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Sample records for kostyrko tibor alt

  1. Educational Insights of the Economist: Tibor Scitovsky on Education, Production and Creative Consumption

    Science.gov (United States)

    Gilead, Tal

    2013-01-01

    In recent decades education is increasingly perceived as an instrument for generating economic growth and enhancing production. Unexpectedly, however, many prominent economists, throughout history, have rejected this view of education. This article examines the grounds on which Tibor Scitovsky, who was one of the leading economists of twentieth…

  2. Alanine transaminase (ALT) blood test

    Science.gov (United States)

    ... gov/ency/article/003473.htm Alanine transaminase (ALT) blood test To use the sharing features on this page, please enable JavaScript. The alanine transaminase (ALT) blood test measures the level of the enzyme ALT in ...

  3. Editorial ALT-J non-electronica

    Directory of Open Access Journals (Sweden)

    Gabriel Jacobs

    1997-12-01

    Full Text Available The ALT Executive Committee has discussed on a number of occasions the question of making ALT-J wholly available in electronic form on our Web site (at present only the editorial and abstracts of papers appear, and even of turning it into a full-blown electronic journal. I have gently but consistently opposed this move, on occasions to the intense irritation of some of my fellow members, and always at the risk of appearing to be a Luddite. Explicitly ('Who, if not we as learning technologists, should be in the forefront of the soon-to-happen electronic-journal revolution?' and implicitly ('It is estimated that within two years, paper-based journals will be considered the dinosaurs of the academic world', I have increasingly come under pressure to accede to an apparently unstoppable, apparently imminent change in the method and form of scholarly publication. I set out here my reasons for my continued resistance.

  4. ALT Strategy, February 2017 - January 2020

    OpenAIRE

    Deepwell, Maren

    2017-01-01

    The Association for Learning Technology (ALT) represents individual and organisational Members from all sectors and parts of the UK. Our Membership includes practitioners, researchers and policy makers with an interest in Learning Technology. Our community grows more diverse as Learning Technology has become recognised as a fundamental part of learning, teaching and assessment. Our charitable objective is "to advance education through increasing, exploring and disseminating knowledge in t...

  5. Die Altäre von Selinunt

    OpenAIRE

    Voigts, Clemens

    2014-01-01

    In der Dissertation wurden die Altäre von Selinunt, einer griechischen Kolonie auf Sizilien, mit den Methoden der Bauforschung untersucht. Die neun behandelten Brandopferaltäre sind monumentale Quaderbauten, die bis zu 20 m Länge erreichen. Sie stammen aus der Blütezeit Selinunts, dem 6. und 5. Jh. v. Chr. Die Bauten waren bereits im 19. und 20. Jh. freigelegt worden und wurden nun in Bauaufnahmen dokumentiert, zeichnerisch rekonstruiert und zeitlich eingeordnet. Dabei ließ sich an ihnen eine...

  6. ALT-I pump limiter experiments

    International Nuclear Information System (INIS)

    Goebel, D.M.; Conn, R.W.; Campbell, G.A.

    1987-09-01

    Results from the ALT-I pump limiter experiments in TEXTOR are presented. ALT-I has demonstrated control of the plasma density in a high recycling tokamak by pumping up to 15% of the core efflux. The closed pump limiter designs with restricted entrance geometries to reduce the backflow of neutral gas to the plasma remove over 50% of the ion flux incident on the collection slot. Up to 80% of the entrance ion flux is removed when the edge electron temperature is less than 10 eV and plasma-neutral gas interactions are minimized inside the limiter. Results from a 3-D Monte Carlo neutral gas transport code agree closely with these experimental results. The compound curvature of the head is found to distribute the heat over the surface as predicted in the original designs. Impurity removal experiments demonstrate that significant helium exhaust can be achieved with a pump limiter. During ohmic heating in TEXTOR, the energy and particle confinement times are proportional to the line averaged core density. With ICRH auxiliary heating, tau/sub E/ follow L-mode scaling independent of particle removal by the pump limiter. Pump limiter operation does not directly modify the SOL plasma density and electron temperature, but controls the core plasma density by changing the global recycling at the boundary. The global particle confinement, the particle flux to the limiter, and the edge electron temperature follow the changes in the core density and auxiliary heating power. 25 refs

  7. ALT Blood Test: MedlinePlus Lab Test Information

    Science.gov (United States)

    ... K. Brunner & Suddarth's Handbook of Laboratory and Diagnostic Tests. 2 nd Ed, Kindle. Philadelphia: Wolters Kluwer Health, Lippincott Williams & Wilkins; c2014. Alanine Aminotransferase (ALT); p. 31. Lab ...

  8. Association of ALT and the metabolic syndrome among Mexican children.

    Science.gov (United States)

    Elizondo-Montemayor, Leticia; Ugalde-Casas, Patricia A; Lam-Franco, Lorena; Bustamante-Careaga, Humberto; Serrano-González, Mónica; Gutiérrez, Norma G; Martínez, Ubaldo

    2014-01-01

    Nonalcoholic fatty liver disease (NAFLD) is emerging as a component of the metabolic syndrome (MetS); Hispanics being particularly predisposed. Alanine aminotransferase (ALT) is considered a marker of NAFLD. The aim of this study was to determine the prevalence and associations between ALT elevations and MetS in normal-weight, overweight and obese Mexican children and adolescents, since data in Mexico is scarce. Body mass index (BMI), waist circumference (WC), percentage body fat, blood pressure, glucose, lipid profiles, ALT and aspartate aminotransferase (AST) were measured in 236, 6-12yo normal-weight, overweight and obese Mexicans from eight public schools. The results showed that elevated ALT (>40 IU/L) was found in 17.7% of the obese and overweight population, with no gender difference. The prevalence of elevated ALT increased linearly across BMI categories (p = 0.001), from 0.0% for the normal-weight group (95%CI 0.0-€“8.0) to 22.4% for the obese one (95%CI 16.2-€“30.2). AST/ALT ratio obese one. The prevalence of MetS was strongly associated with elevated ALT (p = 0.002), 50% in the elevated ALT group (95%CI 34.1-€“65.9) and 24.1% in the normal ALT one (95%CI 18.1-€“31.3). There was also a strong association between MetS and an AST/ALT ratio obese children. © 2014 Asian Oceanian Association for the Study of Obesity . Published by Elsevier Ltd. All rights reserved.

  9. Kui kapital veab alt, siis turvaliselt / Aleksander Tsapov

    Index Scriptorium Estoniae

    Tsapov, Aleksander

    2006-01-01

    Kuraatorinäitus "Kapital (see veab meid alt)" Tallinna Kunstihoones. Kuraator Simon Sheikh. Fia-Stina Sandlundi, Katya Sanderi, Oliver Ressleri, Ashley Hunti ja Susan Kelly&Stephen Mortoni töödest näitusel

  10. PISCES and ALT-II: Juelich PSI papers

    International Nuclear Information System (INIS)

    Conn, R.W.; Hirooka, Y.; LaBombard, B.

    1988-08-01

    This publication comprises papers from the PISCES and ALT-II Programs at UCLA which were presented at the International Plasma Surface Interactions Meeting held in Juelich, FRG, on May 2-6, 1988. A list of publications from the PISCES and ALT-II contained in this report are: Deuterium pumping and erosion behavior of selected graphite materials under high flux plasma bombardment in PISCES; Erosion and redeposition behavior of selected NET-candidate materials under high-flux hydrogen, deuterium plasma bombardment in PISCES; Presheath profiles in simulated tokamak edge plasmas; Boundary asymmetries and plasma flow to the ALT-II toroidal belt pump limiter; ALT-II toroidal belt pump limiter performance in TEXTOR; and An in-situ spectroscopic erosion yield measurement with applications to sputtering and surface morphology alterations

  11. Army AL&T, July-September 2008

    Science.gov (United States)

    2008-09-01

    Northern Region — Wanda Reed (PCO), Joann Langston (PARC), Debbie Emerson (Alt. to PARC) Southern Region — Julie Silva (PCO), Carol Lowman (Direc- tor/PARC...Charles Jaber (PCO), Roger Engebretson, (Director/PARC), Sharon Oishi (Alt. to PARC) U.S. Army Contracting Command, Southwest Asia — Carol Estes (PCO...Robyn Villafranco, Margarita Ramirez, Diana Fernandez, Donna Reed, Michely Walton, Elisa Mendez , Cynariah Wilkins, Deinor Bolanos, Belinda Kent

  12. ELEVATED ALT AND AST IN AN ASYMPTOMATIC PERSON

    Directory of Open Access Journals (Sweden)

    KEW ST

    2009-01-01

    Full Text Available -Abnormal liver function test with raised alanine aminotransferase (ALT and raised aspartate aminotransferase (AST are commonly seen in primary care setting. -Chronic alcohol consumption, drugs, non-alcoholic steatohepatitis (NASH and chronic viral hepatitis are common causes associated with raised ALT and AST. -In chronic viral hepatitis, the elevation of liver enzyme may not correlate well with the degree of liver damage. -Non-hepatic causes of raised ALT and AST include polymyositis, acute muscles injury, acute myocardial infarction and hypothyroidism. -In the primary care setting, the doctor should obtain a complete history regarding the risk factors for viral hepatitis, substance abuse and request investigations accordingly. -Suspected chronic viral hepatitis and liver cirrhosis are best referred to hepatologist for further management.

  13. ALT-II armor tile design for upgraded TEXTOR operation

    International Nuclear Information System (INIS)

    Newberry, B.L.; McGrath, R.T.; Watson, R.D.; Kohlhaas, W.; Finken, K.H.

    1994-01-01

    The upgrade of the TEXTOR tokamak at KFA Juelich was recently completed. This upgrade extended the TEXTOR pulse length from 5 seconds to 10 seconds. The auxiliary heating was increased to a total of 8.0 MW through a combination of neutral beam injection and radio frequency heating. Originally, the inertially cooled armor tiles of the full toroidal belt Advanced Limiter Test -- II (ALT-II) were designed for a 5-second operation with total heating of 6.0 MW. The upgrade of TEXTOR will increase the energy deposited per pulse onto the ALT-II by about 300%. Consequently, the graphite armor tiles for the ALT-II had to be redesigned to avoid excessively high graphite armor surface temperatures that would lead to unacceptable contamination of the plasma. This redesign took the form of two major changes in the ALT-II armor tile geometry. The first design change was an increase of the armor tile thermal mass, primarily by increasing the radial thickness of each tile from 17 mm to 20 mm. This increase in the radial tile dimension reduces the overall pumping efficiency of the ALT-II pump limiter by about 30%. The reduction in exhaust efficiency is unfortunate, but could be avoided only by active cooling of the ALT-II armor tiles. The active cooling option was too complicated and expensive to be considered at this time. The second design change involved redefining the plasma facing surface of each armor tile in order to fully utilize the entire surface area. The incident charged particle heat flux was distributed uniformly over the armor tile surfaces by carefully matching the radial, poloidal and toroidal curvature of each tile to the plasma flow in the TEXTOR boundary layer. This geometry redefinition complicates the manufacturing of the armor tiles, but results in significant thermal performance gains. In addition to these geometry upgrades, several material options were analyzed and evaluated

  14. ALT-II armor tile design for upgraded TEXTOR operation

    International Nuclear Information System (INIS)

    Newberry, B.L.; McGrath, R.T.; Watson, R.D.

    1994-01-01

    The upgrade of the TEXTOR tokamak at KFA Julich will be completed in the spring of 1994. The upgrade will extend the TEXTOR pulse length from 5 seconds to 10 seconds. The auxiliary heating systems are also scheduled to be upgraded so that eventually a total of 8.0 MW auxiliary heating will be available through a combination of neutral beam injection and radio frequency heating. Originally, the inertially cooled armor tiles on the full toroidal belt Advanced Limiter Test - II (ALT-II) were designed for 5-second operation with a total heating power of 6.0 MW. The upgrade of TEXTOR will increase the energy deposited per pulse onto ALT-II by more than 300%. Consequently, the graphite armor tiles for ALT-II had to be redesigned in order to increase their thermal inertia and, thereby, avoid excessively high graphite armor surface temperatures that would lead to unacceptable contamination of the plasma. The armor tile thermal inertia had been increase primarily by expanding the radial thickness of the tiles from 17 mm to 20 mm. This increase in radial tile dimension will reduce the overall pumping efficiency of the ALT-II pump limiter by about 30%. The final armor tile design was a compromise between increasing the power handling capability and reducing the particle exhaust efficiency of ALT-II. The reduction in exhaust efficiency is unfortunate, but could only be avoided by active cooling of the ALT-II armor tiles. The active cooling option was too complicated and expensive to be considered at this time

  15. ALT-II toroidal belt limiter biasing experiments on TEXTOR

    International Nuclear Information System (INIS)

    Doerner, R.; Boedo, J.A.; Gray, D.S.

    1991-01-01

    Edge electric fields have been related to H-mode-like behaviour. The experiments reported here are an attempt to control the SOL profiles by electrostatic biasing of the full toroidal-belt limiter ALT-II. The specific goals are: influencing the edge particle flows, particle removal, power deposition and the global confinement. The ALT-II pump limiter is a full toroidal belt located at 45 o below the outer midplane and consisting of eight graphite covered blades which can be independently biased. Particle scoops located behind the limiter neutralize and direct the incoming plasma into the pumping ducts. (author) 5 refs., 3 figs

  16. Peek ja Lepik soovisid varade aresti alt vabastamist

    Index Scriptorium Estoniae

    2005-01-01

    LHV endine töötaja Oliver Peek väidab, et tema vastu esitatud süüdistused on alusetud ja tõendamata ning nõuab oma varade aresti alt vabastamist. Kristjan Lepingu kohtuasja arutamine lükati edasi 21. detsembrile. Endiselt käib uurimine, kui palju väidetavalt teabevargusega raha teeniti

  17. Presentation and demonstration at Alt-i-lab 2005

    NARCIS (Netherlands)

    Tattersall, Colin

    2005-01-01

    These documents were used to accompany the Learning Design presentation and demonstration at Alt-i-lab 2005. The slides were shown during a plenary session describing the interoperability demo. The scenario was used to guide the demonstration process, and the UNFOLD handout was used to illustrate

  18. Saccharomyces cerevisiae Differential Functionalization of Presumed ScALT1 and ScALT2 Alanine Transaminases Has Been Driven by Diversification of Pyridoxal Phosphate Interactions

    Directory of Open Access Journals (Sweden)

    Erendira Rojas-Ortega

    2018-05-01

    Full Text Available Saccharomyces cerevisiae arose from an interspecies hybridization (allopolyploidiza-tion, followed by Whole Genome Duplication. Diversification analysis of ScAlt1/ScAlt2 indicated that while ScAlt1 is an alanine transaminase, ScAlt2 lost this activity, constituting an example in which one of the members of the gene pair lacks the apparent ancestral physiological role. This paper analyzes structural organization and pyridoxal phosphate (PLP binding properties of ScAlt1 and ScAlt2 indicating functional diversification could have determined loss of ScAlt2 alanine transaminase activity and thus its role in alanine metabolism. It was found that ScAlt1 and ScAlt2 are dimeric enzymes harboring 67% identity and intact conservation of the catalytic residues, with very similar structures. However, tertiary structure analysis indicated that ScAlt2 has a more open conformation than that of ScAlt1 so that under physiological conditions, while PLP interaction with ScAlt1 allows the formation of two tautomeric PLP isomers (enolimine and ketoenamine ScAlt2 preferentially forms the ketoenamine PLP tautomer, indicating a modified polarity of the active sites which affect the interaction of PLP with these proteins, that could result in lack of alanine transaminase activity in ScAlt2. The fact that ScAlt2 forms a catalytically active Schiff base with PLP and its position in an independent clade in “sensu strictu” yeasts suggests this protein has a yet undiscovered physiological function.

  19. Saccharomyces cerevisiae Differential Functionalization of Presumed ScALT1 and ScALT2 Alanine Transaminases Has Been Driven by Diversification of Pyridoxal Phosphate Interactions

    Science.gov (United States)

    Rojas-Ortega, Erendira; Aguirre-López, Beatriz; Reyes-Vivas, Horacio; González-Andrade, Martín; Campero-Basaldúa, Jose C.; Pardo, Juan P.; González, Alicia

    2018-01-01

    Saccharomyces cerevisiae arose from an interspecies hybridization (allopolyploidiza-tion), followed by Whole Genome Duplication. Diversification analysis of ScAlt1/ScAlt2 indicated that while ScAlt1 is an alanine transaminase, ScAlt2 lost this activity, constituting an example in which one of the members of the gene pair lacks the apparent ancestral physiological role. This paper analyzes structural organization and pyridoxal phosphate (PLP) binding properties of ScAlt1 and ScAlt2 indicating functional diversification could have determined loss of ScAlt2 alanine transaminase activity and thus its role in alanine metabolism. It was found that ScAlt1 and ScAlt2 are dimeric enzymes harboring 67% identity and intact conservation of the catalytic residues, with very similar structures. However, tertiary structure analysis indicated that ScAlt2 has a more open conformation than that of ScAlt1 so that under physiological conditions, while PLP interaction with ScAlt1 allows the formation of two tautomeric PLP isomers (enolimine and ketoenamine) ScAlt2 preferentially forms the ketoenamine PLP tautomer, indicating a modified polarity of the active sites which affect the interaction of PLP with these proteins, that could result in lack of alanine transaminase activity in ScAlt2. The fact that ScAlt2 forms a catalytically active Schiff base with PLP and its position in an independent clade in “sensu strictu” yeasts suggests this protein has a yet undiscovered physiological function. PMID:29867852

  20. ALT-I pump limiter results on TEXTOR

    International Nuclear Information System (INIS)

    Dippel, K.H.; Finken, K.H.; Guthrie, S.E.; Malinowski, M.E.; Pontau, A.E.; Campbell, G.A.; Goebel, D.M.; Conn, R.W.

    1985-01-01

    The ALT-I pump limiter is used to control hydrogen fluxes from the TEXTOR tokamak. The performance of two different modules, the open fixed geometry (FG) and the closed variable geometry (VG) is discussed. In unpumped scoop limiter operation, the pressure in the ALT-I chamber increases to 3x10 -4 torr(FG) and 2x10 -3 torr(VG). With pumping, the fraction of particles incident on the neutralizer plate that is removed is 25-50%(FG) and 50-80%(VG). These removed particles are estimated to be 2-4(8)%(FG) and 6-13%(VG) of the total plasma outflux (Nsub(e)/tausub(p)). The collection of helium from the plasma using the FG module is approximately half as effective as hydrogen collection. The higher particle removal efficiency for the VG module is attributed to lower neutral backstreaming. (author)

  1. Alternative Liquid Fuels Simulation Model (AltSim).

    Energy Technology Data Exchange (ETDEWEB)

    Williams, Ryan; Baker, Arnold Barry; Drennen, Thomas E.

    2009-12-01

    The Alternative Liquid Fuels Simulation Model (AltSim) is a high-level dynamic simulation model which calculates and compares the production and end use costs, greenhouse gas emissions, and energy balances of several alternative liquid transportation fuels. These fuels include: corn ethanol, cellulosic ethanol from various feedstocks (switchgrass, corn stover, forest residue, and farmed trees), biodiesel, and diesels derived from natural gas (gas to liquid, or GTL), coal (coal to liquid, or CTL), and coal with biomass (CBTL). AltSim allows for comprehensive sensitivity analyses on capital costs, operation and maintenance costs, renewable and fossil fuel feedstock costs, feedstock conversion ratio, financial assumptions, tax credits, CO{sub 2} taxes, and plant capacity factor. This paper summarizes the structure and methodology of AltSim, presents results, and provides a detailed sensitivity analysis. The Energy Independence and Security Act (EISA) of 2007 sets a goal for the increased use of biofuels in the U.S., ultimately reaching 36 billion gallons by 2022. AltSim's base case assumes EPA projected feedstock costs in 2022 (EPA, 2009). For the base case assumptions, AltSim estimates per gallon production costs for the five ethanol feedstocks (corn, switchgrass, corn stover, forest residue, and farmed trees) of $1.86, $2.32, $2.45, $1.52, and $1.91, respectively. The projected production cost of biodiesel is $1.81/gallon. The estimates for CTL without biomass range from $1.36 to $2.22. With biomass, the estimated costs increase, ranging from $2.19 per gallon for the CTL option with 8% biomass to $2.79 per gallon for the CTL option with 30% biomass and carbon capture and sequestration. AltSim compares the greenhouse gas emissions (GHG) associated with both the production and consumption of the various fuels. EISA allows fuels emitting 20% less greenhouse gases (GHG) than conventional gasoline and diesels to qualify as renewable fuels. This allows several of the

  2. Rescue excavations on Alt-Laari settlement site, Tartumaa / Anti Lillak, Heiki Valk

    Index Scriptorium Estoniae

    Lillak, Anti

    2009-01-01

    Alt-Laari linnusasula tekkis nähtavasti rooma rauaajal. Kui Alt-Laari linnus oli kasutused arvatavasti I aastatuhandest II aastatuhandeni pKr. siis asula kestis edasi keskajal ning jäeti maha hiljemalt 14. sajandil

  3. A gene expression signature classifying telomerase and ALT immortalization reveals an hTERT regulatory network and suggests a mesenchymal stem cell origin for ALT

    DEFF Research Database (Denmark)

    Lafferty-Whyte, K; Cairney, C J; Will, M B

    2009-01-01

    Telomere length is maintained by two known mechanisms, the activation of telomerase or alternative lengthening of telomeres (ALT). The molecular mechanisms regulating the ALT phenotype are poorly understood and it is unknown how the decision of which pathway to activate is made at the cellular le......TERT in different tumour types and normal tissues. We also show evidence to suggest a novel mesenchymal stem cell origin for ALT immortalization in cell lines and mesenchymal tissues....

  4. 21 CFR 862.1030 - Alanine amino transferase (ALT/SGPT) test system.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Alanine amino transferase (ALT/SGPT) test system... Test Systems § 862.1030 Alanine amino transferase (ALT/SGPT) test system. (a) Identification. An alanine amino transferase (ALT/SGPT) test system is a device intended to measure the activity of the...

  5. DSLR Double Star Astrometry Using an Alt-Az Telescope

    Science.gov (United States)

    Frey, Thomas; Haworth, David

    2014-07-01

    The goal of this project was to determine if the double star's angular separation and position angle measurements could be successfully measured with a motor driven, alt-azimuth Dobsonian-mounted Newtonian telescope (without a field rotator), and a digital single-lens reflex (DSLR) camera. Additionally, the project was constrained by using as much existing equipment as much as possible, including an Apple MacBook Pro laptop and a Canon T2i camera. This project was additionally challenging because the first author had no experience with astrophotography.

  6. The human CTC1/STN1/TEN1 complex regulates telomere maintenance in ALT cancer cells

    Energy Technology Data Exchange (ETDEWEB)

    Huang, Chenhui; Jia, Pingping; Chastain, Megan; Shiva, Olga; Chai, Weihang, E-mail: wchai@wsu.edu

    2017-06-15

    Maintaining functional telomeres is important for long-term proliferation of cells. About 15% of cancer cells are telomerase-negative and activate the alternative-lengthening of telomeres (ALT) pathway to maintain their telomeres. Recent studies have shown that the human CTC1/STN1/TEN1 complex (CST) plays a multi-faceted role in telomere maintenance in telomerase-expressing cancer cells. However, the role of CST in telomere maintenance in ALT cells is unclear. Here, we report that human CST forms a functional complex localizing in the ALT-associated PML bodies (APBs) in ALT cells throughout the cell cycle. Suppression of CST induces telomere instabilities including telomere fragility and elevates telomeric DNA recombination, leading to telomere dysfunction. In addition, CST deficiency significantly diminishes the abundance of extrachromosomal circular telomere DNA known as C-circles and t-circles. Suppression of CST also results in multinucleation in ALT cells and impairs cell proliferation. Our findings imply that the CST complex plays an important role in regulating telomere maintenance in ALT cells. - Highlights: • CST localizes at telomeres and ALT-associated PML bodies in ALT cells throughout the cell cycle. • CST is important for promoting telomeric DNA replication in ALT cells. • CST deficiency decreases ECTR formation and increases T-SCE. • CST deficiency impairs ALT cell proliferation and results in multinucleation.

  7. Activation of the ALT pathway for telomere maintenance can affect other sequences in the human genome.

    Science.gov (United States)

    Jeyapalan, Jennie N; Varley, Helen; Foxon, Jenny L; Pollock, Raphael E; Jeffreys, Alec J; Henson, Jeremy D; Reddel, Roger R; Royle, Nicola J

    2005-07-01

    Immortal human cells maintain telomere length by the expression of telomerase or through the alternative lengthening of telomeres (ALT). The ALT mechanism involves a recombination-like process that allows the rapid elongation of shortened telomeres. However, it is not known whether activation of the ALT pathway affects other sequences in the genome. To address this we have investigated, in ALT-expressing cell lines and tumours, the stability of tandem repeat sequences known to mutate via homologous recombination in the human germline. We have shown extraordinary somatic instability in the human minisatellite MS32 (D1S8) in ALT-expressing (ALT+) but not in normal or telomerase-expressing cell lines. The MS32 mutation frequency varied across 15 ALT+ cell lines and was on average 55-fold greater than in ALT- cell lines. The MS32 minisatellite was also highly unstable in three of eight ALT+ soft tissue sarcomas, indicating that somatic destabilization occurs in vivo. The MS32 mutation rates estimated for two ALT+ cell lines were similar to that seen in the germline. However, the internal structures of ALT and germline mutant alleles are very different, indicating differences in the underlying mutation mechanisms. Five other hypervariable minisatellites did not show elevated instability in ALT-expressing cell lines, indicating that minisatellite destabilization is not universal. The elevation of MS32 instability upon activation of the ALT pathway and telomere length maintenance suggests there is overlap between the underlying processes that may be tractable through analysis of the D1S8 locus.

  8. Editorial: a new direction for ALT-J

    Directory of Open Access Journals (Sweden)

    Gráinne Conole

    2003-12-01

    Full Text Available The Association for Learning Technology celebrated its tenth anniversary this year and it can now be said that learning technology is a recognized research field, with a growing body of researchers and associated conferences and journals. Over the past two years as an editorial team we have undertaken a review of the position of ALT-J in relation to other journals in the area and considered the nature and scope of the papers we publish. We continue to expand our list of referees and have provided them with more detailed review forms to help guide them when considering recommendations on submissions and to encourage detailed, critical (and hopefully! helpful feedback to authors. We would like to take this opportunity to thank all the referees for their involvement and commitment to the journal and for their continued work on refereeing papers. As part of the review process we will be moving to a new publisher, Taylor and Francis, commencing with Volume 12; this is, in part, driven by a desire to increase our international profile and readership, as well as seeking to have a better online presence including electronic access to all papers. We are, after all, a research journal on learning technologies! We are looking forward to taking the journal forward with Taylor and Francis but would also like to take this opportunity to thank our current publisher, University of Wales Press, for all their support and professional work over the years; it has been very good working with them.

  9. Preliminary design analysis of the ALT-II limiter for TEXTOR

    International Nuclear Information System (INIS)

    Koski, J.A.; Boyd, R.D.; Kempka, S.M.; Romig, A.D. Jr.; Smith, M.F.; Watson, R.D.; Whitley, J.B.; Conn, R.W.; Grotz, S.P.

    1983-01-01

    Installation of a large toroidal belt pump limiter, Advanced Limiter Test II (ALT-II), on the TEXTOR tokamak at Juelich, FRG is anticipated for early 1986. This paper discusses the preliminary mechanical design and materials considerations undertaken as part of the feasibility study phase for ALT-II

  10. Production of the Allergenic Protein Alt a 1 by Alternaria Isolates from Working Environments

    Directory of Open Access Journals (Sweden)

    Justyna Skóra

    2015-02-01

    Full Text Available The aim of the study was to evaluate the ability of Alternaria isolates from workplaces to produce Alt a 1 allergenic protein, and to analyze whether technical materials (cellulose, compost, leather present within the working environment stimulate or inhibit Alt a 1 production (ELISA test. Studies included identification of the isolated molds by nucleotide sequences analyzing of the ITS1/ITS2 regions, actin, calmodulin and Alt a 1 genes. It has been shown that Alternaria molds are significant part of microbiocenosis in the archive, museum, library, composting plant and tannery (14%–16% frequency in the air. The presence of the gene encoding the Alt a 1 protein has been detected for the strains: Alternaria alternata, A. lini, A. limoniasperae A. nobilis and A. tenuissima. Environmental strains produced Alt a 1 at higher concentrations (1.103–6.528 ng/mL than a ATCC strain (0.551–0.975 ng/mL. It has been shown that the homogenization of the mycelium and the use of ultrafiltration allow a considerable increase of Alt a 1 concentration. Variations in the production of Alt a 1 protein, depend on the strain and extraction methods. These studies revealed no impact of the technical material from the workplaces on the production of Alt a 1 protein.

  11. PPARα regulates the hepatotoxic biomarker alanine aminotransferase (ALT1) gene expression in human hepatocytes

    International Nuclear Information System (INIS)

    Thulin, Petra; Rafter, Ingalill; Stockling, Kenneth; Tomkiewicz, Celine; Norjavaara, Ensio; Aggerbeck, Martine; Hellmold, Heike; Ehrenborg, Ewa; Andersson, Ulf; Cotgreave, Ian; Glinghammar, Bjoern

    2008-01-01

    In this work, we investigated a potential mechanism behind the observation of increased aminotransferase levels in a phase I clinical trial using a lipid-lowering drug, the peroxisome proliferator-activated receptor (PPAR) α agonist, AZD4619. In healthy volunteers treated with AZD4619, serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities were elevated without an increase in other markers for liver injury. These increases in serum aminotransferases have previously been reported in some patients receiving another PPARα agonist, fenofibrate. In subsequent in vitro studies, we observed increased expression of ALT1 protein and mRNA in human hepatocytes after treatment with fenofibric acid. The PPAR effect on ALT1 expression was shown to act through a direct transcriptional mechanism involving at least one PPAR response element (PPRE) in the proximal ALT1 promoter, while no effect of fenofibrate and AZD4619 was observed on the ALT2 promoter. Binding of PPARs to the PPRE located at - 574 bp from the transcriptional start site was confirmed on both synthetic oligonucleotides and DNA in hepatocytes. These data show that intracellular ALT expression is regulated by PPAR agonists and that this mechanism might contribute to increased ALT activity in serum

  12. Pattern of AST and ALT changes in Relation to Hemolysis in sickle cell Disease

    Directory of Open Access Journals (Sweden)

    K. Nsiah

    2011-01-01

    Full Text Available Background Elevated aminotransferase levels are commonly associated with compromised hepatic integrity from various insults. In sickle cell disease, aspartate transaminase (AST is also released via intravascular hemolysis. This study was done to determine the pattern of changes in AST and alanine transaminase (ALT, in particular the AST:ALT ratio, and to relate these to the hemolytic state, which we consider to be more important than hepatic and cardiac dysfunction in some individuals with sickle cell disease. Methods Serum aminotransferase levels were measured in 330 subjects with sickle cell disease, as well as hemoglobin, reticulocytes, and lactate dehydrogenase. The AST:ALT ratio was designated as a hemolytic marker, and simple and multivariate regression analyses were carried out between this ratio and other hemolytic markers. Results Mean AST and ALT levels were 48.24 % 27.78 and 26.48 % 22.73 U/L, respectively. However, for 49 subjects without sickle cell disease, mean AST and ALT levels were the same, ie, 23.0 U/L. In the subjects with sickle cell disease, the increases in AST levels were far higher than for ALT, supporting its release via intravascular hemolysis. In 95.8% of the subjects with sickle cell disease, the AST:ALT ratio was > 1, but our results did not suggest overt malfunctioning of the liver and heart in the majority of subjects. Conclusion Regression analyses support the use of the AST:ALT ratio as a hemolytic marker, because it has an inverse association with the hemoglobin level. Whether in steady state or in crisis, provided hepatic and cardiac integrity has not been compromised, subjects with sickle cell disease would have higher AST levels due to the hemolytic nature of the condition. This is the first report highlighting the AST:ALT ratio in sickle cell disease.

  13. Alte Harfe. Vollständige Sammlung alter estnischer Volkslieder : Vorrede / Jakob Hurt

    Index Scriptorium Estoniae

    Hurt, Jakob, 1839-1907

    2005-01-01

    Eessõna rmt. : Hurt, Jakob. Vana kannel. 1. kogu : täieline kogu vanu eesti rahvalaulusid = Alte Harfe : vollständige Sammlung alter estnischen Volkslieder. Tartu, 1875-1886. - (Eesti Kirjameeste Seltsi toimetised ; 3)

  14. The Role of ATRX in the Alternative Lengthening of Telomeres (ALT Phenotype

    Directory of Open Access Journals (Sweden)

    João P. Amorim

    2016-09-01

    Full Text Available Telomeres are responsible for protecting chromosome ends in order to prevent the loss of coding DNA. Their maintenance is required for achieving immortality by neoplastic cells and can occur by upregulation of the telomerase enzyme or through a homologous recombination-associated process, the alternative lengthening of telomeres (ALT. The precise mechanisms that govern the activation of ALT or telomerase in tumor cells are not fully understood, although cellular origin may favor one of the other mechanisms that have been found thus far in mutual exclusivity. Specific mutational events influence ALT activation and maintenance: a unifying frequent feature of tumors that acquire this phenotype are the recurrent mutations of the Alpha Thalassemia/Mental Retardation Syndrome X-Linked (ATRX or Death-Domain Associated Protein (DAXX genes. This review summarizes the established criteria about this phenotype: its prevalence, theoretical molecular mechanisms and relation with ATRX, DAXX and other proteins (directly or indirectly interacting and resulting in the ALT phenotype.

  15. The Advanced Limiter Test-I (ALT-I) variable-geometry pump limiter module

    International Nuclear Information System (INIS)

    Pontau, A.E.; Malinowski, M.E.; Ver Berkmoes, A.A.; Guthrie, S.E.; Watson, R.D.; Goebel, D.M.; Campbell, G.A.

    1984-01-01

    The ALT-I variable geometry module has been designed to address many of the issues not previously settled by earlier experiments. The goal is to study the basic processes involved in pump limiter operation as well as demonstrate its utility and effect on the plasma. The flexibility and extensive instrumentation of ALT-I will offer a unique opportunity to parameterize operation and facilitate the engineering design of future pump limiters. (orig.)

  16. The 'donations for decreased ALT (D4D)' prosocial behavior incentive scheme for NAFLD patients.

    Science.gov (United States)

    Sumida, Yoshio; Yoshikawa, Toshikazu; Tanaka, Saiyu; Taketani, Hiroyoshi; Kanemasa, Kazuyuki; Nishimura, Tekeshi; Yamaguchi, Kanji; Mitsuyoshi, Hironori; Yasui, Kohichiroh; Minami, Masahito; Naito, Yuji; Itoh, Yoshito

    2014-12-01

    Physicians often experience difficulties in motivating patients with non-alcoholic fatty liver disease (NAFLD) to undergo lifestyle changes. The aim of this study is to examine whether 'Donations for Decreased alanine aminotransferase (ALT)' (D4D) prosocial behavior incentive can serve as an effective intrinsic motivational factor in comparison with conventional dietary and exercise intervention alone for NAFLD patients. Twenty-five NAFLD patients with elevated ALT were randomly assigned to a control group that received conventional dietary and exercise intervention alone, or a donation group whereby, as an incentive, we would make a monetary donation to the United Nations World Food Programme (WFP) based on the decrease in their ALT levels achieved over 12 weeks, in addition to receiving control intervention. In a donation group, we would donate US$1 to the WFP for every 1 IU/l of decrease in their ALT levels. There were no differences of pre-treatment clinical characteristics between the two groups. Significant reductions of ALT levels were achieved only in a donation group, although post-treatment ALT levels were not different between the two groups. These patients raised a total of $316 for the WFP. Promoting patients' intrinsic motivation by incorporating 'D4D' prosocial behavior incentive into conventional dietary and exercise intervention may provide a means to improve NAFLD. © The Author 2013. Published by Oxford University Press on behalf of Faculty of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  17. Baczoni, Tamás, Tibor Balla et al. eds. 2014. A Nagy Háború, 1914-1918 - kézzelfogható hadtörténelem (The Great War, 1914-1918 - Tangible Military History]. Budapest: Zrínyi Kiadó, Honvédelmi Minisztérium Hadtörténeti Intézet és Múzeum munkatársai (Staff of the Institute and Museum of Military History Ministry of Defense. 68 pp. Two DVDs and fifty-six reproduced documentary inserts.

    Directory of Open Access Journals (Sweden)

    George Deák

    2017-09-01

    Full Text Available Baczoni, Tamás, Tibor Balla et al. eds. 2014. A Nagy Háború, 1914-1918 - kézzelfogható hadtörténelem (The Great War, 1914-1918 - Tangible Military History]. Budapest: Zrínyi Kiadó, Honvédelmi Minisztérium Hadtörténeti Intézet és Múzeum munkatársai (Staff of the Institute and Museum of Military History Ministry of Defense. 68 pp. Two DVDs and fifty-six reproduced documentary inserts.

  18. The helicase domain of Polθ counteracts RPA to promote alt-NHEJ.

    Science.gov (United States)

    Mateos-Gomez, Pedro A; Kent, Tatiana; Deng, Sarah K; McDevitt, Shane; Kashkina, Ekaterina; Hoang, Trung M; Pomerantz, Richard T; Sfeir, Agnel

    2017-12-01

    Mammalian polymerase theta (Polθ) is a multifunctional enzyme that promotes error-prone DNA repair by alternative nonhomologous end joining (alt-NHEJ). Here we present structure-function analyses that reveal that, in addition to the polymerase domain, Polθ-helicase activity plays a central role during double-strand break (DSB) repair. Our results show that the helicase domain promotes chromosomal translocations by alt-NHEJ in mouse embryonic stem cells and also suppresses CRISPR-Cas9- mediated gene targeting by homologous recombination (HR). In vitro assays demonstrate that Polθ-helicase activity facilitates the removal of RPA from resected DSBs to allow their annealing and subsequent joining by alt-NHEJ. Consistent with an antagonistic role for RPA during alt-NHEJ, inhibition of RPA1 enhances end joining and suppresses recombination. Taken together, our results reveal that the balance between HR and alt-NHEJ is controlled by opposing activities of Polθ and RPA, providing further insight into the regulation of repair-pathway choice in mammalian cells.

  19. General Time-Division AltBOC Modulation Technique for GNSS Signals

    Directory of Open Access Journals (Sweden)

    Z. Zhou

    2018-04-01

    Full Text Available In this paper, a general time-division alternate binary offset carrier (GTD-AltBOC modulation method is proposed, which is an extension of TD-AltBOC and time-multiplexed offset-carrier quadrature phase shift keying (TMOC-QPSK with high design flexibility. In this method, binary complex subcarriers and a time-division technique with flexible time slot assignment are used to achieve constant envelope modulation of the signal components with a variable power allocation ratio (PAR. The underlying principle of GTD-AltBOC and the constraints related to the PAR are investigated. For the generation of GTD-AltBOC signals, a lookup table (LUT-based scheme is presented; the minimum required clock rate is half or less of that for existing non-time-division methods. The receiver processing complexities are analyzed for three typical receiving modes, and the power spectral densities (PSDs, cross-correlation functions, multiplexing efficiencies and code-tracking performance are simulated; the results show that GTD-AltBOC enables a significant decrease in receiving complexity compared with existing methods while maintaining high performance in terms of multiplexing efficiency and code tracking.

  20. THE CHIMERIC ALT-VASTUS LATERALIS FREE FLAP IN RECONSTRUCTION OF ADVANCED BRONJ OF THE MAXILLA

    Directory of Open Access Journals (Sweden)

    Francesca Toia

    2015-04-01

    Full Text Available ntroduction Bisphosphonate-related osteonecrosis of the jaw (BRONJ is a dangerous complication of bisphosphonates, a class of pharmaceutical agents used in numerous bone disorders. No gold standard therapy exists, but recent literature suggests that, in advanced stages, the best results are achieved with aggressive debridement. In this paper, we report our experience of treatment of stage 3 BRONJ of the maxilla with extensive surgical debridement and reconstruction with a chimeric ALT-Vastus lateralis flap. Methods Five selected patients with stage 3 BRONJ underwent partial maxillectomy with disease-free margins followed by immediate reconstruction with a chimeric ALT-Vastus lateralis free flap. Results Only two patients experienced minor complications. All other patients healed uneventfully within two weeks and donor site morbidity was minimal. Conclusions Our data suggest that aggressive debridement and reconstruction with a chimeric ALT -Vastus lateralis flap is an effective option for the treatment of stage III BRONJ of the maxilla.

  1. Environmental Stress Induces Trinucleotide Repeat Mutagenesis in Human Cells by Alt-Nonhomologous End Joining Repair.

    Science.gov (United States)

    Chatterjee, Nimrat; Lin, Yunfu; Yotnda, Patricia; Wilson, John H

    2016-07-31

    Multiple pathways modulate the dynamic mutability of trinucleotide repeats (TNRs), which are implicated in neurodegenerative disease and evolution. Recently, we reported that environmental stresses induce TNR mutagenesis via stress responses and rereplication, with more than 50% of mutants carrying deletions or insertions-molecular signatures of DNA double-strand break repair. We now show that knockdown of alt-nonhomologous end joining (alt-NHEJ) components-XRCC1, LIG3, and PARP1-suppresses stress-induced TNR mutagenesis, in contrast to the components of homologous recombination and NHEJ, which have no effect. Thus, alt-NHEJ, which contributes to genetic mutability in cancer cells, also plays a novel role in environmental stress-induced TNR mutagenesis. Published by Elsevier Ltd.

  2. Langmuir probe measurements in the TEXTOR tokamak during ALT-I pump limiter experiments

    International Nuclear Information System (INIS)

    Goebel, D.M.; Campbell, G.A.; Conn, R.W.; Leung, W.K.; Dippel, K.H.; Finken, K.H.; Thomas, G.J.; Pontau, A.E.

    1986-04-01

    Langmuir probes have been used to characterize the edge plasma of the TEXTOR tokamak and measure the parameters of the plasma incident on the ALT-I pump limiter during ohmic and ICRH heating. Probes mounted directly on the ALT limiter, and a scanning probe located 90 0 toroidally from the limiter, provide data for the evaluation of pump limiter performance and its effect on the edge plasma. The edge plasma is characterized by density and flux e-folding lengths of about 1.8cm when ALT is the main limiter. These scrape-off lengths do not vary significantly as ALT is moved between the normal 42-46cm minor radii, but increase to over 2.2cm when ALT is inserted to 40cm. The flux to probes at a fixed position in the limiter shadow varies by less than 25% for core density changes of a factor of five. This suggests that the global particle confinement time tau/sub p/, scales as the core density. Estimates from the probes indicate that tau/sub p/ is on the order of the energy confinement time, tau/sub E/. The edge electron temperature, T/sub e/, typically decreases by a factor of two when the core density is raised from 1 to 4 x 10 13 cm -3 . The T/sub e/ profile is essentially flat in the limiter shadow, with values of 10-25 eV depending on the core plasma density and ICRH power. ICRH heating increases the electron temperature and flux in proportion to the coupled power. With ALT as the primary limiter and no direct shadowing, the ion side receives 2 to 3 times the flux of the electron side during both ohmic and ICRH heating. The edge plasma is not directly modified by pump limiter operation, but changes with the core plasma density as particle removal lowers the recycling of neutrals in the boundary

  3. Measurement and purification of Alanine aminotransferase (ALT enzyme activity in patients with celiac disease

    Directory of Open Access Journals (Sweden)

    Taghreed U. Mohammed

    2017-09-01

    Full Text Available Celiac disease (CD is the most common genetically - based disease in correlation with food intolerance. The aim of this study is to measure the activity of ALT enzyme and purify enzyme from sera women with celiac disease. Alanine aminotransferase (ALT activity has been assayed in (30 women serum samples with celiac disease, age range between (20-40 year and (30 serum of healthy women as control group, age range between (22-38 year. In the present study, the mean value of ALT activity was significantly higher in patients with celiac disease than healthy group (p<0.01. The ALT enzyme was partial purified from sera women with celiac disease by dialysis, gel filtration using Sephadex G- 50 and ion exchange chromatography using DEAE- cellulose A-50 . The results showed a single peak by using gel filtration and the activity reached 31-15 U/L .Two isoenzymes were obtained by using ion exchange chromatography and the purity degree of isoenzymse (I, II were (5.7 and (5.53 fold respectively

  4. Effect of Ramadan fasting on alanine transferase (ALT in nonalcoholic fatty liver disease (NAFLD

    Directory of Open Access Journals (Sweden)

    Hojjatolah Rahimi

    2017-09-01

    Full Text Available Background: The effects of Ramadan fasting on NAFLD are unknown and there are very limited studies have done in this area. Some nutritional and behavioral changes of fasting people in Ramadan can affect NAFLD. These include nutrition with high fat and calories, altering in weight and sleep and low physical activity. We decided to evaluate the effects of these changes on one of the important indicators of deterioration of NAFLD, ALT.Methods: Sixty patients with fatty liver disease performed two consecutive ALT exams before and after Ramadan month of whom finally 34 were fasting and 26 nonfasting. After collecting data they were divided in two groups of fasting and nonfasting and compared using SPSS software.Results: Mean ALT change from before to after Ramadan was higher and positive in fasting (+7.38±8.47 IU/L compared to nonfastng patients that was negative (-0.12±10.15 IU/L (P=0.002 and this change was mainly in patients who had fasted 21-30 days.Conclusion: Ramadan fasting may increase ALT. It is needed to perform more studies in patients with NAFLD during Ramadan fasting with larger sample size and in various conditions especially weight loss with patients’ education for observing dietary regimen.

  5. Influence of gender, BMI, and ethnicity on serum ALT levels of healthy students of a medical school

    International Nuclear Information System (INIS)

    Bilal, M.; Tariq, A.; Khan, S.; Quratulain, A.; Tariq, A.; Shahid, M.F.; Khan, M.W.; Naveed, A.K.

    2011-01-01

    Background: Alanine Aminotransferase (ALT) is an enzyme found in Liver and indicates injury to Hepatocytes. It is influenced by various factors. The objectives of this study were to identify the correlates of ALT activity among healthy medical students of Army Medical College, National University of Sciences and Technology, aged 18-22 years. This was to establish the mean ALT levels of the students and compare them with those in various parts of the world and observe various correlations that exist and factors that may influence ALT levels. Methods: This population included 143 volunteer students (93 men and 50 women) selected on the basis of negative answers to a detailed medical questionnaire including past medical history, drug and alcohol consumption, on the absence of clinical signs of liver disease, on the negativity of serological testing for Hepatitis B and C virus. Results: The mean ALT level of the entire population was 28.7 IU/L. A major sex-difference in ALT value was observed, the mean ALT value being higher in men than in women (32.1+- 21.7 vs. 22.6 +- 9.7 IU/L, p<0.004). According to WHO criteria for Asians, normal BMI was taken from 18.5-23.0 Kg/m/sup 2/. There was a positive significant correlation between serum ALT level and BMI (p<0.002). ALT level strongly correlates with body mass index and gender. There was no significant variation in ALT levels among Punjabis and Sindhis, Balochis, Pathans, and Kashmiris. Conclusion: We suggest the need of taking into account these parameters in a clinical interpretation of ALT level. (author)

  6. Patrika - alt

    Indian Academy of Sciences (India)

    brilliant printers

    the meeting from around the country a greater interaction with Fellows. There were sixteen 30-minutes ... development in plants; (e) experimental evolutionary biology; (f) discrete groups of ..... were provided by “deep ecology”, a doctrine of questionable intellectual .... pollination, dispersal, mutualisms etc. The advantage of.

  7. Mutational analysis of the activator of late transcription, Alt , in the lactococcal bacteriophage TP901-1

    DEFF Research Database (Denmark)

    Pedersen, Margit; Hammer, Karin

    2007-01-01

    An activator protein, Alt, synthesized during the early state of lytic infection is required for transcription of the late operon in the lactococcal phage TP901-1. In order to identify amino acid residues in the Alt protein required for activation of the TP901-1 late promoter, Plate, hydroxylamine...

  8. Association between ALT level and the rate of cardio/cerebrovascular events in HIV-positive individuals

    DEFF Research Database (Denmark)

    Sabin, Caroline A; Ryom, Lene; Kovari, Helen

    2013-01-01

    An inverse association between serum alanine aminotransferase (ALT) levels and the risk of myocardial infarction (MI) has been reported in the general population. We investigated associations between ALT levels and the risk of various cardiovascular and cerebrovascular outcomes in a large cohort ...

  9. Mre11 and Blm-Dependent Formation of ALT-Like Telomeres in Ku-Deficient Ustilago maydis.

    Directory of Open Access Journals (Sweden)

    Eun Young Yu

    2015-10-01

    Full Text Available A subset of human cancer cells uses a specialized, aberrant recombination pathway known as ALT to maintain telomeres, which in these cells are characterized by complex aberrations including length heterogeneity, high levels of unpaired C-strand, and accumulation of extra-chromosomal telomere repeats (ECTR. These phenotypes have not been recapitulated in any standard budding or fission yeast mutant. We found that eliminating Ku70 or Ku80 in the yeast-like fungus Ustilago maydis results initially in all the characteristic telomere aberrations of ALT cancer cells, including C-circles, a highly specific marker of ALT. Subsequently the ku mutants experience permanent G2 cell cycle arrest, accompanied by loss of telomere repeats from chromosome ends and even more drastic accumulation of very short ECTRs (vsECTRs. The deletion of atr1 or chk1 rescued the lethality of the ku mutant, and "trapped" the telomere aberrations in the early ALT-like stage. Telomere abnormalities are telomerase-independent, but dramatically suppressed by deletion of mre11 or blm, suggesting major roles for these factors in the induction of the ALT pathway. In contrast, removal of other DNA damage response and repair factors such as Rad51 has disparate effects on the ALT phenotypes, suggesting that these factors process ALT intermediates or products. Notably, the antagonism of Ku and Mre11 in the induction of ALT is reminiscent of their roles in DSB resection, in which Blm is also known to play a key role. We suggest that an aberrant resection reaction may constitute an early trigger for ALT telomeres, and that the outcomes of ALT are distinct from DSB because of the unique telomere nucleoprotein structure.

  10. Genel Anestezi Altında Çocukta Diş Tedavisi

    OpenAIRE

    Gülhan, A.; Sandallı, N.

    2013-01-01

    ÖZETBu makalede çocuklarda genel anestezi altında diş tedavisinin koşulları anlatıldı ve normal tedavi koşulları sağlanamadığı takdirde, genel anesteziye başvurmanın yararlarına ve sakıncalarına değinildi. Genel anestezi indikasyonları sıralanarak, bunlar arasında en sık rastladığımız «Güç çocuklarım" genci anesteziye başvurmadan Önce hangi yollara başvurularak normal tedavinin deneneceğinden bahsedildi.Bir hastane ortamında genel anestezi altında çalışmaya karar verildikten sonra, bir a...

  11. Biomaterial properties evaluation of poly(vinyl acetate- alt-maleic anhydride)/chitosan nanocapsules

    Science.gov (United States)

    Raţă, Delia Mihaela; Popa, Marcel; Chailan, Jean-François; Zamfir, Carmen Lăcrămioara; Peptu, Cătălina Anişoara

    2014-08-01

    Nanocapsules with diameter around 100 nm based on a natural polymer (chitosan) and a synthetic polymer poly(vinyl acetate- alt-maleic anhydride) [poly(MAVA)] by interfacial condensation method were prepared. The present study proposes a new type of biocompatible nanocapsules based on poly(vinyl acetate- alt-maleic anhydride-chitosan) (MCS) able to become a reliable support for inclusion and release of drugs. The spherical shape of the nanocapsules was evidenced by scanning electron microscopy. Nanocapsules presented a good Norfloxacin loading and release capacity. Haemocompatibility tests have demonstrated that the nanocapsules present a low toxicity and a good compatibility with sanguine medium. The biocompatibility properties of the nanocapsules after their intraperitoneal administration in rats were evidenced by histopathological examination of different organs (brain, liver, kidney, and lung). The results are encouraging and the nanocapsules can be used as controlled drug delivery systems.

  12. Preliminary design analysis of the ALT-II limiter for TEXTOR

    International Nuclear Information System (INIS)

    Koski, J.A.; Boyd, R.D.; Kempka, S.M.; Romig, A.D. Jr.; Smith, M.F.; Watson, R.D.; Whitley, J.B.; Conn, R.W.; Grotz, S.P.

    1984-01-01

    Installation of a large toroidal belt pump limiter, Advanced Limiter Test II (ALT-II), on the TEXTOR tokamak at Juelich, FRG is anticipated for early 1986. This paper discusses the preliminary mechanical design and materials considerations undertaken as part of the feasibility study phase for ALT-II. Since the actively cooled limiter blade is the component in direct contact with the plasma edge, and thus subject to the severe plasma environment, most preliminary design efforts have concentrated on analysis of the blade. The screening process which led to the recommended preliminary design consisting of a dispersion strenghthened copper or OFHC copper cover plate over an austenitic stainless steel base plate is discussed. A 1 to 3 mm thick low atomic number coating consisting of a graded plasma-sprayed Silicon Carbide-Aluminium composite is recommended subject to further experiment and evaluation. Thermal-hydraulic and stress analyses of the limiter blade are also discussed. (orig.)

  13. Antioxidant and Antifatigue Activities of Polygonatum Alte-lobatum Hayata Rhizomes in Rats

    Directory of Open Access Journals (Sweden)

    Chi-Ting Horng

    2014-11-01

    Full Text Available Polygonatum alte-lobatum Hayata, a rhizomatous perennial herb, belongs to the Liliaceae family and is endemic to Taiwan. We investigated the antioxidant and anti-fatigue activities of P. alte-lobatum in exercised rats. Levels of polyphenols, flavonoids and polysaccharides and 2,2-diphenyl-1-picrylhydrazyl (DPPH free-radical scavenging activity were measured in extracts of P. alte-lobatum (EPA. Sprague-Dawley rats were randomly divided into four groups for 8-week treatment with vehicle (control and low-, medium-, and high-dose EPA (LEPA, MEPA, HEPA; 0, 75, 150, and 375 mg/kg/day, respectively. Exercise performance was evaluated by exhaustive treadmill exercise time and by changes in body composition and biochemical variables at the end of the experiment. EPA contained polyphenols, flavonoids and polysaccharides, with polysaccharide content at least 26 times greater than that of polyphenols and flavonoids. Trend analysis revealed that EPA dose-dependently scavenged DPPH free radicals. EPA treatment dose-dependently increased endurance running time to exhaustion and superoxide dismutase activity and total antioxidant ability of blood. EPA dose-dependently decreased serum urea nitrogen and malondialdehyde levels after exercise. Hepatic glycogen content, an important energy source for exercise, was significantly increased with EPA treatment. EPA could be a potential agent with an anti-fatigue pharmacological function.

  14. Liver stiffness becomes stable in patients with chronic hepatitis C three months after ALT normalization due to antiviral therapy

    Directory of Open Access Journals (Sweden)

    CHEN Feikai

    2013-10-01

    Full Text Available ObjectiveTo investigate the time for liver stiffness measurement (LSM to become stable in chronic hepatitis C (CHC patients with elevated alanine aminotransferase (ALT levels after ALT normalization due to antiviral therapy. MethodsCHC patients who sought initial treatment at Peking University People′s Hospital were screened for elevated ALT levels from May 2011. Liver stiffness was determined by FibroScan. A total of 29 patients had been included in the study by September 2012, who were followed up regularly after antiviral treatment. ALT tests were repeated every four weeks and LSM every eight weeks until their medians did not change significantly. Comparisons of matched data at two adjacent time points were made with the non-parametric Wilcoxon test, while multiple comparisons of repeated measurements were performed using Bonferroni correction. Correlation between two variables was analyzed with the Spearman rank test. ResultsPatients were followed up until 24 weeks after antiviral treatment, and 24 patients were included in analysis. The median ALT levels were 64, 26, 21, 20, and 22 U/L at baseline and 4, 8, 12, and 24 weeks, respectively (P= 0.000, 0.006, 0.337, and 0.109 for comparisons between two adjacent values. ALT decreased significantly below 1 ULN at 4 weeks after antiviral therapy and stabilized at 8 weeks. The median LSM values were 8.7, 7.8, 6.8, and 6.7 kPa at baseline and 8, 16, and 24 weeks, respectively (P= 0.009, 0.001, and 0188 for comparisons between two adjacent values. LSM decreased significantly within 16 weeks after antiviral therapy and stabilized afterwards. LSM stabilized 12 weeks after ALT normalization. ConclusionLSM becomes stable in CHC patients with elevated ALT levels three months after ALT normalization due to antiviral therapy.

  15. Evidence for alternative lengthening of telomeres in liposarcomas in the absence of ALT-associated PML bodies.

    Science.gov (United States)

    Jeyapalan, Jennie N; Mendez-Bermudez, Aaron; Zaffaroni, Nadia; Dubrova, Yuri E; Royle, Nicola J

    2008-06-01

    Immortalized and cancer cells maintain their telomeres by activation of a telomere maintenance mechanism (TMM). In approximately 85% of cancers telomerase is activated (TA) but in some tumours, in particular sarcomas, an alternative lengthening of telomeres (ALT) pathway is used. Liposarcomas are the most common soft-tissue sarcoma in adults and they activate ALT or telomerase with equal frequency, however no TMM has been identified in approximately 50% of liposarcomas. In our study, we have shown that instability at the minisatellite MS32, usually associated with ALT activation, aids the identification of liposarcomas that have recombination-like activity at telomeres in absence of ALT associated PML-bodies (APBs). Furthermore, using single molecule telomere analysis, we have detected complex telomere mutations directly in ALT positive liposarcomas and interestingly in some liposarcomas with an unknown TMM but high MS32 instability. We have shown by sequence analysis that some of these complex telomere mutations must arise by an inter-molecular recombination-like process rather than by deletion caused by t-loop excision or by unequal telomere-sister-chromatid-exchange (T-SCE), which is known to be elevated in ALT cell lines. Preliminary evidence also suggests that inter-molecular recombination events may be processed differently in liposarcomas with APBs compared to those without. In conclusion, we have shown for the first time, that some telomerase negative liposarcomas without APBs have other features associated with ALT, indicating that the incidence of ALT in these tumours has previously been under-estimated. This has major implications for the use of cancer treatments targeted at TMMs. (c) 2008 Wiley-Liss, Inc.

  16. Correlation between Aminotransferase Ratio (AST/ALT and Other Biochemical Parameters in Chronic Liver Disease of Viral Origin

    Directory of Open Access Journals (Sweden)

    Shah Md Fazlul Karim

    2015-03-01

    Full Text Available Background: In recent years the ratio of aspartate aminotransferase (AST to alanine aminotransferase (ALT in patients of chronic liver disease (CLD of various origins has gained much attention. This variable is readily available, easy to interpret, and inexpensive and the clinical utility of the AST/ALT ratio in the diagnostic workup of patients with CLD is quite promising. Objective: The present study was designed to find out the link between aminotransferase (AST/ALT ratio with commonly measured biochemical parameters of liver function tests in CLD of viral origin. Materials and method: This cross sectional study was carried out in the department of Biochemistry, Sir Salimullah Medical College, Dhaka, Bangladesh. Forty four biopsy proven diagnosed subjects of chronic viral hepatitis without cirrhosis of both sex were selected purposively. With aseptic precaution 5 mL venous blood was collected from each subject and common liver function tests (serum AST, ALT, AST/ALT ratio, alkaline phosphatase, total bilirubin, serum total protein, serum albumin, serum globulin, serum albumin/globulin ratio, prothrombin time and viral serology (HBsAg, Anti HDV antibody, Anti HCV antibody were performed. Data were analyzed by SPSS version 19 for Windows. Pearson’s correlation test was done to determine association between AST/ALT with other biochemical parameters. Results: Mean(±SD age of the study subjects was 32.55±10.55 years (range 20-50 years with 48 (77.7% male and 14 (22.6% female subjects. Pearson’s correlation test was done between AST to ALT ratio with other biochemical parameters and prothrombin time showed significant positive correlation (p <0.01. Conclusion: In our study we found significant positive correlation between AST/ALT with prothrombin time in CLD subjects without cirrhosis.

  17. Serum ALT levels as a surrogate marker for serum HBV DNA levels in HBeAg-negative pregnant women.

    Science.gov (United States)

    Sangfelt, Per; Von Sydow, Madeleine; Uhnoo, Ingrid; Weiland, Ola; Lindh, Gudrun; Fischler, Björn; Lindgren, Susanne; Reichard, Olle

    2004-01-01

    In Stockholm, Sweden, the majority of pregnant women positive for hepatitis B surface antigen (HBsAg) are hepatitis Be antigen (HBeAg) negative. Newborns to HBeAg positive mothers receive vaccination and hepatitis B immunoglobulin (HBIg). Newborns to HBeAg negative mothers receive vaccine and HBIg only if the mothers have elevated ALT levels. The aim of this study was to retrospectively evaluate ALT levels as a surrogate marker for HBV DNA levels in HBeAg negative carrier mothers. Altogether 8947 pregnant women were screened for HBV markers from 1999 to 2001 at the Virology Department, Karolinska Hospital. Among mothers screened 192 tested positive for HBsAg (2.2%). 13 of these samples could not be retrieved. Of the remaining 179 sera, 8 (4%) tested positive for HBeAg and 171 (95.5%) were HBeAg negative. Among the HBeAg negative mothers, 9 had HBV DNA levels > 10(5) copies/ml, and of these 7 had normal ALT levels indicating low sensitivity of an elevated ALT level as a surrogate marker for high HBV DNA level. Furthermore, no correlation was found between ALT and HBV DNA levels. Hence, it is concluded that the use of ALT as a surrogate marker for high viral replication in HBeAg negative mothers could be questioned.

  18. An assessment of racial differences in the upper limits of normal ALT levels in children and the effect of obesity on elevated values.

    Science.gov (United States)

    Kliethermes, S; Ma, M; Purtell, C; Balasubramanian, N; Gonzalez, B; Layden, T J; Cotler, S J

    2017-10-01

    Childhood obesity is a risk factor for non-alcoholic fatty liver disease and poses important public health issues for children. Racial differences in alanine aminotransferase (ALT) levels among children have not been described. This study aimed to identify racial differences in upper limit normal (ULN) ALT levels and evaluate the effect of obesity on elevated levels in children without other metabolic risk factors. National Health and Nutrition Examination Surveys and clinical data from the Loyola University Health System were used to determine ULN ALT by race and gender. Quantile regression was used to evaluate the impact of obesity on elevated ALT and to identify potential risk factors for ALT above the ULN. Upper limit normal (ULN) ALT was approximately 28.0 and 21.0-24.0 U/L for boys and girls, respectively. No significant difference in ULN ALT across race was observed. Obesity was significantly associated with elevated ALT; obese children with elevated ALT had values 10 U/L higher than normal-weight children. Racial differences in ALT levels among adults are not evident in children. Obesity, in the absence of metabolic risk factors and other causes of liver disease, is associated with elevated ALT, providing evidence against the concept of healthy obesity in children. © 2016 World Obesity Federation.

  19. "Almha La Vengadora": Protagonista del indigenismo de neovanguardia alteño

    Directory of Open Access Journals (Sweden)

    Maria Irina Soto-Mejia

    2016-03-01

    Este artículo discute la obra de Crispín Portugal (1976-2007, un escritor alteño, en el contexto de la lucha contra la pobreza y el racismo que enfrentan a las ciudades de El Alto y La Paz, y del movimiento en contra del mercado  que comenzó en Argentina produciendo libros con tapas de cartón compradas a los cartoneros. Portugal y otros escritores indígenas iniciaron un proyecto editorial llamado Yerba Mala Cartonera, que cuenta con su propio blog, para diseminar la literatura boliviana que no cuenta con otros medios de difusión. A través de la revisión de un cuento de Portugal (Almha La Vengadora que describe a una chola luchadora de El Alto cuyo nombre en el cuadrilátero es “la vengadora”, este trabajo plantea la configuración de un indigenismo alteño de neovanguardia equiparable al vanguardismo de Gamaliel Churata.  Con este propósito, presta especial atención a El Alto –la ciudad indígena más grande de Latinoamérica- situándolo como escenario clave para el desarrollo de una neovanguardia que se alimenta del neoliberalismo fallido para configurar una propuesta de modernidad que recupera el pasado indígena aymara para inventar otras formas de futuro.

  20. Incremental Predictive Value of Serum AST-to-ALT Ratio for Incident Metabolic Syndrome: The ARIRANG Study

    Science.gov (United States)

    Ahn, Song Vogue; Baik, Soon Koo; Cho, Youn zoo; Koh, Sang Baek; Huh, Ji Hye; Chang, Yoosoo; Sung, Ki-Chul; Kim, Jang Young

    2016-01-01

    Aims The ratio of aspartate aminotransferase (AST) to alanine aminotransferase (ALT) is of great interest as a possible novel marker of metabolic syndrome. However, longitudinal studies emphasizing the incremental predictive value of the AST-to-ALT ratio in diagnosing individuals at higher risk of developing metabolic syndrome are very scarce. Therefore, our study aimed to evaluate the AST-to-ALT ratio as an incremental predictor of new onset metabolic syndrome in a population-based cohort study. Material and Methods The population-based cohort study included 2276 adults (903 men and 1373 women) aged 40–70 years, who participated from 2005–2008 (baseline) without metabolic syndrome and were followed up from 2008–2011. Metabolic syndrome was defined according to the harmonized definition of metabolic syndrome. Serum concentrations of AST and ALT were determined by enzymatic methods. Results During an average follow-up period of 2.6-years, 395 individuals (17.4%) developed metabolic syndrome. In a multivariable adjusted model, the odds ratio (95% confidence interval) for new onset of metabolic syndrome, comparing the fourth quartile to the first quartile of the AST-to-ALT ratio, was 0.598 (0.422–0.853). The AST-to-ALT ratio also improved the area under the receiver operating characteristic curve (AUC) for predicting new cases of metabolic syndrome (0.715 vs. 0.732, P = 0.004). The net reclassification improvement of prediction models including the AST-to-ALT ratio was 0.23 (95% CI: 0.124–0.337, Pmetabolic syndrome and had incremental predictive value for incident metabolic syndrome. PMID:27560931

  1. The major Alternaria alternata allergen, Alt a 1: A reliable and specific marker of fungal contamination in citrus fruits.

    Science.gov (United States)

    Gabriel, M F; Uriel, N; Teifoori, F; Postigo, I; Suñén, E; Martínez, J

    2017-09-18

    The ubiquitously present spores of Alternaria alternata can spoil a wide variety of foodstuffs, including a variety of fruits belonging to the Citrus genus. The major allergenic protein of A. alternata, Alt a 1, is a species-specific molecular marker that has been strongly associated with allergenicity and phytopathogenicity of this fungal species. This study aimed to evaluate the potential of the detection of Alt a 1 as a reliable indicator of A. alternata contamination in citrus fruits. To accomplish this aim, sixty oranges were artificially infected with a spore suspension of A. alternata. Internal fruit material was collected at different incubation times (one, two and three weeks after the fungal inoculation) and used for both total RNA extraction and protein extraction. Alt a 1 detection was then performed by polymerase chain reaction (PCR) amplification using Alt a 1 specific primers and by enzyme-linked immunosorbent assay (ELISA). The experimental model presented in this work was effective to simulate the typical Alternaria black rot phenotype and its progression. Although both PCR and ELISA techniques have been successfully carried out for detecting Alt a 1 allergen in A. alternata infected oranges, the PCR method was found to be more sensitive than ELISA. Nevertheless, ELISA results were highly valuable to demonstrate that considerable amounts of Alt a 1 are produced during A. alternata fruit infection process, corroborating the recently proposed hypothesis that this protein plays a role in the pathogenicity and virulence of Alternaria species. Such evidence suggests that the detection of Alt a 1 by PCR-based assay may be used as a specific indicator of the presence of pathogenic and allergenic fungal species, A. alternata, in fruits. This knowledge can be employed to control the fungal infection and mitigate agricultural losses as well as human exposure to A. alternata allergens and toxins. Copyright © 2017 Elsevier B.V. All rights reserved.

