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  1. Vadim Loktev's 70th birthday

    Directory of Open Access Journals (Sweden)

    Editorial Board

    2015-06-01

    Full Text Available This year Vadim Loktev, a well-known scientist, prominent theoretical physicist, talented lecturer, organizer of scientific research and activity celebrates his 70th birthday. Vadim Loktev was born on May, 3, 1945 in Kyiv (Ukraine; his parents were professional employees. He studied at the Department of Physics of Taras Shevchenko State University (Kyiv. After graduation from the university in 1968 he was a postgraduate student at the Institute for Theoretical Physics of the Academy of Sciences of the Ukrainian SSR [now Bogolyubov Institute for Theoretical Physics of the National Academy of Sciences of Ukraine (NASU] in 1968-1971. He has been working at this institute since 1967 up to the present time now occupying the position of Head of the Department of Nonlinear Condensed Matter Physics. In 1971 V. Loktev defended his Ph.D. thesis under the supervision of the world-renowned scientist A. Davydov; in 1983 he defended his D.Sc. thesis. In 1997 he obtained title of Professor. The same year V. Loktev was elected a corresponding member and in 2003 he was elected a full member of the NASU.

  2. Vadim Kotelnikovi tugevus on loovus / Marjatta Pietilä

    Index Scriptorium Estoniae

    Pietilä, Marjatta

    2004-01-01

    E-coaching teenuseid pakkuvast ülemaailmsest ettevõtete ketist TEN3, firmast Centre for Entrepreneurial Creativity and Systemic Innovation ning nende loojast majandusdoktor Vadim Kotelnikovist. Lisa: Vadim Kotelnikov

  3. Redox Pioneer: Professor Vadim N. Gladyshev.

    Science.gov (United States)

    Hatfield, Dolph L

    2016-07-01

    Professor Vadim N. Gladyshev is recognized here as a Redox Pioneer, because he has published an article on antioxidant/redox biology that has been cited more than 1000 times and 29 articles that have been cited more than 100 times. Gladyshev is world renowned for his characterization of the human selenoproteome encoded by 25 genes, identification of the majority of known selenoprotein genes in the three domains of life, and discoveries related to thiol oxidoreductases and mechanisms of redox control. Gladyshev's first faculty position was in the Department of Biochemistry, the University of Nebraska. There, he was a Charles Bessey Professor and Director of the Redox Biology Center. He then moved to the Department of Medicine at Brigham and Women's Hospital, Harvard Medical School, where he is Professor of Medicine and Director of the Center for Redox Medicine. His discoveries in redox biology relate to selenoenzymes, such as methionine sulfoxide reductases and thioredoxin reductases, and various thiol oxidoreductases. He is responsible for the genome-wide identification of catalytic redox-active cysteines and for advancing our understanding of the general use of cysteines by proteins. In addition, Gladyshev has characterized hydrogen peroxide metabolism and signaling and regulation of protein function by methionine-R-sulfoxidation. He has also made important contributions in the areas of aging and lifespan control and pioneered applications of comparative genomics in redox biology, selenium biology, and aging. Gladyshev's discoveries have had a profound impact on redox biology and the role of redox control in health and disease. He is a true Redox Pioneer. Antioxid. Redox Signal. 25, 1-9.

  4. Physics and mathematics of strings memorial volume for Vadim Knizhnik

    CERN Document Server

    Polyakov, A M; Brink, Lars

    1990-01-01

    Vadim Knizhnik was one of the most promising theoretical physicists in the world. Unfortunately, he passed away at the very young age of 25 years. This memorial volume is to honor his contributions in Theoretical Physics. This is perhaps one of the most important collections of articles on the theoretical developments in String Theory, Conformal Field Theory and related topics. It consists of contributions from world-renowned physicists who have met Vadim Knizhnik personally and whom the late Knizhnik really respected. The contributions are systematic and pedagogical in format.

  5. Kvaliteedimärk näitab sihikindlust / Vadim Mitroškin, Eda Anton ; küsitlenud Kaidi Holm

    Index Scriptorium Estoniae

    Mitroškin, Vadim

    2006-01-01

    Elukestva Õppe Arendamise Sihtasutuse INNOVE eestvedamisel korraldatud kutsekoolide kvaliteediauhinna konkursist. Küsimustele vastavad Võrumaa Kutsehariduskeskuse kvaliteedidirektor Vadim Mitroškin ja Tartu Kutsehariduskeskuse kvaliteedijuht Eda Anton

  6. Koolis töötada on ikka veel põnev / Ülo Tikk ; kommenteerivad: Vadim Rõbtsov, Tatjana Antsma, Olga kalju

    Index Scriptorium Estoniae

    Tikk, Ülo, 1941-

    2009-01-01

    Vestlusest Tallinna Mustamäe Reaalgümnaasiumi eesti keele ja kirjanduse õpetajast-metoodiku Olga Ivanovaga. Õpetajast kõnelevad ka vilistlane Vadim Rõbtsov, lapsevanem Tatjana Antsma, reaalgümnaasiumi direktor Olga Kalju

  7. Moja Nadja ujehhala / Vadim Retshkalov

    Index Scriptorium Estoniae

    Retshkalov, Vadim

    2008-01-01

    Eldar Rjazanovi menufilmi "Saatuse iroonia ehk Hüva leili!" (1975) järjefilm "Saatuse iroonia: lugu läheb edasi" ("Ironija sudbõ. Prodolzhenije") : režissöör Timur Bekmambetov : Venemaa 2007. Uus film ei haaku vanaga selle kultuurikihi puudumise tõttu, mis peegeldub vanas näiteks Mikael Tariverdijevi muusika ja seal kasutatud vene poeesia tõttu

  8. Rahvussuhted ja ebavõrdne kohtlemine = Interethnic relations and unequal treatment = Mezhetnitsheskije otnoshenija i neravnoje obrashtshenije / Vadim Poleshtshuk, Aleksei Semjonov

    Index Scriptorium Estoniae

    Poleshtshuk, Vadim

    2006-01-01

    Eestlaste ja mitte-eestlaste suhtumine etnilisse diskrimineerimisse, seda nii rahvusgruppidega seonduvalt kui ka isikliku kogemuse taustal. Hinnang olukorrale Eesti ühiskonnas, rahvussuhetele, rahvus- ja integratsioonipoliitikale, ajaloo tajumine ja ühiskonna arengu mudelite valik. Lisa: Tabelid

  9. Privaatautonoomia piiramine hinna ja saadava väärtuse vahekorra määramisel : [magistritöö] / Vadim Doronin ; Tartu Ülikool, õigusteaduskond ; juhendaja: Irene Kull

    Index Scriptorium Estoniae

    Doronin, Vadim

    2010-01-01

    Privaatautonoomia põhimõttest ja õigluse argumendist lepingu sisu hindamisel. Ajaloolises perspektiivis privaatautonoomia põhimõttest ning hinna ja saadava väärtuse vahekorrast lepingus. Liigkasuvõtmisest

  10. "Zolotoi Oven" ishtshet svojego obladatelja / Valeri Kuznetsov

    Index Scriptorium Estoniae

    Kuznetsov, Valeri

    2003-01-01

    Parima filmi auhinnale "Zolotoi Oven" võistlevad Andrei Zvjagintsevi "Tagasitulek" ("Vozvrashtshenije"), Vadim Abdrashitovi "Magnettormid" ("Magnitnõje buri"), Gennadi Sidorovi "Vanaeided" ("Staruhhi") ja Pjotr Buslovi "Bumer"

  11. Vissarioni parem käsi on Eestis

    Index Scriptorium Estoniae

    2015-01-01

    Dokumentaalfilmi „Kristus elab Siberis” Tallinnas ja Tartus toimuvatel erilinastustel saab kohtuda usuliidri ja enda väitel Kristuse taaskehastuse Vissarioni parema käe, endise rokkbändi Integral laulja Vadim Redkiniga

  12. [History of pedagogy and educational sciences in the Baltic countries from 1940 to 1990. An overview] / Mare Oja

    Index Scriptorium Estoniae

    Oja, Mare, 1960-

    2014-01-01

    Arvustus: History of pedagogy and educational sciences in the Baltic countries from 1940 to 1990. An overview. Hrsg. im Auftrag der Baltic Association of Historians of Pedagogy von Vadim Rõuk und Vidimantas Raudys. Verlag RaKa. Riga 2013

