 52,7% estiveram envolvidos em briga com agressão física nos últimos 12 meses. Verificou-se que a maioria dos jovens pesquisados era usuário de tabaco (87,6% e álcool (64,7%. Grande parte dos jovens afirmou já ter experimentado algum produto inalante na vida (68,9% e ter feito uso de maconha (81,3%. A maioria dos jovens (95,4% já tinha tido relação sexual, em geral com mais de um parceiro. Os jovens em situação de conflito com a lei apresentaram vários comportamentos de risco à saúde em percentuais elevados.The objective of this study was to investigate health risk behavior among teenage offenders committed to a social-educational institution in a city in Greater Metropolitan Recife, Pernambuco State, Brazil. The sample included 241 males 12-18 years of age. Data were collected with a brief self-completed questionnaire used by the Centers for Disease Control and Prevention, translated and adapted for young Brazilians. 79.7% of subjects reported having carried a gun and 52.7% had been in fights involving physical aggression in the previous 12 months. Most of the young offenders smoked cigarettes (87.6% and consumed alcohol (64.7%. The majority reported having sniffed inhalants (68.9%, and 81.3% had smoked marijuana. The vast majority (95.4% reported being sexually initiated, most having had sex with more than one partner. Young offenders

  3. Tensiomiografia utilizada para a avaliação de jogadores de vôlei de praia de alto nível

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    David Rodríguez Ruiz

    2012-04-01

    Full Text Available OBJETIVO: Esta investigação tem por objetivo coletar dados sobre rigidez muscular, as propriedades mecânicas e contráteis dos músculos utilizando a TMG em jogadores de vôlei de praia de alto nível, assim como demonstrar a utilidade deste método para a avaliação dos músculos responsáveis pela flexão e extensão do joelho. MÉTODOS: A investigação foi conduzida com um grupo de 24 jogadores de vôlei de praia os quais participaram do Torneio Europeu Nestea - Master Espanhol realizado nas Ilhas Grâ-Canárias em maio de 2009. O método de estudo utilizado foi comparação de casos individuais de vários atletas com a finalidade de verificar a utilidade deste método em esportes. Os músculos analisados foram: vasto lateral (VL, vasto medial (ML, reto femoral (RF e bíceps femoral (BF. RESULTADOS: As informações coletadas nos certificam sobre o alto grau de utilidade deste método para avaliação da rigidez muscular e equilíbrio entre estruturas musculares de atletas. Contudo, a validade e reconstrução dos resultados estão condicionadas a um severo protocolo de avaliação. Além disso, os seguintes critérios devem ser considerados: individualidade (o perfil do atleta e especificações (características do esporte. CONCLUSÕES: A aplicação da TMG em jogadores de alto nível revela a existência de importantes diferenças dependendo de suas funções em jogo (defesa, bloqueio ou alternância entre ambas as posições, as ações técnicas, a posição em quadra (direita-esquerda e o histórico de lesões médicas.

  4. Lei Maria da Penha: novas abordagens sobre velhas propostas. Onde avançamos? = The Maria da Penha Law: new approaches on old propositions. Where did we move on?

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    Pasinato, Wânia

    2010-01-01

    Full Text Available O objetivo deste artigo é refletir sobre os obstáculos e os problemas que têm sido enfrentados para a aplicação integral da Lei 11. 340/2006, a Lei Maria da Penha. As reflexões apresentadas utilizam os dados empíricos obtidos durante a realização da pesquisa sobre “Acesso à Justiça para Mulheres em Situação de Violência. Estudo Comparativo sobre as Delegacias da Mulher na América Latina (Brasil, Equador, Peru e Nicarágua”. A pesquisa foi realizada entre 2007 e 2009, em Belo Horizonte, e teve como núcleo de investigação entrevistas em profundidade com 15 mulheres que sofreram violência nas relações conjugais e procuraram a Delegacia da Mulher para registrar a ocorrência policial. Do conjunto de resultados obtidos, foram selecionados alguns dados e algumas reflexões que ajudam a ilustrar o cotidiano da aplicação da lei naquele município. Neste texto foram tomados para análise aspectos relacionados com o papel da polícia, do judiciário e da rede de serviços especializados no atendimento a mulheres em situação de violência. O objetivo é oferecer elementos para o debate em torno da aplicação da Lei Maria da Penha e contribuir para sua implementação integral

  5. A lei contra a tortura no Brasil, a construção do conceito de “crime de lesa-humanidade” e os paradoxos da punição criminal

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    Mariana Thorstensen Possas

    2016-01-01

    Full Text Available Este artigo trata da construção e utilização da distinção entre crimes contra a humanidade e crimes ordinários para fazer referência a duas “categorias” ou “tipos” de crimes, segundo os entrevistados da pesquisa: os crimes contra a humanidade seriam aqueles que violam diretamente ou de uma maneira especialmente agressiva os direitos humanos e os crimes ordinários ou comuns seriam todos os que não agridem diretamente os direitos humanos.  O conteúdo do texto foi extraído de tese de doutorado, realizada no Canadá, na Universidade de Ottawa, cujo tema de pesquisa é a criação legislativa em matéria criminal, especificamente a criação da lei contra a tortura no Brasil (Lei nº 9.455/97. Do ponto de vista empírico, o artigo se concentra na análise das entrevistas realizadas com políticos e militantes de direitos humanos que participaram direta ou indiretamente da produção da lei.

  6. POLÍTICA NACIONAL DE RESÍDUOS SÓLIDOS, LEI 12.305/2010: ESTUDO DE CASO DO MUNICÍPIO DE UBERLÂNDIA, MINAS GERAIS

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    Eduardo Giarola

    2012-12-01

    Full Text Available A discussão sobre a destinação adequada dos resíduos sólidos se insere entre as principais preocupações mundiais. Deste modo, este artigo examina a Política Nacional de Resíduos Sólidos, Lei 12.305, de 2 de agosto de 2010, para o município de Uberlândia, Minas Gerais. Em especial analisa os seus princípios norteadores e as políticas públicas implantadas pelo Governo Municipal de Uberlândia em cumprimento a esta Lei. O município, em seus projetos ambientais apresentados, comprovou a observância parcial à lei de resíduos sólidos. Ao assim proceder, o presente artigo contribui para um adequado entendimento do instrumento e alerta para possíveis dificuldades em sua regulamentação e durante a sua implantação e execução.

  7. A LEI DA NOVA POLÍTICA NACIONAL DOS RESÍDUOS SÓLIDOS FACE AO SISTEMA DE COLETA SELETIVA DO MUNICÍPIO DE SANTA MARIA

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    Tatiéle Cardoso Monteiro

    2013-04-01

    Full Text Available Este artigo tem como objetivo fazer uma breve análise acerca de alguns dos instrumentos de inovação trazidos pela Lei 12.305/10, no que se refere ao tratamento de resíduos sólidos urbanos face ao incremento do consumo da sociedade, destacando a relevância dada à coleta seletiva e às associações de catadores, como forma de viabilizar um meio ambiente sustentável. Ainda, deter-se-á a uma análise da realidade local, tentando demonstrar de que forma tem sido implementada esta política no Município de Santa Maria, através de dados e informações obtidas diretamente com a Associação de Selecionadores de Materiais Recicláveis de Santa Maria, responsável pela realização de tal serviço. Por fim, serão analisadas algumas das dificuldades enfrentadas pelos catadores no Município de Santa Maria, levantando-se a questão sobre o estímulo e suporte, por parte da administração pública municipal, às atividades destes agentes socioambientais.

  8. Lei nº 2.880, de 4 de abril de 1963 | Decreto 4.846, de 25 de setembro de 1967

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    Marta Maria Araujo

    2018-04-01

    Full Text Available Nos governos de Aluizio Alves (1961-1966 e de Monsenhor Walfredo Gurgel (1966-1971, respectivamente, no Estado do Rio Grande do Norte, foram criados o Instituto “Padre Miguelinho” (1963 e o Colégio Estadual “Winston Churchill” (1967 na capital Natal. O Instituto “Padre Miguelinho abrangia quatro unidades educacionais: Jardim de Infância “Professor Anfilóquio Câmara”; Grupo Escolar “Professor Luís Soares”; Colégio Estadual do Alecrim e o Ginásio Industrial. O Colégio Estadual “Winston Churchill” compreendia o Ensino Médio com o 1° e 2° ciclos (ginasial e colegial. Nesta Seção de Documento da Revista Educação em Questão, o Conselho Editorial publica a Lei n° 2.880, de 4 de abril de 1963, que criou o Instituto “Padre Miguelinho e o Decreto n° 4.846, de 25 de setembro de 1967, que criou o Colégio Estadual “Winston Churchill”, para fins de estudo e pesquisa de Historiadores da Educação.

  9. Roda de Conversa entre Mulheres: Denúncias Sobrea Lei Maria Da Penha e Descrença na Justiça

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    Márcia Santana Tavares

    2015-05-01

    Full Text Available Este artigo discute os desafios para a aplicação da Lei Maria da Penha em Salvador, Bahia, a partir do depoimento de onze mulheres em situação de violência doméstica e familiar, cujas queixas e demandas sobre a rede de atendimento foram verbalizadas em uma Roda de Conversa, realizada no Conselho de Desenvolvimento da Comunidade Negra (CNDN em 5 de junho de 2012, para subsidiar a elaboração de um dossiê a ser entregue à CPMI da Violência, durante suas diligências na Bahia. As mulheres consideram o atendimento insatisfatório, tanto nas DEAMs como na Vara, no Ministério Público, no IML e até no Disque 190, uma vez que suas demandas não são atendidas. Sentem-se desprotegidas, humilhadas, desrespeitadas e reféns das situações de violência que as levam a peregrinar por estas instituições

  10. Argumentação e discurso sobre Lei Maria da Penha em acórdãos do STJ

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    Lúcia Gonçalves Freitas

    2014-06-01

    Full Text Available Neste artigo, usamos a Análise de Discurso Crítica (ADC como abordagem teórico-metodológica para analisar argumentos de ministros e ministras do Superior Tribunal de Justiça (STJ em um acórdão que afetou o entendimento jurisprudencial brasileiro sobre a Lei Maria da Penha. O principal objetivo neste trabalho é analisar como a Justiça constrói argumentos relativos à violência contra as mulheres em um órgão público notório, como o STJ, que é popularmente conhecido como "Tribunal da Cidadania" por, supostamente, garantir o exercício de vários direitos para a população brasileira. Também buscamos trazer a público diálogos conflitantes, ideologias e jogos de poder inerentes à decisão em análise.

  11. MODOS DE RACIOCÍNIO DOS ESTUDANTES QUANDO A 3 a LEI DE NEWTON INTERVÉM NO ESTUDO DO FENÔMENO DO ATRITO

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    Helena Caldas

    Full Text Available Resumo: Este trabalho investiga os modos de raciocínio de uma população variada, quer pelo seu país de origem quer pelo seu nível de ensino, em situações onde a 3â lei de Newton intervém no estudo do fenômeno do atrito sólido seco. Por meio das análises de vários questionários descrevendo situações físicas onde dois ou três corpos estão em contato, são colocadas em evidência as características destes modos de raciocínio. Ainda, uma análise de livros didáticos mostra que os estudantes encontram, na grande maioria destes, elementos que alimentam o tipo de resultados encontrados. Como decorrência do conjunto dos resultados obtidos, algumas recomendações sobre o tratamento do tema do atrito serão sugeridas, no que se relaciona especificamente com os aspectos abordados no trabalho.

  12. Uma pena de ouro para a Abolição: a lei do 13 de maio e a participação popular

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    Renata Figueiredo Moraes

    2013-12-01

    Full Text Available A abolição da escravidão no Brasil, em maio de 1888, não envolveu apenas literatos, políticos, jornalistas e a família imperial, mas também, trabalhadores, abolicionistas e moradores dos subúrbios da província do Rio de Janeiro e de locais mais afastados. A participação desses foi marcada, por exemplo, pela subscrição popular realizada nas vésperas da Abolição e apoiada por um jornal, O Paiz, no intuito de comprar a pena de ouro a ser utilizada pela princesa regente no momento da assinatura da lei. A oferta do dinheiro foi feita por meio de doações individuais ou coletivas em que se depositaram também as expectativas em torno do fim da escravidão e os sentidos de liberdade mais amplos associados à Abolição. Os outros festejos promovidos pela imprensa são fundamentais para entendermos a mediação desses sentidos feita por ela.

  13. Homens de letras e homens de leis ao serviço da monarquia portuguesa (séculos XII-XIII

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    Armando Norte

    2014-06-01

    Full Text Available Ao longo da primeira dinastia, os letrados ao serviço da Coroa portuguesa desempenharam um papel decisivo e cada vez mais importante na afirmação do poder real. Homens de leis e homens de letras serviram à casa real como oficiais, representaram os reis portugueses em atos políticos e diplomáticos e exerceram um grande leque de funções na esfera da administração central - políticas, jurídicas, médicas, económicas, administrativas. A presença desses elementos ao lado dos monarcas fez-se sentir desde a fundação do reino, logo desde o reinado de D. Afonso Henriques, coincidindo o corolário deste processo de recrutamento com a chegada de D. Afonso III ao trono, numa política continuada, de forma firme, por D. Dinis. O conjunto de eruditos recenseados junto dos reis portugueses da época fundacional constitui, nessa medida, um interessante estudo de caso para compreender, em parte, em que consistia um círculo áulico, à luz dos valores do século XII e XIII.

  14. Lei de Responsabilidade Fiscal: efeitos e consequências sobre os municípios alagoanos no período 2000-10

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    Anderson Henrique dos Santos Araújo

    2015-06-01

    Full Text Available O trabalho estuda o efeito da Lei de Responsabilidade Fiscal (LRF sobre as finanças públicas dos municípios alagoanos. Fez-se a opção de trabalhar um referencial teórico menos formalista e mais crítico em relação à instauração da nova legislação. Na metodologia, manuseamos informações e dados disponíveis pela Secretaria do Tesouro Nacional, levantando estatísticas sobre aqueles municípios. Com base em índices de desempenho e capacidade fiscal, confirmou-se, no geral, o sucesso das pretensões da LRF no período 2000-10. Os cálculos indicam que esses limites foram alcançados, mas verificou-se que não garantem equilíbrio fiscal no longo prazo. Concluímos que o conceito de responsabilidade fiscal precisa ser rediscutido e essa condição não garante aos municípios capacidade de alocação e distribuição de recursos de forma mais eficiente, no quadro de mudanças rotineiras na política econômica nacional.

  15. A ESCOLA E O ADOLESCENTE EM CONFLITO COM A LEI: DESVELANDO AS TRAMAS DE UMA DIFÍCIL RELAÇÃO

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    Eliseu de Oliveira Cunha

    2016-03-01

    Full Text Available RESUMO: O presente artigo teórico propõe-se a elencar e discutir possíveis razões da inamistosidade que, de modo geral, tem caracterizado a relação entre a escola e o adolescente em conflito com a lei no Brasil. Para tanto, empreendeu-se uma cuidadosa busca na literatura pertinente ao tema no intuito de desinvisibilizar e analisar criticamente os processos histórico-sociais dos quais essa tendência é tributária. O histórico alinhamento da escola com a cultura das classes abastadas, correlato à sua típica repulsa pelos estratos populares, revelou-se a espinha dorsal do fenômeno, uma vez que a maioria dos adolescentes em questão advém dessa classe social, sendo alvo privilegiado dos preconceitos, estigmas e estereótipos tipicamente atribuídos aos jovens de baixa renda. Para a atenuação desse quadro, a requalificação das práticas escolares para um efetivo acolhimento do adolescente mostra-se imprescindível.

