KGB killer plaanis Savisaare mõrva / Tarmo Vahter

Index Scriptorium Estoniae

Vahter, Tarmo, 1970-

2008-01-01

Autor analüüsib dokumente, mille kohaselt vahistas Eriteenistus 1991. aasta augustis Andrei Stekolshtshikovi, kelle väidetavaks ülesandeks oli tappa peaminister Edgar Savisaar. Vt. samas: 17 aastat hiljem: mis neist on saanud?

Aasta kõige ägedama loodusfoto tegi Remo Savisaar

Index Scriptorium Estoniae

2011-01-01

Ajakirja "Eesti Loodus" 2011. a. fotovõistlusest, tutvustab ajakirja peatoimetaja Toomas Kukk. Loomafotode üldarvestuse peaauhind - Remo Savisaar. Taimefotode peaauhind - Sven Začek, noorte arvestuses Karl Kaisel. Seenefotode peaauhind - Jan Lepamaa

Minister Savisaar appoints advisor, weighs ferry link, sell-offs

Index Scriptorium Estoniae

2005-01-01

Majandus- ja kommunikatsiooniministeeriumi nõunikuks saanud ärimees Oleg Harlamov tekitab probleeme, kuna omab aktsiaid suhtekorraldusfirmas, mis konsulteerib raudtee-ettevõtet Spacecom. Majandus- ja kommunikatsiooniminister Edgar Savisaare sõnul võib riik müüa oma Esonian Airways'i aktsiad.

Edgar Savisaar murdus eile õhtul / Kadri Jakobson, Aivar Hundimägi

Index Scriptorium Estoniae

Jakobson, Kadri, 1970-

2010-01-01

Moskvast saabunud Deniss Boroditšit, rahastamisskandaali ühte võtmetegelast, võtsid Tallinna lennujaamas vastu Keskerakonna esimees Edgar Savisaar ja Kalle Klandorf, kes viisid abilinnapea tõenäoliselt selgitusi andma

Aktuaalne intervjuu Keskerakonna esimehe Edgar Savisaarega / Edgar Savisaar ; interv. Heimar Lenk

Index Scriptorium Estoniae

Savisaar, Edgar, 1950-

2002-01-01

Keskerakonna juht Edgar Savisaar peab kõige tähtsamaks töörahu ja asjalikku tööõhkkonda praeguses koalitsioonis. Reformierakonna esimehe ja peaminister Siim Kallase intervjuust SL Õhtulehele ja presidentaalse vabariigi ideest. Autor: Keskerakond

Palgareform peatab võlakriisi tekke / Edgar Savisaar

Index Scriptorium Estoniae

Savisaar, Edgar, 1950-

2007-01-01

Ilmunud ka: Severnoje Poberezhje, 6. jaan. 2007, lk. 2; Meie Maa, 8. jaan. 2007, lk. 2; Oma Saar, 9. jaan. 2007, lk. 5; Nädaline, 9. jaan. 2007, lk. 4; Hiiu Leht, 9. jaan. 2007, lk. 2; Sakala, 9. jaan. 2007, lk. 2; Lääne Elu, 11. jaan. 2007, lk. 2. Majandusminister Edgar Savisaare sõnul saavad tänapäeva laenutarbimise ja tõusvate hindade majanduses sisemise enesekindluse anda vaid palgareformist tulenevad jätkusuutlikult tõusvad sissetulekud

Savisaar kustutas Tallinki 30 miljoni kroonise võla riigile / Peeter Raidla

Index Scriptorium Estoniae

Raidla, Peeter, 1955-

2005-01-01

Ilmunud ka: Delovõje Vedomosti 22. juuni lk. 4. Majandus- ja kommunikatsiooniminister Edgar Savisaar võttis vastu käskkirja, millega tunnistas lootusetuks veeteede ameti nõuded AS-idele Tallink Grupp ja Hansatee Cargo tuletorni- ja jäämurdmistasude võlgnevuse osas. Vt. samas intervjuud veeteede ameti peadirektori Andrus Maidega

Savisaar : Vene suurfirma ei esindanud Eesti huve / Jaanus Piirsalu

Index Scriptorium Estoniae

Piirsalu, Jaanus, 1973-

2006-01-01

Majandus- ja kommunikatsiooniminister Edgar Savisaar lükkab ümber BRS-i omaniku Edward Burkhardti väited ning teatab, et Severstaltransi üks juhte Andrei Filatov esindas kohtumisel Eesti Raudtee omaniku E. Burkhardtiga ainult oma firma ärihuve, kui ta soovitas müüa raudtee Eesti riigile. Minister peab võimalikuks, et BRS-il oli algusest peale kavas müüa raudtee Vene firmadele. Lisa: Severstaltransi soovitus

Hundisilma Edgar, parajalt paks ja parimais aastais / Edgar Savisaar ; interv. Kaire-Külli Kuldbek

Index Scriptorium Estoniae

Savisaar, Edgar, 1950-

2006-01-01

Eesti Keskerakonna esimees, majandus- ja kommunikatsiooniminister Edgar Savisaar iseloomustab Vilja Savisaart abikaasa ja poliitikuna ning vastab küsimustele, mis puudutavad tema sidemeid usuga, pereelu ning võimalikku kandideerimist presidendiks

Laidoneri-Savisaare villa hinnati juba 2003. aastal 800 000 kroonile / Martti Kass

Index Scriptorium Estoniae

Kass, Martti

2005-01-01

Edgar Savisaare firma ostetud suvila Keila-Joal oli 2003. aastal Arco Vara hinnangul väärt 800 000 krooni. Kinnisvaraekspertide hinnangul on Keila-Joa kinnisvara väärtus viimaste aastatega mitu korda suurenenud. Lisa: Ojulandi ja Käo maja hinnati 3,25 miljonile

Aeg on otsustada : Rail Baltica : rahvusvaheline raudtee toob Eestile kasu / Vilja Savisaar-Toomast

Index Scriptorium Estoniae

Savisaar-Toomast, Vilja, 1962-

2011-01-01

Vilja Savisaar-Toomast on kindel, et Rail Baltica projekt tuleb esitada Euroopa Liidu finantsperioodiks 2014-2020 ning eelistab marsruuti Tallinn-Pärnu-Riia-Kaunas. Tõenäoliselt on võimalik saada projektile Euroopa Liidult ka maksimumtoetus ehk määraga 60-70%

Opposition parties' letter to the Ambassador of the U.S., Tallinn, July 20, 2000 / Edgar Savisaar

Index Scriptorium Estoniae

Savisaar, Edgar, 1950-

2000-01-01

Opositsiooniparteide pöördumine Ameerika suursaadiku poole Narva Elektrijaamade eratamise küsimuses: elektrijaamade erastamine NRG Energy'le praegustel tingimustel ei vasta rahvuslikele huvidele. Alla kirjutanud: Edgar Savisaar, Villu Reiljan, Viktor Andrejev, Aldo Vinkel

Miks on Savisaar ja proua Bush Birma kallal / Mai Loog

Index Scriptorium Estoniae

Loog, Mai, 1960-

2007-01-01

Ilmunud ka: Postimees : na russkom jazõke 29. mai lk. 7. Birma sõjaväeline valitsus otsustas taas pikendada aasta võrra Nobeli rahupreemia laureaadi ja demokraatliku opositsiooni liidri Aung San Suu Kyi 11-aastast koduaresti, mille vastu astusid välja USA senaatorid presidendiproua Laura Bushi juhtimisel kui ka Tallinna linnapea Edgar Savisaar koos Pariisi ja Rooma linnapeadega. Birma hunta plaanitavast konstitutsioonist, kus aatomienergia on pandud riigikaitse ja julgeoleku alla. Venemaa aatomienergia agentuuri Rosatomi lepingust Birma huntaga aatomienergia tootmiseks

Specificity determinants in the interaction of apolipoprotein(a) kringles with tetranectin and LDL.

Science.gov (United States)

Caterer, Nigel R; Graversen, Jonas H; Jacobsen, Christian; Moestrup, Søren K; Sigurskjold, Bent W; Etzerodt, Michael; Thøgersen, Hans C

2002-11-01

Lipoprotein(a) is composed of low density lipoprotein and apolipoprotein(a). Apolipoprotein(a) has evolved from plasminogen and contains 10 different plasminogen kringle 4 homologous domains [KIV(1-110)]. Previous studies indicated that lipoprotein(a) non-covalently binds the N-terminal region of lipoprotein B100 and the plasminogen kringle 4 binding plasma protein tetranectin. In this study recombinant KIV(2), KIV(7) and KIV(10) derived from apolipoprotein(a) were produced in E. coli and the binding to tetranectin and low density lipoprotein was examined. Only KIV(10) bound to tetranectin and binding was similar to that of plasminogen kringle 4 to tetranectin. Only KIV(7) bound to LDL. In order to identify the residues responsible for the difference in specificity between KIV(7) and KIV(10), a number of surface-exposed residues located around the lysine binding clefts were exchanged. Ligand binding analysis of these derivatives showed that Y62, and to a minor extent W32 and E56, of KIV(7) are important for LDL binding to KIV(7), whereas R32 and D56 of KIV(10) are required for tetranectin binding of KIV(10).

Koalitsioon ei plaani linna juhtimises muudatusi / Ester Vilgats, Eno-Gerrit Link

Index Scriptorium Estoniae

Vilgats, Ester

2008-01-01

Pärnu koalitsiooninõukogu sõnul pole põhjust linnapea Mart Viisitamme, abilinnapea Simmo Saare ja koalitsiooninõukogu esimehe Vello Järvesalu välja vahetamiseks, kuna kedagi pole süüdi mõistetud

[Marie Heiberg. Üks naine kurbade silmadega] / Marko Mägi

Index Scriptorium Estoniae

Mägi, Marko

2010-01-01

Arvustus: Heiberg, Marie. Üks naine kurbade silmadega : Eesti luuletaja Marie Heibergi õnne ja valu, rõõmu ja mure lugu kirjades / [koostajad Iivi Lepik, Kirsten Simmo]. Tallinn : Eesti Teatri- ja Muusikamuuseum : SE & JS, 2010

Apolipoprotein(a) Kringle-IV Type 2 Copy Number Variation Is Associated with Venous Thromboembolism

DEFF Research Database (Denmark)

Sticchi, Elena; Magi, Alberto; Kamstrup, Pia R

2016-01-01

(a), including the kringle-IV type 2 (KIV-2) size polymorphism. Aim of the study was to investigate the role of LPA gene KIV-2 size polymorphism and single nucleotide polymorphisms (SNPs) (rs1853021, rs1800769, rs3798220, rs10455872) in modulating VTE susceptibility. Five hundred and sixteen patients with VTE...... without hereditary and acquired thrombophilia and 1117 healthy control subjects, comparable for age and sex, were investigated. LPA KIV-2 polymorphism, rs3798220 and rs10455872 SNPs were genotyped by TaqMan technology. Concerning rs1853021 and rs1800769 SNPs, PCR-RFLP assay was used. LPA KIV-2 repeat...

Pikaro: hull, kui Pärnu jätkab samade juhtoinastega / Tuuli Koch

Index Scriptorium Estoniae

Koch, Tuuli

2008-01-01

Kaitsepolitsei asub üle kuulama Pärnu linnapead Mart Viisitamme ja abilinnapead Simmo Saart, keda kahtlustatakse riigihangetes omade soosimises, samal ajal arutlevad kriisi sattunud linna volikogu liikmed selle üle, kuidas linnajuhtimisega antud olukorras edasi minna. Vt. samas: Pärnu linnavalitsus; Pärnu linnavolikogu

Süüdistus: Pärnu meer Viisitamm sai altkäemaksu / Erik Müürsepp, Erik Rand

Index Scriptorium Estoniae

Müürsepp, Ene, 1962-

2009-01-01

Lääne ringkonnaprokuratuur süüdistab Pärnu linnapead Mart Viisitamme ja abilinnapead Simmo Saart saladuse hoidmise kohustuse rikkumises ja usalduse kuritarvitamises. Linnapead süüdistatakse samuti ka altkäemaksu võtmises Tänavapuhastuse AS-ilt. Vt. samas: Lutikatõrje ei aidanud

Valitsus kehtestab range rahadistsipliini / Argo Ideon

Index Scriptorium Estoniae

Ideon, Argo, 1966-

2000-01-01

Eelarvestrateegia üldeesmärgid 2001-2004. Kommenteerivad Kalle Jürgenson, Marju Lauristin, Edgar Savisaar. Parlamendisaadik (K. Jürgenson, M. Lauristin, E. Savisaar). Ilmunud ka: Estonija 15. mai lk. 8

Tallinn - eto nash s vami gorod / Leivi Sher

Index Scriptorium Estoniae

Šer, Leivi, 1941-

2007-01-01

Linnavolikogu valis 5. aprillil Tallinna linnapeaks Keskerakonna esimehe Edgar Savisaare. Rääkides ees ootavatest ülesannetest, loetles E. Savisaar ئ Vabaduse väljaku uuendamine, Kopli liinid, Pae park

Poliitiline trips-traps-trull / Eiki Nestor

Index Scriptorium Estoniae

Nestor, Eiki, 1953-

2002-01-01

Rahvaerakond Mõõdukad aseesimees Eiki Nestor kommenteerib Keskerakonna juhi Edgar Savisaare tegevust pärast peaminister Mart Laari tagasiastumist ning Edgar Savisaare läkitust Rahvaerakonnale Mõõdukad. Autor: Rahvaerakond Mõõdukad

Apolipoprotein(a Kringle-IV Type 2 Copy Number Variation Is Associated with Venous Thromboembolism.

Directory of Open Access Journals (Sweden)

Elena Sticchi

Full Text Available In addition to the established association between high lipoprotein(a [Lp(a] concentrations and coronary artery disease, an association between Lp(a and venous thromboembolism (VTE has also been described. Lp(a is controlled by genetic variants in LPA gene, coding for apolipoprotein(a, including the kringle-IV type 2 (KIV-2 size polymorphism. Aim of the study was to investigate the role of LPA gene KIV-2 size polymorphism and single nucleotide polymorphisms (SNPs (rs1853021, rs1800769, rs3798220, rs10455872 in modulating VTE susceptibility. Five hundred and sixteen patients with VTE without hereditary and acquired thrombophilia and 1117 healthy control subjects, comparable for age and sex, were investigated. LPA KIV-2 polymorphism, rs3798220 and rs10455872 SNPs were genotyped by TaqMan technology. Concerning rs1853021 and rs1800769 SNPs, PCR-RFLP assay was used. LPA KIV-2 repeat number was significantly lower in patients than in controls [median (interquartile range 11(6-17 vs 15(9-25, p<0.0001]. A significantly higher prevalence of KIV-2 repeat number ≤7 was observed in patients than in controls (33.5% vs 15.5%, p<0.0001. KIV-2 repeat number was independently associated with VTE (p = 4.36 x10-9, as evidenced by the general linear model analysis adjusted for transient risk factors. No significant difference in allele frequency for all SNPs investigated was observed. Haplotype analysis showed that LPA haplotypes rather than individual SNPs influenced disease susceptibility. Receiver operating characteristic curves analysis showed that a combined risk prediction model, including KIV-2 size polymorphism and clinical variables, had a higher performance in identifying subjects at VTE risk than a clinical-only model, also separately in men and women.