  13. Kaubamajast välja jooksid sõbralikud väed... / Mari Sobolev

    Index Scriptorium Estoniae

    Sobolev, Mari, 1968-

    2002-01-01

    Uuema vene kunsti näitus "Ristumised" Hansapanga galeriis. Eksponeeritud Dmitri Gutovi ja grupi "Radek" video "Demonstratsioon", Vadim Zahharovi scratch-dokfilm "Unustuse järv" ja Sergei Shutovi installatsioon "Abakus"

  14. Endine turujuht end süüdi ei tunnistanud / Hannes Krause

    Index Scriptorium Estoniae

    Krause, Hannes

    2005-01-01

    Vadim Polishtshuk, keda süüdistatakse koos kahe kaaslasega Mait Metsamaa mõrvaprotsessi peamise tunnistaja ähvardamise ja mõjutamise katses, ei tunnistanud end 19. septembril Tallinna linnakohtus alanud protsessil süüdi

  15. Ozero kormit no s perebojami / Jevgeni Ashihmin

    Index Scriptorium Estoniae

    Ashihmin, Jevgeni

    2007-01-01

    Kalapüügifirma OÜ Peipus direktor Vadim Ivanov hindab kriitiliselt keskkonnaministeeriumi ja põllumajandusministeeriumi otsuseid, mis reguleerivad kalapüüki Peipsi järvest ja soovitab rohkem usaldada Peipsi Kalurite Liidu arvamust

  16. Endine KGB-lane pürib taas Narvas volikokku / Toomas Kümmel

    Index Scriptorium Estoniae

    Kümmel, Toomas

    2002-01-01

    KGB-mineviku varjamise pärast Keskerakonnast välja visatud Valdek Lans (Vadim Tomilov) astus taas erakonda ja kandideerib kohalikel valimistel. Kommenteerib Narva linnavolikogu esinaine Elsa Suikanen

  17. Mats valib Paides kuningaid ja põletab mõisaid / Tiina Laanem

    Index Scriptorium Estoniae

    Laanem, Tiina

    2001-01-01

    Kati Murutari "Eestlase neli kuningat" peaproovilt (lavastaja Ivo Eensalu, muusika autor Siiri Sisask, kunstnik Vadim Fomitshev). Esietendus 28. juunil Paide Vallimäel. Vabaõhuetenduses teevad kaasa tuntud näitlejad ja ansambel Ultima Thule

  18. Bog rodom iz detstva / Jelena Skulskaja

    Index Scriptorium Estoniae

    Skulskaja, Jelena, 1950-

    2007-01-01

    Eldar Rjazanovi eluloofilm muinasjutuvestja Hans Christian Anderseni elust "Andersen. Elu ilma armastuseta" ("Andersen. Zhizn bez ljubvi"): stsenarist Irakli Kvirikadze : operaatorid Jevgeni Guslinski ja Vadim Alissov : helilooja Aleksei Rõbnikov : nimiosas Vanja Haratjan, Stanislav Rjadinski, Sergei Migitsko

  19. Physical metallurgy: Scientific school of the Academician V.M. Schastlivtsev

    Science.gov (United States)

    Tabatchikova, T. I.

    2016-04-01

    This paper is to honor Academician Vadim Mikhailovich Schastlivtsev, a prominent scientist in the field of metal physics and materials science. The article comprises an analysis of the topical issues of the physical metallurgy of the early 21st century and of the contribution of V.M. Schastlivtsev and of his school to the science of phase and structural transformations in steels. In 2015, Vadim Mikhailovich celebrates his 80th birthday, and this paper is timed to this honorable date. The list of his main publications is given in it.

  20. "Medvezhii" ugol Jevrosojuza / Jevgeni Ashihmin

    Index Scriptorium Estoniae

    Ashihmin, Jevgeni

    2007-01-01

    Regionaalminister Vallo Reimaa, Ida-Virumaa maavanem Riho Breivel, Kirde-Eesti piirivalveülem Aimar Kess, Alajõe vallavanem Natalja Varkki, Vasknarva külavanem Vadim Ivanov ja kohalik aktivist Aleksandr Petuhhov arutasid Alajõe valla ja Vasknarva küla probleeme

  1. Seletamatu ja koomiline sajandilõpp / Sulev Teinemaa

    Index Scriptorium Estoniae

    Teinemaa, Sulev, 1947-

    1998-01-01

    Mängufilmid II Pimedate Ööde Filmifestivalil : "Must kass, valge kass" ("Crna mack, beli macor"), režissöör Emir Kusturica : Jugoslaavia - Prantsusmaa 1998; "Tantsija aeg" ("Vremja tantsora"), režissöör Vadim Abdrashitov : Venemaa 1997; "Helge homne" ("The Sweet Hereafter"), režissöör Atom Egoyan : Kanada 1997

  2. Most "Druzhba" priobretajet politisheskoje znatshenije / Konstantin Vikentejev

    Index Scriptorium Estoniae

    Vikentejev, Konstantin

    2005-01-01

    Eesti ja Venemaa välisministrite Urmas Paeti ja Sergei Lavrovi kohtumisest Sloveenias, kus kinnitati ka vajadust Sõpruse sild rekonstrueerida. Arvamust avaldavad: Ago Silde, Sergei Jastrzhembski, Arnold Rüütel, Margus Leivo, Jaanus Õunapuu, Tiit Vähi, Ain Uiga, Vadim Gustov, Riho Sõrmus

  3. Sissejuhatus suure kirjaniku loomingusse : Edgar Allan Poe' väändunud maailm / Aare Ermel

    Index Scriptorium Estoniae

    Ermel, Aare, 1957-2013

    2001-01-01

    Prantsusmaa-Itaalia 1968.a. ühisfilm "Erakordsed lood" ("Histoires extraordinaires"), mis koosneb Edgar Allan Poe kolme novelli ekraniseeringutest : "Metzengerstein" (režissöör Roger Vadim), "William Wilson" (režissöör Louis Malle) ja "Toby Dammit" (režissöör Federico Fellini). Ka : Nädal nr. 25, lk. 14

  4. 78 FR 66989 - Designation of Six Individuals and Four Entities Pursuant to Executive Order 13581, “Blocking...

    Science.gov (United States)

    2013-11-07

    ...). The Order was effective at 12:01 a.m. eastern daylight time on July 25, 2011. In the Order, the.... ``GRISHA''), Phuket, Thailand; DOB 16 Jul 1962; POB Sochi, Russia (individual) [TCO]. 3. LYALIN, Vadim... Marine Tower, P.O. Box 1102, Dubai, United Arab Emirates; DOB 30 Sep 1973; Passport 4510935440 (Russia...

  5. "Andke vene kunstnikele vaid toetuspunkt..." : intervjuu Moskva Riikliku Kaasaegse Kunsti Keskuse teaduri Irina Gorlovaga / Irina Gorlova ; interv. Reet Varblane

    Index Scriptorium Estoniae

    Gorlova, Irina

    2002-01-01

    Irina Gorlova ja Leonid Bazhanovi kureeritud vene kunstnike Dmitri Gutovi, Sergei Shutovi ja Vadim Zahharovi näitusest "Ristumised" Hansapanga galeriis. I. Gorlova suhtumisest 1960ndate avangardistide põlvkonda, Ülo Soosterist, Ilja Kabakovist, sürrealismist ja praegusest vene kunstist, Oleg Kulikust, Aleksandr Brenerist, Aleksandr Ponomarjovist

  6. Kaitstud magistri- ja doktoritööd 2014

    Index Scriptorium Estoniae

    2015-01-01

    Magistritööd kaitsesid: Ekaterina Ermolaeva, Helena Haller, Kadri Kallast, Ville-Matti Aleksi Kataja, Laura Kiiroja, Alina-Ruxanda Mircea, Tatjana Pilipoveca, Liina Sieberk, Katsiaryna Suryna, Fatemeh Tavakoli, Ele Viskus; doktoritööd kaitses Vadim Verenitš

  7. Värdjatest, kui mitte muust / Karlo Funk

    Index Scriptorium Estoniae

    Funk, Karlo, 1971-

    1999-01-01

    Mängufilmid "Tantsija aeg" ("Vremja tantsora") : Stsenarist Aleksandr Mindadze : režissöör Vadim Abdrashitov : Venemaa 1997 ja "Värdjatest ja inimestest" ("Pro urodov i ljudei") : Stsenarist ja režissöör Aleksei Balabanov : Venemaa - Ameerika Ühendriigid 1998

  8. Volshebnõi fonar Rozhe Vadima / Olga Kalmõkova

    Index Scriptorium Estoniae

    Kalmõkova, Olga

    2001-01-01

    Kohtumisel autoriga räägib tuntud prantsuse filmirežissöör Roger Vadim (1928-2000) oma võluvatest abikaasadest : Brigitte Bardot'st (1934), Catherine Deneuve'st (1943), Jane Fondast (1937) ja Marie-Christine Barrault'st (1944)

  9. Letter From... Novosibirsk--Where music is part of the infrastructure

    NARCIS (Netherlands)

    Kurzbauer, H.

