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  1. A practical divergence measure for survival distributions that can be estimated from Kaplan-Meier curves.

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    Cox, Trevor F; Czanner, Gabriela

    2016-06-30

    This paper introduces a new simple divergence measure between two survival distributions. For two groups of patients, the divergence measure between their associated survival distributions is based on the integral of the absolute difference in probabilities that a patient from one group dies at time t and a patient from the other group survives beyond time t and vice versa. In the case of non-crossing hazard functions, the divergence measure is closely linked to the Harrell concordance index, C, the Mann-Whitney test statistic and the area under a receiver operating characteristic curve. The measure can be used in a dynamic way where the divergence between two survival distributions from time zero up to time t is calculated enabling real-time monitoring of treatment differences. The divergence can be found for theoretical survival distributions or can be estimated non-parametrically from survival data using Kaplan-Meier estimates of the survivor functions. The estimator of the divergence is shown to be generally unbiased and approximately normally distributed. For the case of proportional hazards, the constituent parts of the divergence measure can be used to assess the proportional hazards assumption. The use of the divergence measure is illustrated on the survival of pancreatic cancer patients. Copyright © 2016 John Wiley & Sons, Ltd.

  2. Understanding survival analysis: Kaplan-Meier estimate

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    Goel, Manish Kumar; Khanna, Pardeep; Kishore, Jugal

    2010-01-01

    Kaplan-Meier estimate is one of the best options to be used to measure the fraction of subjects living for a certain amount of time after treatment. In clinical trials or community trials, the effect of an intervention is assessed by measuring the number of subjects survived or saved after that intervention over a period of time. The time starting from a defined point to the occurrence of a given event, for example death is called as survival time and the analysis of group data as survival analysis. This can be affected by subjects under study that are uncooperative and refused to be remained in the study or when some of the subjects may not experience the event or death before the end of the study, although they would have experienced or died if observation continued, or we lose touch with them midway in the study. We label these situations as censored observations. The Kaplan-Meier estimate is the simplest way of computing the survival over time in spite of all these difficulties associated with subjects or situations. The survival curve can be created assuming various situations. It involves computing of probabilities of occurrence of event at a certain point of time and multiplying these successive probabilities by any earlier computed probabilities to get the final estimate. This can be calculated for two groups of subjects and also their statistical difference in the survivals. This can be used in Ayurveda research when they are comparing two drugs and looking for survival of subjects. PMID:21455458

  3. A review and comparison of methods for recreating individual patient data from published Kaplan-Meier survival curves for economic evaluations: a simulation study.

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    Xiaomin Wan

    Full Text Available In general, the individual patient-level data (IPD collected in clinical trials are not available to independent researchers to conduct economic evaluations; researchers only have access to published survival curves and summary statistics. Thus, methods that use published survival curves and summary statistics to reproduce statistics for economic evaluations are essential. Four methods have been identified: two traditional methods 1 least squares method, 2 graphical method; and two recently proposed methods by 3 Hoyle and Henley, 4 Guyot et al. The four methods were first individually reviewed and subsequently assessed regarding their abilities to estimate mean survival through a simulation study.A number of different scenarios were developed that comprised combinations of various sample sizes, censoring rates and parametric survival distributions. One thousand simulated survival datasets were generated for each scenario, and all methods were applied to actual IPD. The uncertainty in the estimate of mean survival time was also captured.All methods provided accurate estimates of the mean survival time when the sample size was 500 and a Weibull distribution was used. When the sample size was 100 and the Weibull distribution was used, the Guyot et al. method was almost as accurate as the Hoyle and Henley method; however, more biases were identified in the traditional methods. When a lognormal distribution was used, the Guyot et al. method generated noticeably less bias and a more accurate uncertainty compared with the Hoyle and Henley method.The traditional methods should not be preferred because of their remarkable overestimation. When the Weibull distribution was used for a fitted model, the Guyot et al. method was almost as accurate as the Hoyle and Henley method. However, if the lognormal distribution was used, the Guyot et al. method was less biased compared with the Hoyle and Henley method.

  4. On an exponential bound for the Kaplan-Meier estimator.

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    Wellner, Jon A

    2007-12-01

    We review limit theory and inequalities for the Kaplan-Meier Kaplan and Meier (J Am Stat Assoc 53:457-481, 1958) product limit estimator of a survival function on the whole line [Formula: see text] . Along the way we provide bounds for the constant in an interesting inequality due to Biotouzé et al. (Ann Inst H Poincaré Probab Stat 35:735-763, 1999), and provide some numerical evidence in support of one of their conjectures.

  5. A comparison between Kaplan-Meier and weighted Kaplan-Meier methods of five-year survival estimation of patients with gastric cancer.

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    Zare, Ali; Mahmoodi, Mahmood; Mohammad, Kazem; Zeraati, Hojjat; Hosseini, Mostafa; Holakouie Naieni, Kourosh

    2014-01-01

    The 5-year survival rate is a good prognostic indicator for patients with Gastric cancer that is usually estimated based on Kaplan-Meier. In situations where censored observations are too many, this method produces biased estimations. This study aimed to compare estimations of Kaplan-Meier and Weighted Kaplan-Meier as an alternative method to deal with the problem of heavy-censoring. Data from 330 patients with Gastric cancer who had undergone surgery at Iran Cancer Institute from 1995- 1999 were analyzed. The Survival Time of these patients was determined after surgery, and the 5-year survival rate for these patients was evaluated based on Kaplan-Meier and Weighted Kaplan-Meier methods. A total of 239 (72.4%) patients passed away by the end of the study and 91(27.6%) patients were censored. The mean and median of survival time for these patients were 24.86±23.73 and 16.33 months, respectively. The one-year, two-year, three-year, four-year, and five-year survival rates of these patients with standard error estimation based on Kaplan-Meier were 0.66 (0.0264), 0.42 (0.0284), 0.31 (0.0274), 0.26 (0.0264) and 0.21 (0.0256) months, respectively. The estimations of Weighted Kaplan-Meier for these patients were 0.62 (0.0251), 0.35 (0.0237), 0.24 (0.0211), 0.17 (0.0172), and 0.10 (0.0125) months, consecutively. In cases where censoring assumption is not made, and the study has many censored observations, estimations obtained from the Kaplan-Meier are biased and are estimated higher than its real amount. But Weighted Kaplan-Meier decreases bias of survival probabilities by providing appropriate weights and presents more accurate understanding.

