Ladislau Steiner, 1920-2013.

Science.gov (United States)

Leksell, Dan; Lindquist, Christer E H

2013-09-01

The authors commemorate the life and career of Dr. Ladislau Steiner, one of the world's most highly regarded neurosurgeons, from Stockholm and Charlottesville, Virginia, who has died at age 92. They review the events of Dr. Steiner's early life, including his early training in his native Romania, his escape with his family from East Berlin, and his postgraduate training in neurosurgery at the Karolinska Institute in Stockholm. Dr. Steiner's work in the development of microsurgery and his collaboration with Lars Leksell in the development of Gamma Knife radiosurgery are described. After his retirement from Karolinska, Dr. Steiner had a second career as head of the Lars Leksell Gamma Knife Center at the University of Virginia in Charlottesville. The authors recall their own long association with Dr. Steiner and celebrate his contributions to the field of neurosurgery.

Report on visit from Prof. Kim Lutzen: Friday, 6 November 1998, Korolinska Institute (dept of nursing Stockholm, Sweden

Directory of Open Access Journals (Sweden)

Kim Lutzen

1999-10-01

Full Text Available Prof. Kim Lutzen contacted the Department of Advanced Nursing Sciences, Unisa, via the Department's Web Page. Prof. Lutzen is the Chair of the Department of Nursing, which offers undergraduate, master and doctoral programmes. This Department of Nursing is situated within the Karolinska Institute, which comprises 29 Departments of Health Sciences, including a number of Medical Departments, Dentistry, Occupational Therapy, Physiotherapy, and Nursing. Prof. Lutzen emphasised that there is no Swedish phrase similar to "nursing science", consequently this t e n seems to be somewhat unfamiliar to the Swedish nurses. *Please note: This is a reduced version of the abstract. Please refer to PDF for full text.

Improved survival after an educational project on colon cancer management in the county of Stockholm--a population based cohort study.

Science.gov (United States)

Bernhoff, R; Martling, A; Sjövall, A; Granath, F; Hohenberger, W; Holm, T

2015-11-01

Outcomes in rectal cancer have improved dramatically after the introduction of total mesorectal excision (TME). Recently, the TME concept has been transformed into that of complete mesocolic excision (CME) in an attempt to improve prognosis for patients with colon cancer. Multidisciplinary team (MDT) workshops including the CME concept were held annually between 2004 and 2008 at the Karolinska University Hospital. The workshops focused on preoperative staging, surgery and histopathology and included lectures and live surgery sessions. To compare survival before and after the "Stockholm Colon Cancer Project" all patients diagnosed with a right sided colon cancer between January 1, 2001 and December 31, 2003 (Group 1) and from January 1, 2006 until December 31, 2008 (Group 2) in Stockholm were identified from the Swedish ColoRectal Cancer Registry (SCRCR). The proportion of patients having a tumour resection and the proportion having emergency surgery was higher in Group 1. There were more early tumours and more R0 resections in Group 2. Overall survival in all diagnosed patients and disease free survival after tumour resection was improved in the second time period. Surgical teaching programmes may have an impact on the management and outcome in colon cancer. The exact impact from the "Stockholm Colon Cancer Project" cannot be established, however it is likely that it contributed to the improved survival. Copyright © 2015 Elsevier Ltd. All rights reserved.

The control of nuclear proliferation: future challenges. Swedish Institute of International Affairs, Stockholm, 23 April 1998

International Nuclear Information System (INIS)

ElBaradei, M.

1998-01-01

The document reproduces the text of the conference given by the Director General of the IAEA at the Swedish Institute of International Affairs in Stockholm on 23 April 1998. After a short presentation of the Agency's current verification activities, particularly in Iraq and Democratic People's Republic of Korea, the Director General focuses on the present and future role of the IAEA in the control of nuclear proliferation through its strengthened safeguards system, in the prevention of nuclear terrorism, and future challenges of controlling nuclear proliferation from both political and technical point of view

Mechanical thrombectomy in acute ischemic stroke: Consensus statement by ESO-Karolinska Stroke Update 2014/2015, supported by ESO, ESMINT, ESNR and EAN.

Science.gov (United States)

Wahlgren, Nils; Moreira, Tiago; Michel, Patrik; Steiner, Thorsten; Jansen, Olav; Cognard, Christophe; Mattle, Heinrich P; van Zwam, Wim; Holmin, Staffan; Tatlisumak, Turgut; Petersson, Jesper; Caso, Valeria; Hacke, Werner; Mazighi, Mikael; Arnold, Marcel; Fischer, Urs; Szikora, Istvan; Pierot, Laurent; Fiehler, Jens; Gralla, Jan; Fazekas, Franz; Lees, Kennedy R

2016-01-01

The original version of this consensus statement on mechanical thrombectomy was approved at the European Stroke Organisation (ESO)-Karolinska Stroke Update conference in Stockholm, 16-18 November 2014. The statement has later, during 2015, been updated with new clinical trials data in accordance with a decision made at the conference. Revisions have been made at a face-to-face meeting during the ESO Winter School in Berne in February, through email exchanges and the final version has then been approved by each society. The recommendations are identical to the original version with evidence level upgraded by 20 February 2015 and confirmed by 15 May 2015. The purpose of the ESO-Karolinska Stroke Update meetings is to provide updates on recent stroke therapy research and to discuss how the results may be implemented into clinical routine. Selected topics are discussed at consensus sessions, for which a consensus statement is prepared and discussed by the participants at the meeting. The statements are advisory to the ESO guidelines committee. This consensus statement includes recommendations on mechanical thrombectomy after acute stroke. The statement is supported by ESO, European Society of Minimally Invasive Neurological Therapy (ESMINT), European Society of Neuroradiology (ESNR), and European Academy of Neurology (EAN). © 2016 World Stroke Organization.

EMS – Elektron Musik Studion in Stockholm

DEFF Research Database (Denmark)

Groth, Sanne Krogh

2016-01-01

In 1964 the electronic music studio EMS, Stockholm opened as a conventional analogue studio. The primary intension with the institution was to build the world’s most advanced hybrid studio and to conduct an international research program into sound and sound perception. With financial support from...

A Novel Approach to Detect Therapeutic Resistance in Breast Cancer

Science.gov (United States)

2008-09-01

Resistance in Breast Cancer PRINCIPAL INVESTIGATOR: Kamila Czene, Ph.D. CONTRACTING ORGANIZATION: Karolinska Institutet ...ORGANIZATION REPORT NUMBER Karolinska Institutet Stockholm, Sweden 9. SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10...analysis. The digital image analysis algorithms and software that have been developed at Karolinska Institutet consists of an optimized combination of

The Stockholm declaration

International Nuclear Information System (INIS)

1988-03-01

The Stockholm Declaration was adopted on 21 January 1988 in Stockholm by the President of Argentina, the Prime Minister of Greece, the Prime Minister of India, the President of Mexico, the Prime Minister of Sweden and the President of the United Republic of Tanzania and it expresses the position of these states concerning nuclear disarmament

The Stockholm Festival, 1966

DEFF Research Database (Denmark)

Groth, Sanne Krogh

2013-01-01

The article is an introduction to the festival 'Visioner av Nuet' Stockholm, 1966. The article focuses on the historical event, and contextualizes it to both the discussions on art and technology at the time, and to the planned collaborations with the prominent artists from the American group E.......A.T. such as Billy Klüver, John Cage, Robert Rauchenberg and Öyvind Fahlström, - collaborations that never were succeeded. The article was written on a request from Anna Lundh and published in the catalogue for her reactualization of 'Visioner av Nuet, Stockholm Festival for Art and Technology', Stockholm 2013....

A Population-Based Study of Dietary Acrylamide and Prostate Cancer Risk

Science.gov (United States)

2007-06-01

7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBER Karolinska Institutet SE-171 77 Stockholm...life of red blood cells. The blood samples were pulled from the BioRepository at the Karolinska Institutet , and set for analysis at the laboratory of Dr...Acrylamide and Prostate Cancer Risk PRINCIPLE INVESTIGATOR: Hans-Olov Adami, M.D., Ph.D. CONTRACTING ORGANIZATION: Karolinska

Erik Gunnar Asplund’s Stockholm Public Library

DEFF Research Database (Denmark)

Andersen, Michael Asgaard

2017-01-01

Stockholm Public Library, which opened on March 31, 1928, was in many ways an innovation in the Nordic countries. Most striking was the fact that lenders could now take books off the shelves themselves, but the central placement of the lending room and the secondary placement of the reading rooms...... also indicated a new way to do libraries. The thoughts embodied in the building became a model for many later libraries. The building is not only testimony to an important period of Nordic architectural history and a recognized masterpiece by the Swedish architect Erik Gunnar Asplund (1885......–1940), it is also part of the history of the Nordic social model that was taking shape in the interwar years. By its function as a public institution and its unique architectural qualities, Stockholm Public Library today stands as an important work of Nordic welfare building....

Why is intravenous chemotherapy cancelled and how often. Could it be prevented? A prospective analysis of all planned and given intravenous anti-tumor treatments at the Department of Oncology, Karolinska University Hospital, Stockholm during one month.

Science.gov (United States)

Fuentes, Stina; Frödin, Jan-Erik

2015-07-01

Chemotherapy and targeted drugs are important tools in the treatment of malignant diseases. A number of the planned treatments are cancelled late which is a great challenge for the clinic to minimize in order to prevent the risk for misused resources. The aim of this study was to analyze the frequency and reasons for late (Karolinska University Hospital. The survey comprehends the vast majority of all such treatment for solid tumors in adult patients in the Stockholm region with two million inhabitants. All bookings and late cancellations including their reasons were recorded. Diagnoses, treatment indication, line of treatment and survival, in particular short term survival, were analyzed. Almost 3000 bookings for 1460 patients were included and 13% were cancelled late. Patient detoriation was the dominating cause for late cancellation in patients with palliative treatment (59%), while hematological toxicity was most common in the adjuvant group (42%). The most common treatment indication was palliative (62%). Of the palliative treatments, 95% where given in the first to third treatment line. Breast cancer (31.9%) and colorectal cancer (29.9%) were the two most common diagnoses. Seventy-one patients (4.9%) died within two months after the treatment. A more careful selection and monitoring of the patients might reduce the number of late cancellations due to patient detoriation. To record performance status (PS) as a routine for all patients might be helpful in that process. If the number of late cancellations could be reduced, resources at the clinic could be used more efficiently.

Validation of Karolinska Exhaustion Scale: psychometric properties of a measure of exhaustion syndrome.

Science.gov (United States)

Saboonchi, Fredrik; Perski, Aleksander; Grossi, Giorgio

2013-12-01

The syndrome of exhaustion is currently a medical diagnosis in Sweden. The description of the syndrome largely corresponds to the suggested core component of burnout, that is exhaustion. Karolinska Exhaustion Scale (KES) has been constructed to provide specific assessment of exhaustion in clinical and research settings. The purpose of the present study was to examine the psychometric properties of this scale in its original and revised versions by examining the factorial structure and measures of convergent and discriminant validity. Data gathered from two independent samples (n1 = 358 & n2 = 403) consisting of patients diagnosed with 'reaction to severe stress, and adjustment disorder' were subjected to confirmatory factor analysis. The study's instruments were Karolinska Exhaustion Scale and Shirom Melam Burnout Measure. Correlation analyses were employed to follow up the established factorial structure of the scale. The study was ethically approved by Karolinska Institute regional ethic committee. The findings demonstrated adequate fit of the data to the measurement model provided by the revised version of KES Limitations: The main limitation of the present study is the lack of a gold standard of exhaustion for direct comparison with KES. (KES-26) and partially supported convergent validity and discriminant validity of the scale. The demonstrated psychometric properties of KES-26 indicate sound construct validity for this scale encouraging use of this scale in assessment of exhaustion. The factorial structure of KES-26 may also be used to provide information concerning possible different clinical profiles. © 2012 The Authors Scandinavian Journal of Caring Sciences © 2012 Nordic College of Caring Science.

Stockholm revisited

Energy Technology Data Exchange (ETDEWEB)

Anon.

1985-03-15

The Nobel Physics Prize for 1984 was shared by Carlo Rubbia and Simon van der Meer of CERN for their decisive contributions to the project which led to the discovery of the W and Z field particles which carry the weak interaction. Five years before, Sheldon Glashow, Abdus Salam and Steven Weinberg had made the same trip to receive the prize for their crucial roles in piecing together the elegant 'electroweak' gauge theory which unified weak interactions with the electromagnetic force and predicted just where the W and Z particles could be found. In December, the three theorists returned to Stockholm to participate with the 1984 laureates in a specially arranged panel discussion for Stockholm students.

Stockholm revisited

International Nuclear Information System (INIS)

Anon.

1985-01-01

The Nobel Physics Prize for 1984 was shared by Carlo Rubbia and Simon van der Meer of CERN for their decisive contributions to the project which led to the discovery of the W and Z field particles which carry the weak interaction. Five years before, Sheldon Glashow, Abdus Salam and Steven Weinberg had made the same trip to receive the prize for their crucial roles in piecing together the elegant 'electroweak' gauge theory which unified weak interactions with the electromagnetic force and predicted just where the W and Z particles could be found. In December, the three theorists returned to Stockholm to participate with the 1984 laureates in a specially arranged panel discussion for Stockholm students

The sites and mechanisms of postoperative insulin resistance

OpenAIRE

Nygren, Jonas

1997-01-01

The Sites and Mechanisms of Postoperative InsulinResistance by Jonas Nygren, M.D. Departments of Surgery and Endocrinology and Diabetes, Karolinska Hospital and Institute, SE-171 76, Stockholm, Sweden In Sweden with nine million inhabitants, 450,000 operations(outpatients excluded) are performed every year resulting in2,250,000 treatment days in hospital. Surgical operations are part ofthe treatment for 44% of all patients admitted to hospital careoccupying 24% of all ...

Eating habits, weight reduction strategies and long-term treatment results in obese men : The "Gustaf" study

OpenAIRE

Andersson, Ingalena

1997-01-01

Eating habits, weight reduction strategies and long-term treatment resultsin obese men. The "Gustaf" study. Ingalena Andersson Obesity Unit and Health Behaviour Research, Department of Medicine, HuddingeHospital, Karolinska Institute, Stockholm, Sweden. Abdominal male obesity is associated with hypertension, abnormal blood lipidsand diabetes type 11. For development of a weight loss program for such males, 86obese men (BMI 37.7 [4.4] kg/m2) (mean [SD] ) from the wa...

The Use of Bibliographical Information Media by the Borrowers at the Karolinska Institutets Bibliotek (the Library of the Karolinska Institutet)

Science.gov (United States)

Hakulinen, Erkki

1974-01-01

A survey at the Karolinska Institutet Bibliotek in Sweden, and a comparison with an earlier survey at the National Lending Library, showed that conventional bibliographical information media are still responsible for the major part of information about biomedical literature. (Author/LS)

Transient Receptor Potential channels: What's happening? Reflections in the wake of the 2009 TRP Meeting, Karolinska Institutet, Stockholm.

Science.gov (United States)

Goswami, Chandan; Islam, Md Shahidul

2010-01-01

More than 150 participants from 25 countries gathered in Stockholm during 25(th) to 27(th) Sept 2009 to attend the meeting "TRP channels: from sensory signaling to human disease" and enjoyed an international, intensive and vibrant meeting. This meeting shed lights on the recent advances made in this field of research in different sectors of biology, and identified directions for future research and the areas where TRP channels could be used as potential targets for prevention and treatment of human diseases. The participants of this meeting shared their recent largely unpublished data, state-of-the-art techniques and their critical views which would push research in this field forward in the new decade. Another major outcome of this meeting was the realization that extensive work remains to be done to develop the necessary tools and enhance the quality of research in this area so that the prevailing controversies can be resolved. In this report we summarize the latest scientific excitements, some critical issues, as well as some future directions for research that were addressed and discussed in this meeting.

Intracavitary after loading techniques, advantages and disadvantages with high and low dose-rate methods

International Nuclear Information System (INIS)

Walstam, Rune

1980-01-01

Even though suggested as early as 1903, it is only when suitable sealed gamma sources became available, afterloading methods could be developed for interstitial as well as intracavitary work. Manual afterloading technique can be used only for low dose rate irradiation, while remote controlled afterloading technique can be used for both low and high dose-rate irradiation. Afterloading units used at the Karolinska Institute, Stockholm, are described, and experience of their use is narrated briefly. (M.G.B.)

Additive effects of nutritional supplementation, together with bisphosphonates, on bone mineral density after hip fracture: a 12-month randomized controlled study

Directory of Open Access Journals (Sweden)

Flodin L

2014-07-01

Full Text Available Lena Flodin,1,2 Maria Sääf,3 Tommy Cederholm,4 Amer N Al-Ani,2,5 Paul W Ackermann,5,6 Eva Samnegård,7 Nils Dalen,7 Margareta Hedström2,51Department of Geriatric Medicine, Karolinska University Hospital Stockholm, Sweden; 2Department of Clinical Science, Intervention, and Technology, Karolinska Institutet, Stockholm, Sweden; 3Department of Endocrinology, Metabolism, and Diabetes, Karolinska University Hospital, Stockholm, Sweden; 4Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden; 5Department of Orthopedics, Karolinska University Hospital, Stockholm, Sweden; 6Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; 7Department of Clinical Science, Division of Orthopedics, Karolinska Institutet, Danderyd Hospital, Stockholm, SwedenBackground: After a hip fracture, a catabolic state develops, with increased bone loss during the first year. The aim of this study was to evaluate the effects of postoperative treatment with calcium, vitamin D, and bisphosphonates (alone or together with nutritional supplementation on total hip and total body bone mineral density (BMD.Methods: Seventy-nine patients (56 women, with a mean age of 79 years (range, 61–96 years and with a recent hip fracture, who were ambulatory before fracture and without severe cognitive impairment, were included. Patients were randomized to treatment with bisphosphonates (risedronate 35 mg weekly for 12 months (B; n=28, treatment with bisphosphonates along with nutritional supplementation (40 g protein, 600 kcal daily for the first 6 months (BN; n=26, or to controls (C; n=25. All participants received calcium (1,000 mg and vitamin D3 (800 IU daily. Total hip and total body BMD were assessed with dual-energy X-ray absorptiometry at baseline, 6, and 12 months. Marker of bone resorption C-terminal telopeptide of collagen I and 25-hydroxy vitamin D were analyzed in serum

At crossroads between laboratory disciplines and medical advancements-The Center for Molecular Medicine at the Karolinska University Hospital.

Science.gov (United States)

Terenius, Lars

2009-04-01

The Center for Molecular Medicine (CMM) was conceived and built to respond to the challenges presented by the still common chronic diseases such as atherosclerosis, rheumatoid arthritis, diabetes, allergy, and alcoholism. The Karolinska University Hospital has a proud history of research with developments such as the pacemaker and the gamma-knife. The nearby Karolinska Institutet has a strong presence internationally on the basic sciences. However, the challenges of the "new biology" and the access to the complete human genome, transcriptome, and proteome raised the need for a new research institute that could meet the experimental requirements for translational research. A Foundation was established in 1994 with the goal to build and govern the new enterprise. After an intense fundraising campaign, building could start and CMM (Fig. 1) was inaugurated in 1997. Through more than 10 years of existence, it has evolved into a multidisciplinary research institute with research in four programs, Cardiovascular and Metabolic Diseases, Infection and Immunity, Neuropsychiatric Diseases, and Medical Genetics. Performance parameters have been introduced and scientific impact and relevance are followed annually. Transparency and collaboration between groups (now 28 groups with an approximate total of 400 people engaged in research) and leadership training for junior faculty are means to stimulate "centerness".

Sound of Stockholm

DEFF Research Database (Denmark)

Groth, Sanne Krogh

2013-01-01

Med sine kun 4 år bag sig er Sound of Stockholm relativt ny i det internationale festival-landskab. Festivalen er efter sigende udsprunget af en større eller mindre frustration over, at den svenske eksperimentelle musikscenes forskellige foreninger og organisationer gik hinanden bedene, og...

Construction and validation of the EEG analogues of the Karolinska sleepiness scale based on the Karolinska drowsiness test.

Science.gov (United States)

Putilov, Arcady A; Donskaya, Olga G

2013-07-01

Simple methods of sleepiness assessment are greatly needed for both fundamental research and practical applications. The Karolinska drowsiness test (KDT) was applied to construct physiological alertness scales and to validate them against such well-known instrument of subjective sleepiness assessment as the Karolinska sleepiness scale (KSS). Seven-min EEG recordings were obtained with 2-h interval from frontal and occipital derivations during the last 32-50 h of 44-61-h wakefulness of 15 healthy study participants. Occipital alpha-theta power difference and frontal and occipital scores on the 2nd principal component of the EEG spectrum were calculated for each one-min interval of 5-min eyes closed section of the record. To obtain scores (from 0 to 5) on alertness scales for each of these EEG indexes, all positive one-min values of the index were assigned to 1, and all remaining (negative) values were assigned to 0. Scores on any of the physiological alertness scales were found to be strongly associated with KSS scores. Physiological analogues of KSS were offered by utilising the EEG recordings on eyes closed interval of KDT. The constructed physiological scales can help in improving validity and user-friendliness of the field and laboratory methods of quantification of drowsy state. Copyright © 2013 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

KAMEDO report No. 93-the power failure at Karolinska University Hospital, Huddinge, 07 April 2007.

Science.gov (United States)

Angantyr, Lars-Göran; Häggström, Eskil; Kulling, Per

2009-01-01

A sudden and extensive power failure occurred at Karolinska University Hospital in Huddinge on Easter Saturday, 07 April 2007. The power failure lasted one hour and 22 minutes, but it took a longer time for activities to return to normal. It put many patients at great risk, particularly in the intensive care unit and other departments with critically ill patients. This report details the conditions and response at Karolinska University Hospital during the power failure and provides lessons learned for future events.

Development of light ion therapy at the Karolinska Hospital and Institute.

Science.gov (United States)

Svensson, Hans; Ringborg, Ulrik; Näslund, Ingemar; Brahme, Anders

2004-12-01

Recent developments in radiation therapy have made it possible to optimize the high dose region to cover almost any target volume and shape at the same time as the dose level to adjacent organs at risk is acceptable. Further implementations of IMRT (Intensity Modulated Radiation Therapy), and inverse treatment planning using already available technologies but also foreseeable improved design of therapy accelerators delivering electron- and photon beams, will bring these advances to the benefit of a broad population of cancer patients. Protons will therefore generally not be needed since in most situations the improvement will be insignificant or moderate due to the large lateral penumbra with deep proton therapy. A further step would be to use He-ions, which have only half the penumbra width of protons and still a fairly low-LET in the spread-out Bragg peak. There is however still a group of patients that cannot be helped by these advances as the tumor might be radioresistant for the presently utilized low ionization density beam qualities. The ultimate step in the therapy development process should therefore be to optimize the beam quality for each tumor-normal tissue situation. To facilitate beam quality optimization light ions are needed. It is argued that in many radioresistant tumors a dose-mean LET of 25-50 eV/nm in the target would be optimum as then tumor cells will be lost in the highest proportion through apoptotic cell kill and the superficial tissues will still be irradiated with a fairly low LET. Light ions using Li, Be, B, and C would then be the ideal choice. In this paper a light ion facility is outlined for the Karolinska University Hospital facilitating both dose distribution and beam quality optimization.

Impressions from the ATLAS Overview Week in Stockholm

CERN Document Server

De Jong, P.; Gowdy, S.

2006-01-01

Paul de Jong: "What a very nice city Stockholm in the summer turned out to be! The architecture, the relaxed style of the city and its islands and bridges, the terraces with people out on the streets until late at night made this a special trip. We visited many cool and trendy places, unfortunately many of those places are probably now a lot less cool and trendy after visits of so many physicists in shorts and white socks in sandals. A big applause for the organizers for a fine meeting, and getting us into the Stockholm city hall and the superb Wasa museum. (left) The Golden room of Stockholm City Hall. (right) Muriel was not the only one in the room entertaining noble dreams during the reception in the Golden Room of the Stockholm City Hall... ATLAS is a monstrously complicated piece of apparatus. It will be very impressive when it is finished and works, but there are so many places where things can go wrong. If I must name a single highlight of the week: I found the technical coordination of t...

Letter from Stockholm.

Science.gov (United States)

Johansson, Per Magnus

2015-04-01

Some of the ideas of Sigmund Freud were preceded in a literary form by the Swedish writer August Strindberg in the late 19th century. Psychoanalysis itself was introduced in Sweden about a decade into the 20th century by two rivalling pioneers, the doctors Emanuel af Geijerstam and Poul Bjerre. After a slow start, the Danish-Norwegian Psychoanalytical Society and the Finnish-Swedish Psychoanalytical Society were formed in 1934 in Stockholm. The same year, Ericastiftelsen [The Erica Foundation], a psychotherapeutic clinic for children, was founded by Hanna Bratt. Five years later, in 1939, also in Stockholm, the organization that was to become St. Lukasstiftelsen [The Saint Luke's Foundation] was founded. It has been, and still is, an association that has trained psychodynamic psychotherapists, with a focus on existential, religious and philosophical questions. Today, St. Luke's tries to be up-dated from an academic standpoint. During the Second World War, several important psychoanalysts came to Sweden, for example René de Monchy, Lajos and Edith Székely, and Stefi Pedersen. Ola Andersson's doctoral dissertation ("Studies in the Prehistory of Psychoanalysis", 1962) and the historian Gunnar Brandell's essay ("Freud, a Man of His Century", 1961) have had an international impact. In the last two decades, an authorized and carefully edited translation of Freud's collected works has been published by Natur och Kultur, and the history of psychoanalysis in Sweden has been written at the University of Gothenburg. As a result of a recent interest in the work of Jacques Lacan, and French psychoanalysis, philosophy and literature, the journal Psykoanalytisk Tid/Skrift was founded in 2002, in Gothenburg. Since 2011 the journal is called Arche. The largest organized group of psychoanalysts in Sweden today is the Swedish Psychoanalytical Association (SPAF), which has around 225 members. Since 2008, it no longer has the right to license psychotherapists, a situation which

Validation of the Karolinska sleepiness scale against performance and EEG variables.

Science.gov (United States)

Kaida, Kosuke; Takahashi, Masaya; Akerstedt, Torbjörn; Nakata, Akinori; Otsuka, Yasumasa; Haratani, Takashi; Fukasawa, Kenji

2006-07-01

The Karolinska sleepiness scale (KSS) is frequently used for evaluating subjective sleepiness. The main aim of the present study was to investigate the validity and reliability of the KSS with electroencephalographic, behavioral and other subjective indicators of sleepiness. Participants were 16 healthy females aged 33-43 (38.1+/-2.68) years. The experiment involved 8 measurement sessions per day for 3 consecutive days. Each session contained the psychomotor vigilance task (PVT), the Karolinska drowsiness test (KDT-EEG alpha & theta power), the alpha attenuation test (AAT-alpha power ratio open/closed eyes) and the KSS. Median reaction time, number of lapses, alpha and theta power density and the alpha attenuation coefficients (AAC) showed highly significant increase with increasing KSS. The same variables were also significantly correlated with KSS, with a mean value for lapses (r=0.56). The KSS was closely related to EEG and behavioral variables, indicating a high validity in measuring sleepiness. KSS ratings may be a useful proxy for EEG or behavioral indicators of sleepiness.

Affective psychotherapy in post-traumatic reactions guided by affective neuroscience: memory reconsolidation and play

Directory of Open Access Journals (Sweden)

Högberg G

2011-07-01

Full Text Available Göran Högberg1,2, Davide Nardo3, Tore Hällström4,5, Marco Pagani6,71Department of Women's and Children's Health, Child and Adolescent Psychiatric Unit, Astrid Lindgren Children's Hospital, Karolinska Institutet, Stockholm, Sweden; 2BUP Huddinge Child and Adolescent Psychiatry, Stockholm, Sweden; 3Neuroimaging Laboratory, Santa Lucia Foundation, Rome, Italy; 4Department of Clinical Neuroscience, Section for Psychiatry/Huddinge, Karolinska Institutet, Stockholm, Sweden; 5Department of Neuroscience, Section of Psychiatry and Neurochemistry, Unit for Neuropsychiatric Epidemiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; 6Department of Nuclear Medicine, Karolinska Hospital, Stockholm, Sweden; 7Institute of Cognitive Sciences and Technologies, CNR, Rome, ItalyAbstract: This paper reviews the affective neuroscience dealing with the effects of traumatic events. We give an overview of the normal fear reactions, the pathological fear reaction, and the character of emotional episodic memories. We find that both emotions and emotional memories are a tripartite unit of sensory information, autonomic reaction, and motor impulse (the PRM complex. We propose that emotions and movements are part and parcel of the same complex. This is our main finding from the review of affective neuroscience, and from here we focus on psychotherapy with post-trauma reactions. The finding of the process of memory reconsolidation opens up a new treatment approach: affective psychotherapy focused on reconsolidation. The meaning of reconsolidation is that an emotional memory, when retrieved and being active, will rest in a labile form, amenable to change, for a brief period of time, until it reconsolidates in the memory. This leads us to the conclusion that emotions, affects, must be evoked during the treatment session and that positive emotion must come first, because safety must be part of the new memories. In the proposed protocol of affective

Levels of Antiepileptic Drugs and the Ketogenic Diet

Directory of Open Access Journals (Sweden)

J Gordon Millichap

2006-08-01

Full Text Available Introduction of the ketogenic diet did not change the plasma levels of antiepileptic drugs in an open study of 51 children (mean age 6.6 years with refractory epilepsy studied at Karolinska University Hospital, Stockholm, Sweden.

Soome kindlus Stockholmis : Soome Suursaatkond = Finnish Stronghold in Stockholm : Finnish Embassy in Stockholm / Kristian Gullichsen

Index Scriptorium Estoniae

Gullichsen, Kristian

2004-01-01

Soome suursaatkonna (Gärdesgatan, Stockholm) projekteeris büroo Gullichsen Kairamo Arkkidehdit. Autorid Kristian Gullichsen, Jyri Haukkavaara, sisekujundaja Aulikki Jylhä. Projekt 1996, valmis 2002. I ja II korruse plaan, 4 sise- ja 4 välisvaadet

Cues of fatigue: effects of sleep deprivation on facial appearance

NARCIS (Netherlands)

Sundelin, T.; Lekander, M.; Kecklund, G.; van Someren, E.J.W.; Olsson, A.; Axelsson, J.

2013-01-01

Study Objective: To investigate the facial cues by which one recognizes that someone is sleep deprived versus not sleep deprived. Design: Experimental laboratory study. Setting: Karolinska Institutet, Stockholm, Sweden. Participants: Forty observers (20 women, mean age 25 ± 5 y) rated 20 facial

Using the Karolinska Scales of Personality on male juvenile delinquents: relationships between scales and factor structure.

Science.gov (United States)

Dåderman, Anna M; Hellström, Ake; Wennberg, Peter; Törestad, Bertil

2005-01-01

The aim of the present study was to investigate relationships between scales from the Karolinska Scales of Personality (KSP) and the factor structure of the KSP in a sample of male juvenile delinquents. The KSP was administered to a group of male juvenile delinquents (n=55, mean age 17 years; standard deviation=1.2) from four Swedish national correctional institutions for serious offenders. As expected, the KSP showed appropriate correlations between the scales. Factor analysis (maximum likelihood) arrived at a four-factor solution in this sample, which is in line with previous research performed in a non-clinical sample of Swedish males. More research is needed in a somewhat larger sample of juvenile delinquents in order to confirm the present results regarding the factor solution.

Research Article (Human Resources for Health) Postoperative ...

African Journals Online (AJOL)

2007-06-14

Jun 14, 2007 ... ... of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden. 4. ... six year Emergency Human Resource Programme aimed ... therefore to elucidate the extent of major surgical work ... back for review seven days after discharge. ... and 24 hour maternal condition, post-operative fever, wound.

Stockholm Shines (Editorial

Directory of Open Access Journals (Sweden)

Denise Koufogiannakis

2009-09-01

a good turnout for our user group, and a lively discussion. People told us what they valued about the journal, with much discussion focused on the evidence summaries. The evidence summaries are valued as a unique way to learn more about original research, and a few people noted that they will show evidence summaries to senior managers when the summary focuses on an aspect of practice that is being considered at their institution. One thing that came up time and time again was how to get more international content into the journal. As a result, we are going to try to incorporate reviews of non‐English language research. We also actively encourage people from anywhere in the world to submit articles or volunteer to serve on our Editorial Advisory Board or in some other capacity. The user group session was over before we knew it, but as always, I encourage all readers to provide us with feedback about how we can make EBLIP better.In this issue, there are a couple of things from the conference that I want to highlight. Andrew Booth proposes an International Association of EBLIP in a commentary; this was the result of an early morning open meeting held during the conference. As well, several conference attendees have provided reflections on their experiences, which you will find in the News section. For those who could not attend in person, this will give you a good sense of what happened at the conference from different perspectives. And finally, the first of what we hope are many papers resulting from presentations given at EBLIP5, an article by Michael Raynor is available in this issue. In a future issue we will have a Feature focused on all the keynote presentations that were given in Stockholm. As the days grow short here in my part of the world, I look back fondly on the long days in Stockholm this past summer, and am inspired to keep contributing to this international EBLIP community that continues to question our own models of practice in an effort to serve our

Interface management of pharmacotherapy. Joint hospital and primary care drug recommendations.

Science.gov (United States)

Björkhem-Bergman, Linda; Andersén-Karlsson, Eva; Laing, Richard; Diogene, Eduardo; Melien, Oyvind; Jirlow, Malena; Malmström, Rickard E; Vogler, Sabine; Godman, Brian; Gustafsson, Lars L

2013-05-01

In September 2012 an interactive course on the "Interface Management of Pharmacotherapy" was organized by the Stockholm Drug and Therapeutics Committee in cooperation with Department of Clinical Pharmacology at Karolinska Institutet and at Karolinska University Hospital in Stockholm, Sweden, in collaboration with the WHO. The basis for the course was the "Stockholm model" for the rational use of medicines but also contained presentations about successful models in interface management of pharmacotherapy in other European countries. The "Stockholm model" consists of 8 components: 1) Independent Drug and Therapeutics Committee with key role for respected drug experts with policy for "interest of conflicts", 2) The "Wise List", recommendations of medicines jointly for primary and hospital care, 3) Communication strategy with continuous medical education, 4) Systematic introduction of new expensive medicines, 5) E-pharmacological support at "point of care", 6) Methods and tools for follow-up of medicines use, 7) Medicines policy strategy and 8) Operative resources. The course highlighted the importance of efficient and targeted communication of drug recommendations building on trust among prescribers and patients for the guidelines to achieve high adherence. Trust is achieved by independent Drug and Therapeutics Committees with a key role for respected experts and a strict policy for "conflicts of interest". Representations of GPs are also crucial for successful implementation, being the link between evidence based medicine and practice. The successful models in Scotland and in Stockholm as well as the ongoing work in Catalonia were considered as examples of multifaceted approaches to improve the quality of medicine use across primary and hospital care.

Incidence of lung cancer among subway drivers in Stockholm.

Science.gov (United States)

Gustavsson, Per; Bigert, Carolina; Pollán, Marina

2008-07-01

Very high levels of airborne particles have been detected in the subway system in Stockholm. Subway particles are more toxic to DNA in cultured human lung cells than particles from ambient air. This cohort comprised all men in Stockholm County who were gainfully employed in 1970. They were followed for cancer incidence until 1989. Lung cancer cases were identified from the national cancer register. Subway drivers were identified from the census in 1970. The reference cohort comprised all transport and communication workers in Stockholm. There were nine cases of lung cancer among the subway drivers, giving a SIR of 0.82 (95% confidence interval 0.38-1.56). The lung cancer incidence was not increased among the subway drivers. The study gives some evidence against the hypothesis that subway particles would be more potent in inducing lung cancer than particles in ambient air. (c) 2008 Wiley-Liss, Inc.

Management of intracranial hemorrhage in adult patients on extracorporeal membrane oxygenation (ECMO)

DEFF Research Database (Denmark)

Fletcher-Sandersjöö, Alexander; Thelin, Eric Peter; Bartek, Jiri

2017-01-01

: We conducted a retrospective review of adult patients (≥18 years) who developed an ICH during ECMO treatment at the Karolinska University Hospital (Stockholm, Sweden) between September 2005 and May 2017. Outcome was assessed by 30-day mortality and Glasgow Outcome Scale (GOS) after 6 months...

Biological Cell Identification by Integrating Micro-Fluidics, Electrical Impedance Spectroscopy and Stochastic Estimation

Science.gov (United States)

2007-03-01

Karolinska Institutet in Stockholm entitled "Skin Cancer as Seen by Electrical Impedance" [1]. The thesis describes Åberg�s experiments to detect skin cancer...ska Institutet , 2004. 2. Ayli¤e, H. Edward, et al. �Electric Impedance Spectroscopy Using Microchannels with Integrated Metal Electrodes

Exchange program. Alternative options for purchase of environmentally friendly vehicles in Stockholm

Energy Technology Data Exchange (ETDEWEB)

Rader Olsson, Amy [Inregia AB, Stockholm (Sweden); Elam, N. [Atrax Energi AB, Goeteborg (Sweden)

1999-11-01

The city of Stockholm has decided to exchange 300 of its gasoline-driven vehicles for vehicles which emit fewer hazardous pollutants. A vehicle exchange program is being developed based on analyses which describe the driving patterns of Stockholm's vehicles, alternative fuel technology status, and financing alternatives. This report comprises the first two analyses, that of Stockholm's fleet driving patterns and alternative fuel technology options. The report has four major sections: * a technical analysis of the status of certain fuels and vehicles, including prognoses of availability in Sweden and the future development potential of each. (electric, biogas, ethanol, RME), * a driving study, which identifies those vehicles currently in Stockholm's fleet which could be exchanged for alternatively-fueled vehicles, * an analysis of five purchase package alternatives, and * a location analysis, which describes the accessibility of vehicles in each alternative to alternative fuel refueling facilities in Stockholm. Given current prices and availability of the alternative fuels and vehicles studied, we recommend a high share of electric and biogas vehicles for purchases during 1997. The cost-effectiveness of different vehicle types in their reduction of various hazardous pollutants, may however change dramatically as prices and availability of vehicles changes and the market for alternative fuels develops. Accessibility to alternative fuel refueling facilities is adequate in Stockholm, though not always ideal. To improve the accessibility of biogas vehicles further, we suggest a third biogas refueling facility in the city's northeastern area (Ropsten, Vaertahamnen). If MFO chooses to purchase a significant number of diesel passenger vehicles to be driven on RME; we propose that a facility in the northeastern area would improve accessibility more than another facility in southern Stockholm.

The PATT 26 conference Stockholm, Sweden 26–30 June 2012 : Technology Education in the 21st Century

OpenAIRE

2012-01-01

PATT 26 will be held at the Royal Institute of Technology (KTH) in Stockholm, the beautiful capital of Sweden. The PATT 26 conference is part of a two-conference arrangement organized by the Royal Institute of Technology and the Centre for School Technology Education, CETIS, Linköping University, under the common heading Technology Education in the 21st Century. We hereby welcome international colleagues to this golden opportunity to share and learn more about the latest on-going and complete...

Predictors of intracranial hemorrhage in adult patients on extracorporeal membrane oxygenation

DEFF Research Database (Denmark)

Fletcher Sandersjöö, Alexander; Bartek, Jiri; Thelin, Eric Peter

2017-01-01

was to identify predictors of ICH in ECMO-treated adult patients. METHODS: We conducted a retrospective review of adult patients (≥18 years) treated with ECMO at the Karolinska University Hospital (Stockholm, Sweden) between September 2005 and June 2016, excluding patients with ICH upon admission or those who...

Relationships between Karolinska Personality Scales and the new factors and facets of the Zuckerman-Kuhlman-Aluja Personality Questionnaire (Relaciones entre las Escalas de Personalidad Karolinska y los nuevos factores y facetas del Cuestionario de Personalidad de ZuckermanKuhlman-Aluja

Directory of Open Access Journals (Sweden)

Sergio Escorial

2015-12-01

Full Text Available Psychobiological models of personality are of great use in clinical and research settings given their potential to construct working hypotheses on biological and behavioural correlates, as well as to predict vulnerability to mental disorders. Two personality models are rooted in this psychobiological tradition: Zuckerman`s Alternative Five Factors and the Karolinska Personality Scales (KSP. A new instrument (ZKA-PQ has been recently developed by Aluja, Kuhlman & Zuckerman (2010 to measure the Alternative Five Factors. The ZKA-PQ incorporates four new facets by each trait. This article analyses areas of overlap and differences between the ZKA-PQ and Karolinska Personality Scales. The total sample comprised 584 subjects (294 men and 290 women. The results suggest that sensation seeking (ZKA-PQ is mainly associated with monotony avoidance (KSP, neuroticism (ZKA-PQ with anxiety scales, aggressiveness (ZKAPQ with every KSP aggression scale, and extroversion (ZKA-PQ with the detachment scale (KSP. The discussion mainly centres on the information provided by the ZKA-PQ facets beyond basic personality traits, since in certain cases they qualify these general patterns, adding relevant information on the nature of the ZKA-PQ and Karolinska scales.

Renovation of the Stockholm sewerage system

International Nuclear Information System (INIS)

Sandin, Paer

1987-01-01

Within a few years Stockholm will let all its treated wastewater into the Saltsjoen. The Saltsjoen is the inner part of the Stockholm Archipelago, which is one of the finest recreation areas in Sweden and where many Stockholmians spend a great deal of their leisure time. That is one reason why it is so important that all wastewater is treated before it reaches the recipient. A sewerage system in bad condition means that the risk of not allowed/unplanned overflows is increased. In order to prevent overflows we drafted 'Plan 83' which tells us how our sewerage system shall be constructed in the future and what measures has to be made in the system. Renovations of the existing pipes is one method to get a well functioning sewer system. Today we have made about 50 different objects at a total length of 6000 m. Why do we renovate sewers and why are we attempting to develop methods for pipe renovations?

In memoriam Ladislau Steiner, neurosurgeon: some people from transylvania do live forever.

Science.gov (United States)

Dinca, Eduard B; Ciurea, Alexandru V; Valéry, Charles-Ambroise

2014-01-01

We review the extraordinary professional trajectory of Ladislau Steiner, a prolific neurosurgeon and radiosurgeon, who died earlier this year. Dr. Steiner trained and practiced as a neurosurgeon in his native Romania until he was 42, before moving to Stockholm. After 25 years at the Karolinska Institute, when most people consider retirement, he spent the following 25 years of his life as director of the Lars Leksell Center for Gamma Knife Radiosurgery at the University of Virginia, Charlottesville, Virginia. At 90, nostalgia for Europe made him accept the position of director of the Gamma Knife Center at the International Neuroscience Institute in Hannover, Germany. His life was dedicated to the 15,000 patients whose lives he saved in his lengthy career. Copyright © 2014 Elsevier Inc. All rights reserved.

Incentives for environmentally friendly vehicles. A report from the Environment and Health Protection Administration in Stockholm

Energy Technology Data Exchange (ETDEWEB)

Henriksson, Cecilia; Paedam, S. [Inregia AB, Stockholm (Sweden)

1999-11-01

This report deals with incentives for environmentally friendly vehicles. The report includes a description of the current status of these vehicles in Sweden, Stockholm County Council, and the City of Stockholm. A forecast of possible development of zero and low emission vehicles is carried out. The major obstacles which currently hinder a market for these vehicles are noted. In order to determine market readiness and factors which affect these firms' purchase of vehicles, interviews were carried out with private firms. This analysis indicates that institutional barriers in Sweden hinder zero and low emission vehicles, with laws and tax policies which offer conflicting signals. To follow international developments, these obstacles must be reduced. Therefore, it is important that Stockholm works to create a positive climate for environmentally friendly vehicles. This means that it is important that the policies recommended in this report are implemented with adequate intensity. Because knowledge about zero and low emission vehicles is limited, there is a need to produce factual information. Information can be spread to a larger group, but it is more cost effective to reach a group which is most likely to accept environmentally friendly vehicles. This could include companies with environmental profiles, or those who drive and use company cars. To increase the effectiveness of this information campaign, we suggest that the City also maintain a demonstration fleet with loaner cars for companies who wish to test these vehicles in daily operation before deciding whether or not to purchase them. The incentive package recommended for Stockholm includes offering parking rebates to various groups who park in the city centre; residents , commercial vehicles, and temporary visitors. For equity reasons, all groups should in practice be offered the rebate. To increase the positive effect of the incentive, environmentally friendly vehicles should also be allowed to drive in

Stockholm CHP potential - An opportunity for CO2 reductions?

International Nuclear Information System (INIS)

Danestig, Maria; Gebremehdin, Alemayehu; Karlsson, Bjoern

2007-01-01

The potential for combined heat and power (CHP) generation in Stockholm is large and a total heat demand of about 10 TWh/year can be met in a renewed large district heating system. This model of the Stockholm district heating system shows that CHP generation can increase from 8% in 2004 to 15.5% of the total electricity generation in Sweden. Increased electricity costs in recent years have awakened an interest to invest in new electricity generation. Since renewable alternatives are favoured by green certificates, bio-fuelled CHP is most profitable at low electricity prices. Since heat demand in the district heating network sets the limit for possible electricity generation, a CHP alternative with a high electricity to heat ratio will be more profitable at when electricity prices are high. The efficient energy use in CHP has the potential to contribute to reductions in carbon dioxide emissions in Europe, when they are required and the European electricity market is working perfectly. The potential in Stockholm exceeds Sweden's undertakings under the Kyoto protocol and national reduction goals. (author)

The role of gender inequities in women's access to reproductive health care: a population-level study of Namibia, Kenya, Nepal, and India

Directory of Open Access Journals (Sweden)

Namasivayam A

2012-07-01

Full Text Available Amrita Namasivayam,1 Donatus C Osuorah,2 Rahman Syed,3 Diddy Antai3,41Department of Public Health, Division of Global Health (IHCAR, Karolinska Institute, Stockholm, Sweden; 2Department of Pediatrics, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra, Nigeria; 3Department of Public Health, Division of Social Medicine, Karolinska Institute, Stockholm, Sweden; 4Division of Global Health and Inequalities, The Angels Trust, Abuja, NigeriaBackground: The role of gender inequities in explaining women's access to reproductive health care was examined in four countries (two sub-Saharan African and two South Asian countries. The extent of gender inequities varies across and within countries, and is rooted in the different cultural practices and gender norms within these different countries, and differences in the status and autonomy of women.Methods: Demographic and Health Survey data from women aged 15–49 years within these countries were analyzed with multivariate logistic regression analysis to examine the role of multidimensional characteristics of gender inequities, operationalized as access to skilled antenatal care, tetanus toxoid injection during pregnancy, and access to skilled antenatal care.Results: Significant associations were found between several dimensions of gender inequities (with the exception of decision-making autonomy and reported use of maternal reproductive health care services. Several pathways of influence between the outcome and exposure variables were also identified.Conclusion: Dimensions of gender inequities (with the exception of decision-making autonomy differentially influenced woman's use of reproductive health care services, thus highlighting the urgent need for concerted and sustained efforts to change these harmful traditional values if several of these countries are to meet Millennium Development Goal-5.Keywords: women, gender inequities, reproductive health care, Namibia, Kenya, Nepal, India

Progranulin mutation causes frontotemporal dementia in the Swedish Karolinska family.

Science.gov (United States)

Chiang, Huei-Hsin; Rosvall, Lina; Brohede, Jesper; Axelman, Karin; Björk, Behnosh F; Nennesmo, Inger; Robins, Tiina; Graff, Caroline

2008-11-01

Frontotemporal dementia (FTD) is a neurodegenerative disease characterized by cognitive impairment, language dysfunction, and/or changes in personality. Recently it has been shown that progranulin (GRN) mutations can cause FTD as well as other neurodegenerative phenotypes. DNA from 30 family members, of whom seven were diagnosed with FTD, in the Karolinska family was available for GRN sequencing. Fibroblast cell mRNA from one affected family member and six control individuals was available for relative quantitative real-time polymerase chain reaction to investigate the effect of the mutation. Furthermore, the cDNA of an affected individual was sequenced. Clinical and neuropathologic findings of a previously undescribed family branch are presented. A frameshift mutation in GRN (g.102delC) was detected in all affected family members and absent in four unaffected family members older than 70 years. Real-time polymerase chain reaction data showed an approximately 50% reduction of GRN fibroblast mRNA in an affected individual. The mutated mRNA transcripts were undetectable by cDNA sequencing. Segregation and RNA analyses showed that the g.102delC mutation, previously reported, causes FTD in the Karolinska family. Our findings add further support to the significance of GRN in FTD etiology and the presence of modifying genes, which emphasize the need for further studies into the mechanisms of clinical heterogeneity. However, the results already call for attention to the complexity of predictive genetic testing of GRN mutations.

The 2-oxoglutarate analog 3-oxoglutarate decreases normoxic hypoxia-inducible factor-1α in cancer cells, induces cell death, and reduces tumor xenograft growth

Directory of Open Access Journals (Sweden)

Koivunen P

2016-03-01

Full Text Available Peppi Koivunen,1 Stuart M Fell,2,3 Wenyun Lu,4 Joshua D Rabinowitz,4 Andrew L Kung,5,6 Susanne Schlisio,2,7 1Biocenter Oulu, Faculty of Biochemistry and Molecular Medicine, Oulu Center for Cell-Matrix Research, University of Oulu, Oulu, Finland; 2Ludwig Institute for Cancer Research Ltd, Stockholm, Sweden; 3Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden; 4Department of Chemistry and Integrative Genomics, Princeton University, Princeton, NJ, 5Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, 6Department of Pediatrics, Columbia University Medical Center, New York, NY, USA; 7Department of Microbiology and Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden Abstract: The cellular response to hypoxia is primarily regulated by the hypoxia-inducible factors (HIFs. HIF-1α is also a major mediator of tumor physiology, and its abundance is correlated with therapeutic resistance in a broad range of cancers. Accumulation of HIF-1α under hypoxia is mainly controlled by the oxygen-sensing HIF prolyl 4-hydroxylases (EGLNs, also known as PHDs. Here, we identified a high level of normoxic HIF-1α protein in various cancer cell lines. EGLNs require oxygen and 2-oxoglutarate for enzymatic activity. We tested the ability of several cell-permeable 2-oxoglutarate analogs to regulate the abundance of HIF-1α protein. We identified 3-oxoglutarate as a potent regulator of HIF-1α in normoxic conditions. In contrast to 2-oxoglutarate, 3-oxoglutarate decreased the abundance of HIF-1α protein in several cancer cell lines in normoxia and diminished HIF-1α levels independent of EGLN enzymatic activity. Furthermore, we observed that 3-oxoglutarate was detrimental to cancer cell survival. We show that esterified 3-oxoglutarate, in combination with the cancer chemotherapeutic drug vincristine, induces apoptosis and inhibits tumor growth in vitro and in vivo. Our data

Ethical aspects of registry-based research in the Nordic countries

Directory of Open Access Journals (Sweden)

Ludvigsson JF

2015-11-01

Full Text Available Jonas F Ludvigsson,1,2 Siri E Håberg,3 Gun Peggy Knudsen,3 Pierre Lafolie,4,5 Helga Zoega,6 Catharina Sarkkola,7 Stephanie von Kraemer,7 Elisabete Weiderpass,1,7–10 Mette Nørgaard11 1Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, 2Department of Pediatrics, Örebro University Hospital, Örebro, Sweden; 3Norwegian Institute of Public Health, Oslo, Norway; 4Department of Medicine, Clinical Pharmacology Unit, 5The Stockholm Regional Ethical Review Board, Karolinska Institutet, Stockholm, Sweden; 6Center of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavík, Iceland; 7Genetic Epidemiology Group, Folkhälsan Research Center, Helsinki, Finland; 8Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, 9The Arctic University of Norway, Tromsø, 10Department of Research, Cancer Registry of Norway, Oslo, Norway; 11Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark Abstract: National health care registries in the Nordic countries share many attributes, but different legal and ethical frameworks represent a challenge to promoting effective joint research. Internationally, there is a lack of knowledge about how ethical matters are considered in Nordic registry-based research, and a lack of knowledge about how Nordic ethics committees operate and what is needed to obtain an approval. In this paper, we review ethical aspects of registry-based research, the legal framework, the role of ethics review boards in the Nordic countries, and the structure of the ethics application. We discuss the role of informed consent in registry-based research and how to safeguard the integrity of study participants, including vulnerable subjects and children. Our review also provides information on the different government agencies that contribute registry-based data, and a list of the major health registries in Denmark, Finland, Iceland, Norway, and

Molecular aspects in clinical hemostasis research at Karolinska Institutet.

Science.gov (United States)

Blombäck, Margareta

2010-05-21

The development of hemostasis research at Karolinska Institutet is described, focusing first on the initial findings of the fibrinogen structure and the hereditary bleeding disorders, hemophilia A and von Willebrand's disease. Basic research has focused on new biomarkers for cardiovascular/thromboembolic disorders, such as myocardial infarction and stroke, including preeclampsia and diabetes, with studies on the importance of decreased fibrinolysis in these disorders. Since long, the structure of the fibrin network has been evaluated, and recently the influence of aspirin and new thrombin and factor Xa inhibitors has been investigated. Research on the contact pathway of coagulation has also started at the Unit. 2010 Elsevier Inc. All rights reserved.

Substance Flow Analyses of Organic Pollutants in Stockholm

International Nuclear Information System (INIS)

Jonsson, A.; Friden, U.; Thuresson, K.; Soerme, L.

2008-01-01

This paper summarizes substance flow analyses for four organic substances in the City of Stockholm, Sweden: diethylhexyl phthalate (DEHP), alkylphenolethoxylates (APEO), polybrominated diphenylethers (PBDE) and chlorinated paraffins (CP). The results indicate that the stocks of APEO, PBDE and CP all are approximately 200-250 tonnes, whereas the DEHP stock is two orders of magnitude larger. Emissions can be linked to imported consumer goods such as electronics (PBDE) and textiles (APEO), and to construction materials (DEHP, CP). For several of the substances considerable amounts remain in the technosphere for a long time, even after use of the substance in new products has been eliminated. For example, the use of DEHP as plasticizer for PVC plastics in cables and floorings has more or less been phased-out, but still these applications make up a stock of some 20,000 tonnes (85% of the total DEHP stock in Stockholm) and emit 28 tonnes of DEHP annually (93% of overall emissions). Likewise, the use of chlorinated paraffins in sealants has been radically reduced, but there are 170 tonnes of CP in sealants in Stockholm making up 75% of the stock, and causing half of the emissions to water and air. These emissions are likely to continue for decades, and the stocks therefore have to be considered when analysing and managing the impact of urban substance flows on the environment

Sex effects on short-term complications after hip fracture: a prospective cohort study

Directory of Open Access Journals (Sweden)

Ekström W

2015-08-01

Full Text Available Wilhelmina Ekström,1 Bodil Samuelsson,2 Sari Ponzer,3 Tommy Cederholm,4,5 Karl-Göran Thorngren,6 Margareta Hedström7 1Department of Molecular Medicine and Surgery, Section of Orthopaedics and Sports Medicine, Karolinska Institutet, Karolinska University Hospital, Solna, 2Department of Clinical Sciences, Karolinska Institutet, Danderyd Hospital, 3Department of Clinical Science and Education, Section of Orthopaedics, Karolinska Institutet, Södersjukhuset, Stockholm, 4Department of Public Health and Caring Sciences, 5Department of Geriatrics, Uppsala University, Uppsala University Hospital, Uppsala, 6Department of Clinical Sciences, Lund, Orthopaedics, Lund University, Lund, 7Department of Orthopaedics, Institute of Clinical Science, Intervention and Technology (CLINTEC, Karolinska University Hospital, Huddinge, Stockholm, Sweden Objectives: To evaluate potential sex differences and other factors associated with complications within 4 months after a hip fracture.Methods: A total of 1,915 patients ≥65 years (480 men with hip fracture were consecutively included in a prospective multicenter cohort study. A review of medical records and patient interviews according to a study protocol based on the Standardized Audit of Hip Fractures in Europe (SAHFE, RIKSHÖFT was performed. Sex differences in comorbidity according to the American Society of Anesthesiologists score and complications 4 months after a hip fracture were registered. Multivariate logistic regression analysis was performed to identify factors related to complications.Results: Male sex was associated with worse general health according to the American Society of Anesthesiologists classification (P=0.005 and with more comorbidities (P<0.001. Male sex emerged as a risk factor for developing pneumonia (P<0.001, and additionally, 18% of the men suffered from cardiac complications compared with 13% of the females (P=0.018. Female sex was predisposed for urinary tract infections, 30% vs 23

Abundance and composition of near surface microplastics and plastic debris in the Stockholm Archipelago, Baltic Sea.

Science.gov (United States)

Gewert, Berit; Ogonowski, Martin; Barth, Andreas; MacLeod, Matthew

2017-07-15

We collected plastic debris in the Stockholm Archipelago using a manta trawl, and additionally along a transect in the Baltic Sea from the island of Gotland to Stockholm in a citizen science study. The samples were concentrated by filtration and organic material was digested using hydrogen peroxide. Suspected plastic material was isolated by visual sorting and 59 of these were selected to be characterized with Fourier transform infrared spectroscopy. Polypropylene and polyethylene were the most abundant plastics identified among the samples (53% and 24% respectively). We found nearly ten times higher abundance of plastics near central Stockholm than in offshore areas (4.2×10 5 plastics km -2 compared to 4.7×10 4 plastics km -2 ). The abundance of plastic debris near Stockholm was similar to urban areas in California, USA, and the overall abundance in the Stockholm Archipelago was similar to plastic abundance reported in the northwestern Mediterranean Sea. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

Logics of pre-merger decision-making processes: the case of Karolinska University Hospital.

Science.gov (United States)

Choi, Soki; Brommels, Mats

2009-01-01

The purpose of this paper is to examine how and why a decision to merge two university hospitals in a public context might occur by using an in-depth case study of the pre-merger process of Karolinska University Hospital. Based on extensive document analysis and 35 key informant interviews the paper reconstructed the pre-merger process, searched for empirical patterns, and interpreted those by applying neo-institutional theory. Spanning nearly a decade, the pre-merger process goes from idea generation through transition to decision, and took place on two arenas, political, and scientific. Both research excellence and economic efficiency are stated merger motives. By applying a neo-institutional perspective, the paper finds that the two initial phases are driven by decision rationality, which is typical for political organizations and that the final phase demonstrated action rationality, which is typical for private firms. Critical factors behind this radical change of decision logic are means convergence, uniting key stakeholder groups, and an economic and political crisis, triggering critical incidents, which ultimately legitimized the formal decision. It is evident from the paper that merger decisions in the public sector might not necessarily result from stated and/or economic drivers only. This paper suggests that a change of decision logic from decision to action rationality might promote effective decision making on large and complex issues in a public context. This is the first systematic in-depth study of a university hospital merger employing a decision-making perspective.

Raid, Kaljo: Symphony No. 2, "Stockholm" / Guy S. Rickards

Index Scriptorium Estoniae

Rickards, Guy S.

1996-01-01

Uuest heliplaadist "Raid, Kaljo: Symphony No. 2, "Stockholm"; Tubin, Eduard: Elegy for Strings (arr. Raid). Symphony No. 11 (orch. Raid). Estonian State Symphony Orchestra, Arvo Volmer". Koch International Classics 37291-2 (48 minutes:DDD)

Fluxes of 13 selected pharmaceuticals in the water cycle of Stockholm, Sweden.

Science.gov (United States)

Wahlberg, C; Björlenius, B; Paxéus, N

2011-01-01

Mass flows of 13 pharmaceutical active ingredients (APIS) found in drinking water were studied in the water cycle of Stockholm. Data were collected by analyzing samples of surface water, raw water and drinking water as well as influents, effluents and sludges from waste water treatment plants (WWTPs) in Stockholm area. A mass balance was performed, based on sold amounts of pharmaceuticals and the measured concentrations in water and sludge. The selected APls were all present in WWTP effluents and the removal rates for many of them were poor. Mass balance calculations showed that the three studied WWTPs in Stockholm release considerable amounts of the selected APIs into the Baltic Sea while the portions ending up in WWTP sludge were significantly lower. The levels of APIs found in drinking water are low at present, but may increase in the future unless the releases from WWTPs in the catchment of Lake Mälären are mitigated.

Part II. Therapy for rheumatoid arthritis

Directory of Open Access Journals (Sweden)

Natalia Viktorovna Demidova

2013-01-01

Full Text Available On 23–25 May 2013, the Karolinska Institute (Stockholm, Sweden with the support of MSD company held a meeting on a Clinical Observational Program for rheumatologists, which was attended by the well-known rheumatologists and leading specialists of the Institute Prof. R. van Vollenhoven, Prof. L. Klareskog, Dr. E. af Klint, and Dr. C. Carlens. The reports and interactive sessions discussed the problems of rheumatoid arthritis (RA, including early RA (pathology, pathogenesis, and treatment, registers of with rheumatic diseases; ultrasound diagnosis of inflammatory locomotor diseases; biological therapy for rheumatic diseases; organization of work in the research immunological laboratory, outpatient/day hospital units of a rheumatology clinic. The Program was also attended by physicians from different European countries (Sweden, Germany, Russia, Spain, Greece, etc.. Below is given an overview of the proceedings of the Clinical Observational Program.

Part I. Respiratory system involvement in patients with rheumatoid arthritis

Directory of Open Access Journals (Sweden)

Ruzana Ramilovna Samigullina

2013-01-01

Full Text Available On 23–25 May 2013, the Karolinska Institute (Stockholm, Sweden with the support of MSD company held a meeting on a Clinical Observational Program for rheumatologists, which was attended by the well-known rheumatologists and leading specialists of the Institute Prof. R. van Vollenhoven, Prof. L. Klareskog, Dr. E. af Klint, and Dr. C. Carlens. The reports and interactive sessions discussed the problems of rheumatoid arthritis (RA, including early RA (pathology, pathogenesis, and treatment, registers of with rheumatic diseases; ultrasound diagnosis of inflammatory locomotor diseases; biological therapy for rheumatic diseases; organization of work in the research immunological laboratory, outpatient/day hospital units of a rheumatology clinic. The Program was also attended by physicians from different European countries (Sweden, Germany, Russia, Spain, Greece, etc.. Below is given an overview of the proceedings of the Clinical Observational Program.

Comparing two versions of the Karolinska Sleepiness Scale (KSS).

Science.gov (United States)

Miley, Anna Åkerstedt; Kecklund, Göran; Åkerstedt, Torbjörn

2016-01-01

The Karolinska Sleepiness Scale (KSS) is frequently used to study sleepiness in various contexts. However, it exists in two versions, one with labels on every other step (version A), and one with labels on every step (version B) on the 9-point scale. To date, there are no studies examining whether these versions can be used interchangeably. The two versions were here compared in a 24 hr wakefulness study of 12 adults. KSS ratings were obtained every hour, alternating version A and B. Results indicated that the two versions are highly correlated, do not have different response distributions on labeled and unlabeled steps, and that the distributions across all steps have a high level of correspondence (Kappa = 0.73). It was concluded that the two versions are quite similar.

MARITICIDE AND THE STOCKHOLM SYNDROME. THE PROFILE OF WOMAN IMPRISONED FOR MARITICIDE

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RALUCA PAVEL

2016-01-01

Full Text Available This study analyzes the correlation between female crime and Stockholm syndrome. Due to the fact that researchers focused in their studies on crimes committed by men, criminologists, sociologists and psychologists concentrated little time and attention to the female crime phenomenon. In this article I focused on the sociological interpretation of the results obtained by participant observation, an interview and a questionnaire on the Stockholm syndrome, applied to a number of 25 women imprisoned in Târgşor Prison for the murdering of their partner

Application of Haddon’s matrix in qualitative research methodology: an experience in burns epidemiology

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Deljavan R

2012-07-01

Full Text Available Reza Deljavan,1 Homayoun Sadeghi-Bazarganim,2,3 Nasrin Fouladim,4 Shahnam Arshi,5 Reza Mohammadi61Injury Epidemiology and Prevention Research Center, 2Neuroscience Research Center, Department of Statistics and Epidemiology, Tabriz University of Medical Sciences, Tabriz, Iran; 3Public Health Department, Karolinska Institute, Stockholm, Sweden; 4Ardabil University of Medical Sciences, Ardabil, Iran; 5Shahid Beheshti University of Medical Sciences, Tehran, Iran; 6Public Health Department, Karolinska Institute, Stockholm, SwedenBackground: Little has been done to investigate the application of injury specific qualitative research methods in the field of burn injuries. The aim of this study was to use an analytical tool (Haddon’s matrix through qualitative research methods to better understand people’s perceptions about burn injuries.Methods: This study applied Haddon’s matrix as a framework and an analytical tool for a qualitative research methodology in burn research. Both child and adult burn injury victims were enrolled into a qualitative study conducted using focus group discussion. Haddon’s matrix was used to develop an interview guide and also through the analysis phase.Results: The main analysis clusters were pre-event level/human (including risky behaviors, belief and cultural factors, and knowledge and education, pre-event level/object, pre-event phase/environment and event and post-event phase (including fire control, emergency scald and burn wound management, traditional remedies, medical consultation, and severity indicators. This research gave rise to results that are possibly useful both for future injury research and for designing burn injury prevention plans.Conclusion: Haddon’s matrix is applicable in a qualitative research methodology both at data collection and data analysis phases. The study using Haddon’s matrix through a qualitative research methodology yielded substantially rich information regarding burn injuries

Estimated prevalence and incidence of diagnosed ADHD and health care utilization in adults in Sweden – a longitudinal population-based register study

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Polyzoi M

2018-05-01

Full Text Available Maria Polyzoi,1 Ewa Ahnemark,2 Emma Medin,1,3 Ylva Ginsberg4,5 1PAREXEL International, Stockholm, Sweden; 2Medical Affairs Department, Shire Sweden AB, Stockholm, Sweden; 3Department of Learning, Informatics, Management and Ethics, Karolinska Institutet, Stockholm, Sweden; 4Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; 5Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Institutet, Stockholm, Sweden Background: Although the worldwide prevalence of attention-deficit/hyperactivity disorder (ADHD in adults is estimated to be between 2% and 5%, it is considered to be underdiagnosed. This register study explored the prevalence of diagnosed ADHD and incidence of newly diagnosed ADHD in Swedish adults over time, and assessed comorbidities and pharmacologic treatment. Methods: National Patient Register data were used to estimate the overall prevalence of adults (≥18 years with a registered ADHD diagnosis from 2006 to 2011, and the incidence of newly registered diagnoses from 2007 to 2011. Data from the Prescribed Drug Register were used to estimate the mean dose of the most frequently prescribed ADHD medication. Results: The estimated annual prevalence (N=44,364 of diagnosed ADHD increased from 0.58 per 1,000 persons in 2006 to 3.54 per 1,000 persons in 2011. The estimated annual incidence of newly diagnosed ADHD (N=24,921 increased from 0.39 per 1,000 persons to 0.90 per 1,000 persons between 2007 and 2011. At least one comorbidity was diagnosed in 52.6% of adults with ADHD (54.0% of newly diagnosed adults, with anxiety, substance use disorders, and depression being the most common. Among all adults with ADHD, 78.9% (65.7% of newly diagnosed adults were prescribed ADHD medication and one-third were prescribed more than one add-on medication. Osmotic release oral system methylphenidate was the most commonly used medication. The mean daily dose was 51.5 mg, and was

Long-term sick-leavers with fibromyalgia: Comparing their multidisciplinarily assessed characteristics with those  of others with chronic pain conditions and depression

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Jürgen Linder

2009-01-01

Full Text Available Jürgen Linder1, Kristina Schüldt Ekholm2,3,4, Göran Lundh1, Jan Ekholm2,31Diagnostic Centre, Division of Psychiatry, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; 2Division of Rehabilitation Medicine, Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden; 3Stockholm University Rehabilitation Medicine Clinic, Danderyd Hospital, Stockholm, Sweden; 4Division of Rehabilitation Science, Department of Health Science, Mid-Sweden University, Campus Östersund, SwedenObjective: The aim was to gain knowledge of fibromyalgia (FM patients on long-term sick leave and with particular difficulties in resuming work, and to compare them with patients with myalgia, back or joint diagnoses, and depression.Methods: Patients were identified by and referred from social insurance offices and were multidisciplinarily examined by three board-certified specialists in psychiatry, orthopedic surgery and rehabilitation medicine. Ninety-two women were diagnosed with FM only. Three female comparison groups were chosen: depression, back/joint diagnoses, and myalgia.Results and conclusions: Ceaseless pain was reported by 73% of FM patients, 54% of back/joint diagnoses patients, 43% of myalgia patients, and 35% of depression patients. The distribution of pain (>50% in FM patients was to almost all regions of the body, and in depression patients to the lower dorsal neck, upper shoulders and lumbosacral back but not in the anterior body. Reduced sleep was more evident in FM patients. FM patients did not meet more criteria for personality disorder than patients with the other somatic pain conditions. The most common dimension of “personality traits” of somatic pain conditions was the “obsessive compulsive” but at a level clearly below that indicating a personality disorder. More FM patients experienced disabilities, the most common being in the mobility and domestic-life areas.Keywords: fibromyalgia

Urban Metal Flows - A Case Study of Stockholm. Review and Conclusions

International Nuclear Information System (INIS)

Bergbaeck, B.; Johansson, K.; Mohlander, U.