    2014-01-01

    Kurzbauer reports on the inaugural Trans-Siberian Art Festival, held March 31-April 12, 2014 in Novosibirsk, Russia. Founded by Russian-born Belgian violinist Vadim Repin, the festival is his gift to his hometown. Sometimes called "the Chicago of Russia," Novosibirsk is known as a city built on

  10. From my Home: Dvarionas: Elegie; Pärt: Fratres / Patric Wiklacz

    Index Scriptorium Estoniae

    Wiklacz, Patric

    1997-01-01

    Uuest heliplaadist "From my Home: Dvarionas: Elegie; Pärt: Fratres; Barkauskas: Partita; Vasks: Musica Dolorosa; Pelecis: Concerto for Violin, Piano and String Orchestra, "Neverthless"; Plakidis: Two Grasshopper Dances; Tüür: Conversio. Deutsche Kammerphilharmonie, Gidon Kremer (violon), Vadim Sacharov (piano)" Teldec 0630-14654-2 (79 minutes:DDD)

  11. The Relationship between Zhedanov's Algebra AW(3) and the Double Affine Hecke Algebra in the Rank One Case

    NARCIS (Netherlands)

    Koornwinder, T.H.

    2007-01-01

    Vadim Kuznetsov Memorial Issue on Integrable Systems and Related Topics Abstract Zhedanov's algebra AW(3) is considered with explicit structure constants such that, in the basic representation, the first generator becomes the second order q-difference operator for the Askey-Wilson polynomials. It is

  12. Cooperation-Induced Topological Complexity: A Promising Road to Fault Tolerance and Hebbian Learning

    Science.gov (United States)

    2012-03-16

    Information Science Directorate, United States Army Research Office, Durham, NC, USA 4 Istituto di Fisiologia Clinica del Consiglio Nazionale delle...Vadim Uritsky, Catholic University of America at NASA Goddard Space Flight Center, USA *Correspondence: Paolo Allegrini , Istituto di Fisiologia Clinica

  13. Festival : "Tjomnõje notshi" Tallinna / Artur Veeber

    Index Scriptorium Estoniae

    Veeber, Artur

    1998-01-01

    II Pimedate Ööde Filmifestival 2.-6.dets. : Ülevaade festivalil toimunust ning lühiintervjuud festivalil osalenud režissööride Vadim Abdrašitovi, Zaza Urušadze ja stsenaristi Amiran Tshitshinadzega

  14. V poiskah formulõ stshastja / Jelena Usatsheva

    Index Scriptorium Estoniae

    Usatsheva, Jelena

    2006-01-01

    Kirjanik Viktoria Tokareva koostöös stsenaristi Julia Damskeriga kirjutasid stsenaariumi 8-osalisele teleseriaalile "Armastusest tähtsam", mis on kirjaniku nelja novelli ekraniseering. Iga novell on kahes osas, režissöör Vadim Ostrovski. Seriaalist ja võtteplatsil toimuvast

  15. Любителей кино ждут на показе российского фильма

    Index Scriptorium Estoniae

    2009-01-01

    Vene filmirežissööri Igor Minajevi, kes elab ja töötab Prantsusmaal, mängufilmi "Kaugel Sunset-Boulevard'ist" näeb täna Tallinnas Vene Kultuurikeskuses. Vaatajatega kohtuvad režissöör, helilooja Vadim Šer ja näitleja Lembit Ulfsak

  16. Кино о закулисье советского кино / Андрей Бабин

    Index Scriptorium Estoniae

    Бабин, Андрей

    2009-01-01

    Vene filmirežissööri Igor Minajevi, kes elab ja töötab Prantsusmaal, mängufilm "Kaugel Sunset-Boulevard'ist" linastus 31. märtsil Tallinnas Vene Kultuurikeskuses. Vaatajatega kohtusid režissöör, helilooja Vadim Šer ja näitleja Lembit Ulfsak

  17. Rjazanov võpustil "Andersena" / Nikita Kartsev

    Index Scriptorium Estoniae

    Kartsev, Nikita

    2006-01-01

    Vene režissööril Eldar Rjazanovil esilinastus Moskva kinomajas eluloofilm muinasjutuvestja Hans Christian Anderseni elust "Andersen. Elu ilma armastuseta" ("Andersen. Zhizn bez ljubvi"). Stsenaarium valmis Rjazanovil koostöös Irakli Kvirikadzega, operaatorid olid Jevgeni Guslinski ja Vadim Alissov, helilooja Aleksei Rõbnikov. Nimiosas on kolm näitlejat - Vanja Haratjan, Stass Rjadinski, Sergei Migitsko

  18. Skazka dlja vzroslõhh / Jeva Zhdanovskaja

    Index Scriptorium Estoniae

    Zhdanovskaja, Jeva

    2007-01-01

    Eldar Rjazanovi eluloofilm muinasjutuvestja Hans Christian Anderseni elust "Andersen. Elu ilma armastuseta" ("Andersen. Zhizn bez ljubvi"): stsenarist Irakli Kvirikadze : operaatorid Jevgeni Guslinski ja Vadim Alissov : helilooja Aleksei Rõbnikov : nimiosas Vanja Haratjan, Stanislav Rjadinski, Sergei Migitsko : Venemaa, 2006. Režissöör ja näitlejad S. Migitsko ja A. Babenko filmist

  19. Idanaaber valimiste vahel / Urmas Kiil

    Index Scriptorium Estoniae

    Kiil, Urmas

    2003-01-01

    Autor arutleb ajakirjas New York Reveiw of Books ilmunud Briti ajakirjaniku Robert Cottrelli artikli "Putin's trap" üle, milles on retsenseeritud Vadim Volkovi raamatut "Vägivaldsed ärimehed: jõu kasutamine vene kapitalismi loomisel", Jegor Gaidari raamatut "Riik ja revolutsioon". Nn. hüdraulilisest ühiskonnast

  20. Viis armastuslugu suurel ekraanil / Tristan Priimägi

    Index Scriptorium Estoniae

    Priimägi, Tristan, 1976-

    2008-01-01

    Viis näidet filmiajaloost, kus režissööri ja staari vahel on tunded : Roger Vadim ja Tema Naised, Werner Herzog ja Klaus Kinski, Federico Fellini ja Anita Ekberg, Quentin Tarantino ja Uma Thurman, Rainer Werner Fassbinder ja Mr/Mrs X

  1. Eesti Memento Liidu tööst nimekirjade koostamisel aastail 1989-2004 / Peep Varju

    Index Scriptorium Estoniae

    Varju, Peep

    2007-01-01

    1991. aasta sügisel sõlmiti leping Eesti Riigiarhiivi ja Vene Föderatsiooni Arhiiviameti vahel. 1992. aasta juulis alustas tööd Okupatsioonide repressiivpoliitika uurimise riiklik komisjon (ORURK). ORURKi andmete võrdlus Memento tulemustega. Olulise tähtsusega andmete kogumisel oli töine kontakt Tomskis elava Vadim Maķejeviga, kelle abiga avanesid täies ulatuses kohalikud arhiivid. Uurimistöö tulemusena ilmunud väljaannetest

  2. Cido fruit juice entangled in quality scare

    Index Scriptorium Estoniae

    2005-01-01

    Leedu Veterinaar- ja Toidulabor avastas Lätis toodetud Cido greibimahlakontsentraadist 210 mg/kg mürkainet, mis on üle nelja korra lubatud määrast rohkem mürkainet. Cido turundusdirektori Dmitrijs Tairovsi sõnul leiti Lätis ja Saksamaal tehtud testide põhjal ainet tunduv alt vähem. Ettevõtte tegevdirektor Vadims Vlasovs kahtlustab Leedu konkurente

  3. Moda na grazhdanstvo / Roman Starapopov

    Index Scriptorium Estoniae

    Starapopov, Roman

    2008-01-01

    Autor käsitleb statistikat Eesti kodakondsuse taotlemise, kodakondsusest loobumise, eesti keele eksamile registreerimise ning eksami sooritamise kohta, samuti Vene kodakondsusest loobumise kohta. Venemaa Eesti-saatkonna andmeil vähenes Vene kodakondsusest loobumine 2007. a. üle 20%, aprillisündmuste järel kasvas 2007. a. lõpuni Vene kodakondsuse taotlejate hulk kaks korda. Diagramm, tabel. Kommenteerib Vadim Belobrovtsev