Okk hakkas NRG-tehingu pooldajaks / Gunnar Okk ; interv. Argo Ideon

Index Scriptorium Estoniae

Okk, Gunnar, 1960-

2001-01-01

Eesti Energia juhatuse esimees on kindel, et Narva elektrijaamade müügi lõplikud lepingud sõlmitakse veel tänavu. Arvamust avaldavad: Lennart Meri, Melissa Wells, Mart Laar ja Edgar Savisaar. Parlamendisaadik (E. Savisaar)

9-tolline rannamortiir M1877. Ühe Narva Hermanni kindluse läänehoovis seisva suurtüki lugu / Ilja Davõdov

Index Scriptorium Estoniae

Davõdov, Ilja

2016-01-01

Mortiiri loomisloost. Mortiiride kasutamisest lahingutes. Peeter Suure merekindlusest. Tallinna maarinde suurtükiväest. Mortiiridest 1918-1920. aastate sõjasündmustes. Suurtükiväest Narva kaitseliinil. 229-mm rannamortiiridest Teises maailmasõjas. Mortiiripatareidest pärast Teist maailmasõda

Pärnu linnavalitsuse hinnang esimesele valitsemisaastale / Eno-Gerrit Link

Index Scriptorium Estoniae

Link, Eno-Gerrit

2006-01-01

Ajaleht esitas Pärnu linnajuhtidele kolm küsimust. Vastasid linnapea Mart Viisitamm, abilinnapea majanduse valdkonnas Raul Sarandi, abilinnapea arengu ja planeerimise valdkonnas Mart Alliku, abilinnapea kultuuri, spordi ja sotsiaalvaldkonnas Margus Tammekivi ja linnavalitsuse liige turvalisuse valdkonnas Simmo Saar. Arvamust avaldavad Reformierakonna Pärnu piirkonna esimees Väino Hallik ja SDE esindaja Pärnu linnavolikogus Valter Parve

President Ilves tegi majandusalase pöördumise

Index Scriptorium Estoniae

2008-01-01

President Toomas Hendrik Ilves postitas populaarsesse videoportaali Youtube läkituse, milles avaldas arvamust, et praegustes majandushädades peaksid vastutuse võtma kõik 2003. aastast Eestit valitsenud erakonnad. Arvamust avaldavad: parlamendiliikmed Tarmo Mänd (ERL), Vilja Savisaar (Keskerakond) ja Keskerakonna esimees Edgar Savisaar

Karolinska Interpersonal Violence Scale predicts suicide in suicide attempters.

Science.gov (United States)

Jokinen, Jussi; Forslund, Kaj; Ahnemark, Ewa; Gustavsson, J Petter; Nordström, Peter; Asberg, Marie

2010-08-01

Both childhood trauma and violent behavior are important risk factors for suicidal behavior. The aim of the present study was to construct and validate a clinical rating scale that could measure both the exposure to and the expression of violence in childhood and during adult life and to study the ability of the Karolinska Interpersonal Violence Scale (KIVS) to predict ultimate suicide in suicide attempters. A total of 161 suicide attempters and 95 healthy volunteers were assessed with the KIVS measuring exposure to violence and expressed violent behavior in childhood (between 6-14 years of age) and during adult life (15 years or older). The Buss-Durkee Hostility Inventory (BDHI), "Urge to act out hostility" subscale from the Hostility and Direction of Hostility Questionnaire (HDHQ), and the Early Experience Questionnaire (EEQ) were used for validation. All patients were followed up for cause of death and a minimum of 4 years from entering in the study. Five patients who committed suicide within 4 years had significantly higher scores in exposure to violence as a child, in expressed violent behavior as an adult, and in KIVS total score compared to survivors. Suicide attempters scored significantly higher compared to healthy volunteers in 3 of the 4 KIVS subscales. There were significant correlations between the subscales measuring exposure to and expression of violent behavior during the life cycle. BDHI, Urge to act out hostility, and EEQ validated the KIVS. Exposure to violence in childhood and violent behavior in adulthood are risk factors for completed suicide in suicide attempters. Behavioral dysregulation of aggression is important to assess in clinical work. The KIVS is a valuable new tool for case detection and long-term clinical suicide prevention. Copyright 2010 Physicians Postgraduate Press, Inc.

Eestlaste imepäraselt vahelduvad vaimustuse vood / Herbert Vainu

Index Scriptorium Estoniae

Vainu, Herbert, 1929-2011

2004-01-01

Autor kommenteerib Eesti poliitilist olukorda alates Edgar Savisaare poolt algatatud IMEst ja Rahvarindest, Keskerakonna ja Savisaare valitsuse tegevust, kritiseerib samas järgmisi valitsusjuhte. Kommentaar Arnold Rüütli presidendiks ja Res Publica võimule saamisele, sotsiaaldemokraatide võidule europarlamendi valimistel ning üüripiirmäärade kaotamise seaduse läbisurumisele Riigikogus

Poliitikute soodsad majaostud jätavad jõuministrid külmaks / Tuuli Koch, Priit Rajalo

Index Scriptorium Estoniae

Koch, Tuuli

2005-01-01

Peaminister Andrus Ansipi ja justiitsministri Rein Langi suhtumisest majandusminister Edgar Savisaare Keila-Joa krundi ostusse. 500 000 krooni eest ostis kinnistu Keila-Joal ka ärimees Raimo Kägule kuuluv firma OÜ Marriot. Lisa: Savisaare küsitavad tehingud. Vt. samas: Politseimaja rent toob Oliver Kruudale miljoneid. Kommenteerib ASi Kalev Real Estate Company nõukogu liige Oliver Kruuda

Combining the Suicide Intent Scale and the Karolinska Interpersonal Violence Scale in suicide risk assessments.

Science.gov (United States)

Stefansson, J; Nordström, P; Runeson, B; Åsberg, M; Jokinen, J

2015-09-23

High suicide intent, childhood trauma, and violent behavior are risk factors for suicide in suicide attempters. The aim of this study was to investigate whether the combined assessment of suicide intent and interpersonal violence would provide a better prediction of suicide risk than an assessment of only suicide intent or interpersonal violence. This is a cohort study involving 81 suicide attempters included in the study between 1993 and 1998. Patients were assessed with both the Suicide Intent Scale (SIS) and the Karolinska Interpersonal Violence Scale (KIVS). Through the unique personal identification number in Sweden, patients were linked to the Cause of Death Register maintained by the Swedish National Board of Health and Welfare. Suicides were ascertained from the death certificates. Seven of 14 patients who had died before April 2013 had committed suicide. The positive predictive value for the Suicide Intent Scale alone was 16.7 %, with a specificity of 52 % and an area under the curve of 0.74. A combined assessment with the KIVS gave higher specificity (63 %) and a positive predictive value of 18.8 % with an AUC of 0.83. Combined use of SIS and KIVS expressed interpersonal violence as an adult subscale gave a sensitivity of 83.3 %, a specificity of 80.3 %, and a positive predictive value of 26 % with an AUC of 0.85. The correlation between KIVS and SIS scores was not significant. Using both the the SIS and the KIVS combined may be better for predicting completed suicide than using them separately. The nonsignificant correlation between the scales indicates that they measure different components of suicide risk.

The Potency of Bixa orellana Seedcouts Extract’s as Antiimflamation Drug

Directory of Open Access Journals (Sweden)

Atina Hussaana

2012-12-01

Design and Method: This study was post test only control group design. Twenty four mice is selected randomly then divided into four groups, KI (extract 0.09 mg, K.II (extract 0.18 mg dose, K.III (aspirin 90 mg, and K.IV (CMCNa 0.125%. Oedema volume was measured before injection karagenin 1%, two, 2.5, three and four hours after injection karagenin. The mean reduction in inflammation were tested by one way anova and pos hoc LSD. Result: Greatest reduction in inflammation indicated by K.III (0.100 ml, then in K.II (0.067 ml, KI (0.072 ml, and lowest in K.IV (-0.017 ml. Differences in the reduction of inflammation significantly different between KI and K.II K.IV; and K.III whereas no significant difference was found between KI and K.III K.II. Conclusion: The extract of the outer seed coats of annatto (Bixa orellana L. have antiimflamantory activity in mice that was induced by karagenin 1% (Sains Medika, 4(2:134-141.

Standard test method for plane-strain (Chevron-Notch) fracture toughness of metallic materials

CERN Document Server

American Society for Testing and Materials. Philadelphia

1997-01-01

1.1 This test method covers the determination of plane-strain (chevron-notch) fracture toughnesses, KIv or KIvM, of metallic materials. Fracture toughness by this method is relative to a slowly advancing steady state crack initiated at a chevron-shaped notch, and propagating in a chevron-shaped ligament (Fig. 1). Some metallic materials, when tested by this method, exhibit a sporadic crack growth in which the crack front remains nearly stationary until a critical load is reached. The crack then becomes unstable and suddenly advances at high speed to the next arrest point. For these materials, this test method covers the determination of the plane-strain fracture toughness, KIvj or KIvM, relative to the crack at the points of instability. Note 1—One difference between this test method and Test Method E 399 (which measures KIc) is that Test Method E 399 centers attention on the start of crack extension from a fatigue precrack. This test method makes use of either a steady state slowly propagating crack, or a...

Antidepressive and BDNF effects of enriched environment treatment across ages in mice lacking BDNF expression through promoter IV

Science.gov (United States)

Jha, S; Dong, B E; Xue, Y; Delotterie, D F; Vail, M G; Sakata, K

2016-01-01

Reduced promoter IV-driven expression of brain-derived neurotrophic factor (BDNF) is implicated in stress and major depression. We previously reported that defective promoter IV (KIV) caused depression-like behavior in young adult mice, which was reversed more effectively by enriched environment treatment (EET) than antidepressants. The effects of promoter IV-BDNF deficiency and EET over the life stages remain unknown. Since early-life development (ED) involves dynamic epigenetic processes, we hypothesized that EET during ED would provide maximum antidepressive effects that would persist later in life due to enhanced, long-lasting BDNF induction. We tested this hypothesis by determining EET effects across three life stages: ED (0–2 months), young adult (2–4 months), and old adult (12–14 months). KIV mice at all life stages showed depression-like behavior in the open-field and tail-suspension tests compared with wild-type mice. Two months of EET reduced depression-like behavior in ED and young adult, but not old adult mice, with the largest effect in ED KIV mice. This effect lasted for 1 month after discontinuance of EET only in ED mice. BDNF protein induction by EET in the hippocampus and frontal cortex was also the largest in ED mice and persisted only in the hippocampus of ED KIV mice after discontinuance of EET. No gender-specific effects were observed. The results suggest that defective promoter IV causes depression-like behavior, regardless of age and gender, and that EET during ED is particularly beneficial to individuals with promoter IV-BDNF deficiency, while additional treatment may be needed for older adults. PMID:27648918

Presidendi paljurääkiv vaikimine / Vello Helk

Index Scriptorium Estoniae

Helk, Vello, 1923-2014

2005-01-01

Artikli autori arvates ei ole Eesti riigikaitse seisukohalt õige, et president Arnold Rüütel ei soovi avalikustada Boris Jeltsini poolt augustiputshi ajal avaldatud Eesti jaoks planeeritud nukuvalitsuse juhti. Ilmunud ka Eesti Päevaleht = Estniska Dagbladet, 2005/Sep/15, lk. 4

Euroopa parlamenti kandideerijad lubavad kaitsta väikese Eesti huve / Matis Song

Index Scriptorium Estoniae

Song, Matis, 1978-

2004-01-01

11. mail 2004 Rapla maavalitsuse haldushoones toimunud kohtumisest Euroopa Parlamendi saadikukandidaatide Tunne Kelami, Tiit Tammsaare, Toomas Savi, Vilja Savisaare, Mart Viisitamme ja Urmas Reinsaluga

Jüri Pihl usub, et sotsid suudavad Tallinna juhtimist muuta / Urmas Seaver ; kommenteerinud Remo Holsmer ja Indrek Raudne

Index Scriptorium Estoniae

Seaver, Urmas, 1973-

2009-01-01

Sotsiaaldemokraatide juht Jüri Pihl ja Keskerakonna liider Edgar Savisaar allkirjastasid Tallinna juhtimise koalitsioonileppe. Vt. samas: Mõned olulisemad lubadused koalitsioonileppest Tallinna juhtimiseks 2009-2013

Suursaadikud Keskerakonna peakorteris

Index Scriptorium Estoniae

2001-01-01

Ameerika Ühendriikide suursaadik Melissa Wells kohtus Edgar Savisaare, Peeter Kreitzbergi ja Sven Mikseriga. Kommentaarid suursaadik Melissa Wells'ilt. Suurbritannia suursaadik Sarah Squire Keskerakonna peakorteris

The Center Party - political games like never before / Kristiina Raudsepp

Index Scriptorium Estoniae

Raudsepp, Karoliina

2011-01-01

Keskerakonna meediakajastusi tõstnud ettevõtmised nagu Indrek Tarandi seadmine teiseks presidendikandidaadiks ja Jüri Ratase osalemine Keskerakonna juhi valimistel tõestavad Edgar Savisaare tugevust poliitmaastikul

Kuidas kaasajal mõtestada rahvuslust? / ref. Urmi Reinde

Index Scriptorium Estoniae

2008-01-01

Keskerakonna noortekogu korraldatud konverentsil "Kuidas kaasajal mõtestada rahvuslust?" peetud ettekannete refereeringud: Edgar Savisaar, Leif Kalev, Ahto Lobjakas, Indrek Neivelt, Iris Pettai, Andrei Hvostov, Rein Ruutsoo

Hovõi narvskii most na podhode

Index Scriptorium Estoniae

2006-01-01

Majandus- ja kommunikatsiooniminister Edgar Savisaar ning Vene Föderatsiooni transpordiminister Igor Levitin allkirjastasid 2006. a. juuli lõpus kavatsuste protokolli Narva jõele uue silla ehitamise kohta

Kto uspel, tot i sel / Jekaterina Rodina

Index Scriptorium Estoniae

Rodina, Jekaterina

2005-01-01

Autori arvates on Tallinna linnavalitsuses kujunenud unikaalne situatsioon, kus linnapea toolil istuvad kaks inimest - nominaalselt endine abilinnapea Jüri Ratas, kulisside taga majandus- ja kommunikatsiooniminister Edgar Savisaar

Nostalgia Pühajärve kaldal / Paavo Kangur

Index Scriptorium Estoniae

Kangur, Paavo, 1966-

2006-01-01

Edgar Savisaare kunagise üleminekuvalitsuse ministrite kohtumisest Pühajärvel. Vt. samas: Eksriigiministri Raivo Vare toost; Eksmajandusministri Jaak Leimanni anekdoot naistest; Eksharidusminister Rein Loik arvab. Fotod

Unustamatu aasta 1988 / ref. Urmi Reinde

Index Scriptorium Estoniae

2008-01-01

Rahvarinde 20. aastapäevale pühendatud konverentsil peetud ettekannete referaadid: Rein Ruutsoo, Dainis Ivans, Kazimiera Danute Prunskiene, Juri Afanasjev, Edgar Savisaar, Kazimieras Motieka, Kauko Sipponen

Kultuurikatel või Linnateater - meer laseb rahasüsti saaja rahval valida / Kertu Kalmus

Index Scriptorium Estoniae

Kalmus, Kertu

2008-01-01

Tallinna linnapea Edgar Savisaar algatas internetis allkirjade kogumise aktsiooni, mille tulemuse põhjal otsustatakse järgmise aasta linnaeelarve panus Linnateatri või Kultuurikatla valmimisse aastal 2011

Coalition agreement of Estonian Centre Party and Estonian Reform Party

Index Scriptorium Estoniae

2001-01-01

Keskerakonna ja Reformierakonna koalitsioonileppe dokument, millele kirjutasid 18 jaanuaril 2002 alla Reformierakonna esimees Siim Kallas ja kantsler Eero Tohver, Keskerakonna esimees Edgar Savisaar ja kantsler Küllo Arjakas

Tapa sõdurid aitasid Läti kamraade

Index Scriptorium Estoniae

2014-01-01

Lätis õppusel Summer Shield 2014 viibivad suurtükiväepataljoni ajateenijad korraldasid heategevusliku toetusjooksu, et koguda raha, toetamaks välisoperatsioonidel langenud Läti sõduritele monumendi püstitamist

Center, Reform parties access government / Aleksei Gunter

Index Scriptorium Estoniae

Gunter, Aleksei, 1979-

2004-01-01

Keskerakonna ja Reformierakonna valitsuse ametisseastumise aastapäeva konverentsil esinesid kõnedega Edgar Savisaar ja Siim Kallas. Politoloog Rein Toomla tutvustas parlamendierakondade põhjal tehtud uurimust erakondade sobivusest koalitsiooni

Выборы как предвестник перемен / Айн Тоотс

Index Scriptorium Estoniae

Тоотс, Айн, 1944-

2009-01-01

Kohalike omavalitsuste volikogude valimiste tulemustest. Endise Tallinna linnapea Hardo Aasmäe sõnul võib Keskerakonna võit kohalikel valimistel sillutada teed Edgar Savisaare edule 2011. a. presidendivalimistel

Lack of promoter IV-driven BDNF transcription results in depression-like behavior.