  2. Ephedra alte (joint pine): an invasive, problematic weedy species in forestry and fruit tree orchards in Jordan.

    Science.gov (United States)

    Qasem, Jamal R

    2012-01-01

    A field survey was carried out to record plant species climbed by Ephedra alte in certain parts of Jordan during 2008-2010. Forty species of shrubs, ornamental, fruit, and forest trees belonging to 24 plant families suffered from the climbing habit of E. alte. Growth of host plants was adversely affected by E. alte growth that extended over their vegetation. In addition to its possible competition for water and nutrients, the extensive growth it forms over host species prevents photosynthesis, smothers growth and makes plants die underneath the extensive cover. However, E. alte did not climb all plant species, indicating a host preference range. Damaged fruit trees included Amygdalus communis, Citrus aurantifolia, Ficus carica, Olea europaea, Opuntia ficus-indica, and Punica granatum. Forestry species that were adversely affected included Acacia cyanophylla, Ceratonia siliqua, Crataegus azarolus, Cupressus sempervirens, Pinus halepensis, Pistacia atlantica, Pistacia palaestina, Quercus coccifera, Quercus infectoria, Retama raetam, Rhamnus palaestina, Rhus tripartita, and Zizyphus spina-christi. Woody ornamentals attacked were Ailanthus altissima, Hedera helix, Jasminum fruticans, Jasminum grandiflorum, Nerium oleander, and Pyracantha coccinea. Results indicated that E. alte is a strong competitive for light and can completely smother plants supporting its growth. A. communis, F. carica, R. palaestina, and C. azarolus were most frequently attacked.

  3. Ephedra alte (Joint Pine: An Invasive, Problematic Weedy Species in Forestry and Fruit Tree Orchards in Jordan

    Directory of Open Access Journals (Sweden)

    Jamal R. Qasem

    2012-01-01

    Full Text Available A field survey was carried out to record plant species climbed by Ephedra alte in certain parts of Jordan during 2008–2010. Forty species of shrubs, ornamental, fruit, and forest trees belonging to 24 plant families suffered from the climbing habit of E. alte. Growth of host plants was adversely affected by E. alte growth that extended over their vegetation. In addition to its possible competition for water and nutrients, the extensive growth it forms over host species prevents photosynthesis, smothers growth and makes plants die underneath the extensive cover. However, E. alte did not climb all plant species, indicating a host preference range. Damaged fruit trees included Amygdalus communis, Citrus aurantifolia, Ficus carica, Olea europaea, Opuntia ficus-indica, and Punica granatum. Forestry species that were adversely affected included Acacia cyanophylla, Ceratonia siliqua, Crataegus azarolus, Cupressus sempervirens, Pinus halepensis, Pistacia atlantica, Pistacia palaestina, Quercus coccifera, Quercus infectoria, Retama raetam, Rhamnus palaestina, Rhus tripartita, and Zizyphus spina-christi. Woody ornamentals attacked were Ailanthus altissima, Hedera helix, Jasminum fruticans, Jasminum grandiflorum, Nerium oleander, and Pyracantha coccinea. Results indicated that E. alte is a strong competitive for light and can completely smother plants supporting its growth. A. communis, F. carica, R. palaestina, and C. azarolus were most frequently attacked.

  4. Ephedra alte (Joint Pine): An Invasive, Problematic Weedy Species in Forestry and Fruit Tree Orchards in Jordan

    Science.gov (United States)

    Qasem, Jamal R.

    2012-01-01

    A field survey was carried out to record plant species climbed by Ephedra alte in certain parts of Jordan during 2008–2010. Forty species of shrubs, ornamental, fruit, and forest trees belonging to 24 plant families suffered from the climbing habit of E. alte. Growth of host plants was adversely affected by E. alte growth that extended over their vegetation. In addition to its possible competition for water and nutrients, the extensive growth it forms over host species prevents photosynthesis, smothers growth and makes plants die underneath the extensive cover. However, E. alte did not climb all plant species, indicating a host preference range. Damaged fruit trees included Amygdalus communis, Citrus aurantifolia, Ficus carica, Olea europaea, Opuntia ficus-indica, and Punica granatum. Forestry species that were adversely affected included Acacia cyanophylla, Ceratonia siliqua, Crataegus azarolus, Cupressus sempervirens, Pinus halepensis, Pistacia atlantica, Pistacia palaestina, Quercus coccifera, Quercus infectoria, Retama raetam, Rhamnus palaestina, Rhus tripartita, and Zizyphus spina-christi. Woody ornamentals attacked were Ailanthus altissima, Hedera helix, Jasminum fruticans, Jasminum grandiflorum, Nerium oleander, and Pyracantha coccinea. Results indicated that E. alte is a strong competitive for light and can completely smother plants supporting its growth. A. communis, F. carica, R. palaestina, and C. azarolus were most frequently attacked. PMID:22645486

  5. Alt a 1 allergen homologs from Alternaria and related taxa: analysis of phylogenetic content and secondary structure.

    Science.gov (United States)

    Hong, Soon Gyu; Cramer, Robert A; Lawrence, Christopher B; Pryor, Barry M

    2005-02-01

    A gene for the Alternaria major allergen, Alt a 1, was amplified from 52 species of Alternaria and related genera, and sequence information was used for phylogenetic study. Alt a 1 gene sequences evolved 3.8 times faster and contained 3.5 times more parsimony-informative sites than glyceraldehyde-3-phosphate dehydrogenase (gpd) sequences. Analyses of Alt a 1 gene and gpd exon sequences strongly supported grouping of Alternaria spp. and related taxa into several species-groups described in previous studies, especially the infectoria, alternata, porri, brassicicola, and radicina species-groups and the Embellisia group. The sonchi species-group was newly suggested in this study. Monophyly of the Nimbya group was moderately supported, and monophyly of the Ulocladium group was weakly supported. Relationships among species-groups and among closely related species of the same species-group were not fully resolved. However, higher resolution could be obtained using Alt a 1 sequences or a combined dataset than using gpd sequences alone. Despite high levels of variation in amino acid sequences, results of in silico prediction of protein secondary structure for Alt a 1 demonstrated a high degree of structural similarity for most of the species suggesting a conservation of function.

  6. [Impact analysis of shuxuetong injection on abnormal changes of ALT based on generalized boosted models propensity score weighting].

    Science.gov (United States)

    Yang, Wei; Yi, Dan-Hui; Xie, Yan-Ming; Yang, Wei; Dai, Yi; Zhi, Ying-Jie; Zhuang, Yan; Yang, Hu

    2013-09-01

    To estimate treatment effects of Shuxuetong injection on abnormal changes on ALT index, that is, to explore whether the Shuxuetong injection harms liver function in clinical settings and to provide clinical guidance for its safe application. Clinical information of traditional Chinese medicine (TCM) injections is gathered from hospital information system (HIS) of eighteen general hospitals. This is a retrospective cohort study, using abnormal changes in ALT index as an outcome. A large number of confounding biases are taken into account through the generalized boosted models (GBM) and multiple logistic regression model (MLRM) to estimate the treatment effects of Shuxuetong injections on abnormal changes in ALT index and to explore possible influencing factors. The advantages and process of application of GBM has been demonstrated with examples which eliminate the biases from most confounding variables between groups. This serves to modify the estimation of treatment effects of Shuxuetong injection on ALT index making the results more reliable. Based on large scale clinical observational data from HIS database, significant effects of Shuxuetong injection on abnormal changes in ALT have not been found.

  7. The medical laboratory issues about recommendation on uniform cutoff values of “normal” ALT in the ACG guidelines

    Directory of Open Access Journals (Sweden)

    YU Qian

    2018-01-01

    Full Text Available In the recent American clinical guidelines dealing with laboratory tests for evaluation of liver disease, the American College of Gastroenterology (ACG recommends ALT upper reference limits of 33 U/L for males and 25 U/L for females respectively, and that individuals with ALT above these “normal” cutoffs should be further investigated. Considering the differences between laboratory assays measuring ALT in our country, the standardization of methods and the consistency of results can not be completely ensured. The uniform “normal” range of ALT recommended by the ACG guidelines is largely based on findings from foreign studies and may not be suitable to Chinese population. On the other hand, reference upper/lower limits should not simply be equated with clinical decision thresholds. However, due to improper application of the related concepts of the above medical laboratory issues, simply recommending the uniform reference range of the ALT may lead to overdiagnosis and unnecessary follow-up examinations.

  8. A Human Long Non-Coding RNA ALT1 Controls the Cell Cycle of Vascular Endothelial Cells Via ACE2 and Cyclin D1 Pathway

    Directory of Open Access Journals (Sweden)

    Wen Li

    2017-10-01

    Full Text Available Background/Aims: ALT1 is a novel long non-coding RNA derived from the alternatively spliced transcript of the deleted in lymphocytic leukemia 2 (DLEU2. To date, ALT1 biological roles in human vascular endothelial cells have not been reported. Methods: ALT1 was knocked down by siRNAs. Cell proliferation was analyzed by cck-8. The existence and sequence of human ALT1 were identified by 3’ rapid amplification of cDNA ends. The interaction between lncRNA and proteins was analyzed by RNA-Protein pull down assay, RNA immunoprecipitation, and mass spectrometry analysis. Results: ALT1 was expressed in human umbilical vein endothelial cells (HUVECs. The expression of ALT1 was significantly downregulated in contact-inhibited HUVECs and in hypoxia-induced, growth-arrested HUVECs. Knocking down of ALT1 inhibited the proliferation of HUVECs by G0/G1 cell cycle arrest. We observed that angiotensin converting enzyme Ⅱ(ACE2 was a direct target gene of ALT1. Knocking-down of ALT1 or its target gene ACE2 could efficiently decrease the expression of cyclin D1 via the enhanced ubiquitination and degradation, in which HIF-1α and protein von Hippel-Lindau (pVHL might be involved. Conclusion: The results suggested the human long non-coding RNA ALT1 is a novel regulator for cell cycle of HUVECs via ACE2 and cyclin D1 pathway.

  9. Twist-3 effect from the longitudinally polarized proton for ALT in hadron production from pp collisions

    Directory of Open Access Journals (Sweden)

    Yuji Koike

    2016-08-01

    Full Text Available We compute the contribution from the longitudinally polarized proton to the twist-3 double-spin asymmetry ALT in inclusive (light hadron production from proton–proton collisions, i.e., p↑p→→hX. We show that using the relevant QCD equation-of-motion relation and Lorentz invariance relation allows one to eliminate the twist-3 quark-gluon correlator (associated with the longitudinally polarized proton in favor of one-variable twist-3 quark distributions and the (twist-2 transversity parton density. Including this result with the twist-3 pieces associated with the transversely polarized proton and unpolarized final-state hadron (which have already been calculated in the literature, we now have the complete leading-order cross section for this process.

  10. Incontri di Fisica delle Alte Energie Italian Meeting on High Energy Physics Napoli

    CERN Document Server

    Carlino, Gianpaolo; Merola, Leonardo; Paolucci, Pierluigi; Ricciardi, Giulia; IFAE 2007

    2008-01-01

    This book collects the Proceedings of the Workshop "Incontri di Fisica delle Alte Energie (IFAE) 2007, Napoli, 11-13 April 2007". This is the sixth edition of a series of meetings on fundamental research in particle physics and was attended by about 160 researchers. Presentations, both theoretical and experimental, addressed the status of Physics of the Standard Model and beyond, Flavour phyisc, Neutrino and Astroparticle physics, new technology in high energy physics. Special emphasis was given to the expectations of the forthcoming Large Hadron Collider, due in operation at the end of 2007. The venue of plenary sessions interleaved with parallel ones allowed for a rich exchange of ideas, presented in these Proceedings, that form a coherent picture of the findings and of the open questions in this extremely challenging cultural field. The venue of plenary sessions interleaved with parallel ones allowed for a rich exchange of ideas, presented in these Proceedings, that form a coherent picture of the findings ...

  11. Comparing the characteristics of highly cited titles and highly alted titles

    Energy Technology Data Exchange (ETDEWEB)

    Didegah, F.; Bowman, T.D.; Bowman, S.; Hartley, J.

    2016-07-01

    This study examines differences in the types of titles for articles that show high altmetric activity (highly alted articles) versus highly cited articles. This work expands on previous research on document titles in combination with a grounded theory approach to develop a codebook in which articles were manually coded based on 11 characteristics. The results show that there are differences and similarities in titles across many of the examined characteristics; highly cited titles and highly mentioned titles on Wikipedia have some similar characteristics such as they have the the highest percentage of substantive words; in addition, there are no or very few titles referencing outside or with humor/lightness on both platforms. Twitter and Facebook also showed some similarities having the highest percentage of humorous/light titles and lowest percentage of substantive words in their titles. (Author)

  12. 2017-04-28_W88 ALT 370 Program Overview(OUO).

    Energy Technology Data Exchange (ETDEWEB)

    Daniels, Vonceil

    2017-04-01

    All major program milestones have been met and the program is executing within budget. The ALT 370 program achieved Phase 6.4 authorization in February of this year. Five component Final Design Reviews (FDRs) have been completed, indicating progress in finalizing the design and development phase of the program. A series of ground-based qualification activities have demonstrated that designs are meeting functional requirements. The first fully functional flight test, FCET-53, demonstrated end-to-end performance in normal flight environments in February. Similarly, groundbased nuclear safety and hostile environments testing indicates that the design meets requirements in these stringent environments. The first in a series of hostile blast tests was successfully conducted in April.

  13. Diorganosilacetylene-alt-diorganosilvinylene polymers and a process densifying porous silicon-carbide bodies

    Science.gov (United States)

    Barton, Thomas J.; Ijadi-Maghsoodi, Sina; Pang, Yi

    1994-05-17

    The present invention provides linear organosilicon polymers including acetylene and vinylene moieties, and a process for their preparation. These diorganosilacetylene-alt-diorganosilvinylene linear polymers can be represented by the formula: --[--(R.sup.1)(R.sup.2)Si--C.tbd.C--(R.sup.3)(R.sup.4)Si--CH=CH--].sub.n-- , wherein n.gtoreq.2; and each R.sup.1, R.sup.2, R.sup.3, and R.sup.4 is independently selected from the group consisting of hydrogen, halogen, alkyl, alkenyl, aryl, and aralkyl radicals. The polymers are soluble in organic solvents, air stable, and can be pulled into fibers or cast into films. They can be thermally converted into silicon carbide ceramic materials.

  14. Naised käsu korras firmade juhatusse! Jah või ei? / Kairi Alt, Aveli Kippari, Karl Koort... [jt.

    Index Scriptorium Estoniae

    2011-01-01

    Küsimusele vastavad Columbus IT Partner Eesti AS personalijuht Kairi Alt, Stele ja Riveli omanik Aveli Kippari, AS Panaviatic'i turundusjuht Karl Koort, OÜ Tarkvara Tehnoloogia Arenduskeskuse tegevjuht Indrek Vainu, AS PricewaterhouseCoopers auditiosakonna direktor Eva Jansen, Kalev Chocolate Factory tootmisjuht Hardo Reinike

  15. Kas erivajadustega lapsed saavad õigel ajal abi? / Ene Mägi, Urve Raudsepp-Alt, Ale Sprenk, Peeter Aas

    Index Scriptorium Estoniae

    2009-01-01

    Küsimusele vastavad: Tallinna Ülikooli Kasvatusteaduste Instituudi eri- ja sotsiaalpedagoogika osakonna juhataja Ene Mägi, Tallinna Haridusameti üldhariduse osakonna peaspetsialist Urve Raudsepp-Alt, Krabi põhikooli direktor Ale Sprenk, Põlva Maavalitsuse haridus-, kultuuri- ja sotsiaalosakonna juhataja Peeter Aas

  16. The Transition between Telomerase and ALT Mechanisms in Hodgkin Lymphoma and Its Predictive Value in Clinical Outcomes

    Directory of Open Access Journals (Sweden)

    Radhia M’kacher

    2018-05-01

    Full Text Available Background: We analyzed telomere maintenance mechanisms (TMMs in lymph node samples from HL patients treated with standard therapy. The TMMs correlated with clinical outcomes of patients. Materials and Methods: Lymph node biopsies obtained from 38 HL patients and 24 patients with lymphadenitis were included in this study. Seven HL cell lines were used as in vitro models. Telomerase activity (TA was assessed by TRAP assay and verified through hTERT immunofluorescence expression; alternative telomere lengthening (ALT was also assessed, along with EBV status. Results: Both TA and ALT mechanisms were present in HL lymph nodes. Our findings were reproduced in HL cell lines. The highest levels of TA were expressed in CD30−/CD15− cells. Small cells were identified with ALT and TA. Hodgkin and Reed Sternberg cells contained high levels of PML bodies, but had very low hTERT expression. There was a significant correlation between overall survival (p < 10−3, event-free survival (p < 10−4, and freedom from progression (p < 10−3 and the presence of an ALT profile in lymph nodes of EBV+ patients. Conclusion: The presence of both types of TMMs in HL lymph nodes and in HL cell lines has not previously been reported. TMMs correlate with the treatment outcome of EBV+ HL patients.

  17. Morphological control of calcium oxalate particles in the presence of poly-(styrene-alt-maleic acid)

    International Nuclear Information System (INIS)

    Yu Jiaguo; Tang Hua; Cheng Bei; Zhao Xiujian

    2004-01-01

    Calcium oxalate (CaOx) particles exhibiting different shapes and phase structures were fabricated by a simple precipitation reaction of sodium oxalate with calcium chloride in the absence and presence of poly-(styrene-alt-maleic acid) (PSMA) as a crystal modifier at room temperature. The as-obtained products were characterized with scanning electron microscopy (SEM) and X-ray diffraction (XRD). The effects of reaction conditions including pH, [Ca 2+ ]/[C 2 O 4 2- ] ratio and concentration of PSMA and CaC 2 O 4 on the crystal forms and morphologies of the as-obtained calcium oxalate were investigated. The results show that various crystal morphologies of calcium oxalate, such as parallelograms, plates, spheres, bipyramids etc. can be obtained depending on the experimental conditions. Higher polymer concentration favors formation of the metastable calcium oxalate dihydrate (COD) crystals. Lower pH is beneficial to the formation of plate-like CaOx crystals. Especially, the monodispersed parallelogram-like CaOx crystals can be produced by PSMA as an additive at pH 2. PSMA may act as a good inhibitor for urolithiasis since it induces the formation of COD and reduces the particle size of CaOx. This research may provide new insight into the morphological control of CaOx particles and the prevention of urolithiasis

  18. The LTDP ALTS Project: Contributing to the Continued Understanding and Exploitation of the ATSR Time Series

    Science.gov (United States)

    Clarke, Hannah; Done, Fay; Casadio, Stefano; Mackin, Stephen; Dinelli, Bianca Maria; Castelli, Elisa

    2016-08-01

    The long time-series of observations made by the Along Track Scanning Radiometers (ATSR) missions represents a valuable resource for a wide range of research and EO applications.With the advent of ESA's Long-TermData Preservation (LTDP) programme, thought has turned to the preservation and improved understanding of such long time-series, to support their continued exploitation in both existing and new areas of research, bringing the possibility of improving the existing data set and to inform and contribute towards future missions. For this reason, the 'Long Term Stability of the ATSR Instrument Series: SWIR Calibration, Cloud Masking and SAA' project, commonly known as the ATSR Long Term Stability (or ALTS) project, is designed to explore the key characteristics of the data set and new and innovative ways of enhancing and exploiting it.Work has focussed on: A new approach to the assessment of Short Wave Infra-Red (SWIR) channel calibration.; Developmentof a new method for Total Column Water Vapour (TCWV) retrieval.; Study of the South Atlantic Anomaly (SAA).; Radiative Transfer (RT) modelling for ATSR.; Providing AATSR observations with their location in the original instrument grid.; Strategies for the retrieval and archiving of historical ATSR documentation.; Study of TCWV retrieval over land; Development of new methods for cloud masking This paper provides an overview of these activities and illustrates the importance of preserving and understanding 'old' data for continued use in the future.

  19. Plasma influence on throat conductance of the TEXTOR pump limiter ALT-I

    International Nuclear Information System (INIS)

    Hardtke, A.; Finken, K.H.; Reiter, D.; Dippel, K.H.; Goebel, D.M.; McGrath, R.T.; Sagara, A.

    1989-01-01

    On the TEXTOR pump limiter ALT-I conductance measurements for the backstreaming of gas from the pump limiter vessel through the pump limiter entrance have been performed. In these experiments neutral gas has been injected into the pump limiter plenum during a short pulse. The influence of the instreaming plasma results in a reduction of the conductance of the outstreaming gas. For helium the conductance is reduced to about 40% of the molecular conductance when a plasma flux of 0.8 A/cm 2 (T e =T i =11 eV) is streaming into the pump limiter throat. The reduction of the conductance for backstreaming hydrogen and deuterium under the same plasma conditions is smaller; about 70% of the molecular conductance is obtained. This reduction can be explained by an increased recycling of ions which have been produced in the throat back to the neutralizer plate. The experimental results can be reproduced by Monte Carlo neutral transport code calculations if the recycling coefficient is about 0.85 for hydrogen and deuterium and about 0.95 for helium ions. Processes causing these high recycling coefficients are discussed and their influence is estimated. (orig.)

  20. Prevalence of epilepsy and seizure disorders as causes of apparent life- threatening event (ALTE) in children admitted to a tertiary hospital.

    Science.gov (United States)

    Anjos, Alessandra Marques dos; Nunes, Magda Lahorgue

    2009-09-01

    To determine the prevalence and describe clinical characteristics of seizure disorders and epilepsy as causes of apparent life- threatening event (ALTE) in children admitted at the emergency and followed in a tertiary hospital. Cross-sectional study with prospective data collection using specific guidelines to determine the etiology of ALTE. During the study, 30 (4.2%) children admitted to the hospital had a diagnosis of ALTE. There was a predominance of males (73%) and term infants (70%). Neonatal neurological disorders and neuropsychomotor development delay were found respectively in 13.4% and 10% of the cases. Etiological investigation revealed that 50% of the cases were idiopathic, and 13.4% were caused by epilepsy or seizure disorders. Although all patients had recurrent ALTE events, epilepsy had not been previously suspected. Epilepsy should be included in the differential diagnosis of ALTE, particularly when events are recurrent.

  1. Simple synthesis of P(Cbz-alt-TBT) and PCDTBT by combining direct arylation with suzuki polycondensation of heteroaryl chlorides.

    Science.gov (United States)

    Lombeck, Florian; Matsidik, Rukiya; Komber, Hartmut; Sommer, Michael

    2015-01-01

    Direct arylation (DA) of 2-chlorothiophene and 2-chloro-3-hexylthiophene with 4,7-dibromo-2,1,3-benzothiadiazole is used to synthesize 4,7-bis(5-chloro-2-thienyl)-2,1,3-benzothiadiazole (TBTCl2) and 4,7-bis(5-chloro-4-hexyl-2-thienyl)-2,1,3-benzothiadiazole (DH-TBTCl2) in one step. Suitable conditions of the Suzuki polycondensations (SPC) of TBTCl2 and DH-TBTCl2 with the carbazole comonomer CbzPBE2 are established, furnishing PCDTBT and P(Cbz-alt-TBT) with high molecular weight and yield. Compared with control samples made from the corresponding dibromides, high-temperature NMR and UV-vis spectroscopy indicate similar properties for PCDTBT but an increased content of Cbz-Cbz homocouplings for P(Cbz-alt-TBT). © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  2. Clinico-biochemical factors to early predict biliary etiology of acute pancreatitis: age, female gender, and ALT.

    Science.gov (United States)

    Zarnescu, N O; Costea, R; Zarnescu Vasiliu, E C; Neagu, S

    2015-01-01

    Background/ Aims: Despite the existence of an easy tool to diagnose biliary tract disease as an etiology for acute pancreatitis (AP), the sensitivity of abdominal ultrasound is around 80%, which can be even lower in certain conditions. We have retrospectively reviewed data of 146 patients admitted for acute pancreatitis between 1999 and 2013. Bivariate analysis for clinical and biochemical variables was performed with respect to etiology of AP (biliary versus non-biliary). Multivariate analysis was performed by using binary logistic regression. There were 87 males (59.6%) and 59 females (40.4%), with a median age of 51. The etiology of acute pancreatitis was biliary in 71 patients (48.6%). Bivariate analysis found the following as significant association (p=0.001) with biliary pancreatitis: older age, female gender, and elevated AST, ALT. A binary logistic regression analysis identified as predictor factors for biliary etiology of acute pancreatitis: age OR = 1.031 (95% CI 1.004 - 1.059, p = 0.024), sex (female) OR = 2.34 (95% CI 1.022 - 5.359, p = 0.044) and ALT OR = 1.004 (95% CI 1.001 - 1.007, p =0.004). The two clinical scores included the three variables (A.S.ALT scores) in categorical format were generated and then checked with the ROC curves (areas under curve are 0.768 and 0.778). Age, female gender, and elevated ALT can help identifying cases with biliary etiology of acute pancreatitis.

  3. CASUÍSTICA DE ALTE NUM HOSPITAL TERCIÁRIO – O QUE MUDOU NOS ÚLTIMOS 5 ANOS?

    Directory of Open Access Journals (Sweden)

    Daniel Meireles

    2016-07-01

    Conclusões: O ALTE cursa frequentemente com evolução favorável. Apesar de não haver recomendação ou consensos na literatura para a investigação etiológica, esta mantém-se uma prática comum, sem aparente modificação na abordagem nos últimos anos, em comparação com estudo prévio realizado em 2009.

  4. Preparation of a Sepia Melanin and Poly(ethylene-alt-maleic Anhydride Hybrid Material as an Adsorbent for Water Purification

    Directory of Open Access Journals (Sweden)

    Guido Panzarasa

    2018-01-01

    Full Text Available Meeting the increasing demand of clean water requires the development of novel efficient adsorbent materials for the removal of organic pollutants. In this context the use of natural, renewable sources is of special relevance and sepia melanin, thanks to its ability to bind a variety of organic and inorganic species, has already attracted interest for water purification. Here we describe the synthesis of a material obtained by the combination of sepia melanin and poly(ethylene-alt-maleic anhydride (P(E-alt-MA. Compared to sepia melanin, the resulting hybrid displays a high and fast adsorption efficiency towards methylene blue (a common industrial dye for a wide pH range (from pH 2 to 12 and under high ionic strength conditions. It is easily recovered after use and can be reused up to three times. Given the wide availability of sepia melanin and P(E-alt-MA, the synthesis of our hybrid is simple and affordable, making it suitable for industrial water purification purposes.

  5. Radiation induced, raft mediated grafting of styrene onto poly(ethylene-alt-tetrafluoroethylene) (ETFE)

    International Nuclear Information System (INIS)

    Celik, G.; Barsbay, M.; Gueven, O.

    2011-01-01

    Complete text of publication follows. The development of cost-effective proton exchange membranes to replace the state-of-the-art and expensive perfluorinated membranes such as Nafion, Flemion, and Aciplex is one of the main challenges for commercialization of polymer electrolyte fuel cell technology. Recently, partially fluorinated poly(ethlyene-alt-tetrafluoroethylene) (ETFE) has been identified as a promising alternative base polymer film to prepare low-cost polymer electrolyte membranes because of its advantageous characters like superior mechanical properties and high resistance to radiation-induced damage. The radiation-induced grafting technique, based on the utilization of a polymer material such as ETFE in combination with further chemical modification steps (sulfonation) allows the functionalization of the base material and the introduction of the desired property (proton conductivity) for preparing a fuel cell membrane. However this simple conventional method suffers from one simple flaw: The molecular weight and the polydispersity of the grafted chains cannot be controlled. Predetermined molecular weights and low dispersities as well as homogeneous composition and desired architecture can be achieved by grafting of monomer onto base polymer under living/controlled free radical polymerization (CRP) conditions. Among the CRP methods, Reversible Addition Fragmentation-Chain Transfer (RAFT) is of particular interest as a very wide range of functional monomers can be polymerized in a controlled manner under non-demanding reaction conditions (e.g., tolerance to oxygen and low temperatures). The present study deals with the RAFT mediated radiation-induced (0.032 kGyh -1 , 60 Co) grafting of styrene on ETFE films followed by the sulfonation of the polystyrene grafts. The effect of monomer concentration, absorbed dose and RAFT agent concentration on the grafting were investigated. The synthesized films were characterized by ATR-FTIR, XPS, DSC and TGA methods

  6. A Styrene-alt-Maleic Acid Copolymer Is an Effective Inhibitor of R5 and X4 Human Immunodeficiency Virus Type 1 Infection

    Directory of Open Access Journals (Sweden)

    Vanessa Pirrone

    2010-01-01

    Full Text Available An alternating copolymer of styrene and maleic acid (alt-PSMA differs from other polyanionic antiviral agents in that the negative charges of alt-PSMA are provided by carboxylic acid groups instead of sulfate or sulfonate moieties. We hypothesized that alt-PSMA would have activity against human immunodeficiency virus type 1 (HIV-1 comparable to other polyanions, such as the related compound, poly(sodium 4-styrene sulfonate (PSS. In assays using cell lines and primary immune cells, alt-PSMA was characterized by low cytotoxicity and effective inhibition of infection by HIV-1 BaL and IIIB as well as clinical isolates of subtypes A, B, and C. In mechanism of action assays, in which each compound was added to cells and subsequently removed prior to HIV-1 infection (“washout” assay, alt-PSMA caused no enhancement of infection, while PSS washout increased infection 70% above control levels. These studies demonstrate that alt-PSMA is an effective HIV-1 inhibitor with properties that warrant further investigation.

  7. Politiken, Alt om Ikast Brande (web), Lemvig Folkeblad (Web), Politiken (web), Dabladet Ringkjøbing Skjern (web)

    DEFF Research Database (Denmark)

    Lauritsen, Jens

    2014-01-01

    Politiken 01.01.2014 14:16 Danskerne skød nytåret ind med et brag, men for enkeltes vedkommende gik det galt, da nytårskrudtet blev tændt. Skadestuerne har behandlet 73 personer for fyrværkeriskader mellem klokken 18 i aftes og klokken 06 i morges. Det viser en optælling, som Politiken har...... foretaget på baggrund af tal fra Ulykkes Analyse Gruppen på Odense Universitetshospital. Artiklen er også bragt i: Alt om Ikast Brande (web), Lemvig Folkeblad (web), Politiken (web), Dagbladet Ringkjøbing Skjern (web)....

  8. #whitegenocide, the Alt-right and Conspiracy Theory: How Secrecy and Suspicion Contributed to the Mainstreaming of Hate

    Directory of Open Access Journals (Sweden)

    Andrew F. Wilson,

    2018-02-01

    Full Text Available This article considers the relationship between “hashtag activism” as it is currently being used by the alt-right and the tendency to draw on conspiracy theory that Richard Hofstadter identified as being prevalent among what he termed “pseudo-conservatives” half a century earlier. Both the alt-right and Hofstadter’s “pseudo-conservatives” can be characterised by a pronounced populist nationalism that understands its aims as protecting a particular way of life whilst drawing on an aggrieved sense of injustice at being conspired against by an unseen enemy. That this “enemy” is typically foreign in actuality or in spirit confirms the cultural dimension on which their politics is played out. It is argued here that this paranoid populist nationalism has been figuratively drawn upon in the rhetoric of Donald Trump and that this apparent openness to the “pseudo-conservative” discourse on nationalism has provided a bridging effect via which far right elements are seeking to normalize extremist viewpoints

  9. Frederick W. Alt received the 2015 Szent-Györgi Prize for Progress in Cancer Research.

    Science.gov (United States)

    Scully, Peter; Zhao, Jie; Ba, Sujuan

    2016-02-03

    The Szent-Györgyi Prize for Progress in Cancer Research is a prestigious scientific award established by the National Foundation for Cancer Research (NFCR)--a leading cancer research charitable organization in the United States that is committed to supporting scientific research and public education relating to the prevention, early diagnosis, better treatments, and ultimately, a cure for cancer. Each year, the Szent-Györgyi Prize honors an outstanding researcher, nominated by colleagues or peers, who has contributed outstanding, significant research to the fight against cancer, and whose accomplishments have helped improve treatment options for cancer patients. The Prize also promotes public awareness of the importance of basic cancer research and encourages the sustained investment needed to accelerate the translation of these research discoveries into new cancer treatments. This report highlights the pioneering work led by the 2015 Prize winner, Dr. Frederick Alt. Dr. Alt's work in the area of cancer genetics over four decades has helped to shape the very roots of modern cancer research. His work continues to profoundly impact the approaches that doctors around the globe use to diagnose and treat cancer. In particular, his seminal discoveries of gene amplification and his pioneering work on molecular mechanisms of DNA damage repair have helped to usher in the era of genetically targeted therapy and personalized medicine.

  10. ELEVATED ALANINE AMINOTRANSFERASE (ALT IN BLOOD DONORS: AN ASSESSMENT OF THE MAIN ASSOCIATED CONDITIONS AND ITS RELATIONSHIP TO THE DEVELOPMENT OF HEPATITIS C

    Directory of Open Access Journals (Sweden)

    Fernando Lopes GONÇALES Jr.

    1998-07-01

    Full Text Available The determination of aminotranferases levels is very useful in the diagnosis of hepatopathies. In recent years, an elevated serum ALT level in blood donors has been associated with an increased risk of post-transfusion hepatitis (PTH. The purpose of the study was to research the factors associated with elevated ALT levels in a cohort of voluntary blood donors and to evaluate the relationship between increased ALT levels and the development of hepatitis C (HCV infection. 166 volunteer blood donors with elevated ALT at the time of their first donation were studied. All of the donors were questioned about previous hepatopathies, exposure to hepatitis, exposure to chemicals, use of medication or drugs, sexual behaviour, contact with blood or secretions and their intake of alcohol. Every three months, the serum levels of AST, ALT, alkaline phosphatase, gamma glutamyl transpeptidase, cholesterol, triglyceride and glycemia are assessed over a two year follow-up. The serum thyroid hormone levels as well as the presence of auto-antibodies were also measured. Abdominal ultrasound was performed in all patients with persistently elevated ALT or AST levels. A needle biopsy of liver was performed in 9 donors without definite diagnostic after medical investigation. The presence of anti-HCV antibodies in 116 donors were assayed again the first clinical evaluation. At the end of follow-up period (2 years later 71 donors were tested again for the presence of anti-HCV antibodies. None of donors resulted positive for hepatitis B or hepatitis C markers during the follow-up. Of the 116 donors, 101 (87% had persistently elevated ALT serum levels during the follow-up. Obesity and alcoholism were the principal conditions related to elevated ALT serum levels in 91/101 (90.1% donors. Hypertriglyceridemia, hypercholesterolemia, hypothyroidism and diabetes mellitus also were associated with increased ALT levels. Only 1/101 (0.9% had mild chronic active non A-G viral

  11. Preserved GLP-1 and exaggerated GIP secretion in type 2 diabetes and relationships with triglycerides and ALT

    DEFF Research Database (Denmark)

    Alssema, Marjan; Rijkelijkhuizen, Josina M; Holst, Jens Juul

    2013-01-01

    OBJECTIVE: To i) compare incretin responses to oral glucose and mixed meal of diabetic patients with the normoglycaemic population and ii) to investigate whether incretin responses are associated with hypertriglyceridaemia and alanine aminotransferase (ALT) as liver fat marker. DESIGN: A population......-based study. METHODS: A total of 163 persons with normal glucose metabolism (NGM), 20 with intermediate hyperglycaemia and 20 with type 2 diabetes aged 40-65 years participated. Participants received a mixed meal and oral glucose load on separate occasions. Glucagon-like peptide 1 (GLP-1), glucose......-dependent insulinotropic polypeptide (GIP) and glucagon profiles were analysed as total area under the curve (tAUC) and incremental area under the curve. RESULTS: In diabetic patients compared with persons with NGM, we found increased GLP-1 secretion (tAUC per hour) following oral glucose (23.2 pmol/l (95% CI 17...

  12. Chitosan: poly(N-vinylpyrrolidone-alt-itaconic anhydride) nanocapsules—a promising alternative for the lung cancer treatment

    Energy Technology Data Exchange (ETDEWEB)

    Raţă, Delia Mihaela, E-mail: iureadeliamihaela@yahoo.com [„Apollonia” University of Iasi, Faculty of Medical Dentistry, „Academician Ioan Haulică” Research Institute (Romania); Chailan, Jean-François, E-mail: chailan@univ-tln.fr [University of Sud Toulon-Var, « Matériaux-Polymères-Interfaces-Environnement Marin (MAPIEM) Laboratory (France); Peptu, Cătălina Anişoara, E-mail: catipeptu@yahoo.co.uk [“Gheorghe Asachi” Technical University of Iasi, Department of Natural and Synthetic Polymers, Faculty of Chemical Engineering and Environmental Protection (Romania); Costuleanu, Marcel, E-mail: mcostuleanu@yahoo.com [University of Medicine and Pharmacy “Grigore T. Popa”- Iaşi, Department of General Pathology, Faculty of Dental Medicine (Romania); Popa, Marcel, E-mail: marpopa2001@yahoo.fr [“Gheorghe Asachi” Technical University of Iasi, Department of Natural and Synthetic Polymers, Faculty of Chemical Engineering and Environmental Protection (Romania)

    2015-07-15

    This study reports the preparation of novel polymeric nanocapsules based on a natural polymer, chitosan and a synthetic one, poly(N-vinylpyrrolidone-alt-itaconic anhydride) [(poly(NVPAI)] using an interfacial condensation technique. The infrared spectroscopy studies confirmed the crosslinking through the presence of amide bonds, formed between the two polymers chains. The diameter of nanocapsules was found in the range of 126–214 nm and it was determined by dynamic light scattering method. Morphological characterization demonstrated their nano size, the spherical shape of the nanocapsules and the formation of hollow particles. The nanocapsules presented good swelling capacity in aqueous solutions. 5-Fluorouracil (5-FU) loading and release capacity was studied, the processes being controlled by the drug diffusion through the polymeric membrane. The obtained results were encouraging, showing that 5-FU-loaded nanocapsules had 70 % higher apoptotic effect on A549 tumour cells than the drug in free state or mixed with the nanocapsules.

  13. Grafting amino drugs to poly(styrene-alt-maleic anhydride) as a potential method for drug release

    Energy Technology Data Exchange (ETDEWEB)

    Khazaei, Ardeshir; Saednia, Shahnaz; Saien, Javad; Abbasi, Fatemeh, E-mail: Khazaei_1326@yahoo.com, E-mail: ssaednia@gmail.com [Faculty of Chemistry, Bu-Ali Sina University, Hamedan (Iran, Islamic Republic of); Kazem-Rostami, Masoud [Young Researchers Club and Elite, Takestan Branch, Islamic Azad University, Takestan (Iran, Islamic Republic of); Sadeghpour, Mahdieh [Department of Chemistry, Takestan Branch, Islamic Azad University, Takestan (Iran, Islamic Republic of); Borazjani, Maryam Kiani [Faculty of Science, Department of Chemistry, Bushehr Payame Noor University (PNU), Bushehr (Iran, Islamic Republic of)

    2013-07-15

    Drug delivery systems based on polymer-drug conjugates give an improved treatment with lower toxicity or side effects and be used for the treatment of different diseases. Conjugates of biodegradable poly(styrene-alt-maleic anhydride) (PSMA), with a therapeutic agents such as amantadine hydrochloride, amlodipine, gabapentin, zonisamide and mesalamine, were afforded by the formation of the amide bonds of the amino drugs that reacted with the PSMA anhydride groups. The amounts of covalently conjugated drugs were determined by a {sup 1}H NMR spectroscopic method, and the in vitro release rate in buffer solution (pH 1.3) was studied at body temperature 37 Degree-Sign C. In kinetic studies, different dissolution models were examined to obtain drug release data and the collected data were well-fitted to the Korsmeyer-Peppas equation, revealing a dominant Fickian diffusion mechanism for drug release under the in vitro conditions. (author)

  14. Chitosan: poly( N-vinylpyrrolidone- alt-itaconic anhydride) nanocapsules—a promising alternative for the lung cancer treatment

    Science.gov (United States)

    Raţă, Delia Mihaela; Chailan, Jean-François; Peptu, Cătălina Anişoara; Costuleanu, Marcel; Popa, Marcel

    2015-07-01

    This study reports the preparation of novel polymeric nanocapsules based on a natural polymer, chitosan and a synthetic one, poly( N-vinylpyrrolidone- alt-itaconic anhydride) [(poly(NVPAI)] using an interfacial condensation technique. The infrared spectroscopy studies confirmed the crosslinking through the presence of amide bonds, formed between the two polymers chains. The diameter of nanocapsules was found in the range of 126-214 nm and it was determined by dynamic light scattering method. Morphological characterization demonstrated their nano size, the spherical shape of the nanocapsules and the formation of hollow particles. The nanocapsules presented good swelling capacity in aqueous solutions. 5-Fluorouracil (5-FU) loading and release capacity was studied, the processes being controlled by the drug diffusion through the polymeric membrane. The obtained results were encouraging, showing that 5-FU-loaded nanocapsules had 70 % higher apoptotic effect on A549 tumour cells than the drug in free state or mixed with the nanocapsules.

  15. Chitosan: poly(N-vinylpyrrolidone-alt-itaconic anhydride) nanocapsules—a promising alternative for the lung cancer treatment

    International Nuclear Information System (INIS)

    Raţă, Delia Mihaela; Chailan, Jean-François; Peptu, Cătălina Anişoara; Costuleanu, Marcel; Popa, Marcel

    2015-01-01

    This study reports the preparation of novel polymeric nanocapsules based on a natural polymer, chitosan and a synthetic one, poly(N-vinylpyrrolidone-alt-itaconic anhydride) [(poly(NVPAI)] using an interfacial condensation technique. The infrared spectroscopy studies confirmed the crosslinking through the presence of amide bonds, formed between the two polymers chains. The diameter of nanocapsules was found in the range of 126–214 nm and it was determined by dynamic light scattering method. Morphological characterization demonstrated their nano size, the spherical shape of the nanocapsules and the formation of hollow particles. The nanocapsules presented good swelling capacity in aqueous solutions. 5-Fluorouracil (5-FU) loading and release capacity was studied, the processes being controlled by the drug diffusion through the polymeric membrane. The obtained results were encouraging, showing that 5-FU-loaded nanocapsules had 70 % higher apoptotic effect on A549 tumour cells than the drug in free state or mixed with the nanocapsules

  16. Altıntop Dilim Konservesi Üretiminde Enzim Kullanımı: I. Kabuk Soyma

    Directory of Open Access Journals (Sweden)

    Osman Kola

    2015-02-01

    Full Text Available Bu çalışmada; altıntop dilim konservesi yapımında kabuk soyma ve dilim zarının uzaklaştırılması amaçlarıyla enzim çözeltisi kullanılmasının etkileri araştırılmıştır. Bunun için: önce, çözeltinin meyve kabuğu içine nüfuz ettirilmesi amacıyla uygulanabilecek uygun işlemler, sonra da, enzim çözeltisi uygulamasının kabuk soyma işlemleri üzerindeki etkileri araştırılmıştır. Kabuk soyma işleminde meyvenin; 95 °C sıcaklıktaki suda 5 dakika bekletildikten sonra kapak açma ve kabuk çizme işlemlerini takiben, su ya da %0.5 düzeyindeki Peelzym II çözeltisi içine konulan meyvelerin 1.76 kg/cm2 (25 psi basınç altında 60 saniye süreyle işleme tabi tutulmasının, hem işlemin etkinliği hem de son ürünün kalitesi açısından uygun olabileceği sonucuna varılmıştır.

  17. PDMS-modified poly(styrene-alt-maleic anhydride)s as water-borne coatings based on surfactant-free latexes

    NARCIS (Netherlands)

    Gunbas, I.D.; Wouters, M.E.L.; Benthem, R.A.T.M. van; Koning, C.E.; Noordover, B.A.J.

    2013-01-01

    In this work, two series of PDMS-modified poly(styrene-alt-maleic anhydride)s (PSMA) were prepared by the partial imidization of their anhydride groups with mono-functional, amine-terminated polydimethyl siloxanes (PDMS-NH2) with two different molecular weights. Subsequently, surfactant-free

  18. Potential of Red Spinach Leaves Ethanolic Extract (Amaranthus tricolor L. as a Complementary Therapy For Hiperlipidemia: Study in Vivo of Histopathologic and Activity of Alanin Aminotransferase (ALT

    Directory of Open Access Journals (Sweden)

    Dimas Adhi Pradana

    2016-12-01

    Full Text Available This study was conducted to determine the potential of ethanolic extract of red spinach leaves (Amaranthus tricolor L. with control quality as a complementary treatment of hyperlipidemic based on histopathology and activity of alanin aminotrasferase (ALT. A total of 24 male Wistar rats were randomized in 6 groups: normal group; positive control group were given the drug simvastatin; negative control group; 1st treatment group was given extract at dose of 400mg/kgBW rat, 2nd group was given extract at dose of 400mg/kgBW rat and simvastatin dose 0.18 mg/kgBW rat; 3rd treatment groups were given extract at dose of 800mg/kgBW rat and simvastatin dose 0.18 mg/kgBW rat. Induction hyperlipidemic using high fat diet and poloxamer. The data obtained were tested normality with the Shapiro-Wilk test. Statistical analysis using Oneway ANOVA and Post-Hoc Tukey HSD to determine the significance of differences between groups for ALT parameter. Result show the use of ethanolic extract of red spinach leaves can reduce fatty liver condition based on decreased level of ALT and liver histopathologic. It is concluded that the ethanolic extract of red spinach leaves dose 400mg/kgBW rat combine with simvastatin can reduce activity of ALT until 31.57 U1-1.

  19. Feedback on the Inaugural Meeting of the Cost 347 Accelerated Loading Test (ALT) Action in Europe: June 27th to 29th 2001

    CSIR Research Space (South Africa)

    De Beer, Morris

    2001-11-01

    Full Text Available . The author presented two topics, i.e. Accelerated Pavement Testing (APT) in South Africa, and Stress-In-Motion (SIM). This COST 347 action started in October 2001, and needs to deliver recommendations on ALT April 2004. There are 6 Working Groups, chaired...

  20. LIMITED ELEVATIONS IN ANTITUBERCULOSIS DRUG-INDUCED SERUM ALANINE AMINOTRANSFERASE (ALT) LEVELS IN A COHORT OF NIGERIANS ON TREATMENT FOR PULMONARY TUBERCULOSIS AND HIV INFECTION IN YENAGOA

    NARCIS (Netherlands)

    Ikuabe, Peter Ogie; Ebuenyi, Ikenna Desmond; Harry, Tubonye Clement

    2015-01-01

    BACKGROUND: This study, undertaken in a major tertiary hospital in the Niger Delta region of Nigeria was designed to examine the incidence of elevation in serum alanine aminotransference (ALT) in our patients who were on treatment for HIV/AIDS with some of them on antituberculosis drugs. METHOD:

  1. Alternagin-C (ALT-C), a disintegrin-like protein from Rhinocerophis alternatus snake venom promotes positive inotropism and chronotropism in fish heart.

    Science.gov (United States)

    Monteiro, D A; Kalinin, A L; Selistre-de-Araujo, H S; Vasconcelos, E S; Rantin, F T

    2016-02-01

    Alternagin-C (ALT-C) is a disintegrin-like protein purified from the venom of the snake, Rhinocerophis alternatus. Recent studies showed that ALT-C is able to induce vascular endothelial growth factor (VEGF) expression, endothelial cell proliferation and migration, angiogenesis and to increase myoblast viability. This peptide, therefore, can play a crucial role in tissue regeneration mechanisms. The aim of this study was to evaluate the effects of a single dose of alternagin-C (0.5 mg kg(-1), via intra-arterial) on in vitro cardiac function of the freshwater fish traíra, Hoplias malabaricus, after 7 days. ALT-C treatment increased the cardiac performance promoting: 1) significant increases in the contraction force and in the rates of contraction and relaxation with concomitant decreases in the values of time to the peak tension and time to half- and 90% relaxation; 2) improvement in the cardiac pumping capacity and maximal electrical stimulation frequency, shifting the optimum frequency curve upward and to the right; 3) increases in myocardial VEGF levels and expression of key Ca(2+)-cycling proteins such as SERCA (sarcoplasmic reticulum Ca(2+)-ATPase), PLB (phospholamban), and NCX (Na(+)/Ca(2+) exchanger); 4) abolishment of the typical negative force-frequency relationship of fish myocardium. In conclusion, this study indicates that ALT-C improves cardiac function, by increasing Ca(2+) handling efficiency leading to a positive inotropism and chronotropism. The results suggest that ALT-C may lead to better cardiac output regulation indicating its potential application in therapies for cardiac contractile dysfunction. Copyright © 2015 Elsevier Ltd. All rights reserved.

  2. Predictive value of serum ALT and T-cell receptor beta variable chain for HBeAg seroconversion in chronic hepatitis B patients during tenofovir treatment.

    Science.gov (United States)

    Yang, Jiezuan; Yan, Dong; Guo, Renyong; Chen, Jiajia; Li, Yongtao; Fan, Jun; Fu, Xuyan; Yao, Xinsheng; Diao, Hongyan; Li, Lanjuan

    2017-03-01

    Effective antiviral therapy plays a key role in slowing the progression of chronic hepatitis B (CHB). Identification of serum indices, including hepatitis B e antigen (HBeAg) expression and seroconversion, will facilitate evaluation of the efficacy of antiviral therapy in HBeAg-positive CHB patients. The biochemical, serological, virological parameters, and the frequency of circulating CD4CD25 regulatory T cell (Treg) in 32 patients were measured at baseline and every 12 weeks during 96 weeks of tenofovir disoproxil fumarate (TDF) treatment. The relationship between the hepatitis B virus (HBV) deoxyribonucleic acid (DNA) and Treg and alanine aminotransferase (ALT) levels was analyzed, respectively. The molecular profiles of T-cell receptor beta variable chain (TRBV) were determined using gene melting spectral pattern. For the seroconverted 12 patients, ALT declined to normal levels by week 24 and remained at this level in subsequent treatment; moreover, the predictive cutoff value of ALT for HBeAg seroconversion (SC) was 41.5 U/L at week 24. The positive correlation between HBV DNA and Treg and ALT was significant in SC patients, but not in non-SC patients. Six TRBV families (BV3, BV11, BV12, BV14, BV20, and BV24) were predominantly expressed in SC patients at baseline. The decline of ALT could be used to predict HBeAg seroconversion for CHB patients during TDF treatment. In addition, the profile of Tregs and TRBVs may be associated with HBeAg seroconversion and could also be a potential indicator for predicting HBeAg SC and treatment outcome for CHB patients.

  3. Energy Level Tuning of Poly(phenylene-alt-dithienobenzothiadiazole)s for Low Photon Energy Loss Solar Cells.

    Science.gov (United States)

    Heuvel, Ruurd; van Franeker, Jacobus J; Janssen, René A J

    2017-03-01

    Six poly(phenylene- alt -dithienobenzothiadiazole)-based polymers have been synthesized for application in polymer-fullerene solar cells. Hydrogen, fluorine, or nitrile substitution on benzo-thiadiazole and alkoxy or ester substitution on the phenylene moiety are investigated to reduce the energy loss per converted photon. Power conversion efficiencies (PCEs) up to 6.6% have been obtained. The best performance is found for the polymer-fullerene combination with distinct phase separation and crystalline domains. This improves the maximum external quantum efficiency for charge formation and collection to 66%. The resulting higher photocurrent compensates for the relatively large energy loss per photon ( E loss = 0.97 eV) in achieving a high PCE. By contrast, the poly-mer that provides a reduced energy loss ( E loss = 0.49 eV) gives a lower photocurrent and a reduced PCE of 1.8% because the external quantum efficiency of 17% is limited by a suboptimal morphology and a reduced driving force for charge transfer.

  4. Separator Membrane from Crosslinked Poly(Vinyl Alcohol and Poly(Methyl Vinyl Ether-alt-Maleic Anhydride

    Directory of Open Access Journals (Sweden)

    Charu Vashisth Rohatgi

    2015-03-01

    Full Text Available In this work, we report separator membranes from crosslinking of two polymers, such as poly vinyl alcohol (PVA with an ionic polymer poly(methyl vinyl ether-alt-maleic anhydride (PMVE-MA. Such interpolymer-networked systems were extensively used for biomedical and desalination applications but they were not examined for their potential use as membranes or separators for batteries. Therefore, the chemical interactions between these two polymers and the influence of such crosslinking on physicochemical properties of the membrane are systematically investigated through rheology and by critical gel point study. The hydrogen bonding and the chemical interaction between PMVE-MA and PVA resulted in highly cross-linked membranes. Effect of the molecular weight of PVA on the membrane properties was also examined. The developed membranes were extensively characterized by studying their physicochemical properties (water uptake, swelling ratio, and conductivity, thermal and electrochemical properties using differential scanning calorimetry (DSC, dynamic mechanical analysis (DMA, thermo-gravimetric analysis (TGA and electrochemical impedance spectroscopy (EIS. The DSC study shows the presence of a single Tg in the membranes indicating compatibility of the two polymers in flexible and transparent films. The membranes show good stability and ion conductivity suitable for separator applications.

  5. Separator Membrane from Crosslinked Poly(Vinyl Alcohol) and Poly(Methyl Vinyl Ether-alt-Maleic Anhydride)

    Science.gov (United States)

    Rohatgi, Charu Vashisth; Dutta, Naba K.; Choudhury, Namita Roy

    2015-01-01

    In this work, we report separator membranes from crosslinking of two polymers, such as poly vinyl alcohol (PVA) with an ionic polymer poly(methyl vinyl ether-alt-maleic anhydride) (PMVE-MA). Such interpolymer-networked systems were extensively used for biomedical and desalination applications but they were not examined for their potential use as membranes or separators for batteries. Therefore, the chemical interactions between these two polymers and the influence of such crosslinking on physicochemical properties of the membrane are systematically investigated through rheology and by critical gel point study. The hydrogen bonding and the chemical interaction between PMVE-MA and PVA resulted in highly cross-linked membranes. Effect of the molecular weight of PVA on the membrane properties was also examined. The developed membranes were extensively characterized by studying their physicochemical properties (water uptake, swelling ratio, and conductivity), thermal and electrochemical properties using differential scanning calorimetry (DSC), dynamic mechanical analysis (DMA), thermo-gravimetric analysis (TGA) and electrochemical impedance spectroscopy (EIS). The DSC study shows the presence of a single Tg in the membranes indicating compatibility of the two polymers in flexible and transparent films. The membranes show good stability and ion conductivity suitable for separator applications. PMID:28347019

  6. La incidencia de la helada de 1956 en el Olivar de Navata (Alt Empordà, Girona

    Directory of Open Access Journals (Sweden)

    Sandra Ricart Casadevall

    2009-01-01

    Full Text Available En la comarca del Alt Empordà (Girona, el olivar ha configurado históricamente un paisaje de alto valor económico, cultural y ambiental si bien desde mediados del siglo XX se encuentra en fuerte regresión. Uno de los municipios situados en el límite de la plana altoampurdanesa que mejor ejemplifican este proceso de abandono y casi desaparición del olivar es Navata. Este artículo analiza los cambios experimentados en el olivar de este municipio en el periodo 1957-2004 a través tanto de la elaboración de una cartografía de usos y cubiertas del suelo a escala de detalle como del análisis de fuentes estadísticas y orales, ejercicio que pone de relieve la pérdida del 90% del olivar existente a mediados del siglo pasado. La helada de febrero de 1956 fue uno de los principales causantes, pero no el único. Sin embargo, tanto la importancia del olivar como elemento identitario y de conservación de la biodiversidad como el carácter diferenciador del aceite que se obtiene a partir de variedades propias de la zona (especialmente la argudell, justifican la necesidad de impulsar políticas que ayuden a su recuperación.

  7. Thermal load distribution on the ALT-II limiter of TEXTOR-94 during RI mode operation and during disruptions

    International Nuclear Information System (INIS)

    Finken, K.H.; Denner, T.; Mank, G.

    2000-01-01

    Thermographic measurements using an IR scanner have been performed at the pump limiter ALT-II of TEXTOR-94 during RI mode discharges and during disruptions. The measurements on the RI mode discharges were done to complete the TEXTOR database which had shown a structured decay pattern of the deposited power. It was found that the underlying radial heat flux can be described by two exponential decay functions. This structure, which generates an unexpected heat component close to the tangent line, has been observed in all discharge conditions including the RI mode. During disruptions, the heat is released in short pulses with a typical duration of 0.01-0.1 ms. The radial decay length of these pulses has a similar shape to the heat flux during normal discharges: it consists again of a strong component close to the tangent line with a radial decay length of 2-5 mm and probably one with a decay length of the order of 1 cm. The heat is released at the time when the edge electron temperature of the plasma drops, when intense hydrogen and carbon fluxes occur near the walls, and when electrical currents in the limiter blades are excited. In a tentative interpretation, the temporal and spatial structure of the heat pulse is attributed to the presence and growth of a laminar zone at the plasma edge, which is connected with the ergodization of the plasma edge during a disruption. (author)

  8. Solvent effect on post-irradiation grafting of styrene onto poly(ethylene-alt-tetrafluoroethylene) (ETFE) films

    Science.gov (United States)

    Napoleão Geraldes, Adriana; Augusto Zen, Heloísa; Ribeiro, Geise; Fernandes Parra, Duclerc; Benévolo Lugão, Ademar

    2013-03-01

    Radiation-induced grafting of styrene onto ETFE films in different solvent was investigated after simultaneous irradiation (in post-irradiation condition) using a 60Co source. Grafting of styrene followed by sulfonation onto poly(ethylene-alt-tetrafluoroethylene) (ETFE) are currently studied for synthesis of ion exchange membranes. The ETFE films were immersed in styrene/toluene, styrene/methanol and styrene/isopropyl alcohol and irradiated at 20 and 100 kGy doses at room temperature. The post-irradiation time was established at 14 day and the grafting degree was evaluated. The grafted films were sulfonated using chlorosulfonic acid and 1,2-dichloroethane 20:80 (v/v) at room temperature for 5 h. The degree of grafting (DOG) was determined gravimetrically and physical or chemical changes were evaluated by differential scanning calorimeter analysis (DSC), thermogravimetric analysis (TGA) and scanning electron microscopy (SEM). The ion exchange capacity (IEC) values showed the best performance of sulfonation for ETFE membranes grafted in toluene solvent. Surface images of the grafted films by SEM technique have presented a strong effect of the solvents on the films morphology.

  9. The Magnaporthe oryzae Alt A 1-like protein MoHrip1 binds to the plant plasma membrane.

    Science.gov (United States)

    Zhang, Yi; Liang, Yingbo; Dong, Yijie; Gao, Yuhan; Yang, Xiufen; Yuan, Jingjing; Qiu, Dewen

    2017-10-07

    MoHrip1, a protein isolated from Magnaporthe oryzae, belongs to the Alt A 1 (AA1) family. mohrip1 mRNA levels showed inducible expression throughout the infection process in rice. To determine the location of MoHrip1 in M. oryzae, a mohrip1-gfp mutant was generated. Fluorescence microscopy observations and western blotting analysis showed that MoHrip1 was both present in the secretome and abundant in the fungal cell wall. To obtain MoHrip1 protein, we carried out high-yield expression of MoHrip1 in Pichia pastoris. Treatment of tobacco plants with MoHrip1 induced the formation of necrosis, accumulation of reactive oxygen species and expression of several defense-related genes, as well as conferred disease resistance. By fusion to green fluorescent protein, we showed that MoHrip1 was able to bind to the tobacco and rice plant plasma membrane, causing rapid morphological changes at the cellular level, such as cell shrinkage and chloroplast disorganization. These findings indicate that MoHrip1 is a microbe-associated molecular pattern that is perceived by the plant immune system. This is the first study on an AA1 family protein that can bind to the plant plasma membrane. Copyright © 2017 Elsevier Inc. All rights reserved.

  10. Ethnobotany of the Alt Empordà region (Catalonia, Iberian Peninsula): plants used in human traditional medicine.

    Science.gov (United States)

    Parada, Montse; Carrió, Esperança; Bonet, Maria Angels; Vallès, Joan

    2009-07-30

    This paper provides significant ethnobotanical information on pharmaceutical plant uses from a tourist and industrialised region, where some degree of acculturation exists, so that there is urgency in recording such data. To collect, analyze and evaluate the ethnobotanical knowledge about medicinal plants in a north-eastern Iberian region (Alt Empordà, 1358 km(2), 129,160 inhabitants). We performed 101 semi-structured interviews with 178 informants (mean age 69; 71% women, 29% men), identified the plant taxa reported and analyzed the results, comparing them with those from other territories. The informants reported data on 518 species. Of these, 335, belonging to 80 botanical families, were claimed as medicinal. This work is focused on human medicinal plant uses, which represent 98% of the pharmaceutical uses (3581 out of 3643 use reports). Around 800 medicinal uses, concerning 200 species, have not, or have very rarely been cited as medicinal; of these, 32 uses of 30 species have been reported by three or more independent informants. The folk knowledge about medicinal plant use is still alive in the studied region, and a number of scarcely reported plant uses has been detected, some of them with promising phytotherapeutical applications.

  11. Data on three-year pesticide monitoring in ditches of the apple orchard region of Altes Land, Germany

    Directory of Open Access Journals (Sweden)

    Stefan Lorenz

    2018-06-01

    Full Text Available The data presented in this article are related to the research article 'Chemical and biological monitoring of the load of plant protection products and of zoocoenoses in ditches of the orchard region Altes Land' (Süß et al., 2006 [1], which is only available in the German language. The pesticide data presented here were acquired from four ditches (three ditches were located in apple orchards, and one ditch was located in a grassland region between 2001 and 2003 (Lorenz et al., 2018 [2]. Two different monitoring strategies were applied: event-driven sampling after pesticide applications and weekly integrated sampling using automatic water samplers. A total of 70 active substances were monitored while farmers applied 25 active substances. This article describes the study sites and the analytical methods used to quantify the pesticides in the water samples. The field data set is publicly available at the OpenAgrar repository under https://doi.org/10.5073/20180213-144359 (Lorenz et al., 2018 [2].

  12. Prevalence of epilepsy and seizure disorders as causes of apparent life- threatening event (ALTE in children admitted to a tertiary hospital Prevalência de epilepsia e crises epilépticas como causa de eventos com aparente risco de vida (ALTE em crianças internadas em hospital terciário

    Directory of Open Access Journals (Sweden)

    Alessandra Marques dos Anjos

    2009-09-01

    Full Text Available OBJECTIVE: To determine the prevalence and describe clinical characteristics of seizure disorders and epilepsy as causes of apparent life- threatening event (ALTE in children admitted at the emergency and followed in a tertiary hospital. METHOD: Cross-sectional study with prospective data collection using specific guidelines to determine the etiology of ALTE. RESULTS: During the study, 30 (4.2% children admitted to the hospital had a diagnosis of ALTE. There was a predominance of males (73% and term infants (70%. Neonatal neurological disorders and neuropsychomotor development delay were found respectively in 13.4% and 10% of the cases. Etiological investigation revealed that 50% of the cases were idiopathic, and 13.4% were caused by epilepsy or seizure disorders. Although all patients had recurrent ALTE events, epilepsy had not been previously suspected. CONCLUSION: Epilepsy should be included in the differential diagnosis of ALTE, particularly when events are recurrent.OBJETIVO: Determinar a prevalência e características clínicas de crises epilépticas e epilepsia como causa de eventos com aparente risco de vida (ALTE em crianças atendidas na emergência e acompanhadas em hospital terciário. MÉTODO: Estudo transversal com coleta prospectiva de dados através de protocolo específico para identificação da etiologia de ALTE. RESULTADOS: Foram diagnosticadas 30 crianças com ALTE perfazendo 4.2% das crianças internadas no período do estudo. Houve predominância no sexo masculino (73% e em neonatos a termo (70%. História prévia de doenças neurológicas no período neonatal e atraso no desenvolvimento neuropsicomotor ocorreram respectivamente em 13.4% e 10% dos casos. A investigação etiológica identificou 13.4% dos casos relacionados a epilepsia ou crise convulsivas e 50% idiopáticos. Apesar destes pacientes terem apresentados episódios recorrentes em nenhum caso havia a suspeita prévia de epilepsia. CONCLUSÃO: Ao investigar

  13. Alt koster 10 kr

    DEFF Research Database (Denmark)

    Ejersbo, Lisser Rye

    2014-01-01

    Jeg havde engang en elev, som fortalte, at når han gik i byen for at købe ind, så var det nemt at beregne, om han havde nok penge med i byen. Han sagde bare, at alle varerne kun kostede 10 kr. Det kan lyde som lidt af en tilsnigelse, så klassen og jeg besluttede at undersøge om hans metode virkede....

  14. Astrofisica delle alte energie

    CERN Document Server

    Vietri, Mario

    2006-01-01

    L'insegnamento dell'astrofisica moderna richiede conoscenze di base di svariate discipline, oltre ad alcuni modelli fondamentali. Lo scopo di questo libro è di presentare sia le une che gli altri in maniera possibilmente esaustiva, e di essere dunque utilizzabile sia come prima introduzione alle problematiche astrofisiche, sia come testo di riferimento ulteriore per giovani studiosi.

  15. Riget - alt er tilladt

    DEFF Research Database (Denmark)

    2017-01-01

    Riget indtager en nøglestilling, når overgangen mellem faser i Triers produktion skal karakteriseres. Riget danner bro mellem den billedfascination og de radikale stileksperimenter, der præger Triers tidlige produktion, og den genre- og plotbevidsthed, der er typisk for film som Breaking the Waves...

  16. Performance of an Optimized Paper-Based Test for Rapid Visual Measurement of Alanine Aminotransferase (ALT in Fingerstick and Venipuncture Samples.