  4. Muulane või surmasõlm / Vaapo Vaher

    Index Scriptorium Estoniae

    Vaher, Vaapo, 1945-

    2007-01-01

    Tutvustus: Ivinskaja, Olga. Aastad Boriss Pasternakiga, ehk, Aja vangis / tlk. Vilma Matsov. Tallinn : Varrak, 2006 ; Baranov, Vadim. Maksim Gorki. Elu ja surma saladus / tlk. Jüri Pärni. Tallinn : Kunst, 2006 ; Troyat, Henri. Aleksander III : lumetsaar / tlk. Jana Porila. Tallinn : Eesti Raamat, 2006 ; Runnel, Hando. Viru veri ei värise. [Tartu] : Ilmamaa, 2006 ; Pärnik, Ylo M. Dr. Julius von Scultz-Bertram. Tartu : Ilmamaa, 2006

  5. Veebruarikuus 2000 lahkunuid / Aare Ermel

    Index Scriptorium Estoniae

    Ermel, Aare, 1957-2013

    2000-01-01

    Surid : Autant-Lara, Claude prantsuse režissöör (5.08.1903-5.02.2000), Vadim, Roger ukraina päritolu prantsuse režissöör (26.01.1928-11.02.2000), Kedrova, Lila vene päritolu prantsuse näitlejanna (1918-16.02.2000), Martelli, Otello itaalia filmioperaator (19.05.1903-20.02.2000)

  6. Små og Store Utopier: Arkiv og avantgarde i Moskvakonceptualisternes kunst, 1970-90

    DEFF Research Database (Denmark)

    Greve, Charlotte

    2006-01-01

    In recent years, the unofficial culture of the Soviet Union is becoming official and material hidden in official Soviet and unofficial private archives is now resurfacing; Russian modern cultural history is being (re-)written. In this process, the active preservation and revaluation of the past...... by the unofficial artists is important. As a member of the Moscow Conceptualist School (1970-90), Vadim Zacharov documented and collected material on this group of unofficial Moscow artists in a personal archive. Thus, the artist becomes an archivist, but the archive is also turned into art. In this article...... actively participate in the co-writing of art history....

  7. Kivistatud kurjad teod / Peeter Pere

    Index Scriptorium Estoniae

    Pere, Peeter, 1957-

    2011-01-01

    Kommunismiohvrite memoriaali ideekavandite võistlusest, võidutöödest. I-II preemia - märgusõna Vest (autorid Armin Valter, Joel Kopli). I-II preemia - märgusõna Mälutulbad (autor Koit Ojaliiv). Eripreemiad - märgusõna Otsuste rand (autorid Roland Reemaa, Laura Linsi), märgusõna Introvert (autorid Urmas Paul, Martin Lepplaan, Evelin Reimand, Martin Noorväli), märgusõna Padakonn (autorid Vadim Fomitsev, Mart Liho, Ekke Väli)

  8. Presidendi autojuht virutas riigilt 33 miljonit krooni / Tarmo Vahter

    Index Scriptorium Estoniae

    Vahter, Tarmo, 1970-

    2009-01-01

    Riiulifirmadega riiki petnud tartlane Vadim Šamrai peab maksu- ja tolliametile tagastama ligi 33,3 miljonit krooni, ühtlasi määras kohus talle 3 aasta ja 2 kuu pikkuse vanglakaristuse. 2006. a. presidendivalimiste kampaania ajal sõidutas V. Shamrai renditud bussiga Toomas Hendrik Ilvest ja tema meeskonda. Juuresoleval fotol V. Shamrai 22. sept. 2006 koos T. H. Ilvese, proua Evelin Ilvese, Luukas Ilvese ja Eesti Televisiooni saatejuhi Andres Kuusega. Vt. ka vastukaja artiklile: Eesti Ekspress 31. dets. 2009, lk. A8, pealk.: Ilves kinkis kriminaalist autojuhile raamatu. Presidendi kantselei kinnitusel sattus V. Shamrai tulevast presidenti sõidutama transpordiettevõtja Tiit Pruuli vahendusel

  9. Laureatõ premii "Zolotoi Oven"

    Index Scriptorium Estoniae

    2003-01-01

    Parima filmi auhinna "Zolotoi Oven" võitis Andrei Zvjagintsevi "Tagasitulek" ("Vozvrashtshenije"), Vadim Abdrashitovi "Magnettormid" ("Magnitnõje buri") sai parima režissööri ja parima stsenaristi auhinna (Aleksandr Mindadze), Pjotr Buslovi "Bumer" sai vaid muusikaauhinna (Sergei Shnurov). Parim meesnäitleja oli Viktor Suhhorukov ("Vaene, vaene Paul") ja naisnäitleja Maria Zvonarjeva A. Proshkini "Trios". A. Sokurovi "Isa ja poeg" sai vaid kunstnikuauhinna (Natalja Kotshergina). Inna Tshurikova sai kõrvalosa auhinna ("S: Govoruhhini "Blagoslovite zhenshtshinu")

  10. Articles in this issue, v.1

    CERN Document Server

    Joint Institute for Nuclear Research. Dubna

    1999-01-01

    Content:At the Laboratories of JINR. A New Element Synthesized. NA48 Experiments: First Results. Stress Investigations by Neutron Fourier Diffractometry Method (by G.D.Bokuchava). Session of the JINR Scientific Council. Prizes. JINR Prizes for 1998. B.Pontecorvo Prize. Meetings of the JINR PACs. Scientific Cooperation. JINR Directorate's Information. P.L.Kapitsa Medal. Visits. Meeting with the Chairman of the State Duma. Russia's New Plenipotentiary to JINR. Jubilees. I.M.Frank Memorial Events. N.A.Chernikov's Jubilee. At JINR's UC. In Memory of a Colleague. Soloviev Vadim Georgievich. Nominations. New Publications. Schedule of JINR Meetings.

  11. Päästeamet tunnustas elupäästjaid ja jagas aumärke / Reimo Raja

    Index Scriptorium Estoniae

    Raja, Reimo

    2010-01-01

    2010. a. septembris autasutas siseminister Marko Pomerants ja Päästeameti peadirektor elupäästjaid. Pikemalt päästeoperatsioonidest, kus päästjateks olid Mehis Kont, Aleksei Rožkov, Kertu Rannak, Georg Alema, Hanna-Maria Puhke, Merit Kalamägi, Toomas Pagil, Janek Lember, Maiken Nelis, Markku Eklund, Olaf Orgs, Eduard Borovik, Vadim Kaminski, Eduard Bemidas, Ants Viirmann, Olesja Nekrassova, Konstantin Fjodorov, Ramid Niftalyev, Konstantin Gerassimov, Tarvo Turja, Aleksander Beljajev, Kalle Närska, Margus Matto, Igor Koževnikov, Vyacheslav Didenko, Boriss Mihhejev, Alexander Berezko, Aleksander Küttim, Andrei Larin, Aleksandr Bolšakov, Andrei Põld

  12. PAR EXEMPLE... LA CITATION

    Directory of Open Access Journals (Sweden)

    Maria Anca FILIP

    2012-05-01

    Full Text Available The aim of this paper is to discuss the relationship between the notion of “example” – as it is presented in the French dictionaries, and the manner in which it may be interpreted from the theoretical perspective suggested by Aristotle and Perelman & Olbrechts-Tyteca, respectively. We will also suggest a possible expression of the “example” in the form of “quotation”, and will support this view with evidence found in our corpus of data represented by the political discourses delivered by C. Vadim Tudor, J.- M. Le Pen and/or J. Haider, approximately in the same period. This perspective would expand the rhetorical interpretation of the “example”, including the “quotational” reading as well.

  13. Penetration of Cosmic Rays into Dense Molecular Clouds: Role of Diffuse Envelopes

    Science.gov (United States)

    Ivlev, A. V.; Dogiel, V. A.; Chernyshov, D. O.; Caselli, P.; Ko, C.-M.; Cheng, K. S.