  6. A comparison between Kaplan-Meier and weighted Kaplan-Meier methods of five-year survival estimation of patients with gastric cancer.

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    Ali Zare

    2014-10-01

    Full Text Available The 5-year survival rate is a good prognostic indicator for patients with Gastric cancer that is usually estimated based on Kaplan-Meier. In situations where censored observations are too many, this method produces biased estimations. This study aimed to compare estimations of Kaplan-Meier and Weighted Kaplan-Meier as an alternative method to deal with the problem of heavy-censoring. Data from 330 patients with Gastric cancer who had undergone surgery at Iran Cancer Institute from 1995- 1999 were analyzed. The Survival Time of these patients was determined after surgery, and the 5-year survival rate for these patients was evaluated based on Kaplan-Meier and Weighted Kaplan-Meier methods. A total of 239 (72.4% patients passed away by the end of the study and 91(27.6% patients were censored. The mean and median of survival time for these patients were 24.86±23.73 and 16.33 months, respectively. The one-year, two-year, three-year, four-year, and five-year survival rates of these patients with standard error estimation based on Kaplan-Meier were 0.66 (0.0264, 0.42 (0.0284, 0.31 (0.0274, 0.26 (0.0264 and 0.21 (0.0256 months, respectively. The estimations of Weighted Kaplan-Meier for these patients were 0.62 (0.0251, 0.35 (0.0237, 0.24 (0.0211, 0.17 (0.0172, and 0.10 (0.0125 months, consecutively. In cases where censoring assumption is not made, and the study has many censored observations, estimations obtained from the Kaplan-Meier are biased and are estimated higher than its real amount. But Weighted Kaplan-Meier decreases bias of survival probabilities by providing appropriate weights and presents more accurate understanding.

  7. Kaplan-Meier analysis on seizure outcome after epilepsy surgery: do gender and race influence it?

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    Burneo, Jorge G; Villanueva, Vicente; Knowlton, Robert C; Faught, R Edward; Kuzniecky, Ruben I

    2008-06-01

    To evaluate seizure outcome following epilepsy surgery for patients with temporal lobe epilepsy and evaluate is gender and race/ethnicity influence it. Data were obtained from the discharge database of the University of Alabama at Birmingham, Epilepsy Center, between 1985 and 2001. The sample consisted of all patients with a primary diagnosis of medically intractable temporal lobe epilepsy (TLE) who underwent anterior temporal lobectomy. Seizure recurrence was tabulated at 7 days, 2 months, 6 months, 1, 2, 3, 4, 5, and 6 years following surgery. Logistic regression analysis was used to model the presence of seizure recurrence after anterior temporal lobectomy for all patients. Kaplan-Meier analysis was done to obtain estimates and 95% CIs of seizure freedom from baseline. Baseline variables--age at surgery, age at seizure onset, sex, side of resection, immediate postoperative seizures, and pathology results--were assessed as potential predictors of each outcome by comparing the survival curves within each variable with a log rank test. Three hundred sixty-eight patients underwent surgical treatment for TLE, mean age of 30.2 years. Thirty-five patients were African American, 43% were men. Immediate postoperative seizures were seen in 23 patients, while seizure recurrence occurred in 27.3% patients within a year after surgery, and in 33.6% within 6 years. Logistic regression results showed no differences between African Americans and whites, between males and females. The occurrence of immediate postoperative seizures was a strong predictor of late seizure recurrence only at 1 year after surgery. The occurrence of seizures in the immediate postoperative period is a strong predictor of later seizure recurrence. Sex and race/ethnicity do not appear to be predictors of long-term outcome following surgery for temporal lobe epilepsy.

  8. Total Ankle Replacement Survival Rates Based on Kaplan-Meier Survival Analysis of National Joint Registry Data.

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    Bartel, Annette F P; Roukis, Thomas S

    2015-10-01

    National joint registry data provides unique information about primary total ankle replacement (TAR) survival. We sought to recreate survival curves among published national joint registry data sets using the Kaplan-Meier estimator. Overall, 5152 primary and 591 TAR revisions were included over a 2- to 13-year period with prosthesis survival for all national joint registries of 0.94 at 2-years, 0.87 at 5-years and 0.81 at 10-years. National joint registry datasets should strive for completion of data presentation including revision definitions, modes and time of failure, and patients lost to follow-up or death for complete accuracy of the Kaplan-Meier estimator.

  9. A Berry-Essen Inequality for the Kaplan-Meier L-Estimator

    Institute of Scientific and Technical Information of China (English)

    Qi Hua WANG; Li Xing ZHU

    2001-01-01

    LetFn be the Kaplan-Meier estimator of distribution function F. Let J(.) be a measureablereal-valued function. In this paper, a U-statistic representation for the Kaplan-Meier L-estimator,T(Fn) = xJ(Fn(x))dFn(x), is derived. Furthermore, the representation is also used to establish aBerry-Essen inequality for T(Fn).

  10. THE LAW OF THE ITERATED LOGARITHM OF THE KAPLAN-MEIER INTEGRAL AND ITS APPLICATION

    Institute of Scientific and Technical Information of China (English)

    HE SHUYUAN; WANG YANHUA

    2004-01-01

    For right censored data, the law of the iterated logarithm of the Kaplan-Meier integral is established. As an application, the authors prove the law of the iterated logarithm for weighted least square estimates of randomly censored linear regression model.