    Directory of Open Access Journals (Sweden)

    Sidhartha Jain

    Full Text Available A paper-based, multiplexed, microfluidic assay has been developed to visually measure alanine aminotransferase (ALT in a fingerstick sample, generating rapid, semi-quantitative results. Prior studies indicated a need for improved accuracy; the device was subsequently optimized using an FDA-approved automated platform (Abaxis Piccolo Xpress as a comparator. Here, we evaluated the performance of the optimized paper test for measurement of ALT in fingerstick blood and serum, as compared to Abaxis and Roche/Hitachi platforms. To evaluate feasibility of remote results interpretation, we also compared reading cell phone camera images of completed tests to reading the device in real time.96 ambulatory patients with varied baseline ALT concentration underwent fingerstick testing using the paper device; cell phone images of completed devices were taken and texted to a blinded off-site reader. Venipuncture serum was obtained from 93/96 participants for routine clinical testing (Roche/Hitachi; subsequently, 88/93 serum samples were captured and applied to paper and Abaxis platforms. Paper test and reference standard results were compared by Bland-Altman analysis.For serum, there was excellent agreement between paper test and Abaxis results, with negligible bias (+4.5 U/L. Abaxis results were systematically 8.6% lower than Roche/Hitachi results. ALT values in fingerstick samples tested on paper were systematically lower than values in paired serum tested on paper (bias -23.6 U/L or Abaxis (bias -18.4 U/L; a correction factor was developed for the paper device to match fingerstick blood to serum. Visual reads of cell phone images closely matched reads made in real time (bias +5.5 U/L.The paper ALT test is highly accurate for serum testing, matching the reference method against which it was optimized better than the reference methods matched each other. A systematic difference exists between ALT values in fingerstick and paired serum samples, and can be

  17. Darbe Yükü Altındaki Hibrit Kompozit Plakalara Sıcaklığın Etkisi

    Directory of Open Access Journals (Sweden)

    Metin SAYER

    2009-03-01

    Full Text Available Bu çalışmada, karbon-cam elyaf/epoksi (hibrit kompozitlerin sıcaklık ve artan darbe enerjisi altındaki darbe davranışları incelenmiştir. Bununla ilgili olarak iki tip tabaka dizilim açısına sahip, 8 tabakalı hibrit kompozit numunelere -20, 0, 20 ve 40 oC sıcaklıklarında, numunelerde delinme meydana gelene kadar darbe enerjisi uygulanmıştır. Hibrit kompozitlerin saplanma ve delinme sınır değerlerinin belirlenmesinde, darbe enerjisi ve absorbe edilen enerji arasındaki ilişkiyi göstermede kullanılan enerji profili diyagramı kullanılmıştır. Bunun yanı sıra, maksimum temas kuvveti (Fmax, toplam çökme (d ve maksimum temas süresi (t gibi önemli darbe karakteristiklerinin sıcaklık geçişlerindeki değişimleri de sunulmuştur. Sonuç olarak, cam ve karbon fiberlerin -20 oC'de, diğer sıcaklıklara göre daha çok gevrekleştiği görülmüştür. Buna göre her iki tip hibrit kompozit için -20 oC'de meydana gelen delinme sınırı diğer sıcaklıklara göre en yüksek değerde bulunmuştur.

  18. Altın Fiyatlarının Yapay Sinir Ağları ile Tahmini ve Bir Uygulama

    Directory of Open Access Journals (Sweden)

    Rıdvan YÜKSEL

    2016-03-01

    Full Text Available Bu çalışmada altın fiyatlarını yapay sinir ağları ile öngörmek amacıyla, altın fiyatlarını etkileyebileceği düşünülen değişkenler olan Gümüş fiyatları, Brent Petrol fiyatları, ABD doları/ EUR paritesi, EuroNext100 endeksi, Amerika Dow Jones Endeksi, 13 Hafta vadeli ABD bonosu faiz oranı ve ABD TÜFE endeksi kullanılarak modeller kurulmuştur. Yapay sinir ağları ile kurulan modellerden elde edilen tahmin sonuçları, gerçek değerler ile R2, RMSE, MAE ve MAPE (% gibi performans kriterleri hesaplanarak karşılaştırılmıştır. Elde edilen bulgular yapay sinir ağlarının altın fiyatlarının tahmininde başarı ile kullanılabileceğini göstermektedir. Yapılan duyarlılık analizinin sonuçları değerlendirildiğinde altın fiyatlarını etkileyen faktörlerin başında gümüş ve petrol fiyatlarının geldiği tespit edilmiştir.

  19. La sémantique du stereotype et la representation topique de l’altérité

    Directory of Open Access Journals (Sweden)

    Afsaneh Pourmazaheri

    2017-12-01

    Full Text Available Ce travail de recherche s’interroge sur la représentation discursive des référents exotiques filtrée par un regard stéréotypé dans les récits de trois voyageurs français en Orient de la première moitié du XIXe siècle. Les énonciateurs-voyageurs, placés dans un contexte linguistique et culturel asymétrique, tentent de saisir et de transcrire leurs observations sur le terrain étranger en fonction de leur intellect, de leur cognition et de leur expérience. Une série d’éléments marqués par l’altérité viennent modifier la représentation que l’auteur-voyageur donne du référent et de l’univers référentiel auquel il est confronté. C’est à cette façon « réductrice » de voir les référents issus d’un univers différent et à l’intervention de la subjectivité de l’auteur que nous nous intéressons dans cette étude. Nous analysons les effets discursifs produits par l’usage des ressources linguistiques ainsi que par les positionnements énonciatifs des auteurs-voyageurs. Cette approche homogénéisante et généralisante de la perception de l’Autre se fait au travers des moules préconstruits et une démarche subjective dans la culture réceptrice que nous tenterons de voir à l’aide des outils d’analyse langagiers et discursifs dans les récits de voyage de Goupil Fesquet (1844, de Rémy Aucher-Eloy (1843 et de J.M. Tancoigne (1819 en Orient, notamment en Perse.

  20. Common reference intervals for aspartate aminotransferase (AST), alanine aminotransferase (ALT) and γ-glutamyl transferase (GGT) in serum: results from an IFCC multicenter study.

    Science.gov (United States)

    Ceriotti, Ferruccio; Henny, Joseph; Queraltó, Josep; Ziyu, Shen; Özarda, Yeşim; Chen, Baorong; Boyd, James C; Panteghini, Mauro

    2010-11-01

    Aspartate aminotransferase (AST), alanine aminotransferase (ALT) and γ-glutamyl transferase (GGT) measurements are important for the assessment of liver damage. The aim of this study was to define the reference intervals (RIs) for these enzymes in adults, paying attention to standardization of the methods used and careful selection of the reference population. AST, ALT and GGT were measured with commercial analytical systems standardized to the IFCC-recommended reference measurement systems. Three centers (two in Italy and one in China) measured their own freshly collected samples; one of these centers also measured frozen samples from the Nordic Countries RI Project and from a Turkish center. RIs were generated using non-parametric techniques from the results of 765 individuals (411 females and 354 males, 18-85 years old) selected on the basis of the results of other laboratory tests and a specific questionnaire. AST results from the four regions (Milan, Beijing, Bursa and Nordic Countries) were statistically different, but these differences were too small to be clinically relevant. Likewise, differences between the upper reference limits for genders was only 1.7 U/L (0.03 μkat/L), allowing a single RI of 11-34 U/L (0.18-0.57 μkat/L) to be defined. Interregional differences were not statistically significant for ALT, but partitioning was required due to significant gender differences. RIs for ALT were 8-41 U/L (0.13-0.68 μkat/L) for females and 9-59 U/L (0.15-0.99 μkat/L) for males, respectively. The upper reference limits for GGT from the Nordic Country population were higher than those from the other three regions and results from this group were excluded from final calculations. The GGT RIs were 6-40 U/L (0.11-0.66 μkat/L) for females and 12-68 U/L (0.20- 1.13 μkat/L) for males, respectively. For AST and ALT, the implementation of common RIs appears to be possible, because no differences between regions were observed. However, a common RI for GGT that is

  1. Alternagin-C (ALT-C), a Disintegrin-Like Cys-Rich Protein Isolated from the Venom of the Snake Rhinocerophis alternatus, Stimulates Angiogenesis and Antioxidant Defenses in the Liver of Freshwater Fish, Hoplias malabaricus.

    Science.gov (United States)

    Monteiro, Diana Amaral; Selistre-de-Araújo, Heloisa Sobreiro; Tavares, Driele; Fernandes, Marisa Narciso; Kalinin, Ana Lúcia; Rantin, Francisco Tadeu

    2017-09-28

    Alternagin-C (ALT-C) is a disintegrin-like protein isolated from Rhinocerophis alternatus snake venom, which induces endothelial cell proliferation and angiogenesis. The aim of this study was to evaluate the systemic effects of a single dose of alternagin-C (0.5 mg·kg -1 , via intra-arterial) on oxidative stress biomarkers, histological alterations, vascular endothelial growth factor (VEGF) production, and the degree of vascularization in the liver of the freshwater fish traíra, Hoplias malabaricus , seven days after the initiation of therapy. ALT-C treatment increased VEGF levels and hepatic angiogenesis. ALT-C also enhanced hepatic antioxidant enzymes activities such as superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase, decreasing the basal oxidative damage to lipids and proteins in the fish liver. These results indicate that ALT-C improved hepatic tissue and may play a crucial role in tissue regeneration mechanisms.

  2. [Lange, Thomas. Zwischen Reformation und Untergang Alt-Livlands. Der Rigaer Erzbischof Wilhelm von Brandenburg im Beziehungsgeflecht der livländischen Konföderation und ihrer Nachbarländer] / Madis Maasing

    Index Scriptorium Estoniae

    Maasing, Madis, 1984-

    2014-01-01

    Arvustus: Lange, Thomas. Zwischen Reformation und Untergang Alt-Livlands. Der Rigaer Erzbischof Wilhelm von Brandenburg im Beziehungsgeflecht der livländischen Konföderation und ihrer Nachbarländer

  3. Synthesis and Properties of the Metallo-Supramolecular Polymer Hydrogel Poly[methyl vinyl ether-alt-mono-sodium maleate]∙AgNO3

    KAUST Repository

    Al-Dossary, Mona S.

    2014-05-01

    Gels are a special class of materials which are composed of 3D networks of crosslinked polymer chains that encapsulate liquid/air in the matrix. They can be classified into organogels or hydrogels (organic solvent for organogel and water for hydrogel). For hydrogels that contain metallic elements in the form of ions, the term of metallo-supramolecular polymer hydrogel (MSPHG) is often used. The aim of this project is to develop a kind of new MSPHG and investigate its properties and possible applications. The commercial polymeric anhydride poly(methyl vinyl ether-alt-maleic anhydride) (PVM/MA) is converted by reaction with NaOH to give poly(methyl vinyl ether-alt-monosodium maleate) (PVM/Na-MA). By addition of AgNO3-solution, the formation of the silver(I) supramolecular polymer hydrogel poly[methyl vinyl ether-alt-mono-sodium maleate]∙AgNO3 is obtained. Freeze-dried samples of the hydrogel show a mesoporous network of polycarboxylate ligands that are crosslinked by silver(I) cations. The supercritical CO2 dried silver(I) hydrogel was characterized by FT-IR, SEM-EDAX, TEM, TGA and Physical adsorption (BET) measurements. The intact silver(I) hydrogel was characterized by cryo-SEM. In the intact hydrogel, ion-exchange studies are reported and it is shown that Ag+ ions can be exchanged by copper(II) cations without disintegration of the hydrogel. The silver(I) hydrogel shows effective antibacterial activity and potential application as burn wound dressing.

  4. Dinámica del virus de la hepatitis C con carga viral y ALT y monitoreo del daño hepático libre de biopsias Dinámica del virus de la hepatitis C con carga viral y ALT y monitoreo del daño hepático libre de biopsias

    Directory of Open Access Journals (Sweden)

    Justino Alavez Domínguez

    2006-12-01

    Full Text Available Se compara el modelo estándar reducido de tres poblaciones (hepatocitos sanos y enfermos, y carga viral para el estudio de la dinámica del virus de la hepatitis C (VHC, con el modelo de la dinámica viral con alanina aminotransferasa (ALT. En términos del parámetro umbral que es el mismo para ambos modelos, se determina la existencia y estabilidad del estado de equilibrio endémico, así como la estabilidad global del estado de equilibrio del individuo sano. Por otro lado, se presenta un estudio experimental que muestra que es posible monitorear el daño hepático sin biopsias, mediante la estimación numérica de los parámetros de los modelos, considerando solamente mediciones de la carga viral, de los niveles de ALT y una valoración razonable del daño hepático pretratamiento.aThe standard model of three populations (healthy and unhealthy hepatocytes, and viral load for the study of the dynamics of hepatitis C virus (HCV, is compared with viral dynamic model with alanine aminotransferase (ALT. In terms of the threshold parameter that it’s the same for both models, the existence and local asymptotic stability of the endemically infected equilibrium steady state, and the global stability of the healthy individual equilibrium steady state are established. Furthermore, an experimental study is presented showing that it’s possible to carry out the monitoring of hepatic damage biopsies free by numerical parameter estimation, considering only viral load and ALT levels measurements and a reasonable assessment of pretreatment hepatic damage.

  5. Synthesis of electro-optically active polymer composite of poly[2,2'-bis(3,4-ethylenedioxythiophene-alt-fluorene]/hydroxypropyl cellulose showing liquid crystal structure

    Directory of Open Access Journals (Sweden)

    N. Eguchi

    2017-10-01

    Full Text Available Electrochemical preparation of a composite consisting of poly[2,2′-bis(3,4-ethylenedioxythiophene-alt-fluorene] and hydroxypropyl cellulose (PEFE/HPC was carried out. We conducted electrochemical polymerization of poly[2,2′-bis(3,4-ethylenedioxythiophene-alt-fluorene] (EFE as a monomer in a lyotropic liquid crystal of HPC. We used an organic solvent instead of water for lyotropic liquid crystal medium to expand the possibility of the range of monomers, although water is usually employed as a solvent for HPC for showing liquid crystallinity. Here, we employed N,N-dimethylformamide (DMF as a solvent for HPC. Electrochemical polymerization in the polymer liquid crystal was carried out to obtain a polymer film with liquid crystal order. The polymer film thus prepared exhibited optical activity. Fourier transfer infrared (FT-IR absorption spectroscopy reveals that the film is a composite consisting of HPC and polymer. The composite PEFE/HPC thus prepared in HPC/DMF system showed electrochromism.

  6. Influence of the composition of hydroxypropyl cellulose/maleic acid-alt-styrene copolymer blends on their properties as matrix for drug release

    Directory of Open Access Journals (Sweden)

    2009-05-01

    Full Text Available Poly(carboxylic acid-polysaccharide compositions have been found suitable for obtaining drug formulations with controlled release, most formulations being therapeutically efficacious, stable, and non-irritant. The influence of the characteristics of the aqueous solutions from which the polymer matrix is prepared (i.e. the total concentration of polymer in solutions and the mixing ratio between the partners, hydroxypropyl cellulose, HPC and maleic acid-alternating-styrene copolymer, MAc-alt-S on the kinetics of some drugs release in acidic environment (pH = 2 has been followed by ‘in vitro’ dissolution tests. It has been established that the kinetics of procaine hydrochloride release from HPC/MAc-alt-S matrix depends on its composition; the diffusion exponent, n is close to 0.5 for matrices where one of the components is in large excess and n~0.02 for middle composition range. The lower value of diffusion exponent for middle composition range could be caused by the so called ‘burst effect’, therefore the kinetic evaluation is difficult.

  7. Phase 1 trial of ALT-801, an interleukin-2/T cell receptor fusion protein targeting p53 (aa264-272)/HLA-A*0201 complex, in patients with advanced malignancies

    Science.gov (United States)

    Fishman, Mayer N.; Thompson, John A.; Pennock, Gregory K.; Gonzalez, Rene; Diez, Luz M.; Daud, Adil I.; Weber, Jeffery S.; Huang, Bee Y.; Tang, Shamay; Rhode, Peter R.; Wong, Hing C.

    2014-01-01

    Purpose ALT-801 is a bifunctional fusion protein comprising interleukin-2 (IL-2) linked to a soluble, single-chain T cell receptor domain that recognizes a peptide epitope (aa264-272) of the human p53 antigen displayed on cancer cells in the context of HLA-A*0201 (p53+/HLA-A*0201). We evaluated the safety, pharmacokinetics and pharmacodynamics of ALT-801 in p53+/HLA-A*0201 patients with metastatic malignancies. Experimental Design p53+/HLA-A*0201 patients were treated with ALT-801 on a schedule of 4 daily 15-minute intravenous infusions, then 10 days rest and 4 more daily infusions. Cohorts of patients were treated at 0.015, 0.040, and 0.080 mg/kg/dose. Results Four, sixteen, and six patients were treated at the 0.015, 0.04 and 0.08 mg/kg cohorts, respectively. Two dose limiting toxicities (a grade 4 transient thrombocytopenia and a myocardial infarction) in the 0.08 mg/kg cohort established the maximum tolerated dose (MTD) at 0.04 mg/kg. Patients treated at the MTD experienced toxicities similar to those associated with high-dose IL-2 but of lesser severity. The serum half-life of ALT-801 was 4 hours and ALT-801 serum recovery was as expected based on the dose administered. ALT-801 treatment induced an increase of serum interferon-γ but not tumor necrosis factor-α. Response assessment showed 10 subjects with stable disease at at least 11 weeks, and in one who had melanoma metastasis, there is an ongoing complete absence of identifiable disease after resection of radiographically identified lesions. Conclusion This first-in-man study defines an ALT-801 regimen that can be administered safely and is associated with immunological changes of potential antitumor relevance. PMID:21994418

  8. Activity of Catalase (CAT, ALT and AST in Different Organs of Swiss Albino Mice Treated with Lead Acetate, Vitamin C and Magnesium-L-Threonate

    Directory of Open Access Journals (Sweden)

    Ilir Nazmi Mazreku

    2017-11-01

    Full Text Available Introduction: Lead is a natural element with toxic properties and is widespread in the environment. Lead toxicity is associated with generation of reactive oxygen and nitrogen species and consumption of antioxidants elements (vitamin E and C, glutathione, thioredoxin and lipoic acid, melatonin, carotenoids and natural flavonoids in the cell, and unbalancing oxidantsantioxidants levels. Aim: To evaluate the effects of different chemical combinations (lead acetate, Vitamin C and Magnesium-L-threonate on antioxidant enzyme activity (catalase-CAT of liver, kidney, spleen, pancreas and brain, and serum transaminases [Serum Alanine Transaminase (ALT and Serum Aspartate Transaminase (AST]. Materials and Methods: Experimental animals (49 male Mus musculus-swiss albino mice were separated into five different groups. The first group was used as a control, hence the other four groups were treated with sub-lethal doses (90 mg/kg of lead acetate (group 2, lead acetate (90 mg/kg and Vitamin C dose 40mg/kg (group 3, lead acetate (90 mg/kg and Magnesium-Lthreonate dose 100 mg/kg (group 4 and only with MagnesiumL-threonate dose 100 mg/kg (group 5, during the treatment period (40 days. Blood samples were taken from the facial vein and used for transaminase analysis. Organ tissue was collected after euthanizing anaesthetized animals with neck dislocation technique. Results: The results showed that lead acetate treatment has caused significant elevation in the activity of AST (group 2 and 3 and ALT (group 3. Also, CAT activity was significantly (p<0.05 increased in groups treated with lead acetate (liver, pancreas, kidney and brain but not in spleen. Treatment of lead intoxicated groups with Vitamin C and Magnesium L-threonate increased significantly CAT activity in brain. Conclusion: Lead effects by interacting with different molecular systems and increasing enzyme activity (CAT, ALT and AST. Effects on CAT activity of Magnesium-L-threonate and Vitamin C treatment

  9. Treatment of skeletal class III malocclusion using face mask therapy with alternate rapid maxillary expansion and constriction (Alt-RAMEC protocol

    Directory of Open Access Journals (Sweden)

    Anand Ramchandra Rathi

    2015-01-01

    Full Text Available Class III malocclusion is very common malocclusion and can be due to maxillary retrusion, mandibular prognathism, or combination. Ellis and McNamara found a combination of maxillary retrusion and mandibular protrusion to be the most common skeletal relationship (30%. The treatment should be carried out as early as possible for permitting normal growth of the skeletal bases. Reverse pull head gear combined with maxillary expansion can effectively correct skeletal Class III malocclusion due to maxillary deficiency in growing patient. An eight-year-old female patient with chief complaint of prognathic mandible and anterior crossbite was successfully treated in duration of 5 months with facemask and expansion therapy based on Alternate Rapid Maxillary Expansion and Constriction (Alt-RAMEC protocol.

  10. Prognostic value of pretreatment serum alanine aminotransferase/aspartate aminotransferase (ALT/AST) ratio and gamma glutamyltransferase (GGT) in patients with esophageal squamous cell carcinoma.

    Science.gov (United States)

    Huang, Hao; Wang, Xue-Ping; Li, Xiao-Hui; Chen, Hao; Zheng, Xin; Lin, Jian-Hua; Kang, Ting; Zhang, Lin; Chen, Pei-Song

    2017-08-14

    The levels of liver function tests (LFTs) are often used to assess liver injury and non-liver disease-related mortality. In our study, the relationship between pretreatment serum LFTs and overall survival (OS) was evaluated in esophageal squamous cell carcinoma (ESCC) patients. Our purpose was to investigate the prognostic value of the preoperative alanine aminotransferase/aspartate aminotransferase (ALT/AST) ratio and gamma glutamyltransferase (GGT) in ESCC patients. A retrospective study was performed in 447 patients with ESCC, and follow-up period was at least 60 months until death. The prognostic significance of serum LFTs were determined by univariate and multivariate Cox hazard models. LFTs including ALT, AST, LSR, GGT, TBA and LDH were analyzed. Serum LSR (HR: 0.592, 95% CI = 0.457-0.768, p < 0.001 and GGT (HR: 1.507, 95% CI = 1.163-1.953, p = 0.002) levels were indicated as significant predictors of OS. The 5-year OS among patients with higher LSR levels was longer compared with those patients with decreased LSR levels, not only in the whole cohort but also in the subgroups stratified by pathological stage (T1-T2 subgroup, T3-T4 subgroup, N0 subgroup and M0 subgroup). We also found that patients with a higher GGT might predict worse OS than patients with a normal GGT, not only in the whole cohort but also in the subgroups stratified by pathological stage (T3-T4 subgroup and N1-N2 subgroup). Both increased levels of LSR and decreased levels of GGT might predict shorter overall survival in ESCC patients. Our findings suggest that serum LSR and GGT levels could be used as a key predictor of survival in patients with ESCC.

  11. [Value of non-invasive models of liver fibrosis in judgment of treatment timing in chronic hepatitis B patients with ALT < 2×upper limit of normal].

    Science.gov (United States)

    Zhou, Q Q; Hu, Y B; Zhou, K; Zhang, W W; Li, M H; Dong, P; Di, J G; Hong, L; Du, Q W; Xie, Y; Sun, Q F

    2016-09-20

    Objective: To investigate the value of non-invasive liver fibrosis models, FIB-4, S index, aspartate aminotransferase to platelet ratio index(APRI), globulin-platelet(GP)model, aspartate aminotransferase/platelet/gamma-glutamyl transpeptidase/alpha-fetoprotein(APGA), and platelet/age/phosphatase/alpha-fetoprotein/aspartate aminotransferase(PAPAS), in the diagnosis of marked liver fibrosis in chronic hepatitis B(CHB)patients with ALT liver biopsy was performed to obtain pathological results, and routine serological tests were performed, including routine blood test, serum biochemical parameters, hepatitis B virus(HBV)markers, and HBV DNA. According to liver pathology, the patients were divided into non-marked liver fibrosis group(S liver fibrosis group(S≥2)with 65 patients. The non-invasive models for predicting liver fibrosis was established with reference to original articles. SPSS 19.0 software was used for statistical analysis, and the receiver operating characteristic(ROC)curve was used to compare the value of different non-invasive models in predicting marked liver fibrosis in this population. Results: All the non-invasive models had a certain diagnostic value for liver fibrosis degree in these patients, and the areas under the ROC curve for APRI, FIB-4, APGA, S index, PAPAS, and GP model were 0.718, 0.691, 0.758, 0.729, 0.673, and 0.691, respectively. APGA had the largest area under the ROC curve(0.758, 95% CI 0.673-0.844), and gamma-glutamyl transpeptidase was significantly positively correlated with liver fibrosis degree. Conclusion: The non-invasive models of liver fibrosis can identify marked liver fibrosis in CHB patients with ALT liver biopsy to the certain degree.

  12. Synthesis and properties of the metallo-supramolecular polymer hydrogel poly[methyl vinyl ether-alt-mono-sodium maleate]·AgNO3: Ag+/Cu2+ ion exchange and effective antibacterial activity

    KAUST Repository

    Xu, Feng

    2014-01-01

    The commercial polymeric anhydride poly(methyl vinyl ether-alt-maleic anhydride) (PVM/MA) is converted by reaction with NaOH to give poly(methyl vinyl ether-alt-mono-sodium maleate) (PVM/Na-MA). By addition of AgNO 3-solution, the formation of the silver(i) supramolecular polymer hydrogel poly[methyl vinyl ether-alt-mono-sodium maleate]·AgNO 3 is reported. Freeze-dried samples of the hydrogel show a mesoporous network of polycarboxylate ligands that are crosslinked by silver(i) cations. In the intact hydrogel, ion-exchange studies are reported and it is shown that Ag+ ions can be exchanged by copper(ii) cations without disintegration of the hydrogel. The silver(i) hydrogel shows effective antibacterial activity and potential application as burn wound dressing. © the Partner Organisations 2014.

  13. Academic learning time in physical education (ALT-PE: is it related to fundamental movement skill acquisition and learning?. Tiempo de aprendizaje académico en educación física (ALT-PE: ¿tiene que ver con la adquisición y aprendizaje de habilidades motrices fundamentales?

    Directory of Open Access Journals (Sweden)

    Loza Olave, Edmundo

    2007-01-01

    Full Text Available AbstractIn this study, the relationship between time-variables of the physical education lesson and fundamental movement skill acquisition and learning was examined. One hundred and ten first grade students and their six physical educators participated. Students were pre-, post-, and re-tested both qualitatively and quantitatively on overhand throwing and catching. The Test of Gross Motor Development (Ulrich, 1985 was used for the assessment of qualitative skill performance and the Michigan Educational Assessment Program (MEAP, 1984 for the assessment of quantitative skill performance. Between pre- and post-tests students received an eight lessons unit instruction with emphasis on overhand throwing and catching. A total number of thirty-six students (6 students X 6 schools were selected, andtheir videotaped motor behavior in the lessons was analyzed with the Academic Learning Time ¿ Physical Education (ALT-PE,Parker, 1989. Regression analysis was applied to calculate students´ residual scores of achievement and to enable further data analysis. Correlation analysis between students´ achievement and ALT-PE categories indicated significant relationships between skill acquisition, learning and ALT-PE categories. It can be concluded that time devoted to practice skills, unlike times pent on activities irrelevant to the instructional task oron games, contributes to skill learning.ResumenEn este trabajo se estudia la relación entre variables temporales de las clases de Educación Física y la adquisición y aprendizaje de habilidades motrices fundamentales. En él participaron ciento diez alumnos de primer grado y seis profesores de Educación Física de Grecia. Los alumnos fueron examinados antes, durante y después tanto en términos cuantitativos como cualitativos en cuanto a lanzamientos y recepciones por encima de la cabeza. Se utilizó el Test de Desarrollo Motor Grueso (Ulrich, 1985 para evaluar el rendimiento en habilidades cualitativas y

  14. Los visitantes del Parc Natural de l’Alt Pirineu y la práctica de actividades recreativo-deportivas. una propuesta de segmentación

    Directory of Open Access Journals (Sweden)

    Farías, E. I.

    2014-12-01

    Full Text Available In recent years there has been a large increase in the practice of recreational and sports activities in protected natural areas. As part of the planning and management of public use of these areas, is essential to a deeper understanding of the characteristics of the visitors. This study analyzes the characteristics of the different segments of visitors to Alt Pirineu Natural Park based on recreational and sports activities practiced. For this study, 1.600 surveys were conducted in 16 sampling points over a calendar year between the months of July 2010 and June 2011. In total we identified eight segments of visitors based on physical activity: walkers, recreational hikers, hikers, mountaineer, cyclists, mushroom picker, off road driver and skier. The results obtained here are discussed in terms of their possible applicability in the management of public use of this park and other protected natural areas and also for the development of management strategies and awareness campaigns aimed at different segments of visitors.En los últimos años se ha registrado un gran incremento en la práctica de las actividades recreativodeportivas en los espacios naturales protegidos. En el marco de la planificación y la gestión del uso público de este tipo de espacios, resulta fundamental profundizar en el conocimiento de las características de los visitantes. En este estudio se analiza el perfil de los diferentes segmentos de visitantes del Parc Natural de l’Alt Pirineu en base a las actividades recreativo-deportivas practicadas. Para este estudio se realizaron 1.600 encuestas en 16 puntos de muestreo, a lo largo de un año natural comprendido entre los meses de Julio de 2010 y Junio de 2011. En total se identificaron ocho segmentos de visitantes en función de la actividad física: paseantes, excursionistas, senderistas, montañistas, ciclistas, recolectores de setas, motoristas y esquiadores. Los resultados aquí obtenidos son discutidos en t

  15. Changes of serum levels of prealbumin (PAB), cholinesterase (CHE), total bile acid (TBA) and ALT as related to the severity of inflammatory process and hepatic fibrosis in patients with chronic virus B hepatitis

    International Nuclear Information System (INIS)

    Chi Xiaoxia; Chen Jianxiong; Xiong Ying

    2005-01-01

    Objective: To study the correlationship between the serum levels of PAB, CHE, TBA, ALT and the severity of the disease process in patients with chronic virus B hepatitis. Methods: Serum levels of PAB, CHE, ALT (with biochemical methods) and TBA (with RIA) were examined in 93 patients with biopsy proven virus B hepatitis and 46 controls. Results: The 93 patients were of two groups: a less advanced group (n=51) and a more advanced group (n=42). Serum TBA, ALT levels were significnatly higher and serum PAB, CHE levels were significantly lower in the more advanced group than those in the less advanced group (P 0 to s 4 . Changes of levels of ALT were of no regular pattern, but serum levels of TBA regularly increased and levels of PAB, CHE regularly decreased as the fibrosis grading proceeded from s 0 to s 4 and the differences between the levels in s 4 and any other grading were significant (P<0.01). Conclusion: Combined determination of these serum markers might reflect the degree of inflammatory process and hepatic fibrosis in patients with virus B hepatitis, leading to earlier detection of cirrhosis. (authors)

  16. [Thomas Lange. Zwischen Reformation und Untergang Alt-Livlands : der Rigaer Erzbischof Wilhelm von Brandenburg im Beziehungsgeflecht der livländischen Konföderation und ihrer Nachbarländer] / Juhan Kreem

    Index Scriptorium Estoniae

    Kreem, Juhan, 1971-

    2015-01-01

    Arvustus: Lange, Thomas. Zwischen Reformation und Untergang Alt-Livlands : der Rigaer Erzbischof Wilhelm von Brandenburg im Beziehungsgeflecht der livländischen Konföderation und ihrer Nachbarländer (Hamburger Beiträge zur Geschichte des östlichen Europa)

  17. Els lepidòpters de la vall d’Alinyà (Alt Urgell, NE de la península Ibèrica: algunes consideracions sobre l’altitud i la classificació biogeogràfica

    Directory of Open Access Journals (Sweden)

    Vallhonrat, F.

    2005-12-01

    Full Text Available The Lepidoptera of the Alinyà valley (Alt Urgell, NE Iberian peninsula: some remarks about altitude and biogeographical classification Results from the census on Lepidoptera fauna carried out in Alinyà valley during years 2000 and 2001 (see annex show few significant differences in the altitudinal range between Mediterranean and Eurasiatic species.

  18. Multifunctional e-spun colloidal nanofiber structures from various dispersed blends of PVA/ODA-MMT with PVP/ODA-MMT, poly(VP-alt-MA and AgNPs incorporated polymer complexes as electro-active platforms

    Directory of Open Access Journals (Sweden)

    U. Bunyatova

    2016-07-01

    Full Text Available This work presented a new approach to fabricate polymer nanocomposites films with nanofiber structures from solution blends of poly(vinyl alcohol + octadecyl amine-montmorillonite (ODA-MMT (matrix with poly(N-vinylpyrrolidone + ODA-MMT (partner-1, poly(N-vinylpyrrolidone-alt-maleic anhydride ((poly(VP-alt-MA + (ODA-MMT (partner-2 and their silver (Ag-carrying polymer complexes by electrospinning. Chemical and physical structures, surface morphologies, thermal behaviors, electrical conductivity and thermal resistance parameters of nanofiber structures were investigated. Poly(VP-alt-MA was used both as a crosslinker and a donor of the hydrophilic groups such as ‒COOH and ‒NH–C=O amide from pyrrolidone ring. Reactive poly(VP-alt-MA, in situ generated Ag nanoparticles (AgNPs and original partner polymer had an significant effect on the morphology and diameter distribution of nanofibers. High and excellent conductive behaviors were observed for the homopolymer and copolymer of VP based fiber structures, respectively. Upon successive chemical cross-linking of the nanofiber structures by reactive partner copolymer, the conductivity of nanofiber films as electro-active platforms dramatically increased to 3.90·10–2 S·cm–1 at room temperature. Comparative analysis results also indicated that electrical properties strongly depended on the loaded reactive organoclay and in situ generated AgNPs.

  19. Alt und Alt gleich Neu / Peter J. Strehmel

    Index Scriptorium Estoniae

    Strehmel, Peter J.

    1994-01-01

    Hortus Musicus - Andres Mustonen: Himmel / Earth / Heaven / Erde: 1200-1600, Medieval Renaissance (CD I "Instrumental Music", CD II "Vocal Music"). Erdenklang 40692-1+2; Hortus Musicus - Andres Mustonen: Himmel / Earth / Heaven / Erde: Gregorianische Chorale, Plainchants. Erdenklang 40712

  20. A study on the morphology of polystyrene-grafted poly(ethylene-alt-tetrafluoroethylene) (ETFE) films prepared using a simultaneous radiation grafting method

    International Nuclear Information System (INIS)

    Song, Ju-Myung; Ko, Beom-Seok; Sohn, Joon-Yong; Nho, Young Chang; Shin, Junhwa

    2014-01-01

    The morphology of polystyrene-grafted poly(ethylene-alt-tetrafluoroethylene) (ETFE) films prepared using a simultaneous radiation grafting method was investigated using DMA, DSC, XRD, and SAXS instruments. The DMA study indicates that the ETFE amorphous phase and PS amorphous phase are mixed well in the PS-grafted ETFE films while the ETFE crystalline phase and the PS amorphous phase are separated, suggesting that the PS chains are grafted mainly on the ETFE amorphous regions. The DSC and XRD data showed that the natural crystalline structures of ETFE in the grafted ETFE films are not affected by the degree of grafting. The SAXS profiles displayed that the inter-crystalline distance of the ETFE films increases with an increasing degree of grafting, which further implies that the PS graft chains formed by the simultaneous irradiation has a significant impact on the amorphous morphology of the resulting grafted ETFE film. Thus, these results indicate that the styrene monomers are mainly grafted on the ETFE amorphous regions during the simultaneous radiation grafting process. - Highlights: • PS-grafted ETFE films were prepared by a simultaneous radiation grafting method was investigated. • The natural crystalline structures of grafted ETFE films are not affect by the degree of grafting. • The inter-crystalline distance of the ETFE films increase with increasing degree of grafting. • The styrene monomers are mainly grafted on the ETFE amorphous regions during a simultaneous radiation grafting using gamma-ray

  1. Post-irradiation time effects on the graft of poly(ethylene-alt-tetrafluoroethylene) (ETFE) films for ion exchange membrane application

    Energy Technology Data Exchange (ETDEWEB)

    Geraldes, Adriana N., E-mail: angeral@ipen.b [Instituto de Pesquisas Energeticas e Nucleares (IPEN), Centro de Quimica e Meio Ambiente (CQMA), Av. Professor Lineu Prestes, 2242, 05508-900, Sao Paulo (Brazil); Zen, Heloisa A.; Ribeiro, Geise; Ferreira, Henrique P.; Souza, Camila P.; Parra, Duclerc F.; Santiago, Elisabete I.; Lugao, Ademar B. [Instituto de Pesquisas Energeticas e Nucleares (IPEN), Centro de Quimica e Meio Ambiente (CQMA), Av. Professor Lineu Prestes, 2242, 05508-900, Sao Paulo (Brazil)

    2010-03-15

    Grafting of styrene followed by sulfonation onto poly(ethylene-alt-tetrafluoroethylene) (ETFE) was studied for synthesis of ion exchange membranes. Radiation-induced grafting of styrene onto ETFE films was investigated after simultaneous irradiation (in post-irradiation condition) using a {sup 60}Co source. The ETFE films were irradiated at 20 kGy dose at room temperature and chemical changes were monitored after contact with styrene for grafting. The post-irradiation time was established at 14 days when the films were remained in styrene/toluene 1:1 v/v. After this period the grafting degree was evaluated in the samples. The grafted films were sulfonated using chlorosulfonic acid and 1, 2-dichloroethane 20:80 (v/v) at room temperature for 5 h. The membranes were analyzed by infrared spectroscopy (FTIR), differential scanning calorimeter (DSC), thermogravimetric measurements (TG) and degree of grafting (DOG). The ion exchange capacity (IEC) of membranes was determined by acid-base titration and the values for ETFE membranes were achieved higher than Nafion films. Preliminary single cell performance was made using pure H{sub 2} and O{sub 2} as reactants at a cell temperature of 80 deg. C and atmospheric gas pressure. The fuel cell performance of ETFE films was satisfactory when compared to state-of-art Nafion membranes.

  2. Post-irradiation time effects on the graft of poly(ethylene-alt-tetrafluoroethylene) (ETFE) films for ion exchange membrane application

    Science.gov (United States)

    Geraldes, Adriana N.; Zen, Heloísa A.; Ribeiro, Geise; Ferreira, Henrique P.; Souza, Camila P.; Parra, Duclerc F.; Santiago, Elisabete I.; Lugão, Ademar B.

    2010-03-01

    Grafting of styrene followed by sulfonation onto poly(ethylene-alt-tetrafluoroethylene) (ETFE) was studied for synthesis of ion exchange membranes. Radiation-induced grafting of styrene onto ETFE films was investigated after simultaneous irradiation (in post-irradiation condition) using a 60Co source. The ETFE films were irradiated at 20 kGy dose at room temperature and chemical changes were monitored after contact with styrene for grafting. The post-irradiation time was established at 14 days when the films were remained in styrene/toluene 1:1 v/v. After this period the grafting degree was evaluated in the samples. The grafted films were sulfonated using chlorosulfonic acid and 1, 2-dichloroethane 20:80 (v/v) at room temperature for 5 h. The membranes were analyzed by infrared spectroscopy (FTIR), differential scanning calorimeter (DSC), thermogravimetric measurements (TG) and degree of grafting (DOG). The ion exchange capacity (IEC) of membranes was determined by acid-base titration and the values for ETFE membranes were achieved higher than Nafion ® films. Preliminary single cell performance was made using pure H 2 and O 2 as reactants at a cell temperature of 80 °C and atmospheric gas pressure. The fuel cell performance of ETFE films was satisfactory when compared to state-of-art Nafion ® membranes.

  3. Rhodium-Coordinated Poly(arylene-ethynylene)-alt-Poly(arylene-vinylene) Copolymer Acting as Photocatalyst for Visible-Light-Powered NAD+/NADH Reduction

    Science.gov (United States)

    2014-01-01

    A 2,2′-bipyridyl-containing poly(arylene-ethynylene)-alt-poly(arylene-vinylene) polymer, acting as a light-harvesting ligand system, was synthesized and coupled to an organometallic rhodium complex designed for photocatalytic NAD+/NADH reduction. The material, which absorbs over a wide spectral range, was characterized by using various analytical techniques, confirming its chemical structure and properties. The dielectric function of the material was determined from spectroscopic ellipsometry measurements. Photocatalytic reduction of nucleotide redox cofactors under visible light irradiation (390–650 nm) was performed and is discussed in detail. The new metal-containing polymer can be used to cover large surface areas (e.g. glass beads) and, due to this immobilization step, can be easily separated from the reaction solution after photolysis. Because of its high stability, the polymer-based catalyst system can be repeatedly used under different reaction conditions for (photo)chemical reduction of NAD+. With this concept, enzymatic, photo-biocatalytic systems for solar energy conversion can be facilitated, and the precious metal catalyst can be recycled. PMID:25130570

  4. Alt-Az Spacewatch Telescope

    Science.gov (United States)

    Gehrels, Tom

    1997-01-01

    This grant funded about one third of the cost of the construction of a telescope with an aperture 1.8 meters in diameter to discover asteroids and comets and investigate the statistics of their populations and orbital distributions. This telescope has been built to the PI's specifications and installed in a dome on Kitt Peak mountain in Arizona. Funds for the dome and building were provided entirely by private sources. The dome building and telescope were dedicated in a ceremony at the site on June 7, 1997. The attached abstract describes the parameters of the telescope. The telescope is a new item of capital property. It is permanently located in University of Arizona building number 910 in the Steward Observatory compound on Kitt Peak mountain in the Tohono O'odham Nation, Arizona. fts property tag number is A252107. This grant did not include funds for the coma corrector lens, instrument derotator, CCD detector, detector electronics, or computers to acquire or process the data. It also did not include funds to operate the telescope or conduct research with it. Funds for these items and efforts are pending from NASA and other sources.

  5. Jung und Alt im Dialog

    Directory of Open Access Journals (Sweden)

    Caroline Baetge

    2012-04-01

    Full Text Available Rezension zu: Kupser, Thomas, und Ida Pöttinger, Hrsg. 2011. Mediale Brücken: Generationen im Dialog durch aktive Medienarbeit. Gesellschaft - Altern - Medien 3. München: kopaed.

  6. The Iberian hamlet of L’Alt del Punxó: agricultural production and peasant settlement in central Contestania | La aldea ibérica de L’Alt del Punxó: producción agrícola y asentamiento campesino en el área central de la Contestania

    Directory of Open Access Journals (Sweden)

    Israel Espí Pérez

    2009-12-01

    Full Text Available In this paper we describe an Iberian Iron Age village recently excavated as a result of the construction of a new motorway through Muro de l’Alcoi (El Comtat, Alicante province, Spain. The hamlet consists of huts, agricultural buildings and a paved road dating to between the seventh and fourth centuries BC. L’Alt del Punxó has significantly advanced our knowledge of Iberian settlement patterns and the organisation of economic activity in this area. An integrated analysis of the evidence furnished by the fieldwork increases our knowledge of different aspects of the social and economic organization of Iberian Iron Age populations in central Contestania. | En este trabajo damos a conocer un hábitat rural de época ibérica excavado con motivo de recientes obras de construcción de la Autovía del Mediterráneo a su paso por la localidad de Muro de l’Alcoi (El Comtat, Alacant. La aldea está conformada por cabañas, instalaciones de procesamiento agrícola y un camino empedrado que se datan entre los ss. VII y IV aC. L’Alt del Punxó ha permitido un considerable avance en el conocimiento de las formas de ocupación rural y articulación de la actividad económica de este territorio ibérico. La lectura integrada de la documentación permite abordar distintas cuestiones de la organización económica y social de los grupos ibéricos del área central de la Contestania.

  7. Altındere Vadisi Milli Parkı kullanıcılarının rekreasyonel memnuniyetinin belirlenmesi

    Directory of Open Access Journals (Sweden)

    Özge Volkan AKSU

    2017-07-01

    Full Text Available Bu çalışma; Altındere Vadisi Milli Parkı kullanıcılarının rekreasyonel memnuniyetinin belirlenmesi amacı ile 2015 yılı yaz dönemi milli park alanında, 308 yerli kullanıcı ile yapılan anket çalışmalarını kapsamaktadır. Anket soruları ile kullanıcılarının bazı kişisel özellikleri, kullanım tercihleri, katıldıkları rekreasyonel etkinlikler, geliş amaçları, alan tercihleri, genel ve beklenen memnuniyetleri, alan farkındalığı, kullanıcı memnuniyet ve memnuniyetsizlik durumunu etkileyen faktörler ve bu faktörlerle kullanıcıların bazı kişisel özellikleri arasındaki ilişkiler istatistiksel yöntemlerle irdelenmiştir. Sonuç olarak; “milli parkın doğal ve kültürel peyzaj değerleri, görsel kalite”, “alandan aktif olarak yararlanma isteği”, “alandan pasif olarak yararlanma isteği”, “macera ve kendini keşfetme”, “açık hava aktivite olanakları”, “sosyalleşme”,  “ulaşılabilirlik ve alan kullanımı” olarak tanımlanabilecek faktörlerin alandaki kullanıcı memnuniyeti üzerinde etkili olduğu, yine; “planlama-tasarım sorunları”, “donatı elemanı eksikliği, yönetim”, “taşıma kapasitesinin aşılması-kalabalık, gürültü kirliliği”, “çevre-görüntü kirliliği, alt yapı-bakım eksikliği”, “bilgi eksikliği ve yönetim” olarak tanımlanabilecek faktörlerin ise kullanıcı memnuniyetsizliği üzerinde etkili olduğu belirlenmiştir. Kullanıcıların genel memnuniyet ve beklentilerinin karşılanma durumu orta düzeydir. Kullanıcıların memnuniyet faktörlerinin, geldiği yerin milli parka uzaklığı ve eğitim, memnuniyetsizlik faktörlerinin ise geldiği yerin milli parka uzaklığı, cinsiyet ve yaş olarak belirlenen etmenlerden etkilendiği saptanmıştır.

  8. Deprem Yükleri Altında Kalıcı Şev Deplasmanlarının Tahmini

    Directory of Open Access Journals (Sweden)

    Deniz ÜLGEN

    2014-09-01

    Full Text Available Dinamik yükleme altındaki şevlerin stabilitesi genel olarak yarı-statik analiz yöntemi kullanılarak incelenir. Bu yöntem, belirli bir güvenlik katsayısını dikkate almakla birlikte, oluşan kalıcı deplasmanlar hakkında bir bilgi vermemektedir. Newmark, güçlü deprem hareketlerine maruz kalan şevlerin kalıcı deplasmanlarının tahmini için bir analiz yöntemi önermiştir. Bu çalışmada, saha şartları ve deprem özellikleri dikkate alınarak şevlerin davranışı dinamik analizlerle irdelenmiştir. Bu analizlerde, çeşitli gerçekçi şev modelleri seçilerek sonlu elemanlar yöntemi kullanılmıştır. İlk olarak, şevlerdeki potansiyel kayma yüzeyleri, basitleştirilmiş Bishop metoduyla belirlenmiştir. Daha sonra, kayma yüzeylerinin kritik ivmeleri ve maksimum ortalama etkin ivmeleri bulunarak, Newmark yöntemiyle şevlerin kalıcı deplasmanları hesaplanmıştır. Son olarak, deprem kaynaklı kalıcı şev deplasmanlarının ön tahmini için basit bir grafik ve formülasyon önerilmiştir

  9. Ways to live history. Or philosophy, culture, and architecture in the origins of the museum Altes in Berlín Formas de habitar la historia. O la filosofía, la cultura y la arquitectura en la fundación del Museo Altes de Berlín Modos de habitar a história ou Filosofia, cultura e arquitetura na fundação do Altes Museum de Berlim

    Directory of Open Access Journals (Sweden)

    Fabiano Lemos

    2011-01-01

    Full Text Available From the beginnings of what we now know as our modernity, man has been surprised with his own finitude. The 18th and 19th  century bourgeois needed to formulate complex ways of preserving the past and of linking with it. In the philosophes’ circle, time concept starts to double itself in the idea of origin, that, for them, had become opaque. We just need to think of the broad-range process of structuring museums and restructuring natural history collections in cities such as Paris and Berlin, around the turn to the 19th century, so that we can be convinced that the surprise with that origin that one cannot recognize anymore, that becomes object of popular and scientific interest, leads each and all of the decisions in this process. Museum is just one of the institutions in which man, through a complex series of idealizations of space, show himself the spectacle of a lost time and, thus, of a culture whose educational thrive can only be understood by associating to these institutions. Our task is to investigate – and the case study of the grounding of the Altes Museum in Berlin, between 1822 and 1830, will perform this concretely – which educational policy made the emergence of this new ideological model possible, and , on the opposite way, which conceptual elaborations confirmed or legitimated the new pragmatic topography of time in modernity within the institution that had as aim, precisely, articulate and administrate past and memory. Desde los albores de la modernidad tal como la entendemos hoy en día, el hombre se espanta por su finitud. El burgués de los siglos XVIII y XIX tuvo que crear mecanismos complejos para la preservación del pasado y su relación con él. En el círculo de philosophes, la noción del tiempo comienza a replicarse en la idea de origen, que para ellos se convirtió en opaca. Basta pensar en el amplio

  10. Synthesis and photophysical and electroluminescent properties of poly(1,4-phenylene–ethynylene)-alt-poly(1,4-phenylene–vinylene)s with various dissymmetric substitution of alkoxy side chains

    Czech Academy of Sciences Publication Activity Database

    Bouguerra, N.; Růžička, Aleš; Ulbricht, C.; Enengl, C.; Enengl, S.; Pokorná, Veronika; Výprachtický, Drahomír; Tordin, E.; Aitout, R.; Cimrová, Věra; Egbe, D. A. M.

    2016-01-01

    Roč. 49, č. 2 (2016), s. 455-464 ISSN 0024-9297 R&D Projects: GA ČR(CZ) GA13-26542S; GA ČR(CZ) GAP106/12/0827 Institutional support: RVO:61389013 Keywords : poly(1,4-phenylene-ethynylene)-alt-poly(1,4-phenylene-vinylene)s * dissymmetric side chains * synthesis Subject RIV: CD - Macromolecular Chemistry Impact factor: 5.835, year: 2016

  11. PARÁMETROS BIOQUÍMICOS ENZIMÁTICOS (ALT, AST, ALP, Γ-GT, LDH EN NIÑOS CON LEUCEMIA LINFOBLÁSTICA AGUDA ANTES DEL TRATAMIENTO ANTINEOPLÁSICO

    Directory of Open Access Journals (Sweden)

    Jeél Moya S

    2015-12-01

    Full Text Available Objective: To determine the enzymatic biochemical parameters (glutamic pyruvic transaminase (ALT, glutamic oxaloacetic transaminase (AST, alkaline phosphatase (ALP, gamma glutamyltransferase (γ-GT, and lactate dehydrogenase (LDH in children with acute lymphoblastic leukemia (ALL before cancer treatment. Material and Methods: A prospective experimental, observational, cross-sectional study was conducted in 30 children between 2 and 15 years old, from several Neoplastic Centers in Lima. Blood collection was performed in BD red cap Vacutainer tubes, processed in the semi-automated analyzer BIOTEC® EMP-168, with Wiener Lab Group enzyme reagents under the modified method Szaaz and UV-Optimized by IFCC, SSCC and SFBC. Finally, coding and tabulation was performed. Results: 60% were boys and 46.7% are between the ages of 2-6 years. Serum levels of AST were increased by 33.3% in boys and 50% in girls. Serum ALT values were increased in 33.3% of boys and 41.7% of girls; only 25% of girls showed increased levels of γ-GT values; ALP was increased in 44.4% of boys and 66.7% of girls. Moreover LDH levels were increased in 55.6% of boys and 41.7% of girls. Conclusions: The enzymatic tests LDH, AST, ALT and ALP are increased in children with ALL compared to normal values due to tumor lysis syndrome characterized by electrolyte abnormalities, and as a result of the massive destruction of tumor cells and rapid release of large amounts of intracellular elements.

  12. Novel poly(triphenylamine-alt-fluorene) with asymmetric hexaphenylbenzene and pyrene moieties: synthesis, fluorescence, flexible near-infrared electrochromic devices and theoretical investigation

    KAUST Repository

    Wang, Po-I.

    2016-01-13

    © The Royal Society of Chemistry 2016. In this study, a new triphenylamine-alt-fluorene conjugated copolymer, HPBPYFL6, with hexaphenylbenzene (HPB) and pyrene as asymmetrical pendant groups was synthesized via Suzuki coupling polymerization. The conjugated polymer had a weight-average molecular weight of 5.8 × 104 g mol-1 with a polydispersity index of 2.5 characterized by gel permeation chromatography (GPC). HPBPYFL6 showed good solubility in common organic solvents such as NMP, THF, toluene and dichloromethane at 25°C. In addition, HPBPYFL6 possessed a high glass transition temperature of 260°C and a 10% weight-loss temperature of 503°C in nitrogen. HPBPYFL6 bearing a pyrene moiety had a solvatochromic fluorescence shift from a green to an orange emission as the polarity of the solvent increased. Cyclic voltammetry of HPBPYFL6 films cast onto indium-tin oxide-coated glass (ITO-glass) exhibited two oxidation redox couples at an E1/2 value of 0.82 and 1.17 V versus Ag/Ag+ in an acetonitrile solution. The HPBPYFL6 film on graphene-coated PET had an E1/2 value of 0.24 and 1.12 V. Conjugated polymer films exhibited reversible electrochromic behaviour with a colour change from pale yellow to deep blue upon electrochemical oxidation and high absorbance in the near-infrared (NIR) region. The switching and bleaching times were 5.16 s and 3.12 s for 1231 nm and were 3.30 s and 3.74 s for 1030 nm of HPBPYFL6 on ITO-glass. The strong NIR electrochromic absorbance of HPBPYFL6 was attributed to intervalence charge transfer by the incorporation of the HPB moiety. This phenomenon was confirmed by chemical oxidation as the oxidant contents increased in the solution state. Furthermore, the electrochromic mechanism was interpreted by DFT calculation and the simulated NIR electrochromic spectra of model compound HPBPYFL are in good agreement with the experimental data.

  13. Resonance energy transfer from quinolinone modified polystyrene-block-poly(styrene-alt-maleic anhydride) copolymer to terbium(III) metal ions

    Energy Technology Data Exchange (ETDEWEB)

    Výprachtický, Drahomír, E-mail: vyprachticky@imc.cas.cz [Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovský Sq. 2, 162 06 Prague 6 (Czech Republic); Mikeš, František [New York University Polytechnic School of Engineering, Polymer Research Institute, 6 MetroTech Center, Brooklyn, NY 11201 (United States); Lokaj, Jan; Pokorná, Veronika; Cimrová, Věra [Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovský Sq. 2, 162 06 Prague 6 (Czech Republic)

    2015-04-15

    Polystyrene-block-poly(styrene-alt-maleic anhydride) was synthesized by nitroxide mediated radical polymerization and modified with 7-amino-4-methylquinolin-2(1H)-one (I) and methanol. The formed block polymer ligand contained a quinolinone fluorophore (Ω) and carboxyl (III) or sodium carboxylate (IV) binding sites. The ligand-to-metal resonance energy transfer (RET) and ligand binding properties of [III–Tb{sup 3+}] and [IV–Tb{sup 3+}] complexes were investigated by steady-state and time-resolved luminescence spectroscopy in tetrahydrofuran/methanol and/or tetrahydrofuran/deuterated methanol mixtures and compared with those of a low-molecular-weight model ligand, i.e. the sodium salt of N-(4-methyl-2-oxo-1,2-dihydroquinolin-7-yl)succinamic acid (II). The long-lived emission intensities of Tb{sup 3+} at 490, 545, 585, and 620 nm corresponding to the {sup 5}D{sub 4}→{sup 7}F{sub 6}, {sup 5}D{sub 4}→{sup 7}F{sub 5}, {sup 5}D{sub 4}→{sup 7}F{sub 4}, and {sup 5}D{sub 4}→{sup 7}F{sub 3} transitions, respectively, were strongly increased by the addition of ligands in the order [II-Tb{sup 3+}]⪡[III-Tb{sup 3+}]<[IV-Tb{sup 3+}]. The efficiency of energy transfer (E) was evaluated from the emission intensity of the donor (Ω) in the presence or absence of the acceptor (Tb{sup 3+}) depending on the acceptor concentration and ligand neutralization. It was concluded that the macromolecular ligand structural properties (polymer coil and supramolecular structures, e.g. micelles) were responsible for the increase in RET. The time-resolved luminescence measurements revealed that the binding affinity of the ligands II, III, and IV increased in the order II

  14. Üzüm Çekirdeği Tozu ve Peynir Altı Suyu Tozunun Tavuk Nugget Kalitesi Üzerine Etkileri

    Directory of Open Access Journals (Sweden)

    Ece Cagdas

    2015-02-01

    Full Text Available Bu çalışma kapsamında; buğday unu, mısır unu, tuz ve kabartma ajanı ile hazırlanan basit kaplama hamuruna değişik oranlarda üzüm çekirdeği tozu (GSP eklenerek kaplanan ve peynir altı suyu tozu çözeltisine (WPS daldırılarak kaplanan tavuk eti parçalarının ön kızartma işleminden sonra nem, protein, yağ ve yüzeyde yapışma miktarları belirlenmiştir. Bunların yanı sıra, doku, taramalı elektron mikroskobu (SEM ve tiyobarbitürik asit (TBA analizleri yapılmıştır. Yapılan çalışma sonucunda GSP miktarı arttıkça nem (%66.20±0.71 – 68.22±0.38, protein (%16.16±1.36 – 19.73±1.40 ve yüzeyde yapışma miktarı (%26.27±0.43 – 36.13±0.71 artış gösterirken yağ miktarında (%8.18±0.17 – 4.78±0.54 azalış meydana gelmiştir. En düşük yağ miktarları WPS’ye daldırılarak hazırlanan örneklerde bulunmuştur. Uygulama yapılan örneklerde ön kızartma işleminden sonra da antioksidan aktivite gözlenmiş ve uygulama yapılan tüm örneklerin TBA değerleri (23.30±1.61 – 27.17±1.12 mg MDA/kg kontrol ile karşılaştırıldığında daha düşük seviyelerde olsa da önemli bir fark belirlenmemiştir (P>0.05. Elde edilen sonuçlara göre kaplama harcı malzemesi olarak GSP kullanımı ve WPS’ye daldırma işlemi kaplama harcının kalitesinin geliştirilmesinde bir potansiyele sahiptir.

  15. New Fractures, Old Wounds: Africa and the Renewal of South Agency Neue Brüche, alte Wunden: Afrika und die Erneuerung der South agency

    Directory of Open Access Journals (Sweden)

    Carlos Lopes

    2010-01-01

    Afrikas – in all seiner Vielfalt zwischen subsaharischem Afrika, Maghreb und Ägypten – muss in diesem umfassenderen Kontext geführt werden. Die Erneuerung der South agency, die im vergangenen Jahrzehnt zu beobachten war, ist nicht gleichzusetzen mit der trilateralen Allianz Asien-Afrika-Lateinamerika in der Phase der Dekolonisation. Jüngste Megatrends signalisieren, dass der “globale Süden”, vorangetrieben von einigen Regionalmächten, bei der Gestaltung des 21. Jahrhunderts eine ganz wesentliche Rolle spielen wird. Ein Verständnis für die Komplexität dieser neuen Akteursrolle zu entwickeln, ist die Voraussetzung, wenn man alte Wunden ansprechen will, die in nicht allzu ferner Vergangenheit die Herausbildung einer Stimme des Südens begleiteten.

  16. Efeitos da farinha de folhas de mandioca sobre a atividade das enzimas AST, ALT, FA e lipídios hepáticos de ratos Wistar Effects of cassava leaves flour on the AST, ALT, ALP enzymes activity and hepatic lipids of Wistar rats

    Directory of Open Access Journals (Sweden)

    Daniela Séfora de Melo

    2008-12-01

    Full Text Available Folhas de mandioca possuem substâncias como ligninas e saponinas que podem apresentar efeito hipolipidêmico. Todavia, um estudo recente relatou aumento no peso do fígado de ratos alimentados com dietas contendo farinha de folhas de mandioca (FFM - Manihot esculenta Crantz cv. Cacao, tornando-se necessário um estudo mais aprofundado dos efeitos desta farinha sobre os parâmetros hepáticos. Para este estudo, um ensaio biológico com 32 ratos machos Wistar foi conduzido por um período de 7 semanas, sendo os tratamentos: dieta controle e dietas contendo 5, 10 e 15% de FFM. As dietas contendo FFM não apresentaram efeitos sobre as atividades das enzimas Aspartato Aminotransferase (AST e Fosfatase Alcalina (FA, mas aumentaram significativamente a atividade da enzima alanina aminotransferase (ALT. O estudo histopatológico revelou vacuolização do citoplasma dos hepatócitos para todos os grupos. No entanto, a freqüência de animais com vacuolização acentuada foi superior nos grupos que receberam dietas com FFM, apresentando também maiores teores de lipídios e colesterol total hepáticos e maior relação peso fígado/peso corporal. Estes resultados indicam que os antinutrientes presentes nas folhas de mandioca, como taninos, cianeto e saponinas, podem ser responsáveis pela redução da função hepática nos animais alimentados com FFM.Cassava leaves contain substances such as lignins and saponins that can present the hypolipidemic effect. However, a recent study has reported an increase in liver weight of rats fed diet containing cassava leaves flour (CLF - Manihot esculenta Crantz cv. Cacao. Thus, a further study of the effect of this flour on the hepatic parameters is necessary. For the development of this study, a biological assay with 32 male Wistar rats was conducted for a period of 7 weeks with the following treatments: control diet and diets containing 5, 10, and 15% of CLF. The diets containing CLF showed no effects on the

  17. Soil and Water Assessment Tool soil loss simulation at the sub-basin scale in the Alt Penedès-Anoia vineyard region (Ne Spain) in the 2000s

    OpenAIRE

    Martínez Casasnovas, José Antonio; Ramos Martín, Ma. C. (Ma. Concepción); Benites, Grace

    2016-01-01

    This paper evaluates soil loss due to water erosion in an area of 32,362 ha with a predominant land use of vineyards (Alt Penedès-Anoia region, Catalonia, Spain). The Soil and Water Assessment Tool (SWAT) was used incorporating daily climatic data for the period 2000-2010 and also detailed soil and land use maps. Particular attention was given to the universal soil loss equation cover and management factor (C factor) of vineyards, with a minimum value of 0·15 being determined for this crop. T...

  18. Avaliação hematológica e dosagem bioquímica de ALT, AST e creatinina em elefante-marinho-do-sul, Mirounga leonina (linnaeus, 1758, encontrado no litoral de Salvador, Bahia

    Directory of Open Access Journals (Sweden)

    Bruno Lopes Bastos

    2006-02-01

    Full Text Available Since 1999 the Aquatic Mammals Rescue Center - AMRC has been working in the rescue and rehabilitation of stranded cetaceans and pinnipeds on the coast of Bahia, Brazil. This paper presents and analyses the blood cells count and clinical chemistry of alanine aminotransferase (ALT, aspartate aminotransferase (AST and creatinine of a southern elephant seal, Mirounga leonina (LINNAEUS, 1758, found on February the 11th at Barra Beach, Salvador, BA. The specimen was an orphan male calf, with 137cm of length and estimated weight of 49kg. It presented bad nutritional conditions and a shark bite on the right shoulder area. Clinical management was performed for 56 days, anthelmintic Febendazole was utilized, and the bite was treated with iodined alcohol, Nitrofurazone solution and Kethanserin, simultaneously with Enrofloxacin 10%, Potenay®, Vitamin B Complex and Benerva®. On the 16th the animal presented a right unilateral conjuntivitis, treated with Cloranphenicol oftalmic pomade until the end of its stay in the captive. During this period a total of six blood samples were collected, three for total blood counts and the others for the biochemistry determination of ALT, AST and creatinine. According to the haematological analysis the seal developed an anaemia which was classified as microcytic and normochromic. Lymphopenia, eosinopenia and monocytopenia were also observed, possibly due to its handling and stress conditions. The clinical chemistry presented low values for AST and creatinine, although this did not represent the existence of any pathologic context or disease with clinical significance.

  19. Enhanced optophysical properties of poly[(9,9-di-n-octylfluorenyl-2,7-diyl)-alt-(benzo[2,1,3] thiadiazol-4,8-diyl)] via addition of TiO{sub 2} nanoparticles

    Energy Technology Data Exchange (ETDEWEB)

    Fuzi, Siti Aishah Ahmad, E-mail: aishah-fuzi@yahoo.com; Jumali, Mohammad Hafizuddin Hj, E-mail: hafizhj@ukm.edu.my; Al-Asbahi, Bandar Ali Abdulqader, E-mail: alasbahibandar@gmail.com [School of Applied Physics, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor. Malaysia (Malaysia)

    2015-09-25

    This work investigated the effect on 5 wt% addition of TiO{sub 2} nanoparticles (NPs) on the optical absorption characteristics of Poly[(9,9-di-n-octylfluorenyl-2,7-diyl)-alt-(benzo[2,1,3] thiadiazol-4,8-diyl)] (F8BT). Both materials were mixed using solution blending method and then spin coated onto ITO-coated glass substrate at 1000 rpm for 30s. The optical properties of the nanocomposite were determined using UV-Vis spectroscopy. Compares to pristine film, the absorption peak of the nanocomposite film improved and shifted to longer wavelength indicating reduction in the direct and indirect band gaps. Better optophysical properties of F8BT/TiO{sub 2} nanocomposites is believed due to compatible band structures and efficient charge trapping effect displayed by the NPs.

  20. Análise de diferentes modelos para a correção geométrica de imagens orbitais de altíssima resolução

    OpenAIRE

    Marotta, Giuliano Sant'anna

    2008-01-01

    Imagens provenientes de sensores orbitais de altíssima resolução vêm sendo cada vez mais utilizadas em diversos trabalhos, tais como: confecção de base de dados para uso em Sistema de Informações Geográficas (SIG); atualização e ou confecção de mapas em escalas regionais; auxílio no planejamento e organização do espaço em âmbito regional, municipal e ou urbano; etc. A alta resolução espacial desses sensores permite a identificação de muitas feições com boa definição, e proporcionam maior faci...

  1. An integrated program of geophysical survey, coring, and test excavations to study a 4th millennium bc-cal ditch at Alt del Punxó (Muro de L’alcoi, Alacant

    Directory of Open Access Journals (Sweden)

    García Puchol, Otero

    2008-06-01

    Full Text Available The potentially long and interesting archaeological sequence revealed by systematic survey at the site of Alt Del Punxó (Muro de l’Alcoi, Alacant was the basis for initiating a study of the locality’s subsurface structures using new methods of remote sensing. Geophysical survey (magnetometry and tomography and systematic augering revealed buried structures, including monumental earthworks, and guided subsequent excavations to collect more detailed data about the nature and age of these prehistoric features. The information recovered, including new radiocarbon dates, offers a new perspective on the organization of prehistoric populations in this region of south-central Valencia since the beginning of the Holocene and is especially important for understanding the Neolithic IIB from the 4th through the early 3rd Millennium BC.

    La amplia e interesante secuencia arqueológica sugerida por los materiales de superficie del yacimiento de Alt del Punxó (Muro de l’Alcoi, Alacant ha supuesto el punto de partida para la práctica de una serie de métodos de detección de las estructuras conservadas en el lugar. La prospección geofísica (magnetometría y tomografía, y los microsondeos (augers han dirigido la planificación de la excavación con el fin de obtener nuevos datos a propósito de la naturaleza y cronología del gran foso prehistórico, así como de las diversas estructuras localizadas. La información obtenida, junto a la serie radiocarbónica disponible, abre nuevas perspectivas para el estudio del poblamiento prehistórico al aire libre en las comarcas centro-meridionales valencianas desde los inicios del Holoceno, y de un modo particular en el IV e inicios del III milenio cal AC –Neolítico IIB.