    2018-03-01

    A flux of cosmic rays (CRs) propagating through a diffuse ionized gas can excite MHD waves, thus generating magnetic disturbances. We propose a generic model of CR penetration into molecular clouds through their diffuse envelopes, and identify the leading physical processes controlling their transport on the way from a highly ionized interstellar medium to the dense interior of the cloud. The model allows us to describe a transition between a free streaming of CRs and their diffusive propagation, determined by the scattering on the self-generated disturbances. A self-consistent set of equations, governing the diffusive transport regime in an envelope and the MHD turbulence generated by the modulated CR flux, is characterized by two dimensionless numbers. We demonstrate a remarkable mutual complementarity of different mechanisms leading to the onset of the diffusive regime, which results in a universal energy spectrum of the modulated CRs. In conclusion, we briefly discuss implications of our results for several fundamental astrophysical problems, such as the spatial distribution of CRs in the Galaxy as well as the ionization, heating, and chemistry in dense molecular clouds. This paper is dedicated to the memory of Prof. Vadim Tsytovich.

  14. The Baltic-Pontic region in the Europe-Eurasia dual system

    Directory of Open Access Journals (Sweden)

    Ilyin Mikhail

    2012-03-01

    Full Text Available This article considers the Baltic-Pontic Sea region not only as a geographical space of Intermarium (Międzymorze, Tarpjūris etc. but also as Intermundium or the interface of European and Russian (Eurasian civilization. The study sets out to clarify the logic of changing patterns shaping this geopolitical area. To this end, the concept of the Baltic-Pontic conflict system proposed by Vadim Tsymbursky is applied and further developed. In contrast to his agent-focused vehicle of analysis disclosing the power interactions in Intermarium, the authors advance an alternative structure-focused model of the Baltic-Pontic system (BPS as a multidimensional evolving space of heterogeneous interactions, which include cooperation. The authors suggest applying the BPS models in interpreting and clarifying historical developments in the area from the late 14th century until the present. The article analyses the spatial, geopolitical and geochronopolitical characteristics of the region, as well as the models of intercivilisational interaction between Europe and Eurasia. The author addresses the issue of the political identity of the region and its ability to play an independent role in the world politics.

  15. Balto-Chernomor'e v dvojnoj sisteme Evropa-Evrazija [The Baltic-Pontic region in the Europe-Eurasia dual system

    Directory of Open Access Journals (Sweden)

    Ilyin Mikhail

    2012-01-01

    Full Text Available This article considers the Baltic-Pontic Sea region not only as a geographical space of Intermarium (Międzymorze, Tarpjūris etc. but also as Intermundium or the interface of European and Russian (Eurasian civilization. The study sets out to clarify the logic of changing patterns shaping this geopolitical area. To this end, the concept of the Baltic-Pontic conflict system proposed by Vadim Tsymbursky is applied and further developed. In contrast to his agent-focused vehicle of analysis disclosing the power interactions in Intermarium, the authors advance an alternative structure-focused model of the Baltic-Pontic system (BPS as a multidimensional evolving space of heterogeneous interactions, which include cooperation. The authors suggest applying the BPS models in interpreting and clarifying historical developments in the area from the late 14th century until the present. The article analyses the spatial, geopolitical and geochronopolitical characteristics of the region, as well as the models of intercivilisational interaction between Europe and Eurasia. The author addresses the issue of the political identity of the region and its ability to play an independent role in the world politics.

  16. Bir destan kahramanı olarak Alpamış'ın sosyal statüsü

    OpenAIRE

    Çetin, Nagihan

    2016-01-01

    Bu makalede Vadim V. Trepavlov tarafından hazırlanmış olan “Yakut Destan Kahramanının Sosyal Statüsü” isimli makale esas alınarak Alpamış Destanının Kazak varyantı üzerinden Alpamış’ın sosyal statüsü belirlenmeye çalışılmıştır.Alpamış Destanı “Altay, Kazak, Karakalpak, Özbek, Başkurt Türkleri tarafından bilinen bir destandır. Bu destanın Türk kültüründeki önemini göstermesi bakımından yayılmış olduğu coğrafya önemlidir. Destanda epik Türk destanlarının pek çoğunda görülen çocuksuzluk ve bunun...

  17. Vth International Bulgarian Forum «Political and Ethno-Cultural Interaction between States and Peoples in the Post-Golden Horde Space (15th–16th centuries»

    Directory of Open Access Journals (Sweden)

    I.М. Mirgaleev

    2014-01-01

    Full Text Available This article contains a short report on the Vth International Bulgarian Forum under the name of “Political and Ethno-Cultural Interaction between States and Peoples in the Post-Golden Horde Space (15th–16th centuries”. The forum was held in the city of Yalta (the Crimea at the 6th–11th of November in 2013. Coordinators of the forum were Shigabutdin Marjani Institute of History of Academy of Sciences of the Republic of Tatarstan and the Crimean branch of Archaeology Institute of National academy of Sciences of the Ukraine. The Forum was attended by many well-known experts, whose reports have caused heated debate. The greatest interest was aroused by the following reports: Kradin Nicolay (Vladivostok, Russia. Medieval States of Eurasian Steppes: general and special; Trepavlov Vadim (Moscow, Russia. Institute of Beklyaribekship in the Socio-Political Structure of the Tatar Khanates; Vladimirov Georgi (Sofia, Bulgaria. Earrings in the Form of a Question Mark from Danubian Bulgaria (13th–14th centuries. Origin and area of distribution; Cherkas Boris (Kiev, Ukraine. Crimea and the Middle Dnieper Region in the Context of the Struggle in the Crimean Khanate in the 15th – the first third of the 16th centuries; Rusev Nikolay (Kishinev, Moldova. Tatars in Moldovan Charters of the 15th century; Izmailov Iskander (Kazan, Russia. Ethnocultural Interaction of the Kazan Khanate Population with Adjacent Territories; Ilnur Mirgaleev (Kazan, Russia. “Chingiz-name” of Utemish-Hadji as a Source for the History of the Turko-Tatar States; Matveev Andrey, Tataurov Sergey (Tomsk, Russia. History of Siberian Khanate: chronology and cartography; Brehunenko Viktor (Kiev, Ukraine. Kazak-Crimean Military-Political Alliances of the end of the 16th – middle of the 17th century.

  18. Glutathione peroxidase mimic ebselen improves glucose-stimulated insulin secretion in murine islets.

    Science.gov (United States)

    Wang, Xinhui; Yun, Jun-Won; Lei, Xin Gen

    2014-01-10

    Glutathione peroxidase (GPX) mimic ebselen and superoxide dismutase (SOD) mimic copper diisopropylsalicylate (CuDIPs) were used to rescue impaired glucose-stimulated insulin secretion (GSIS) in islets of GPX1 and(or) SOD1-knockout mice. Ebselen improved GSIS in islets of all four tested genotypes. The rescue in the GPX1 knockout resulted from a coordinated transcriptional regulation of four key GSIS regulators and was mediated by the peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α)-mediated signaling pathways. In contrast, CuDIPs improved GSIS only in the SOD1 knockout and suppressed gene expression of the PGC-1α pathway. Islets from the GPX1 and(or) SOD1 knockout mice provided metabolically controlled intracellular hydrogen peroxide (H2O2) and superoxide conditions for the present study to avoid confounding effects. Bioinformatics analyses of gene promoters and expression profiles guided the search for upstream signaling pathways to link the ebselen-initiated H2O2 scavenging to downstream key events of GSIS. The RNA interference was applied to prove PGC-1α as the main mediator for that link. Our study revealed a novel metabolic use and clinical potential of ebselen in rescuing GSIS in the GPX1-deficient islets and mice, along with distinct differences between the GPX and SOD mimics in this regard. These findings highlight the necessities and opportunities of discretional applications of various antioxidant enzyme mimics in treating insulin secretion disorders. REBOUND TRACK: This work was rejected during standard peer review and rescued by Rebound Peer Review (Antioxid Redox Signal 16: 293-296, 2012) with the following serving as open reviewers: Regina Brigelius-Flohe, Vadim Gladyshev, Dexing Hou, and Holger Steinbrenner.