  11. Gastric emptying of solids in humans: improved evaluation by Kaplan-Meier plots, with special reference to obesity and gender

    Energy Technology Data Exchange (ETDEWEB)

    Grybaeck, P. [Department of Diagnostic Radiology, Karolinska Hospital, Stockholm (Sweden); Naeslund, E. [Department of Surgery, Karolinska Institute at Danderyd Hospital, Stockholm (Sweden); Hellstroem, P.M. [Department of Internal Medicine, Karolinska Hospital, Stockholm (Sweden); Jacobsson, H. [Department of Diagnostic Radiology, Karolinska Hospital, Stockholm (Sweden)]|[Department of Nuclear Medicine, Karolinska Hospital, Stockholm (Sweden); Backman, L. [Department of Surgery, Karolinska Institute at Danderyd Hospital, Stockholm (Sweden)

    1996-12-01

    It has been suggested that obesity is associated with an altered rate of gastric emptying, and that there are also sex differences in gastric emptying. The results of earlier studies examining gastric emptying rates in obesity and in males and females have proved inconsistent. The aim of this study was to investigate the influence of obesity and gender on gastric emptying, by extending conventional evaluation methods with Kaplan-Meier plots, in order to assess whether these factors have to be accounted for when interpreting results of scintigraphic gastric emptying tests. Twenty-one normal-weight volunteers and nine obese subjects were fed a standardised technetium-99m labelled albumin omelette. Imaging data were acquired at 5- and 10-min intervals in both posterior and anterior projections with the subjects in the sitting position. The half-emptying time, analysed by Kaplan-Meier plot (log-rank test), were shorter in obese subjects compared to normal-weight subjects and later in females compared to males. Also, the lag-phase and half-emptying time were shorter in obese females than in normal females. This study shows an association between different gastric emptying rates and obesity and gender. Therefore, body mass index and gender have to be accounted for when interpreting results of scintigraphic gastric emptying studies. (orig.). With 6 figs., 4 tabs.

  12. KMWin--a convenient tool for graphical presentation of results from Kaplan-Meier survival time analysis.

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    Arnd Gross

    Full Text Available BACKGROUND: Analysis of clinical studies often necessitates multiple graphical representations of the results. Many professional software packages are available for this purpose. Most packages are either only commercially available or hard to use especially if one aims to generate or customize a huge number of similar graphical outputs. We developed a new, freely available software tool called KMWin (Kaplan-Meier for Windows facilitating Kaplan-Meier survival time analysis. KMWin is based on the statistical software environment R and provides an easy to use graphical interface. Survival time data can be supplied as SPSS (sav, SAS export (xpt or text file (dat, which is also a common export format of other applications such as Excel. Figures can directly be exported in any graphical file format supported by R. RESULTS: On the basis of a working example, we demonstrate how to use KMWin and present its main functions. We show how to control the interface, customize the graphical output, and analyse survival time data. A number of comparisons are performed between KMWin and SPSS regarding graphical output, statistical output, data management and development. Although the general functionality of SPSS is larger, KMWin comprises a number of features useful for survival time analysis in clinical trials and other applications. These are for example number of cases and number of cases under risk within the figure or provision of a queue system for repetitive analyses of updated data sets. Moreover, major adjustments of graphical settings can be performed easily on a single window. CONCLUSIONS: We conclude that our tool is well suited and convenient for repetitive analyses of survival time data. It can be used by non-statisticians and provides often used functions as well as functions which are not supplied by standard software packages. The software is routinely applied in several clinical study groups.

  13. Application of Kaplan-Meier analysis in reliability evaluation of products cast from aluminium alloys

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    J. Szymszal

    2010-04-01

    Full Text Available The article evaluates the reliability of AlSi17CuNiMg alloys using Kaplan-Meier-based technique, very popular as a survival estimation tool in medical science. The main object of survival analysis is a group (or groups of units for which the time of occurrence of an event (failure taking place after some time of waiting is estimated. For example, in medicine, the failure can be patient’s death. In this study, the failure was the specimen fracture during a periodical fatigue test, while the survival time was either the test duration to specimen failure (complete observations, or the test end time (censored observations. The parameters of theoretical survival function were estimated with procedures based on the method of least squares, while typical survival time distribution followed either an exponential or two-parameter Weibull distribution. The goodness of fit of a model survival function was estimated with an incremental chi-square test, based on the values of the log likelihood ratio. The effect of alloy processing history on the run of a survival function was examined. The factors shaping the alloy processing history included: mould type (sand or metal mould, alloy modification process, and heat treatment type (solution heat treatment and ageing.

  14. Factors Determining Disease Duration in Alzheimer’s Disease: A Postmortem Study of 103 Cases Using the Kaplan-Meier Estimator and Cox Regression

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    R. A. Armstrong

    2014-01-01

    Full Text Available Factors associated with duration of dementia in a consecutive series of 103 Alzheimer’s disease (AD cases were studied using the Kaplan-Meier estimator and Cox regression analysis (proportional hazard model. Mean disease duration was 7.1 years (range: 6 weeks–30 years, standard deviation = 5.18; 25% of cases died within four years, 50% within 6.9 years, and 75% within 10 years. Familial AD cases (FAD had a longer duration than sporadic cases (SAD, especially cases linked to presenilin (PSEN genes. No significant differences in duration were associated with age, sex, or apolipoprotein E (Apo E genotype. Duration was reduced in cases with arterial hypertension. Cox regression analysis suggested longer duration was associated with an earlier disease onset and increased senile plaque (SP and neurofibrillary tangle (NFT pathology in the orbital gyrus (OrG, CA1 sector of the hippocampus, and nucleus basalis of Meynert (NBM. The data suggest shorter disease duration in SAD and in cases with hypertensive comorbidity. In addition, degree of neuropathology did not influence survival, but spread of SP/NFT pathology into the frontal lobe, hippocampus, and basal forebrain was associated with longer disease duration.

  15. Quantitative estimation of the stability of methicillin-resistant Staphylococcus aureus strain-typing systems by use of Kaplan-Meier survival analysis.