2001-01-01

Metals have rapidly accumulated in the anthroposphere, especially in urban areas, indicating possible environmental and resource problems. Here, Stockholm City was chosen for a case study of urban metal flows, i.e. metal inflow to, metals in the stock of,and metal outflow from the anthroposphere to the biosphere. The metal stock of Stockholm is large and still growing. The large amounts of metals in the solid waste fraction totally dominate the outflow from the city. For major parts of the stock, the emissions from goods in use are negligible. There are, however,goods applications corresponding to significant emissions: e.g. the traffic sector (Cu, Zn, Cr, Ni, Pb), the tapwater system (Cu), roofs/fronts or other metal surfaces (Cu, Zn). Today's known metal flows from the anthroposphere of Stockholm to the biosphere and sewage sludge are quantitatively dominated by Zn(34 ton y -1 ) and Cu (14 ton y -1 ). Historical and present emissions have resulted in high metal concentrations in sediments (especially Cd, Hg and Pb, but also Cu and Zn), groundwater (Cu, Hg) and in soils (Hg, Cu, Pb). At present the annual median concentrations are below the Swedish limits for metals in sewage sludge, even if the safety margins are small for Cd, Hg and to some extent Cu. The flows of Cu and Zn to Stockholm soils are high with a significant accumulation indicating an environmental impact in a longer time perspective.High levels of metals in surface sediments in the water environments reflects an ongoing input where these metals are transported from known (Cu, Zn) and or partly unknown (Cd, Hg, Pb) sources. In future urban areas, monitoring of metal flows must be performed both in the anthroposphere and the biospherein order to have a pro active approach to urban environmental problems and to get prompt answers to measures taken

Associations between generic substitution and patient-related factors

DEFF Research Database (Denmark)

Østergaard Rathe, Jette

Associations between generic substitution and patient-related factors Jette Østergaard Rathe1, Pia V. Larsen1, Morten Andersen2, Janus L. Thomsen3, Maja S. Paulsen1, Jens Søndergaard1 1. Research Unit of General Practice, Institute of Public Health, University of Southern Denmark 2. Centre...... for Pharmacoepidemiology, Karolinska Institutet, Department of Medicine Solna, Stockholm, Sweden 3. Danish Quality Unit of General Practice, Odense, Denmark Background Generic substitution means that chemically equivalent but less expensive drugs are dispensed in place of a brand name product. Although generic medicines...... by definition are bioequivalent to their brand name counterparts there are concerns about whether generic substitution is always accompanied by clinical equivalence in terms of effectiveness and that it may cause concerns and thereby causing some skepticism towards generic substitution. There is, however...

Pilot study of personality traits assessed by the Karolinska Scales of Personality (KSP) in asthma, atopy, and rhinitis.

Science.gov (United States)

Runeson, Roma; Wahlstedt, Kurt; Norbäck, Dan

2011-12-01

Asthma and atopy are common diseases. To study associations between personality and asthma, atopy, rhinitis, and personality traits were measured on the Karolinska Scales of Personality for 193 persons working in 19 buildings with suspected indoor air problems. In addition, information on history of atopy, asthma, and rhinitis was collected by postal questionnaire. In analyses, asthma was associated with higher impulsiveness scores, and atopy in non-asthmatics was associated with higher social desirability scores and lower irritability, guilt, and impulsiveness scores. Non-atopic rhinitis was associated with scores on several anxiety-related scales, while atopic rhinitis was not associated with scores on the Karolinska Scales of Personality. This exploration implies that asthma, atopy, and rhinitis may be associated with various but different personality trait scores. The finding of such personality trait associations in persons with non-asthmatic atopy raises the question of a potential role of an emotional conflict in atopy and the role of personality in asthma, atopy, and rhinitis.

PERSISTENT ORGANIC POLLUTANS (POPS DAN KONVENSI STOCKHOLM

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Lina Warlina

2010-07-01

Full Text Available Persistent organic pollutants (POPs are toxic chemicals that adversely affect human health and the environment around the world. Because they can be transported by wind and water, most POPs generated in one country can affect people and wildlife far from where they are used and released. They persist for long periods of time in the environment and can accumulate and pass from one species to the next through the food chain. To address this global concern, many countries in the world joined forces with 90 other countries and the European Community to sign a groundbreaking United Nations treaty in Stockholm, Sweden, in May 2001, known as the Stockholm Convention. One of important agreement is all countries agreed to reduce or eliminate the production, use, and/or release of 12 key POPs. The Convention specifies a scientific review process that could lead to the addition of other POPs chemicals of global concern. POPs include a range of substances that include intentionally produced chemicals currently or once used in agriculture, disease control, manufacturing, or industrial processes. Also it can be produced by unintentionally produced chemicals, such as dioxins, that result from some industrial processes and from combustion (for example, municipal and medical waste incineration and backyard burning of trash.

Stem cells: a model for screening, discovery and development of drugs

OpenAIRE

Kitambi, Satish Srinivas; Chandrasekar, Gayathri

2011-01-01

Satish Srinivas Kitambi1, Gayathri Chandrasekar21Department of Medical Biochemistry and Biophysics; 2Department of Biosciences, Karolinska Institutet, Stockholm, SwedenAbstract: The identification of normal and cancerous stem cells and the recent advances made in isolation and culture of stem cells have rapidly gained attention in the field of drug discovery and regenerative medicine. The prospect of performing screens aimed at proliferation, directed differentiation, and toxicity and efficac...

Gender dysphoria in adolescence: current perspectives

OpenAIRE

Kaltiala-Heino,Riittakerttu; Bergman,Hannah; Työläjärvi,Marja; Frisen,Louise

2018-01-01

Riittakerttu Kaltiala-Heino,1–3 Hannah Bergman,4 Marja Työläjärvi,2 Louise Frisén4 1Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland; 2Department of Adolescent Psychiatry, Tampere University Hospital, Tampere, Finland; 3Vanha Vaasa Hospital, Vaasa, Finland; 4Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden Abstract: Increasing numbers of adolescents are seeking treatment at gender identi...

Hammarby Sjöstad in Stockholm a model case?

DEFF Research Database (Denmark)

Grønlund, Bo

2010-01-01

central government agencies have contributed to put these guidelines in practice. Representatives have also taken part in similar work at CEN in Brussels. In Sweden, the Stockholm Police started to work out guidelines and give advice - with the mixed new urban district Ärvinge near Kista as their primary...

Liver transplantation for HCV cirrhosis at Karolinska University Hospital Huddinge, Stockholm.

Science.gov (United States)

Gjertsen, H; Weiland, O; Oksanen, A; Söderdahl, G; Broomé, U; Ericzon, B-G

2006-10-01

Hepatitis C virus (HCV)-induced cirrhosis is the major indication for liver transplantation globally, and an increasing indication for liver transplantation in Sweden. We have retrospectively examined the 120 patients transplanted for HCV cirrhosis from 1987 through 2005, including 11 who received more than one graft. The 1-, 3-, and 5-year postoperative survivals for all patients transplanted for HCV with or without hepatocellular cancer (HCC) were 77%, 66%, and 53%, respectively. HCV patients without HCC had a 1-, 3-, and 5-year survivals of 78%, 73%, and 61%, compared with 84%, 79% and 74%, respectively, for patients transplanted with chronic liver diseases without cancer or HCV. The number of patients with HCV cirrhosis transplanted in our center is increasing. Compared with patients transplanted for other chronic liver diseases, we experienced inferior results among patients with HCV cirrhosis.

The Data Acquisition System of the Stockholm Educational Air Shower Array

Science.gov (United States)

Hofverberg, P.; Johansson, H.; Pearce, M.; Rydstrom, S.; Wikstrom, C.

2005-12-01

The Stockholm Educational Air Shower Array (SEASA) project is deploying an array of plastic scintillator detector stations on school roofs in the Stockholm area. Signals from GPS satellites are used to time synchronise signals from the widely separated detector stations, allowing cosmic ray air showers to be identified and studied. A low-cost and highly scalable data acquisition system has been produced using embedded Linux processors which communicate station data to a central server running a MySQL database. Air shower data can be visualised in real-time using a Java-applet client. It is also possible to query the database and manage detector stations from the client. In this paper, the design and performance of the system are described

Monitoring of air pollution in Stockholm county. Results up to September 1999; Oevervakning av luftfoeroreningar i Stockholms laen. Resultat till och med september 1999

Energy Technology Data Exchange (ETDEWEB)

Akselsson, Cecilia [ed.

2000-05-01

Swedish Environmental Research Inst. have measured deposition of air pollutants, soil water quality, and air pollution levels in forested areas in different parts of Sweden. This report treats Stockholm county and the compilation covers the period 1992-1999, with more detailed monitoring for 1998-1999.

Responding to Multiple Institutional Logics in Inter-institutional Temporary Organizations

DEFF Research Database (Denmark)

Söderlund, Jonas; Pemsel, Sofia

2016-01-01

This paper draws on findings from a unique case study of a temporary organization that carried the responsibility for the planning and construction of a new super hospital in Stockholm, Sweden. Our empirical study explores how this temporary organization responded to requirements from different...... and sometimes conflicting institutional logics. The paper identifies four distinct response strategies that project actors relied upon to deal with the multiplicity of logics: total integration, partial decoupling, avoidance, and surfing. We discuss how these response strategies were used in the studied case...

Replacing sedentary time with physical activity: a 15-year follow-up of mortality in a national cohort

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Dohrn IM

2018-01-01

Full Text Available Ing-Mari Dohrn,1 Lydia Kwak,2 Pekka Oja,3 Michael Sjöström,4 Maria Hagströmer1,5 1Department of Neurobiology, Care Sciences and Society (NVS, 2Institute of Environmental Medicine (IMM, Karolinska Institutet, Stockholm, Sweden; 3UKK Institute, Tampere, Finland; 4Department of Biosciences and Nutrition (BioNut, Karolinska Institutet, 5Functional Area Occupational Therapy and Physiotherapy, Karolinska University Hospital, Stockholm, Sweden Background: Sedentary behavior is associated with health risks in adults. The potential benefits of reducing sedentary time may be dependent not only on decrease per se, but also on the type of activity it replaces. Few longitudinal studies have investigated the effects on mortality when replacing objectively assessed sedentary time with another physical activity (PA behavior. Objective: To investigate the effects of replacing objectively assessed sedentary time with time in light-intensity PA or moderate-vigorous PA (MVPA on all-cause mortality, cardiovascular disease (CVD mortality or cancer mortality in a cohort with 15 years follow-up time.Methods: In total, 851 women and men from the population-based Sweden Attitude Behaviour and Change study were included. Time spent sedentary, in light-intensity PA and in MVPA were assessed using an Actigraph 7164 accelerometer. Mortality data were obtained from Swedish registers. Cox proportional hazards models estimated hazard ratios (HR of mortality with 95% confidence intervals (CI and isotemporal substitution models were used to estimate the effect of replacing sedentary behavior with PA for the same amount of time.Results: Over a follow-up of 14.2 years (SD 1.9 with 12,117 person-years at risk, 79 deaths occurred, 24 deaths from CVD, 27 from cancer, and 28 from other causes. Replacing 30 minutes/day of sedentary time with light-intensity PA was associated with significant reduction in all-cause mortality risk (HR: 0.89, 95% CI: 0.81-0.98 and CVD mortality risk (HR

Teenage outcomes after speech and language impairment at preschool age

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Ek U

2012-05-01

Full Text Available Ulla Ek1, Fritjof Norrelgen3,4, Joakim Westerlund2, Andrea Dahlman5, Elizabeth Hultby5, Elisabeth Fernell61Department of Special Education, 2Department of Psychology, Stockholm University, Stockholm, Sweden; 3Department of Speech and Language Pathology, Karolinska University Hospital, Stockholm, Sweden; 4Department of Clinical Neuroscience, 5CLINTEC/Division of Speech and Language Pathology, Karolinska Institutet, Stockholm, Sweden; 6The Gillberg Neuropsychiatry Centre, Sahlgrenska Academy, University of Gothenburg and the Research and Development Centre, Skaraborg Hospital, Skövde, SwedenAim: Ten years ago, we published developmental data on a representative group of children (n = 25 with moderate or severe speech and language impairment, who were attending special preschools for children. The aim of this study was to perform a follow-up of these children as teenagers.Methods: Parents of 23 teenagers participated in a clinical interview that requested information on the child's current academic achievement, type of school, previous clinical assessments, and developmental diagnoses. Fifteen children participated in a speech and language evaluation, and 13 participated in a psychological evaluation.Results: Seven of the 23 teenagers had a mild intellectual disability, and another three had borderline intellectual functioning. Nine had symptoms of disorders on the autism spectrum; five of these had an autism spectrum disorder, and four had clear autistic traits. Six met criteria for attention-deficit hyperactivity disorder (ADHD/subthreshold ADHD. Thirteen of 15 teenagers had a moderate or severe language impairment, and 13 of 15 had a moderate or severe reading impairment. Overlapping disorders were frequent. None of the individuals who underwent the clinical evaluation were free from developmental problems.Conclusion: A large number of children with speech and language impairment at preschool age had persistent language problems and/or met the

Temporal and spatial patterns of suicides in Stockholm's subway stations.

Science.gov (United States)

Uittenbogaard, Adriaan; Ceccato, Vania

2015-08-01

This paper investigates the potential temporal and spatial variations of suicides in subway stations in Stockholm, Sweden. The study also assesses whether the variation in suicide rates is related to the station environments by controlling for each station's location and a number of contextual factors using regression models and geographical information systems (GIS). Data on accidents are used as references for the analysis of suicides. Findings show that suicides tend to occur during the day and in the spring. They are concentrated in the main transportation hubs but, interestingly, during off-peak hours. However, the highest rates of suicides per passenger are found in Stockholm's subway stations located in the Southern outskirts. More than half of the variation in suicide rates is associated with stations that have walls between the two sides of the platform but still allow some visibility from passers-by. The surrounding environment and socioeconomic context show little effect on suicide rates, but stations embedded in areas with high drug-related crime rates tend to show higher suicide rates. Copyright © 2015 Elsevier Ltd. All rights reserved.

Early-Onset Dementia

DEFF Research Database (Denmark)

Konijnenberg, Elles; Fereshtehnejad, Seyed-Mohammad; Kate, Mara Ten

2017-01-01

BACKGROUND: Early-onset dementia (EOD) is a rare condition, with an often atypical clinical presentation, and it may therefore be challenging to diagnose. Specialized memory clinics vary in the type of patients seen, diagnostic procedures applied, and the pharmacological treatment given. The aim...... of this study was to investigate quality-of-care indicators in subjects with EOD from 3 tertiary memory clinics in 3 European countries. METHODS: We included 1325 newly diagnosed EOD patients, ages 65 years or younger, between January 1, 2007 and December 31, 2013, from the Danish Dementia Registry...... (Rigshospitalet, Copenhagen), the Swedish Dementia Registry ("SveDem", Karolinska University Hospital, Stockholm), and the Amsterdam Dementia Cohort (VU University Medical Center). RESULTS: The frequency of EOD among all dementia patients was significantly lower in Copenhagen (410, 20%) and Stockholm (284, 21...

Child mortality in Stockholm during 1885-1910

DEFF Research Database (Denmark)

Burström, B; Diderichsen, Finn; Smedman, L

1999-01-01

on the risk of measles death. Individual entries in a population-based register and on death certificates for children aged 0-15 years living in one parish in Stockholm in 1885, 1891, and 1910 (n = 36,718) were used to analyze cause-specific and overall death rates in relation to household size and the number...... crowding and the risk of death from pneumonia and bronchitis disappeared when controlling for other risk factors. A negative association between the risk of overall death and large household size became significantly positive when controlling for other risk factors. The increased risk of death from measles...

Nitrate and nitrite in biology, nutrition and therapeutics

Science.gov (United States)

Lundberg, Jon O.; Gladwin, Mark T.; Ahluwalia, Amrita; Benjamin, Nigel; Bryan, Nathan S.; Butler, Anthony; Cabrales, Pedro; Fago, Angela; Feelisch, Martin; Ford, Peter C.; Freeman, Bruce A.; Frenneau, Michael; Friedman, Joel; Kelm, Malte; Kevil, Christopher G.; Kim-Shapiro, Daniel B.; Kozlov, Andrey V.; Lancaster, Jack R.; Lefer, David J.; McColl, Kenneth; McCurry, Kenneth; Patel, Rakesh; Petersson, Joel; Rassaf, Tienush; Reutov, Valentin P.; Richter-Addo, George B.; Schechter, Alan; Shiva, Sruti; Tsuchiya, Koichiro; van Faassen, Ernst E.; Webb, Andrew J.; Zuckerbraun, Brian S.; Zweier, Jay L.; Weitzberg, Eddie

2014-01-01

Inorganic nitrate and nitrite from endogenous or dietary sources are metabolized in vivo to nitric oxide (NO) and other bioactive nitrogen oxides. The nitrate-nitrite-NO pathway is emerging as an important mediator of blood flow regulation, cell signaling, energetics and tissue responses to hypoxia. The latest advances in our understanding of the biochemistry, physiology and therapeutics of nitrate, nitrite and NO were discussed during a recent two-day meeting at the Nobel Forum, Karolinska Institutet in Stockholm. PMID:19915529

Cytochrome P450 induction by rifampicin in healthy subjects: determination using the Karolinska cocktail and the endogenous CYP3A4 marker 4beta-hydroxycholesterol.

Science.gov (United States)

Kanebratt, K P; Diczfalusy, U; Bäckström, T; Sparve, E; Bredberg, E; Böttiger, Y; Andersson, T B; Bertilsson, L

2008-11-01

The Karolinska cocktail, comprising caffeine, losartan, omeprazole, and quinine, was given before and after administration of rifampicin (20, 100, or 500 mg daily) to measure induction of cytochrome P450 (P450) enzymes. Rifampicin was given for 14 days to eight healthy subjects (all of whom possessed at least one wild-type CYP2C9 and one wild-type CYP2C19 gene) in each dose group. 4beta-hydroxycholesterol was assessed as an endogenous marker of CYP3A4 induction. A fourfold induction of CYP3A4 was seen at the highest dose by both quinine:3'-hydroxyquinine and 4beta-hydroxycholesterol measurements (P Karolinska cocktail and 4beta-hydroxycholesterol can be used for an initial screening of the induction properties of a drug candidate.

The dynamics of social-ecological systems in urban landscapes: Stockholm and the National Urban Park, Sweden.

Science.gov (United States)

Elmqvist, T; Colding, J; Barthel, S; Borgstrom, S; Duit, A; Lundberg, J; Andersson, E; Ahrné, K; Ernstson, H; Folke, C; Bengtsson, J

2004-06-01

This study addresses social-ecological dynamics in the greater metropolitan area of Stockholm County, Sweden, with special focus on the National Urban Park (NUP). It is part of the Millennium Ecosystem Assessment (MA) and has the following specific objectives: (1) to provide scientific information on biodiversity patterns, ecosystem dynamics, and ecosystem services generated; (2) to map interplay between actors and institutions involved in management of ecosystem services; and (3) to identify strategies for strengthening social-ecological resilience. The green areas in Stockholm County deliver numerous ecosystem services, for example, air filtration, regulation of microclimate, noise reduction, surface water drainage, recreational and cultural values, nutrient retention, and pollination and seed dispersal. Recreation is among the most important services and NUP, for example, has more than 15 million visitors per year. More than 65 organizations representing 175,000 members are involved in management of ecosystem services. However, because of population increase and urban growth during the last three decades, the region displays a quite dramatic loss of green areas and biodiversity. An important future focus is how management may reduce increasing isolation of urban green areas and enhance connectivity. Comanagement should be considered where locally managed green space may function as buffer zones and for management of weak links that connect larger green areas; for example, there are three such areas around NUP identified. Preliminary results indicate that areas of informal management represent centers on which to base adaptive comanagement, with the potential to strengthen biodiversity management and resilience in the landscape.

A liquidity study on the Nasdaq OMX Stockholm exchange

OpenAIRE

Leffler, Fredrik; Dworsky Nylander, Adam

2012-01-01

As the demand for liquidity risk management has increased, the importance of comprehensive liquidity assessments of exchanges has been highlighted. This thesis investigates the liquidity on the Nasdaq OMX Stockholm exchange by using daily end of day data. The transaction cost is evaluated using the Holden model and the price impact from trading is evaluated using the Illiq model. Considering the three segments; small cap, mid cap, and large cap, the results suggest that both the transaction c...

Patients' experience of care and treatment outcome at the Department of Clinical Oral Physiology, Dental Public Service in Stockholm.

Science.gov (United States)

Christidis, Nikolaos; Smedberg, Erica; Hägglund, Helene; Hedenberg-Magnusson, Britt

2010-01-01

Chronic pain conditions in the craniofacial region are common in the adult population with a prevalence of approximately 10%. They are included in the generic term temporomandibular disorders (TMD) and accompanied by restricted mouth opening capacity, chewing difficulties, headache and neck pain. These pain conditions cause psychological suffering, impaired social relations, and recurrent sick leave, subsequently leading to frequent use of health care, medication and consequently to a decreased quality of life. Approximately 25% of children have signs of TMD and girls are shown to be more affected than boys. These signs increase with age and in the adult population the prevalence is approximately 38-40%, also here with a higher frequency in women than in men. This study comprised 198 patients who answered an anonymous questionnaire after termination of their treatment. The study aimed to investigate the activity at the department of clinical oral physiology at the Folktandvården Eastman Institute in Stockholm, Sweden, regarding the patients and their cause of care-seeking, as well as the patients' subjective experiences of the specialist care and the treatment outcome. As a secondary aim the purpose was to investigate how/if the clinicians at the department of clinical oral physiology reached their intention of being "curious", "considerate" and "accessible". The results from this study show that the majority of the patients (57.1%) were referred from the dental public service in Stockholm. 71.7% of the patients were young women between the ages of 11 and 20. The main causes of care-seeking were temporomandibular joint clickings, followed by limited jaw movement, headache and orofacial pain. Further, an immense majority of the patients (89.9%) were very satisfied with their treatment as well as the treatment outcome. These results indicate that the clinicians at the department reached their intention of being "curious", "considerate"and "accessible", which also

Food redistribution in Stockholm : A comparative analysis of two scenarios – with and without a food bank

OpenAIRE

Persson, Anna

2016-01-01

Food waste is a serious problem in today’s society. Functional food waste is going to waste treatment while people are suffering from food insecurity. Food redistribution in form of a central food bank which collects food waste at food companies and delivers it to social organizations is a measure to deal with this issue. Stockholm City Mission plans to start up a central food bank in Stockholm and it is this implementation that is of focus in this report. The purpose of this study is to comp...

New ideas in asthma and allergy research: creating a multidisciplinary graduate school

Science.gov (United States)

Björkstén, Bengt; Graninger, Göran; Ekman, Gunilla Jacobsson

2003-01-01

The spring term of 2001 saw the start of a new, unique graduate research training program at the Centre for Allergy Research at the Karolinska Institutet in Stockholm, Sweden. The program was created to bridge the gaps between basic, clinical, social, and behavioral sciences and to establish a global approach to the study of asthma and allergy. A reflection, two years on, discusses the strategies that are key to this model’s success and the challenges in introducing a multidisciplinary research program. PMID:12975463

Annual report 1977, Particle physics, Institute of Physics, University of Stockholm

International Nuclear Information System (INIS)

1978-01-01

The research in the field of elementary particle physics concerns hadronic processes at high energies, using the facilities offered by CERN and Fermilab, USA. The teams carrying out experiments with bubble chambers are mainly working at the institute, whereas the tems utilizing counter techniques spend long periods at CERN. Experiments at CERN SPS and Fermilab are in progress. The equipment for bubble chamber physics at the institute consists of five scanning tables, one manual measuring machine and the Spiral Reader measuring machine. A computer CD 6400 is available at the institute. The research program comprises study of 100 GeV/c antiproton-deuterium reactions, 12 GeV/c antiproton-deuterium reactions, 9 and 12 GeV/c antiproton-proton reactions studying all annihilation and non-annihilation processes, a detailed study of amplitudes in 4 GeV/c π - p reactions with strange particles, strange particle production in 19 GeV/c pp and study of 19 GeV/c pd. The main emphasis in the future will be on experiments with the European Hybrid Spectrometer system and the Big European Bubble Chamber at SPS. The group participates in the design work and planning for the physics experiments. Research physicists from the group participate in counter experiments at SPS studying elastic scattering at high transverse momenta, elastic scattering of π, K and p sup(+-) at PS energies and study of line reversal invariance in πp and Kp reactions. (author)

School Performance, School Segregation, and Stress-Related Symptoms: Comparing Helsinki and Stockholm

Science.gov (United States)

Modin, Bitte; Karvonen, Sakari; Rahkonen, Ossi; Östberg, Viveca

2015-01-01

This study investigates cross-cultural differences in the interrelation between school performance, school segregation, and stress-related health among 9th-grade students in the greater Stockholm and Helsinki areas. Contrary to the Swedish case, it has been proposed that school performance in Finland is largely independent of the specific school…

Integrating Social Sustainability in Engineering Education at the KTH Royal Institute of Technology

Science.gov (United States)

Björnberg, Karin Edvardsson; Skogh, Inga-Britt; Strömberg, Emma

2015-01-01

Purpose: The purpose of this paper is to investigate what are perceived to be the main challenges associated with the integration of social sustainability into engineering education at the KTH Royal Institute of Technology, Stockholm. Design/methodology/approach: Semi-structured interviews were conducted with programme leaders and teachers from…

The European hadron therapy community touches base

CERN Multimedia

Audrey Ballantine, Manuela Cirilli, Evangelia Dimovasili, Manjit Dosanjh, Seamus Hegarty

2010-01-01

The European hadron therapy community gathered in Stockholm from 3 to 5 September for the annual ENLIGHT workshops. Three of the four EC-funded projects born under the umbrella of ENLIGHT (see box) were discussed in the prestigious Nobel Forum at the Karolinska Institutet.   Souvenir photo from the ENLIGHT workshops On its second birthday, the PARTNER Initial Training Network was especially under the spotlight, as the European Commission conducted a formal project review bringing together the institutes, companies and young researchers involved. The 21 PARTNER researchers experienced the thrill of presenting their work in this privileged setting. During the coffee breaks, they joked about this being their only chance in life to speak in the Nobel Forum – but who knows what these brilliant young minds will achieve! They certainly impressed the European Commission’s Project Officer Gianluca Coluccio and Expert Reviewer Kaisa Hellevuo, who stated that PARTNER is a showcase proj...

Bullying in Context: An Analysis of Psychosomatic Complaints among Adolescents in Stockholm

Science.gov (United States)

Modin, Bitte; Låftman, Sara Brolin; Östberg, Viveca

2015-01-01

Using multilevel modeling, this study examined how different types of bullying, involving both peers and teachers, relate to psychosomatic health complaints. Data were obtained via the Stockholm School Survey from 41,032 ninth- and eleventh-grade students in the years 2004, 2006, 2008, and 2010. Results showed that students involved in bullying as…

Transforming governance and institutions for global sustainability: key insights from the Earth System Governance Project

NARCIS (Netherlands)

Biermann, F.; Abbott, K.; Andresen, S.; Bäckstrand, K.; Bernstein, S.; Betsill, M.M.; Bulkeley, H.; Cashore, B.; Clapp, J.; Folke, C.; Gupta, A.; Gupta, J.; Haas, P.M.; Jordan, A.; Kanie, N.; Kluvánková-Oravská, T.; Lebel, L.; Liverman, D.; Meadowcroft, J.; Mitchell, R.B.; Newell, P.; Oberthür, S.; Olsson, L.; Pattberg, P.; Sánchez-Rodriguez, R.; Schroeder, H.; Underdal, A.; Camargo Vieira, S.; Vogel, C.; Young, O.R.; Brock, A.; Zondervan, R.

2012-01-01

The current institutional framework for sustainable development is by far not strong enough to bring about the swift transformative progress that is needed. This article contends that incrementalism—the main approach since the 1972 Stockholm Conference—will not suffice to bring about societal change

Confident but not theoretically grounded – experienced simulation educators’ perceptions of their own professional development

Directory of Open Access Journals (Sweden)

Allvin R

2017-01-01

Full Text Available Renée Allvin,1 Magnus Berndtzon,2 Liisa Carlzon,3 Samuel Edelbring,4,5 Håkan Hult,6 Magnus Hultin,7 Klas Karlgren,5,8 Italo Masiello,9 Marie-Louise Södersved Källestedt,10 Éva Tamás,11 1Clinical Skills Centre, Faculty of Medicine and Health, School of Medical Sciences, Örebro University, Örebro, 2Metodikum – Skill Centre of Medical Simulation Region County Jönköping, Jönköping, 3Simulation Centre West, Department of Research, Education and Development, Sahlgrenska University Hospital, Gothenburg, 4Department of Medical and Health Sciences, Faculty of Medicine and Health Sciences, Linköping University, Linköping, 5Department of Learning, Informatics, Management and Ethics, Karolinska Institutet, Stockholm, 6Institute of Medicine and Health, Medical Faculty, Linköping University, Linköping, 7Department of Surgical and Perioperative Sciences, Anaesthesiology and Intensive Care, Medical Faculty, Umeå University, Umeå, 8Department of Research, Education and Development and Innovation, Södersjukhuset Hospital, Stockholm, 9Department of Clinical Science and Education, Karolinska Institutet, Södersjukhuset Hospital, Stockholm, 10Clinical Skills Centre, Centre for Clinical Research, Uppsala University, Västerås, 11Department of Cardiovascular Diseases, Institute of Medicine and Health, Medical Faculty, University of Linköping, Linköping, Sweden Background: Medical simulation enables the design of learning activities for competency areas (eg, communication and leadership identified as crucial for future health care professionals. Simulation educators and medical teachers follow different career paths, and their education backgrounds and teaching contexts may be very different in a simulation setting. Although they have a key role in facilitating learning, information on the continuing professional development (pedagogical development of simulation educators is not available in the literature. Objectives: To explore changes in

Effect of air pollution on the epiphytic flora of conifers in the Stockholm region

Energy Technology Data Exchange (ETDEWEB)

Lundstroem, H

1968-01-01

Epiphytic flora (especially lichens) have been investigated in order to see how they respond to air pollution. The study was restricted to those occurring up to a height of 2.3 m from the ground, on trunks of the conifers Picea abies and Pinus silvestries. The area of investigation lies north of Stockholm. Wind diagrams show a slight predominance of winds from Stockholm. This means that polluted air is spread out over the area of investigation. All epiphytic vegetation on the station-trees for which the species were determined are listed. The distribution of lichen species is discussed, especially how air pollution has affected the distributions of the three lichens, Hypogymnia physodes (L.) Zopf (syn. Parmelia physodes (L.) Ach.) Parmeliopsis ambigua (Wulf) Nyl. Pseudevernia furfuraceae (L.) Zopf (syn. Parmelia furfuraceae (L.) Ach.). Maps of distributions have been made for the most common epiphytes.

Framing the role of Decision Support in the case of Stockholm Congestion Charging Trial

DEFF Research Database (Denmark)

Gudmundsson, Henrik; Ericsson, Eva; Hugosson, Muriel Besser

2009-01-01

the way for investigating the use and role of ‘Decision Support’ in the Stockholm Congestion Charging experiment. We adopt a definition of Decision Support as the systematic application of externally produced knowledge in transport planning and policy making processes. We then derive an analytical...... framework from the research literature on ‘knowledge utilization’ in policy making. This research has generally found that both ‘technical’, ‘communicative’, and ‘institutional’ aspects of the Decision Support matter for its influence on actual policy making processes and results. In our analysis we find...... in a Swedish context, and the introduction of the Stockholm system has been highly controversial. Considerable efforts have therefore been undertaken to provide information that could serve as ‘Decision Support’ along the way. This has included e.g. modelling and forecasts before the Trial, a comprehensive...

The environmental fate of polybrominated diphenyl ethers in the centre of Stockholm - Assessment using a multimedia fugacity model

Energy Technology Data Exchange (ETDEWEB)

Palm, Anna

2001-01-01

A local-scale assessment of the environmental fate of three congeners of polybrominated diphenyl ethers (PBDEs) has been performed for the centre of Stockholm. The partitioning properties and main transport processes of these congeners in Stockholm are identified using a site-specific multimedia fugacity model, called CeStoc, that was developed and parameterized for the area of interest. CeStoc was based on level III and IV fugacity models. Five compartments were included: air, water, soil, sediment and an organic film covering the impervious surfaces in the city. The model was satisfactory calibrated with the PAH fluoranthene, before it was run for the compounds of interest. Validation with environmental levels of PBDEs was made where possible, showing reasonable agreement with model results. According to the CeStoc results, the majority of the PBDEs emitted are transported out of the region through air advection, implying that Stockholm may act as a source for chemical release to other regions. The largest sink for PBDEs in Stockholm is soil, closely followed by sediment, the two compartments together accounting for about 98 % of the total amount remaining in the system. The degree of bromination does not seem to have a large impact on the environmental distribution in this area, but further research on e.g. physical-chemical properties is necessary before this can be finally concluded. Predicted concentrations of individual PBDE congeners in sediment and water lie in the same range as measured levels of individual PCB-congeners, indicating that PBDEs could have an environmental impact of about the same size as the PCBs.

Time trends in 20 years of medication use in older adults: Findings from three elderly cohorts in Stockholm, Sweden.

Science.gov (United States)

Craftman, Åsa Gransjön; Johnell, Kristina; Fastbom, Johan; Westerbotn, Margareta; von Strauss, Eva

2016-01-01

New drugs and expanded drug indications are constantly being introduced. Welfare states strive to provide equity in drug treatment for all of its citizens and todaýs healthcare systems spend financial resources on drugs for the elderly in a higher rate than for any other age group. Drug utilization in elderly persons has an impact in health and wellbeing in older people. It was to describe the changes in medication use including people aged 78 years and over regardless of residence and other characteristics over 20 years. The study population consisted of 4304 participants in three population-based cross-sectional surveys conducted in the Kungsholmen area of central Stockholm, Sweden. The participant's current drug utilization was reviewed by physicians following standardized protocols. Data were statistical analyzed. Logistic regression models was used to estimate odds ratios and 95% confidence intervals for use of analgesics and psychotropic drugs in the cohorts of 2001 and 2007, controlling for age, gender, education and cognition. Results shows that the prevalence of medication use and polypharmacy in older adults has increased dramatically the late 1980s to the 2000s in central Stockholm, Sweden. In particular, the use of analgesics increased significantly, while some drug groups decreased, i.e., antipsychotics. Women used more medication than men in all three cohorts. Older adults living in service buildings used the largest amount of drugs in 1987, whereas those living in institutions were the most frequent users in 2001 and 2007. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Karolinska prostatectomy: a robot-assisted laparoscopic radical prostatectomy technique.

Science.gov (United States)

Nilsson, Andreas E; Carlsson, Stefan; Laven, Brett A; Wiklund, N Peter

2006-01-01

The last decade has witnessed an increasing trend towards minimally invasive management of prostate cancer, including laparoscopic and, more recently, robot-assisted laparoscopic prostatectomy. Several different laparoscopic approaches have been continuously developed during the last 5 years and it is still unclear which technique yields the best outcome. We present our current technique of robot-assisted laparoscopic radical prostatectomy. The technique described has evolved during the course of >400 robotic prostatectomies performed by the robotic team since the robot-assisted laparoscopic radical prostatectomy program was introduced at Karolinska University Hospital in January 2002. Our procedure comprises several modifications of previously reported ones, and we utilize fewer robotic instruments to reduce costs. An extended posterior dissection is performed to aid in the bladder neck-sparing dissection. In nerve-sparing procedures the vesicles are divided to avoid damage to the erectile nerves. In order to preserve the apical anatomy the dorsal venous complex is incised sharply and is first over-sewn after the apical dissection is completed. Our technique enables a more fluent dissection than previously described robotic techniques. Minimizing changes of instruments and the camera not only cuts costs but also reduces inefficient operating maneuvers, such as switching between 30 degrees and 0 degrees lenses during the procedure. We present a technique which in our hands has achieved excellent functional and oncological results.

Dental erosion, prevalence and risk factors among a group of adolescents in Stockholm County.

Science.gov (United States)

Skalsky Jarkander, M; Grindefjord, M; Carlstedt, K

2018-02-01

To investigate the prevalence and risk factors of dental erosion (DE) among a group of adolescents in Stockholm County. This cross sectional cohort study was conducted at three clinics of the Public Dental Service in Stockholm County. Fifteen and 17 year old adolescents (1335) who scheduled their regular dental health examination were asked to participate. After drop-outs a sample of 1071 individuals, 547 males and 524 females were enrolled in the study. Presence of erosive wear was diagnosed (yes/no) on marker teeth by trained dentists/dental hygienists and photographs were taken. The adolescents answered a questionnaire regarding oral symptoms, dietary and behavioural factors. Two calibrated specialist dentists performed evaluation of the photographs for severity of DE using a modified version of the Simplified Erosion Partial Recording System (SEPRS). DE was clinically diagnosed in 28.3% of 15 years old and 34.3% of 17 years old. Severe erosive wear (grade 3 and 4 according to SEPRS) was found in 18.3% of the adolescents based upon the intra-oral photographs. DE was more prevalent and severe among males than females. Clinically diagnosed erosive lesions correlated significantly with soft drink consumption (p < 0.001), the use of juice or sport drinks as a thirst quencher after exercise (p = 0.006) and tooth hypersensitivity when eating and drinking (p = 0.012). Furthermore, self-assessed gastric reflux was a factor strongly associated with DE (p < 0.001). The study indicated that DE was common among adolescents in Stockholm County and associated with both internal and external risk factors.

Sorafenib inhibits tumor growth and vascularization of rhabdomyosarcoma cells by blocking IGF-1R-mediated signaling

Directory of Open Access Journals (Sweden)

Wessen Maruwge

2008-11-01

Full Text Available Wessen Maruwge1, Pádraig D’Arcy1, Annika Folin1,2, Slavica Brnjic1, Johan Wejde1, Anthony Davis1, Fredrik Erlandsson3, Jonas Bergh1,2, Bertha Brodin11Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden; 2Radiumhemmet, Karolinska University Hospital, Stockholm, Sweden; 3Bayer Pharmaceutical Corporation, SwedenAbstract: The growth of many soft tissue sarcomas is dependent on aberrant growth factor signaling, which promotes their proliferation and motility. With this in mind, we evaluated the effect of sorafenib, a receptor tyrosine kinase inhibitor, on cell growth and apoptosis in sarcoma cell lines of various histological subtypes. We found that sorafenib effectively inhibited cell proliferation in rhabdomyosarcoma, synovial sarcoma and Ewing’s sarcoma with IC50 values <5 µM. Sorafenib effectively induced growth arrest in rhabdomyosarcoma cells, which was concurrent with inhibition of Akt and Erk signaling. Studies of ligand-induced phosphorylation of Erk and Akt in rhabdomyosarcoma cells showed that insulin-like growth factor-1 is a potent activator, which can be blocked by treatment with sorafenib. In vivo sorafenib treatment of rhabdomyosarcoma xenografts had a significant inhibitory effect on tumor growth, which was associated with inhibited vascularization and enhanced necrosis in the adjacent tumor stroma. Our results demonstrate that in vitro and in vivo growth of rhabdomyosarcoma can be suppressed by treatment with sorafenib, and suggests the possibilities of using sorafenib as a potential adjuvant therapy for the treatment of rhabdomyosarcoma.Keywords: soft tissue sarcoma, kinase inhibitors, targeted therapy, vascularization

Replication of endometriosis-associated single-nucleotide polymorphisms from genome-wide association studies in a Caucasian population.

Science.gov (United States)

Sundqvist, J; Xu, H; Vodolazkaia, A; Fassbender, A; Kyama, C; Bokor, A; Gemzell-Danielsson, K; D'Hooghe, T M; Falconer, H

2013-03-01

Is it possible to replicate the previously identified genetic association of four single-nucleotide polymorphisms (SNPs), rs12700667, rs7798431, rs1250248 and rs7521902, with endometriosis in a Caucasian population? A borderline association was observed for rs1250248 and endometriosis (P = 0.049). However, we could not replicate the other previously identified endometriosis-associated SNPs (rs12700667, rs7798431 and rs7521902) in the same population. Endometriosis is considered a complex disease, influenced by several genetic and environmental factors, as well as interactions between them. Previous studies have found genetic associations with endometriosis for SNPs at the 7p15 and 2q35 loci in a Caucasian population. Allele frequencies of SNPs were investigated in patients with endometriosis and controls. Blood samples and peritoneal biopsies were taken from a Caucasian female population consisting of 1129 patients with endometriosis and 831 controls. DNA was extracted for genotyping. The study was performed at a University hospital and research laboratories. A weak association with endometriosis (all stages) was observed for rs1250248 (P = 0.049). No significant associations were observed for the SNPs rs12700667, rs7798431 and rs7521902. A non-significant trend towards the association of rs1250248 with moderate/severe endometriosis was observed (odds ratio 1.18, 95% confidence interval 0.97-1.44). The inability to confirm all previous findings may result from differences between populations and type II errors. Our result demonstrates the difficulty of identifying common genetic variants in complex diseases. This study was supported by grants from the Karolinska Institutet and Stockholm City County/Karolinska Institutet (ALF), Stockholm, Sweden, Swedish Medical Research Council (K2007-54X-14212-06-3, K2010-54X-14212-09-3), Stockholm, Sweden, Leuven University Research Council (Onderzoeksraad KU Leuven), the Leuven University Hospitals Clinical Research Foundation

Stockholm conference. Summary of the international conference on the security of material in Stockholm, Sweden

International Nuclear Information System (INIS)

Hoskins, Richard

2001-01-01

Preventing illicit uses of nuclear material and radioactive sources was a major international concern even before the spectre of nuclear terrorism was raised by terrorist attacks in September 2001. At an IAEA international conference in Stockholm, Sweden, convened in May 2001, international experts examined ways and means of strengthening systems for the protection of nuclear and radioactive material. The Conference - formally called 'Security of Material: Measures to Prevent, Intercept and Respond to Illicit Uses of Nuclear Material and Radioactive Sources' - was attended by more than 300 experts from around the world. It was organized by the IAEA in cooperation with the European Police Office (Europol), the International Criminal Police Organization - Interpol (ICPO-Interpol), and the World Customs Organization (WCO), and hosted by the Swedish Nuclear Power Inspectorate. In the Conference Summary Document, participants underscored the importance of establishing stronger systems for nuclear security, and they outlined a number of steps for the future in particular areas. Following are excerpts from the Document. More information on the Conference is accessible on the IAEA's WorldAtom Web site at http://www.iaea.org/ worldatom/Press/P r elease/2001/ prn0110.shtml

HCH contamination from former pesticide production in Brazil--a challenge for the Stockholm Convention implementation.

Science.gov (United States)

Torres, J P M; Fróes-Asmus, C I R; Weber, R; Vijgen, J M H

2013-04-01

Hexachlorocyclohexane (HCH) isomers (α-, β- and γ- HCH [lindane]) were recently added to the list of persistent organic pollutants regulated by the Stockholm Convention, and therefore, the legacy of HCH and lindane production has become an issue of global relevance. The production of lindane with the much larger quantities of associated waste isomers has generated large waste deposits and contaminated sites. This article presents an overview of HCH-polluted sites in Brazil as a basis for further activities related to the Stockholm Convention. The locations of HCH stockpiles and contaminated sites in Brazil arising from production and formulation have been compiled and mapped. This shows that the measures taken over the past 25 years have not resulted in remediation of the HCH pollution. An exposure risk study has been summarised for one major site and is included to demonstrate the contemporary relevance of the contamination. Major site remediation efforts are planned at one site but people live close to several other sites, and there is an urgent need of further assessments and remediation to ensure the protection of human health and the environment. The Stockholm Convention requires a systematic approach and should be adopted for the assessment of all sites and appropriate isolation/remediation measures should be facilitated. The appropriate planning of these activities for the production site in Rio de Janeiro could be a positive contribution for Rio+20 highlighting that green economy and sustainable production also include the appropriate management of legacies of historic production of an industrial sector (here the organochlorine industry).

Stockholm Safety Conference. Analysis of the sessions on radiological protection, licensing and risk assessment

International Nuclear Information System (INIS)

Gea, A.

1981-01-01

A summary of the sessions on radiological protection, licensing and risk assessment in the safety conference of Stockholm is presented. It is considered the new point of view of the nuclear safety, probabilistic analysis, components failures probability and accident analysis. They are included conclusions applicable in many cases to development countries. (author)

Understanding healthcare innovation systems: the Stockholm region case.

Science.gov (United States)

Larisch, Lisa-Marie; Amer-Wåhlin, Isis; Hidefjäll, Patrik

2016-11-21

Purpose There is an increasing interest in understanding how innovation processes can address current challenges in healthcare. The purpose of this paper is to analyze the wider socio-economic context and conditions for such innovation processes in the Stockholm region, using the functional dynamics approach to innovation systems (ISs). Design/methodology/approach The analysis is based on triangulation using data from 16 in-depth interviews, two workshops, and additional documents. Using the functional dynamics approach, critical structural and functional components of the healthcare IS were analyzed. Findings The analysis revealed several mechanisms blocking innovation processes such as fragmentation, lack of clear leadership, as well as insufficient involvement of patients and healthcare professionals. Furthermore, innovation is expected to occur linearly as a result of research. Restrictive rules for collaboration with industry, reimbursement, and procurement mechanisms limit entrepreneurial experimentation, commercialization, and spread of innovations. Research limitations/implications In this study, the authors analyzed how certain functions of the functional dynamics approach to ISs related to each other. The authors grouped knowledge creation, resource mobilization, and legitimacy as they jointly constitute conditions for needs articulation and entrepreneurial experimentation. The economic effects of entrepreneurial experimentation and needs articulation are mainly determined by the stage of market formation and existence of positive externalities. Social implications Stronger user involvement; a joint innovation strategy for healthcare, academia, and industry; and institutional reform are necessary to remove blocking mechanisms that today prevent innovation from occurring. Originality/value This study is the first to provide an analysis of the system of innovation in healthcare using a functional dynamics approach, which has evolved as a tool for public

The Stockholm-3 (STHLM3) Model can Improve Prostate Cancer Diagnostics in Men Aged 50-69 yr Compared with Current Prostate Cancer Testing.

Science.gov (United States)

Eklund, Martin; Nordström, Tobias; Aly, Markus; Adolfsson, Jan; Wiklund, Peter; Brandberg, Yvonne; Thompson, James; Wiklund, Fredrik; Lindberg, Johan; Presti, Joseph C; StLezin, Mark; Clements, Mark; Egevad, Lars; Grönberg, Henrik

2016-11-23

Prostate cancer screening is associated with low specificity, unnecessary biopsies, and overdiagnosis. We have previously shown that the Stockholm-3 model (S3M) can reduce biopsies compared with using prostate-specific antigen (PSA) ≥3ng/ml as an indication for biopsy. Urologists in today's current prostate cancer testing (CPT) have access to numerous variables in addition to PSA (eg, age, ethnicity, family history, free PSA, PSA velocity, digital rectal examination, and prostate volume) to support biopsy decisions. We estimated the number of prostate cancers diagnosed and prostate biopsies performed if S3M replaced CPT in Stockholm, Sweden, by comparing biopsy results in 56 282 men who underwent PSA testing according to CPT in Stockholm in 2011 with the 47 688 men enrolled in the STHLM3 validation cohort 2012-2015. With the same sensitivity as CPT to diagnose Gleason score ≥7 prostate cancer, S3M was estimated to reduce the number of men biopsied by 53% (95% confidence interval [CI]: 41-65%), avoid 76% (95% CI: 67-81%) of negative biopsies, and reduce Gleason score 6 cancers by 23% (95% CI: 6-40%). S3M has the potential to improve prostate cancer diagnostics by better selecting men with high risk of GS ≥7 prostate cancer. We modeled the effect the Stockholm-3 model would have on prostate cancer diagnostics if it replaced current clinical practice. We found that Stockholm-3 model may substantially reduce the number of biopsies, while maintaining the same sensitivity to diagnose clinically significant prostate cancer. Copyright © 2016. Published by Elsevier B.V.

Foreign Reports about Stepan Razin’s Execution. New Documents from the Stockholm Archive

Directory of Open Access Journals (Sweden)

Gleb M. Kazakov

2017-12-01

Full Text Available This paper analyzes reports written by foreign authors about the execution of Stepan Razin. The main focus is on two dispatches written by the Swedish citizen and merchant in Moscow, Christoff Koch, in May–June 1671 and sent to Narva, and from there, they were forwarded to the Swedish capital, among other places. They are now kept at the State Archives in Stockholm, and they have not been discussed previously in the scholarly literature. The paper contains the full translation into Russian of two long reports written by Koch about Razin’s capture, delivery to Moscow, interrogation, and execution, with our comments. Special attention is given to a unique colored drawing, showing the brothers, Stepan and Frol Razin, as well as the body parts of the executed Stepan. From the written documents it becomes clear that the drawing was sent from Moscow to the governor of Swedish Ingria in Narva, and then forwarded to Stockholm, together with the two Koch dispatches. The authors come to the conclusion that several copies must have been made and that they were intentionally distributed among foreigners in Moscow. Most probably only one copy has survived to our days, the one in Stockholm. Arguments are given for the hypothesis that one copy of the drawing ended up in England and served as the prototype for the well-known imprint of 1672, which shows the Razin brothers when they were being delivered to Moscow. In our study we also compare the information given by Koch with descriptions of Razin’s death that were published in West-European newspapers, pamphlets, and books during the 1670s. This comparison brings us to the conclusion that the information about the execution of the leader of the rebellion reached the European press from several witnesses to the events, and that, over time, the original information was filled out with invented details.

Normative data on the diurnal pattern of the Karolinska Sleepiness Scale ratings and its relation to age, sex, work, stress, sleep quality and sickness absence/illness in a large sample of daytime workers.

Science.gov (United States)

Åkerstedt, Torbjorn; Hallvig, David; Kecklund, Göran

2017-10-01

Self-rated sleepiness responds to sleep loss, time of day and work schedules. There is, however, a lack of a normative reference showing the diurnal pattern during a normal working day, compared with a day off, as well as differences depending on stress, sleep quality, sex, age and being sick listed. The present study sought to provide such data for the Karolinska Sleepiness Scale. Participants were 431 individuals working in medium-sized public service units. Sleepiness (Karolinska Sleepiness Scale, scale 1-9) was rated at six times a day for a working week and 2 days off (>90.000 ratings). The results show a clear circadian pattern, with high values during the morning (4.5 at 07:00 hours) and evening (6.0 at 22:00 hours), and with low values (3-4) during the 10:00-16:00 hours span. Women had significantly higher (0.5 units) Karolinska Sleepiness Scale values than men, as did younger individuals (0.3 units), those with stress (1.3 units above the low-stress group) and those with poor sleep quality (1.0 units above those with qood sleep quality). Days off showed reduced sleepiness (0.7 units), while being sick listed was associated with an increased sleepiness (0.8 units). Multiple regression analysis of mean sleepiness during the working week yielded mean daytime stress, mean sleep quality, age, and sex as predictors (not sleep duration). Improved sleep quality accounted for the reduced sleepiness during days off, but reduced stress was a second factor. Similar results were obtained in a longitudinal mixed-model regression analysis across the 7 days of the week. The percentage of ratings at Karolinska Sleepiness Scale risk levels (8 + 9) was 6.6%, but most of these were obtained at 22:00 hours. It was concluded that sleepiness ratings are strongly associated with time of day, sleep quality, stress, work day/day off, being ill, age, and sex. © 2017 European Sleep Research Society.

Validation of the model of Critical Heat Flux COBRA-TF compared experiments of Post-Dryout performed by the Royal Institute of Technology (KTH); Validacion del Modelo de Critical Heat Flux de COBRA-TF frente a los Experimentos de Post-Dryout realizados por el Royal Institute of Technology (KTH)

Energy Technology Data Exchange (ETDEWEB)

Abarca, A.; Miro, R.; Barrachina, T.; Verdu, G.

2014-07-01

In this work is a validation of the results obtained with different existing correlations for predicting the value and location of the CTF code CHF, using them for experiments of Post-Dryout conducted by the Royal Institute of Technology (KTH) in Stockholm, Sweden. (Author)

Musculoskeletal pain: prescription of NSAID and weak opioid by primary health care physicians in Sweden 2004–2008 – a retrospective patient record review

Directory of Open Access Journals (Sweden)

Metha Brattwall

2010-08-01

Full Text Available Metha Brattwall1, Ibrahim Turan2, Jan Jakobsson31Department of Anaesthesia, Institute for Clinical Sciences at Sahlgrenska Academy, Mölndal Hospital, Gothenburg, Sweden; 2Foot and Ankle Surgical Centre, Stockholm, Sweden; 3Karolinska Institutet, Institution for Physiology and Pharmacology, Department of Anaesthesia, Stockholm, SwedenPurpose: To study the prescription of oral analgesics for musculoskeletal pain by primary care physicians over a 5-year period in Sweden.Design: A retrospective automatic database review of patient records at four primary health care centers. All prescriptions of NSAIDs, weak opioids, and coprescriptions of gastroprotecting medications to patients with musculoskeletal were retrieved for the period January 1, 2004 to November 11, 2008.Results: A total of 27,067 prescriptions prescribed to 23,457 patients with musculoskeletal pain were analyzed. Of all prescriptions, NSAIDs were the most commonly prescribed analgesic comprising 79%, tramadol was the second most commonly prescribed analgesic comprising 9%, codeine the third most (7%, and dextropropoxyphene the fourth (5%. The proportion of NSAIDs and weak opioids and the proportion of the different weak opioids prescribed showed no change over time. The proportion of nonselective and selective NSAIDs prescribed changed; Coxib prescriptions decreased from 9% to 4% of all analgesics prescribed in 2004–2007 with no change in 2008.Conclusion: NSAIDs were found to be the dominant class of analgesic prescribed by primary care physicians to patients diagnosed as musculoskeletal pain. No change was observed in the proportion of NSAID and weak opioid prescription over the period studied. Prescription of selective Coxibs decreased and was less than 4% in 2008. The impact on gastrointestinal and cardiovascular adverse effects associated with the extensive prescription of NSAIDS for musculoskeletal pain warrants further analysis.Keywords: nonsteroidal anti-inflammatory drugs

Sexual activity as a trigger of myocardial infarction. A case-crossover analysis in the Stockholm Heart Epidemiology Programme (SHEEP)

DEFF Research Database (Denmark)

Möller, J; Ahlbom, A; Hulting, J

2001-01-01

.9). CONCLUSIONS: The increased risk of myocardial infarction after sexual activity and the further increase in risk among the less physically fit support the hypothesis of causal triggering by sexual activity. However, the absolute risk per hour is very low, and exposure is relatively infrequent. Thus having sex......OBJECTIVE: To investigate sexual activity as a trigger of myocardial infarction and the potential effect modification of physical fitness. DESIGN: A case-crossover study nested in the Stockholm Heart Epidemiology Programme (SHEEP). SETTING: Stockholm County from April 1993 to December 1994...... once a week only increases the annual risk of myocardial infarction slightly. Counselling should focus on encouraging patients to live a physically active life and not on abstaining from sexual activity....

Letter to the editor

Directory of Open Access Journals (Sweden)

Linde A

2016-08-01

Full Text Available Annika Linde, Amelie Plymoth Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden It was with great interest that we noticed that other researchers are also interested in participant-collected nasal swabs to detect pathogens in acute respiratory infections, and we welcome the findings presented in the study by Vargas et al.1        Of importance is that already in the beginning of 2015, we showed in our research work that nasal self-sampling is feasible in large-scale surveillance of respiratory infections.2  View the original paper by Vargas and colleagues. 

The Gazprom-Naftogaz Stockholm Arbitration Awards. Time for Settlements and Responsible Behaviour

International Nuclear Information System (INIS)

Eyl-Mazzega, Marc-Antoine

2018-01-01

The signing in January 2009 of the gas supply and transit contracts between Gazprom and Naftogaz marked a turning point in Russian-Ukrainian gas relations: yearly intergovernmental, last minute and non-transparent winter deals were replaced by a predictable, long term commercial relationship. Naftogaz quickly turned into Gazprom's most profitable customer, taking the largest gas volumes at the Russian border and paying a higher price than German customers for example,[1] while Naftogaz obtained a satisfying gas transit tariff. At least, the January 2009 gas crisis had resulted in this key improvement for the security of Ukrainian and European gas supplies. Yet almost ever since then, the contract terms had been disputed as the Ukrainian economy could no more afford the high gas prices, the high mandatory yearly purchase volumes and as transit volumes were below contract provisions especially when the Nord Stream pipeline was commissioned. Several temporary pricing or flexibility arrangements in the form of political or patronage-type concessions had been made under President Yanukovych. But following the 2014 regime change in Ukraine and payment arrears by Naftogaz, Gazprom sought to recover unpaid debts and the new reform and business-minded Naftogaz management filed a case at the Arbitration Institute of the Stockholm Chamber of Commerce (hereafter, the Institute) as the parties did not agree on a review of the contract terms. Claims and counter claims quickly reached sky high levels, leading to the most sensitive European gas arbitration involving Gazprom. Mutual claims amounted to about USD 125 billion and had the potential to bankrupt both Gazprom and Naftogaz. At the same time, Gazprom and Naftogaz proved responsible in agreeing to winter package agreements brokered by the European Commission that enabled continued temporary Russian gas exports to Ukraine and safe transit to Europe. Following four years of procedure, the Institute has finally made two

[The man on the portrait].

Science.gov (United States)

Bergstrand, A

1996-01-01

Marie Curie was awarded the Nobel Prize in chemistry 1911. During the preceding year a rumour had circulated in Stockholm that she had had an affaire with one of her assistants. She received a letter, in which she was told that there had been strong opposition to her election not on scientific but moral grounds, and that she should not go to Stockholm, because nobody could forsee what reactions her appearance at the prize ceremony could evoke. Emil Kleen, a man of violent temper and radical opinions, reacted strongly to these rumours. He wrote a paper, with a violent attack on Gustaf Retzius, previous professor of Histology at Karolinska Institutet. Rightly or wrongly he suspected him to be the author of the infamous letter. Retzius is described as a dilletant in scientific matters, as a "sexual hyena" and a garroulus old man. This portrait of Retzius is of course most unfair, but the portrait of Emil Kleen by the famous swedish artist Bruno Liljefors is a masterpiece and one of the most valuable of the Swedish Medical Association.

National surveys: a way to manage treatment strategies in Parkinson's disease? Pharmaceutical prescribing patterns and patient experiences of symptom control and their impact on disease

Directory of Open Access Journals (Sweden)

Skogar Ö

2013-07-01

Full Text Available Örjan Skogar,1,2 Mats Nilsson,1 Carl-Johan Törnhage,3 Johan Lökk2 1Futurum Health Care Academy, Jönköping, 2Institution of Neurobiology, Care Sciences and Society, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, 3Department of Pediatrics, Skaraborg Hospital, Skövde, Sweden Background: The purpose of this study was to draw conclusions from patient-reported experiences in two national surveys from Scandinavia with the intention of comparing treatment strategies and increasing our knowledge of factors that affect the experiences of patients with Parkinson's disease (PD. Methods: A total of 2000 individuals in Sweden and 1300 in Norway were invited to complete postal surveys covering PD-related issues. Patient experiences of diagnostic procedures, symptom control, and follow-up in PD and the effects on symptom-related quality of life were collected. Pharmaceutical prescription data on anti-PD drugs and administrative data were collected from national registries. Results: The surveys were completed by 1553 (78% of the Swedish cohort and 1244 (96% of the Norwegian cohort. Only small differences were seen in disease duration and age distribution. Statistically as well as clinically significant differences in symptom control, diagnostic, and follow-up procedures, as well as in pharmacological treatment and impact on quality of life, were found between the national cohorts independent of disease duration. Conclusion: Information from separate national surveys has the potential to increase our knowledge of patient experiences in PD and can be used to compare, evaluate, educate, and guide health care staff and administrators in optimizing health care for patients with the disease. Keywords: parkinson's disease, diagnosis, follow-up, pharmaceutical prescription, quality of life, survey

Demography, diagnostics, and medication in dementia with Lewy bodies and Parkinson's disease with dementia: data from the Swedish Dementia Quality Registry (SveDem

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Fereshtehnejad SM

2013-06-01

Full Text Available Seyed-Mohammad Fereshtehnejad,1 Dorota Religa,2,3 Eric Westman,1 Dag Aarsland,2,4 Johan Lökk,1,3 Maria Eriksdotter1,3 1Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences, and Society (NVS, Karolinska Institutet, Stockholm, Sweden; 2Alzheimer's Disease Research Center, Department of Neurobiology, Care Sciences and Society (NVS, Karolinska Institutet, Stockholm, Sweden; 3Department of Geriatric Medicine, Karolinska University Hospital, Stockholm, Sweden; 4Centre for Age-Related Diseases, Stavanger University Hospital, Stavanger, Norway Introduction: Whether dementia with Lewy bodies (DLB and Parkinson's disease with dementia (PDD should be considered as one entity or two distinct conditions is a matter of controversy. The aim of this study was to compare the characteristics of DLB and PDD patients using data from the Swedish Dementia Quality Registry (SveDem. Methods: SveDem is a national Web-based quality registry initiated to improve the quality of diagnostic workup, treatment, and care of patients with dementia across Sweden. Patients with newly diagnosed dementia of various types were registered in SveDem during the years 2007–2011. The current cross-sectional report is based on DLB (n = 487 and PDD (n = 297 patients. Demographic characteristics, diagnostic workup, Mini-Mental State Examination (MMSE score, and medications were compared between DLB and PDD groups. Results: No gender differences were observed between the two study groups (P = 0.706. PDD patients were significantly younger than DLB patients at the time of diagnosis (74.8 versus 76.8 years, respectively; P < 0.001. A significantly higher prevalence of patients with MMSE score #24 were found in the PDD group (75.2% versus 67.6%; P = 0.030. The mean number of performed diagnostic modalities was significantly higher in the DLB group (4.9 ± 1.7 than in the PDD group (4.1 ± 1.6; P< 0.001. DLB patients were more likely than PDD patients to be treated with

Komentovaný překlad: Love and Stockholm Syndrome: The Mystery of Loving an Abuser. Joe Carver, PhD. http: drjoecarver.makeswebsites.com/clients/49355/File/love_and_stockholm_syndrome.html

OpenAIRE

Vašková, Adéla

2013-01-01

This bachelor's thesis consists of a Czech translation of an article Love and Stockholm Syndrome: The Mystery of Loving an Abuser written by an american author Joseph Carver, Ph.D., and a commentary on the translation. The commentary is divided into four parts: an analysis of the source text based on the model of Christiane Nord, the translation problems and their solutions, typology of the translation shifts based on the theory of Anton Popovič and the chosen translation method.