Science.gov (United States)

Sakata, K; Jin, L; Jha, S

2010-10-01

Transcription of Bdnf is controlled by multiple promoters, in which promoter IV contributes significantly to activity-dependent Bdnf transcription. We have generated promoter IV mutant mice [brain-derived neurotrophic factor (BDNF)-KIV] in which promoter IV-driven expression of BDNF is selectively disrupted by inserting a green fluorescent protein (GFP)-STOP cassette within the Bdnf exon IV locus. BDNF-KIV animals exhibited depression-like behavior as shown by the tail suspension test (TST), sucrose preference test (SPT) and learned helplessness test (LHT). In addition, BDNF-KIV mice showed reduced activity in the open field test (OFT) and reduced food intake in the novelty-suppressed feeding test (NSFT). The mutant mice did not display anxiety-like behavior in the light and dark box test and elevated plus maze tests. Interestingly, the mutant mice showed defective response inhibition in the passive avoidance test (PAT) even though their learning ability was intact when measured with the active avoidance test (AAT). These results suggest that promoter IV-dependent BDNF expression plays a critical role in the control of mood-related behaviors. This is the first study that directly addressed the effects of endogenous promoter-driven expression of BDNF in depression-like behavior. © 2010 The Authors. Genes, Brain and Behavior © 2010 Blackwell Publishing Ltd and International Behavioural and Neural Genetics Society.

Robert Lepikson : ohvitserid teavad tõde / Robert Lepikson ; interv. Kalle Muuli

Index Scriptorium Estoniae

Lepikson, Robert, 1952-2006

2001-01-01

Tulistamisskandaali osaline ja tunnistaja R. Lepikson kirjeldab 1999.a. mais Nursis peaminister M. Laari jt. tulistamist E. Savisaare foto pihta. Vt. samas Peaministri intervjuu TV 3-s ja peaministri avaldus

23. august 1989: Balti kett / koostanud Vesta Reest, Kadi Tarand

Index Scriptorium Estoniae

2013-01-01

Balti riikide ühist protestiavaldust Molotovi-Ribbentropi pakti sõlmimise 50. aastapäeval meenutavad kunstnik Heinz Valk, Euroopa Kontrollikoja liige Kersti Kaljulaid ja Euroopa Parlamendi saadik Vilja Savisaar-Toomast

Perspectieven in de robotica : Overzicht van samenwerkende disciplines

NARCIS (Netherlands)

Horne, C.; De Wolf, S.; Abd El Ghany, M.; Dumay, A.

1986-01-01

Symposium gehouden op 20 juni 1986 in het gebouw van de afdeling der Elektrotechniek, Technische Hogeschool Delft, georganiseerd door de IEEE Student Branch Delft, in samenwerking met IEEE Benelux Section NERG en KIvI

[Aire Veskimäe (toim.). Rahvarinne 1988 : (kakskümmend aastat hiljem)] / Heikki Rausmaa

Index Scriptorium Estoniae

Rausmaa, Heikki

2009-01-01

Tutvustus: Rahvarinne 1988 : (kakskümmend aastat hiljem) / Edgar Savisaar, Rein Ruutsoo, Kadri Simson ... [jt. ; toimetaja Aire Veskimäe ; eessõna: Raimond Kaljulaid ; kujundus: Sergei Didyk]. Tallinn : Tallinna Linnavalitsus, 2008

SIA skandaali neli patust - täna kõvemad kui 10 aastat tagasi / Jaanus Piirsalu

Index Scriptorium Estoniae

Piirsalu, Jaanus, 1973-

2005-01-01

1995. aasta oktoobris aset leidnud lindiskandaalist ja selle osalistest. Vt. samas: SIA skandaal ja järgnenud valitsuskriis; Väljavõte stenogrammist; Meelak: paljud ihkasid kohtus näha Savisaare verd

Harlamov selgitab EAS-i nõukogule BNS-ist lahkumist / Toivo Tänavsuu

Index Scriptorium Estoniae

Tänavsuu, Toivo

2005-01-01

Ettevõtluse Arendamise Sihtasutuse juhatuse esimehe kandidaadilt Oleg Harlamovilt, praeguselt majandus- ja kommunikatsiooniminister Edgar Savisaare nõunikult, plaanitakse küsida tema BNS-ist lahkumise kohta. Lisa: Varrak: EAS pole kellegi rahapump

Кадры для 60 миллионов : Живущий неподалеку от Тарту в Кырвекюла 31-летний Свен Зачек наряду с Ремо Сависааром и Прийтом Весилиндом стал тр

Index Scriptorium Estoniae

Зачек, Свен, 1980-

2012-01-01

Tartu lähedal Kõrvekülas elavast 31-aastasest loodusfotograafist Sven Začekist sai Remo Savisaare ja Priit Vesilinnu kõrval kolmas eestlane, kelle fotosid on avaldanud mainekas loodusajakiri National Geographic

Ansip lays flowers at Bronze Soldier, while government seeks to bridge gap in society

Index Scriptorium Estoniae

2007-01-01

Peaminister Andrus Ansip asetas pärja Pronkssõdurile ja kohtus rahvusvähemuste esindajatega. Eesti meediaruumis oleks vaja enam tähelepanu venekeelsele infole. Linnapea Edgar Savisaare käitumisest rahutuste ajal

Loodusfotograaf Sven Začek saab lindudega sõbraks / interv. Kristjan Roos

Index Scriptorium Estoniae

Začek, Sven, 1980-

2012-01-01

Tartu lähedal Kõrvekülas elavast 31-aastasest loodusfotograafist Sven Začekist sai Remo Savisaare ja Priit Vesilinnu kõrval kolmas eestlane, kelle fotosid on avaldanud mainekas loodusajakiri National Geographic

Riik maksab raudtee eest 2,35 miljardit / Toivo Tänavsuu

Index Scriptorium Estoniae

Tänavsuu, Toivo

2006-01-01

Baltic Rail Service müüb 66% Eesti Raudteest riigile tagasi. Majandus- ja kommunikatsiooniminister Edgar Savisaare, BRS-i nõukogu esimehe Edward Burkhardti seisukohti. Lisa: Laar uut erastamist ette ei võta

Peaminister Parts : "ei" seisukohaga Keskerakonnaga valitsust ei tee / Juhan Parts ; interv. Tuuli Koch

Index Scriptorium Estoniae

Parts, Juhan, 1966-

2003-01-01

Peaminister Juhan Parts tõdeb, et Keskerakonna juht Edgar Savisaar on selgelt väljendanud oma eitavat seisukohta Eesti EL-iga liitumise suhtes ning sellelt pinnalt on võimu jagamine Keskerakonnaga võimatu

Järjekordse ravimiseaduse eelnõu saatusest / Kaidi Vendla

Index Scriptorium Estoniae

Vendla, Kaidi

2007-01-01

Eelnõu kooskõlastusring Rahandus-, Majandus- ja Kommunikatsiooni- ja Justiitsministeeriumi vahel. Rahandusministri Aivar Sõerdi, majandusministri Edgar Savisaare ja justiitsministri Rein Langi põhjendustest, miks nad Sotsiaalministeeriumi poolt esitatud ravimiseaduse muutmise seadust ei kooskõlastanud

Investors ponder private bridge for Narva-Ivangorod / Gary Peach, Joel Alas

Index Scriptorium Estoniae

Peach, Gary

2007-01-01

Tiit Vähi ja Andrei Katkovi lubadusest ehitada Narva jõele uus sild, kuna valitsused silla ehitamises niipea kokkuleppele ei jõua. Tiit Vähi, Edgar Savisaare, Raivo Vare ja Igor Gräzini arvamused

Kui oled puutunud ussipesa / Ken-Marti Vaher

Index Scriptorium Estoniae

Vaher, Ken-Marti, 1974-

2005-01-01

Ilmunud ka: Sakala 15. november lk. 2, Meie Maa 30. november lk. 2. Ken-Marti Vaher kritiseerib Keskerakonna juhi Edgar Savisaare majaostu Keila-Joal ning kummutab laimu oma perekonna varade kohta nende päritolu selgitades

Edgari paralleelne ühiskond / Argo Ideon

Index Scriptorium Estoniae

Ideon, Argo, 1966-

2008-01-01

Autor leiab, et Keskerakonna esimees Edgar Savisaar on rajamas omaenda suveräänset maailma, ning toob selle kohta näiteid: vapimärgid vs teenetemärgid, vabaduskell vs vabadussammas, Kalev Sport vs ETV

Janis Rukshansi sibullilled / Virve Poom

Index Scriptorium Estoniae

Poom, Virve

2006-01-01

Janis Rukshans on üle ilma tuntud sibullillekollektsionäär ja -aretaja, tema kogu peetakse harulduste, sortide rohkuse ja kvaliteedi poolest maailmas ainulaadseks. Vt. samas: Eesti tuntuim sibullillekollektsionäär Sulev Savisaar Janis Rukshansist

Edgar Savisaar : praegu on kõige tähtsam minna valima / Edgar Savisaar

Index Scriptorium Estoniae

Savisaar, Edgar, 1950-

2007-01-01

Keskerakonna esimees vastab küsimustele, mis puudutavad presidendikõnet iseseisvuspäeval, paraadi ärajäämist, pronkssõduri teemat, parlamendivalimiste põhiküsimust ja kampaaniat, tulevast valitsuskoalitsiooni

Edgar Savisaar : aprill mõjutab meid aastaid / Edgar Savisaar ; interv. Frank Sprenk-Dorn

Index Scriptorium Estoniae

Savisaar, Edgar, 1950-

2007-01-01

Tallinna linnapea hinnangul mõjutasid möödunud aastal Eesti majandust kõige enam aprillisündmused, Schengeni viisaruumiga liitumise mõju on sel aastal tühine. Ta loodab, et järgmisel aastal saab Eesti valitsuse, kelle jaoks on kõik majandusvaldkonnad tähtsad

Kolmveerand miljardit maksev terminal avatud / Koit Brinkmann

Index Scriptorium Estoniae

Brinkmann, Koit

2006-01-01

21. juulil avati 750 miljonit krooni maksma läinud AS-i Trendgate nafta ja tumedate naftaproduktide ümberlaadimise terminal. Avamisel viibisid ka majandus- ja kommunikatsiooniminister Edgar Savisaar ja Vene transpordiminister Igor Levitin. Lisa: Trendigate'i neli aastat

Алексий II 1929-2008

Index Scriptorium Estoniae

2008-01-01

Aleksius II meenutavad: Kornelius, Tallinna ja kogu Eesti metropoliit ; Karin Jaani ; Marina Kaljurand ; Dmitri Medvedev, Venemaa president ; Helene Kamzol, Aleksius II sugulane ; Ain Seppik ; Vladimir Illjashevitsh ; Edgar Savisaar ; Jevgeni Tomberg ; Ene Ergma ; Toomas Hendrik Ilves, Eesti Vabariigi president

Skazka o serom volke / Aleksandr Shegedin

Index Scriptorium Estoniae

Shegedin, Aleksandr

2006-01-01

Riigikogu infotunnis vastasid Riigikogu liikmete küsimustele kodakondsuse andmise kohta Andrei Filatovile ning minister Edgar Savisaare Moskva visiidi ja Keskerakonna koostööleppe kohta Ühtse Venemaaga peaminister Andrus Ansip ja välisminister Urmas Paet

Nurgapoliitik kavandab kasiinode alatut riigistamist / Max Kaur ; interv. Sulev Vedler

Index Scriptorium Estoniae

Kaur, Max, 1969-

2007-01-01

Edgar Savisaare endine nõunik Max Kaur esitleb röövkapitalismi ideed, et Eesti riik ei pikenda kasiinode tegevuslubasid ja võtab seejärel nende tegevuse odavalt üle. Kaart: Tallinna mängupõrgud 2007. Lisa

Jah, proua president / Aune Past

Index Scriptorium Estoniae

Past, Aune, 1954-

2006-01-01

Autor analüüsib, kes Eesti lugupeetud naistest võiks asuda presidenditoolile, pakkudes kandidaatideks Marju Lauristini, Siiri Oviiri, Ingrid Rüütli, Ene Ergma; Mari-Ann Kelami, Vilja Savisaare ja Maimu Bergi. Kommenteerivad Valve Raudnask ja Barbi Pilvre

Kuulsuste keeruline elu : [anekdoodid] / Toomas Kall ; karikatuur: Rein Lauks

Index Scriptorium Estoniae

Kall, Toomas, 1947-

2014-01-01

Anekdoodid järgmistest kuulsustest: Luisa Värk, Taavi Rõivas, Ardo Hansson, Bill Gates, Nicolas Sarkozy, Dmitri Medvedev, Edgar Savisaar, Vladimir Putin, Anton Vaino, Astrid Kannel, Viktor Janukovitš, Evelin Ilves, Toomas Hendrik Ilves, Jürgen Ligi, Urve Palo, Indrek Tarand

Vladimir Panov : obvinenija nado dokazõvat / Vladimir Panov ; interv. Jana Toom

Index Scriptorium Estoniae

Panov, Vladimir, 1941-

2008-01-01

Pistisevõtmises süüdistatud Tallinna endine abilinnapea Vladimir Panov vastab küsimustele, mis puudutavad viieaastast kohtuprotsessi ning Äripäeva ja meedia suhtumist talle esitatud süüdistusse. Kommenteerivad: Tarmu Tammerk, Andrus Saar, Edgar Savisaar

Musta pesu pesemine / Ivar Tallo

Index Scriptorium Estoniae

Tallo, Ivar, 1964-

2005-01-01

Valitsuse korruptsioonivastase asjatundjate komisjoni juht aastatel 2002-2003 on seisukohal, et ajakirjandus on ainult üks võimalikest vahenditest tõe tuvastamisel ning lõpliku tõe Edgar Savisaare ja Ain Hanschmidti jt seotud skandaalide kohta peavad selgitama võimuinstitutsioonid

John Kjaer : Nõukogude Liitu ja euroliitu seob vaid sõna "liit" / John Kjaer ; interv. Tuuli Koch

Index Scriptorium Estoniae

Kjaer, John

2003-01-01

Euroopa Komisjoni delegatsiooni juht Eestis John Kjaer vastab küsimustele, mis puudutavad Edgar Savisaare kõnet Keskerakonna kongressil, kus ta võrdles NSV Liitu Euroopa Liiduga; peamisi erinevusi EL-i ja totalitaarriigi vahel, otsuste langetamise põhimõtteid EL-is

Raudtee uus tegevjuht lubab pikki ronge ja rohkem tonne / Earl Currie ; interv. Tuuli Koch

Index Scriptorium Estoniae

Currie, Earl

2001-01-01

Eesti Raudtee juhatuse esimees Earl Currie raudtee eelmise juhtkonna tegutsemisest, uue juhtkonna seisukohast läbirääkimistel ametiühingutega muutustest ER-i juhtimises, olulisematest investeeringutest jm. Earl Currie eluloost. Vt. samas "Rask näeb Savisaare avalduses kommunismi"

Palace kaotas kasutusloa / Peeter Raidla

Index Scriptorium Estoniae

Raidla, Peeter, 1955-

2004-01-01

Väidetavalt surus Tallinna linnapea Edgar Savisaar linnavalitsuse nõupidamisel erakonnakaaslase Viktor Kaasiku tahte kohaselt läbi hotelli Palace kasutusloa tühistamise. Vt. samas: Kuidas nõupidamine kasvas üle istungiks; Uus ekspertiis järgmisel nädalal