  16. A violência do jovem em conflito com a lei e o laço social // Youth violence in conflict with the law and social bond

    Directory of Open Access Journals (Sweden)

    Oswaldo França Neto

    2012-06-01

    Full Text Available Tendo como referência um caso clínico, e a partir de elaborações sobre duas diferentes concepções de violência, este texto se propõe a pensar as dificuldades em se apreender o lugar que os jovens em conflito com a lei ocupam na sociedade, e os impasses de sua abordagem terapêutica. Esses impasses, mais do que um obstáculo, deveriam ser o empuxo que nos permitiria confrontar as impossibilidades envolvidas, por um viés não apenas clínico, mas também político. // Taking as reference a clinical case, and from elaborations on two different conceptions of violence, this paper proposes to consider the difficulties in understanding the place that young people in conflict with the law occupy in society, and the impasse of its therapeutic approach. These impasses, more than an obstacle, should be the force that would allow us to confront the impossibilities involved, through an inclination not only clinical, but also political.

  17. A publicidade na São Paulo antes da lei "Cidade Limpa" e Berlim: uma análise comparativa nos meandros das marcas culturais

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    Luciana Coutinho Souza

    2011-01-01

    Full Text Available Resumo: Este artigo expõe os resultados de pesquisa comparativa sobre a publicidade de rua empreendida em São Paulo antes da lei "Cidade Limpa" e Berlim. Buscou-se, inicialmente, conhecer a natureza dos signos presentes nos outdoors da cidade brasileira, os seus modos de intersemiose e a temática que predominava para, então, verificar como se constituíam os signos presentes nos outdoors da cidade alemã. Estabelecidos esses parâmetros, a análise comparativa entre os outdoors das duas cidades tem lugar. Nessa empreitada, examinamos como se estabelece a trama palavra/imagem nesses temas e, finalmente, verificamos se há ou não confluência de temáticas nos outdoors de Berlim e São Paulo capazes de delinear especificidades culturais. Palavras-chave: Propaganda de rua. Palavra/imagem. Traços culturais. Erotismo.

  18. Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015; Budapest (Hungary; September 16-20, 2015; Session “Brain & Development”

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    Various Authors

    2015-09-01

    Full Text Available Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015; Budapest (Hungary; September 16-20, 2015ORGANIZING INSTITUTIONSEuropean Society for Neonatology (ESN, European Society for Paediatric Research (ESPR, Union of European Neonatal & Perinatal Societies (UENPS, European Foundation for the Care of Newborn Infants (EFCNI, with the local host of Hungarian Society of Perinatology and Obstetric Anesthesiology, Hungarian Society of Perinatology (MPT, supported by Council of International Neonatal Nurses (COINN, organizing secretariat MCA Scientific EventsPROGRAMME COMMITTEEArtúr Beke (Hungarian Society, Morten Breindahl (ESN, Giuseppe Buonocore (UENPS, Pierre Gressens (ESPR, Silke Mader (EFCNI, Manuel Sánchez Luna (UENPS, Miklós Szabó (Hungarian Society of Perinatology, Luc Zimmermann (ESPR Session “Brain & Development”ABS 1. SEPARATE EFFECTS OF LOW PATERNAL AND MATERNAL EDUCATIONAL LEVEL ON RISK OF DEVELOPMENTAL DELAY IN 4-YEAR-OLD BOYS AND GIRLS • S. de Jong, M.R. Potijk, A.E. den Heijer, S.A. Reijneveld, A.F. Bos, J.M. KerstjensABS 2. THE ASSOCIATION BETWEEN PATERNAL EDUCATIONAL LEVEL AND DEVELOPMENTAL DELAY IN PRETERM AND TERM-BORN CHILDREN AT AGE 4 • S. de Jong, J.M. Kerstjens, A.E. den Heijer, A.F. Bos, S.A. Reijneveld, M.R. PotijkABS 3. NEUROPROTECTION BY NEURONAL OVEREXPRESSION OF THE SMALL GTPase-Ras IN HYPEROXIA-INDUCED NEONATAL BRAIN INJURY • M. Serdar, K. Kempe, J. Herz, R. Herrmann, B.S. Reinboth, R. Heumann, A. Ehrkamp, U. Felderhoff-Mueser, I. BendixABS 4. REFERENCE RANGES FOR CEREBRAL TISSUE OXYGEN INDEX (cTOI IN NEONATES DURING IMMEDIATE NEONATAL TRANSITION AFTER BIRTH • N. Baik, B. Urlesberger, B. Schwaberger, G. Schmölzer, A. Avian, L. Mileder, G. PichlerABS 4. REFERENCE RANGES FOR CEREBRAL TISSUE OXYGEN INDEX (cTOI IN NEONATES DURING IMMEDIATE NEONATAL TRANSITION AFTER BIRTH • N. Baik, B. Urlesberger, B. Schwaberger, G. Schmölzer, A. Avian, L. Mileder, G. PichlerABS 6. N

  19. High-performance 16-way Ku-band radial power combiner based on the TE01-circular waveguide mode

    Science.gov (United States)

    Montejo-Garai, José R.; Saracho-Pantoja, Irene O.; Ruiz-Cruz, Jorge A.; Rebollar, Jesús M.

    2018-03-01

    This work presents a 16-way Ku-band radial power combiner for high power and high frequency applications, using the very low loss TE01 circular waveguide mode. The accomplished design shows an excellent performance: the experimental prototype has a return loss better than 30 dB, with a balance for the amplitudes of (±0.15 dB) and (±2.5°) for the phases, in a 16.7% fractional bandwidth (2 GHz centered at 12 GHz). For obtaining these outstanding specifications, required, for instance, in high-frequency amplification or on plasma systems, a rigorous step-by-step procedure is presented. First, a high-purity mode transducer has been designed, from the TE10 mode in the rectangular waveguide to the TE01 mode in the circular waveguide, with very high attenuation (>50 dB) for the other propagating and evanescent modes in the circular waveguide. This transducer has been manufactured and measured in a back-to-back configuration, validating the design process. Second, an E-plane 16-way radial power divider has been designed, where the power is coupled from the 16 non-reduced-height radial standard waveguides into the TE01 circular waveguide mode, improving the insertion loss response and removing the usual tapered transformers of previous designs limiting the power handling. Finally, both the transducer and the divider have been assembled to make the final radial combiner. The prototype has been carefully manufactured, showing very good agreement between the measurements and the full-wave simulations.

  20. Simulation study for ground-based Ku-band microwave observations of ozone and hydroxyl in the polar middle atmosphere

    Science.gov (United States)

    Newnham, David; Clilverd, Mark; Kosch, Michael; Verronen, Pekka

    2017-04-01

    Commercial satellite TV broadcasting is possible due to remarkable advances in microwave electronics, enabling weak signals transmitted over 36,000 km from geostationary orbit to be received by inexpensive rooftop dishes. The Ku band satellite frequencies (10.70-14.25 GHz) overlap microwave emissions from ozone (O3) at 11.072 GHz and hydroxyl radical (OH) at 13.44 GHz. These important chemical species in the polar middle atmosphere respond strongly to solar variability and, at high latitudes, geomagnetic activity associated with space weather. Atmospheric model calculations predict that energetic electron precipitation (EEP) driven by magnetospheric substorms produces large changes in polar mesospheric O3 and OH. The EEP typically peaks at geomagnetic latitudes ˜65˚ (e.g. Kilpisjärvi, Finland and Syowa station, Antarctica) and evolves rapidly with time eastwards and over the geomagnetic latitude range 60˚ -80˚ (e.g. reaching Halley, Antarctica). During the substorms OH can increase by more than 1000% at 64-84 km. The substorms leave footprints of 5-55% O3 loss lasting many hours of local time, with strong altitude and seasonal dependences. An atmospheric simulation and retrieval study is performed to determine the specification and design requirements for microwave radiometers capable of measuring O3 and OH profiles from Arctic and Antarctic locations using accessible satellite TV receiver technology. The proposed observations are highly applicable to studies of EEP, atmospheric dynamics, planetaryscale circulation, chemical transport, and the representation of these processes in polar and global climate models. They would provide a lowcost, reliable alternative to increasingly sparse satellite measurements, extending long-term data records and also providing "ground truth" calibration data.

  1. Expression of Mycobacterium tuberculosis Ku and Ligase D in Escherichia coli results in RecA and RecB-independent DNA end-joining at regions of microhomology.

    Science.gov (United States)

    Malyarchuk, Svitlana; Wright, Douglas; Castore, Reneau; Klepper, Emily; Weiss, Bernard; Doherty, Aidan J; Harrison, Lynn

    2007-10-01

    Unlike Escherichia coli, Mycobacterium tuberculosis (Mt) expresses a Ku-like protein and an ATP-dependent DNA ligase that can perform non-homologous end-joining (NHEJ). We have expressed the Mt-Ku and Mt-Ligase D in E. coli using an arabinose-inducible promoter and expression vectors that integrate into specific sites in the E. coli chromosome. E. coli strains have been generated that express the Mt-Ku and Mt-Ligase D on a genetic background that is wild-type for repair, or deficient in either the RecA or RecB protein. Transformation of these strains with linearized plasmid DNA containing a 2bp overhang has demonstrated that expression of both the Mt-Ku and Mt-Ligase D is required for DNA end-joining and that loss of RecA does not prevent this double-strand break repair. Analysis of the re-joined plasmid has shown that repair is predominantly inaccurate and results in the deletion of sequences. Loss of RecB did not prevent the formation of large deletions, but did increase the amount of end-joining. Sequencing the junctions has revealed that the majority of the ligations occurred at regions of microhomology (1-4bps), eliminating one copy of the homologous sequence at the junction. The Mt-Ku and Mt-Ligase D can therefore function in E. coli to re-circularize linear plasmid.

  2. A percepção dos profissionais de Contabilidade no âmbito da Prefeitura do Município De São Paulo, de Necessidades de mudanças na Lei 4.320/64: sintomas da necessidade de mudança

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    Marília Cássia Teixeira

    2013-07-01

    Full Text Available Neste trabalho de título a percepção dos profissionais de contabilidade no âmbito da Prefeitura do Município de São Paulo, das mudanças da Lei 4.320/64 e o impacto da Lei 101/00 , buscou-se alcançar o objetivo de captar a percepção dos profissionais de contabilidade no âmbito da Prefeitura do Município de São Paulo, das mudanças da Lei 4.320/64 e o impacto da Lei 101/00 e considerado o atual estado de harmonização das práticas contábeis do setor público. Neste contexto investigou-se a seguinte questão de pesquisa:  Existe a necessidade de mudança na Lei 4320/64, na percepção dos técnicos, gestores e auditores do Tribunal de Contas do Município de São Paulo?  A pesquisa foi realizada através da aplicação de um questionário a vinte e um profissionais de Contabilidade, do município com funções de gestão, de operação e auditores do tribunal de contas. Pelas respostas obtidas verificou-se que, na percepção destes indivíduos, a Lei 4.320/64 carece de atualização. Outros aspectos como a complexidade da lei em relação ao tamanho de muitos municípios foram levantados, bem como a necessidade de uma interpretação uniforme da Lei. Os conflitos entre a Lei 4.320/64 e a Lei Complementar 101/00 são resolvidos, seguindo o que estabelece a LC 101/00, por ser mais recente. Foi colocado ainda que, na visão destes profissionais, a harmonização das práticas contábeis é inevitável também no setor público, posto o atual grau de globalização que vivemos.

  3. Serial blood donations for intrauterine transfusions of severe hemolytic disease of the newborn with the use of recombinant erythropoietin in a pregnant woman alloimmunized with anti-Ku.

    Science.gov (United States)

    Lydaki, Evaggelia; Nikoloudi, Irene; Kaminopetros, Petros; Bolonaki, Irene; Sifakis, Stavros; Kikidi, Katerina; Koumantakis, Evgenios; Foundouli, Kaliopi

    2005-11-01

    The management of a pregnant woman with the rare Ko phenotype and anti-Ku is a special challenge, because matched blood is extremely rare and the possibility of severe hemolytic disease of the newborn is high. A 30-year-old woman with rare Ko (Knull) phenotype presented at 18 weeks of gestation with positive indirect agglutination test results. She had anti-Ku due to previous blood transfusion, one pregnancy, and two abortions. During this pregnancy, anti-Ku titers ranged from 1024 to 4096. At the 26th week of gestation ultrasound showed a hydropic fetus and urgent intrauterine exchange transfusion was performed with the maternal red blood cells (RBCs). Recombinant human erythropoietin (rHu-EPO) and intravenous (IV) iron were administered to the mother to ensure an adequate supply of matched RBCs for intrauterine transfusions and possible perinatal hemorrhage. Intrauterine transfusions were repeated every 1 to 3 weeks. By 35 weeks 2 days of gestation, the mother had donated 4 units of blood, and four intrauterine transfusions had been performed. Cesarean section was then decided and a healthy male newborn was born. He was treated with phototherapy but without exchange transfusions. By the 15th day of life rHu-EPO was administrated to the newborn because of anemia. The maternal RBCs completely disappeared from the child's blood by Day 100. As shown in this case, treatment with rHu-EPO and IV Fe has effectively increased the mother's capacity to donate RBCs for autologous use and intrauterine transfusions, with no adverse effects to the mother or the child.

  4. Wpływ wysiłku fizycznego na funkcję układu oddechowego w twardzinie układowej

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    Stanisław Sierakowski

    2010-12-01

    Full Text Available Cel: Powikłania ze strony układu oddechowego stanowią główną przyczynę zgonów pacjentów z twardziną układową (TU. Tętniczenadciśnienie płucne i śródmiąższowa choroba płuc stanowią najistotniejszez nich. Pacjenci są jednak często zdiagnozowani dopierow późnym okresie choroby, dlatego też istotne jest opracowaniemetody diagnostycznej do wczesnego wykrywania tych powikłań.Celem pracy była ocena wpływu wysiłku fizycznego na zmiany parametrówoddechowych. Materiały i metody: Badania przeprowadzono wśród 32 pacjentów zezdiagnozowaną TU; 72% pacjentów miało postać ograniczoną TU,28% postać uogólnioną. Wykonywano pomiar zdolności dyfuzyjnejpłuc dla tlenku węgla (DLCO, natężonej pojemności życiowej (FVC,natężonej objętości wydechowej pierwszosekundowej (FEV1 orazcałkowitej pojemności płuc (TLC w spoczynku oraz bezpośrednio pozakończeniu wysiłku fizycznego. Wyniki: Pod wpływem wysiłku fizycznego obserwowano wzrostDLCO od 59,7% do 68,1% wartości należnej (p < 0,005. Nie stwierdzononatomiast istotnych statystycznie zmian wartości FVC, FEV1oraz TLC. Wnioski: U chorych na TU zdolność dyfuzyjna płuc dla tlenku węglapo wysiłku fizycznym uległa istotnej statystycznie poprawiew porównaniu z wartościami spoczynkowymi. Związane jest toz koniecznością zapewnienia właściwego utlenowania krwi tętniczeji wynika m.in. ze zwiększenia pojemności łożyska naczyniowego.W klinicznej interpretacji wartości DLCO należy uwzględniać opróczstężenia hemoglobiny i objętości pęcherzykowej także wpływ wysiłkuoraz związane z nim zmiany wielkości objętości rzutu serca.

  5. Cave bear (Ursus spelaeus Rosenmüller & Heinroth males' den from Velika Pećina in Duboka Near Kučevo, Eastern Serbia

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    Dimitrijević Vesna M.

    2002-01-01

    Full Text Available More a 100 years after the first research in the cave Velika pećina in Duboka near Kučevo cave bear remains were discovered in a small chamber cut off from the passable channels by a 7 m high slope. A whole skull, bones of a forearm in articulation, and other skeleton parts were laying on the cave floor encrusted in travertine cover and in some places overgrown by stalagmites. Bones belonged to adult males, which found there the shelter to hibernate, in a short epizode that ended by closing the channels that once linked this part of the cave to a surface.