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    O'Sullivan, Matthew V N; Sintchenko, Vitali; Gilbert, Gwendolyn L

    2013-01-01

    Knowledge concerning stability is important in the development and assessment of microbial molecular typing systems and is critical for the interpretation of their results. Typing system stability is usually measured as the fraction of isolates that change type after several in vivo passages, but this does not necessarily reflect in vivo stability. The aim of this study was to utilize survival analysis to provide an informative quantitative measure of in vivo stability and to compare the stabilities of various techniques employed in typing methicillin-resistant Staphylococcus aureus (MRSA). We identified 100 MRSA pairs (isolated from the same patient ≥ 1 month apart) and typed them using multilocus sequence typing (MLST), phage-derived open reading frame (PDORF) typing, toxin gene profiling (TGP), staphylococcal cassette chromosome mec (SCCmec) subtyping, pulsed-field gel electrophoresis (PFGE), and spa sequence typing. Discordant isolate pairs, belonging to different MLST clonal complexes, were excluded, leaving 81 pairs for analysis. The stabilities of these methods were examined using Kaplan-Meier survival analysis, and discriminatory power was measured by Simpson's index of diversity. The probability percentages that the type remained unchanged at 6 months for spa sequence typing, TGP, multilocus variable number of tandem repeats analysis (MLVA), SCCmec subtyping, PDORF typing, and PFGE were 95, 95, 88, 82, 71, and 58, respectively, while the Simpson's indices of diversity were 0.48, 0.47, 0.70, 0.72, 0.89, and 0.88, respectively. Survival analysis using sequential clinical isolates adds an important quantitative dimension to the measurement of stability of a microbial typing system. Of the methods compared here, PDORF typing provides high discriminatory power, comparable with that of PFGE, and a level of stability suitable for MRSA surveillance and outbreak investigations.

  16. Days of Shanghai Stock Index Successive Rises and Fall Based on Kaplan-Meier Algorithms%基于Kaplan-Meier算法的上证指数涨跌天数研究

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    毕建欣

    2011-01-01

    运用Kaplan-Meier算法对上证指数连续上涨和下跌天数进行研究,研究了在不同的市场交易制度(即T+0,T+1和涨停板制度)对上证指数涨跌天数的影响,其结果表明Kaplan-Meier算法对于分析股市的变动是有效的.%In this paper, Days of Shanghai Stock Index Successive rises and fall are analyzed by Kaplan-Meier Algorithms. It demonstrates the policy effect on days of Shanghai Stock Index successive rises and fall , such as" T + 0","T + 1"and"soaring deadline system". It also reveals that Kaplan-Meier Algorithms is valid for analyzing the changes of the stock market.

  17. Hazard Rate Estimation for Censored Data via Strong Representation of the Kaplan-Meier Estimator.

    Science.gov (United States)

    1985-08-01

    of bounded variation (condition (k4).) The process( /n 1 has mean zero and covariance SA t (26) r(s,t) E E[C(s) C(t)] - F(s) F(t) f [(u)]- 2 d Lj(u...continuous with density f(x) > 0 at x. Suppose k is of bounded variation and is continuous. Then fn(x) admits the strong approximation on the interval [0,T

  18. Improved curve fits to summary survival data: application to economic evaluation of health technologies

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    Henley William

    2011-10-01

    Full Text Available Abstract Background Mean costs and quality-adjusted-life-years are central to the cost-effectiveness of health technologies. They are often calculated from time to event curves such as for overall survival and progression-free survival. Ideally, estimates should be obtained from fitting an appropriate parametric model to individual patient data. However, such data are usually not available to independent researchers. Instead, it is common to fit curves to summary Kaplan-Meier graphs, either by regression or by least squares. Here, a more accurate method of fitting survival curves to summary survival data is described. Methods First, the underlying individual patient data are estimated from the numbers of patients at risk (or other published information and from the Kaplan-Meier graph. The survival curve can then be fit by maximum likelihood estimation or other suitable approach applied to the estimated individual patient data. The accuracy of the proposed method was compared against that of the regression and least squares methods and the use of the actual individual patient data by simulating the survival of patients in many thousands of trials. The cost-effectiveness of sunitinib versus interferon-alpha for metastatic renal cell carcinoma, as recently calculated for NICE in the UK, is reassessed under several methods, including the proposed method. Results Simulation shows that the proposed method gives more accurate curve fits than the traditional methods under realistic scenarios. Furthermore, the proposed method achieves similar bias and mean square error when estimating the mean survival time to that achieved by analysis of the complete underlying individual patient data. The proposed method also naturally yields estimates of the uncertainty in curve fits, which are not available using the traditional methods. The cost-effectiveness of sunitinib versus interferon-alpha is substantially altered when the proposed method is used. Conclusions

  19. Cortical hypertrophy with a short, curved uncemented hip stem does not have any clinical impact during early follow-up.

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    Maier, Michael W; Streit, Marcus R; Innmann, Moritz M; Krüger, Marlis; Nadorf, Jan; Kretzer, J Philippe; Ewerbeck, Volker; Gotterbarm, Tobias

    2015-12-01

    Short stems have become more and more popular for cementless total hip arthroplasty in the past few years. While conventional, uncemented straight stems for primary total hip arthroplasty (THA) have shown high survival rates in the long term, it is not known whether uncemented short stems represent a reasonable alternative. As cortical hypertrophy has been reported for short stems, the aim of this study was to determine the radiographic prevalence of cortical hypertrophy and to assess the clinical outcome of a frequently used short, curved hip stem. We retrospectively studied the clinical and radiographic results of our first 100 consecutive THAs (97 patients) using the Fitmore® hip stem. Mean age at the time of index arthroplasty was 59 years (range, 19 - 79 years). Clinical outcome and radiographic results were assessed with a minimum follow-up of 2 years, and Kaplan-Meier survivorship analysis was used to estimate survival for different endpoints. After a mean follow-up of 3.3 years (range, 2.0 - 4.4 years), two patients (two hips) had died, and three patients (four hips) were lost to follow-up. Kaplan-Meier analysis estimated a survival rate of 100 % at 3.8 years, with revision for any reason as the endpoint. No femoral component showed radiographic signs of loosening. No osteolysis was detected. Cortical hypertrophy was found in 50 hips (63 %), predominantly in Gruen zone 3 and 5. In the cortical hypertrophy group, two patients (two hips; 4 %) reported some thigh pain in combination with pain over the greater trochanter region during physical exercise (UCLA Score 6 and 7). There was no significant difference concerning the clinical outcome between the cortical hypertrophy and no cortical hypertrophy group. The survival rate and both clinical and the radiographic outcome confirm the encouraging results for short, curved uncemented stems. Postoperative radiographs frequently displayed cortical hypertrophy but it had no significant effect on the

  20. SHOWING THE THYRISTOR AND TRIAC HARMONICS IN 3D SPACE AND CURVE FITTING TO THD

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    Ahmet ALTINTAŞ

    2004-03-01

    Full Text Available The switching equipment, like thyristors and triacs, are widely used power electronics. Also, they have nonlinear load characteristics and produce effective harmonics. In order to compensate harmonic currents of nonlinear loads, THD value and the amplitude of harmonics produced from loads at the working conditions should be known. Also, this process is only possible with harmonic analysis. Harmonic analysis is expensive process because of demanding special equipment. In this study, by expressing harmonics, produced thyristor and triac with different load and firing angle, in 3D space, a new viewing point to show harmonic analysis was presented; with curve fitting to the THD values at the each firing angle, polynomials were obtained; by doing so, THD values will be directly found without harmonic analysis.