  2. Evento com aparente risco de morte: uma revisão Evento con aparente riesgo de muerte (alte: una revisión Apparent life-threatening event: a review

    Directory of Open Access Journals (Sweden)

    Mariana Tresoldi das N. Romaneli

    2012-12-01

    Full Text Available OBJETIVO: Realizar uma revisão crítica reunindo informações disponíveis a respeito dos eventos com aparente risco de morte. FONTES DE DADOS: Revisão bibliográfica dos artigos (em português, inglês e espanhol obtidos dos bancos de dados eletrônicos Medline, Lilacs e SciELO, utilizando as palavras-chave: eventos com aparente risco de morte, evento com aparente risco de vida infantil, lactente, apneia, monitorização e cianose. SÍNTESE DOS DADOS: Os eventos com aparente risco de mortesão súbitos e caracterizados por uma combinação de apneia, alteração na coloração da pele e tônus muscular, com inúmeras causas subjacentes. Sua incidência verdadeira é desconhecida e a faixa etária mais acometida é de 11 a 12 semanas. Não há correlação entre o evento com aparente risco de morte e a síndrome da morte súbita do lactente, embora já tenham sido consideradas manifestações da mesma doença. Muitas vezes, o lactente tem aparência saudável ao ser avaliado pelo pediatra após apresentar eventos com aparente risco de morte, porém, isso não afasta a possibilidade de existir uma doença grave associada ao evento, que deve ser investigada e tratada. Quando não são encontradas as causas, o evento é idiopático, geralmente com boa evolução. CONCLUSÕES: É necessário investigar os lactentes levados ao pronto-socorro após apresentarem eventos com aparente risco de morte, devido ao risco de sequelas e mortalidade. Não há uma padronização das condutas a serem realizadas diante de um lactente com aparência saudável que tenha evento com aparente risco de morte, mas recomenda-se que o paciente seja internado e a causa do evento, investigada. A observação e o monitoramento em ambiente hospitalar devem ocorrer no mínimo 24 horas após o evento.OBJETIVO: Realizar una revisión crítica, reuniendo las informaciones disponibles respecto a los Eventos con Aparente Riesgo de Muerte (ALTE - Apparent life-threatening event

  3. Déconstruction-reconstruction identitaire et poétique de l’altérité dans Le procès-verbal de J-M G. Le Clézio

    Directory of Open Access Journals (Sweden)

    Abdoulaye Diouf

    2016-12-01

    Full Text Available En partant du double mouvement rhizomatique de la « déterritorialisation » et de la « reterritorialisation », cet article se propose d’étudier la conception dynamique de l’identité dans Le procès-verbal de Jean-Marie Gustave Le Clézio (1963. Pour cela, il explore, d’une part, le processus graduel de déconstruction identitaire du héros du roman (marginalité, nudité, métamorphose par le biais de la médiation altéritaire – dans le sens d’un rapport au monde et à l’Autre – à partir de laquelle se reconstruit une nouvelle identité transcendante loin de tout essentialisme. D’autre part, il analyse les différentes stratégies de mise en altérité qui montrent au passage, avec sa théorie de l’« extase matérialiste » et le principe de l’identification qui la sous-tend, que l’être ne s’arrête pas à l’humain chez Le Clézio. Starting from the dual rhizome-like movement of the “deterritorialization” and “reterritorialization”, this article proposes to study the dynamic concept of identity in Le procès-verbal by Jean-Marie Gustave Le Clézio (1963. For this, it explores, firstly, the gradual process of identity deconstruction of the novel’s hero (marginality, nudity, metamorphosis through the othering mediation - in the sense of a relationship to the world and the Other - from which is rebuilt a new transcendent identity away from all essentialism. Furthermore, it analyzes the different otherness implementation strategies that show the way, with his theory of “materialistic ecstasy” and the principle of identification which underlies it, according to which being goes beyond humans for Le Clézio.

  4. miR-380-5p-mediated repression of TEP1 and TSPYL5 interferes with telomerase activity and favours the emergence of an “ALT-like” phenotype in diffuse malignant peritoneal mesothelioma cells

    Directory of Open Access Journals (Sweden)

    Graziella Cimino-Reale

    2017-07-01

    features (e.g. c-circle DNA and reduced expression levels of chromatin remodeler ATRX resembling an alternative lengthening of telomeres (ALT phenotype. Conclusions miR-380-5p interferes with TA in DMPM cells by targeting TEP1. Notably, in the long-term setting, miR-380-5p-mediated impairment of TA did not result in telomere attrition. Instead, a phenotype reminiscent of ALT emerged in DMPM cells as possible compensatory pathway that safeguards DMPM cell growth, an event that may be regarded as a potential resistance mechanism to anticancer therapies based on telomerase inhibitors.

  5. Jeg kommunikerer - altså er jeg

    DEFF Research Database (Denmark)

    Bonde, Lisbeth

    2015-01-01

    Udstillingen har fået den sigende titel Ruptures – eller brud, der nok engang indrammer den livssituation, som Ai Weiwei befinder sig i efter interneringen i 80 dage i 2011 i et fængsel et ukendt sted i Kina, hvor han blev overvåget 24/7. Derefter måtte han bryde med sin hidtidige praksis, bl.a. ...... eksempelvis godkendt af Ai Weiwei på Skype. Som Superman på internettet når Ai Weiwei således stadig ud til et meget stort publikum på trods af sin ”husarrest.”...

  6. Nelikvedu alt ei vea / Jussa Nieminen

    Index Scriptorium Estoniae

    Nieminen, Jussa

    2016-01-01

    Võrdlustestis talveauto 2016: Audi A4 Lim. 2,0 TDI Quattro S tronic, BMW X1 xDrive20d A, Fiat 500X 2,0 140 MJet AWD AT Cross, Ford S-Max 2,0 TDCi 180 hj PowerShift Titanium AWD, Hyundai Tucson 1,6 T-GDI 7DCT Style, Kia Sportage 1,6T GT-Line 7DCT, Land Rover Discovery Sport 2,0 TD4 180 HSE A, Mazda CX-3 2,0 Skyactiv-G AWD Premium Plus AT, Mercedes-Benz GLC 250 d 4Matic, Renault Kadjar 1,6 dCi 4×4 Bose, Škoda Superb Combi 2,0 TDI SCR DSG 4×4 L&K, Ssangyong Korando D20 AWD 6AT, Subaru Levorg 1,6i GT-N CVT, Suzuki Vitara 1,4 Boosterjet 4WD S 6MT, Volvo V60 Cross Country D4 AWD Inscription A Võrdluseks esiveoline: Toyota Auris Touring Sports1,8 Hybrid e-CVT Active

  7. Alt av kærleika

    DEFF Research Database (Denmark)

    Joensen, Dagny

    I begyndelse af 1960’erne blev der bygget en Nato-radarstation på Færøerne, og den var de første år bemandet med amerikanske eksperter. Flere færøske kvinder blev gift med disse amerikanere og fulgte med dem tilbage til USA. I denne bog interviewes en række af disse kvinder...

  8. Lenna Kuurmaa üllatas / Ode Alt

    Index Scriptorium Estoniae

    Alt, Ode

    2008-01-01

    Rainer Sarneti noortefilm "Kuhu põgenevad hinged?", stsenaariumi aluseks on Aidi Valliku romaanid Annist, kaasstsenarist Peeter Sauter, osades Ragne Veensalu, Lenna Kuurmaa jt. Filmi tootja Exitfilm. Loo autor on Tartu Descartes'i Lütseumi 12. klassi õpilane

  9. Comportamento balístico de compósito de polietileno de altíssimo peso molecular: efeito da radiação gama Ballistic behaviour of ultra-high molecular weight polyethylene: effect of gamma radiation

    Directory of Open Access Journals (Sweden)

    Andreia L. S. Alves

    2004-06-01

    Full Text Available Os materiais compósitos de matriz polimérica (PMCs reforçados por fibras são considerados excelentes materiais de engenharia. Em aplicações estruturais, quando uma elevada relação resistência peso é fundamental para o projeto, os PMCs vêm substituindo com sucesso diversos materiais convencionais. Materiais têxteis são utilizados, desde a 2ª Guerra Mundial, como blindagens balísticas. Materiais fabricados com fibra do polietileno de altíssimo peso molecular (UHMWPE são empregados na produção de blindagens, para proteção pessoal e em carros de combate. Todavia, em virtude de terem sido desenvolvidos e comercializados mais recentemente, não existem informações suficientes sobre o desempenho balístico desses materiais após a sua exposição aos agentes ambientais. No presente trabalho foi estudado o comportamento balístico de placas compósitas fabricadas com fibra de polietileno de altíssimo peso molecular (UHMWPE, após sua exposição à radiação gama. Os resultados dos testes balísticos foram relacionados com as alterações macromoleculares induzidas pela irradiação por meio de ensaios mecânicos (dureza, impacto e flexão e físico-químicos (espectroscopia no infravermelho, calorimetria diferencial de varredura e análise termogravimétrica. Foi verificado que a irradiação gama provoca modificações nas cadeias macromoleculares do polímero, que alteram as propriedades mecânicas do compósito de UHMWPE, reduzindo, nas doses de radiação mais elevadas, o seu desempenho balístico. Estes resultados são apresentados e discutidos.The fiber reinforced polymer matrix composites (PMCs are considered excellent engineering materials. In structural applications, when a high strength-to-weight ratio is fundamental for the design, PMCs are successfully replacing many conventional materials. Since World War II textile materials have been used as ballistic armor. Materials manufactured with ultrahigh molecular weight

  10. Zile Elbaşoğlu Camii’nin Sıvalar Altında Kalan Gizemi The Mystery Of The Zile-Elbaşoğlu Mosque Remains Under Plasters

    Directory of Open Access Journals (Sweden)

    Ali Murat AKTEMUR

    2013-09-01

    örtgen planlı Elbaşoğlu Camii yöredeki ahşap destekli ve ahşap tavanlı cami örneklerinden biridir. 2011 yılına kadar duvarları ve tavanındaki, hatta mihrap, ahşap destek, ahşap sütunce, ahşap mahfil, galeriler yani kısaca caminin tüm ahşap unsurları tatlı-kireç sıva üzerine yağlıboya ile kaplıydı. 2011 yılında çatıdan akan sulardan dolayı yapılan basit onarım sırasında tesadüfen düşen sıva altında kalem-işi süslemeler ve ahşap dekorasyon örneklerinin çıkması üzerine onarım durdurulmuş ardından Vakıflar Genel Müdürlüğü idaresinde yapılan temizlik ve raspa işlemleriyle caminin iç mekanındaki zengin kalem-işi örnekleri, ahşap dekorasyon örnekleri ile sıva altında kalan gizem ortaya çıkarılmıştır.Harim kısmında duvarların üst örtü ile birleştiği noktalar siyah zemin üzerine sülüs-hat ile yazılmış ayet kuşağının yer aldığı bir içbükey bordürle çerçevelenmiştir. Ayet kuşağının üstündeki pervazlarla yükseltilen tavanın köşeleri çıtaların çakılması sonucu oluşturulmuş, üçgen yüzeylere bölünmüş ve böylece ortada sekizgen bir alan oluşturulmuştur. sekizgenin tam ortasında yer alan sekizgen formlu göbek, oyma tekniği ile işlenmiş, barok karakterli bitkisel motiflerle dekore edilmiştir. Tavanın dört köşesinde aşırı plastik bitkisel kabartmaların dekore ettiği üçgen panolar yer alır. Duvarlarda bitkisel motifli kalem-işi süslemeler, mahfil, minber, sütunce gibi ahşap unsurlarda da oyma tekniği ile işlenmiş bitkisel ve geometrik motifler cami içerisinde adeta boş yer kalmamacasına göz alıcı bir zenginlik sunmaktadır.1801 yılında yapılan, Cumhuriyetin ilk yıllarında da yöreye özgü tatlı-kireç sıvayla kapatılıp üstüne boya çekilen bu zengin dekorasyon, Türk ahşap sanatının ve kalem-işi süslemeciliğinin en zengin örneklerini sunmaktadır.

  11. P-15: U-19 Futbol Takımı Oyuncularının Aerobik Kapasite ve Süratlerinin, Alt Ekstremite İzokinetik Kas Kuvveti ile İlişkilendirilmesi

    Directory of Open Access Journals (Sweden)

    Gökhan Deliceoğlu

    2017-03-01

    Full Text Available Araştırmanın amacını U-19 futbol takımı oyuncularının aerobik kapasite ve süratlerinin, alt ekstremite kuvveti ile ilişkilendirilmesi oluşturmaktadır. Araştırmaya U-19 kategorisindeki (Xyaş=18,17±0,53 yıl; Xva=73,16±5,95 kg; Xbu=178,22 ± 5,95 cm 15 futbolcu katıldı. Futbolcuların aerobik kapasiteleri Cosmed K5 © ile, alt ekstremite hamstring (H ve quadriseps (Q kas kuvvetleri ISOMED 2000 © İzokinetik Cihazı ile, sürat değerleri optojump © cihazı ile ölçüldü. Diz fleksör ve ekstansör kaslarının kas kuvveti 60°/sn açısal hızda 5 tekrarla, diz ekstansörlerinin kassal enduransı 180°/sn açısal hızda 30 tekrarla değerlendirildi. Futbolcular bir saat dinlendikten sonra, 10 dakika ısındı ve sonra ortalama hızın elde edilmesi için Optojump ile 30 m sürat testi iki kez uygulandı. Sporcular aerobik kapasitelerinin ölçülmesi için Cosmed K5 cihazı ile Bruce protokolünde koşturuldu. Futbolcuların maxVO2 ve ortalama hız değeri ile baskın ve baskın olmayan taraf diz fleksör ve ekstansör kaslarının kas kuvveti ile diz ekstansörlerinin kassal enduransı arasındaki ilişkinin belirlenmesi için SPSS 17,0’de regresyon analizi yapıldı. Analiz sonuçlarına göre, maxVO2 (X=51,84±7,56 ml/dk/kg ile baskın taraf 60 °/sn açısal hızdaki (Xfle=137,01 ±35,48 Nm; Xeks=239,26 ±57,96 Nm kuvvet değerleri arasında istatistiksel olarak anlamlı bir ilişki görüldü (R=759, R2=,576, p0.05. Futbolculardan elde edilen maxVO2 değerleri ile baskın olmayan taraf 60°/sn açısal hızdaki temel kas kuvveti (Xfle=140,62 ±34,11 Nm; Xeks=253,21 ±71,54 Nm ile 180/sn açısal hızda baskın taraf (X=66,86±8,16 ve baskın olmayan taraf kassal endurans (X=66,43±10,26 değerleri arasında anlamlı bir ilişki görülmedi (p>0.05. Futbolcularda baskın taraf diz fleksör ve ekstensör izokinetik kas kuvvet değerleri ile maxVO2 ve ortalama sürat değerleri arasında anlamlı bir ilişki g

  12. Zihin Özürlü Öğrencilere Okuma Yazma Öğretme Konusunda Alt Özel Sınıf Öğretmenlerinin Görüş ve Önerileri

    Directory of Open Access Journals (Sweden)

    Mine Başal

    2002-07-01

    Full Text Available Niteliksel olarak planlanan bu araştırmanın amacı, zihin özürlü öğrencilere okuma yazma öğretme konusunda alt özel sınıf öğretmenlerinin görüş ve Önerilerini incelemektir. Araştırmanın verileri yarı-yapılandırılmış görüşmeler aracılığı ile toplanmıştır. Eskişehir ilinde bulunan yedi ali Özel sınıfın özel eğitim bölümü mezunu olmayan öğretmeni araştırmanın katılımcılarını oluşturmuştur. Görüşmeler 25-70 dakika arasında sürmüştür. Tümevarım yoluyla analiz edilen verilerden 29 temaya ulaşılmıştır. Daha sonra birleştirilerek 10 tema haline getirilen araştırmanın bulguları, öğretmenlerin okuma yazma öğretimine yönelik amaçlarım belirlemede farklı yollar izlediklerini, okuma yazma öğretiminde genellikle cümle yöntemini kullandıklarını ancak gerektiğinde farklı yöntemlerden de yararlandıklarını, aileden destek olmaksızın öğretimin zor olduğunu, araç-gereç sıkıntısı, kaynak eksikliği gibi sorunların yaşandığını ortaya kovmaktadır. Araştırma bulgularının zihin özürlü Öğrencilere okuma yazma öğreten öğretmenlere, özel eğitim bölümlerinde okuma yazma öğretimi lisans dersini okutan öğretim elemanlarına yol göstereceği düşünülmekledir. The purpose of the present study was to examine the opinions and suggestions of the teachers of special education classes towards leaching reading and writing to students with mental retardation. The data of the qualitative study were collected via semi-structured interviews. The participants of the study were seven teachers of special education classes in Eskişehir who did not have special education degrees. Interviews lasted about 25- 70 minutes. 29 themes were derived from the data. The related themes have been consolidated and ten themes remained. The results of the study revealed that teachers prefered to use different ways in order to determine their aims about teaching

  13. Fifth and Sixth Grade Students' Deficiencies on Word Problem Solving and Failures in the Problem Solving Process [Beşinci ve Altıncı Sınıf Öğrencilerinin Sözel Problemleri Çözme Konusundaki Yetersizlikleri ve Problem Çözümlerindeki Hataları

    Directory of Open Access Journals (Sweden)

    Dilek Sezgin Memnun

    2014-08-01

    Full Text Available In this research, it was aimed to determine the deficiencies of secondary school fifth- and sixth-grade students on word problem solving and their failures in this process. For this purpose, four separate word problems were asked to the students and their written answers were taken at the implementation process. The analysis of the data suggests that a significant part of these secondary school students had deficiencies during word problem solving and their failures in this process. Moreover, these deficiencies and failures were reported to be related to the understanding of word problems and the planning for solutions in the solving process. In addition, it was found that the fifth- and sixth- grade students rarely attempted to use drawing in order to solve the word problems. They mostly had deficiencies in deciding which arithmetic operations to be used while approaching the problems and they had failures at their arithmetic operations. [Bu araştırmada, ortaokul beşinci ve altıncı sınıf öğrencilerinin sözel problemleri çözme konusundaki yetersizlikleri ile bu tür problem çözümlerindeki hatalarının belirlenmesi amaçlanmıştır. Bu amaçla, beşinci ve altıncı sınıf öğrencilerine dört farklı sözel problem sorulmuş ve cevapları yazılı olarak alınmıştır. Ulaşılan verilerin analizi, ortaokul öğrencilerinin önemli bir kısmının sözel problemleri çözme konusunda yetersizlikleri ve problem çözümlerinde hataları bulunduğunu göstermiştir. Ayrıca, bu yetersizlik ve hatalarının çoğunlukla problem çözme süreci kapsamında problemin anlaşılması ve çözüm için plan yapma aşamalarına ilişkin olduğu belirlenmiştir. Bununla birlikte, beşinci ve altıncı sınıf öğrencilerinin sözel problem çözümlerinde şekil çizmeye çok az yer verdikleri anlaşılmıştır. Öğrenciler problemlere yaklaşımlarında kullanacakları uygun aritmetik işlemlere karar vermede çoğunlukla yetersiz

  14. Performance of spray deposited poly [N-9″-hepta-decanyl-2,7-carbazole-alt-5,5-(4′,7′-di-2-thienyl-2′,1′, 3′-benzothiadiazole)]/[6,6]-phenyl-C61-butyric acid methyl ester blend active layer based bulk heterojunction organic solar cell devices

    International Nuclear Information System (INIS)

    Saitoh, Leona; Babu, R. Ramesh; Kannappan, Santhakumar; Kojima, Kenzo; Mizutani, Teruyoshi; Ochiai, Shizuyasu

    2012-01-01

    Bulk heterojunction organic solar cell devices were fabricated using the spray deposited poly [N-9″-hepta-decanyl-2,7-carbazole-alt-5,5-(4′,7′-di-2-thienyl-2′,1′, 3′-benzothiadiazole)]/[6,6]-phenyl-C61-butyric acid methyl ester blend active layer. The spray coating parameters such as spraying time, substrate-nozzle distance for the deposition of active layers were analyzed. Optical absorption of the active layers was analyzed using UV–visible spectral studies in the wavelength range from 300 to 800 nm. The surface morphology of the active layers deposited with different parameters was examined using atomic force microscopy. Surface morphology of the active layers deposited with the substrate-nozzle distance of 20 cm and for 20 s shows smooth morphology with peak-valley value of 4 nm. The devices fabricated using the selected active layer show overall power conversion efficiency of 1.08%. - Graphical abstract: Current–voltage (J–V) characteristics of spray deposited PCDTBT:PC 61 BM active layer based solar cell device under illumination of AM 1.5 G, 100 mW/cm 2 . Highlights: ► Organic solar cells were fabricated using a spray deposited PCDTBT:PC61BM active layer. ► The active layers deposited with spray conditions show flat morphology. ► Using the selected active layers power conversion efficiency of 1.08% is obtained.

  15. Neue Laser und Strahlquellen - alte und neue Risiken?

    DEFF Research Database (Denmark)

    Paasch, Uwe; Schwandt, Antje; Seeber, Nikolaus

    2017-01-01

    Die Entwicklungen im Bereich dermatologischer Laser, hochenergetischer Blitzlampen, LED und neuer Energie- und Strahlquellen der letzten Jahre haben gezeigt, dass mit neuen Wellenlängen, Konzepten und Kombinationen zusätzliche, zum Teil über den ästhetischen Bereich hinaus gehende therapeutische ...

  16. Teorien om alt og andre artikler om sprog og filosofi

    DEFF Research Database (Denmark)

    Artikelsamling i anledning af Peter Widells 60-års fødselsdag, med emnerne: 1. Stilistik og litteraturvidenskab  (7 artikler), 2. Leksikografi, semantik og grammatik (10 artikler), 3. Sprogfilosofi, sprogpsykologi og metaforteori (10 artikler)....

  17. Army AL&T, October-December 2007

    Science.gov (United States)

    2007-12-01

    appearance. The results of this research have been exploited in movies such as Spider Man II, Superman Returns and King Kong. A new challenge being...project manager/superintendent and quality control manager at LEAD who work from an office trailer in the depot’s industrial area. The availability of...and I think AMC as a command is much better to do that for the Army. The 3.5-day event also included a tour of and reception at the U.S. Army

  18. Køn vikler sig ind i alt

    DEFF Research Database (Denmark)

    Henningsen, Inge; Søndergaard, Dorte Marie

    2016-01-01

    Ligestilling er emnet for FN’s Verdensmål 5, der i den danske version er formuleret med en overskrift om at: ‘Opnå ligestilling mellem kønnene og styrke kvinders og pigers rettigheder og muligheder’. I FN’s generalforsamlings resolution af 25. september 2015 Transforming our world: the 2030 Agend...

  19. Mustad silmad paadi ääre alt / Aarne Ruben

    Index Scriptorium Estoniae

    Ruben, Aarne, 1971-

    2008-01-01

    Allfilmi ja DeforeFilmi koostöös toodetud dokumentaalfilm "Surmaretk" - 1997. aasta 11. septembri traagilisest sõjaväeõppusest, kus hukkus 14 Eesti kaitseväelast. Esilinastus 10. septembril Kinos Sõprus

  20. Ein altes Problem: Partikeln in der Grammatik - ja, aber wie?

    Directory of Open Access Journals (Sweden)

    Kärnä, Aino

    2005-01-01

    Full Text Available This article deals with the concept 'particle', specifically with the German notion of 'Abtönungspartikel'. These pragmatic or modal particles were first discussed in contemporary German grammars by Harald Weydt. Although the concept itself is clear, it is difficult to include such a category in existing grammars, as is shown by the treatment of such inflexible words in different editions of the standard German grammar, Der Duden. It seems difficult to formulate a description of the word class 'particle' in such a way that it includes pragmatic particles as well as other kinds of particles, such as focus particles. This problem is not new, and I also discuss parallels from the history of linguistics.

  1. Alment, afgrænset, altædende

    DEFF Research Database (Denmark)

    Eriksson, Birgit

    2006-01-01

    Artiklen omhandler smagens funktionsforandring. Gennem tre historiske nedslag belyser jeg, hvordan teorierne om den kulturelle smags relation til det sociale liv har forandret sig. Udgangspunktet er den tidligt moderne forestilling om kultivering af smagen, som den blev formuleret af Immanuel Kant...

  2. Aia alt pilvekatusega kunstisaali / Meeli Müüripeal

    Index Scriptorium Estoniae

    Müüripeal, Meeli, 1963-

    2006-01-01

    Sabile restaureeritud sünagoog-kunstisaalist (1890).1993. a. läti skulptori Ojars Arvids Feldbergsi (sünd. 1947) poolt avatud Pedvale keskkonnakunsti keskusest, sealsetest Brinkpedvale (18. sajand) ja Frikspedvale mõisahoonetest. 1999. a. pälvis Pedvale vabaõhu kunstisaal UNESCO Melina Mercouri auhinna. Pedvales on tuleetendusega esinenud Raul Meel, eesti kunstnike töödest nimetatud Villu Jaanisoo töö "Tugitool". 16 ill

  3. #AltPlanets: Exploring the Exoplanet Catalogue with Neural Networks

    Science.gov (United States)

    Laneuville, M.; Tasker, E. J.; Guttenberg, N.

    2017-12-01

    The launch of Kepler in 2009 brought the number of known exoplanets into the thousands, in a growth explosion that shows no sign of abating. While the data available for individual planets is presently typically restricted to orbital and bulk properties, the quantity of data points allows the potential for meaningful statistical analysis. It is not clear how planet mass, radius, orbital path, stellar properties and neighbouring planets influence one another, therefore it seems inevitable that patterns will be missed simply due to the difficulty of including so many dimensions. Even simple trends may be overlooked if they fall outside our expectation of planet formation; a strong risk in a field where new discoveries have destroyed theories from the first observations of hot Jupiters. A possible way forward is to take advantage of the capabilities of neural network autoencoders. The idea of such algorithms is to learn a representation (encoding) of the data in a lower dimension space, without a priori knowledge about links between the elements. This encoding space can then be used to discover the strongest correlations in the original dataset.The key point is that trends identified by a neural network are independent of any previous analysis and pre-conceived ideas about physical processes. Results can reveal new relationships between planet properties and verify existing trends. We applied this concept to study data from the NASA Exoplanet Archive and while we have begun to explore the potential use of neural networks for exoplanet data, there are many possible extensions. For example, the network can produce a large number of 'alternative planets' whose statistics should match the current distribution. This larger dataset could highlight gaps in the parameter space or indicate observations are missing particular regimes. This could guide instrument proposals towards objects liable to yield the most information.

  4. Sculpture africaine. Blessures et altérité

    Directory of Open Access Journals (Sweden)

    Gaetano Speranza

    2009-03-01

    Full Text Available Au delà de la notion de “blessure” relative à l’objet, l’auteur s’attache aux traumatismes culturels résultant de la rencontre entre la sculpture africaine et le monde occidental. Un exemple particulier est celui des instruments de musique ethnographiques, dont la restauration est souvent tributaire des conceptions occidentales.Beyond the notion of « injury » for the object, the author dwells on cultural traumatisms resulting from the meeting between African sculpture and the western world. A particular example is the one of ethnographical musical instruments for which restoration is often tributary of western conceptions.

  5. Ødelæg alt muligt med et bogstav

    DEFF Research Database (Denmark)

    Konzack, Lars

    2017-01-01

    En gang imellem griber en raptus SoMe-Danmark, og så fyldes alles feed med samme slags indhold. Senest overspringshandlede vi med hashtagget #oedelaeg1filmed1bogstav - og alle mulige afledninger af det....

  6. 03 Hutchings_alt_ithenticate edit.indd

    African Journals Online (AJOL)

    denise

    asymptotic length than De Hoop fish and mean length-at-age (for ages 2–10 years) was significantly greater. ...... Biogeography of sponge chemical ecology: comparisons of ... A zoogeographic and functional approach to the selection of.

  7. 'Alting som kører paa Motor'

    DEFF Research Database (Denmark)

    Wagner, Michael

    2012-01-01

    , constructed, represented, and appropriated as a leisure culture after 1900 through a mediation and consumption junction that was initiated and promote by the automobile consumer organisation United Danish Motorowners (FDM). This is basically the story of unlimited access to Sunday driving or the daytrip...

  8. Görsellerle Desteklenmiş Altı Şapka Düşünme Tekniğinin Öğrencilerin Konuşma Becerilerini Geliştirmesine Etkisi Six Thinking Hats Technique Supported Visuals Effects of Students' Speaking Skills Develop

    Directory of Open Access Journals (Sweden)

    Salih ORHAN

    2012-09-01

    dil becerisi olan konuşmanın daha etkili olarak kullanılabilmesi için çeşitli yöntemler kullanılmaktadır. Bu araştırmanın temel amacı, ilköğretim öğrencilerinin konuşma becerilerini geliştirmede görsellerle desteklenmiş altı şapkalı düşünme tekniğinin geleneksel yönteme göre etkisini belirlemektir. Bu amaçla, bu teknik ilköğretim 8. sınıf öğrencilerine 4 hafta süreyle „Bilim ve Teknoloji‟ temasında uygulanmıştır. Araştırmanın verileri “Konuşma Becerisi Gözlem Formu” (Orhan, 2010 aracılığıyla toplanmıştır. Deney grubunda görsellerle desteklenmiş konuşma çalışmaları yapılırken, kontrol grubunda ise geleneksel yönteme göre konuşma çalışmaları yapılmıştır. Bu bağlamda deney grubundaki öğrencilere öncelikle yöntem hakkında bilgi verilmiş, öğrencilerin bu yöntemi nasıl uygulayacakları araştırmacı tarafından öğrencilere anlatılmıştır. Daha sonra altı şapkalı düşünme tekniğinin her bir rengi için belirlenen resimler öğrencilere dağıtılarak konuşma çalışması yaptırılmıştır. Araştırmanın verileri SPSS 19.0 ile değerlendirilmiş, grupların kendi içinde ön test-son test karşılaştırmaları için ise “ilişkili Ölçümler için Wilcoxon işaretli Sıralar Testi” kullanılmıştır. Araştırma sonucunda „konuşma kuralarını uygulama, sesini ve beden dilini etkili kullanma, hazırlıklı konuşmalar yapma, kendi konuşmasını değerlendirme‟ gibi Türkçe Ders Programı‟nda yer alan konuşma amaç ve kazanımlarını geliştirmede deney grubu öğrencilerinin kontrol grubu öğrencilerine göre daha başarılı olduğu tespit edilmiş ve çeşitli öneriler getirilerek öğretmenlerin konuşma becerisi ile ilgili uygulamalarda bu yöntemi kullanabilecekleri ifade edilmiştir.

  9. Bilimsel iletişimde yeşil ve altın yollarda yakınsama ve Türkiye'deki yansımaları = Convergence of the gold and green roads at scholarly communication and reflections on Turkey

    Directory of Open Access Journals (Sweden)

    Şengül, Gökhan

    2011-01-01

    Full Text Available Son yıllarda özellikle sosyal ağlarda bilgi dolaşımının artması, gelişmiş mobil iletişim cihazlarının yoğun kullanımı kısıtsız ve farklı ortamlarda bilgi erişim ve paylaşımını gerektirmektedir. Bu bağlamda bilimsel bulguların yer aldığı makalelerin geniş kitlelere ve diğer bilim insanlarının erişimine açılması; hem bilimsel eserin doğruluk ve güvenirliğini artırmaya yardımcı olmakta, hem de bilimsel verinin paylaşılmasını ve dolayısı ile de bilimsel gelişimi olumlu yönde etkilemektedir. Yaklaşık on yıldır bu amaca açık erişim insiyatifi katkı sağlamaktadır. Bu amaçla kendi kendine arşivleme (yeşil yol ve açık erişim dergisi (altın yol bilimsel çalışmaların bilim topluluğuna sunulmasında yeni yöntemler olarak takdim edilmiştir Bu çalışmada; uluslararası alanda yeşil ve altın yollar üzerinde ortaya konan kurallar irdelenmiş, yazar ve yayıncılarının oluşan iklime uyumluluğu sorgulanmış ve Türkiye adresli kurumsal arşiv ve dergilerin ortaya çıkan durum karşısında konumları üzerine bir değerlendirme yapılmıştır. Çalışma esnasında Ulrich Süreli Yayın Rehberi, Thomson Reuters (ISI Bilimsel Web (Web of Science - WoS ve Elsevier Scopus uluslararası ticari atıf veri tabanları, RoMEO, Juliet, ve ROARMAP telif politikası rehberleri, OpenDOAR, ROAR kurumsal arşiv rehberleri ve DOAJ açık erişim dergisi rehberi ile ULAKBİM ulusal veri tabanları incelenmiştir. / In parallel with the increase of information exchange rate in social networks and the usage of mobile communication devices in recent years, it is also required that the information needs to be shared and freely accessable in different enviroments. In this context freely access to the papers including scientific findings by other scientists and broad population will help to increase both the accuracy and reability of the papers. Besides it will also affect positively the

  10. Birliktelik Kısıtları Altında Montaj Hattı Dengeleme Problemi İçin Bir Çözüm Yaklaşımı Önerisi ve Bir İşletmede Uygulama

    Directory of Open Access Journals (Sweden)

    Serkan Altuntaş

    2010-01-01

    Full Text Available Montaj Hattı Dengelemesinde, -çeşitli nedenlerle- belli iş elemanlarının birbirinden ayrılmaması ve aynı istasyona atanması istenebilir. Bu tür problemler, 'Birliktelik Kısıtları Altında Montaj Hattı Dengeleme (BKAMHD Problemi' olarak tanınmaktadır. Bu birliktelik kısıtı sayesinde, havaleli ürün imali, birlikte işlem görme gereği gibi özel isteklerden veya takım-kolaylık benzeri kaynakların ortak kullanımı düşüncesinden kaynaklanan 'konum ve bölge kısıtları' da karşılanabilmektedir. Bu tür hatlarda ayrıca, malzeme aktarma, takım ve kolaylık maliyetleri, yürüyüş mesafeleri, ayar süreleri ile tedarik süreleri de azalmaktadır. Uygulamada BKAMHD yapısındaki problemlerle yaygın olarak karşılaşılmasına karşın, bunlar üzerinde yapılan çalışmaların klasik montaj hattı dengeleme problemi ile ilgili yayınlara göre daha az olduğu görülmektedir. Bu çalışmanın amacı, özel konum kısıtları dolayısıyla-, bilinen Montaj Hattı Dengeleme yöntemlerinin uygulanamadığı büyük ölçekli bir montaj hattı için uygun bir hat dengeleme yöntemi geliştirmek ve bu yöntem ile söz konusu hattı dengelemek olmuştur. Çalışmanın başında, bu problemin çözümünde kullanılabilecek basit fakat etkili bir yol olarak tanınan 'En Büyük Aday' algoritmasında bazı değişiklikler yapılarak yeni bir yöntem geliştirilmiştir. Bu yöntemin uyarlanabilmesi için de montaj işlemlerinin yapıldığı atölyede çok yoğun bir metot ve zaman etüdü çalışması yürütmek gerekmiştir. Bu çalışma sonucunda derlenen verilerin geliştirilen yönteme uyarlanması sonucunda türetilen seçenekler değerlendirilerek karar vericiye sunulmuştur.

  11. Batı Karadeniz Bölgesi Düzce Ekolojik Koşulları Altında Bazı Ekmeklik Buğday Çeşitlerinin Yaprak Hastalıklarına Karşı Reaksiyonlarının Belirlenmesi

    Directory of Open Access Journals (Sweden)

    Nedim Altın

    2017-07-01

    Full Text Available Bu çalışma, Batı Karadeniz Bölgesi Düzce ili ekolojik koşulları altında 19 adet ekmeklik buğday çeşidinin doğal enfeksiyon koşullarında yaprak hastalıklarına karşı reaksiyonlarının belirlenmesi amacıyla yürütülmüştür. Deneme tesadüf blokları deneme desenine uygun olarak 4 tekerrürlü olarak kurulmuş ve ekim işlemi 17.11.2015 tarihinde yapılmıştır. Hastalık gözlemleri ile ilgili çalışmalar; Septoria tritici etmeninin neden olduğu septorya yaprak lekesi hastalığı için süt olum dönemi başlangıcında, Puccinia striiformis etmeninin neden olduğu Sarı Pas hastalığı için çiçeklenme dönemi sonunda, Puccinia recondita etmeninin neden olduğu Kahverengi Pas için süt olum dönemi başlangıcında yapılmıştır. Tarla koşullarında doğal bulaşıklığa göre yapılan değerlendirme sonucunda hastalık oranları belirlenmiştir. Belirlenen hastalık şiddetine göre, septorya yaprak lekesi hastalığına karşı en hassas çeşidin % 60 hastalık şiddeti ile “Bereket”, en tolerant çeşidin ise %14 ile “Aslı” olduğu, Sarı Pas hastalığına karşı en hassas çeşidin %45,4 ile “Tekirdağ”, en tolerant çeşidin %0,6 ile “Midas” olduğu ve Kahverengi Pas hastalığına karşı ise en hassas çeşidin %22 ile “Tahirova” en tolerant çeşidin ise %0,2 ile “Midas” olduğu belirlenmiştir. Çalışma sonucunda elde edilen verilere göre septorya yaprak lekesi hastalığına karşı Aldane, Aslı, Konya 2002, Köprü, Masaccio ve Tosunbey, Sarı Pas hastalığına karşı Aslı, Esperia, Kate A1, Karasunya Odeska, Masaccio ve Midas, Kahverengi Pas hastalığına karşı ise Aldane, Aslı, Bereket, Köprü, Masaccio, Midas ve Tekirdağ çeşitlerinin ileride yapılacak ıslah çalışmaları için ümitvar olduğu görülmüştür.

  12. İlhanlı Hâkimiyeti Altında Anadolu’da Siyasetin Temel Dinamiği: Göçebe Moğol-Türkmen Çatışması The Basic Dynamic Of Politics In Anatolia Under The Ilkhanid Rule: The Struggle Of Nomad Turcomans And Mongols

    Directory of Open Access Journals (Sweden)

    Halil ÇETİN

    2012-12-01

    ûk ve Türkiye Selçuklu devletleri ile göçebe Türkmenlerden müteşekkil bir ittifak buldular. Bunlar arasında Türkmenler, Moğolların siyasî amaçlarına ve askerî faaliyetlerine karşı en kararlı direnç noktasını oluşturmuşlardır. Gaza ülküsü gibi dinî motifler de içeren bu direniş, Türkmenlerin Anadolu’yu ısrarlı bir şekilde yurt edinme çabasının bir sonucudur. Esasen Anadolu’nun uç bölgelerine yoğun bir şekilde yerleşen Türkmenler için başka bir seçenek de kalmamıştır. Zira yarımadanın siyasî ve coğrafî sınırları onların bir başka bölgeye göçüne imkân da vermemiştir. Bunun içindir ki Türkmenlerin Anadolu’yu kararlı bir şekilde yurt edinme çabası ile Moğollara ısrarla karşı koymaları birbirini besleyen tavırlardır. Moğol ve Türkmen göçebeleri arasında uzun süren bu çatışmalar, Anadolu’da Selçuklu ve İlhanlı idaresinin çökmesiyle sonuçlanmıştır. Göçebe Türkmenler önde gelen siyasî aktörler olarak neticede Siyasal Türkmen Kimliği edinmişlerdir. XIV. asrın başlarında Anadolu’nun uç bölgelerinde ortaya çıkan Türkmen Beyliklerini kuran siyasî ve toplumsal zümrelerin bu kimliğin etkisinde oldukları görülmektedir. Örneğin Osmanlı Beyliği’nin kurucusu Osman Bey, İlhanlı hâkimiyeti altında Anadolu’da yaşanan Moğol-Türkmen çatışmasının ürünü olan siyasî yöntem, söylem ve araçları kullanmıştır.

  13. Mehmet Harmancı’nın Küçürek Öykülerindegündelik Kuşatma Altındaki İnsanın Varoluş Görüngüleri Existence Perspectives Of An Individual Under Daily Blockage In The Short Short Stories Of Mehmet Harmancı

    Directory of Open Access Journals (Sweden)

    Mutlu DEVECİ

    2013-03-01

    şme sürecinde değerlerini/ özünü koruyarak geleceğe taşınmalıdır. Diğerleri gibi kalmak, bireyleşememek, şey’ler dünyasında yitip gitmektir. İnsan gerçeğini tarihsel boyutuyla ele alan Mehmet Harmancı, öykülerinde, bireyin kendi oluşuna göndermede yapar. Anlam arayışı içerisindeki insanların; ölüm, aşk ve yalnızlık izlekleri etrafında eylem ve eylemsizliklerini dile getirir.Mehmet Harmancı Muhtemel Menkıbeler adlı eserinde yer alan küçürek öykülerinde, yaşamın anlamına yönelik sorgulamalarda bulunur. Türler arası geçişkenliğin dikkat çektiği bu eserde yazar, menkıbe türünün imkânlarını aşarak küçürek öykü türüne özgü bir anlatım yolu seçer. Öykülerde, şimdi’yi vareden değerler, geçmişin izdüşümünde kurulur ve gündelik kuşatma altındaki insanın varoluş görüngüleri sergilenir.Mehmet Harmancı, geleneğin izdüşümünde kurduğu Muhtemel Menkıbeler’inde moderniteyi ıskalamadan geleneği de modern olana ezdirmeden yol alır. Yazar, değerlerini yok sayarak medeniyet kurmaya çalışanlara karşı geleneği, modern dünyanın fenomenolojik temeli sayar. Bu açıdan modernite olarak kabul ettirilmeye çalışılan dünya/ yaşam yerine, temeli geleneğe dayalı bir modern dünya arzusu taşır. Muhtemel Menkıbeler’deki öykülerin pek çoğu böylesi bir ruh dünyasına aittir.Muhtemel Menkıbeler’deki öykülerde, geleneğin deneyimsel, kültürel ve nesneler belleğini başat değer olarak kabul eden yazar, yaşamın anlam arayışına yönelik sorgulamaları ile yol göstericilik özelliğini ön plana çıkarır.Çalışmada, Mehmet Harmancı’nın Muhtemel Menkıbeler adlı eserinde yer alan öyküleri analiz edilirken, menkıbe ile küçürek öykü türleri arasındaki ilişkiye dikkat çekilerek; gelenek ile modernite arasındaki insan görüngülerine yer verildi.

  14. Tersane Yatırımları İçin Kuruluş Yeri Seçimi: Yalova-Altınova Tersane Girişimcileri Sanayi ve Ticaret Anonim Şirketi Örneği

    Directory of Open Access Journals (Sweden)

    Yeşim ALİEFENDİOĞLU

    2015-06-01

    Full Text Available Bu çalışmada, emek yoğun sektör olması ve birçok sanayi dalı ile etkileşim içinde olması sebebiyle yüksek istihdam olanağı sağlayan, yüksek katma değerli ürünleri ile ihracatta önemli katkı yapan, ülke ekonomisine döviz geliri sağlayan ve savunma sanayiine katkısı ile teknolojik altyapının gelişmesine olanak sağlayan gemi inşa sektöründe kuruluş yeri seçimi hem genel, hem de seçilmiş örnek olay düzeyinde irdelenmiştir. Tersane proje geliştiricisi ve yöneticileri yönünden kuruluş yeri seçim kriterleri değerlendirildiğinde; coğrafi konum, ulaşım olanakları, gemi sanayinin varlığı, gemi inşa yan sanayinin varlığı, devlet teşviki, toplam ve nitelikli işgücü varlığı, jeolojik durum, topografik yapı, enerji kaynaklarının yeterliliği, altyapı yatırımları, kıyı kesiminin özelliği, dalga etkisi, rüzgar etkisi, diğer tersane bölgelerine uzaklığı, bölgenin sosyo-kültürel yapısı, havalimanına yakınlığı, stratejik durumu, hammaddeye yakınlığı, öz kaynakların ve ilave tesis alanlarının önemi, arazi ve arsa varlığı, su kaynaklarının varlığı ve konaklama tesislerinin varlığı gibi parametrelerin önemli olduğu ortaya konulmuştur. Kuruluş yeri seçiminde tersane kuruluşunu gerektirecek iş hacminin tespiti ile tersane kuruluş yerinin uluslararası kriterlere uygunluğu parametrelerinin de önem taşıdığı sonucuna ulaşılmıştır. Örnek olay olarak incelenen Yalova-Altınova Tersaneler Bölgesi ve seçilen tesisin yer seçiminin, belirtilen kuruluş yeri seçim kriterlerine uygun olduğu görülmektedir. Tersane yatırımlarının geliştirilmesi ve özellikle gemi sanayinde üretim ve ihracat kapasitesinin geliştirilmesi bakımından bütün kıyı yerleşimlerinde tersane kuruluş yeri seçimi ve fiilen yatırıma başlanmasına yönelik master plan hazırlanması ve buna göre yatırımların ulusal ve bölgesel düzeylerde y

  15. Impact of Diagenetic Alterations on the Petrophysical and Multiphase Flow Properties of Carbonate Rocks Using a Reactive Pore Network Modeling Approach Impact des altérations diagénétiques sur les propriétés pétrophysiques et d’écoulement polyphasique de roches carbonates en utilisant une modélisation par l’approche réseau de pores

    Directory of Open Access Journals (Sweden)

    Algive L.

    2012-02-01

    replacing the original complex pore structure of real porous media by a conceptual network. The second step consists of resolving the governing equations of the precipitation and dissolution phenomena (i.e. reactive convection diffusion equation in the conceptual 3D pore network and deducing the local reactive fluxes and the motion of the fluid-solid interface. The third step consists of updating the new pore structure and calculating the new petrophysical properties of the modified porous media. Those steps are repeated in order to mimic a given diagenetic scenario. Finally, the multiphase flow properties of the current porous media are calculated. The impact of one diagenetic cycle of dissolution and precipitation on the pore networks’ heterogeneity and consequently on the petrophysical properties (i.e. porosity and permeability and multiphase flow properties (i.e. relative permeability and capillary pressure have been investigated. The permeability and porosity evolution during a given diagenetic cycle are calculated and analyzed as a function of the relevant dimensionless numbers (Peclet and Damköhler numbers that characterize the flow and reaction regime. The correlation between these numbers and the dissolved/precipitated layer thickness distribution is investigated. This work contributes to improve the understanding of the impact of dissolution and precipitation on permeability and porosity modification. Using the PNM approach, multiphase flow properties and permeability-porosity relationship have been determined for different reactive flow regimes. These relationships are relevant input data to improve the quality of reservoir simulation predictions. Les roches sédimentaires présentent souvent une structure porale hétérogène qui est intrinsèquement liée à la texture de la roche d’origine et aux modifications diagénétiques subies. Ces altérations sont régies par la texture de la roche d’origine, les fluides impliqués (et les interactions rock

  16. The 'Alte Ziegelei' small hydro-power installation in Derendingen, Switzerland; Kleinwasserkraftwerk alte Ziegelei in Derendingen. Programm Kleinwasserkraftwerke. Erfahrungs- und Schlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    Koehli, T.

    2006-07-01

    This final report for the Swiss Federal Office of Energy (SFOE) discusses the experience gained with a small hydro-power installation in Derendingen, Switzerland. This unique 'micro' installation uses an archimedian screw to produce 6.8 kW of power from a head of 1.15 m and a through-flow of 800 - 1000 litres per second. Optimisation of the project is discussed as are the effects of changing water levels above and below the screw. Winter operation is described and the mounting of gratings necessary to avoid the intake of debris is discussed. Fish-passes are looked at and the effort required for maintenance is compared with that for other types of installations. An accident that occurred is analysed and the results of energy-efficiency measurements made on the installation are presented. The report is rounded off with an evaluation of the plant's performance and a review of future work to be done.

  17. Kaitsja taotleb Herman Simmi vahi alt vabastamist / Kärt Anvelt

    Index Scriptorium Estoniae

    Anvelt, Kärt, 1973-

    2008-01-01

    Riigi juhtivprokuröri Lavly Lepa sõnul pole prokuratuur Herman Simmi vabastamist kaalunud. Riigiprokuratuuri teatel võis H. Simm edastada salajast infot isikule, kes kasutas ühe EL-i liikmesriigi kodaniku identiteeti ning kes võis olla Vene välisluureteenistuse ohvitser. Ajakirja The Economist andmeil oli H. Simmi kontaktisik üks enda väitel Itaalia heaks töötav Hispaania kodanik

  18. Valupunktidest ja vanamuusika jõujoontest Innsbrucki rakursi alt / Saale Kareda

    Index Scriptorium Estoniae

    Kareda, Saale, 1968-

    2009-01-01

    Vanamuusika ajastutruu esitlustraditsiooni elushoidmisest, Innsbrucki vanamuusikafestivali korraldusest - festivali kunstiline juht Rene Jacobs lahkub Innsbrucki vanamuusika festivali kunstilise juhi kohalt, korralduse võtavad üle Alessandro DeMarchi ja Crista Redik

  19. Conservation de manuscrits altérés par les encres ferrogalliques

    DEFF Research Database (Denmark)

    Rouchon, Veronique; Duranton, Maroussia; Belhadj, Oulfa

    2013-01-01

    -oxidant charged papers. Interleaving treatment consists in pressing the document between two interleaves, at ambient temperature and in high humidity conditions in order to provoke the migration of active components from the interleaves to the document. The use of high humidity conditions may provoke a migration...... of ink components from the ink line to the paper which is prejudicial to the future conservation of the document. Tests, performed on a set of 53 original manuscripts, led us consider that a relative humidity of 80% was minimizing this risk. The efficiency of interleaving treatment was then evaluated...

  20. Danske metoder kan hjælpe med at bremse alt fra ebola til fugleinfluenza

    DEFF Research Database (Denmark)

    Kirkeby, Carsten Thure

    2017-01-01

    Smitsomme sygdomme er et stort problem. Ikke kun for mennesker, men også for dyr. Køer og grise i Danmark bliver ofte syge af smitsomme sygdomme som yverbetændelse eller diarre. Det koster landbruget og samfundet mindst 280 millioner kroner hvert år og giver selvsagt også dårligere dyrevelfærd. D...

  1. Renaissance des Mittelalters (Teil 2) : oder Alte Fragen mit Neuen Antworten

    NARCIS (Netherlands)

    drs. Frans van den Reep

    2014-01-01

    Frans van der Reep widmete sich im ersten Teil seines Kommentars (KM Magazin, Nr. 90, Juni 2014) den überraschenden Parallelen zwischen dem digitalen Heute und dem weit entfernten, mittelalterlichen Gestern. In dieser Ausgabe setzt er dies fort und führt die Gedankenkette hin zu den Ähnlichkeiten

  2. Renaissance des Mittelalters (Teil 1) : oder Alte Fragen mit Neuen Antworten

    NARCIS (Netherlands)

    drs. Frans van den Reep

    2014-01-01

    Man kann das Heute mit keiner Zeit vorher vergleichen? Zu schnell sind die Veränderungen, zu gravierend die technologischen Möglichkeiten der Digitalisierung, des Internets? Frans van der Reep nähert sich in vielen überraschenden Parallelen in der gesellschaftlichen Entwicklung dem Gestern und

  3. Giles Merritt: Euroopa Liit vedas inimesi alt / Giles Merritt ; interv. Liisa Past

    Index Scriptorium Estoniae

    Merritt, Giles

    2009-01-01

    Mõttekoja Friends of Europe peasekretär eelseisvatest Euroopa Parlamendi valimistest, Tšehhist EL-i eesistujamaana, Euroopa Komisjoni vähesest aktiivsusest üleilmse majanduskriisi mõju vähendamisel, protektsionismist, EL-i Venemaa-poliitikast

  4. LEONARDO BENEVOLO et alt. “LA PROYECTACIÓN DE LA CIUDAD MODERNA”

    Directory of Open Access Journals (Sweden)

    Amadeo Ramos Carranza

    2011-05-01

    Full Text Available Este pequeño libro de Benevolo, Melograni y Giura Longo trata de cómo hacer ciudad con la vivienda. Ciudad y vivienda son dos de las grandes líneas argumentales de nuestra contemporaneidad.La progettazione della cittá moderna surge como resultado de una investigación en el marco de la docencia: tres lecciones impartidas a los estudiantes de la Facultad de Arquitectura de Florencia en curso 1966-67. La primera edición data del año 1969 y la primera en versión castellana vería la luz en 1978, incluida en la colección Punto y Línea de la editorial Gustavo Gili. La colección GGReprints recuperó este libro de claros dictados y necesaria consulta.Pasadas varias décadas, la detenida lectura de su corta introducción suscita renovado interés por vincular investigación científica y proyecto de arquitectura. La investigación científica, también en arquitectura, en 1966 acumulaba más de cincuenta años de continuada práctica.El cruce de modelos que se muestra en sus más de 300 páginas, más que un extenso repertorio a modo de guía sobre viviendas, edificios y formas de ciudad y cuyo interés sería relativo, nos ofrece hoy múltiples instantáneas de formas de vida; algunas de ellas permanecen vigentes mientras otras, han sido convenientemente alteradas. Se refiere de esta manera el laboratorio de arquitectura más extenso conocido en constante transformación: el tiempo transcurrido desde la aparición del libro da a esta investigación sobre modelos residenciales una necesaria y conveniente continuidad.

  5. Liner velocity, current, and symmetry measurements on the 32 MA flux compression generator experiment ALT-1

    CERN Document Server

    Clark, D A; Rodríguez, G; Tabaka, L J

    2001-01-01

    Summary form only given, as follows. A flux compression generator based pulse power system, designed, built, and fielded by a Russian team at the All Russian Scientific Research Institute of Experimental Physics (VNIIEF), was used to successfully drive an aluminum liner to velocities greater than 10 km/sec. The experiment objective was to demonstrate performance of a precision liner implosion at Atlas current of 30 MA or greater. Diagnostics to measure liner performance were an essential part of the experiment. An experimental team from Los Alamos National Laboratory (LANL) provided a suite of diagnostics to measure liner performance. Three diagnostics were fielded. 1. a velocity interferometer (VISAR) to continuously measure the liner inner surface velocity from throughout the entire range of travel. 2. Two Faraday rotation devices to measure liner current during the implosion. 3. Sixteen fiber optic impact pins to record liner impact time and provide axial and azimuthal symmetry information. All diagnostics...

  6. Gigantide kokkupõrge: Google lahkub Hiina tsensuuri alt / Heiki Suurkask

    Index Scriptorium Estoniae

    Suurkask, Heiki, 1972-

    2010-01-01

    Google teatas, et Pekingi tsensuurile alistatud veebilehe Google.cn kasutajad juhitakse automaatselt Hongkongi tsenseerimata saidile Google.com.hk. Hiina reageeringust. Teabest, mida hiinlased internetist leida ei tohi

  7. TDC's Pernille Erenbjerg satser alt på et bræt

    DEFF Research Database (Denmark)

    Ørholst, Henrik

    2018-01-01

    Klumme. TDC’s fusion med MTG er en nyskabelse i Europa, men topchefen Pernille Erenbjerg betaler en høj pris, og risikoen for skibbrud er stor.......Klumme. TDC’s fusion med MTG er en nyskabelse i Europa, men topchefen Pernille Erenbjerg betaler en høj pris, og risikoen for skibbrud er stor....

  8. Share price reaction to earnings announcement on the JSE-ALtX: A ...

    African Journals Online (AJOL)

    of testing this concept has been the observation of stock market reaction to corporate ... earnings. Earnings also display management's competitiveness in profitably running a company ... drifts positively in the case of good announcements or negatively in the case of bad ... the gains from trading on annual earnings strategy.

  9. D s Differe lipid solute ential r perox s to sa respon idation alt stre ...

    African Journals Online (AJOL)

    SAM

    weight (RDW plants than. mM NaCl in treated plan content inc. Proline (PR stressed pl increased u at 100 and. NaCl in the tolerant cv. stress mai accumulatio salt toleran. Keywords:A. TRODUCTION inity stress i oductivity in a orie and Sc . 4577-4585, 10. AJB2014.14248 r: 08261044898. 5. 014 n the copyrigh cademicjourn.

  10. The old Jesuit observatory in Graz. (German Title: Die alte Jesuiten-Sternwarte in Graz)

    Science.gov (United States)

    Steinmayr, Johann; Müller, Isolde; Posch, Thomas

    2011-08-01

    We give a brief overview of the development of astronomical research at the University of Graz from the 16th to the 18th century. This period is intimately connected to the activities of the Jesuit Order and to the counter-reformation in Inner Austria (a territory roughly corresponding to today's Styria, Carinthia, Slovenia and the County of Görz in Italy). Since the opening of the University in 1585, several Jesuits achieved distinction as mathematicians, physicists and astronomers in Graz. Among them are Paul Guldin, who corresponded with Johannes Kepler and died in Graz in 1643, as well as Leopold Biwald and Karl Tirnberger. Between 1745 and 1774, the Jesuit University of Graz also had a chair of astronomy and an observatory. The chair and the observatory were well endowed at the beginning, but later on neglected by their former funders and closed down after less than 30 years. Efforts to re-establish an observatory at Graz at the beginning of the 19th century failed. They were successful only towards the end of the 19th century, which is however a period beyond the scope of the present paper.

  11. Een goede keeper heeft alt?d geluk : Sport en het belang van kennis

    NARCIS (Netherlands)

    Tissen, R.J.; Wieldraaijer, E.

    2004-01-01

    Wat hebben sport en kennis met elkaar te maken! Alles. De tijd dat een beetje talent en veel karakter verstonden om de top te bereiken, ligt achter ons. Wie nu in de prijzen wil vallen moet naast aanleg en werklust ook nieuwsgierig zijn, steeds weer op zoek zijn naar nieuwe kennis. Kennis dus van

  12. Changes in alt, ast and alp values of plasma and serum samples ...

    African Journals Online (AJOL)

    Blood samples were obtained from a total of 20 patients that presented with cases of liver malfunction at the Ebonyi State University Teaching Hospital, Abakaliki, Nigeria. The enzyme assays were carried out immediately upon sample collection and separation to obtain the baseline value (BV), and thereafter at specified ...

  13. Notes florístiques de les conques altes dels rius Segre i Llobregat. IV

    OpenAIRE

    Aymerich, Pere

    2016-01-01

    En aquest treball es fan aportacions i precisions a la flora regional de les conques superiors dels rius Segre i Llobregat (Pirineus orientals), en gran part referides a tàxons al·lòctons.Pel que fa a tàxons autòctons, destaquem que Oxybasis rubra és novetat per a la flora de Catalunya, i que per primera vegada s’ofereix informació detallada sobre l’única població coneguda als Pirineus de Myosotis minutiflora. En relació amb els tàxons al·lòctons, és remarcable la detecció de poblacions de Ca...

  14. Notes florístiques de les conques altes dels rius Segre i Llobregat. IV

    OpenAIRE

    Aymerich, Pere

    2016-01-01

    En aquest treball es fan aportacions i precisions a la flora regional de les conques superiors dels rius Segre i Llobregat (Pirineus orientals), en gran part referides a tàxons al·lòctons. Pel que fa a tàxons autòctons, destaquem que Oxybasis rubra és novetat per a la flora de Catalunya, i que per primera vegada s’ofereix informació detallada sobre l’única població coneguda als Pirineus de Myosotis minutiflora. En relació amb els tàxons al·lòctons, és remarcable la detecció de poblacions de C...

  15. Preparation of Poly(MA-alt-α-olefin-C6,8,12,18)

    Indian Academy of Sciences (India)

    in situ generated nanofillers for use as a dual function organonanofiller. DEN˙IZ .... G2 Spirit Biotwin model High Contrast Transmission. Electron .... because solubility is a strict requirement for the NMR studies. ... sess a full condensed silica phase (i.e., corresponding ..... Da Z L, Zhang Q Q, Wu D M, Yang D Y and Qiu F X.

  16. "Gjálvar í tvíningi alt sum er til"

    DEFF Research Database (Denmark)

    Moberg, Bergur Rønne

    2009-01-01

    En beskrivelse af Karsten Hoydals lyriske elementunivers i form af vand-, luft,- ild- og jordmotiver med afsæt i Gaston Bachelards elementpoetik. Der gøres også rede for forfatterskabets litteraturhistoriske placering.......En beskrivelse af Karsten Hoydals lyriske elementunivers i form af vand-, luft,- ild- og jordmotiver med afsæt i Gaston Bachelards elementpoetik. Der gøres også rede for forfatterskabets litteraturhistoriske placering....

  17. Advanced limiter test (ALT-I) in the TEXTOR tokamak - concept and experimental design

    International Nuclear Information System (INIS)

    Conn, R.W.; Grotz, S.P.; Prinja, A.K.

    1983-01-01

    The concept and experimental design of a pump-limiter for the TEXTOR tokamak is described. The module is constructed of stainless steel with a compound curvature head designed to limit the maximum heat flux to 300 W/cm 2 . The head is made of TiC-coated graphite containing a variable aperture slot to admit plasma to a deflector plate for ballistic pumping action. The assembly is actively pumped using Zr-Al getters with an estimated hydrogen pumping speed of 2x10 4 1/s. The aspect ratio of the pump duct and the length of the plasma channel are both variable to permit study of plasma plugging, ballistic scattering, and enhanced gas conduction effects. The module can be moved radially by 10 cm to permit its operation either as the primary or secondary limiter. Major diagnostics include Langmuir and solid state probes, bolometers, infrared thermography, thermocouples, ion gauges, manometers, and a gas mass analyzer. (author)

  18. Ikke alt, der hvæser, hos børn er astma

    DEFF Research Database (Denmark)

    Hermann, Christian

    2000-01-01

    Med udgangspunkt i projektet "Opsporing af astma i 5 års alderen i almen praksis" beskrives asthma i barnealderen som en folkesygdom, der fylder meget i praksis. Det vigtige i tidlig diagnosticering understreges, da man i dag har effektiv medicin og viden om forebyggelse, der om ikke kurerer...... sygdommen så forbedrer trivselen betydeligt. Sygdomsbilledet i almen praksis ligger i grænseområdet til banalt luftvejsbesvær, hvorved det adskiller sig betydeligt fra astma sygdomsbilledet, som det optræder i hospitalssektoren og er beskrevet i lærebøgerne, hvilket er baggrunden for ovennævnte projekt...

  19. CONTRADICTORIALITATEA ÎN CORAPORT CU ALTE PRINCIPII ALE PROCESULUI PENAL

    Directory of Open Access Journals (Sweden)

    Lucia RUSU

    2016-03-01

    Full Text Available În legătură cu reformarea sistemului judiciar şi schimbările intervenite în viaţa social-politică a statului nostru, prin­cipiul contradictorialităţii a obţinut o nouă rezonanţă din considerentul că reforma judiciară şi de drept este legată direct de contradictorialitate. Reforma legii procesual penale trebuie să fie fundamentată pe o temelie teoretică solidă. Contra­dictorialitatea, însă, în calitate de noţiune juridică, este insuficient cercetată în doctrina dreptului procesual penal. La ziua de azi, specialişti notorii în domeniul dreptului procesual penal analizează şi studiază importanţa fundamentelor şi principiilor de bază ale procesului penal şi, în primul rând, contradictorialitatea acestuia. Legea procesual penală a Republicii Moldova cunoaşte o evoluţie şi dezvoltate în sensul democratizării şi lărgirii începuturilor contradictoriale în înfăptuirea justiţiei. Aceasta e şi firesc, deoarece contradictorialitatea are o importanţă enormă pentru întregul sistem al procesului penal, determinând în mare parte statutul juridic şi raporturile dintre participanţii la procesul penal, precum şi relaţiile juridice stabilite între participanţii la acest proces şi instanţa de judecată. CONTRADICTION AND ITS CORRELATION WITH OTHER PRINCIPLES OF THE CRIMINAL PROCEEDINGIn connection with the judiciary system reforming and changes in socio-political life of our state, the adversarial principle has gained a new resonance on the grounds that the judicial and legal reform is directly linked to adversariality. The reform of the criminal procedure law must be based on solid theoretical foundation. However, adversariality, as legal concept, is not enough investigated in the doctrine of the criminal procedure law. Currently, notorious specialists in the field of criminal procedure law examine and study the importance of fundamentals and basic principles of the criminal process and, primarily, its adversariality. The Criminal Procedure Law of the Republic o fMoldovais advancing and developing through democratization and widening of adversariality beginnings in justice rendering. This is natural and, as adversariality has enormous significance for the entire system of criminal proceedings, largely determining the legal status and relations between the participants in criminal proceedings and the legal relationships between the parties to the proceedings and the court.

  20. Management interculturel, altérité, et identités

    CERN Document Server

    Mutabazi, Evalde; Overveck Ottino, Saskia von; Pierre, Philippe

    2014-01-01

    Le management interculturel se fonde sur un effort permanent de remise en question de repères culturels acquis et ressentis comme universels. Ce livre s appuie sur des travaux de recherche et sur des témoignages d expériences pratiques, défend l urgence d un management interculturel au lieu d une gestion de la diversité risquant d assigner des individus à résidence identitaire, et intègre les apports de l ethnopsychanalyse.

  1. Sådan får du frigjort energi til alt det sjove

    DEFF Research Database (Denmark)

    von Bülow, Cecilie

    2016-01-01

    altid energi tilbage til at lave det, man synes er sjovt. Gå i teatret eller i biografen. At gå til foredrag eller måske bare gå på café med veninderne – eller ud og få en øl med gut- terne. Men meget kan ændres med planlæg- ning og ved at tænke anderledes om hvor- dan hverdagen med fibromyalgi......Du kender det fra din egen hverdag. Det kan være svært at finde energien til alle de praktiske gøremål. Vaske tøj, lave mad, gøre rent osv. Når du har fibromyalgi bliver tingene bare mere besværlige, giver smerter og gør dig træt. Og når man bruger alle kræfterne på pligterne, så er der ikke...

  2. Alternative Mixed Assessment Project (ALT.A.: The Mexican E-Learning Experience

    Directory of Open Access Journals (Sweden)

    Mónica A. López-Campos

    2010-11-01

    Full Text Available The aim of this paper is to present an experiment of mixed evaluation (summative/formative of questions formulated by students in a distance-education environment carried out in the Total Quality Management course in the B.S. degree in Industrial Engineering offered by Mexican public universities. Questions generated by students were evaluated using a specially-designed quantitative tool: Matrix Observation of four criteria with binary scoring. The experiment showed: (1 how is it possible to enrich the evaluation process, and formalize students' skills hardly recognizable with traditional forms of assessment; and (2 how the teacher-student interaction can be increased significantly by the technique mixed evaluation of questions in reverse, i.e. by the students.

  3. Når kontakter betyr alt : En studie av bruken av nettverksmediet LinkedIn

    OpenAIRE

    Blaalid, Maren Hyvang

    2012-01-01

    LinkedIn er et av de mest populære sosiale mediene i Norge og tiltrekker seg stadig flere medlemmer. I denne masteroppgaven studerer jeg bruken av LinkedIn for å undersøke hva som er det særegne ved dette nettverksmediet. Jeg har utført en spørreundersøkelse blant 280 brukere for å få innsikt i hvem de er, hvorfor de bruker LinkedIn og hvordan de gjør det. Funnene fra analysen viser at brukerne kjennetegnes ved at de er selvstendige og formålsrasjonelle, som bruker LinkedIn strategisk for å n...

  4. Correction to: Valuch, Tibor. “Following the Life Stories of Participants in the 1956 Hungarian Revolution.” Hungarian Cultural Studies. e-Journal of the American Hungarian Educators Association, Volume 9 (2016 DOI: 10.5195/ahea.2016.253

    Directory of Open Access Journals (Sweden)

    Tibor Valuch

    2017-09-01

    Full Text Available The dates next to the names of two interviewees, Imre Lázár and Zoltán Mervó, were shown incorrectly. The original article can be found via the DOI: http://dox.doi.org/10.5195/ahea.2016.253

  5. Muusikamaailm : Festival "Ultima" Oslos. Kaks juubilari šveitsist. Honeckil juba kaks orkestrit / Priit Kuusk

    Index Scriptorium Estoniae

    Kuusk, Priit, 1938-

    2001-01-01

    Nüüdismuusikafestivalist "Ultima" Oslos. šveitsi muusikategelased Tibor Varga ja Rudolf Kelterborn tähistasid juubelit. Noorel austria dirigendi Manfred Honeck'i juhatada on kaks orkestrit- Rootsi Raadio Sümfooniaorkester ja Oslo Filharmoonia Orkester

  6. Depolymerizable Poly(O-vinyl carbamate-alt-sulfones) as Customizable Macromolecular Scaffolds for Mucosal Drug Delivery.