  6. Regularização de passivos decorrentes das infrações ao regime de Área de Preservação Permanente na lei de proteção da vegetação nativa

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    Ana Schenkel

    2016-02-01

    Full Text Available http://dx.doi.org/10.5007/2175-7925.2016v29n1p155 Política florestal não é tema novo no Brasil; desde a época imperial leis foram produzidas tratando das florestas, incluindo os Códigos Florestal e de Águas de 1934 e o Novo Código Florestal de 1965. A versão original do Código de 1965 proibiu a supressão de vegetação em áreas sensíveis – como encostas e margens de rios. Este estudo avalia a operacionalização do Programa de Regularização Ambiental na Microrregião de Florianópolis. Foram utilizadas como referências as normas correlatas ao tema e materiais disponibilizados em sítios eletrônicos de agências governamentais e ONGs. Os dados mostram que depois de três anos de vigência da Lei 12.651/2012, muito do que é exigido não foi implementado e os prazos são ignorados pela União. Pela nova lei agricultores com terras desmatadas terão de replantá-las, o que promoverá o reflorestamento de 30 milhões de hectares, mas a nova lei continua a ser difícil de aplicar, criando expectativa de impunidade para o desmatamento futuro. A partir desta análise, conclui-se que, se não houver pressão da sociedade civil, a Lei 12.651/2012 será uma lei revogada por falta de cumprimento. Isso requer maior informação sobre a lei e o quanto a preservação do ambiente afeta a vida diária de todos.

  7. Archeologie středověkých konstrukčních technologií - sbíjená rakev s panty a kruhovými úchyty z pohřebiště při kostele sv. Klimenta ve Staré Boleslavi

    Czech Academy of Sciences Publication Activity Database

    Boháčová, Ivana; Hošek, Jiří

    2014-01-01

    Roč. 39, č. 1 (2014), s. 241-255 ISSN 0231-5823. [Mezinárodní konference archeologie středověku /45./. Kutná Hora, 16.09.2013-19.09.2013] Institutional support: RVO:67985912 Keywords : burials * coffin * construction * Middle Ages * Bohemia Subject RIV: AC - Archeology, Anthropology, Ethnology

  8. Spatial variations of community structures and methane cycling across a transect of Lei-Gong-Hou mud volcanoes in eastern Taiwan

    Directory of Open Access Journals (Sweden)

    Pei-Ling eWang

    2014-03-01

    Full Text Available This study analyzed cored sediments retrieved from sites distributed across a transect of the Lei-Gong-Hou mud volcanoes in eastern Taiwan to uncover the spatial distributions of biogeochemical processes and community assemblages involved in methane cycling. The profiles of methane concentration and carbon isotopic composition revealed various orders of the predominance of specific methane-related metabolisms along depth. At a site proximal to the bubbling pool, the methanogenic zone was sandwiched by the anaerobic methanotrophic zones. For two sites distributed toward the topographic depression, the methanogenic zone overlaid the anaerobic methanotrophic zone. The predominance of anaerobic methanotrophy at specific depth intervals is supported by the enhanced copy numbers of the ANME-2a 16S rRNA gene and coincides with high dissolved Fe/Mn concentrations and copy numbers of the Desulfuromonas/Pelobacter 16S rRNA gene. Assemblages of 16S rRNA and mcrA genes revealed that methanogenesis was mediated by Methanococcoides and Methanosarcina. pmoA genes and a few 16S rRNA genes related to aerobic methanotrophs were detected in limited numbers of subsurface samples. While dissolved Fe/Mn signifies the presence of anaerobic metabolisms near the surface, the correlations between geochemical characteristics and gene abundances, and the absence of aerobic methanotrophs in top sediments suggest that anaerobic methanotrophy is potentially dependent on iron/manganese reduction and dominates over aerobic methanotrophy for the removal of methane produced in situ or from a deep source. Near-surface methanogenesis contributes to the methane emissions from mud platform. The alternating arrangements of methanogenic and methanotrophic zones at different sites suggest that the interactions between mud deposition, evaporation, oxidation and fluid transport modulate the assemblages of microbial communities and methane cycling in different compartments of terrestrial

  9. Spatial variations of community structures and methane cycling across a transect of Lei-Gong-Hou mud volcanoes in eastern Taiwan.

    Science.gov (United States)

    Wang, Pei-Ling; Chiu, Yi-Ping; Cheng, Ting-Wen; Chang, Yung-Hsin; Tu, Wei-Xain; Lin, Li-Hung

    2014-01-01

    This study analyzed cored sediments retrieved from sites distributed across a transect of the Lei-Gong-Hou mud volcanoes in eastern Taiwan to uncover the spatial distributions of biogeochemical processes and community assemblages involved in methane cycling. The profiles of methane concentration and carbon isotopic composition revealed various orders of the predominance of specific methane-related metabolisms along depth. At a site proximal to the bubbling pool, the methanogenic zone was sandwiched by the anaerobic methanotrophic zones. For two sites distributed toward the topographic depression, the methanogenic zone overlaid the anaerobic methanotrophic zone. The predominance of anaerobic methanotrophy at specific depth intervals is supported by the enhanced copy numbers of the ANME-2a 16S rRNA gene and coincides with high dissolved Fe/Mn concentrations and copy numbers of the Desulfuromonas/Pelobacter 16S rRNA gene. Assemblages of 16S rRNA and mcrA genes revealed that methanogenesis was mediated by Methanococcoides and Methanosarcina. pmoA genes and a few 16S rRNA genes related to aerobic methanotrophs were detected in limited numbers of subsurface samples. While dissolved Fe/Mn signifies the presence of anaerobic metabolisms near the surface, the correlations between geochemical characteristics and gene abundances, and the absence of aerobic methanotrophs in top sediments suggest that anaerobic methanotrophy is potentially dependent on iron/manganese reduction and dominates over aerobic methanotrophy for the removal of methane produced in situ or from a deep source. Near-surface methanogenesis contributes to the methane emissions from mud platform. The alternating arrangements of methanogenic and methanotrophic zones at different sites suggest that the interactions between mud deposition, evaporation, oxidation and fluid transport modulate the assemblages of microbial communities and methane cycling in different compartments of terrestrial mud volcanoes.

  10. Fatores protetivos a adolescentes em conflito com a lei no contexto socioeducativo Protective factors for adolescents in conflict with the law within the social-educational context

    Directory of Open Access Journals (Sweden)

    Cláudia Regina Brandão Sampaio Fernandes da Costa

    2006-12-01

    Full Text Available O presente artigo tem por objetivo tecer considerações acerca da importância e possibilidade de promover fatores de proteção ao adolescente em conflito com a lei no contexto de aplicação de medida sócioeducativa. Tomando como referência a Doutrina da Proteção Integral - eixo central do Estatuto da Criança e do Adolescente -, o Paradigma da Promoção da Saúde e estudos sobre resiliência, postula-se a existência de alguns fatores considerados de grande relevância ao desenvolvimento dos adolescentes, visando modificar o quadro de vulnerabilidade ao qual encontram-se associados. Sugere que a ênfase nos aspectos saudáveis do desenvolvimento favorece a emergência do potencial positivo do qual todo contexto sócioeducativo deve ser revestido, a fim de possibilitar a construção de novas perspectivas aos jovens em risco social.The purpose of this article is to make certain considerations regarding the importance and possibility of promoting protection factors to adolescents in conflict with the law within the context of applying social and educational measures. Using the Integral Protection Doctrine as a doctrinal reference - the core theme of the Statute of the Child and Adolescent - and the Paradigm of Health Promotion along with studies on development and resilience, this paper postulates the existence of certain factors considered highly relevant to the development of adolescents, seeking to modify the situation of vulnerability in which they find themselves. The paper suggests that an emphasis on health aspects of development favor the emergence of a positive potential that should be included throughout the social-educational context, so as to enable the construction of new perspectives by socially at risk youth.

  11. Prokaryotic Homologs of the Eukaryotic 3-Hydroxyanthranilate 3,4-Dioxygenase and 2-Amino-3-Carboxymuconate-6-Semialdehyde Decarboxylase in the 2-Nitrobenzoate Degradation Pathway of Pseudomonas fluorescens Strain KU-7†

    OpenAIRE

    Muraki, Takamichi; Taki, Masami; Hasegawa, Yoshie; Iwaki, Hiroaki; Lau, Peter C. K.

    2003-01-01

    The 2-nitrobenzoic acid degradation pathway of Pseudomonas fluorescens strain KU-7 proceeds via a novel 3-hydroxyanthranilate intermediate. In this study, we cloned and sequenced a 19-kb DNA locus of strain KU-7 that encompasses the 3-hydroxyanthranilate meta-cleavage pathway genes. The gene cluster, designated nbaEXHJIGFCDR, is organized tightly and in the same direction. The nbaC and nbaD gene products were found to be novel homologs of the eukaryotic 3-hydroxyanthranilate 3,4-dioxygenase a...

  12. The Comparison of Canopy Height Profiles Extracted from Ku-band Profile Radar Waveforms and LiDAR Data

    Directory of Open Access Journals (Sweden)

    Hui Zhou

    2018-05-01

    Full Text Available An airborne Ku-band frequency-modulated continuous waveform (FM-CW profiling radar, Tomoradar, records the backscatter signal from the canopy surface and the underlying ground in the southern boreal forest zone of Finland. The recorded waveforms are transformed into canopy height profiles (CHP with a similar methodology utilized in large-footprint light detection and ranging (LiDAR. The point cloud data simultaneously collected by a Velodyne® VLP-16 LiDAR on-board the same platform represent the frequency of discrete returns, which are also applied to the extraction of the CHP by calculating the gap probability and incremental distribution. To thoroughly explore the relationships of the CHP derived from Tomoradar waveforms and LiDAR data we utilized the effective waveforms of one-stripe field measurements and comparison them with four indicators, including the correlation coefficient, the root-mean-square error (RMSE of the difference, and the coefficient of determination and the RMSE of residuals of linear regression. By setting the Tomoradar footprint as 20 degrees to contain over 95% of the transmitting energy of the main lobe, the results show that 88.17% of the CHPs derived from Tomoradar waveforms correlated well with those from the LiDAR data; 98% of the RMSEs of the difference ranged between 0.002 and 0.01; 79.89% of the coefficients of determination were larger than 0.5; and 98.89% of the RMSEs of the residuals ranged from 0.001 to 0.01. Based on the investigations, we discovered that the locations of the greatest CHP derived from the Tomoradar were obviously deeper than those from the LiDAR, which indicated that the Tomoradar microwave signal had a stronger penetration capability than the LiDAR signal. Meanwhile, there are smaller differences (the average RMSEs of differences is only 0.0042 when the total canopy closure is less than 0.5 and better linear regression results in an area with a relatively open canopy than with a denser

  13. Environmental radiation status in Bunkyo-ku, Tokyo, after the TEPCO Fukushima Dai-ichi Nuclear Power Plant disaster

    International Nuclear Information System (INIS)

    Ebisawa, Takao; Hirose, Seiichi; Furuta, Etsuko; Kusama, Keiji; Iimoto, Takeshi

    2013-01-01

    Bunkyo-ku is located in the eastern part of the metropolitan area of Tokyo, Japan, and is roughly 220 km south of the TEPCO Fukushima Dai-ichi Nuclear Power Plant. The population of the city was 201,079 as of August 1, 2012, and its area is 11.31 km"2. The local government has officially been surveying the environmental radiation status after the disaster in response to numerous requests from its citizens. The radiation surveillance in this area has been technically guided by radiation protection specialists. The two main targets for surveillance are (1) the ambient radiation dose (microsieverts per hour) at all the school yards, public parks, and representative measurement points selected by the local government, and (2) the specific radioactivity (becquerels per kilogram) present in school lunch. These data have been reported to the citizens through the city website as well as in a bi-monthly report in the public relations magazine of the local government. This report presents the background status and technical information of the related activities, as well as the measured environmental radiation data. The ambient radiation dose in the city has been surveyed since July 2011. In the 1st period of surveillance (from July to August, 2012), over a total of 304 measurement points, the highest recorded value of the ambient radiation dose was 0.22 μSv h"-"1 at the height of 1 m from the ground, the lowest was 0.05 μSv h"-"1, and the average was around 0.09 μSv h"-"1. These values include the natural background dose rate detected by the energy compensation type surveymeters. In the most recent surveillance records, the maximum value recorded was 0.10, the minimum was 0.05, and 0.07 μSv h"-"1 was the average value. The specific radioactivity of drinking water has been monitored at local purification plants since the accident occurred. No water sample supplied to the city has exceeded the national limits for intake dose. The specific radioactivity of school lunch was

  14. Reduction of intergranular exchange coupling and grain size for high Ku CoPt-based granular media: Metal-oxide buffer layer and multiple oxide boundary materials

    Directory of Open Access Journals (Sweden)

    Kim Kong Tham

    2018-05-01

    Full Text Available Investigation of magnetic properties and microstructure of granular media with various multiple oxides as the grain boundary material is reported. Saturation magnetization (Ms, uniaxial magnetocrystalline anisotropy (Ku, and magnetic grain diameter (GD of the granular media show linear correlation with volume weighted average for melting point (Tm of each oxides (Tmave. Ku of magnetic grains (Kugrain shows a trade-off relation with GD that it is a big challenge to satisfy both high Kugrain and small GD by only controlling Tmave. To obtain a granular medium with appropriate Kugrain, GD, and low degree of intergranular exchange coupling, the combination of Tmave control of grain boundary material by mixing oxides and employment of a buffer layer are required. Here the degree of intergranular exchange coupling is estimated from the slope of M-H loop at around coercivity (α. By applying this technique, a typical granular medium with Kugrain of 1.0×107 erg/cm3, GD of 5.1 nm, and α of 1.2 is realized.

  15. Waldenström's macroglobulinemia harbors a unique proteome where Ku70 is severely underexpressed as compared with other B-lymphoproliferative disorders

    International Nuclear Information System (INIS)

    Perrot, A; Pionneau, C; Azar, N; Baillou, C; Lemoine, F M; Leblond, V; Merle-Béral, H; Béné, M-C; Herbrecht, R; Bahram, S; Vallat, L

    2012-01-01

    Waldenström's macroglobulinemia (WM) is a clonal B-cell lymphoproliferative disorder (LPD) of post-germinal center nature. Despite the fact that the precise molecular pathway(s) leading to WM remain(s) to be elucidated, a hallmark of the disease is the absence of the immunoglobulin heavy chain class switch recombination. Using two-dimensional gel electrophoresis, we compared proteomic profiles of WM cells with that of other LPDs. We were able to demonstrate that WM constitutes a unique proteomic entity as compared with chronic lymphocytic leukemia and marginal zone lymphoma. Statistical comparisons of protein expression levels revealed that a few proteins are distinctly expressed in WM in comparison with other LPDs. In particular we observed a major downregulation of the double strand repair protein Ku70 (XRCC6); confirmed at both the protein and RNA levels in an independent cohort of patients. Hence, we define a distinctive proteomic profile for WM where the downregulation of Ku70—a component of the non homologous end-joining pathway—might be relevant in disease pathophysiology

  16. USP22 Induces Cisplatin Resistance in Lung Adenocarcinoma by Regulating γH2AX-Mediated DNA Damage Repair and Ku70/Bax-Mediated Apoptosis

    Directory of Open Access Journals (Sweden)

    Aman Wang

    2017-05-01

    Full Text Available Resistance to platinum-based chemotherapy is one of the most important reasons for treatment failure in advanced non-small cell lung cancer, but the underlying mechanism is extremely complex and unclear. The present study aimed to investigate the correlation of ubiquitin-specific peptidase 22 (USP22 with acquired resistance to cisplatin in lung adenocarcinoma. In this study, we found that overexpression of USP22 could lead to cisplatin resistance in A549 cells. USP22 and its downstream proteins γH2AX and Sirt1 levels are upregulated in the cisplatin- resistant A549/CDDP cell line. USP22 enhances DNA damage repair and induce cisplatin resistance by promoting the phosphorylation of histone H2AX via deubiquitinating histone H2A. In addition, USP22 decreases the acetylation of Ku70 by stabilizing Sirt1, thus inhibiting Bax-mediated apoptosis and inducing cisplatin resistance. The cisplatin sensitivity in cisplatin-resistant A549/CDDP cells was restored by USP22 inhibition in vivo and vitro. In summary, our findings reveal the dual mechanism of USP22 involvement in cisplatin resistance that USP22 can regulate γH2AX-mediated DNA damage repair and Ku70/Bax-mediated apoptosis. USP22 is a potential target in cisplatin-resistant lung adenocarcinoma and should be considered in future therapeutic practice.