Using a profile of a modified Brief ICF Core Set for chronic widespread musculoskeletal pain with qualifiers for baseline assessment in interdisciplinary pain rehabilitation

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Löfgren M

2013-08-01

Full Text Available Monika Löfgren,1,2 Jan Ekholm,2 Lisbet Broman,3 Philipe Njoo,1 Marie-Louise Schult1–3 1Department of Rehabilitation Medicine Stockholm, Danderyd University Hospital, Sweden; 2Karolinska Institutet, Division of Rehabilitation Medicine, Department of Clinical Sciences, Danderyd University Hospital, Stockholm, Sweden; 3Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Stockholm, Sweden Aim: To describe the use of a “workable” visual profile of function and disability, based on a modified Brief International Classification of Functioning, Disability and Health (ICF Core Set for chronic widespread pain, for initial assessments in a clinical setting of interdisciplinary pain rehabilitation teams. Method: The Brief ICF Core Set was slightly adapted to meet the needs of an interdisciplinary rehabilitation medicine team working in a university outpatient clinic and admitting patients referred from primary care. The Core Set categories were made measurable by means of eg, assessment instruments and clinical investigations. The resulting profile was given a workable shape to facilitate rapid understanding of the initial assessment outcome. Results: Individual patients showed different profiles of problems and resources, which facilitated individual rehabilitation planning. At the level of the study group, the profiles for the Core Set component Body Functions showed that most patients had severe impairment in the sensation of pain and exercise tolerance categories of function, but most had resources in the motivation and memory categories of function. Likewise, for the component Activities, most patients had limitations in lifting and carrying objects and remunerative employment, but most had resources in intimate relationships and family relationships. At first, the use of the modified Brief ICF Core Set in the team conference was rather time consuming, but after a couple of months of experience, the team assessment took

Karolinska Interpersonal Violence Scale predicts suicide in suicide attempters.

Science.gov (United States)

Jokinen, Jussi; Forslund, Kaj; Ahnemark, Ewa; Gustavsson, J Petter; Nordström, Peter; Asberg, Marie

2010-08-01

Both childhood trauma and violent behavior are important risk factors for suicidal behavior. The aim of the present study was to construct and validate a clinical rating scale that could measure both the exposure to and the expression of violence in childhood and during adult life and to study the ability of the Karolinska Interpersonal Violence Scale (KIVS) to predict ultimate suicide in suicide attempters. A total of 161 suicide attempters and 95 healthy volunteers were assessed with the KIVS measuring exposure to violence and expressed violent behavior in childhood (between 6-14 years of age) and during adult life (15 years or older). The Buss-Durkee Hostility Inventory (BDHI), "Urge to act out hostility" subscale from the Hostility and Direction of Hostility Questionnaire (HDHQ), and the Early Experience Questionnaire (EEQ) were used for validation. All patients were followed up for cause of death and a minimum of 4 years from entering in the study. Five patients who committed suicide within 4 years had significantly higher scores in exposure to violence as a child, in expressed violent behavior as an adult, and in KIVS total score compared to survivors. Suicide attempters scored significantly higher compared to healthy volunteers in 3 of the 4 KIVS subscales. There were significant correlations between the subscales measuring exposure to and expression of violent behavior during the life cycle. BDHI, Urge to act out hostility, and EEQ validated the KIVS. Exposure to violence in childhood and violent behavior in adulthood are risk factors for completed suicide in suicide attempters. Behavioral dysregulation of aggression is important to assess in clinical work. The KIVS is a valuable new tool for case detection and long-term clinical suicide prevention. Copyright 2010 Physicians Postgraduate Press, Inc.

The research group, the conference programme and academic training in safety promotion - a report of the activities at Karolinska Institutet, Sweden.

Science.gov (United States)

Hörte, Lars-Gunnar; Jansson, Bjarne; Svanström, Leif

2012-01-01

The research group was established in 1967 at Lund University and moved to Karolinska Institutet in 1980. Work began with epidemiological studies of all injuries in the local community in support of various experimental local interventions. An important element was the creation of 'surveillance systems' in healthcare. The work resulted in the establishment of a WHO Collaborating Centre and an international safety-building programme called 'Safe Communities'. In parallel, training at both master's and doctoral level and the building of a conference programme were embarked upon. The research group consists of three sections. Specific efforts are being made by some countries to address their own injury problems.

Cancer risk in relatives of patients with a primary disorder of lymphocyte cytotoxicity: a retrospective cohort study.

Science.gov (United States)

Löfstedt, Alexandra; Chiang, Samuel C C; Onelöv, Erik; Bryceson, Yenan T; Meeths, Marie; Henter, Jan-Inge

2015-12-01

Mutations in genes for perforin-dependent lymphocyte cytotoxicity are associated with haemophagocytic lymphohistiocytosis, a rare disease of severe hyperinflammation that typically becomes evident in early childhood. It has been suggested that individuals with hypomorphic biallelic mutations in genes associated with haemophagocytic lymphohistiocytosis are at increased risk of developing haematological malignancies. We aimed to assess whether relatives of patients with primary haemophagocytic lymphohistiocytosis (ie, heterozygous carriers of these mutated genes) were more likely to develop cancer. In this retrospective cohort study, we used a multigeneration registry to identify relatives (parents and grandparents) of 79 Swedish children (Karolinska Institutet Research Foundation, Stockholm County Council (ALF-project). Copyright © 2015 Elsevier Ltd. All rights reserved.

Transformations and algorithms in a computerized brain atlas

International Nuclear Information System (INIS)

Thurfjell, L.; Bohm, C.; Eriksson, L.; Karolinska Institute/Hospital, Stockholm

1993-01-01

The computerized brain atlas constructed at the Karolinska Hospital, Stockholm, Sweden, has been further developed. This atlas was designed to be employed in different fields of neuro imaging such as positron emission tomography (PET), single photon emission tomography (SPECT), computerized tomography (CT) and magnetic resonance imaging (MR). The main objectives with the atlas is to aid the interpretation of functional images by introducing anatomical information, to serve as a tool in the merging of data from different imaging modalities and to facilitate the comparisons of data from different individuals by allowing for anatomical standardization of individual data. The purpose of this paper is to describe the algorithms and transformations used in the implementation of the atlas software

Development of a refined database of relative potency estimates to facilitate better characterization of variability and uncertainty in the current mammalian TEFs for PCDDs, PCDFs, and dioxin-like PCBs

Energy Technology Data Exchange (ETDEWEB)

Haws, L. [Exponent, Austin, TX (United States); Harris, M.; Santamaria, A. [Exponent, Houston, TX (United States); Su, S. [Exponent, New York, NY (United States); Birnbaum, L.; DeVito, M. [U.S. Environmental Protection Agency, Research Triangle Park, NC (United States); Farland, W. [U.S. Environmental Protection Agency, Washington, DC (United States); Walker, N. [National Institute of Environmental Health Sciences, Research Triangle Park, NC (United States); Connor, K. [Exponent, Natick, MA (United States); Finley, B. [Exponent, Santa Rosa, CA (United States)

2004-09-15

The toxic equivalency factor (TEF) approach has been widely accepted as the most feasible and plausible method presently available for evaluating potential health risks associated with exposure to mixtures of polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and dioxin-like polychlorinated biphenyls (PCBs). In accordance with this approach, the relative potency of each congener is expressed as some fraction of the potency of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). The current TEFs for PCDDs, PCDFs, and dioxin-like PCBs were established by the World Health Organization (WHO) following the meeting of an international expert panel in June of 1997. In the course of their review, the WHO expert panel examined data from an extensive body of in vivo and in vitro studies that had been compiled into a database of relative potency (REP) values by scientists at the Karolinska Institute in Stockholm, Sweden (hereafter referred to as the Karolinska database). The WHO TEFs are currently used by numerous governmental agencies and others to regulate or otherwise assess health risks associated with exposure to PCDD/Fs and dioxin-like PCBs in foods, consumer products, and environmental media. As has been noted by others, for any given congener, the underlying REP values typically represent a heterogeneous data set, and the range of REPs often spans several orders of magnitude. It would therefore be helpful to better understand the degree to which the TEF values contribute to variability and uncertainty in the risk assessment process. As such, the goal of this project was to develop a database that will better characterize the range of REPs, allow for the development and application of quantitative weighting schemes, and facilitate quantitative analyses. This in turn will allow for better characterization of variability and uncertainty inherent in the mammalian TEFs. The development of this database was necessary since the Karolinska database was

Mid-21st century air quality at the urban scale under the influence of changed climate and emissions: case studies for Paris and Stockholm

Science.gov (United States)

Markakis, K.; Valari, M.; Engardt, M.; Lacressonnière, G.; Vautard, R.; Andersson, C.

2015-10-01

Ozone, PM10 and PM2.5 concentrations over Paris, France and Stockholm, Sweden were modeled at 4 and 1 \\unit{km} horizontal resolutions respectively for the present and 2050 periods employing decade-long simulations. We account for large-scale global climate change (RCP-4.5) and fine resolution bottom-up emission projections developed by local experts and quantify their impact on future pollutant concentrations. Moreover, we identify biases related to the implementation of regional scale emission projections over the study areas by comparing modeled pollutant concentrations between the fine and coarse scale simulations. We show that over urban areas with major regional contribution (e.g., the city of Stockholm) the bias due to coarse emission inventory may be significant and lead to policy misclassification. Our results stress the need to better understand the mechanism of bias propagation across the modeling scales in order to design more successful local-scale strategies. We find that the impact of climate change is spatially homogeneous in both regions, implying strong regional influence. The climate benefit for ozone (daily average and maximum) is up to -5 % for Paris and -2 % for Stockholm city. The joined climate benefit on PM2.5 and PM10 in Paris is between -10 and -5 % while for Stockholm we observe mixed trends up to 3 % depending on season and size class. In Stockholm, emission mitigation leads to concentration reductions up to 15 % for daily average and maximum ozone and 20 % for PM and through a sensitivity analysis we show that this response is entirely due to changes in emissions at the regional scale. On the contrary, over the city of Paris (VOC-limited photochemical regime), local mitigation of NOx emissions increases future ozone concentrations due to ozone titration inhibition. This competing trend between the respective roles of emission and climate change, results in an increase in 2050 daily average ozone by 2.5 % in Paris. Climate and not

Mid-21st century air quality at the urban scale under the influence of changed climate and emissions - case studies for Paris and Stockholm

Science.gov (United States)

Markakis, Konstantinos; Valari, Myrto; Engardt, Magnuz; Lacressonniere, Gwendoline; Vautard, Robert; Andersson, Camilla

2016-02-01

Ozone, PM10 and PM2.5 concentrations over Paris, France and Stockholm, Sweden were modelled at 4 and 1 km horizontal resolutions respectively for the present and 2050 periods employing decade-long simulations. We account for large-scale global climate change (RCP-4.5) and fine-resolution bottom-up emission projections developed by local experts and quantify their impact on future pollutant concentrations. Moreover, we identify biases related to the implementation of regional-scale emission projections by comparing modelled pollutant concentrations between the fine- and coarse-scale simulations over the study areas. We show that over urban areas with major regional contribution (e.g. the city of Stockholm) the bias related to coarse-scale projections may be significant and lead to policy misclassification. Our results stress the need to better understand the mechanism of bias propagation across the modelling scales in order to design more successful local-scale strategies. We find that the impact of climate change is spatially homogeneous in both regions, implying strong regional influence. The climate benefit for ozone (daily mean and maximum) is up to -5 % for Paris and -2 % for Stockholm city. The climate benefit on PM2.5 and PM10 in Paris is between -5 and -10 %, while for Stockholm we estimate mixed trends of up to 3 % depending on season and size class. In Stockholm, emission mitigation leads to concentration reductions up to 15 % for daily mean and maximum ozone and 20 % for PM. Through a sensitivity analysis we show that this response is entirely due to changes in emissions at the regional scale. On the contrary, over the city of Paris (VOC-limited photochemical regime), local mitigation of NOx emissions increases future ozone concentrations due to ozone titration inhibition. This competing trend between the respective roles of emission and climate change, results in an increase in 2050 daily mean ozone by 2.5 % in Paris. Climate and not emission change

[The supervisor has a crucial role in the medical student's degree projects. Experiences from seven semesters at Karolinska Institutet].

Science.gov (United States)

Möller, Riitta; Shoshan, Maria; Ponzer, Sari

2015-01-13

In Sweden degree projects have a central role in evaluation of higher education, wherefore significant resources are spent on developing students' research competence. The undergraduate medical program at Karolinska Institutet introduced its degree project course in 2010. This paper gives an overview of the course and summarizes experiences from the first seven terms. In order to finalize their projects within one term, most students need substantial support. A highly structured course and frequent progress monitoring are advantageous. Other crucial factors are the quality of the supervision and students' verbal skills as well as support in scientific writing. In addition, increased awareness of the learning outcomes already at the beginning of the course may help students to achieve the expected results. Finally, students need to recognize their own responsibility for learning. 

Life and Death in the City: Demography and Living Standards during Stockholm's Industrialization

DEFF Research Database (Denmark)

Molitoris, Joseph John

2015-01-01

’s intergenerational social mobility, and infant and child mortality during Stockholm’s industrialization and fertility transition. The results of this work challenge many existing explanations of the fertility decline and reveal how, despite overall improvements in living standards, elite socioeconomic groups were......This dissertation uses longitudinal micro-data from Stockholm between 1878 and 1926 to study the causes and consequences of the fertility transition and to examine the development of living standards inequality during industrialization. Although both processes have received much interest from...... able to continually leverage their superior resources to maintain significantly lower levels of infant and child mortality....

Immunohistochemical analysis of cannabinoid receptor 1 expression in steatotic rat livers.

Science.gov (United States)

Zduniak, Krzysztof; Ziółkowski, Piotr; Regnell, Pontus; Tollet-Egnell, Petra; Åkesson, Lina; Cooper, Martin E

2016-04-01

The primary aim of the present study was to determine the expression levels of cannabinoid receptor type 1 (CB1) in steatotic rat livers. The secondary aim was to clarify whether steatosis and inflammation are more marked in areas with increased CB1 overexpression. For ethical and economic reasons, the present study investigated tissue from archived liver blocks, which were obtained from 38 rats that had been euthanized during the course of previous research at the Karolinska Institute of the Karolinska University Hospital (Stockholm, Sweden) and Lund University (Malmö, Sweden). Liver tissue fixed in formalin and embedded in paraffin was used that had been sourced from 36 male Sprague Dawley rats (age, 7 weeks) and 2 rats (age, 180 days) lacking normal leptin receptors. The rat liver tissue was stained with antibodies against CB1 and counterstained with hematoxylin. The expression of CB1 and the number of cells overexpressing CB1 were determined. Steatosis was scored according to the Dixon scoring system. CB1 overexpression and steatosis were detected in hepatocytes from all 38 livers sampled. The expression of CB1 was more marked in hepatocytes localized next to portal triads. Near the central veins, the expression was significantly weaker. Steatosis was more marked in areas of increased CB1 overexpression. Lymphocyte infiltration was more commonly observed in areas of increased CB1 overexpression. Therefore, the present results indicate that CB1 receptors are overexpressed in areas with steatosis, and indicate that CB1 in hepatocytes contributes to the formation of steatosis in rats, even prior to its progression to steatohepatitis. These results are consistent with publications reporting that CB1 in hepatocytes increases lipogenesis and contributes to inflammation.

Solubility and Potential Mobility of Heavy Metals in Two Contaminated Urban Soils from Stockholm, Sweden

International Nuclear Information System (INIS)

Oborn, Ingrid; Linde, Mats

2001-01-01

The solubility and potential mobility of heavy metals (Cd, Cu,Hg, Pb and Zn) in two urban soils were studied by sequential and leaching extractions (rainwater). Compared to rural (arable) soils on similar parent material, the urban soils were highly contaminated with Hg and Pb and to a lesser extent also with Cd,Cu and Zn. Metal concentrations in rainwater leachates were related to sequential extractions and metal levels reported from Stockholm groundwater. Cadmium and Zn in the soils were mainly recovered in easily extractable fractions, whereas Cu and Pb were complex bound. Concentrations of Pb in the residual fraction were between two- and eightfold those in arable soils, indicating that the sequential extraction scheme did not reflect the solid phases affected by anthropogenic inputs. Cadmium and Zn conc. in the rainwater leachates were within the range detected in Stockholm groundwater, while Cu and Pb conc. were higher, which suggests that Cu and Pb released from the surface soil were immobilised in deeper soil layers. In a soil highly contaminated with Hg, the Hg conc. in the leachate was above the median concentration, but still 50 times lower than the max concentration found in groundwater, indicating the possibility of other sources. In conclusion, it proved difficult to quantitatively predict the mobility of metals in soils by sequential extractions

Prevalence of Autism in Children of Somali Origin Living in Stockholm: Brief Report of an At-Risk Population

Science.gov (United States)

Barnevik-Olsson, Martina; Gillberg, Christopher; Fernell, Elisabeth

2010-01-01

This work was a follow-up study (birth years 1999-2003) of the prevalence of autism in children of Somali background living in the county of Stockholm, Sweden. In a previous study (birth years 1988-98), the prevalence of autism associated with learning disability was found to be three to four times higher among Somali children compared with other…

Planning the Green Walkable City: Conceptualizing Values and Conflicts for Urban Green Space Strategies in Stockholm

Directory of Open Access Journals (Sweden)

Hélène Littke

2015-08-01

Full Text Available Urban green spaces are essential elements of cities, contributing to the quality of life in numerous ways. However, densification strategies create a complex relationship between urban development and the quality, as well as the quantity, of urban green space. This paper examines the Green Walkable City Programme in Stockholm, a document developed to supplement the comprehensive plan as a strategic backbone for green urban planning. Based on interviews and content analysis, this paper identifies and discusses concerns raised in the development of the planning programme, and addresses the importance of urban green space for citizens’ well-being. The new comprehensive plan has introduced a shift in the attitude towards the urban green space in Stockholm. The need for urban growth is used to justify development of green fields, and a focus on the quality, rather than the quantity, of urban green space is promoted. Despite this progress, the public requests definitions for this quality approach and fears that nature within the city will be “parkified”. Therefore, this paper offers a critical reflection on the role of the Green Walkable City Programme, its situation within the context of Swedish green urban planning, and various areas of concern that have been highlighted.

Early attempts to visualize cortical monoamine nerve terminals.

Science.gov (United States)

Hökfelt, Tomas

2016-08-15

The Falck-Hillarp, formaldehyde fluorescence method for the demonstration of monoamine neurons in a microscope was established in Lund, Sweden and published in 1962. In the same year Hillarp moved to Karolinska Institutet in Stockholm. Two years later Dahlström and Fuxe published the famous supplement in Acta Physiologica Scandinavica, describing the distribution of the dopamine, noradrenaline and serotonin cell groups in the rat brain. This landmark paper also represented an important contribution to an emerging discipline in neuroscience - chemical neuroanatomy. During the following years several modifications of the original method were developed, attempting to solve some shortcomings, one being the reproducible demonstration of noradrenaline nerve terminals in cortical regions. One result was the paper focused on in the present article, which also describes other efforts in the same direction going on in parallel, primarily, in Lund and Stockholm. As a result there was, in the mid 1970s, a fairly complete knowledge of the catecholamine systems in the rat brain. This article is part of a Special Issue entitled SI:50th Anniversary Issue. Copyright © 2016 Elsevier B.V. All rights reserved.

The emergence of a post-industrial music economy? : Music and ICT synergies in Stockholm, Sweden.

OpenAIRE

Power, Dominic; Jansson, Johan

2004-01-01

Research into the music industry has for a long time been almost exclusively dominated by a focus on the production of albums and songs. In recent years, however, cities such as Stockholm have seen the growth of a profitable and varied music services industry producing everything from remixes to music marketing strategies. Standing at the forefront of this growth industry are a large number of firms attempting to combine in innovative ways music and ICT. This can take a variety of forms, for ...

[Jan Kusberg, Kleine Geschichte St. Petersburgs. (Regensburg, 2009) ; Ingrid Bohn. Kleine Geschichte Stockholms. (Regensburg, 2008) ; Konrad Dittrich. Kleine Lübecker Stadtgeschichte. (Regensburg, 2007)] / Dennis Hortmuth

Index Scriptorium Estoniae

Hormuth, Dennis

2011-01-01

Arvustus: Jan Kusberg, Kleine Geschichte St. Petersburgs. (Regensburg, 2009) ; Ingrid Bohn. Kleine Geschichte Stockholms. (Regensburg, 2008) ; Konrad Dittrich. Kleine Lübecker Stadtgeschichte. (Regensburg, 2007)

Biological and chemical characterization of harbour sediments from the Stockholm area

Energy Technology Data Exchange (ETDEWEB)

Eklund, Britta; Elfstroem, Maria; Bengtsson, Bengt-Erik; Breitholtz, Magnus [Dept. of Applied Environmental Science (ITM), Stockholm Univ. (Sweden); Gallego, Irene [Granada Univ. (Spain)

2010-01-15

Purpose: The main objective of the current study was to assess the impact of pleasure boat activities on harbour sediment quality in the Stockholm area. Sediment contamination is a growing ecological issue, and there is consequently a need to use sediment bioassays in combination with chemical analysis to determine the impact on the ecosystem. To generate sediment toxicity data relevant for the Baltic Sea, a secondary objective was to further develop and evaluate two well-established bioassays for saltwater, with the macroalga Ceramium tenuicorne and the crustacean Nitocra spinipes, to be useful also for toxicity testing of whole sediment. A major concern has been to minimize any manipulation of the sediments. A third objective was to assess whether a simple leaching procedure could be used to simulate sediment toxicity by comparing results from whole sediment and leachate tests. Materials and methods: Surface sediments (0-2 cm) from five different types of pleasure boat harbours were collected. Chemical measurements of boat related compounds, i.e. tin organic substances (tributyltin (TBT), dibutyl tin, and monobutyl tin), polyaromatic hydrocarbons (PAHs), copper, zinc, lead, tin and irgarol were conducted. The sediments were tested for toxic effects using the established Microtox {sup registered} test as well as the developed sediment tests with C. tenuicorne and N. spinipes. The endpoints are growth inhibition for the algal test and for the crustacean test mortality of larvae and rate of development expressed as the ratio between nauplia and copepodites. Two different procedures have been compared with both organisms, i.e. exposure to whole sediment and to leachate. The duration of both tests is around 1 week. Results and discussion: All harbour locations were more or less heavily contaminated with remnants from use of antifouling paints. The sediment in a smaller marina (ca. 250 boats) contained the highest levels of TBT (max 1,400 {mu}g/kg dry weight (dw

Structures of the major capsid proteins of the human Karolinska Institutet and Washington University polyomaviruses.

Science.gov (United States)

Neu, Ursula; Wang, Jianbo; Macejak, Dennis; Garcea, Robert L; Stehle, Thilo

2011-07-01

The Karolinska Institutet and Washington University polyomaviruses (KIPyV and WUPyV, respectively) are recently discovered human viruses that infect the respiratory tract. Although they have not yet been linked to disease, they are prevalent in populations worldwide, with initial infection occurring in early childhood. Polyomavirus capsids consist of 72 pentamers of the major capsid protein viral protein 1 (VP1), which determines antigenicity and receptor specificity. The WUPyV and KIPyV VP1 proteins are distant in evolution from VP1 proteins of known structure such as simian virus 40 or murine polyomavirus. We present here the crystal structures of unassembled recombinant WUPyV and KIPyV VP1 pentamers at resolutions of 2.9 and 2.55 Å, respectively. The WUPyV and KIPyV VP1 core structures fold into the same β-sandwich that is a hallmark of all polyomavirus VP1 proteins crystallized to date. However, differences in sequence translate into profoundly different surface loop structures in KIPyV and WUPyV VP1 proteins. Such loop structures have not been observed for other polyomaviruses, and they provide initial clues about the possible interactions of these viruses with cell surface receptors.

Dating human DNA with the 14C bomb peak

Energy Technology Data Exchange (ETDEWEB)

Kutschera, Walter; Liebl, Jakob; Steier, Peter [VERA Laboratory, University of Vienna, Vienna (Austria)

2013-07-01

In 1963 the limited nuclear test ban treaty stopped nuclear weapons testing in the atmosphere. By then the addition from bomb-produced {sup 14}C had doubled the {sup 14}C content of the atmosphere. Through the CO{sub 2} cycle this excess exchanged with the hydrosphere and biosphere leading to a rapidly decreasing {sup 14}C level in the atmosphere. Today we are almost back to the pre-nuclear level. As a consequence all people on Earth who lived during the second half of the 20th century were exposed to this rapidly changing {sup 14}C signal. A few years ago, a group at the Department of Cell and Molecular Biology of the Karolinska Institute in Stockholm started to use the {sup 14}C bomb peak signal in DNA to determine retrospectively the age of cells from various parts of the human body (brain, heart, fat). In a collaboration with this group, we have studied the age of olfactory bulb neurons in the human brain. For this investigation, {sup 14}C AMS measurements were developed at VERA for very small carbon samples in the range from 2 to 4 micrograms. In the presentation the general concept of {sup 14}C bomb peak dating of human DNA and several applications are discussed.

Patient Demonstration Videos in Predoctoral Endodontic Education: Aspects Perceived as Beneficial by Students.

Science.gov (United States)

Edrees, Hadeel Y; Ohlin, Johan; Ahlquist, Michael; Tessma, Mesfin K; Zary, Nabil

2015-08-01

The aim of this study was to assess the perceived benefits of video-mediated demonstrations in learning endodontics. Participants in the study were 75 third-year students enrolled in the undergraduate dentistry program at Karolinska Institute, Stockholm, Sweden. After the endodontic preclinical course, the students were introduced to the treatment protocol in the clinic by watching two live patient-demonstrated videos. The first video demonstrated how to communicate with the patient and perform diagnosis and root canal instrumentation. The second video illustrated how to perform bacterial sampling and root canal filling. After the students watched each video, a questionnaire was used to evaluate their opinions about various steps of the endodontic treatment protocol and the benefit of such educational material for their practice. Of the total 75 students, 72 completed the first questionnaire (96% response rate), and 65 completed the second questionnaire (87% response rate). The results showed that the students perceived high value in the video demonstrations related to treatment procedure. A statistically significant difference was observed between the perceived benefits of the first and second sessions in communication and treatment procedure (p<0.001). Further studies are needed to assess improvement in the design and delivery format for video demonstrations to enhance their effectiveness as a teaching modality for endodontics.

9th Transgenic Technology Meeting (TT2010) in Berlin, Germany: a meeting report.

Science.gov (United States)

Saunders, Thomas L; Sobieszczuk, Peter

2010-12-01

The first Transgenic Technology (TT) Meeting was organized in 1999 by Johannes Wilbertz, Karolinska Institute, Stockholm, Sweden as a regional meeting. The TT Meetings continued in this way, constantly gathering additional practitioners of transgenic methodologies until the breakthrough in 2005 when the 6th TT Meeting in Barcelona, Spain, hosted by Lluis Montoliu (Centro Nacional de Biotecnologia, Madrid, Spain), generated the momentum to establish the International Society for Transgenic Technologies (ISTT). Since 2006, the ISTT has continued to promote the TT Meetings and provide its membership with a forum to discuss best practices and new methods in the field. The TT2010 Meeting was held at the Max Delbrück Center for Molecular Medicine (Berlin, Germany). Participation at the TT2010 Meeting exceeded the registration capacity and set a new attendance record. Session topics included methods for the generation of rat and mouse models of human disease, fundamental and advanced topics in rodent embryonic stem cells, and the newest transgenic technologies. Short presentations from selected abstracts were of especial interest. Roundtable discussions on transgenic facility establishment and cryoarchiving of mouse lines were favorably received. Students, technical staff, and professors participated in numerous discussions and came away with practical methods and new ideas for research.

A comparison of cardiovascular risk factors for ten antipsychotic drugs in clinical practice

Directory of Open Access Journals (Sweden)

Bodén R

2013-03-01

Full Text Available Robert Bodén,1,2 Gunnar Edman,3,4 Johan Reutfors,2 Claes-Göran Östenson,3 Urban Ösby3,4 1Department of Neuroscience, Psychiatry, Uppsala University, Uppsala, Sweden; 2Department of Medicine Solna, Centre for Pharmacoepidemiology, Karolinska Institutet, Stockholm, Sweden; 3Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; 4Department of Psychiatry, Tiohundra AB, Norrtälje, Sweden Abstract: It is well known that abdominal obesity, dyslipidemia, and insulin resistance are highly prevalent in patients receiving maintenance treatment with antipsychotics, but there is limited knowledge about the association between cardiovascular risk factors and treatment with antipsychotic drugs. In this naturalistic study we investigated a sample of 809 antipsychotic-treated patients from Swedish psychosis outpatient teams. Cardiovascular risk factors (eg, metabolic syndrome, homeostasis model assessment of insulin resistance, and low-density lipoprotein values were measured, and their associations to current antipsychotic pharmacotherapy were studied. Ten antipsychotic drugs were compared in a stepwise logistic regression model. For the patients, the presence of the components of metabolic syndrome ranged from 35% for hyperglycemia to 64% for elevated waist circumference. Hypertriglyceridemia was associated with clozapine (odds ratio [OR] = 1.81, 95% confidence interval [CI] 1.08–3.04, reduced high-density lipoprotein with both clozapine and olanzapine (OR = 1.73, 95% CI 1.01–2.97; and OR = 2.03, 95% CI 1.32–3.13, hypertension with perphenazine (OR = 2.00, 95% CI 1.21–3.59, and hyperglycemia inversely with ziprasidone (OR = 0.21, 95% CI 0.05–0.89 and positively with haloperidol (OR = 2.02, 95% CI 1.18–3.48. There were no significant relationships between any of the antipsychotic drugs and increased waist circumference, homeostasis model assessment of insulin resistance, or low-density lipoprotein levels. In

Medium-to-high prevalence of screening-detected parkinsonism in the urban area of Tehran, Iran: data from a community-based door-to-door study

Directory of Open Access Journals (Sweden)

Fereshtehnejad SM

2015-02-01

Full Text Available Seyed-Mohammad Fereshtehnejad,1,2 Mahdiyeh Shafieesabet,3 Arash Rahmani,4 Ahmad Delbari,1,5 Johan Lökk1,6 1Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences, and Society (NVS, Karolinska Institutet, Stockholm, Sweden; 2Firoozgar Clinical Research Development Center (FCRDC, Firoozgar Hospital, 3Medical Student Research Committee (MSRC, Faculty of Medicine, 4Mental Health Research Center, Tehran Institute of Psychiatry, School of Behavioral Sciences and Mental Health, Iran University of Medical Sciences, Tehran, Iran; 5Iranian Research Center on Aging, University of Social Welfare and Rehabilitation, Tehran, Iran; 6Department of Geriatric Medicine, Karolinska University Hospital, Stockholm, Sweden Introduction: Parkinsonism occurs in all ethnic groups worldwide; however, there are wide variations in the prevalence rates reported from different countries, even for neighboring regions. The huge socioeconomic burden of parkinsonism necessitates the need for prevalence studies in each country. So far, there is neither data registry nor prevalence information on parkinsonism in the Iranian population. The aim of our study was to estimate the prevalence rate of probable parkinsonism in a huge urban area in Iran, Tehran using a community-based door-to-door survey.Materials and methods: We used a random multistage sampling of the households within the network of health centers consisting of 374 subunits in all 22 districts throughout the entire urban area of Tehran. Overall, 20,621 individuals answered the baseline checklist and screening questionnaire and data from 19,500 persons aged ≥30 years were entered in the final analysis. Health care professionals used a new six-item screening questionnaire for parkinsonism, which has been previously shown to have a high validity and diagnostic value in the same population.Results: A total of 157 cases were screened for parkinsonism using the validated six-item questionnaire. After

Professional autobiography of Professor Leif Svanström - with a focus on injury prevention and safety promotion.

Science.gov (United States)

Svanström, Leif

2012-01-01

Professor Svanström has spent about forty-five years in the field of Social Medicine and Health and Safety Promotion. His main lines of research and teaching are Injury Epidemiology and Safety Promotion. In the 1960s, he conducted a number of descriptive and analytical studies, and in the 1970s began to address home and occupational injuries. In 1974, he introduced the community approach to safety promotion, encapsulated in the Falköping Model, which has heavily influenced Swedish and international community safety work. Under his leadership of the Research Group on Injury Prevention and Safety Promotion at the Karolinska Institutet in Stockholm, Sweden, more than 30 doctorates have been awarded. His work as Head of the WHO Collaborating Centre on Community Safety Promotion has led to the establishment of Safe Communities worldwide.

Age at immigration and crime in Stockholm using sibling comparisons.

Science.gov (United States)

Beckley, Amber L

2015-09-01

Past Swedish research has shown that immigrants arriving in the receiving country at an older age are less likely to commit crime than immigrants arriving at a younger age. Segmented assimilation theory argues that the family and neighborhood may be important factors affecting how age at immigration and crime are related to one another. This study used population-based register data on foreign-background males from Stockholm to test the effect of age at immigration on crime. Potential confounding from the family and neighborhood was addressed using variables and modeling strategies. Initial results, using variables to control for confounding, showed that people who immigrated around age 4 were the most likely to be suspected of a crime. When controlling for unmeasured family characteristics, it seemed that a later age at immigration was tied to a lower likelihood of crime, which does not corroborate past research findings. The effect of age at immigration, however, was not statistically significant. The results imply that future research on entire families may be a worthwhile endeavor. Copyright © 2015 Elsevier Inc. All rights reserved.

Proceedings from the Fissile Material Cut-off seminar in Stockholm

International Nuclear Information System (INIS)

Arbman, G.

1998-01-01

The Swedish Defence Research Establishment hosted an international expert seminar on the subject of verifying a prohibition of the production of fissile material for nuclear weapons purpose (cut-off) in Stockholm, June 3-5 1998. The objective of the seminar was to provide an opportunity for informal discussions among scientific and technical experts on various technical matters relating to the verification of a future Fissile Material Cut-off Treaty (FMCT). A stated aim of the seminar was to keep issues of scope to a minimum. Invited speakers and commentators were given an opportunity to present their views as written contributions. The present seminar proceedings are essentially the result of these views. In addition, short summaries of the discussions following each session are included. Although an attempt was made to be as complete and accurate as possible in reproducing these discussions, the editors apologise if some important points or statements have been omitted. If so, the main reason is that the documentation of the discussions were based on written notes, not taped recordings. Eight longer contributions have been separately indexed

Proceedings from the Fissile Material Cut-off seminar in Stockholm

Energy Technology Data Exchange (ETDEWEB)

Arbman, G. [ed.

1998-07-01

The Swedish Defence Research Establishment hosted an international expert seminar on the subject of verifying a prohibition of the production of fissile material for nuclear weapons purpose (cut-off) in Stockholm, June 3-5 1998. The objective of the seminar was to provide an opportunity for informal discussions among scientific and technical experts on various technical matters relating to the verification of a future Fissile Material Cut-off Treaty (FMCT). A stated aim of the seminar was to keep issues of scope to a minimum. Invited speakers and commentators were given an opportunity to present their views as written contributions. The present seminar proceedings are essentially the result of these views. In addition, short summaries of the discussions following each session are included. Although an attempt was made to be as complete and accurate as possible in reproducing these discussions, the editors apologise if some important points or statements have been omitted. If so, the main reason is that the documentation of the discussions were based on written notes, not taped recordings. Eight longer contributions have been separately indexed.

Impact of symptomatic hypoglycemia on medication adherence, patient satisfaction with treatment, and glycemic control in patients with type 2 diabetes

Directory of Open Access Journals (Sweden)

Walz L

2014-04-01

Full Text Available Lotta Walz,1,3 Billie Pettersson,2,3 Ulf Rosenqvist,4 Anna Deleskog,3,5 Gunilla Journath,6 Per Wändell7 1Department of Oncology-Pathology, Karolinska Institutet, Stockholm, 2Center for Medical Technology Assessment, Linköping University, Linköping, 3Merck Sharp and Dohme (Sweden AB, Sollentuna, 4Department of Internal Medicine, Motala Hospital, Motala, 5Department of Molecular Medicine and Surgery, 6Department of Medicine, Karolinska Institutet, Stockholm, 7Department of Neurobiology, Care Sciences and Society, Centre for Family Medicine, Karolinska Institutet, Huddinge, Sweden Background: The purpose of this study was to evaluate the impact of symptomatic hypoglycemia on medication adherence, satisfaction with treatment, and glycemic control in patients with type 2 diabetes based on the treatment goals stated in the Swedish national guidelines. Methods: This cross-sectional, multicenter study was carried out between January and August 2009 in 430 consecutive primary health care patients on stable doses of metformin and sulfonylureas for at least 6 months. The patients completed questionnaires covering their experiences of low blood glucose and adherence, as well as barriers to and satisfaction with drug treatment (using the Treatment Satisfaction Questionnaire for Medication. Physicians collected the data from medical records. Results: Patients who experienced moderate or worse symptoms of hypoglycemia reported poorer adherence to medication (46% versus 67%; P<0.01 and were more likely to perceive barriers such as “bothered by medication side effects” (36% versus 14%; P<0.001 compared with patients with no or mild symptoms. Patients with moderate or worse symptoms of hypoglycemia were less satisfied with their treatment than those with no or mild symptoms as determined by the Treatment Satisfaction Questionnaire for Medication-Global satisfaction (67.0 versus 71.2; P<0.05. Overall, achievement of target glycated hemoglobin

In vitro viability effects on apheresis and buffy-coat derived platelets administered through infusion pumps

Directory of Open Access Journals (Sweden)

Sandgren P

2014-12-01

Full Text Available Per Sandgren,1,2 Veronica Berggren,3 Carl Westling,1,2 Viveka Stiller1 1Department of Clinical Immunology and Transfusion Medicine, Karolinska University Hospital, 2Department of Laboratory Medicine, Karolinska Institutet, 3Department of Neonatology, Karolinska University Hospital, Stockholm, SwedenBackground: Different infusion pump systems as well as gravity infusion have been widely used in neonatal transfusion. However, the limited number of published studies describing the use of infusion pumps on platelets illustrates the necessity for more robust data.Methods: To evaluate the potential in vitro effects on the cellular, metabolic, functional and phenotypic properties of platelets, we set up a four-arm paired study simultaneously comparing the use of different infusion pumps (Alaris® CC/GP with unexposed platelets. The platelet units (n=8 were either produced by the apheresis technique and suspended in 100% plasma or derived from buffy coats to yield platelet units stored in approximately 30% plasma and 70% SSP+. Fresh and 5-day old platelets were tested.Results: Regardless of the production system or storage time used, no significant differences were observed in glucose and lactate concentration, pH, adenosine triphosphate levels, response to extent of shape change, hypotonic shock response reactivity, and CD62P expression. Similarly, no differences were observed in expression of the conformational epitope on glycoprotein IIb/IIIa, determined using procaspase-activating compound 1, or in the expression of CD42b and platelet-endothelial cell adhesion molecule-1 in a comparison between platelets administered through infusion pumps versus unexposed platelets.Conclusion: Using Alaris CC/GP infusion pumps had no influence on the cellular, functional, and phenotypic in vitro properties of platelets. This fact seems not to be affected by different production systems or storage time.Keywords: platelets, neonatal platelet transfusion

Karolinska Psychodynamic Profile for Sexual Disorders: KAPP-SD. A proposal for a psychodynamic rating scale for sexual disorders.

Science.gov (United States)

Soldati, Lorenzo; Köhl, John; Abraham, Georges; Bianchi Demicheli, Francesco; Wilczek, Alexander

2015-01-01

Our first objective in this paper was to review the literature on psychodynamic rating scales of sexual disorders. Our second objective, based on the findings from our review, was to develop a psychodynamic rating scale for people with sexual disorders: the KAPP-SD. We developed the KAPP-SD by modifying an existing psychodynamic rating scale, which assesses stable modes of mental functioning and character traits, the Karolinska Psychodynamic Profile (KAPP). We removed items 13 and 14 of the KAPP and replaced them with three other items-sexual fantasies, conceptions and role of gender identity, and conceptions and role of sexual orientation. These items are part of the assessment of an individual's sexuality and are used to evaluate a person with a sexual disorder psychodynamically. The KAPP-SD, a modified version of the KAPP, can be found in the Appendix. We developed the KAPP-SD in order to help sex therapists make a rigorous psychodynamic evaluation of persons with sexual disorders, which would give information on the prognosis and on the type of treatment to offer.

A revision of existing Karolinska Sleepiness Scale responses to light: A melanopic perspective.

Science.gov (United States)

Hommes, Vanja; Giménez, Marina C

2015-01-01

A new photometric measure of light intensity that takes into account the relatively large contribution of the ipRGCs to the non-image forming (NIF) system was recently proposed. We set out to revise publications reporting on alertness scores as measured by the Karolinska Sleepiness Scale (KSS) under different light conditions in order to assess the extendibility of the equivalent-melanopic function to NIF responses in humans. The KSS response (-Δ KSS) to the different light conditions used on previous studies, preferably including a comparison to a dim light condition, was assessed. Based on the light descriptions of the different studies, the equivalent melanopic lux (m-illuminance) was calculated. The -Δ KSS was plotted against photopic-illuminance and m-illuminance, and fitted to a sigmoidal function already shown to described KSS responses to different light intensities. The root mean-squared error and r(2) were used as criteria to explain the best-describing light unit measurement. Studies that compared only the influence of light under otherwise same conditions and in which participants were not totally sleep deprived were included. Our results show that the effects of light on KSS are better explained by a melanopic unit measurement than by photopic lux. The present analysis allowed for the construction of a melanopic alertness response curve. This curve needs to be validated with appropriate designs. Nonetheless, it may serve as starting point for the development of hypothesis of predictions on the relative changes in KSS under a given condition due to changes in light properties.

EU Water Framework Directive and Stockholm Convention: can we reach the targets for priority substances and persistent organic pollutants?

Science.gov (United States)

Fuerhacker, Maria

2009-08-01

Water is a renewable resource and acceptable quality is important for human health, ecological and economic reasons, but human activity can cause great damage to the natural aquatic environment. Managing the water cycle in a sustainable way is the key to protect natural resources and human health. On a global level, the microbiological contamination of water sources is a major problem in connection with poverty and the United Nations Millennium Development Declaration is an important initiative to handle this problem. In terms of environmental health, persistent organic pollutants (POPs) circulate globally; as they travel long distances, they are found in remote areas far from their original source of application and can cause damage wherever they move to. On a global scale, United Nations Environmental Programme (UNEP) issued the Stockholm Convention to reduce POPs; in the European Union (EU), one intention of the Water Framework Directive (WFD) is to reach the good chemical status of waters; beside these regulations, there are other directives in support of these goals. The aim of this paper is to discuss whether the Stockholm Convention and the WFD allows meeting the targets of protection of human and environmental health, which are established in the different directives and how could we approach the targets. The aims and scopes of different directives are compiled and compared with the actual quality of water, different approaches of standard settings are compared and potential treatment options are discussed. Under the Stockholm Convention on POPs, which came into force in May 2004, governments are required to develop a National Implementation Plan (NIP) setting out how they will address their obligations under the convention and how they will take measures to eliminate or reduce the release of POPs into the environment by the use of best available techniques (BAT) and application of best environmental practices (BEP). On a European level, the WFD has been in

“Recovery” from the diagnosis of autism – and then?

Directory of Open Access Journals (Sweden)

Barnevik Olsson M

2015-04-01

Full Text Available Martina Barnevik Olsson,1,2 Joakim Westerlund,1,3 Sebastian Lundström,1 MaiBritt Giacobini,2,4 Elisabeth Fernell,1,5 Christopher Gillberg1 1Gillberg Neuropsychiatry Centre, Institution of Neuroscience and Physiology, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden; 2PRIMA Child and Adult Psychiatry, Stockholm, Sweden; 3Department of Psychology, Stockholm University, Stockholm, Sweden; 4Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; 5Research and Development Centre, Skaraborg’s Hospital, Skövde, Sweden Background: The aim of this study was to follow up the 17 children, from a total group of 208 children with autism spectrum disorder (ASD, who “recovered from autism”. They had been clinically diagnosed with ASD at or under the age of 4 years. For 2 years thereafter they received intervention based on applied behavior analysis. These 17 children were all of average or borderline intellectual functioning. On the 2-year follow-up assessment, they no longer met criteria for ASD.Methods: At about 10 years of age they were targeted for a new follow-up. Parents were given a semistructured interview regarding the child’s daily functioning, school situation, and need of support, and were interviewed using the Vineland Adaptive Behavior Scales (VABS and the Autism – Tics, Attention-deficit/hyperactivity disorder (AD/HD, and other Comorbidities (A-TAC telephone interview.Results: The vast majority of the children had moderate-to-severe problems with attention/activity regulation, speech and language, behavior, and/or social interaction. A majority of the children had declined in their VABS scores. Most of the 14 children whose parents were A-TAC-interviewed had problems within many behavioral A-TAC domains, and four (29% had symptom levels corresponding to a clinical diagnosis of ASD, AD/HD, or both. Another seven children (50% had pronounced subthreshold indicators of ASD, AD/HD, or both

A quest for antipsychotic drug actions in the brain: personal experiences from 50 years of neuropsychiatric research at Karolinska Institutet.

Science.gov (United States)

Sedvall, Göran

2007-09-10

The exploration of physiological and molecular actions of psychoactive drugs in the brain represents a fundamental approach to the understanding of emerging psychological phenomena. The author gives a personal account of his medical training and research career at Karolinska Institutet over the past 50 years. The paper aims at illustrating how a broad medical education and the integration of basic and clinical neuroscience research is a fruitful ground for the development of new methods and knowledge in this complicated field. Important aspects for an optimal research environment are recruitment of well-educated students, a high intellectual identity of teachers and active researchers, international input and collaboration in addition to good physical resources. In depth exploration of specific signaling pathways as well as an integrative analysis of genes, molecules and systems using multivariate modeling, and bioinformatics, brain mechanisms behind mental phenomena may be understood at a basic level and will ultimately be used for the alleviation and treatment of mental disorders.

Parkinson’s disease permanent care unit: managing the chronic-palliative interface

Directory of Open Access Journals (Sweden)

Lökk J

2011-04-01

Full Text Available Johan LökkDepartment of Neurobiology, Caring Sciences, and Society, Karolinska Institutet; Geriatric Department, Karolinska University Hospital Huddinge, Stockholm, SwedenBackground: Parkinson’s disease (PD eventually leads to severe functional decline and dependence. Specialized care units for PD patients in need of permanent care are lacking.Methods: Patients with severe PD are referred to the PD permanent care unit harboring 30 patients with specialized medical and health care provided by trained staff. Patients need to have intensive medical and care needs, and be no longer able to stay at home or at an ordinary institution. A written and continuously reviewed care plan is made for each patient at admission, with the overriding aim to preserve quality of life and optimize functionality.Results: After five years, the PD permanent care unit has cared for 70 patients (36 men and 34 women with a mean age of 76.6 years and a mean duration of Parkinsonism of 11.8 years. Hoehn and Yahr severity of disease was 3.7, cognition was 25.3 (Mini-Mental State Examination, and the mean daily levodopa dose was 739 mg. The yearly fatality rate was seven, and the mean duration of stay was 26.9 months. Only five patients moved out from the unit.Conclusion: A specially designed and staffed care unit for Parkinsonism patients seems to fill a need for patients and caregivers, as well as for social and health care authorities. This model is sensitive to the changing needs and capacities of patients, ensuring that appropriate services are available in a timely manner. There was a rather short duration of patient stay and remaining life span after admission to the unit. Despite the chronic/palliative state of patients at the PD permanent care unit, there are many therapeutic options, with the overriding objective being to allow the patients to end their days in a professional and comfortable environment.Keywords: Parkinsonism, palliative care, end-stage disease

Death by streaming or vinyl revival? Exploring the spatial dynamics and value-creating strategies of independent record shops in Stockholm

OpenAIRE

Hracs, Brian; Jansson, Johan

2017-01-01

The contemporary retail landscape is in flux and there is a growing perception that shopping at bricks and mortar stores is more expensive and time-consuming than shopping online. For music, illegal downloading and streaming have restructured the retail landscape and put thousands of record shops out of business. Yet, some retailers remain attractive consumption spaces. Drawing on a qualitative case study of independent record shops in Stockholm, this paper considers three value-creating stra...

Measuring subjective sleepiness at work in hospital nurses: validation of a modified delivery format of the Karolinska Sleepiness Scale.

Science.gov (United States)

Geiger Brown, Jeanne; Wieroney, Margaret; Blair, Lori; Zhu, Shijun; Warren, Joan; Scharf, Steven M; Hinds, Pamela S

2014-12-01

Sleepiness during the work shift is common and can be hazardous to workers and, in the case of nurses, to patients under their care. Thus, measuring sleepiness in occupational studies is an important component of workplace health and safety. The Karolinska Sleepiness Scale (KSS) is usually used as a momentary assessment of a respondent's state of sleepiness; however, end-of-shift measurement is sometimes preferred based on the study setting. We assessed the predictive validity of the KSS as an end-of-shift recall measurement, asking for "average" sleepiness over the shift and "highest" level of sleepiness during the shift. Hospital registered nurses (N=40) working 12-h shifts completed an end-of-shift diary over 4 weeks that included the National Aeronautical and Space Administration Task Load Index (NASA-TLX) work intensity items and the KSS (498 shifts over 4 weeks). Vigilant attention was assessed by measuring reaction time, lapses, and anticipations using a 10-min performance vigilance task (PVT) at the end of the shift. The Horne-Ostberg Questionnaire, Epworth Sleepiness Scale, General Sleep Disturbance Scale, and Cleveland Sleep Habits Questionnaire were also collected at baseline to assess factors that could be associated with higher sleepiness. We hypothesized that higher KSS scores would correlate with vigilant attention parameters reflective of sleepiness (slower reaction times and more lapses and anticipations on a performance vigilance task) and also with those factors known to produce higher sleepiness. These factors included the following: (1) working night shifts, especially for those with "morningness" trait; (2) working sequential night shifts; (3) having low physical and mental work demands and low time pressure; (4) having concomitant organic sleep disorders; and (5) having greater "trait" sleepiness (Epworth Sleepiness Scale). Linear mixed models and generalized linear mixed models were used to test associations that could assess the predictive

Aligning the systems of environmental accounting: From EU to Stockholm and vice versa

Energy Technology Data Exchange (ETDEWEB)

Burstroem, F.; Frostell, B. [Royal Inst. of Technology, Stockholm (Sweden). Dept. of Environmental Technology and Work Science

2001-07-01

During the last decade, authorities in local and regional communities, nations and international governance organisations, like the European Union (EU), have developed several systems for environmental accounting. An important issue in this development is the collection and collation of data. Except for the question of what data to collect, there is also a question of how to collect data. Focusing in particular on developments of physical environmental accounting systems in Sweden, a member nation of the EU, and drawing from experiences from work with materials accounting in the City of Stockholm, this paper discusses the need to align environmental accounting systems of different societal levels. It is argued that the systems of collecting 'environmental' data have to be better aligned with the objectives and strategies of environmental management and policy making, taking into account all aspects of utilisation of the basic data to be collected. If not, the result will be a conservation of the fragmented point solutions of environmental accounting systems we face today, resulting in inconsistency of data, duplication of data collection and processing efforts, and inflexibility to deal with changes. From this, it is also argued that the collection of data for physical environmental accounting (i.e. data on flows and stocks of materials and substances in society and the environment), would preferably be performed by a local/regional authority, but co-ordinated by national authorities and a national statistical office, under supervision of international authorities and statistical offices. Finally, the paper presents a structural framework for regional materials accounting, which combines a product-oriented strand with a substance-oriented strand of materials accounting, and allows for accounting and analysis on different levels of aggregation. This framework, which has been developed in co-operation with the City of Stockholm, should mainly be considered

Regional development via high-speed rail : A study of the Stockholm-Mälaren region and possibilities for Melbourne-regional Victoria

OpenAIRE

Bayley, Michael

2012-01-01

The purpose of this thesis is to examine, based on a study of the regional high-speed corridors in the Stockholm-Mälaren Region, the possibilities for regional high-speed rail in Melbourne-regional Victoria (Australia) to improve accessibility, and achieve regional development and balanced growth between the capital and its surrounding regions. It deals with the concept of 'regional' high-speed rail, a variant of classic high-speed rail that serves centres along regional corridors stemming fr...

Discussing compliance. Summary report from discussions with Robert Bernero and Chris Whipple regarding compliance with the Swedish HLW Regulations from meetings in Stockholm May 3 and 4, 1999

Energy Technology Data Exchange (ETDEWEB)

Jensen, Mikael

1999-06-01

Summary report from discussions with Robert Bernero and Chris Whipple regarding compliance with the Swedish HLW Regulations from meetings in Stockholm. The report also contains bibliographical information and preliminary observations made by Robert Bernero and Chris Whipple.

Discussing compliance. Summary report from discussions with Robert Bernero and Chris Whipple regarding compliance with the Swedish HLW Regulations from meetings in Stockholm May 3 and 4, 1999

International Nuclear Information System (INIS)

Jensen, Mikael

1999-06-01

Summary report from discussions with Robert Bernero and Chris Whipple regarding compliance with the Swedish HLW Regulations from meetings in Stockholm. The report also contains bibliographical information and preliminary observations made by Robert Bernero and Chris Whipple

Early diagnosis of autism and impact on prognosis: a narrative review

Directory of Open Access Journals (Sweden)

Fernell E

2013-02-01

Full Text Available Elisabeth Fernell,1 Mats Anders Eriksson,1,2 Christopher Gillberg11Gillberg Neuropsychiatry Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; 2Department of Women's and Children's Health, Karolinska Institute, Stockholm, SwedenAbstract: Autism spectrum disorders involve a set of clinical phenotypes that mirror an early onset of neurodevelopmental deviations, with core symptoms that can probably be related to a deficiency in the social instinct. Underlying the cognitive impairments there are physiological brain problems, caused by a large number of medical factors. This narrative review of systematic reviews and meta-analyses from the last 5 years (2008–2012 presents aspects from many areas in autism spectrum disorder research, with a particular focus on early intervention and the subsequent impact on prognosis. Other major areas discussed are epidemiology, early symptoms and screening, early diagnosis, neuropsychology, medical factors, and the existence of comorbidities. There is limited evidence that any of the broadband “early intervention” programs are effective in changing the natural long-term outcome for many individuals with an early diagnosis of autism. However, there is some evidence that Early Intensive Behavioral Intervention (EIBI is an effective treatment for some children with ASD. Nevertheless, there is emerging consensus that early diagnosis and information are needed in order that an autism-friendly environment be “created” around affected individuals.Keywords: autism spectrum disorder, epidemiology, screening, etiology, intervention, outcome

The impact on social capital of mobility disability and weight status: the Stockholm Public Health Cohort.

Science.gov (United States)

Norrbäck, Mattias; de Munter, Jeroen; Tynelius, Per; Ahlström, Gerd; Rasmussen, Finn

2015-04-01

People with mobility disability are more often overweight or obese and have lower social capital than people without mobility disability. It is unclear whether having a combination of mobility disability and overweight or obesity furthers negative development of social capital over time. To explore whether there were differences in social capital between normal-weight, overweight and obese people with or without mobility disability over a period of 8 years. We included 14,481 individuals (18-64 at baseline) from the Stockholm Public Health Cohort that started in 2002. Mobility disability, weight status, and social capital (structural: social activities, voting; cognitive: trust in authorities, and trust in people) were identified from self-reports. Risk ratios with 95% confidence intervals were estimated in multivariate longitudinal regression analyses. We found no significant differences in social activities and voting between the groups over time. However, when compared with the reference group, the groups with mobility disability had less trust in authorities and public institutions over time. Notably, obese people with mobility disability showed the largest decrease in trust in the police (RR = 2.29; 1.50-3.50), the parliament (RR = 2.00; 1.31-3.05), and local politicians (RR = 2.52; 1.61-3.94). People with mobility disability experience lower cognitive social capital over time than people without mobility disability. Being burdened by both mobility disability and obesity may be worse in terms of social capital than having just one of the conditions, especially regarding cognitive social capital. This finding is of public health importance, since social capital is related to health. Copyright © 2015 Elsevier Inc. All rights reserved.

Incidence, aetiology and injury characteristics of traumatic spinal cord injury in Stockholm, Sweden: A prospective, population-based update.

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Joseph, Conran; Andersson, Nina; Bjelak, Sapko; Giesecke, Kajsa; Hultling, Claes; Nilsson Wikmar, Lena; Phillips, Julie; Seiger, Åke; Stenimahitis, Vasilios; Trok, Katarzyna; Åkesson, Elisabet; Wahman, Kerstin

2017-05-16

To update the incidence rate, aetiology and injury characteristics of acutely-injured adults with traumatic spinal cord injury in Stockholm, Sweden, using international standards of reporting. Prospective, (regional) population-based observation. Forty-nine consecutively enrolled individuals. A surveillance system of newly-injured adults with traumatic spinal cord injury was implemented for an 18-month period. The International Spinal Cord Injury Core Data Set was used to collect data on those who survived the first 7 days post-injury. After an 18-month period, 49 incident cases were registered, of whom 45 were included in this study. The crude incidence rate was 19.0 per million, consisting mainly of men (60%), and the mean age of the cohort was 55 years (median 58). Causes of injury were almost exclusively limited to falls and transport-related events, accounting for 58% and 40% of cases, respectively. The incidence has remained stable when compared with the previous study; however, significant differences exist for injury aetiology (p = 0.004) and impairment level (p = 0.01) in that more fall- and transport-related spinal cord injury occurred, and a larger proportion of persons was left with resultant tetraplegia, in the current study, compared with more sport-related injuries and those left with paraplegia in the previous study. The incidence rate appeared to remain stable in Stockholm, Sweden. However, significant changes in injury aetiology and impairment-level post injury were found, compared with the previous study. There remains a need for developing fall-related prevention strategies in rehabilitation settings as well as in population-based programmes.

Annual Report 1979. Research Institute of physics Stockholm

International Nuclear Information System (INIS)

1979-01-01

Following a list of the research personnel, brief reports are presented on research projects in the fields of surface, atomic and molecular physics, atomic and molecular theory, nuclear physics, nuclear theory, exotic atoms and instrumentation and methods. There follow lists of seminars held, publications, theses and the main topics of a workshop on very stable nuclear systems held at Kornoe, 26-28 Aug 1979. (JIW)

Radiofrequency radiation at Stockholm Central Railway Station in Sweden and some medical aspects on public exposure to RF fields

OpenAIRE

Hardell, Lennart; Koppel, Tarmo; Carlberg, Michael; Ahonen, Mikko; Hedendahl, Lena

2016-01-01

The Stockholm Central Railway Station in Sweden was investigated for public radiofrequency (RF) radiation exposure. The exposimeter EME Spy 200 was used to collect the RF exposure data across the railway station. The exposimeter covers 20 different radiofrequency bands from 88 to 5,850 MHz. In total 1,669 data points were recorded. The median value for total exposure was 921 ?W/m2 (or 0.092 ?W/cm2; 1 ?W/m2=0.0001 ?W/cm2) with some outliers over 95,544 ?W/m2 (6 V/m, upper detection limit). The...

Multi-organ expression profiling uncovers a gene module in coronary artery disease involving transendothelial migration of leukocytes and LIM domain binding 2: The Stockholm Atherosclerosis Gene Expression (STAGE) study

KAUST Repository

Hä gg, Sara; Skogsberg, Josefin; Lundströ m, Jesper; Noori, Peri; Nilsson, Roland; Zhong, Hua; Maleki, Shohreh; Shang, Ming-Mei; Brinne, Bjö rn; Bradshaw, Maria; Bajic, Vladimir B.; Samnegå rd, Ann; Silveira, Angela; Kaplan, Lee M.; Gigante, Bruna; Leander, Karin; de Faire, Ulf; Rosfors, Stefan; Lockowandt, Ulf; Liska, Jan; Konrad, Peter; Takolander, Rabbe; Franco-Cereceda, Anders; Schadt, Eric E.; Ivert, Torbjö rn; Hamsten, Anders; Tegné r, Jesper; Bjö rkegren, Johan

2009-01-01

of coronary artery disease (CAD). The primary aim of the Stockholm Atherosclerosis Gene Expression (STAGE) study was to determine whether there are functionally associated genes (rather than individual genes) important for CAD development. To this end, two

Karolinska Scales of Personality, cognition and psychotic symptoms in patients with schizophrenia and healthy controls.

Science.gov (United States)

Nilsson, Björn Mikael; Holm, Gunnar; Ekselius, Lisa

2016-01-01

Studies on both personality dimensions and cognition in schizophrenia are scarce. The objective of the present study was to examine personality traits and the relation to cognitive function and psychotic symptoms in a sample of patients with schizophrenia and healthy controls. In total 23 patients with schizophrenia and 14 controls were assessed with the Karolinska Scales of Personality (KSP). A broad cognitive test programme was used, including the Wechsler Adult Intelligence Scales, the Finger-Tapping Test, the Trail Making Test, the Verbal Fluency Test, the Benton Visual Retention Test, the Wisconsin Card Sorting Test and Rey Auditory Verbal Learning Test . Compared with controls, the patients exhibited prominent elevations on KSP scales measuring anxiety proneness and neuroticism (P = 0.000005-0.0001), on the Detachment scale (P < 0.00009) and lower value on the Socialization scale (P < 0.0002). The patients also scored higher on the Inhibition of Aggression, Suspicion, Guilt and Irritability scales (P = 0.002-0.03) while the remaining five scales did not differ between patients and controls. KSP anxiety-related scales correlated with the Positive and Negative Symptoms Scale (PANSS) general psychopathology subscale. Cognitive test results were uniformly lower in the patient group and correlated with PANSS negative symptoms subscale. There was no association between KSP scale scores and PANSS positive or negative symptoms. The patients revealed a highly discriminative KSP test profile with elevated scores in neuroticism- and psychoticism-related scales as compared to controls. Results support previous findings utilizing other personality inventories in patients with schizophrenia. Cognitive test performance correlated inversely with negative symptoms.

The Nordic Countries Meeting on the Zebrafish as a Model for Development and Disease 2012

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Zetterberg, Henrik

2013-01-01

Abstract The first Nordic Countries Meeting on the Zebrafish as a Model for Development and Disease took place at Karolinska Institutet in Stockholm, November 21–23, 2012. The meeting gathered 130 scientists, students, and company representatives from Iceland, Finland, Norway, Denmark, and Sweden, as well as invited guests and keynote speakers from England, Scotland, Germany, Poland, The Netherlands, Singapore, Japan, and the United States. Presentations covered a wide range of topics, including developmental biology, genetics, evolutionary biology, toxicology, behavioral studies, and disease mechanisms. The need for formal guidance and training in zebrafish housing, husbandry, and health monitoring was recognized, and the meeting expressed its support for the joint working group of the FELASA/COST action BM0804 EuFishBioMed. The decision was made to turn the Nordic meeting into an annual event and create a Nordic network of zebrafish researchers. PMID:23590403

Promoting international collaboration and creativity in doctoral students.

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Groen, Christopher M; McGrath, Cormac; Campbell, Katherine A; Götherström, Cecilia; Windebank, Anthony J; Landázuri, Natalia

2017-06-22

Staff from the Mayo Clinic in the US and the Karolinska Institute in Sweden describe a joint transatlantic course intended to broaden the horizons of the next generation of researchers in the field of regenerative medicine.

Origins of individual differences in anxiety proneness: a twin/adoption study of the anxiety-related scales from the Karolinska Scales of Personality (KSP).

Science.gov (United States)

Gustavsson, J P; Pedersen, N L; Asberg, M; Schalling, D

1996-06-01

The genetic and environmental origins of individual differences in scores on the anxiety-proneness scales from the Karolinska Scales of Personality were explored using a twin/adoption study design in a sample consisting of 15 monozygotic twin pairs reared apart, and 26 monozygotic and 29 dizygotic twin pairs reared together. The results showed that genetic factors accounted for individual differences in scores on the psychasthenia and somatic anxiety scales. The genetic determinants were not specific to each scale, but were common to both scales. Shared-rearing environmental determinants were important for individual differences in lack of assertiveness and psychic anxiety, and were common to both scales. Individual differences in muscular tension were found to be attributable to the effects of correlated environments. The most important factor explaining individual differences for all scales was the non-shared environment component. The evidence for an aetiologically heterogeneous anxiety-proneness construct emphasizes the appropriateness of a multi-dimensional approach to anxiety proneness.

Do tax incentives affect households' adoption of ‘green’ cars? A panel study of the Stockholm congestion tax

International Nuclear Information System (INIS)

Mannberg, Andrea; Jansson, Johan; Pettersson, Thomas; Brännlund, Runar; Lindgren, Urban

2014-01-01

Policymakers have made several attempts to introduce local and national policies to reduce CO 2 emissions and stimulate the consumer adoption of alternative fuel vehicles (ethanol/E85 cars). The purpose of this paper is to analyze how a local policy measure impacts the composition of the car fleet over time. More specifically, we take advantage of the natural experiment setting caused by the introduction of the Stockholm congestion tax (2006) to analyze how the tax affected purchases of ethanol cars that were exempted from the tax. To estimate effects, we employ a Difference-in-differences methodology. By using a comprehensive database of the car fleet and car owners, sociodemographic and geographic factors are analyzed, which is unique in the existing literature. Our results suggest that the congestion tax had a significant impact on ethanol car purchases although the effect fades away over time. Furthermore, there is a positive relationship between the level of education and ethanol car purchases. Previous adoption of an ethanol car is found to be the strongest predictor of ethanol car purchases. Finally, data indicate that Stockholmers substantially increased purchases of ethanol cars half a year before the introduction of the congestion tax, which we refer to as an anticipation effect. - Highlights: • Uses a database of car owners to analyze impacts of a congestion tax on car fleet. • Results show that the tax had a significant effect on ethanol car purchases. • Prior ownership of ethanol car and education correlates with ethanol car purchases

Joint physical custody, turning to parents for emotional support, and subjective health: A study of adolescents in Stockholm, Sweden.

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Låftman, Sara Brolin; Bergström, Malin; Modin, Bitte; Östberg, Viveca

2014-07-01

Among children with separated parents, the arrangement of joint physical custody, i.e. children living equally much in both parents' homes, has increased substantially during the last decades in Sweden. To date, empirical research on the living conditions of this group is limited. This study analyses family type differences in turning to parents for emotional support and in subjective health among adolescents. The focus of the study is adolescents in joint physical custody, who are compared with those living with two original parents in the same household; those living (only) in a single-parent household; and those living (only) in a reconstituted family. The data come from the Stockholm School Survey of 2004, a total population survey of students in grade 9 (15-16 years) in Stockholm (n=8,840). Ordinary least squares (OLS) regressions were conducted. Turning to both parents about problems is most commonly reported by adolescents in intact families, followed by those in joint physical custody. Adolescents in non-traditional family types report worse subjective health than adolescents in intact families, but the difference is smaller for those in joint physical custody than for those living with a single parent. The slightly poorer health of adolescents in joint physical custody than those in intact families is not explained by their lower use of parents as a source of emotional support. The study suggests that joint physical custody is associated with a higher inclination to use parents as a source of emotional support and better subjective health than other post-divorce family types. © 2014 the Nordic Societies of Public Health.