Bob Scott: Tallinn 2011 saab oma preemiaraha kätte / Bob Scott ; intervjueerinud Teele Tammeorg

Index Scriptorium Estoniae

Scott, Bob

2010-01-01

Euroopa kultuuripealinnade hindamiskomisjoni esimees räägib oma kohtumisest Tallinna linnapea Edgar Savisaare ja kultuuriministri Laine Jänesega ning sellest, et Tallinnal ja Eestil tuleb lisatoetuse saamiseks saata Euroopa Komisjonile vaid kiri, milles nad kinnitavad, et kultuuripealinna programmi jaoks on raha olemas

Tallinna linnapea Jüri Ratas : Keskerakond ei ole maffia! / Jüri Ratas ; interv. Urmo Soonvald

Index Scriptorium Estoniae

Ratas, Jüri, 1978-

2005-01-01

Tallinna linnapea Jüri Ratas vastab küsimustele, mis puudutavad Rein Ratase Tallinna Vee nõukogu liikmeks määramist, K-kohukse reklaami seost Keskerakonna valimiskampaaniaga, linnapeaks saamist, koostööd teiste poliitikutega, Edgar Savisaare osa Tallinna linna juhtimises

Nõukogude anneksioon 1940. aasta Eesti ajakirjanduse kõverpeeglis / Meelis Saueauk

Index Scriptorium Estoniae

Saueauk, Meelis, 1971-

2010-01-01

Artikkel keskendub Nõukogude anneksiooni esimesele faasile, trükiväljaannete ülevõtmisega kaasnenud muutustele, sellele, kuidas ja kes manipuleerisid Eesti massikommunikatsioonivahenditega. Juunisündmustest Leedus ja Lätis. Vaikivast ajastust pärit traditsioonid kergendasid ajakirjanduse ümberkujundamist. Eesti valitsus oli enda kujundatud rahustamispoliitika kammitsais

Majandusminister Edgar Savisaar loodab arengufondi abil tuua uut hingamist / Edgar Savisaar ; interv. Aivar Reinap

Index Scriptorium Estoniae

Savisaar, Edgar, 1950-

2005-01-01

Majandus- ja kommunikatsiooniminister vastab küsimustele, mis puudutavad arengufondi, võõrtööjõudu, riigiettevõtete vähemusosaluse müümise ideed, reisijateveo doteerimist, sadamatasusid, praamidega seonduvat, põlevkivienergeetikat. Lisad: CV; Ministri viis esimest tööd

Edgar Savisaar : Estonian Air ja Levira tuleb erastada / Edgar Savisaar ; interv. Toivo Tänavsuu

Index Scriptorium Estoniae

Savisaar, Edgar, 1950-

2005-01-01

Ilmunud ka: Infopress 13. mai nr. 19 lk. 148-149. Majandus- ja kommunikatsiooniminister vastab küsimustele, mis puudutavad prioriteete ministriametis, Vene kapitali tulekut Eesti tööstusse, Saaremaa Laevakompanii soovi saada 2006. aastal dotatsiooni tänavusega võrreldes kaks korda rohkem, geenivaramule riigi raha andmist, kust saadakse raha pensionitõusuks, miks eestlane ei taha ettevõtjaks saada. Diagrammid: Mida on riigil müüa?

Edgar Savisaar : soovin, et uus president valitaks riigikogus / Edgar Savisaar ; intervjueerinud Ingvar Bärenklau

Index Scriptorium Estoniae

Savisaar, Edgar, 1950-

2006-01-01

Ilmunud ka: Postimees : na russkom jazõke (2006) 1. veebr. lk. 2. Keskerakonna esimees, majandus- ja kommunikatsiooniminister vastab küsimustele, mis puudutavad Eesti Raudtee võimalikku tagasiostmist riigi poolt, saarte parvlaevaliinide konkurssi, Keskerakonna suhtumist Andrus Ansipi ideesse tulumaksu alandamiseks ning eelseisvaid presidendivalimisi. Lisa: 5 mõtet. Vt. samas: Res Publica ja Isamaaliit Rüütlit presidendina ei näe

Kas New York või põlluriba? / Olev Remsu

Index Scriptorium Estoniae

Remsu, Olev, 1947-

2006-01-01

Autor leiab, et paljud inimesed tunnevad vajadust autoriteedi järele, kellesse nad võiksid uskuda ja kellel oleks ühiskonna üle kindel võim. Eesti poliitikas on olnud ja on kolm isaimidzhiga isiksust: Konstantin Päts, Arnold Rüütel ja Edgar Savisaar

Kofkini kahtlane kiirvõit / Kadi Heinsalu, Sten-Aleks Pihlak

Index Scriptorium Estoniae

Heinsalu, Kadi, 1966-

2007-01-01

Aleksander Kofkini riiulifirma Meriton Food Boutique OÜ sai 25 aastaks rendile kohviku- ja poeruumid endises Pärli kohvikus. Vt. samas: Rentija kahtlustab kokkumängu; Kibekiirelt teoks saanud äritehing; Nemad otsustasid Kofkini firma kasuks; Kristina Traks. Edgar Savisaar ja Alaksander Kofkin - ammused sõbrad

President annab 400 inimesele teenetemärgi / Sven Saun, Kaire Korpe, Lehte Ilves

Index Scriptorium Estoniae

Saun, Sven

2002-01-01

Vabariigi aastapäeva puhul saab teenetemärgi 400 inimest, kelle hulgas on Edgar Savisaare valitsuse ministrid ja need EV Ülemnõukogu liikmed, kes augustis 1991 hääletasid omariikluse poolt. Kommenteerivad ordenisaajad. Samas: Läänemaaga seotud teenetemärgi saajad

Regulation of valine and. alpha. -ketoisocaproate metabolism in rat kidney mitochondria

Energy Technology Data Exchange (ETDEWEB)

Miller, R.H.; Harper, A.E. (Univ. of Wisconsin, Madison (USA))

1988-10-01

Activities of branched-chain amino acid (BCAA) aminotransferase (BCAT) and {alpha}-keto acid dehydrogenase (BCKD) were assayed in mitochondria isolated from kidneys of rats. Rates of transamination of valine and oxidation of keto acids {alpha}-ketoisocaproate (KIC) or {alpha}-ketoisovalerate (KIV) were estimated using radioactive tracers of the appropriate substrate from amounts of {sup 14}C-labeled products formed. Because of the high mitochondrial BCAT activity, an amino acceptor for BCAT, {alpha}-ketoglutarate ({alpha}-KG) or KIC, was added to the assay medium when valine was the substrate. Rates of valine transamination and subsequent oxidation of the KIV formed were determined with 0.5 mM {alpha}-KG as the amino acceptor; these rates were 5- to 50-fold those without added {alpha}-KG. Rates of CO{sub 2} evolution from valine also increased when KIC was present; however, with KIC concentrations above 0.2 mM, rates of CO{sub 2} evolution from valine declined although rates of transamination continued to rise. When 0.05 mM KIC was added to the assay medium, oxidation of KIC was suppressed by inclusion of valine or glutamate in the medium. When valine was present KIC was not oxidized preferentially, presumably because it was also serving as an amino acceptor for BCAT. These results indicate that as the supply of amino acceptor, {alpha}-KG or KIC, is increased in mitochondria not only is the rate of valine transamination stimulated but also the rate of oxidation of the KIV formed from valine. Thus the rate of oxidation of BCAA can be controlled by factors that influence the rate and direction of BCAA transamination and, thereby, the supply of substrate for BCKD.

Regulation of valine and α-ketoisocaproate metabolism in rat kidney mitochondria

International Nuclear Information System (INIS)

Miller, R.H.; Harper, A.E.

1988-01-01

Activities of branched-chain amino acid (BCAA) aminotransferase (BCAT) and α-keto acid dehydrogenase (BCKD) were assayed in mitochondria isolated from kidneys of rats. Rates of transamination of valine and oxidation of keto acids α-ketoisocaproate (KIC) or α-ketoisovalerate (KIV) were estimated using radioactive tracers of the appropriate substrate from amounts of 14 C-labeled products formed. Because of the high mitochondrial BCAT activity, an amino acceptor for BCAT, α-ketoglutarate (α-KG) or KIC, was added to the assay medium when valine was the substrate. Rates of valine transamination and subsequent oxidation of the KIV formed were determined with 0.5 mM α-KG as the amino acceptor; these rates were 5- to 50-fold those without added α-KG. Rates of CO 2 evolution from valine also increased when KIC was present; however, with KIC concentrations above 0.2 mM, rates of CO 2 evolution from valine declined although rates of transamination continued to rise. When 0.05 mM KIC was added to the assay medium, oxidation of KIC was suppressed by inclusion of valine or glutamate in the medium. When valine was present KIC was not oxidized preferentially, presumably because it was also serving as an amino acceptor for BCAT. These results indicate that as the supply of amino acceptor, α-KG or KIC, is increased in mitochondria not only is the rate of valine transamination stimulated but also the rate of oxidation of the KIV formed from valine. Thus the rate of oxidation of BCAA can be controlled by factors that influence the rate and direction of BCAA transamination and, thereby, the supply of substrate for BCKD

Minimalistlikud muinasjutud / Veiko Märka

Index Scriptorium Estoniae

Märka, Veiko, 1964-

2007-01-01

Sisu: Feodaalkord Lapimaal ; Taimetoitlase õudusunenägu ; Savisaare pilt ; Mis mulle meenub, nähes lepatriinut? ; Viagra võluvägi ; Uskumatu loomaporno ; Tunne oma kodumaad ; Tunne oma kodumaad 2. ; Üleskutse Polüneesia puuviljakasvatajatele ; EELK peapiiskopi maja ; Stalingradi lahing ; Tark mees ; Teine Arnold ; Kolmas Arnold

Energy prices hex consumers, officials / Ksenia Repson

Index Scriptorium Estoniae

Repson, Ksenia

2005-01-01

Kütusehinna rekordiline tõus 45 sendi võrra ületab oodatava inflatsiooni ning toob kaasa hinnatõusud ka kõigis teistes kütusest sõltuvates majandusharudes. Majandusminister Edgar Savisaar hoiatas, et elektrienergia hind võib kümne aasta jooksul tõusta kuni 50%

Koolijuhid kaalukeelteks / Jevgeni Karavajev, Matti Martinson ; interv. Peeter Ernits, Anneli Sihvart, Jüri Leesment

Index Scriptorium Estoniae

Karavajev, Jevgeni

2004-01-01

Tallinna linnapea Edgar Savisaare kukutamist kommenteerivad Keskerakonnast Res Publicasse üle läinud Kari gümnaasiumi direktor Jevgeni Karavajev ja Reformierakonna poolt Madagaskarilt koju toodud Rahumäe põhikooli direktor Matti Martinson, kelle hääled said umbusaldushääletusel otsustavateks

Notshnoi Dozor riigikokku? / Edgar Savisaar

Index Scriptorium Estoniae

Savisaar, Edgar, 1950-

2007-01-01

Keskerakonna esimees ja Tallinna linnapea küsib Tallinnas toimunud sündmuste taustal, kuhu jääb Reformierakonna poliitiline vastutus. Tema hinnangul formeerub Eesti poliitiline maastik praegu ümber, valijaskond radikaliseerub ning see toob kaasa muutusi. Tal ei ole enam erilist kahtlust, et Notshnoi Dozori esindajad saavad Riigikogusse

Jackson ja Savisaar / Siim Nestor

Index Scriptorium Estoniae

Nestor, Siim, 1974-

2001-01-01

Michael Jacksoni soolokarjääri 30. aastapäeva tähistamisest Madison Square Gardenis. Uute albumite läbimüükide ja poliitika seostest: M. Jacksoni albumist "Invincible", Paul McCartney uuest albumist "Driving Rain"

Edgar Savisaar: valitsus ei taju, mis linnas ta valitseb / Edgar Savisaar ; interv. Hille Tänavsuu

Index Scriptorium Estoniae

Savisaar, Edgar, 1950-

2007-01-01

Ilmunud ka: Postimees : na russkom jazõke 15. nov. lk. 9. Tallinna linnapea vastab küsimustele, mis puudutavad Keskerakonna ainuvõimu Tallinnas, valimislubaduste täitmist, linnaelanike rahulolu, Keskerakonna toetust, pronksiöö sündmuste mõju Eesti majandusele, riigi ja linnavalitsuse suhteid, pealinna seadust, hüvede saamist linnavalitsuselt, tulevaste valimiste tulemusi. Lisa: Tallinna võim

Edgar Savisaar : Mina ei anna mitte mingit hinnangut / Edgar Savisaar ; interv. Dannar Leitmaa, Holger Roonemaa

Index Scriptorium Estoniae

Savisaar, Edgar, 1950-

2008-01-01

Tallinna linnapea vastused linnavalitsuse pressikonverentsil küsimustele, mis puudutasid Keskerakonna suurrahastaja Oliver Kruuda omavolilist ehitamist Nõmmel. Vt. samas: Holger Roonemaa. Inspektorid ei pannud Kruuda tegevust tähele

Eesti Raudtee juht : valitsus tahab meie äri hävitada / Edward A. Burkhardt ; interv. Priit Rajalo

Index Scriptorium Estoniae

Burkhardt, Edward A.

2005-01-01

Ilmunud ka: Postimees : na russkom jazõke 22. dets., lk 2. Eesti Raudtee omanikud (Baltic Rail Service) kaaluvad ettevõtte mahamüümist valitsusepoolse käitumise tõttu. Tallinna Sadama võimalik osalus. Kommenteerivad Villu Reiljan, Taavi Veskimägi, Ivari Padar, Tõnis Lukas, Andrus Ansip ja Edgar Savisaar

Hypothalamic pituitary thyroid axis and exposure to interpersonal violence in childhood among women with borderline personality disorder

Directory of Open Access Journals (Sweden)

Cave Sinai

2014-05-01

Full Text Available Background: A relationship between exposure to sexual violence and thyroid hormone alterations has been observed among women with posttraumatic stress disorder (PTSD. Women with borderline personality disorder (BPD report a high estimate of childhood trauma. Objective: The aim of the present study was to assess relationships between thyroid hormone measures and exposure to violence in childhood in women with BPD. Method: A total of 92 clinically euthyroid women with BPD (53% with comorbid PTSD diagnosis and at least two prior suicide attempts were assessed with the Karolinska Interpersonal Violence Scales (KIVS. The KIVS contains four subscales with concrete examples of exposure to violence and expressed violent behavior in childhood (aged 6–14 years and during adult life (15 years or older. Baseline thyroid function was evaluated by measuring plasma free and bound triiodothyronine (FT3 and T3, thyroxine (FT4 and T4, and thyroid-stimulating hormone (TSH with immunoassays. The FT3/FT4 ratio was used to estimate peripheral deiodination. Plasma cortisol was also assessed. Results: Sixty-seven percent of patients reported medium high or high level of exposure to interpersonal violence as a child. The FT3/FT4 ratio showed a significant negative correlation with exposure to violence as a child. Patients with PTSD had significantly higher plasma cortisol levels. An ad hoc analysis revealed that the correlation between KIVS exposure to interpersonal violence as a child and FT3/FT4 ratio was significant only in patients with comorbid PTSD. Altered thyroid activity, especially FT3/FT4, levels was associated with exposure to violence in childhood in women with BPD. Conclusion: Severe childhood trauma-related stress may promote lasting altered thyroid levels and/or contribute to the development of psychopathology associated with BPD traits or PTSD.