  17. Focusing electrode and coaxial reflector used for reducing the guiding magnetic field of the Ku-band foilless transit-time oscillator

    Energy Technology Data Exchange (ETDEWEB)

    Ling, Junpu; Zhang, Jiande; He, Juntao, E-mail: hejuntao12@163.com; Wang, Lei; Deng, Bingfang [College of Optoelectronic Science and Engineering, National University of Defense Technology, Changsha 410073 (China)

    2014-08-15

    Based on the theoretical analysis of the intense relativistic electron beam propagation in the coaxial drift-tube, a focusing electrode and a coaxial reflector is proposed to lessen the demand of the coaxial Ku-band foilless transit-time oscillator (TTO) for the guiding magnetic field. Moreover, a Ku-band TTO with the focusing electrode and the coaxial reflector is designed and studied by particle in cell simulation. When the diode voltage is 390 kV, the beam current 7.8 kA, and the guiding magnetic field is only 0.3 T, the device can output 820 MW microwave pulse at 14.25 GHz by means of the simulation. However, for the device without them, the output power is only 320 MW. The primary experiments are also carried out. When the guiding magnetic field is 0.3 T, the output power of the device with the focusing electrode and the coaxial reflector is double that of the one without them. The simulation and experimental results prove that the focusing electrode and the coaxial reflector are effective on reducing the guiding magnetic field of the device.

  18. Reduction of intergranular exchange coupling and grain size for high Ku CoPt-based granular media: Metal-oxide buffer layer and multiple oxide boundary materials

    Science.gov (United States)

    Tham, Kim Kong; Kushibiki, Ryosuke; Kamada, Tomonari; Hinata, Shintaro; Saito, Shin

    2018-05-01

    Investigation of magnetic properties and microstructure of granular media with various multiple oxides as the grain boundary material is reported. Saturation magnetization (Ms), uniaxial magnetocrystalline anisotropy (Ku), and magnetic grain diameter (GD) of the granular media show linear correlation with volume weighted average for melting point (Tm) of each oxides (Tmave). Ku of magnetic grains (Kugrain) shows a trade-off relation with GD that it is a big challenge to satisfy both high Kugrain and small GD by only controlling Tmave. To obtain a granular medium with appropriate Kugrain, GD, and low degree of intergranular exchange coupling, the combination of Tmave control of grain boundary material by mixing oxides and employment of a buffer layer are required. Here the degree of intergranular exchange coupling is estimated from the slope of M-H loop at around coercivity (α). By applying this technique, a typical granular medium with Kugrain of 1.0×107 erg/cm3, GD of 5.1 nm, and α of 1.2 is realized.

  19. KU24 METAR

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — METAR is a routine scheduled observation and is the primary observation code used in the United States to satisfy requirements for reporting surface meteorological...

  20. Ku dydaktyce afirmatywnej

    Directory of Open Access Journals (Sweden)

    Monika Rogowska-Stangret

    2016-11-01

    Full Text Available "Towards affirmative didactics" The article “Towards affirmative didactics” is a description of a project reflecting on the experience of teaching and learning in a systematic and complex manner. It is also an effort to define the conditions that could encourage values such as inclusiveness, tolerance, mindfulness, joint responsibility, as well as engagement in and support for actions undertaken to strengthen the above-mentioned values. The project is a work in progress and it consists of two parts. The first one is critical and it describes the given situation by pointing the main threats involved. The second – affirmative one – was created with the effort to develop positive guidelines that would encourage transformations in the approach to didactics.

  1. Avaliação das diretrizes e ações do Plano de Mobilidade da cidade de Passo Fundo de acordo com a Lei n° 12.587/2012

    Directory of Open Access Journals (Sweden)

    Paola Pol Saraiva

    2017-12-01

    Full Text Available O agravamento dos problemas relacionados à mobilidade urbana traz à tona uma série de desafios para pensadores e corpo técnico das cidades. É de fundamental importância analisar, refletir e avaliar a consistência das políticas públicas voltadas à mobilidade, a fim de mensurar sua efetividade e aplicabilidade, bem como a coerência entre as políticas nacionais e as locais. Neste contexto, desde o ano de 2014 a cidade de Passo Fundo possui um Plano de Mobilidade, focado em ações e estratégias de curto, médio e longo prazo para melhoria da mobilidade local. Sendo assim, o presente estudo tem como objetivo principal analisar as diretrizes e ações do Plano de Mobilidade Urbana da cidade de Passo Fundo, a fim de avaliar sua compatibilidade com os princípios, diretrizes e objetivos da Lei Nacional n° 12.587/2012- Lei de Mobilidade Urbana, bem como compreender como as ações em nível local são influenciadas pelas políticas nacionais. Além disso, objetiva-se compreender como o processo de urbanização influenciou na mobilidade da cidade de Passo Fundo. A metodologia utilizada foi o levantamento documental de leis e regulamentos oficiais dedicados à mobilidade urbana das escalas nacional até a local bem como o estudo de caso da cidade analisada. Os resultados mostraram que há conformidade entre a Lei Nacional 12.587/2012 e o Plano Municipal de Mobilidade, com algumas lacunas, como a ausência de diretrizes voltadas ao uso de energias mais limpas. Nota-se, porém, que há uma grande distância entre boa parte das diretrizes locais e a aplicabilidade das mesmas na cidade, já que algumas requerem grandes investimentos.

  2. A representação da função paterna para instituições de auxílio a adolescentes em conflito com a lei

    OpenAIRE

    Silva,Ricardo Alves da; Araújo,Sandra Maria Baccara

    2013-01-01

    No presente artigo articula-se a importância da função paterna para o desenvolvimento da criança e do adolescente e como a falta dessa função faz o jovem buscar alguém que a exerça. Muitas vezes, durante essa busca, os adolescentes cometem atos infracionais que os levam a entrar em conflito com a lei e, consequentemente, entrar em contato com os atores da justiça, que podem representar os limites que esses adolescentes procuraram. A metodologia adotada é a epistemologia qualitativa, que enfoc...

  3. Repercussões da Lei Maria da Penha no enfrentamento da violência de gênero Repercussions of the Maria da Penha law in tackling gender violence

    Directory of Open Access Journals (Sweden)

    Maíra Meneghel de Quadros

    2013-03-01

    Full Text Available Este texto apresenta os discursos acerca da Lei Maria da Penha enunciados por uma amostra de mulheres vítimas e outra de operadores que atendem situações de violência de gênero na cidade de Porto Alegre. Os dados fazem parte de uma pesquisa que investigou a rota crítica percorrida pelas mulheres ao decidir denunciar a violência. Os depoimentos foram selecionados de 45 entrevistas semiestruturadas respondidas por 21 mulheres e 25 operadores do setor policial, jurídico, ação social, saúde e organizações não governamentais. Os dados foram analisados com auxílio do software NVivo e um dos temas selecionados foi a Lei Maria da Penha. A maioria dos entrevistados mencionou os aspectos positivos e inovadores da lei, embora tenham apontado também os seus limites. Os operadores percebem o dispositivo legal como recurso importante no enfrentamento às violências, alinhado às convenções internacionais, trazendo inovações e aumentando o acesso das mulheres ao judiciário. Como fragilidades, mulheres e operadores apontaram a ineficiência na aplicação das medidas protetivas, a falta de recursos materiais e de pessoas, a fragmentação da rede de atenção e o movimento de setores conservadores da sociedade para deslegitimar a Lei.This paper presents the declarations about the Maria da Penha law made by a sample of women victims and care workers who handle situations of gender violence in the city of Porto Alegre. The data are part of a study that investigated the critical path followed by women who decide to denounce violence. The statements were selected from 45 semi-structured interviews answered by 21 women and 25 professionals from the police, legal, social and health services and nongovernmental institutions. Data were analyzed using NVivo software and one of the categories selected was the Maria da Penha law. Most respondents mentioned the positive and innovatory aspects of the law, though they also pointed out its limitations

  4. Direitos humanos como limites da força aérea brasileira: a lei do abate no combate ao tráfico de drogas

    Directory of Open Access Journals (Sweden)

    Rui Carlo Dissenha

    2017-04-01

    Full Text Available Resumo: Embora bastante criticado pela doutrina nacional, o Decreto n. 5.144, de 16 de julho de 2004, permitiu o abate, pela Força Aérea, de aeronaves suspeitas de participação no tráfico de drogas em nome da defesa da soberania nacional. Neste artigo, discute-se a questão à luz da imperatividade determinada pela construção de uma importante rede normativa garantidora de direitos humanos que implica consequências ao próprio conceito de soberania. De fato, o aprofundamento político e normativo dessa soberania humanizada implica a construção de novos limites ao uso da força pelo Estado, materializados em diversos instrumentos normativos que irradiam efeitos sobre o sistema jurídico nacional. Especialmente diante das determinações do Plano Nacional de Direitos Humanos e das instruções dele decorrentes regulando o uso da força por agentes públicos federais, o Decreto n. 5.144/2004 padece de aparente inconstitucionalidade. Essa conclusão decorre da análise dos instrumentos normativos que regulam a questão e que impedem o uso de medidas militares, criadas para a proteção das fronteiras nacionais de ataques inimigos externos, contra simples acusados da prática de crimes. Ademais, a opção pelo uso do tiro de destruição como determinado no Decreto n. 5.144/2004 representa uma confusão perigosa entre as esferas da segurança pública e da segurança nacional que põe em risco o Estado Democrático de Direito e a garantia dos direitos fundamentais. Palavras-chave: Lei do Abate. Tráfico de drogas. Plano Nacional de Direitos Humanos.

  5. O impacto da lei de responsabilidade fiscal sobre a gestão financeira dos pequenos municípios: o caso do Paraná

    Directory of Open Access Journals (Sweden)

    WILLSON GERIGK

    2010-12-01

    Full Text Available Este artigo tem por objetivo mensurar e avaliar os reflexos da Lei de Responsabilidade Fiscal (LRF sobre o espaço de manobra da gestão financeira dos pequenos municípios paranaenses com população entre 10 e 20 mil habitantes, tendo como referência as peculiaridades e atribuições dos governos locais. A fundamentação teórica compreende os conceitos relacionados à organização do setor público brasileiro, LRF, administração pública gerencial, gestão municipal e, especificamente, à gestão financeira municipal. A pesquisa é caracterizada do ponto de vista metodológico como descritiva e explicativa quanto aos objetivos; bibliográfica e documental quanto aos procedimentos; e quantitativa quanto à abordagem do problema. São analisados os municípios paranaenses com população entre 10 e 20 mil habitantes que disponibilizaram informações na base de dados Finanças do Brasil, da Secretaria do Tesouro Nacional (Finbra. A técnica estatística empregada é a regressão linear múltipla. Nas análises de regressão, foram incluídas 22 variáveis explicativas, envolvendo aspectos financeiros e de gestão dos municípios. Conclui-se que o espaço de manobra dos pequenos municípios paranaenses não foi reduzido pela LRF como era esperado e, sim, aumentado tanto em termos absolutos como em termos relativos, o que evidência significativa melhoria da gestão financeira. Além disso, as análises de regressão e as análises complementares envolvendo o coeficiente de espaço de manobra sobre as despesas correntes mostram significativa mudança estrutural como decorrência da LRF.

  6. Sunspots and the Newcomb-Benford Law. (Spanish Title: Manchas Solares y la Ley de Newcomb-Benford.) Manchas Solares e a Lei de Newcomb-Benford

    Science.gov (United States)

    Alves, Mauro A.; Lyra, Cássia S.

    2008-12-01

    The Newcomb-Benford's Law (LNB) of first digits is introduced to high school students in an extracurricular activity through the study of sunspots. The LNB establishes that the first digits of various sets of data describing natural occurrences are not distributed uniformly, but according to a logarithmic distribution of probability. The LNB is counter-intuitive and is a good example of how mathematics applied to the study of natural phenomena can provide surprising and unexpected results serving also as a motivating agent in the study of physical sciences. En este trabajo se describe una actividad extracurricular donde se presenta a los estudiantes la ley de los primeros dígitos de Newcomb-Benford (LNB) con el estudio de manchas solares. La LNB establece que los primeros dígitos de algunos tipos de dados de ocurrencia natural no están distribuidos en manera uniforme, pero sí de acuerdo con una distribución logarítmica de probabilidad. La LNB es contra-intuitiva y es un excelente ejemplo de como las matemáticas aplicadas al estudio de fenómenos naturales pueden sorprender al estudiante, sirviendo también como elemento motivador en la educación de ciencias y de matemáticas. Este trabalho descreve uma atividade extracurricular na qual a lei dos primeiros dígitos de Newcomb-Benford (LNB) é introduzida a estudantes através do estudo de manchas solares. A LNB estabelece que os primeiros dígitos de vários tipos de conjunto de dados de ocorrência natural não são distribuídos de maneira uniforme, mas sim de acordo com uma distribuição logarítmica de probabilidade. A LNB é contra-intuitiva e é um ótimo exemplo de como a matemática aplicada ao estudo de fenômenos naturais pode fornecer resultados surpreendentes e inesperados, servindo também como um agente motivador no ensino de ciências e matemática.

  7. Volcanology of Tuzo pipe (Gahcho Kué cluster) — Root-diatreme processes re-interpreted

    Science.gov (United States)

    Seghedi, I.; Maicher, D.; Kurszlaukis, S.

    2009-11-01

    The Middle Cambrian (~ 540 Ma) Gahcho Kué Kimberlite Field is situated about 275 km ENE of Yellowknife, NWT, Canada. The kimberlites were emplaced into 2.6 Ga Archean granitic rocks of the Yellowknife Supergroup. Four larger kimberlite bodies (5034, Tesla, Tuzo, and Hearne) as well as a number of smaller pipes and associated sheets occur in the field. In plan view, the Tuzo pipe has a circular outline at the surface, and it widens towards deeper levels. The pipe infill consists of several types of coherent and fragmental kimberlite facies. Coherent or apparent coherent (possibly welded) kimberlite facies dominate at depth, but also occur at shallow levels, as dikes intruded late in the eruptive sequence or individual coherent kimberlite clasts. The central and shallower portions of the pipe consist of several fragmental kimberlite varieties that are texturally classified as Tuffisitic Kimberlites. The definition, geometry and extent of the geological units are complex and zones controlled by vertical elements are most significant. The fluidal outlines of some of the coherent kimberlite clasts suggest that at least some are the product of disruption of magma that was in a semi-plastic state or even of welded material. Ragged clasts at low levels are inferred to form part of a complex peperite-like system that intrudes the base of the root zone. A variable, often high abundance of local wall-rock xenoliths between and within the kimberlite phases is observed, varying in size from sub-millimeter to several tens of meters. Wall-rock fragments are common at all locations within the pipe but are especially frequent in a domain with a belt-like geometry between 120 and 200 m depth in the pipe. Steeply outward-dipping bedded deposits made up of wall-rock fragments occur in deep levels of the pipe and are especially common under the downward-widening roof segments. The gradational contact relationships of these deposits with the surrounding kimberlite-bearing rocks as well

  8. Generation, Transformation and Place in Inga Iwasiów’s Novels Bambino (2008 and Ku słońcu (2010

    Directory of Open Access Journals (Sweden)

    Ursula PHILLIPS

    2012-06-01

    Full Text Available This chapter will discuss two novels by contemporary writer Inga Iwasiów (b. 1963, Bambino (2008 and Ku słońcu [Towards the Sun] (2010, in the context of geopolitical, ideological, social and psycho-cultural transformations as they specifically affect different generations of inhabitants of the Polish city of Szczecin (pre-1945 German Stettin from 1945 until the first decade of the 21st century. Bambino covers the years 1945–1981, but also contains flashbacksto pre-war memory of Stettin and to the suppressed experiences of the new post-war inhabitants, as well as ‘flash-forwards’ to post-1989, post-communist reality; Ku słońcu covers 1981 to the first decade of 2000s. It will show how the novels portray these transformations through the experience primarily of women (but not only — in Bambino, through the main protagonists: Ula (formerly Ulrike, Anna and Marysia, and through that of the hidden narrator Magda (Marysia’s daughter born in the same year as the author, Iwasiów, 1963; and in Ku słońcu, primarily through the experience of Magda herself, as well as through that of two generations of ‘feminist’ academics: Małgorzata and Sylwia (in which it is hard not to perceive the personal experience of the author, though she is at pains to emphasize elsewhere that her work is a collective biography of the city, not so much of herself. The analysis follows Katarzyna Chmielewska’s supposition that contemporary Polish fiction dealing with the past ‘constantly oscillates between memory and genealogy’, and that it raises raw issues not yet addressed by historians; it also derives inspiration from the new ‘postdependency’ studiesproposed by Hanna Gosk and Ryszard Nycz. It also attempts to capture the specific nature of Iwasiów’s use of language, her style of feminism, her method of portraying place, and the connections in her prose between place and memory.