Experiences and attitudes about physical activity and exercise in patients with chronic pain: a qualitative interview study

Directory of Open Access Journals (Sweden)

Karlsson L

2018-01-01

Full Text Available Linn Karlsson,1 Björn Gerdle,1 Esa-Pekka Takala,2 Gerhard Andersson,3,4 Britt Larsson1 1Pain and Rehabilitation Centre, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden; 2Work-related Diseases, Finnish Institute of Occupational Health, Helsinki, Finland; 3Department of Behavioural Sciences and Learning, Swedish Institute for Disability Research, Linköping University, Linköping, Sweden; 4Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institute, Stockholm, Sweden Purpose: The purpose of this study was to describe how patients with chronic pain experience physical activity and exercise (PA&E.Method: This qualitative interview study included 16 women and two men suffering from chronic pain and referred to a multimodal pain rehabilitation program. Semi-structured interviews were conducted and qualitative content analysis was used to analyze the interviews.Results: One main theme emerged: “To overcome obstacles and to seize opportunities to be physically active despite chronic pain.” This main theme was abstracted from five themes: “Valuing a life with physical activity,” “Physical activity and exercise – before and after pain,” “A struggle – difficulties and challenges,” “The enabling of physical activity,” and “In need of continuous and active support.” Conclusion: Although these participants valued PA&E, they seldom achieved desirable levels, and performance of PA&E was undermined by difficulties and failure. The discrepancy between the intention to perform physical activity and the physical activity accomplished could be related to motivation, self-efficacy, and action control. The participants desired high-quality interaction with healthcare providers. The findings can be applied to chronic pain rehabilitation that uses PA&E as treatment. Keywords: chronic pain, experiences, physical activity, rehabilitation, qualitative content analysis

Who takes paternity leave? A cohort study on prior social and health characteristics among fathers in Stockholm.

Science.gov (United States)

Månsdotter, Anna; Fredlund, Peeter; Hallqvist, Johan; Magnusson, Cecilia

2010-09-01

Progress towards gender equality involves changes in the traditional parental division - female caring and male breadwinning. One aspect is increased parental leave for fathers, which may benefit the health of mothers, children, and fathers themselves. We examined how social and health characteristics (2002) were associated with paternity leave in excess of the 'father quota' of 60 days (2003-2006) in the Stockholm Public Health Cohort. Generally, fathers with stable social position, fit lifestyles, and good health had increased chances of paternity leave uptake. Our findings may contribute to identifying target groups for parental leave strategies among fathers; they indicate also that research on gender equality and public health must carefully address the problems of confounding and health-related selection.

A new multiple regression model to identify multi-family houses with a high prevalence of sick building symptoms "SBS", within the healthy sustainable house study in Stockholm (3H).

Science.gov (United States)

Engvall, Karin; Hult, M; Corner, R; Lampa, E; Norbäck, D; Emenius, G

2010-01-01

The aim was to develop a new model to identify residential buildings with higher frequencies of "SBS" than expected, "risk buildings". In 2005, 481 multi-family buildings with 10,506 dwellings in Stockholm were studied by a new stratified random sampling. A standardised self-administered questionnaire was used to assess "SBS", atopy and personal factors. The response rate was 73%. Statistical analysis was performed by multiple logistic regressions. Dwellers owning their building reported less "SBS" than those renting. There was a strong relationship between socio-economic factors and ownership. The regression model, ended up with high explanatory values for age, gender, atopy and ownership. Applying our model, 9% of all residential buildings in Stockholm were classified as "risk buildings" with the highest proportion in houses built 1961-1975 (26%) and lowest in houses built 1985-1990 (4%). To identify "risk buildings", it is necessary to adjust for ownership and population characteristics.

Sensitization of children in the Stockholm area to house dust mites.

Science.gov (United States)

Nordvall, S L; Eriksson, M; Rylander, E; Schwartz, B

1988-09-01

Atopic sensitization of children in the Stockholm area to house dust mites (HDM) was investigated in a case-control study. Sixty children with and 60 without positive skin prick tests for HDM were matched for age and sex. HDM-sensitized children had previously more often lived in other areas known to be mite infested than the control children. Sensitization to mites was related to dampness in the homes, but no significant relationship was found to the type of residence, frequent visits to a summer house in the archipelago or parental smoking. Dust samples from mattresses of the children with the strongest positive reactions to mites in skin prick tests and the respective controls were subjected to an enzyme immunoassay, to measure the content of the major allergens of the Dermatophagoides (D.) species D. pterinyssinus, D. farinae and D. microceras. Mattress dust samples from the beds of HDM-sensitized children contained significantly higher HDM antigen concentrations than those from the beds of controls. Private houses contained significantly more HDM antigens than flats and 10 of 11 homes in which a dampness problem was recognized contained mite antigens. It is postulated that mite infestation is increasing in the area, energy-saving measures creating improved conditions for HDM survival.

Combining the Suicide Intent Scale and the Karolinska Interpersonal Violence Scale in suicide risk assessments.

Science.gov (United States)

Stefansson, J; Nordström, P; Runeson, B; Åsberg, M; Jokinen, J

2015-09-23

High suicide intent, childhood trauma, and violent behavior are risk factors for suicide in suicide attempters. The aim of this study was to investigate whether the combined assessment of suicide intent and interpersonal violence would provide a better prediction of suicide risk than an assessment of only suicide intent or interpersonal violence. This is a cohort study involving 81 suicide attempters included in the study between 1993 and 1998. Patients were assessed with both the Suicide Intent Scale (SIS) and the Karolinska Interpersonal Violence Scale (KIVS). Through the unique personal identification number in Sweden, patients were linked to the Cause of Death Register maintained by the Swedish National Board of Health and Welfare. Suicides were ascertained from the death certificates. Seven of 14 patients who had died before April 2013 had committed suicide. The positive predictive value for the Suicide Intent Scale alone was 16.7 %, with a specificity of 52 % and an area under the curve of 0.74. A combined assessment with the KIVS gave higher specificity (63 %) and a positive predictive value of 18.8 % with an AUC of 0.83. Combined use of SIS and KIVS expressed interpersonal violence as an adult subscale gave a sensitivity of 83.3 %, a specificity of 80.3 %, and a positive predictive value of 26 % with an AUC of 0.85. The correlation between KIVS and SIS scores was not significant. Using both the the SIS and the KIVS combined may be better for predicting completed suicide than using them separately. The nonsignificant correlation between the scales indicates that they measure different components of suicide risk.

Adalimumab (Humira) restores clinical response in patients with secondary loss of efficacy from infliximab (Remicade) or etanercept (Enbrel): results from the STURE registry at Karolinska University Hospital.

Science.gov (United States)

Wick, M C; Ernestam, S; Lindblad, S; Bratt, J; Klareskog, L; van Vollenhoven, R F

2005-01-01

To determine whether the tumour necrosis factor-alpha (TNF-alpha) antagonist adalimumab (Humira) can be efficacious after secondary loss of efficacy (i.e. loss of clinical response in patients who had initially demonstrated clinical response) to infliximab (Remicade) or etanercept (Enbrel). We studied 36 patients from the Stockholm TNF-alpha follow-up registry (STURE) who received adalimumab after secondary loss of efficacy to infliximab (group A, n = 27) or etanercept (group B, n = 9), and 26 patients who were started on adalimumab as the first TNF-alpha antagonist (group C). In group A, the baseline disease activity score 28 (DAS28) at infliximab institution was 5.5+/-0.2. During infliximab treatment, the mean best DAS28 was 3.7+/-0.2 (p<0.001), but increased to 5.2+/-0.3 when infliximab was stopped. After 3 months on adalimumab, the mean DAS28 decreased to 4.5+/-0.3 (p<0.003), and then to 4.2+/-0.2 at 6 months (p<0.001). In group B, the baseline DAS28 at etanercept institution was 6.6+/-0.5. During etanercept treatment, the mean best DAS28 was 4.6+/-0.5 (p<0.01), but increased to 5.7+/-0.4 by the time etanercept was stopped. After 3 months on adalimumab, the mean DAS28 decreased to 4.8+/-0.3 (p<0.005), and to 4.1+/-0.2 at 6 months (p<0.001). In group C, the mean baseline DAS28 was 5.6+/-0.3. After 6 months of adalimumab therapy, the DAS28 decreased to 3.5+/-0.4 (p<0.001). ACR20 responses with adalimumab in groups A, B, and C were similar (70-78%). For patients with secondary loss of efficacy from infliximab or etanercept, switching to adalimumab can restore a good clinical response.

Risk of self-reported Chlamydia trachomatis infection by social and lifestyle factors: a study based on survey data from young adults in Stockholm, Sweden.

Science.gov (United States)

Deogan, Charlotte; Cnattingius, Sven; Månsdotter, Anna

2012-12-01

To analyse the associations between demographic, socio-economic and lifestyle factors, and the risk of self-reported chlamydial infection among young adults (20-29 years old) in Stockholm, Sweden. This study was based on the Stockholm Public Health Survey of 2006 (N = 4278). Demographic factors (gender, age, and country of birth), socio-economic factors (individual and parental educational levels, individual income level, and employment status), and lifestyle factors (body mass index, mental health, alcohol consumption, and partnership status) were taken into account. Possible associations were analysed by logistic regression. The risk of self-reported chlamydial infection decreases with age, is higher among individuals both who personally, and whose parents, were educated to high school level compared to university level education, and is higher among those employed, unemployed or on sick-leave/pre-retired compared to students. The risk of chlamydial infection is also higher among subjects who report greater alcohol consumption, and those who live without a partner. After considering demographic, socio-economic and lifestyle factors, the associations with age, educational level, employment status and alcohol consumption are strong and statistically significant. Indicators of risk-taking behaviours, especially in settings with generally little educational ambition or options, should be incorporated in the design of STI prevention strategies.

Review of the LIBER “Think Tank on the future value of the book as artefact and the future value of digital documentary heritage”, National Library of Sweden, Stockholm, Sweden, 24-25 May 2007

Directory of Open Access Journals (Sweden)

Andrea Langendoen

2007-12-01

Full Text Available What is the future of the book, or maybe rather, does the book have a future at all? These are questions that are raised again and again within different disciplines in the digital age, from e-strategists to historical bibliographers. During a two-day Think Tank, held at the Swedish National Library at Stockholm on May 24-25, authors, critics, scholars, representatives of libraries, archives and other heritage institutions and knowledge organizations tried to find answers to these and other related questions, such as: do the concepts of ‘value’ and ‘authenticity’, which are based on physical objects still have any meaning? Does digitisation decrease or increase the value of the book as an artefact? Will the rapid growth of digitised and born-digital publications lead to a new digital cultural heritage? Indeed, has the critical mass of ‘born digital’ and digitised material already created a new digital cultural documentary heritage?

International institute of tropical agriculture plantain and banana ...

African Journals Online (AJOL)

STORAGESEVER

2008-07-04

Jul 4, 2008 ... the Training and Visit (T and V) management system is to trigger and ... an essential feature of sustainable agricultural innovation ... plantain hybrids growing farmers, the pilot farmers (direct project ..... Foundation For Science (IFS) Stockholm, Sweden. ... Cv.AAB) production in compound gardens in.

Markus Maeurer on the LifeGene project.

Science.gov (United States)

Maeurer, Markus

2010-09-01

This year will see the full-scale roll-out of the LifeGene study. Coordinated by the Karolinska Institutet (Stockholm, Sweden), the project looks set to be one of the largest health studies performed in the world, aiming to enroll 500,000 Swedes in order to determine the relationship between disease and environmental, lifestyle and hereditary factors. International experts from a broad spectrum of scientific fields will collaborate on this project, including Mark Maeurer, Chair of the infections working group in LifeGene (www.lifegene.se). Maeurer leads the additional study on influenza-like illnesses, which is currently being run within the LifeGene project. Maeurer studied medicine in Germany, Switzerland and the USA. He is board-certified in medical microbiology, has served as Assistant Professor of Surgery at the University of Pittsburgh Medical School (PA, USA) in the Department of Surgical Oncology and Immunotherapy, as Professor of Medical Microbiology at the University of Mainz, Germany, and is now Professor of Clinical Immunology at the Microbiology and Tumor Cell Biology Center at the Karolinska Institutet. Maeurer has conducted experiments with nonhuman primate models to study TB vaccine take, with the aim to profile markers of immune protection. His general interests are in the field of immune reconstitution and memory immune responses, with a particular focus on gauging protective T-cell responses and antibody immune signatures using high-content peptide microarrays. He has published more than 100 original articles, ten book chapters and serves as a reviewer for a number of international scientific journals.

A preliminary approach to characterizing variability and uncertainty in the mammalian PCDD/F and PCB TEFs

Energy Technology Data Exchange (ETDEWEB)

Haws, L. [Exponent, Austin, TX (United States); Harris, M.; Santamaria, A. [Exponent, Houston, TX (United States); Su, S. [Exponent, New York, NY (United States); Walker, N. [National Institute of Environmental Health Sciences, Research Triangle Park, NC (United States); Birnbaum, L.; DeVito, M. [U.S. Environmental Protection Agency, Research Triangle Park, NC (United States); Farland, W. [U.S. Environmental Protection Agency, Washington, DC (United States); Connor, K. [Exponent, Natick, MA (United States); Finley, B. [Exponent, Santa Rosa, CA (United States)

2004-09-15

The current toxic equivalency factors (TEFs) for PCDD/Fs and ''dioxin-like'' PCBs represent consensus-based values that were recommended by an international panel of experts convened by the World Health Organization (WHO) in June of 1997. As a part of the development of the mammalian TEFs, the WHO expert panel considered an extensive body of in vivo and in vitro studies compiled into a database of relative potency (REP) values by scientists at the Karolinska Institute in Stockholm Sweden (hereafter referred to as the Karolinska database). The final TEFs recommended by the WHO expert panel were determined based on scientific judgment and represent order-of magnitude estimates of potency for each of the congeners relative to 2,3,7,8-tetrachlorodibenzo-pdioxin (TCDD). As has been indicated by a number of investigators, the REP values for many congeners are derived from a highly heterogeneous data set, and for most TEFs, the range of underlying REP values often spans several orders of magnitude. However, the degree to which the current ''point estimate'' TEFs introduce variability and uncertainty into the health risk assessment process cannot be characterized in a quantitative fashion. Such characterizations may be important in settings where numerous PCDD/F and PCB congeners contribute to potential health risk. We believe that the use of REP distributions, as a supplement to or in place of ''point estimate'' TEFs, would facilitate such characterizations. Specifically, use of a range of REP values, perhaps with a clearly identified ''central tendency'' (e.g., 50{sup th} percentile) and/or ''upper bound'' (e.g., 90{sup th} or 95{sup th} percentile), would permit more informed discussions regarding the degree to which the TEFs contribute to variability and uncertainty in health risk estimates. This is important given the widespread use of the TEFs by numerous governmental

Municipal policies and plans of action aiming to promote physical activity and healthy eating habits among schoolchildren in Stockholm, Sweden: a cross-sectional study.

Science.gov (United States)

Guldbrandsson, Karin; Wennerstad, Karin Modig; Rasmussen, Finn

2009-08-03

Promoting physical activity and healthy eating habits by structural measures that reach most children in a society is presumably the most sustainable way of preventing development of overweight and obesity in childhood. The main purpose of the present study was to analyse whether policies and plans of action at the central level in municipalities increased the number of measures that aim to promote physical activity and healthy eating habits among schoolchildren aged six to 16. Another purpose was to analyse whether demographic and socio-economic characteristics were associated with the level of such measures. Questionnaires were used to collect data from 25 municipalities and 18 town districts in Stockholm County, Sweden. The questions were developed to capture municipal structural work and factors facilitating physical activity and the development of healthy eating habits for children. Local policy documents and plans of action were gathered. Information regarding municipal demographic and socio-economic characteristics was collected from public statistics. Policy documents and plans of action in municipalities and town districts did not seem to influence the number of measures aiming to promote physical activity and healthy eating habits among schoolchildren in Stockholm County. Municipal demographic and socio-economic characteristics were, however, shown to influence the number of measures. In town districts with a high total population size, and in municipalities and town districts with a high proportion of adults with more than 12 years of education, a higher level of health-promoting measures was found. In municipalities with a high annual population growth, the number of measures was lower than in municipalities with a lower annual population growth. Another key finding was the lack of agreement between what was reported in the questionnaires regarding existence and contents of local policies and plans of action and what was actually found when these

Using the Karolinska Sleep Questionnaire to identify obstructive sleep apnea syndrome in a sleep clinic population.

Science.gov (United States)

Westerlund, Anna; Brandt, Lena; Harlid, Richard; Åkerstedt, Torbjörn; Lagerros, Ylva Trolle

2014-10-01

In Scandinavia, portable monitoring has virtually replaced standard polysomnography for diagnosis of obstructive sleep apnea syndrome (OSAS). Because waiting times for specialized OSAS care remain long, an accurate screening tool to exclude low-risk patients from diagnostic testing would be valuable. To examine the diagnostic accuracy of the Karolinska Sleep Questionnaire (KSQ) for OSAS. Consecutive patients, 30–66 years old, attending a large sleep clinic in Sweden for OSAS evaluation completed the KSQ and underwent in-home portable monitoring and medical history evaluation. OSAS was defined as apnea-hypopnea index ≥5 with symptoms of disease. We calculated sensitivity and specificity of apnea/snoring and sleepiness indices of the KSQ. Retrospectively, we combined six KSQ items (snoring, breathing cessations, disturbed sleep, etc.) and four clinical variables (age, sex, body mass index, smoking status) predictive of OSAS into a new instrument, which we also evaluated. Instrument score ranged between 0 and 21; a higher score indicated more severe symptoms. Of 103 patients, 62 were diagnosed with OSAS. Sensitivity and specificity of the indices were 0.56 and 0.68 (apnea/snoring), and 0.37 and 0.71 (sleepiness). The new instrument performed optimally at a score of 9. Sensitivity was 0.76 (95% confidence interval 0.63–0.86) and specificity 0.88 (0.74–0.96). Between 19.4% and 50.5% of patients were unaware of having apnea/snoring symptoms. Diagnostic accuracy of the apnea/snoring and sleepiness indices for OSAS was poor but could be improved by combining clinical and KSQ items. The usefulness of the apnea/snoring index and the combined instrument was questionable because of extensive symptom unawareness.

Individual exposure to NO2 in relation to spatial and temporal exposure indices in Stockholm, Sweden: the INDEX study.

Directory of Open Access Journals (Sweden)

Tom Bellander

Full Text Available Epidemiology studies of health effects from air pollution, as well as impact assessments, typically rely on ambient monitoring data or modelled residential levels. The relationship between these and personal exposure is not clear. To investigate personal exposure to NO(2 and its relationship with other exposure metrics and time-activity patterns in a randomly selected sample of healthy working adults (20-59 years living and working in Stockholm. Personal exposure to NO(2 was measured with diffusive samplers in sample of 247 individuals. The 7-day average personal exposure was 14.3 µg/m(3 and 12.5 µg/m(3 for the study population and the inhabitants of Stockholm County, respectively. The personal exposure was significantly lower than the urban background level (20.3 µg/m(3. In the univariate analyses the most influential determinants of individual exposure were long-term high-resolution dispersion-modelled levels of NO(2 outdoors at home and work, and concurrent NO(2 levels measured at a rural location, difference between those measured at an urban background and rural location and difference between those measured in busy street and at an urban background location, explaining 20, 16, 1, 2 and 4% (R(2 of the 7-day personal NO(2 variation, respectively. A regression model including these variables explained 38% of the variation in personal NO(2 exposure. We found a small improvement by adding time-activity variables to the latter model (R(2 = 0.44. The results adds credibility primarily to long-term epidemiology studies that utilise long-term indices of NO(2 exposure at home or work, but also indicates that such studies may still suffer from exposure misclassification and dilution of any true effects. In contrast, urban background levels of NO(2 are poorly related to individual exposure.

Annual report 1977. Research institute of physics, Stockholm Sweden

International Nuclear Information System (INIS)

Nilsson, A.

1978-01-01

A summary of the research activities during 1977 is presented. The following headings are given: Atomic and Molecular Physics, Surface Physics, Nuclear Physics, Nuclear Theory, Exotic Atoms, and instrumentation and Methods. Lists of publications, seminars, conferences, and personnel are given

High radiofrequency radiation at Stockholm Old Town: An exposimeter study including the Royal Castle, Supreme Court, three major squares and the Swedish Parliament

OpenAIRE

Hardell, Lennart; Carlberg, Michael; Koppel, Tarmo; Hedendahl, Lena

2017-01-01

Exposure to radiofrequency (RF) radiation was classified as a possible human carcinogen, Group 2B, by the International Agency for Research on Cancer at WHO in 2011. The exposure pattern is changing due to the rapid development of technology. Outdoor RF radiation level was measured during five tours in Stockholm Old Town in April, 2016 using the EME Spy 200 exposimeter with 20 predefined frequencies. The results were based on 10,437 samples in total. The mean level of the total RF radiation w...

Radiation doses to patients at dental radiography

Energy Technology Data Exchange (ETDEWEB)

Paulusson-Odenhagen, M

1975-11-01

An investigation about the technique and the equipment at x-ray investigations and the distribution of the radiation doses to the thyroid and the gonads has been made in the dental policlinics belonging to the county council of the province of Stockholm. This investigation, which was suggested by the National Institute of Radiation Protection and the faculty of odontology in Stockholm, consisted of on one hand a distributed questionnaire and on the other visits. The questionnaire was distributed to all dentists (altogether 343) belonging to the dental policlinics of the county council of the province of Stockholm. 22 dentists of these were visited.

Decreasing incidence of malignant tumors of the paranasal sinuses in Sweden. An analysis of 141 consecutive cases at Karolinska Hospital from 1960 to 1980.

Science.gov (United States)

Norlander, Tomas; Frödin, Jan-Erik; Silfverswärd, Claes; Anggård, Anders

2003-03-01

We reviewed 141 cases of paranasal sinus tumors treated at Karolinska Hospital from 1960 to 1980. Of these tumors, 100 were located in the maxillary sinus, 32 in the ethmoidal sinuses, 8 in both the ethmoidal and maxillary regions, and 1 in the sphenoidal sinus. The male-to-female ratio was 2.1 to 1. Squamous cell carcinoma and adenocarcinoma were the most frequent types of tumors (55% and 13%, respectively). Treatment included surgery, irradiation, or both. The 5-year survival rate was 34% for squamous cell carcinomas and 64% for adenocarcinomas. When compared to a previous material of patients treated at the same hospital from 1940 to 1950, the proportion of poorly differentiated squamous cell carcinomas had increased significantly. The age-adjusted incidence rate decreased from 1.2 to 0.4 for male patients and from 0.7 to 0.3 for female patients between 1960 and 1980. We conclude that the incidence of malignant paranasal sinus tumors has decreased, and that squamous cell tumors now seem to be generally less differentiated than they were 50 years ago.

Health risk evaluation of certain compounds found in contaminated soil

International Nuclear Information System (INIS)

Dock, L.; Victorin, K.; Vahter, M.; Ahlborg, U.G.

1991-01-01

As part of a redevelopment plan for an old gas works site in Stockholm, the Institute of Environmental Medicine (IEM) at the Karolinska Institute was asked to evaluate the health risks associated with exposure to coal tar, containing polycyclic aromatic hydrocarbons (PAH), phenols, cyanides, sulfur compounds, arsenic, lead, cadmium and mercury in soil and to suggest guide line values for these compounds in residential areas. Our health risk evaluation was limited to possible effects following direct exposure to contaminated soil. Indirect exposure, i.e. through contaminated ground water or home-grown vegetables, was not considered, nor were effects on building material. The routes of exposure considered were ingestion, dermal contact and inhalation of soil dust. Small children were considered the primary risk group. The critical health effect associated with dermal exposure to PAH in soil is skin cancer. Ingestion of phenols, cyanides and sulphur compounds may cause acute health effects. Recommended guide line values for these contaminants were generally obtained by dividing the lowest observed effect levels with appropriate safety factors. The metals considered may cause both acute and chronic health effects. The guide line values for cadmium and mercury in soil were set based on a maximum intake through ingestion of soil corresponding to 10% of the provisional tolerable weekly intake levels (PTWI) set by FAO/WHO. For arsenic, the guide line value corresponds to 5% of the PTWI-value for a child. The suggested guide line level for lead was based on studied on the association between soil lead concentration and blood lead levels in children. The suggested guide line level for lead in soil may increase the blood-lead in a child by less than 10%. (31 refs.) (au)

Nurse staffing and education and hospital mortality in nine European countries: a retrospective observational study.

Science.gov (United States)

Aiken, Linda H; Sloane, Douglas M; Bruyneel, Luk; Van den Heede, Koen; Griffiths, Peter; Busse, Reinhard; Diomidous, Marianna; Kinnunen, Juha; Kózka, Maria; Lesaffre, Emmanuel; McHugh, Matthew D; Moreno-Casbas, M T; Rafferty, Anne Marie; Schwendimann, Rene; Scott, P Anne; Tishelman, Carol; van Achterberg, Theo; Sermeus, Walter

2014-05-24

for an average of eight patients. Nurse staffing cuts to save money might adversely affect patient outcomes. An increased emphasis on bachelor's education for nurses could reduce preventable hospital deaths. European Union's Seventh Framework Programme, National Institute of Nursing Research, National Institutes of Health, the Norwegian Nurses Organisation and the Norwegian Knowledge Centre for the Health Services, Swedish Association of Health Professionals, the regional agreement on medical training and clinical research between Stockholm County Council and Karolinska Institutet, Committee for Health and Caring Sciences and Strategic Research Program in Care Sciences at Karolinska Institutet, Spanish Ministry of Science and Innovation. Copyright © 2014 Elsevier Ltd. All rights reserved.

Enhanced glucose metabolism in cultured human skeletal muscle after Roux-en-Y gastric bypass surgery.

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Nascimento, Emmani B M; Riedl, Isabelle; Jiang, Lake Qunfeng; Kulkarni, Sameer S; Näslund, Erik; Krook, Anna

2015-01-01

Roux-en-Y gastric bypass (RYGB) surgery rapidly increases whole body insulin sensitivity, with changes in several organs including skeletal muscle. Objectives were to determine whether improvements in insulin action in skeletal muscle may occur directly at the level of the myocyte or secondarily from changes in systemic factors associated with weight loss. Myotubes were derived before and after RYGB surgery. The setting was Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden. Eight patients (body mass index (BMI) 41.8 kg/m(2); age 41 yr) underwent RYGB surgery. Before and 6 months after RYGB surgery, skeletal muscle biopsies were collected from vastus lateralis muscle. Satellite cells derived from skeletal muscle biopsies were propagated in vitro as myoblasts and differentiated into myotubes. Expression of myogenic markers is increased in myoblasts derived from biopsies taken 6 months after bypass surgery, compared with their respective presurgery condition. Furthermore, glycogen synthesis, tyrosine phosphorylation of insulin receptor (IRS)-1-Tyr612 and Interleukin (IL)-8 secretion were increased, while fatty acid oxidation and circulating IL8 levels remain unaltered. Myotubes derived from muscle biopsies obtained after RYGB surgery displayed increased insulin-stimulated phosphorylation of protein kinase B (PKB)-Thr308 and proline-rich Akt substrate of 40 kDa (PRAS40)-Thr246. RYGB surgery is accompanied by enhanced glucose metabolism and insulin signaling, altered IL8 secretion and changes in mRNA levels and myogenic markers in cultured skeletal muscle cells. Thus, RYGB surgery involves intrinsic reprogramming of skeletal muscle to increase peripheral insulin sensitivity and glucose metabolism. Copyright © 2015 American Society for Bariatric Surgery. Published by Elsevier Inc. All rights reserved.

Century Perspective of Heavy Metal Use in Urban Areas. A Case Study in Stockholm

International Nuclear Information System (INIS)

Soerme, L.; Bergbaeck, B.; Lohm, U.

2001-01-01

The inflow and stock (amount in use) of heavy metals (cadmium(Cd), chromium (Cr), copper (Cu), lead (Pb), mercury (Hg), nickel (Ni) and zinc (Zn)) in goods in 1995 have been quantified in the anthroposphere of Stockholm, Sweden. Statistics on national, regional and local level were used. Contacts were established with representatives from production and construction in the industrial sector and with authorities. The results show that the stock of Cd is 0,2 kg per capita. For the other heavy metals the corresponding result per capita is: Cr 8, Cu 170, Hg 0,01, Ni 4, Pb 73 and Zn 40 kg. The inflow varies between2-8%of the stock indicating the importance of the stock. The lowest levels are for Cu and Pb. Heavy metal levels in solid waste are high, between 15-45% of the amount in the inflow (Hg excluded), the lowest values were for Cu and Pb. Thus, recycling is incomplete. Long life expectancy goods form the majority of the stock but there is a tendency that short life expectancy goods increase their importance in the inflow. Concealed goods are also more frequent in inflow than in the stock

Radiofrequency radiation at Stockholm Central Railway Station in Sweden and some medical aspects on public exposure to RF fields.

Science.gov (United States)

Hardell, Lennart; Koppel, Tarmo; Carlberg, Michael; Ahonen, Mikko; Hedendahl, Lena

2016-10-01

The Stockholm Central Railway Station in Sweden was investigated for public radiofrequency (RF) radiation exposure. The exposimeter EME Spy 200 was used to collect the RF exposure data across the railway station. The exposimeter covers 20 different radiofrequency bands from 88 to 5,850 MHz. In total 1,669 data points were recorded. The median value for total exposure was 921 µW/m2 (or 0.092 µW/cm2; 1 µW/m2=0.0001 µW/cm2) with some outliers over 95,544 µW/m2 (6 V/m, upper detection limit). The mean total RF radiation level varied between 2,817 to 4,891 µW/m2 for each walking round. High mean measurements were obtained for GSM + UMTS 900 downlink varying between 1,165 and 2,075 µW/m2. High levels were also obtained for UMTS 2100 downlink; 442 to 1,632 µW/m2. Also LTE 800 downlink, GSM 1800 downlink, and LTE 2600 downlink were in the higher range of measurements. Hot spots were identified, for example close to a wall mounted base station yielding over 95,544 µW/m2 and thus exceeding the exposimeter's detection limit. Almost all of the total measured levels were above the precautionary target level of 3-6 µW/m2 as proposed by the BioInitiative Working Group in 2012. That target level was one-tenth of the scientific benchmark providing a safety margin either for children, or chronic exposure conditions. We compare the levels of RF radiation exposures identified in the present study to published scientific results reporting adverse biological effects and health harm at levels equivalent to, or below those measured in this Stockholm Central Railway Station project. It should be noted that these RF radiation levels give transient exposure, since people are generally passing through the areas tested, except for subsets of people who are there for hours each day of work.

Critical appraisal of the role of fingolimod in the treatment of multiple sclerosis

Directory of Open Access Journals (Sweden)

Warnke C

2011-09-01

Full Text Available Clemens Warnke1,2, Olaf Stüve3,4, Hans-Peter Hartung1, Anna Fogdell-Hahn2, Bernd C Kieseier11Department of Neurology, Heinrich-Heine-University, Düsseldorf, Germany; 2Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden; 3Department of Neurology, Dallas Veterans Affairs Medical Center, TX, USA; 4Department of Neurology, University of Texas Southwestern Medical Center at Dallas, TX, USAAbstract: This review summarizes Phase III clinical trial data available for fingolimod. The main purpose is to evaluate the benefit-risk profile of fingolimod, the first oral compound available for treatment of multiple sclerosis (MS and just recently approved by the European authorities. The authors place this evaluation in the context of the known safety and efficacy profile of established compounds for therapy of MS to outline the current and future potential of fingolimod. The authors conclude that only long-term safety data from post-marketing surveillance plans, together with additional head-to-head studies, would allow evidence-based treatment decisions. Furthermore, risk-profile analyses including patient history, exposure data to certain pathogens, and genetic analyses may potentially help to choose the right drug for individual patients in the future. Until these approaches toward an individualized medicine have been validated, treatment decisions for one or the other compound will have to be based partly on class IV evidence. Therefore, a close dialog with the well-informed patient, secured by effective risk mitigation plans, is required to choose the compound.Keywords: FTY720, oral drug, spingosine 1-phosphate receptor

Milestones in Nordic Health Promotion research.

Science.gov (United States)

Haglund, Bo J A; Tillgren, Per

2018-02-01

Based on the storytelling tradition and analyses of conference material, this article provides an overview of the evolving Nordic Health Promotion Research Network (NHPRN) and its conferences over the last 20 years. The story goes from the planning of the first conference in Bergen, Norway, back in 1996 to the eighth conference in Jyväskylä, Finland, in 2016. There have been three phases of development. During the first phase, 1996-2007, the five first conferences were initiated and implemented by departments of public health in the Nordic countries. The World Health Organization (WHO) collaborative centres of Health Promotion in Bergen University and a group at Karolinska Institute, Department of Social Medicine, creating supportive environments for health in Stockholm played key roles in initiating and supporting NHPRN. During the second phase, 2007-2014, the network was strengthened and supported by the Nordic School of Public Health (NHV) in Gothenburg. The third phase started when NHV closed down in 2015 and networking activities were transferred to the European Office of WHO in Copenhagen. The Nordic Health Promotion Research Conference series has served several purposes and will continue to do so. They are important Nordic meeting places, stimulating Health Promotion research, as well as explicitly managing ongoing concerns in the international Health Promotion community. This is reflected in the shift of foci over time. The content of the conferences has been highly responsive to whatever challenges are particularly relevant at different points in time, while also contributing to developing Health Promotion as a discipline, given that every conference has built on the previous ones.

Effect of tamsulosin versus prazosin on clinical and urodynamic parameters in women with voiding difficulty: a randomized clinical trial

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Sakineh Hajebrahimi

2011-01-01

Full Text Available Sakineh Hajebrahimi1, Yadollah Ahmadi Asrbadr1, Arash Azaripour1, Homayoun Sadeghi-Bazargani2,31Urology Department, Imam Reza University Hospital, Tabriz, Iran; 2Neuroscience Research Center and RDCC, Tabriz University of Medical Sciences, Tabriz, Iran; 3Karolinska Institute, Stockholm, SwedenObjective: To compare the effects of tamsulosin and prazosin on clinical and urodynamic parameters in women with voiding dysfunction.Methods: Forty women aged 20–65 years with a clinical diagnosis of voiding dysfunction were blindly randomized to two equal groups for treatment with tamsulosin 0.4 mg or 1–2 mg of prazosin daily. Symptom assessment with the American Urological Association Symptom Score (AUASS and urodynamic evaluation was performed initially and after three months of treatment. Patient satisfaction was evaluated and severe adverse drug effects recorded. Statistical analysis was carried out using the Student’s t-test and Mann–Whitney U test.Results: Although AUASS improved in both groups, the rate of improvement was larger in the tamsulosin group. Urodynamic parameters improved but did not normalize in both groups. Adverse side effects from medication in the prazosin group were more common than in the tamsulosin group. Most of the patients in the tamsulosin group (80% were satisfied with their treatment compared with those in the prazosin group (45%.Conclusion: Tamsulosin and prazosin are both effective in palliating symptoms of women with voiding dysfunction and improving their urodynamic parameters. Tamsulosin may be the preferred drug to prescribe because of its more amenable side effect profile and greater patient satisfaction.Keywords: tamsulosin, prazosin, voiding dysfunction 

My journey to DNA repair.

Science.gov (United States)

Lindahl, Tomas

2013-02-01

I completed my medical studies at the Karolinska Institute in Stockholm but have always been devoted to basic research. My longstanding interest is to understand fundamental DNA repair mechanisms in the fields of cancer therapy, inherited human genetic disorders and ancient DNA. I initially measured DNA decay, including rates of base loss and cytosine deamination. I have discovered several important DNA repair proteins and determined their mechanisms of action. The discovery of uracil-DNA glycosylase defined a new category of repair enzymes with each specialized for different types of DNA damage. The base excision repair pathway was first reconstituted with human proteins in my group. Cell-free analysis for mammalian nucleotide excision repair of DNA was also developed in my laboratory. I found multiple distinct DNA ligases in mammalian cells, and led the first genetic and biochemical work on DNA ligases I, III and IV. I discovered the mammalian exonucleases DNase III (TREX1) and IV (FEN1). Interestingly, expression of TREX1 was altered in some human autoimmune diseases. I also showed that the mutagenic DNA adduct O(6)-methylguanine (O(6)mG) is repaired without removing the guanine from DNA, identifying a surprising mechanism by which the methyl group is transferred to a residue in the repair protein itself. A further novel process of DNA repair discovered by my research group is the action of AlkB as an iron-dependent enzyme carrying out oxidative demethylation. Copyright © 2013. Production and hosting by Elsevier Ltd.

The web cast of the Nobel Prize of Physics of 2008, transmitted direct from Stockholm to the Globe of Science at CERN. Followed by a discussion among CERN theorists, with the participation of Jack Steinberger and John Ellis.

CERN Multimedia

Claudia Marcelloni

2008-01-01

The web cast of the Nobel Prize of Physics of 2008, transmitted direct from Stockholm to the Globe of Science at CERN. Followed by a discussion among CERN theorists, with the participation of Jack Steinberger and John Ellis.

Construction and evaluation of a self rating scale for stress-induced exhaustion disorder, the Karolinska Exhaustion Disorder Scale.

Science.gov (United States)

Besèr, Aniella; Sorjonen, Kimmo; Wahlberg, Kristina; Peterson, Ulla; Nygren, Ake; Asberg, Marie

2014-02-01

Prolonged stress (≥ six months) may cause a condition which has been named exhaustion disorder (ED) with ICD-10 code F43.8. ED is characterised by exhaustion, cognitive problems, poor sleep and reduced tolerance to further stress. ED can cause long term disability and depressive symptoms may develop. The aim was to construct and evaluate a self-rating scale, the Karolinska Exhaustion Disorder Scale (KEDS), for the assessment of ED symptoms. A second aim was to examine the relationship between self-rated symptoms of ED, depression, and anxiety using KEDS and the Hospital Anxiety and Depression Scale (HAD). Items were selected based on their correspondence to criteria for ED as formulated by the Swedish National Board of Health and Welfare (NBHW), with seven response alternatives in a Likert-format. Self-ratings performed by 317 clinically assessed participants were used to analyse the scale's psychometric properties. KEDS consists of nine items with a scale range of 0-54. Receiver operating characteristics analysis demonstrated that a cut-off score of 19 was accompanied by high sensitivity and specificity (each above 95%) in the discrimination between healthy subjects and patients with ED. Reliability was satisfactory and confirmatory factor analysis revealed that ED, depression and anxiety are best regarded as different phenomena. KEDS may be a useful tool in the assessment of symptoms of Exhaustion Disorder in clinical as well as research settings. There is evidence that the symptom clusters of ED, anxiety and depression, respectively, reflect three different underlying dimensions. © 2013 The Authors. Scandinavian Journal of Psychology published by Scandinavian Psychological Associations and John Wiley & Sons Ltd.

Stem cells: a model for screening, discovery and development of drugs

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Kitambi SS

2011-09-01

Full Text Available Satish Srinivas Kitambi1, Gayathri Chandrasekar21Department of Medical Biochemistry and Biophysics; 2Department of Biosciences, Karolinska Institutet, Stockholm, SwedenAbstract: The identification of normal and cancerous stem cells and the recent advances made in isolation and culture of stem cells have rapidly gained attention in the field of drug discovery and regenerative medicine. The prospect of performing screens aimed at proliferation, directed differentiation, and toxicity and efficacy studies using stem cells offers a reliable platform for the drug discovery process. Advances made in the generation of induced pluripotent stem cells from normal or diseased tissue serves as a platform to perform drug screens aimed at developing cell-based therapies against conditions like Parkinson's disease and diabetes. This review discusses the application of stem cells and cancer stem cells in drug screening and their role in complementing, reducing, and replacing animal testing. In addition to this, target identification and major advances in the field of personalized medicine using induced pluripotent cells are also discussed.Keywords: therapeutics, stem cells, cancer stem cells, screening models, drug development, high throughput screening

Sensitivity of a Remote Alpine System to the Stockholm and LRTAP Regulations in POP Emissions

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Barend L. van Drooge

2014-04-01

Full Text Available Persistent Organic Pollutants (POPs have been restricted and prohibited at national level for several decades now and since the 21st century at international level under the Stockholm Convention and the Convention of Long-Range Transboundary Air Pollution (LRTAP. A high mountain lake sediment core was sampled in the Alps (Gossenköllesee in summer 2010 and analyzed on POPs to examine whether the expected decreasing trends due to the implementation of the international Conventions could be observed. Higher POPs concentrations were observed in the sections corresponding to the period of large scale production and usage. p,p’-DDE and p,p’-DDD showed maximum concentrations in the core sections corresponding to the 1970s. These concentrations decreased to more or less constant levels in the top sediments, which is in agreement with the timing of past usage and banning of this pesticide. On the other hand, PCBs and HCB peaked in 1980s and the concentrations fluctuated afterwards. These observed profiles suggest that the studied site is still under influence of primary or secondary emissions and that the regulations of the international Conventions have still not been noticed in this site.

Astronomical ephemerides, navigation and war. The astonishing cooperation of the ephemeris institutes of Germany, England, France and the USA during the Second World War based on documents in the archives of the Astronomisches Rechen-Institut. Edition of the documents. (German Title: Astronomische Ephemeriden, Navigation und Krieg. Die erstaunliche Zusammenarbeit der Ephemeriden-Institute von Deutschland, England, Frankreich und den USA im Zweiten Weltkrieg nach Dokumenten im Archiv des Astronomischen Rechen-Instituts. Edition der Dokumente.)

Science.gov (United States)

Wielen, Roland; Wielen, Ute

During the whole period of the Second World War, England and the USA have exchanged astronomical ephemerides with Germany, even though these data were used for the navigation of warships and aircraft and were therefore of war importance. This astonishing fact is attested by numerous documents which survived in the archives of the Astronomisches Rechen-Institut (ARI). In Germany, the exchange was even explicitly authorized by the ministry which supervised the ARI (i.e. the Reichserziehungsminister). We present here examples of ephemerides for the Sun, the Moon, planets and stars, and explain the position determination by means of astronomical data. Ephemerides were published in almanacs which were computed and issued by special ephemeris institutes. We describe the agreements on the international exchange of ephemerides which were reached in peace times, and the continuation of this exchange during the war using intermediaries in neutral countries, first in the USA (U.S. Naval Observatory, USNO), and, from 1942 onwards, in Sweden (Stockholm Observatory). Involved persons were especially H. Spencer Jones (Astronomer Royal, Greenwich), J. F. Hellweg und W. J. Eckert (USNO), B. Lindblad (Sweden), and A. Kopff (ARI). All those relevant documents which are hold in the archives of the ARI, are described and annotated in detail. Scans of these documents are presented in a separate supplement.

Diurnal salivary cortisol concentrations in Parkinson’s disease: increased total secretion and morning cortisol concentrations

Directory of Open Access Journals (Sweden)

Skogar Ö

2011-08-01

Full Text Available Ö Skogar1,4, P-A Fall2, G Hallgren3, J Lökk4, B Bringer2, M Carlsson1, U Lennartsson3, H Sandbjork3, C-J Törnhage51Department of Geriatrics, Ryhov Hospital, Jonkoping, 2Department of Geriatrics, University Hospital, Linkoping, 3Department of Neurology, Skaraborg Hospital, Skovde, 4Institute of Neurobiology, Care Sciences, and Society, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, 5Department of Pediatrics, Skaraborg Hospital, Skövde, SwedenBackground: Parkinson’s disease (PD is a chronic neurodegenerative disorder. There is limited knowledge about the function of the hypothalamic-pituitary-adrenal axis in PD. The primary aim of this prospective study was to analyze diurnal salivary cortisol concentrations in patients with PD and correlate these with age, gender, body mass index (BMI, duration of PD, and pain. The secondary aim was to compare the results with a healthy reference group.Methods: Fifty-nine PD patients, 35 women and 24 men, aged 50–79 years, were recruited. The reference group comprised healthy individuals matched for age, gender, BMI, and time point for sampling. Salivary cortisol was collected at 8 am, 1 pm, and 8 pm, and 8 am the next day using cotton-based Salivette® tubes and analyzed using Spectria® Cortisol I125. A visual analog scale was used for estimation of pain.Results: The median cortisol concentration was 16.0 (5.8–30.2 nmol/L at 8 am, 5.8 (3.0–16.4 at 1 pm, 2.8 (1.6–8.0 at 8 pm, and 14.0 (7.5–28.7 at 8 am the next day. Total secretion and rate of cortisol secretion during the day (8 am–8 pm and the concentration of cortisol on the next morning were lower (12.5 nmol/L in the reference group. No significant correlations with age, gender, BMI, duration of PD, Hoehn and Yahr score, Unified Parkinson’s Disease Rating Scale III score, gait, pain, or cortisol concentrations were found.Conclusion: The neurodegenerative changes in PD does not seem to interfere with the

The whole body counting laboratory of the Swedish Radiation Safety Authority; Straalsaekerhetsmyndighetens helkroppslaboratorium

Energy Technology Data Exchange (ETDEWEB)

del Risco Norrlid, Lilian; Oestergren, Inger

2010-03-15

One of the first whole body counting (WBC) facilities in the world sensitive enough for in vivo measurements was started by Rolf Sievert 1950 at the Radio-Physics Department at Karolinska Institute in Stockholm. During many years this was the WBC facility of the national regulatory authority and went through different modernisations along the years. During 2004-2007 the facility was rebuilt in its new location in Solna strand and the laboratory thus moved. The latter detectors, sodium iodide (NaI) scintillation detectors from the late 80's and most electronic were kept. The measurement geometry and the background conditions have changed. This report describes the new facility's characteristics and presents the results for a first round of measurements on a non-contaminated group of persons for control of Cs-137 and K-40. The background in the new facility was monitored during 2007-2009 and is stable but higher than in the former location. The cause for the higher background is related to the presence of Radon progeny in the laboratory environment due to a different ventilation system. The limits of detection are 22 Bq for Cs-137 and 300 Bq for K-40, this for a half an hour measurement of a person of 75 kg weight. Measurements were run on a control group of persons to determine the activity concentrations of Cs-137 and K-40. The control group was populated with persons who had taken part in previous control groups at the former location. The purpose was to compare the activity concentrations of K-40 at the new laboratory in Solna strand and the former laboratory at Karolinska, since it is well known that the concentration of K-40 doesn't change significantly for the same person. The comparison revealed an underestimation of K-40 for most of the cases. A correction to the activities of Cs-137 and K-40 was applied for each member of the group. The correction factor is based on the theoretical estimation of K-40, which depends on the particular length

Air freight in the Stockholm region with focus on Eskilstuna Airport

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Kjell-Åke Allan Brorsson

2016-02-01

Full Text Available Purpose: The purpose of this article is to analyse the conditions for commencing air freight operations at the regional Eskilstuna Airport in Sweden, which require investments in airport infrastructure of at least SEK 140 –180 million. Design/ methodology: The qualitative data collection for the study was carried out through open-ended interviews with representatives of airport management, staff, representatives of residents, and actors and stakeholders in the field. In addition, much written material was collected from different authorities. Document analysis was used to systematically evaluate and review the collected documents. Content analysis was applied to organize collected data into categories. Based on the reports, decisions, environmental scanning and interviews, the data have been coded and categorized in tables via thematic analysis. Findings: The major findings of the study are that Eskilstuna Airport lacks cargo facilities and has limited apron space, and that there is strong competition from four other airports in the Stockholm region. The prospects for permanent air freight operations at Eskilstuna Airport are therefore not favourable in the current situation. However, if the development of Eskilstuna Logistics Park and the concept of inter modal highway-rail transportation are successful, they could serve as a major driving force for the development of air cargo. Furthermore, with sustainable development as a guiding principle, there is great potential to develop an airport with a high standard of environmental profile. Originality/ value: My findings are of great value to managers of airports and cargo airlines, as they highlight some of the competition aspects associated with engaging in air cargo at regional airports. The study fills a gap in existing research whose main focus is environmental issues concerning airports in general.

The Good- & Socially Sustainable Street, from a Human Perspective : Focusing on the Relationship between Physical Environments and Social Life, with Hornsgatan in Stockholm as a Case Study

OpenAIRE

Thurell, Erik

2012-01-01

With over 300 years serving as a traffic route it is no wonder that Hornsgatan has the role of a major ‘artery’ in today’s Stockholm. This thesis will analyze and investigate how the street environment on Hornsgatan is affecting the people spending time on the street, and how a better street life and street quality can be brought out when it comes to enhance the social aspects for the street and its people. Through methods such as observations of the street and interviews with business owners...

Thermoregulation: Research and Clinical Applications

Science.gov (United States)

1989-08-01

NEDERGAARD The Wenner-Gren Institute, Biologihus F3, University of Stockholm, S-106 91 Stockholm (Sweden) and *Cdtedra de Bioquimica , Facultad de Quimica...heart rate and a lack of arrhythmias. This was true as the temperature dropped and reached a low of 30-32°C, as well as in the actual recovery peri...like this to establish whether the response is linear with added amount, and the actual absorbance observed on each plate is not only a function of

Traffic-related air pollution exposure and incidence of stroke in four cohorts from Stockholm.

Science.gov (United States)

Korek, Michal J; Bellander, Tom D; Lind, Tomas; Bottai, Matteo; Eneroth, Kristina M; Caracciolo, Barbara; de Faire, Ulf H; Fratiglioni, Laura; Hilding, Agneta; Leander, Karin; Magnusson, Patrik K E; Pedersen, Nancy L; Östenson, Claes-Göran; Pershagen, Göran; Penell, Johanna C

2015-01-01

We investigated the risk of stroke related to long-term ambient air pollution exposure, in particular the role of various exposure time windows, using four cohorts from Stockholm County, Sweden. In total, 22,587 individuals were recruited from 1992 to 2004 and followed until 2011. Yearly air pollution levels resulting from local road traffic emissions were assessed at participant residences using dispersion models for particulate matter (PM10) and nitrogen oxides (NOX). Cohort-specific hazard ratios were estimated for time-weighted air pollution exposure during different time windows and the incidence of stroke, adjusted for common risk factors, and then meta-analysed. Overall, 868 subjects suffered a non-fatal or fatal stroke during 238,731 person-years of follow-up. An increment of 20 μg/m(3) in estimated annual mean of road-traffic related NOX exposure at recruitment was associated with a hazard ratio of 1.16 (95% CI 0.83-1.61), with evidence of heterogeneity between the cohorts. For PM10, an increment of 10 μg/m(3) corresponded to a hazard ratio of 1.14 (95% CI 0.68-1.90). Time-window analyses did not reveal any clear induction-latency pattern. In conclusion, we found suggestive evidence of an association between long-term exposure to NOX and PM10 from local traffic and stroke at comparatively low levels of air pollution.

Substance flow analysis of polybrominated diphenyl ethers in plastic from EEE/WEEE in Nigeria in the frame of Stockholm Convention as a basis for policy advice.

Science.gov (United States)

Babayemi, Joshua; Sindiku, Omotayo; Osibanjo, Oladele; Weber, Roland

2015-10-01

This study investigated the material/substance flow of polybrominated diphenyl ethers listed in the Stockholm Convention (SC) as persistent organic pollutant (POP-PBDEs) in the most relevant plastic fractions in Nigeria. Considering the prohibition of production and the use of POP-PBDEs and knowing that these pollutants are still contained in electrical and electronic equipment (EEE) and associated wastes (WEEE), it is necessary to determine their flows, especially in developing countries with limited end-of-life management. Following the inventory approach of the SC Guidance and utilizing the existing national e-waste inventory together with monitoring data, a material/substance flow analysis was conducted using the STAN tool. Within the period of 2000 to 2010, the total import for EEE/WEEE in Category 3 and 4 was approximately 8 million tonnes (Mt) containing approximately 2.4 Mt of polymers. For the inventory year 2010, it was estimated that from these polymers, about 0.8 Mt was still in stock and 1.6 Mt has reached the end-of-life. It was also estimated that approximately 1.1 Mt has ended in dumpsites, 0.3 Mt was burned in the open, and 0.2 Mt was recycled. In the plastic fractions, 1,270 t of POP-PBDEs was contained with about 370 t still in use/stock and approximately 900 t has entered the end-of-life phase. All three major end-of-life treatments result in environmental pollution with associated exposure risk. The implementation of the Stockholm Convention represents an important opportunity to improve this management situation in Nigeria and other developing countries.

"Var Teatre"--A Pioneer Turns 40.

Science.gov (United States)

Jones, Pamela L.

1984-01-01

Describes the Stockholm Municipal Youth and Children's theatre ("Var Teatre"), an institution of 14 theatres and attendant professional staff devoted exclusively to drama activities for children and teenagers. (PD)

Relations between nature-based solutions of green-blue area accessibility and socio-economic-ethnic patterns in the urban Stockholm region

Science.gov (United States)

Goldenberg, Romain; Kalantari, Zahra; Destouni, Georgia

2017-04-01

More than half of the world's population lives in cities, a proportion expected to increase to two thirds by 2050 (United Nations (UN), 2015). In this study, we investigate the spatial relationships that may exist between income and/or nationality homogeneity/heterogeneity levels of urban populations and their accessibility to local green-blue areas as possible nature-based solutions for sustainable urban design. For this investigation, we consider as a concrete case study the urban region of Stockholm, Sweden, for which we compile and use available land-cover and vegetation density data (the latter in terms of Normalised Difference Vegetation Index, NDVI) in order to identify and assess the spatial distributions of various green-blue area types and aspects. We further combine this data with spatial distribution data for population density, income and nationality, as well as with road-network data for assessing population travel times to nearby green-blue areas within the region. The present study results converge with those of other recent studies in showing large socio-economic-ethnic segregation in the Stockholm region. Moreover, the present data combination and analysis also show large spatial differences in and important socio-economic-ethnic correlations with accessibility to local green areas and nearby water bodies. Specifically, population income and share of Swedish nationals are well correlated in this region, with increases in both of these variables implying greater possibility to choose where to live within the region. The living choices of richer and more homogeneous (primarily Swedish) population parts are then found to be areas with greater local vegetation density (local green areas as identified by high-resolution NDVI data) and greater area extent of nearby water bodies (blue areas). For comparison, no such correlation is found between increased income or Swedish nationality homogeneity and accessibility to nearby forest areas (overall green

High somatic distress with high long-term stability in selected patients with chronic depression: a 3-year follow-up of ratings with Karolinska Scales of Personality (KSP).

Science.gov (United States)

Gardner, Ann; Hällström, Tore

2004-01-01

The main aim of the present study was to investigate mean levels and long-term stability of three scales from the Karolinska Scales of Personality (KSP), assessing somatic components of anxiety proneness in selected patients with chronic depressive symptoms. The KSP was filled in by 84 patients (26 men and 58 women) with a history of or ongoing major depression and audiological, or other comorbid somatic, symptoms. Mean scores for the Somatic Anxiety, Muscular Tension and Psychasthenia scales were above two standard deviations compared to a normative group sampled from the population. The KSP was filled in at follow-up by 65 patients. The mean interval between the ratings was 3.5 years. Comparisons between the ratings of the three scales revealed no significant mean score differences, and quite high individual stability. The mean scores were significantly increased in comparisons with depressed patients in primary care suggesting that these patients with chronic depression may comprise a depressive sub-type characterized by high "somatic distress". A putative origin for the high and stable scores in the presented sub-group of depressed patients, and the concept of "personality trait" in use even for pronounced symptoms, are discussed.

Applicability of supervised discriminant analysis models to analyze astigmatism clinical trial data

Directory of Open Access Journals (Sweden)

Sedghipour MR

2012-09-01

Full Text Available Mohammad Reza Sedghipour,1 Homayoun Sadeghi-Bazargani2,31Nikoukari Ophthalmology University Hospital, Tabriz, Iran; 2Department of Statistics and Epidemiology, Neuroscience Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; 3Department of Public Health Sciences, Karolinska Institute, Stockholm, SwedenBackground: In astigmatism clinical trials where more complex measurements are common, especially in nonrandomized small sized clinical trials, there is a demand for the development and application of newer statistical methods.Methods: The source data belonged to a project on astigmatism treatment. Data were used regarding a total of 296 eyes undergoing different astigmatism treatment modalities: wavefront-guided photorefractive keratectomy, cross-cylinder photorefractive keratectomy, and monotoric (single photorefractive keratectomy. Astigmatism analysis was primarily done using the Alpins method. Prior to fitting partial least squares regression discriminant analysis, a preliminary principal component analysis was done for data overview. Through fitting the partial least squares regression discriminant analysis statistical method, various model validity and predictability measures were assessed.Results: The model found the patients treated by the wavefront method to be different from the two other treatments both in baseline and outcome measures. Also, the model found that patients treated with the cross-cylinder method versus the single method didn't appear to be different from each other. This analysis provided an opportunity to compare the three methods while including a substantial number of baseline and outcome variables.Conclusion: Partial least squares regression discriminant analysis had applicability for the statistical analysis of astigmatism clinical trials and it may be used as an adjunct or alternative analysis method in small sized clinical trials.Keywords: astigmatism, regression, partial least squares regression

Clinical Severity as a Moderator of Outcome in Psychodynamic and Dialectical Behavior Therapies for Borderline Personality Disorder.

Science.gov (United States)

Sahin, Zeynep; Vinnars, Bo; Gorman, Bernard S; Wilczek, Alexander; Åsberg, Marie; Barber, Jacques P

2017-12-14

The aim of the present study was to assess the effect of initial level of psychiatric severity on treatment outcome in psychodynamic therapy and dialectical behavior therapy (DBT) for borderline personality disorder (BPD). It was hypothesized that DBT would lead to better outcome for patients with high psychiatric severity, whereas dynamic treatment would lead to better outcome for patients with lower psychiatric severity. Data from the 5th-year follow-up of the Stockholm City Council's and the Karolinska Institute's Psychotherapy Project were used in the present study. A total of 106 female patients diagnosed with BPD with at least 2 past suicide attempts were randomized into object-relational psychotherapy (ORP; based on transference-focused psychotherapy), DBT, and treatment as usual. Patients' baseline global severity index was used as a moderator. Global Assessment of Functioning (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition [American Psychiatric Association, 1994]) was used to examine outcome. There was a significant 3-way interaction of Time × Treatment × Severity. Post hoc analyses suggested that patients with lower levels of severity had significantly better outcomes in object-relational psychotherapy. For patients with higher severity, the 3 treatments resulted in similar outcomes in terms of level of functioning. Outcome of treatment for BPD might differ significantly for patients depending on their initial levels of overall psychiatric severity. If our findings are replicated for patients with low severity and supported for a high-severity sample, psychiatric severity can be used as a low-cost and effective tool to match patients with BPD to optimal treatments. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

Fusion research at the Royal Institute of Technology in Stockholm 1977

International Nuclear Information System (INIS)

Lehnert, B.

1976-12-01

Reviews are given on the research activities in plasma physics and controlled fusion during 1976 as well as on the plans for research in 1977, including short descriptions and motivations of the lines of approach being conducted by the laboratory. These lines include plasma-neutral gas interaction and stability, also with special approaches to plasma stabilization, magnetic confinement being mainly produced by poloidal fields, as well as heating and diagnostics of impermeable plasmas. (Auth.)

Fusion research at the Royal Institute of Technology in Stockholm 1978

International Nuclear Information System (INIS)

Lehnert, B.

1978-01-01

Summaries are given on the research activities in plasma physics and controlled fusion during 1977, and on the plans for research in 1978. The research programme includes investigations on plasma-neutral gas interaction and stability, magnetic confinement being mainly produced by poloidal fields, plasma heating, and reactor technology. (author)

Energy Drink vs. Coffee: The Effects on Levels of Alertness in Fatigued Individuals

Science.gov (United States)

2013-06-01

energy drink. After 30 minutes, each subject repeated the subjective and cognitive testing. The Karolinska sleepiness scale (KSS) was used for...Nakata A, Otsuka Y, Haratani T, et al. Validation of the Karolinska sleepiness scale against performance and EEG variables. Clin Neurophysiol 2006...KSS Karolinska sleepiness scale PDA personal digital assistant PVT psychomotor vigilance task VAS visual analog scale

Studies on catecholamine function in human fat cells

OpenAIRE

Hellström, Lena

1996-01-01

Catecholamine function in human fat cells Lena Hellström, Centre for Metabolism and Endocrinology, Department of Medicine, Huddinge University Hospital, Karolinska Institute, S-141 86 Huddinge, Sweden Human adipose tissue is a heterogeneous organ as regards metabolism. The effects of catecholamines, the main lipolytic hormones in man vary considerably in different regions. Fat cell lipolysis also changes in a number of physiological and pathophysiological states...

Karolinske psychodynamic profile (KAPP)

DEFF Research Database (Denmark)

Mathiesen, Birgit Bork; Søgaard, Ulf

2006-01-01

psykologiske testmetoder, assesment, Karolinska psychodynamic profile (KAPP), psykodynamisk profil......psykologiske testmetoder, assesment, Karolinska psychodynamic profile (KAPP), psykodynamisk profil...

Changing Public and Private Roles in the Dutch Child-Care Sector

NARCIS (Netherlands)

Plantinga, Mirjam; Plantenga, Janneke; Siegers, Jacques; Knol, Hans

2005-01-01

In the session ‘Balancing Public and Private Roles in Care for the Elderly (developed countries)’ at the World Congress of the International Institute of Sociology in Stockholm, Sweden, July 5-9, 2005.

Evidence for leptonic CP phase from NOνA, T2K and ICAL

Indian Academy of Sciences (India)

Nangal, post-Sumel, via-Jamdoli, Jaipur 302 031, India. 3Department of Theoretical Physics, School of Engineering Sciences, KTH Royal Institute of. Technology – AlbaNova University Center, Roslagstullsbacken 21, 106 91 Stockholm, Sweden.

Depoliticising the political: Market solutions and the retreat of Swedish institutional drug treatment from state management.

Science.gov (United States)

Edman, Johan

2016-06-01

This article examines developments in the Swedish drug treatment services in 1982-2000 and explores the ways in which political initiatives and the state administration's management have contributed to the major privatisations of institutional drug treatment during this period. The empirical basis for the textual analysis lies in official reports, parliamentary material and archived records from the Stockholm County Administrative Board's management of treatment facilities. The major privatisations of drug treatment services in the 1980s were both unintentional and unwanted and mainly arose from a lack of bureaucratic control and ideological anchorage. The privatisations were, however, reinforced by ideologically driven NPM-oriented political initiatives in the 1990s. The market-oriented treatment services have failed to fulfil the needs for diversity and availability within a publicly financed sector, which deals with unevenly informed and often socio-economically weak citizens. New management models in this field must ensure that ideological considerations are taken into account to meet politically decided goals and means. Copyright © 2016 Elsevier B.V. All rights reserved.

The potential of the infrastructural system of Hammarby Sjöstad in Stockholm, Sweden

International Nuclear Information System (INIS)

Iveroth, Sofie Pandis; Johansson, Stefan; Brandt, Nils

2013-01-01

The purpose of this paper is to explore to what extent the integrated infrastructural system in Hammarby Sjöstad, Stockholm, also named the Hammarby Model, reduces the metabolic flows of the district, and to what extent the district is self-sufficient, in terms of generated energy. Furthermore, the paper aspires to help create a deeper understanding of the system in order to guide the implementation of similar models in other districts, creating more sustainable cities. The method has been to quantify the local mass and energy flows of the model, using the secondary energy generated within Hammarby Sjöstad as basis when creating the system boundaries of the calculations. The findings demonstrate that the Hammarby Model reduces the metabolic flows of Hammarby Sjöstad but that the district is far from self-sufficient in terms of secondary energy. The conclusions of the paper are that the development of integrated infrastructural systems is one way to help create more sustainable cities. However, in order to reduce metabolic flows even further, the efficiency of the system must be improved by integrating more renewable energy sources. At the same time less energy has to be used in the households. - Highlights: • The integrated infrastructural system reduces the metabolic flows of the district. • Integrated infrastructural systems helps creating sustainable cities. • However, Hammarby Sjöstad is far from self-sufficient. • To reduce metabolic flows further, integrate more renewables. • At the same time less energy has to be used in the households

Endogenous DNA Damage and Repair Enzymes

Directory of Open Access Journals (Sweden)

Arne Klungland

2016-06-01

Full Text Available Tomas Lindahl completed his medical studies at Karolinska Institute in 1970. Yet, his work has always been dedicated to unraveling fundamental mechanisms of DNA decay and DNA repair. His research is characterized with groundbreaking discoveries on the instability of our genome, the identification of novel DNA repair activities, the characterization of DNA repair pathways, and the association to diseases, throughout his 40 years of scientific career.

Residential surface soil guidance values applied worldwide to the original 2001 Stockholm Convention POP pesticides.

Science.gov (United States)

Jennings, Aaron A; Li, Zijian

2015-09-01

Surface soil contamination is a worldwide problem. Many regulatory jurisdictions attempt to control human exposures with regulatory guidance values (RGVs) that specify a soil's maximum allowable concentration. Pesticides are important soil contaminants because of their intentional toxicity and widespread surface soil application. Worldwide, at least 174 regulatory jurisdictions from 54 United Nations member states have published more than 19,400 pesticide RGVs for at least 739 chemically unique pesticides. This manuscript examines the variability of the guidance values that are applied worldwide to the original 2001 Stockholm Convention persistent organic pollutants (POP) pesticides (Aldrin, Chlordane, DDT, Dieldrin, Endrin, Heptachlor, Mirex, and Toxaphene) for which at least 1667 RGVs have been promulgated. Results indicate that the spans of the RGVs applied to each of these pesticides vary from 6.1 orders of magnitude for Toxaphene to 10.0 orders of magnitude for Mirex. The distribution of values across these value spans resembles the distribution of lognormal random variables, but also contain non-random value clusters. Approximately 40% of all the POP RGVs fall within uncertainty bounds computed from the U.S. Environmental Protection Agency (USEPA) RGV cancer risk model. Another 22% of the values fall within uncertainty bounds computed from the USEPA's non-cancer risk model, but the cancer risk calculations yield the binding (lowest) value for all POP pesticides except Endrin. The results presented emphasize the continued need to rationalize the RGVs applied worldwide to important soil contaminants. Copyright © 2015 Elsevier Ltd. All rights reserved.