  19. Gender-specific association of functional prodynorphin 68 bp repeats with cannabis exposure in an African American cohort

    Directory of Open Access Journals (Sweden)

    Yuferov V

    2018-04-01

    Full Text Available Vadim Yuferov,* Eduardo R Butelman,* Mary Jeanne Kreek Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY, USA *These authors contributed equally to this work Background: Cannabis use disorders (CUDs cause substantial neuropsychiatric morbidity and comorbidity. There is evidence for gender-based differences in CUDs, for instance, a greater prevalence in males than in females. The main active component of cannabis is delta 9-tetrahydrocannabinol (delta 9-THC, a partial agonist of the cannabinoid type 1 receptor. Preclinical studies show that genetic or pharmacological manipulation of the kappa opioid receptor/dynorphin system modulates the effects of delta 9-THC. Methods: In this case-control study of adult African Americans (n=476; 206 females, 270 males, we examined the association of the functional prodynorphin 68 bp (PDYN 68 bp promoter repeats with categorical diagnoses of cannabis dependence (Diagnostic and Statistical Manual of Mental Disorders-IV criteria, as well as with a rapid dimensional measure of maximum lifetime cannabis exposure (the Kreek–McHugh–Schluger–Kellogg cannabis scale. Results: The PDYN 68 bp genotype (examined as short–short [SS], short–long [SL], or long–long [LL], based on the number of repeats was not significantly associated with categorical cannabis-dependence diagnoses, either in males or in females. However, in males, the PDYN 68 bp SS+SL genotype was associated with both greater odds of any use of cannabis (p<0.05 and earlier age of first cannabis use, compared to the LL genotype (ie, 15 versus 16.5 years of age; p<0.045. Males in the SS+SL group also had greater odds of high lifetime exposure to cannabis, compared to the LL group (p<0.045. Of interest, none of the aforementioned genetic associations were significant in females. Conclusion: This study provides the first data on how the PDYN 68 bp genotype is associated with gender-specific patterns of

  20. The cytochrome P450 isoenzyme and some new opportunities for the prediction of negative drug interaction in vivo

    Directory of Open Access Journals (Sweden)

    Sychev DA

    2018-05-01

    Full Text Available Dmitrij A Sychev,1 Ghulam Md Ashraf,2 Andrey A Svistunov,3 Maksim L Maksimov,4 Vadim V Tarasov,3 Vladimir N Chubarev,3 Vitalij A Otdelenov,1 Natal’ja P Denisenko,1 George E Barreto,5,6 Gjumrakch Aliev7–9 1Russian Medical Academy of Postgraduate Education Studies, Moscow, Russia; 2King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia; 3Sechenov First Moscow State Medical University, Moscow, Russia; 4Branch Campus of the Federal State Budgetary Educational Institution of Further Professional Education «Russian Medical Academy of Continuous Professional Education» of the Ministry of Healthcare of the Russian Federation, Kazan State Medical Academy, Volga Region, Kazan, Russia; 5Departamento de Nutrición y Bioquímica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá D.C., Colombia; 6Instituto de Ciencias Biomédicas, Universidad Autónoma de Chile, Santiago, Chile; 7GALLY International Biomedical Research Consulting LLC, San Antonio, TX, USA; 8School of Health Science and Healthcare Administration, University of Atlanta, Johns Creek, GA, USA; 9Institute of Physiologically Active Compounds Russian Academy of Sciences, Chernogolovka, Russia Abstract: Cytochrome (CYP 450 isoenzymes are the basic enzymes involved in Phase I biotransformation. The most important role in biotransformation belongs to CYP3A4, CYP2D6, CYP2C9, CYP2C19 and CYP1A2. Inhibition and induction of CYP isoenzymes caused by drugs are important and clinically relevant pharmacokinetic mechanisms of drug interaction. Investigation of the activity of CYP isoenzymes by using phenotyping methods (such as the determination of the concentration of specific substrates and metabolites in biological fluids during drug administration provides the prediction of negative side effects caused by drug interaction. In clinical practice, the process of phenotyping of CYP isoenzymes and some endogenous substrates in the ratio of cortisol to 6

  1. Automated Management of Exercise Intervention at the Point of Care: Application of a Web-Based Leg Training System.

    Science.gov (United States)

    Dedov, Vadim N; Dedova, Irina V

    2015-11-23

    automatic email alerts sent upon achieving them. During 1-week training at home, automatic notifications were received on 4.4 days (SD 1.8). Although the high intensity interval training regimen was feasible on-site, it was difficult for self- and remote management. Opportunistic leg exercise under the desk, while working with a computer, and training in bed while viewing television were less intensive than dosed exercise bouts, but allowed prolonged leg mobilization of 73.7 minutes/day (SD 29.7). This study demonstrated the feasibility of self-control exercise training on-site, which was accompanied by online monitoring, electronic recording, personalization of exercise doses, and automatic reporting of adherence. The results suggest that this technology and its applications are useful for the delivery of Web-based exercise rehabilitation and cardiac training programs at the point of care. ©Vadim N Dedov, Irina V Dedova. Originally published in JMIR Rehabilitation and Assistive Technology (http://rehab.jmir.org), 23.11.2015.

  2. Assessment of chemical element migration in soil-plant complex of Urov endemic localities of East Transbaikalia

    Science.gov (United States)

    Vadim V., Ermakov; Valentina, Danilova; Sabsbakhor, Khushvakhtova; Aklexander, Degtyarev; Sergey, Tyutikov; Victor, Berezkin; Elena, Karpova

    2014-05-01

    - Salicaceae) and selenium (needles of larch - Larix sibirica L.) were found among the plants. References 1. Ermakov V., Jovanovic L. Characteristics of selenium migration in soil-plant system of East Meshchera and Transbaikalia// J. Geochem. Explor., 2010. Vol. 107, 200-205. 2. Ermakov Vadim, Jovanovic Larisa, Berezkin Victor, Tyutikov Sergey, Danilogorskaya Anastasiya, Danilova Valentina, Krechetova Elena, Degtyarev Alexander, Khushvakhtova Sabsbakhor. Chemical assessment of soil and water of Urov biogeochemical provinces of Eastern Transbaikalia// Ecologica, 2012. Vol. 19, 69, 5-9. 3. Ermakov V.V., Tuytikov S.F. Khushvakhtova S.D., Danilova V.N. Boev V.A., Barabanschikova R.N., Chudinova E.A. Peculiarities of quantitative determination of selenium in biological materials// Bulletin of the Tyumen State University Press, 2010, 3, 206-214. Supported by the Russian Foundation for Basic Research, grant number 12-05-00141a.

  3. Chandra Captures Venus In A Whole New Light

    Science.gov (United States)

    2001-11-01

    conducted the research. The Chandra observation of Venus was also a technological tour de force. The angular separation of Venus from the Sun, as seen from Earth, never exceeds 48 degrees. This relative proximity has prevented star trackers and cameras on other X-ray astronomy satellites from locking onto guide stars and pointing steadily in the direction of Venus to perform such an observation. Venus was observed on Jan. 10, 2001, with the Advanced CCD Imaging Spectrometer (ACIS) detector plus the Low Energy Transmission Grating and on Jan. 13, 2001, with the ACIS alone. Other members of the team were Vadim Burwitz and Jakob Engelhauser, Max Planck Institute; Carey Lisse, University of Maryland, College Park; and Scott Wolk, Harvard-Smithsonian Center for Astrophysics, Cambridge, Mass. These results were presented at this week's "New Visions of X-ray universe in the XMM-Newton and Chandra Era" symposium in Noordwijk, Netherlands. The Low Energy Transmission Grating was built by the Space Research Organization of the Netherlands and the Max Planck Institute, and the ACIS instrument was developed for NASA by The Pennsylvania State University, University Park, and the Massachusetts Institute of Technology (MIT), Cambridge. NASA's Marshall Space Flight Center in Huntsville, Ala., manages the Chandra program. The Smithsonian's Chandra X-ray Center controls science and flight operations from Cambridge, Mass.

  4. Bayesian approach to the assessment of the population-specific risk of inhibitors in hemophilia A patients: a case study

    Directory of Open Access Journals (Sweden)

    Cheng J

    2016-10-01

    Full Text Available Ji Cheng,1,2 Alfonso Iorio,2,3 Maura Marcucci,4 Vadim Romanov,5 Eleanor M Pullenayegum,6,7 John K Marshall,3,8 Lehana Thabane1,2 1Biostatistics Unit, St Joseph’s Healthcare Hamilton, 2Department of Clinical Epidemiology and Biostatistics, 3Department of Medicine, McMaster University, Hamilton, ON, Canada; 4Geriatrics, Fondazione Ca’ Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milan, Italy; 5Baxter HealthCare, Global Medical Affairs, Westlake Village, CA, USA; 6Child Health Evaluation Sciences, Hospital for Sick Children, 7Dalla Lana School of Public Health, University of Toronto, Toronto, 8Division of Gastroenterology, Hamilton Health Science, Hamilton, ON, Canada Background: Developing inhibitors is a rare event during the treatment of hemophilia A. The multifacets and uncertainty surrounding the development of inhibitors further complicate the process of estimating inhibitor rate from the limited data. Bayesian statistical modeling provides a useful tool in generating, enhancing, and exploring the evidence through incorporating all the available information.Methods: We built our Bayesian analysis using three study cases to estimate the inhibitor rates of patients with hemophilia A in three different scenarios: Case 1, a single cohort of previously treated patients (PTPs or previously untreated patients; Case 2, a meta-analysis of PTP cohorts; and Case 3, a previously unexplored patient population – patients with baseline low-titer inhibitor or history of inhibitor development. The data used in this study were extracted from three published ADVATE (antihemophilic factor [recombinant] is a product of Baxter for treating hemophilia A post-authorization surveillance studies. Noninformative and informative priors were applied to Bayesian standard (Case 1 or random-effects (Case 2 and Case 3 logistic models. Bayesian probabilities of satisfying three meaningful thresholds of the risk of developing a clinical