  9. Acordo Coletivo com propósito específico e o projeto de lei 4193/2012: as convergências em torno de uma pretensa desregulamentação trabalhista via negociação coletiva.

    OpenAIRE

    Ana Flavia Dantas Figueirêdo Silva

    2014-01-01

    A dissertação tem por objetivo analisar o anteprojeto de lei denominado Acordo Coletivo com propósito específico/ Acordo Coletivo Especial-ACE, criado pelo Sindicato dos Metalúrgicos do ABC e entregue no início de 2011 ao Poder Executivo Federal e o projeto de lei 4193 de 2012 de autoria do deputado Irajá Abreu. O anteprojeto propõe alteração legislativa com fim à concretização dos comitês sindicais de empresa, buscando uma suposta democratização nas relações de trabalho com a possibilidad...

  10. Violência conjugal: desafios e propostas para a aplicação da Lei Maria da Penha = Marital violence: challenges and proposals for the application of “Maria da Penha” Law

    Directory of Open Access Journals (Sweden)

    Cortez, Mirian Beccheri

    2013-01-01

    Full Text Available Analisamos o discurso de um casal de classe média, divorciado devido a ameaças de morte do marido à esposa, visando investigar sua dinâmica afetiva e familiar, suas vivências de violência conjugal (motivações de conflitos e desdobramentos da denúncia em uma Delegacia da Mulher, suas concepções de gênero, violência e relacionamento. A partir do caso, abordamos questões que consideramos relevantes para a aplicabilidade da Lei Maria da Penha. Os dados foram obtidos através de entrevistas individuais semiestruturadas e submetidos a uma análise fenomenológica. Os resultados indicam fatores facilitadores de ocorrência de conflitos entre o casal (licença trabalhista da esposa, consumo excessivo de bebida alcoólica pelo marido e morte de seu pai, assim como apontam desafios existentes para aumentar a efetividade da Lei Maria da Penha e a importância da gestão democrática na construção de políticas públicas de enfrentamento à violência de gênero

  11. A lei n. 5.692/71 e a obrigatoriedade da educação artística nas escolas: passados quarenta anos, prestando contas ao presente

    Directory of Open Access Journals (Sweden)

    Maria José Dozza Subtil

    2013-02-01

    Full Text Available Analisa-se a lei n. 5.692/71 na instituição da obrigatoriedadeda educação artística, explicitando seus fundamentos teóricometodológicose problematizando-a por meio de pesquisa emdocumentos legais, artigos, livros didáticos e projetos de trabalho.Fundamentos do materialismo histórico e dialético subsidiam aanálise histórica no contexto externo e interno à escola, com suportedas categorias totalidade e contradição, além do recurso à históriadas disciplinas. Afirma-se que os encaminhamentos metodológicospropunham a adequação da escola, dos professores e da disciplinaa um projeto tecnicista de desenvolvimento econômico e controleda realidade social. Autores são chamados para refletir sobre osfundamentos da lei e sua permanência ainda hoje na realidadeescolar.

  12. En australsk øjenåbner

    DEFF Research Database (Denmark)

    Ingemann, Jan Holm

    2008-01-01

    I Europæisk sammenhæng er vi vant til at tænke, at økologisk jordbrug er certificeret. Det skyldes, at certificering er forudsætning for merpris og for særlige subsidier. I Australien er subsidier stort set fraværende, og en lang række producenter anvender følgelig økologiske metoder uden at være...

  13. Farmand i trøjen

    DEFF Research Database (Denmark)

    Schubart, Rikke

    2008-01-01

    Artikel om den amerikanske soldat som far-heltefigur (Daddy Soldier) i den amerikanske krigsfilm fra 1991-2008 Udgivelsesdato: summer......Artikel om den amerikanske soldat som far-heltefigur (Daddy Soldier) i den amerikanske krigsfilm fra 1991-2008 Udgivelsesdato: summer...

  14. Støjen bliver synlig

    DEFF Research Database (Denmark)

    Rindel, Jens Holger

    1997-01-01

    A draft standard INSTA 122:1997 on sound classification of dwellings is for voting as a common national standard in the Nordic countries (Denmark, Norway, Sweden, Finland, Iceland) and in Estonia. The draft standard specifies a sound classification system with four classes A, B, C and D, where cl...... class C is proposed as the future minimum requirements for new dwellings. The classification system is based on limit values for airborne sound insulation, impact sound pressure level, reverberation time and indoor and outdoor noise levels.......A draft standard INSTA 122:1997 on sound classification of dwellings is for voting as a common national standard in the Nordic countries (Denmark, Norway, Sweden, Finland, Iceland) and in Estonia. The draft standard specifies a sound classification system with four classes A, B, C and D, where...

  15. Projekt "Challenger" / Jens Schröder

    Index Scriptorium Estoniae

    Schröder, Jens, 1961-

    2010-01-01

    See oli okeanoloogia ajaloo esimene mastaapne teadusprojekt. 1872. aastal asus Briti korvett "HMS Challenger" teele kolme ja poole aastasele ekspeditsioonile ümber maakera. Teadlased uurisid võõraid rahvaid ja ookeanimaailma

  16. Obhájené dizertace 2016

    Czech Academy of Sciences Publication Activity Database

    Jáchimová, Veronika

    2017-01-01

    Roč. 65, č. 1 (2017), s. 163-165 ISSN 0009-0468 R&D Projects: GA MŠk(CZ) LM2015059 Institutional support: RVO:68378068 Keywords : Czech literature * dissertation Subject RIV: AJ - Letters, Mass-media, Audiovision OBOR OECD: Specific literatures

  17. Skolko pogibshihh v Tshetshenskoi voine? / Jens Hartmann

    Index Scriptorium Estoniae

    Hartmann, Jens

    2005-01-01

    Tšetšeenia Riiginõukogu esimehe Tauss Dzhabrailovi sõnul on kahe Tšetšeenia sõja vältel hukkunud 160 000 inimest. Inimõigusorganisatsiooni Memorial andmetel aga tapeti kahe sõja vältel 75 000 tsiviilisikut ja 14 000 sõjaväelast

  18. Vecāku audzināšanas stila saistība ar pusaudžu vientulības izjūtu

    OpenAIRE

    Vlasova, Iveta

    2013-01-01

    Pētījuma jautājums: Vai starp mātes audzināšanas stilu un vientulības līmeni pusaudžiem pastāv saistība? Pētījuma dalībnieki. Viena izlase, pēc pieejamības principa. Dalībnieku vecums: 12-16 gadi, 31 meitene, 23 zēni. Dzīvojoši pilnās ģimenēs. Pētījuma metode. 1.Lieto, lai noteiktu kopējo vientulības izjūtas līmeni, tika izmantota Vientulības skala (UCLA Loneliness Scale/UCLA LS/, VERSION 3; Russel, D.W. 1996).– visu jautājumu summa. 2.Vecāku audzināšanas stila aptauja (Parental...

  19. Vecāku audzināšanas stilu saistība ar pašcieņu pusaudžu vecumā

    OpenAIRE

    Miķelsone-Ježaka, Dace

    2008-01-01

    Darba mērķis ir izpētīt pašcieņas saistību ar mātes un tēvu audzināšanas stilu bērnībā. Pētījumā piedalījās 105 pusaudži no dažādām skolām vecumā no 16 līdz 18 gadiem, kas dzīvo pilnās ģimenēs. Tika izmantotas 2 aptaujas: 1. Vecāku autoritātes novērtējuma aptauja (The Parental Authority Questionnaire, Buri, 1991; Griškina, 2002). 2. Rozenberga pašcieņas aptauja (The Rosenberg Self – esteem Scale, Rosenberg, 1965).

  20. Motorické projevy laterality u osob středního věku a starších

    OpenAIRE

    Habartová, Lucie

    2008-01-01

    Název dielomové eráce: Motorické projevy laterality u osob středního věku a starších. Název v gnglickém jazyce: The Manifestations of Motoric Laterality of Middle-aged People and Elderly. Cíle eráce: Definovat, popsat lateralitu, zjistit stupeň laterality horní končetiny, dolní končetiny a oka. Zjistit vztah laterality horních končetin a očí, horních končetin a dolních končetin. Metoda: Lateralitu budeme zjišťovat na základě dotazníků a motorických testů. Testovaný soubor čítá 50 probandů ve ...

  1. Wpływ wysiłku fizycznego na funkcję układu oddechowego w twardzinie układowej

    OpenAIRE

    Stanisław Sierakowski; Ewa Gińdzieńska-Sieśkiewicz; Maciej Kaczmarski; Zenon Siergiejko; Grzegorz Siergiejko; Piotr Siergiejko; Justyna Fryc

    2010-01-01

    Cel: Powikłania ze strony układu oddechowego stanowią główną przyczynę zgonów pacjentów z twardziną układową (TU). Tętniczenadciśnienie płucne i śródmiąższowa choroba płuc stanowią najistotniejszez nich. Pacjenci są jednak często zdiagnozowani dopierow późnym okresie choroby, dlatego też istotne jest opracowaniemetody diagnostycznej do wczesnego wykrywania tych powikłań.Celem pracy była ocena wpływu wysiłku fizycznego na zmiany parametrówoddechowych. Materiały i metody: Badania przeprowadzono...

  2. A Novel Ku-Band/Ka-Band and Ka-Band/E-Band Multimode Waveguide Couplers for Power Measurement of Traveling-Wave Tube Amplifier Harmonic Frequencies

    Science.gov (United States)

    Wintucky, Edwin G.; Simons, Rainee N.

    2015-01-01

    This paper presents the design, fabrication and test results for a novel waveguide multimode directional coupler (MDC). The coupler, fabricated from two dissimilar frequency band waveguides, is capable of isolating power at the second harmonic frequency from the fundamental power at the output port of a traveling-wave tube (TWT) amplifier. Test results from proof-of-concept demonstrations are presented for a Ku-band/Ka-band MDC and a Ka-band/E-band MDC. In addition to power measurements at harmonic frequencies, a potential application of the MDC is in the design of a satellite borne beacon source for atmospheric propagation studies at millimeter-wave (mm-wave) frequencies (Ka-band and E-band).

  3. Y Kuşağının Mobil Öğrenme Uygulama Tercihini Etkileyen Faktörlerin İncelenmesi

    OpenAIRE

    ALTUNTAŞ, Başar

    2017-01-01

    Mobilteknolojilerin öğrenme ortamlarına dâhil edilmesiyle birlikte öğrenme faaliyetifiziksel sınırların dışına çıkmış ve farklı bir boyuta evrilmiştir. Tasarlanan öğrenmeuygulamaları kullanıcılarına zamandan ve mekândan bağımsız öğrenme fırsatısunarken, yeni ve farklı deneyimleri de beraberinde getirmiştir. Bu çalışmada,Y kuşağının mobil öğrenme uygulamalarını tercih etmesini ve kullanmasınıetkileyen faktörler incelenmiştir. Teknoloji kabul modeli ile beklenti-kabul modelitemelinde tasarlanan...

  4. From Resident to President: The Sinuous Participation of Paraguayan Women in Politics and the Emergence of the Feminist Political Movement Kuña Pyrenda

    Directory of Open Access Journals (Sweden)

    Sarah Cerna Villarga

    2015-07-01

    Full Text Available Paraguayan women have transcended history as the mothers of the “Guarani breed”, as The Resident Woman Residentas, the social role of these has been undeniable, but in other scopes, such as the political area, its social and historical role is still invisible, because the policy has historically been considered a male activity. However, many women have contributed to the construction of the history of this nation, and although the asymmetries in the real access to power between men and women are notorious today, Paraguayan want power and will seek, as it was found in the last two presidential elections of 2008 and 2013. On this basis, this paper aims to describe what has been the impact of feminism in Paraguayan politics and, in turn, explain the factors that have influenced raid Kuña Pyrenda feminist movement in the elections of 2013.

  5. Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017; Venice (Italy; October 31-November 4, 2017; Session "Neonatal Pulmonology, Neonatal Respiratory Support, Resuscitation"

    Directory of Open Access Journals (Sweden)

    --- Various Authors

    2017-10-01

    Full Text Available Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017; Venice (Italy; October 31-November 4, 201758th ESPR Annual Meeting, 7th International Congress of UENPS, 3rd International Congress of EFCNIORGANIZING INSTITUTIONSEuropean Society for Paediatric Research (ESPR, European Society for Neonatology (ESN, Union of European Neonatal & Perinatal Societies (UENPS, European Foundation for the Care of Newborn Infants (EFCNIORGANIZING COMMITTEELuc Zimmermann (President of ESPR, Morten Breindahl (President of ESN, Manuel Sánchez Luna (President of UENPS, Silke Mader (Chairwoman of the Executive Board and Co-Founder of EFCNISCIENTIFIC COMMITTEEVirgilio P. Carnielli (Congress President Chair, Pierre Gressens (Past Scientific President, Umberto Simeoni, Manon Benders, Neil Marlow, Ola D. Saugstad, Petra Hüppi, Agnes van den HoogenSession "Neonatal Pulmonology, Neonatal Respiratory Support, Resuscitation"ABS 1. HOW SAFE IS NASAL CANNULAE OXYGEN THERAPY DURING NEONATAL TRANSPORT? • A. Brunton, J. O’Shea, A. JacksonABS 2. WEANING PREMATURE INFANTS FROM NASAL CONTINUOUS POSITIVE AIRWAY PRESSURE – CURRENT PRACTICE IN GERMANY • A. Kidszun, C. Arnold, J. Winter, C. Whybra-Trümpler, E. MildenbergerABS 3. TIMING OF KEY EVENTS IN NEONATAL RE­SUSCITATION • A. Heathcote, J. Jones, P. ClarkeABS 4. COMPARING NON-INVASIVE VENTILATION METHODS IN RESPIRATORY SUPPORT OF PRETERM NEONATES WITH RESPIRATORY DISEASES • A.S. Farhat, A. Mohammadzadeh, G.A. Mamuri, R. Saeidi, S. NoorizadehABS 5. PREDICTORS AND OUTCOMES OF CONTINU­OUS POSITIVE AIRWAY PRESSURE AND NA­SAL HIGH-FLOW TREATMENT FAILURE IN PRE­TERM INFANTS: A SECONDARY ANALYSIS OF A RANDOMIZED TRIAL • B. Manley, C. Roberts, D. Frøisland, L. Doyle, P. Davis, L. OwenABS 6. NEONATAL NON-INVASIVE RESPIRATORY SUPPORT APPROACH: A TWO COUNTRIES COMPARISON • I. Bresesti, S. Zivanovic, G. Lista, C. RoehrABS 7. PREDICTORS OF EARLY CPAP FAILURE IN VERY LOW BIRTH WEIGHT PRETERM

  6. Kinetics of destruction of KU-2 x 8 and AV-17 x 8 ion-exchange resins by the joint action of heating and irradiation

    International Nuclear Information System (INIS)

    Tulupov, P.E.; Butenko, T.Yu.