  1. Light saturation curves show competence of the water splitting complex in inactive Photosystem II reaction centers.

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    Nedbal, L; Gibas, C; Whitmarsh, J

    1991-12-01

    Photosystem II complexes of higher plants are structurally and functionally heterogeneous. While the only clearly defined structural difference is that Photosystem II reaction centers are served by two distinct antenna sizes, several types of functional heterogeneity have been demonstrated. Among these is the observation that in dark-adapted leaves of spinach and pea, over 30% of the Photosystem II reaction centers are unable to reduce plastoquinone to plastoquinol at physiologically meaningful rates. Several lines of evidence show that the impaired reaction centers are effectively inactive, because the rate of oxidation of the primary quinone acceptor, QA, is 1000 times slower than in normally active reaction centers. However, there are conflicting opinions and data over whether inactive Photosystem II complexes are capable of oxidizing water in the presence of certain artificial electron acceptors. In the present study we investigated whether inactive Photosystem II complexes have a functional water oxidizing system in spinach thylakoid membranes by measuring the flash yield of water oxidation products as a function of flash intensity. At low flash energies (less that 10% saturation), selected to minimize double turnovers of reaction centers, we found that in the presence of the artificial quinone acceptor, dichlorobenzoquinone (DCBQ), the yield of proton release was enhanced 20±2% over that observed in the presence of dimethylbenzoquinone (DMBQ). We argue that the extra proton release is from the normally inactive Photosystem II reaction centers that have been activated in the presence of DCBQ, demonstrating their capacity to oxidize water in repetitive flashes, as concluded by Graan and Ort (Biochim Biophys Acta (1986) 852: 320-330). The light saturation curves indicate that the effective antenna size of inactive reaction centers is 55±12% the size of active Photosystem II centers. Comparison of the light saturation dependence of steady state oxygen evolution

  2. Plant Photosynthesis-Irradiance Curve Responses to Pollution Show Non-Competitive Inhibited Michaelis Kinetics.

    Science.gov (United States)

    Lin, Maozi; Wang, Zhiwei; He, Lingchao; Xu, Kang; Cheng, Dongliang; Wang, Genxuan

    2015-01-01

    Photosynthesis-irradiance (PI) curves are extensively used in field and laboratory research to evaluate the photon-use efficiency of plants. However, most existing models for PI curves focus on the relationship between the photosynthetic rate (Pn) and photosynthetically active radiation (PAR), and do not take account of the influence of environmental factors on the curve. In the present study, we used a new non-competitive inhibited Michaelis-Menten model (NIMM) to predict the co-variation of Pn, PAR, and the relative pollution index (I). We then evaluated the model with published data and our own experimental data. The results indicate that the Pn of plants decreased with increasing I in the environment and, as predicted, were all fitted well by the NIMM model. Therefore, our model provides a robust basis to evaluate and understand the influence of environmental pollution on plant photosynthesis.

  3. Plant Photosynthesis-Irradiance Curve Responses to Pollution Show Non-Competitive Inhibited Michaelis Kinetics.

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    Maozi Lin

    Full Text Available Photosynthesis-irradiance (PI curves are extensively used in field and laboratory research to evaluate the photon-use efficiency of plants. However, most existing models for PI curves focus on the relationship between the photosynthetic rate (Pn and photosynthetically active radiation (PAR, and do not take account of the influence of environmental factors on the curve. In the present study, we used a new non-competitive inhibited Michaelis-Menten model (NIMM to predict the co-variation of Pn, PAR, and the relative pollution index (I. We then evaluated the model with published data and our own experimental data. The results indicate that the Pn of plants decreased with increasing I in the environment and, as predicted, were all fitted well by the NIMM model. Therefore, our model provides a robust basis to evaluate and understand the influence of environmental pollution on plant photosynthesis.

  4. ASAS-SN Optical Light Curve of Swift J0243.6+6124 Shows Long Term Variability

    Science.gov (United States)

    Stanek, K. Z.; Kochanek, C. S.; Thompson, T. A.; Shappee, B. J.; Holoien, T. W.-S.; Prieto, J. L.; Dong, Subo

    2017-10-01

    Swift J0243.6+6124 (GCN #21960) has been localized (ATel #10809) to likely coincide with B=13 star USNO-B1.0 1514-0083050. Given the statement in ATel #10809 of "no statistically strong evidence of optical variability," we used ASAS-SN Sky Patrol public all-sky light curve interface (Kochanek et al. 2017) to retrieve 1000+ days light curve at the position of USNO-B1.0 1514-0083050.

  5. HD 240121 - An ACV variable showing anti-phase variations of the B and V light curves

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    Gröbel, Rainer; Hümmerich, Stefan; Paunzen, Ernst; Bernhard, Klaus

    2017-01-01

    The variability of HD 240121 = BD+59 2602 was first suspected by Särg and Wramdemark (1970) and later confirmed by Gröbel R. (1992a,b). Because of the observed anti-phase variations of the B and V light curves, the latter author tentatively suggested an ACV type. Apart from its inclusion in the catalog of New Suspected Variables (NSV 25977), no further investigations of the star have been published. HD 240121 was included into our target list of ACV candidates and investigated in order to determine the reason for the observed brightness variations. All available information on HD 240121 were collected via an exhaustive data mining procedure. Data from Gröbel (1992a,b) were re-analysed and photometric observations from the NSVS and Hipparcos archives were procured and investigated. Line-of-sight reddening and stellar parameters were calculated from archival photometric data. HD 240121 is a young, late B-type CP2 star of the silicon subgroup. The observed period, amplitude of light variations and variability pattern (anti-phase variations) are typical of ACV variables. The occurrence of anti-phase variations of the B and V light curves is rarely observed and points to the existence of a null wavelength in the visual spectrum. We therefore strongly encourage further multi-colour photometric observations of this star.