Patterns of Suicide and Other Trespassing Fatalities on State-Owned Railways in Greater Stockholm; Implications for Prevention

Directory of Open Access Journals (Sweden)

Helena Rådbo

2012-03-01

Full Text Available Each year, approximately 80–100 people are killed on state-owned railways due to train-person collisions in Sweden. Underlying causes are suicide and accidents; suicide constituting a vast majority. Earlier Swedish studies at a national level revealed a relation between population density and incident frequency, however, with places of occurrence often located to the outskirts of cities some distance away from station areas where victims can await approaching trains in seclusion. The aim of this study was to investigate whether this national pattern also applies to larger urban areas such as greater Stockholm, and to discuss preventative implications based on these observations. All registered incidents (N = 41 where people were hit or run-over by trains with a fatal outcome over the four-year period 2005–2008 were investigated. Results deviating from the national pattern include that most incidents occur at station areas, and that most victims enter the tracks from platforms. Passing express trains appear to be overrepresented, compared to commuter trains. Due to a low number of cases, our observations must be interpreted with caution. However, they imply that preventative measures in this type of area should focus on platform safety foremost, especially protection against rapid trains passing by station areas.

Comparison between RFLP and MIRU-VNTR genotyping of Mycobacterium tuberculosis strains isolated in Stockholm 2009 to 2011.

Science.gov (United States)

Jonsson, Jerker; Hoffner, Sven; Berggren, Ingela; Bruchfeld, Judith; Ghebremichael, Solomon; Pennhag, Alexandra; Groenheit, Ramona

2014-01-01

Our aim was to analyze the difference between methods for genotyping of Mycobacterium tuberculosis complex isolates. We collected genotyping results from Restriction Fragment Length Polymorphism (RFLP) and Mycobacterial Interspersed Repetitive Units-Variable Numbers of Tandem Repeat (MIRU-VNTR) in a geographically limited area (Stockholm) during a period of three years. The number and proportion of isolates belonging to clusters was reduced by 45 and 35% respectively when combining the two methods compared with using RFLP or MIRU-VNTR only. The mean size of the clusters was smaller when combining methods and smaller with RFLP compared to MIRU-VNTR. In clusters with confirmed epidemiological links RFLP coincided slightly better than MIRU-VNTR but where there was a difference, the variation in MIRU-VNTR pattern was only in a single locus. In isolates with few IS6110 bands in RFLP, MIRU-VNTR differentiated the isolates more, dividing the RFLP clusters. Since MIRU-VNTR is faster and less labour-intensive it is the method of choice for routine genotyping. In most cases it will be sufficient for epidemiological purposes but true clustering might still be considered if there are epidemiological links and the MIRU-VNTR results differ in only one of its 24 loci.

Can dispersion modeling of air pollution be improved by land-use regression? An example from Stockholm, Sweden.

Science.gov (United States)

Korek, Michal; Johansson, Christer; Svensson, Nina; Lind, Tomas; Beelen, Rob; Hoek, Gerard; Pershagen, Göran; Bellander, Tom

2017-11-01

Both dispersion modeling (DM) and land-use regression modeling (LUR) are often used for assessment of long-term air pollution exposure in epidemiological studies, but seldom in combination. We developed a hybrid DM-LUR model using 93 biweekly observations of NO x at 31 sites in greater Stockholm (Sweden). The DM was based on spatially resolved topographic, physiographic and emission data, and hourly meteorological data from a diagnostic wind model. Other data were from land use, meteorology and routine monitoring of NO x . We built a linear regression model for NO x , using a stepwise forward selection of covariates. The resulting model predicted observed NO x (R 2 =0.89) better than the DM without covariates (R 2 =0.68, P-interaction <0.001) and with minimal apparent bias. The model included (in descending order of importance) DM, traffic intensity on the nearest street, population (number of inhabitants) within 100 m radius, global radiation (direct sunlight plus diffuse or scattered light) and urban contribution to NO x levels (routine urban NO x , less routine rural NO x ). Our results indicate that there is a potential for improving estimates of air pollutant concentrations based on DM, by incorporating further spatial characteristics of the immediate surroundings, possibly accounting for imperfections in the emission data.

Cancer immunotherapy: effect of local treatment on the growth of lung metastases

Czech Academy of Sciences Publication Activity Database

Šímová, Jana; Mikyšková, Romana; Mendoza, Luis; Jandlová, Táňa; Povýšil, C.; Bubeník, Jan

2001-01-01

Roč. 54, Suppl. 1 (2001), s. 131 ISSN 0300-9475. [International Congress of Immunology /11./. 22.07.2001-27.07.2001, Stockholm] Institutional research plan: CEZ:AV0Z5052915 Subject RIV: EB - Genetics ; Molecular Biology

The role of T cell supopulations in regulation of nitric oxide prodution

Czech Academy of Sciences Publication Activity Database

Holáň, Vladimír; Krulová, Magdalena; Zajícová, Alena

2001-01-01

Roč. 54, Suppl. 1 (2001), s. 87 ISSN 0300-9475. [International Congress of Immunology /11./. 22.07.2001-27.07.2001, Stockholm] Institutional research plan: CEZ:AV0Z5052915 Subject RIV: EB - Genetics ; Molecular Biology

Baseline characteristics of patients with heart failure and preserved ejection fraction included in the Karolinska Rennes (KaRen) study.

Science.gov (United States)

Donal, Erwan; Lund, Lars H; Oger, Emmanuel; Hage, Camilla; Persson, Hans; Reynaud, Amélie; Ennezat, Pierre-Vladimir; Bauer, Fabrice; Sportouch-Dukhan, Catherine; Drouet, Elodie; Daubert, Jean-Claude; Linde, Cecilia

2014-02-01

Karolinska Rennes (KaRen) is a prospective observational study to characterize heart failure patients with preserved ejection fraction (HFpEF) and to identify prognostic factors for long-term mortality and morbidity. To report characteristics and echocardiography at entry and after 4-8 weeks of follow-up. Patients were included following an acute heart failure presentation with B-type natriuretic peptide (BNP)>100 ng/L or N-terminal pro-BNP (NT-proBNP)>300 ng/L and left ventricular ejection fraction (LVEF)>45%. The mean ± SD age of 539 included patients was 77 ± 9 years and 56% were women. Patient history included hypertension (78%), atrial tachyarrhythmia (44%), prior heart failure (40%) and anemia (37%), but left bundle branch block was rare (3.8%). Median NT-proBNP was 2448 ng/L (n=438), and median BNP 429 ng/L (n=101). Overall, 101 patients did not return for the follow-up visit, including 13 patients who died (2.4%). Apart from older age (80 ± 9 vs. 76 ± 9 years; P=0.006), there were no significant differences in baseline characteristics between patients who did and did not return for follow-up. Mean LVEF was lower at entry than follow-up (56% vs. 62%; P<0.001). At follow-up, mean E/e' was 12.9 ± 6.1, left atrial volume index 49.4±17.8mL/m(2). Mean global left ventricular longitudinal strain was -14.6 ± 3.9%; LV mass index was 126.6 ± 36.2g/m(2). Patients in KaRen were old with slight female dominance and hypertension as the most prevalent etiological factor. LVEF was preserved, but with increased LV mass and depressed LV diastolic and longitudinal systolic functions. Few patients had signs of electrical dyssynchrony (ClinicalTrials.gov.- NCT00774709). Copyright © 2014 Elsevier Masson SAS. All rights reserved.

Multi-institutional Validation Study of Commercially Available Deformable Image Registration Software for Thoracic Images

International Nuclear Information System (INIS)

Kadoya, Noriyuki; Nakajima, Yujiro; Saito, Masahide; Miyabe, Yuki; Kurooka, Masahiko; Kito, Satoshi; Fujita, Yukio; Sasaki, Motoharu; Arai, Kazuhiro; Tani, Kensuke; Yagi, Masashi; Wakita, Akihisa; Tohyama, Naoki; Jingu, Keiichi

2016-01-01

Purpose: To assess the accuracy of the commercially available deformable image registration (DIR) software for thoracic images at multiple institutions. Methods and Materials: Thoracic 4-dimensional (4D) CT images of 10 patients with esophageal or lung cancer were used. Datasets for these patients were provided by DIR-lab ( (dir-lab.com)) and included a coordinate list of anatomic landmarks (300 bronchial bifurcations) that had been manually identified. Deformable image registration was performed between the peak-inhale and -exhale images. Deformable image registration error was determined by calculating the difference at each landmark point between the displacement calculated by DIR software and that calculated by the landmark. Results: Eleven institutions participated in this study: 4 used RayStation (RaySearch Laboratories, Stockholm, Sweden), 5 used MIM Software (Cleveland, OH), and 3 used Velocity (Varian Medical Systems, Palo Alto, CA). The ranges of the average absolute registration errors over all cases were as follows: 0.48 to 1.51 mm (right-left), 0.53 to 2.86 mm (anterior-posterior), 0.85 to 4.46 mm (superior-inferior), and 1.26 to 6.20 mm (3-dimensional). For each DIR software package, the average 3-dimensional registration error (range) was as follows: RayStation, 3.28 mm (1.26-3.91 mm); MIM Software, 3.29 mm (2.17-3.61 mm); and Velocity, 5.01 mm (4.02-6.20 mm). These results demonstrate that there was moderate variation among institutions, although the DIR software was the same. Conclusions: We evaluated the commercially available DIR software using thoracic 4D-CT images from multiple centers. Our results demonstrated that DIR accuracy differed among institutions because it was dependent on both the DIR software and procedure. Our results could be helpful for establishing prospective clinical trials and for the widespread use of DIR software. In addition, for clinical care, we should try to find the optimal DIR procedure using thoracic 4D

Atmospheric corrosion effects of air pollution on materials and cultural property in Asia and Africa

CSIR Research Space (South Africa)

Foax, LJ

2008-10-01

Full Text Available This project is part of the Swedish International Development Co-operation Agency (Sida) funded Program on Regional Air Pollution in Developing Countries (RAPIDC). The Program is managed on Sida's behalf by the Stockholm Environment Institute (SEI...

On the bridge over the translational valley of death: interview with Per I Arvidsson.

Science.gov (United States)

Arvidsson, Per I

2017-06-01

Per I Arvidsson speaks to Francesca Lake, Managing Editor: Per received his PhD in organic chemistry from Gothenburg University (Sweden) in 1999, where he continued as a lecturer for a short time. Following 2 years at the ETH Zurich (Switzerland) as a postdoctoral fellow, he went on to establish an independent research group at the Department of Biochemistry and Organic Chemistry at Uppsala University (Sweden). In 2006, he joined AstraZeneca R&D Södertälje (Sweden). After 1-year in-house training for future leaders in drug discovery and development, he became team leader in Medicinal Chemistry in 2007. In 2008, he was appointed Candidate Drug Delivery team leader with responsibility for preclinical drug discoveries in several CNS and pain projects. In 2010, he became Project Director at the innovative medicine unit for CNS & Pain research in Södertälje with responsibility from lead optimization to end of Phase II for projects in the neurodegeneration area. After joining AstraZeneca, he continued to pursue academic research as Adjunct Professor in bioorganic chemistry at the Department of Biochemistry and Organic Chemistry, Uppsala University (2007-2010), and the Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry, Uppsala University (2010-2013). In 2010, he was appointed honorary professor in Pharmacy and Pharmacology at the University of KwaZulu Natal (South Africa). In 2013, he was recruited to the Karolinska Institute in Stockholm as Director of Drug Discovery & Development, to build up the National Swedish infrastructure for Drug Discovery & Development at the Science for Life Laboratory (SciLifeLab). Since 2013, he has been a part-time research professor at the College of Health Science at the University of KwaZulu Natal. He is named inventor on over 15 patent applications, and coauthor to over 100 publications, two of which have won 'most cited papers' awards.

Pregnancy weight gain by gestational age and stillbirth: a population-based cohort study.

Science.gov (United States)

Johansson, K; Hutcheon, J A; Bodnar, L M; Cnattingius, S; Stephansson, O

2017-11-21

To study the association between total and early pregnancy (gain and risk of stillbirth, stratified by early-pregnancy body mass index (BMI). Population-based cohort study. Stockholm-Gotland Region, Sweden. Pregnant women with singleton births (n = 160 560). Pregnancy weight gain was standardised into gestational age-specific z-scores. For analyses of total pregnancy weight gain, a matched design with an incidence density sampling approach was used. Findings were also contrasted with current Institute of Medicine (IOM) weight gain recommendations. Stillbirth defined as fetal death at ≥22 completed weeks of gestation. For all BMI categories, there was no statistical association between total or early pregnancy weight gain and stillbirth within the range of a weight gain z-score of -2.0 SD to +2.0 SD. Among normal-weight women, the adjusted odds ratio of stillbirth for lower (-2.0 to -1.0 SD) and higher (+1.0 to +1.9 SD) total weight gain was 0.85 (95% CI; 0.48-1.49) and 1.03 (0.60-1.77), respectively, as compared with the reference category. Further, there were no associations between total or early pregnancy weight gain and stillbirth within the range of weight gain currently recommended by the IOM. For the majority of the BMI categories, the point estimates at the extremes of weight gain values (gain and increased risks of high weight gain, but estimates were imprecise and not statistically significant. We found no associations between total or early pregnancy weight gain and stillbirth across the range of weight gain experienced by most women. There was no association between weight gain during pregnancy and stillbirth among most women. © 2017 Karolinska Institutet. BJOG: An International Journal of Obstetrics and Gynaecology published by John Wiley & Sons Ltd on behalf of Royal College of Obstetricians and Gynaecologists.

Laparoscopic cholecystectomy perioperative management: an update

Directory of Open Access Journals (Sweden)

Sellbrant I

2015-07-01

Full Text Available Irene Sellbrant,1 Gustaf Ledin,2 Jan G Jakobsson2 1Department of Anaesthesia, Capio Lundby, Gothenburg, 2Department of Anaesthesia and Intensive Care, Institution for Clinical Science, Karolinska Institutet, Danderyds Hospital, Stockholm, Sweden Abstract: Laparoscopic cholecystectomy is one of the most common general surgical procedures. The aim of the present paper is to review current evidence and well-established practice for elective laparoscopic perioperative management. There is no firm evidence for best anesthetic technique, further high quality studies assessing short as well as more protracted outcomes are needed. Preventive multi-modal analgesia, combining non-opioid analgesics, paracetamol, nonsteroidal anti-inflammatory drugs or coxib, and local anesthesia, has a long history. Local anesthesia improves postoperative pain and facilitates discharge on the day of surgery. Whether transversus abdominis plane-block has clinically important advantages compared to local infiltration analgesia needs further studies. Single intravenous dose steroid, dexamethasone, reduces postoperative nausea and vomiting, pain, and enhances the recovery process. Multi-modal analgesia is reassuringly safe thus having a positive benefit versus risk profile. Adherence to modern guidelines avoiding prolonged fasting and liberal intravenous fluid regime supports rapid recovery. The effects of CO2 insufflation must be acknowledged and low intra-abdominal pressure should be sought in order to reduce negative cardiovascular/respiratory effects. There is no firm evidence supporting heating and humidification of the insufflated gas. The potential risk for CO2/gas entrainment into vasaculture, gas emboli, or subcutaneous/intra-thoracic into the pleural space must be kept in mind. Laparoscopic cholecystectomy in ASA 1-2 patients following a multi-modal enhanced recovery protocol promotes high success rate for discharge on the day of surgery. Keywords: laparoscopic

Toxic Industrial Chemicals: A Future Weapons of Mass Destruction Threat

Science.gov (United States)

2002-05-31

1937 by Dr. Gerhard Schrader, a chemist conducting insecticide research with organophosphates (Stockholm International Peace Research Institute 1971...International Peace Research Institute 1971 and 1973). Phosgene oxime is known as “ nettle gas,” so named because of its property of intensely irritating...as a WMD. Common TICs Effects of CW Agents Organophosphate Insecticide Nerve Dimethyl Sulfate Blister Methyl Isocyanate Blood Anhydrous Ammonia

Clinical validation of immunoglobulin A nephropathy diagnosis in Swedish biopsy registers

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Jarrick S

2017-01-01

Full Text Available Simon Jarrick,1,2 Sigrid Lundberg,3,4 Adina Welander,5,6 C Michael Fored,6 Jonas F Ludvigsson2,7,8 1Department of Pediatrics, Faculty of Health and Medicine, Örebro University, 2Department of Pediatrics, Örebro University Hospital, Örebro, 3Department of Nephrology, Karolinska University Hospital, 4Department of Clinical Science, Intervention and Technology, Karolinska Institutet, 5Boston Consulting Group, 6Clinical Epidemiology Unit, Department of Medicine, 7Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; 8Division of Epidemiology and Public Health, School of Medicine, University of Nottingham, Nottingham, UK Aims: The aims of this study were to validate the diagnosis of IgA nephropathy (IgAN in Swedish biopsy registers against patient charts and to describe the clinical characteristics of patients with a biopsy indicating IgAN. Methods: This is a population-based cohort study. Out of 4,069 individuals with a renal biopsy consistent with IgAN (biopsies performed in 1974–2011, this study reviewed patient charts of a random subset of 127 individuals. Clinical and biopsy characteristics at the time of biopsy were evaluated, and positive predictive values (PPV were calculated with 95% confidence intervals (CI. Results: Out of 127 individuals with a renal biopsy consistent with IgAN, 121 had a likely or confirmed clinical diagnosis of IgAN, primary or secondary to Henoch–Schönlein purpura, yielding a PPV of 95% (95% CI =92%–99%. The median age at biopsy was 39 years (range: 4–79 years; seven patients (6% were <16 years. The male to female ratio was 2.8:1. The most common causes for consultation were macroscopic hematuria (n=37; 29%, screening (n=33; 26%, and purpura (n=14, 11%. In patients with available data, the median creatinine level was 104 µmol/L (range 26–986 µmol/L, n=110 and glomerular filtration rate 75 mL/min/1.73m² (range 5–173 mL/min/1.73m², n=114. Hypertension was

Frequency and clinical relevance of human bocavirus infection in acute exacerbations of chronic obstructive pulmonary disease

Directory of Open Access Journals (Sweden)

Felix C Ringshausen

2009-02-01

Full Text Available Felix C Ringshausen1, Ai-Yui M Tan1, Tobias Allander2, Irmgard Borg1, Umut Arinir1, Juliane Kronsbein1, Barbara M Hauptmeier1, Gerhard Schultze-Werninghaus1, Gernot Rohde11Clinical Research Group “Significance of viral infections in chronic respiratory diseases of children and adults,” University Hospital Bergmannsheil, Department of Internal Medicine III–Pneumology, Allergology and Sleep Medicine, Bochum, Germany; 2Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, and Department of Clinical Microbiology, Karolinska University Hospital, Stockholm, SwedenObjective: Human bocavirus (HBoV is a recently discovered parvovirus associated with acute respiratory tract infections in children. The objective of the present study was to determine the frequency and clinical relevance of HBoV infection in adult patients with acute exacerbation of chronic obstructive pulmonary disease (AE-COPD.Methods: We retrospectively tested 212 COPD patients, 141 (66.5% with AE-COPD and 71 (33.5% with stable disease, of whom nasal lavage and induced sputum had been obtained for the presence of HBoV deoxyribonucleic acid (DNA. The specificity of positive polymerase chain reaction results was confirmed by sequencing.Results: Two hundred two of 212 patients for whom PCR results were available both for nasal lavage and induced sputum samples were eligible for data analysis. HBoV DNA was detected in three patients (1.5%. Of those, only one patient had AE-COPD. Thus, the frequency of HBoV infection demonstrated to be low in both AE-COPD (0.8% and stable COPD (2.9%. HBoV was found in two sputum and one nasal lavage sample in different patients, respectively. Sequencing revealed >99% sequence identity with the reference strain.Conclusion: HBoV detection was infrequent. Since we detected HBoV in both upper and lower respiratory tract specimens and in AE-COPD as well as stable disease, a major role of HBoV infection in adults with AE-COPD is unlikely

The risk of renal disease is increased in lambda myeloma with bone marrow amyloid deposits

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Kozlowski P

2017-03-01

Full Text Available Piotr Kozlowski,1 Scott Montgomery,2–4 Rahel Befekadu,5 Victoria Hahn-Strömberg6 1Department of Medicine, School of Medical Sciences, Örebro University, Örebro, Sweden; 2Clinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, Örebro, Sweden; 3Clinical Epidemiology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden; 4Department of Epidemiology and Public Health, University College London, London, UK; 5Department of Transfusion Medicine, School of Medical Sciences, Örebro University, Örebro, Sweden; 6Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden Background: Light chain amyloidosis (AL is a rare deposition disease and is present in 10–15% of patients with myeloma (MM. In contrast to symptomatic AL in MM, presence of bone marrow (BM amyloid deposits (AD in MM is not connected to kidney damage. Renal AD but not BM-AD occur mostly in MM with lambda paraprotein (lambda MM. Methods: We investigated amyloid presence in BM clots taken at diagnosis in 84 patients with symptomatic MM and compared disease characteristics in MM with kappa paraprotein (kappa MM/lambda MM with and without BM-AD. Results: Lambda MM with BM-AD was compared with kappa MM without BM-AD, kappa MM with BM-AD, and lambda MM without BM-AD: lambda MM with BM-AD patients had a significantly higher mean creatinine level (4.23 mg/dL vs 1.69, 1.14, and 1.28 mg/dL, respectively and a higher proportion presented with severe kidney failure (6/11 [55%] vs 6/32 [19%], 1/22 [5%], and 3/19 [16%], respectively. Proteinuria was more common in lambda MM with BM-AD patients compared with kappa MM without BM-AD patients (8/11 [73%] vs 5/32 [16%], respectively. Conclusion: Kidney damage was more common in lambda MM with BM-AD indicating presence of renal AD. Keywords: plasma cells, neoplasms, amyloidosis, renal insufficiency, proteinuria

A Baltic Sea estuary as a phosphorus source and sink after drastic load reduction: seasonal and long-term mass balances for the Stockholm inner archipelago for 1968-2015

Science.gov (United States)

Walve, Jakob; Sandberg, Maria; Larsson, Ulf; Lännergren, Christer

2018-05-01

Internal phosphorus (P) loading from sediments, controlled by hypoxia, is often assumed to hamper the recovery of lakes and coastal areas from eutrophication. In the early 1970s, the external P load to the inner archipelago of Stockholm, Sweden (Baltic Sea), was drastically reduced by improved sewage treatment, but the internal P loading and its controlling factors have been poorly quantified. We use two slightly different four-layer box models to calculate the area's seasonal and annual P balance (input-export) and the internal P exchange with sediments in 1968-2015. For 10-20 years after the main P load reduction, there was a negative P balance, small in comparison to the external load, and probably due to release from legacy sediment P storage. Later, the stabilized, near-neutral P balance indicates no remaining internal loading from legacy P, but P retention is low, despite improved oxygen conditions. Seasonally, sediments are a P sink in spring and a P source in summer and autumn. Most of the deep-water P release from sediments in summer-autumn appears to be derived from the settled spring bloom and is exported to outer areas during winter. Oxygen consumption and P release in the deep water are generally tightly coupled, indicating limited iron control of P release. However, enhanced P release in years of deep-water hypoxia suggests some contribution from redox-sensitive P pools. Increasing deep-water temperatures that stimulate oxygen consumption rates in early summer have counteracted the effect of lowered organic matter sedimentation on oxygen concentrations. Since the P turnover time is short and legacy P small, measures to bind P in Stockholm inner archipelago sediments would primarily accumulate recent P inputs, imported from the Baltic Sea and from Lake Mälaren.

Teacher Rated School Ethos and Student Reported Bullying—A Multilevel Study of Upper Secondary Schools in Stockholm, Sweden

Science.gov (United States)

Modin, Bitte; Låftman, Sara B.; Östberg, Viveca

2017-01-01

School ethos refers to the school leadership’s purposive efforts to shape and direct the attitudes, values and behaviors needed in order to promote an active learning environment and to prevent the emergence of undesirable behaviors by creating shared meaning and common goals for the school. The aim of this study was to examine how teacher rated aspects of school ethos are linked with manifestations of bullying among 11th grade students. Five teacher-rated sub-dimensions of school ethos (staff stability, teacher morale, structure-order, student focus, and academic atmosphere) were examined in relation to student-reported perpetration of and exposure to traditional school bullying and cyberbullying. The data material combines student and teacher information from two separate data collections performed in 2016, comprising teachers and students in 58 upper secondary schools in Stockholm. Analyses showed that bullying was associated with all but one of the five sub-dimensions of school ethos, namely structure and order for dealing with bullying behaviors at the school. Results are discussed in light of this counter-intuitive finding. Our findings nevertheless lend support to the idea that the social organization of schools, as reflected in their teacher-rated ethos, can affect individual students’ attitudes in a way that prevents the emergence of bullying behavior among students. PMID:29236039

Teacher Rated School Ethos and Student Reported Bullying-A Multilevel Study of Upper Secondary Schools in Stockholm, Sweden.

Science.gov (United States)

Modin, Bitte; Låftman, Sara B; Östberg, Viveca

2017-12-13

School ethos refers to the school leadership's purposive efforts to shape and direct the attitudes, values and behaviors needed in order to promote an active learning environment and to prevent the emergence of undesirable behaviors by creating shared meaning and common goals for the school. The aim of this study was to examine how teacher rated aspects of school ethos are linked with manifestations of bullying among 11th grade students. Five teacher-rated sub-dimensions of school ethos (staff stability, teacher morale, structure-order, student focus, and academic atmosphere) were examined in relation to student-reported perpetration of and exposure to traditional school bullying and cyberbullying. The data material combines student and teacher information from two separate data collections performed in 2016, comprising teachers and students in 58 upper secondary schools in Stockholm. Analyses showed that bullying was associated with all but one of the five sub-dimensions of school ethos, namely structure and order for dealing with bullying behaviors at the school. Results are discussed in light of this counter-intuitive finding. Our findings nevertheless lend support to the idea that the social organization of schools, as reflected in their teacher-rated ethos, can affect individual students' attitudes in a way that prevents the emergence of bullying behavior among students.

Comparative Study of Local and National Media Reporting: Conflict around the TV Oak in Stockholm, Sweden

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Johan Östberg

2016-10-01

Full Text Available The TV oak (Television Oak conflict concerned felling an old tree in a wealthy area of Stockholm. The case received great public attention in different media formats with different scopes (e.g., newspapers, television, internet. The TV Oak issue involved actors with different, partly conflicting perceptions. Assuming that the relevance of urban tree management issues in particular leads to increased interest among the local audience, this paper compared differences in reporting on the TV Oak case in local and national newspapers. The comparison comprised the actors “speaking” in the newspapers, the interest roles attributed to different actors and the frames used. The empirical materials used were articles concerning the TV Oak published between October 2011 and June 2012 in one local and two national Swedish newspapers. Quantitative analysis of statements in these articles showed that the geographical scope of the newspaper was not the major driving force framing the TV Oak conflict and that variety of framings, ranging from a humanised perception of the oak to a more analytical hazard perception, were used. Differences between the interest roles allocated to different actors (e.g., in terms of victim, causer, and helper in the oak conflict showed that the framing of conflicts very much depended on single actors, in particular a high profile journalist in the national newspapers and private individuals writing letters to the editor in the local newspaper.

A prospective cohort study identifying risk factors for shoulder injuries in adolescent elite handball players: the Karolinska Handball Study (KHAST) study protocol.

Science.gov (United States)

Asker, Martin; Waldén, Markus; Källberg, Henrik; Holm, Lena W; Skillgate, Eva

2017-11-22

Handball is a physical contact sport that includes frequent overhead throwing, and this combination leads to a high rate of shoulder injuries. Several factors have been associated with shoulder injuries in overhead athletes, but strong scientific evidence is lacking for most suggested risk factors. We therefore designed the Karolinska Handball Study (KHAST) with the aim to identify risk factors for shoulder injuries in adolescent male and female elite handball players studying at handball-profiled secondary schools in Sweden. Secondary objectives are to investigate whether shoulder function changes during the competition season and whether the physical profile of the players changes during their time in secondary school. Players aged 15 to 19 years were included during the pre-season period of the 2014-2015 and the 2015-2016 seasons. At inclusion, players signed informed consent and filled in a questionnaire regarding playing position, playing level, previous handball experience, history of shoulder problems and athletic identity. Players also completed a detailed test battery at baseline evaluating the shoulder, neck and trunk. Players were then prospectively monitored weekly during the 2014-2015 and/or 2015-2016 competitive seasons regarding injuries and training/match workload. Results from the annual routine physical tests in the secondary school curriculum including bench press, deep squat, hand grip strength, clean lifts, squat jumps, counter movement jumps, handball players and a reduction of these injuries is therefore warranted. However, in order to introduce appropriate preventive measures, a detailed understanding of the underlying risk factors is needed. Our study has a high potential to identify important risk factors for shoulder injuries in adolescent elite handball players owing to a large study sample, a high response rate, data collection during consecutive seasons, and recording of potential confounding factors.

Reports from the department of plasma physics and fusion research. Index and abstracts 1986

International Nuclear Information System (INIS)

1987-03-01

The report lists titles and summaries of 13 reports in the TRITA-PFU-Series, titles of 4 articles published in journals, and titles of 4 papers contributed to conferences. The publications were published by the Royal Institute of Technology, Stockholm, Sweden. (G.B.)

Serum ALT levels as a surrogate marker for serum HBV DNA levels in HBeAg-negative pregnant women.

Science.gov (United States)

Sangfelt, Per; Von Sydow, Madeleine; Uhnoo, Ingrid; Weiland, Ola; Lindh, Gudrun; Fischler, Björn; Lindgren, Susanne; Reichard, Olle

2004-01-01

In Stockholm, Sweden, the majority of pregnant women positive for hepatitis B surface antigen (HBsAg) are hepatitis Be antigen (HBeAg) negative. Newborns to HBeAg positive mothers receive vaccination and hepatitis B immunoglobulin (HBIg). Newborns to HBeAg negative mothers receive vaccine and HBIg only if the mothers have elevated ALT levels. The aim of this study was to retrospectively evaluate ALT levels as a surrogate marker for HBV DNA levels in HBeAg negative carrier mothers. Altogether 8947 pregnant women were screened for HBV markers from 1999 to 2001 at the Virology Department, Karolinska Hospital. Among mothers screened 192 tested positive for HBsAg (2.2%). 13 of these samples could not be retrieved. Of the remaining 179 sera, 8 (4%) tested positive for HBeAg and 171 (95.5%) were HBeAg negative. Among the HBeAg negative mothers, 9 had HBV DNA levels > 10(5) copies/ml, and of these 7 had normal ALT levels indicating low sensitivity of an elevated ALT level as a surrogate marker for high HBV DNA level. Furthermore, no correlation was found between ALT and HBV DNA levels. Hence, it is concluded that the use of ALT as a surrogate marker for high viral replication in HBeAg negative mothers could be questioned.

Evaluation of Bluetooth as a replacement for cables in intensive care and surgery.

Science.gov (United States)

Wallin, Mats K E B; Wajntraub, Samson

2004-03-01

In today's intensive care and surgery, a great number of cables are attached to patients. These cables can make the care and nursing of the patient difficult. Replacing them with wireless communications technology would facilitate patient care. Bluetooth is a modern radio technology developed specifically to replace cables between different pieces of communications equipment. In this study we sought to determine whether Bluetooth is a suitable replacement for cables in intensive care and during surgery with respect to electromagnetic compatibility. The following questions were addressed: Does Bluetooth interfere with medical equipment? And does the medical equipment decrease the quality of the Bluetooth communication? A Bluetooth link, simulating a patient monitoring system, was constructed with two laptops. The prototype was then used in laboratory and clinical tests according to American standards at the Karolinska Hospital in Stockholm. The tests, which included 44 different pieces of medical equipment, indicated that Bluetooth does not cause any interference. The tests also showed that the hospital environment does not affect the Bluetooth communication negatively. Bluetooth, a new radio technology transmitting at 2.4 GHz, was tested in a clinical setting. The study showed that a single Bluetooth link was robust and electromagnetically compatible with the tested electronic medical devices.

Estimating Values of Carbon Sequestration and Nutrient Recycling in Forests: An Application to the Stockholm-Mälar Region in Sweden

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Ing-Marie Gren

2015-10-01

Full Text Available We calculate values of forest carbon sequestration and nutrient recycling applying the replacement cost method. The value is then determined as the savings in costs by the replacement of more expensive abatement measures with these ecosystem services in cost-effective climate and nutrient programs. To this end, a dynamic optimization model is constructed, which accounts for uncertainty in sequestration. It is applied to the Stockholm-Mälar region in southeast Sweden where the EU 2050 climate policy for carbon emissions and the Baltic Sea action plan for nutrient discharges are applied. The results show that the value of carbon and nutrient sequestration can correspond to approximately 0.5% of the region’s gross domestic product, or 40% of the value of productive forest. The largest part of this value is attributed to carbon sequestration because of the relative stringency in targets and expensive alternative abatement measures. However, sequestration is uncertain because of stochastic weather conditions, and when society has a large risk aversion for not attaining climate and nutrient targets, the values of the forest carbon and nutrient sequestration can approach zero.

Research on persistent organic pollutants in China on a national scale: 10 years after the enforcement of the Stockholm Convention.

Science.gov (United States)

Liu, Li-Yan; Ma, Wan-Li; Jia, Hong-Liang; Zhang, Zi-Feng; Song, Wei-Wei; Li, Yi-Fan

2016-10-01

As a signatory of the Stockholm Convention and the largest developing country, China plays a very important role in implementation of the convention to reduce and finally eliminate persistent organic pollutants (POPs) in the world. In the past ten years after the enforcement in 2004, Chinese Government and scientists have made great progress on the study of POPs. The present work aims to provide an overview on recent studies on POPs in China, with particular focus on usage/emission inventory, residue inventory, and pollution status of POPs on national scale. Several legend (old) and new target POPs were comprehensively summarized with progress on inventory. Furthermore, several national scale monitoring programs have been selected for the occurrence, spatial and temporal trends of POPs in China, which are compared with Asian data and Global data. Based on the observed results, some important scientific issues, such as the primary and secondary distribution patterns, the primary and secondary fractionations, and air-soil exchange of POPs, are also discussed. It is proposed that more studies should be carried out for the new targeted POPs in future for both the national and global interests. Copyright © 2016 Elsevier Ltd. All rights reserved.

Traditional justice and reconciliation after violent conflict: Learning ...

African Journals Online (AJOL)

after violent conflict: Learning from African experiences. Huyse, Luc and Mark Salter eds. 2008. Stockholm, International IDEA (Institute for Democracy and ... civil society. From their different vantage points they present a cross-cutting analysis on how traditional mechanisms can efficiently and effectively complement ...

Activation of cytokine production in F1 and F2 generation of miniature pigs transgenic for n-terminal part of mutated human huntingtin

Czech Academy of Sciences Publication Activity Database

Valeková, Ivona; Kupcová Skalníková, Helena; Klíma, Jiří; Juhás, Štefan; Motlík, Jan

2012-01-01

Roč. 83, Suppl 1 (2012), A16-A16 ISSN 0022-3050. [European Huntington´s disease network 2012 plenary meeting. 14.09.2012-16.09.2012, Stockholm] Institutional support: RVO:67985904 Keywords : Hutington´s disease Subject RIV: EB - Genetics ; Molecular Biology

Goods in the Anthroposphere as a Metal Emission Source A Case Study of Stockholm, Sweden

International Nuclear Information System (INIS)

Soerme, L.; Bergbaeck, B.; Lohm, U.

2001-01-01

The aim of this study was to quantify the diffuse emissions during use of metal containing goods in the capital of Sweden,Stockholm. The following metals were studied: Cadmium (Cd), Chromium (Cr), Copper (Cu), Lead (Pb), Mercury (Hg), Nickel (Ni) and Zinc (Zn).A major part of the metals are found in a protected environment where degrading processes like corrosion are most limited. However, during the lifetime of some goods the metal release to the environment is significant. The quantitatively most dominant emissions were found for Cu and Zn. The tap water system and roofs/fronts (Cu) represent goods with large exposed areas but with relatively small release rates per unit. In contrast, brake linings, aerial lines and electrical grounding (Cu) and tyres, brake linings and chemicals (Zn) are all goods with high release rates but mostly limited exposed stocks.High yearly emissions are also found for Pb, ammunition and sinkers dominate the calculated emissions totally. For Cr and Ni, stainless steel represent the major part of the stocks, but corrosion was estimated to give only a minor contribution to the emissions. Potential emission sources, i.e. stabilisers,pigments and plated goods dominate the exposed Cd stock. These emissions were not quantified due to lack of data. Hg is currently phased out, but one major source of emission, i.e. the use of amalgam, will be continuously significant for several decades. The importance of the traffic sector is obvious. The emissions from brake linings (Cu, Zn and Pb), tyres (Zn, Pb, Cr and Ni)and asphalt wear (Cu, Zn, Cr, Ni and Pb) are all of large importance for the total emission from respectively metal

Development of a center for light ion therapy and accurate tumor diagnostics at karolinska institutet and hospital

Science.gov (United States)

Brahme, Anders; Lind, Bengt K.

2002-04-01

Radiation therapy is today in a state of very rapid development with new intensity modulated treatment techniques continuously being developed. This has made intensity modulated electron and photon beams almost as powerful as conventional uniform beam proton therapy. To be able to cure also the most advanced hypoxic and radiation resistant tumors of complex local spread, intensity modulated light ion beams are really the ultimate tool and only slightly more expensive than proton therapy. The aim of the new center for ion therapy and tumor diagnostics in Stockholm is to develop radiobiologically optimized 3-dimensional pencil beam scanning techniques. Beside the "classical" approaches using low ionization density hydrogen ions (protons, but also deuterons and tritium nuclei) and high ionization density carbon ions, two new approaches will be developed. In the first one lithium or beryllium ions, that induce the least detrimental biological effect to normal tissues for a given biological effect in a small volume of the tumor, will be key particles. In the second approach, referred patients will be given a high-dose high-precision "boost" treatment with carbon or oxygen ions during one week preceding the final treatment with conventional radiations in the referring hospital. The rationale behind these approaches is to reduce the high ionization density dose to the normal tissue stroma inside the tumor and to ensure a microscopically uniform dose delivery. The principal idea of the center is to closely integrate ion therapy into the clinical routine and research of a large radiotherapy department. The light ion therapy center will therefore be combined with advanced tumor diagnostics including MR and PET-CT imaging to facilitate efficient high-precision high-dose boost treatment of remitted patients. The possibility to do 3D tumor diagnostics and 3D dose delivery verification with the same PET camera will be the ultimate step in high quality adaptive radiation therapy

2012 Year-End Report on Neurotechnologies for In-Vehicle Applications

Science.gov (United States)

2013-06-01

Karolinska Sleepiness Scale (KSS) (Akerstedt and Gillberg, 1990). Additionally, subjects were asked to verbally report their fatigue score on this...KSS Karolinska Sleepiness Scale MEG magnetoencephalography NCCF nickel-coated carbon fibers NCTU National Chiao Tung University NIH National

Teacher Rated School Ethos and Student Reported Bullying—A Multilevel Study of Upper Secondary Schools in Stockholm, Sweden

Directory of Open Access Journals (Sweden)

Bitte Modin

2017-12-01

Full Text Available School ethos refers to the school leadership’s purposive efforts to shape and direct the attitudes, values and behaviors needed in order to promote an active learning environment and to prevent the emergence of undesirable behaviors by creating shared meaning and common goals for the school. The aim of this study was to examine how teacher rated aspects of school ethos are linked with manifestations of bullying among 11th grade students. Five teacher-rated sub-dimensions of school ethos (staff stability, teacher morale, structure-order, student focus, and academic atmosphere were examined in relation to student-reported perpetration of and exposure to traditional school bullying and cyberbullying. The data material combines student and teacher information from two separate data collections performed in 2016, comprising teachers and students in 58 upper secondary schools in Stockholm. Analyses showed that bullying was associated with all but one of the five sub-dimensions of school ethos, namely structure and order for dealing with bullying behaviors at the school. Results are discussed in light of this counter-intuitive finding. Our findings nevertheless lend support to the idea that the social organization of schools, as reflected in their teacher-rated ethos, can affect individual students’ attitudes in a way that prevents the emergence of bullying behavior among students.

High radiofrequency radiation at Stockholm Old Town: An exposimeter study including the Royal Castle, Supreme Court, three major squares and the Swedish Parliament

Science.gov (United States)

Hardell, Lennart; Carlberg, Michael; Koppel, Tarmo; Hedendahl, Lena

2017-01-01

Exposure to radiofrequency (RF) radiation was classified as a possible human carcinogen, Group 2B, by the International Agency for Research on Cancer at WHO in 2011. The exposure pattern is changing due to the rapid development of technology. Outdoor RF radiation level was measured during five tours in Stockholm Old Town in April, 2016 using the EME Spy 200 exposimeter with 20 predefined frequencies. The results were based on 10,437 samples in total. The mean level of the total RF radiation was 4,293 µW/m2 (0.4293 µW/cm2). The highest mean levels were obtained for global system for mobile communications (GSM) + universal mobile telecommunications system (UMTS) 900 downlink and long-term evolution (LTE) 2600 downlink (1,558 and 1,265 µW/m2, respectively). The town squares displayed highest total mean levels, with the example of Järntorget square with 24,277 µW/m2 (min 257, max 173,302 µW/m2). These results were in large contrast to areas with lowest total exposure, such as the Supreme Court, with a mean level of 404 µW/m2 (min 20.4, max 4,088 µW/m2). In addition, measurements in the streets surrounding the Royal Castle were lower than the total for the Old Town, with a mean of 756 µW/m2 (min 0.3, max 50,967 µW/m2). The BioInitiative 2012 Report defined the scientific benchmark for possible health risks as 30–60 µW/m2. Our results of outdoor RF radiation exposure at Stockholm Old Town are significantly above that level. The mean exposure level at Järntorget square was 405-fold higher than 60 µW/m2. Our results were below the reference level on 10,000,000 µW/m2 established by the International Commission on Non-Ionizing Radiation Protection (ICNIRP), which, however, are less credible, as they do not take non-thermal effects into consideration and are not based on sound scientific evaluation. Our highest measured mean level at Järntorget was 0.24% of the ICNIRP level. A number of studies have found adverse, non-thermal (no measurable temperature

High radiofrequency radiation at Stockholm Old Town: An exposimeter study including the Royal Castle, Supreme Court, three major squares and the Swedish Parliament.

Science.gov (United States)

Hardell, Lennart; Carlberg, Michael; Koppel, Tarmo; Hedendahl, Lena

2017-04-01

Exposure to radiofrequency (RF) radiation was classified as a possible human carcinogen, Group 2B, by the International Agency for Research on Cancer at WHO in 2011. The exposure pattern is changing due to the rapid development of technology. Outdoor RF radiation level was measured during five tours in Stockholm Old Town in April, 2016 using the EME Spy 200 exposimeter with 20 predefined frequencies. The results were based on 10,437 samples in total. The mean level of the total RF radiation was 4,293 µW/m 2 (0.4293 µW/cm 2 ). The highest mean levels were obtained for global system for mobile communications (GSM) + universal mobile telecommunications system (UMTS) 900 downlink and long-term evolution (LTE) 2600 downlink (1,558 and 1,265 µW/m 2 , respectively). The town squares displayed highest total mean levels, with the example of Järntorget square with 24,277 µW/m 2 (min 257, max 173,302 µW/m 2 ). These results were in large contrast to areas with lowest total exposure, such as the Supreme Court, with a mean level of 404 µW/m 2 (min 20.4, max 4,088 µW/m 2 ). In addition, measurements in the streets surrounding the Royal Castle were lower than the total for the Old Town, with a mean of 756 µW/m 2 (min 0.3, max 50,967 µW/m 2 ). The BioInitiative 2012 Report defined the scientific benchmark for possible health risks as 30-60 µW/m 2 . Our results of outdoor RF radiation exposure at Stockholm Old Town are significantly above that level. The mean exposure level at Järntorget square was 405-fold higher than 60 µW/m 2 . Our results were below the reference level on 10,000,000 µW/m 2 established by the International Commission on Non-Ionizing Radiation Protection (ICNIRP), which, however, are less credible, as they do not take non-thermal effects into consideration and are not based on sound scientific evaluation. Our highest measured mean level at Järntorget was 0.24% of the ICNIRP level. A number of studies have found adverse, non-thermal (no measurable

Lessons from U.S. Allies in Security Cooperation with Third Countries: The Cases of Australia, France, and the United Kingdom

Science.gov (United States)

2011-01-01

Stockholm International Peace Research Institute. 49 “The Pacific Patrol Boat Project,” Semaphore : Newsletter of the Sea Power Centre Australia, No. 2...press-office/remarks-president-obama-and-prime-minister-cameron-united- kingdom-joint-press-avail “The Pacific Patrol Boat Project,” Semaphore

Genotoxic stress in fibroblasts and mesenchymal stem cells isolated form miniature pigs transgenic for N-terminal part of mutated human huntingtin.

Czech Academy of Sciences Publication Activity Database

Rausová, Petra; Šolc, Petr; Hrabáková, Rita; Klíma, Jiří; Juhásová, Jana; Juhás, Štefan; Motlík, Jan

2012-01-01

Roč. 83, Suppl. 1 (2012), A7 ISSN 0022-3050. [EHDN Plenary Meeting /7./. 14.02.2012-16.02.2012, Stockholm] R&D Projects: GA TA ČR TA01011466 Institutional support: RVO:67985904 Keywords : DNA damage * H2AX * MDC1 Subject RIV: CE - Biochemistry

Comparison of Sleep Models for Score Fatigue Model Integration

Science.gov (United States)

2015-04-01

In order to obtain sleepiness, the Karolinska Sleepiness Scale (KSS) was applied using the following equation. = − ( ∗ ) (8) Where a = 10.3... Karolinska Sleepiness Scale MSE Mean Square Error St Homeostatic sleep pressure TPM Three-Process Model U Ultradian component

Endogenous DNA Damage and Repair Enzymes: -A short summary of the scientific achievements of Tomas Lindahl, Nobel Laureate in Chemistry 2015.

Science.gov (United States)

Klungland, Arne; Yang, Yun-Gui

2016-06-01

Tomas Lindahl completed his medical studies at Karolinska Institute in 1970. Yet, his work has always been dedicated to unraveling fundamental mechanisms of DNA decay and DNA repair. His research is characterized with groundbreaking discoveries on the instability of our genome, the identification of novel DNA repair activities, the characterization of DNA repair pathways, and the association to diseases, throughout his 40 years of scientific career. Copyright © 2015 The Authors. Production and hosting by Elsevier Ltd.. All rights reserved.

Obsolete pesticide storage sites and their POP release into the environment-an Armenian case study

Czech Academy of Sciences Publication Activity Database

Dvorská, Alice; Šír, M.; Honzajková, Z.; Komprda, J.; Čupr, P.; Petrlík, J.; Anakhasyan, E.; Simonyan, L.; Kubal, M.

2012-01-01

Roč. 19, č. 6 (2012), s. 1944-1952 ISSN 0944-1344 Institutional research plan: CEZ:AV0Z60870520 Keywords : Obsolete organochlorinated pesticides * Obsolete organochlorinated pesticides * Gradient sampling * Emissions * Diffusivity-based calculations * Health risks * Stockholm Convention Subject RIV: DI - Air Pollution ; Quality Impact factor: 2.618, year: 2012

β-catenin expression in minipigs transgenic for human mutated huntingtin

Czech Academy of Sciences Publication Activity Database

Žižková, Martina; Hrabáková, Rita; Juhásová, Jana; Juhás, Štefan; Halada, Petr; Kovářová, Hana; Motlík, Jan

2012-01-01

Roč. 83, Suppl 1 (2012), A15-A16 ISSN 0022-3050. [EHDN Plenary Meeting /7./. 14.02.2012-16.02.2012, Stockholm] R&D Projects: GA TA ČR TA01011466 Institutional support: RVO:67985904 ; RVO:61388971 Keywords : beta-catenin * Huntington disease Subject RIV: CE - Biochemistry

LEAP2000: tools for sustainable energy analysis

Energy Technology Data Exchange (ETDEWEB)

Heaps, C.; Lazarus, M.; Raskin, P. [SEU-Boston, Boston, MA (USA)

2000-09-01

LEAP2000 is a collaborative initiative, led by the Boston Center for the Stockholm Environment Institute, to create a new suite of analytical software and databases for integrated energy-environment analysis. The LEAP2000 software and the Technology and Environmental Database (TED) are described. 5 refs., 5 figs.

Older patients' experiences during care transition

Directory of Open Access Journals (Sweden)

Rustad EC

2016-05-01

Full Text Available Else Cathrine Rustad,1–4 Bodil Furnes,1 Berit Seiger Cronfalk,2,5,6 Elin Dysvik1 1Department of Health Studies, Faculty of Social Sciences, University of Stavanger, Stavanger, Norway; 2Faculty of Health and Caring Sciences, Stord Haugesund University College, Stord, Norway; 3Research Network on Integrated Health Care in Western Norway, Helse Fonna Local Health Authority, Haugesund, Norway; 4Department of Clinical Medicine, Helse Fonna Local Health Authority, Haugesund, Norway; 5Palliative Research Center, Ersta Sköndal University College, Stockholm, Sweden; 6Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden Background: A fragmented health care system leads to an increased demand for continuity of care across health care levels. Research indicates age-related differences during care transition, with the oldest patients having experiences and needs that differ from those of other patients. To meet the older patients’ needs and preferences during care transition, professionals must understand their experiences.Objective: The purpose of the study was to explore how patients ≥80 years of age experienced the care transition from hospital to municipal health care services.Methods: The study has a descriptive, explorative design, using semistructured interviews. Fourteen patients aged ≥80 participated in the study. Qualitative content analysis was used to describe the individuals’ experiences during care transition.Results: Two complementary themes emerged during the analysis: “Participation depends on being invited to plan the care transition” and “Managing continuity of care represents a complex and challenging process”.Discussion: Lack of participation, insufficient information, and vague responsibilities among staff during care transition seemed to limit the continuity of care. The patients are the vulnerable part of the care transition process, although they possess important

Health in a fragile state: a five-year review of mortality patterns and trends at Somalia’s Banadir Hospital

Directory of Open Access Journals (Sweden)

Kulane A

2016-08-01

Full Text Available Asli Kulane,1 Douglas Sematimba,1 Lul M Mohamed,2 Abdirashid H Ali,2 Xin Lu1,3,4 1Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden; 2Women and Child Care Section, Banadir Maternity & Children Hospital, Mogadishu, Somalia; 3College of Information System and Management, National University of Defense Technology, Changsha, People’s Republic of China; 4Flowminder Foundation, Stockholm, Sweden Background: The recurrent civil conflict in Somalia has impeded progress toward improving health and health care, with lack of data and poor performance of health indicators. This study aimed at making inference about Banadir region by exploring morbidity and mortality trends at Banadir Hospital. This is one of the few functional hospitals during war. Methods: A retrospective analysis was conducted with data collected at Banadir Hospital for the period of January 2008–December 2012. The data were aggregated from patient records and summarized on a morbidity and mortality surveillance form with respect to age groups and stratified by sex. The main outcome was the number of patients that died in the hospital. Chi-square tests were used to evaluate the association between sex and hospital mortality. Results: Conditions of infectious origin were the major presentations at the hospital. The year 2011 recorded the highest number of cases of diarrhea and mortality due to diarrhea. The stillbirth rate declined during the study period from 272 to 48 stillbirths per 1,000 live births by 2012. The sum of total cases that were attended to at the hospital by the end of 2012 was four times the number at the baseline year of the study in 2008; however, the overall mortality rate among those admitted declined between 2008 and 2012. Conclusion: There was reduction in patient mortality at the hospital over the study period. Data from Banadir Hospital are consistent with findings from Banadir region and could give credible public health

High prevalence of extended-spectrum β-lactamase-producing pathogens: results of a surveillance study in two hospitals in Ujjain, India

Directory of Open Access Journals (Sweden)

Pathak A

2012-04-01

Full Text Available Ashish Pathak1,2, Yogyata Marothi3, Vandana Kekre4, Kalpana Mahadik5, Ragini Macaden6, Cecilia Stålsby Lundborg11Division of Global Health, Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden; 2Department of Pediatrics, 3Department of Microbiology, 4Department of Medicine, 5Department of Obstetrics and Gynecology, RD Gardi Medical College, Ujjain, India; 6St Johns Research Institute, Bangalore, IndiaBackground: Recent reports of the rapid evolution of bacterial resistance in India require urgent antibiotic stewardship programs. This study aimed to define the magnitude and pattern of resistance of bacterial pathogens to guide empirical therapy.Methods: We prospectively collected consecutive, clinically significant, and nonduplicate bacterial isolates from each patient from two hospitals in Ujjain, India. The antibiotic susceptibility of the bacteria was tested using a disc diffusion method as recommended by the Clinical and Laboratory Standards Institute.Results: A total of 716 pathogens were isolated from 2568 patients (median age, 25 years; range, 0 days to 92 years. Gram-negative infections were predominant (62%. The isolated pathogens included Staphylococcus aureus (n = 221; 31%, Escherichia coli (n = 149; 21%, Pseudomonas aeruginosa (n = 127; 18%, and Klebsiella pneumoniae (n = 107; 15%. Common diagnoses included abscesses (56%, urinary tract infections (14%, blood stream infections (10%, pneumonia (10%, and vaginal infections (10%. In E. coli isolates, 69% (95% confidence interval [CI] 61.6–76.6 were extended-spectrum β-lactamase (ESBL producers and 41% (95% CI 31.6–50.5 of K. pneumoniae isolates were ESBL producers. These isolates had a high resistance to fluoroquinolones and β-lactams, except for imipenem and piperacillin-tazobactam. Salmonella typhi remained sensitive to third-generation cephalosporins. Methicillin-resistant S. aureus (MRSA constituted 30% of all S. aureus isolates and showed resistance

Masteŕ s Programme at Stockholm University: Hydrology, Hydrogeology and Water Resources

Science.gov (United States)

Jarsjö, J.; Destouni, G.; Lyon, S. W.; Seibert, J.

2009-04-01

Many environmental risks and societal concerns are directly related to the way we manage our land and water environments. The two-year master's programme "Hydrology, Hydrogeology and Water Resources" at Stockholm University, Sweden, is based on a system perspective and provides extended knowledge about water and soil-rock-sediment systems and how these interact with each other and with land use, socio-economic and water resource policy and management systems. This water system perspective includes the spreading of dissolved substances and pollutants in various water systems and associated risks for society. Questions related to water resources are also covered: the management of water resources and conflicts as well as collaborations caused by shared water resources on local, regional and global scales. A common learning objective for the courses in the programme is to be able to identify, extract and combine relevant information from databases and scientific publications, and use the resulting dataset in hydrological, hydrogeological and water resources analyses, on local, regional or global levels. Traditional classroom teaching is to large extent complemented by case study analyses, performed as project assignments. The importance of water resources for both the society and the environment is emphasized through applications to practical water resources management challenges in society. The courses in this program include the following topics: · Hydrological and hydrogeological processes, main components of the water cycle (e.g., precipitation, evapotranspiration, discharge) and the spreading of dissolved substances and pollutants in various water systems. · Water resources and water quality, pollution spreading through surface, ground and coastal water systems, as well as vulnerability and resilience of water resources. · Regional analyses related to global water resource vulnerability and resilience. · Models and information systems as important tools for

Reproductive history and involvement in pregnancy and childbirth of fathers of babies born to teenage mothers in Stockholm, Sweden.

Science.gov (United States)

Ekeus, Cecilia; Christensson, Kyllike

2003-06-01

to describe and compare sexual and reproductive history as well as reactions to the pregnancy and attendance in antenatal care, family classes and childbirth of fathers of babies born to teenage mothers and fathers of babies born to average aged mothers. a descriptive comparative study using a structured questionnaire for data collection. eleven postnatal wards at the five obstetric and gynaecological departments in the Stockholm area. 132 fathers of babies born to primiparous teenage mothers (Group A) and the same number of fathers of babies born to primiparous women aged between 25-29 years (Group B) who were present in the postnatal wards. 43 of Group A compared to 17% of the Group B fathers had their first intercourse before 15 years of age. This early sexual debut was related to other health hazard, such as use of illicit drugs and cigarette smoking. The majority of the pregnancies in Group A were unplanned but most fathers reacted positively to the pregnancy and participated in the antenatal care. In contrast, only half of these fathers attended family classes. fathers of babies born to teenage mothers differed from fathers of babies to older mothers regarding reproductive background as well as involvement during pregnancy. The findings of this study challenge midwives to organise clinical practice in order to meet the specific needs of this group.

ADAPTIVE CAPACITY IN RURAL SOUTH AFRICA Sam Schramski

African Journals Online (AJOL)

sam schramski

2017-02-02

Feb 2, 2017 ... such as the authors of Panarchy, state that adaptive capacity is ―the ... with this definition that the ‗potential' represents a society's response to ... closely linked together in case studies on water and health (Ebi ... water insecurity; weak institutions and governance (Füssel and ...... Stockholm, Sweden, 2005.

Reproductive parameters and mitochondrial function in spermatozoa of F1 and F2 minipig boars transgenic for n-terminal part of the human mutated huntingtin

Czech Academy of Sciences Publication Activity Database

Mačáková, Monika; Hansíková, H.; Pavlok, Antonín; Hajková, Z.; Sádková, J.; Juhás, Štefan; Juhásová, Jana; Baxa, Monika; Zeman, J.; Motlík, Jan

2012-01-01

Roč. 83, Suppl 1 (2012), A16-A16 ISSN 0022-3050. [European Huntington´s disease network 2012 plenary meeting. 14.09.2012-16.09.2012, Stockholm] R&D Projects: GA TA ČR TA01011466 Institutional support: RVO:67985904 Keywords : huntingtin Subject RIV: EB - Genetics ; Molecular Biology

Consequences of 40 Years' Dioxin Intoxication

Czech Academy of Sciences Publication Activity Database

Pelclová, D.; Fenclová, Z.; Dubská, Z.; Malík, J.; Navrátil, Tomáš

2009-01-01

Roč. 47, č. 5 (2009), s. 494-494 ISSN 1556-3650. [The International Congress of the European Association of Poison Centres and Clinical Toxicologists /29./. 12.05.2009-15.05.2009, Stockholm] Institutional research plan: CEZ:AV0Z40400503 Keywords : dioxins * intoxication Subject RIV: CF - Physical ; Theoretical Chemistry

Integrating ecosystem services in the assessment of urban energy trajectories – A study of the Stockholm Region

International Nuclear Information System (INIS)

Mörtberg, Ulla; Goldenberg, Romain; Kalantari, Zahra; Kordas, Olga; Deal, Brian; Balfors, Berit; Cvetkovic, Vladimir

2017-01-01

Urban development trajectories are changing towards compact, energy-efficient cities and renewable energy sources, and this will strongly affect ecosystem services (ES) that cities are dependent on but tend to disregard. Such ES can be provisioning, regulating and cultural ES, around which competition over land resources will increase with energy system shifts. Much of this can be foreseen to take place within urbanising regions that are simultaneously the living environment of a major part of the human population today. In order to inform critical urban policy decisions, tools for integrated assessment of urban energy and transport options and ecosystem services need to be developed. For this purpose, a case study of the Stockholm region was conducted, analysing three scenarios for the future urbanisation of the region, integrating a transport energy perspective and an ES perspective. The results showed that a dense but polycentric development pattern gives more opportunities for sustainable urban development, while the dense monocentric scenario has apparent drawbacks from an ES perspective. The methodology is compatible with a model integration platform for urban policy support and will thus enable integrated policy assessment of complex urban systems, with the goal of increasing their sustainability. - Highlights: • A diffuse urban pattern leads to low access to jobs and high energy consumption. • A dense monocentric urban pattern implies high energy efficiency and low access to ES. • A dense polycentric urban pattern allows for a combination of urban functions. • ES needs to be integrated into sustainability assessments of urban policy options.

Towards a Social-Ecological Urbanism: Co-Producing Knowledge through Design in the Albano Resilient Campus Project in Stockholm

Directory of Open Access Journals (Sweden)

Hanna Erixon Aalto

2018-03-01

Full Text Available If we are to promote urban sustainability and resilience, social-ecological knowledge must be better integrated in urban planning and design projects. Due to gaps in the two cultures of thinking that are associated with the disciplines of ecology and design, such integration has, however, proven to be challenging. In mainstream practice, ecologists often act as sub-consultants; they are seldom engaged in the creative and conceptual phases of the process. Conversely, research aiming to bridge the gap between design and ecology has tended to be dominated by a relatively static and linear outlook on what the design process is, and what it could be. Further, few concrete examples of the co-production of ecological and design knowledge exist. In this paper, we give an account of a transdisciplinary design proposal for Albano Resilient Campus in Stockholm, discussing how design—seen as a process and an assemblage of artifacts—can act as a framework for co-producing knowledge and operationalizing concepts of resilience and ecosystem services. Through a design-based and action-oriented approach, we discuss how such a collaborative design process may integrate ecological knowledge into urban design through three concrete practices: (a iterative prototyping; (b generative matrix models; and, (c legible, open-ended, comprehensive narratives. In the conclusion, we sketch the contours of a social-ecological urbanism, speculating on possible broader and changed roles for ecologists, designers, and the associated actors within this framework.

Design and methods for a Scandinavian pharmacovigilance study of osteonecrosis of the jaw and serious infections among cancer patients treated with antiresorptive agents for the prevention of skeletal-related events

Directory of Open Access Journals (Sweden)

Acquavella J

2016-07-01

Full Text Available John Acquavella,1 Vera Ehrenstein,1 Morten Schiødt,2 Uffe Heide-Jørgensen,1 Anders Kjellman,3,4 Svein Hansen,5 Cecilia Larsson Wexell,6,7 Bente Brokstad Herlofson,8 Sven Erik Noerholt,9 Haijun Ma,10 Katarina Öhrling,11 Rohini K Hernandez,12 Henrik Toft Sørensen1 1Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark; 2Department of Oral and Maxillofacial Surgery, Rigshospitalet, Copenhagen, Denmark; 3Department of Urology, Karolinska University Hospital, 4Department of Clinical Science, Intervention, and Technology, Karolinska Institutet, Stockholm, Sweden; 5Cancer Registry of Norway, Oslo University Hospital, Oslo, Norway; 6Department of Oral and Maxillofacial Surgery, Södra Älvsborg Hospital, Borås, Sweden; 7Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; 8Department of Oral Surgery and Oral Medicine, Faculty of Dentistry, University of Oslo, Oslo, Norway; 9Department of Oral and Maxillofacial Surgery, Aarhus University Hospital, Aarhus, Denmark; 10Global Biostatistical Science, Amgen Inc., Thousand Oaks, CA, USA; 11Clinical Development, Amgen Inc., Thousand Oaks, CA, USA; 12Center for Observational Research, Amgen Inc., Thousand Oaks, CA, USA Objective: Osteonecrosis of the jaw (ONJ is a recognized complication of potent antiresorptive therapies, especially at the doses indicated to prevent skeletal complications for cancer patients with bone metastases. This paper describes the rationale and methods for a prospective, post-authorization safety study of cancer patients treated with antiresorptive therapies. Methods: As part of a comprehensive pharmacovigilance plan, developed with regulators’ input, the study will estimate incidence of ONJ and of serious infections among adult cancer patients with bone metastases treated with denosumab (120 mg subcutaneously or zoledronic acid (4 mg intravenously, adjusted for renal function

Fusing Multiple Sensor Modalities for Complex Physiological State Monitoring

Science.gov (United States)

2012-12-01

STDLAT has been correlated to the Karolinska Sleepiness Scale (KSS), with a chi-squared value of 11 (p < 0.001) (17). For this study, we look at the...width at half maximum GAZEDIS gaze distribution HRED Human Research and Engineering Directorate KSS Karolinska Sleepiness Scale NTSB National

Dental caries, periodontal disease, and cardiac arrhythmias in community-dwelling older persons aged 80 and older: is there a link?

DEFF Research Database (Denmark)

Holm-Pedersen, Poul; Avlund, Kirsten; Morse, Douglas E

2005-01-01

lesions had 2.8 times higher odds (95% confidence interval=1.1-7.0) of arrhythmia than persons without active coronal caries, but there was no greater risk for persons with three or more coronal caries lesions. There was no association between periodontal disease and arrhythmia. CONCLUSION: The findings......OBJECTIVES: To examine whether caries or periodontitis is associated with cardiac arrhythmias in community-dwelling people aged 80 and older. SETTING: Urban, community-based population in Stockholm, Sweden. DESIGN: Cross-sectional. PARTICIPANTS: Eligible persons were identified through...... by a physician or the Stockholm Inpatient Register. Active root caries, active coronal caries, and periodontitis were assessed using previously defined National Institute of Dental and Craniofacial Research diagnostic criteria. RESULTS: The primary finding of the multivariate logistic regression analysis...

Exploring the Top-Cited and Most Influential Articles in Medical Education.

Science.gov (United States)

Azer, Samy A

2016-01-01

The citations received by a scientific publication have been used as a proxy measurement of scientific quality and in ranking researchers. Although these practices have been observed in several institutes, careful assessment of top-cited articles may provide more insight into exploring their characteristics. The aim of this study was to analyze the top-cited articles in medical education identified by Azer 2015 and explore the characteristics of these articles that can provide insight into their assessment. The most frequently cited articles identified by searching the Web of Science under the category "Education, Scientific Discipline" were included in the analysis. The following issues were further analyzed: 1) comparing the mean yearly citations received by articles published before the year 2000 and those published after, 2) assessing whether there was a correlation between the number of grants, number of authors, number of institutes, or number of countries involved and the number of citations received, 3) assessing the number of female representation in authorship, 4) assessing the representation of none-medical staff in the authorship, and 5) exploring any association between top authors identified and those who were awarded the Karolinska Institutet Prize for research in medical education. Although there was no correlation between the number of citations and the number of years since publications, the mean number of citations received by articles published before the year 2000 varied from zero to 18.2 ± 16.6, whereas for those published after the year 2000 the mean varied from 2.0 ± 2.1 to 35.3 ± 26.8. No correlation was found between the number of citations obtained and number of grants, number of authors, number of institutes, or number of countries involved. Females comprised 50% of the total number of authors. However, no correlation was found between the number of females in authorship and the number of citations obtained. Similarly, the number of

Trial protocol: a parallel group, individually randomized clinical trial to evaluate the effect of a mobile phone application to improve sexual health among youth in Stockholm County.