    1982-01-01

    Experimental data indicates a decrease of the exchange capacity of AV-17 x 8 (OH) resin in ion-exchange beds at various temperatures. Losses of exchange of the resin in hydroxyl form after 10,000h of continuous heating at 60, 70, and 80 0 C are 24, 44, and 78% respectively. Partial replacement of the hydroxyl by the salt form is accomplished by appreciable lowering of capacity losses. The trimethlyamine evolved during deamination of AV-17 x 8 anion exchange resin, and only methanol, enters the coolant. Under the influence of ionizing radiation in the active zone the methanol will be converted successively into formaldehyde, formic acid and CO 2 . Thus the maximum temperature of use of the hydroxyl form of te anion-exchange resin AV-17 x 8 (OH) in nuclear power plants can be raised to 70-75 0 C. Brief changes of temperature at 100 0 C do not cause any appreciable losses of exchange capacity either. Physicochemical properties of ion-exchange resins after use in nuclear power plants leads to excessive and unjustified restriction of their service life in the course of a single cycle. Joint action of heating and irradiation on AV-17 anion-exchange resin was studied. It was found that rate constants of the processes of thermal radiation decreases the exchange capacities of the resins in the temperature ranges of interest with relation to nuclear power plants. Calculation of the stability of KU-2 x 8 cation-exchange resin shows that even after a year of use at 100 0 C the loss of its exchange capacity is less than 0.1%. Therefore, under the conditions of use in a nuclear power plant KU-2 x 8 resin can be regarded as absolutely stable. The loss of exchange capacity of AV-17 x 8 resin in C1 form at 100 0 C is of similar magnitude

  7. The law of biosecurity under the boarding of the discourse ethics A lei de biossegurança sob a abordagem da ética discursiva

    Directory of Open Access Journals (Sweden)

    Simone Vinhas de Oliveira

    2007-12-01

    temeridades. Nesse sentido, a ética discursiva representa uma peça chave de um projeto de radicalização democrática pelo qual são válidas e aceitas normas que exprimem uma vontade universal no desenvolvimento biotecnológico - Princípio Universal. E essa vontade, como uma vontade racional definida pela intersubjetividade da racionalidade comunicativa, só seguirá uma norma se ela for universal na medida em que todos os setores interessados no desenvolvimento biotecnológico participarem dos discursos – Princípio do Discurso. Para Habermas, as normas fundamentadas discursivamente fazem valer ao mesmo tempo duas coisas: o conhecimento daquilo que a cada momento reside no interesse de todos, bem como uma vontade geral que apreendeu em si mesma, sem repreensão, a vontade de todos. Diante desses fundamentos, tecem-se reflexões sobre um dos efeitos da Lei de Biossegurança - a criação de um poder discricionário da CTNBio e a ausência de regulamentação do CNBS. Tais fatos são assimétricos para o atual modelo democrático, bem como impossibilita um processo de radicalização democrática.

  8. OFICINA DE FILMES E RELAÇÕES RACIAIS: MATERIAIS PARA APLICAÇÃO DA LEI FEDERAL Nº 10.639/03 NO ENSINO BÁSICO

    Directory of Open Access Journals (Sweden)

    Gabriel Romagnose Fortunato de Freitas Monteiro

    2011-07-01

    Full Text Available Pretendemos expor neste artigo algumas informações coletadas a partir da realização de uma oficina de filmes tendo como objetivo a aplicação da Lei Federal nº 10.639/03 no ensino básico, mostrando como esta atividade pode contribuir para a revisão das práticas dos professores no que diz respeito a temática racial. O público foi composto por docentes do segundo segmento do ensino fundamental de uma escola da rede municipal de Niterói no estado do Rio de Janeiro. Apresentaremos a estrutura da oficina, assim como as suas estratégias de abordagem para a discussão das relações raciais no cotidiano escolar. Ademais, teceremos algumas discussões a partir do documentário “Vista Minha Pele” (2003 e dos relatos dos professores sobre a atividade. 1024x768 Normal 0 21 false false false PT-BR X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Tabela normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} Abstract: We want to expose in this article some information collected from the holding of a workshop of films having as goal the implementation of Federal Law No. 10,639/03 in primary education, showing how this activity can contribute to the review of the practices of teachers regarding racial thematic. The audience was composed of teachers of the second segment of the elementary school of the municipal network of Niterói, Rio de Janeiro State. We will present the

  9. Morbidade psiquiátrica entre adolescentes em conflito com a lei Psychiatric morbidity among adolescents in conflict with the law

    Directory of Open Access Journals (Sweden)

    Solange Rubim de Pinho

    2006-01-01

    Full Text Available OBJETIVO: Descrever o perfil psiquiátrico, destacando os transtornos em co-morbidade entre os adolescentes em conflito com a lei da Casa de Acolhimento ao Menor (CAM, Salvador-BA, em 2003. MÉTODOS: Estudo de corte transversal, de caráter censitário, em população de 290 jovens cumprindo medidas de privação de liberdade. Utilizaram-se questionário para identificar dados demográficos, sinais e sintomas psicopatológicos e entrevista semi-estruturada para o exame dos adolescentes. RESULTADOS: Perfil sociodemográfico: 89,3% sexo masculino; 63,9% entre 15 e 18 anos incompletos; 95,1% com ensino fundamental incompleto ou analfabeto; 67,6% com renda familiar menor que um salário mínimo e 54% naturais da capital do estado da Bahia. Dos 290 indivíduos, 24,8% não apresentaram transtornos mentais e 75,2% preencheram critérios para um ou mais transtornos psiquiátricos de acordo com a décima revisão da Classificação Internacional de Doenças (CID-10. Entre os 218 jovens portadores de patologia, 47,7% apresentaram transtornos em co-morbidade.Aassociação de patologia mais prevalente foi entre transtornos de conduta e transtornos por uso nocivo de substância psicoativa (13,4%. Transtornos hipercinéticos só foram freqüentes quando associados a outras condições (10,7%. O uso nocivo de substância psicoativa foi identificado em combinação com os diversos quadros psiquiátricos. CONCLUSÃO: Observou-se alta taxa de co-morbidade psiquiátrica, sugerindo a necessidade de estratégias terapêuticas específicas entre jovens portadores de transtornos mentais envolvidos com a justiça.OBJECTIVE: To describe the psychiatric profile, with emphasis on psychiatric comorbidities, of adolescents in conflict with the law interned on Casa de Acolhimento ao Menor (CAM, Salvador, Bahia, 2003. METHODS: This is a cross-sectional census study that enrolled a population of 290 adolescents kept on a deprivation of liberty regimen. Aquestionnaire was used

  10. A teoria kantiana do respeito pela lei moral e da determinação da vontade Kant's theory of respect for the moral law of the determination of the will

    Directory of Open Access Journals (Sweden)

    Julio Esteves

    2009-01-01

    Full Text Available Este artigo tem por objetivo examinar uma tensão existente no interior da teoria kantiana do respeito pela lei moral. Originalmente, na Fundamentação, o respeito é concebido por Kant como um mero efeito ou subproduto da imediata determinação da vontade pela lei moral. Na segunda Crítica, contudo, Kant parece conceder um papel mais positivo ao respeito, dando a ele a tarefa de enfraquecer a influência exercida pelas inclinações, o que contaria como uma promoção da influência da lei moral sobre a vontade. Buscaremos mostrar que essa alteração na teoria kantiana do respeito é inteiramente devida a uma concessão a um difundido modelo de determinação da vontade que é de inspiração humiana. Além disso, buscaremos mostrar que esse modelo humiano tem de ser completamente abandonado, porque ele se choca tanto com a concepção refletida de Kant sobre motivação moral quanto com sua concepção refletida sobre a determinação da vontade pelas inclinações.This paper intends to examine a tension within Kant's theory of respect for the moral law. Originally, in the Groundwork, respect is conceived by Kant as a mere effect or by-product of the immediate determination of the will by the moral law. However, in the Second Critique, Kant seems to confer to respect a more positive role by assigning to it the task to weaken the influence exercised by the inclinations, thereby promoting the influence of the moral law on the will. We show that this shift in Kant's theory of respect is entirely due to a concession to a widespread model of determination of the will by inclinations, which is of Humean inspiration. Besides, we show that that Humean model must be completely abandoned because it is at odds both with Kant's considered view of moral motivation and of the determination of the will by inclinations.

  11. BIOTECNOLOGIA, DESENVOLVIMENTO E INOVAÇÃO: REFLEXÕES ACERCA DA PROPRIEDADE INTELECTUAL, LEI DE CULTIVARES E DA LICENÇA COMPULSÓRIA NO ÂMBITO DA BIOTECNOLOGIA

    Directory of Open Access Journals (Sweden)

    Fabiane Oliveira

    2014-12-01

    Full Text Available Considera-se o contexto dos processos de inovação e desenvolvimento no mundo moderno, a preocupação socioambiental e a tecnologia desenvolvida em função da agroindústria. Destaca-se a crescente importância conferida à biotecnologia na sociedade contemporânea. Reflete-se criticamente o estudo da propriedade intelectual no âmbito da biotecnologia em face do Estado e da inovação e do desenvolvimento. Busca-se, primeiramente, apresentar definição, origem e aspecto relevante da biotecnologia, a fim de tornar a sapiência desta ciência mais pragmática. Posto isso, elucida-se sobre a área de abrangência da proteção da propriedade intelectual nesse ramo da ciência. Nesse viés, ocupa-se também de demonstrar a Lei de Propriedade Intelectual mediante a problemática das patentes no setor biotecnológico. Observa-se, a seguir, o estudo da Lei de Cultivares em função da utilização do mecanismo de prospecção de patentes. Demonstra-se os aspectos importantes e o impacto da Lei de Cultivares no âmbito da propriedade intelectual. Exemplifica-se as cultivares protegidas. Apresenta-se a problemática da licença compulsória no âmbito da propriedade intelectual no ramo da biotecnologia. Objetiva-se demonstrar a situação desse ramo da ciência sob o prisma da propriedade intelectual, do fortalecimento e da padronização desses direitos. Expõe-se, por último, a importância da proteção dessa ciência para o desenvolvimento e para a inovação no país. Para isso, recorta-se a analise atual da Biotecnologia e da Propriedade Intelectual no Brasil sob o enfoque da legislação especifica e da hipótese da licença compulsória. Utiliza-se de pesquisa bibliográfica na área de biotecnologia, economia e direito, sob o enfoque da propriedade intelectual, inovação e do desenvolvimento.

  12. O dogma da formalidade visível e inoperante ante a constatação necessária de medidas reais ao combate da violência contra a mulher: Lei Maria da Penha (da igualdade formal à igualdade real-material

    Directory of Open Access Journals (Sweden)

    Denigelson da Rosa Ismael

    2010-12-01

    Full Text Available A violência contra a mulher no Brasil é um mal que atravessa os séculos. Está enraizada em uma retrógrada imagem em que a mulher era fantoche do homem, e, mesmo com a Declaração dos Direitos Humanos, o advento da Constituição Federal de 1988 e com tantos Tratados e Convenções Internacionais ratificados pelo Brasil, o quadro continua inerte. No intuito de inibir a violência afetiva, familiar e doméstica contra a mulher, foi promulgada, em 2006, a Lei Maria da Penha, caracterizada, principalmente, pela sua dúplice função proteção/coibição. Todavia, como se trata de uma lei amparada em uma ação afirmativa que impõe medidas de diferenciação, muito se tem discutido a respeito de sua constitucionalidade. Portanto, o presente estudo propõe-se a construir uma reflexão, analisando os mecanismos de proteção à mulher inseridos no corpo da Lei Maria da Penha, como institutos reais de combate ao dogma da igualdade formal visível (existente e inoperante, possibilitando alcançar à mulher um esboço da igualdade real-material. Palavras-chave: Violência contra mulher. Lei Maria da Penha. Igualdade formal. Igualdade real-material. Constitucionalidade.

  13. Computação algébrica no cálculo das variações: determinação de simetrias e leis de conservação

    OpenAIRE

    Gouveia, Paulo D.F.; Torres, Delfim F.M.

    2005-01-01

    Os problemas de optimização dinâmica (em espaços de funções) tratados pelo calculo das variações, são normalmente resolvidos por recurso às condições necessárias de Euler-Lagrange, que são equações diferenciais de segunda ordem (ou de ordem superior, quando os problemas variacionais envolvem derivadas de ordem superior a um). Estas equações são, em geral, não lineares e de difícil resolução. Uma forma de as simplificar consiste em obter leis de conservação: primeiros integrais ...

  14. A Lei 14.023/07 e os Investimentos em EducaÃÃo Fundamental e SaÃde nos MunicÃpios Cearenses: Uma AnÃlise no perÃodo 2006-2010

    OpenAIRE

    Felipe Gomes Garcia

    2012-01-01

    O estudo investiga o efeito da mudanÃa nas regras do cÃlculo da cota parte do ICMS sobre os investimentos das prefeituras cearenses, nas Ãreas de ensino fundamental e saÃde. Um painel com 171 municÃpios cearenses com dados anuais entre 2006 e 2010 deu suporte à estimaÃÃo de modelos economÃtricos que permitiram constatar um impacto positivo e crescente sobre a evoluÃÃo dos repasses de recursos Ãs Ãreas supracitadas a partir a data de promulgaÃÃo da Lei 14.023/07. Controlando pelo ICMS transfer...

  15. A ordem errática e a instituição do modelo de gestão previsto no decreto-lei 115-A/98 : narrativas de uma vivência

    OpenAIRE

    Castro, Zélia Maria de Oliveira Pereira

    2014-01-01

    Este trabalho desenvolve-se em torno da análise sociopolítica e teórico-conceptual da realidade educativa e escolar, aquando da aplicação do decreto-lei n.º 115-A/98 que aparece nas estruturas do Ministério da Educação, como o normativo que vem regulamentar os órgãos de direção e gestão e, consequentemente, aprofundar a autonomia das escolas. Procura abordar, fundamentalmente, as interconexões entre as duas dimensões organizadas, estudadas no âmbito da teoria das organizações: a dimensão raci...

  16. O MODELO CURRICULAR DA LEI 5.692/1971 DURANTE A DITADURA MILITAR PARA O CURSO DE MAGISTÉRIO E SUAS IMPLICAÇÕES NA FORMAÇÃO DOCENTE NO BRASIL E EM SANTA CATARINA

    Directory of Open Access Journals (Sweden)

    Jéferson Silveira Dantas

    2015-10-01

    Full Text Available Este artigo procura discutir as implicações pedagógicas trazidas pela implementação da Lei 5.692/1971 no contexto da Ditadura Militar (1964-1985 e os seus efeitos na formação docen-te no Brasil e em Santa Catarina, sobretudo, nas séries iniciais do Ensino Fundamental, ante-riormente denominado de ensino primário. Além disso, tal estudo procura empreender uma análise da reorganização curricular no ensino de 1º e 2º graus em conformidade com a reestru-turação produtiva do capital, contando para isso com o apoio de determinados intelectuais orgânicos que apoiavam o regime militar.