  6. HD 240121 - an ACV variable showing anti-phase variations of the B and V light curves

    CERN Document Server

    Gröbel, Rainer; Paunzen, Ernst; Bernhard, Klaus

    2016-01-01

    The variability of HD 240121 = BD+59 2602 was first suspected by S\\"arg & Wramdemark (1970) and later confirmed by Gr\\"obel (1992a,b). Because of the observed anti-phase variations of the B and V light curves, the latter author tentatively suggested an ACV type. Apart from its inclusion in the catalog of New Suspected Variables (NSV 25977), no further investigations of the star have been published. HD 240121 was included into our target list of ACV candidates and investigated in order to determine the reason for the observed brightness variations. All available information on HD 240121 were collected via an exhaustive data mining procedure. Data from Gr\\"obel (1992a,b) were re-analysed and photometric observations from the NSVS and Hipparcos archives were procured and investigated. Line-of-sight reddening and stellar parameters were calculated from archival photometric data. HD 240121 is a young, late B-type CP2 star of the silicon subgroup. The observed period, amplitude of light variations and variabili...

  7. ASAS-SN optical light-curve of blazar TXS 0506+056, located inside the IceCube-170922A error region, shows increased optical activity

    Science.gov (United States)

    Franckowiak, A.; Stanek, K. Z.; Kochanek, C. S.; Thompson, T. A.; Holoien, T. W.-S.; Shappee, B. J.; Prieto, J. L.; Dong, Subo

    2017-09-01

    Archival ASAS-SN (Shappee et al. 2014) data show an increased optical activity of the blazar TXS 0506+056, which is located inside the error region of the high-energy neutrino candidate IceCube-170922A, and was found to be in a flaring state by Fermi-LAT (ATel #10791), and it was also observed by Swift Using ASAS-SN Sky Patrol public all-sky light curve interface (Kochanek et al. 2017), we retrieved 200-day light curve of TXS 0506+056, showing a rise of 0.5 mag in V-band over the last 50 days.

  8. Bias and precision of methods for estimating the difference in restricted mean survival time from an individual patient data meta-analysis

    Directory of Open Access Journals (Sweden)

    Béranger Lueza

    2016-03-01

    Full Text Available Abstract Background The difference in restricted mean survival time ( rmstD t ∗ $$ rmstD\\left({t}^{\\ast}\\right $$ , the area between two survival curves up to time horizon t ∗ $$ {t}^{\\ast } $$ , is often used in cost-effectiveness analyses to estimate the treatment effect in randomized controlled trials. A challenge in individual patient data (IPD meta-analyses is to account for the trial effect. We aimed at comparing different methods to estimate the rmstD t ∗ $$ rmstD\\left({t}^{\\ast}\\right $$ from an IPD meta-analysis. Methods We compared four methods: the area between Kaplan-Meier curves (experimental vs. control arm ignoring the trial effect (Naïve Kaplan-Meier; the area between Peto curves computed at quintiles of event times (Peto-quintile; the weighted average of the areas between either trial-specific Kaplan-Meier curves (Pooled Kaplan-Meier or trial-specific exponential curves (Pooled Exponential. In a simulation study, we varied the between-trial heterogeneity for the baseline hazard and for the treatment effect (possibly correlated, the overall treatment effect, the time horizon t ∗ $$ {t}^{\\ast } $$ , the number of trials and of patients, the use of fixed or DerSimonian-Laird random effects model, and the proportionality of hazards. We compared the methods in terms of bias, empirical and average standard errors. We used IPD from the Meta-Analysis of Chemotherapy in Nasopharynx Carcinoma (MAC-NPC and its updated version MAC-NPC2 for illustration that included respectively 1,975 and 5,028 patients in 11 and 23 comparisons. Results The Naïve Kaplan-Meier method was unbiased, whereas the Pooled Exponential and, to a much lesser extent, the Pooled Kaplan-Meier methods showed a bias with non-proportional hazards. The Peto-quintile method underestimated the rmstD t ∗ $$ rmstD\\left({t}^{\\ast}\\right $$ , except with non-proportional hazards at t ∗ $$ {t}^{\\ast } $$ = 5 years. In the presence of treatment effect

  9. In silico sampling reveals the effect of clustering and shows that the log-normal rank abundance curve is an artefact

    NARCIS (Netherlands)

    Neuteboom, J.H.; Struik, P.C.

    2005-01-01

    The impact of clustering on rank abundance, species-individual (S-N)and species-area curves was investigated using a computer programme for in silico sampling. In a rank abundance curve the abundances of species are plotted on log-scale against species sequence. In an S-N curve the number of species

  10. Simultaneous development of laparoscopy and robotics provides acceptable perioperative outcomes and shows robotics to have a faster learning curve and to be overall faster in rectal cancer surgery: analysis of novice MIS surgeon learning curves.

    Science.gov (United States)

    Melich, George; Hong, Young Ki; Kim, Jieun; Hur, Hyuk; Baik, Seung Hyuk; Kim, Nam Kyu; Sender Liberman, A; Min, Byung Soh

    2015-03-01

    Laparoscopy offers some evidence of benefit compared to open rectal surgery. Robotic rectal surgery is evolving into an accepted approach. The objective was to analyze and compare laparoscopic and robotic rectal surgery learning curves with respect to operative times and perioperative outcomes for a novice minimally invasive colorectal surgeon. One hundred and six laparoscopic and 92 robotic LAR rectal surgery cases were analyzed. All surgeries were performed by a surgeon who was primarily trained in open rectal surgery. Patient characteristics and perioperative outcomes were analyzed. Operative time and CUSUM plots were used for evaluating the learning curve for laparoscopic versus robotic LAR. Laparoscopic versus robotic LAR outcomes feature initial group operative times of 308 (291-325) min versus 397 (373-420) min and last group times of 220 (212-229) min versus 204 (196-211) min-reversed in favor of robotics; major complications of 4.7 versus 6.5 % (NS), resection margin involvement of 2.8 versus 4.4 % (NS), conversion rate of 3.8 versus 1.1 (NS), lymph node harvest of 16.3 versus 17.2 (NS), and estimated blood loss of 231 versus 201 cc (NS). Due to faster learning curves for extracorporeal phase and total mesorectal excision phase, the robotic surgery was observed to be faster than laparoscopic surgery after the initial 41 cases. CUSUM plots demonstrate acceptable perioperative surgical outcomes from the beginning of the study. Initial robotic operative times improved with practice rapidly and eventually became faster than those for laparoscopy. Developing both laparoscopic and robotic skills simultaneously can provide acceptable perioperative outcomes in rectal surgery. It might be suggested that in the current milieu of clashing interests between evolving technology and economic constrains, there might be advantages in embracing both approaches.