Science.gov (United States)

Nielsen, Anna; De Costa, Ayesha; Bågenholm, Aspasia; Danielsson, Kristina Gemzell; Marrone, Gaetano; Boman, Jens; Salazar, Mariano; Diwan, Vinod

2018-02-05

Genital Chlamydia trachomatis infection is a major public health problem worldwide affecting mostly youth. Sweden introduced an opportunistic screening approach in 1982 accompanied by treatment, partner notification and case reporting. After an initial decline in infection rate till the mid-90s, the number of reported cases has increased over the last two decades and has now stabilized at a high level of 37,000 reported cases in Sweden per year (85% of cases in youth). Sexual risk-taking among youth is also reported to have significantly increased over the last 20 years. Mobile health (mHealth) interventions could be particularly suitable for youth and sexual health promotion as the intervention is delivered in a familiar and discrete way to a tech savvy at-risk population. This paper presents a protocol for a randomized trial to study the effect of an interactive mHealth application (app) on condom use among the youth of Stockholm. 446 youth resident in Stockholm, will be recruited in this two arm parallel group individually randomized trial. Recruitment will be from Youth Health Clinics or via the trial website. Participants will be randomized to receive either the intervention (which comprises an interactive app on safe sexual health that will be installed on their smart phones) or a control group (standard of care). Youth will be followed up for 6 months, with questionnaire responses submitted periodically via the app. Self-reported condom use over 6 months will be the primary outcome. Secondary outcomes will include presence of an infection, Chlamydia tests during the study period and proxy markers of safe sex. Analysis is by intention to treat. This trial exploits the high mobile phone usage among youth to provide a phone app intervention in the area of sexual health. If successful, the results will have implications for health service delivery and health promotion among the youth. From a methodological perspective, this trial is expected to provide

Decommissioning and decontrolling the R1-reactor

International Nuclear Information System (INIS)

Bergman, C.; Holmberg, B.T.

1985-01-01

Sweden's first nuclear reactor - the research reactor R1 - situated in bedrock under the Royal Technical Institute of Stockholm, has in the period 1981-1983 been subject to a complete decommissioning. The National Institute for Radiation Protection has followed the work in detail, and has after the completion of the decommissioning performed measurements of radioactivity on site. The report gives an account of the work the Institute has done in preparation for- and during decommissioning and specifically report on the measurements for classification of the local as free for non-nuclear use. (aa)

Interferenz von Muttersprache und Zweitsprache auf eine dritte Sprache beim freien Sprechen -- ein Vergleich (Interference by the Native Language and a Second Language on a Third Language in Free Conversation -- A Comparison)

Science.gov (United States)

Stedje, Astrid

1976-01-01

Tests given at the German Institute of the University of Stockholm to 32 Finnish students studying German revealed that both their native language and their Swedish interfered with their learning German, in about equal degree overall. The mother tongue, Finnish, caused more interference errors in pronunciation. (Text is in German.) (IFS/WGA)

Residues of Pharmaceuticals in Gastric Lavage

Czech Academy of Sciences Publication Activity Database

Pelclová, D.; Navrátil, Tomáš

2009-01-01

Roč. 47, č. 5 (2009), s. 483-483 ISSN 1556-3650. [The International Congress of the European Association of Poison Centres and Clinical Toxicologists /29./. 12.05.2009-15.05.2009, Stockholm] Institutional research plan: CEZ:AV0Z40400503 Keywords : Toxicologica Information Centre * gastric lavage Subject RIV: CF - Physical ; Theoretical Chemistry

Karolinska institutet 200-year anniversary. Symposium on traumatic injuries in the nervous system: injuries to the spinal cord and peripheral nervous system - injuries and repair, pain problems, lesions to brachial plexus.

Science.gov (United States)

Sköld, Mattias K; Svensson, Mikael; Tsao, Jack; Hultgren, Thomas; Landegren, Thomas; Carlstedt, Thomas; Cullheim, Staffan

2011-01-01

The Karolinska Institutet 200-year anniversary symposium on injuries to the spinal cord and peripheral nervous system gathered expertise in the spinal cord, spinal nerve, and peripheral nerve injury field spanning from molecular prerequisites for nerve regeneration to clinical methods in nerve repair and rehabilitation. The topics presented at the meeting covered findings on adult neural stem cells that when transplanted to the hypoglossal nucleus in the rat could integrate with its host and promote neuron survival. Studies on vascularization after intraspinal replantation of ventral nerve roots and microarray studies in ventral root replantation as a tool for mapping of biological patterns typical for neuronal regeneration were discussed. Different immune molecules in neurons and glia and their very specific roles in synapse plasticity after injury were presented. Novel strategies in repair of injured peripheral nerves with ethyl-cyanoacrylate adhesive showed functional recovery comparable to that of conventional epineural sutures. Various aspects on surgical techniques which are available to improve function of the limb, once the nerve regeneration after brachial plexus lesions and repair has reached its limit were presented. Moreover, neurogenic pain after amputation and its treatment with mirror therapy were shown to be followed by dramatic decrease in phantom limb pain. Finally clinical experiences on surgical techniques to repair avulsed spinal nerve root and the motoric as well as sensoric regain of function were presented.

Enriching Production: Perspectives on Volvo's Uddevalla plant as an alternative to lean production

OpenAIRE

Sandberg, Åke

1995-01-01

Enriching Production was first published by Avebury in 1995. The book was quickly sold out and is now made available again. Enriching Production was edited by professor Åke Sandberg, Arbetslivsinstitutet/ National Institute for Working Life and KTH The Royal Institute of Technology, Stockholm. Enriching Production was followed up by a symposium on the general theme of ‘Good work and productivity’. The papers were collected in a special issue of Economic and Industrial Democracy, Vol. 19, ...

Organic mononitrites of 1,2-propanediol act as an effective NO-releasing vasodilator in pulmonary hypertension and exhibit no cross-tolerance with nitroglycerin in anesthetized pigs

Directory of Open Access Journals (Sweden)

Nilsson KF

2018-03-01

Full Text Available Kristofer F Nilsson,1,2 Waldemar Goździk,3 Claes Frostell,4 Stanisław Zieliński,3 Marzena Zielińska,3 Kornel Ratajczak,5 Piotr Skrzypczak,5 Sylwia Rodziewicz,5 Johanna Albert,6 Lars E Gustafsson1,† 1Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden; 2Department of Cardiothoracic and Vascular Surgery, Faculty of Medicine and Health, Örebro University, Örebro, Sweden; 3Department of Anaesthesiology and Intensive Therapy, Wroclaw Medical University, Wroclaw, Poland; 4Department of Anesthesia and Intensive Care, Danderyd Hospital, Stockholm, Sweden; 5Department and Clinic of Surgery, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland; 6Department of Surgery, Danderyd Hospital, Stockholm, Sweden †Lars E Gustafsson passed away on October 04, 2017 Purpose: Clinically available intravenous (IV nitric oxide (NO donor drugs such as nitroglycerin (GTN cause systemic hypotension and/or tolerance development. In a porcine model, novel NO donor compounds – the organic mononitrites of 1,2-propanediol (PDNO – were compared to GTN with regard to pulmonary selectivity and tolerance development. The vasodilatory effects of inorganic nitrite were investigated.Materials and methods: In anesthetized piglets, central hemodynamics were monitored. At normal pulmonary vascular resistance (PVR, IV infusions of PDNO (15–60 nmol kg-1 min-1, GTN (13–132 nmol kg-1 min-1, and inorganic nitrite (dosed as PDNO were administered. At increased PVR (by U46619 IV, IV infusions of PDNO (60–240 nmol kg-1 min-1 and GTN (75–300 nmol kg-1 min-1 before and after a 5 h infusion of GTN (45 nmol kg-1 min-1 were given.Results: At normal PVR, PDNO (n=12 and GTN (n=7 caused significant dose-dependent decreases in mean systemic and pulmonary arterial pressures, whereas inorganic nitrite (n=13 had no significant effect. At increased PVR, PDNO (n=6 and GTN (n=6 significantly decreased mean systemic and pulmonary

Estnisk poesi võgar ta plats / Michel Ekman

Index Scriptorium Estoniae

Ekman, Michel

2008-01-01

Arvustus: Rooste, Jürgen. Presidenten bor nõnstans i närheten / översättning: Peeter Puide. Stockholm : Ellerströms, 2007 ; fs. 2007 / översättning: Peeter Puide. Stockholm : Ellerströms, 2007 ; Kruusa, Kalju. Mötesvis / översättning: Peeter Puide. Stockholm : Ellerströms, 2007 ; Estniska ballader / översättning: Ilmar Laaban. Stockholm : Ellerströms, 2007 ; Laaban, Ilmar. Palingarderomb. Stockholm : Ellerströms, 2007 ; Under, Marie. Gnistor i askan / översättning: Enel Melberg. Stockholm : Ellerströms, 2007 ; Wuolijoki, Hella. Sõngen om kriget / översättning: Enel Melberg. Stockholm : Ellerströms, 2007 ; Alver, Betti. Historien om den vita krõkan / översättning: Enel Melberg. Stockholm : Ellerströms, 2007 ; Kareva, Doris. Tidens gestalt / översättning: Peeter Puide. Stockholm : Ellerströms, 2007

Genetics and epigenetics of eating disorders

Directory of Open Access Journals (Sweden)

Yilmaz Z

2015-03-01

Full Text Available Zeynep Yilmaz,1 J Andrew Hardaway,1 Cynthia M Bulik1–3 1Department of Psychiatry, 2Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; 3Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden Abstract: Eating disorders (EDs are serious psychiatric conditions influenced by biological, psychological, and sociocultural factors. A better understanding of the genetics of these complex traits and the development of more sophisticated molecular biology tools have advanced our understanding of the etiology of EDs. The aim of this review is to critically evaluate the literature on the genetic research conducted on three major EDs: anorexia nervosa, bulimia nervosa, and binge eating disorder. We will first review the diagnostic criteria, clinical features, prevalence, and prognosis of anorexia nervosa, bulimia nervosa, and binge eating disorder, followed by a review of family, twin, and adoption studies. We then review the history of genetic studies of EDs covering linkage analysis, candidate-gene association studies, genome-wide association studies, and the study of rare variants in EDs. Our review also incorporates a translational perspective by covering animal models of ED-related phenotypes. Finally, we review the nascent field of epigenetics of EDs and a look forward to future directions for ED genetic research. Keywords: anorexia nervosa, binge eating disorder, bulimia nervosa, animal models, genome-wide association studies, high-throughput sequencing

Gender dysphoria in adolescence: current perspectives

Directory of Open Access Journals (Sweden)

Kaltiala-Heino R

2018-03-01

Full Text Available Riittakerttu Kaltiala-Heino,1–3 Hannah Bergman,4 Marja Työläjärvi,2 Louise Frisén4 1Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland; 2Department of Adolescent Psychiatry, Tampere University Hospital, Tampere, Finland; 3Vanha Vaasa Hospital, Vaasa, Finland; 4Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden Abstract: Increasing numbers of adolescents are seeking treatment at gender identity services in Western countries. An increasingly accepted treatment model that includes puberty suppression with gonadotropin-releasing hormone analogs starting during the early stages of puberty, cross-sex hormonal treatment starting at ~16 years of age and possibly surgical treatments in legal adulthood, is often indicated for adolescents with childhood gender dysphoria (GD that intensifies during puberty. However, virtually nothing is known regarding adolescent-onset GD, its progression and factors that influence the completion of the developmental tasks of adolescence among young people with GD and/or transgender identity. Consolidation of identity development is a central developmental goal of adolescence, but we still do not know enough about how gender identity and gender variance actually evolve. Treatment-seeking adolescents with GD present with considerable psychiatric comorbidity. There is little research on how GD and/or transgender identity are associated with completion of developmental tasks of adolescence. Keywords: gender dysphoria, gender identity, adolescence, developmental tasks

Cues of fatigue: effects of sleep deprivation on facial appearance.

Science.gov (United States)

Sundelin, Tina; Lekander, Mats; Kecklund, Göran; Van Someren, Eus J W; Olsson, Andreas; Axelsson, John

2013-09-01

To investigate the facial cues by which one recognizes that someone is sleep deprived versus not sleep deprived. Experimental laboratory study. Karolinska Institutet, Stockholm, Sweden. Forty observers (20 women, mean age 25 ± 5 y) rated 20 facial photographs with respect to fatigue, 10 facial cues, and sadness. The stimulus material consisted of 10 individuals (five women) photographed at 14:30 after normal sleep and after 31 h of sleep deprivation following a night with 5 h of sleep. Ratings of fatigue, fatigue-related cues, and sadness in facial photographs. The faces of sleep deprived individuals were perceived as having more hanging eyelids, redder eyes, more swollen eyes, darker circles under the eyes, paler skin, more wrinkles/fine lines, and more droopy corners of the mouth (effects ranging from b = +3 ± 1 to b = +15 ± 1 mm on 100-mm visual analog scales, P sleep deprivation (P sleep deprivation, nor associated with judgements of fatigue. In addition, sleep-deprived individuals looked sadder than after normal sleep, and sadness was related to looking fatigued (P sleep deprivation affects features relating to the eyes, mouth, and skin, and that these features function as cues of sleep loss to other people. Because these facial regions are important in the communication between humans, facial cues of sleep deprivation and fatigue may carry social consequences for the sleep deprived individual in everyday life.

Privatiseerimine ja erastamisväärtpaberite kontseptsioon Eestis / Alari Purju

Index Scriptorium Estoniae

Purju, Alari, 1953-

1994-01-01

Ülevaade erastamisväärtpaberite (EVP) kasutamisest, EVPde väljaandmise ja kasutamise alustest, EVPde ja erastatava vara bilansiga seotud probleemidest. EVPde kasutamise mõjust majanduse struktuurile, korterite, maa ja ettevõtete erastamise iseärasustest. Uurimus. Ilmunud ka inglise keeles: Working Papers nr. 82, Stockholm Institute of East European Economics, March 1994

Work on fusion technology at Studsvik during 1978

International Nuclear Information System (INIS)

Pauli, R.; Espefaelt, R.; Lorenzen, J.

1978-02-01

Studsvik is associated with the EUR-ATOM fusion research program and work within fusion technology is carried out regarding reactor control, conceptual design, safety and environmental impact; radiation damage. In addition research by subcontracts is done in atomic physics data at Lund university and in surface physics at Research Institute of Physics, Stockholm university. (author)

Publications | Page 88 | IDRC - International Development Research ...

International Development Research Centre (IDRC) Digital Library (Canada)

Results 871 - 880 of 6389 ... Good governance the key to counter risk, losses from climate change. Anton Cartwright of ACC and the Stockholm Environment Institute (SEI), spoke with writer José ... The weight of family networks plays a crucial role in learning ... and drought or low flows on fish cage culture in rivers in Thailand.

Job strain: a cross-sectional survey of dementia care specialists and other staff in Swedish home care services

Directory of Open Access Journals (Sweden)

Sandberg L

2018-05-01

Full Text Available Linda Sandberg,1 Lena Borell,1 David Edvardsson,2,3 Lena Rosenberg,1 Anne-Marie Boström1,4,5 1Department of Neurobiology, Care Sciences and Society (NVS, Division of Occupational Therapy, Karolinska Institutet, Huddinge, Sweden; 2School of Nursing and Midwifery, La Trobe University, Heidelberg, VIC, Australia; 3Department of Nursing, Umea University, Umea, Sweden; 4Theme Aging, Karolinska University Hospital, Stockholm, Sweden; 5Department of Nursing, Western Norway University of Applied Sciences, Haugesund, Norway Introduction: An increasing number of older persons worldwide live at home with various functional limitations such as dementia. So, home care staff meet older persons with extensive, complex needs. The staff’s well-being is crucial because it can affect the quality of their work, although literature on job strain among home care staff is limited. Aim: To describe perceived job strain among home care staff and to examine correlations between job strain, personal factors, and organizational factors. Methods: The study applied a cross-sectional survey design. Participants were dementia care specialists who work in home care (n=34 and other home care staff who are not specialized in dementia care (n=35. The Strain in Dementia Care Scale (SDCS and Creative Climate Questionnaire instruments and demographic variables were used. Descriptive and inferential statistics (including regression modeling were applied. The regional ethical review board approved the study. Results: Home care staff perceived job strain – particularly because they could not provide what they perceived to be necessary care. Dementia care specialists ranked job strain higher (m=5.71 than other staff members (m=4.71; p=0.04. Job strain (for total score and for all five SDCS factors correlated with being a dementia care specialist. Correlations also occurred between job strain for SDCS factor 2 (difficulties understanding and interpreting and not having Swedish as

Mapping of critical loads of acidity for the Italian terrestrial ecosystems; Mappa dei carichi critici di acidita' totale riferita al territorio italiano

Energy Technology Data Exchange (ETDEWEB)

Bonanni, P.; Brini, S.; Delmonaco, G.; Liburdi, C.; Trocciola, A.; Vetrella, G. [ENEA, Centro Ricerche Casaccia, Rome (Italy). Dipt. Ambiente

1999-07-01

In this report the mapping of critical loads of acidity for the Italian terrestrial ecosystems is presented. The level 0 method (Stockholm Environment Institute) has been used to determine sensitivity to acid deposition; this semi-quantitative method has been modified to address some Italian characteristics. The sensitivity of the Italian soils to acidification is not particularly elevated: there are really only few small areas with poor tolerance to acid depositions in the north-east Italy, Alpine and Prealpine region. [Italian] Nel presente relazione vengono riportati i risultati della mappatura riferita ad ecosistemi terrestri del territorio italiano, dei carichi critici per l'acidita' totale. Il calcolo dei carichi e' stato eseguito sulla base della metodologia messa a punto dallo Stockholm Environment Institute con alcune modifiche per adattarlo meglio alle caratteristiche del territorio italiano. Si dimostra che la sensibilita' dei suoli italiani all'acidificazione non sia particolarmente elevata: sono state riscontrate infatti solo alcune aree, peraltro con superficie limitata, con una scarsa tolleranza alle deposizioni acide nelle zone del Nord Est, in zona alpina e prealpina.

Karolinska Institutet 200-Year Anniversary. Symposium on Traumatic Injuries in the Nervous System: Injuries to the Spinal Cord and Peripheral Nervous System – Injuries and Repair, Pain Problems, Lesions to Brachial Plexus

Science.gov (United States)

Sköld, Mattias K.; Svensson, Mikael; Tsao, Jack; Hultgren, Thomas; Landegren, Thomas; Carlstedt, Thomas; Cullheim, Staffan

2011-01-01

The Karolinska Institutet 200-year anniversary symposium on injuries to the spinal cord and peripheral nervous system gathered expertise in the spinal cord, spinal nerve, and peripheral nerve injury field spanning from molecular prerequisites for nerve regeneration to clinical methods in nerve repair and rehabilitation. The topics presented at the meeting covered findings on adult neural stem cells that when transplanted to the hypoglossal nucleus in the rat could integrate with its host and promote neuron survival. Studies on vascularization after intraspinal replantation of ventral nerve roots and microarray studies in ventral root replantation as a tool for mapping of biological patterns typical for neuronal regeneration were discussed. Different immune molecules in neurons and glia and their very specific roles in synapse plasticity after injury were presented. Novel strategies in repair of injured peripheral nerves with ethyl-cyanoacrylate adhesive showed functional recovery comparable to that of conventional epineural sutures. Various aspects on surgical techniques which are available to improve function of the limb, once the nerve regeneration after brachial plexus lesions and repair has reached its limit were presented. Moreover, neurogenic pain after amputation and its treatment with mirror therapy were shown to be followed by dramatic decrease in phantom limb pain. Finally clinical experiences on surgical techniques to repair avulsed spinal nerve root and the motoric as well as sensoric regain of function were presented. PMID:21629875

Colorectal cancer in Crohn's disease--review of a 56-year experience in Karolinska Institute University Hospital.

Science.gov (United States)

Rubio, Carlos A; Befrits, Ragnar

2008-01-01

We previously reported that the frequency of colorectal carcinomas (CRC) in Crohn's disease (CD) had increased at this hospital between 1951 and May 1996. The aim was to compare the frequency of CRC in CD between June 1996 and September 2007 to that found between 1951 and May 1996. For that purpose colectomy specimens with an IBD-CRC diagnosis filed during the last 11 years were reviewed. It was found that 29 patients with IBD developed a CRC at this hospital: 21 had CD (or 1.91 cases/year) and the remaining eight, ulcerative colitis (or 0.72 cases/year). At this hospital, the number of cases of CRC in Crohn's colitis increased from 0.28/year between 1951 and the end of 1989, to 1.69 patients/year between 1990 and May 1996, and to 1.91 patients/year between June 1996 and September 2007 (present report). The marginal increase number of patients with CRC in Crohn's colitis/year during the last 11 years at this hospital might be only apparent, considering that the incidence of Crohn's disease in the county has dramatically increased, and that the localization of Crohn's disease has changed in later years, with a predilection for the colon and rectum.

Känslosvall från vindarnas land / Ann Lingebrandt

Index Scriptorium Estoniae

Lingebrandt, Ann

2008-01-01

Arvustus: Rooste, Jürgen. Presidenten bor nånstans i närheten / översättning: Peeter Puide. Stockholm : Ellerströms, 2007 ; fs. 2007 / översättning: Peeter Puide. Stockholm : Ellerströms, 2007 ; Kruusa, Kalju. Mötesvis / översättning: Peeter Puide. Stockholm : Ellerströms, 2007 ; Estniska ballader / översättning: Ilmar Laaban. Stockholm : Ellerströms, 2007 ; Laaban, Ilmar. Palingarderomb. Stockholm : Ellerströms, 2007 ; Under, Marie. Gnistor i askan / översättning: Enel Melberg. Stockholm : Ellerströms, 2007 ; Wuolijoki, Hella. Sõngen om kriget / översättning: Enel Melberg. Stockholm : Ellerströms, 2007 ; Alver, Betti. Historien om den vita krõkan / översättning: Enel Melberg. Stockholm : Ellerströms, 2007 ; Kaplinski, Jaan. Nõgonstans vid värlends kant / översättning: Juris Kronbergs och Guntar Godị̧. Tollarp : Ariel skrifter, 2007 ; Kareva, Doris. Tidens gestalt / översättning: Peeter Puide. Stockholm : Ellerströms, 2007

Mälu Instituut uurib inimõiguste rikkumisi

Index Scriptorium Estoniae

2008-01-01

President Toomas Hendrik Ilvese eestvedamisel asutati 20. sajandi teisel poolel Eestis toimunu põhjalikumaks uurimiseks Eesti Mälu Instituut. Ilmunud ka: Eesti Päevaleht (Stockholm) 14. veebr. 2008, lk. 2, pealk.: Mälu Instituut alustas tegevust; Vaba Eesti Sõna 7. veebr. 2008, lk. 12, pealk.: Under the leadership of President Ilves, the Memory Institute was established

Annual report 1976

International Nuclear Information System (INIS)

Nilsson, A.

1976-01-01

This annual report contains research reports from the various groups of the Research Institute of Physics, Stockholm. Reports are made by workers in the Atomic and Molecular Physics group, the Surface Physics group, the Nuclear Physics group, the group researching into High Energy Physics and related topics and the Instrumentation and Methods group. The report also contains a list of the papers published by members of the Institute during the year and a list of the theses which were presented. (B.D.)

Fluticasone propionate and increased risk of pneumonia in COPD: is it PAFR-dependent?

Directory of Open Access Journals (Sweden)

Sohal SS

2017-12-01

Full Text Available Sukhwinder Singh SohalDiscipline of Laboratory Medicine, School of Health Sciences, Faculty of Health, University of Tasmania, Launceston, AustraliaIt was with great interest that I read the recent comprehensive review by Christer Janson et al1 published in the International Journal of COPD, where authors discussed the possible mechanisms behind the increased risk of pneumonia in COPD patients using inhaled corticosteroids (ICSs, especially with fluticasone propionate (FP, where the risk was highest.1 It is an important area, and it is encouraging and reassuring that leading clinical journals are recognizing this. Understanding the fundamental mechanisms behind pneumococcal infections is critical.2 I would like to suggest that a broader discussion of new insights into the potential mechanisms contributing to the increased adherence of pneumococcus to airway wall and particularly in response to FP might has been appropriate with this opportunity.Authors’ replyChrister Janson,1 Georgios Stratelis,1,2 Anna Miller-Larsson,3 Tim W Harrison,4 Kjell Larsson51Respiratory, Allergy and Sleep Research Unit, Department of Medical Sciences, Uppsala University, Uppsala, 2Respiratory, Inflammation and Autoimmunity, AstraZeneca Nordic, Södertälje, 3Respiratory GMed, AstraZeneca Gothenburg, Mölndal, Sweden; 4Nottingham Respiratory Research Unit, City Hospital Campus, University of Nottingham, Nottingham, UK; 5Lung and Airway Research, National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, SwedenWe thank Dr Sohal for his interest in our recently published manuscript discussing the scientific rationale for the possible inhaled corticosteroid (ICS intraclass difference in the risk of pneumonia in COPD. His own work on platelet-activating factor receptor (PAFR expression on airway epithelial cells in COPD patients shows a trend toward increased expression of PAFR by 6-month treatment with fluticasone propionate (FP, suggesting an

Socio-economic analysis of the risk management of hexabromocyclododecane (HBCD) in China in the context of the Stockholm Convention.

Science.gov (United States)

Zhu, Jing; Liu, Jian-Guo; Hu, Jian-Xin; Yi, Shan

2016-05-01

Socio-economic analysis (SEA) plays an important role in decision-making on risk management actions for certain chemicals under Multilateral Environmental Agreements (MEAs) in developing countries. This paper showed the first holistic and quantitative SEA case study on that by developing a country-specific SEA framwork and methodologies and applying the case of HBCD phase-out in China under the Stockholm Convention on Persistent Organic Pollutants (POPs). The study indicates that, under the possible scenarios of 10 years and 5 years , the economic costs of HBCD phase-out in China would be between 9.032 and 19.021 billion RMB. Although the total economic costs seems to be significant, it would only have a marginal impact on the house building industry with a likely cost increase by about 0.07‰-0.14‰. Meanwhile, the HBCD phase-out may render significant environmental and health benefits, including about 23-29 tons of HBCD release prevented to the environment, 1.142-1.469 million tons of potentially HBCD contained hazardous wastes avoided, along with significant reduction from 58% up to almost 100% in local environmental concentrations of HBCD, and about 0.0996-0.128 million workers at risk avoided and at least 3.067-4.033 billion RMB of the health care savings. While the scenario of phasing out HBCD over 10 years would be less costly than the scenario of that over 5 years, the later scenario suggested much greater environmental and health benefits for China. Copyright © 2015 Elsevier Ltd. All rights reserved.

Differences in structure of adventitious roots in Salix clones with contrasting characteristics of cadmium accumulation and sensitivity

Czech Academy of Sciences Publication Activity Database

Lux, A.; Šottníková, A.; Opatrná, Jana; Greger, M.

2004-01-01

Roč. 120, č. 4 (2004), s. 537-545 ISSN 0031-9317 R&D Projects: GA AV ČR KSK5020115 Grant - others:Slovak Grant Agency(SK) 1/0100/03; Stockholm University(SE) COST Action 837 Institutional research plan: CEZ:AV0Z5038910 Keywords : PLANT-MATERIAL * TOLERANCE * BARRIERS Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 2.017, year: 2004

A perspective on the U.S. economic outlook and monetary policy

OpenAIRE

Charles I. Plosser

2013-01-01

Presented by Charles I. Plosser, President and Chief Executive Officer, Federal Reserve Bank of Philadelphia, Global Interdependence Center's Central Banking Series: Recovery 2013 — Strength or Stagnation?, Milan, Italy, May 16, 2013 ; Note: President Plosser presented similar remarks on May 14, 2013, before the SNS (Center for Business and Policy Studies) and the SIFR (The Institute for Financial Research) in Stockholm, Sweden.

High sensitivity hydrogen sensors based on GaN

Czech Academy of Sciences Publication Activity Database

Yatskiv, Roman; Grym, Jan; Žďánský, Karel

2012-01-01

Roč. 7, č. 9 (2012), s. 1661-1663 ISSN 1610-1642. [16th International Semiconducting and Insulating Materials Conference (SIMC-XVI). Stockholm, 19.06.2011-23.06.2011] R&D Projects: GA MŠk(CZ) OC10021 Institutional support: RVO:67985882 Keywords : Pt nanoparticles * Graphite based Schottky diodes * Hydrogen sensor * GaN Subject RIV: JA - Electronics ; Optoelectronics, Electrical Engineering

The influence of personality, measured by the Karolinska Scales of Personality (KSP), on symptoms among subjects in suspected sick buildings.

Science.gov (United States)

Runeson, R; Norbäck, D; Klinteberg, B; Edling, C

2004-12-01

The aim was to study possible relationships between personality traits as measured by the Karolinska Scales of Personality (KSP), a self-report personality inventory based on psychobiological theory, and medical symptoms, in subjects with previous work history in suspected sick buildings. The study comprised 195 participants from 19 consecutive cases of suspected sick buildings, initially collected in 1988-92. In 1998-89, the KSP inventory and a symptoms questionnaire were administered in a postal follow-up study. There were 16 questions on symptoms, including symptoms from the eyes, nose, throat, skin, and headache, tiredness, and a symptom score (SC), ranging from 0 to 16, was calculated. The questionnaire also requested information on personal factors, including age, gender, smoking habits, allergy and diagnosed asthma. The KSP ratings in the study group did not differ from the mean personality scale norm scores, calculated from an external reference group. Females had higher scores for somatic anxiety (P < 0.01), muscular tension (P < 0.001), psychic anxiety (P < 0.01), psychasthenia (P < 0.05), indirect aggression (P < 0.05), and guilt (P < 0.05), while males scored higher on detachment (P < 0.001). Subjects with higher SC were found to display higher degree of somatic anxiety (P < 0.001), muscular tension (P < 0.001), psychic anxiety (P < 0.001), psychasthenia (P < 0.001), inhibition of aggression (P < 0.05), detachment (P < 0.05), suspicion (P < 0.01), indirect aggression (P < 0.01), and verbal aggression (P < 0.05). In addition, ocular, respiratory, dermal, and systemic symptoms (headache and tiredness) were significantly related to anxiety- and aggressivity-related scales. There were associations between personality scales and change of symptom score (SC) during the 9-year period. The associations between KSP personality traits and symptoms were more pronounced in females. In conclusion, there are gender differences in personality and SBS symptoms

Astrid-2 EMMA Magnetic Calibration

DEFF Research Database (Denmark)

Merayo, José M.G.; Brauer, Peter; Risbo, Torben

1998-01-01

The Swedish micro-satellite Astrid-2 contains a tri-axial fluxgate magnetometer with the sensor co-located with a Technical University of Denmark (DTU) star camera for absolute attitude, and extended about 0.9 m on a hinged boom. The magnetometer is part of the RIT EMMA electric and magnetic fields...... experiment built as a collaboration between the DTU, Department of Automation and the Department of Plasma Physics, The Alfvenlaboratory, Royal Institute of Technology (RIT), Stockholm. The final magnetic calibration of the Astrid-2 satellite was done at the Lovoe Magnetic Observatory under the Geological...... Survey of Sweden near Stockholm on the night of May 15.-16., 1997. The magnetic calibration and the intercalibration between the star camera and the magnetic sensor was performed by measuring the Earth's magnetic field and simultaneously observing the star sky with the camera. The rotation matrix between...

4th international conference in sustainability in energy and buildings

CERN Document Server

Höjer, Mattias; Howlett, Robert; Jain, Lakhmi

2013-01-01

This volume contains the proceedings of the Fourth International Conference on Sustainability in Energy and Buildings, SEB12, held in Stockholm, Sweden, and is organised by KTH Royal Institute of Technology, Stockholm, Sweden in partnership with KES International. The International Conference on Sustainability in Energy and Buildings focuses on a broad range of topics relating to sustainability in buildings but also encompassing energy sustainability more widely. Following the success of earlier events in the series, the 2012 conference includes the themes Sustainability, Energy, and Buildings and Information and Communication Technology, ICT. The SEB’12 proceedings includes invited participation and paper submissions across a broad range of renewable energy and sustainability-related topics relevant to the main theme of Sustainability in Energy and Buildings. Applicable areas include technology for renewable energy and sustainability in the built environment, optimisation and modeling techniques, informati...

Approaches to Identification of Institutions in Institutional Economics

Directory of Open Access Journals (Sweden)

Igor M. Shiriaev

2017-03-01

Full Text Available The paper deals with the methodology for identification of institutions from institutional economics perspective. The differences between the perspectives provided by old and new institutional economics are highlighted. These differences are interpreted in the context of compared pragmatist and postpositivist methodologies. This paper applies to the post-positivist approach to the identification of institutions. One example of institution is provided by power-property institution. Identification of this institution in the historical and economic research is based on several theoretical generalizations and supported by array of historical facts. Another example is provided by identification of institution and institutional change in higher education based on discourse analysis and interviews with the main actors. In this paper, the regulatory institutions of higher education are analyzed as well. The concept of power-property institution is extended to the higher education by proposing hypotheses on the functioning of state governing-regulating institution in this sphere. This institution prescribes the actors to behave in accordance with the objectives of public policy, which can only be implemented in the form of bureaucratization of higher education. The paper describes the behavioral regularity generated by an identified institution. Functioning of the governing-regulating institution in higher education is illustrated by examples of behavioral regularities emerging from activities in accordance with this institution. The paper also shows the possibility of falsification of proposed hypothesis.

In Memoriam: Professor Jan M. Hoem

Directory of Open Access Journals (Sweden)

James W. Vaupel

2017-02-01

Full Text Available Jan Hoem died on Saturday in Stockholm after a long illness. Jan became Director of the Max Planck Institute for Demographic Research (MPIDR in 1999; he and I jointly led the Institute for almost eight years. During this period he served as Editor of Demographic Research; he took on this responsibility shortly after the journal was launched and built the journal into a respected online source of cutting-edge analysis. Jan was a superb colleague, with very good judgment, a delightful sense of humor, and deep devotion to research quality. A pioneer of event history analysis, he understood the subtleties of the subject better than anyone else. Jan was born and educated in Norway and worked in Oslo before becoming Professor in Copenhagen and then Professor in Stockholm, where he established SUDA, a leading demographic research initiative. His dedication to high-quality, statistically sophisticated population research at SUDA and MPIDR as well as in the journal Demographic Research substantially advanced the discipline of demography. Jan was a warm and generous teacher, a loyal colleague, and a caring friend whom many people will long remember with gratitude and respect. James W. Vaupel Publisher, Demographic Research

SIPRI's new conceptual approach to arms control and disarmament

International Nuclear Information System (INIS)

Rotfeld, Adam Daniel

2000-01-01

The end of the cold war deprioritized arms control and disarmament, and progress in the field was no longer a measure of relations among the major powers. In that context, the future of arms control and disarmament was discussed at the Nobel Symposium in October 1999. Stockholm International Peace Research Institute (SIPRI) views arms control as an instrument for shaping a new inclusive and cooperative security order. The author questions whether arms control challenges today can and should be resolved in the institutions established and the procedures elaborated in the bipolar framework. (author)

Scale issues in the assessment of ecological impacts using a GIS-based habitat model - A case study for the Stockholm region

International Nuclear Information System (INIS)

Gontier, Mikael

2007-01-01

Environmental Impact Assessment (EIA) and Strategic Environmental Assessment (SEA) provide two interlinked platforms for the assessment of impacts on biodiversity caused by human developments. Although it might be too early to draw conclusions on the efficiency of SEA to assess such impacts, a number of persistent problems have been identified in the case of EIA. Some of these shortcomings concern the lack of proper prediction and impact quantification, and the inadequate/insufficient assessment of cumulative effects. A number of problems are related to the scale(s) at which the assessment is performed. SEA may provide a more adequate framework than EIA to discuss scale-related issues (i.e. cumulative impacts) but it also requires the use of adapted tools. This paper presents a case study where a GIS-based habitat model for the lesser spotted woodpecker is tested, validated and applied to a planning scenario in the Stockholm region in Sweden. The results show that the method adopted offers great prospects to contribute to a better assessment of biodiversity-related impacts. Even though some limitations remain in the form of data requirement and interpretation of the results, the model produced continuous, quantified predictions over the study area and provided a relevant basis for the assessment of cumulative effects. Furthermore, this paper discusses potential conflicts between different scales involved in the assessment - related to administrative boundaries, ecological processes, data availability, the method adopted to perform the assessment and temporal aspects

Review of National Work Programme on the Long Term Effects of Sustained High G on the Cervical Spine (Analyse du programme de travail national : les effets long terme sur la colonne cervicale d’un nombre de G lev et prolong )

Science.gov (United States)

2008-12-01

Neck Muscle 6-7 Function and Symptoms of Neck Pain in UK Student Pilots 6.3.3 Other Ongoing Relevant Activities 6-9 6.4 Unclassified Reports...Prof. Karin Harms-Ringdahl, PhD, RPT Karolinska Institutet Department of Neurobiology, Care Sciences, and Society Division of Physiotherapy 23100...Äng Karolinska Institutet Department of Neurobiology, Care Sciences, and Society Division of Physiotherapy Alfred Nobels Allé 23100 SE-14183

Uppföljning av logopedisk behandling för patienter med träningsinducerad vocal cord dysfunction

OpenAIRE

Hamberg, Lena; Karlsson, Sanna

2014-01-01

Abstract. Several treatment options are described for patients with vocal cord dysfunction. At Karolinska University hospital, these patients are offered treatment by speech and language pathologists. The current study describes traits and treatment effects for 148 people diagnosed with exercise-induced vocal cord dysfunction at Karolinska University hospital who received treatment by speech and language pathologists in 2005-2012. Data were collected from medical records and through a questi...

How institutions matter for international business : Institutional distance effects vs institutional profile effects

NARCIS (Netherlands)

van Hoorn, Andre; Maseland, Robbert

Extant institutional research has failed to make a distinction between the effects of institutional profile and institutional distance on MNEs. The problem stems from the fact that, due to the use of a single reference country, variation in institutional distance between the reference country and

Konference VALDOR a projekt ARGONA

Czech Academy of Sciences Publication Activity Database

Vajdová, Zdenka

2009-01-01

Roč. 45, č. 5 (2009), s. 1144-1147 ISSN 0038-0288. [Values in Decisions On Risk. Stockholm, 08.06.2009-11.06.2009] R&D Projects: GA MŠk 2D06006; GA MŠk 2D06001 Institutional research plan: CEZ:AV0Z70280505 Keywords : risk management * nuclear waste sitting * risk communication Subject RIV: AO - Sociology, Demography Impact factor: 0.562, year: 2009

Cyber Defense: An International View

Science.gov (United States)

2015-09-01

and Mathematics at the Royal Institute of Tech- nology, Stockholm, Sweden; and Otto von Guericke University, Magdeburg , Germany . viii ix SUMMARY...and analysis to influence policy debate and bridge the gap between military and academia. The Center for Strategic Leadership and Development...provide an overview of four different national approaches to cyber defense: those of Nor- way, Estonia, Germany , and Sweden. While provid- ing a

The National Resource Library for Science and Technology in Sweden: A Nordic model of cooperating technology libraries

Science.gov (United States)

Lagar, Gunnar

1994-01-01

The scope of this presentation is to give a state-of-the-art report on the present situation of Nordic technology libraries, to elaborate on a plan for national resource libraries in Sweden, and to share how the Royal Institute of Technology Library in Stockholm (KTHB) has fostered a network of cooperating libraries in order to optimize government funding for the system of resource libraries.

Plant Poisonings According to the Czech Toxicological Information Centre from 2005 to 2008

Czech Academy of Sciences Publication Activity Database

Říčařová, B.; Rakovcová, H.; Pelclová, D.; Navrátil, Tomáš

2009-01-01

Roč. 47, č. 5 (2009), s. 473-473 ISSN 1556-3650. [The International Congress of the European Association of Poison Centres and Clinical Toxicologists /29./. 12.05.2009-15.05.2009, Stockholm] R&D Projects: GA AV ČR IAA400400806 Institutional research plan: CEZ:AV0Z40400503 Keywords : Czech Toxicological Information Centre * plant poison ings according Subject RIV: CF - Physical ; Theoretical Chemistry

Dose-response relations for stricture in the proximal oesophagus from head and neck radiotherapy

International Nuclear Information System (INIS)

Alevronta, Eleftheria; Ahlberg, Alexander; Mavroidis, Panayiotis; Al-Abany, Massoud; Friesland, Signe; Tilikidis, Aris; Laurell, Goeran; Lind, Bengt K.

2010-01-01

Background and purpose: Determination of the dose-response relations for oesophageal stricture after radiotherapy of the head and neck. Material and methods: In this study 33 patients who developed oesophageal stricture and 39 patients as controls are included. The patients received radiation therapy for head and neck cancer at Karolinska University Hospital, Stockholm, Sweden. For each patient the 3D dose distribution delivered to the upper 5 cm of the oesophagus was analysed. The analysis was conducted for two periods, 1992-2000 and 2001-2005, due to the different irradiation techniques used. The fitting has been done using the relative seriality model. Results: For the treatment period 1992-2005, the mean doses were 49.8 and 33.4 Gy, respectively, for the cases and the controls. For the period 1992-2000, the mean doses for the cases and the controls were 49.9 and 45.9 Gy and for the period 2001-2005 were 49.8 and 21.4 Gy. For the period 2001-2005 the best estimates of the dose-response parameters are D 50 = 61.5 Gy (52.9-84.9 Gy), γ = 1.4 (0.8-2.6) and s = 0.1 (0.01-0.3). Conclusions: Radiation-induced strictures were found to have a dose response relation and volume dependence (low relative seriality) for the treatment period 2001-2005. However, no dose response relation was found for the complete material.

Genetic factors may play a prominent role in the development of coronary heart disease dependent on important environmental factors

Science.gov (United States)

Song, C; Chang, Z; Magnusson, P K E; Ingelsson, E; Pedersen, N L

2014-01-01

Astract Song C, Chang Z, Magnusson PKE, Ingelsson E, Pedersen NL (Karolinska Institutet, Stockholm; Uppsala University, Uppsala; Sweden). Genetic factors may play a prominent role in the developmentofcoronary heart diseasedependenton important environmental factors. J InternMed2014; 275: 631–639. Objective The aim of the study was to examine whether various lifestyle factors modify genetic influences on coronary heart disease (CHD). Design The effect of lifestyle factors [including smoking, sedentary lifestyle, alcohol intake and body mass index (BMI)] on risk of CHD was evaluated via Cox regression models in a twin study of gene–environment interaction. Using structure equation modelling, we estimated genetic variance of CHD dependent on lifestyle factors. Subjects In total, 51 065 same-sex twins from 25 715 twin pairs born before 1958 and registered in the Swedish Twin Registry were eligible for this study. During the 40-year follow-up, 7264 incident CHD events were recorded. Results Smoking, sedentary lifestyle and above average BMI were significantly associated with increased CHD incidence. The heritability of CHD decreased with increasing age, as well as with increasing levels of BMI, in both men and women. Conclusions The difference in the genetic component of CHD as a function of BMI suggests that genetic factors may play a more prominent role for disease development in the absence of important environmental factors. Increased knowledge of gene–environment interactions will be important for a full understanding of the aetiology of CHD. PMID:24330166

In vitro differentiation of rat spermatogonia into round spermatids in tissue culture.

Science.gov (United States)

Reda, A; Hou, M; Winton, T R; Chapin, R E; Söder, O; Stukenborg, J-B

2016-09-01

vitro or testosterone production was observed. The human testis is very different in physiology from the rat testis, further investigations are still needed to optimize the organ culture system for future use in humans. The successful differentiation of undifferentiated spermatogonia using the testis explant culture system might be employed in future to produce sperm from human spermatogonia as a clinical tool for fertility preservation in boys and men suffering infertility. None. This work was supported financially by the Frimurare Barnhuset in Stockholm, the Paediatric Research Foundation, Jeanssons Foundation, Sällskåpet Barnåvard in Stockholm, Swedish Research Council/Academy of Finland, Emil and Wera Cornells Foundation, Samariten Foundation, the Swedish Childhood Cancer Foundation as well as through the regional agreement on medical training and clinical research (ALF) between Stockholm County Council and Karolinska Institutet. All authors declare no conflicts of interests. © The Author 2016. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology.

Stockholm '98

Index Scriptorium Estoniae

1998-01-01

Live Music for Vibrant Dance-etendused 17.-23. aug. Rootsi balletikoolis, The Bomb Party - muusikaline etendus Göteborgi Ooperilt 18.-20. aug. Folkoperas ja Euroopa Liidu Noorteorkestri kontserdid 18., 22. aug

Stockholm: Results

International Nuclear Information System (INIS)

1972-01-01

The United Nations Conference on the Human Environment accepted by acclamation - although with some reservations - a declaration on the Human Environment, and recommended for approval by the General Assembly of the United Nations an action plan and the establishment of a 54-member Governing Council for Environmental Programmes, which would report annually to the General Assembly through the Economic and Social Council. It further recommended that a small secretariat be established, to be headed by an Executive Director to be elected by the General Assembly on the nomination of the Secretary-General. (author)

Gade: Symphonies. Copenhagen Collegium Musicum / Robert Layton

Index Scriptorium Estoniae

Layton, Robert

1994-01-01

Uuest heliplaadist "Gade: Symphonies. Copenhagen Collegium Musicum. Michael Schonwandt.Marco Polo Dacapo CD DCCD 9201/2; Comparative versions: Symphony No. 1. Stockholm Sinf. / Järvi (11/87) BIS CD 339; Symphony No. 2.Stockholm Sinf. / Järvi (12/87) BIS CD 355; Symphony No. 4. Stockholm Sinf. / Järvi" (7/87) BIS CD 338; Symphony No. 6. Stockholm Sinf. / Järvi (12/87) BIS CD 356

System analysis of energy utilization from waste - evaluation of energy, environment and economy. Case study - Stockholm

International Nuclear Information System (INIS)

Sundqvist, Jan-Olov; Granath, Jessica; Frostell, Bjoern; Bjoerklund, Anna; Eriksson, Ola; Carlsson, Marcus

1999-12-01

Energy, environmental, and economic consequences of different management systems for municipal solid waste have been studied in a systems analysis. In the systems analysis, different combinations of incineration, materials recycling of separated plastic and cardboard containers, and biological treatment (anaerobic digestion) of easily degradable organic waste, were studied and also compared to landfilling. In the study a computer model (ORWARE) based on LCA methodology was used. The following parameters were used for evaluating the different waste management options: consumption of energy resources, global warming potential, acidification, eutrophication, photo oxidant formation, heavy metal flows, financial economy and welfare economy, where welfare economy is the sum of financial economy and environmental economy. The study shows that reduced landfilling to the benefit of an increased use of energy and material from the waste is positive, from an environmental and energy as well as economic aspect. This is mainly due to the fact that the choice of waste management method affects processes outside the waste management system, such as production of district heating, electricity, vehicle fuel, plastic, cardboard, and fertiliser. This means that landfilling of energy-rich waste should be avoided as far as possible, both because of the the environmental impact, and because of the low recovery of resources. Incineration should constitute a basis in the waste management system of Stockholm. Once the waste is collected, longer regional transports are of little significance, as long as the transports are carried out in an efficient manner. Comparing materials recycling and incineration, and biological treatment and incineration, no unambiguous conclusions can be drawn. There are benefits and drawbacks associated with all these waste management options. Materials recycling of plastic containers is comparable to incineration from a welfare economic aspect, but gives less

Correlation between lamivudine plasma concentrations and patient self-reported adherence to antiretroviral treatment in experienced HIV patients

Directory of Open Access Journals (Sweden)

Minzi OM

2011-11-01

Full Text Available OM Minzi1, V Mugoyela2, LL Gustafsson31Unit of Pharmacology and Therapeutics, 2Department of Medicinal Chemistry, School of Pharmacy, Muhimbili University of Health and Allied Sciences, Dar Es Salaam, Tanzania; 3Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, SwedenBackground: Adherence to antiretroviral treatment (ART is important to achieve treatment success in human immunodeficiency virus (HIV-infected patients. Most HIV clinics apply the patient self-report (PSR method. However, the reliability of this method in experienced HIV patients remains questionable.Purpose: To validate the PSR method for measuring adherence to ART using lamivudine (3TC plasma concentrations in experienced HIV patients.Methods: The study was conducted in Dar Es Salaam and involved 220 patients who were receiving ART services at HIV clinics for more than 12 months. Self-reported adherence information to ART was obtained on the day of HIV clinic visit. The patients were asked to mention the number of doses missed within the past 7 days. In addition, blood samples (2 mL were collected from each patient on the same day. The blood samples were determined for 3TC plasma concentrations. The target 3TC plasma concentration as indicator concentration for adherent patients was determined in 20 patients who took their evening dose of antiretrovirals under supervision. The blood from these patients was drawn 3 hours after drug administration.Results: Complete drug levels of 3TC and self-reported adherence data was obtained in 200 treatment-experienced HIV patients. Lamivudine plasma concentrations obtained in these patients ranged between 0.02–17.36 µg/mL. The mean time from dose administration to blood drawing was 3.1 ± 1.2 hours with coefficient of variation >39%. The mean 3TC plasma concentration obtained in 20 patients who took their antiretroviral dose under supervision was

Enterprise Architecture Modeling of Core Administrative Systems at KTH : A Modifiability Analysis

OpenAIRE

Rosell, Peter

2012-01-01

This project presents a case study of modifiability analysis on the Information Systems which are central to the core business processes of Royal Institution of Technology in Stockholm, Sweden by creating, updating and using models. The case study was limited to modifiability regarding only specified Information Systems. The method selected was Enterprise Architecture together with Enterprise Architecture Analysis research results and tools from the Industrial Information and Control Systems ...

sSWOT-analysis of the introduction and usage of faecal sludge as fertiliser in agriculture in the Western Cape Province, South Africa

OpenAIRE

Frise, Felicia; Ringström, Anna

2017-01-01

For future generations, securing nutrients and minimising the biochemical flows are significant challenges for humanity. Due to this, it is important to develop new phosphorous recovery methods from alternative sources to secure food production, reach sustainable development and circular economy. Secondary resources, such as sewage sludge, could compensate for the future limited supply of phosphate rocks. This essay, done by two students from KTH Royal Institute of Technology, Stockholm, Swed...

Absenteeism and sex differences in attitudes in Dutch health care and welfare institutions : paper presented at the VIIth European conference on Organisational Psychology and Health Care, Stockholm, 11-13 October 2001

NARCIS (Netherlands)

Vuuren, C.V. van; Gent, M.J. van; Smit, A.A.

2001-01-01

In Dutch health care and welfare institutions 75% of the employees are women. On the whole, women are more frequently absent because of illness than men. In the Dutch health care and welfare sector workplace absenteeism is in fact higher than the national average: in 1997 the national average was

Evolutionary institutionalism.

Science.gov (United States)

Fürstenberg, Dr Kai

Institutions are hard to define and hard to study. Long prominent in political science have been two theories: Rational Choice Institutionalism (RCI) and Historical Institutionalism (HI). Arising from the life sciences is now a third: Evolutionary Institutionalism (EI). Comparative strengths and weaknesses of these three theories warrant review, and the value-to-be-added by expanding the third beyond Darwinian evolutionary theory deserves consideration. Should evolutionary institutionalism expand to accommodate new understanding in ecology, such as might apply to the emergence of stability, and in genetics, such as might apply to political behavior? Core arguments are reviewed for each theory with more detailed exposition of the third, EI. Particular attention is paid to EI's gene-institution analogy; to variation, selection, and retention of institutional traits; to endogeneity and exogeneity; to agency and structure; and to ecosystem effects, institutional stability, and empirical limitations in behavioral genetics. RCI, HI, and EI are distinct but complementary. Institutional change, while amenable to rational-choice analysis and, retrospectively, to criticaljuncture and path-dependency analysis, is also, and importantly, ecological. Stability, like change, is an emergent property of institutions, which tend to stabilize after change in a manner analogous to allopatric speciation. EI is more than metaphorically biological in that institutional behaviors are driven by human behaviors whose evolution long preceded the appearance of institutions themselves.

Insights into the mechanisms of vertical transmission of HIV-1. BIOMED2 Working Group on the in utero transmission of HIV-1.

Science.gov (United States)

Menu, E; Mognetti, B; Moussa, M; Nardese, V; Tresoldi, L; Tscherning, C; Mbopi Keou, F X; Dubanchet, S; Mauclere, P; Fenyö, E M; Scarlatti, G; Barre-Sinoussi, F; Chaouat, G

1997-12-01

This paper is a summary of three oral presentations, as well as the ensuing discussion, at the Rijeka/Opatija 3rd Alps Adria Immunology meeting by three members of the European Biomed group on vertical transmission of HIV (G. Chaouat, F. Barre-Sinoussi, G. Scarlatti). This group also involves the laboratories of D. Dormont (CEA, Fontenay aux roses, France), P. Gounon (Electron Microscopy, the Pasteur Institute, France; Irène Athanassakis, University of Crete, Greece; Eva Maria Fenyö, Karolinska Institute, Sweden; and Larry Guilbert, Canada). As such, this paper intends to be neither a review, nor an original article, but rather is an opinion paper discussing the working hypothesis of this network, as well as some of their recent results, which were presented at this meeting. The paper was issued at the request of the organizers of the meeting.

Association between a promoter dopamine D2 receptor gene variant and the personality trait detachment.

Science.gov (United States)

Jönsson, Erik G; Cichon, Sven; Gustavsson, J Petter; Grünhage, Frank; Forslund, Kaj; Mattila-Evenden, Marja; Rylander, Gunnar; Asberg, Marie; Farde, Lars; Propping, Peter; Nöthen, Markus M

2003-04-01

Personality traits have shown considerable heritable components. Striatal dopamine D(2) receptor density, as determined by positron-emission tomography, has been associated with detached personality, as assessed by the Karolinska Scales of Personality. A putative functional promoter polymorphism in the dopamine D(2) receptor gene (DRD2), -141C ins/del, has been associated with dopamine D(2) receptor density. In this study healthy subjects (n = 235) who filled in at least one of several personality questionnaires (Karolinska Scales of Personality, Swedish Universities Scales of Personality, Health-relevant Five-factor Personality Inventory, and Temperament and Character Inventory) were analyzed with regard to the DRD2 -141C ins/del variant. There was an association (p =.001) between the DRD2 -141C ins/del variant and Karolinska Scales of Personality Detachment scale, indicating higher scores in subjects with the -141C del variant. There were also associations between the DRD2 -141C ins/del variant and a number of Karolinska Scales of Personality and Swedish Universities Scales of Personality Neuroticism-related scales, but of these only Swedish Universities Scales of Personality Lack of Assertiveness scale (p =.001) survived correction for multiple testing. These results add further support for the involvement of dopamine D(2) receptor in certain personality traits. The results should be treated with caution until replicated.

Institutional entrepreneurship:

DEFF Research Database (Denmark)

Gretzinger, Susanne

2018-01-01

Institutional entrepreneurship pays specific attention to the process and outcomes of agents who are willing and capable of changing institutions. It has some common ground with the political entrepreneur, a concept that proposes change in norms and institutions because of commitment and activities...... of agents or organisations in the policy arena. The present chapter understands institutional entrepreneurship as the process of changing institutionalised practices. Based on a literature review, it describes the triggers, activities and potential effects of institutional entrepreneurs. The chapter...... concludes by tentatively arguing that political entrepreneurs can be institutional entrepreneurs, but institutional entrepreneurship can be considered as the broader concept that incorporates strategies and visions as well as interpretative-discursive power into the conceptual framework....

Engineering Institute

Science.gov (United States)

Projects Past Projects Publications NSEC » Engineering Institute Engineering Institute Multidisciplinary engineering research that integrates advanced modeling and simulations, novel sensing systems and new home of Engineering Institute Contact Institute Director Charles Farrar (505) 665-0860 Email UCSD EI

Implementation of environmental management in China

OpenAIRE

Håkansson, Susanna

2005-01-01

This thesis project was carried out within the cooperation between theIndustrial Ecology Department at Royal Institute of Technology (KTH),Stockholm, Sweden and Center for Space Thermal Science of ShandongUniversity, Jinan, China. The aim of this thesis report is to investigate Environmental ManagementSystem (EMS) and its support system, give a general view of theenvironmental work in companies in China, and make recommendation forSwedish joint ventures how they should work with environmental...

The 'wise list'- a comprehensive concept to select, communicate and achieve adherence to recommendations of essential drugs in ambulatory care in Stockholm.

Science.gov (United States)

Gustafsson, Lars L; Wettermark, Björn; Godman, Brian; Andersén-Karlsson, Eva; Bergman, Ulf; Hasselström, Jan; Hensjö, Lars-Olof; Hjemdahl, Paul; Jägre, Ingrid; Julander, Margaretha; Ringertz, Bo; Schmidt, Daniel; Sjöberg, Susan; Sjöqvist, Folke; Stiller, Carl-Olav; Törnqvist, Elisabeth; Tryselius, Rolf; Vitols, Sigurd; von Bahr, Christer

2011-04-01

The aim was to present and evaluate the impact of a comprehensive strategy over 10 years to select, communicate and achieve adherence to essential drug recommendations (EDR) in ambulatory care in a metropolitan healthcare region. EDRs were issued and launched as a 'Wise List' by the regional Drug and Therapeutics Committee in Stockholm. This study presents the concept by: (i) documenting the process for selecting, communicating and monitoring the impact of the 'Wise List'; (ii) analysing the variation in the number of drug substances recommended between 2000 and 2010; (iii) assessing the attitudes to the 'Wise List' among prescribers and the public; (iv) evaluating the adherence to recommendations between 2003 and 2009. The 'Wise List' consistently contained 200 drug substances for treating common diseases. The drugs were selected based on their efficacy, safety, suitability and cost-effectiveness. The 'Wise List' was known among one-third of a surveyed sample of the public in 2002 after initial marketing campaigns. All surveyed prescribers knew about the concept and 81% found the recommendations trustworthy in 2005. Adherence to recommendations increased from 69% in 1999 to 77% in 2009. In primary care, adherence increased from 83% to 87% from 2003 to 2009. The coefficient of variation (CV%) decreased from 6.1% to 3.8% for 156 healthcare centres between these years. The acceptance of the 'Wise List' in terms of trust among physicians and among the public and increased adherence may be explained by clear criteria for drug recommendations, a comprehensive communication strategy, electronic access to recommendations, continuous medical education and involvement of professional networks and patients.

Anabolic Androgenic Steroids—Use and Correlates among Gym Users—An Assessment Study Using Questionnaires and Observations at Gyms in the Stockholm Region

Directory of Open Access Journals (Sweden)

Charlotta Rehnman

2011-06-01

Full Text Available The purpose of this study was to estimate the prevalence of anabolic androgenic steroid (AAS use and offers to use among gym users in Stockholm County (Sweden, and to conduct a comparison of concordance in estimates of AAS and supplements at gyms between two data collection methods. A questionnaire was distributed to members at 36 training facilities and 1,752 gym users participated in the study. An observation study was conducted as covert participant observations at 64 gyms. According to the questionnaire, 3.9% of men reported life time use of AAS, 1.4% use during the past 12 months and 0.4% AAS use during past 30 days. Not only were there similar patterns found in the two methods, i.e., similar age and gender distributions for AAS use, but analyses of concordance showed that gyms with a higher prevalence of self-reported AAS-use and supplement use (questionnaire showed a significantly higher proportion of observer-assessed AAS users. Analyses of individual predictors showed that AAS users were almost always young men, regular weight trainers and more often users of drugs and nutritional supplements. The higher prevalence of AAS use among gym users than in the general population makes the former an appropriate target group for AAS prevention. The connection between supplements, drugs and AAS use suggests that effective AAS prevention need to focus on several risk factors for AAS use. The clear resemblance in estimates between the observation and questionnaire data strengthen the credibility of the two methods.

Anabolic Androgenic Steroids—Use and Correlates among Gym Users—An Assessment Study Using Questionnaires and Observations at Gyms in the Stockholm Region

Science.gov (United States)

Leifman, Håkan; Rehnman, Charlotta; Sjöblom, Erika; Holgersson, Stefan

2011-01-01

The purpose of this study was to estimate the prevalence of anabolic androgenic steroid (AAS) use and offers to use among gym users in Stockholm County (Sweden), and to conduct a comparison of concordance in estimates of AAS and supplements at gyms between two data collection methods. A questionnaire was distributed to members at 36 training facilities and 1,752 gym users participated in the study. An observation study was conducted as covert participant observations at 64 gyms. According to the questionnaire, 3.9% of men reported life time use of AAS, 1.4% use during the past 12 months and 0.4% AAS use during past 30 days. Not only were there similar patterns found in the two methods, i.e., similar age and gender distributions for AAS use, but analyses of concordance showed that gyms with a higher prevalence of self-reported AAS-use and supplement use (questionnaire) showed a significantly higher proportion of observer-assessed AAS users. Analyses of individual predictors showed that AAS users were almost always young men, regular weight trainers and more often users of drugs and nutritional supplements. The higher prevalence of AAS use among gym users than in the general population makes the former an appropriate target group for AAS prevention. The connection between supplements, drugs and AAS use suggests that effective AAS prevention need to focus on several risk factors for AAS use. The clear resemblance in estimates between the observation and questionnaire data strengthen the credibility of the two methods. PMID:21845151

Anabolic androgenic steroids--use and correlates among gym users--an assessment study using questionnaires and observations at gyms in the Stockholm region.

Science.gov (United States)

Leifman, Håkan; Rehnman, Charlotta; Sjöblom, Erika; Holgersson, Stefan

2011-07-01

The purpose of this study was to estimate the prevalence of anabolic androgenic steroid (AAS) use and offers to use among gym users in Stockholm County (Sweden), and to conduct a comparison of concordance in estimates of AAS and supplements at gyms between two data collection methods. A questionnaire was distributed to members at 36 training facilities and 1,752 gym users participated in the study. An observation study was conducted as covert participant observations at 64 gyms. According to the questionnaire, 3.9% of men reported life time use of AAS, 1.4% use during the past 12 months and 0.4% AAS use during past 30 days. Not only were there similar patterns found in the two methods, i.e., similar age and gender distributions for AAS use, but analyses of concordance showed that gyms with a higher prevalence of self-reported AAS-use and supplement use (questionnaire) showed a significantly higher proportion of observer-assessed AAS users. Analyses of individual predictors showed that AAS users were almost always young men, regular weight trainers and more often users of drugs and nutritional supplements. The higher prevalence of AAS use among gym users than in the general population makes the former an appropriate target group for AAS prevention. The connection between supplements, drugs and AAS use suggests that effective AAS prevention need to focus on several risk factors for AAS use. The clear resemblance in estimates between the observation and questionnaire data strengthen the credibility of the two methods.

Health-related quality of life (EQ-5D) among homeless persons compared to a general population sample in Stockholm County, 2006.

Science.gov (United States)

Sun, Sun; Irestig, Robert; Burström, Bo; Beijer, Ulla; Burström, Kristina

2012-03-01

To describe and compare health-related quality of life (HRQoL) among homeless persons with a general population sample in Stockholm County, 2006, and to analyse the importance of certain social determinants of health among the homeless. Face-to-face interviews with 155 homeless persons and a postal survey to a general population sample, mainly based on the same questionnaire, including questions on social determinants of health and HRQoL measured with the EQ-5D. Chronic illness was three times more common among the homeless. HRQoL was worse among homeless persons than in the general population sample: the homeless reported more problems, especially more severe problems, in all the EQ-5D dimensions and had considerably lower EQ-5D(index) and EQ(VAS) score than the general population. Most problems were reported in the dimension anxiety/depression. Among the homeless, longer duration and more severe degree of homelessness lowered HRQoL, but few determinants were statistically significantly related to HRQoL. Having mental disease significantly lowered HRQoL. This study was an attempt to include hard-to-reach groups in an assessment of population health. Homeless persons had considerably worse HRQoL than the general population and reported most problems in the dimension anxiety/depression. Some diseases may contribute to causing homelessness; others may be seen as consequences. Homeless persons are a vulnerable group in society. Further interview studies are needed based on larger sample of homeless persons to explore health determinants such as sex, age, socioeconomic factors, duration and degree of homelessness, and health-related behaviours among the homeless persons.

International Security Institutions, Domestic Politics, and Institutional Legitimacy

Science.gov (United States)

Chapman, Terrence L.

2007-01-01

Scholars have devoted considerable attention to the informational role of international institutions. However, several questions about the informational aspects of institutional behavior remain underexplored: What determines how audiences respond to institutional decisions? Through what channels does information provision affect foreign policy? To…

Financial institutions as an example of institutions of public trust

OpenAIRE

Agata Jakubowska

2013-01-01

Financial institutions are commonly known as institutions of public trust and they are fundamental for activities of other economic entities. The level of trust determines the competitive position of financial institutions. That is why care about the best standards is the most important task for these institutions. Financial institutions are called institutions of public trust and thus high professionalism and more responsibility is demanded from them. This article presents basic problems con...

Informal institutions and radical ideologies under institutional transformation

Directory of Open Access Journals (Sweden)

Irina Starodubrovskaya

2015-06-01

Full Text Available This article questions one of the central postulates of institutional economic theory, i.e., that of the sustainability and purely evolutionary changes of informal institutions. To study the phenomenon of the destruction of informal institutions and its consequences, we use the tools of sociological theory, which acknowledge that a period of intensive urbanization is characterized by anomie, i.e., a lack of norms, in which traditional institutions are destroyed, while new urban institutions have not yet taken shape. We reviewed the possible reactions of communities and individuals to the conditions of anomie, including the compensatory mechanisms of ideologies. In the case of the Dagestan Republic, we show how the proliferation of fundamentalist Islamic ideology is associated with the state of anomie and the consequences to which it could lead from an institutional point of view. The analysis of the situation in Dagestan is based on long-term field research conducted in the region.