Eestlased kiidavad Jeltsinit / Kärt Karpa, Tiina Joosu

Index Scriptorium Estoniae

Karpa, Kärt, 1973-

2000-01-01

Vene presidendi Boriss Jeltsini tõusud ja langused. A. Rüütel, E. Savisaar, A. Aasmäe, J. Kahn kommenteerivad kohtumisi tagasiastunud presidendiga. Vt. samas K. Karpa art. Kallas näeb Putini tõusus õukonna intriigi, kus ka T.H. Ilves, A. Tarand ja S. Kallas kommenteerivad B. Jeltsini tagasiastumist

Kired ja kaotused / Aita Kivi

Index Scriptorium Estoniae

Kivi, Aita, 1954-

2002-01-01

Sisu : Corinne Hofmann. Valge Masai; William Somerset Maugham. Teater; Tyne O'Connell. Parimad asjad elus; Sue Townsend. Kuninganna ja mina; Patricia D. Cornwell. Süütõendid; Koopia / Hedda Maurer, Priit Kruus, Mia Leite [Maria Savisaar]; Kristel Salu. Viljaküla Brita memuaarid; Cupido & Psuche; Marie Under. Under armastusest; Sigmund Freud. Argielu psühhopatoloogia

Stimmen zu Estlands Eurobeitritt

Index Scriptorium Estoniae

2011-01-01

Arvamusi Eesti liitumisest eurotsooniga: Toomas Hendrik Ilves, Andrus Ansip, Juhan Parts, Angela Merkel, Jose Manuel Barroso, Olli Rehn, Paul Krugman Anti Poolamets, Nicolaus Heinen, Edgar Savisaar. Lisatud väljavõtted saksakeelsetest ajakirjadest ja ajalehtedest. Euro kasutuselevõttu seostatakse heaolu ja stabiilsusega, samas peetakse üleminekut uuele vääringule liiga kulukaks ja rutakaks

Piiramine, populism ja näidispoomine ehk Tallinna kasiino sõda / Koit Brinkmann

Index Scriptorium Estoniae

Brinkmann, Koit

2008-01-01

Tallinna keskerakondliku linnavalitsuse uus poliitika on kasiinode arvu kontrolli all hoidmine, kasiinode esindajad näevad otsuste taga poliitilist populismi. Küsimustele vastavad Tallinna linnapea Edgar Savisaar ja abilinnapea Taavi Aas. Vt. samas: Trahv veel avamata kasiino eest; Mitu meetrit on vahetu lähedus; Sel aastal lõpevad hasartmängu korraldusload Tallinnas

Edgar Savisaar : poliitilistel kolleegidel läheb tarvis rohkem paksu nahka / Edgar Savisaar ; interv. Tuuli Koch

Index Scriptorium Estoniae

Savisaar, Edgar, 1950-

2007-01-01

Keskerakonna esimees vastab enne Riigikogu valimisi küsimustele, mis puudutavad valimisvõitlust, valitsuse moodustamist, peaministriks olemist, hinnangut peaminister Andrus Ansipile, koostööd Reformierakonna ja Rahvaliiduga, Keskerakonna valimislubadusi ja -programmi ning uusliikmeid, teiste parteide poliitikat. Lisa: Keskerakonna valimislubadusi; 3 küsimust

Eesti Energia salajased uuringud / Sulev Vedler, Tarmo Vahter

Index Scriptorium Estoniae

Vedler, Sulev, 1970-

2007-01-01

Ilmunud ka: Infopress 2. märts nr. 9 lk. 160. Hoitakse salajas Briti konsultatsioonifirma Lexicon Partners poolt koostatud uuringut, mida peaks Eesti riik peale hakkama oma osalusega monopoolses elektriettevõttes Eesti Energia. Majandusminister Edgar Savisaar lasi uuringu ministeeriumisse tuua ning andis juristidele ülesande analüüsida, kui palju saab dokumendist avaldada. Vt. samas: Elektri hind

Riigipea valimise hooajale anti läbinähtav start / Raimo Poom

Index Scriptorium Estoniae

Poom, Raimo

2010-01-01

IRL-i, Reformierakonna, SDE ja roheliste fraktsioon algatasid Vabariigi Presidendi valimise seaduse muutmise, mille vastuvõtmise korral lõpeks olukord, kus suurtes omavalitsustes valib valijamehed välja vaid enamuses olev poliitiline jõud. Autori hinnangul on tegemist selgelt Tallinnale suunatud muudatusega. Edgar Savisaare võimalikust kandideerimisest 2011. a. presidendivalimistel. Vt. ka juhtkiri lk. 2: Presidendivalimiste esimesed noodid

Müütiline miljardipaanika / Edgar Savisaar

Index Scriptorium Estoniae

Savisaar, Edgar, 1950-

2008-01-01

Tallinna linnapea selgitab linna eelarve seisu ja taotlust 500 miljoni krooni laenamiseks (mitte miljardi) ning kinnitab, et Tallinna eelarve seis on parem kui eelarvekärbet tegeval riigil, andes nõu valitsusele ja peaminister Andrus Ansipile

Matsalu festival - aina parem / Ingmar Muusikus ; kommenteerinud Ulvar Käärt

Index Scriptorium Estoniae

Muusikus, Ingmar, 1971-

2011-01-01

Lihulas toimunud 9. Matsalu loodusfilmide festivali fotoprogrammist. Remo Savisaare näitusest "Imelised linnud". Tiit Leito näitusest "Minevikumälestused". Mark Soosaare näitusest "Kihnukielsed ljõnnud". Jarek Jõepera ja Jaan Künnapi näitustest. Näitusest "Meil on elu keset metsa" (Veiko Belials jt.). Ulvar Käärt peapreemia saanud Oliver Götzli filmist "Skandinaavia loodus - Soome" (Saksamaa)

President Ilves sattus YouTube'i tarkust jagama / Tõnu Lilleorg

Index Scriptorium Estoniae

Lilleorg, Tõnu

2008-01-01

President Toomas Hendrik Ilvese majandusteemalisest videoläkitusest portaalis YouTube. Arvamust avaldavad Balti meedia- ja filmikooli õppedirektor Hagi Šein, Riigikogu liige Vilja Savisaar ja kommunikatsioonikonsultant Raul Rebane. Vt. ka juhtkiri lk. 12: Kes tegi? Ilves ise tegi! Õhtulehe arvates vastutab majanduskriisi eest ka president ise. Lisatud karikatuur. Juhtkiri ilmunud ka: Molodjož Estonii 11. dets. 2008, lk. 4, pealk.: Kto vinovat?

Kolm küsimust esimese leedi kandidaatidele

Index Scriptorium Estoniae

2001-01-01

Tiia Tulviste, Kirsti Savi, Sirje Priimägi, Mari-Ann Kelam ja Mari Tarand vastavad küsimustele, kuidas nad suhtuvad sattumisse presidendikampaaniasse, millisena nad näevad enda rolli presidendivalimiste kampaanias ja mida nad tahaksid teha esimese leedina. Eesti presidendi abikaasa rollist ühiskonnast räägivad Jaak Allik, Enn Eesmaa, Toomas Tiivel, Vilja Savisaar ja Gunnar Paal. Parlamendisaadik (M.-A. Kelam)

Oliver Kruuda : Valitsus on loll. Riiki ei juhi keegi / Oliver Kruuda ; interv. Urmo Soonvald

Index Scriptorium Estoniae

Kruuda, Oliver, 1967-

2008-01-01

Ilmunud ka: Vesti Dnja 28. mai lk. 4. Ärimees Oliver Kruuda majandusprobleemide põhjustest Eestis, peaminister Andrus Ansipist, hüpoteegipanga rajamise vajadusest, Eesti ajakirjanduse erapoolikust suhtumisest tema ja Edgar Savisaare tegevusse, Kalevi ja Tere müümisest, Kalev Meedia asutamise ajenditest ja perspektiividest, jõukusest, võlgadest, poegade kasvatamisest. Lisad: Kuidas riigi raha säästa; Kes on Oliver Kruuda?

Seitse raamatut ühtmoodi loodusest, kuid kõik erinevad / Ulvar Käärt, Mari Klein

Index Scriptorium Estoniae

Käärt, Ulvar, 1982-

2009-01-01

Arvustus: Järva, Jaanus. Looduse aasta. Tallinn : Varrak, 2008; Järva, Jaanus. Raba : vaikuses ja varjus. Tallinn : Pegasus, 2008; Savisaar, Remo. Loodus kutsub. Tallinn : Varrak, 2008; Relve, Hendrik. Eesti looduse vägi. Tallinn : Koolibri, 2008; Tartes, Urmas, Põder, Jaak. Legendiloomad. Tallinn : Varrak, 2008; Eesti maastikud. Tallinn : Tänapäev, 2008; Veedla, Peep. Lindudega sõbraks / pildid joonistanud Triinu Ootsing. Tallinn : Berit Grupp, 2008

Jah, proua president / Aune Past

Index Scriptorium Estoniae

Past, Aune, 1954-

2006-01-01

SL Õhtuleht valis välja seitse daami, kes võiksid kandideerida ja saada Eesti Vabariigi presidendiks: Marju Lauristin, Siiri Oviir, Ingrid Rüütel, Ene Ergma, Mari-Ann Kelam, Vilja Savisaar ja Maimu Berg. Avalikkussuhete ja teabekorralduse lektor Aune Past toob välja nende positiivsed küljed ning annab nõu, mis alal võiks iga daam end täiustada

The Importance of Loosely Systematized Game Phases in Sports: The Case of Attack Coverage Systems in High-Level Women’s Volleyball

Directory of Open Access Journals (Sweden)

Lorenzo Laporta

2015-03-01

Full Text Available Change is ubiquitous, but its degree and rate often affords detection of emerging patterns and establishing behavioral dynamics based on expected regularities. Match analysis capitalizes on such regularities, capturing information relevant for enhancing structure and reducing improvisation to a minimum. However, what if a game phase is only loosely regular, defying pattern systematization? Is it still possible to unfold principles of behavior capable of abstracting over-arching patterns? Our research focused on analysis of complex IV (KIV or attack coverage in volleyball. Fourteen matches from the 2013 Volleyball Women’s World Grand Champions Cup were analyzed. Results showed the occurrence of KIV corresponded to fewer than 5% of the total number of actions, and plays where a team successfully conquered a point after attack coverage was circa 1%, meaning this game complex will only make a difference in balanced matches. Overall, twenty-nine attack coverage structures emerged, denoting very high organizational variability. Attack coverage therefore provides an example of principle-based and not structured-based game phase. Associative analysis showed that quick attack tempos constrain the emergence of more complex attack coverage structures. The search for principle-based instead of structure-based game phases may provide useful insights for comprehension of game dynamics and for informing training processes.

Effect of Water Environment on Subcritical Crack Growth of Machinable Ceramics; Kaisakusei seramikkusu no kiretsu shinten tokusei ni oyobosu mizu kankyo no eikyo

Energy Technology Data Exchange (ETDEWEB)

Ikeda, K.; Kaizu, K.; Inotani, T. [Miyazaki Univ., Miyazaki (Japan); Yoshikawa, A.; Adachi, K.; Igaki, H. [Osaka Sangyo Univ., Osaka (Japan)

1997-06-15

The fatigue behavior of ceramics has been discussed on the basis of the relation between stress intensity facter (KI) and crack velocity (V). In this paper, the effect of environment on the relation between KI and V was studied on machinable ceramics (mica glass ceramics) and two kinds of glass ceramics with different grain sizes. The double torsion (DT) technique was used for the determination of the KI-V characteristics under different environments of air and ion-exchanged water. The characteristics of acoustic emission (AE) during stress corrosion cracking of mica glass ceramics was also examined. In water environment, the region II in the KI-V curve, in which crack velocity varies slowly with KI, disappeared. From this experimental fact, it was considered that at high KI, the crack velocity is encouraged by diffusion of the corrosive species to the crack and thus depended on the amount of water. SEM farc tography revealed that mica single crystals in the material caused crack arrest and deflection to occur. It is also found that AE event rate is quantitatively related to the crack velocity. AE measurement can be used in studying the crack propagation behavior of mica glass ceramics. 11 refs., 12 figs., 3 tabs.

Prooviks enesekriitilisemalt, härra Ammas? / Sven Mikser

Index Scriptorium Estoniae

Mikser, Sven, 1973-

2001-01-01

Vastuseks Andres Ammase art. "Savisaar jäi alla Savisaarele." Eesti peaministrile on võõrad nii väärikus, au kui ka ausus. Autor: Keskerakond. Parlamendisaadik. Ilmunud ka: Koit, 27. veebr. 2001, lk. 6; Võrumaa Teataja, 27. veebr. 2001, lk. 2; Vooremaa, 1. märts 2001, lk. 2; Järva Teataja, 3. märts 2001, lk. 2; Nädaline, 3. märts 2001, lk. 5

Võimekate ministrite valitsus

Index Scriptorium Estoniae

1995-01-01

Hinnang uuele valitsusele eelkäijate poolt. M. Laar, A. Tarand - T. Vähi, J. Luik - R. Sinijärv, E. Lippmaa, E. Tarto - A. Öövel, U. Mereste - M. Opmann, J. Adams - P. Varul, E. Nestor - A. Leemets, I. Kannik - E. Savisaar, T. Vilosius - S. Oviir, L. Hänni - L. Tõnisson, P. Olesk - P. Kreitzberg, J. Allik. A. Sirendi - I. Mändmets, V. Hansen - V. Reiljan

Savisaare ja Siffi suur leppimine / Dannar Leitmaa

Index Scriptorium Estoniae

Leitmaa, Dannar, 1982-

2011-01-01

Tallinna Linnavolikogu eraldas Tallinna Spordi- ja Noorsooametile Snelli staadioni rentimiseks 144 000 eurot. Staadion kuulub Personal Power OÜ-le, mis on juba 2010. aastal staadioni kasutamise eest linnalt 2,5 miljoni kroonist rendihinda küsinud, kuid pole seda saanud

Kui Savisaar oli peaminister ja Ilves ajakirjanik

Index Scriptorium Estoniae

2011-01-01

Valitud katkendeid Tarmo Vahteri raamatust "Vaba riigi tulek". Tallinn, 2011. Muuhulgas on ära toodud väljavõte Raadio Vaba Euroopa Eesti toimetuse juhi Toomas Hendrik Ilvese intervjuust Edgar Savisaarega 9. mail 1991

Savisaare-Putini pakt ohustab Eestit / Tunne Kelam

Index Scriptorium Estoniae

Kelam, Tunne, 1936-

2004-01-01

Ilmunud ka: Lääne Elu, 14. dets. 2004, lk. 2; Võrumaa Teataja, 14. dets. 2004, lk. 2; Meie Maa, 14. dets. 2004, lk. 2; Koit, 14. dets. 2004, lk. 6; Hiiu Leht, 14. dets. 2004, lk. 2; Vali Uudised, 15. dets. 2004, lk. 2; Sakala, 15. dets. 2004, lk. 2; Pärnu Postimees, 15. dets. 2004, lk. 15; Nädaline, 16. dets. 2004, lk. 4. Euroopa Parlamendi liige, Isamaaliidu esimees Keskerakonna ja Venemaa partei Ühtne Venemaa koostööleppest

Andrus Ansipi-Edgar Savisaare õppekava / Peeter Kreitzberg

Index Scriptorium Estoniae

Kreitzberg, Peeter, 1948-2011

2005-01-01

Ilmunud ka: Virumaa Nädalaleht 7. oktoober lk. 5. Riigikogu liige on seisukohal, et valitsuse juht ei tohi olla ankurdatud võimaliku mineviku külge, mis teeb võimatuks eetilise hinnangu andmise oma kabinetiliikmete tegudele. Autor rõhutab, et Eesti poliitiline areng ei sõltu mitte niivõrd õigusest, kuivõrd õiglusest, aususest ja otsekohesusest

Savisaar aitab jahtida Kaasikule miljoneid / Peeter Raidla

Index Scriptorium Estoniae

Raidla, Peeter, 1955-

2004-01-01

Tallinna linnavalitsuse eelnõu hotelli Palace kasutusloa tühistamiseks annab advokaat Viktor Kaasikule väidetavalt võimaluse kliendi nimel teenida tagastamise kompensatsioonina kümneid miljoneid kroone. Autor kirjeldab hotelli omandivaidlusega seotud kohtuprotsessi käiku. Lisa: Kaheksas aasta kohtuvaidlustes