  11. Actuarial and actual analysis of surgical results: empirical validation.

    Science.gov (United States)

    Grunkemeier, G L; Anderson, R P; Starr, A

    2001-06-01

    This report validates the use of the Kaplan-Meier (actuarial) method of computing survival curves by comparing 12-year estimates published in 1978 with current assessments. It also contrasts cumulative incidence curves, referred to as "actual" analysis in the cardiac-related literature with Kaplan-Meier curves for thromboembolism and demonstrates that with the former estimate the percentage of events that will actually occur.

  12. Comparison of Surgical Parameters and Results between Curved Varus Osteotomy and Rotational Osteotomy for Osteonecrosis of the Femoral Head.

    Science.gov (United States)

    Lee, Young-Kyun; Park, Chan Ho; Ha, Yong-Chan; Kim, Do-Yeon; Lyu, Sung-Hwa; Koo, Kyung-Hoi

    2017-06-01

    Various osteotomies have been introduced to treat osteonecrosis of the femoral head. The purpose of this study was to compare surgical parameters, postoperative limb length discrepancy, and minimum 5-year clinical and radiological results between transtrochanteric curved varus osteotomy (TCVO) and transtrochanteric rotational osteotomy (TRO) for osteonecrosis of the femoral head. From 2004 to 2009, 103 consecutive TROs (97 patients) followed by 72 consecutive TCVOs (64 patients) were performed for the treatment of osteonecrosis of the femoral head. Of these, 85 patients (91 hips) in the TRO group and 58 patients (65 hips) in the TCVO group completed minimum 5-year clinical and radiological follow-up. The Kaplan-Meier product-limit method was used to estimate survival. The TCVO group had shorter operation time (p TRO group and 7 hips (10.8%) in the TCVO group (p = 0.007). Osteophyte formation was observed in 34 hips (37.4%) in the TRO group and 13 hips (20%) in the TCVO group (p = 0.020). Fifteen hips (16.5%) in the TRO group and 7 hips (10.8%) in the TCVO group underwent conversion total hip arthroplasty (THA). The survival rate at 9 years with radiographic collapse as the endpoint was 68.7% (95% confidence interval [CI], 58.1% to 79.3%) in the TRO group, and 84.7% (95% CI, 71.5% to 97.9%) in the TCVO group. With conversion to THA as the endpoint, the survival rate was 82.2% (95% CI, 73.1% to 91.3%) in the TRO group and 89.2% (95% CI, 81.7% to 96.7%) in the TCVO group. The comparison indicates that TCVO was better than TRO in terms of surgical parameters including operation time and estimated blood loss while the 9-year survival rates were similar.

  13. Elevated plasma fibrinogen level shows superior prognostic value than Epstein-Barr virus DNA load for stage IVA/B nasopharyngeal carcinoma patients in the intensity-modulated radiotherapy era.

    Science.gov (United States)

    Lan, Mei; Chen, Chunyan; Huang, Ying; Mao, Minjie; Han, Fei; Liao, Junfang; Deng, Meiling; Duan, Zhijun; Zheng, Lie; Wu, Shaoxiong; Lu, Taixiang; Jian, Yutao

    2016-07-19

    Effective prognostic factors for patients with stage IVA/B nasopharyngeal carcinoma (NPC) who are susceptible to distant metastases are limited. We aim to investigate the prognostic value of pretreatment plasma fibrinogen (FIB) level and Epstein-Barr virus DNA (EBV-DNA) load in these patients in the era of intensity-modulated radiotherapy (IMRT). The 5-year DSS, DFS and DMFS rates of the entire cohort were 72.7%, 66.8%, 80.0%, respectively. High FIB level was identified as a negative prognostic factor for survival: the 5-year DSS, DFS and DMFS rates for patients with high FIB (> 4.0 g/L) and normal FIB (≤ 4.0 g/L) were 60.3% vs. 76.0%, 56.0% vs. 69.9%, and 59.4% vs. 85.5%, respectively (all P level shows superior prognostic value than EBV-DNA load for stage IVA/B NPC patients in the era of IMRT. A total of 755 patients with newly-diagnosed stage IVA/B NPC treated with definitive IMRT between January 2007 and December 2011 were enrolled. Plasma FIB and EBV-DNA were measured before treatment. Disease-specific survival (DSS), disease-free survival (DFS) and distant metastasis-free survival (DMFS) were calculated using the Kaplan-Meier method; differences were compared using the log-rank test.

  14. Pencils on real curves

    CERN Document Server

    Coppens, Marc

    2011-01-01

    We consider coverings of real algebraic curves to real rational algebraic curves. We show the existence of such coverings having prescribed topological degree on the real locus. From those existence results we prove some results on Brill-Noether Theory for pencils on real curves. For coverings having topological degree 0 we introduce the covering number k and we prove the existence of coverings of degree 4 with prescribed covering number.

  15. Tornado-Shaped Curves

    Science.gov (United States)

    Martínez, Sol Sáez; de la Rosa, Félix Martínez; Rojas, Sergio

    2017-01-01

    In Advanced Calculus, our students wonder if it is possible to graphically represent a tornado by means of a three-dimensional curve. In this paper, we show it is possible by providing the parametric equations of such tornado-shaped curves.