Violence permeating daily life: a qualitative study investigating perspectives on violence among women in Karachi, Pakistan

Directory of Open Access Journals (Sweden)

Ali TS

2012-11-01

Full Text Available Tazeen S Ali,1,2,* Gunilla Krantz,3 Ingrid Mogren4,*1School of Nursing, Aga Khan University, Karachi, Pakistan; 2Department of Public Health Sciences, Division of Global Health, Karolinska Institute, Stockholm, 3Department of Public Health and Community Medicine/Social Medicine, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, 4Department of Clinical Sciences, Obstetrics and Gynecology, Umeå University, Umeå, Sweden *These authors contributed equally to this workBackground: This study explored how married women perceive situations which create family conflicts and lead to different forms of violence in urban Pakistan. In addition, it examines perceptions of consequences of violence, their adverse health effects, and how women resist violence within marital life.Methods: Five focus group discussions were conducted with 28 women in Karachi. Purposive sampling, aiming for variety in age, employment status, education, and socioeconomic status, was employed. The focus group discussions were conducted in Urdu and translated into English. Manifest and latent content analysis were applied.Results: One major theme emerged during the analysis, ie, family violence through the eyes of females. This theme was subdivided into three main categories. The first category, ie, situations provoking violence and their manifestations, elaborates on circumstances that provoke violence and situations that sustain violence. The second category, ie, actions and reactions to exposure to violence, describes consequences of ongoing violence within the family, including those that result in suicidal thoughts and actions. The final category, ie, resisting violence, describes how violence is avoided through women’s awareness and actions.Conclusion: The current study highlights how female victims of abuse are trapped in a society where violence from a partner and family members is viewed as acceptable, where divorce is unavailable to the majority, and where

Sex differences in stroke: a socioeconomic perspective

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Delbari A

2016-09-01

Full Text Available Ahmad Delbari,1 Farzane Keyghobadi,2 Yadollah Abolfathi Momtaz,1,3 Fariba Keyghobadi,2 Reza Akbari,2 Houman Kamranian,2 Mohammad Shouride Yazdi,2 Sayed Shahaboddin Tabatabaei,1 Seyed-Mohammad Fereshtehnejad4 1Iranian Research Center on Aging, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran; 2Research Center on Healthy Aging, Sabzevar University of Medical Sciences, Sabzevar, Khorasan, Iran; 3Malaysian Research Institute on Ageing (MyAgeing™, Universiti Putra Malaysia, Serdang, Selangor, Malaysia; 4Department of Neurobiology, Division of Clinical Geriatrics, Care Sciences and Society (NVS, Karolinska Institutet, Stockholm, Sweden Background: A number of studies have explored the issue of sex differences in stroke from biomedical perspective; however, there are still large gaps in the existing knowledge. The purpose of this study was to assess whether the differences in socioeconomic status and living conditions between men and women may explain the part of the sex differences in incidence and outcomes of stroke. Methods: All stroke participants aged ≥60 years admitted in Vaseie Hospital in Sabzevar, Iran, from March 21, 2013, until March 20, 2014, were included in this study. Computerized tomography and magnetic resonance imaging were used to confirm stroke. A series of χ2 tests were performed and Statistical Program for Social Sciences, Version 21.0, was used to investigate the potential differences between older men and women in stroke incidence and outcomes. Results: A total of 159 incident stroke cases were documented during 1 year. The annual rate of stroke was statistically significantly higher in elderly women than in elderly men (401 vs 357 per 100,000; P<0.001. Female elderly participants had significantly lower socioeconomic status, poorer living conditions, and higher lifetime history of depression, hypertension, and diabetes mellitus than their male counterparts. Conclusion: The findings from this study

Effect of nerve injury on the number of dorsal root ganglion neurons and autotomy behavior in adult Bax-deficient mice

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Lyu C

2017-08-01

Full Text Available Chuang Lyu,1,2 Gong-Wei Lyu,3 Aurora Martinez,4 Tie-Jun Sten Shi4 1State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of China; 2Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden; 3Department of Neurology, 1st Hospital of Harbin Medical University, Harbin, People’s Republic of China; 4Department of Biomedicine, University of Bergen, Bergen, Norway Background: The proapoptotic molecule BAX, plays an important role in mitochondrial apoptotic pathway. Dorsal root ganglion (DRG neurons depend on neurotrophic factors for survival at early developmental stages. Withdrawal of neurotrophic factors will induce apoptosis in DRG neurons, but this type of cell death can be delayed or prevented in neonatal Bax knockout (KO mice. In adult animals, evidence also shows that DRG neurons are less dependent upon neurotrophic factors for survival. However, little is known about the effect of Bax deletion on the survival of normal and denervated DRG neurons in adult mice. Methods: A unilateral sciatic nerve transection was performed in adult Bax KO mice and wild-type (WT littermates. Stereological method was employed to quantify the number of lumbar-5 DRG neurons 1 month post-surgery. Nerve injury-induced autotomy behavior was also examined on days 1, 3, and 7 post-surgery. Results: There were significantly more neurons in contralateral DRGs of KO mice as compared with WT mice. The number of neurons was reduced in ipsilateral DRGs in both KO and WT mice. No changes in size distributions of DRG neuron profiles were detected before or after nerve injury. Injury-induced autotomy behavior developed much earlier and was more serious in KO mice. Conclusion: Although postnatal death or loss of DRG neurons is partially prevented by Bax deletion, this effect cannot interfere with long-term nerve injury-induced neuronal loss. The exaggerated self

Adjunctive treatment with aripiprazole for risperidone-induced hyperprolactinemia

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Ranjbar F

2015-03-01

Full Text Available Fatemeh Ranjbar,1 Homayoun Sadeghi-Bazargani,2,3 Parisa Niari Khams,1 Asghar Arfaie,1 Azim Salari,4 Mostafa Farahbakhsh1 1Clinical Psychiatry Research Center, Tabriz University of Medical Sciences, Tabriz, East Azerbaijan, Iran; 2Road Traffic Injury Research Center, Department of Statistics & Epidemiology, Tabriz University of Medical Sciences, Tabriz, Iran; 3World Health Organization Collaborating Center on Community Safety Promotion, Karolinska Institute, Stockholm, Sweden; 4Emam Khomeini Hospital, Naghadeh, West Azerbaijan, Iran Background: Antipsychotics have been used for more than 50 years in the treatment of schizophrenia and many other psychiatric disorders. Prolactin levels usually increase in patients treated with risperidone. Aripiprazole, which has a unique effect as an antipsychotic, is a D2 receptor partial agonist. It is an atypical antipsychotic with limited extrapyramidal symptoms. Since it acts as an antagonist in hyperdopaminergic conditions and as an agonist in hypodopaminergic conditions, it does not have adverse effects on serum prolactin levels. The present study aimed to investigate the effect of aripiprazole on risperidone-induced hyperprolactinemia. Methods: This before-and-after clinical trial was performed in 30 patients. Baseline prolactin levels were measured in all patients who were candidates for treatment with risperidone. In subjects with elevated serum prolactin, aripiprazole was added to their treatment. Serum prolactin levels were measured during the first week, second week, and monthly thereafter for at least 3 months or until prolactin levels became normal. The data were analyzed using Stata version 11 software. Survival analysis and McNemar’s test were also performed. Results: The mean age of the participants was 30.8 years. Prolactin levels normalized in 23 (77% participants during the study, and menstrual disturbances normalized in 25 (83.3%. Prolactin levels normalized in most patients between days 50

The first clinical experience on efficacy of topical flutamide on melasma compared with topical hydroquinone: a randomized clinical trial

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Adalatkhah H

2015-08-01

Full Text Available Hassan Adalatkhah,1 Homayoun Sadeghi-Bazargani2,3 1Department of Dermatology, Ardabil University of Medical Sciences, Ardabil, Iran; 2Road Traffic Injury Research Center, Department of Statistics and Epidemiology, Tabriz University of Medical Sciences, Tabriz, Iran; 3Department of Public Health Sciences, Karolinska Institute, Stockholm, Sweden Background: Treatment of melasma is unsatisfactory most of the times. Hormonal role is shown to exist in pathogenesis of the melasma, and sex-hormone related drugs may have an effect on melasma.Aim: To investigate efficacy of 1% flutamide cream versus 4% hydroquinone cream on melasma.Methods: In a parallel randomized clinical trial, 74 women with melasma were allocated to receive a sunscreen along with 4% hydroquinone cream or 1% flutamide cream. Melasma Area and Severity Index (MASI, mexameter melanin assay, and patient satisfaction were investigated.Results: Mean age of the participants was 33.8 years. Mean length of time suffering from Melasma was 96.3 months. The subjects reported in average 1.1 hours per day of exposure to sunlight. Mean standardized total patient satisfaction score was 28.8 (standard deviation [SD] 17.2 in flutamide group patients versus 18 (SD 15.5 in control group (P<0.01. Regardless of treatment group, the skin darkness assessed upon MASI scales was reduced over the treatment course (P<0.001. Using mixed effects, longitudinal modeling showed better treatment efficacy based on MASI scale for flutamide group compared to the hydroquinone group (P<0.05. However, longitudinal analysis of mexameter scores did not reveal any significant difference in melanin measurements between flutamide and hydroquinone.Conclusion: Topical flutamide appeared as effective as topical hydroquinone in treating melasma using mexameter assessment but with a better MASI improvement trend and higher patient satisfaction in flutamide treatment versus topical hydroquinone. As the present study is possibly the

Effect of diet and physical exercise intervention programmes on coronary heart disease risk in smoking and non-smoking men in Sweden.

Science.gov (United States)

Näslund, G K; Fredrikson, M; Hellénius, M L; de Faire, U

1996-01-01

STUDY OBJECTIVE: To investigate differences between smokers and non-smokers in health behaviour, cardiovascular risk factors, coronary heart disease (CHD) risks, health knowledge, health attitudes, and compliance with a CHD prevention programme. DESIGN: Differences between smokers and non-smokers were studied via medical examinations, questionnaires, physical exercise activity logs, and food record sheets. Data were analysed using univariate and multivariate analyses. The five and 10 year CHD risks were assessed using the Framingham CHD risk estimate. SETTING: The Karolinska Hospital, Stockholm, and Sollentuna Primary Health Centre, Sollentuna, Sweden. PARTICIPANTS: The analyses were based on 158 healthy smoking and non-smoking men aged 35-60 years with raised cardiovascular risk factors who enrolled in controlled, randomised six month diet and exercise programmes. MAIN RESULTS: Discriminant analysis suggested that smokers, compared with non-smokers, were characterised by a higher alcohol energy percent, lower HDL cholesterol concentration, lower systolic blood pressure, and a higher plasminogen activator inhibitor-1 (PAI-1) value. Knowledge of the risk factors for CHD was not a discriminating factor. Both smokers and non-smokers increased the exercise taken, improved their diet, and lowered their CHD risk. Before, as well as after the intervention, smokers had a higher CHD risk than non-smokers. CONCLUSIONS: The best CHD prevention action that could be taken by smokers would of course be to quit smoking. Those who cannot stop should be encouraged to improve their diet and increase the amount of physical exercise they take in order to reduce the health hazards of their smoking behaviour. PMID:8762375

Orgasm-associated urinary incontinence and sexual life after radical prostatectomy.

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Nilsson, Andreas E; Carlsson, Stefan; Johansson, Eva; Jonsson, Martin N; Adding, Christofer; Nyberg, Tommy; Steineck, Gunnar; Wiklund, N Peter

2011-09-01

Involuntary release of urine during sexual climax, orgasm-associated urinary incontinence, occurs frequently after radical prostatectomy. We know little about its prevalence and its effect on sexual satisfaction. To determine the prevalence of orgasm-associated incontinence after radical prostatectomy and its effect on sexual satisfaction. Consecutive series, follow-up at one point in calendar time of men having undergone radical prostatectomy (open surgery or robot-assisted laparoscopic surgery) at Karolinska University Hospital, Stockholm, Sweden, 2002-2006. Of the 1,411 eligible men, 1,288 (91%) men completed a study-specific questionnaire. Prevalence rate of orgasm-associated incontinence. Of the 1,288 men providing information, 691 were sexually active. Altogether, 268 men reported orgasm-associated urinary incontinence, of whom 230 (86%) were otherwise continent. When comparing them with the 422 not reporting the symptom but being sexually active, we found a prevalence ratio (with 95% confidence interval) of 1.5 (1.2-1.8) for not being able to satisfy the partner, 2.1 (1.1-3.5) for avoiding sexual activity because of fear of failing, 1.5 (1.1-2.1) for low orgasmic satisfaction, and 1.4 (1.2-1.7) for having sexual intercourse infrequently. Prevalence ratios increase in prostate-cancer survivors with a higher frequency of orgasm-associated urinary incontinence. We found orgasm-associated urinary incontinence to occur among a fifth of prostate cancer survivors having undergone radical prostatectomy, most of whom are continent when not engaged in sexual activity. The symptom was associated with several aspects of sexual life. © 2011 International Society for Sexual Medicine.

Negative psychological responses of injury and rehabilitation adherence effects on return to play in competitive athletes: a systematic review and meta-analysis

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Ivarsson A

2017-03-01

Full Text Available Andreas Ivarsson,1 Ulrika Tranaeus,2,3 Urban Johnson,1 Andreas Stenling 4 1Center of Research on Welfare, Health and Sport, School of Health and Welfare, Halmstad University, Halmstad, 2Performance and Training Unit, The Swedish School of Sport and Health Sciences (GIH, 3Musculoskeletal & Sports Injury Epidemiology Center, IMM, Karolinska Institutet, Stockholm, 4Department of Psychology, Umeå University, Umeå, Sweden Abstract: Previous research offers evidence that psychological factors influence an injured athlete during the rehabilitation process. Our first objective was to conduct a systematic review and meta-analysis of the results from all published studies that examined the relationships among negative affective responses after sport injuries, rehabilitation adherence, and return to play (RTP. The second objective was to use a meta-analytic path analysis to investigate whether an indirect effect existed between negative affective responses and RTP through rehabilitation adherence. This literature review resulted in seven studies providing 14 effect sizes. The results from the meta-analysis showed that negative affective responses had a negative effect on successful RTP, whereas rehabilitation adherence had a positive effect on RTP. The results from the meta-analytic path analysis showed a weak and nonsignificant indirect effect of negative affective responses on RTP via rehabilitation adherence. These results underline the importance of providing supportive environments for injured athletes to increase the chances of successful RTP via a decrease in negative affective responses and increase in rehabilitation adherence. Keywords: affective responses, rehabilitation behaviors, return to play, sport injuries

Dolutegravir in pregnancy-effects on HIV-positive women and their infants.

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Bornhede, Riikka; Soeria-Atmadja, Sandra; Westling, Katarina; Pettersson, Karin; Navér, Lars

2018-03-01

The development of new drugs for treatment of HIV has increased the efficacy and the quality of life together with decreased unwanted side-effect for people living with HIV. The integrase inhibitor dolutegravir has in short time become part of the first-line treatment in many countries, but is not a recommended first-line drug in pregnancy. As there are few publications of dolutegravir use during pregnancy, we found it valuable to analyze the Stockholm pregnancy cohort. A retrospective analysis of all pregnant women and their infants exposed to dolutegravir at Karolinska University Hospital, 2014-August 2017. Information about maternal health, treatment, pregnancy, and child outcome were collected. Thirty-six women with singleton pregnancies were included. Four early spontaneous abortions occurred. One late termination was performed and one was lost to follow-up. Fourteen were on dolutegravir before and 22 started during pregnancy. Eighteen delivered by caesarean section, three of them because of HIV RNA > 50 copies/mL. The preeclampsia rate and the maternal liver function were normal. One infant was delivered in GW 34 on maternal indication and the rest in full term. No gross malformations were noted. All infants received antiretroviral prophylaxis and have tested negative on follow-up. No increased maternal or infant morbidity was detected in this retrospective study of dolutegravir during pregnancy. This is so far one of the largest observational studies of dolutegravir treatment during pregnancy, but the number is indeed small, and further studies are needed to evaluate the safety and efficacy.

Interprofessional education and practice in Sweden / Interprofessionelle Bildung und Praxis in Schweden

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Sottas Beat

2016-05-01

Full Text Available There are some significant differences between the health systems in German speaking Europe and Sweden: In Sweden, the number of hospitals is small, caregiving services in the hospital and ambulatory sector are integrated, health professionals with university degrees are granted extended competencies and rights incl. first line consultation and limited prescription. Education is designed to prepare for these functions and responsibilities. It started more than 30 years ago when Linköping implemented the OECD-model of Health Universities. Interprofessional teaching, common learning of the various tracks and training on real patients are constitutive elements of this novel approach. Karolinska University in Stockholm adopted the model in 1998 and gave way to a nationwide reform. A recommendation of the German Science Council regarding training of health professionals, published 2012, drew the attention of educators to this approach. The paper explains the circumstances of the consolidation of this concept. It is important to realize that overarching governance principles and measures deriving from health and education policy are of crucial importance. They evolve from evaluations of needs carried out by the regional health agencies which lead to conditional mandates and financial incentives to the education sector. Moreover, decisions taken by the national board for accreditation and quality assurance take also in account the goals set and the outcomes in education and caregiving. Outside Sweden they would be considered an inappropriate limitation of academic freedom.The paper ends with a reflection of impressions collected during a study trip and shows some lessons to be learnt from the Swedish education and practice.

Susceptibility to mortality related to temperature and heat and cold wave duration in the population of Stockholm County, Sweden

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Joacim Rocklöv

2014-03-01

Full Text Available Background: Ambient temperatures can cause an increase in mortality. A better understanding is needed of how health status and other factors modify the risk associated with high and low temperatures, to improve the basis of preventive measures. Differences in susceptibility to temperature and to heat and cold wave duration are relatively unexplored. Objectives: We studied the associations between mortality and temperature and heat and cold wave duration, stratified by age and individual and medical factors. Methods: Deaths among all residents of Stockholm County between 1990 and 2002 were linked to discharge diagnosis data from hospital admissions, and associations were examined using the time stratified case-crossover design. Analyses were stratified by gender, age, pre-existing disease, country of origin, and municipality level wealth, and adjusted for potential confounding factors. Results: The effect on mortality by heat wave duration was higher for lower ages, in areas with lower wealth, for hospitalized patients younger than age 65. Odds were elevated among females younger than age 65, in groups with a previous hospital admission for mental disorders, and in persons with previous cardiovascular disease. Gradual increases in summer temperatures were associated with mortality in people older than 80 years, and with mortality in groups with a previous myocardial infarction and with chronic obstructive pulmonary disease (COPD in the population younger than 65 years. During winter, mortality was associated with a decrease in temperature particularly in men and with the duration of cold spells for the population older than 80. A history of hospitalization for myocardial infarction increased the odds associated with cold temperatures among the population older than 65. Previous mental disease or substance abuse increased the odds of death among the population younger than 65. Conclusion: To increase effectiveness, we suggest preventive efforts

Symptoms and Character Traits in Patients Selected for Long-term Psychodynamic Psychotherapy

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Wilczek, Alexander; Weinryb, Robert M.; Gustavsson, Petter J.; Barber, Jacques P.; Schubert, Johan; ÅSBERG, Marie

1998-01-01

In this naturalistic study of 55 outpatients selected for long-term psychodynamic psychotherapy, two Swedish assessment instruments are presented (the Karolinska Psychodynamic Profile and the Karolinska Scales of Personality), and the significance of psychodynamic criteria for the selection of patients is discussed. Thirty patients (55%) fulfilled criteria for a DSM-III-R diagnosis. The most prominent psychodynamically defined character pathology was found in the areas of coping with aggressive affects; dependency and separation; frustration tolerance; and impulse control. Some psychodynamically defined character traits, particularly poor frustration tolerance, were related to symptomatic suffering. PMID:9407473

Further development and performance evaluation of the autonomous sailing boat Maribot Vane

OpenAIRE

Dhomé, Ulysse

2018-01-01

This paper describes the ongoing development of Maribot Vane, an autonomous sailing vessel at the Maritime Robotics Laboratory of KTH, the Royal Institute of Technology, Stockholm. There is an ac-celerating need for ocean sensing where autonomous vehicles can play a key role in assisting scientists with environmental monitoring and collecting oceanographic data. The purpose of Maribot Vane is to offer a sus-tainable alternative for these autonomous missions by using wind and an energy efficie...

The Swedish fusion research programme on magnetic confinement 1978

International Nuclear Information System (INIS)

Lehnert, B.

1978-02-01

A review is given on the activities and plans for research on plasma physics and controlled fusion at the Royal Institute of Technology in Stockholm, with descriptions and motivations of the research lines being conducted. These activities include investigations on plasma-neutral gas interaction, development of special principles for plasma stabilization, magnetic confinement schemes being based mainly on poloidal fields, as well as the generation, heating, and diagnostics of plasmas being ''impermeable'' to neutral gas. (author)

Commercialization possibilities of Stirling engine technology for microscale power generation in Sweden

OpenAIRE

Backman, Peter

2012-01-01

The presented master’s thesis has evaluated the possibility of commercializing a research project at the Royal Institute of Technologys (KTH) Department of Energy Technology (EGI) in Stockholm, Sweden, where a Stirling engine is used for renewable microscale power generation.  The purpose of the thesis has been to evaluate the current market situation and future prospects by composing a business plan under the working name MicroStirling. In the business plan a potential target group consistin...

Institutional advantage

NARCIS (Netherlands)

Martin, Xavier

Is there such a thing as institutional advantage—and what does it mean for the study of corporate competitive advantage? In this article, I develop the concept of institutional competitive advantage, as distinct from plain competitive advantage and from comparative institutional advantage. I first

California Institute for Water Resources - California Institute for Water

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Resources Skip to Content Menu California Institute for Water Resources Share Print Site Map Resources Publications Keep in Touch QUICK LINKS Our Blog: The Confluence Drought & Water Information University of California California Institute for Water Resources California Institute for Water Resources

Green energy. Biomass fuels and the environment

International Nuclear Information System (INIS)

1991-01-01

maximizing their positive ones. The study was undertaken for UNEP by the Beijer Institute in Stockholm (now the Stockholm Environment Institute) during 1988-90. The results have been published as a joint UNEP/Stockholm Environment Institute publication, Bioenergy and the Environment, by Westview Press. This volume is intended for professionals in the field, such as those working in environmental management and energy planning, and to aid decision makers charged with assessing the impacts of alternative energy systems. This booklet - Green Energy: biomass and the environment - is a popular version of the technical study and is based largely, though not exclusively, on it. It is intended primarily for those who have a special interest in the subject but who do not have any professional background in the area. It is hoped that members of the general public, and of schools and universities, will also find it timely and useful

Klebsiella variicola is a frequent cause of bloodstream infection in the stockholm area, and associated with higher mortality compared to K. pneumoniae.

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Makaoui Maatallah

Full Text Available Clinical isolates of Klebsiella pneumoniae are divided into three phylogroups and differ in their virulence factor contents. The aim of this study was to determine an association between phylogroup, virulence factors and mortality following bloodstream infection (BSI caused by Klebsiella pneumoniae. Isolates from all adult patients with BSI caused by K. pneumoniae admitted to Karolinska University Hospital, Solna between 2007 and 2009 (n = 139 were included in the study. Phylogenetic analysis was performed based on multilocus sequence typing (MLST data. Testing for mucoid phenotype, multiplex PCR determining serotypes K1, K2, K5, K20, K54 and K57, and testing for virulence factors connected to more severe disease in previous studies, was also performed. Data was retrieved from medical records including age, sex, comorbidity, central and urinary catheters, time to adequate treatment, hospital-acquired infection, and mortality, to identify risk factors. The primary end-point was 30- day mortality. The three K. pneumoniae phylogroups were represented: KpI (n = 96, KpII (corresponding to K. quasipneumoniae, n = 9 and KpIII (corresponding to K. variicola, n = 34. Phylogroups were not significantly different in baseline characteristics. Overall, the 30-day mortality was 24/139 (17.3%. Isolates belonging to KpIII were associated with the highest 30-day mortality (10/34 cases, 29.4%, whereas KpI isolates were associated with mortality in 13/96 cases (13.5%. This difference was significant both in univariate statistical analysis (P = 0.037 and in multivariate analysis adjusting for age and comorbidity (OR 3.03 (95% CI: 1.10-8.36. Only three of the isolates causing mortality within 30 days belonged to any of the virulent serotypes (K54, n = 1, had a mucoid phenotype (n = 1 and/or contained virulence genes (wcaG n = 1 and wcaG/allS n = 1. In conclusion, the results indicate higher mortality among patients infected with

Klebsiella variicola Is a Frequent Cause of Bloodstream Infection in the Stockholm Area, and Associated with Higher Mortality Compared to K. pneumoniae

Science.gov (United States)

Kabir, Muhammad Humaun; Bakhrouf, Amina; Kalin, Mats; Nauclér, Pontus; Brisse, Sylvain; Giske, Christian G.

2014-01-01

Clinical isolates of Klebsiella pneumoniae are divided into three phylogroups and differ in their virulence factor contents. The aim of this study was to determine an association between phylogroup, virulence factors and mortality following bloodstream infection (BSI) caused by Klebsiella pneumoniae. Isolates from all adult patients with BSI caused by K. pneumoniae admitted to Karolinska University Hospital, Solna between 2007 and 2009 (n = 139) were included in the study. Phylogenetic analysis was performed based on multilocus sequence typing (MLST) data. Testing for mucoid phenotype, multiplex PCR determining serotypes K1, K2, K5, K20, K54 and K57, and testing for virulence factors connected to more severe disease in previous studies, was also performed. Data was retrieved from medical records including age, sex, comorbidity, central and urinary catheters, time to adequate treatment, hospital-acquired infection, and mortality, to identify risk factors. The primary end-point was 30- day mortality. The three K. pneumoniae phylogroups were represented: KpI (n = 96), KpII (corresponding to K. quasipneumoniae, n = 9) and KpIII (corresponding to K. variicola, n = 34). Phylogroups were not significantly different in baseline characteristics. Overall, the 30-day mortality was 24/139 (17.3%). Isolates belonging to KpIII were associated with the highest 30-day mortality (10/34 cases, 29.4%), whereas KpI isolates were associated with mortality in 13/96 cases (13.5%). This difference was significant both in univariate statistical analysis (P = 0.037) and in multivariate analysis adjusting for age and comorbidity (OR 3.03 (95% CI: 1.10–8.36). Only three of the isolates causing mortality within 30 days belonged to any of the virulent serotypes (K54, n = 1), had a mucoid phenotype (n = 1) and/or contained virulence genes (wcaG n = 1 and wcaG/allS n = 1). In conclusion, the results indicate higher mortality among patients infected with

Acute management of traumatic spinal cord injury in a Greek and a Swedish region: a prospective, population-based study.

Science.gov (United States)

Divanoglou, A; Seiger, A; Levi, R

2010-06-01

Prospective, population-based study. This paper is part of the Stockholm Thessaloniki Acute Traumatic Spinal Cord Injury Study (STATSCIS). To characterize patient populations and to compare acute management after traumatic spinal cord injury (TSCI). The Greater Thessaloniki region in Greece and the Greater Stockholm region in Sweden. Inception cohorts with acute TSCI that were hospitalized during the study period, that is September 2006 to October 2007, were identified. Overall, 81 out of 87 cases consented to inclusion in Thessaloniki and 47 out of 49 in Stockholm. Data from Thessaloniki were collected through physical examinations, medical record reviews and communication with TSCI cases and medical teams. Data from Stockholm were retrieved from the Nordic Spinal Cord Injury Registry. There were no significant differences between study groups with regard to core clinical characteristics. In contrast, there were significant differences in (1) transfer logistics from the scene of trauma to a tertiary-level hospital (number of intermediate admissions, modes of transportation and duration of transfer) and (2) acute key therapeutic interventions, that is, the use of mechanical ventilation (49% in Thessaloniki versus 20% in Stockholm), and performance of tracheostomy (36% in Thessaloniki versus 15% in Stockholm); spinal surgery was performed significantly more often and earlier in Stockholm than in Thessaloniki. Despite largely similar core clinical characteristics, Stockholm and Thessaloniki cases underwent significantly different acute management, most probably to be attributed to adaptations to the differing regional approaches of care one following a systematic approach of SCI care and the other not.

Forschungszentrum Rossendorf, Institute of Safety Research. Annual report 2001

International Nuclear Information System (INIS)

Weiss, F.P.; Rindelhardt, U.

2002-06-01

In the reporting period, the ISR performed 9 meetings and workshops with international participation. It is especially worth mentioning the workshop on 'Process Control and Condition Monitoring in Chemical Plants' that was conducted for the first time, and the concluding conference of the DFG Innovationskolleg 'Magneto-Hydrodynamics of Electrically Conducting Fluids'. At the ROCOM test facility (Rossendorf Coolant Mixing facility), a large series of experiments was performed dedicated to coolant mixing phenomena in PWRs during boron dilution and cold water transients. CFD models were validated against those experiments and a so called semi-analytical mixing model was developed. By coupling that semi-analytical model with the DYN3D reactor dynamics code it could be shown that a shut down reactor gets re-critical when a plug of 36 m 3 deionated water enters the core after switching on the first main coolant pump. However, that deionated plug does not lead to non-allowed high coolant pressure or fuel temperatures. The behavior of a RPV lower callotte during a severe accident with melt slumping into the lower plenum is studied in 1:10 test at Royal Institute of Technology Stockholm. At the ISR computational methods were developed for pre- and post-test calculations of those experiments in order to predict the time and mode of RPV failure. The temperature, as well as location, and time of the RPV failure were found in good agreement with the experiment. Two patents resulted from those studies. One of them proposes a creep stool to mechanically support the RPV deformed by creeping, and the flooding of the reactor pit for ex vessel cooling of the melt inside the vessel. Such measures extend the time till RPV failure and offer the possibility for additional accident management procedures that can prevent the RPV meltthrough. The MHD department of ISR was especially successful in 2001. In the framework of the Bundesministerium fuer Bildung und Forschung (BMBF) initiative

Institutional Repositories: The Experience of Master's and Baccalaureate Institutions

Science.gov (United States)

Markey, Karen; St. Jean, Beth; Soo, Young Rieh; Yakel, Elizabeth; Kim, Jihyun

2008-01-01

In 2006, MIRACLE Project investigators censused library directors at all U.S. academic institutions about their activities planning, pilot testing, and implementing the institutional repositories on their campuses. Out of 446 respondents, 289 (64.8 percent) were from master's and baccalaureate institutions (M&BIs) where few operational…

Interleukin-16-producing NK cells and T-cells in the blood of tobacco smokers with and without COPD

Directory of Open Access Journals (Sweden)

Andersson A

2016-09-01

Full Text Available Anders Andersson,1,* Carina Malmhäll,2,* Birgitta Houltz,1 Sara Tengvall,1 Margareta Sjöstrand,2 Ingemar Qvarfordt,1 Anders Lindén,3 Apostolos Bossios2 1Respiratory Medicine and Allergology, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden; 2Krefting Research Center, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden; 3Unit for Lung and Airway Research, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden *These authors contributed equally to this work Background: Long-term exposure to tobacco smoke causes local inflammation in the airways that involves not only innate immune cells, including NK cells, but also adaptive immune cells such as cytotoxic (CD8+ and helper (CD4+ T-cells. We have previously demonstrated that long-term tobacco smoking increases extracellular concentration of the CD4+-recruiting cytokine interleukin (IL-16 locally in the airways. Here, we hypothesized that tobacco smoking alters IL-16 biology at the systemic level and that this effect involves oxygen free radicals (OFR.Methods: We quantified extracellular IL-16 protein (ELISA and intracellular IL-16 in NK cells, T-cells, B-cells, and monocytes (flow cytometry in blood samples from long-term tobacco smokers with and without chronic obstructive pulmonary disease (COPD and in never-smokers. NK cells from healthy blood donors were stimulated with water-soluble tobacco smoke components (cigarette smoke extract with or without an OFR scavenger (glutathione in vitro and followed by quantification of IL-16 protein.Results: The extracellular concentrations of IL-16 protein in blood did not display any substantial differences between groups. Notably, intracellular IL-16 protein was detected in all types of blood leukocytes. All long-term smokers displayed

Institutional upbringing

DEFF Research Database (Denmark)

Gulløv, Eva

2008-01-01

In the chapter, I discuss the role day care institutions play in the construction of the idea of proper childhood in Denmark. Drawing on findings from research on ethnic minority children in two Danish day care institutions, I begin with a discussion of how childcare institutions act as civilising...... agents, empowered with the legitimate right to define and control normality and proper ways of behaving oneself. I aim to show how institutions come to define the normal child and proper childhood in accordance with current efforts toward reinventing national culture, exemplified by legislation requiring...... current testing of Danish language fluency levels among pre-school minority children. Testing language skills marks and defines distinctions that reinforce images of deviance that, in turn, legitimize initiatives to enrol children, specifically minority children, in child care institutions....

Furthering critical institutionalism

Directory of Open Access Journals (Sweden)

Frances Dalton Cleaver

2015-03-01

Full Text Available This special issue furthers the study of natural resource management from a critical institutional perspective. Critical institutionalism (CI is a contemporary body of thought that explores how institutions dynamically mediate relationships between people, natural resources and society. It focuses on the complexity of institutions entwined in everyday social life, their historical formation, the interplay between formal and informal, traditional and modern arrangements, and the power relations that animate them. In such perspectives a social justice lens is often used to scrutinise the outcomes of institutional processes. We argue here that critical institutional approaches have potentially much to offer commons scholarship, particularly through the explanatory power of the concept of bricolage for better understanding institutional change.  Critical institutional approaches, gathering momentum over the past 15 years or so, have excited considerable interest but the insights generated from different disciplinary perspectives remain insufficiently synthesised. Analyses emphasising complexity can be relatively illegible to policy-makers, a fact which lessens their reach. This special issue therefore aims to synthesise critical institutional ideas and so to lay the foundation for moving beyond the emergent stage to make meaningful academic and policy impact. In bringing together papers here we define and synthesise key themes of critical institutionalism, outline the concept of institutional bricolage and identity some key challenges facing this school of thought.

Fostering Institutional Creativity at Multiple Levels: Towards Facilitated Institutional Bricolage

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Douglas J. Merrey

2012-02-01

Full Text Available Problems occur when institutional arrangements for collective management of food and water systems fail to meet demands. Many of the problems characterising river basins and other collectively managed water resource systems can be ascribed largely to the failure of institutions to enable problems beyond the individual to be managed collectively. The nature of these demands, and the institutional responses to them, vary widely and are not amenable to simple definitions and prescriptions. We begin with a brief review of conventional approaches to analysing institutions and organisations, focused largely, but not exclusively, on river basins. We observe that attempts to reduce the institutional landscape of river basins to over-simplistic formulas introduces more problems than solutions, because the reality is that institutions evolve through complex creative processes that adopt and adapt diverse ingredients – rather like making a stew. Despite such intricacies, institutions are clearly non-random, so we continue a search for a means of describing them. We adopt the concept of bricolage, as proposed by Cleaver and others, and use it to show the value of promoting and facilitating an organic creative approach to building and strengthening river basin and other water management institutions.

Institutional plan -- Institute of Nuclear Power Operations, 1993

International Nuclear Information System (INIS)

1993-01-01

The US nuclear electric utility industry established the Institute of Nuclear Power Operations (INPO) in 1979 to promote the highest levels of safety and reliability -- to promote excellence -- in the operation of its nuclear plants. After its formation, the Institute grew from a handful of on-loan personnel in late 1979 to an established work force of more than 400 permanent and on-loan personnel. INPO's early years were marked by growth and evolution of its programs and organization. The Institute now focuses primarily on the effectiveness and enhancement of established programs and activities. For INPO to carry out its role, it must have the support of its members and participants and a cooperative but independent relationship with the NRC. A basis for that support and cooperation is an understanding of INPO's role. This Institutional Plan is intended to provide that understanding by defining the Institute's role and its major programs. This plan considers the existing and projected needs of the industry and the overall environment in which INPO and its members and participants operate

TTI Phase 2 Institutional Support: The Institute of Economic Affairs ...

International Development Research Centre (IDRC) Digital Library (Canada)

TTI Phase 2 Institutional Support: The Institute of Economic Affairs, Ghana ... the Institute of Economic Affairs' (IEA-Ghana) role as a credible public policy ... public policy, facilitate private sector-led economic growth, and strengthen democracy.

How are homeless people treated in the healthcare system and other societal institutions? Study of their experiences and trust.

Science.gov (United States)

Irestig, Robert; Burström, Kristina; Wessel, Maja; Lynöe, Niels

2010-05-01

To elucidate the perceived treatment that the homeless have received from the healthcare and other societal organisations and to present homeless persons' trust in the healthcare system and suggestions of necessary changes for improving it. Homeless individuals in special houses and institutions in the County of Stockholm were asked to answer a short version of a public health survey, including added questions about how they experienced the healthcare providers' attitudes towards them and how much trust they had in the healthcare system. A total of 155 homeless persons (123 male and 32 female) were interviewed. Three-quarters of the participants stated that they had fairly or very high trust in healthcare services and also felt that they had been fairly or very well treated. Fewer females than males reported being treated well and they declared a lower degree of trust in the healthcare system. The homeless suggest that extra resources be set aside to organise their healthcare, including a higher level of knowledge of the medical problems prevailing in the group. Those who felt badly treated also asked for less neglect and disrespect from the healthcare staff. Even though a majority experience that they are being well treated within the healthcare system, the study also indicated disadvantages in the treatment of homeless persons in Sweden. The study also reveals an imbalance between the official ethical framework in Sweden and of the specific moral of some individual healthcare providers. One way to facilitate their entry into the healthcare system might be to create special surgeries for the homeless.

Institutional Churn: Institutional Change in United Kingdom Higher Education

Science.gov (United States)

Tight, Malcolm

2013-01-01

This article considers how higher education institutions change over time, using the United Kingdom system as an exemplar, and focusing on the 15-year period between 1994/95 and 2009/10. While there are many aspects of institutional change worthy of study, the focus here is on how institutions appear to others. Thus, the article examines the…

The calibration of the solid state nuclear track detector LR 115 for radon measurements

CERN Document Server

Gericke, C; Jönsson, G; Freyer, K; Treutler, H C; Enge, W

1999-01-01

An experimental calibration of indoor room and outdoor soil detector devices which are based on LR 115 as sensitive element has taken place at the Swedish Radiation Protection Institute in Stockholm (Sweden) in 1994 and 1996, at the Physikalisch-Technischen Bundesanstalt in Braunschweig (Germany) in 1997 and at the Umweltforschungszentrum Leipzig-Halle (Germany) in 1997. Special properties of the used solid state nuclear track detector (SSNTD) material LR 115 have been measured to define the application of the experimental calibration.

Radon in housing

International Nuclear Information System (INIS)

1984-04-01

The enclosed material deals with the substantial efforts made until now to control the levels of radon in Sweden dwellings. It is meant as a source material for the several publications which have emerged from the National Institute of Radiation Protection in Stockholm during 1983 and 1984. The first document is a translation of chapter 16, the deliberations of the Swedish Radon Commission, appointed by the government in 1979. Comments on the report of the commission were solicited before 1 October, 1983. (author)

From Institutional Change to Experimentalist Institutions

DEFF Research Database (Denmark)

Hull Kristensen, Peer; Morgan, Glenn

2012-01-01

Institutionalist theory has shown how work and employment relations are shaped by national contexts. Recent developments in these theories have been increasingly concerned with the issue of institutional change. This reflects a shift in the nature of the competitive environment of firms from...... and institutions. In this paper, we emphasize that in the current context of globalization, firms and actors within firms are continuously developing the way in which they organize work and employment to produce goods and services that are competitive in global markets. The paper argues that new market conditions...... lead firms to constant experimentation in work organization as they seek to position themselves within systems of production and innovation that are global in nature. This creates a pressure for institutional change to facilitate the process of firm-level experimentation; it also tends to create...

Recurring alcohol-related care between 1998 and 2007 among people treated for an alcohol-related disorder in 1997: A register study in Stockholm County

Directory of Open Access Journals (Sweden)

Kåreholt Ingemar

2011-07-01

Full Text Available Abstract Background Inpatient care for alcohol intoxication is increasing in Sweden, especially among young women. Since it is well known that alcohol disorder is a chronic relapsing illness, this study examines the extent to which people return for more care. Method All inpatients with alcohol-related diagnoses in Stockholm County during 1997 were followed prospectively to 2007 through registers. The proportion reappearing for the same diagnosis, other alcohol-related inpatient, or outpatient care each year after baseline, as well as the number of years the inpatients reappeared were calculated (n = 2735. Three diagnoses were examined separately; alcohol dependence, harmful use of alcohol, and alcohol intoxication. Results Three out of five inpatients with an alcohol diagnoses reappeared for more alcohol-related inpatient care during the following decade. The proportion returning was largest the year after baseline and then decreased curvilinearly over time. The inclusion of outpatient care increased proportions, but did not change patterns. Of those with an alcohol dependence diagnosis at baseline 42 percent returned for more alcohol-related inpatient care the first, 28 percent the fifth, and 25 percent the tenth year. Corresponding proportions for harmful use and intoxication were smaller. One in five among those with an alcohol dependence returned for more than five of the ten years. Ordered logistic regressions confirmed that besides diagnosis, age and gender were independently related to the number of years returning to care. Conclusions While middle-aged males with alcohol dependence were in a revolving door, young female inpatients with intoxication diagnosis returned to a comparably lower degree.

Stockholm/Copenhagen/Oslo

DEFF Research Database (Denmark)

Cortsen, Rikke Platz

2015-01-01

The Swedish comic strip Rocky has been translated to Danish and Norwegian and, in this process, its protagonist has changed nationality and hometown; Danish and Norwegian readers experience him as someone from their own cultural sphere. This article uses geographer Doreen Massey’s concept of place...... as progressive and structural comics theory to understand how this transition is possible. The article analyzes how different places in Rocky are constructed through the use of image and text and specifically, how the lack of place-specific visual elements and the strip’s extensive use of text is central to how...

The "Clubs against Drugs" program in Stockholm, Sweden: two cross-sectional surveys examining drug use among staff at licensed premises

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Gripenberg Abdon Johanna

2011-02-01

Full Text Available Abstract Background The objective of this study is to examine self-reported drug use among staff at licensed premises, types of drugs used, attitudes towards drugs, and observed drug use among guests. Results are presented from two measurement points (in 2001 and 2007/08. This study was carried out within the framework of the "Clubs against Drugs" program, which is a community-based multi-component intervention targeting licensed premises in Stockholm, Sweden. Methods Two cross-sectional surveys were conducted, the first in 2001 and the second in 2007/08. Staff at licensed premises attending server training were asked to participate in the anonymous survey. A survey was administered in a classroom setting and consisted of four sections: 1 demographics, 2 respondents' own drug use experience, 3 respondents' attitudes towards drug use, and 4 observed drug use among guests at licensed premises. Results Data were collected from 446 staff in 2001 and 677 staff in 2007/08. The four most commonly used drugs among staff were cannabis, cocaine, amphetamine, and ecstasy. The highest rates of drug use were reported by staff in the two youngest age groups, i.e., those younger than 25 and those between the ages of 25 and 29. In 2007/08 staff reported significantly lower rates of drug use than staff in 2001. Last year drug use for the sample in 2007/08 was 19% compared to 27% for the 2001 sample. While drug-using staff compared to non drug-using staff reported more observations of drug use among guests, they were less inclined to intervene. Overall, staff reported restrictive attitudes towards drugs. Conclusions The prevalence of life-time and last year drug use among staff at licensed premises is high compared to the general population in Sweden. Lower rates of self-reported drug use among staff were reported in 2007/08. The results of this study highlight that staff at licensed premises represent an important target population in club drug prevention

Dental treatment and caries prevention preceding treatment under general anaesthesia in healthy children and adolescents: a retrospective cohort study.

Science.gov (United States)

Grindefjord, M; Persson, J; Jansson, L; Tsilingaridis, G

2018-04-01

This was to examine healthy children and adolescents treated under general anaesthesia (GA) and a matched control group not receiving GA to compare treatment and preventive care received prior to GA treatment. This retrospective cohort study included 71 healthy subjects and 213 age- and gender-matched control subjects. The treatment group had been consecutively referred from the Public Dental Health Service (PDS) in Stockholm to the Department of Paediatric Dentistry, Eastman Institute, Stockholm during 2006-2007. Data was extracted from the patient records at the PDS, including variables such as number of dental visits, treatment/prophylaxis prior to GA, number of missed and cancelled appointments, and number of decayed teeth. On average, the treatment group had significantly more decayed teeth (p general dentists to paediatric specialists had no behaviour management treatment and nearly half, no preventive treatment, despite receiving significantly more operative treatment compared with matched controls. General dentists should target high caries-risk patients for additional behaviour management and preventive care to reduce the need for treatment under GA.

Association between childhood adversity and a diagnosis of personality disorder in young adulthood: a cohort study of 107,287 individuals in Stockholm County.

Science.gov (United States)

Björkenstam, Emma; Ekselius, Lisa; Burström, Bo; Kosidou, Kyriaki; Björkenstam, Charlotte

2017-08-01

Childhood adversity (CA) may increase the risk for later developing of personality disorder (PD). However, less is known about the association between cumulative CA and PD, and the role of childhood psychopathology and school performance. The current study examined the relationship between a range of CAs and a diagnosis of PD in young adulthood, and the roles of childhood psychopathology and school performance in this relationship. All individuals born in Stockholm County 1987-1991 (n = 107,287) constituted our cohort. Seven CAs were measured between birth and age 14: familial death, parental criminality, parental substance abuse and psychiatric morbidity, parental separation and/or single-parent household, household public assistance and residential instability. Individuals were followed from their 18th birthday until they were diagnosed with PD or until end of follow-up (December 31st 2011). Adjusted estimates of risk of PD were calculated as hazard ratios (HR) with 95% confidence intervals (CI). Associations were observed between cumulative CA and PD. During the follow-up 770 individuals (0.7%) were diagnosed with PD. Individuals exposed to 3+ CAs had the highest risks of being diagnosed with PD (HR 3.0, 95% CI 2.4-3.7). Childhood psychopathology and low school grades further increased the risk of PD among individuals exposed to CA. Cumulative CA is strongly associated with a diagnosis of PD in young adulthood. Our findings indicate that special attention should be given in schools and health services to children exposed to adversities to prevent decline in school performance, and to detect vulnerable individuals that may be on negative life-course trajectories.

Institutional failures and transaction costs of Bulgarian private research institutes

OpenAIRE

Nozharov, Shteryo

2016-01-01

The paper analyses the reasons for poor performance of private research institutes in Bulgaria. In this regard the Institutional Economics methods are used. A connection between smart growth policy goals and Bulgarian membership in EU is made. The gaps in the institutional environment are identified as well as measures for their elimination are proposed. The main accent of the study is put on the identification of transaction costs, arisen as a result of the failures of the institutional envi...

A 9-year follow-up of a self-management group intervention for persistent neck pain in primary health care: a randomized controlled trial

Directory of Open Access Journals (Sweden)

Gustavsson C

2016-12-01

Full Text Available Catharina Gustavsson,1,2 Lena von Koch1,3,4 1Center for Clinical Research Dalarna, Department of Public Health and Caring Science, Uppsala University, Uppsala, 2School of Education, Health and Social Studies, Dalarna University, Falun, 3Department of Neurobiology, Care Science and Society, Karolinska Institutet, 4Department of Neurology, Karolinska University Hospital, Stockholm, Sweden Background and objective: In previous short-term and 2-year follow-ups, a pain and stress self-management group intervention (PASS had better effect on pain-related disability, self-efficacy, catastrophizing, and perceived pain control than individually administered physiotherapy (IAPT for patients with persistent tension-type neck pain. Studies that have evaluated long-term effects of self-management approaches toward persistent neck pain are sparse. The objective of this study was to compare pain-related disability, self-efficacy for activities of daily living (ADL, catastrophizing, pain, pain control, use of analgesics, and health care utilization in people with persistent tension-type neck pain 9 years after they received the PASS or IAPT. Materials and methods: Of 156 people (PASS, n = 77; IAPT, n = 79 originally included in a randomized controlled trial, 129 people (PASS, n = 63; IAPT, n = 66 were eligible and were approached for the 9-year follow-up. They were sent a self-assessment questionnaire, comprising the Neck Disability Index, the Self-Efficacy Scale, the Coping Strategies Questionnaire, and questions regarding pain, analgesics, and health care utilization. Mixed linear models for repeated measures analysis or generalized estimating equations were used to evaluate the differences between groups and within groups over time (baseline, previous follow-ups, and 9-year follow-up and the interaction effect of “time by group”. Results: Ninety-four participants (73% responded (PASS, n = 48; IAPT, n = 46. At 9 years, PASS participants reported less

Gender differences in the T-cell profiles of the airways in COPD patients associated with clinical phenotypes

Directory of Open Access Journals (Sweden)

Forsslund H

2016-12-01

Full Text Available Helena Forsslund,1 Mingxing Yang,1 Mikael Mikko,1 Reza Karimi,1 Sven Nyrén,2 Benita Engvall,1 Johan Grunewald,1 Heta Merikallio,1,3 Riitta Kaarteenaho,3–5 Jan Wahlström,1 Åsa M Wheelock,1 C Magnus Sköld1 1Department of Medicine Solna and Centre for Molecular Medicine, Respiratory Medicine Unit, 2Department of Molecular Medicine and Surgery, Karolinska Institutet and Karolinska University Hospital Solna, Stockholm, Sweden; 3Respiratory Research Unit and Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland; 4Unit of Medicine and Clinical Research, Pulmonary Division, University of Eastern Finland, 5Center for Medicine and Clinical Research, Division of Respiratory Medicine, Kuopio University Hospital, Kuopio, Finland Abstract: T lymphocytes are believed to play an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD. How T cells are recruited to the lungs and contribute to the inflammatory process is largely unknown. COPD is a heterogeneous disease, and discriminating disease phenotypes based on distinct molecular and cellular pathways may provide new approaches for individualized diagnosis and therapies. Bronchoalveolar lavage (BAL and blood samples were obtained from 40 never-smokers, 40 smokers with normal lung function, and 38 COPD patients. T-cell chemokine receptor expression was analyzed with flow cytometry, and soluble BAL cytokines and chemokines were measured using a cytokine multiplex assay. Correlations with gender and clinical characteristics including lung imaging were investigated using multivariate modeling. Th1/Tc1- and Th2/Tc2-associated soluble analytes and T-cell chemokine receptors were analyzed as cumulative Th1/Tc1 and Th2/Tc2 immune responses. A higher expression of chemokine receptor CCR5 on CD8+ T cells in BAL and higher percentage of CXCR3+CD8+ T cells in blood was found in female smokers with COPD compared to those without COPD. CCR5 expression

Differences in symptoms, functioning, and quality of life between women on long-term sick-leave with musculoskeletal pain with and without concomitant depression

Directory of Open Access Journals (Sweden)

Schüldt Ekholm K

2011-08-01

Full Text Available Gunilla Brodda Jansen1,2, Jürgen Linder3, Kristina Schüldt Ekholm4,5, Jan Ekholm2,41Department of Pain Management, Capio St Göran’s Hospital, 2Department of Clinical Sciences, Division of Rehabilitation Medicine, Karolinska Institutet, Danderyd Hospital, 3Diagnostic Centre, Division of Psychiatry, Department of Clinical Neuroscience, Karolinska Institutet, 4Stockholm Rehabilitation Medicine University Clinic, Danderyd Hospital; 5Section of Rehabilitation Science, Department of Health Sciences, Mid Sweden University, Campus Östersund, SwedenObjective: The aim was to describe the differences in symptoms, functioning and quality of life between women on long-term sick-leave due to protracted musculoskeletal pain with and without concomitant depression.Design: Descriptive and comparisons with/without comorbid depression.Methods: 332 female patients were examined by three specialist physicians in psychiatry, orthopedic surgery, and rehabilitation medicine and assigned to four groups according to the ICD-10 diagnoses: low back/joint disorders (LBJ, n = 150, myalgia (M, n = 43, fibromyalgia (FM, n = 87, or depression without somatic pain diagnosis (DE, n = 52.Results: Patients with somatic pain conditions LBJ, M, or FM showed more activity-related difficulties if concomitant depression was present during the activities ‘focusing attention’, ‘making decisions’, and ‘undertaking a single task’; and in the domains ‘energy level’, ‘memory functions’, ‘emotional functions’, and ‘optimism/pessimism’. Patients with FM and concomitant depression perceived higher pain intensity than patients in group DE. No statistically significant differences in physically related activities were noted between each of the somatic pain conditions with and without coexisting depression. FM patients with coexisting depression reported fewer painful sites on their pain drawings compared with FM-patients without depression. Patients with LBJ or FM

Navigating Institutions and Institutional Leadership to Address Sexual Violence

Science.gov (United States)

Sisneros, Kathy; Rivera, Monica

2018-01-01

Using an institutional example, this chapter offers strategies to effectively navigate institutional culture, processes, and structures to engage the entire campus community in addressing sexual violence.

Institutional Investors

DEFF Research Database (Denmark)

Birkmose, Hanne Søndergaard; Strand, Therese

Research Question/Issue: Institutional investors are facing increased pressure and threats of legislation from the European Union to abandon passive ownership strategies. This study investigates the prerequisites for – and potential dissimilarities in the practice of, active ownership among...... institutional investors in two Scandinavian countries with diminutive legal and cultural distance in general. Research Findings/Insights: Using data on shareholder proposals from Danish and Swedish annual general meetings from 2006 throughout 2010, we find that institutional investors are approximately....../Policy Implications: Regulators should be aware of the impact by local governance mechanisms, and how shareholders react under different legal and practical prerequisites. The paper also highlights legal elements that differ between Denmark and Sweden, and which might affect institutional activism....

Institutional Repositories in Indian Universities and Research Institutes: A Study

Science.gov (United States)

Krishnamurthy, M.; Kemparaju, T. D.

2011-01-01

Purpose: The purpose of this paper is to report on a study of the institutional repositories (IRs) in use in Indian universities and research institutes. Design/methodology/approach: Repositories in various institutions in India were accessed and described in a standardised way. Findings: The 20 repositories studied covered collections of diverse…

What are Institutional Logics

DEFF Research Database (Denmark)

Berg Johansen, Christina; Waldorff, Susanne Boch

This study presents new insights into the explanatory power of the institutional logics perspective. With outset in a discussion of seminal theory texts, we identify two fundamental topics that frame institutional logics: overarching institutional orders guides by institutional logics, as well...... as change and agency generated by friction between logics. We use these topics as basis for an analysis of selected empirical papers, with the aim of understanding how institutional logics contribute to institutional theory at large, and which social matters institutional logics can and cannot explore...

23 years of the discovery of Helicobacter pylori: Is the debate over?

Directory of Open Access Journals (Sweden)

Ahmed Niyaz

2005-10-01

Full Text Available Abstract The Gram negative curved bacillus H. pylori has become the prize bug of all times. Barry Marshall and Robin Warren the two discoverers of this organism have been awarded with this year's Nobel Prize. The Nobel committee at the Karolinska Institute of Sweden has selected this paradigm shift discovery of 1982 as the most impacting in medical sciences. This award has surprised many as the Nobel assembly has selected this 'Robert Koch styled medical detective work' for the prize as compared to many outstanding basic research stories on the waitlist. This editorial briefly touches the significant impact of H. pylori on gastroduodenal management and the path forward as the bug has become quite controversial in recent times.

Institutional Repositories at Small Institutions in America: Some Current Trends

Science.gov (United States)

Nykanen, Melissa

2011-01-01

The research reported in this article was undertaken to determine the level of implementation of institutional repositories (IRs) at small institutions enrolling fewer than 10,000 students. The study analyzed quantitative and qualitative data from IRs at a number of small institutions with the aim of observing relevant patterns and trends that may…

TTI Phase 2 Institutional Support: Indian Institute of Dalit Studies ...

International Development Research Centre (IDRC) Digital Library (Canada)

This funding will enhance the Indian Institute of Dalit Studies' (IIDS) role as a credible public policy institution in India by strengthening its ability to provide high-quality, influential, and policy-relevant research. About the Indian Institute of Dalit Studies IIDS is a social sciences research centre with a focus on development ...

Institutional actorhood

DEFF Research Database (Denmark)

Madsen, Christian Uhrenholdt

In this paper I describe the changing role of intra-organizational experts in the face of institutional complexity of their field. I do this through a qualitative investigation of the institutional and organizational roles of actors in Danish organizations who are responsible for the efforts...... to comply with the Danish work environment regulation. And by doing so I also describe how institutional complexity and organizational responses to this complexity are particular important for the changing modes of governance that characterizes contemporary welfare states....

Bringing ideas back in to historical institutionalism to explain endogenous institutional change

DEFF Research Database (Denmark)

Carstensen, Martin B.; Schmidt, Vivien

The problem of how to theorize endogenous institutional change remains the ‘holy grail’ of historical institutionalism. Particularly important advances have been made within scholarship on gradual institutional transformation th at has deployed concepts like institutional ambiguity and interpreta...... in relation to two key issues: Interpretive battles over compliance and enforcement; and the role of ideas in forming, maintaining and changing the coalitions of actors that support a specific institutional setup....

North-South Institute Institutional Grant 2011-2012 | IDRC ...

International Development Research Centre (IDRC) Digital Library (Canada)

The North-South Institute (NSI) is an established independent thinktank in Canada whose work focuses on international development, poverty reduction and global inequalities. Building on a long history of collaboration between NSI and IDRC, this grant will provide the Institute with core support for 2011-2012. NSI activities ...

Institutional Support : African Institute for Applied Economics (AIAE ...

International Development Research Centre (IDRC) Digital Library (Canada)

The African Institute for Applied Economics (AIAE), Nigeria, is an independent policy research organization created in 2000. The Institute's mission is to promote evidence-based decision-making in the area of economic and social development. AIAE's strength is research and advocacy in the area of business environment, ...

Fred Forbats boksamling i Arkitekturmuseets bibliotek

OpenAIRE

Winka, Liselotte

2002-01-01

Fred Forbat (1897-1972) was born in Pécs, Hungary. He was educated as an architect in Budapest and Munich. After having finished his studies in 1920, Forbat was employed in Walter Gropius' architect's office at the Bauhaus in Weimar. Due to the political situation, Forbat decided to emigrate to Sweden in 1938. During the 1940s and 1950s he concentrated on urban planning, and was appointed Professor of Urban Planning at the Royal Institute of Technology in Stockholm in 1959. The Fred Forbat Bo...

Shallow water radio-magnetotelluric (RMT) measurements in urban environment: A case study from Stockholm city

Science.gov (United States)

Mehta, Suman; Bastani, Mehrdad; Malehmir, Alireza; Wang, Shunguo; Pedersen, Laust

2014-05-01

The Radio-MagnetoTelluric (RMT) method uses the electromagnetic signal from distant radio transmitters in the frequency range 15 to 250 kHz. RMT applications in near-surface studies have already been well established. Two components of electric field and three components of magnetic field are measured. These measured components are related to each other via transfer functions which contain detailed information about the variation of electrical resistivity of the subsurface. The present study is carried out in the frame of TRUST (TRansparent Underground STructure) project supported by several research and public organizations as well as industry. The study area is located close to central Stockholm in Sweden where the Swedish traffic authority has planned to construct a 21-km long motorway to bypass the city. In order to reduce the impact on natural and cultural environments, 18 km of the motorway will be located in tunnels. The main objective of this study is thus to identify potential fracture zones and faults as well as the general geological settings. The proposed path of the tunnel partly passes under the Lake Mälaren at a depth of about 60 m. Thus a challenge was posed on the applicability of RMT method in shallow water environments. Successful applications of RMT measurements using the Uppsala University's EnviroMT system on land encouraged us to modify the system to acquire data over lake water especially in urban areas. Pioneered by the Geological Survey of Sweden (SGU), RMT data were collected over the Lake Mälaren in spring 2012. The prototype acquisition system did not only turn out to be appropriate for such a challenging environment, but it was also much more efficient as compared with land surveys. Fifty two lines including 1160 stations with an average spacing of 15 m were covered in three days. Cultural noise associated with the city-related environment had to be identified and filtered out before inversion could be carried out. Reliable estimates

Stable or improved health status in the population 65 years and older in Stockholm, Sweden - an 8-year follow-up of self-reported health items.

Science.gov (United States)

Modig, Karin; Virtanen, Suvi; Ahlbom, Anders; Agahi, Neda

2016-07-01

Previous studies have reached different conclusions about whether health is improving in the ageing population. More studies with narrow age groups analyzed separately for men and women will contribute to the literature. To describe trends in self-reported indicators of health and health-related quality of life between 2002 and 2010, focusing on differences between gender and age groups. A population-based survey of individuals 65+ in the Stockholm County was used. Prevalence of health problems increased with age both among men and women. Men generally reported having no health problems to a larger extent than women, but the proportions reporting severe problems were similar. The larger picture is one of stability in health-related quality of life, even if several items developed for the better, especially among women. While the proportions reporting no health/functional problems increased for many items, the proportions reporting severe problems remained unchanged among men and improved only for two items among women. CONCLUSIONS OVERALL, IMPROVEMENTS WERE SEEN IN MANY OF THE HEALTH-RELATED QUALITY OF LIFE ITEMS AS WELL AS FOR SELF-RATED HEALTH AMONG WOMEN THE PROPORTIONS REPORTING LONG-TERM ILLNESS OR PERSISTENT HEALTH PROBLEMS INCREASED, BUT FEWER SEEM TO BE LIMITED IN THEIR DAILY ACTIVITIES BY THESE PROBLEMS THE STABLE PROPORTIONS OF POOR SELF-RATED HEALTH INDICATES THAT WHILE HEALTH AND FUNCTIONING SEEM TO BE IMPROVING FOR THE MAJORITY OF THE OLDER POPULATION, SOME GROUPS MAY BE LAGGING BEHIND FUTURE STUDIES SHOULD PAY ATTENTION TO CHANGES BOTH IN THE UPPER AND LOWER ENDS OF THE HEALTH SPECTRUM. © 2016 the Nordic Societies of Public Health.

The Medina Embolic Device: Karolinska experience.

Science.gov (United States)

Bhogal, P; Brouwer, P A; Yeo, L; Svensson, M; Söderman, M

2018-02-01

Background The aim of this study was to report our single centre experience with the Medina Embolic Device (MED). Methods We performed a retrospective analysis of prospectively collected data to identify all patients treated with the MED. A total of 14 aneurysms (non-consecutive), in 13 patients, were treated including one ruptured and one partially thrombosed aneurysm. Fundus diameter was ≥5 mm in all cases. We evaluated the angiographic appearances, the clinical status, complications, and the need for adjunctive devices or repeat treatments. Results Aneurysm location was cavernous internal carotid artery (ICA; n = 1), supraclinoid ICA ( n = 1), terminal ICA ( n = 2), anterior communicating artery (AComA; n = 4), A2-3 ( n = 1), M1-2 junction ( n = 1), posterior communicating artery (PComA; n = 1), superior cerebellar artery (SCA; n = 1), and basilar tip ( n = 2). The average aneurysm fundus size was 8.6 mm (range 7-10 mm) and average neck size 3.75 mm (range 1.9-6.9 mm). Immediate angiographic results were modified Raymond-Roy occlusion classification (mRRC) I n = 2, mRRC II n = 1, mRRC IIIa n = 2, mRRC IIIb n = 2, the remaining 7 aneurysms showed complete opacification. At follow-up angiography (mean 5 months) mRRC I n = 5, mRRC II n = 5, mRRC IIIa n = 3, and persistent filling was seen in 1 aneurysm. Overall, four patients had repeat treatment and one is pending further treatment. Of the aneurysms treated with more than one MED, 75% showed complete occlusion at 6-month follow up whereas only one aneurysm treated with a single device showed complete occlusion. Overall, three patients had temporary complications and there were no deaths. Conclusions The MED is an intra-saccular flow-diverting device with satisfactory angiographic results and an acceptable safety profile. Use of a single MED cannot be recommended and further longer term studies are needed prior to widespread clinical use.

INFLUENCE OF RELATIONS WITH INTERNATIONAL FINANCIAL INSTITUTIONS ON INSTITUTIONAL TRANSFORMATIONS OF ECONOMY

Directory of Open Access Journals (Sweden)

Galyna POCHENCHUK

2014-12-01

Full Text Available The article deals with the problem of the impact of transitional countries cooperation with international financial institutions on institutional changes which take place in emerging market economies, on the base of Ukraine. Research is carried out from the standpoint of institutional theory. The main reforms that took place in emerging market economy countries were based on the Washington Consensus strategy recommended by international financial institutions. The results of implementing this strategy are varied in different countries. In Ukraine strict adherence to requirements in the early stages of reforms without internal institutional conditions and characteristics led to a deep and protracted crisis of forming a "transformational stability." The general formal institutions of the market economy have been created according to the neoliberal concept which is provided by IFIs. However, experience of transitive economies including Ukraine, confirms the ineffectiveness of many established formal institutions borrowed from the developed countries. The author reviews the basic theory of institutional changes, argues that the terms of cooperation circulated by international financial institutions not only affect economic development strategy, but also determine the role of the national government in relations with markets. Under present conditions prevailing in Ukraine, it is impossible to manage without assistance of international financial institutions. But we need to pay more attention to technical and advisory cooperation in realization of institutional reforms, and credits – to take as a required time for receiving the results of reforms.

Institutional Logics in Action

DEFF Research Database (Denmark)

Lounsbury, Michael; Boxenbaum, Eva

2013-01-01

This double volume presents state-of-the-art research and thinking on the dynamics of actors and institutional logics. In the introduction, we briefly sketch the roots and branches of institutional logics scholarship before turning to the new buds of research on the topic of how actors engage...... institutional logics in the course of their organizational practice. We introduce an exciting line of new works on the meta-theoretical foundations of logics, institutional logic processes, and institutional complexity and organizational responses. Collectively, the papers in this volume advance the very...... prolific stream of research on institutional logics by deepening our insight into the active use of institutional logics in organizational action and interaction, including the institutional effects of such (inter)actions....

Unintentional formation and emission of the persistent organic pollutants HCB and PCBs in the Nordic countries. Documentation of existing information regarding sources and emissions to air, water and soil, with focus on reporting obligations according to the Stockholm Convention, the UNECE POP protocol, and PRTR registers

Energy Technology Data Exchange (ETDEWEB)

2009-07-01

In recent years reporting requirements regarding emissions and releases of unintentionally formed persistent organic pollutants (POPs) have been laid on parties to international agreements and members of the EU. Such obligations include those under the Stockholm Convention on Persistent Organic Pollutants, the UNECE POP and PRTR protocols and the EU PRTR regulation. The aim of this project has been to assess, whether existing knowledge and data are adequate for the Nordic countries to be able to estimate the emissions eventually to be reported. The project reveals that there is a substantial lack of knowledge related to potential sources in the Nordic countries. It also suggests that even though many of the main potential sources are the same, the relative importance of them differs between countries. (au)

Institutions as Knowledge Capital

DEFF Research Database (Denmark)

Foss, Nicolai Juul; Garzarelli, Giampaolo

The paper revisits the socioeconomic theory of the Austrian School economist Ludwig M. Lachmann. By showing that the common claim that Lachmann's idiosyncratic (read: eclectic and multidisciplinary) approach to economics entails nihilism is unfounded, it reaches the following conclusions. (1......) Lachmann held a sophisticated institutional position to economics that anticipated developments in contemporary new institutional economics. (2) Lachmann's sociological and economic reading of institutions offers insights for the problem of coordination. (3) Lachmann extends contemporary new institutional...... theory without simultaneously denying the policy approach of comparative institutional analysis. (90 words.)KeywordsComparative institutional analysis, coordination, expectations, institutionalevolution, interpretative institutionalism.JEL CodesB31, B52, B53, D80....