Tõusikute laenud maksumaksja kanda / Paul Tammert

Index Scriptorium Estoniae

Tammert, Paul, 1956-

2007-01-01

Ilmunud ka: Põhjarannik, 1. aug. 2007, lk. 2; Severnoje Poberezhje, 1. aug. 2007, lk. 2; Lääne Elu, 2. aug. 2007, lk. 2; Vooremaa, 2. aug. 2007, lk. 2; Võrumaa Teataja, 4. aug. 2007, lk. 2. Majandusteadlase sõnul on Edgar Savisaare ettepanekut aidata laenude tõttu raskustesse sattunud inimesi klassikaline näide sellest, kuidas üritatakse ühendada individualistlikku ärivabadust ja kogukondlikku vastutust. Elitaristliku, individualistliku ja kogukondliku majanduspoliitika mõiste

Supporting Command and Control (C2) of an Embarked Commander: Tunneling SIPRNet Data Across an UNCLAS Wireless LAN

Science.gov (United States)

2011-09-01

that you did to help me through this process. Your efforts and guidance truly made this a success. To SPAWAR SCTD expert Stephanie Koontz , your...ty%20and%20Safety%20Services/05– 500%20Security%20Services/5510.36A.pdf [accessed June 19, 2011]. [28] S. Koontz . “Secret client tunneling...devices - KOV-26 talon user procedures.” Unpublished survey, SPAWAR, Point Loma, CA. [29] S. Koontz . “Secret client tunneling devices - KIV-54 user

Navy Network Dependability: Models, Metrics, and Tools

Science.gov (United States)

2010-01-01

surveillance; TCDL = Tactical Common Data Link; UHF = ultra high frequency; UFO = ultra-high-frequency follow-on; WGS = Wideband Gapfiller Satellite. RAND...VOICE (DMR VALUES) UFO OE-82 UHF LOS VOICE (DMR VALUES) UHF SATCOM VOICE DMR UHF LOS VOICE DMR TVs ADMS KIV-7 COMSEC ADNS SW ADNS II HW ISNS SW ISNS HW...Data Link; UHF = ultra high frequency; UFO = ultra-high-frequency follow-on; WGS = Wideband Gapfiller Satellite. RAND MG1003-1.1 4 Navy Network

Magusaärist lahkuv Kruuda vajas raha investeeringuteks / Lauri Linnamäe

Index Scriptorium Estoniae

Linnamäe, Lauri

2007-01-01

Ärimees Oliver Kruuda müüs Kalevi ja Tere toiduainetööstused Eesti investeerimisfirmale Alta Capital, kelle esindaja Indrek Rahumaa sõnul on mõlemad pooled rahul. Finantsinspektsiooni taunivast suhtumisest müügiettevalmistuste väikeaktsionäride eest saladuses hoidmise pärast. Vt. samas: Võidusõitjast suurinvestor; Savisaar taunis Kalevi müüki; Andrus Karnau intervjuud Oliver Kruudaga: Meediaportaali nimeks saab Kalev.ee. Lisa: Alta Capital Partners; Kalevi grupi struktuur; Skandaalne K-kohuke

CSF 5-HIAA and exposure to and expression of interpersonal violence in suicide attempters.

Science.gov (United States)

Moberg, T; Nordström, P; Forslund, K; Kristiansson, M; Asberg, M; Jokinen, J

2011-07-01

Serotonin is implicated in impaired impulse control, aggression and suicidal behaviour. Low cerebrospinal fluid (CSF) concentrations of the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) have been found in violent suicide attempters, suicide victims and in violent offenders. CSF 5-HIAA concentrations have both genetic and environmental determinants. Childhood trauma may have an effect on central monoamine function as an adult. The aim of this study was to assess the relationship of CSF 5-HIAA and the exposure to and the expression of violence in childhood and during adult life measured with the Karolinska Interpersonal Violence Scale (KIVS). 42 medication free suicide attempters underwent lumbar puncture and were assessed with the Karolinska Interpersonal Violence Scale (KIVS) to assess history of childhood exposure to violence and lifetime expressed violent behaviour. In women, but not in men, CSF 5-HIAA showed a significant negative correlation to exposure to violence during childhood. Furthermore, suicide attempters with low CSF 5-HIAA were more prone to commit violent acts as an adult if exposed to violence as a child compared to suicide attempters with high CSF 5-HIAA. In the non-traumatized group, CSF 5-HIAA showed a significant negative correlation to expressed violent behaviour in childhood. Although central serotonergic function has important genetic determinants, exposure to childhood trauma may also affect serotonergic function. Low serotonergic function may facilitate impaired aggression control in traumatized suicide attempters. Copyright © 2011 Elsevier B.V. All rights reserved.

Valid Savisaare, saad Lengi / Juhan Kivirähk

Index Scriptorium Estoniae

Kivirähk, Juhan, 1957-

2004-01-01

Autor analüüsib Euroopa Parlamendi valimisi nii suletud kui ka avatud nimekirjade korral. Tema hinnangul annavad avatud nimekirjad lisavõimalusi valijatega manipuleerimiseks ning soodustavad kulukate valimiskampaaniate läbiviimist

Kas usud seda? / Loore Ehrlich ; kommenteerinud Remo Savisaar

Index Scriptorium Estoniae

Ehrlich, Loore

2013-01-01

Müüdid: Talvituvad herilased kaitsevad pesa raevukalt; Karu tõuseb enne ründamist tagajalgadele; Kõik ämblikud on ohtlikult mürgised; Puuk kukutab end puude-põõsaste okstelt inimesele; Kõrvahark ronib kõrva ja sealt edasi ajju; Rästik jälitab inimest eesmärgiga rünnata; Nahkhiir on verdihkav vampiir; Ilves ründab inimest puuvõrast turja karates; Näljased hundid murravad inimesi; Sosnovski karuputk kõrvetab; Seen mis ussitab on söögi seen

Elevated lipoprotein(a) and risk of aortic valve stenosis in the general population

DEFF Research Database (Denmark)

Kamstrup, Pia R; Tybjærg-Hansen, Anne; Nordestgaard, Børge G

2014-01-01

OBJECTIVES: The purpose of this study was to determine whether elevated lipoprotein(a) levels and corresponding LPA risk genotypes (rs10455872, rs3798220, kringle IV type 2 repeat polymorphism) prospectively associate with increased risk of aortic valve stenosis (AVS). BACKGROUND: The etiologic...... to 90 mg/dl), and 2.9 (95% CI: 1.8 to 4.9) for levels greater than 95th percentile (>90 mg/dl), versus levels less than the 22nd percentile (rs3798220 minor alleles, and of low number of KIV-2 repeats (trend, all p...

Perioperative epidural or intravenous ketamine does not improve the effectiveness of thoracic epidural analgesia for acute and chronic pain after thoracotomy.

Science.gov (United States)

Tena, Beatriz; Gomar, Carmen; Rios, Jose

2014-06-01

Persistent postsurgical pain (PPP) after thoracotomy effect 50% to 80%. Nerve damage and central sensitization involving NDMDAr activation may play an important role. This study evaluates the efficacy of adding intravenous (IV) or epidural ketamine to thoracic epidural analgesia (TEA) after thoracotomy. Double-blind randomized study on patients undergoing thoracotomy allocated to one of the following: group Kiv (IV racemic ketamine 0.5 mg/kg preincisional +0.25 mg/kg/h for 48 h), group Kep (epidural racemic ketamine 0.5 mg/kg preincisional +0.25 mg/kg/h for 48 h), or group S (saline). Postoperative analgesia was ensured by TEA with ropivacaine and fentanyl. Pain visual analog scales (VAS), Neuropathic Pain Symptom Inventory, Catastrophizing Scale, and Quantitative Sensory Testing, measuring both the peri-incisional and distant hyperalgesia area, were conducted preoperatively and postoperatively until 6 months. Plasma ketamine levels and stability of the analgesic solutions were analyzed. A total of 104 patients were included. PPP incidence was 20% at 6 months. Pain scores on coughing were significantly lower in Kiv and Kep than in S at 24 and 72 hours, but there were no differences afterwards. There were no significant differences in pain at rest, Neuropathic Pain Symptom Inventory, and Catastrophizing Scale, or in the area of mechanical allodynia at any time. Adverse effects were mild. Plasma ketamine levels did not differ significantly between groups. Analgesic solutions were stable. Adding epidural or IV racemic ketamine to TEA after thoracotomy did not lead to any reduction in PPP or allodynia. Epidural administration produced similar plasma ketamine levels to the IV route.

Riigikogus tehakse ka tööd / Vilja Savisaar

Index Scriptorium Estoniae

Savisaar, Vilja, 1962-

2007-01-01

Ilmunud ka: Sakala, 13. juuni 2007, lk. 2; Lääne Elu, 14. juuni 2007, lk. 2; Põhjarannik, 14. juuni 2007, lk. 2; Severnoje Poberezhje, 14. juuni 2007, lk. 2; Vooremaa, 14. juuni 2007, lk. 2; Harju Ekspress, 15. juuni 2007, lk. 8; Järva Teataja, 16. juuni 2007, lk. 2; Koit, 21. juuni 2007, lk. 6. Parlamendiliige Keskerakonna fraktsiooni poolt parlamendis algatatud eelnõudest

Süsteemselt terviklik majanduspoliitika toob raha tagasi / Edgar Savisaar

Index Scriptorium Estoniae

Savisaar, Edgar, 1950-

2007-01-01

Ilmunud ka: Severnoje Poberezhje, 19. okt. 2007, lk. 2; Lääne-Harju Ekspress, 19. okt. 2007, lk. 6; Meie Maa, 22. okt. 2007, lk. 2; Valgamaalane, 23. okt. 2007, lk. 2; Vooremaa, 23. okt. 2007, lk. 2; Vali Uudised, 24. okt. 2007, lk. 2; Virumaa Teataja, 15. nov. 2007, lk. 11. Endine majandusminister tõstatab Eesti majandussituatsiooni olulisemad momendid ning pakub välja omapoolsed majanduslangust vähendavad ja kompenseerivad majanduspoliitilised meetmed

Rüütel kutsus Ansipi, Savisaare js Reiljani Kadriorgu

Index Scriptorium Estoniae

2005-01-01

President Arnold Rüütel kutsus Kadriorgu kolm erakonnajuhti, kes teatasid valmisolekust moodustada uus koalitsioon. Uue koalitsiooni peaministrikandidaadina näevad nad Reformierakonna esimeest Andrus Ansipit

Brain-derived neurotrophic factor signaling and subgenual anterior cingulate cortex dysfunction in major depressive disorder.

Science.gov (United States)

Tripp, Adam; Oh, Hyunjung; Guilloux, Jean-Philippe; Martinowich, Keri; Lewis, David A; Sibille, Etienne

2012-11-01

The subgenual anterior cingulate cortex is implicated in the pathology and treatment response of major depressive disorder. Low levels of brain-derived neurotrophic factor (BDNF) and reduced markers for GABA function, including in the amygdala, are reported in major depression, but their contribution to subgenual anterior cingulate cortex dysfunction is not known. Using polymerase chain reaction, we first assessed the degree to which BDNF controls mRNA expression (defined as BDNF dependency) of 15 genes relating to GABA and neuropeptide functions in the cingulate cortex of mice with reduced BDNF function (BDNF-heterozygous [Bdnf(+/-)] mice and BDNF exon-IV knockout [Bdnf(KIV)] mice). Gene expression was then quantified in the subgenual anterior cingulate cortex of 51 postmortem subjects with major depressive disorder and comparison subjects (total subjects, N=102; 49% were women) and compared with previous amygdala results. Based on the results in Bdnf(+/-) and Bdnf(KIV) mice, genes were sorted into high, intermediate, and no BDNF dependency sets. In postmortem human subjects with major depression, BDNF receptor (TRKB) expression, but not BDNF, was reduced. Postmortem depressed subjects exhibited down-regulation in genes with high and intermediate BDNF dependency, including markers of dendritic targeting interneurons (SST, NPY, and CORT) and a GABA synthesizing enzyme (GAD2). Changes extended to BDNF-independent genes (PVALB and GAD1). Changes were greater in men (potentially because of low baseline expression in women), displayed notable differences from prior amygdala results, and were not explained by demographic or clinical factors other than sex. These parallel human/mouse analyses provide direct (low TRKB) and indirect (low expression of BDNF-dependent genes) evidence in support of decreased BDNF signaling in the subgenual anterior cingulate cortex in individuals with major depressive disorder, implicate dendritic targeting GABA neurons and GABA synthesis

Combining Task Execution and Background Knowledge for the Verification of Medical Guidelines

Science.gov (United States)

Hommersom, Arjen; Groot, Perry; Lucas, Peter; Balser, Michael; Schmitt, Jonathan

The use of a medical guideline can be seen as the execution of computational tasks, sequentially or in parallel, in the face of patient data. It has been shown that many of such guidelines can be represented as a 'network of tasks', i.e., as a number of steps that have a specific function or goal. To investigate the quality of such guidelines we propose a formalization of criteria for good practice medicine a guideline should comply to. We use this theory in conjunction with medical background knowledge to verify the quality of a guideline dealing with diabetes mellitus type 2 using the interactive theorem prover KIV. Verification using task execution and background knowledge is a novel approach to quality checking of medical guidelines.

The issue of E-elections in the Estonian public / Edgar Savisaar

Index Scriptorium Estoniae

Savisaar, Edgar, 1950-

2011-01-01

Keskerkonna esimees leiab, et tähtsaim demokraatia eeltingimus on usaldusväärne valimissüsteem, kuid praegusel kujul ei ole Eesti valimissüsteem läbipaistev, kuna keegi ei saa tagada e-valimiste turvalisust

Savisaar : palk nelja aasta pärast 25 000 krooni / Kadi Heinsalu

Index Scriptorium Estoniae

Heinsalu, Kadi, 1966-

2006-01-01

Ilmunud ka: Delovõje Vedomosti 20. sept. lk. 6. Keskerakonna eesmärgiks on viia keskmine palk Eestis järgmise nelja aastaga 25 000 kroonini - Euroopa Liidu keskmisele tasemele. Diagramm: Palk avalikus sektoris

Konkurentsija stanovitsja tshestneje / Ainars Slesers, Piatras Cesna, Edgar Savisaar ; interv. Olga Pavuk

Index Scriptorium Estoniae

Slesers, Ainars

2006-01-01

Balti riikide transpordi-ala ministrid transpordi arengust Baltimaades, mastaapsematest transpordiprojektidest, kaubavedude koordineerimisest, konkurentsist Venemaa sadamatega, prognoosidest edasiseks arenguks

Major histocompatibility complex (MHC) class III genetics in two Amerindian tribes from southern Brazil: the Kaingang and the Guarani.

Science.gov (United States)

Weg-Remers, S; Brenden, M; Schwarz, E; Witzel, K; Schneider, P M; Guerra, L K; Rehfeldt, I R; Lima, M T; Hartmann, D; Petzl-Erler, M L; de Messias, I J; Mauff, G

1997-10-01

Population genetic studies of the major histocompatibility complex (MHC) class III region, comprising C2, BF and C4 phenotypes, and molecular genetic data are rarely available for populations other than Caucasoids. We have investigated three Amerindian populations from Southern Brazil: 131 Kaingang from Ivaí (KIV), 111 Kaingang (KRC) and 100 Guarani (GRC) from Rio das Cobras. Extended MHC haplotypes were derived after standard C2, BF, C4 phenotyping and restriction fragment length polymorphism (RFLP) analysis with TaqI, together with HLA data published previously by segregation analysis. C2 and BF frequencies corresponded to other Amerindian populations. C4B*Q0 frequency was high in the GRC (0.429) but low in the Kaingang. Unusual C4 alleles were found, viz. C4A*58, A*55 and C4B*22 (presumably non-Amerindian) and aberrant C4A*3 of Amerindian origin occurring with a frequency of 0.223 in the GRC. C4A*3 bands of homo- and heterozygous individuals carrying this variant were Rodgers 1 positive and Chido 1,3 positive, showed a C4A specific lysis type and a C4A like alpha-chain. Polymerase chain reaction studies and sequencing showed that this is based on a C4A*3 duplication with a regular C4A*3 and a partially converted C4A*0304 carrying the C4B specific epitopes Ch 6 and Ch 1,3. Associations of class III haplotypes with particular RFLP patterns were similar to those reported for Caucasoids. The previously described association between combined C4A and CYP21P deletions and the 6.4 kb TaqI fragment was not seen in these Amerindians. This fragment occurred within a regular two locus gene structure in the Kaingang, representing a "short" gene at C4 locus I. C4 and CYP21 duplications were frequently observed. The distribution of extended MHC haplotypes provides evidence for a close relationship between the KIV and KRC and a larger genetic distance between the two Kaingang groups and the GRC.