  5. Snowmaking in ski resorts: spatial decision support for management of snowpack

    Science.gov (United States)

    Loubier, Jean-Christophe; Kanevski, Mikhail; Doctor, Marut; Schumacher, Michael; Timonin, Vadim

    2010-05-01

    result is a map of probable heights provided to stakeholders, allowing them to adjust their production strategy based on the situation. Acknowledgements This work was partly supported by Swiss CTI project "Juste Neige". Bibliography SHARDUL Agrawala (ed)2007;Climate Change in the European Alps Adapting Winter Tourism and Natural Hazards Management; OECD Publishing Paris, France BADRE Michel, PRIME Jean-Louis, RIBIERE Georges 2009 ; Neige de culture : état des lieux et impacts environnementaux - Note socio-économique ; Conseil général de l'environnement et du développement durable ; Paris ; France DE JONG, Carmen., 2008. 'Resource conflicts in mountain: source and solutions'. Mountain Forum Bulletin 8:1,pp. 5-7. KANEVSKI Mikhail, POZDNOUKHOV Alexei, and TIMONIN Vadim (2009); Machine Learning for Spatial Environmental Data. Theory, Applications" Softwsare. EPFL and CRC Press.

  6. Pharmacodynamic genetic polymorphisms affect adverse drug reactions of haloperidol in patients with alcohol-use disorder

    Directory of Open Access Journals (Sweden)

    Zastrozhin MS

    2017-07-01

    Full Text Available Mikhail Sergeevich Zastrozhin,1,2 Vadim Markovich Brodyansky,3 Valentin Yurievich Skryabin,4 Elena Anatolievna Grishina,5 Dmitry Vladimirovich Ivashchenko,5 Kristina Anatolievna Ryzhikova,5 Ludmila Mikhaylovna Savchenko,1 Alexander Olegovich Kibitov,3 Evgeny Alekseevich Bryun,1,4 Dmitry Alekseevich Sychev6 1Department of Addictology, Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russia; 2Moscow Research and Practical Centre on Addictions of the Moscow Department of Healthcare, Center for the Prevention of Dependent Behavior, Moscow, Russia; 3Federal Medical Research Centre of Psychiatry and Addictology, Laboratory of Molecular Genetics, Moscow, Russia; 4Moscow Research and Practical Centre on Addictions of the Moscow Department of Healthcare, Department of Addictology, Moscow, Russia; 5Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Research Centre, Moscow, Russia; 6Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Department of Clinical Pharmacology and Therapy, Moscow, Russia Background: Antipsychotic action of haloperidol is due to blockade of D2 receptors in the mesolimbic dopamine pathway, while the adverse drug reactions are associated with striatal D2 receptor blockade. Contradictory data concerning the effects of genetic polymorphisms of genes encoding these receptors and associated structures (catechol-O-methyltransferase [COMT], glycine transporter and gene encoding the density of D2 receptors on the neuronal membrane are described.Objective: The objectives of this study were to evaluate the correlation between DRD2, SLC6A3 (DAT and COMT genetic polymorphisms and to investigate their effect on the development of adverse drug reactions in patients with alcohol-use disorder who received haloperidol.Patients and methods: The study

  7. EDITORIAL: Extreme Ultraviolet Light Sources for Semiconductor Manufacturing

    Science.gov (United States)

    Attwood, David

    2004-12-01

    issue of available EUV power from electrical discharge pinch plasmas and laser produced plasmas, including the roots of these requirements, the relevant plasma and radiation physics, and current state-of-the-art commercial technology. In the first paper of the cluster, Vadim Banine and Roel Moors of ASML in the Netherlands provide a detailed review of the required EUV power based on an economically viable throughput of one hundred 300 mm diameter wafers per hour, projected resist sensitivity, number of finite reflectivity multilayer coated surfaces and their collective spectral bandwidth, and a collection solid angle set by optical phase-space constraints and plasma source size. Thomas Krücken and his colleagues from Philips and the Fraunhofer Institute in Aachen present a theoretical model of radiation generation and transport based on model density and temperature profiles in an electrical discharge plasma, providing valuable insights into radiation physics and the limits to achievable power. Kenneth Fahy and his colleagues at UCD in Dublin and NIST in the US, in their paper, describe in detail atomic physics calculations of emission from relevant lines and unresolved transition arrays (UTAs) of candidate xenon and tin ions, each of which radiate strongly within the acceptance bandwidth of the multilayer coatings. The different elements, Xe and Sn, however, raise significantly different implications for source debris production and thus of requisite debris mitigation requirements. Björn Hannson and Hans Hertz of KTH University in Stockholm present a substantial review of laser produced plasmas for the EUV, including those based on liquid jet technologies, leading to a path of mass limited target material, and significant stand-off distance from the solid nozzle, which maximize EUV power generation while minimizing debris production. In addition to an extensive review of EUV source related literature, they describe experiments with laser irradiated droplets and

  8. Researchers Use NRAO Telescope to Study Formation Of Chemical Precursors to Life

    Science.gov (United States)

    2006-08-01

    discovered acetamide (CH3CONH2), which can be formed when a previously-discovered neutral molecule called formamide (HCONH2) combines with radicals such as CH2 and CH3, also previously discovered. Acetamide is particularly interesting because it contains a peptide bond which is the means for linking amino acids together to form proteins. Once interstellar molecules are ejected from dust grains into the gas phase, presumably by shock waves, they are free to rotate end-over-end. As gas molecules change their rotational modes, they can emit or absorb radiation at precise radio frequencies, called transitions, that are unique to each type of molecule. By detecting several rotational transitions, astronomers can unambiguously identify a specific interstellar molecule. "It is important to note that likely interstellar molecule candidates are first studied in gas-phase laboratory experiments so that transition frequencies are known in advance of an interstellar experiment," said Frank Lovas of the National Institute of Standards and Technology. Along the line of sight from the interstellar cloud to the telescope, thousands of billions of molecules undergo the exact same transition, producing a signal strong enough to be detected by sensitive equipment. For this type of work, the GBT is the world's most sensitive tool that can be accurately pointed and track astronomical objects. In addition to Hollis, Jewell, Remijan, and Lovas, the research team included Lewis Snyder of the University of Illinois; Harald Mollendal of the University of Oslo, Norway; Vadim Ilyushin of the Institute of Radio Astronomy of the National Academy of Sciences of the Ukraine; and Isabell Kleiner of the Universite Paris, France. The astronomers' reports on their results appeared in 8 separate editions of the Astrophysical Journal. The National Radio Astronomy Observatory is a facility of the National Science Foundation, operated under cooperative agreement by Associated Universities, Inc.

  9. Never Before Seen: Two Supermassive Black Holes in Same Galaxy

    Science.gov (United States)

    2002-11-01

    is a prime example of a massive galaxy in which stars are forming at an exceptionally rapid rate due to a recent collision and subsequent merger of two smaller galaxies. Because of the large amount of dust and gas in such galaxies, it is difficult to peer deep into their central regions with optical telescopes. However, X-rays emanating from the galactic core can penetrate the veil of gas and dust. NGC 6240 Optical & X-ray Comparison of NGC 6240 "The detection of a binary black hole supports the idea that black holes can grow to enormous masses in the centers of galaxies by merging with other black holes," said Komossa. "This is important for understanding how galaxies form and evolve," she said. Over the course of the next few hundred million years, the two black holes in NGC 6240, which are about 3000 light years apart, will drift toward one another and merge to form an even larger supermassive black hole. Toward the end of this process an enormous burst of gravitational waves will be produced several hundred million years from now. These gravitational waves will spread through the universe and produce ripples in the fabric of space, which would appear as minute changes in the distance between any two points. NASA's planned space-based detector, LISA (Laser Interferometer Space Antenna), will search for gravitational waves from massive black-hole mergers. These events are estimated to occur several times each year in the observable universe. "This is the first time we see a binary black hole in action, the smoking gun for something that will become a major gravitational wave burst in the future," said Hasinger. Chandra observed NGC 6240 for 10.3 hours with the Advanced CCD Imaging Spectrometer (ACIS). Other members of the team are Vadim Burwitz and Peter Predehl of the Max Planck Institute, Jelle Kaastra of the Space Research Organization Netherlands and Yasushi Ikebe of the University of Maryland in Baltimore. NASA's Marshall Space Flight Center in Huntsville, Ala