    Science.gov (United States)

    Kumar, Kaushlendra; Castaño, Eduard Jimenez; Weidner, Andrew R; Yildirim, Adem; Goodwin, Andrew P

    2016-05-17

    Interest in stimulus responsive materials and polymers has grown over the years, having shown great promise in a diverse set of applications. For drug delivery, stimulus-responsive polymers have been shown to encapsulate therapeutic cargo such as small molecule drugs or proteins, deliver them to specific locations in the body, and release them so that they can induce a therapeutic effect in the patient. Most hydrolytically degradable polymers are synthesized via nucleophilic, anionic, or cationic polymerization, which generally requires protection of nucleophilic or protic side chains prior to polymerization. Here, we report the synthesis of novel, alternating copolymers of sulfur dioxide and O-vinyl carbamate monomers that boast excellent functional group tolerance and pH-dependent instability. Alternating copolymers were synthesized containing pendant functionalities such as alcohol, carboxylic acid, ester, and azide without deprotection or post-polymerization modification. The copolymers were then formulated via nanoprecipitation into polymer nanoparticles capable of encapsulating small molecule dyes. The polymer nanoparticles were found to degrade rapidly at pH > 6 and were stable even in highly acidic conditions. Based on this observation, a proof-of-concept study for mucosal delivery was performed in polymer nanoparticles entrapped in a mucus model. At pH 8 the diffusion of encapsulated dye was found to be similar to free dye, while at pH 5 the diffusion coefficient was an order of magnitude lower. Cell viability was retained at 200 µg/mL particles after 24 h incubation. These polymers thus show promise as highly customizable scaffolds for mucosal drug delivery.

  7. Jungbrunnen für alte Meister? Interventionen zeitgenössischer Künstler in Museen alter Kunst

    OpenAIRE

    Keller, Peter

    2015-01-01

    For almost twenty years now, museums of old masters invite contemporary artists to intervene in their rooms. The artists arrange special or permanent exhibitions using their own works and /or works from the collections of the museum. This paper traces the development of these interventions since ca. 1960. The period in question can be divided in two phases. Until the 1990s, contemporary movements such as institutional or museum critique, activism and artistic research shaped the intervention...

  8. Fem sociale medier har »uindskrænket ret« til at misbruge alt dit indhold

    DEFF Research Database (Denmark)

    Nielsen, Jøren Ullits Olai

    2016-01-01

    Ved du, hvor meget kontrol du har over dit indhold på Facebook, YouTube, Snapchat, Instagram og Twitter? Her giver en juraforsker dig det forkromede overblik.......Ved du, hvor meget kontrol du har over dit indhold på Facebook, YouTube, Snapchat, Instagram og Twitter? Her giver en juraforsker dig det forkromede overblik....

  9. Orbiter/carrier separation for the ALT free flight no. 1 reference trajectories. Mission planning, mission analysis and software formulation

    Science.gov (United States)

    Glenn, G. M.

    1976-01-01

    Details of the generation of the separation trajectories are discussed. The analysis culminated in definition of separation trajectories between physical separation and orbiter/carrier vortex clearance. Specifications, assumptions and analytical approach used to generate the separation trajectories are presented. Results of the analytical approach are evaluated. Conclusions and recommendations are summarized. Supporting references are listed.

  10. The small hydropower plant in the old river Aare in Niedergoesgen, Switzerland; Kleinwasserkraftwerk Ballyschwelle, alte Aare, Niedergoesgen. Vorprojekt

    Energy Technology Data Exchange (ETDEWEB)

    Eichenberger, P.

    2007-07-15

    This preliminary project for the Swiss Federal Office of Energy (SFOE) presents a project which proposes the construction of a new small hydro plant in Niedergoesgen/Gretzenbach, Switzerland, that is to make use of the waters of the old river Aare. The project proposes the construction of a new, 350 kW plant at the site of an existing sill across the old river that originally formed part of a water-power installation given up in 1917. The existing parts of the old installation are described and the legal situation concerning water rights and land ownership are examined. Three variants for a new installation are described. Technical figures and energy-production estimates for a new installation are discussed. Ecological aspects are examined, as are the recreational aspects of the river at this location. Cost estimates and economic viability are discussed.

  11. Yoga tõuseb tuhast: hoidke alt India, USA ja Araabia Ühendemiraadid ! / Toivo Tänavsuu

    Index Scriptorium Estoniae

    Tänavsuu, Toivo

    2010-01-01

    2008. a. pankrotistunud tarkvarafirma Yoga IB kavatseb taas naasta infotehnoloogia turule. Firma poolt väljatöötatud tarkvaralahenduste abil on võimalik ruumides kontrollida kliimatingimusi, valgustust, liikumist ja turvasüsteeme

  12. Release of hand burn contracture: comparing the ALT perforator flap with the gracilis free flap with split skin graft.

    Science.gov (United States)

    Misani, M; Zirak, C; Hau, Lê Thua Trung; De Mey, A; Boeckx, W

    2013-08-01

    The use of microsurgery in the management of burn sequelae is not a new idea. According to the properties of various types of free flaps different goals can be achieved or various additional procedures have to be combined. We report the comparison of two different free flaps on a single patient for reconstruction of both upper extremities for burn sequelae. A 1-year-old child sustained severe burns on both hands, arms and thorax and was initially only treated conservatively. This resulted in severe contractures. At the age of 4-years a free gracilis flap was selected for reconstruction of his left hand and a free anterolateral thigh flap for the right hand. We noticed a better functional and esthetic result for the gracilis flap associated with a shorter operative time and a minor donor site morbidity. The intraoperative technique and time, postoperative complications, functional and esthetic results and donor site morbidities were studied in the two types of flaps chosen. A review of literature was also performed. Our experience reported a better success of the gracilis muscle flap covered with a split skin graft compared to the anterolateral thigh flap in the reconstruction of hand function after severe burn sequelae. Copyright © 2013 Elsevier Ltd and ISBI. All rights reserved.

  13. Daya Bunuh Hand Sanitizer Berbahan Aktif Alkohol 59% dalam Kemasan Setelah Penggunaan Berulang terhadap Angka Lempeng Total (ALT

    Directory of Open Access Journals (Sweden)

    Isnaeni Walidah

    2014-03-01

    Full Text Available Kebersihan merupakan tahap awal untuk menjaga pola hidup sehat dan terhindar dari penyakit. Pencegahan penyebaran penyakit salah satunya adalah dengan mencuci tangan menggunakan antiseptik hand sanitizer.  Hand sanitizer berbahan aktif alkohol 40 – 80%  mampu menghambat pertumbuhan bakteri. Tetapi pemakaian hand  sanitizer yang tidak langsung habis akan mempengaruhi kualitas hand sanitizer Penggunaan berulang hand sanitizer akan mempengaruhi kemampuan bahan aktif dalam membunuh kuman karena alkohol sebagai bahan aktif pada hand sanitizer memiliki sifat yang mudah menguap. Tujuan penelitian untuk mengetahui daya bunuh hand sanitizer berbahan aktif alkohol 59% dalam kemasan setelah penggunaan berulang terhadap angka lempeng total. Metode  penelitian analitik observasional, menggunakan 10 responden yang diuji angka lempeng total pada tangan setelah penggunaan berulang hand sanitizer dari volume 50 ml sampai dengan ± 25 ml dan dari volume ± 25 ml sampai dengan ± 12,5 ml. Hasil penelitian menunjukkan daya bunuh hand sanitizer berbahan aktif alkohol 59% dalam kemasan setelah penggunaan berulang dari volume 50 ml sampai volume ± 25 ml sebesar  21,38%. Sedangkan daya bunuh hand sanitizer pada penggunaan berulang  hand sanitizer dari volume ± 25 ml sampai dengan volume ± 12,5 ml sebesar 15,83%. Ada pengaruh penggunaan berulang hand sanitizer berbahan aktif alkohol 59% dalam kemasan terhadap jumlah angka lempeng total

  14. Daya Bunuh Hand Sanitizer Berbahan Aktif Alkohol 59% dalam Kemasan Setelah Penggunaan Berulang terhadap Angka Lempeng Total (ALT)

    OpenAIRE

    Isnaeni Walidah; Bambang Supriyanta; Sujono Sujono

    2014-01-01

    Kebersihan merupakan tahap awal untuk menjaga pola hidup sehat dan terhindar dari penyakit. Pencegahan penyebaran penyakit salah satunya adalah dengan mencuci tangan menggunakan antiseptik hand sanitizer.  Hand sanitizer berbahan aktif alkohol 40 – 80%  mampu menghambat pertumbuhan bakteri. Tetapi pemakaian hand  sanitizer yang tidak langsung habis akan mempengaruhi kualitas hand sanitizer Penggunaan berulang hand sanitizer akan mempengaruhi kemampuan bahan aktif dalam membunuh...

  15. Women's labour and economic globalisation: a participatory workshop created by Alternative Women in Development (Alt-WID).

    Science.gov (United States)

    Barton, C; Nazombei, E

    2000-03-01

    This article describes the aims, methods, materials and topics used in a participatory workshop created by Alternative Women in Development. The organization aims to bridge the gaps in analyzing human rights and economic justice in both North and South from a feminist perspective through a workshop. This workshop considers the varied roles that women play in the global economy and features a series of anecdotes to illustrate the diverse ways in which globalization affects women in all regions worldwide. The workshop runs for a minimum of 3 hours and is structured as follows: introduction; plenary: identifying the human rights of the women; small-group work, plenary: building a group analysis and discussion of alternatives to the existing policies; and individual and plenary evaluations. Furthermore, four anecdotes used at the workshop are presented. Among the outcomes of the workshop included the identification of the problem causes and development of strategies for action.

  16. Deciphering the Role of Alternative Non-Homologous End Joining (Alt-NHEJ) DNA Repair in Breast Cancer

    Science.gov (United States)

    2017-12-01

    consecutive TTAGGG repeats. To detect rare reads containing fusion junctions, we exploited the novel sequence arrangement created by the ligation of the 39G...journal.pgen.1001005 (2010). 14 van Kregten, M. et al. T-DNA integration in plants results from polymerase-theta-mediated DNA repair. Nat Plants 2

  17. Preliminary temperature Accelerated Life Test (ALT) on III-V commercial concentrator triple-junction solar cells

    OpenAIRE

    Espinet González, Pilar; Algora del Valle, Carlos; Orlando Carrillo, Vincenzo; Nuñez Mendoza, Neftali; Vázquez López, Manuel; Bautista Villares, Jesus; Xiugang, He; Barrutia Poncela, Laura; Rey-Stolle Prado, Ignacio; Araki, Kenji

    2012-01-01

    A quantitative temperature accelerated life test on sixty GaInP/GaInAs/Ge triple-junction commercial concentrator solar cells is being carried out. The final objective of this experiment is to evaluate the reliability, warranty period, and failure mechanism of high concentration solar cells in a moderate period of time. The acceleration of the degradation is realized by subjecting the solar cells at temperatures markedly higher than the nominal working temperature under a concentrator Three e...

  18. Una officina lapidària en la comarca de l'Alt Palància

    OpenAIRE

    Arasa i Gil, Ferran

    1992-01-01

    A partir de un número significativo de inscripciones halladas en diversas poblaciones de la comarca del Alto Palancia (Castellón) que presentan rasgos comunes, se plantea la existencia de una oficina epigráfica en la misma.

  19. Poly(methyl vinyl ether-alt-maleic acid)-functionalized porous silicon nanoparticles for enhanced stability and cellular internalization.

    Science.gov (United States)

    Shahbazi, Mohammad-Ali; Almeida, Patrick V; Mäkilä, Ermei; Correia, Alexandra; Ferreira, Mónica P A; Kaasalainen, Martti; Salonen, Jarno; Hirvonen, Jouni; Santos, Hélder A

    2014-03-01

    Currently, developing a stable nanocarrier with high cellular internalization and low toxicity is a key bottleneck in nanomedicine. Here, we have developed a successful method to covalently conjugate poly(methyl vinyl ether-co-maleic acid) (PMVE-MA) copolymer on the surface of (3-aminopropyl)triethoxysilane-functionalized thermally carbonized porous silicon nanoparticles (APSTCPSi NPs), forming a surface negatively charged nanovehicle with unique properties. This polymer conjugated NPs could modify surface smoothness, charge, and hydrophilicity of the developed NPs, leading to considerable improvement in the colloidal and plasma stabilities via enhanced suspensibility and charge repulsion. Furthermore, despite the surface negative charge of the polymer-conjugated NPs, the cellular internalization was increased in both MDA-MB-231 and MCF-7 breast cancer cells. These results provide a proof-of-concept evidence that such polymer-based PSi nanocomposite can be extensively used as a promising candidate for intracellular drug delivery. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  20. Apprendre le latin ou l'expérience de l'altérité radicale

    Directory of Open Access Journals (Sweden)

    Dr Geneviève Chovrelat

    2006-06-01

    Full Text Available La littérature latine nous offre une relation d'intimité dans un jeu métaphorique qui permet aussi de nous mesurer à l'Autre dans un double rapport au réel et à l'imaginaire, le sien et le nôtre. Et Carthage, par la conjugaison de l'Histoire et de la grammaire, file une métaphore à valeur d'oxymore, fondation - destruction modulée par de très nombreux écrivains, Flaubert, Kateb Yassine... Essentielle dans l'apprentissage d'une langue morte, la littérature est la démarche individuelle vers l'Autre. Face à l'uniformisation du mode de vie et de pensée, le latin, langue vivace, permet de garder l'héritage du patrimoine universel.

  1. Removal of Copper ions from aqueous solutions using polymer derivations of poly (styrene-alt-maleic anhydride

    Directory of Open Access Journals (Sweden)

    Naser Samadi

    2017-06-01

    Full Text Available In this study chelating resins have been considered to be suitable materials for the recovery of Copper (II ions in water treatments. Furthermore, these modified resins were reacted with 1,2-diaminoethane in the presence of ultrasonic irradiation for the preparation of a tridimensional chelating resin on the Nano scale for the recovery of Copper (II ions from aqueous solutions. This method which is used for removing and determining Copper (II ions using copolymers derived resins of poly (styrene-alternative-maleic anhydride (SMA and atomic absorption spectroscopy. The method is simple, sensitive, inexpensive and fast. The various parameters such as pH, contact time, concentrations of metal ions, mass of resin, and agitation speed were investigated on adsorption effect. The adsorption behavior of Copper (II ions were investigated by the synthesis of chelating resins at various pHs. The prepared resins showed a good tendency for removing the selected metal ions from aqueous solution, even at an acidic pH. Also, the prepared resins were examined for the removal of Copper (II ions from real samples such as industrial wastewater and were shown to be very efficient at adsorption in the cases of Copper (II ions. The pseudo-first-order, pseudo-second-order, and intra-particle diffusion kinetics equations were used for modeling of adsorption data and it was shown that pseudo-second-order kinetic equation could best describe the adsorption kinetics. The intra-particle diffusion study revealed that external diffusion might be involved in this case. The resins were characterized by Fourier transform infrared spectroscopy, scanning electron microscopy, and X-ray diffraction analysis.

  2. Effet des terres rares sur la structure et l'altération des verres borosilicatés

    OpenAIRE

    Molières , Estelle

    2012-01-01

    This work is related to the question of the geological deep repository of high-level waste glass. These wastes include fission products and minor actinides, elements which can be simulated by rare earths. As new glass compositions could enable increased rare earth concentrations, it is crucial to know and understand rare earth impact on glass structure on the one hand, and on glass alteration kinetics or their incorporation into an altered layer. This work studied simplified borosilicate glas...

  3. Discrete geometry in honor of W. Kuperberg's 60th birthday

    CERN Document Server

    Bezdek, Andras

    2003-01-01

    Transversal lines to lines and intervals, Jorge L. Arocha, Javier Bracho, and Luis Montejano; on a shortest path problem of G. Fejes, Toth Donald R. Baggett and Andras Bezdek; a short survey of (r,q)-structures, Vojtech Balint; lattice points on the boundary of the integer hull, Imre Barany and Karoly Boroczky, Jr; the Erdos-Szekeres problem for planar points in arbitrary position, Tibor Bisztriczky and Gabor Fejes Toth, separation in totally-sewn 4-polytopes, Tibor Bisztriczky and Deborah Oliveros, on a class of equifacetted polytopes, Gerd Blind and Roswitha Blind; chessboard Ramsey numbers,

  4. Monitoring illicit psychostimulants and related health issues

    NARCIS (Netherlands)

    Brunt, T.M.

    2012-01-01

    Tibor Brunt onderzocht het Drug Informatie en Monitoring Systeem (DIMS), een landelijk netwerk dat de samenstelling van drugs als ecstasy en cocaïne analyseert. Die middelen zijn van gebruikers zelf afkomstig. Het is een effectieve manier om riskante stoffen te detecteren die aan de drugs worden

  5. Lahkunud 1999

    Index Scriptorium Estoniae

    2000-01-01

    Ilmar Torn (10. I), Leopold Ennosaar (21. I), Voldemar Vaga (23. II), Ilmar Laasi (15. VIII), Voldemar Peil (17. X), Ludvig Kruusmaa (7. XII), Aksel Vallaste (13. XII), Aldo van Eyck (1919-14. I 1999), Bernard Buffet (1928-4. X 1999), Tibor Kalman (1950-5. V 1999).

  6. Characterization of Charge-Carrier Transport in Semicrystalline Polymers: Electronic Couplings, Site Energies, and Charge-Carrier Dynamics in Poly(bithiophene- alt -thienothiophene) [PBTTT

    KAUST Repository

    Poelking, Carl

    2013-01-31

    We establish a link between the microscopic ordering and the charge-transport parameters for a highly crystalline polymeric organic semiconductor, poly(2,5-bis(3-tetradecylthiophen-2-yl)thieno[3,2-b]thiophene) (PBTTT). We find that the nematic and dynamic order parameters of the conjugated backbones, as well as their separation, evolve linearly with temperature, while the side-chain dynamic order parameter and backbone paracrystallinity change abruptly upon the (also experimentally observed) melting of the side chains around 400 K. The distribution of site energies follows the behavior of the backbone paracrystallinity and can be treated as static on the time scale of a single-charge transfer reaction. On the contrary, the electronic couplings between adjacent backbones are insensitive to side-chain melting and vary on a much faster time scale. The hole mobility, calculated after time-averaging of the electronic couplings, reproduces well the value measured in a short-channel thin-film transistor. The results underline that to secure efficient charge transport in lamellar arrangements of conjugated polymers: (i) the electronic couplings should present high average values and fast dynamics, and (ii) the energetic disorder (paracrystallinity) should be small. © 2013 American Chemical Society.

  7. poten~,'9fCoQs~~Weua"ds ~ ~'Alt~~*tive',fo~ W~ewater

    African Journals Online (AJOL)

    Constructed Wetbnd' (HSSFCW) SYstem' in polishing pre-ire~ied ... applied in thereclatfiation of wastewater for irrigation to bene.fit the society in terns .... existing Vpward Anaerbbi,c Sludge Blanket From the design perspecti\\re. the problem of.

  8. Poly[(arylene ethynylene)-alt-(arylene vinylene)]s based on anthanthrone and its derivatives: synthesis and photophysical, electrochemical, electroluminescent, and photovoltaic properties

    Czech Academy of Sciences Publication Activity Database

    John, S. V.; Cimrová, Věra; Ulbricht, C.; Pokorná, Veronika; Růžička, Aleš; Giguére, J.-B.; Lafleur-Lambert, A.; Morin, J.-F.; Iwuoha, E.; Egbe, D. A. M.

    2017-01-01

    Roč. 50, č. 21 (2017), s. 8357-8371 ISSN 0024-9297 R&D Projects: GA ČR(CZ) GA13-26542S Institutional support: RVO:61389013 Keywords : polycyclic aromatic compounds * anthanthrones and anthanthrone derivatives * electroluminescence Subject RIV: BM - Solid Matter Physics ; Magnetism OBOR OECD: Condensed matter physics (including formerly solid state physics, supercond.) Impact factor: 5.835, year: 2016

  9. Virtueller Medizinischer Campus Graz: eine e-Learning Umgebung wird 5 Jahre alt / Virtual Medical Campus Graz: an e-learning environment has its 5 year-anniversary

    Directory of Open Access Journals (Sweden)

    Reibnegger, Gilbert

    2007-12-01

    Full Text Available Parallel with the initiation of an integrated curriculum at the Medical University of Graz a virtual learning environment was implemented, designated as Virtual Medical Campus (VMC. Several financial support projects made the development of the VMC and its enhancements possible. Learning objects are granular and strictly equipped with a set of metadata conforming the SCORM 2004 2nd edition-standard and are therefore reusable and exchangeable with other study courses or e-Learning-systems. Simple usability allows authors the intuitive creation of content, which may be enriched with interactive and tutorial systems using several built in authoring tools like web-based-training or a Virtual Microscope. In 2005 more than 3300 students applied for human medicine at the Medical University of Graz and it was decided to give a virtual term with a selection process at the end of it.More than 1 million accesses to learning objects and 257,000 web-based-trainings were handled without a single breakdown. This unique interim solution of a virtual term demonstrated the capacity of the VMC-system and the organisational possibility to intercept rushes of application using e-Learning. In the meanwhile the VMC Graz provides 13 study courses at four universities in two different European countries and two international postgraduate programs. The technical development aims at Web 3.0 – “Semantic Web” and the further expansion of co-operations is a present and future strategy.

  10. Simple synthesis, photophysics, and electroluminescent properties of poly[2,7-bis(4-tert-butylstyryl)fluorene-9,9-diyl-alt-alkane-.alpha.,.omega.-diyl

    Czech Academy of Sciences Publication Activity Database

    Mikroyannidis, J. A.; Barberis, V. P.; Výprachtický, Drahomír; Cimrová, Věra

    2007-01-01

    Roč. 45, č. 5 (2007), s. 809-821 ISSN 0887-624X R&D Projects: GA MŠk(CZ) 1M06031; GA AV ČR IAA4050409; GA ČR GA203/04/1372 Institutional research plan: CEZ:AV0Z40500505 Keywords : distyrylfluorene * electrochemical properties * electroluminescence Subject RIV: CD - Macromolecular Chemistry Impact factor: 3.529, year: 2007

  11. Hydraulique des unités d'interfluves et de bas-fond tourbeux: un exemple en zone de socle altéré (Madagascar)

    Science.gov (United States)

    Grillot, J. C.; Dussarrat, B.

    1992-07-01

    The hydrodynamics of the groundwater system of the upland granito-gneissic plateau of Madagascar is governed by the structure of the underlying aquifer. In the alteritic interfluves, the aquifer has two layers; the peat aquifer is multilayered. Groundwater levels and spring discharges observed over 3 successive years distinguish between two different types of hydraulic behaviour. (1) Under the interfluves, unconfined conditions are found in allochtonous weathered material, and semi-confined conditions in the autochtonous weathered basement. These two systems are separated by a semi-permeable clay layer. The first system responds rapidly to rainfall (approximately 15 days) whereas the second system responds more slowly (approximately 3 months). This leads to a vertical flux between the two aquifers, the direction of which depends on the season; at the beginning of the wet season the flux is downwards, but during the later part of the season the direction reverses. (2) In the low-lying regions, where sequences are superimposed, the direction of the vertical flow changes several times over a year. At the beginning of the wet season the flux is downwards, it reverses at the end of the season. A downwards flux is then observed towards the second part of the dry season. Such behaviour is only observed in the lowest third of the catchment where permeable silts take the place of less permeable peat. This pattern of fluxes suggests a close relationship between surface water and groundwater regimes, and has a major influence on the individual water balances of the two systems.

  12. Influence of Side Chain Position on the Electrical Properties of Organic Solar Cells Based on Dithienylbenzothiadiazole-alt-phenylene Conjugated Polymers

    DEFF Research Database (Denmark)

    Livi, Francesco; Zawacka, Natalia Klaudia; Angmo, Dechan

    2015-01-01

    backbone for polymer solar cells. All the polymers were roll slot die coated under ambient conditions on flexible ITO-free plastic substrates to give inverted polymer solar cell devices with an upscaled active area of 1 cm2. The best characteristics were found for the polymer carrying alkoxy side chains...... showed excellent performance under constant illumination and high temperature (exhibiting stable photovoltaic properties even after 670 h under conditions similar to ISOS-L-2 lifetime protocol). This makes P7 a good candidate for further upscaling and device optimization. The photovoltaic performance...

  13. Diabetik Ayak Sağaltımında Vakum Destekli Kapama (VAC) Metodu ve Debridmanın Birlikte Etkinliği

    OpenAIRE

    Fırat, Cemal; Aytekin, Ahmet Hamdi; Fırat, Serkan ErbaturCemal; Aytekin, Ahmet Hamdi; Erbatur, Serkan

    2015-01-01

    Amaç: Diabetik ayak ülserleri periferik nöropati, vasküler yetmezlik ve immün sistem bozukluklarından oluşan kısır döngünün sonucu olup enfeksiyon ve doku kayıplarına neden olmaktadır. Bu yıkıcı süreç cerrahi onarım seçeneklerini oldukça kısıtlamakta ve greftle onarım seçeneğini öne çıkarmaktadır. Greftlerin başarısı enfeksiyondan arındırılmış yeterli granülasyon dokusunun varlığına bağlıdır. Vakum yardımlı yara kapama sistemi (VAC) tedavisi bu iki etkiyi aynı anda sağlamada oldukça etkili ve...

  14. Alt-right Claims that would put the Soviets to shame : The alleged conspiracies of conservative reformers like count Coudenhove-Kalergi and the Bilderberg Group

    NARCIS (Netherlands)

    de Bruin, R.

    2017-01-01

    It is striking that many of today’s conspiracy theories under the umbrella of “cultural Marxism” attribute imagined conspiracy theories retroactively to conservative or even reactionary organisations, groups and individuals of the past. People that actually strived for reform in order to preserve:

  15. Alte Thesen neu gelesen: Perspektiven kritischer Stadtforschung. Kommentar zu Hartmut Häußermann & Walter Siebels „Thesen zur Soziologie der Stadt“

    Directory of Open Access Journals (Sweden)

    Carsten Keller

    2013-07-01

    Full Text Available [Dieser Artikel ist Teil einer Debatte] Der Text „Thesen zur Soziologie der Stadt“ scheint mir besonders in den abschließend formulierten Perspektiven, die Hartmut Häußermann und Walter Siebel unter der Überschrift „Aufgaben einer kritischen Soziologie der Stadt“ formulieren, nach wie vor lesenswert und aktuell zu sein. Drei Perspektiven werden hier aufgezeigt: erstens eine Wissenschafts- und Ideologiekritik, zweitens eine empirisch orientierte Zustandsbeschreibung städtischer Strukturen und von Stadtentwicklung sowie drittens eine Analyse der staatlichen Stadtpolitik. Diese drei abschließenden Perspektiven möchte ich im Folgenden kommentieren. Es wird mithin keine immanente Auseinandersetzung mit dem gesamten Text und weiteren Arbeiten der beiden Autoren angestrebt. Es hätte mich zwar durchaus gereizt, die Entwicklung der Arbeiten von Häußermann und Siebel vor dem Hintergrund dieses frühen, emphatisch formulierten Textes zu reflektieren. Vielleicht auch wegen der persönlichen Bekanntschaft mit Häußermann, den ich als Projekt- und Dissertationsbetreuer an der Humboldt-Universität kennenlernte, erschien mir eine solche Zugangsweise zu den „Thesen“ durchaus naheliegend. [...

  16. Are porosity and permeability seismic structural parameter? An old idea is presented and scrutinized; Sind Porositaet und Permeabilitaet seismische Strukturparameter? Eine alte Idee kurz vorgestellt und hinterfragt

    Energy Technology Data Exchange (ETDEWEB)

    Fertig, J. [Technische Univ. Clausthal, Clausthal-Zellerfeld (Germany). Inst. fuer Geophysik

    2008-10-23

    The exploration of hydrocarbons is confronted with the penetration into ever larger depths with increasingly more unfavorable reservoir characteristics. That means lower porosities and permeabilities. The geometry of a tectonic formation is a substantial size for the gap formation. It is expected that the observable curvature of a rock formation stands in direct connection with porosity and permeability of the rock. Under this aspect, the behaviour of a rock formation is examined at the demand above the yield strength by means of theoretical approaches from fracture mechanics. The author of the available contribution comes to the result: Secondary porosity is directly proportional to the curvature of the formation. In contrast to this, the secondary permeability is proportional to the third power of the curvature of the formation.

  17. Analyse quantitative et modélisation biomécanique de l’altération de l’équilibre durant le vieillissement

    OpenAIRE

    Amabile , Celia

    2016-01-01

    Aging of the global population challenges scientific community in finding ways to live longer, but also in better condition. Falling of the elderly is known to be the start of a vicious cycle leading to loss of autonomy, involving great costs for the society as well as for the patient. Falling is the consequence of the loss of an efficient balance involving skeleton, muscles and cognitive capacities. The objective of this PhD was to search for early changes leading to pathological aging, in o...

  18. Characterization of Charge-Carrier Transport in Semicrystalline Polymers: Electronic Couplings, Site Energies, and Charge-Carrier Dynamics in Poly(bithiophene- alt -thienothiophene) [PBTTT

    KAUST Repository

    Poelking, Carl; Cho, Eunkyung; Malafeev, Alexander; Ivanov, Viktor; Kremer, Kurt; Risko, Chad; Bré das, Jean-Luc; Andrienko, Denis

    2013-01-01

    We establish a link between the microscopic ordering and the charge-transport parameters for a highly crystalline polymeric organic semiconductor, poly(2,5-bis(3-tetradecylthiophen-2-yl)thieno[3,2-b]thiophene) (PBTTT). We find that the nematic and dynamic order parameters of the conjugated backbones, as well as their separation, evolve linearly with temperature, while the side-chain dynamic order parameter and backbone paracrystallinity change abruptly upon the (also experimentally observed) melting of the side chains around 400 K. The distribution of site energies follows the behavior of the backbone paracrystallinity and can be treated as static on the time scale of a single-charge transfer reaction. On the contrary, the electronic couplings between adjacent backbones are insensitive to side-chain melting and vary on a much faster time scale. The hole mobility, calculated after time-averaging of the electronic couplings, reproduces well the value measured in a short-channel thin-film transistor. The results underline that to secure efficient charge transport in lamellar arrangements of conjugated polymers: (i) the electronic couplings should present high average values and fast dynamics, and (ii) the energetic disorder (paracrystallinity) should be small. © 2013 American Chemical Society.

  19. Resonance energy transfer from quinolinone modified polystyrene-block-poly(styrene-alt-maleic anhydride) copolymer to terbium(III) metal ions

    Czech Academy of Sciences Publication Activity Database

    Výprachtický, Drahomír; Mikeš, F.; Lokaj, Jan; Pokorná, Veronika; Cimrová, Věra

    2015-01-01

    Roč. 160, April (2015), s. 27-34 ISSN 0022-2313 R&D Projects: GA ČR GAP106/12/0827; GA ČR(CZ) GA13-26542S Institutional support: RVO:61389013 Keywords : energy transfer * terbium luminescence * quinolinone donor Subject RIV: CD - Macromolecular Chemistry Impact factor: 2.693, year: 2015

  20. Hg0 and HgCl2 Reference Gas Standards: NIST Traceability and Comparability (And EPA ALT Methods for Hg and HCl )

    Science.gov (United States)

    EPA and NIST have collaborated to establish the necessary procedures for establishing the required NIST traceability of commercially-provided Hg0 and HgCl2 reference generators. This presentation will discuss the approach of a joint EPA/NIST study to accurately quantify the tru...

  1. The old with the die. A contribution to metaphysics of quantum mechanics; Der Alte mit dem Wuerfel. Ein Beitrag zur Metaphysik der Quantenmechanik

    Energy Technology Data Exchange (ETDEWEB)

    Ijjas, Anna

    2011-07-01

    Since the rise of quantum mechanics also their ideological implications and consequences were discussed. Meanwhile still scarcely a metaphysical problem exists, which was not supposedly solved under calling on quantum theory. Anna Ijjas inquires the usual practice and developes a new model of the assignment of quantum mechanics and metaphysics. She discusses both the physical foundations and the classical philosophical controversies, before she draws consequencies for the relation determination of brain and consciousness, the problem of freedom of will, as well as for the question of the influence of God in the world.

  2. Cartographie numérique en géologie de surface. Application aux altérites à silex de l'Ouest du bassin de Paris

    OpenAIRE

    Quesnel , Florence

    1997-01-01

    Thèse publiée. Document du BRGM, 263, 268 p et 160 p d'annexes.; The compilation of data from 50 geological maps (1:50,000 scale), 2,500 boreholes and their combination in the creation of thematic maps using G.I.S. software, has enabled the anatomy of the flint alterites (termed RS, residu à silex or "clay-with-flints") of the western Paris Basin to be established. Geostatistical treatment of the thickness variable of superficial plateau formations (RS + plateau loams + Cenozoic residuals) an...

  3. UV and γ-ray resistance of poly(N-methylmaleimide-alt-isobutene) and poly(diisopropyl fumarate) as transparent polymer films

    Science.gov (United States)

    Imaizumi, Ryota; Furuta, Masakazu; Okamura, Haruyuki; Matsumoto, Akikazu

    2017-09-01

    UV and γ-ray resistance of transparent polymers obtained by radical polymerization of maleic and fumaric acid derivatives, i.e., an alternating copolymer of N-methylmaleimide and isobutene (PMI) and poly(diisopropyl fumarate) (PDiPF), was investigated. Transmittance in UV and visible regions of these polymers were examined after UV irradiation and compared with the results for poly(methyl methacrylate) (PMMA) and polycarbonate (PC) as conventional transparent polymers. The order of stability toward UV irradiation was PMMA≈PDiPF>PMI>>PC, deduced from changes in the transmittance of 380 nm light. Tensile mechanical properties, such as elastic modulus, maximum strength, and elongation values of PMI, PDiPF, and PMMA were also investigated after UV and γ-radiation. UV irradiation induced the side chain scission of PMI and PDiPF via Norrish I type reaction as well as crosslinking by combination between formed polymer radicals, leading to deterioration in their optical and mechanical properties. γ-radiation induced significant changes in molecular weight and mechanical properties of the polymers. In conclusion, PMI exhibited unchanged mechanical properties and PDiPF maintained its high transparency under various irradiation conditions.

  4. Novel poly(triphenylamine-alt-fluorene) with asymmetric hexaphenylbenzene and pyrene moieties: synthesis, fluorescence, flexible near-infrared electrochromic devices and theoretical investigation

    KAUST Repository

    Wang, Po-I.; Shie, Wan-Ru; Jiang, Jyh-Chiang; Li, Lain-Jong; Liaw, Der-Jang

    2016-01-01

    . The conjugated polymer had a weight-average molecular weight of 5.8 × 104 g mol-1 with a polydispersity index of 2.5 characterized by gel permeation chromatography (GPC). HPBPYFL6 showed good solubility in common organic solvents such as NMP, THF, toluene

  5. Effects of Packing Structure on the Optoelectronic and Charge Transport Properties in Poly(9,9-di-n-octylfluorene-alt-benzothiadiazole)

    DEFF Research Database (Denmark)

    Donley, C.L.; Zaumseil, J.; Andreasen, Jens Wenzel

    2005-01-01

    on the optoelectronic and charge transport properties of these films. A model based on quantum chemical calculations, wide-angle X-ray scattering, atomic force microscopy, Raman spectroscopy, photoluminescence, and electron mobility measurements was developed to describe the restructuring of the polymer film...

  6. Physical Analysis of the Complex Rye (Secale cereale L.) Alt4 Aluminium (Aluminum) Tolerance Locus Using a Whole-Genome BAC Library of Rye cv. Blanco

    Science.gov (United States)

    Rye is a diploid crop species with many outstanding qualities, and is also important as a source of new traits for wheat and triticale improvement. Here we describe a BAC library of rye cv. Blanco, representing a valuable resource for rye molecular genetic studies. The library provides a 6 × genome ...

  7. Successful performances of the EU-AltTF sample, a large size Nb{sub 3}Sn cable-in-conduit conductor with rectangular geometry

    Energy Technology Data Exchange (ETDEWEB)

    Della Corte, A; Corato, V; Di Zenobio, A; Fiamozzi Zignani, C; Muzzi, L; Polli, G M; Reccia, L; Turtu, S [Associazione EURATOM-ENEA sulla Fusione, Via E Fermi 45, 00044 Frascati, Rome (Italy); Bruzzone, P [EPFL-CRPP, Fusion Technology, 5232 Villigen PSI (Switzerland); Salpietro, E [European Fusion Development Agreement, Close Support Unit, Boltzmannstrasse 2, 85748 Garching (Germany); Vostner, A, E-mail: antonio.dellacorte@enea.i [Fusion for Energy, c/ Josep Pla 2, Edificio B3, 08019 Barcelona (Spain)

    2010-04-15

    One of the design features which yet offers interesting margins for performance optimization of cable-in-conduit conductors (CICCs), is their geometry. For relatively small size Nb{sub 3}Sn CICCs, operating at high electromagnetic pressure, such as those for the EDIPO project, it has been experimentally shown that a design based on a rectangular layout with higher aspect ratio leads to the best performance, especially in terms of degradation with electromagnetic loads. To extend this analysis to larger size Nb{sub 3}Sn CICCs, we manufactured and tested, in the SULTAN facility, an ITER toroidal field (TF) cable, inserted into a thick stainless steel tube and then compacted to a high aspect ratio rectangular shape. Besides establishing a new record in Nb{sub 3}Sn CICC performances for ITER TF type cables, the very good test results confirmed that the conductor properties improve not only by lowering the void fraction and raising the cable twist pitch, as already shown during the ITER TFPRO and the EDIPO test campaigns, but also by the proper optimization of the conductor shape with respect to the electromagnetic force distribution. The sample manufacturing steps, along with the main test results, are presented here.

  8. Au prisme de l’altérité, les orthodoxes de Beyrouth au début du xix esiècle

    Directory of Open Access Journals (Sweden)

    May Davie

    2012-01-01

    Full Text Available La construction sociale des orthodoxes de Beyrouth, au début du xixe siècle, s’effectue autant dans le cadre de la communauté qu’à travers un réseau de relations et d’obligations économiques et sociales extérieures. Cet article, par une approche d’histoire urbaine, contredit les thèses du cloisonnement confessionnel.

  9. Tsiganes, stéréotypes et idéal type. Une approche wébérienne de l’altérité

    Directory of Open Access Journals (Sweden)

    Martin Olivera

    2010-04-01

    Full Text Available « [Discuter] à perte de vue et d’opinion en opinion des gens de valeurs aussi inégales, mais traitées également pour l’occasion, que Durkheim d’une part, et Max Weber et tous les Scheller du monde de l’autre […] n’ayant aucune valeur heuristique, n’a aucun intérêt scientifique. »Lettre de M. Mauss à G. Gurvitch, 1936. On trouve dans la famille lexicale des types deux frères ennemis quasiment jumeaux qui semblent pourtant évoluer dans des univers bien distincts. Tandis que le stéréotype relèv...

  10. Kampf der Generationen oder Solidarität zwischen Jung und Alt? Das österreichische Pflegesystem im europäischen Vergleich

    Directory of Open Access Journals (Sweden)

    Andrea E. Schmidt

    2014-03-01

    Full Text Available Die Arbeit geht der Frage nach, wie sich das österreichische System der Langzeitbetreuung älterer Menschen mit Augenmerk auf die nachhaltige Solidarität zwischen Generationen u.a. im Vergleich mit anderen europäischen Ländern gestaltet. Besonderes Augenmerk wird dabei auf Finanzierungs-, Versorgungs- und Governance-Strukturen gelegt, sowie auf den Vergleich mit anderen sozialpolitischen Bereichen (Familienleistungen, Kinderbetreuung. Österreich hat im internationalen Vergleich ein relativ großzügiges System der öffentlichen Unterstützung älterer Menschen, das stark auf Geldleistungen aufbaut. Dies gilt auch für die Langzeitbetreuung, wo eine große Anzahl pflegebedürftiger Menschen erreicht wird, diese aber pro Kopf eher wenig erhalten. Die Pflegeleistungen werden aus allgemeinen Steuermitteln sowie Kostenbeiträgen von NutzerInnen finanziert, was bedeutet, dass die Finanzierung primär über die Besteuerung von Arbeitseinkommen erfolgt. Unterschiedliche Kostenbeitrags- und Regressregelungen auf Bundesländerebene führen zudem zu großen Differenzen in der finanziellen und faktischen Verantwortung von Familien, insbesondere jüngerer Generationen, die Pflege und Betreuung pflegebedürftiger Angehöriger sicherzustellen. Es folgt, dass die Einführung vermögensbezogener „Pflegesteuern“ zu mehr Ausgewogenheit in den solidarischen Elementen des Pflegesystems beitragen könnte – nicht nur aus Generationensicht. Der flächendeckende Ausbau von Pflege- und Betreuungsdiensten und bundesweit einheitliche Regelungen zu privaten Kostenbeiträgen stellen zudem eine Voraussetzung dafür dar, dass Solidarität zwischen den Generationen unabhängig von sozialer Schicht und Wohnort beurteilt werden kann.

  11. New roof for an old building. PV system on a historical single-family home; Altes Haus kraftvoll eingedeckt. PV-Anlage auf historischem Einfamilienhaus

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    2009-03-15

    For hundreds of years, slated roofs and walls were the characteristic feature of the Thuringian-Franconian boundary region, where the ''Schieferstrasse'' - the road of historical houses with slated roofs and walls - is a major tourist attraction. Today, owners of buildings are interested in technologies orientated towards the future. After restoration of a single-family home at Lehestenbuilt in 1650, modern solar modules installed on the roof and combined with traditionally-looking aluminium roof tiles by Prefa make an aesthetically pleasing picture. (orig.)

  12. Les altérations des vins par les bacteries acétiques et les bactéries lactiques

    Directory of Open Access Journals (Sweden)

    Suzanne Lafon-Lafourcade

    1984-03-01

    Full Text Available Acetic acid and lactic acid bacteria were present at all stages of wine making. A lower pH and a highter ethanol concentration limit the risks of alteration. During the conservation, a low temperature, good use of S02 and frequent checkings ensure control of bacterial growth and metabolism.

  13. Apports des phyllosilicates dans la différenciation entre altération hypogène et altération supergène dans le basalte triasique du Moyen Atlas (Maroc)Contribution of phyllosilicates to distinguish between hypogene alteration and weathering in Triassic basalt from Middle Atlas (Morocco)

    Science.gov (United States)

    Dekayir, Abdelilah; Danot, Michel; Allali, Nabil

    2002-09-01

    Triassic basalt of the Middle Atlas has been subject to metamorphic transformation then weathering. Occurrence in both metabasalt and saprolite of ubiquitous clay minerals, such as smectite and mixed layers chlorite-smectite, makes it difficult to distinguish between the two alteration facies and explains the interest of complementary sources of information. In the Bhallil weathering profile, petrographical and mineralogical analyses of primary igneous minerals and their alteration products coupled with Fe oxidation state determination in clay fractions allow to identify three alteration facies: ( i) metamorphic basalt, where iron occurs mainly as the ferrous form; ( ii) the lower part of saprolite, where iron is partially oxidized to its ferric form; ( iii) the upper part of saprolite, where iron is completely oxidized. To cite this article: A. Dekayir et al., C. R. Geoscience 334 (2002) 877-884.

  14. Pengaruh Tipografi pada Era Massimo Vignelli terhadap Tipografi Michael Bierut

    Directory of Open Access Journals (Sweden)

    Irwan Harnoko

    2011-10-01

    Full Text Available Massimo Vignelli is a senior graphic designer lived in New York, as a vocal modernism against post-modernism. His statement firmly opposing post-modernism in several occasions: interview in Helvetica the movie, typeradio, talkshow, and some articles in Looking Closer or AIGA Journal. Graphic design works of Massimo Vignelli reflected his characteristic, which is firmly choosing typeface. Typefaces of Vignelly are around 5 typefaces: Bodoni, Helvetica, Times Roman, Century, and Futura. The article uses formal analysis method. The writers collected materials about Michael Bierut, Massimo VIgnelli and Tibor Kalman from books and websites. The writers compare the typeface opinion of Massimo Vignelli (modernism designer, Michael Bierut designer (transition era designer from modernism to post-modernism, and Tibor Kalman (a designer in A Century of Graphic Design, as the influencer of Bierut’s betrayal over Vignelli. 

  15. Osteogenic capacity of nanocrystalline bone cement in a weight-bearing defect at the ovine tibial metaphysis

    OpenAIRE

    Harms, Christoph; Helms,; Taschner,; Stratos,; Ignatius,; Gerber,Thomas; Lenz,; Rammelt,; Vollmar,Brigitte; Mittlmeier,Thomas

    2012-01-01

    Christoph Harms,1 Kai Helms,1 Tibor Taschner,1 Ioannis Stratos,1 Anita Ignatius,5 Thomas Gerber,2 Solvig Lenz,3 Stefan Rammelt,6 Brigitte Vollmar,4 Thomas Mittlmeier11Department of Trauma and Reconstructive Surgery, 2Department for Materials Research and Nanostructures, Institute for Physics, 3Department of Oral and Maxillofacial Plastic Surgery, 4Institute for Experimental Surgery, University of Rostock, Rostock, 5Institute of Orthopaedic Research and Biomechanics, University of Ulm, Ulm, 6C...

  16. Axe cerveau-intestin et contrôle de la prise alimentaire : exemple d'altérations chez un modèle animal de schizophrénie

    OpenAIRE

    Voinot , Florian

    2012-01-01

    The brain-gut axis refers to the bidirectional interaction between the gut and the brain. Although leptin, a hormone released from fat tissue, is involved in the brain-gut axis control, its mechanism of action in the enteric nervous system has not been studied so far. Nowadays, brain-gut axis dysfunctions are supposed to be in close connection with schizophrenia. Therefore, the goals of this work were to determine 1) the effects of leptin on rat enteric nervous system neurotransmission and 2)...

  17. Indicadores químicos de combustión en un hogar del Paleolítico Medio del yacimiento de Mediona I (Alt Penedès, Barcelona

    Directory of Open Access Journals (Sweden)

    Lozano, Joan Miquel

    1995-12-01

    Full Text Available Organical chemical analysis of archaeological soils is a recently developed technique, which considerably increases the information available from ancient remains. The present study gives an example of their capabilities in the reconstruction of the paleoenvironment in the Middle Paleolithic Mediona 1 site. Pyrogenic chemical-markers have been identified from the study of the lipid aromatic fraction in a previously excavated combustion area. These compounds have made it possible to recognize hearths which are not clearly defined by other means.

    La aplicación del análisis químico orgánico a muestras arqueológicas es una técnica de desarrollo reciente. El estudio de la fracción lipídica (eso es, la fracción de materia extraíble mediante disolventes orgánicos de restos sedimentarios en yacimientos permite recuperar una información inaccesible a otras técnicas de identificación aplicadas a la Arqueología. Este artículo describe de forma comparativa la fracción aromática del sedimento en el interior y en el exterior de un área de combustión en un yacimiento paleolítico previamente excavado. Asimismo, presenta el análisis de indicadores químicos pirogénicos con una técnica de gran potencial para la identificación de áreas de combustión en yacimientos donde éstos no están claramente definidos (simples manchas sin carbones, agrupación de piedras sin evidencias externas de termo alteración, etc., siempre comparándolas con muestras de sedimento no termo alterado del mismo nivel arqueológico.

  18. Théâtre en langue des signes, théâtre de l’altérité ? Sourds, entendants et interculturalité autour de l’International Visual Theatre

    Directory of Open Access Journals (Sweden)

    Olivier Schetrit

    2013-11-01

    Founded in 1976, the IVT (International Visual Theatre is today defined as a cultural crossroads, a place of exchanges and discoveries for deaf and hearing people. From the search of a theatrical and artistic culture specific to the deaf to its distribution in the public space, from the reception of its bilingual shows to the teaching of sign language pursued by the IVT, we propose here to study the complex back and forth relations between the mirrored otherness that deaf and hearing identities represent to each other. Thus, from the point of views of a deaf researcher and a hearing researcher, on the one hand, we will explore the role of the IVT in the (rediscovery of deaf identity through modes of expression such as deaf theater, dance and choreography, “chansigne” and “visual music”. On the other hand, we will reflect on common issues between the stage and the classroom, these two facets aiming at promoting sign language and deaf culture among the hearing. We will then analyze and explain how the appropriation of the “empty space” (Brook, 1968 provided by the stage has turned it into a (inter cultural space where learning other languages and cultures implies self-discovery through others.

  19. Bulanık Analitik Hiyerarşi Süreci ile Uygun Altı Sigma Metodolojisinin Seçimi(The Selection of Appropriate Six Sigma Methodology by Using Fuzzy Analytical Hierarchy Process

    Directory of Open Access Journals (Sweden)

    Çiğdem SOFYALIOĞLU

    2009-01-01

    Full Text Available Six sigma is considered as a business strategy that depends on the continuous improvement approach that tries to eliminate the process variability and aims to decrease the scrap in business processes by using statistical tools and techniques. In this study, first the differences between Six Sigma Improvement Model and Design for Six Sigma will be given and then the proper methodology for the business in order to achieve its goals will be determined by using fuzzy AHP which is one of the multicriteria decision making techniques.

  20. An 18-yr long (1993–2011 snow and meteorological dataset from a mid-altitude mountain site (Col de Porte, France, 1325 m alt. for driving and evaluating snowpack models

    Directory of Open Access Journals (Sweden)

    S. Morin

    2012-07-01

    Full Text Available A quality-controlled snow and meteorological dataset spanning the period 1 August 1993–31 July 2011 is presented, originating from the experimental station Col de Porte (1325 m altitude, Chartreuse range, France. Emphasis is placed on meteorological data relevant to the observation and modelling of the seasonal snowpack. In-situ driving data, at the hourly resolution, consist of measurements of air temperature, relative humidity, windspeed, incoming short-wave and long-wave radiation, precipitation rate partitioned between snow- and rainfall, with a focus on the snow-dominated season. Meteorological data for the three summer months (generally from 10 June to 20 September, when the continuity of the field record is not warranted, are taken from a local meteorological reanalysis (SAFRAN, in order to provide a continuous and consistent gap-free record. Data relevant to snowpack properties are provided at the daily (snow depth, snow water equivalent, runoff and albedo and hourly (snow depth, albedo, runoff, surface temperature, soil temperature time resolution. Internal snowpack information is provided from weekly manual snowpit observations (mostly consisting in penetration resistance, snow type, snow temperature and density profiles and from a hourly record of temperature and height of vertically free ''settling'' disks. This dataset has been partially used in the past to assist in developing snowpack models and is presented here comprehensively for the purpose of multi-year model performance assessment. The data is placed on the PANGAEA repository (http://dx.doi.org/10.1594/PANGAEA.774249 as well as on the public ftp server ftp://ftp-cnrm.meteo.fr/pub-cencdp/.

  1. Etude de l’altération de la calcarénite des monuments de Rabat : Influence de la Pollution Atmosphérique et des Aérosols Marins

    Directory of Open Access Journals (Sweden)

    Zaouia Nouhad

    2014-04-01

    Le but du présent travail est de constituer une base de données pour orienter les recherches ultérieures sur la problématique de la conservation du patrimoine bâti et optimiser le choix des matériaux de remplacement, tout en prenant en compte tous les mécanismes et démarches nécessaires pour une meilleure protection dans lecadre d’un développement urbain en perpétuelle expansion.

  2. The Impact of 10 weeks of Aerobic Exercise and Supplementation of Green Tea on Lipid Profile, Insulin Resistance and Liver Enzymes (GGT, ALT, AST in Obese Diabetic Women (type 2

    Directory of Open Access Journals (Sweden)

    M Izadi Ghahfarokhi

    2015-05-01

    Conclusions: Green tea supplements with aerobic training were effective in controlling obesity and type 2 diabetes. By increasing the duration of the exercise and supplementation, it may find desirable results on serum cholesterol and triglycerides.

  3. Al-Khalfiyyah al-Farâdigmâiyyah lî Azmat al-Bîah wa al-T awajjuh al-’Ilmiy al-Kauniy ‘Inda Said al-Nursi

    Directory of Open Access Journals (Sweden)

    Kadeer Jann Atton

    2014-05-01

    Full Text Available Suatu kemiskinan atau kemakmuran dapat memiliki dampak negatif terhadap lingkungan sehingga memicu kesadaran pemerintah dan akademisi untuk mengambil kebijakan guna memperbaiki orientasi pembangunan dengan mengarahkannya pada kelestarian lingkungan. Kerusakan ekologis dalam berbagai bentuk seperti polusi, kerusakan tanah, erosi, penggundulan hutan, pemanasan global, hujan asam, punahnya spesies liar, gerakan limbah berbahaya yang diakibatkan oleh aktivitas manusia telah terjadi dalam skala massif dan global. Maka, diperlukan paradigma pembangunan berkelanjutan yang dapat memenuhi kebutuhan saat ini tanpa merusak kemampuan generasi- generasi mendatang untuk memenuhi kebutuhan mereka sendiri. Pembangunan yang memanusiakan manusia, dan tidak benci terhadap teknologi modern. Pembangunan yang tidak rmerusak manusia, dan memarginalkan kontribusi mereka. Segala sesuatunya absah, sepanjang memungkinkan manusia untuk memegang kendali yang lebih baik atas nasibnya sendiri; sepanjang hal itu tidak memperbudak manusia, menimbulkan perpecahan, membuat manusia kehilangan keseimbangan mental dan kesehatan fisik, serta menciptakan disharmoni dalam masyarakat sehingga terwujud peradaban Islam global universal. Peradaban Islam universal dengan semua karakteristik dan identitasnya akan mampu mengubah peradaban Barat, secara positif konstruktif. Karena, landasan utama peradaban Islam adalah kebenaran dan bukan kekuatan, sedangkan parameter kebenaran adalah keadilan dan keseimbangan, dengan memberdayakan pemanfaatan lingkungan secara holistik terpadu. Hal itu dikarenakan tujuan utama peradaban adalah keutamaan dan manfaat yang sebesar-besarnya bagi pengembangan dan kemajuan umat.

  4. Constructing in the monument. Respecting the Old and mark the New. Cost-reliable planning during building upon existing structures; Bauen im Denkmal. Altes achten und Neues kenntlich machen. Kostensicher planen beim Bauen im Bestand

    Energy Technology Data Exchange (ETDEWEB)

    Schneider-Sorger, Roswitha [ORCA Software GmbH, Rosenheim (Germany)

    2011-07-01

    The revitalization of historically protected real estate is a passion of the owners - the family Werndl (Rosenheim, Federal Republic of Germany). In the case of the Old spinning mill in the Kolbenmotor near Rosenheim a whole district was arranged new. The highest premise of the planning team Quest Architekten GBR (Rosenheim, Federal Republic of Germany) was to respect and receive the rough charm of the building stock. This also becomes clear considering the two-storey Batteur building of 1862 being a component of the energy centre of the spinning mill. Once cotton was cleaned, now shops and gastronomy are in the ground floor as well as practices and office units in the upper floor.

  5. Film afişleri tasarımında göstergeler: Prof. Yurdaer Altıntaş'ın film afişleri çözümleme örneği

    OpenAIRE

    Tığlı -Tuzcu, İlkay

    2012-01-01

    Göstergebilim yaşamın her alanında görebileceğimiz, çeşitli anlamlı bütünleri ele alarak, insanların birbirleriyle iletişim kurmalarını sağlayan gösterge birimlerini inceleyen, anlamlandıran ve sınıflandıran bilim dalı olarak tanımlanmaktadır. Göstergeler ifade ettikleri ?şeyleri? doğrudan okuyucuya ilettikleri gibi, yanamlarla ya da örtük bir biçimde göndermeler yaparak da iletişimi sağlarlar. Dilbilimsel öğeleri ve görsel içerikleri ile iletişimi gerçekleştiren afişler birer grafik tasarım ...

  6. TÜRKİYE İÇİN İŞ-AİLE DENGESİ ÖLÇEĞİNİN ALT BOYUTLARI VE BELİRLEYİCİLERİ

    OpenAIRE

    GÜLER, Hüseyin; GÜLER, Ebru ÖZGÜR

    2015-01-01

    Bu çalışmanın amacı İş-Aile Dengesi Ölçeğinin (Work-Family Balance Scale, WFBS)faktör yapısını ortaya çıkarmak ve bu ölçeğin Türkiye’deki geçerlilik ve güvenilirliğinibelirlemektir. Ölçek, istatistiki bölge kavramında kullanılmakta olan, 1. Düzeydeki 12İstatistiki Bölgede yaşayan 682 vatandaştan oluşan bir örneklem üzerinde uygulanmıştır.Orijinal halinde 26 ifade bulunan “İş-Aile Kısıtları” ve “İş-Aile Kazanımları” ölçeği, işailedengesini ölçmek amacıyla kullanılan uygun bir ölçektir. Daha ön...

  7. Estrategias de (reapropiación urbana y disputa territorial en la conformación de los barrios alteños El Porvenir I y 16 de Julio (Bolivia, 1985-2012

    Directory of Open Access Journals (Sweden)

    Mariela Paula Diaz

    2015-01-01

    Full Text Available Generalmente la ciudad de El Alto (Bolivia es analizada como un núcleo urbano homogéneo. Eneste artículo se analiza la existencia de ejemplos de desarrollo urbano desigual y combinado. Elobjetivo principal es abordar las estrategias de acceso al hábitat y la (reapropiación del territoriourbano por parte de los migrantes aymaras residentes en el barrio periférico El Porvenir I y enel barrio céntrico 16 de Julio. Se presta atención a la disputa con los diversos actores sociales queparticipan en la dinámica de la construcción barrial: los loteadores informales y el Estado duranteel periodo 1985-2012.Para llevar a cabo este estudio se aplicó una metodología cualitativa que incluyó entrevistas semiestructuradasa la población migrante y a los informantes-clave y observación no participante,incorporando datos de fuentes secundarias.

  8. Human papillomavirus testing for triage of women with cytologic evidence of low-grade squamous intraepithelial lesions: baseline data from a randomized trial. The Atypical Squamous Cells of Undetermined Significance/Low-Grade Squamous Intraepithelial Lesions Triage Study (ALTS) Group.

    Science.gov (United States)

    2000-03-01

    Human papillomavirus (HPV) infections appear to be central to the development of cervical cancer. This study addresses the question of whether testing women who have low-grade squamous intraepithelial lesions (LSILs) of the uterine cervix for HPV DNA is useful as a triage strategy. Four clinical centers in different areas of the United States participated in a randomized clinical trial of the use of HPV DNA testing in women with cytologic evidence of atypical squamous cells of undetermined significance (ASCUS) or LSIL. The study sample in this article consists only of women who had LSIL at enrollment. Within 6 months of an LSIL diagnosis (based on a Pap smear read by a community-based cytopathologist), women who were 18 years of age or older completed a standardized questionnaire and underwent a pelvic examination that included collection of cervical specimens for HPV DNA testing by Hybrid Capture II (HCII)(R) assay. Among the 642 women referred with LSIL who had analyzable test results, the mean chronologic age and age at first coitus were similar among the four clinical centers, despite the centers' ethnic and geographic diversity. Overall, HPV DNA was detected in cervical samples from 532 (82.9%) of the 642 women (95% confidence interval = 79.7%-85.7%). This high frequency of HPV positivity was confirmed by polymerase chain reaction (PCR) assays in a subset of 210 paired specimens tested by HCII and PCR (81.4% were positive by both methods). Because a very high percentage of women with an LSIL diagnosis from Pap smears are positive for HPV DNA by HCII testing, there is limited potential for this assay to direct decisions about the clinical management of women with LSIL. The role of HPV testing in the management of women with ASCUS is still under study.

  9. Das Licht am Ende des Tunnels: Motivationsstrukturen fur den Deutschunterricht Reflexionen uber ein altes und stets neues Problem (The Light at the End of the Tunnel: Structures for Motivating German Teaching. Reflections on an Old and Continually New Problem).

    Science.gov (United States)

    Classen, Albrecht

    2001-01-01

    Argues that despite the decline in enrollments in German at elementary and secondary schools and colleges and universities, there is reason to hope that interest can be invigorated. Suggests that there are easy instructional methods and materials for developing a new motivation in learning the language. (Author/VWL)

  10. Mirror-symmetry-breaking in poly[(9,9-di-n-octylfluorenyl- 2,7-diyl)-alt-biphenyl] (PF8P2) is susceptible to terpene chirality, achiral solvents, and mechanical stirring.

    Science.gov (United States)

    Fujiki, Michiya; Kawagoe, Yoshifumi; Nakano, Yoko; Nakao, Ayako

    2013-06-17

    Solvent chirality transfer of (S)-/(R)-limonenes allows the instant generation of optically active PF8P2 aggregates with distinct circular dichroism (CD)/circularly polarized luminescence (CPL) amplitudes with a high quantum yield of 16-20%. The present paper also reports subtle mirror-symmetry-breaking effects in CD-/CPL-amplitude and sign, CD/UV-vis spectral wavelengths, and photodynamics of the aggregates, though the reasons for the anomaly are unsolved. However, these photophysical properties depend on (i) the chemical natures of chiral and achiral molecules when used in solvent quantity, (ii) clockwise and counterclockwise stirring operations, and (iii) the order of addition of limonene and methanol to the chloroform solution.

  11. Mirror-Symmetry-Breaking in Poly[(9,9-di-n-octylfluorenyl-2,7-diyl-alt-biphenyl] (PF8P2 is Susceptible to Terpene Chirality, Achiral Solvents, and Mechanical Stirring

    Directory of Open Access Journals (Sweden)

    Ayako Nakao

    2013-06-01

    Full Text Available Solvent chirality transfer of (S-/(R-limonenes allows the instant generation of optically active PF8P2 aggregates with distinct circular dichroism (CD/circularly polarized luminescence (CPL amplitudes with a high quantum yield of 16–20%. The present paper also reports subtle mirror-symmetry-breaking effects in CD-/CPL-amplitude and sign, CD/UV-vis spectral wavelengths, and photodynamics of the aggregates, though the reasons for the anomaly are unsolved. However, these photophysical properties depend on (i the chemical natures of chiral and achiral molecules when used in solvent quantity, (ii clockwise and counterclockwise stirring operations, and (iii the order of addition of limonene and methanol to the chloroform solution.

  12. The New Economy Macroeconomics : The Late Golden “Age of Diminished Expectations”? = Yeni Ekonomi Makroekonomisi : Son Altın “Azalan Bekleyişler” Çağı?

    Directory of Open Access Journals (Sweden)

    Bilal SAVAŞ

    2004-01-01

    Full Text Available The remarkable economic success of the US in the late 1990s led many economists to talk about a 'New Economy', according to which technological advances had brought on a higher sustained level of productivity growth that allowed faster economic growth with less inflation, and very low unemployment. But given the events since 2000-the long, steep stock market downturn, the falloff in business investment and the subsequent recession-many questions arose based on whether anything in the New Economy view is valid. This essay provides a detailed overview of the main issues, many of them closely linked to the rise of the Internet.

  13. Söke Ovasında (Aydın) yeni bir kültür bitkisi: Yer Kirazı/Altın Çilek (Physalis peruviana)

    OpenAIRE

    Özdemir, Yasemin; Günal, Nurten

    2018-01-01

    Cape gooseberry (Physalis peruviana) is an economically valuable species of Physalis in the family of Solanaceae. Native to the tropical South America, Cape Gooseberry then spread to tropical, subtropical, and sometimes mild climate zones. Physalis peruviana is a plant that highly needs heat, sun light and moisture, and that does not withstand low temperature and strong winds. It is not so much selective in terms of soil.Cape Gooseberry/Golden Strawberry was first grown in the town Bağarası i...

  14. Estudio de la comunidad de Cystoseira mediterránea en dos localidades de la península del cabo de Creus (Alt Empardà, Nordeste de España

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    Rull Lluch, Jordi

    1990-05-01

    Full Text Available A survey has been carried out of the Cystoseira mediterranea community from eight samples seasonally collected in two localities of the cape Creus peninsula (N. E. Spain .
    The results obtained are related to the environmental conditions and they are compared with those obtained by other authors.

    Se ha realizado un estudio de la comunidad de Cystoseira mediterranea a partir de ocho muestras recolectadas estacionalmente en dos localidades de la península del cabo de Creus (nordeste de España. Los resultados obtenidos se comentan en relación con las condiciones ambientales y se comparan con los obtenidos por otros autores.

  15. Microwave-assisted and conventional synthesis, photophysics and electroluminescence of poly(9,9-dihexadecylfluorene-2,7-diyl-alt-2,2′-bithiophene-5,5′-diyl)

    Czech Academy of Sciences Publication Activity Database

    Dzhabarov, Vagif; Výprachtický, Drahomír; Cimrová, Věra

    2018-01-01

    Roč. 98, January (2018), s. 420-429 ISSN 0014-3057 R&D Projects: GA ČR(CZ) GA13-26542S Institutional support: RVO:61389013 Keywords : dialkylfluorene-bithiophene copolymers * microwave-assisted heating * Suzuki coupling Subject RIV: BM - Solid Matter Physics ; Magnetism OBOR OECD: Condensed matter physics (including formerly solid state physics, supercond.) Impact factor: 3.531, year: 2016

  16. Recognized and new problems of power generation from waste wood according to the new EEG of 2004; Alte und neue Probleme der Altholzverstromung nach der EEG-Novelle 2004

    Energy Technology Data Exchange (ETDEWEB)

    Anger, C. [Avocado Rechtsanwaelte, Koeln (Germany)

    2005-10-01

    Power generation from waste wood according to the EEG (Renewables Act), even in the modified version of 2004, raises complex legal problems under EU law. The contribution discusses these problems and presents important information on the legal boundary conditions of power generation from waste wood. (orig.)

  17. Le corps abstrait d’une princesse nuwaubienne : l’extra-terrestre comme figure de l’altérité dans l’œuvre de Juliana Huxtable

    OpenAIRE

    Schicharin, Luc

    2017-01-01

    Cet article procède d’une étude esthétique et sémiologique des autoportraits de Juliana Huxtable en princesse nuwaubienne afin de comprendre les enjeux de l’usage artistique de la figure de l’extra-terrestre dans son travail plastique. À partir d’une analyse des œuvres et des entretiens de l’artiste, nous établissons que l’autoportrait extra-terrestre d’Huxtable est, en premier lieu, une exploration philosophique et artistique de la notion de race, considérée comme une corporéité abstraite, m...

  18. Zor İyileşen Alt Ekstremite Yaralarının Tedavisinde Negatif Basınçlı Yara Tedavi Yönteminin Etkinliği ve Sonuçları

    OpenAIRE

    Aygün, Hayati; Çakar, Albert; Atilla, Atıl; Irlayıcı, Bilgin; Aytekin, Mahmut; Ağır, İsmail; İslam, Cihangir

    2014-01-01

    Aim: The chronic infected wounds are commonly encountered in the orthopedic practice and occur due to several etiological factors. They are responsible for serious morbidity and mortality. Regardless of the etiology, the underlying factors at these wounds are healing problems and predisposition to infection due to microvascular insufficiency. There are several methods for the treatment of these wounds. One of them is vacuum assisted closure systems (VAC) or negative pressure wound therapy (NP...

  19. 77 FR 62618 - Designation of Two (2) Entities Pursuant to Executive Order 13224 of September 23, 2001...

    Science.gov (United States)

    2012-10-15

    ...; P.O. Box 13-7692, Beirut, Lebanon; Email Address [email protected]hotmail.com ; alt. Email Address [email protected] ; alt. Email Address [email protected]hotmail.com ; alt. Email Address [email protected

  20. Global Tuberculosis Report 2016

    Science.gov (United States)

    ... Alt+0 Navigation Alt+1 Content Alt+2 Tuberculosis (TB) Menu Tuberculosis Data and statistics Regional Framework Resources Meetings and events Global tuberculosis report 2017 WHO has published a global TB ...