  17. EDUCAÇÃO NÃO ESCOLAR NO DESENVOLVIMENTO DE MEDIDAS SOCIOEDUCATIVAS EM INSTITUIÇÕES DE INTERNAÇÃO PARA JOVENS EM CONFLITO COM A LEI

    Directory of Open Access Journals (Sweden)

    Julio Cesar Francisco

    2017-08-01

    Full Text Available Este artigo aborda a educação não escolar como campo de ações socioeducativas. A problemática investigada é a dos jovens em conflito com a lei e institucionalizados e a reorientação das práticas socioeducativas para uma formação humanizadora. O objetivo reside em apresentar e refletir sobre alguns desafios e conflitos internos do sistema socioeducativo de privação da liberdade, apontando possibilidades educativas para o campo da educação não escolar. Metodologicamente, o artigo vale-se de uma pesquisa bibliográfica e de campo. Considera, na conclusão, a necessidade da participação do jovem em processos educativos em liberdade, na comunidade, em vista de uma cultura da paz.

  18. Menores em conflito com a lei em Moçambique: reflexões sobre medidas socioeducativas e limites para sua aplicação prática

    Directory of Open Access Journals (Sweden)

    Tomás Xavier Francisco

    2014-06-01

    Full Text Available Este artigo tem por fim analisar, por um lado, a problemática dos adolescentes em conflito com a lei em Moçambique, e por outro lado, fazer reflexões sobre as medidas socioeducativas e limites para a sua aplicação prática. O trabalho contempla uma introdução, desenvolvimento onde arrola-se considerações sobre o histórico da legislação sobre adolescentes ou menores no país, reflexões sobre medidas socioeducativas e seus limites para sua aplicação prática, e por fim, contempla considerações finais e referências bibliográficas. A metodologia usada foi estudo exploratório, recorrendo-se a pesquisa bibliográfica e análise documental.

  19. Comentários sobre as despesas públicas obrigatórias de caráter continuado sob a ótica da Lei de Responsabilidade Fiscal

    Directory of Open Access Journals (Sweden)

    André Garcia Xerez Silva

    2012-06-01

    Full Text Available O paradigma de um Estado Democrático de Direito inaugurado pela Constituição da Republica Federativa Brasileira de 1988, que incorporou o Estado Social em seu bojo, implica na compreensão das despesas públicas como pressupostos da materialização dos direitos fundamentais prometidos pelo texto constitucional. Daí surge a relevância de seu exame sob a ótica da Lei de Responsabilidade Fiscal, notadamente a respeito das despesas públicas de caráter continuado, haja vista sua imprecisão conceitual, a fim de buscar uma adequação entre seu regime legal e sua aplicação prática em  conciliação com o conceito de serviços de natureza continuada.

  20. Marx e Foucault: Um estudo sobre o papel da violência, das leis, do Estado e das normas na construção do operário disciplinado

    Directory of Open Access Journals (Sweden)

    Flávia Schilling

    1997-06-01

    Full Text Available Trata-se de um ensaio que apresenta uma leitura do Cap. XXIV do livro O Capital de Karl Marx, que tem como tema a chamada "acumulação primitiva" na formação do capitalismo. Deste texto recolhi as sugestões de Marx a respeito do papel da violência, da relação entre a violência, as leis e o Estado na construção desse "produto artificial da história moderna", o operário assalariado. Prolongo a análise marxista sobre estas relações com as propostas de Foucault sobre o papel das disciplinas e das normas

  1. A missão da interpretação no processo de aplicação da lei. Contraposição entre as lições de Hans Kelsen e Karl Larenz

    Directory of Open Access Journals (Sweden)

    Patrícia da Costa Santana

    2014-02-01

    Full Text Available O pensamento de dois teóricos será contraposto, com o propósito de fixar e explorar o poder criador da interpretação do direito. Uma particularidade da hermenêutica kelseniana é que existe uma pluralidade de significações em cada norma jurídica, rejeitando-se a possibilidade de encontro de apenas um sentido. Para Larenz, seria um erro aceitar-se que os textos jurídicos só carecem de interpretação quando obscuros; todos carecem de interpretação e da fantasia criadora do intérprete. A interpretação da lei e o desenvolvimento judicial do Direito não devem ver-se como diferentes, mas como distintos graus do mesmo processo de pensamento.

  2. REFORMULAÇÃO DA LEI 8.313/91: queda ou ressurreição da mais importante política pública cultural brasileira?

    Directory of Open Access Journals (Sweden)

    Saulo Nunes de Carvalho Almeida

    2009-01-01

    Full Text Available The present paper analyses the suggestions of possible changes in the 8.313/91 Law, known as “Lei Rouanet”. This legislation motivates culture investments in the country by allowing the use of fiscal incentives over the federal taxes on the same amount used on culture projects. This paper also analyses the common critics over the current law, and it suggests ways to improve the democracy of culture around the country, seeking ways to allow every State of the union to have a chance to access cultural projects, and not only to privilege some States, where the big companies reside. The present study is concluded emphasizing comparison between the current incentive law and the project that contains lots of modifications, comments on what should be kept and what needs to change to allow the anticipation of the Brazilian democratization of the culture.

  3. Room Temperature Thin Film Ba(x)Sr(1-x)TiO3 Ku-Band Coupled MicrostripPhase Shifters: Effects of Film Thickness, Doping, Annealing and Substrate Choice

    Science.gov (United States)

    VanKeuls, F. W.; Mueller, C. H.; Miranda, F. A.; Romanofsky, R. R.; Canedy, C. L.; Aggarwal, S.; Venkatesan, T.; Ramesh, R.; Horwitz, S.; Chang, W.

    1999-01-01

    We report on measurements taken on over twenty Ku-band coupled microstrip phase shifters (CMPS) using thin ferroelectric films of Ba(x)Sr(1-x)TiO3. This CMPS design is a recent innovation designed to take advantage of the high tunability and tolerate the high dielectric constant of ferroelectric films at Ku- and K-band frequencies. These devices are envisioned as a component in low-cost steerable beam phased area antennas, Comparisons are made between devices with differing film thickness, annealed vs unannealed, Mn-doped vs. undoped, and also substrates of LaAlO3 and MgO. A comparison between the CMPS structure and a CPW phase shifter was also made oil the same ferroelectric film.

  4. Emocionālā intelekta attīstība 16 -18 gadus veciem pusaudžiem un tā saistība ar vecāku audzināšanas stilu.

    OpenAIRE

    Poļakova, Anželika

    2011-01-01

    Šī pētījuma mērķis ir noskaidrot, vai vecāku izvēlētais audzināšanas stils ir saistīts ar emocionālā intelekta attīstību. Pētījumā piedalījās 64 respondenti: 32 sievietes no 16 līdz 18 gadiem un 32 vīrieši no 16 līdz 18 gadiem. Respondenti pārstāv dažādas sociāli ekonomiskas grupas. Tika izmantotas šādas metodes: Bar-Ona emocionālā intelekta aptauja (Bar-On Emotional Quotient Inventory (EQ-i), Bar-On, 1999) un Buri Vecāku audzināšanas stila aptauju (Buri Parental Authority Questionnaire- PAQ...

  5. Microwave absorption in X and Ku band frequency of cotton fabric coated with Ni–Zn ferrite and carbon formulation in polyurethane matrix

    International Nuclear Information System (INIS)

    Gupta, K.K.; Abbas, S.M.; Goswami, T.H.; Abhyankar, A.C.

    2014-01-01

    The present study highlights various microwave properties, i.e. reflection, transmission, absorption and reflection loss, of the coated cotton fabric [formulation: Ni–Zn ferrite (Ni 0.5 Zn 0.5 Fe 2 O 4 ) and carbon black (acetylene black) at concentrations of 30, 40, 50, 60 and70 g of ferrite and 5 g carbon in each 100 ml polyurethane] evaluated at 8–18 GHz frequency. The uniform density of filling materials in coated fabrics (dotted marks in SEM micrograph) indicates homogeneous dispersion of conducting fillers in polyurethane and the density of filling material cluster increases with increase in ferrite concentration. SEM images also show uniform coating of conducting fillers/resin system over individual fibers and interweave spaces. The important parameters governing the microwave properties of coated fabrics i.e. permittivity and permeability, S-parameters, reflection loss, etc. were studied in a HVS free space microwave measurement system. The lossy character of coated fabric is found to increase with increase of ferrite content; the ferrite content decreases the impedance and increases the permittivity and permeability values. The 1.6–1.8 mm thick coated fabric sample (40 wt% ferrite, 3 wt% carbon and 57 wt% PU) has shown about 40% absorption, 20% transmission and 40% reflectance in X (8.2–12.4 GHz) and Ku (12–18 GHz) frequency bands. The reflection loss at 13.5 GHz has shown the highest peak value (22.5 dB) due to coated sample optical thickness equal to λ/4 and more than 7.5 dB in entire Ku band. Owing to its thin and flexible nature, the coated fabric can be used as apparel in protecting human being from hazardous microwaves and also as radar camouflage covering screen in defense. - Highlights: • Ni–Zn ferrite (Ni 0.5 Zn 0.5 Fe 2 O 4 ) with acetylene black found effective coating for microwave absorption. • Coating formulation containing 40 wt% ferrite, 3 wt% carbon and 57 wt% PU offered 40% absorption, 20% transmission and 40% reflection

  6. Microwave absorption in X and Ku band frequency of cotton fabric coated with Ni–Zn ferrite and carbon formulation in polyurethane matrix

    Energy Technology Data Exchange (ETDEWEB)

    Gupta, K.K., E-mail: krishna62@rediffmail.com [Defence Materials and Stores Research and Development Establishment, Kanpur PO, GT Road, Kanpur 208013 (India); Abbas, S.M.; Goswami, T.H. [Defence Materials and Stores Research and Development Establishment, Kanpur PO, GT Road, Kanpur 208013 (India); Abhyankar, A.C. [Defence Institute of Advanced Technology( DIAT), Giri Nagar, Pune 411025 (India)

    2014-08-01

    The present study highlights various microwave properties, i.e. reflection, transmission, absorption and reflection loss, of the coated cotton fabric [formulation: Ni–Zn ferrite (Ni {sub 0.5}Zn{sub 0.5}Fe{sub 2}O{sub 4}) and carbon black (acetylene black) at concentrations of 30, 40, 50, 60 and70 g of ferrite and 5 g carbon in each 100 ml polyurethane] evaluated at 8–18 GHz frequency. The uniform density of filling materials in coated fabrics (dotted marks in SEM micrograph) indicates homogeneous dispersion of conducting fillers in polyurethane and the density of filling material cluster increases with increase in ferrite concentration. SEM images also show uniform coating of conducting fillers/resin system over individual fibers and interweave spaces. The important parameters governing the microwave properties of coated fabrics i.e. permittivity and permeability, S-parameters, reflection loss, etc. were studied in a HVS free space microwave measurement system. The lossy character of coated fabric is found to increase with increase of ferrite content; the ferrite content decreases the impedance and increases the permittivity and permeability values. The 1.6–1.8 mm thick coated fabric sample (40 wt% ferrite, 3 wt% carbon and 57 wt% PU) has shown about 40% absorption, 20% transmission and 40% reflectance in X (8.2–12.4 GHz) and Ku (12–18 GHz) frequency bands. The reflection loss at 13.5 GHz has shown the highest peak value (22.5 dB) due to coated sample optical thickness equal to λ/4 and more than 7.5 dB in entire Ku band. Owing to its thin and flexible nature, the coated fabric can be used as apparel in protecting human being from hazardous microwaves and also as radar camouflage covering screen in defense. - Highlights: • Ni–Zn ferrite (Ni{sub 0.5}Zn{sub 0.5}Fe{sub 2}O{sub 4}) with acetylene black found effective coating for microwave absorption. • Coating formulation containing 40 wt% ferrite, 3 wt% carbon and 57 wt% PU offered 40% absorption, 20

  7. ”Se on tärkeää, että sinä käyt ulkona, et istu vaan kotona ja teet erilaisia asioita.” : tutkimus harrastusten merkityksestä somalityttöjen vapaa-ajassa

    OpenAIRE

    Tikkanen, Noora

    2013-01-01

    Tämän opinnäytetyön tarkoituksena oli tutkia miten yksin Suomeen tulleet ja tälläkin hetkellä ilman perhettään asuvat somalitytöt viettävät vapaa-aikaansa, minkä merkityksen he antavat harrastuksille ja mitkä asiat vaikuttavat harrastustoimintaan osallistumiseen. Tutkimuksen tavoitteena oli löytää keinoja, joilla voitaisiin lisätä Turun ensi- ja turvakoti ry:n perheryhmäkodissa asuvien somalityttöjen harrastusaktiivisuutta, ja edistää näin heidän hyvinvointiaan ja kotoutumistaan. Tutkimus...

  8. The determinants of long-term care utilization and equity of access to care among older adults in Dong-Ku of Incheon Metropolitan city, South Korea.

    Science.gov (United States)

    Park, J M

    2005-01-01

    Under the current health care system, around three percent of the elderly remain uninsured. Based on the 2003 Dong-Ku Health Status Survey and the Aday and Andersen Access Framework, the present study examined the social and behavioral determinants of long-term care utilization and the extent to which equity in the use of long-term care services for the elderly has been achieved. The results indicate that universal health insurance system has not yielded a fully equitable distribution of services. Type of coverage and resource availability do not remain predictors of long-term care utilization. The data suggest that a universal health insurance system exists in South Korea with significant access problems for the population without insurance. Access differences also arise from obstacles in expanding the scope and level of plan benefits due to financial disparity among insurers. Health policy reforms must continue to concentrate on extending insurance coverage to the uninsured and establishing long-term insurance system for the elderly.

  9. Multi-Satellite MIMO Communications at Ku-Band and Above: Investigations on Spatial Multiplexing for Capacity Improvement and Selection Diversity for Interference Mitigation

    Directory of Open Access Journals (Sweden)

    Liolis Konstantinos P

    2007-01-01

    Full Text Available This paper investigates the applicability of multiple-input multiple-output (MIMO technology to satellite communications at the Ku-band and above. After introducing the possible diversity sources to form a MIMO matrix channel in a satellite environment, particular emphasis is put on satellite diversity. Two specific different topics from the field of MIMO technology applications to satellite communications at these frequencies are further analyzed: (i capacity improvement achieved by MIMO spatial multiplexing systems and (ii interference mitigation achieved by MIMO diversity systems employing receive antenna selection. In the first case, a single-user capacity analysis of a satellite MIMO spatial multiplexing system is presented and a useful analytical closed form expression is derived for the outage capacity achieved. In the second case, a satellite MIMO diversity system with receive antenna selection is considered, adjacent satellite cochannel interference on its forward link is studied and an analytical model predicting the interference mitigation achieved is presented. In both cases, an appropriate physical MIMO channel model is assumed which takes into account the propagation phenomena related to the frequencies of interest, such as clear line-of-sight operation, high antenna directivity, the effect of rain fading, and the slant path lengths difference. Useful numerical results obtained through the analytical expressions derived are presented to compare the performance of multi-satellite MIMO systems to relevant single-input single-output (SISO ones.