RADIO ASTROMETRY OF THE CLOSE ACTIVE BINARY HR 5110

Energy Technology Data Exchange (ETDEWEB)

Abbuhl, E.; Mutel, R. L.; Lynch, C. [Department of Physics and Astronomy, University of Iowa, Van Allen Hall, Iowa City, Iowa 52242 (United States); Güedel, M. [Department of Astronomy, University of Vienna, Vienna (Austria)

2015-09-20

The close active binary HR 5110 was observed at six epochs over 26 days using a global very long baseline interferometry array at 15.4 GHz. We used phase referencing to determine the position of the radio centroid at each epoch with an uncertainty significantly smaller than the component separation. After correcting for proper motion and parallax, we find that the centroid locations of all six epochs have barycenter separations consistent with an emission source located on the KIV secondary, and not in an interaction region between the stars or on the F primary. We used a homogeneous power-law gyrosynchrotron emission model to reproduce the observed flux densities and fractional circular polarization. The resulting ranges of mean magnetic field strength and relativistic electron densities are of the order of 10 G and 10{sup 5} cm{sup −3}, respectively, in the source region.

Suicide Risk Associated with Experience of Violence and Impulsivity in Alcohol Dependent Patients.

Science.gov (United States)

Khemiri, Lotfi; Jokinen, Jussi; Runeson, Bo; Jayaram-Lindström, Nitya

2016-01-19

Alcohol dependence (AD) and aggression-impulsivity are both associated with increased suicide risk. There is a need to evaluate clinical tools in order to improve suicide risk assessment of AD patients. The present study consisted of 95 individuals with a diagnosis of AD, consecutively admitted for addiction treatment, compared with 95 healthy controls. Suicidal risk was assessed together with exposure of violence and impulsivity. AD patients reported significantly higher rates of exposure to violence in childhood, as measured by the Karolinska Interpersonal Violence Scale (KIVS), compared to HC. Within the AD group, individuals with history of suicidal ideation and suicidal behavior reported higher levels of violence experience compared to AD individuals without such history. AD patients with previous suicidal ideation scored higher on self-reported impulsivity as assessed by the Barratt Impulsivity Scale (BIS). Our main finding was that experience of trauma and expression of violent behavior, coupled with increased impulsivity are associated with an elevated suicide risk in AD patients. Future longitudinal studies assessing these traits are needed to evaluate their potential role in identifying AD patients at risk of future suicide.

Uus Ansip on Pentus, uus Savisaar Ratas või Simson / Argo Ideon ; kommenteerinud Andrus Ansip

Index Scriptorium Estoniae

Ideon, Argo, 1966-

2011-01-01

USA Tallinna saatkonna Wikileaksi kaudu avalikuks saanud dokumentides analüüsitakse Eesti sisepoliitikat ja riigijuhtide tausta. Peaminister Andrus Ansipist. President Toomas Hendrik Ilvese hinnanguid peaministri kohta üheski Postimehe käsutuses olevas USA Tallinna saatkonna ettekandes ei esitata

Kurss na konteinernõje perevozki / Ainars Shlesers, Algirdas Butkevičius, Edgar Savisaar ; interv. Olga Pavuk

Index Scriptorium Estoniae

Shlesers, Ainars

2007-01-01

Baltimaade transpordiministrite 2006. aasta - millised ministeeriumi algatused on transpordile mõju avaldanud, olulisemad projektid. Hinnang Läti vabamajandustsoonide mõjule ning Venemaa ühinemisele WTOga

Cinnamic acid amides from Tribulus terrestris displaying uncompetitive α-glucosidase inhibition.

Science.gov (United States)

Song, Yeong Hun; Kim, Dae Wook; Curtis-Long, Marcus J; Park, Chanin; Son, Minky; Kim, Jeong Yoon; Yuk, Heung Joo; Lee, Keun Woo; Park, Ki Hun

2016-05-23

The α-glucosidase inhibitory potential of Tribulus terrestris extracts has been reported but as yet the active ingredients are unknown. This study attempted to isolate the responsible metabolites and elucidate their inhibition mechanism of α-glucosidase. By fractionating T. terristris extracts, three cinnamic acid amide derivatives (1-3) were ascertained to be active components against α-glucosidase. The lead structure, N-trans-coumaroyltyramine 1, showed significant inhibition of α-glucosidase (IC50 = 0.42 μM). Moreover, all active compounds displayed uncompetitive inhibition mechanisms that have rarely been reported for α-glucosidase inhibitors. This kinetic behavior was fully demonstrated by showing a decrease of both Km and Vmax, and Kik/Kiv ratio ranging between 1.029 and 1.053. We progressed to study how chemical modifications to the lead structure 1 may impact inhibition. An α, β-unsaturation carbonyl group and hydroxyl group in A-ring of cinnamic acid amide emerged to be critical functionalities for α-glucosidase inhibition. The molecular modeling study revealed that the inhibitory activities are tightly related to π-π interaction as well as hydrogen bond interaction between enzyme and inhibitors. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

Toidutööstus panustab detsembris jõulutoodetele. Pühad toovad käibelisa / Ain Alvela, Ketlin Rauk ; kommenteerinud Ruth Roht, Marek Viilol, Simmo Kruustük, Imre Sokk

Index Scriptorium Estoniae

Alvela, Ain, 1967-

2011-01-01

Spetsiaalsed jõulutooted aitavad aasta lõpul suurendada toiduainetööstuste käivet. ASi Atria Eesti müügi- ja turundusdirektori Margus Masingu, ASi Fazer Eesti juhatuse esimehe Kristjan Kongo ja ASi Salvest turundusdirektori Ain Nõlvaku kommentaare

De Novo Biosynthesis of Glutarate via α-Keto Acid Carbon Chain Extension and Decarboxylation Pathway in Escherichia coli.

Science.gov (United States)

Wang, Jian; Wu, Yifei; Sun, Xinxiao; Yuan, Qipeng; Yan, Yajun

2017-10-20

Microbial based bioplastics are promising alternatives to petroleum based synthetic plastics due to their renewability and economic feasibility. Glutarate is one of the most potential building blocks for bioplastics. The recent biosynthetic routes for glutarate were mostly based on the l-lysine degradation pathway from Pseudomonas putida that required lysine either by feeding or lysine overproduction via genetic manipulations. Herein, we established a novel glutarate biosynthetic pathway by incorporation of a "+1" carbon chain extension pathway from α-ketoglutarate (α-KG) in combination with α-keto acid decarboxylation pathway in Escherichia coli. Introduction of homocitrate synthase (HCS), homoaconitase (HA) and homoisocitrate dehydrogenase (HICDH) from Saccharomyces cerevisiae into E. coli enabled "+1" carbon extension from α-KG to α-ketoadipate (α-KA), which was subsequently converted into glutarate by a promiscuous α-keto acid decarboxylase (KivD) and a succinate semialdehyde dehydrogenase (GabD). The recombinant E. coli coexpressing all five genes produced 0.3 g/L glutarate from glucose. To further improve the titers, α-KG was rechanneled into carbon chain extension pathway via the clustered regularly interspersed palindromic repeats system mediated interference (CRISPRi) of essential genes sucA and sucB in tricarboxylic acid (TCA) cycle. The final strain could produce 0.42 g/L glutarate, which was increased by 40% compared with the parental strain.

The 16th Werner Brandt Workshop on charged particle penetration phenomena

International Nuclear Information System (INIS)

1996-05-01

This report contains viewgraphs on the following topics: impact parameter dependence of charge transfer and energy loss; nonlinear dynamical response of the electron gas: comparison of some simple theories; stopping of ultrarelativistic ions in solids (33.2-TeV 108 Pb); collective excitation in reduced dimensionality; collective states in atoms and cluster; plasmon coupling with external probes; atomic collisions with antiprotons; layer-number scaling in ultra-thin film stopping and energetics; atom-surface scattering under classical conditions; nonlinear effect of sweeping-out electrons in stopping power and electron emission in cluster impacts; electron emission from fast grazing collisions of ions with silicon surfaces; electron emission from ultra-thin carbon foils by kiV ions; Auger rates for highly charged ions in metals; Auger and plasmon assisted neutralization at surfaces; low energy ( + and F - ions transmission through condensed layers of water: enhancement and attenuation processes; charge transfer for H interacting with Al: atomic levels and linewidths; scattered projectile angular and charge state distributions for grazing collisions of multicharged ions with metal and insulator single crystal targets; the prolate hyperboloidat model in scanning probe microscopy; scanning probe microscopy of large biomolecules; microcantilever sensors; solution of the Fokker-Planck equation for electron transport using analytic spatial moments; and effective charge parametrization for z = 3-17 projectiles in composite targets

Family history of suicide and exposure to interpersonal violence in childhood predict suicide in male suicide attempters.

Science.gov (United States)

Rajalin, Mia; Hirvikoski, Tatja; Jokinen, Jussi

2013-05-15

Family studies, including twin and adoption designs, have shown familial transmission of suicidal behaviors. Early environmental risk factors have an important role in the etiology of suicidal behavior. The aim of the present study was to assess the impact of family history of suicide and childhood trauma on suicide risk and on severity of suicide attempt in suicide attempters. A total of 181 suicide attempters were included. Family history of suicide was assessed with the Karolinska Suicide History Interview or through patient records. Childhood trauma was assessed with the Karolinska Interpersonal Violence Scale (KIVS) measuring exposure to violence and expressed violent behavior in childhood (between 6 and 14 years of age) and during adult life (15 years or older). Suicide intent was measured with the Freeman scale. Male suicide attempters with a positive family history of suicide made more serious and well planned suicide attempts and had a significantly higher suicide risk. In logistic regression, family history of suicide and exposure to interpersonal violence as a child were independent predictors of suicide in male suicide attempters. The information about family history of suicide and exposure to interpersonal violence as a child derives from the patients only. In the first part of the inclusion period the information was collected from patient records. The results of this study imply that suicides among those at biological risk might be prevented with the early recognition of environmental risks. Copyright © 2012 Elsevier B.V. All rights reserved.

Paradoxical sleep deprivation changes testicular malondialdehyde and caspase-3 expression in male rats

Directory of Open Access Journals (Sweden)

Fitranto Arjadi

2015-08-01

Full Text Available BACKGROUND Sleep deprivation is a significant problem among adult men and is considered as a risk factor for several diseases. Paradoxical sleep deprivation (PSD induces Leydig cell apoptosis through elevation of corticosterone, with testicular malondialdehyde (MDA and Leydig cell caspase-3 expression as parameters. The aim of this study was to observe testicular MDA level and caspase-3 expression treated with paradoxical sleep deprivation (PSD, immobilization, and footshock stress and to determine the stress model with a significant effect in white male rats (Rattus norvegicus . METHODS This experimental randomized study of posttest only with control group design was conducted on 24 white male Wistar strain rats, randomly allocated into four treatment groups, i.e. control (K1 without any stress treatment, PSD (KII, immobilization (KIII, and footshock stress (KIV. Treatments were given for 25 days to produce chronic stress. Testicular MDA concentration was examined by the ELISA method while caspase-3 was examined by the TUNEL method. RESULTS Mean testicular MDA concentration with one-way ANOVA test showed differences in means between the groups (p=0.000 and post hoc Tukey-HSD test showed significant results between PSD stress group versus control, immobilization and footshock stress groups. One-way ANOVA test showed a significant difference in caspase-3 expression in at least two treatment groups (p=0.008 and post-hoc Tuckey-LSD test showed significant differences between controls and all stress groups. CONCLUSION Sleep deprivation is a type of stress inducing changes in testicular MDA concentration and caspase-3 expression in male rat testes.

Mechanical properties of carving wax with various Ca-bentolite filter composition

Directory of Open Access Journals (Sweden)

Widjijono Widjijono

2009-09-01

Full Text Available Background: The carving wax is used as a medium in dental anatomy study. This wax composes of many waxes and sometimes a filler is added. Carving wax is not sold in Indonesian market. Whereas the gradients of carving wax such as beeswax, paraffin and bentonite are abundant in Indonesia. Based on that fact, to make high quality and standard,the exact composition if this carving wax should be known. Purpose: The aim of this study was to investigate the effect of carving wax composition with Ca-bentonite filler on the melting point, hardness, and thermal expansion. Methods: Five carving wax compositions were made with paraffin, Ca-bentonite, carnauba wax, and beeswax in ratio (% weight: 50:20:25:5 (KI, 55:15:25:5 (KII, 60:10:25:5 (KIII, 65:5:25:5 (KIV, 70:0:25:5(KV. All components were melted, then poured into the melting point, hardness, and thermal expansion moulds (n = 5. Three carving wax properties were tested: melting point by melting point apparatus; hardness by penetrometer; thermal expansion by digital sliding caliper. The data were analyzed statistically using One-Way ANOVA and LSD0.05. Result: The Ca-bentonite addition influenced the melting point and thermal expansion of carving wax with significant differences between KI and other groups (p < 0.05. Ca-bentonite addition influenced the carving wax hardness and the mean differences among the groups were significant (p < 0.05. Conclusion: Ca-bentonite filler addition on the composition of carving wax influenced the physical and mechanical properties. The carving wax with high Ca-bentonite concentration had high melting point and hardness, but low thermal expansion.

A Higgs-bozon

CERN Document Server

Dezso, Horvath

2017-01-01

A részecskefizika általánosan elfogadott és az elmúlt 40 év alatt sokszorosan igazolt elmélete, a standard modell valamennyi alkatrészét sikerült megfigyelni és tanulmányozni a Higgs-bozon kivételével. A CERN nagy hadronütköztetője (LHC), a világ legnagyobb részecskegyorsítója is elsősorban a Higgs-részecske kimutatására épült. 2012 közepére az LHC két óriási mérőberendezése, a sok ezer fizikus részvételével épült CMS és ATLAS megfigyelt egy - a Higgs-bozon elméletileg megjósolt tulajdonságaival rendelkező - új részecskét. A könyv áttekinti a standard modell elméletét és a Higgs-részecske feltételezett tulajdonságait, majd összefoglalja az LHC Higgs-keresési eredményeit és a hozzájuk vezető utat. Függelékben ismerteti a könyvben előforduló fizikusok életrajzát és bizonyos fizikai fogalmak részletesebb leírását. A 2013-as fizikai Nobel-díjat Peter Higgs és François Englert kapták megosztva a Higgs-mechanizmus és a Higgs-bozon elmé...

The correlation between Salter's criteria for avascular necrosis of the femoral head and Kalamchi's prognostic classification following the treatment of developmental dysplasia of the hip.

Science.gov (United States)

Tsukagoshi, Y; Kamegaya, M; Kamada, H; Saisu, T; Morita, M; Kakizaki, J; Tomaru, Y; Yamazaki, M

2017-08-01

The aim of this study was to evaluate the correlation between Salter's criteria and Kalamchi's classification of avascular necrosis in patients treated for developmental dysphasia of the hip (DDH). The study involved a retrospective analysis of 123 patients (123 hips) with DDH treated by operative and non-operative reduction before the age of two years, with a minimum follow-up of ten years. Salter's criteria (S1 to S4) were determined from radiographs obtained at one to two years post-reduction, whilst the Kalamchi grade was determined from radiographs obtained at ten or more years of age. Early post-reduction radiographs were also used to evaluate the centre-head distance discrepancy (CHDD) and the occurrence of a dome-shaped deformity of the proximal femoral metaphysis (D-shaped metaphysis). The prognosis was described as good (Kalamchi grade K0 or KI), fair (Kalamchi grade KII) or poor (Kalamchi grade KIII or KIV) for analysis and correlation with the early Salter criteria, CHDD and D-shaped metaphysis. S1 and S2 criteria were predictive of a poor prognosis. The outcome following S3, S4 and S3 + S4 varied; 18 (40%) had a good prognosis, 17 (38%) a fair prognosis and ten (22%) a poor prognosis. A CHDD ≥ 10% and a D-shaped metaphysis were also predictive of a poor prognosis. The Salter criteria were predictive of the Kalamchi grade of avascular necrosis in patients with DDH aged ten or more years after reduction of the hip. Cite this article: Bone Joint J 2017;99-B:1115-20. ©2017 The British Editorial Society of Bone & Joint Surgery.