Screening for germline phosphatase and tensin homolog-mutations in suspected Cowden syndrome and Cowden syndrome-like families among uterine cancer patients

Science.gov (United States)

TZORTZATOS, GERASIMOS; ARAVIDIS, CHRISTOS; LINDBLOM, ANNIKA; MINTS, MIRIAM; THAM, EMMA

2015-01-01

Cowden syndrome (CS) is an autosomal dominant disorder characterized by multiple hamartomas in the breast, thyroid and endometrium, with a prevalence of 1 per 250,000. Females with CS have a 21–28% lifetime risk of developing uterine cancer. Germline mutations in the phosphatase and tensin homolog (PTEN) gene, a tumor suppressor gene, are responsible for 30–80% of CS cases. PTEN is a nine-exon gene, located on chromosome 10q23.3, which encodes the 403 amino acid PTEN protein. It negatively regulates the phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin pathway, affecting various cellular processes and signaling pathways. The present study examined whether PTEN mutations are present in CS-like families with uterine cancer (UC). UC patients underwent surgery at Karolinska University Hospital, Stockholm, Sweden (2008–2012). Pedigrees were analyzed and 54 unrelated CS-like families were identified. CS-like families were defined as having at least one occurrence of uterine cancer and one of breast cancer, as well as at least one additional Cowden-associated tumor (uterine, breast, thyroid, colon or kidney cancer) in the same individual or in first-degree relatives. Genomic DNA was amplified using polymerase chain reaction, and DNA sequencing analysis of all nine exons of the PTEN gene was conducted. No germline PTEN mutations or polymorphisms were identified. Germline PTEN mutations are rare in CS-like families with uterine cancer, therefore, genetic screening must be restricted to patients that meet the strict National Comprehensive Cancer Network criteria. Gynecologists must be aware of the CS criteria and identify potential cases of CS in females where uterine cancer is the sentinel cancer. PMID:25789042

Pad use and patient reported bother from urinary leakage after radical prostatectomy.

Science.gov (United States)

Wallerstedt, Anna; Carlsson, Stefan; Nilsson, Andreas E; Johansson, Eva; Nyberg, Tommy; Steineck, Gunnar; Wiklund, N Peter

2012-01-01

To better understand clinically significant definitions of urinary incontinence we investigated the relationship between urinary leakage and patient reported bother from urinary leakage. A consecutive series of 1,411 men who underwent radical prostatectomy at Karolinska University Hospital, Stockholm, Sweden, from 2002 to 2006 were invited to complete a study specific questionnaire with questions on pad status, urinary leakage and bother from urinary leakage. Questionnaires were received from 1,179 men with a followup of greater than 1 year (median 2.2). Results showed that even a small amount of urinary leakage resulted in a high risk of urinary bother. Of 775 survivors 46 (6%) reporting 0 pads indicated moderate or much bother compared to 38 of 123 (31%) who reported using a security pad. When comparing the 2 groups, the risk of bother from urinary leakage was more than 5 times higher in the safety pad vs the 0 pad group (RR 5.2, 95% CI 3.5-7.7). As the number of pads increased, we noted a higher bother risk. Cross-tabulation of pad use and urinary leakage revealed wide variation in pad requirements despite the same answer to urinary leakage questions. If the definition of continence is based on pad use, for example safety pads, a certain number of men who report moderate or much bother from urinary leakage will be defined as continent. Our results also show that for each stated rate of urinary leakage men prove to have a major variation in the pad requirement. Copyright © 2012 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

Stereotactic radiosurgery in acoustic neurinomas

Energy Technology Data Exchange (ETDEWEB)

Yamamoto, Masaaki; Noren, G. (Karolinska Hospital, Stockholm (Sweden))

1990-12-01

The records of 57 patients with 61 acoustic neurinomas treated with stereotatic radiosurgery at the Karolinska Hospital, Stockholm, from 1982 through 1984, were reviewed. Adequate radiological and clinical follow-up evaluations were available in these cases. An additional 8 patients were treated during this same period but were not included because of insufficient data. The tumors were evaluated with CT or MRI. Their post-operative follow-up period was 6-66 months (mean 28 months). Decrease of tumor size or no change was considered as a response to radiosurgery. This was found in 54 (88%) of the tumors. Small tumors with a diameter of less than 15 mm responded better (93%) than large ones (85%). Ninety-five percent of unilateral tumors and 74% of tumors associated with neurofibromatosis responded well. Seven tumors had definite radiographic signs of subsequent growth. Four were removed using standard microsurgical tequniques and three have so far not required further treatment. Facial and trigeminal nerve function was evaluated in 58 facial surfaces where tumors had been irradiated. Transient facial weakness developed in 9% and facial hypesthesia in 9% of the irradiated cases. The onset of these nerve dysfunction appeared with a latency period of 4 to 15 months after radiosurgery. Excluding the ears which had been totally deaf before the treatment, forty-one ears were evaluated fully by audiometry prior to and one year after irradiation. 30% of them had no change in hearing, 68% had a more or less pronouced deterioration and 2% had improvement. We regard efficiency in arresting tumor growth without endangering life, preservation of facial nerve function, and only a day of hospitalization as major benefits of radiosurgery. (author).


Intrathecal analgesia by bupivacaine is not enhanced by coadministration of morphine in patients with severe cancer-related pain: a randomized double-blind cross-over study.

Science.gov (United States)

Reif, Ingalill; Wincent, Anders; Stiller, Carl-Olav

2017-06-01

The objective of this randomized double blind cross-over trial was to determine if patients with severe cancer-related pain and inadequate response to systemic opioids prefer intrathecal (IT) pain relief with a combination of bupivacaine and morphine or bupivacaine only. Adult patients with cancer-related pain (n = 23) scheduled for IT analgesia at the Pain Center at the Karo-linska University Hospital Solna, Stockholm, Sweden, were included. The optimal individual flow rate of IT bupivacaine (2 mg/mL) in addition to bolus doses was titrated and maintained for 4 days. Morphine (1 mg/mL) was added to bupivacaine either on day 2 or 4 according to a randomization protocol. Expression of pain relief preference for morphine instead of control (bupivacaine only) was the primary outcome. Secondary outcomes were difference in pain intensity, pain relief, total use of bupivacaine per 24 hours and number of requested bolus doses. Eight patients dropped out during the 4-day study period for reasons not related to the trial. IT bupivacaine significantly decreased median (interquartile range) pain intensity from 5 (3 - 7) at baseline (before catheter insertion) to 1 (0 - 1) (p = 0.0001; Wilcoxon test). Only 1 patient of 15 with 4-day data expressed any preference for morphine. The addition of IT morphine did not result in any significant change of pain intensity, pain relief score, total use of bupivacaine per 24 hours, or number of requested bolus doses. These results suggest that patients with cancer-related pain treated with high doses of systemic opioids, may start IT treatment with an optimal dose of IT bupivacaine without morphine.
.

Emergency contraception: potential role of ulipristal acetate

Directory of Open Access Journals (Sweden)

Kristina Gemzell-Danielsson

2010-04-01

Full Text Available Kristina Gemzell-Danielsson, Chun-Xia MengDepartment of Women’s and Children’s Health, Division of Obstetrics and Gynecology, Karolinska Institutet, Stockholm, SwedenAbstract: Unintended pregnancy is a global reproductive health problem. Emergency contraception (EC provides women with a safe means of preventing unwanted pregnancies after having unprotected intercourse. While 1.5 mg of levonorgestrel (LNG as a single dose or in 2 doses with 12 hours apart is the currently gold standard EC regimen, a single dose of 30 mg ulipristal acetate (UPA has recently been proposed for EC use up to 120 hours of unprotected intercourse with similar side effect profiles as LNG. The main mechanism of action of both LNG and UPA for EC is delaying or inhibiting ovulation. However, the ‘window of effect’ for LNG EC seems to be rather narrow, beginning after selection of the dominant follicular and ending when luteinizing hormone peak begins to rise, whereas UPA appears to have a direct inhibitory effect on follicular rupture which allows it to be also effective even when administered shortly before ovulation, a time period when use of LNG is no longer effective. These experimental findings are in line with results from a series of clinical trials conducted recently which demonstrate that UPA seems to have higher EC efficacy compared to LNG. This review summarizes some of the data available on UPA used after unprotected intercourse with the purpose to provide evidence that UPA, a new type of second-generation progesterone receptor modulator, represents a new evolutionary step in EC treatment.Keywords: emergency contraception, ulipristal acetate, levonorgestrel

Entrepreneurship as institutional change

DEFF Research Database (Denmark)

Bjerregaard, Toke; Lauring, Jakob

2012-01-01

This paper responds to calls to make more explicit linkages between institutional theory and entrepreneurship research through studies on how entrepreneurs navigate and work with institutions. The research examines the micro-strategies and activities through which small-scale entrepreneurs maneuver...... between and exploit the multiple, potentially contradictory institutional logics of the different spheres in which they operate. While much research has elucidated how institutional entrepreneurs effect change, this study illustrates how effective entrepreneurs managing and exploiting institutional...... contradictions engage simultaneously in practices of maintaining and changing institutions to establish a balance between the poles on which their ventures depend. We illustrate this by two cases of small-scale entrepreneurship bridging institutional contradictions from an ethnographic study conducted under...

Colonial Institutions

DEFF Research Database (Denmark)

McAtackney, Laura; Palmer, Russell

2016-01-01

and the USA which reveal that the study of colonial institutions should not be limited to the functional life of these institutions—or solely those that take the form of monumental architecture—but should include the long shadow of “imperial debris” (Stoler 2008) and immaterial institutions....

What are Institutional Logics

OpenAIRE

Berg Johansen, Christina; Bock Waldorff, Susanne

2015-01-01

This study presents new insights into the explanatory power of the institutional logics perspective. With outset in a discussion of seminal theory texts, we identify two fundamental topics that frame institutional logics: overarching institutional orders guided by institutional logics, as well as change and agency generated by friction between logics. We use these topics as basis for an analysis of selected empirical papers, with the aim of understanding how institutional logics contribute to...

Institutional Logics in Inter-institutional Temporary Organizations

DEFF Research Database (Denmark)

Pemsel, Sofia; Söderlund, Jonas

-cognitive, normative, and regulative – are unfolding and evolving in such contexts. The case study addresses the integration and disintegration of logics and normative orders in an ongoing process characterized by the co-mingling, co-existence, creation and resolutions of hybrid logics and creation of institutional...... exceptions throughout the life of the studied temporary organization. In that respect, this paper contributes with a more nuanced view on the evolution, dynamics, and co-existence of pressures from multiple institutional demands at the organizational level....

Institutional transformation: An analysis of change initiatives at NSF ADVANCE institutions

Science.gov (United States)

Plummer, Ellen W.

The purpose of this study was to examine how institutional culture promoted or impeded the implementation of round one and two NSF ADVANCE initiatives designed to improve academic climates for women in science and engineering. This study was conducted in two phases. In phase one, 35 participants from 18 institutions were interviewed to answer three research questions. Participants identified a policy, process, or program designed to improve academic cultures for women in science and engineering fields. Participants also identified strategies that promoted the implementation of these efforts, and discussed factors that impeded these efforts. In phase two, site visits were conducted at two institutions to answer a fourth research question. How did institutional culture shape the design and implementation of faculty search processes? Policies, processes, and programs were implemented by participants at the institutional, departmental, and individual levels and included family friendly and dual career policies at the institutional level, improved departmental faculty search and climate improvement processes, and mentoring programs and training for department heads at the individual level. Communication and leadership strategies were key to the successful implementation of policies, processes, and programs designed to achieve institutional transformation. Communication strategies involved shaping change messages to reach varied audiences often with the argument that change efforts would improve the climate for everyone not just women faculty members. Administrative and faculty leaders from multiple levels proved important to change efforts. Institutional Transformation Institutional culture shaped initiatives to improve faculty search processes. Faculty leaders in both settings used data to persuade faculty members of the need for change. At one site, data that included national availability information was critical to advancing the change agenda. At the other site

In vitro pharmacological characterization of a novel TRPA1 antagonist and proof of mechanism in a human dental pulp model

Directory of Open Access Journals (Sweden)

Nyman E

2013-01-01

Full Text Available Eva Nyman,1,* Bo Franzén,1,* Andreas Nolting,1 Göran Klement,1 Gang Liu,1 Maria Nilsson,1 Annika Rosén,2 Charlotta Björk,3 Dirk Weigelt,4 Patrik Wollberg,1 Paul Karila,1 Patrick Raboisson11Neuroscience, Innovative Medicines CNS/Pain, AstraZeneca R&D, Södertälje, Sweden; 2Division of Oral and Maxillofacial Surgery, Karolinska Institute/Karolinska University Hospital, Huddinge, Sweden; 3Clinical TA NS Early Development, 4Medicinal Chemistry, Innovative Medicines CNS/Pain, AstraZeneca R&D, Södertälje, Sweden*These authors contributed equally to this workAbstract: AZ465 is a novel selective transient receptor potential cation channel, member A1 (TRPA1 antagonist identified during a focused drug discovery effort. In vitro, AZ465 fully inhibits activation by zinc, O-chlorobenzylidene malononitrile (CS, or cinnamaldehyde of the human TRPA1 channel heterologously expressed in human embryonic kidney cells. Our data using patch-clamp recordings and mouse/human TRPA1 chimeras suggest that AZ465 binds reversibly in the pore region of the human TRPA1 channel. Finally, in an ex vivo model measuring TRPA1 agonist-stimulated release of neuropeptides from human dental pulp biopsies, AZD465 was able to block 50%–60% of CS-induced calcitonin gene-related peptide release, confirming that AZ465 inhibits the native human TRPA1 channel in neuronal tissue.Keywords: pain, pharmacology, antagonist, chimeric proteins, dental pulp, inflammation, neuropeptide, calcitonin gene-related peptide, CGRP

Renewable energy prospects for implementation

CERN Document Server

Jackson, Tim

1993-01-01

Renewable Energy: Prospects for Implementation contains papers that were originally commissioned by the journal Energy Policy for a series on renewable energy appearing between January 1991 to September 1992. In view of the fast-changing demands on conventional energy supply to meet environmental imperatives, it seemed timely to reproduce here a selection of those papers with a new introduction and a revised concluding chapter by the Editor of the series, Dr Tim Jackson, a research fellow with the Stockholm Environment Institute. The book is organized into four parts. The papers in Part I

Motor fuels made by direct liquefaction of coal, peat and biomass. Drivmedel genom direktfoervaetskning av kol, torv och biomassa

Energy Technology Data Exchange (ETDEWEB)

Granath, L; Karlsson, G; Karlsson, G; Nilsson, T

1981-01-01

The Department of Chemical Technology at the Royal Institute of Technology has completed a system study concerning direct liquefaction of peat and biomass to produce transportation fuel. A comprehensive survey of coal liquefaction is included. Gasoline produced in Sweden from direct liquefaction of imported coal may compete with regular gasoline at the earliest around 1985. Biomass can become a competitive alternative to black coal at the beginning of the 21st century. Methanol can be produced from wood with a higher efficiency than the transportation fuels which are produced by direct liquefaction. The peat is not good source for liquefaction as wood chips. A continuously working liquefaction plant designed also for peat among other substances is under construction at the Royal Institute of Technology, Stockholm.

North-South Institute Institutional Grant 2011-2012 | CRDI - Centre ...

International Development Research Centre (IDRC) Digital Library (Canada)

The North-South Institute (NSI) is an established independent thinktank in Canada whose work focuses on international development, poverty reduction and global inequalities. Building on a long history of collaboration between NSI and IDRC, this grant will provide the Institute with core support for 2011-2012. NSI activities ...

Painting for freedom

DEFF Research Database (Denmark)

Watts, Miriam

2011-01-01

Udstillingsanmeldelse af ’The Peredvizhniki: Pioneers of Russian Painting’, Nationalmuseum Stockholm 2011-2012 og Kunstsammlungen Chemnitz 2012.......Udstillingsanmeldelse af ’The Peredvizhniki: Pioneers of Russian Painting’, Nationalmuseum Stockholm 2011-2012 og Kunstsammlungen Chemnitz 2012....

Coevolution of economic behaviour and institutions: towards a theory of institutional change

NARCIS (Netherlands)

van den Bergh, J.C.J.M.

2003-01-01

Traditionally, economics has regarded institutions, notably norms and regulations, as fixed or exogenous. Surprisingly few insights on institutional evolution from natural and social sciences have made their way into economics. This article gives an overview of evolutionary theories of institutions

Strengthening Institutions to Legitimise Business Continuity in Weak Institutional Environments

DEFF Research Database (Denmark)

Taarup Esbensen, Jacob

This paper investigates how weak institutional environments influence MNE decision making to be involved in creating public good facilities with the aim of reducing community risk, and to what extend these can be traced back to the MNE choose of a Head Quarter (HQ) or local embeddedness driven...... in their dealings with local communities. One strategy is based on rules provide by the HQ, which focuses on providing guidelines in compliance with normative global institutions, while another strategy focuses on embedding the subsidiary in the local institutional environment. Both of these strategies aim...... public good facilities in the absence or at best weak institutional environment. Secondly, serving as an effective risk mitigation tool that keeps aggressive actors from partnering with local communities against the company thereby presenting a risk to its continued operations....

Institutional Support : Kenya Institute for Public Policy Research and ...

International Development Research Centre (IDRC) Digital Library (Canada)

In 2006 the Government of Kenya passed an Act of Parliament making the Kenya Institute for Public Policy Research and Analysis (KIPPRA) the government's lead socioeconomic research institute. The Act exerts enormous demands on KIPPRA at a time when it is trying to recover from the senior staff turnover suffered in ...

Institutional And Non-Institutional Credit Supply Services To Fisher ...

African Journals Online (AJOL)

Women in the study area prefer the informal, non institutional credit sources than the formal, institutional source as the poor fisher-folk require collateral for this which in most cases was not available. From the study, adequate finance with more relax conditions will go a long way in alleviating poverty and improving ...

Sodomie, gender studies und die baltische Geschichte : Anmerkungen zu einer schwedischen Dissertation / Aivar Põldvee

Index Scriptorium Estoniae

Põldvee, Aivar, 1962-

2013-01-01

Arvustus: Sjödin Lindenskoug, Susanna. Manlighetens bortre gräns : tidelagsrättegångar i Livland åren 1685-1709. (Stockholms Studie in history, 94 ; Södertörn doctoral dissertations, 55). Stockholm, 2011

A protocol of rehabilitation after ACL reconstruction using a hamstring autograft in the first month after surgery--a preliminary report.

Science.gov (United States)

Biernat, Ryszard; Wołosewicz, Mariusz; Tomaszewski, Wiesław

2007-01-01

The purpose of this paper is to present a protocol of rehabilitation after ACL reconstruction using a hamstring autograft in the first month after surgery. The program enables the patient to return early to everyday activities (school, sedentary work) without crutches or a stabilizer. The program has been developed in accordance with rehabilitation protocols employed at Karolinska Institute in Sweden and Prof. Shelbourne's Clinic in the USA. The study group included 31 patients (18 men and 13 women). Patients rehabilitated in the Department according to our program achieved stable gait patterns and were able to step up and down within four to seven weeks. Early patient mobilization after ACL reconstruction is possible and does not cause any negative effects provided that the patient, doctor and physiotherapist cooperate very closely.

Institutions, Anomie, and Violent Crime: Clarifying and Elaborating Institutional-Anomie Theory

Directory of Open Access Journals (Sweden)

Richard Rosenfeld

2008-11-01

Full Text Available A limited but accumulating body of research and theoretical commentary offers support for core claims of the “institutional-anomie theory” of crime (IAT and points to areas needing further development. In this paper, which focuses on violent crime, we clarify the concept of social institutions, elaborate the cultural component of IAT, derive implications for individual behavior, summarize empirical applications, and propose directions for future research. Drawing on Talcott Parsons, we distinguish the “subjective” and “objective” dimensions of institutional dynamics and discuss their interrelationship. We elaborate on the theory’s cultural component with reference to Durkheim’s distinction between “moral” and “egoistic” individualism and propose that a version of the egoistic type characterizes societies in which the economy dominates the institutional structure, anomie is rampant, and levels of violent crime are high. We also offer a heuristic model of IAT that integrates macro- and individual levels of analysis. Finally, we discuss briefly issues for the further theoretical elaboration of this macro-social perspective on violent crime. Specifically, we call attention to the important tasks of explaining the emergence of economic dominance in the institutional balance of power and of formulating an institutional account for distinctive punishment practices, such as the advent of mass incarceration in the United States.

Institution Morphisms

Science.gov (United States)

Goguen, Joseph; Rosu, Grigore; Norvig, Peter (Technical Monitor)

2001-01-01

Institutions formalize the intuitive notion of logical system, including both syntax and semantics. A surprising number of different notions of morphisim have been suggested for forming categories with institutions as objects, and a surprising variety of names have been proposed for them. One goal of this paper is to suggest a terminology that is both uniform and informative to replace the current rather chaotic nomenclature. Another goal is to investigate the properties and interrelations of these notions. Following brief expositions of indexed categories, twisted relations, and Kan extensions, we demonstrate and then exploit the duality between institution morphisms in the original sense of Goguen and Burstall, and the 'plain maps' of Meseguer, obtaining simple uniform proofs of completeness and cocompleteness for both resulting categories; because of this duality, we prefer the name 'comorphism' over 'plain map.' We next consider 'theoroidal' morphisms and comorphisims, which generalize signatures to theories, finding that the 'maps' of Meseguer are theoroidal comorphisms, while theoroidal morphisms are a new concept. We then introduce 'forward' and 'semi-natural' morphisms, and appendices discuss institutions for hidden algebra, universal algebra, partial equational logic, and a variant of order sorted algebra supporting partiality.

Lighting detectives forum

DEFF Research Database (Denmark)

Bülow, Katja; Skindbjerg Kristensen, Lisbeth

2003-01-01

Belysning for boligområder var emnet for lighting detectives forum, der blev afholdt i Stockholm i august 2003.......Belysning for boligområder var emnet for lighting detectives forum, der blev afholdt i Stockholm i august 2003....

Treatment outcomes after initiation of exenatide twice daily or insulin in clinical practice: 12-month results from CHOICE in six European countries

Directory of Open Access Journals (Sweden)

Ostenson CG

2013-04-01

Full Text Available Claes-Göran Östenson,1 Stephan Matthaei,2 Matthew Reaney,3 Thure Krarup,4 Bruno Guerci,5 Jacek Kiljanski,6 Carole Salaun-Martin,7 Hélène Sapin,7 David Bruhn,8 Chantal Mathieu,9 Michael Theodorakis10 1Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden; 2Diabetes-Center Quakenbrück, Quakenbrück, Germany; 3Eli Lilly, Windlesham, Surrey, UK; 4Department of Endocrinology I, Bispebjerg Hospital, Copenhagen, Denmark; 5Diabetology, Metabolic Diseases and Nutrition, Brabois Hospital, CHU Nancy, and INSERM CIC, ILCV, Vandoeuvre Lès Nancy, France; 6Eli Lilly, Warsaw, Poland; 7Eli Lilly, Neuilly Cedex, France; 8Eli Lilly, San Diego, California, USA; 9Department of Endocrinology, UZ Gasthuisberg, Leuven, Belgium; 10Department of Clinical Therapeutics, University of Athens School of Medicine, Athens, Greece* *Michael Theodorakis was affiliated with the institution shown at the time of the study, but has since left this institution Objective: The CHanges to treatment and Outcomes in patients with type 2 diabetes initiating InjeCtablE therapy (CHOICE study assessed time to, and reasons for, significant treatment change after patients with type 2 diabetes (T2DM initiated their first injectable glucose-lowering therapy (exenatide twice daily [BID] or insulin in routine clinical practice, and these patients’ clinical outcomes, in six European countries. This paper reports interim data from the first 12 months of the study. Research design and methods: CHOICE (NCT00635492 is a prospective, noninterventional, observational study. Clinical data were collected at initiation of first injectable therapy and after approximately 3, 6, and 12 months. Results: Of 2497 patients enrolled in CHOICE, 1096 in the exenatide BID and 1239 in the insulin cohorts had ≥1 post-baseline assessment and were included in this analysis. Overall, 32.2% of the exenatide BID cohort and 29.1% of the insulin cohort (Kaplan–Meier estimates had

John Searle on Institutional Facts

Directory of Open Access Journals (Sweden)

m Abdullahi

2010-09-01

Here we argue that the essence of institutional facts is status functions. Humans recognize these functions which contain a set of deontic powers through collective intentionality. Therefore, institutional facts are ontologically subjective and epistemologically objective. Nevertheless, objectivity of institutional facts totally depends on language which itself is a fundamental institution for other institutions.

Relationships Between Culture and Institutions

DEFF Research Database (Denmark)

Schultz, Majken

2012-01-01

This article suggests four different relationships between institutionalism and organizational culture seen as two different levels of analysis. The relationships represent a continuum from a significant influence of the institutional level on organizational culture to a significant cultural...... influence on the formation and construction of institutions. The four relationships are defined as 1) cultural filtering of institutional pressure from isomorphism, 2) organizational culture as a source of new institutional elements, 3) organizational culture as a source of positioning towards institutions...... the relationships between culture and institutions and how they are connected. Finally, the article points at the influence of globalization challenging the national origin of many institutions when relating to a world of organizations, which increasingly are becoming global. For some companies, organizational...

Parkinson’s disease patients’ subjective descriptions of characteristics of chronic pain, sleeping patterns and health-related quality of life

Directory of Open Access Journals (Sweden)

Skogar Ö

2012-10-01

Full Text Available Örjan Skogar,1,5 Per-Arne Fall,2 Gunnar Hallgren,3 Birgitta Bringer,2 Miriam Carlsson,1 Ulla Lennartsson,3 Håkan Sandbjörk,3 Carl-Johan Törnhage,4 Johan Lökk51Department of Geriatrics, Ryhov Hospital, Jonkoping, Sweden; 2Department of Geriatrics, University Hospital, Linkoping, Sweden; 3Department of Neurology, 4Department of Pediatrics, Skaraborg Hospital, Skövde, Sweden; 5Institution of Neurobiology, Karolinska Institutet, Stockholm, SwedenObjective: Nonmotor symptoms are common in Parkinson’s disease (PD. Health-related quality of life (HRQoL is negatively affected by different factors, of which pain and sleep disturbances are important contributors. This study was performed to evaluate and describe subjective experiences of pain, sleeping patterns, and HRQoL in a cohort of PD patients with chronic pain.Methods: A total of 45 participants with established PD for more than 2 years, and PD-related pain for the preceding three months, were recruited from three sites in Sweden. Data regarding time point for onset, duration and degree of pain parameters, body localization of pain, external influences, and treatments were obtained. HRQoL was evaluated with the Short Form-36® Health Survey, and sleeping patterns were registered with the Parkinson’s disease Sleep Scale, both completed along with a questionnaire.Results: In one-third of participants, pain preceded the PD diagnosis. Median pain score measured with a visual analog scale was 6.6 and 5.9 (for females and males, respectively the week before the study. In almost half of the participants, pain was present during all their waking hours. Significantly more females described their pain as troublesome, while more males described their pain as irritating. Feelings of numbness and creeping sensations at night were strongly associated with the maximal visual analog scale scores. Polypharmacy was common; 89% used medication for anxiety/insomnia, and 18% used antidepressants. Only one

Birth weight, sex, and celiac disease: a nationwide twin study

Directory of Open Access Journals (Sweden)

Kuja-Halkola R

2017-11-01

Full Text Available Ralf Kuja-Halkola,1 Benjamin Lebwohl,1,2 Jonas Halfvarson,3 Louise Emilsson,4–6 Patrik K Magnusson,1 Jonas F Ludvigsson1,2,7,8 1Department Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; 2Department of Medicine, Celiac Disease Center, Columbia University Medical Center, Columbia University, New York, NY, USA; 3Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden; 4Department of Health Management and Health Economy, Institute of Health and Society, University of Oslo, Oslo, Norway; 5Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; 6Centre for Clinical Research, Vårdcentralen Värmlands Nysäter, County Council of Värmland, Värmland, 7Department of Pediatrics, Örebro University Hospital, Örebro, Sweden; 8Division of Epidemiology and Public Health, School of Medicine, City Hospital, University of Nottingham, Nottingham, UK Objective: Earlier research suggests that birth weight may be associated with celiac disease (CD, but the direction of association has been unclear potentially due to confounding effect from genetic and intrafamilial factors. Through within-twin analyses, we aimed to minimize confounding effects such as twins that share genetic and early environmental exposures.Materials and methods: Using the Swedish Twin Registry, we examined the birth weight of 146,830 twins according to the CD status. CD was defined as having villous atrophy according to a small intestinal biopsy reports.Results: The prevalence of diagnosed CD was 0.5% (n=669, and we included 407 discordant pairs of CD–non-CD twins. Comparing the 669 CD patients with non-CD twins, the association between birth weight and future CD was not statistically significant (odds ratio [OR] per 1000 g increase in birth weight: 1.16; 95% confidence interval [CI]=0.97–1.38. In males, the association was positive and statistically significant (OR=1.50; 95% CI

NUCOR Institute for Life Sciences

International Nuclear Information System (INIS)

Anon.

1984-01-01

The article discusses the Nucor Institute for Life Sciences. The institute was previously part of Nucor, but is now an autonomous institute of the University of Pretoria. The task of the institute is to promote the application of radioisotopes and radiation techniques in medicine and biology. Research projects of the institute are shortly discussed

Measures of bronchodilator response of FEV1, FVC and SVC in a Swedish general population sample aged 50–64 years, the SCAPIS Pilot Study

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Torén K

2017-03-01

Full Text Available K Torén,1 B Bake,1 A-C Olin,1 G Engström,2 A Blomberg,3 J Vikgren,4 J Hedner,5 J Brandberg,4 HL Persson,6,7 CM Sköld,8 A Rosengren,9 G Bergström,9 C Janson10 1Section of Occupational and Environmental Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, 2Department of Clinical Science, Lund University, Malmö, 3Division of Medicine/Respiratory Medicine, Department of Public Health and Clinical Medicine, Umeå University, Umeå, 4Department of Radiology, Institute of Clinical Sciences, 5Department of Internal Medicine/Lung Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, 6Department of Respiratory Medicine, 7Department of Medicine and Health Sciences, Linköping University, Linköping, 8Respiratory Medicine Unit, Department of Medicine Solna, Centre for Molecular Medicine, Karolinska Institutet, Stockholm, 9Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, 10Department of Medical Sciences, Clinical Physiology and Lung, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden Background: Data are lacking from general population studies on how to define changes in lung function after bronchodilation. This study aimed to analyze different measures of bronchodilator response of forced expiratory volume in 1 second (FEV1, forced vital capacity (FVC and slow vital capacity (SVC. Materials and methods: Data were derived from the Swedish Cardiopulmonary Bioimage Study (SCAPIS Pilot study. This analysis comprised 1,050 participants aged 50–64 years from the general population. Participants were investigated using a questionnaire, and FEV1, FVC and SVC were recorded before and 15 minutes after inhalation of 400 µg of salbutamol. A bronchodilator response was defined as the relative change from baseline value expressed as the difference in units of percent predicted normal

Canadian institute honours Hawking

Science.gov (United States)

Durrani, Matin

2009-11-01

The Perimeter Institute for Theoretical Physics in Waterloo, Canada, has announced that a major new extension to its campus will be known as the Stephen Hawking Centre. The extension, which is currently being built, is due to open in 2011 and will double the size of the institute. It will also provide a home for the institute's Masters students, the first of whom joined the Perimeter Institute this autumn as part of its Perimeter Scholars international programme.

Institution, Financial Sector, and Economic Growth: Use The Institutions As An Instrument Variable

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Albertus Girik Allo

2016-06-01

Full Text Available Institution has been investigated having indirect role on economic growth. This paper aims to evaluate whether the quality of institution matters for economic growth. By applying institution as instrumental variable at Foreign Direct Investment (FDI, quality of institution significantly influence economic growth. This study applies two set of data period, namely 1985-2013 and 2000-2013, available online in the World Bank (WB. The first data set, 1985-2013 is used to estimate the role of financial sector on economic growth, focuses on 67 countries. The second data set, 2000-2013 determine the role of institution on financial sector and economic growth by applying 2SLS estimation method. We define institutional variables as set of indicators: Control of Corruption, Political Stability and Absence of Violence, and Voice and Accountability provide declining impact of FDI to economic growth.

Institution, Financial Sector, and Economic Growth: Use The Institutions As An Instrument Variable

OpenAIRE

Albertus Girik Allo

2016-01-01

Institution has been investigated having indirect role on economic growth. This paper aims to evaluate whether the quality of institution matters for economic growth. By applying institution as instrumental variable at Foreign Direct Investment (FDI), quality of institution significantly influence economic growth. This study applies two set of data period, namely 1985-2013 and 2000-2013, available online in the World Bank (WB). The first data set, 1985-2013 is used to estimate the role of fin...

Multinationals and Institutional Competitiveness

DEFF Research Database (Denmark)

Hull Kristensen, Peer; Morgan, Glenn

This article discusses how institutional competitiveness and multinationals are mutually enriching concepts. Seen from the perspective of Multinationals, institutional competitiveness becomes expressed at two levels. At the level of corporate HQs institutional competitiveness proves itself...... competitiveness of Liberal Market Economies and Coordinated Markets Economies under the current competitive regime....

Risk scoring and thromboprophylactic treatment of patients with atrial fibrillation with and without access to primary healthcare data: experience from the Stockholm health care system.

Science.gov (United States)

Forslund, Tomas; Wettermark, Björn; Wändell, Per; von Euler, Mia; Hasselström, Jan; Hjemdahl, Paul

2013-12-10

Earlier validation studies of risk scoring by CHA2DS2VASc for assessments of appropriateness of warfarin treatment in patients with atrial fibrillation have been performed solely with diagnoses recorded in hospital based care, even though many patients to a large extent are managed in primary care. Cross-sectional registry study of all 43 353 patients with a diagnosis of non-valvular atrial fibrillation recorded in inpatient care, specialist ambulatory care or primary care in the Stockholm County during 2006-2010. The mean CHA2DS2VASc score was 3.82 (4.67 for women and 3.14 for men). 64% of the entire cohort of patients with atrial fibrillation had the diagnosis in primary care (12% only there). The mean CHA2DS2VASc score of patients with a diagnosis only in inpatient care or specialist ambulatory care increased from 3.63 to 3.83 when comorbidities registered in primary care were added. In 2010 warfarin prescriptions were claimed by 47.2%, and ASA by 41.6% of the entire cohort. 34% of patients with CHA2DS2VASc=1 and 20% with CHA2DS2VASc=0 had warfarin treatment. ASA was more frequently used instead of warfarin among women and elderly patients. Registry CHA2DS2VASc scores were underestimated without co-morbidity data from primary care. Many individuals with scores 0 and 1 were treated with warfarin, despite poor documentation of clinical benefit. In contrast, warfarin appears to be underused and ASA overused among high risk atrial fibrillation patients. Lack of diagnoses from primary care underestimated CHA2DS2VASc scores and may thereby have overestimated treatment benefits in low-risk patients in earlier studies. © 2013.

Immigrant patients' experiences and reflections pertaining to the consultation: a study on patients from Chile, Iran and Turkey in primary health care in Stockholm, Sweden.

Science.gov (United States)

Wiking, Eivor; Saleh-Stattin, Nuha; Johansson, Sven-Erik; Sundquist, Jan

2009-06-01

Our knowledge of the immigrant patient's experiences and reflections regarding consultations in primary health care where interpreters are used is limited. Thus, the primary aim was to explore these experiences and reflections. The second aim was to study whether demographic and migration-related factors are associated with the patient's satisfaction with the consultation and feeling of consolation given by the general practitioner (GP). The third aim was to analyse whether these feelings are related to the time from the booking to the consultation, to self-reported health, symptoms and the patient's experiences. A questionnaire was distributed to 78 consecutive immigrant patients from Chile, Iran and Turkey at 12 primary healthcare centres around Stockholm. The respondents were asked about their background and health status, while open-ended questions focused on their experiences and comments regarding the consultation and cross-cultural communication in general. Ethical approval was obtained. The respondents consisted of 52 patients, 16 from Chile, nine from Iran and 27 from Turkey. Most of the answers concerned communication problems because of language and cultural differences between the GP and the patient and the GP's ability to listen. Therefore, the importance of having a competent interpreter for a satisfactory consultation was stressed. Many of the respondents also felt that the GP's ability to listen to them and understand them is crucial in the consultation. Background facts, including demographic and migration-related factors, health status and factors related to the consultation, did not seem to be associated with the patient's satisfaction and the feeling of consolation. One limitation is that the sample is small and not equally distributed. The use of authorized interpreters during the consultation is essential. The consultation must be based on a patient-centred strategy and adjusted to the patient's educational level. Cultural competence is needed

Multiple Institutional Logics in Inter-Institutional Temporary Organizations

DEFF Research Database (Denmark)

Pemsel, Sofia; Söderlund, Jonas

for the planning and construction of a new super hospital in the capital of Sweden. Our empirical data demonstrates the important role institutional logics contribute with in understanding logics behind actions as well as emerging conflicts in practice throughout the project process. The paper identifies four......The idea of multiple institutional logics currently draws more and more attention as many organizational actors are forced to operate in ever more complex, temporary and vivid collaborations. We draw on findings from a unique case study of a temporary organization that carried the responsibility...

Going Beyond the Word

DEFF Research Database (Denmark)

Groth, Sanne Krogh

2015-01-01

An article about the English sound poet Bob Cobbing and the work he did at the Text Sound Festivals in Stockholm.......An article about the English sound poet Bob Cobbing and the work he did at the Text Sound Festivals in Stockholm....

Does heavy physical exertion trigger myocardial infarction?

DEFF Research Database (Denmark)

Hallqvist, J; Möller, J; Ahlbom, A

2000-01-01

To study possible triggering of first events of acute myocardial infarction by heavy physical exertion, the authors conducted a case-crossover analysis (1993-1994) within a population-based case-referent study in Stockholm County, Sweden (the Stockholm Heart Epidemiology Program). Interviews were...

Formal Institutions and Subjective Wellbeing

DEFF Research Database (Denmark)

Bjørnskov, Christian; Dreher, Axel; Fischer, Justina A.V.

2010-01-01

A long tradition in economics explores the association between the quality of formal institutions and economic performance. The literature on the relationship between such institutions and happiness is, however, rather limited, and inconclusive. In this paper, we revisit the findings from recent...... cross-country studies on the institution-happiness association. Our findings suggest that their conclusions are qualitatively rather insensitive to the specific measure of 'happiness' used, while the associations between formal institutions and subjective well-being differ among poor and rich countries....... Separating different types of institutional quality, we find that in low-income countries the effects of economic-judicial institutions on happiness dominate those of political institutions, while analyses restricted to middle- and high-income countries show strong support for an additional beneficial effect...

Performance Assessment Institute-NV

Energy Technology Data Exchange (ETDEWEB)

Lombardo, Joesph [Univ. of Nevada, Las Vegas, NV (United States)

2012-12-31

The National Supercomputing Center for Energy and the Environment’s intention is to purchase a multi-purpose computer cluster in support of the Performance Assessment Institute (PA Institute). The PA Institute will serve as a research consortium located in Las Vegas Nevada with membership that includes: national laboratories, universities, industry partners, and domestic and international governments. This center will provide a one-of-a-kind centralized facility for the accumulation of information for use by Institutions of Higher Learning, the U.S. Government, and Regulatory Agencies and approved users. This initiative will enhance and extend High Performance Computing (HPC) resources in Nevada to support critical national and international needs in "scientific confirmation". The PA Institute will be promoted as the leading Modeling, Learning and Research Center worldwide. The program proposes to utilize the existing supercomputing capabilities and alliances of the University of Nevada Las Vegas as a base, and to extend these resource and capabilities through a collaborative relationship with its membership. The PA Institute will provide an academic setting for interactive sharing, learning, mentoring and monitoring of multi-disciplinary performance assessment and performance confirmation information. The role of the PA Institute is to facilitate research, knowledge-increase, and knowledge-sharing among users.

INSTITUTIONAL REPOSITORY: EMPLOYMENT IN EDUCATION

Directory of Open Access Journals (Sweden)

Vasyl P. Oleksyuk

2012-11-01

Full Text Available The article investigated the concept of «institutional repository» and determined the aspects of institutional repositories in higher education. Institutional Repositories are information systems that allow preserving, storing and disseminating scientific knowledge produced in higher education and scientific research institutions. This study presented the main aspects using institutional repositories in educational process (such as storage of scientific and educational information, means of organization activity of students, object of studying. This article produced the structure of communities and collections of the institutional. It is described the experience of implementing of DSpace in the learning process.

The Emergence of a Proto-institution

DEFF Research Database (Denmark)

Boxenbaum, Eva

2004-01-01

of inter-organizational networks, and actors embedded in multiple fields. The making of the proto-institution is intentional, yet the institutional building blocks and the apparent interests of actors are institutionally embedded. The results from this micro-dynamic analysis suggest revisions to current...... conceptualizations of institutional change processes. Keywords: Institutional change, proto-institution, cognition, institutional entrepreneurship, innovation, collaborative networks....

Institutional Inertia and Institutional Change in an Expanding Normal-Form Game

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Torsten Heinrich

2013-08-01

Full Text Available We investigate aspects of institutional change in an evolutionary game-theoretic framework, in principle focusing on problems of coordination in groups when new solutions to a problem become available. In an evolutionary game with an underlying dilemma structure, we let a number of new strategies become gradually available to the agents. The dilemma structure of the situation is not changed by these. Older strategies offer a lesser payoff than newly available ones. The problem that agents have to solve for realizing improved results is, therefore, to coordinate on newly available strategies. Strategies are taken to represent institutions; the coordination on a new strategy by agents, hence, represents a change in the institutional framework of a group. The simulations we run show a stable pattern regarding such institutional changes. A number of institutions are found to coexist, with the specific number depending on the relation of payoffs achievable through the coordination of different strategies. Usually, the strategies leading to the highest possible payoff are not among these. This can be taken to reflect the heterogeneity of rules in larger groups, with different subgroups showing different behavior patterns.

Changing institutions of knowing

DEFF Research Database (Denmark)

Koch, Christian; Bertelsen, Niels Haldor

2014-01-01

paper is to analyze enablers and barriers for this institutional change. The vocational education system in Denmark is strongly institutionalised with unions, employerÕs associations and the schools in central roles. Drawing on institutional theory contributions on labour market -, educational......In order to reach the EU 2020 goals for the climate, Danish vocational training units are currently in a process of institutional change triggered by the need of providing energy, and new process competences for the skilled and semiskilled workforce active in construction. The aim of the present...... - and professional institutions, the paper presents a study of institutional work inside and across schools and craft disciplines working in SMEs involved in new building and renovation with an energy aspect. Collaboration between four education committees for carpenters, masons, electricians and plumbers...

Illegal handling of radioactive and nuclear materials. Threats and suggestions for measures

International Nuclear Information System (INIS)

Oliver, Lena; Melin, Lena; Prawitz, Jan; Ringbom, Anders; Sandstroem, Bjoern; Wigg, Lars; Wirstam, Jens

2004-01-01

This project deals with threats from smuggling or other illegal transportation of radioactive or nuclear materials across the borders to Sweden, and with the security of handling such materials in Sweden. The project has included studies of relevant documentation; visits and interviews at industries, hospitals, research institutes and military institutions in Sweden that handle radioactive materials; a pilot study at the Stockholm freeport, where equipment for detection of radioactive materials has been tested for six months; an analysis of incidents reported to the IAEA database; and an analysis of Swedish incidents. The following conclusions are drawn: Stricter rules regarding the physical protection of radiation sources and radioactive materials should be implemented in Sweden. The recommendations recently issued by IAEA should serve as a point of departure for working out such rules

Progress report from the Studsvik Neutron Research Laboratory 1990-91

International Nuclear Information System (INIS)

Dahlborg, U.; Ebbsjoe, I.; Holmqvist, B.

1992-01-01

The Studsvik Neutron Research Laboratory (NFL) is the base for the research activities at the Studsvik reactors. It is administrated by the University of Uppsala and is established to facilitate reactor based research. The laboratory is intended to, in co-operation with institutes and department at universities in Sweden, develop, construct and maintain experimental equipment for this kind of research and to make it available for scientists at Swedish universities and, if possible, also to scientists outside the universities. The research at the Studsvik facilities has during 1990 and 1991 been performed by groups form Uppsala University, Royal Institute of Technology, Stockholm, Chalmers Technical University, Gothenburg, and by scientists at NFL. The research programme of the groups is divided into three main areas, scattering of thermal neutrons, nuclear chemistry/nuclear physics, and neutron capture radiography

Surgery-related complications in 1253 robot-assisted and 485 open retropubic radical prostatectomies at the Karolinska University Hospital, Sweden.

Science.gov (United States)

Carlsson, Stefan; Nilsson, Andreas E; Schumacher, Martin C; Jonsson, Martin N; Volz, Daniela S; Steineck, Gunnar; Wiklund, Peter N

2010-05-01

To quantify complications to surgery in patients treated with robot-assisted radical prostatectomy (RARP) and open retropubic radical prostatectomy (RRP) at our institution. Radical prostatectomy is associated with specific complications that can affect outcome results in patients. Between January 2002 and August 2007, a series of 1738 consecutive patients underwent RARP (n = 1253) or RRP (n = 485) for clinically localized prostate cancer. Surgery-related complications were assessed using a prospective hospital-based complication registry. The baseline characteristics of all patients were documented preoperatively. Overall, 170 patients required blood transfusions (9.7%), 112 patients (23%) in the RRP group compared with 58 patients (4.8%) in the RARP group. Infectious complications occurred in 44 RRP patients (9%) compared with 18 (1%) in the RARP group. Bladder neck contracture was treated in 22 (4.5%) patients who had undergone RRP compared with 3 (0.2%) in the RARP group. Clavien grade IIIb-V complications were more common in RRP patients (n = 63; 12.9%) than in RARP patients (n = 46; 3.7%). The introduction of RARP at our institution has resulted in decreased number of patients with Clavien grade IIIb-V complications, such as bladder neck contractures, a decrease in the number of patients who require blood transfusions, and decreased numbers of patients with postoperative wound infections. Copyright 2010 Elsevier Inc. All rights reserved.

Institutional complexity: a bibliometric on recent publication in institutional theory [doi: 10.21529/RECADM.2016009

Directory of Open Access Journals (Sweden)

Fernanda Reis da Silva

2016-08-01

Full Text Available In this bibliometric study we discuss the institutional complexity in eleven journals in business administration and organization studies. We try to identify the main features of the present Institutional Theory discussion in organization theory. The main research techniques we used were citation, co-citation, factorial bibliometric analysis and multidimensional scaling to identify the most influential studies and the main themes that are interwoven in institutional complexity (institutional logics, conflicts, changes and identity. The sample consisted of 43 articles and more than 3000 references cited. The most cited works were grouped into three factors that represent the emergent topics in institutional complexity. The results show the emergence of a new set of important concepts in the context of the institutional theory, such as institutional logics, conflict, change, identity, strategy. That set of concepts is diverse from that one typical of the institutionalism in organizations, in the 90´s. Complementarily, we identify authors and papers that can be considered central in organizational institutionalism, according to the journals that we take as part of our sample.

Using a Theoretical Framework of Institutional Culture to Analyse an Institutional Strategy Document

Science.gov (United States)

Jacobs, Anthea Hydi Maxine

2016-01-01

This paper builds on a conceptual analysis of institutional culture in higher education. A theoretical framework was proposed to analyse institutional documents of two higher education institutions in the Western Cape, for the period 2002 to 2012 (Jacobs 2012). The elements of this theoretical framework are "shared values and beliefs",…

Studying institutional work in organizations

DEFF Research Database (Denmark)

Bjerregaard, Toke

2011-01-01

Purpose – In order to provide new and other directions to institutional studies in organization theory, Lawrence and Suddaby forward the notion of institutional work of actors aimed at maintaining, changing and disrupting institutions. The purpose of this paper is to further theory and method...... in studying the institutional work of people in organizations. Design/methodology/approach – Methodological insights from the ways in which theories of human agency in institutional contexts have co-evolved with field study methodologies are analyzed in related fields of research, particularly in sociology...... and anthropology. Findings – The ways have been analyzed in which social theories of human agency in institutional contexts and field methodology have co-evolved in an inter-disciplinary perspective. The analysis shows how field methodologies may provide inspirations to theory and method in studying institutional...

Imitation Modeling and Institutional Studies

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Maksim Y. Barbashin

2017-09-01

Full Text Available This article discusses the use of imitation modeling in the conduct of institutional research. The institutional approach is based on the observation of social behavior. To understand a social process means to determine the key rules that individuals use, undertaking social actions associated with this process or phenomenon. This does not mean that institutions determine behavioral reactions, although there are a number of social situations where the majority of individuals follow the dominant rules. If the main laws of development of the institutional patterns are known, one can describe most of the social processes accurately. The author believes that the main difficulty with the analysis of institutional processes is their recursive nature: from the standards of behavior one may find the proposed actions of social agents who follow, obey or violate institutions, but the possibility of reconstructive analysis is not obvious. The author demonstrates how the institutional approach is applied to the analysis of social behavior. The article describes the basic principles and methodology of imitation modeling. Imitation modeling reveals the importance of institutions in structuring social transactions. The article concludes that in the long term institutional processes are not determined by initial conditions.

Taking Stock on Institutional Entrepreneurship

DEFF Research Database (Denmark)

Leca, Bernard; Battilana, Julie; Boxenbaum, Eva

2006-01-01

This paper analyzes the literature that has been published on institutional entrepreneurship since Paul DiMaggio introduced this notion in 1988. Based on a systematic selection and analysis of articles, the paper outlines an emerging consensus on the definition and process of institutional entrep...... may use this paper to build targeted and sophisticated research designs that add value to the emerging body of literature on institutional entrepreneurship.Keywords: Institutional Entrepreneur, Institutional Change, Paradox of Embedded Agency...

Market reforms in Swedish health care

DEFF Research Database (Denmark)

Diderichsen, Finn

1993-01-01

This report presents the main characteristics of reforms in the Swedish health services, as exemplified by the "Stockholm Model" introduced in 1992 in Stockholm county. The author discusses the motives behind these reforms, the already-evident increases in costs that are occurring, and the effect...

Institutional Awareness

DEFF Research Database (Denmark)

Ahlvik, Carina; Boxenbaum, Eva

Drawing on dual-process theory and mindfulness research this article sets out to shed light on the conditions that need to be met to create “a reflexive shift in consciousness” argued to be a key foundational mechanism for agency in institutional theory. Although past research has identified...... in consciousness to emerge and argue for how the varying levels of mindfulness in the form of internal and external awareness may manifest as distinct responses to the institutional environment the actor is embedded in....

Endogenous and costly institutional deterrence

Science.gov (United States)

David C. Kingsley; Thomas C. Brown

2014-01-01

Modern economies rely on central-authority institutions to regulate individual behaviour. Despite the importance of such institutions little is known about their formation within groups. In a public good experiment, groups selected the level of deterrence implemented by the institution, knowing that the administrative costs of the institution rose with the level of...

Institutional analysis for energy policy

Energy Technology Data Exchange (ETDEWEB)

Morris, F.A.; Cole, R.J.

1980-07-01

This report summarizes principles, techniques, and other information for doing institutional analyses in the area of energy policy. The report was prepared to support DOE's Regional Issues Identification and Assessment (RIIA) program. RIIA identifies environmental, health, safety, socioeconomic, and institutional issues that could accompany hypothetical future scenarios for energy consumption and production on a regional basis. Chapter 1 provides some theoretical grounding in institutional analysis. Chapter 2 provides information on constructing institutional maps of the processes for bringing on line energy technologies and facilities contemplated in RIIA scenarios. Chapter 3 assesses the institutional constraints, opportunities, and impacts that affect whether these technologies and facilities would in fact be developed. Chapters 4 and 5 show how institutional analysis can support use of exercises such as RIIA in planning institutional change and making energy policy choices.

Institutions and Modernity

Directory of Open Access Journals (Sweden)

Witold Morawski

2013-09-01

Full Text Available Purpose: Modernity consists of many confl icting aspects: It brings many empty promises, yet has resulted in new institutions that create bridges between the values and interests of millions of people who seek freedom, prosperity, quality of life, strengthened democracy and social justice. In this paper I attempt to a gain and loss account against modernity, because institutional rules are not only conducive to cooperative interactions, but to hostile interactions as well. People are not always guided by moral commitment, but rather more often driven by cold calculation or coercion.Methodology: Modernity has at least three defi nitions. The fi rst defi nition is based on ideas that took over the imagination of the era. The second defi nition is based on an analysis of the behavior of people who respond to reason as well as emotion and believe that they act more rationally than their ancestors or the traditional “others”. The third defi nition is the one closest to my heart, consisting of the use of institutional categories. Institutions offer practical ways of connecting ideas and people. The challenge for them is the result of deepening local and national interdependencies, but increasingly often also regional (e.g. European and global. Interdependencies are the result of the scientifi c and technological revolution, global markets, global governance mechanisms, the emergence of new social forces and cultural confl icts (against the background of reconciling identity and differences.Conclusions: The most important task is to identify the mechanisms of complex systems so that people know how to act under conditions of uncertainty, risk and crisis. Hence, the expectations toward institutions often exceed their abilities. Even though new institutions are being created and old ones are being fixed, we are witnessing and participating in, institutional paralysis and the decay (e.g. corruption. In this situation, it is imperative not only to

Lise Meitner A Life in Physics

CERN Document Server

Sime, Ruth Lewin

1996-01-01

Lise Meitner (1878-1968) was a pioneer of nuclear physics and co-discoverer, with Otto Hahn and Fritz Strassmann, of nuclear fission. Braving the sexism of the scientific world, she joined the prestigious Kaiser Wilhelm Institute for Chemistry and became a prominent member of the international physics community. Of Jewish origin, Meitner fled Nazi Germany for Stockholm in 1938 and later moved to Cambridge, England. Her career was shattered when she fled Germany, and her scientific reputation was damaged when Hahn took full credit-and the 1944 Nobel Prize-for the work they had done together on

Toward a definition of a threshold for harmless doses to the anal-sphincter region and the rectum

International Nuclear Information System (INIS)

Al-Abany, Massoud; Helgason, Asgeir R.; Agren Cronqvist, Anna-Karin; Lind, Bengt; Mavroidis, Panayiotis; Wersaell, Peter; Lind, Helena; Qvanta, Eva; Steineck, Gunnar

2005-01-01

Purpose: To investigate dysfunction caused by unwanted radiation to the anal-sphincter region and the rectum. Methods and materials: A questionnaire assessing bowel symptoms, sexual function, and urinary symptoms was sent to 72 patients with clinically localized prostatic adenocarcinoma treated by external beam radiation therapy at the Radiumhemmet, Karolinska Hospital, in Stockholm, Sweden, 2-4 years after treatment. The mean percentage dose-volume histograms for patients with and without the specific symptom were calculated. Results: Of the 65 patients providing information, 9 reported fecal leakage, 10 blood and mucus in stools, 10 defecation urgency, and 7 diarrhea or loose stools. None of the 19 and 13 patients who received, respectively, a dose of ≥35 Gy to ≤60% or ≥40 Gy to ≤40% of the anal-sphincter region volume reported fecal leakage (p < 0.05). In dose-volume histograms, a statistically significant correlation was found between radiation to the anal-sphincter region and the risk of fecal leakage in the interval 45-55 Gy. There was also a statistically significant correlation between radiation to the rectum and the risk of defecation urgency and diarrhea or loose stools in the interval 25-42 Gy. No relationship was found between anatomic rectal wall volume and the investigated late effects. Conclusions: Although the limited data in this study prevent the definition of a conclusive threshold regarding volume and dose to the anal-sphincter region and untoward morbidity, it seems that careful monitoring of unnecessary irradiation to this area should be done because it can potentially help reduce the risk of adverse effects, such as fecal leakage. Future studies should pay more attention to the anal-sphincter region and help to more rigorously define its radiotherapeutic tolerance

Acute effects of glossopharyngeal insufflation in people with cervical spinal cord injury.

Science.gov (United States)

Nygren-Bonnier, Malin; Schiffer, Tomas A; Lindholm, Peter

2018-01-01

To evaluate acute effects of glossopharyngeal insufflation (GI) on lung function, airway pressure (P aw ), blood pressure and heart rate (HR) in people with cervical spinal cord injury (CSCI). Case-control design. Karolinska Institutet, Stockholm, Sweden. Ten participants with CSCI suffering from lesions between C4 and C8, and ASIA classification of A or B were recruited. Ten healthy particpants familiar with GI were recruited as a reference group. Spirometry, mean arterial blood pressure (MAP), P aw, and HR were measured in a sitting and a supine position before, during, and after GI. GI in the study group in a sitting position increased total lung capacity (TLC) by 712 ml: P < 0.001, vital capacity (VC) by 587 ml: P < 0.0001, P aw by 13 cm H 2 O: P < 0.01, and HR by 10 beats/min: P < 0.001. MAP decreased by 25 mmHg, P < 0.0001. Significant differences were observed between groups comparing baseline with GI. The reference group had a higher increase in; TLC (P < 0.01), VC (P < 0.001), P aw (P < 0.001) and HR (P < 0.05) and a higher decrease in MAP (P < 0.001). With GI in a sitting compared to a supine position, TLC, MAP, HR, P aw remained unchanged in the study group, while residual volume decreased in the supine position (P < 0.01). There was a difference between the groups in the increase in TLC; VC; P aw, HR and in the decrease in MAP with GI, however MAP, HR and P aw responded in similar way in both groups in a sitting as well as a supine position. If performed correctly, the risks of GI resulting in clinically significant hemodynamic changes is low, although syncope may still occur.

Reliability and concurrent validity of postural asymmetry measurement in adolescent idiopathic scoliosis.

Science.gov (United States)

Prowse, Ashleigh; Aslaksen, Berit; Kierkegaard, Marie; Furness, James; Gerdhem, Paul; Abbott, Allan

2017-01-18

To investigate the reliability and concurrent validity of the Baseline ® Body Level/Scoliosis meter for adolescent idiopathic scoliosis postural assessment in three anatomical planes. This is an observational reliability and concurrent validity study of adolescent referrals to the Orthopaedic department for scoliosis screening at Karolinska University Hospital, Stockholm, Sweden between March-May 2012. A total of 31 adolescents with idiopathic scoliosis (13.6 ± 0.6 years old) of mild-moderate curvatures (25° ± 12°) were consecutively recruited. Measurement of cervical, thoracic and lumbar curvatures, pelvic and shoulder tilt, and axial thoracic rotation (ATR) were performed by two trained physiotherapists in one day. The intraclass correlation coefficient (ICC) was used to determine the inter-examiner reliability (ICC2,1) and the intra-rater reliability (ICC3,3) of the Baseline ® Body Level/Scoliosis meter. Spearman's correlation analyses were used to estimate concurrent validity between the Baseline ® Body Level/Scoliosis meter and Gold Standard Cobb angles from radiographs and the Orthopaedic Systems Inc. Scoliometer. There was excellent reliability between examiners for thoracic kyphosis (ICC2,1 = 0.94), ATR (ICC2,1 = 0.92) and lumbar lordosis (ICC2,1 = 0.79). There was adequate reliability between examiners for cervical lordosis (ICC2,1 = 0.51), however poor reliability for pelvic and shoulder tilt. Both devices were reproducible in the measurement of ATR when repeated by one examiner (ICC3,3 0.98-1.00). The device had a good correlation with the Scoliometer (rho = 0.78). When compared with Cobb angle from radiographs, there was a moderate correlation for ATR (rho = 0.627). The Baseline ® Body Level/Scoliosis meter provides reliable transverse and sagittal cervical, thoracic and lumbar measurements and valid transverse plan measurements of mild-moderate scoliosis deformity.

INSTITUTION vs. ORGANIZATION. CONCEPTUAL DELIMITATIONS

Directory of Open Access Journals (Sweden)

Andrea Sveda ANGEL

2011-06-01

Full Text Available Both organizations and institutions are social structures. On the basis of the institutions arethe formal rules and at the basis of the organizations are the interactions between peoples withcommon aims. The evolution of the institutions is explained by the institutionalism with its twoorientations: the new institutionalism and the old institutionalism. The last one was preoccupied bythe transformation of the economy and by the evolution of the technology and the newinstitutionalism explains the existence of the institutions from the individual’s point of view.Organizations were and are studied in present days from different point of views: organizationalstructure and culture, organizational change and development. The organization was classifiedaccording to several factors: aim, size, legal form, or their operational domain. Thecharacterization of the organization through metaphors such as machines, culture, brain, ororganism proves their complexity and diversity. Regarding to the relations between institution andorganization, the relationship could be characterised as interdependence because the organizationscan determine instituional changes, by offering a framework for the application of the rules.

[Johan Eellend. Cultivating the Rural Citizen : Modernity, Agrarianism and Citizenship in Late Tsarist Estonia] / Kersti Lust

Index Scriptorium Estoniae

Lust, Kersti, 1976-

2008-01-01

Arvustus: Eellend, Johan. Cultivating the Rural Citizien : Modernity, Agrarianism and Citizenship in Late Tsarist Estonia. Stockholm : Stockholm Universty, 2007. Eesti agraarideoloogia kujunemist ja olemust käsitlevast dissertatsioonist. Tegemist on Eesti ühiskondliku mõtte voolude ja nende mõjuulatuse tavapärasest erineva nägemusega

Institutional Support : Ethiopian Development Research Institute ...

International Development Research Centre (IDRC) Digital Library (Canada)

The Ethiopian Development Research Institute (EDRI) was established in 1999 and became operational in 2003 as a semi-autonomous organization accountable to ... International Water Resources Association, in close collaboration with IDRC, is holding a webinar titled “Climate change and adaptive water management: ...

Political Institutions and Their Historical Dynamics

Science.gov (United States)

Sandberg, Mikael; Lundberg, Per

2012-01-01

Traditionally, political scientists define political institutions deductively. This approach may prevent from discovery of existing institutions beyond the definitions. Here, a principal component analysis was used for an inductive extraction of dimensions in Polity IV data on the political institutions of all nations in the world the last two centuries. Three dimensions of institutions were revealed: core institutions of democracy, oligarchy, and despotism. We show that, historically and on a world scale, the dominance of the core institutions of despotism has first been replaced by a dominance of the core institutions of oligarchy, which in turn is now being followed by an increasing dominance by the core institutions of democracy. Nations do not take steps from despotic, to oligarchic and then to democratic institutions, however. Rather, nations hosting the core democracy institutions have succeeded in historically avoiding both the core institutions of despotism and those of oligarchy. On the other hand, some nations have not been influenced by any of these dimensions, while new institutional combinations are increasingly influencing others. We show that the extracted institutional dimensions do not correspond to the Polity scores for autocracy, “anocracy” and democracy, suggesting that changes in regime types occur at one level, while institutional dynamics work on another. Political regime types in that sense seem “canalized”, i.e., underlying institutional architectures can and do vary, but to a considerable extent independently of regime types and their transitions. The inductive approach adds to the deductive regime type studies in that it produces results in line with modern studies of cultural evolution and memetic institutionalism in which institutions are the units of observation, not the nations that acts as host for them. PMID:23056219

Institutional Investors as Minority Shareholders

OpenAIRE

Assaf Hamdani; Yishay Yafeh

2013-01-01

We examine the link between minority shareholders' rights and corporate governance by studying institutional investors' voting patterns in a concentrated ownership environment. Institutions rarely vote against insider-sponsored proposals even when the law empowers the minority. Institutions vote against compensation-related proposals more often than against related party transactions even when minority shareholders cannot influence outcomes. Potentially conflicted institutions are more likely...

Adaptation research meets adaptation decision-making. Second Nordic international conference on climate change adaption. Programme and abstracts

Energy Technology Data Exchange (ETDEWEB)

NONE

2012-07-01

Nearly two years have passed since a small team of researchers began a new chapter in Nordic co-operation on climate change by organising a conference in Stockholm, Sweden. The conference, entitled Climate Adaptation in the Nordic Countries - Science, Practice, Policy, co-ordinated by the Stockholm Environment Institute and hosted by Stockholm University in November 2010, was the first of its kind in the Nordic region. Since the European Commission adopted its White Paper on adaptation to climate change in 2009, many of that document's 33 actions have been implemented, a climate change adaptation platform, Climate-ADAPT, was launched at the European Environment Agency in March this year, and just a week before this conference the Commission concluded a public consultation of stakeholders and experts in member states designed to feed into the preparation of a European Union adaptation strategy. The 2012 conference therefore presents an ideal opportunity to take stock of ongoing efforts and to consider how adaptation research efforts are keeping pace with policy demands as well as the needs of public and private decision-makers operating at a range of scales. It brings together researchers, public and private decision- makers, as well as those who plan and realize adaptation plans. Session themes include, among others: national and local adaptation plans, climate portals and climate services, adaptation in developing countries, legal aspects of adaptation, economic appraisal of adaptation, analysing and handling risk and uncertainty, urban planning and scenarios. The contributors have very diverse backgrounds, ranging from biosciences to social sciences, economics to geo-sciences, and engineering to architecture. Interest in climate change adaptation in the Nordic region is clearly high, with over 70% of our participants drawn from the five Nordic countries, but the conference has also managed to attract participation from further afield, with registrations

A radiation-tolerant electronic readout system for portal imaging

Science.gov (United States)

Östling, J.; Brahme, A.; Danielsson, M.; Iacobaeus, C.; Peskov, V.

2004-06-01

A new electronic portal imaging device, EPID, is under development at the Karolinska Institutet and the Royal Institute of Technology. Due to considerable demands on radiation tolerance in the radiotherapy environment, a dedicated electronic readout system has been designed. The most interesting aspect of the readout system is that it allows to read out ˜1000 pixels in parallel, with all electronics placed outside the radiation beam—making the detector more radiation resistant. In this work we are presenting the function of a small prototype (6×100 pixels) of the electronic readout board that has been tested. Tests were made with continuous X-rays (10-60 keV) and with α particles. The results show that, without using an optimised gas mixture and with an early prototype only, the electronic readout system still works very well.