  10. III International Conference on Small Angle Neutron Scattering dedicated to the 80 anniversary of Yu.M. Ostanevich

    International Nuclear Information System (INIS)

    2017-01-01

    Preface “Among the many well-known fundamental and applied consequences of neutron discovery, one of the first was the emergence of structural neutron diffraction - one of the methods for studying the spatial structure of condensed matter at the atomic level. Investigating the dynamics of biological macromolecules by neutron diffraction methods is an area that is almost untouched. We believe that also in this direction one should expect rapid progress.” Yu.M.Ostanevich and I.N.Serdyuk Uspekhi Fizicheskih Nauk (1982) More than 30 years after Ostanevich and Serdyuk reviewed the then 50 years from the neutron discovery, we are happy to support their statement and prediction by reporting on the further progress in the field of neutron scattering research. Frank Laboratory of Neutron Physics has organized the III International Conference on Small Angle Neutron Scattering (YuMO2016) that was – not coincidently – dedicated to the 80th anniversary of Ostanevich. Yuriy Mechislavovich Ostanevich (1936–1992) has had a determinative and crucial contribution to the construction of spectrometers at the pulsed reactor IBR in Dubna, Russia. He contributed in particular to the development of time-of-flight small-angle neutron scattering (SANS) technique, and the selection of advanced scientific areas for its application. The SANS instrument at the IBR-2 reactor is called YuMO in his honour. The Ostanevich’s leadership and outstanding scientific achievements in SANS studies of polyelectrolytes, small molecules, fractals, metallic glasses, macromolecules, polymers, etc., were recognized also by a number of awards including the State Prize of the Russian Federation in 2000. To this end of course, we should not forget mentioning the contribution of close collaborators of Ostanevich: Laszlo Cser, Josef Plestil as well as Alexander Kunchenko, Vadim Bezzabotnov and Nikolay Gorski. The YuMO2016 conference focused on providing opportunities to discuss various possibilities of

  11. Obituary: Kenneth Ingvard Greisen, 1918-2007

    Science.gov (United States)

    Greisen, Eric W.

    2007-12-01

    him, he is widely quoted as saying ``My God, it worked!'' Following the war, Ken, along with Hans Bethe and other scientists, sent a letter to the President strongly advocating only non-military use of nuclear research. Ken and family returned to Cornell University and Ithaca, where he remained, except for sabbatical periods, for the rest of his life. He spent the next years studying cosmic rays and the showers of particles produced by them in the atmosphere and various absorbers. An array of scintillators atop Cornell buildings allowed both the direction and intensity of air showers to be determined. Detectors 600m underground, in a salt mine near Ithaca, detected only mesons with sufficient energy to penetrate so much material. In summers, detectors at a range of altitudes from the bottom to the top of Mount Evans (Colorado) provided altitudinal studies of cosmic-ray air showers and attracted an article in Life magazine. In early 1966, Ken realized that cosmic ray protons at energies above 6 x 1019 eV will interact significantly with the extremely low energy photons of the Cosmic Microwave Background, which had recently been discovered. If the sources of such extremely high-energy cosmic rays are at cosmological distances, this interaction should cause a sharp cutoff in the cosmic ray spectrum. The effect has been named the GZK cutoff after Greisen's paper and an independent, slightly later paper by Georgi Zatsepin and Vadim Kuzmin. Ken's paper also predicted a small dip in the cosmic-ray spectrum at energies of 1018-1020 eV, due to pair production by the thermal photons. Cosmic rays of such high energies cause the Earth's atmosphere to fluoresce, making the Earth itself into a detector. Beginning in the early 1960s, Ken and his group developed instruments to measure this fluorescence and implemented them, in a "fly's eye" configuration, in the hills surrounding Ithaca. The concept was taken around 1970 to the clearer skies of Utah, where a University of Utah group

  12. New Collective Monograph: The Golden Horde in World History (Kazan: Sh.Marjani Institute of History of AS RT, 2016. 968 p. + 28 p. of col. ins.

    Directory of Open Access Journals (Sweden)

    Marie Favereau-Doumenjou

    2016-12-01

    deeply influenced its surrounding world. This world included the successors states of the Mongol empire in China, Afghanistan, India, Persia and Anatolia as well as Byzantium, Russia, Europe and the Middle East. The density of the connections from the Mediterranean Sea to the Caspian Sea and as far as China illustrates how deeply the ulus of Jöchi was enmeshed with the wider world. Therefore, the history of the Golden Horde should not be disconnected from this world-shaping phenomenon. Nationalist historiographies are inclined to distort history, to create and disseminate self-serving clichés. The first task of historians is to avoid inaccurate terminology such as “the Tatar Yoke”, in order to encourage inquiries into more important questions: how to deal with the notion of a collective history when it crosses the borders of modern nations? What then are the role and the legacy of the Golden Horde in world history? The Golden Horde in World History gives some answers to these important questions. It achieves a twofold aim: to bring to a larger academic audience a cutting-edge research that remains barely known outside the circle of specialists and to integrate this research into the broader perspective of world history. It combines diverse approaches and questions not only to offer an exhaustive picture of the state of the field, but also to herald the most profitable directions of research and the most fruitful advances made. This comprehensive new synthesis is the result of the collaboration of leading scholars coming from major academic institutions: Sh.Marjani Institute of History of Tatarstan Academy of Sciences, Institute of Russian History of Russian Academy of Sciences and Oxford University. I wish to address my deepest thanks to those who turned a bold editorial project into this impressively compelling collective book: Rafael Khakimov, Ilnur Mirgaleev, Roman Hautala, Vadim Trepavlov. Thanks to the fantastic energy of our colleagues from the Sh

  13. EDITORIAL: Focus on Quantum Cryptography: Theory and Practice FOCUS ON QUANTUM CRYPTOGRAPHY: THEORY AND PRACTICE

    Science.gov (United States)

    Lütkenhaus, N.; Shields, A. J.

    2009-04-01

    distribution network in Vienna M Peev, C Pacher, R Alléaume, C Barreiro, J Bouda, W Boxleitner, T Debuisschert, E Diamanti, M Dianati, J F Dynes, S Fasel, S Fossier, M Fürst, J-D Gautier, O Gay, N Gisin, P Grangier, A Happe, Y Hasani, M Hentschel, H Hübel, G Humer, T Länger, M Legré, R Lieger, J Lodewyck, T Lorünser, N Lütkenhaus, A Marhold, T Matyus, O Maurhart, L Monat, S Nauerth, J-B Page, A Poppe, E Querasser, G Ribordy, S Robyr, L Salvail, A W Sharpe, A J Shields, D Stucki, M Suda, C Tamas, T Themel, R T Thew, Y Thoma, A Treiber, P Trinkler, R Tualle-Brouri, F Vannel, N Walenta, H Weier, H Weinfurter, I Wimberger, Z L Yuan, H Zbinden and A Zeilinger Stable quantum key distribution with active polarization control based on time-division multiplexing J Chen, G Wu, L Xu, X Gu, E Wu and H Zeng Controlling passively quenched single photon detectors by bright light Vadim Makarov Information leakage via side channels in freespace BB84 quantum cryptography Sebastian Nauerth, Martin Fürst, Tobias Schmitt-Manderbach, Henning Weier and Harald Weinfurter Standardization of quantum key distribution and the ETSI standardization initiative ISG-QKD Thomas Länger and Gaby Lenhart Entangled quantum key distribution with a biased basis choice Chris Erven, Xiongfeng Ma, Raymond Laflamme and Gregor Weihs Finite-key analysis for practical implementations of quantum key distribution Raymond Y Q Cai and Valerio Scarani Field test of a continuous-variable quantum key distribution prototype S Fossier, E Diamanti, T Debuisschert, A Villing, R Tualle-Brouri and P Grangier Physics and application of photon number resolving detectors based on superconducting parallel nanowires F Marsili, D Bitauld, A Gaggero, S Jahanmirinejad, R Leoni, F Mattioli and A Fiore Device-independent quantum key distribution secure against collective attacks Stefano Pironio, Antonio Acín, Nicolas Brunner, Nicolas Gisin, Serge Massar and Valerio Scarani 1310 nm differential-phase-shift QKD system using