Absence of an association of human polyomavirus and papillomavirus infection with lung cancer in China: a nested case–control study

International Nuclear Information System (INIS)

Colombara, Danny V.; Manhart, Lisa E.; Carter, Joseph J.; Hawes, Stephen E.; Weiss, Noel S.; Hughes, James P.; Qiao, You-Lin; Taylor, Philip R.; Smith, Jennifer S.; Galloway, Denise A.

2016-01-01

Studies of human polyomavirus (HPyV) infection and lung cancer are limited and those regarding the association of human papillomavirus (HPV) infection and lung cancer have produced inconsistent results. We conducted a nested case–control study to assess the association between incident lung cancer of various histologies and evidence of prior infection with HPyVs and HPVs. We selected serum from 183 cases and 217 frequency matched controls from the Yunnan Tin Miner’s Cohort study, which was designed to identify biomarkers for early detection of lung cancer. Using multiplex liquid bead microarray (LBMA) antibody assays, we tested for antibodies to the VP1 structural protein and small T antigen (ST-Ag) of Merkel cell, KI, and WU HPyVs. We also tested for antibodies against HPV L1 structural proteins (high-risk types 16, 18, 31, 33, 52, and 58 and low-risk types 6 and 11) and E6 and E7 oncoproteins (high risk types 16 and 18). Measures of antibody reactivity were log transformed and analyzed using logistic regression. We found no association between KIV, WUV, and MCV antibody levels and incident lung cancer (P-corrected for multiple comparisons >0.10 for all trend tests). We also found no association with HPV-16, 18, 31, 33, 52, and 58 seropositivity (P-corrected for multiple comparisons >0.05 for all). Future studies of infectious etiologies of lung cancer should look beyond HPyVs and HPVs as candidate infectious agents. The online version of this article (doi:10.1186/s12885-016-2381-3) contains supplementary material, which is available to authorized users

Impact of hypoglycemia on daily life of type 2 diabetes patients in Ukraine

Directory of Open Access Journals (Sweden)

Mandrik O

2013-07-01

Full Text Available Olena Mandrik,1–3 Johan L Severens,1 Olena Doroshenko,4 Vladymir Pan'kiv,5 Nonna Kravchun,6 Maryna Vlasenko,7 Mykola Hulchiy,8 Maryna Baljuk,9 Yuliia Komisarenko,10 Eugene Martsynik,11 Liubov Sokolova,12 Olga Zalis'ka,2 Boris Mankovsky131Erasmus University Rotterdam, Rotterdam, the Netherlands; 2Danylo Halytsky Lviv National Medical University, Lviv, 3MSD Ukraine, 4Ukrainian Institute for Strategic Research, 5Ukrainian Scientific Centre of Endocrine Surgery, 6Institute of Problems of Endocrine Pathology na VY Danylevskogo, Ukrainian Academy of Medical Sciences, Kyiv, 7Vinnitsa National Medical University named after MI Pyrogov, Vinnytsia, 8Kyiv City Teaching Endocrinological Center, Kyiv, 9Danilevsky Institute of Endocrine Pathology Problems, Ukrainian Academy of Medical Sciences, Kharkov, 10OO Bogomolets National Medical University, Kyiv, 11Medical Academy of Dnepropetrovsk, Dnepropetrovsk, 12Institute of Endocrinology and Metabolism after V.P. Komissarenko, National Academy of Medical Sciences of Ukraine, Kyiv, 13PL Shupik National Medical Academy of Postgraduate Education, Kyiv, UkraineAbstract: This study evaluates the impact of hypoglycemia on the lives of Ukrainian patients with type 2 diabetes mellitus. The secondary objective was to explore patient–physician relationships and the attitudes of patients towards various informational resources on diabetes management. Three focus groups with 26 patients were conducted. Qualitative information was evaluated using content analysis. The results show that patients with type 2 diabetes mellitus in Ukraine are adapting to potential attacks of hypoglycemia; however, they still experience periodic manifestations of hypoglycemia that significantly affect their psychological well-being. This result is similar to observations made in other countries. Ukrainian patients >40 years old mainly receive information on disease management from endocrinologists, and rarely use internet resources on diabetes

Determination of branched chain amino acids, methionine, phenylalanine, tyrosine and alpha-keto acids in plasma and dried blood samples using HPLC with fluorescence detection.

Science.gov (United States)

Kand'ár, Roman; Záková, Pavla; Jirosová, Jana; Sladká, Michaela

2009-01-01

The determination of branched chain amino acids [BCAA; valine (Val), leucine (Leu), isoleucine (Ile)], alpha-keto acids derived from BCAA [BCKA; alpha-ketoisovaleric acid (KIV), alpha-ketoisocaproic acid (KIC), alpha-ketomethylvaleric acid (KMV)], methionine (Met), phenylalanine (Phe) and tyrosine (Tyr) is currently the most reliable approach for the diagnosis of maple syrup urine disease (MSUD), hypermethioninemia, phenylketonuria (PKU) and tyrosinemia. The aim of this study was to develop rapid and simple HPLC methods for measurement of BCAA, Met, Phe, Tyr and BCKA in plasma and dried blood samples. Samples of peripheral venous blood with EDTA as anticoagulant were obtained from a group of healthy blood donors (n=70, 35 females, 27-41 years of age and 35 males, 28-43 years of age). Blood-spot samples from a group of newborns (n=80, 40 girls and 40 boys 3-5 days of age) were collected onto #903 Specimen Collection Paper and allowed to dry for at least 24 h before analysis. Prior to separation, the amino acids (AA) were derivatized with o-phthaldialdehyde (OPA) and BCKA with o-phenylenediamine (OPD). Reverse phase column chromatography (LiChroCart 125-4 Purospher RP-18e, 5 microm) was used for separation and fluorescence detection used to monitoring of effluent. For AA analysis, 25 mmol/L sodium hydrogenphosphate-methanol (90:10, v/v), pH 6.5+/-0.1 was used as mobile phase A and 100% methanol was used as mobile phase B. Measurement of BCKA used a mixture of methanol and deionized water (55:45, v/v) as mobile phase A and mobile phase B consisted of 100% methanol. Analytical performance of these methods was satisfactory for the determination of all AA and BCKA. The intra-assay and inter-assay coefficients of variation were below 10% and recovery ranged from 90%-110%. We have developed simple, rapid and selective HPLC methods with fluorescence detection for the determination of BCAA, Met, Phe, Tyr and BCKA in plasma and dried blood samples.

A shock tube study of C4–C6 straight chain alkenes + OH reactions

KAUST Repository

Khaled, Fathi

2016-06-28

Alkenes are known to be good octane boosters and they are major components of commercial fuels. Detailed theoretical calculations and direct kinetic measurements of elementary reactions of alkenes with combustion radicals are scarce for C4 alkenes and they are practically absent for C5 and larger alkenes. The overall rate coefficients for the reaction of OH radical with 1-butene (CH CHCH CH, k ), 1-pentene (CH CHCH CH-CH, k ), cis/trans 2-pentene (CH CHCHCH CH, k and k ), 1-hexene (CH CHCH CH CH CH, k ) and cis/trans 2-hexene (CH CHCHCH CH CH, k and k ) were measured behind reflected shock waves over the temperature range of 833-1377K and pressures near 1.5atm. The reaction progress was followed by measuring mole fraction of OH radicals near 306.7nm using UV laser absorption technique. It is found that the rate coefficients of OH+trans-2-alkenes are larger than those of OH+cis-2-alkenes, followed by OH+1-alkenes. The derived Arrhenius expressions for the overall rate coefficients (in cm.mol.s) are:. kI=(4.83±0.03)104.T2.72±0.01.exp(940.8±2.9cal/molRT)(946K-1256K) + kII=(5.66±0.54)10-1.T4.14±0.80.exp(4334±227cal/molRT)(875K-1379K) + kIII=(3.25±0.12)104.T2.76±0.5.exp(1962±83cal/molRT)(877K-1336K) + kIV=(3.42±0.09)104.T2.76±0.5.exp(1995±59cal/molRT)(833K-1265K) + kV=(7.65±0.58)10-4.T5±1.exp(5840±175cal/molRT)(836K-1387K) + kVI=(2.58±0.06)106.T2.17±0.37.exp(1461±55cal/molRT)(891K-1357K) + kVII=(3.08±0.05)106.T2.18±0.37.exp(1317±38cal/molRT)(881K-1377K) +

A shock tube study of C4–C6 straight chain alkenes + OH reactions

KAUST Repository

Khaled, Fathi; Badra, Jihad; Farooq, Aamir

2016-01-01

Alkenes are known to be good octane boosters and they are major components of commercial fuels. Detailed theoretical calculations and direct kinetic measurements of elementary reactions of alkenes with combustion radicals are scarce for C4 alkenes and they are practically absent for C5 and larger alkenes. The overall rate coefficients for the reaction of OH radical with 1-butene (CH CHCH CH, k ), 1-pentene (CH CHCH CH-CH, k ), cis/trans 2-pentene (CH CHCHCH CH, k and k ), 1-hexene (CH CHCH CH CH CH, k ) and cis/trans 2-hexene (CH CHCHCH CH CH, k and k ) were measured behind reflected shock waves over the temperature range of 833-1377K and pressures near 1.5atm. The reaction progress was followed by measuring mole fraction of OH radicals near 306.7nm using UV laser absorption technique. It is found that the rate coefficients of OH+trans-2-alkenes are larger than those of OH+cis-2-alkenes, followed by OH+1-alkenes. The derived Arrhenius expressions for the overall rate coefficients (in cm.mol.s) are:. kI=(4.83±0.03)104.T2.72±0.01.exp(940.8±2.9cal/molRT)(946K-1256K) + kII=(5.66±0.54)10-1.T4.14±0.80.exp(4334±227cal/molRT)(875K-1379K) + kIII=(3.25±0.12)104.T2.76±0.5.exp(1962±83cal/molRT)(877K-1336K) + kIV=(3.42±0.09)104.T2.76±0.5.exp(1995±59cal/molRT)(833K-1265K) + kV=(7.65±0.58)10-4.T5±1.exp(5840±175cal/molRT)(836K-1387K) + kVI=(2.58±0.06)106.T2.17±0.37.exp(1461±55cal/molRT)(891K-1357K) + kVII=(3.08±0.05)106.T2.18±0.37.exp(1317±38cal/molRT)(881K-1377K) +

Arvo Pärt: Kui kannatab üks inimene, siis kannatab kogu maailm! / Arvo Pärt, Nora Pärt ; intervjueerinud Yana Toom, Maarja-Liis Arujärv, Aleksandr Zukerman ; kommenteerinud Edgar Savisaar

Index Scriptorium Estoniae

Pärt, Arvo, 1935-

2010-01-01

Arvo Pärt ja tema abikaasa Nora Pärt andsid Türgis enne Pärdi uudisteose "Aadama itk" esiettekannet intervjuu, kus rääkisid nii nende raskustest Läände elama asumisel kui uudisteose sügavamast mõttest

Szaknyelvi nyelvhasználat és kommentelés Egy internetes szakmai honlap cikkeinek és fórumszövegeinek szemantikai-pragmatikai jellemzői

Directory of Open Access Journals (Sweden)

Sólyom, Réka

2015-10-01

Full Text Available Terminological language use and commenting: Semantic-Pragmatic features of a professional online website's articles and forum texts *** The paper analyses the semantic-pragmatic features of articles and related comments in a professional website called Menedzsment Fórum ('Management Forum', http://mfor.hu in a functional-cognitive framework. The goal of the analyses is to reveal those organising principles of meaning and understanding that prevail in articles and comments related to different topics of the website. With the help of some arbitrarily chosen examples, the present analysis shows that the occurrence of conceptual metaphors and metonymies, schemas, and conceptual integration, can foster understanding processes up to a great extent. During the analyses, semantic-pragmatic features of single-scope networks, double-scope networks will be studied, and a more complex expression considered as a multiple-scope network (digital Stone Age will be analysed and represented graphically within the framework of conceptual integration. *** A tanulmány egy internetes szakmai honlap, a Menedzsment Fórum (http://mfor.hu néhány cikkének és a cikkekhez kapcsolódó fórumszöveg-bejegyzéseknek szemantikai-pragmatikai jellemzőit elemzi funkcionális-kognitív keretben. Az elemzések célja azoknak a jelentés- és megértésszervező elveknek a feltárása, amelyek a különféle témájú cikkekben és kommentekben érvényesülnek. Jelen vizsgálat néhány önkényesen kiválasztott idézet elemzésével bemutatja, hogy a fogalmi metaforák és metonímiák, alakzatok, illetve a fogalmi integráció megjelenése a szövegekben nagymértékben segíti a megértési, befogadási folyamatokat. Az elemzések során sor kerül egy- és kétoldalú hálózatként megjelenő szavak, kifejezések elemzésére, valamint egy többoldalú hálózatként megjeleníthető, bonyolultabb felépítésű kifejezés (digitális kőkorszak szemantikai

A javítási műveletek jelöltségi hipotézise

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Zsuzsanna Németh

2014-12-01

Full Text Available The markedness hypothesis of repair operations In this paper, using conversation analysis, I propose a model describing the technology of four repair operations, namely, recycling, replacement, insertion, and aborting relative to each other on the basis that they inherently halt the progressivity of the current turn-at-talk. As violating the preference for progressivity is a marked usage, interpreting the property of halting progressivity as a system of binary features in the case of the four repair operations enables us to apply the theory of markedness to describe the technology of the repair operations relative to each other. Testing the model has been possible only in an indirect way by setting up a sub-hypothesis. I have argued that not only their functions but also their degree of markedness plays a role in the selection of repair operations employed in carrying out the same action. I have tested the sub-hypothesis on a Hungarian corpus. The results support the hypothesis. A tanulmány a konverzációelemzés elméleti keretében négy javítási művelet, az ismétlés, a beszúrás, a csere és a törlés technológiáját hasonlítja össze kísérletet téve egy olyan modell létrehozására, amely a javítási műveletek jelöltségét feltételezi. Ennek alapja, hogy a spontán társalgások során alkalmazott javítási jelenségek felfüggesztik a folyamatban levő forduló, és ezáltal a folyamatban levő cselekvés előrehaladását. Mivel a progresszivitás fenntartása általános preferencia a társalgásban, megszakítása jelölt nyelvhasználatot eredményez, amelyet a négy művelet esetében három bináris jegy rendszereként értelmezhetünk (retrospektivitás, redundancia, nem megfelelő szegmentum. A modell tesztelése egy magyar nyelvű korpuszon történt egy szub-hipotézis segítségével, amelynek lényege, hogy az egyazon cselekvés során alkalmazott javítási műveletek kiválasztásában funkcióik mellett

How established companies can master disruptive innovation like startups? Achieving innovation excellence and disruptive ability = Miként tudnak az érett vállalatok startupok módjára megszakító innovációkat létrehozni? Út az innovációs kiválóság és a diszrupciós képesség felé

OpenAIRE

Kristóf, Péter

2016-01-01

Emerging exponential technologies empower entrepreneurs to create a world of abundance. For established companies it implicates that if they are not the ones creating this abundance, somebody else will, by disrupting their technology and market. In order to keep pace they have to learn how to pick up and apply exponential mindset and master disruptive innovation like startups – even within their established organizations.