  1. Evolutionary Diversification of Alanine Transaminases in Yeast: Catabolic Specialization and Biosynthetic Redundancy

    Directory of Open Access Journals (Sweden)

    Ximena Escalera-Fanjul

    2017-06-01

    Full Text Available Gene duplication is one of the major evolutionary mechanisms providing raw material for the generation of genes with new or modified functions. The yeast Saccharomyces cerevisiae originated after an allopolyploidization event, which involved mating between two different ancestral yeast species. ScALT1 and ScALT2 codify proteins with 65% identity, which were proposed to be paralogous alanine transaminases. Further analysis of their physiological role showed that while ScALT1 encodes an alanine transaminase which constitutes the main pathway for alanine biosynthesis and the sole pathway for alanine catabolism, ScAlt2 does not display alanine transaminase activity and is not involved in alanine metabolism. Moreover, phylogenetic studies have suggested that ScALT1 and ScALT2 come from each one of the two parental strains which gave rise to the ancestral hybrid. The present work has been aimed to the understanding of the properties of the ancestral type Lacchancea kluyveri LkALT1 and Kluyveromyces lactis KlALT1, alanine transaminases in order to better understand the ScALT1 and ScALT2 evolutionary history. These ancestral -type species were chosen since they harbor ALT1 genes, which are related to ScALT2. Presented results show that, although LkALT1 and KlALT1 constitute ScALT1 orthologous genes, encoding alanine transaminases, both yeasts display LkAlt1 and KlAlt1 independent alanine transaminase activity and additional unidentified alanine biosynthetic and catabolic pathway(s. Furthermore, phenotypic analysis of null mutants uncovered the fact that KlAlt1 and LkAlt1 have an additional role, not related to alanine metabolism but is necessary to achieve wild type growth rate. Our study shows that the ancestral alanine transaminase function has been retained by the ScALT1 encoded enzyme, which has specialized its catabolic character, while losing the alanine independent role observed in the ancestral type enzymes. The fact that ScAlt2 conserves 64

  2. Etude de la diagraphie neutron du granite de Beauvoir. Effet neutron des altérations et de la matrice du granite. Calibration granite. Porosité totale à l'eau et porosité neutron Analysis of the Beauvoir Granite Neutron Log. Neutron Effect of Alterations and of the Granite Matrix. Granite Calibration. Total Water Porosity and Neutron Porosity

    Directory of Open Access Journals (Sweden)

    Galle C.

    2006-11-01

    Full Text Available Cet article rend compte des travaux effectués sur la porosité du granite de Beauvoir (Sondage GPF 1 d'Echassières, Massif Central français. L'objectif de notre étude est de pouvoir obtenir des valeurs représentatives de la saturation en eau (porosité totale à l'eau n du granite de Beauvoir à partir des mesures de porosité neutron PorositéN (diagraphie neutron BRGM sans avoir recours aux mesures sur carottes. Notre démarche est expérimentale et nous avons tenté d'approfondir certains problèmes liés à l'utilisation de la diagraphie neutron dans une roche granitique. Deux facteurs principaux conditionnent la réponse neutron : la concentration en hydrogène de la formation (eau libre et eau de constitution de certains minéraux et la présence d'éléments absorbeurs à forte section de capture comme le gadolinium, le cadmium, le bore, . . . et dans le cas du granite de Beauvoir, le lithium. A partir des mesures de porosité totale à l'eau n sur carottes, des essais de pertes au feu sur poudre qui nous permettent de déterminer la porosité neutron liée à l'eau de constitution PorositéN(OH- et des analyses chimiques avec lesquelles nous évaluons la porosité neutron thermique PorositéN(ox (Programme SNUPAR, Schlumberger liée à la capture neutronique, nous reconstituons la porosité neutron totale PorositéNR du granite de Beauvoir. Pour 7 échantillons caractéristiques du granite de Beauvoir, nous réalisons grâce à ces résultats une nouvelle calibration du taux de comptage neutron initial corrigé du gradient thermique et de l'effet de trou. Grâce à cette opération, il est possible de déterminer, pour les échantillons traités, la porosité neutron du granite avec une calibration granite (PorositéNg et non calcaire (PorositéNc. La connaissance de l'effet neutron de la matrice nous permet enfin d'évaluer la teneur en eau du granite (porosité totale à l'eau et de comparer celle-ci avec la porosité mesurée sur carottes (n. Nous montrons que, pour le granite de Beauvoir, l'effet neutron de la matrice est important (en moyenne proche de 7% et ne peut être négligé lorsque l'on mesure des porosités voisines de 0,5% sur carottes. La calibration de l'outil neutron dans le granite et non pas dans des calcaires est d'autre part capitale quant à la précision quantitative des résultats. This article describes the research done on the Beauvoir granite (Echassières GPF 1 borehole, French Massif Central range. The aim of this project was to obtain representative values of the water saturation (n total free water porosity of the Beauvoir granite from PorosityN neutron porosity (BRGM neutron log. The exact knowledge of the porosity of a crystalline block is effectively fundamental to determine its possibilities for being used as a waste storage site. With this goal, neutron logging provides indispensable information concerning the characterization of a porous medium. Our procedure was experimental, and we tried to go more deeply into various problems linked to the use of neutron logging in a granitic rock. Two main factors governed the neutron response : (i the hydrogen concentration of the formation (free water and combined water of various minerals and (ii the presence of absorber elements with a large capture cross-section such as gadolinium, cadmium, boron as well as lithium for the Beauvoir granite. After measuring the Beauvoir granite n total (free water porosity on core samples, we evaluated the combined water content of each sample tested on the basis of fire loss tests on rock powder at 900°C. From the hydrogen atoms volumic concentration, we determined a hydrogen index that we directly converted into the PorosityN(OH- neutron porosity, (by definition, pure water at 20°C has a hydrogen index of 1 which is equivalent to a 100% porosity. For the Beauvoir granite, the matrix combined water represents an average neutron porosity (Table 1 of about 4%. In the second phase, we used chemical analysis to evaluate the PorosityN(ox thermal neutron porosity linked to neutron capture (Schlumberger's Nuclear Parameter Code, SNUPAR. A calibration curve (Fig. 1 between the (Sigmamac macroscopic capture cross-section and the PorosityN neutron porosity enabled us to determine the PorosityN(ox neutron capture porosity for all samples. The macroscopic capture cross-section of the Beauvoir granite, compared to other rocks (Table 2, is very high, about 86 cu. For the Beauvoir granite, the neutron capture porosity was estimated at about 2. 7% (Table 4. The lithium, with Li2O contents varying from 0. 3 to 1. 7%, is the one element which accounts for 85% of this effect (Table 3. Although the response of a neutron tool is not linear for low porosities (especially lower than 5% and although in some cases the neutron effect of the matrix highly depends on the hydrogen index (close imbrication of neutron slowing and capture phenomena, we restored the PorosityNR total neutron porosity of the Beauvoir granite by stacking n, PorosityN(OH- and PorosityN(ox linearly. This porosity is 9% on the average. For this granite, the PorosityNma neutron matrix effect (PorosityNma = PorosityN(OH- + PorosityN(ox is significant and accounts for 75% of the PorosityNR total neutron porosity corresponding to about 7%. This porosity thus cannot be neglected if the objective is to obtain representative water content values of the granite from neutron porosity log. This is why the second part of our project took up the problem of calibrating neutron tool for analyzing a granitic formation. For the Beauvoir granite, the neutron porosity data were obtained from standard calibration in limestone blocks. As the neutron effect of the granite matrix was not negligible, we performed our own calibration using seven granite samples with a perfectly well-known total neutron porosity (free water content and neutron matrix effect. We determined a PorosityNg granitecalibration neutron porosity. For this, the relationship between the N neutron counting rate and the PorosityNc standard neutron porosity (limestone calibration was analysed (Fig. 2 and Fig. 3. For neutron porosities ranging from 0. 5 to 100%, we also examined the behaviour of N as a function of the borehole diameter (Fig. 4. To avoid the problem of correcting the hole effect and to be able to compare the porosities determined by neutron logging and measurements performed on core samples no matter what the depth was, the neutron counting rate was recalculated (N63 for a constant diameter of 63 mm (chosen arbitrarily, (Fig. 5. Then, a calibration curve between the N63 counting rate and the PorosityNR total reconstituted neutron porosity was determined for all the granite samples. From this relationship, we calculated a PorosityNg neutron porosity, called granitecalibration neutron porosity. Then PorosityNR, PorosityNg and PorosityNc were compared (Fig. 7, Fig. 9 and Fig. 10. By substracting the PorosityNma neutron matrix effect from PorosityNg and PorosityNc, we obtained the ng and nc water content values that we compared to the n water content measured on core samples (Fig. 8 and Fig. 11. PorosityNR, PorosityNg and neutron porosities and n, ng and nc water contents (free water saturation, were compared for the different alteration facies of the Beauvoir granite (Fig. 12. On the whole, there was a better (qualitative and quantitative relationship between the PorosityNR total neutron porosity and the PorosityNg granitecalibration neutron porosity (which are about 9%, than with PorosityNc. The PorosityNc neutron porosity issuing from the limestone calibration was underestimated because the rock neutron matrix effect was not taken into account (around 7% for the Beauvoir granite. Concerning water contents, limestone calibration led to nc water content values that, in 60% of the cases, were less than 0% and hence unusable. On the other hand, the ng water content obtained from the granitecalibration neutron porosity was more satisfactory since it gave an average water content value in agreement with the total water porosity measured on core samples (2%. However, it can be noted that the average variations between PorosityNg and PorosityNc as well as between ng and nc for the different Beauvoir granite facies are not always coherent (Table 5. This phenomenon can be partly explained by the averaging effect of the values as well as the singular behaviour of some samples. Another reason for this is, above all, the lack of points in the low and high porosity ranges for plotting the granitecalibration curve. Considering the numerous error factors encountered during this type of experimental research, (eccentricity of the tool, non-existant granite calibration, difficult assessment of the total water porosity on core samples and of1he neutron matrix effect, . . . these results may be considered satisfactory. To conclude, we can say that it is possible to evaluate the total free water porosity of an unaltered or hardly altered granite not containing any chemical elements having a large neutron capture cross-section, by using neutron porosity. Two conditions must imperatively be respected :a The neutron tool must be calibrated in granite blocks for which we know the total neutron effect, the water content (total free water porosity and the neutron effect of the matrix, so as to obtain a more accurate evaluation of the total neutron porosity of the rock. b A fairly clear idea must be obtained of the average combined water content of the matrix (e. g. from cuttings or another log in order to evaluate the neutron matrix effect so as to be subsequently able to correct the porosity issuing from the neutron counting.

  3. Problem çözme becerileri eğitiminin ilköğretim altıncı sınıf öğrencilerinin sosyal ve duygusal öğrenme ihtiyaçları ve becerileri üzerine etkisi

    OpenAIRE

    Totan, Tarık; Kabasakal, Zekavet

    2012-01-01

    The objective of this study is to examine the effects of the problem solving skills training program on the social andemotional learning needs, which are task articulation, peer relations and self-regulation along with the social and emotionallearning skills of communication, problem solving, coping with stress and self-esteem enhancing skills, for sixth grade primaryschool students. In this research, true experimental design with pretest-posttest control group design was used and follow-upme...

  4. M(4-PridinkarboksialdehidNi(CN4.nG Hofmann Tipi Konak-Konuk Bileşiklerinin Kırmızıaltı Spektroskopik Özelliklerinin İncelenmesi (M = Ni, Cd ve G = 1,4-Dioksan

    Directory of Open Access Journals (Sweden)

    Zeki KARTAL

    2014-12-01

    M(4-PyridinecarboxaldehydeNi(CN4.nG Hofmann Type Clathrates (M = Ni, Cd and G = 1,4-Dioxane Abstract: In this study, clathrate of 4-pyridinecarboxaldehyde tetracyanonickel-dioxane, given by the formula M(4-PyridinecarboxaldehydeNi(CN4 nG (m = Ni, Cd and G = 1,4-dioxane, is obtained for the first time through chemical methods. The FT-IR spectroscopic data in the region of (3000–400 cm-1 was recorded and the IR vibrational modes frequencies were given and explained in detail. The spectral analyzes results of the newly synthesized clathrate of 4-pyridinecarboxaldehyde tetracyanonickel- dioxane suggests that these clathrates are new examples of the Hofmann-type dioxane clathrates. In our study, the Hofmann-type dioxane clathrates formed by bounding electrons of nitrogen-donor atom of pyridine ring and electrons of oxygen-donor atom of aldehyde group (-CH=O of 4-pyridinecarboxaldehyde ligand molecule to transition metal atoms consist of the corrugated |M–Ni(CN4|ï‚¥ polymeric layers which are held in parallel through the chain of (–M–4PCA–M–. Key words: Infrared Spectroscopy, Hofmann Types Clathrates, Tetracyanonickelate, 4-pyridinecarboxaldehyde, 1,4-dioxane

  5. Short-time synthesis of poly[4,6-bis(3′-(2-ethylhexyl)thien-2′-yl)thieno[3,4-c][1,2,5]thiadiazole-alt-9,9-dioctylfluorene], its photophysical, electrochemical and photovoltaic properties

    Czech Academy of Sciences Publication Activity Database

    Cimrová, Věra; Kmínek, Ivan; Výprachtický, Drahomír; Pokorná, Veronika

    2015-01-01

    Roč. 59, 24 February (2015), s. 298-304 ISSN 0032-3861 R&D Projects: GA ČR(CZ) GA13-26542S; GA ČR GAP106/12/0827 Institutional support: RVO:61389013 Keywords : low-bandgap thienothiadiazole copolymer * Suzuki coupling * photophysics and photovoltaics Subject RIV: CD - Macromolecular Chemistry Impact factor: 3.586, year: 2015

  6. Effects of alkyl or alkyloxy side chains in poly[4,6-bis(3´-dodecylthien-2´-yl)thieno-[3,4-c][1,2,5]thiadiazole-5´,5´-diyl-alt-2,5-di(alkyl or alkyloxy)-1,4-phenylene]: synthesis, photophysics, and spectroelectrochemical and photovoltaic properties

    Czech Academy of Sciences Publication Activity Database

    Cimrová, Věra; Pokorná, Veronika; Výprachtický, Drahomír

    2017-01-01

    Roč. 118, 2 June (2017), s. 180-191 ISSN 0032-3861 R&D Projects: GA ČR(CZ) GA13-26542S Institutional support: RVO:61389013 Keywords : low-bandgap thienothiadiazole copolymers * photophysics * spectroelectrochemistry Subject RIV: BM - Solid Matter Physics ; Magnetism OBOR OECD: Condensed matter physics (including formerly solid state physics, supercond.) Impact factor: 3.684, year: 2016

  7. Alte und neue Problemaspekte der Figur. Zu einem medienübergreifenden Versuch einer Begriffsbestimmung der Figur [Jens Eder / Fotis Jannidis / Ralf Schneider (Hg.: Characters in Fic­tional Worlds. Understanding Imaginary Beings in Literature, Film, and Other Media. Berlin 2010

    Directory of Open Access Journals (Sweden)

    Carmen Lăcan

    2012-12-01

    Full Text Available Rezension zu / Review of:Jens Eder / Fotis Jannidis / Ralf Schneider (Hg.: Characters in Fic­tional Worlds. Understanding Imaginary Beings in Literature, Film, and Other Media. Berlin 2010

  8. Sur l'origine par altération du substratum schisteux de la minéralisation chlorurée des eaux d'une nappe côtière sous climat semi-aride (Chtouka-Massa, Maroc)

    Science.gov (United States)

    Krimissa, Samira; Michelot, Jean-Luc; Bouchaou, Lhoussaine; Mudry, Jacques; Hsissou, Youssef

    2004-11-01

    The origin of chloride ions in groundwater from the Chtouka-Massa plain (Morocco) was studied by using chemical and isotopic analyses of water, and petrographic and chemical analyses of rocks. It appears that the schist formation, which forms the basement of the studied aquifer, is the main source of the high Cl - concentrations in groundwater. In these schists, chloride is, for a part, probably contained in biotites, and is released into groundwater through the weathering of these minerals. However, the exceptionally high chloride contents of these schists are difficult to explain if one does not assume that they also contain evaporitic-type minerals. To cite this article: S. Krimissa et al., C. R. Geoscience 336 (2004).

  9. Séquestration des matières organiques des sols par les nanominéraux : approche expérimentale de la formation de complexes organo-minéraux à partir des produits d'altération de la biotite

    OpenAIRE

    Tamrat , Wuhib Zewde

    2017-01-01

    Among soil organic matter (SOM) stabilization mechanisms, molecular scale organo-mineral interactions are thought to play a major role in stabilizing organic compounds. Because of their large surface area and reactivity, nanometric-size soil mineral phases have a high potential for SOM stabilization. In the literature, Fe and Al phases have been the main targets of batch-synthesized nanomineral studies while nano-aluminosilicates (phases in which Al is associated with Si) have been mainly stu...

  10. «Hvis de hadde oppført seg som vanlige nordmenn, hadde alt vært greit, tror jeg» — Nordmenns syn på årsaken til negative holdninger til jøder og muslimer

    Directory of Open Access Journals (Sweden)

    Vibeke Moe

    2016-04-01

    Full Text Available This article explores contemporary images of Jews and Muslims in Norway by using qualitative empirical data, namely the answers to an open-ended question that was included in a quantitative survey on attitudes towards Jews and other minorities in Norway, conducted in 2012. The target group for the survey consisted of Norwegian residents aged 18 and above. A total of 1522 people answered the questionnaire. The results of the survey can be considered as representative of the Norwegian population with respect to age, gender, education and geographical distribution. Respondents were asked what they regarded to be the reasons for existing negative attitudes towards Jews and Muslims respectively. This article analyzes whether the perceptions reflected in the respondents’ answers represent stereotypical views and partly include traces of conspiracy beliefs. The article also discusses these perceptions within the broader perspective of Norwegian society, asking in which ways the data reflects ideas of inclusion and exclusion. The analysis exposes differences regarding traditional stereotypes and prejudices against the two minorities and the ways in which these prejudices are linked to (perceived contemporary conflicts and tensions – both within Norwegian society and internationally. Negative attitudes towards Jews are often explained with reference to the role played by Israel in the Middle East conflict, and almost never with specific reference to Norwegian society. The material contains few examples describing Jews as scapegoats for current social problems in Norway. On the contrary, respondents’ answers indicate social distance. Approximately half of the answers claim that negative attitudes towards Jews are due to the Israeli-Palestinian conflict. The images of Jews presented in connection with this conflict are predominantly negative and characterized by topics such as oppression, ruthlessness and power. The analysis shows how these statements serve to reduce complexity by effectively equating “Jews” with “Israelis”. As a consequence Jews seem to be excluded from the notion of the Norwegian national collective. The statements about Muslims show that they are regarded to be citizens and as such part of Norwegian society, but with characteristics perceived as problematic and threatening. Respondents often connected negative attitudes towards Muslims with a “foreign culture”. Many statements describe Muslims as oppressive to women, as harboring undemocratic attitudes or as criminals. The data shows how people develop generalizations, describing something as “typically Muslim” or “typically Jewish”, reflecting current debates and media coverage. Such generalizations derive their strength from placing the speaker in a morally superior position. In the present material these attitudes represent the antithesis of an implicit notion of the Norwegian community as a liberal, egalitarian and peace-loving society. Despite the differences, a clear picture emerges that the characterizations of both Jews and Muslims seem to serve a common function: to provide a contrast to this national self-image. Such polarized notions of “us” and “them”, however, undermine the values generally constructed as “Norwegian”: when “the other” bears problematic features that we do not want to acknowledge in ourselves or our communities, we lose the ability to critically reflect on who we are. While maintaining an idealized notion of “us”, we become increasingly dependent on a rejection and denial of the “other”. 

  11. « Un épagneul, une femme et un noyer, plus nous les battons, meilleurs ils sont » : Frances Power Cobbe, la féminité et l’altérité “A spaniel, a woman and a walnut tree, the more they are beaten, the better they be”: Frances Power Cobbe, Femininity and Otherness

    Directory of Open Access Journals (Sweden)

    Emilie Dardenne

    2005-01-01

    Full Text Available Frances Power Cobbe was a remarkable Victorian and a very assertive woman, who was praised for both her astute feminist mind and her tenacious fight against animal experiments. She utterly disapproved of women being ranked as creatures whose whole existence depended on their relationship with another individual. She deplored their “wretched proverbial similarity to spaniels and walnut-trees”. In her writings, she tackled the theme of violence, especially that committed within the home by malicious husbands and she took strong exception to “the notion that a man’s wife is his PROPERTY”, because of the stigma attached to such a belief and because it made women—as well as animals—morally inferior to men.The following article provides an insight into Frances Power Cobbe’s perspective on domestic violence and her in-depth exploration of the concepts of femininity and otherness. It begins by explaining how the authoress of “Wife Torture in England” became the spokeswoman of beaten wives and it goes on to study her vision of femininity as conveyed through her discussion of violence, cruelty, appropriation, otherness and the fate of animals. The article concludes by trying to shed light on the image of femininity that Cobbe wishes to extol.

  12. Annelerin Ebeveynlik Öz Yeterlik Algıları ile Gelişimi Risk Altında Olan Bebeklerin Gelişimleri Arasındaki İlişkiyi İnceleyen Araştırmalara Bir Bakış

    Directory of Open Access Journals (Sweden)

    Veysel Aksoy

    2009-01-01

    Full Text Available Bu çalışmanın amacı, ebeveynlerin (özellikle annelerin öz yeterlik düzeyleri ile çocuklarının erken çocukluk dönemindeki gelişimleri arasındaki ilişkiyi inceleyen araştırmaları gözden geçirmektir. Bu amaçla betimsel alan yazın taraması yapılmıştır. Ele alınan makalelerdeki bulgular, annelerin sahip olduğu ebeveyn öz yeterlik algısının düzeyi ile çocukların bilişsel, sosyal ve dil gelişimleri arasında ilişki olduğunu göstermektedir. Ayrıca ebeveynlik öz yeterlik düzeyleri sosyo-ekonomik durum, sosyal destekler, bekâr anne olma ve annelik yaşı gibi değişkenlerden etkilenmektedir. Annelerin öz yeterlikleriyle çocuğun problem davranışları, annelik depresyonu ve stresi gibi değişkenler arasında da ilişkiler olduğu çalışmalarda rapor edilmiştir. The purpose of this study is to overview studies on relationship between the parental self-efficacy levels (especially mothers’ self-efficacy and development of their young children. For this purpose, a narrative literature review was carried out. Based on the review of the literature, it is observed that there are relationships between the parental self-efficacy and children’s cognitive, social and language development. Moreover, parental self-efficacy level is affected by some variables such as socio-economical condition, social supports, being a single mother and mother’s age. Also, studies pointed out that there is a relationship between selfefficacy levels of mothers and child’s problem behaviors, maternal depression and stress.

  13. Environmental analysis of radiation exposure by radon in Saxon buildings and impact of the EnEV. An old problem in a new dimension; Umweltanalyse zur Strahlenbelastung durch Radon in saechsischen Gebaeuden und Auswirkungen der EnEV. Ein altes Problem mit neuen Dimensionen

    Energy Technology Data Exchange (ETDEWEB)

    Gottwald, Jan; Schneider, Lutz [Stoller Ingenieurtechnik GmbH, Dresden (Germany); Koeter, Nico [TU Bergakademie Freiberg (Germany)

    2015-07-01

    Radon in buildings is being widely studied since the 1990s. These studies have revealed some cases of very high radiation exposure for the inhabitants of residential buildings in Saxony in particular. Even a proposed raising of the radon reference values from 100 Bq/m{sup 3} to 300 Bq/m{sup 3} (in the case of an eventually 1:1 implementation of the EU recommendations into German law), would not even slightly aid the situation in the designated areas with high radon availability, as the standards of the Energieeinsparverordnung (Energy Saving Ordinance, EnEV) can result in significant radiation exposure, if no comprehensive radon protection is implemented. Based on long-term radon measurements in Saxony from the nineties, before the introduction of the EnEV, this report will show potential outcomes and estimate the extend of suitable remediation measures.

  14. Diversitatea speciilor de păsări în culturi energetice de plop cu ciclu scurt de producţie: o comparație cu alte categorii de folosinţă a terenurilor [Bird species diversity in poplar plantations: a comparison with different land use categories

    Directory of Open Access Journals (Sweden)

    Dănilă Gabriel

    2015-12-01

    Full Text Available The energy poplar plantations are in expansion in the north-eastern Romania, so the aim of our study was to investigate the influence of these plantations on avian diversity. We carried out bird counts in two experimental blocks of 10 ha, where semi-natural forest vegetation, pastures, poplar plantations and agricultural land live in similar surface areas. The bird richness and abundance are the highest in forest vegetation, followed by agricultural lands, pastures and poplar plantations; the last ones are used by birds only for foraging, not for nesting and breeding. The landscape parameter analysis reveals for now a high variability due to relatively small size patches with different land uses, with complex edges and adequate connectivity, offering proper conditions for diverse bird species. The trend of extending the agricultural monocultures (especially colza and poplar plantations observed in the last years will have a negative impact on local bird communities. If this going to be the case, in order to soften this effect, it is advisable to avoid large areas with simple edges of poplar or agricultural plantations, to maintain the hedgerows alongside plantations and the areas with different land use to alternate in space.

  15. The complete nucleotide sequence of Alternanthera mosaic virus infecting Portulaca grandiflora represents a new strain distinct from phlox isolates.

    Science.gov (United States)

    Ivanov, Peter A; Mukhamedzhanova, Anna A; Smirnov, Alexander A; Rodionova, Nina P; Karpova, Olga V; Atabekov, Joseph G

    2011-04-01

    A southeastern European isolate of Alternanthera mosaic virus (AltMV-MU) of the genus Potexvirus (family Flexiviridae) was purified from the ornamental plant Portulaca grandiflora. The complete nucleotide sequence (6606 nucleotides) of AltMV-MU genomic RNA was defined. The AltMV-MU genome is different from those of all isolates described earlier and is most closely related to genomes of partly sequenced portulaca isolates AltMV-Po (America) and AltMV-It (Italy). Phylogenetic analysis supports the view that AltMV-MU belongs to a new "portulaca" genotype distinguishable from the "phlox" genotype.

  16. Spirituality, Crisis, and Illusions

    Directory of Open Access Journals (Sweden)

    LOSONCZ, Alpar

    2016-03-01

    Full Text Available This article deals with the structural interpretations of the ongoing crisis. The author considers the approaches of Joseph Alois Schumpeter and Tibor Scitovsky that thematize the long-run destiny of capitalism. The viewpoint is constituted as the relation between the structural socio-economic tendencies and existential constellations. What is addressed by the crisis is capitalism as a dependent system. The author emphasizes that capitalism cannot survive without the outside sphere, reciprocal interactions, economics of community, eco-system and complex eco-social moments. This can be applied to the frequently mentioned embeddedness which is related to Polanyi and other researchers who are influenced by Polanyi’s concepts. Embeddedness can be analyzed through the holon, from the inside perspective. Only comprehensive perspective enables to see the entire horizon, since capitalism cannot summarize the eco-system, not even with the most sophisticated techniques that recognize monetary expressions.

  17. Estoniasse sõidab teatribuss

    Index Scriptorium Estoniae

    2007-01-01

    Septembris sõidutab Virumaa teatribuss soovijaid neljale Rahvusooperi Estonia etendusele: lastelavastus "Pipi! Nuki! Puhh!" 12. sept., operett "Viini veri" 13. sept., ooper "Tuhkatriinu" 14. sept., ballett "Sülfiid" 15. septembril. Rahvusooper Estonia alustab 102. hooaega: traditsiooniline turupäev 9. sept., Ludwig Minkuse ballett "Don Quijote" (lavastaja Tiit Härm) 4. okt., A. Dvoraki "Reekviem" Tallinnas 1. nov., Tartus 2. nov ja Pärnus 3. nov., Neeme Kuninga lavastatud G. Verdi ooper "Rigoletto" 9. nov., Lehari "Lõbus Lesk" 28. nov., Tibor Kocsaki lasteballett "Lumivalgeke ja seitse pöialpoissi" (lavastaja Gyula Harangozo) 1. veebr. 2008, G. Verdi ooperi "Simon Boccanegra" kontsertettekanne 15. märtsil, muusikali "Minu veetlev leedi" (lavastaja Ago-Endrik Kerge) esietendus 3. apr., R. Wagneri ooper "Tristan ja Isolde" (lavastaja Neeme Kuningas) 17. mail (info: www. opera.ee)

  18. Recenzije, prikazi

    OpenAIRE

    2014-01-01

    Lubomíra Havlíková, Peter Ivanič, Martin Hetényi: Po stopách sv. Cyrila a Metoda: výberová bibliografi a českýcha a slovenských prác za roky 1945 – 2011 = In the footsteps of St. Cyril ant Methodus: selective bibliography of works from Bohemia and Slovakia published in 1945 – 2011, Nitra, 2013. (Marijan ŠABIĆ); Tibor Neumann (prir.): A Szapolyai család oklevéltára I. Levelek és oklevelek (1458-1526) / Documenta Szapolyaiana I. Epistulae et litterae (1458-526), Budapest, 2012. (Stanko ANDRIĆ);...

  19. 78 FR 61000 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Science.gov (United States)

    2013-10-02

    ...; Puerto de Hierro, Zapopan, Jalisco, Mexico; Fresno, CA; DOB 3 Apr 1972; alt. DOB 1960; alt. DOB 1966; POB..., Jaslico, Mexico; Vereda Del Canario 1, Guadalajara, Jalisco, Mexico; Puerto de Hierro, Zapopan, Jalisco...

  20. What Is Hepatitis?

    Science.gov (United States)

    ... Navigation Alt+1 Content Alt+2 What is hepatitis? Online Q&A Reviewed July 2016 Q: What ... Question and answer archives Submit a question World Hepatitis Day Posters: Eliminate hepatitis World Hepatitis Day 2017 ...

  1. Alanine aminotransferase and mortality in patients with type 2 diabetes (ZODIAC-38)

    NARCIS (Netherlands)

    Deetman, Petronella E.; Alkhalaf, Alaa; Landman, Gijs W. D.; Groenier, Klaas H.; Kootstra-Ros, Jenny E.; Navis, Gerjan; Bilo, Henk J. G.; Kleefstra, Nanne; Bakker, Stephan J. L.

    Introduction Combined data suggest a bimodal association of alanine aminotransferase (ALT) with mortality in the general population. Little is known about the association of ALT with mortality in patients with type 2 diabetes. We therefore investigated the association of ALT with all-cause,

  2. 78 FR 34705 - Designation of 3 Individuals and 10 Entities Pursuant to Executive Order 13224 of September 23...

    Science.gov (United States)

    2013-06-10

    ... policy, or economy of the United States; (3) persons determined by the Director of OFAC, in consultation... May 1956; nationality Iran; Passport E1929795 (Iran) expires 25 May 2010; alt. Passport V08716254 (Iran) expires 15 Jul 2011; alt. Passport V11630399 (Iran) expires 20 Jun 2012; alt. Passport U8356901...

  3. NCBI nr-aa BLAST: CBRC-MEUG-01-1506 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available musculus] sp|Q8BX46|LBXCO_MOUSE RecName: Full=Ladybird homeobox corepressor 1; AltName: Full=Lbx1 corepress...or 1; AltName: Full=Transcriptional corepressor Corl1; AltName: Full=Fussel-15 gb|EDL26034.1| ladybird homeo

  4. NCBI nr-aa BLAST: CBRC-MLUC-01-0097 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available Includes: RecName: Full=Leader peptidase; AltName: Full=Prepilin peptidase; Includes: RecName: Full=N-methyl...leader peptide-processing enzyme; AltName: Full=Protein secretion protein XCPA; AltName: Full=Protein pilD;

  5. The Effects of Trained Peer Tutors on the Physical Education of Children Who Are Visually Impaired

    Science.gov (United States)

    Wiskochil, Brian; Lieberman, Lauren J.; Houston-Wilson, Cathy; Petersen, Susan

    2007-01-01

    This study examined the effect of trained peer tutors on the academic learning time-physical education (ALT-PE) scores of children with visual impairments. It found a mean increase of 20.8% for ALT-PE and increases in ALT-PE scores for closed and open skills and that trained peer tutors were more effective than were untrained peer tutors.

  6. Alcohol intake, alcohol dehydrogenase genotypes, and liver damage and disease in the Danish general population

    DEFF Research Database (Denmark)

    Tolstrup, J.S.; Gronbaek, M.; Tybjaerg-Hansen, A.

    2009-01-01

    the Copenhagen City Heart Study. Biochemical tests for the detection of liver damage were specific for alanine aminotransferase (ALT), aspartate aminotransferase (AST)-to-ALT ratio (AST/ALT), gamma-glutamyl transpeptidase (gamma-GT), albumin, bilirubin, alkaline phosphatase, coagulation factors, and erythrocyte...... volume. RESULTS: Increasing alcohol intake was associated with increasing erythrocyte volume, AST/ALT, and levels of ALT, gamma-GT, albumin, bilirubin, coagulation factors, and with decreasing levels of alkaline phosphatase. Multifactorially adjusted hazard ratios for alcoholic liver disease overall were...

  7. The effect of a 6-week land and resistance training of 13-16 years old swimmers groups to lower limb isokinetic strength values and to swimming performance13-16 yaş grubu yüzücülerde 6 haftalık kara ve direnç antrenmanlarının alt ekstremite izokinetik kuvvet performansına ve yüzme derecelerine etkisi

    OpenAIRE

    Yapıcı, Ayşegül; Maden, Barış; Fındıkoğlu, Gülin

    2016-01-01

    The aim of this study is to investigate the effect of a 6-week land and resistance training of 13-16 year old swimmers groups to lower limb isokinetic strength values and to swimming performance. 22 swimmers participated in this study. The subjects were divided into three groups (A-B-C) according to their 50m swimming degrees. 25m underwater,25m,50m,75m and 100m freestyle swimming degrees of swimmers were recorded. As isokinetic measurements was applied at 60°/s,180°/s and 240°/s speed and th...

  8. Déferlante d’enclosures au Pérou : une nouvelle vague d’altération du lien social et des rapports Nature-Cultures Breaking Enclosures in Peru: A new Wave of Change in the Social Bond and in the Relationship of Nature and Cultures Olas de enclosure en el Perú: una nueva onda de alteración del vínculo social y de las relationes Naturaleza-Culturas

    Directory of Open Access Journals (Sweden)

    Nicolas Merveille

    2012-05-01

    Full Text Available La nation péruvienne vit depuis le début de la décennie une nouvelle vague de confiscation de ses biens communs. Loin de s’être achevé le processus de déprédation des ressources ne cesse de se complexifier et radicaliser. La présente contribution, formulée d’après la métaphore du jeu de Monopoly, propose une lecture contemporaine des dynamiques territoriales et tente d’expliciter le profil des joueurs, leurs tactiques de jeu et évaluer les nouveaux défis qu’affrontent le Pérou.For a decade, the Peruvian nation has witnessed a new wave of confiscation of common assets.  Far from ending, the process of resource predation continues to become more complex and embedded.  The present contribution, formulated around the metaphor of the game Monopoly, offers a contemporary reading of these territorial dynamics, attempting to clarify the nature of the players and their gaming tactics, as well as offering an assessment of the new challenges Peru now faces.  La nación peruana vive desde el inicio de la década una nueva ola de confiscación de sus bienes comunes. Lejos de ser acabado, el proceso de depredación de los recursos se hace más complejo y se radicaliza. La presente contribución, formulada desde la metáfora del juego de Monopolio, propone una lectura contemporánea de las dinámicas territoriales y trata explicar el perfil de los jugadores, sus tácticas de juego y evaluar los nuevos desafíos que afrontan el Perú.

  9. An accelerated life test model for harmonic drives under a segmental stress history and its parameter optimization

    Directory of Open Access Journals (Sweden)

    Zhang Chao

    2015-12-01

    Full Text Available Harmonic drives have various distinctive advantages and are widely used in space drive mechanisms. Accelerated life test (ALT is commonly conducted to shorten test time and reduce associated costs. An appropriate ALT model is needed to predict the lifetime of harmonic drives with ALT data. However, harmonic drives which are used in space usually work under a segmental stress history, and traditional ALT models can hardly be used in this situation. This paper proposes a dedicated ALT model for harmonic drives applied in space systems. A comprehensive ALT model is established and genetic algorithm (GA is adopted to obtain optimal parameters in the model using the Manson fatigue damage rule to describe the fatigue failure process and a cumulative damage method to calculate and accumulate the damage caused by each segment in the stress history. An ALT of harmonic drives was carried out and experimental results show that this model is acceptable and effective.

  10. Teoria wielości rzeczywistości Leona Chwistka. Rys krytyczny

    Directory of Open Access Journals (Sweden)

    Hubert Bożek

    2014-12-01

    Full Text Available The purpose of this paper is to offer a logico‑philosophical critical overview of the theory of multiple realities (TWR. The paper is divided into three sections. In the first section I present a brief history of the development of some ideas, which combined together form the conceptual framework of the theory in question, whose main thesis is that there is more than one reality. In the second part I present (and try to address some interpretations of TWR, which can be described as: ontological; epistemological; esthetical; logical ad mixed interpretations. When doing so, a special emphasis is laid on the presentation of an explication of TWR based on theory of models, an explication authored by Teresa Kostyrko. This explication rests on a conditional recognition of the particular ‘realities’ of Chwistek’s theory as proper models (i.e. those, which fulfill the condition of the identity of meaning of theory’s fundamental notions of the theories of reality, with the provision that such models are indeed constructible. In the last section of my paper I propose a preliminary appraisal of the TWR as well as a way to reengineer this theory in order to avoid some of its difficulties. By appealing to Kostyrko’s idea on one hand and the spirit Quinean ontological relativism on the other, I wish to argue as follows: (1 ‘reality’ is the name of the set comprising all meanings of the term ‘reality’; (2 under particular conditions these meanings can be arranged in a theory, which possesses a proper model (scientific discourse, some forms of the common talk; (3 model proper designate by definition classes of objects, which we regard as existent on the grounds of a given theory. The above set of theses forms the core of a concept, which I propose to call the ‘manifold reality’ in order to differentiate it from TWR, the development of which theory it is, as well as its modification towards a new kind of ontology.

  11. Theoretical Investigation on the Electronic and Optical Properties of Poly(fluorenevinylene Derivatives as Light-Emitting Materials

    Directory of Open Access Journals (Sweden)

    Thanisorn Yakhanthip

    2011-01-01

    Full Text Available Density functional theory (DFT and time-dependent DFT (TDDFT were employed to study ground-state properties, HOMO-LUMO gaps (ΔH-L, excitation energies (Eg, ionization potentials (IPs, and electron affinities (EA for PFV-alt-PDONV and PFV-alt-PDIH-PPV having different alternating groups. Excited-state properties were investigated using configuration interaction singles (CISs while fluorescence energies were calculated using TDDFT. The results show that PFV-alt-PDONV exhibits blue-shifted energies for both HOMO-LUMO gaps (ΔH-L and excitation energies (Eg compared with PFV-alt-PDIH-PPV. The predicted IP and EA clearly indicate that PFV-alt-PDIH-PPV has both easier hole creation and electron injection than that of PFV-alt-PDONV. The maximal absorption wavelengths of all polymers are strongly assigned to π→π∗ transition. The predicted radiative lifetimes of PFV-alt-PDONV and PFV-alt-PDIH-PPV for B3LYP/6-31G(d are 0.36 and 0.61 ns, respectively, indicating that PFV-alt-PDIH-PPV should have a better performance for long-time emission than that of PFV-alt-PDONV.

  12. A Micro-Platinum Wire Biosensor for Fast and Selective Detection of Alanine Aminotransferase

    Directory of Open Access Journals (Sweden)

    Tran Nguyen Thanh Thuy

    2016-05-01

    Full Text Available In this study, a miniaturized biosensor based on permselective polymer layers (overoxidized polypyrrole (Ppy and Nafion® modified and enzyme (glutamate oxidase (GlutOx immobilized micro-platinum wire electrode for the detection of alanine aminotransferase (ALT was fabricated. The proposed ALT biosensor was measured electrochemically by constant potential amperometry at +0.7 V vs. Ag/AgCl. The ALT biosensor provides fast response time (~5 s and superior selectivity towards ALT against both negatively and positively charged species (e.g., ascorbic acid (AA and dopamine (DA, respectively. The detection range of the ALT biosensor is found to be 10–900 U/L which covers the range of normal ALT levels presented in the serum and the detection limit and sensitivity are found to be 8.48 U/L and 0.059 nA/(U/L·mm2 (N = 10, respectively. We also found that one-day storage of the ALT biosensor at −20 °C right after the sensor being fabricated can enhance the sensor sensitivity (1.74 times higher than that of the sensor stored at 4 °C. The ALT biosensor is stable after eight weeks of storage at −20 °C. The sensor was tested in spiked ALT samples (ALT activities: 20, 200, 400, and 900 U/L and reasonable recoveries (70%~107% were obtained.

  13. Defibrillator charging before rhythm analysis significantly reduces hands-off time during resuscitation

    DEFF Research Database (Denmark)

    Hansen, L. K.; Folkestad, L.; Brabrand, M.

    2013-01-01

    BACKGROUND: Our objective was to reduce hands-off time during cardiopulmonary resuscitation as increased hands-off time leads to higher mortality. METHODS: The European Resuscitation Council (ERC) 2005 and ERC 2010 guidelines were compared with an alternative sequence (ALT). Pulseless ventricular...... physicians were included. All had prior experience in advanced life support. Chest compressions were shorter interrupted using ALT (mean, 6.7 vs 13.0 seconds). Analyzing data for ventricular tachycardia scenarios only, hands-off time was shorter using ALT (mean, 7.1 vs 18.2 seconds). In ERC 2010 vs ALT, 12...... physicians were included. Two physicians had not prior experience in advanced life support. Hands-off time was reduced using ALT (mean, 3.9 vs 5.6 seconds). Looking solely at ventricular tachycardia scenarios, hands-off time was shortened using ALT (mean, 4.5 vs 7.6 seconds). No significant reduction...

  14. C3 EVAL Model Development and Test. Volume 2. Programmers Manual.

    Science.gov (United States)

    1985-10-01

    requests for CAS (message types 2900, 3000, 3400) and has a non- 61 - ~~.t -o-5. Sd% NODE MESSAGE DEST DEST PLINK LINKI ALT1 LINK2 ALT2 . LINKP • LINKA1...LINKA2 LINKn ALTi PLINK LINKI LINK2 LINKn ALT2 PLINK LINKI LINK2 * LINKn Figure 13: PARAMETERS IN COMMUNICATIONS ALLOCATION null pointer to its...SUBROUTINE HOLDQ1 (IPASS) * MOVE PRIORITY MESSAGES FROM HOLD QUEUE TO ALTERNATE * COMMUNICATIONS LINKI SEND QUEUE * CALLS - SNAP, FIND

  15. NCBI nr-aa BLAST: CBRC-GGOR-01-0205 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available ic adhesive protein; AltName: Full=Foot protein 1; AltName: Full=MEFP1 emb|CAA38294.1| polyphenolic adhesive protein [Mytilus edulis] Q25460 2e-60 29% ... ...CBRC-GGOR-01-0205 sp|Q25460|FP1_MYTED RecName: Full=Adhesive plaque matrix protein; AltName: Full=Polyphenol

  16. Effect of streptococcal preparation (picibanil) on the postoperative rise in serum alanine aminotransferase activity in patients with urogenital cancer.

    OpenAIRE

    Taketa, Kazuhisa; Ohmori, Hiroyuki; Matsumura, Yonesuke; Asahi, Toshihiko; Okimune, Masaaki

    1980-01-01

    The effect of Picibanil, a streptococcal agent, on the development of liver injury after operations for urogenital cancer was studied retrospectively in the light of serum alanine aminotransferase (ALT) activity. The series comprised 32 cases receiving Picibanil and 33 controls with otherwise comparable clinical backgrounds. Picibanil reduced the incidence of postoperative ALT rise over 50 U/l within 6 weeks but increased it thereafter. The increase in ALT activity after 6 weeks was relativel...

  17. After four months new privatisation committee in SE

    International Nuclear Information System (INIS)

    Janoska, J.

    2003-01-01

    In spite of a delay the Minister of Economy of the Slovak Republic wants to meet the schedule set by Government. In middle of September 2002 six prospect submitted their tender offers for entering Slovenske elektrarne (SE), a.s, Bratislava. Representative of privatisation advisor of SE, PricewaterhouseCoopers, Peter Mitka told TREND that he was in contact with the investors but they were waiting for a signal from official authorities about the current state of the tender. And they have been waiting for four months. Only last week a new privatisation commission started dealing with the offers. In spite of these facts Minister of Economy, Robert Nemcsics does not consider the process slow and said that the Ministry would use all its efforts to adhere to the original privatisation schedule prepared by the former government. He further added that everything would depend on the offers submitted. Investors are not interest in SE as a whole but only in its parts. Several members of the committee do not agree with the privatisation and restructuring principles set by the government including a split of SE to conventional and nuclear parts. One of the opponents is the former manager of SE Tibor Mikus (HZDS) - representative of the Parliament or Vladimir Mojs representative of Slovak Energeticists Unions. This put a brake on the tender and changes in the management of SE as well. Privatisation Agency FNM still has not decided upon calling a Extraordinary General Meeting of SE that would elect new bodies. Spokeswoman of FNM, Tatjana Lesajova claims that the Fund is still missing a legal analysis that would review the possibility of changing SE's Articles of Association so that the Board of Directors could be assigned based on a tender (proposal of the Ministry). Members of SE Privatisation Committee: Eva Simkova - Secretary of State, Ministry of Economy SR; Laszlo Pomothy - Secretary of State, Ministry of Economy SR; Henrich Herceg - Advisor to the Minister of Economy SR

  18. Kunstihoones saab vastutustundlikult vahetuskaupa teha / Andris Feldmanis

    Index Scriptorium Estoniae

    Feldmanis, Andris, 1982-

    2006-01-01

    Tutvustatakse Andrea Creutzi kunstiprojekti "Varjatud ressursivoog", mis on osa Tallinna Kunstihoones eksponeeritavast näitusest "Kapital (See veab meid alt)". Näitus tegeleb alternatiivsete majandusmudelitega

  19. Inhibition study of alanine aminotransferase enzyme using sequential online capillary electrophoresis analysis.

    Science.gov (United States)

    Liu, Lina; Chen, Yuanfang; Yang, Li

    2014-12-15

    We report the study of several inhibitors on alanine aminotransferase (ALT) enzyme using sequential online capillary electrophoresis (CE) assay. Using metal ions (Na(+) and Mg(2+)) as example inhibitors, we show that evolution of the ALT inhibition reaction can be achieved by automatically and simultaneously monitoring the substrate consumption and product formation as a function of reaction time. The inhibition mechanism and kinetic constants of ALT inhibition with succinic acid and two traditional Chinese medicines were derived from the sequential online CE assay. Our study could provide valuable information about the inhibition reactions of ALT enzyme. Copyright © 2014 Elsevier Inc. All rights reserved.

  20. Identification of DNA-binding sites for the activator involved in late transcription of the temperate lactococcal phage TP901-1

    DEFF Research Database (Denmark)

    Pedersen, Margit; Kilstrup, Mogens; Hammer, Karin

    2006-01-01

    Alt, encoded by the lactococcal phage TP901-1, is needed for late transcription. We identify Alt as a DNA-binding protein, and footprint analysis shows that Alt binds to a region containing four imperfect direct repeats (ALT boxes) located -76 to -32 relative to the P-late transcriptional start...... site. The importance of the ALT boxes was confirmed by deletion of one or two ALT boxes and by introducing mutations in ALT boxes 1 and 4. Alt is proposed to act as a tetramer or higher multimer activating transcription of TP901-1 late genes by binding to the four ALT boxes, and bending of the DNA may...... be important for transcriptional activation of P-late. Furthermore, our results suggest that DNA replication may be required for late transcription in TP901-1. Additionally, we identify gp28 of the related lactococcal phage Tuc2009 as an activator and show that the activators required for late transcription...

  1. A Case of Apparent Life-Threatening Event: Comorbid Gastric Volvulus Associated Gastroesophageal Reflux Disease and Epilepsy in a 4-Month-Old Boy

    Directory of Open Access Journals (Sweden)

    Yoshihiko Takano

    2016-01-01

    Full Text Available Most isolated episodes of apparent life-threatening events (ALTEs do not lead to the diagnosis of serious conditions, and their prognoses are generally benign. However, recurrent ALTEs are often associated with a risk of future serious adverse events and should be evaluated for appropriate management. Here we present ALTE case in which gastric volvulus associated gastroesophageal reflux disease was detected as an etiology initially, followed by the detection of epilepsy as another etiology. Clinicians should consider possibility of two or more etiologies in a single recurrent ALTE case.

  2. Current distribution and ac susceptibility response of a thin superconducting disc in an axial field: a theoretical approach

    Science.gov (United States)

    Aruna, S. A.; Zhang, P.; Lin, F. Y.; Ding, S. Y.; Yao, X. X.

    2000-04-01

    Within the framework of the thermally activated process of the flux line or flux line bundles, and by time integration of the 1D equation of motion of the circulating current density icons/Journals/Common/vecJ" ALT="vecJ" ALIGN="TOP"/> (icons/Journals/Common/rho" ALT="rho" ALIGN="TOP"/> ,t ), which is suitable for thin superconducting films (R >>d ,icons/Journals/Common/le" ALT="le" ALIGN="TOP"/> icons/Journals/Common/lambda" ALT="lambda" ALIGN="TOP"/> ), we present numerical calculations of the current profiles, magnetization hysteresis loops and ac susceptibility icons/Journals/Common/chi" ALT="chi" ALIGN="TOP"/> n = icons/Journals/Common/chi" ALT="chi" ALIGN="TOP"/> ´n +iicons/Journals/Common/chi" ALT="chi" ALIGN="TOP"/> ´´n for n = 1, 3 and 5 of a thin disc immersed in an axial time-dependent external magnetic field Ba (t ) = Bdc +Bac cos(2icons/Journals/Common/pi" ALT="pi" ALIGN="TOP"/> icons/Journals/Common/nu" ALT="nu" ALIGN="TOP"/> t ). Our calculated results are compared with those of the critical state model (CSM) and found to prove the approximate validity of the CSM below the irreversibility field. The differences between our computed results and those of the CSM are also discussed.

  3. Statin-related aminotransferase elevation according to baseline aminotransferases level in real practice in Korea.

    Science.gov (United States)

    Kim, H-S; Lee, S H; Kim, H; Lee, S-H; Cho, J H; Lee, H; Yim, H W; Kim, S-H; Choi, I-Y; Yoon, K-H; Kim, J H

    2016-06-01

    Higher rate of statin-related hepatotoxicity has been reported for Koreans than for Westerners. Moreover, statin-related aminotransferase elevation for those who show borderline levels of aspartate transaminase (AST) and alanine transaminase (ALT) (≤×3 of UNL) at baseline has not been fully investigated. Post-statin changes AST/ALT levels during the first year for 21 233 Korean outpatients at two large academic teaching hospitals from January 2009 to December 2013 were analysed using electronic health record data. The date of the first statin prescription was set as baseline. We also performed a comparative analysis of statin-related AST/ALT elevations according to the type of statin, followed by an analysis of clinical risk factors. The progression rate to abnormal AST/ALT values [>×3 the upper normal limit (UNL)] was significantly higher (2·4-16% vs. 0·3-1·7%, P ×1, but ≤×3 of UNL) compared with normal AST/ALT values at baseline. Those with normal baseline AST/ALT did not show significantly different progression rate between different statin medications (P = 0·801). However, patients taking pitavastatin (HR = 0·76, P = 0·657) were least likely to develop abnormal AST/ALT, whereas those taking fluvastatin (HR = 2·96, P = 0·029) were the most likely to develop abnormal AST/ALT compared with atorvastatin for patients who were with baseline borderline AST/ALT. However, given the small sample sizes and the observational nature of our study, these need further study. It is advisable to regularly monitor AST/ALT levels even in patients with AST/ALT increases >×1. Future studies should aim to determine the possible risk factors for each specific statin type by analysing various confounding variables. © 2016 The Authors. Journal of Clinical Pharmacy and Therapeutics Published by John Wiley & Sons Ltd.

  4. Bacillus spp. produce antibacterial activities against lactic acid bacteria that contaminate fuel ethanol plants.

    Science.gov (United States)

    Manitchotpisit, Pennapa; Bischoff, Kenneth M; Price, Neil P J; Leathers, Timothy D

    2013-05-01

    Lactic acid bacteria (LAB) frequently contaminate commercial fuel ethanol fermentations, reducing yields and decreasing profitability of biofuel production. Microorganisms from environmental sources in different geographic regions of Thailand were tested for antibacterial activity against LAB. Four bacterial strains, designated as ALT3A, ALT3B, ALT17, and MR1, produced inhibitory effects on growth of LAB. Sequencing of rRNA identified these strains as species of Bacillus subtilis (ALT3A and ALT3B) and B. cereus (ALT17 and MR1). Cell mass from colonies and agar samples from inhibition zones were analyzed by matrix-assisted laser desorption/ionization-time of flight mass spectrometry. The spectra of ALT3A and ALT3B showed a strong signal at m/z 1,060, similar in mass to the surfactin family of antimicrobial lipopeptides. ALT3A and ALT3B were analyzed by zymogram analysis using SDS-PAGE gels placed on agar plates inoculated with LAB. Cell lysates possessed an inhibitory protein of less than 10 kDa, consistent with the production of an antibacterial lipopeptide. Mass spectra of ALT17 and MR1 had notable signals at m/z 908 and 930 in the whole cell extracts and at m/z 687 in agar, but these masses do not correlate with those of previously reported antibacterial lipopeptides, and no antibacterial activity was detected by zymogram. The antibacterial activities produced by these strains may have application in the fuel ethanol industry as an alternative to antibiotics for prevention and control of bacterial contamination.

  5. Check Mate! The CERN vs Fermilab Chess Competition

    CERN Multimedia

    2001-01-01

    7,000 kilometers and a 7 hour time difference had no impact upon the enthusiasm that pervaded the chess competition between CERN and Fermilab. In spite of the computer era, one game was played over a real wooden board.  Tomas Davidek and Irwin Gaines took advantage of Irwin's momentary presence at CERN. Several chess servers span the world and they are used by all sorts of people from many walks of life. However in mid-November on freechess.org there was a sudden influx of physicists as CERN and Fermilab faced off in their first online chess match. While technically a competition, the aim of the match was above all a 'friendly' contest between the two sister labs.  Usually, in serious chess competitions, each team plays in its strongest available constellation at the moment of the match.  But both CERN and Fermilab did quite the opposite and made getting all interested players involved the top priority. 'This was all put together for the purpose of having good fun' said Tibor Sim...

  6. High Accuracy Potential Energy Surface, Dipole Moment Surface, Rovibrational Energies and Line List Calculations for ^{14}NH_3

    Science.gov (United States)

    Coles, Phillip; Yurchenko, Sergei N.; Polyansky, Oleg; Kyuberis, Aleksandra; Ovsyannikov, Roman I.; Zobov, Nikolay Fedorovich; Tennyson, Jonathan

    2017-06-01

    We present a new spectroscopic potential energy surface (PES) for ^{14}NH_3, produced by refining a high accuracy ab initio PES to experimental energy levels taken predominantly from MARVEL. The PES reproduces 1722 matched J=0-8 experimental energies with a root-mean-square error of 0.035 cm-1 under 6000 cm^{-1} and 0.059 under 7200 cm^{-1}. In conjunction with a new DMS calculated using multi reference configuration interaction (MRCI) and H=aug-cc-pVQZ, N=aug-cc-pWCVQZ basis sets, an infrared (IR) line list has been computed which is suitable for use up to 2000 K. The line list is used to assign experimental lines in the 7500 - 10,500 cm^{-1} region and previously unassigned lines in HITRAN in the 6000-7000 cm^{-1} region. Oleg L. Polyansky, Roman I. Ovsyannikov, Aleksandra A. Kyuberis, Lorenzo Lodi, Jonathan Tennyson, Andrey Yachmenev, Sergei N. Yurchenko, Nikolai F. Zobov, J. Mol. Spec., 327 (2016) 21-30 Afaf R. Al Derzia, Tibor Furtenbacher, Jonathan Tennyson, Sergei N. Yurchenko, Attila G. Császár, J. Quant. Spectrosc. Rad. Trans., 161 (2015) 117-130

  7. Partially melted zone cracking in AA6061 welds

    International Nuclear Information System (INIS)

    Prasad Rao, K.; Ramanaiah, N.; Viswanathan, N.

    2008-01-01

    Partially melted zone (PMZ) cracking susceptibility in AA6061 alloy was studied. Role of prior thermal history, gas tungsten arc welding techniques such as continuous current (CC) and pulsed current (PC) and use of different fillers (AA4043 and AA5356) were studied. Role of different grain refiners such as scandium, zirconium and Tibor in the above fillers was studied. Varestraint test was used to study the PMZ cracking susceptibility. Metallurgical analysis was done to corroborate the results. PMZ cracking was severe in T6 temper than in T4 irrespective of filler material. PMZ cracking susceptibility was more with AA5356 than in AA4043. It was less with pulsed current GTAW. PMZ cracking susceptibility was reduced with addition of grain refiners. Out of all, lowest PMZ cracking susceptibility was observed with 0.5%Sc addition to fusion zone through AA4043 filler and PC technique. The concentrations of magnesium and silicon were reduced at the PMZ grain boundaries with grain refiner additions to fusion zone through AA5356 or AA4043

  8. Partially melted zone cracking in AA6061 welds

    Energy Technology Data Exchange (ETDEWEB)

    Prasad Rao, K. [Department of Metallurgical and Materials Engineering, Indian Institute of Technology Madras, Chennai (India)], E-mail: kpr@iitm.ac.in; Ramanaiah, N. [Sri Kalahasteeswara Institute of Technology, Srikalahasti (India); Viswanathan, N. [Defence Research and Development Laboratory, Hyderabad (India)

    2008-07-01

    Partially melted zone (PMZ) cracking susceptibility in AA6061 alloy was studied. Role of prior thermal history, gas tungsten arc welding techniques such as continuous current (CC) and pulsed current (PC) and use of different fillers (AA4043 and AA5356) were studied. Role of different grain refiners such as scandium, zirconium and Tibor in the above fillers was studied. Varestraint test was used to study the PMZ cracking susceptibility. Metallurgical analysis was done to corroborate the results. PMZ cracking was severe in T6 temper than in T4 irrespective of filler material. PMZ cracking susceptibility was more with AA5356 than in AA4043. It was less with pulsed current GTAW. PMZ cracking susceptibility was reduced with addition of grain refiners. Out of all, lowest PMZ cracking susceptibility was observed with 0.5%Sc addition to fusion zone through AA4043 filler and PC technique. The concentrations of magnesium and silicon were reduced at the PMZ grain boundaries with grain refiner additions to fusion zone through AA5356 or AA4043.

  9. Insights into Alternanthera mosaic virus TGB3 functions: Interactions with Nicotiana benthamiana PsbO correlate with chloroplast vesiculation and veinal necrosis caused by TGB3 overexpression

    Science.gov (United States)

    Alternanthera mosaic virus (AltMV) triple gene block 3 (TGB3) protein is involved in viral movement. AltMV TGB3 subcellular localization was previously shown to be distinct from that of Potato virus X (PVX) TGB3, and a chloroplast binding domain identified; veinal necrosis and chloroplast vesiculati...

  10. Anglocentrisk guide til klassisk musik

    DEFF Research Database (Denmark)

    Bonde, Lars Ole

    2009-01-01

    Kritisk anmeldelse af dansk bearbejdet udgave af den engelske originaludgivelse. Den kritiserers bl.a. for at have alt for lidt dansk/nordisk musik med.......Kritisk anmeldelse af dansk bearbejdet udgave af den engelske originaludgivelse. Den kritiserers bl.a. for at have alt for lidt dansk/nordisk musik med....

  11. Neural correlate of autistic-like traits and a common allele in the oxytocin receptor gene.

    Science.gov (United States)

    Saito, Yuki; Suga, Motomu; Tochigi, Mamoru; Abe, Osamu; Yahata, Noriaki; Kawakubo, Yuki; Liu, Xiaoxi; Kawamura, Yoshiya; Sasaki, Tsukasa; Kasai, Kiyoto; Yamasue, Hidenori

    2014-10-01

    Sub-clinical autistic-like traits (ALTs) are continuously distributed in the general population and genetically linked to autism. Although identifying the neurogenetic backgrounds of ALTs might enhance our ability to identify those of autism, they are largely unstudied. Here, we have examined the neuroanatomical basis of ALTs and their association with the oxytocin receptor gene (OXTR) rs2254298A, a known risk allele for autism in Asian populations which has also been implicated in limbic-paralimbic brain structures. First, we extracted a four-factor structure of ALTs, as measured using the Autism-Spectrum Quotient, including 'prosociality', 'communication', 'details/patterns' and 'imagination' in 135 neurotypical adults (79 men, 56 women) to reduce the genetic heterogeneity of ALTs. Then, in the same population, voxel-based morphometry revealed that lower 'prosociality', which indicates strong ALTs, was significantly correlated to smaller regional grey matter volume in the right insula in males. Males with lower 'prosociality' also had less interregional structural coupling between the right insula and the ventral anterior cingulate cortex. Furthermore, males with OXTR rs2254298A had significantly smaller grey matter volume in the right insula. These results show that decreased volume of the insula is a neuroanatomical correlate of ALTs and a potential intermediate phenotype linking ALTs with OXTR in male subjects. © The Author (2013). Published by Oxford University Press. For Permissions, please email: journals.permissions@oup.com.

  12. Association of the Aspartate Aminotransferase to Alanine Aminotransferase Ratio with BNP Level and Cardiovascular Mortality in the General Population: The Yamagata Study 10-Year Follow-Up

    Directory of Open Access Journals (Sweden)

    Miyuki Yokoyama

    2016-01-01

    Full Text Available Background. Early identification of high risk subjects for cardiovascular disease in health check-up is still unmet medical need. Cardiovascular disease is characterized by the superior increase in aspartate aminotransferase (AST to alanine aminotransferase (ALT. However, the association of AST/ALT ratio with brain natriuretic peptide (BNP levels and cardiovascular mortality remains unclear in the general population. Methods and Results. This longitudinal cohort study included 3,494 Japanese subjects who participated in a community-based health check-up, with a 10-year follow-up. The AST/ALT ratio increased with increasing BNP levels. And multivariate logistic analysis showed that the AST/ALT ratio was significantly associated with a high BNP (≥100 pg/mL. There were 250 all-cause deaths including 79 cardiovascular deaths. Multivariate Cox proportional hazard regression analysis revealed that a high AST/ALT ratio (>90 percentile was an independent predictor of all-cause and cardiovascular mortality after adjustment for confounding factors. Kaplan-Meier analysis demonstrated that cardiovascular mortality was higher in subjects with a high AST/ALT ratio than in those without. Conclusions. The AST/ALT ratio was associated with an increase in BNP and was predictive of cardiovascular mortality in a general population. Measuring the AST/ALT ratio during routine health check-ups may be a simple and cost-effective marker for cardiovascular mortality.

  13. Alanine aminotransferase is associated with an adverse nocturnal blood glucose profile in individuals with normal glucose regulation.

    Directory of Open Access Journals (Sweden)

    Jian Zhou

    Full Text Available OBJECTIVE: Although the association between alanine aminotransferase (ALT levels and risk of type 2 diabetes is well-studied, the effects of slightly increased ALT levels within the normal range on the temporal normal glucose profile remains poorly understood. METHODS: A total of 322 Chinese subjects without impaired glucose tolerance or previous diagnoses of diabetes were recruited for study from 10 hospitals in urban areas across China. All subjects wore a continuous glucose monitoring (CGM system for three consecutive days. The diurnal (06∶00-20∶00 and nocturnal (20∶00-06∶00 mean blood glucose (MBG levels were calculated. Subjects were stratified by ALT quartile level and correlation analyses were performed. RESULTS: The median ALT level was 17 IU/L, and subjects with ALT ≥17 IU/L had higher nocturnal MBG level than those with ALT 0.05. Multivariate stepwise regression analysis of elevated nocturnal MBG identified increased HOMA-IR, elevated ALT levels, and decreased homeostatic model assessment of ß-cell function as independent factors (all, P<0.05. CONCLUSIONS: Mildly elevated ALT levels, within the normal range, are associated with unfavorable nocturnal glucose profiles in Chinese subjects with normal glucose regulation.

  14. Liver alanine aminotransferase, insulin resistance and endothelial dysfunction in normotriglyceridaemic subjects with type 2 diabetes mellitus

    NARCIS (Netherlands)

    Schindhelm, RK; Diamant, M; Bakker, SJL; van Dijk, RAJM; Scheffer, PG; Teerlink, T; Kostense, PJ; Heine, RJ

    Background Plasma levels of liver transaminases, including alanine aminotransferase (ALT), are elevated in most cases of nonalcoholic fatty liver disease (NAFLD). Elevated ALT levels are associated with insulin resistance, and subjects with NAFLD have features of the metabolic syndrome that confer

  15. Liver alanine aminotransferase, insulin resistance and endothelial dysfunction in normotriglyceridaemic subjects with type 2 diabetes mellitus

    NARCIS (Netherlands)

    Schindhelm, R.K.; Diamant, M.; Bakker, S.J.L.; van Dijk, R.A.; Scheffer, P.G.; Teerlink, T.; Kostense, P.J.; Heine, R.J.

    2005-01-01

    Background: Plasma levels of liver transaminases, including alanine aminotransferase (ALT), are elevated in most cases of nonalcoholic fatty liver disease (NAFLD). Elevated ALT levels are associated with insulin resistance, and subjects with NAFLD have features of the metabolic syndrome that confer

  16. Opsigtsvækkende nyt om derivater fra USA

    DEFF Research Database (Denmark)

    Thinggaard, Frank

    1997-01-01

    Der er opsigsvækkende nyt fra USA om den regnskabsmæssige behandling af derivater som terminskontrakter, futures, optioner, swaps m.v. Glem alt om historiske anskaffelsespriser. For derivater er der kun ét mål, som kan bruges: markedsværdier (fair-values). Glem alt om snakken om 'off-balance-sheet...

  17. Developing an Alternanthera mosaic virus vector for efficient clonging of Whitefly cDNA RNAi to screen gene function

    Science.gov (United States)

    Alternanthera mosaic virus (AltMV; genus Potexvirus) is distinguished from the type member of the genus, Potato virus X by features of viral movement and variation within triple gene block protein 1 (TGB1). AltMV TGB1 variants TGB1L88 and TGB1P88 confer strong and weak silencing suppression, respect...

  18. 78 FR 66105 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Science.gov (United States)

    2013-11-04

    ..., the Secretary of Defense, the Secretary of State, and the Secretary of Homeland Security may designate... found to be: (1) Materially assisting in, or providing financial or technological support for or to, or... 1965; POB Madrid, Spain; citizen Spain; alt. citizen Peru; D.N.I. 01927713-Z (Spain); alt. D.N.I...

  19. Optimal cut?off value of alanine aminotransferase level to precisely estimate the presence of fatty liver in patients with poorly controlled type?2 diabetes

    OpenAIRE

    Tanabe, Akihito; Tatsumi, Fuminori; Okauchi, Seizo; Yabe, Hiroki; Tsuda, Tomohiro; Okutani, Kazuma; Yamashita, Kazuki; Nakashima, Koji; Kaku, Kohei; Kaneto, Hideaki

    2016-01-01

    Optimal cut?off value of ALT level to precisely estimate the presence of fatty liver was as low as 28.0?U/L. We should consider the possibility of fatty liver even when ALT level is within normal range in subjects with poorly controlled type 2 diabetes.