  10. Functional simian immunodeficiency virus Gag-specific CD8+ intraepithelial lymphocytes in the mucosae of SIVmac251- or simian-human immunodeficiency virus KU2-infected macaques

    International Nuclear Information System (INIS)

    Stevceva, Liljana; Moniuszko, Marcin; Alvarez, Xavier; Lackner, Andrew A.; Franchini, Genoveffa

    2004-01-01

    The vaginal and rectal mucosae are the first line of cellular immune defense to sexually transmitted human immunodeficiency virus type 1 (HIV-1) entry. Thus, intraepithelial lymphocytes (IELs) may be important in the immune response to HIV infection. Here we investigated whether functional IELs in mucosal compartments could be visualized by direct staining with a tetrameric complex specific for the simian immunodeficiency virus (SIV) immunodominant Gag epitope in either separated IEL cells or tissues of macaques infected with SIVmac251. Of the 15 Mamu-A*01-positive macaques studied here, eight were chronically infected with either SIVmac251 or simian-human immunodeficiency virus (SHIV) KU2 and the remaining seven were exposed mucosally to SIVmac251 and sacrificed within 48 h to assess the local immune response. Gag-specific CD8+ T-cells were found in separated IELs from the rectum, colon, jejunum, and vagina of most infected animals. Direct staining of tetramers also revealed their presence in intact tissue. These Gag-specific IELs expressed the activation marker CD69 and produced IFN-γ, suggesting an active immune response in this locale

  11. Problemas de los grupos *k(hi̭, *kṷ(hi̭, *t(hi̭ y *tṷ en griego

    Directory of Open Access Journals (Sweden)

    M.ª Luisa del Barrio Vega

    1990-12-01

    Full Text Available In this research the author studies a series of problems related to the evolution of the groups *k(hi̭, *kṷ(hi̭, *t(hi̭ and *tṷ in Greek. After a brief description of the palatalization process undergone by these groups and considering the different results from *t(hi̭ in the Ionic-Attic and Arcadian-Cypriot dialects which were swept twice by a wave of palatalization as well as the possible influence by analogy of the development undergone by *k(hi̭, the author examines in great depth the state of these groups at the time of the Mycenaean tablets analyzing the different values proposed for the series z- and s-. For z- an occlusive palatal and for s- an affricate articulation are considered the most likely ones. The author further suggests that the s- series followed an evolution parallel to that of the complex syllabograms of the type raz, roz, etc. Subsequently the author analyzes the graphic issues related to the evolution of the phonemic groups under study: The use of a special graphical notation in some Ionic and Pamphylian σσ/ττ in the dialects during the first millennium are due to the influence derived from the graphic representation of the state *ts. Finally the author suggests the Boeotian dialect as a starting point for the change *ts > tt, as in this dialect tt has a corresponding voiced series dd.

  12. Pusaudžu agresivitātes saistība ar vecāku audzināšanas stilu.

    OpenAIRE

    Dambe, Agnese

    2007-01-01

    Šajā darbā tiek apskatīta viena no mūsdienu būtiskākajām problēmām- pusaudžu agresivitāte. Pētījuma mērķis bija noskaidrot, vai pastāv statistiski nozīmīgas saistības starp vecāku audzināšanas stilu un pusaudžu agresivitāti. Pētījuma izlasi veido 60 pusaudži (30 jaunietes un 30 jaunieši) no pilnām ģimenēm, vecumposmā no 15-17 gadiem. Pētījumā tika izmantotas divas pētījuma metodes- A.H. Bassa (A.H. Buss)- A. Darki (A. Durkee) aptaujas anketa agresīvu reakciju noteikšanai un ...

  13. Pusaudžu tipiskās reakcijas pēc vecāku laulības šķiršanas.

    OpenAIRE

    Steļmaha, Elza

    2011-01-01

    Rezumējums Pētījuma „Pusaudžu depresija un uzvedības problēmas pēc vecāku laulības šķiršanas” mērķis bija noskaidrot kādas ir pusaudžu uzvedības un depresijas atšķirības starp šķirtajām un pilnajām ģimenēm.. Pētījuma papildus daļas mērķis bija noskaidrot kādas ir atšķirības depresijas izpausmēm un uzvedības problēmām, meitenēm un zēniem gan šķirto, gan pilno ģimeņu izlasē. Pētījumā piedalījās 60 respondenti vecuma grupā no 13-16 gadiem, 30 pusaudžiem vecāki ir šķiršanās procesā vai šķīr...

  14. Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017; Venice (Italy; October 31-November 4, 2017; Session "Neonatal Gastrointestinal Physiology and NEC"

    Directory of Open Access Journals (Sweden)

    --- Various Authors

    2017-10-01

    Full Text Available Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017; Venice (Italy; October 31-November 4, 201758th ESPR Annual Meeting, 7th International Congress of UENPS, 3rd International Congress of EFCNIORGANIZING INSTITUTIONSEuropean Society for Paediatric Research (ESPR, European Society for Neonatology (ESN, Union of European Neonatal & Perinatal Societies (UENPS, European Foundation for the Care of Newborn Infants (EFCNIORGANIZING COMMITTEELuc Zimmermann (President of ESPR, Morten Breindahl (President of ESN, Manuel Sánchez Luna (President of UENPS, Silke Mader (Chairwoman of the Executive Board and Co-Founder of EFCNISCIENTIFIC COMMITTEEVirgilio P. Carnielli (Congress President Chair, Pierre Gressens (Past Scientific President, Umberto Simeoni, Manon Benders, Neil Marlow, Ola D. Saugstad, Petra Hüppi, Agnes van den HoogenSession "Neonatal Gastrointestinal Physiology and NEC"ABS 1. DETRIMENTAL MUCOSAL EFFECT OF IBUPROFEN IN THE IMMATURE HUMAN INTESTINE • E. Tremblay, E. Ferretti, M.-P. Thibault, D. Grynspan, K.M. Burghardt, M. Bettolli, C. Babakissa, E. Levy, J.-F. Beaulieu; Research Consortium on Child Intestinal InflammationABS 2. CORRELATION BETWEEN CALPROTECTIN LEVELS IN MECONIUM AND VITAMIN D STATUS IN CORD BLOOD: ASSOCIATION WITH INTESTINAL DISTRESS DURING NEONATAL PERIOD • S.H. Park, W.H. Kim, Y.M. LeeABS 3. COMPARISON OF FECAL CALPROTECTIN LEVELS ACCORDING TO FEEDING KINDS IN VERY PRETERM INFANTS • J.H. Park, N.H. Lee, S.Y. Shin, C.S. Kim, S.L. Lee, W.M. LeeABS 4. NEONATAL MORBIDITY OF EXTREME PRETERM INFANTS BEFORE AND AFTER THE INTRODUCTION OF A DONOR HUMAN MILK BANK AT THE PERINATAL CENTER GROßHADERN • V. Lieftüchter, M. Kujawa, A. Schuze, A.W. Flemmer, S. Herber-JonatABS 5. IS NEAR INFRARED SPECTROSCOPY A RELIABLE TECHNIQUE TO MEASURE GUT PERFUSION IN PRETERM INFANTS? • J. Banerjee, T.S. Leung, N. AladangadyABS 6. EARLY BIOCHEMICAL MARKERS ASSOCIATED WITH DEVELOPMENT OF NECROTIZING

  15. LEI DE DIRETRIZES E BASES DA EDUCAÇÃO NACIONAL: O PORQUÊ E SEU CONTEXTO HISTÓRICO. LAW OF GUIDELINES AND BASIS OF NATIONAL EDUCATION: WHY AND ITS HISTORICAL CONTEXT

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    Garcia, Alessandro Barreta

    2011-11-01

    Full Text Available O Brasil é um país organizado e regido com base em normas jurídicas próprias segundo a Constituição de 1988. Sua estrutura administrativa perpassa pelos Poderes Executivo, Judiciário e Legislativo, este que por sua vez tem a missão de criar normas a fim de atender as necessidades do povo brasileiro. Como a Constituição Federal dispõe, mas não elenca com detalhes a Educação como direito social, é preciso outros documentos que garantam a dinâmica educacional, por isso a LDBEN. Este trabalho, através de revisão de literatura e documental, tem como proposta apresentar a organização do Estado, o significado de uma lei para a sociedade e discorrer sobre o motivo de termos a LDBEN 9.394/96. Este instrumento jurídico educacional também tem um registro histórico conturbado por todo processo legal no Congresso Nacional e pelo período social em que foi discutida, uma vez que a história da educação brasileira é caracterizada por fatos bem distintos fundamentados nas mudanças de governo de cada momento, por isso é apresentada uma revisão histórica de sua criação. Esta lei foi discutida durante muito tempo e, ainda sim, não conseguiu atender plenamente as necessidades iniciais da educação brasileira, exigindo muitas alterações desde sua promulgação. Consideramos a referida lei uma importante conquista que contribui na luta por uma educação melhor que apesar do repertório legal, caminha para sua legitimação.Brazil is a country organized and governed on the basis of its own legal rules according to the 1988 Constitution. Its administrative structure runs through the Executive, Judiciary and Legislature, which has the task of creating standards to meet the needs of the Brazilian people. As the Federal Constitution provides, but it does not list in detail the education as a social right, there is the need for other documents that ensure the educational dynamics, which is the LDBEN. This paper, through literature and

  16. Efeito da Lei 11.638/07 sobre o conservadorismo condicional das empresas listadas BM&FBOVESPA Efect of Law 11.638/07 on conditional conservatismo companies listed on BM&FBOVESPA

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    Luis Paulo Guimarães dos Santos

    2011-08-01

    Full Text Available A Lei nº 11.638/07 alterou, substancialmente, as normas e práticas brasileiras de contabilidade e tais mudanças poderão ter impactos significativos no conservadorismo dos resultados contábeis divulgados. Conhecer o papel do conservadorismo e seus determinantes é importante para compreender a natureza, finalidade e implicações das estimativas contábeis. Este estudo teve como objetivo investigar se a promulgação da Lei n º 11.638/07 alterou o grau de conservadorismo contábil condicional de empresas brasileiras listadas na Bovespa e BMF BOVESPA. Para tanto, procedeu-se a uma pesquisa empírico-analítica por meio de coleta de informações relativas às companhias não financeiras de capital aberto que estavam listadas na Bolsa durante o período que compreendeu o primeiro trimestre de 2005 até o terceiro trimestre de 2009, no banco de dados Economática®. O modelo de Basu foi ajustado para medir o efeito da Lei nº 11.638/07 no conservadorismo condicional. Na hipótese de conservadorismo, os ganhos refletem más notícias (retornos negativos mais rapidamente do que boas notícias (retornos positivos. Nesse modelo, a medida do conservadorismo (tratamento assimétrico dos ganhos e perdas baseia-se na extensão em que a associação lucro-retorno é mais forte durante os períodos de más notícias, em comparação com os períodos de boas notícias. Para a amostra analisada, não é possível inferir se as novas regras tiveram algum efeito sobre o grau de reconhecimento assimétrico de perdas e ganhos. Todavia, importa observar que, em função do período de tempo abrangido, os resultados apresentados são preliminares e estão limitados pelo modelo de análise de dados adotado e pelas características da amostra utilizada no estudo, não levando em consideração outros importantes aspectos relacionados ao processo de adoção das normas internacionais de contabilidade.Law nº 11.638/07 has substantially changed Brazilian accounting

  17. Young people's blood alcohol concentration and the alcohol consumption city law, Brazil Alcoholemia de jóvenes y la ley contra consumo de alcohol, Brasil Alcoolemia de jovens e lei contra o consumo de álcool

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    Raquel De Boni

    2008-12-01

    acidentes de trânsito em jovens antes e depois da implementação de lei proibindo o consumo de bebidas alcoólicas em postos de gasolina. Em Porto Alegre (RS, os jovens costumam sair à noite e dirigir até lojas de conveniência de postos de gasolina para comprar e consumir bebidas alcoólicas nos estacionamentos dentro dos postos. Os dados foram obtidos de questionários autoaplicáveis e bafômetro em duas coletas transversais realizadas com jovens, abordados em maio e julho de 2006 com amostragem intencional (n=62 e n=50, respectivamente. Não houve diferença significativa entre os grupos entrevistados. Alcoolemia >0,06% foi encontrada em 35,5% e 40% dos indivíduos antes e depois da lei, respectivamente (p=0,62. Os resultados apontam o uso pesado de álcool em ambos os grupos, inalterado pela implementação da lei.

  18. Expectativas acerca do acesso à justiça às vítimas de violência doméstica contra a mulher: os juizados de violência doméstica e familiar contra a mulher na efetivação da Lei 11.340/2006 (“Maria da Penha”

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    Mário Lúcio Garcez Calil

    2014-02-01

    Full Text Available A Lei 11.340 criou os Juizados de Violência Doméstica e Familiar contra a Mulher. Há, porém, o risco de que tais órgãos enfrentem os mesmos problemas identificados na atuação dos Juizados Especiais. O objetivo deste trabalho é discutir a aplicação da Lei 9.099/95 à violência de gênero e estudar as expectativas acerca dos Juizados de Violência Doméstica, por meio de pesquisa bibliográfica e jurisprudencial. Justifica-se o trabalho, pois a violência doméstica é um problema social grave. Conclui-se que a atuação dos Juizados de Violência deve ocorrer de forma diversa do processo comum, levando em conta a natureza social do fenômeno.

  19. Esporte de alto rendimento: produção social da modernidade - o caso do vôlei de praia High performance sports: a social production of modernity - the beach volleyball model

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    Marília Maciel Costa

    2007-04-01

    Full Text Available O estudo, inicialmente, apresenta a inserção do esporte nos tempos modernos com o objetivo de resgatar e discutir a estruturação da produção do esporte de alto rendimento no Brasil. A modalidade vôlei de praia serviu de modelo empírico e procurou-se verificar, durante o levantamento dos dados coletados, a forma e os valores que predominavam no ambiente social em que se desenvolvia essa modalidade. Para isso, foram focalizadas as relações que se processavam no decorrer de sua estruturação e procurou-se verificar o grau de influência que elas sofreram diante das mudanças estruturais capitalistas e de novas situações conjunturais. Concluiu-se que o vôlei de praia brasileiro, na verdade, mesmo apresentando problemas inerentes à própria condição de esporte de alto rendimento, e diante das muitas adversidades que enfrenta no cenário social nacional, tem ocorrido com base nos valores ditados pelo "profissionalismo", suplantando os valores de uma cultura "amadorística" e tradicional, predominante no universo esportivo nacional.The study examines sports in modern times. The objective of this was to retrieve and discuss the structuring of high performance sports production in Brazil. Beach volleyball served as a model. During the data collection process, aim was made to ascertain the forms and values that are predominant in the social environment of beach volleyball. For this, focus was placed on the relationships that developed during the structuring process and attempt was made to verify how such relationships were influenced by the capitalist-structural changes and the new settings that resulted therefrom. The study concluded that despite having problems that are inherent to the sport's being highly performance-oriented, and in light of many adversities faced in the national scenario, Brazilian beach volleyball is based on the values dictated by professionalism that overcome values of the amateur-like and traditional culture that

  20. Gestão dos gastos de pessoal na administração pública brasileira: avanços após a implementação da Lei de Responsabilidade Fiscal

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    Josenildo dos Santos

    2007-12-01

    Full Text Available O objetivo deste estudo consistiu em analisar os impactos gerados pela Lei de Responsabilidade Fiscal, no que tange ao comprometimento da receita corrente com as despesas com pessoal, em três anos de sua vigência, ou seja, comparando-se os gastos dos exercícios de 1999 com 2001 e 1999 com 2002. Utilizou-se uma amostra de 86 municípios do Estado da Paraíba, buscando verificar a existência de diferenças significativas entre os níveis de comprometimento das Receitas Correntes Líquidas com gastos de pessoal a partir do teste não-paramétrico de Mann-Whitney. Concluiu-se que quando se analisa 1999 com relação a 2001 percebe-se que o esforço para redução de despesa com pessoal ainda não é estatisticamente perceptível. No entanto, quando se analisa 1999 com relação a 2002, infere-se que houve diminuição significativa, do ponto de vista da estatística da participação das despesas com pessoal na receita corrente de 2002 em relação a 1999. Palavras Chaves: Lei de Responsabilidade Fiscal, despesas com pessoal e receita corrente líquida. Abstract The aim of this study is to analyse the impacts generated by the Fiscal Responsibility Law, with reference to the commitment of the current revenue with expenditures with staff, in three years, comparing the expenses of the exercises of 1999 with those of 2001 and the ones of 1999 with those of 2002. A sample of 86 cities of the State of Paraíba was used with an attempt to verify the existence of significant differences between the levels of commitment of the Liquid Current Revenues with expenses with staff from the Mann-Whitney’s nonparametric tests. It was concluded that when 1999 is compared to 2001, one can notice that the effort for the reduction of expenditure with staff is still not statistically perceivable. However, when 1999 is observed in comparison to 2002, it is visible that there was a significant reduction in the participation of expenditures with staff in the current