  20. Drømmebilleder

    DEFF Research Database (Denmark)

    Fausing, Bent

    2014-01-01

    Bogen beskriver i en række intense analyser forbindelsen mellem ydre og indre billeder: altså mellem de moderne mediers billedverden og drømmens og erindringens indre billeder. I fokus for undersøgelsen er desuden kønnet, altså hvordan billeder viser, omformer eller skjuler kønnet, 'det andet', s...

  1. Oropharyngeal Dysphagia Is Strongly Correlated With Apparent Life-Threatening Events.

    Science.gov (United States)

    Duncan, Daniel R; Amirault, Janine; Mitchell, Paul D; Larson, Kara; Rosen, Rachel L

    2017-08-01

    The aim of the present study was to investigate the prevalence of oropharyngeal dysfunction with resultant aspiration in patients admitted after apparent life-threatening events (ALTE) and to determine whether historical characteristics could predict this oropharyngeal dysphagia and aspiration risk. We retrospectively reviewed the records of all patients admitted to Boston Children's Hospital between 2012 and 2015 with a diagnosis of ALTE to determine the frequency of evaluation for oropharyngeal dysphagia using video fluoroscopic swallow studies (VFSS) and clinical feeding evaluations, to determine the prevalence of swallowing dysfunction in subjects admitted after ALTE and to compare presenting historical characteristics to swallow study results. A total of 188 children were admitted with a diagnosis of ALTE of which 29% (n = 55) had an assessment of swallowing by VFSS. Of those who had a VFSS, 73% (n = 40) had evidence of aspiration or penetration on VFSS. Of all of the diagnostic tests ordered on patients with ALTEs, the VFSS had the highest rate of abnormalities of any test ordered. None of the historical characteristics of ALTE predicted which patients were at risk for aspiration. In patients who had both clinical feeding evaluations and VFSS, observed clinical feedings incorrectly identified 26% of patients as having no oropharyngeal dysphagia when in fact aspiration was present on VFSS. Oropharyngeal dysphagia with aspiration is the most common diagnosis identified in infants presenting with ALTEs. The algorithm for ALTE should be revised to include an assessment of VFSS as clinical feeding evaluations are inadequate to assess for aspiration.

  2. Kommunikationskritisk kompetence

    DEFF Research Database (Denmark)

    Bundsgaard, Jeppe

    2008-01-01

    Sprogundervisningen i danskfaget har alt for længe handlet alt for meget om grammatik. Udbyttet står slet ikke mål med indsatsen, så hvorfor ikke bruge tiden på noget fornuftigt? I denne artikel gives et forslag til hvordan sprogundervisningen kan blive relevant og gøre en forskel i elevernes udv...

  3. Variability in alternanthera mosaic virus isolates from different hosts

    Science.gov (United States)

    We have determined the complete genome sequences of Alternanthera mosaic virus phlox isolate PA (AltMV-PA) and four infectious clone variants derived from AltMV-SP, as well as partial sequences of other isolates from various types of phlox, and from portulaca, nandina, and cineraria. Phylogenetic co...

  4. Correlation between alanine aminotransferase level, HCV-RNA titer ...

    African Journals Online (AJOL)

    In contrast, an insignificant correlation was found between ALT level and grade of necroinflammation. In conclusion neither ALT level nor HCV viremia can reflect the histological liver change accurately. As a result, liver biopsy or other noninvasive procedures that measure liver stiffness (i.e., Fibroscan) remain essential for ...

  5. 77 FR 41477 - Designation of 2 Individuals and 2 Entities Pursuant to Executive Order 13224 of September 23...

    Science.gov (United States)

    2012-07-13

    ... security, foreign policy, or economy of the United States; (3) persons determined by the Director of OFAC... Province, Afghanistan; Sarafi Market, Farah, Afghanistan; Dubai, United Arab Emirates; Zahedan, Iran; Zabul, Iran; Tax ID No. 1774308 (Pakistan); alt. Tax ID No. 0980338 (Pakistan); alt. Tax ID No. 3187777...

  6. Kan diplomstuderende læse en peer-reviewet artikel i den første uge?

    DEFF Research Database (Denmark)

    Jørgensen, Anker Helms

    2014-01-01

    % skrev et abstract, 96% fandt brugen i første uge acceptabel og 100 % men- te, at øvelsen skulle gentages i næste semester. De studerende værdsatte artiklens autenticitet; de fandt det nyttigt og udfordrende at skrive tidligt; skrivningen fik dem til at tænke. Alt i alt var det en succesoplevelse, som...

  7. Prevalence and predictors of alanine aminotransferase elevation among normal weight, overweight and obese youth in Mexico.

    Science.gov (United States)

    Purcell, Maura; Flores, Yvonne N; Zhang, Zuo-Feng; Denova-Gutiérrez, Edgar; Salmeron, Jorge

    2013-09-01

    This study aimed to determine the prevalence of and risk factors associated with elevated alanine aminotransferase (ALT) levels among a sample of normal weight, overweight and obese youth from two urban populations in Central Mexico. Baseline data from 1262 youth aged 8-19 years who participated in the Mexican Health Worker Cohort Study from March 2004 to April 2006 were reviewed, including 680 girls and 582 boys, with a total of 83 participants with elevated ALT level (>40 U/L). Information was obtained from self-administered questionnaires, anthropometric results and clinical measurements. Associations of interest were examined using multivariate logistic regression models. A total of 3.8% of girls and 9.8% of boys had elevated ALT levels. Elevated ALT was observed in 28.9% of the obese and 14.2% of the overweight participants. Metabolic syndrome (MS) occurred in 6.1% of the study population and those with MS had a high percentage of elevated ALT (14.5% of girls and 40.0% of boys, respectively). Abdominal obesity and insulin resistance were also associated with a greater risk of elevated ALT. Obesity and certain metabolic risk factors are important predictors for elevated ALT. Screening for ALT levels in obese youth could help to identify those at risk and reduce the possibility of future liver diseases. © 2013 Wiley Publishing Asia Pty Ltd and Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine.

  8. 76 FR 17987 - Supplemental Identification Information of One Individual Designated Pursuant to Executive Order...

    Science.gov (United States)

    2011-03-31

    .... nationals or the national security, foreign policy, or economy of the United States; (3) persons determined..., Indonesia; DOB 17 Aug 1957; alt. DOB 17 Aug 1958; POB Korleko-Lombok Timur, Indonesia; alt. POB Tirpas- Selong Village, East Lombok, Indonesian; nationality Indonesia; National ID No. 3603251708570001...

  9. Lad os få intelligente målinger

    DEFF Research Database (Denmark)

    Andersen, Vibeke; Nielsen, Flemming Kjeld

    2009-01-01

    Når målerlarven stiller sin appetit ædes alt det grønne og bløde, og alt hvad der lades tilbage er bladenes afpillede skelet. Er det samme ved at ske i det moderne arbejdsliv? Vores arbejde bliver registreret ned i mindste detalje på tid, effektivitet og performance og meldt tilbage i uoverskueli...

  10. The Education and Training of Learning Technologists: A Competences Approach (Report to IEEE Technical Committee on Learning Technologies)

    Science.gov (United States)

    Hartley, Roger; Kinshuk; Koper, Rob; Okamoto, Toshio; Spector, J. Michael

    2010-01-01

    The educational and training requirements of Advanced Learning Technology (ALT) need to engage with curricula that reflect the varied requirements of the workplace and of society. Students have a range of interests and ambitions in ALT which the instructional process has to accommodate and support. With these considerations in mind the IEEE…

  11. 77 FR 56271 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Science.gov (United States)

    2012-09-12

    ... identified by the President. In addition, the Secretary of the Treasury, in consultation with the Attorney..., Fraccionamiento Colinas de San Miguel, Culiacan, Sinaloa, Mexico; DOB 19 Aug 1959; alt. DOB 30 Dec 1966; POB Sinaloa, Mexico; nationality Mexico; citizen Mexico; C.U.R.P. LOPG590819MSLPRR04 (Mexico); alt. C.U.R.P...

  12. Prevalence of hepatitis A viral RNA and antibodies among Chinese blood donors.

    Science.gov (United States)

    Sun, P; Su, N; Lin, F Z; Ma, L; Wang, H J; Rong, X; Dai, Y D; Li, J; Jian, Z W; Tang, L H; Xiao, W; Li, C Q

    2015-12-09

    Like other developing countries, China was reported to have a relatively high seroprevalence of anti-hepatitis A antibodies (anti-HAV). However, no studies have evaluated the prevalence of anti-HAV and HAV RNA among voluntary blood donors with or without elevated serum alanine transaminase (ALT) levels. Anti-HAV antibodies were detected using an enzyme-linked immunosorbent assay, and reverse transcription quantitative polymerase chain reaction was carried out for detection of HAV RNA. In the current study, we analyzed a total of 450 serum samples with elevated ALT levels (≥40 U/L) and 278 serum samples with non-elevated ALT levels. Seroprevalence rates of anti-HAV were 51.6% in donors with elevated ALT and 41.4% in donors with non-elevated ALT; however, none of the samples was positive for HAV RNA. The results of our study showed lower seroprevalence rates of anti-HAV in blood donors (irrespective of ALT levels) than those in published data on Chinese populations. Although donors with elevated ALT had statistically higher prevalence rates of anti- HAV than did those with non-elevated ALT, none of the serum samples had detectable levels of the active virus. In conclusion, our results demonstrate that the transmission of hepatitis A by blood transfusion will occur rarely.

  13. Biometry | Division of Cancer Prevention

    Science.gov (United States)

    [[{"fid":"66","view_mode":"default","fields":{"format":"default","field_file_image_alt_text[und][0][value]":"Biometry Research Group Homepage Logo","field_file_image_title_text[und][0][value]":"Biometry Research Group Homepage Logo","field_folder[und]":"15"},"type":"media","attributes":{"alt":"Biometry Research Group Homepage Logo","title":"Biometry Research Group Homepage

  14. Unusual Emission of Polystyrene-Based Alternating Copolymers Incorporating Aminobutyl Maleimide Fluorophore-Containing Polyhedral Oligomeric Silsesquioxane Nanoparticles

    Directory of Open Access Journals (Sweden)

    Mohamed Gamal Mohamed

    2017-03-01

    Full Text Available In this study, we synthesized an unusual 2-aminobutyl maleimide isobutyl polyhedral oligomeric silsesquioxane (MIPOSS-NHBu monomer lacking conventional fluorescent groups. We then prepared poly(styrene-alt-2-aminobutyl maleimide isobutyl POSS [poly(S-alt-MIPOSS-NHBu] and poly(4-acetoxystyrene-alt-2-aminobutyl maleimide isobutyl POSS [poly(AS-alt-MIPOSS-NHBu] copolymers through facile free radical copolymerizations using azobisisobutyronitrile as the initiator and tetrahydrofuran as the solvent. A poly(4-hydroxystyrene-alt-2-aminobutyl maleimide isobutyl POSS [poly(HS-alt-MIPOSS-NHBu] copolymer was prepared through acetoxyl hydrazinolysis of poly(AS-alt-MIPOSS-NHBu. We employed 1H, 13C, and 29Si nuclear magnetic resonance spectroscopy; Fourier transform infrared spectroscopy; differential scanning calorimetry; and photoluminescence spectroscopy to investigate the structures and the thermal and optical properties of the monomers and novel POSS-containing alternating copolymers. Intramolecular hydrogen bonding between the amino and dihydrofuran-2,5-dione group and clustering of the locked C=O groups from the POSS nanoparticles in the MIPOSS-NHBu units restricted the intramolecular motion of the polymer chain, causing it to exhibit strong light emission. As a result, the MIPOSS-NHBu monomer and the poly(AS-alt-MIPOSS-NHBu copolymer both have potential applicability in the detection of metal ions with good selectivity.

  15. 75 FR 11749 - Fisheries of the Exclusive Economic Zone Off Alaska; Gulf of Alaska; Final 2010 and 2011 Harvest...

    Science.gov (United States)

    2010-03-12

    ...: Effective at 1200 hrs, Alaska local time (A.l.t.), March 12, 2010, through 2400 hrs, A.l.t., December 31...). The apportionment of TAC amounts among gear types, processing sectors, and seasons is discussed below... data reflecting catch-per-unit-effort provides rational input for stock distribution assessments. NMFS...

  16. 76 FR 11111 - Fisheries of the Exclusive Economic Zone Off Alaska; Gulf of Alaska; Final 2011 and 2012 Harvest...

    Science.gov (United States)

    2011-03-01

    ... local time (A.l.t.), March 1, 2011, through 2400 hrs, A.l.t., December 31, 2012. ADDRESSES: Electronic... apportionment of TAC amounts among gear types, processing sectors, and seasons is discussed below. Tables 1 and... fishery data reflecting catch-per-unit-effort provides rational input for stock distribution assessments...

  17. Marine Text Forecasts and Products Listing

    Science.gov (United States)

    FQPZ23KWNO West Coast 06z, 18z FQAC23KWNO Artic Alaska 06z, 18z Computer-generated extratropical storm surge Water Levels Tsunami Coastal/Lakeshore Hazard Message; Storm Surge Forecasts Satellite Orbit Predictions Update (Storm #1) As required TCUAT2 (alt) Tropical Cyclone Update (Storm #2) As required TCUAT3 (alt

  18. Barrier and adhesion properties of anti-corrosion coatings based on surfactant-free latexes from anhydride-containing polymers

    NARCIS (Netherlands)

    Soer, W.J.; Ming, W.; Koning, C.E.; Benthem, van R.A.T.M.; Mol, J.M.C.; Terryn, H.

    2009-01-01

    We have successfully obtained surfactant-free latexes from anhydride-containing polymers, including poly(styrene-alt-maleic anhydride) (PSMA), maleinized polybutadiene (PBDMA), and poly(octadecene-alt-maleic anhydride) (POMA). Here we report barrier and adhesion properties of the coatings made from

  19. NCBI nr-aa BLAST: CBRC-MLUC-01-0873 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MLUC-01-0873 ref|NP_997055.1| G protein-coupled receptor for asthma susceptibi...rotein coupled receptor 154; AltName: Full=G-protein coupled receptor for asthma susceptibility; AltName: Fu

  20. NCBI nr-aa BLAST: CBRC-STRI-01-1655 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-STRI-01-1655 ref|NP_997055.1| G protein-coupled receptor for asthma susceptibi...rotein coupled receptor 154; AltName: Full=G-protein coupled receptor for asthma susceptibility; AltName: Fu

  1. NCBI nr-aa BLAST: CBRC-GGOR-01-1168 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-GGOR-01-1168 ref|NP_997055.1| G protein-coupled receptor for asthma susceptibi...rotein coupled receptor 154; AltName: Full=G-protein coupled receptor for asthma susceptibility; AltName: Fu

  2. NCBI nr-aa BLAST: CBRC-MMUR-01-1230 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MMUR-01-1230 ref|NP_997055.1| G protein-coupled receptor for asthma susceptibi...rotein coupled receptor 154; AltName: Full=G-protein coupled receptor for asthma susceptibility; AltName: Fu

  3. NCBI nr-aa BLAST: CBRC-MDOM-06-0132 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MDOM-06-0132 ref|NP_997055.1| G protein-coupled receptor for asthma susceptibi...rotein coupled receptor 154; AltName: Full=G-protein coupled receptor for asthma susceptibility; AltName: Fu

  4. NCBI nr-aa BLAST: CBRC-PCAP-01-1569 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-PCAP-01-1569 ref|NP_997055.1| G protein-coupled receptor for asthma susceptibi...rotein coupled receptor 154; AltName: Full=G-protein coupled receptor for asthma susceptibility; AltName: Fu

  5. NCBI nr-aa BLAST: CBRC-PHAM-01-0638 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-PHAM-01-0638 ref|NP_997055.1| G protein-coupled receptor for asthma susceptibi...rotein coupled receptor 154; AltName: Full=G-protein coupled receptor for asthma susceptibility; AltName: Fu

  6. NCBI nr-aa BLAST: CBRC-OPRI-01-1570 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-OPRI-01-1570 ref|NP_997055.1| G protein-coupled receptor for asthma susceptibi...rotein coupled receptor 154; AltName: Full=G-protein coupled receptor for asthma susceptibility; AltName: Fu

  7. NCBI nr-aa BLAST: CBRC-VPAC-01-1643 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-VPAC-01-1643 ref|NP_997055.1| G protein-coupled receptor for asthma susceptibi...rotein coupled receptor 154; AltName: Full=G-protein coupled receptor for asthma susceptibility; AltName: Fu

  8. Civilsamfundets ABC: R for Republikanisme

    DEFF Research Database (Denmark)

    Lund, Anker Brink; Meyer, Gitte

    2017-01-01

    Vi er nået til R for Republikanisme. Respublica er den oldgamle latinske og altså romerske betegnelse for offentlige anliggender.......Vi er nået til R for Republikanisme. Respublica er den oldgamle latinske og altså romerske betegnelse for offentlige anliggender....

  9. Beta-ureidopropionase deficiency presenting with febrile status epilepticus

    NARCIS (Netherlands)

    Assmann, Birgit E.; van Kuilenburg, Andre B. P.; Distelmaier, Felix; Abeling, Nico G. G. M.; Rosenbaum, Thorsten; Schaper, Jörg; Duran, Marinus; Mayatepek, Ertan

    2006-01-01

    Beta-ureidopropionase is the third enzyme in the catabolic pathway of uracil and thymine. To date, only three other patients are reported with this inborn error of metabolism. We report the clinical presentation of a male patient who presented at the age of 4 months after an ALTE-like event (ALTE =

  10. Telomere maintenance through recruitment of internal genomic regions.

    Science.gov (United States)

    Seo, Beomseok; Kim, Chuna; Hills, Mark; Sung, Sanghyun; Kim, Hyesook; Kim, Eunkyeong; Lim, Daisy S; Oh, Hyun-Seok; Choi, Rachael Mi Jung; Chun, Jongsik; Shim, Jaegal; Lee, Junho

    2015-09-18

    Cells surviving crisis are often tumorigenic and their telomeres are commonly maintained through the reactivation of telomerase. However, surviving cells occasionally activate a recombination-based mechanism called alternative lengthening of telomeres (ALT). Here we establish stably maintained survivors in telomerase-deleted Caenorhabditis elegans that escape from sterility by activating ALT. ALT survivors trans-duplicate an internal genomic region, which is already cis-duplicated to chromosome ends, across the telomeres of all chromosomes. These 'Template for ALT' (TALT) regions consist of a block of genomic DNA flanked by telomere-like sequences, and are different between two genetic background. We establish a model that an ancestral duplication of a donor TALT region to a proximal telomere region forms a genomic reservoir ready to be incorporated into telomeres on ALT activation.

  11. A phase I study evaluating the pharmacokinetics, safety and tolerability of an antibody-based tissue factor antagonist in subjects with acute lung injury or acute respiratory distress syndrome

    Directory of Open Access Journals (Sweden)

    Morris Peter E

    2012-02-01

    Full Text Available Abstract Background The tissue factor (TF-dependent extrinsic pathway has been suggested to be a central mechanism by which the coagulation cascade is locally activated in the lungs of patients with acute lung injury and acute respiratory distress syndrome (ALI/ARDS and thus represents an attractive target for therapeutic intervention. This study was designed to determine the pharmacokinetic and safety profiles of ALT-836, an anti-TF antibody, in patients with ALI/ARDS. Methods This was a prospective, randomized, placebo-controlled, dose-escalation Phase I clinical trial in adult patients who had suspected or proven infection, were receiving mechanical ventilation and had ALI/ARDS (PaO2/FiO2 ≤ 300 mm. Eighteen patients (6 per cohort were randomized in a 5:1 ratio to receive ALT-836 or placebo, and were treated within 48 hours after meeting screening criteria. Cohorts of patients were administered a single intravenously dose of 0.06, 0.08 or 0.1 mg/kg ALT-836 or placebo. Blood samples were taken for pharmacokinetic and immunogenicity measurements. Safety was assessed by adverse events, vital signs, ECGs, laboratory, coagulation and pulmonary function parameters. Results Pharmacokinetic analysis showed a dose dependent exposure to ALT-836 across the infusion range of 0.06 to 0.1 mg/kg. No anti-ALT-836 antibody response was observed in the study population during the trial. No major bleeding episodes were reported in the ALT-836 treated patients. The most frequent adverse events were anemia, observed in both placebo and ALT-836 treated patients, and ALT-836 dose dependent, self-resolved hematuria, which suggested 0.08 mg/kg as an acceptable dose level of ALT-836 in this patient population. Conclusions Overall, this study showed that ALT-836 could be safely administered to patients with sepsis-induced ALI/ARDS. Trial registration ClinicalTrials.gov: NCT01438853

  12. Association between Serum Uric Acid and Elevated Alanine Aminotransferase in the General Population.

    Science.gov (United States)

    Chen, Shuang; Guo, Xiaofan; Yu, Shasha; Sun, Guozhe; Yang, Hongmei; Li, Zhao; Sun, Yingxian

    2016-08-24

    Both the serum uric acid (SUA) level and elevated alanine aminotransferase (ALT) are related to metabolic syndrome. However, the association between SUA and elevated ALT has not been elucidated in the general population. The objective of this study was to investigate the association between SUA and elevated ALT in the general population of China; A total of 11,572 adults (≥35 years of age) participated in this survey. Elevated ALT was defined as >40 U/L. SUA ≥ 7.0 mg/dL in males or ≥6.0 mg/dL in females was defined as hyperuricemia. SUA within the reference range was divided into quartiles, and its associations with elevated ALT were evaluated by logistic regressions; A total of 7.4% participants had elevated ALT. The prevalence of hyperuricemia was 14.9% in males and 7.3% in females. There was a significantly positive dose-response association between SUA levels and the prevalence of elevated ALT. After adjusting for potential confounders, a positive relationship for elevated ALT was observed in subjects with hyperuricemia (odds ratio [OR]: 2.032, 95% confidence interval [CI]: 1.443-2.861 for men; OR: 2.045, 95% CI: 1.221-3.425 for women, both p < 0.05). Within the reference range, the association between SUA and elevated ALT persisted in the fourth quartile (OR: 1.467, 95% CI: 1.063-2.025 for men; OR: 1.721, 95% CI: 1.146-2.585 for women, both p < 0.05); Our results indicated that an increased SUA level, even within the reference range, was independently associated with elevated ALT in Chinese adults.

  13. Risk factors for delayed healing at the free anterolateral thigh flap donor site

    Directory of Open Access Journals (Sweden)

    Yoshiro Abe

    2018-01-01

    Full Text Available Background The free anterolateral thigh (ALT flap has been widely used for various kinds of reconstructions. However, delayed healing at the donor site occasionally occurs due to wound dehiscence or the partial loss of grafted skin at the donor site. The aim of the present study was to identify reliable predictive factors for delayed healing at the donor site after the harvest of a free ALT flap. Methods This study included 52 patients who underwent reconstructive procedures using free ALT flaps. The delayed healing group included patients with wounds at the donor site that had not healed over 3 weeks after surgery, and the normal healing group included patients who showed wound healing within 3 weeks after surgery. Multivariate logistic regression models were created to identify the risk factors for delayed healing at the ALT flap donor site. Results Among the 52 patients, 24 (46.2% showed delayed healing at the donor site, and 6 patients required additional operative treatment. A high preoperative body mass index (BMI, smoking, and skin grafting were found to be significantly associated with delayed healing at the ALT donor site. Of the 37 patients who underwent skin grafting, 23 (62% experienced delayed healing at the donor site. Conclusions A high preoperative BMI, smoking, and skin grafting were risk factors for delayed healing at the free ALT donor site. Skin grafting at the ALT donor site should be avoided in patients with a high BMI or a habit of smoking.

  14. The roles of WRN and BLM RecQ helicases in the Alternative Lengthening of Telomeres.

    Science.gov (United States)

    Mendez-Bermudez, Aaron; Hidalgo-Bravo, Alberto; Cotton, Victoria E; Gravani, Athanasia; Jeyapalan, Jennie N; Royle, Nicola J

    2012-11-01

    Approximately 10% of all cancers, but a higher proportion of sarcomas, use the recombination-based alternative lengthening of telomeres (ALT) to maintain telomeres. Two RecQ helicase genes, BLM and WRN, play important roles in homologous recombination repair and they have been implicated in telomeric recombination activity, but their precise roles in ALT are unclear. Using analysis of sequence variation present in human telomeres, we found that a WRN- ALT+ cell line lacks the class of complex telomere mutations attributed to inter-telomeric recombination in other ALT+ cell lines. This suggests that WRN facilitates inter-telomeric recombination when there are sequence differences between the donor and recipient molecules or that sister-telomere interactions are suppressed in the presence of WRN and this promotes inter-telomeric recombination. Depleting BLM in the WRN- ALT+ cell line increased the mutation frequency at telomeres and at the MS32 minisatellite, which is a marker of ALT. The absence of complex telomere mutations persisted in BLM-depleted clones, and there was a clear increase in sequence homogenization across the telomere and MS32 repeat arrays. These data indicate that BLM suppresses unequal sister chromatid interactions that result in excessive homogenization at MS32 and at telomeres in ALT+ cells.

  15. Trends in glaucoma surgery incidence and reimbursement for physician services in the Medicare population from 1995 to 1998.

    Science.gov (United States)

    Paikal, David; Yu, Fei; Coleman, Anne L

    2002-07-01

    To better understand the relationship between glaucoma management and economic incentives, we examined the volume and the reimbursement of argon laser trabeculoplasty (ALT) and trabeculectomy in a 5% random sample of the Medicare population from 1995 to 1998. Retrospective cohort study. Subjects in a 5% random sample of the Medicare population who had ALT and trabeculectomy from 1995 to 1998. Using the Health Care Financing Administration (HCFA) Physician/Supplier Part-B files for a 5% random sample of the Medicare population, we identified all subjects who had ALT and trabeculectomy from 1995 to 1998. Descriptive summaries (the number of surgeries and the mean and the standard deviation of reimbursement per surgery) were calculated for each year. Analysis of variance was used to test for differences in reimbursement per surgery across years. Chi-square tests were used to assess any associations between the changing numbers of ALTs and trabeculectomies over the study period and both age and race. We assessed the number of ALTs and trabeculectomies and the allowed charges for each surgery in the 5% random sample of the Medicare population from 1995 to 1998. The volume of both ALTs and trabeculectomies declined during the study period. Reimbursement per surgery for both ALT and trabeculectomy varied significantly across years (P management of glaucoma, among other factors.

  16. Remotely Sensed Active Layer Thickness (ReSALT at Barrow, Alaska Using Interferometric Synthetic Aperture Radar

    Directory of Open Access Journals (Sweden)

    Kevin Schaefer

    2015-03-01

    Full Text Available Active layer thickness (ALT is a critical parameter for monitoring the status of permafrost that is typically measured at specific locations using probing, in situ temperature sensors, or other ground-based observations. Here we evaluated the Remotely Sensed Active Layer Thickness (ReSALT product that uses the Interferometric Synthetic Aperture Radar technique to measure seasonal surface subsidence and infer ALT around Barrow, Alaska. We compared ReSALT with ground-based ALT obtained using probing and calibrated, 500 MHz Ground Penetrating Radar at multiple sites around Barrow. ReSALT accurately reproduced observed ALT within uncertainty of the GPR and probing data in ~76% of the study area. However, ReSALT was less than observed ALT in ~22% of the study area with well-drained soils and in ~1% of the area where soils contained gravel. ReSALT was greater than observed ALT in some drained thermokarst lake basins representing ~1% of the area. These results indicate remote sensing techniques based on InSAR could be an effective way to measure and monitor ALT over large areas on the Arctic coastal plain.

  17. The Role of the Distal Runoff Vessel of the Descending Branch of the Lateral Circumflex Femoral System in Anterolateral Thigh Flap Surgery: A Case Series and Literature Review.

    Science.gov (United States)

    He, Xiao-Qing; Zhu, Yue-Liang; Wang, Yi; Mei, Liang-Bin; Jin, Tao; Xu, Yong-Qing

    2016-01-01

    As a distal portion of the descending branch of the lateral circumflex femoral system (LCFS), the role of the distal runoff vessel in anterolateral thigh (ALT) flap surgery has long been overlooked. Recently, however, the distal runoff vessel has been increasingly used in many aspects of ALT flap surgery, and it has exhibited superior properties in solving some difficult problems. Fourteen ALT flaps using the distal runoff vessel of the descending branch of the LCFS for extremity defects were retrospectively reviewed, and recent reports on using the distal runoff vessel were reviewed to determine the role of this vessel in ALT flap surgery. In our series, the distal runoff vessel was used as a flow-through pattern in 10 cases, as a recombined chimeric flap in 2 cases, and as a backup vessel for flap salvage in 2 cases. All of the ALT flaps completely survived. None of the donor sites presented with additional morbidity as a result of harvesting the distal runoff vessel. In the literature review, the following are 5 other options for using the distal runoff vessel: in interposition artery and vein grafts, as the pedicle of the reverse-flow ALT flap, as the recipient vessel, to avoid twisting, and as a monitoring method. The distal runoff vessel of the descending branch of the LCFS could be used for many aspects of the ALT flap surgery, and this vessel plays an irreplaceable role in some difficult reconstruction surgeries.

  18. Phosphorylation inhibits DNA-binding of alternatively spliced aryl hydrocarbon receptor nuclear translocator

    International Nuclear Information System (INIS)

    Kewley, Robyn J.; Whitelaw, Murray L.

    2005-01-01

    The basic helix-loop-helix/PER-ARNT-SIM homology (bHLH/PAS) transcription factor ARNT (aryl hydrocarbon receptor nuclear translocator) is a key component of various pathways which induce the transcription of cytochrome P450 and hypoxia response genes. ARNT can be alternatively spliced to express Alt ARNT, containing an additional 15 amino acids immediately N-terminal to the DNA-binding basic region. Here, we show that ARNT and Alt ARNT proteins are differentially phosphorylated by protein kinase CKII in vitro. Phosphorylation had an inhibitory effect on DNA-binding to an E-box probe by Alt ARNT, but not ARNT, homodimers. This inhibitory phosphorylation occurs through Ser77. Moreover, a point mutant, Alt ARNT S77A, shows increased activity on an E-box reporter gene, consistent with Ser77 being a regulatory site in vivo. In contrast, DNA binding by an Alt ARNT/dioxin receptor heterodimer to the xenobiotic response element is not inhibited by phosphorylation with CKII, nor does Alt ARNT S77A behave differently from wild type Alt ARNT in the context of a dioxin receptor heterodimer

  19. Serum Alanine Aminotransferase Levels within Normal Range Have Different Associations with Augmentation Index and Other Cardiometabolic Risk Factors in Nondrinkers and Drinkers: A Chinese Community-Based Analysis

    Directory of Open Access Journals (Sweden)

    Shihui Fu

    2017-01-01

    Full Text Available Background. To investigate whether serum alanine aminotransferase (ALT levels within normal range were associated with augmentation index (AIx and cardiometabolic risk factors in nondrinkers and drinkers in Chinese community-dwelling population. Methods. There were 4165 participants with serum ALT levels within normal range. Results. Alcohol drinking was observed in 1173 participants (28.2%. In multivariate analysis, serum ALT levels of nondrinkers were independently associated with age, sex, body mass index (BMI, hypertension, diabetes mellitus, diastolic blood pressure, triglyceride, low-density lipoprotein-cholesterol (LDL-c, and AIx, while serum ALT levels of drinkers were independently associated with age, sex, BMI, triglyceride, and LDL-c (p<0.05 for all. Conclusions. Associations of serum ALT levels within normal range with age, sex, body height and weight, and blood lipid were simultaneously present in participants with and without alcohol drinking, while associations of serum ALT levels within normal range with AIx, blood pressure, and glucose were seen in nondrinkers rather than in drinkers. These findings not only provide the evidence that serum ALT levels, even within the normal range, have different associations with arteriosclerosis and cardiometabolic risk factors in nondrinkers and drinkers but also are helpful in understanding the underlying pathophysiologic mechanisms linking the hepatic function to arteriosclerosis and cardiometabolic risk factors.

  20. Alternative Lengthening of Telomeres: Recurrent Cytogenetic Aberrations and Chromosome Stability under Extreme Telomere Dysfunction

    Directory of Open Access Journals (Sweden)

    Despoina Sakellariou

    2013-11-01

    Full Text Available Human tumors using the alternative lengthening of telomeres (ALT exert high rates of telomere dysfunction. Numerical chromosomal aberrations are very frequent, and structural rearrangements are widely scattered among the genome. This challenging context allows the study of telomere dysfunction-driven chromosomal instability in neoplasia (CIN in a massive scale. We used molecular cytogenetics to achieve detailed karyotyping in 10 human ALT neoplastic cell lines.We identified 518 clonal recombinant chromosomes affected by 649 structural rearrangements. While all human chromosomes were involved in random or clonal, terminal, or pericentromeric rearrangements and were capable to undergo telomere healing at broken ends, a differential recombinatorial propensity of specific genomic regions was noted.We show that ALT cells undergo epigenetic modifications rendering polycentric chromosomes functionally monocentric, and because of increased terminal recombinogenicity, they generate clonal recombinant chromosomes with interstitial telomeric repeats. Losses of chromosomes 13, X, and 22, gains of 2, 3, 5, and 20, and translocation/deletion events involving several common chromosomal fragile sites (CFSs were recurrent. Long-term reconstitution of telomerase activity in ALT cells reduced significantly the rates of random ongoing telomeric and pericentromeric CIN. However, the contribution of CFS in overall CIN remained unaffected, suggesting that in ALT cells whole-genome replication stress is not suppressed by telomerase activation. Our results provide novel insights into ALT-driven CIN, unveiling in parallel specific genomic sites that may harbor genes critical for ALT cancerous cell growth.

  1. The Genetic Overlap of Attention-Deficit/Hyperactivity Disorder and Autistic-like Traits: an Investigation of Individual Symptom Scales and Cognitive markers.

    Science.gov (United States)

    Pinto, Rebecca; Rijsdijk, Fruhling; Ronald, Angelica; Asherson, Philip; Kuntsi, Jonna

    2016-02-01

    Attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorders (ASDs) frequently co-occur. However, due to previous exclusionary diagnostic criteria, little is known about the underlying causes of this covariation. Twin studies assessing ADHD symptoms and autistic-like traits (ALTs) suggest substantial genetic overlap, but have largely failed to take into account the genetic heterogeneity of symptom subscales. This study aimed to clarify the phenotypic and genetic relations between ADHD and ASD by distinguishing between symptom subscales that characterise the two disorders. Moreover, we aimed to investigate whether ADHD-related cognitive impairments show a relationship with ALT symptom subscales; and whether potential shared cognitive impairments underlie the genetic risk shared between the ADHD and ALT symptoms. Multivariate structural equation modelling was conducted on a population-based sample of 1312 twins aged 7-10. Social-communication ALTs correlated moderately with both ADHD symptom domains (phenotypic correlations around 0.30) and showed substantial genetic overlap with both inattention and hyperactivity-impulsivity (genetic correlation = 0.52 and 0.44, respectively). In addition to previously reported associations with ADHD traits, reaction time variability (RTV) showed significant phenotypic (0.18) and genetic (0.32) association with social-communication ALTs. RTV captured a significant proportion (24 %) of the genetic influences shared between inattention and social-communication ALTs. Our findings suggest that social-communication ALTs underlie the previously observed phenotypic and genetic covariation between ALTs and ADHD symptoms. RTV is not specific to ADHD symptoms, but is also associated with social-communication ALTs and can, in part, contribute to an explanation of the co-occurrence of ASD and ADHD.

  2. Liver histology in hepatitis C virus positive patients with normal and elevated alanine amino transferase levels

    International Nuclear Information System (INIS)

    Bhatty, S.A.; Shaikh, N.A.; Akhter, S.S.

    2009-01-01

    To compare liver histology in HCV RNA positive patients with normal and elevated Alanine Aminotransferase Level (AST). This Cohort (prospective) study was conducted at Civil Hospital Karachi from Jan 2007 to July 2007. Forty patients with positive HCV RNA were included. Their liver function tests were followed for three months. Those having normal ALT on three occasions were taken as controls and those having elevated ALT were taken as cases. Liver biopsy was performed, Specimens were reviewed by single pathologist. Scheuer's scoring for grading of inflammation and staging of fibrosis of chronic hepatitis was used. Out of Forty patients having positive HCV RNA, 14 (35%) were male and 26 (65%) were female. Mean ALT in control group was 27.3 +- 6.1mu/l, mean ALT in cases was 91.7 +- 39.95 mu/l. Mean age in controls was 34.2 +- 10.75 years and in cases was 33.6 +- 9.40 years. On histopathology, the mean grade of inflammation in controls was 1.40 +- 0.681 while in cases was 1.20 +- 0.834, which was not statistically significantly different in the two groups (p= 0.411). Similarly mean staging of fibrosis in controls was 1.20 +- 0.768 and in cases was 1.35 +- 1.348 which was also not statistically different in the two groups (p=0.668). Stage 3 and 4 fibrosis was seen only in raised ALT group and not in the controls. Patients with persistently normal ALT and elevated ALT, although had similar grading of inflammation but the fibrosis score was more in elevated ALT group. None of the patients with normal ALT had normal histology, so decision for antiviral treatment should be individualized in this group also (JPMA 59:832; 2009). (author)

  3. Evaluation of the effects of a VEGFR-2 inhibitor compound on alanine aminotransferase gene expression and enzymatic activity in the rat liver.

    Science.gov (United States)

    Fuentealba, Carmen; Bera, Monali; Jessen, Bart; Sace, Fred; Stevens, Greg J; Trajkovic, Dusko; Yang, Amy H; Evering, Winston

    2011-08-17

    Traditional assessment of drug-induced hepatotoxicity includes morphological examination of the liver and evaluation of liver enzyme activity in serum. The objective of the study was to determine the origin of drug-related elevation in serum alanine aminotransferase (ALT) activity in the absence of morphologic changes in the liver by utilizing molecular and immunohistochemical techniques. Sixteen female Sprague-Dawley rats were divided into 2 groups (control and treated, n = 4 per group) and treated rats were dosed orally twice daily (400 mg/kg/day) for 7 days with a VEGFR-2 compound (AG28262), which in a previous study caused ALT elevation without morphological changes. Serum of both treated and control animals were evaluated on day 3 of treatment and at day 8. Three separate liver lobes (caudate, right medial, and left lateral) were examined for determination of ALT tissue activity, ALT gene expression and morphological changes. ALT activity was significantly (p < 0.01) elevated on day 3 and further increased on day 8. Histologic changes or increase in TUNEL and caspase3 positive cells were not observed in the liver lobes examined. ALT gene expression in the caudate lobe was significantly up-regulated by 63%. ALT expression in the left lateral lobe was not significantly affected. Statistically significant increased liver ALT enzymatic activity occurred in the caudate (96%) and right medial (41%) lobes but not in the left lateral lobe. AG28262, a VEFG-r2 inhibitor, causes an increase in serum ALT, due in part to both gene up-regulation. Differences between liver lobes may be attributable to differential distribution of blood from portal circulation. Incorporation of molecular data, such as gene and protein expression, and sampling multiple liver lobes may shed mechanistic insight to the evaluation of hepatotoxicity.

  4. Impact of increasing alanine aminotransferase levels within normal range on incident diabetes

    OpenAIRE

    Chong-Shan Wang; Ting-Tsung Chang; Wei-Jen Yao; Shan-Tair Wang; Pesus Chou

    2012-01-01

    Abnormal alanine aminotransferase level (ALT) levels might be associated with type 2 diabetes, but whether higher ALT levels within the normal range predict the risk is unknown. Methods: We followed a community-based cohort of 3446 individuals who were ≥35 years old without diabetes and hepatitis B or C in southern Taiwan for 8 years (1997–2004) to study the risk for type 2 diabetes with different normal ALT levels. Results: Among the 337 incident diabetes cases, 16.0% were from those w...

  5. Plasma Levels of Alanine Aminotransferase in the First Trimester Identify High Risk Chinese Women for Gestational Diabetes

    OpenAIRE

    Leng, Junhong; Zhang, Cuiping; Wang, Peng; Li, Nan; Li, Weiqin; Liu, Huikun; Zhang, Shuang; Hu, Gang; Yu, Zhijie; Ma, Ronald CW; Chan, Juliana CN; Yang, Xilin

    2016-01-01

    Alanine aminotransferase (ALT) predicts type 2 diabetes but it is uncertain whether it also predicts gestational diabetes mellitus (GDM). We recruited 17359 Chinese women with ALT measured in their first trimester. At 24?28?weeks of gestation, all women underwent a 50-gram 1-hour glucose challenge test (GCT) followed by a 75-gram 2-hour oral glucose tolerance test if GCT result was ?7.8?mmol/L. Restricted cubic spline analysis was used to examine full-range risk associations of ALT levels wit...

  6. NCBI nr-aa BLAST: CBRC-STRI-01-2626 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-STRI-01-2626 sp|Q8VBS7|VN1A6_MOUSE RecName: Full=Vomeronasal type-1 receptor A...6; AltName: Full=Vomeronasal type-1 receptor A3; AltName: Full=Vomeronasal type-1 receptor A1; AltName: Full=Vomeronasa...l type-1 receptor A10 dbj|BAB79209.1| vomeronasal receptor 1 A1 [Mus musculus] dbj|BAB79210.1| vomeronasa...l receptor 1 A3 [Mus musculus] gb|AAK98772.1| vomeronasal receptor V1RA10

  7. Kunngjøringens betydning for lovers rettskraft

    OpenAIRE

    Slagsvold, Per Marius

    2006-01-01

    KUNNGJØRINGENS BETYDNING FOR LOVERS RETTSKRAFT Kandidatnr:436 Veileder: Jon Bing Leveringsfrist: 25 april 2006 Til sammen 14720 ord 25.04.2006 Innholdsfortegnelse 1 Første del av avhandlingen (Overskrift 1 / Alt-1) Feil! Bokmerke er ikke definert. 1.1 Første kapittel i første del (Overskrift 2 / Alt-2) Feil! Bokmerke er ikke definert. 1.1.1 Første underkapittel i første del (Overskrift 3 / Alt-3) Feil! Bokmerke er ikke definert. 1.1.1.1 Overskrif...

  8. Modifiable clinical and lifestyle factors are associated with elevated alanine aminotransferase levels in newly diagnosed type 2 diabetes patients

    DEFF Research Database (Denmark)

    Mor, Anil; Svensson, Elisabeth; Rungby, Jørgen

    2014-01-01

    BACKGROUND: Current literature lacks data on markers of non-alcoholic fatty liver disease (NAFLD) in newly diagnosed type 2 diabetes mellitus (T2DM) patients. We therefore, conducted a cross-sectional study to examine modifiable clinical and lifestyle factors associated with elevated alanine...... aminotransferase (ALT) levels as a marker of NAFLD in new T2DM patients. METHODS: Alanine aminotransferase levels were measured in 1026 incident T2DM patients enrolled in the nationwide Danish Centre for Strategic Research in Type 2 Diabetes (DD2) cohort. We examined prevalence of elevated ALT (>38 IU/L for women....../L (interquartile range: 22-41 IU/L) in men. Elevated ALT was found in 16% of incident T2DM patients. The risk of elevated ALT was increased in patients who were diabetes debut [adjusted prevalence ratio (aPR): 1.96, 95% confidence interval (CI): 1.15-3.33], in those with alcohol overuse (>14...

  9. Correlation between alanine aminotransferase level, HCV-RNA titer ...

    African Journals Online (AJOL)

    Reham Al Swaff

    2012-04-04

    Apr 4, 2012 ... RNA titer and/or serum ALT level in patients with chronic hepatitis C (genotype 4) infection. .... Other liver diseases such as alcoholic liver disease, non- .... Insulin resistance, obesity, and steatosis are associated with a.

  10. Effect of ethanolic leave extract of phyllantus amarus on carbon ...

    African Journals Online (AJOL)

    Peters

    (AST), alanine amino transferase (ALT), alkaline phosphate (ALP) activities, and total ... and bladder problems, diabetes and intestinal ... studies, that the Phyllanthus amarus extracts (polar .... astragalin, ellagitannins like amarinic acid and.

  11. The Seebeck coefficient of monocrystalline α-SiC and polycrystalline β-SiC measured at 300-533 K

    Science.gov (United States)

    Abu-Ageel, N.; Aslam, M.; Ager, R.; Rimai, L.

    2000-01-01

    The temperature dependence of the Seebeck coefficient of polycrystalline icons/Journals/Common/beta" ALT="beta" ALIGN="TOP"/> -SiC films deposited on quartz substrates by laser ablation and of commercially available icons/Journals/Common/alpha" ALT="alpha" ALIGN="TOP"/> -SiC wafers is reported in a temperature range of 300-533 K for the first time. The Seebeck emf of icons/Journals/Common/alpha" ALT="alpha" ALIGN="TOP"/> -SiC substrates and icons/Journals/Common/beta" ALT="beta" ALIGN="TOP"/> -SiC samples ranges between -9 µV °C-1 and -108 µV °C-1 which is higher than that of commercial Pt thermocouples.

  12. Virksomhedens potentiale ligger i kundetilfredshed og -loyalitet

    DEFF Research Database (Denmark)

    Eskildsen, Jacob Kjær; Kristensen, Kai

    2008-01-01

    Denne artikel analyserer forholdet mellem kundetilfredshed, kundeloyalitet og forretningspotentialet set i forhold til nuværende kunder. Dataene stammer fra Dansk Kundetilfredshedsindeks 2006. Her vurderede i alt cirka 2000 privetkunder dres foretrukne skadesforsikringsselskab. Med baggrund i teo...

  13. A confrontation with reality - Proceedings of the 19th Association for Learning Technology Conference

    NARCIS (Netherlands)

    Hawkridge, David; Verjans, Steven; Wilson, Gail

    2012-01-01

    Hawkridge, D., Verjans, S., & Wilson, G. (Eds.) (2012). A confrontation with reality - Proceedings of the 19th Association for Learning Technology Conference (ALT-C 2012). September, 11-14, 2012, Manchester, UK.

  14. 78 FR 20390 - Unblocking of Specially Designated Nationals and Blocked Persons Pursuant to the Foreign...

    Science.gov (United States)

    2013-04-04

    .../o NEGOCIOS INTERNACIONALES DEL ECUADOR NIDEGROUP S.A., Quito, Pichincha, Ecuador; c/o SNACK PARTY...); alt. Passport 02952296-8 (Uruguay) (individual) [SDNTK]. Entity SNACK PARTY, Los Vinedos 19 y...

  15. nvj 34 4 corrected.cdr

    African Journals Online (AJOL)

    GRAPHICS DEPT

    Brommer et al, 2001) Errors that affect the results of biochemical tests may be ... pH. Total protein and albumin. Vitamins. Lactate. Aminotransferases. (ALT and ... inappropriate container, handling, storage ... undetected failure in quality control) or.

  16. Evaluation of serum angiopoietin-II in HCV related ...

    African Journals Online (AJOL)

    Hoda A. Abd-El-Moety

    2011-08-30

    Aug 30, 2011 ... blood urea, serum creatinine, serum uric acid, ALT, AST, total and direct bilirubin ... factor, cryoglobulins31–33 and urinary albumin creatinine ratio ..... reported that VEGF stimulates increased synthesis of collage- nase by ...

  17. Influence of thiopurine methyltransferase gene polymorphism on ...

    Indian Academy of Sciences (India)

    Azza A. G. Tantawy

    2017-11-28

    Nov 28, 2017 ... Thirty-two patients were on maintenance and another 32 completed their chemotherapy. .... hepatitis and liver function tests, ALT and AST were recorded. ... C with or without neutropenia. Decrease absolute neutrophil count.

  18. Internettets DNA

    DEFF Research Database (Denmark)

    Hansted, Alfred Birkegaard

    2014-01-01

    Strengt logisk kunne man argumentere for, at overskriften er ren nonsens. Sammenstillingen mellem biologien og teknologien er derfor mest af alt et filosofisk tankeeksperiment, som giver adgang til en analogisk forståelse af internettets kerne....

  19. Aerospace Example

    Data.gov (United States)

    National Aeronautics and Space Administration — This is a textbook, created example for illustration purposes. The System takes inputs of Pt, Ps, and Alt, and calculates the Mach number using the Rayleigh Pitot...

  20. Evaluation of Moringa oleifera Leaf Extract on Alcohol-induced ...

    African Journals Online (AJOL)

    induced hepatotoxicity in rats was evaluated. Rats fed alcohol only produced significant increase in the levels of enzyme markers of tissues damage (ALT, AST and ALP), lipid peroxidation (TBARS) and decreased serum vitamin C levels ...

  1. Antidepressandid tõusev trend / Monica Raud

    Index Scriptorium Estoniae

    Raud, Monica, 1981-

    2013-01-01

    Eesti inimesed neelavad praegu vähemalt kaks korda rohkem antidepressante kui aastatuhande alguses. Miks? selgitavad psühhiaatrid Peeter Jaanson, Andres Lehtmets,Viktooria Saat, perearstid Ingrid Alt ja Riina Raudsik ning mõju kommenteerivad patsiendid

  2. Reliability design of mechanical systems a guide for mechanical and civil engineers

    CERN Document Server

    Woo, Seongwoo

    2017-01-01

    This book describes basic reliability concepts – parametric ALT plan, failure mechanism and design, and reliability testing with acceleration factor and sample size equation. A generalized life-stress failure model with a new effort concept has been derived and recommended to calculate the acceleration factor of the mechanical system. The new sample size equation with the acceleration factor has also been derived to carry out the parametric ALT. This new parametric ALT should help a mechanical/civil engineer to uncover the design parameters affecting reliability during the design process of the mechanical system. Consequently, it should help companies to improve product reliability and avoid recalls due to the product/structure failures in the field. As the improper or missing design parameters in the design phase are experimentally identified by this new reliability design method - parametric ALT, the mechanical/civil engineering system might improve in reliability by the increase in lifetime and the reduc...

  3. effect of hepatitis b virus co-infection on cd4 cell count and liver

    African Journals Online (AJOL)

    2015-03-01

    Mar 1, 2015 ... total Protein, and liver enzymes were determined using standard ... The mean serum ALT, AST and ALP of mono ... HIV positivity was diagnosed by positive reactions to ..... the colorimetric Biuret method of protein determi.

  4. Journal of Chemical Sciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    ) andMn(II) complexes of poly(methyl vinyl ether-alt-maleic anhydride). Synthesis, characterization and thermodynamic parameters. Hidayet Mazi Ali Gulpinar. Volume 126 Issue 1 January 2014 pp 239-245 ...

  5. Sardiinia kirjandus kui hea idee

    Index Scriptorium Estoniae

    2007-01-01

    Toimetuse artikkel Elsbeth Gut Bozzetti artikli "Vana maailm ja uus laine" (Alte Welt und neue Welle. - Neue Zürcher Zeitung 16.12. 2006) ning internetis avaldatud materjali põhjal. Gavino Ledda, Salvatore Satta, Salvatore Niffoi jt.

  6. Diagnostic accuracy of clinical tests for the diagnosis of hip femoroacetabular impingement/labral tear

    DEFF Research Database (Denmark)

    Reiman, M P; Goode, A P; Cook, C E

    2015-01-01

    BACKGROUND: Surgery for hip femoroacetabular impingement/acetabular labral tear (FAI/ALT) is exponentially increasing despite lacking investigation of the accuracy of various diagnostic measures. Useful clinical utility of these measures is necessary to support diagnostic imaging and subsequent...

  7. Study on the serum oxidative stress status in silicosis patients

    African Journals Online (AJOL)

    Administrator

    2011-09-07

    Sep 7, 2011 ... oxidative stress parameters were investigated in silicosis patients and controls group. 128 silicosis ... to help clinicians to further delineate the role of oxidative- stress .... in age, working duration smoking, total cholesterol, ALT,.

  8. Kas Kruuda võib Kalevi müüa? / Mirko Ojakivi, Andres Reimer

    Index Scriptorium Estoniae

    Ojakivi, Mirko

    2010-01-01

    Kalevi kommivabriku aktsiad on arestitud, Alta Capitali juhi Indrek Rahumaa hinnangul on praeguse seisuga kommivabriku müümine võimatu. Skandinaavia korporatsioonist Orkla, mis aktsiate aresti alt vabastamise korral saab Kalevi omanikuks

  9. Polymeric bicontinuous microemulsions

    DEFF Research Database (Denmark)

    Bates, F.S.; Maurer, W.W.; Lipic, P.M.

    1997-01-01

    High molecular weight block copolymers can be viewed as macromolecular surfactants when blended with thermodynamically incompatible homopolymers. This Letter describes the formation of polymeric bicontinuous microemulsions in nurtures containing a model diblock copolymer and two homopolymers. Alt...

  10. Frequency modulation system test procedure shuttle task 501 approach and landing test configuration

    Science.gov (United States)

    Doland, G. D.

    1976-01-01

    Shuttle Task 501 is an in-line task to test the performance and compatibility of radiofrequency links between the SSO and ground, and relay via a satellite. Under Shuttle Task 501 approach and landing test (ALT) phase only a limited portion of the communication and tracking (C&T) equipment is to be tested. The principal item to be tested is a frequency modulated (FM) data link. To test this RF link, an ALT FM System was designed, constructed, and the console wiring verified. A step-by-step procedure to be used to perform the ALT FM system is presented. The ALT FM system test is to be performed prior to delivery of the equipment to the Electronic Systems Test Laboratory (ESTL).

  11. 76 FR 46896 - Designation of Six Individuals Pursuant to Executive Order 13224

    Science.gov (United States)

    2011-08-03

    .... nationals or the national security, foreign policy, or economy of the United States; (3) persons determined...''); DOB 1967; nationality Syria; alt. nationality Iran; ethnicity Kurdish (individual) [SDGT] Dated: July...

  12. 78 FR 21007 - Unblocking of Specially Designated Nationals and Blocked Persons Pursuant to Executive Order 13348

    Science.gov (United States)

    2013-04-08

    ....k.a. GOODRICH, Reginald B. (Senior)); DOB 11 Nov 1952; Sr.; Former Minister for Culture, Information... 65118 (Bolivia); alt. Passport 90109052 (Israel) issued 26 Nov 1997; Owner, Exotic Tropical Timber...

  13. CHAPTER 1

    African Journals Online (AJOL)

    Dr Olaleye

    formed islet cells of Langerhans in rats administered doses ≤ 1000 mg/kg body .... respiration, skin and hair coat, salivation, lacrimation, ... quantitative measurement take place within the .... cellular enzymes ALT and AST are present in low.

  14. Some effects of simultaneous administration of crude aqueous ...

    African Journals Online (AJOL)

    The result shows that the crude aqueous extract of mango levels has adverse effect on the morphology and some hepatic enzyme ... Keywords: Mango leaves, Tetracycline, Liver histology, Liver enzymes (AST and ALT) ... HOW TO USE AJOL.

  15. Фабрику Kalev продают норвежской фирме / Андрус Карнау, Райго Неудорф

    Index Scriptorium Estoniae

    Карнау, Андрус

    2010-01-01

    AS-i Kalev Chocolate Factory osta sooviv Orkla kontrerni esindajate kinnitusel hakatakse edaspidi toodangut eksportima nii Balti- kui Põhjamaadesse. Enne varade üleminekut uuele omanikule tuleb ära oodata Kalevi aktsiate aresti alt vabanemine

  16. Kalevi uus omanik tahab ettevõtte eksportima panna / Raigo Neudorf ; kommenteerinud Kuldar Leis, Kati Kusmin, Vjatšeslav Leedo

    Index Scriptorium Estoniae

    Neudorf, Raigo

    2010-01-01

    AS-i Kalev Chocolate Factory osta sooviv Orkla kontrerni esindajate kinnitusel hakatakse edaspidi toodangut eksportima nii Balti- kui Põhjamaadesse. Enne varade üleminekut uuele omanikule tuleb ära oodata Kalevi aktsiate aresti alt vabanemine. Diagramm

  17. Safety and efficacy of a Labisia pumila var alata water extract on ...

    African Journals Online (AJOL)

    kgk-002

    2014-02-05

    Feb 5, 2014 ... Future research should focus on older subjects that are sexually ... large population-based study on adults ranging from ages ... Abbreviations: LP, Labisia pumila; FSFI, female sexual function index; AEs, adverse events; ALT, ...

  18. Journal of Chemical Sciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    ... and biodegradable heterogeneous catalyst for selective aerobic oxidation of alkyl arenes and alcohols ... via Hartwig-Buchwald Amination Reaction .... Preparation of Poly(MA-alt--olefin-C6,8,12,18)/Silica Nanohybrids via in situ generated ...

  19. Alles Leben ist Problemlösen: Zum 100. Geburtstag von Karl Raimund Popper

    OpenAIRE

    Kirchgässner, Gebhard

    2002-01-01

    Karl Popper wäre im Juli 2002 hundert Jahre alt geworden. Prof. Dr. Gebhard Kirchgässner würdigt den politischen Philosophen, der als bedeutendster Wissenschaftstheoretiker des 20. Jahrhunderts gilt.

  20. Dostojevskilik kapseldunud elu Q-teatris / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres

    1997-01-01

    Fjodor Dostojevski jutustuse 'Ülestähendusi põranda alt' järgi tehtud Soome Q-teatri lavastusest 'Kelder' ("Kellari", dramatiseerinud Antti Hietala, Hannu Kivioja ja Erik Söderblom, lav. Erik Söderblom)

  1. Effect of cypermethrin toxicity on enzyme activities in the freshwater ...

    African Journals Online (AJOL)

    ALT) and glutamate dehydrogenase (GDH) were increased in all the tissues with an increase in exposure time of cypermethrin. Though, under sublethal concentration of cypermethrin for 14, 21 and 28 days, a decreasing trend was observed in all ...

  2. Effects of thyroid dysfunction-induced liver oxidative

    African Journals Online (AJOL)

    Unicornis

    were randomly divided into four groups of six each: the first group served as a ... significant increase in plasmatic activities of AST, ALT, ALP, LDH, and liver malondialdehyde level. ...... cope with MD toxicity, more attention is needed to limit its.

  3. Protein substitution to produce a processed cheese with high ...

    African Journals Online (AJOL)

    Hoida A.M. El-Shazly

    for liver enzymes; serum total and differential cholesterol profile, serum albumin, globulin and total protein along with .... Colorimetric method was used to determine AST and ALT ..... Studies on inter-organ ammonia exchange in liver cirrhosis ...

  4. Students and Instant Messaging: Survey on Current Use and Demands for Higher Education

    NARCIS (Netherlands)

    De Bakker, Gijs; Sloep, Peter; Jochems, Wim

    2008-01-01

    De Bakker, G., Sloep, P. B., & Jochems, W. M. G. (2007). Students and instant messaging: survey on current use and demands for higher education. Research in Learning Technology (ALT-J), 15(2), 143-153.

  5. Uuendamise rituaal = The ritual of renewal / Fred Thomson

    Index Scriptorium Estoniae

    Thomson, Fred

    2004-01-01

    Tartu Jaani kiriku restaureerimise käigus planeeritakse skelettide eemaldamist kiriku põranda alt - see oleks räigelt ignoreeriv restaureerimine, vaimse osa kõrvaldamine materiaalse mälestusmärgi küljest

  6. Loss of heterozygosity in colorectal cancer

    African Journals Online (AJOL)

    STORAGESEVER

    2009-12-29

    Dec 29, 2009 ... and biological features of CRC, providing us much essential information about the pathogenesis of this disease. ... In all human cancers, the molecular genetic alte- .... Kras2 gene was detected in breast, rectum, stomach,.

  7. crustal shear zone

    Indian Academy of Sciences (India)

    Textural modeling integrating the textural features and balanced chemical reaction of the calc-silicate ... The style and geometry of the .... analyses return the following amphibole forming reaction: ... based on total Al (AlT) content in hornblende.

  8. Osteogenic capacity of nanocrystalline bone cement in a weight-bearing defect at the ovine tibial metaphysis

    Directory of Open Access Journals (Sweden)

    Mittlmeier T

    2012-06-01

    Full Text Available Christoph Harms,1 Kai Helms,1 Tibor Taschner,1 Ioannis Stratos,1 Anita Ignatius,5 Thomas Gerber,2 Solvig Lenz,3 Stefan Rammelt,6 Brigitte Vollmar,4 Thomas Mittlmeier11Department of Trauma and Reconstructive Surgery, 2Department for Materials Research and Nanostructures, Institute for Physics, 3Department of Oral and Maxillofacial Plastic Surgery, 4Institute for Experimental Surgery, University of Rostock, Rostock, 5Institute of Orthopaedic Research and Biomechanics, University of Ulm, Ulm, 6Clinic of Trauma and Reconstructive Surgery, University Hospital "Carl Gustav Carus", Dresden, GermanyAbstract: The synthetic material Nanobone® (hydroxyapatite nanocrystallines embedded in a porous silica gel matrix was examined in vivo using a standardized bone defect model in the ovine tibial metaphysis. A standardized 6 × 12 × 24-mm bone defect was created below the articular surface of the medial tibia condyles on both hind legs of 18 adult sheep. The defect on the right side was filled with Nanobone®, while the defect on the contralateral side was left empty. The tibial heads of six sheep were analyzed after 6, 12, and 26 weeks each. The histological and radiological analysis of the defect on the control side did not reveal any bone formation after the total of 26 weeks. In contrast, the microcomputed tomography analysis of the defect filled with Nanobone® showed a 55%, 72%, and 74% volume fraction of structures with bone density after 6, 12, and 26 weeks, respectively. Quantitative histomorphological analysis after 6, and 12 weeks revealed an osteoneogenesis of 22%, and 36%, respectively. Hematoxylin and eosin sections demonstrated multinucleated giant cells on the surface of the biomaterial and resorption lacunae, indicating osteoclastic resorptive activity. Nanobone® appears to be a highly potent bone substitute material with osteoconductive properties in a loaded large animal defect model, supporting the potential use of Nanobone® also in

  9. Book Reviews

    Directory of Open Access Journals (Sweden)

    S. Kooijman

    1960-07-01

    Full Text Available - J.L. Swellengrebel, Jane Belo, Trance in Bali. Columbia University Press, New York 1960. XIII en 284 blz. tekst, 32 blz. foto’s. - P.E. de Josselin de Jong, J.M. Gullick, Indigenous Political Systems of Western Malaya. L.S.E. Monographs on Social Anthropology, no. 17. University of London, The Athlone Press, London 1958. 145 pp. - P.E. de Josselin de Jong, Judith Djamour, Malay kinship and marriage in Singapore. L.S.E. Monographs on Social Anthropology, No. 21. University of London, The Athlone Press, London 1959. 147 pp. - F.D.K. Bosch, A.J. Bernert Kempers, Ancient Indonesian Art. C.P.J. van der Peet, Amsterdam, 1959. 124 blz., 353 pl. - E.M. Uhlenbeck, M.E.J.G. Verstraelen, De bijwoordelijke bepalingen van het werkwoord in enkele Indonesische talen, diss. Utrecht 1955. - E.M. Uhlenbeck, A. Capell, A linguistic survey of the South-Western Pacific. South Pacific Commission Technical Paper no. 70, Noumea, New Caledonia, 1957. IX + 210 pp. with 17 maps. - E.M. Uhlenbeck, C. Maxwell Churchward, Tongan Grammar 1953, Tongan Dictionary 1959, Oxford University Press. - S. Kooijman, Tibor Bodrogi, Oceanian Art. With 160 photographs and 10 colour plates of objects in the custody of the Ethnographical Museum of Budapest. Budapest, 1959. - E.M. Uhlenbeck, H.R. Klieneberger, Bibliography of Oceanic Linguistics. London Oriental Bibliographies Vol. I, 1957. - W.F. Wertheim, Friedrich W. Funke, Dämmerung über Indonesien. Streifzüge durch Sumatra, Java, Bali und Celebes. Carl Schünemann Verlag, Bremen, 1959; 250 pp., 40 blz. foto’s. - G.H.R. von Koenigswald, W.E. le Gros Clark, The antecedents of man. Edinburgh University Publications, Science and Mathematics Texts 2, 1959, pp. 1-374, 152 textfiguren.

  10. Factors Predicting HBsAg Seroclearance and Alanine Transaminase Elevation in HBeAg-Negative Hepatitis B Virus-Infected Patients with Persistently Normal Liver Function.

    Directory of Open Access Journals (Sweden)

    Tai-Long Chien

    Full Text Available A certain proportion of hepatitis B virus (HBV-infected patients with persistently normal alanine transaminase (ALT levels have significant fibrosis. Using liver stiffness measurements (Fibroscan® and laboratory data, including serum ALT, quantitative HBsAg (qHBsAg, and HBV DNA, we attempted to predict the natural histories of these patients.Non-cirrhotic HBeAg-negative chronic hepatitis B patients with persistently normal ALT were followed up prospectively with the end points of HBsAg seroclearance and ALT elevation above the upper limit of normal. The factors that were predictive of the end points were identified.A total of 235 patients with an average age of 48.1 +/- 10.7 years were followed up for 7 years. Eight patients (3.4% lost HBsAg, and 15 patients (6.4% experienced ALT elevation. The overall cumulative HBsAg seroclearances were 0.4%, 1.3% and 2.3% at years 1, 3 and 5, respectively. Regarding HBsAg seroclearance, the qHBsAg (< 30 IU/ml cutoff resulted in a hazard ratio (HR of 19.6 with a 95% confidence interval (CI of 2.2-166.7 (P = 0.008. The baseline ALT level (odd ratio (OR 1.075, 95% CI 1.020-1.132, P = 0.006 and a qHBsAg above 1000 IU/ml (3.7, 1.1-12.4, P = 0.032 were associated with ALT elevation. Limited to men, the baseline liver stiffness (1.6, 1.0-2.5, P = 0.031 and a qHBsAg above 1000 IU/ml (10.4, 2.1-52.4, P = 0.004 were factors that were independently associated with ALT elevation.A low qHBsAg level predicted HBsAg clearance. Baseline ALT and a qHBsAg above 1000 IU/ml were independent predictive factors for ALT elevation. Among the men, the independent predictive factors for ALT elevation were qHBsAg and liver stiffness.

  11. A comparison of methods to estimate vertical land motion trends from GNSS and altimetry at tide gauge stations

    Science.gov (United States)

    Kleinherenbrink, Marcel; Riva, Riccardo; Frederikse, Thomas

    2018-03-01

    Tide gauge (TG) records are affected by vertical land motion (VLM), causing them to observe relative instead of geocentric sea level. VLM can be estimated from global navigation satellite system (GNSS) time series, but only a few TGs are equipped with a GNSS receiver. Hence, (multiple) neighboring GNSS stations can be used to estimate VLM at the TG. This study compares eight approaches to estimate VLM trends at 570 TG stations using GNSS by taking into account all GNSS trends with an uncertainty smaller than 1 mm yr-1 within 50 km. The range between the methods is comparable with the formal uncertainties of the GNSS trends. Taking the median of the surrounding GNSS trends shows the best agreement with differenced altimetry-tide gauge (ALT-TG) trends. An attempt is also made to improve VLM trends from ALT-TG time series. Only using highly correlated along-track altimetry and TG time series reduces the SD of ALT-TG time series by up to 10 %. As a result, there are spatially coherent changes in the trends, but the reduction in the root mean square (RMS) of differences between ALT-TG and GNSS trends is insignificant. However, setting correlation thresholds also acts like a filter to remove problematic TG time series. This results in sets of ALT-TG VLM trends at 344-663 TG locations, depending on the correlation threshold. Compared to other studies, we decrease the RMS of differences between GNSS and ALT-TG trends (from 1.47 to 1.22 mm yr-1), while we increase the number of locations (from 109 to 155), Depending on the methods the mean of differences between ALT-TG and GNSS trends vary between 0.1 and 0.2 mm yr-1. We reduce the mean of the differences by taking into account the effect of elastic deformation due to present-day mass redistribution. At varying ALT-TG correlation thresholds, we provide new sets of trends for 759 to 939 different TG stations. If both GNSS and ALT-TG trend estimates are available, we recommend using the GNSS trend estimates because residual

  12. Alanine Aminotransferase, ?-Glutamyltransferase, and Incident Diabetes

    OpenAIRE

    Fraser, Abigail; Harris, Ross; Sattar, Naveed; Ebrahim, Shah; Davey Smith, George; Lawlor, Debbie A.

    2009-01-01

    OBJECTIVE: To estimate and compare associations of alanine aminotransferase (ALT) and gamma-glutamyltransferase (GGT) with incident diabetes. RESEARCH DESIGN AND METHODS: ALT and GGT were studied as determinants of diabetes in the British Women's Heart and Health Study, a cohort of 4,286 women 60-79 years old (median follow-up 7.3 years). A systematic review and a meta-analysis of 21 prospective, population-based studies of ultrasonography, which diagnosed nonalcoholic fatty liver disease (NA...

  13. Liver Enzymes and Risk of Ischemic Heart Disease and Type 2 Diabetes Mellitus: A Mendelian Randomization Study

    OpenAIRE

    Liu, Junxi; Au Yeung, Shiu Lun; Lin, Shi Lin; Leung, Gabriel M.; Schooling, C. Mary

    2016-01-01

    We used Mendelian randomization to estimate the causal effects of the liver enzymes, alanine aminotransferase (ALT), alkaline phosphatase (ALP) and gamma glutamyltransferase (GGT), on diabetes and cardiovascular disease, using genetic variants predicting these liver enzymes at genome wide significance applied to extensively genotyped case-control studies of diabetes (DIAGRAM) and coronary artery disease (CAD)/myocardial infarction (MI) (CARDIoGRAMplusC4D 1000 Genomes). Genetically higher ALT ...

  14. Krise på italiensk

    DEFF Research Database (Denmark)

    Östman, Lars

    2011-01-01

    Med Berlusconis exit fra italiensk politik siger italienerne farvel til deres ridder. Men det er ikke alt, de vinker farvel til. Italienerne har endnu en gang fået deres demokrati tilsidesat. Det er de vant til.......Med Berlusconis exit fra italiensk politik siger italienerne farvel til deres ridder. Men det er ikke alt, de vinker farvel til. Italienerne har endnu en gang fået deres demokrati tilsidesat. Det er de vant til....

  15. Multiscale Assessment of Listed and At-Risk Species’ Climate Change Vulnerabilities

    Science.gov (United States)

    2017-07-15

    Assistant Secretary of the Army for Acquisition, Logistics, and Technology , ASA(ALT) Under Work Unit F94KF0, “Maneuver Area Capacity” ERDC/CERL TR-17-21...Secretary of the Army for Acquisition, Logistics, and Technology , ASA(ALT) under Program Ele- ment 622720A896, “Army Environmental Quality Technology ...relied on county-level occurrence data sourced from Nature- Serve Explorer and the USFWS Environmental Conservation Online Sys- tem ( ECOS ). Given the

  16. Alternagin-C, a disintegrin-like protein from the venom of Bothrops alternatus, modulates a2ß1 integrin-mediated cell adhesion, migration and proliferation

    Directory of Open Access Journals (Sweden)

    Selistre-de-Araujo H.S.

    2005-01-01

    Full Text Available The alpha2ß1 integrin is a major collagen receptor that plays an essential role in the adhesion of normal and tumor cells to the extracellular matrix. Alternagin-C (ALT-C, a disintegrin-like protein purified from the venom of the Brazilian snake Bothrops alternatus, competitively interacts with the alpha2ß1 integrin, thereby inhibiting collagen binding. When immobilized in plate wells, ALT-C supports the adhesion of fibroblasts as well as of human vein endothelial cells (HUVEC and does not detach cells previously bound to collagen I. ALT-C is a strong inducer of HUVEC proliferation in vitro. Gene expression analysis was done using an Affimetrix HU-95A probe array with probe sets of ~10,000 human genes. In human fibroblasts growing on collagen-coated plates, ALT-C up-regulates the expression of several growth factors including vascular endothelial growth factor, as well as some cell cycle control genes. Up-regulation of the vascular endothelial growth factor gene and other growth factors could explain the positive effect on HUVEC proliferation. ALT-C also strongly activates protein kinase B phosphorylation, a signaling event involved in endothelial cell survival and angiogenesis. In human neutrophils, ALT-C has a potent chemotactic effect modulated by the intracellular signaling cascade characteristic of integrin-activated pathways. Thus, ALT-C acts as a survival factor, promoting adhesion, migration and endothelial cell proliferation after binding to alpha2ß1 integrin on the cell surface. The biological activities of ALT-C may be helpful as a therapeutic strategy in tissue regeneration as well as in the design of new therapeutic agents targeting alpha2ß1 integrin.

  17. Introduktion af polte i PRRSV-besætninger

    DEFF Research Database (Denmark)

    Hoelstad, Bonnie Edahl; Sonne Kristensen, Charlotte; Qvist Pawlowski, Mia

    karantæne. En optimal karantæne blev defineret som en stald, der ikke delte luftrum med øvrige staldafsnit, havde separat indgang og kørte alt ind/alt ud. På trods af at poltene ikke var viræmiske ved løbning, fører studiet ikke til ændringer i anbefalingerne vedrørende introduktion af polte i PRRS...

  18. Study of nanocomposites prepared from polyamides and biodegradable polyesters and poly(ester amide)s

    OpenAIRE

    Morales Gámez, Laura Teresa

    2012-01-01

    Premi extraordinari doctorat curs 2011-2012, àmbit d’Enginyeria Industrial Polymer clay nanocomposites of polyamides and biodegradable polymers with three kinds of organomodified clays were prepared by different techniques (in situ polymerization, solution casting, and melt mixing). The polymers used in this research were nylons 56, 65 and 47 and the biodegradable polymers: poly (glycolic acid-alt-6-hydrohexanoic acid) and poly(glycolic acid-alt-6-aminohexanoic acid). The developmen...

  19. Year-to-year variability in haemoglobin mass response to two altitude training camps.

    Science.gov (United States)

    McLean, Blake D; Buttifant, David; Gore, Christopher J; White, Kevin; Kemp, Justin

    2013-12-01

    To quantify the year-to-year variability of altitude-induced changes in haemoglobin mass (Hb(mass)) in elite team-sport athletes. 12 Australian-Footballers completed a 19-day (ALT1) and 18-day (ALT2) moderate altitude (∼2100 m), training camp separated by 12 months. An additional 20 participants completed only one of the two training camps (ALT1 additional n=9, ALT2 additional n=11). Total Hb(mass) was assessed using carbon monoxide rebreathing before (PRE), after (POST₁) and 4 weeks after each camp. The typical error of Hb(mass) for the pooled data of all 32 participants was 2.6%. A contemporary statistics analysis was used with the smallest worthwhile change set to 2% for Hb(mass). POST₁ Hb(mass) was very likely increased in ALT1 (3.6 ± 1.6%, n=19; mean ± ∼90 CL) as well as ALT2 (4.4 ± 1.3%, n=23) with an individual responsiveness of 1.3% and 2.2%, respectively. There was a small correlation between ALT1 and ALT2 (R=0.21, p=0.59) for a change in Hb(mass), but a moderately inverse relationship between the change in Hb(mass) and initial relative Hb(mass) (g/kg (R=-0.51, p=0.04)). Two preseason moderate altitude camps 1 year apart yielded a similar (4%) mean increase in Hb(mass) of elite footballers, with an individual responsiveness of approximately half the group mean effect, indicating that most players gained benefit. Nevertheless, the same individuals generally did not change their Hb(mass) consistently from year to year. Thus, a 'responder' or 'non-responder' to altitude for Hb(mass) does not appear to be a fixed trait.

  20. Neuroæstetik eller kunst på hjernen

    DEFF Research Database (Denmark)

    Clasen, Mathias

    2009-01-01

    Neuroæstetikken kombinerer hjerneforskning, æstetikforskning og eksperimentel psykologi -- alt sammen for at forstå en af Homo sapiens' mest bizarre hobbyer: kunst. Forskning i kunstens neurobiologi griber om sig.......Neuroæstetikken kombinerer hjerneforskning, æstetikforskning og eksperimentel psykologi -- alt sammen for at forstå en af Homo sapiens' mest bizarre hobbyer: kunst. Forskning i kunstens neurobiologi griber om sig....

  1. Anmeldelse: Funktionel sproglig analyse - en metode til læsning i fagene

    DEFF Research Database (Denmark)

    Mulvad, Ruth

    2011-01-01

    Bogen handler om arbejdet med sprog og læsning i skolens fag. I USA er der nemlig - som så mange andre steder verden over - alt for mange elever, som ikke kan læse de komplicerede tekster, som de møder i skolen. Der er også alt for mange lærere, der ikke ved, hvad de skal gribe og gøre i....

  2. Extrapolating active layer thickness measurements across Arctic polygonal terrain using LiDAR and NDVI data sets.

    Science.gov (United States)

    Gangodagamage, Chandana; Rowland, Joel C; Hubbard, Susan S; Brumby, Steven P; Liljedahl, Anna K; Wainwright, Haruko; Wilson, Cathy J; Altmann, Garrett L; Dafflon, Baptiste; Peterson, John; Ulrich, Craig; Tweedie, Craig E; Wullschleger, Stan D

    2014-08-01

    Landscape attributes that vary with microtopography, such as active layer thickness ( ALT ), are labor intensive and difficult to document effectively through in situ methods at kilometer spatial extents, thus rendering remotely sensed methods desirable. Spatially explicit estimates of ALT can provide critically needed data for parameterization, initialization, and evaluation of Arctic terrestrial models. In this work, we demonstrate a new approach using high-resolution remotely sensed data for estimating centimeter-scale ALT in a 5 km 2 area of ice-wedge polygon terrain in Barrow, Alaska. We use a simple regression-based, machine learning data-fusion algorithm that uses topographic and spectral metrics derived from multisensor data (LiDAR and WorldView-2) to estimate ALT (2 m spatial resolution) across the study area. Comparison of the ALT estimates with ground-based measurements, indicates the accuracy (r 2  = 0.76, RMSE ±4.4 cm) of the approach. While it is generally accepted that broad climatic variability associated with increasing air temperature will govern the regional averages of ALT , consistent with prior studies, our findings using high-resolution LiDAR and WorldView-2 data, show that smaller-scale variability in ALT is controlled by local eco-hydro-geomorphic factors. This work demonstrates a path forward for mapping ALT at high spatial resolution and across sufficiently large regions for improved understanding and predictions of coupled dynamics among permafrost, hydrology, and land-surface processes from readily available remote sensing data.

  3. Platons ‘respekt’ for Protagoras

    DEFF Research Database (Denmark)

    Bloch, David

    2011-01-01

    Platons forhold til sofisten Protagoras behandles. Hvor forskningen oftest har hævdet, at Platon har stor respekt for denne, argumenteres der her for, at Platons dialog "Protagoras" viser alt andet end respekt.......Platons forhold til sofisten Protagoras behandles. Hvor forskningen oftest har hævdet, at Platon har stor respekt for denne, argumenteres der her for, at Platons dialog "Protagoras" viser alt andet end respekt....

  4. Tool for calculation of the life cycle cost for different heating systems in one-family houses; Verktyg foer beraekning av livscykelkostnaden foer olika vaermesystem i smaahus

    Energy Technology Data Exchange (ETDEWEB)

    Larsson, Jenny; Strand, Hanna [Lund Inst. of Technology (Sweden). Dept. of Chemical Engineering

    2003-12-01

    The Excel-based tool can be used by the consumer and covers the following heating systems: direct electric heating (alt. in combination with an air source heat pump), electric boiler (alt. in combination with an air source heat pump), fuel oil boiler, wood pellets boiler, natural gas boiler, exhaust air heat pump, ground source heat pump (surface soil or boreholes) and district heating. A few case studies are reviewed in order to illustrates the use of the tool.

  5. Modelling of Leaching of Pesticides - PESTLA and MACRO

    DEFF Research Database (Denmark)

    Rasmussen, D.

    Miljøprojekt, 310; I tilknytning til hovedrapporten Environmental Exposure Assessment of Chemicals (Miljøprojekt, 306) er udgivet i alt 5 tekniske bilagsrapporter, alle i serien Miljøprojekt.......Miljøprojekt, 310; I tilknytning til hovedrapporten Environmental Exposure Assessment of Chemicals (Miljøprojekt, 306) er udgivet i alt 5 tekniske bilagsrapporter, alle i serien Miljøprojekt....

  6. Gender difference of alanine aminotransferase elevation may be associated with higher hemoglobin levels among male adolescents.

    Directory of Open Access Journals (Sweden)

    Solomon Chih-Cheng Chen

    Full Text Available BACKGROUND: To explore the gender difference of ALT elevation and its association with high hemoglobin levels. METHODS: A cross-sectional study of 3547 adolescents (2005 females, mean age of 16.5?.3 years who were negative for hepatitis B surface antigen received health checkups in 2006. Body mass index (BMI, levels of hemoglobin, ALT and cholesterol were measured. ALT >42 U/L was defined as elevated ALT. Elevated ALT levels were detected in 112 of the 3547 participants (3.3%, more prevalent in males than in females (5.4% vs. 1.4%, p11 g/dl in females or >13.5 g/dl in males, but the cumulative cases of elevated ALT increased more quickly in males. Proportion of elevated ALT increased as either the BMI or hemoglobin level rise, more apparent in male adolescents. Logistic regression modeling showed odds ratio (95% confidence interval were 24.7 (15.0-40.6 for BMI ≥27 kg/m(2; 5.5 (2.9-10.4 for BMI 24-27 kg/m(2; 2.7 (1.3-5.5 for Q5 (top 20th percentile hemoglobin level; and 2.6 (1.6-4.1 for male gender. Further separately fitting the logistic models for two genders, the significance of Q5 hemoglobin level only appeared in the males. CONCLUSIONS: High hemoglobin level is a significant risk factor of ALT elevation after control hepatitis B, obesity and gender. Males have greater risk of abnormal liver function which may be associated with higher hemoglobin levels.

  7. Vitamin D status, liver enzymes, and incident liver disease and mortality

    DEFF Research Database (Denmark)

    Skaaby, Tea; Husemoen, Lise Lotte Nystrup; Borglykke, Anders

    2014-01-01

    , alcohol consumption, smoking, physical activity, dietary habits, education, body mass index, and ALT). The risk of having a high level of ALT, AST, or GGT tended to be higher for lower vitamin D levels, although not statistically significant. In this general population study, vitamin D status...... was inversely associated with incident liver disease. Further studies are needed to determine whether patients in risk of developing impaired liver function should be screened for vitamin D deficiency for preventive purposes....

  8. Den radikale Kings skandinaviske drøm

    DEFF Research Database (Denmark)

    Brøndal, Jørn

    2013-01-01

    I dag forgudes Martin Luther King for sin racemæssige vision. Derimod aner de fleste amerikanere ikke noget om hans økonomiske ideer, og hvis de gjorde, ville mange af dem utvivlsomt affeje dem som alt for radikale......I dag forgudes Martin Luther King for sin racemæssige vision. Derimod aner de fleste amerikanere ikke noget om hans økonomiske ideer, og hvis de gjorde, ville mange af dem utvivlsomt affeje dem som alt for radikale...

  9. High-efficiency pyrene-based blue light emitting diodes: Aggregation suppression using a calixarene 3D-scaffold

    KAUST Repository

    Chan, Khaileok

    2012-01-01

    An efficient blue light emitting diode based on solution processable pyrene-1,3-alt-calix[4]arene is demonstrated, providing a record current efficiency of 10.5 cd A -1 in a simple non-doped OLED configuration. Complete suppression of pyrene aggregation in the solid state is achieved by controlling chromophore dispersion using the 1,3-alt-calix[4]arene scaffold. © 2012 The Royal Society of Chemistry.

  10. Clinical relevance and discriminatory value of elevated liver aminotransferase levels for dengue severity.

    Science.gov (United States)

    Lee, Linda K; Gan, Victor C; Lee, Vernon J; Tan, Adriana S; Leo, Yee Sin; Lye, David C

    2012-01-01

    Elevation of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) is prominent in acute dengue illness. The World Health Organization (WHO) 2009 dengue guidelines defined AST or ALT ≥ 1000 units/liter (U/L) as a criterion for severe dengue. We aimed to assess the clinical relevance and discriminatory value of AST or ALT for dengue hemorrhagic fever (DHF) and severe dengue. We retrospectively studied and classified polymerase chain reaction positive dengue patients from 2006 to 2008 treated at Tan Tock Seng Hospital, Singapore according to WHO 1997 and 2009 criteria for dengue severity. Of 690 dengue patients, 31% had DHF and 24% severe dengue. Elevated AST and ALT occurred in 86% and 46%, respectively. Seven had AST or ALT ≥ 1000 U/L. None had acute liver failure but one patient died. Median AST and ALT values were significantly higher with increasing dengue severity by both WHO 1997 and 2009 criteria. However, they were poorly discriminatory between non-severe and severe dengue (e.g., AST area under the receiver operating characteristic [ROC] curve=0.62; 95% confidence interval [CI]: 0.57-0.67) and between dengue fever (DF) and DHF (AST area under the ROC curve=0.56; 95% CI: 0.52-0.61). There was significant overlap in AST and ALT values among patients with dengue with or without warning signs and severe dengue, and between those with DF and DHF. Although aminotransferase levels increased in conjunction with dengue severity, AST or ALT values did not discriminate between DF and DHF or non-severe and severe dengue.

  11. Facebook

    DEFF Research Database (Denmark)

    Konzack, Lars

    2013-01-01

    Alt i alt er det en vellykket bog om Facebook. Det hjælper, at man har valgt et så klart emneområde, så artiklerne ikke stikker ud i alle retninger. Men det har måske den uheldige virkning, at mange artikler kommer til at gentage de samme pointer om funktionaliteten i Facebook. Det kan man dog godt...

  12. Approach and Landing Test emblem

    Science.gov (United States)

    1976-01-01

    This circular, red, white, and blue emblem has been chosen as the Official insignia for the Space Shuttle Approach and Landing Test (ALT) flights. A picture of the Orbiter 101 'Enterprise' is superimposed over a red triangle, which in turn is superimposed over a large inner circle of dark blue. The surnames of the members of the two ALT crews are in white in the field of blue.

  13. Book Reviews

    Directory of Open Access Journals (Sweden)

    Jerome Rousseau

    1984-04-01

    Full Text Available - Henri J.M. Claessen, Ross H. Cordy, A study of prehistoric social change: The development of complex societies in the Hawaiian Islands, New York: Academic Press, 1981, 274 pp., Maps, ills., index, Appendices. - Th. van den End, C. Guillot, L’affaire Sadrach. Un essai de christianisation à Java au XIXe siècle. Editions de la Maison des Sciences de l’Homme, Paris 1981.374 pp. Etudes insulindiennes/Archipel 4. - Renée Hagesteijn, A. Milner, Kerajaan: Malay political culture on the eve of colonial rule. The Association for Asian Studies, Monograph no. XL, University of Arizona Press, Tucson, 1982. - P. van Hees, Emile Henssen, Gerretson en Indië. Bouma’s Boekhuis/Wolters Noordhoff, Groningen 1983. 231 blz. + los register. - M. Hekker, H.D. Kubitschek, Geschichte Indonesiens. Vom Altertum bis zur Gegenwart, Akademie Verlag, Berlin, 1981. xiii + 266 pp., I. Wessel (eds. - Huynh Kim Khánh, W.R. Smyses, The independent Vietnamese: Vietnamese communism between Russia and China, Athens, Ohio: Ohio University Center for International Studies, Southeast Asia Program, 1980, 143 pages, bibliography. - Saskia Keller, Sandra Hira, Van Priary tot en met De Kom. De geschiedenis van het verzet in Suriname, 1630-1940, Rotterdam: Uitgeverij Futile, 1982. - Gerrit J. Knaap, R.Z. Leirissa, Maluku Tengah di masa lampau. Gambaran sekilas lewat arsip abad sembilan belas, Penerbitan Sumber-Sumber Sejarah no. 13, Arsip Nasional Republik Indonesia, Jakarta 1982. XIV + 218 pp., Z.J. Manusama, A.B. Lapian (eds. - S. Kooijman, Tibor Bodrogi, Stammeskunst, Vol I, Australien, Ozeanien, Afrika, ed. by Tibor Bodrogi, 306 pp., 396 photographs (16 coloured, 13 sketch maps. Vol. II. Amerika, Asien, ed. by Tibor Bodrogi and Lajos Boglár, 274 pp., 238 photographs (16 coloured, 8 sketch maps. German translation of Tözsi Müvészet, Budapest, Corvina Kiadó, 1982., Lajos Boglár (eds. - H.M.J. Maier, R.G. Tol, Raja Ali Haji Ibn Ahmad, The Precious Gift (Tuhfat al-Nafis. An

  14. Prevalence of metabolic syndrome and risks of abnormal serum alanine aminotransferase in Hispanics: a population-based study.

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    Jen-Jung Pan

    Full Text Available Study the prevalence of metabolic syndrome (MS and risk factors for and association with elevated alanine aminotransferase (ALT as markers of hepatic injury in a large Hispanic health disparity cohort with high rates of obesity.Analysis of data from a prospective cross-sectional population based study. From 2004-7, we randomly recruited 2000 community participants to the Cameron County Hispanic Cohort collecting extensive socioeconomic, clinical and laboratory data. We excluded 153 subjects due to critical missing data. Pearson chi-square tests and Student's t-tests were used for categorical and continuous variable analysis, respectively. Logistic regression analysis was performed to determine the risk factors for elevated ALT.The mean age of the cohort was 45 years and 67% were females. The majority of the cohort was either overweight (32.4% or obese (50.7%. Almost half (43.7% had MS and nearly one-third diabetes. Elevated ALT level was more prevalent in males than females. Obesity was a strong risk for abnormal ALT in both genders. Hypertriglyceridemia, hypercholesterolemia and young age were risks for elevated ALT in males only, whereas increased fasting plasma glucose was associated with elevated ALT in females only.We identified high prevalence of MS and markers of liver injury in this large Mexican American cohort with gender differences in prevalence and risk factors, with younger males at greatest risk.

  15. Coffee consumption is associated with lower serum aminotransferases in the general Korean population and in those at high risk for hepatic disease.

    Science.gov (United States)

    Oh, Myueng Guen; Han, Mi Ah; Kim, Man Woo; Park, Chan Guk; Kim, Young Dae; Lee, Jun

    2016-12-01

    The favourable effects of coffee on liver enzymes have been reported worldwide. This study investigated the association between coffee consumption and serum aminotransferase concentration in Korean adults. Data were obtained from the fourth and fifth Korea National Health and Nutrition Examination Surveys. Elevated alanine aminotransferase (ALT) and aspartate aminotransferase (AST) concentration were defined as >30 IU/L for men and >19 IU/L for women. The risk of elevated ALT and AST according to general characteristics and frequency of coffee consumption were tested by chi-square tests and multiple logistic regression analyses. The prevalence of elevated ALT was 27.4%, 27.8%, and 26.9% in subjects who drank =2 times/day, respectively. The proportions of individuals with elevated AST were 32.5%, 33.1%, and 26.7% in subjects who drank =2 times/day, respectively. The aORs for elevated ALT and AST were significantly lower in subjects who drank >=2 times of coffee/day than in those who drank =2 times/day was associated with lower ORs for elevated ALT in the high-risk group overall and in the viral hepatitis and obesity subgroups, respectively. In sensitivity analysis, reduced frequency of coffee consumption was associated with an increased risk for elevated liver enzymes, although an association between coffee consumption and elevated ALT was not observed in women or current smokers. Higher coffee consumption was associated with lower risk of elevated aminotransferase concentration in Korean adults.

  16. PGC-1α regulates alanine metabolism in muscle cells.

    Science.gov (United States)

    Hatazawa, Yukino; Qian, Kun; Gong, Da-Wei; Kamei, Yasutomi

    2018-01-01

    The skeletal muscle is the largest organ in the human body, depositing energy as protein/amino acids, which are degraded in catabolic conditions such as fasting. Alanine is synthesized and secreted from the skeletal muscle that is used as substrates of gluconeogenesis in the liver. During fasting, the expression of PGC-1α, a transcriptional coactivator of nuclear receptors, is increased in the liver and regulates gluconeogenesis. In the present study, we observed increased mRNA expression of PGC-1α and alanine aminotransferase 2 (ALT2) in the skeletal muscle during fasting. In C2C12 myoblast cells overexpressing PGC-1α, ALT2 expression was increased concomitant with an increased alanine level in the cells and medium. In addition, PGC-1α, along with nuclear receptor ERR, dose-dependently enhanced the ALT2 promoter activity in reporter assay using C2C12 cells. In the absence of glucose in the culture medium, mRNA levels of PGC-1α and ALT2 increased. Endogenous PGC-1α knockdown in C2C12 cells reduced ALT2 gene expression level, induced by the no-glucose medium. Taken together, in the skeletal muscle, PGC-1α activates ALT2 gene expression, and alanine production may play roles in adaptation to fasting.

  17. Hyperferritinemia and hyperuricemia may be associated with liver function abnormality in obese adolescents.

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    Solomon Chih Cheng Chen

    Full Text Available The iron status in human body and its association with liver function in adolescents was rarely studied. The objective was to investigate the association among the levels of serum ferritin, uric acid and alanine aminotransferase (ALT in adolescents.A total of 2090 adolescents negative for hepatitis B surface antigen from one junior high school (786, 12-13 years, three senior high schools (973, 15-16 years and one college (331, 18-19 years participated in this survey. Anthropometric and biochemical measurements, including complete blood count, ALT, serum ferritin and uric acid were performed. An ALT>42 U/L was defined as elevated, a ferritin level >200 µg/L was defined as hyperferritinemia. A uric acid level >460 µmol/L in males and >340 µmol/L in females was defined as hyperuricemia. The chi-squared test, linear regression and multivariate logistic regression were used for the data analysis. Elevated ALT levels were detected in 76 (3.6% students and were more prevalent in males than females (6.4% vs. 2.0%, p100 µg/L. The logistic regression analysis found that body mass index, hyperferritinemia and hyperuricemia were significant factors associated with the ALT elevation, but gender, age, and white blood cell count were not.Hyperferritinemia and hyperuricemia are two independently significant factors associated with ALT elevation among obese adolescents. More studies are needed to corroborate any hypothesis related to these phenomena.

  18. Characterization of photosynthetic gas exchange in leaves under simulated adaxial and abaxial surfaces alternant irradiation.

    Science.gov (United States)

    Zhang, Zi-Shan; Li, Yu-Ting; Gao, Hui-Yuan; Yang, Cheng; Meng, Qing-Wei

    2016-07-05

    Previous investigations on photosynthesis have been performed on leaves irradiated from the adaxial surface. However, leaves usually sway because of wind. This action results in the alternating exposure of both the adaxial and abaxial surfaces to bright sunlight. To simulate adaxial and abaxial surfaces alternant irradiation (ad-ab-alt irradiation), the adaxial or abaxial surface of leaves were exposed to light regimes that fluctuated between 100 and 1,000 μmol m(-2) s(-1). Compared with constant adaxial irradiation, simulated ad-ab-alt irradiation suppressed net photosynthetic rate (Pn) and transpiration (E) but not water use efficiency. These suppressions were aggravated by an increase in alternant frequency of the light intensity. When leaves were transferred from constant light to simulated ad-ab-alt irradiation, the maximum Pn and E during the high light period decreased, but the rate of photosynthetic induction during this period remained constant. The sensitivity of photosynthetic gas exchange to simulated ad-ab-alt irradiation was lower on abaxial surface than adaxial surface. Under simulated ad-ab-alt irradiation, higher Pn and E were measured on abaxial surface compared with adaxial surface. Therefore, bifacial leaves can fix more carbon than leaves with two "sun-leaf-like" surfaces under ad-ab-alt irradiation. Photosynthetic research should be conducted under dynamic conditions that better mimic nature.

  19. Clinical implications in the prevalence and associated cardiovascular factors of elevated serum alanine aminotransferase levels among elderly agricultural and fishing population in Taipei, Taiwan: experience at a teaching hospital.

    Science.gov (United States)

    Chen, Yu-Fen; Hu, Yi-Chun; Shen, Hsi-Che; Chang, Hui-Te; Tung, Tao-Hsin

    2014-01-01

    To discuss the prevalence and associated factors related to an elevated serum alanine aminotransferase (ALT) level among the elderly agricultural and fishing population. A total of 6542 (3989 males and 2553 females) healthy adults voluntarily admitted to a teaching hospital for a physical checkup in 2010 in Taipei, Taiwan. Fasting blood samples were drawn via venipuncture, and clinical nurses interviewed the study participants using a structured questionnaire from. The overall prevalence of an elevated serum ALT level was 18.2% and revealed a statistically significant decrease with increasing age (P < 0.001). The men exhibited a higher prevalence than the women (19.7% vs 15.9%; P < 0.001). Male sex; younger age; and presence of obesity, hypertension, hyperuricemia, and hypoalbuminemia were significantly associated with an elevated serum ALT level. Sex-related differences were also revealed. For the men, type 2 diabetes (odds ratio [OR], 1.23; 95% confidence interval [CI], 1.02-1.57), hypercholesterolemia (OR, 1.78; 95% CI, 1.22-2.83), hypertriglyceridemia (OR, 1.32; 95% CI, 1.04-1.73), and low high-density lipoprotein (OR, 1.26; 95% CI, 1.05-1.51) were significantly related to an elevated serum ALT level, but this was not so for the women. The disparity of ALT in age groups was revealed. Several sex-related differences were indicated pertaining to the prevalence of an elevated serum ALT level among elderly specific occupational population.

  20. Combined Mass Spectrometry Imaging and Top-down Microproteomics Reveals Evidence of a Hidden Proteome in Ovarian Cancer.

    Science.gov (United States)

    Delcourt, Vivian; Franck, Julien; Leblanc, Eric; Narducci, Fabrice; Robin, Yves-Marie; Gimeno, Jean-Pascal; Quanico, Jusal; Wisztorski, Maxence; Kobeissy, Firas; Jacques, Jean-François; Roucou, Xavier; Salzet, Michel; Fournier, Isabelle

    2017-07-01

    Recently, it was demonstrated that proteins can be translated from alternative open reading frames (altORFs), increasing the size of the actual proteome. Top-down mass spectrometry-based proteomics allows the identification of intact proteins containing post-translational modifications (PTMs) as well as truncated forms translated from reference ORFs or altORFs. Top-down tissue microproteomics was applied on benign, tumor and necrotic-fibrotic regions of serous ovarian cancer biopsies, identifying proteins exhibiting region-specific cellular localization and PTMs. The regions of interest (ROIs) were determined by MALDI mass spectrometry imaging and spatial segmentation. Analysis with a customized protein sequence database containing reference and alternative proteins (altprots) identified 15 altprots, including alternative G protein nucleolar 1 (AltGNL1) found in the tumor, and translated from an altORF nested within the GNL1 canonical coding sequence. Co-expression of GNL1 and altGNL1 was validated by transfection in HEK293 and HeLa cells with an expression plasmid containing a GNL1-FLAG (V5) construct. Western blot and immunofluorescence experiments confirmed constitutive co-expression of altGNL1-V5 with GNL1-FLAG. Taken together, our approach provides means to evaluate protein changes in the case of serous ovarian cancer, allowing the detection of potential markers that have never been considered. Copyright © 2017 The Author(s). Published by Elsevier B.V. All rights reserved.

  1. Insulin-like growth factor 1, liver enzymes, and insulin resistance in patients with PCOS and hirsutism.

    Science.gov (United States)

    Çakir, Evrim; Topaloğlu, Oya; Çolak Bozkurt, Nujen; Karbek Bayraktar, Başak; Güngüneş, Aşkın; Sayki Arslan, Müyesser; Öztürk Ünsal, İlknur; Tutal, Esra; Uçan, Bekir; Delıbaşi, Tuncay

    2014-01-01

    Hyperinsulinemia and insulin resistance are commonly seen in patients with hirsutism and polycystic ovary syndrome (PCOS), and are associated with cardiovascular disease risk. However, it is not yet known whether insulin-like growth factor I (IGF-I) and alanine transaminase (ALT) produced by the liver play roles in hyperinsulinemia and subclinical atherosclerotic process in patients with PCOS and idiopathic hirsutism (IH). This was a prospective case-controlled study. The study population consisted of 25 reproductive-age PCOS women, 33 women with IH, and 25 control subjects. Mean IGF-I levels and median ALT levels were higher in patients with IH and PCOS than controls, but these differences were not statistically significant. The participants who had a homeostasis model assessment insulin resistance index (HOMA-IR) greater than 2.7 had significantly higher IGF-1 and ALT levels. ALT levels were positively correlated with body mass index, FG, insulin and HOMA-IR. The study illustrated that IGF-1 and ALT levels were significantly higher in patients with increased insulin resistance. Due to short disease duration in younger participants, we did not observe any correlation between IGF-1 and hyperinsulinemia. These findings suggest that increased hepatic production of IGF-I and ALT might be an early indicator of insulin resistance in hirsutism.

  2. w∞ algebras, conformal mechanics and black holes

    Science.gov (United States)

    Cacciatori, Sergio; Klemm, Dietmar; Zanon, Daniela

    2000-04-01

    We discuss BPS solitons in gauged icons/Journals/Common/calN" ALT="calN" ALIGN="TOP"/> = 2, D = 4 supergravity. The solitons represent extremal black holes interpolating between different vacua of anti-de Sitter spaces. The isometry superalgebras are determined and the motion of a superparticle in the extremal black hole background is studied and confronted with superconformal mechanics. We show that the Virasoro symmetry of conformal mechanics, which describes the dynamics of the superparticle near the horizon of the extremal black hole under consideration, extends to a symmetry under the wicons/Journals/Common/infty" ALT="infty" ALIGN="MIDDLE"/> algebra of area-preserving diffeomorphisms. We find that a Virasoro subalgebra of wicons/Journals/Common/infty" ALT="infty" ALIGN="MIDDLE"/> can be associated with the Virasoro algebra of the asymptotic symmetries of AdS 2 . In this way spacetime diffeomorphisms of AdS 2 translate into diffeomorphisms in phase space: our system offers an explicit realization of the AdS 2 /CFT 1 correspondence. Using the dimensionally reduced action, the central charge is computed. Finally, we also present generalizations of superconformal mechanics which are invariant under icons/Journals/Common/calN" ALT="calN" ALIGN="TOP"/> = 1 and icons/Journals/Common/calN" ALT="calN" ALIGN="TOP"/> = 2 superextensions of wicons/Journals/Common/infty" ALT="infty" ALIGN="MIDDLE"/> .

  3. A Population of Projection Neurons that Inhibits the Lateral Horn but Excites the Antennal Lobe through Chemical Synapses in Drosophila

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    Kazumichi Shimizu

    2017-05-01

    Full Text Available In the insect olfactory system, odor information is transferred from the antennal lobe (AL to higher brain areas by projection neurons (PNs in multiple AL tracts (ALTs. In several species, one of the ALTs, the mediolateral ALT (mlALT, contains some GABAergic PNs; in the Drosophila brain, the great majority of ventral PNs (vPNs are GABAergic and project through this tract to the lateral horn (LH. Most excitatory PNs (ePNs, project through the medial ALT (mALT to the mushroom body (MB and the LH. Recent studies have shown that GABAergic vPNs play inhibitory roles at their axon terminals in the LH. However, little is known about the properties and functions of vPNs at their dendritic branches in the AL. Here, we used optogenetic and patch clamp techniques to investigate the functional roles of vPNs in the AL. Surprisingly, our results show that specific activation of vPNs reliably elicits strong excitatory postsynaptic potentials (EPSPs in ePNs. Moreover, the connections between vPNs and ePNs are mediated by direct chemical synapses. Neither pulses of GABA, nor pharmagological, or genetic blockade of GABAergic transmission gave results consistent with the involvement of GABA in vPN-ePN excitatory transmission. These unexpected results suggest new roles for the vPN population in olfactory information processing.

  4. Diagnosis of hepatitis C virus in Brazilian blood donors using a reverse transcriptase nested polymerase chain reaction: comparison with enzyme immunoassay and recombinant protein immunoblot assay Diagnóstico da hepatite por vírus C em doadores de sangue brasileiros, usando a reação de transcrição reversa e a reação em cadeia da polimerase "nested": comparação com os ensaios imunoenzimáticos e imunoblot recombinante

    Directory of Open Access Journals (Sweden)

    Neiva S. L. GONÇALES

    2000-10-01

    Full Text Available Screening blood donations for anti-HCV antibodies and alanine aminotransferase (ALT serum levels generally prevents the transmission of hepatitis C virus (HCV by transfusion. The aim of the present study was to evaluate the efficiency of the enzyme immunoassay (EIA screening policy in identifying potentially infectious blood donors capable to transmit hepatitis C through blood transfusion. We have used a reverse transcriptase (RT-nested polymerase chain reaction (PCR to investigate the presence of HCV-RNA in blood donors. The prevalence of HCV-RNA positive individuals was compared with the recombinant immunoblot assay (RIBA-2 results in order to assess the usefulness of both tests as confirmatory assays. Both tests results were also compared with the EIA-2 OD/C ratio (optical densities of the samples divided by the cut off value. ALT results were expressed as the ALT quotient (qALT, calculated dividing the ALT value of the samples by the maximum normal value (53UI/l for the method. Donors (n=178 were divided into five groups according to their EIA anti-HCV status and qALT: group A (EIA > or = 3, ALT or = 3, ALT>1, group C (11 and group E (EIA or = 3 and detectable HCV-RNA by RT-nested PCR. We have also noted that blood donors with RIBA-2 indeterminate presented a high degree of detectable HCV-RNA using RT-nested PCR (75%, especially when the c22.3 band was detected.Na prevenção da transmissão de Hepatite por Vírus C (HCV em transfusões de hemocomponentes, utiliza-se rotineiramente, como testes de triagem de doadores de sangue, ensaios que detectam anticorpos anti-HCV e dosagens da enzima alanina-aminotransferase (ALT. O presente estudo tem como objetivo principal avaliar a eficiência do ensaio imunoenzimático de segunda geração (EIA-2 como teste de triagem, na identificação de doadores de sangue potencialmente infectados, e portanto, capazes de transmitir hepatite C pelos hemocomponentes. Nós utilizamos o ensaio de transcri

  5. Elevated alanine aminotransferase is strongly associated with incident metabolic syndrome: a meta-analysis of prospective studies.

    Directory of Open Access Journals (Sweden)

    Zhengtao Liu

    Full Text Available BACKGROUND: The incidence of metabolic syndrome (MetS is rapidly increasing worldwide and associated with alanine aminotransferase (ALT activity. However, the impact of ALT activity on MetS incidence is inconsistent in published literature. We therefore estimated the association between elevated ALT activity and incident MetS through a meta-analysis of prospective cohort studies. METHODS/PRINCIPAL FINDINGS: All published prospective cohort studies on the association between elevated ALT activity and incident MetS were retrieved from Pubmed, Embase, and the Institute for Scientific Information (ISI. In all, seven prospective cohort studies, with 31545 participants and 2873 cases of incident MetS were recruited. If there was insignificant heterogeneity (P-value>0.05 and I(2<50%, the fixed-effect model was used to calculate the pooled relative risks (RRs of incident MetS induced by raised ALT. Otherwise, the random-effect model was used. The calculated RR was 1.81 (95% confidence interval [CI]: 1.49-2.14 when the incidence of MetS was compared between the highest versus the lowest classification of ALT activities. The pooled RR was 1.13 (95% CI: 1.11-1.16 in dose-response analysis with 5 units per liter (U/l of ALT increment. Subgroup analysis suggested that gender disparity might be the main origin of heterogeneity in overall analysis (P = 0.007 between RRs of gender-specific subgroups evaluated with 5 U/l increments of ALT. Women had a higher dose-response risk of MetS incidence (1.38, 95% CI: 1.20-1.55 than men. Furthermore, sensitivity analysis confirmed the stability of results. No publication bias was found in our meta-analysis. CONCLUSIONS/SIGNIFICANCE: Current evidence from prospective studies supports the association between ALT elevation and increasing MetS incidence. This association is closer and more consistent in female population. Further studies are needed to confirm this association and to investigate the potential mechanism of

  6. Doença hepática gordurosa não alcoólica em escolares obesos Nonalcoholic fatty liver disease in obese children

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    Fabíola Isabel S. Souza

    2008-06-01

    Full Text Available OBJETIVO: Avaliar a prevalência de alterações hepáticas ao ultra-som e de elevação da alanina aminotransferase (ALT em crianças com sobrepeso e obesidade, além de relacionar a presença de alterações com peroxidação lipídica, perfil lipídico e resistência insulínica. MÉTODOS: Estudo transversal, prospectivo e controlado de 67 crianças com sobrepeso/obesidade (38 do sexo feminino e média de idade de 8,6 anos, pareadas por sexo e idade com 65 eutróficas. A avaliação bioquímica consistiu de perfil lipídico (LDL-c, HDL-c e triglicerídeos; ALT; substâncias reativas ao ácido tiobarbitúrico (TBARS; glicemia e insulina, utilizadas para o cálculo do Homeostasis Model Assessment Insulin Resistance (HOMA-IR. A esteatose hepática, avaliada por ultra-sonografia por um único examinador, foi classificada em difusa leve, moderada e grave. RESULTADOS: Elevação de ALT (>40U/L foi encontrada em 3% e alterações ultra-sonográficas do fígado em 57,4% das crianças com sobrepeso e obesidade. O Grupo Sobrepeso/Obesidade apresentou maior percentual de ALT >18U/L (OR 4,2; p=0,0006 e de hipertrigliceridemia (OR 4,2; p18U/L. CONCLUSÕES: A freqüência de ALT >40U/L foi baixa e a de esteatose foi alta. As alterações ultra-sonográficas hepáticas não mostraram associação com o estado nutricional nem com os níveis de ALT. Por sua vez, triglicerídeos aumentados associaram-se com níveis mais elevados de ALT.OBJECTIVE: To evaluate the prevalence of altered hepatic ultrasound and elevated serum alanine aminotransferase (ALT in overweight and obese children, as well as to relate them to lipid peroxidation, lipid profile and insulin resistance. METHODS: A prospective, controlled, cross-sectional study was performed with 67 overweight and obese children (38 female, mean age of 8,6 years paired by gender and age with 65 eutrophic controls. The following parameters were evaluated: lipid profile (LDL-c, HDL-c, triglycerides, ALT, lipid

  7. Characterizing permafrost active layer dynamics and sensitivity to landscape spatial heterogeneity in Alaska

    Science.gov (United States)

    Yi, Yonghong; Kimball, John S.; Chen, Richard H.; Moghaddam, Mahta; Reichle, Rolf H.; Mishra, Umakant; Zona, Donatella; Oechel, Walter C.

    2018-01-01

    An important feature of the Arctic is large spatial heterogeneity in active layer conditions, which is generally poorly represented by global models and can lead to large uncertainties in predicting regional ecosystem responses and climate feedbacks. In this study, we developed a spatially integrated modeling and analysis framework combining field observations, local-scale ( ˜ 50 m resolution) active layer thickness (ALT) and soil moisture maps derived from low-frequency (L + P-band) airborne radar measurements, and global satellite environmental observations to investigate the ALT sensitivity to recent climate trends and landscape heterogeneity in Alaska. Modeled ALT results show good correspondence with in situ measurements in higher-permafrost-probability (PP ≥ 70 %) areas (n = 33; R = 0.60; mean bias = 1.58 cm; RMSE = 20.32 cm), but with larger uncertainty in sporadic and discontinuous permafrost areas. The model results also reveal widespread ALT deepening since 2001, with smaller ALT increases in northern Alaska (mean trend = 0.32±1.18 cm yr-1) and much larger increases (> 3 cm yr-1) across interior and southern Alaska. The positive ALT trend coincides with regional warming and a longer snow-free season (R = 0.60 ± 0.32). A spatially integrated analysis of the radar retrievals and model sensitivity simulations demonstrated that uncertainty in the spatial and vertical distribution of soil organic carbon (SOC) was the largest factor affecting modeled ALT accuracy, while soil moisture played a secondary role. Potential improvements in characterizing SOC heterogeneity, including better spatial sampling of soil conditions and advances in remote sensing of SOC and soil moisture, will enable more accurate predictions of active layer conditions and refinement of the modeling framework across a larger domain.

  8. Complex association of serum alanine aminotransferase with the risk of future cardiovascular disease in type 2 diabetes.

    Science.gov (United States)

    Afarideh, Mohsen; Aryan, Zahra; Ghajar, Alireza; Noshad, Sina; Nakhjavani, Manouchehr; Baber, Usman; Mechanick, Jeffrey I; Esteghamati, Alireza

    2016-11-01

    We aimed to determine the prospective association between baseline serum levels of alanine aminotransferase (ALT) and the incident cardiovascular disease (CVD) in people with type 2 diabetes. In an open cohort setting, people with type 2 diabetes were followed for their first ever CVD presentation from 1995 to 2015. Statistical methods included Cox regression analysis for reporting of hazard ratios (HRs), artificial neural network modelings, and risk reclassification analyses. We found a nearly constant CVD hazard with baseline serum ALT levels below the 30 IU/L mark, whereas baseline serum ALT levels ≥ 30 IU/L remained an independent predictor of lower CVD rates in patients with type 2 diabetes in the final multivariate Cox proportional hazards regression model (HR: 0.204, 95%CI [0.060-0.689], p for trend value = 0.006). Age, male gender and fasting plasma insulin levels independently predicted baseline serum ALT ≥ 30 IU/L among the population cohort. Augmentation of serum ALT into the weighted Framingham risk score resulted in a considerable net reclassification improvement (NRI) of coronary heart disease (CHD) risk prediction in the study population (NRI = 9.05% (8.01%-10.22%), p value < 0.05). Serum ALT could successfully reclassify about 9% of the population with type 2 diabetes across the CHD-affected and CHD-free categories. Overall, our findings demonstrate a complex and nonlinear relationship for the risk of future CVD by baseline serum ALT levels in patients with type 2 diabetes. Further studies are warranted to confirm whether this complex association could be translated into a clearly visible U or J-shaped figure. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  9. Eventos com aparente risco de vida: incidência, etiologia e investigação clínica = Apparent life-threatening events: incidence, etiology and investigation

    Directory of Open Access Journals (Sweden)

    Anjos, Alessandra Marques dos

    2005-01-01

    Full Text Available Objetivo: Avaliar a incidência, fatores etiológicos e investigação clínica de pacientes com Evento com Aparente Risco de vida (Apparent life-threatening event – ALTE. Métodos: Revisão da literatura através de pesquisa no banco de dados Medline e LILACS entre 1986- 2006 e publicações da Associação Latinoamericana de Pediatria, selecionados a partir de autores com experiência reconhecida em ALTE. Foram revisados 13 artigos de autores renomados além de 3 consensos: americano sobre apnéia infantil e monitorização domiciliar, consenso latinoamericano sobre ALTE e consenso da sociedade européia para estudo e preven- ção de morte infantil. Resultados: A incidência de ALTE descrita foi de 0,6 a 2,27% nos casos revisados. Quanto a etiologia aproximadamente 50% dos casos de ALTE são sintomáticos, sendo mais freqüente doenças do trato gastrointestinal e neurológicas. A investigação deve ser realizada seguindo protocolo padrão e estar direcionada para o diagnóstico da doença de base que definirá o prognóstico do ALTE. Casos recorrentes sem etiologia definida na investigação inicial necessitam de exames complementares, devendo ser considerado o abuso infantil e Munchausen por procura- ção como diagnóstico diferencial. Conclusão: Como o episódio de ALTE pode ser a manifestação inicial de entidades nosológicas diversas recomenda-se sempre sua investigação diagnóstica direcionada para doença de base

  10. Eventos com aparente risco de vida: incidência, etiologia e investigação clínica

    Directory of Open Access Journals (Sweden)

    Nunes, Magda Lahorgue

    2005-01-01

    Full Text Available Objetivo: Avaliar a incidência, fatores etiológicos e investigação clínica de pacientes com Evento com Aparente Risco de vida (Apparent life-threatening event – ALTE. Métodos: Revisão da literatura através de pesquisa no banco de dados Medline e LILACS entre 1986- 2006 e publicações da Associação Latinoamericana de Pediatria, selecionados a partir de autores com experiência reconhecida em ALTE. Foram revisados 13 artigos de autores renomados além de 3 consensos: americano sobre apnéia infantil e monitorização domiciliar, consenso latinoamericano sobre ALTE e consenso da sociedade européia para estudo e prevenção de morte infantil. Resultados: A incidência de ALTE descrita foi de 0,6 a 2,27% nos casos revisados. Quanto a etiologia aproximadamente 50% dos casos de ALTE são sintomáticos, sendo mais freqüente doenças do trato gastrointestinal e neurológicas. A investigação deve ser realizada seguindo protocolo padrão e estar direcionada para o diagnóstico da doença de base que definirá o prognóstico do ALTE. Casos recorrentes sem etiologia definida na investigação inicial necessitam de exames complementares, devendo ser considerado o abuso infantil e Munchausen por procuração como diagnóstico diferencial. Conclusão: Como o episódio de ALTE pode ser a manifestação inicial de entidades nosológicas diversas recomenda-se sempre sua investigação diagnóstica direcionada para doença de base.

  11. The current state of serum biomarkers of hepatotoxicity.

    Science.gov (United States)

    Ozer, Josef; Ratner, Marcia; Shaw, Martin; Bailey, Wendy; Schomaker, Shelli

    2008-03-20

    The level of serum alanine aminotransferase (ALT) activity reflects damage to hepatocytes and is considered to be a highly sensitive and fairly specific preclinical and clinical biomarker of hepatotoxicity. However, an increase in serum ALT activity level has also been associated with other organ toxicities, thus, indicating that the enzyme has specificity beyond liver in the absence of correlative histomorphologic alteration in liver. Thus, unidentified non-hepatic sources of serum ALT activity may inadvertently influence the decision of whether to continue development of a novel pharmaceutical compound. To assess the risk of false positives due to extraneous sources of serum ALT activity, additional biomarkers are sought with improved specificity for liver function compared to serum ALT activity alone. Current published biomarker candidates are reviewed herein and compared with ALT performance in preclinical and on occasion, clinical studies. An examination of the current state of hepatotoxic biomarkers indicates that serum F protein, arginase I, and glutathione-S-transferase alpha (GSTalpha) levels, all measured by ELISA, may show utility, however, antibody availability and high cost per run may present limitations to widespread applicability in preclinical safety studies. In contrast, the enzymatic markers sorbitol dehydrogenase, glutamate dehydrogenase, paraxonase, malate dehydrogenase, and purine nucleoside phosphorylase are all readily measured by photometric methods and use reagents that work across preclinical species and humans and are commercially available. The published literature suggests that these markers, once examined collectively in a large qualification study, could provide additional information relative to serum ALT and aspartate aminotransferase (AST) values. Since these biomarkers are found in the serum/plasma of treated humans and rats, they have potential to be utilized as bridging markers to monitor acute drug-induced liver injury in

  12. The current state of serum biomarkers of hepatotoxicity

    International Nuclear Information System (INIS)

    Ozer, Josef; Ratner, Marcia; Shaw, Martin; Bailey, Wendy; Schomaker, Shelli

    2008-01-01

    The level of serum alanine aminotransferase (ALT) activity reflects damage to hepatocytes and is considered to be a highly sensitive and fairly specific preclinical and clinical biomarker of hepatotoxicity. However, an increase in serum ALT activity level has also been associated with other organ toxicities, thus, indicating that the enzyme has specificity beyond liver in the absence of correlative histomorphologic alteration in liver. Thus, unidentified non-hepatic sources of serum ALT activity may inadvertently influence the decision of whether to continue development of a novel pharmaceutical compound. To assess the risk of false positives due to extraneous sources of serum ALT activity, additional biomarkers are sought with improved specificity for liver function compared to serum ALT activity alone. Current published biomarker candidates are reviewed herein and compared with ALT performance in preclinical and on occasion, clinical studies. An examination of the current state of hepatotoxic biomarkers indicates that serum F protein, arginase I, and glutathione-S-transferase alpha (GSTα) levels, all measured by ELISA, may show utility, however, antibody availability and high cost per run may present limitations to widespread applicability in preclinical safety studies. In contrast, the enzymatic markers sorbitol dehydrogenase, glutamate dehydrogenase, paraxonase, malate dehydrogenase, and purine nucleoside phosphorylase are all readily measured by photometric methods and use reagents that work across preclinical species and humans and are commercially available. The published literature suggests that these markers, once examined collectively in a large qualification study, could provide additional information relative to serum ALT and aspartate aminotransferase (AST) values. Since these biomarkers are found in the serum/plasma of treated humans and rats, they have potential to be utilized as bridging markers to monitor acute drug-induced liver injury in early

  13. Alanine aminotransferase/aspartate aminotransferase ratio is the best surrogate marker for insulin resistance in non-obese Japanese adults

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    Kawamoto Ryuichi

    2012-10-01

    Full Text Available Abstract Background The aim of the present study was to examine how liver markers are associated with insulin resistance in Japanese community-dwelling adults. Methods This cross-sectional study included 587 men aged 58 ± 14 (mean ± standard deviation; range, 20–89 years and 755 women aged 60 ± 12 (range, 21–88 years. The study sample consisted of 998 (74.4% non-obese [body mass index (BMI 2] and 344 (25.6% overweight (BMI ≥25 kg/m2 subjects. Insulin resistance was defined by homeostasis model assessment of insulin resistance (HOMA-IR of at least 2.5, and HOMA-IR and potential confounders were compared between the groups. Areas under the curve (AUC of the receiver operating characteristic curves (ROC were used to compare the power of these serum markers. Results In non-obese subjects, the best marker of insulin resistance was alanine aminotransferase (ALT/aspartate aminotransferase (AST ratio of 0.70 (95% confidence interval (CI, 0.63-0.77. In overweight subjects, AUC values for the ALT/AST ratio and ALT were 0.66 (0.59-0.72 and 0.66 (0.59-0.72, respectively. Multiple linear regression analyses for HOMA-IR showed that ALT/AST ratios were independently and significantly associated with HOMA-IR as well as other confounding factors in both non-obese and overweight subjects. The optimal cut-off point to identifying insulin resistance for these markers yielded the following values: ALT/AST ratio of ≥0.82 in non-obese subjects and ≥1.02 in overweight subjects. In non-obese subjects, the positive likelihood ratio was greatest for ALT/AST ratio. Conclusions In non-obese Japanese adults, ALT/AST ratio may be the best reliable marker of insulin resistance.

  14. Infantile Apparent Life-Threatening Events, an Educational Review

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    Hamed Aminiahidashti

    2015-01-01

    Full Text Available Many physicians have received a frantic call from anxious parents stating that their child had stopped breathing, become limp, or turned blue but then had recovered quickly. An apparent life-threatening event (ALTE is defined as “an episode that is frightening to the observer, and is characterized by some combination of apnea, color change, marked change in muscle tone, choking, gagging, or coughing”. The incidence of ALTE is reported to be 0.05% to 6%. The knowledge about the most common causes and factors associated with higher risk of ALTE could be resulted in a more purposeful approach, improving the decision making process, and benefiting both children and parents. The aim of this review article was to report the epidemiology, etiology, evaluation, management, and disposition of ALTE. Infants with an ALTE might present no signs of acute illness and are commonly managed in the emergency settings that often require significant medical attention; hence, the emergency medicine personnel should be aware of the its clinical importance. There is no specific treatment for ALTE; therefore, the clinical evaluations should be focused on the detection of the underlying causes, which will define the outcomes and prognosis. ALTE is a confusing entity, representing a constellation of descriptive symptoms and signs; in other words, it is not a diagnosis. There are multiple possible etiologies and difficulties in evaluating and managing infants with these events, which are challenges to primary care physicians, emergency medicine specialists, and subspecialty pediatricians. The evaluation of these events in infants includes a detailed history, appropriate physical examination, diagnostic tests guided by obtained clues from the history and physical examination, and observation in the emergency department.

  15. Feasibility and Advantages of Full Thickness Skin Graft from the Anterolateral Thigh.

    Science.gov (United States)

    Shin, Seung-Han; Kim, Chulkyu; Lee, Yong-Suk; Kang, Jin-Woo; Chung, Yang-Guk

    2017-12-01

    Full thickness skin graft (FTSG) gives better outcomes than split thickness skin graft (STSG), but it has the drawback of limited donor sites. Anterolateral thigh (ALT), a popular donor site of STSG, is also a popular donor site of perforator flaps. This area has the advantage of large flap size available with primary closure. Based on this we harvested FTSG instead of STSG from the ALT. We retrospectively reviewed 10 cases of FTSG from the ALT, with the recipient site of foot in 3, ankle in 2, lower leg in 2, forearm in 2, and wrist in 1 patient. In all cases elliptical full thickness skin was harvested from the ALT, and the donor site was closed primarily. The skin was defatted and placed onto the defect with vacuum-assisted closure (VAC). The skin size ranged 7-30 cm in length and 3-12 cm in width. Mean follow up period was 7 months (range, 3-13). FTSG from the ALT provided durable wound coverage, with excellent color and texture matching. Partial (< 20%) graft failure was observed in 1 case, but no additional surgery was necessary. No patient reported donor site pain at postoperative 2 weeks. No donor site complications were encountered. No patient complained a feeling of tension in the thigh at final follow-up. FTSG from the ALT is feasible with the aid of VAC. Considering the skin quality, large skin size available, early pain relief, and little donor site morbidity, the ALT should be revisited as a donor site of FTSG.

  16. Identificação de ponto de corte no nível sérico da alanina aminotransferase para rastreamento da hepatite C em pacientes com insuficiência renal crônica em hemodiálise Identification of the cutoff value for serum alanine aminotransferase in hepatitis C screening of patients with chronic renal failure on hemodialysis

    Directory of Open Access Journals (Sweden)

    Ericson Cavalcanti Gouveia

    2004-02-01

    Full Text Available Pacientes com insuficiência renal crônica em hemodiálise apresentam níveis séricos mais baixos de alanina aminotransferase. Para estabelecer melhor ponto de corte nos níveis de ALT, no diagnóstico da hepatite C, avaliaram-se mensalmente, durante 6 meses os níveis desta enzima em 235 pacientes em hemodiálise, sendo excluídos aqueles que apresentassem média acima do limite superior da normalidade. O ponto de corte foi identificado através da construção de curva ROC. Entre 202 pacientes, 15 (7,4% apresentavam anti-VHC positivo e 187 (92,6% negativo, com média de ALT de 0,7 e de 0,5 do limite superior (p The patients with chronic renal failure in hemodialysis present low levels of serum alanine aminotransferases. In order to establish a better cutoff value for ALT in hepatitis C screening of hemodialysis patients, the ALT levels were measured monthly in 235 patients, being excluded those that presented average above the upper limit of normality. The cutoff value was identified by construction of a ROC curve (receiver operating characteristic. Among 202 patients, 15 (7.4% presented antibodies to hepatitis C virus (anti-HCV and 187 (92.6% were anti-HCV negative , with an ALT average of 0.7 and of 0.5 from ULN (p <0.0001, respectively. The better cutoff value for ALT was at 0.6 from ULN, with sensitivity of 67% and specificity of 75% in anti-HCV screening. These results suggest that ULN of ALT could be reduced for 60% from conventional limit, when we are evaluating patients with CRF in hemodialysis.

  17. HCV carriers with normal aminotransferase levels: “normal” does not always mean “healthy”

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    Claudio Puoti

    2013-04-01

    Full Text Available BACKGROUND Approximately 30% of patients with chronic HCV infection show persistently normal ALT levels (PNALT, and another 40% have minimally raised ALT values. Although formerly referred to as “healthy” or “asymptomatic” HCV carriers, it has now become clear that the majority of these patients have some degree of histological liver damage. Controversies still exist regarding the definition of “persistent” ALT normality, the virological and histological features of these subjects, and the natural history and optimal management of chronic hepatitis C (CHC with normal ALT. Most patients with normal ALT have histologically proven liver damage that may be significant (> F2 in up to 20% of patients, and might progress toward more severe degree of liver fibrosis. A significant proportion of patients (≥ 20% experiences periods of increased serum ALT (flare associated with disease progression. AIM OF THE STUDY The introduction of the new combination therapy of PEG-IFN plus ribavirin allowed response rates higher than 50%, with a favourable risk-benefit ratio also in patients with benign or slow progressive disease. Given the efficacy of the new treatments, which soon became the standard of care for CHC, it has been suggested that the issue of whether or not to treat subjects with PNALT should be re-evaluated. ALT levels may have less importance in deciding who should be treated. Many other factors might influence the decision to treat, such as the age of the patient, HCV genotype, liver histology, patient’s motivation, symptoms, extrahepatic manifestations, comorbid illness. The role of non-invasive tools for the assessment of liver fibrosis (transient hepatic elastography remains to be further validated.

  18. Clinical significance of elevated serum aminotransferases levels in asymptomatic individuals with hepatitis C infection

    International Nuclear Information System (INIS)

    Nafees, M.; Ditta, A.; Jafferi, G.

    2010-01-01

    Background: Hepatitis C is a common and important cause of chronic liver disease that often remains asymptomatic and most of the times discovered incidentally by routine serologic or biochemical testing. Aminotransferases (AST and ALT) reflect alterations in liver function/inflammation in liver diseases. The current study was conducted to examine the utilization and limitations of these biochemical markers in subjects with asymptomatic HCV infection. Aims and Objectives: To find out how many subjects with asymptomatic HCV infection have normal or elevated serum AST and ALT levels. Subjects and Methods: Study Design: Cross sectional. Study Duration: Seven months from November 2008 to July 2009. Study Universe: Services Hospital, Lahore. Study Population: This study included 413 subjects attending the outpatient departments of hospital with minor complaints. The random population of subjects was referred to the clinical laboratory of Services Hospital, Lahore for LFTs, HBsAg and anti-HCV screening from OPD department of the hospital. A total of 413 persons of all ages were analyzed during this study. There were 263 subjects who were sero - positive for anti-HCV (141 females, 122 males; median age 35 +- 11.34 years) and 150 in the control group (80 of them were females and 70 males with median age 32 +- 12.97 years) were sero-negative for both HBsAg and anti - HCV. Subjects Selection Criteria: In this study, only anti - HCV sero - positive subjects were included who was sero - negative for HBsAg or dual infection (both HBsAg and anti - HCV) and not on anti - viral therapy. Control group was sero - negative for both - HBsAg and anti - HCV antibodies. Data Collection: We assayed levels of serum aminotransferases (AST and ALT) and screened blood for HBsAg and anti-HCV. ELISA technique was used for viral hepatitis markers. Results: Out of 263 subjects tested positive for anti-HCV antibodies in their blood, 90.76 % and 87.45 % had elevated AST and ALT levels (ALT = 40 U

  19. Pattern of intraocular pressure reduction following laser trabeculoplasty in open-angle glaucoma patients: comparison between selective and nonselective treatment

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    Almeida Jr ED

    2011-07-01

    Full Text Available Eglailson Dantas Almeida Júnior1, Luciano Moreira Pinto1,2, Rodrigo Antonio Brant Fernandes1,2, Tiago Santos Prata1,31Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil; 2Cerpo Oftalmologia, São Paulo, Brazil; 3Hospital Medicina dos Olhos, São Paulo, BrazilObjective: To compare the pattern of intraocular pressure (IOP reduction following selective laser trabeculoplasty (SLT versus argon laser trabeculoplasty (ALT in open-angle glaucoma (OAG patients, and to investigate the ability of initial IOP reduction to predict mid-term success.Methods: A prospective, nonrandomized, interventional case series was carried out. Consecutive uncontrolled OAG glaucoma patients underwent SLT or ALT; the same preoperative medical regimen was maintained during follow-up. Data collected included age, type of OAG, pre- and postoperative IOP, number of glaucoma medications, and surgical complications. Post-treatment assessments were scheduled at day 1 and 7 and months 1, 3, and 6.Results: A total of 45 patients (45 eyes were enrolled [SLT group (n = 25; ALT group (n = 20]. Groups were similar for age, baseline IOP, and number of glaucoma medications (P ≥ 0.12. We found no significant differences in mean IOP reduction between SLT (5.1 ± 2.5 mmHg; 26.6% and ALT (4.4 ± 2.8 mmHg; 22.8% groups at month 6 (P = 0.38. Success rates (IOP ≤ 16 mmHg and IOP reduction ≥25% at last follow-up visit were similar for SLT (72% and ALT (65% groups (P = 0.36. Comparing the pattern of IOP reduction (% of IOP reduction at each visit between groups, we found a greater effect following SLT compared with ALT at day 7 (23.7% ± 13.7% vs 8.1% ± 9.5%; P < 0.001. No significant differences were observed at other time points (P ≥ 0.32. Additionally, the percentage of IOP reduction at day 7 and at month 6 were significantly correlated in the SLT group (R2 = 0.36; P < 0.01, but not in the ALT group (P = 0.89. Early postoperative success predicted late

  20. AltitudeOmics: Resetting of cerebrovascular CO2 reactivity following acclimatization to high altitude

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    Jui-Lin eFan

    2016-01-01

    Full Text Available Previous studies reported enhanced cerebrovascular CO2 reactivity upon ascent to high altitude using linear models. However, there is evidence that this response may be sigmoidal in nature. Moreover, it was speculated that these changes at high altitude are mediated by alterations in acid-base buffering. Accordingly, we reanalyzed previously published data to assess middle cerebral blood flow velocity (MCAv responses to modified rebreathing at sea level (SL, upon ascent (ALT1 and following 16 days of acclimatization (ALT16 to 5,260 m in 21 lowlanders. Using sigmoid curve fitting of the MCAv responses to CO2, we found the amplitude (95% vs. 129%, SL vs. ALT1, 95% confidence intervals (CI [77, 112], [111, 145], respectively, P=0.024 and the slope of the sigmoid response (4.5 vs. 7.5 %/mmHg, SL vs. ALT1, 95% CIs [3.1, 5.9], [6.0, 9.0], respectively, P=0.026 to be enhanced at ALT1, which persisted with acclimatization at ALT16 (amplitude: 177%, 95% CI [139, 215], P<0.001; slope: 10.3 %/mmHg, 95% CI [8.2, 12.5], P=0.003 compared to SL. Meanwhile, the sigmoidal response midpoint was unchanged at ALT1 (SL: 36.5 mmHg; ALT1: 35.4 mmHg, 95% CIs [34.0, 39.0], [33.1, 37.7], respectively, P=0.982, while it was reduced by ~7 mmHg at ALT16 (28.6 mmHg, 95% CI [26.4, 30.8], P=0.001 vs. SL, indicating leftward shift of the cerebrovascular CO2 response to a lower arterial partial pressure of CO2 (PaCO2 following acclimatization to altitude. Sigmoid fitting revealed a leftward shift in the midpoint of the cerebrovascular response curve which could not be observed with linear fitting. These findings demonstrate that there is resetting of the cerebrovascular CO2 reactivity operating point to a lower PaCO2 following acclimatization to high altitude. This cerebrovascular resetting is likely the result of an altered acid-base buffer status resulting from prolonged exposure to the severe hypocapnia associated with ventilatory acclimatization to high altitude.