  16. Effectiveness and safety of apixaban versus warfarin in non-valvular atrial fibrillation patients in "real-world" clinical practice

    DEFF Research Database (Denmark)

    Li, Xiaoyan; Deitelzweig, Steve; Keshishian, Allison

    2017-01-01

    ) of NVAF patients newly initiating apixaban or warfarin from January 1, 2013 to September 30, 2015. After 1:1 warfarin-apixaban propensity score matching (PSM) within each database, the resulting patient records were pooled. Kaplan-Meier curves and Cox proportional hazards models were used to estimate...... to warfarin treatment. This is the largest "real-world" study on apixaban effectiveness and safety to date, showing that apixaban initiation was associated with significant risk reductions in stroke/SE and major bleeding compared to warfarin initiation after PSM. These benefits were consistent across various...

  17. The Epidemiology of Bartonellosis in Peru

    Science.gov (United States)

    2000-12-19

    CHAPTER 3. Figure 1. Kaplan-Meier Survival Plot of hematic-phase bartonellosis 102 patients developing verrucous lesions Figure 2. TIme-line showing...onset of verrucous lesions in patients with 103 Hematic bartonellosis following treatment Figure 3. Kaplan-Meier Survival Pfot of ~nset of verrucous ...of bartonellosis in endemic areas, reports of aggressive verrucous bartonellosis from the western coastal desert region of Ecuador, emergence of the

  18. Large Curved Surface Measurement

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    The measurement principle of large curved surface through theodolite industry survey system is introduced. Two methods are suggested with respect to the distribution range of curved surface error. The experiments show that the measurement precision can be up to 0.15mm with relative precision of 3×10-5. Finally, something needed paying attention to and the application aspects on theodolite industry survey system are given.

  19. Counting curves on surfaces

    OpenAIRE

    2015-01-01

    In this paper we consider an elementary, and largely unexplored, combinatorial problem in low-dimensional topology. Consider a real 2-dimensional compact surface $S$, and fix a number of points $F$ on its boundary. We ask: how many configurations of disjoint arcs are there on $S$ whose boundary is $F$? We find that this enumerative problem, counting curves on surfaces, has a rich structure. For instance, we show that the curve counts obey an effective recursion, in the general framework of to...

  20. Highly curved microchannel plates

    Science.gov (United States)

    Siegmund, O. H. W.; Cully, S.; Warren, J.; Gaines, G. A.; Priedhorsky, W.; Bloch, J.

    1990-01-01

    Several spherically curved microchannel plate (MCP) stack configurations were studied as part of an ongoing astrophysical detector development program, and as part of the development of the ALEXIS satellite payload. MCP pairs with surface radii of curvature as small as 7 cm, and diameters up to 46 mm have been evaluated. The experiments show that the gain (greater than 1.5 x 10 exp 7) and background characteristics (about 0.5 events/sq cm per sec) of highly curved MCP stacks are in general equivalent to the performance achieved with flat MCP stacks of similar configuration. However, gain variations across the curved MCP's due to variations in the channel length to diameter ratio are observed. The overall pulse height distribution of a highly curved surface MCP stack (greater than 50 percent FWHM) is thus broader than its flat counterpart (less than 30 percent). Preconditioning of curved MCP stacks gives comparable results to flat MCP stacks, but it also decreases the overall gain variations. Flat fields of curved MCP stacks have the same general characteristics as flat MCP stacks.

  1. Show Time

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    <正> Story: Show Time!The whole class presents the story"Under the Sea".Everyone is so excited and happy.Both Leo and Kathy show their parentsthe characters of the play."Who’s he?"asks Kathy’s mom."He’s the prince."Kathy replies."Who’s she?"asks Leo’s dad."She’s the queen."Leo replieswith a smile.

  2. Snobbish Show

    Institute of Scientific and Technical Information of China (English)

    YIN PUMIN

    2010-01-01

    @@ The State Administration of Radio,Film and Television (SARFT),China's media watchdog,issued a new set of mles on June 9 that strictly regulate TV match-making shows,which have been sweeping the country's primetime programming. "Improper social and love values such as money worship should not be presented in these shows.Humiliation,verbal attacks and sex-implied vulgar content are not allowed" the new roles said.

  3. Investigation of standardized administration of anti-platelet drugs and its effect on the prognosis of patients with coronary heart disease.

    Science.gov (United States)

    Ding, Chao; Zhang, Jianhua; Li, Rongcheng; Wang, Jiacai; Hu, Yongcang; Chen, Yanyan; Li, Xiannan; Xu, Yan

    2017-10-01

    The aim of the present study was to explore the effect of adherence to standardized administration of anti-platelet drugs on the prognosis of patients with coronary heart disease. A total of 144 patients newly diagnosed with coronary heart disease at Lu'an Shili Hospital of Anhui Province (Lu'an, China) between June 2010 and June 2012 were followed up. Kaplan-Meier curves and the Cox regression model were used to evaluate the effects of standardized administration of anti-platelet drugs on primary and secondary end-point events. Of the patients with coronary heart disease, 109 (76%) patients took standard anti-platelet drugs following discharge. Kaplan-Meier curve and Cox regression analysis showed that standardized administration of anti-platelet drugs reduced the risk of primary end-point events (including all-cause mortality, non-lethal myocardial infarction and stroke) of patients with coronary heart disease [hazard ratio (HR)=0.307; 95% confidence interval (CI): 0.099-0.953; P=0.041) and all-cause mortality (HR=0.162; 95% CI: 0.029-0.890; P=0.036); however, standardized administration had no predictive value with regard to secondary end-point events. Standardized administration of anti-platelet drugs obviously reduced the risk of primary end-point events in patients with coronary heart disease, and further analysis showed that only all-cause mortality exhibited a statistically significant reduction.

  4. EROBATIC SHOW

    Institute of Scientific and Technical Information of China (English)

    2016-01-01

    Visitors look at plane models of the Commercial Aircraft Corp. of China, developer of the count,s first homegrown large passenger jet C919, during the Singapore Airshow on February 16. The biennial event is the largest airshow in Asia and one of the most important aviation and defense shows worldwide. A number of Chinese companies took part in the event during which Okay Airways, the first privately owned aidine in China, signed a deal to acquire 12 Boeing 737 jets.

  5. Moduli of Trigonal Curves

    CERN Document Server

    Stankova-Frenkel, Z E

    1997-01-01

    We study the moduli of trigonal curves. We establish the exact upper bound of ${36(g+1)}/(5g+1)$ for the slope of trigonal fibrations. Here, the slope of any fibration $X\\to B$ of stable curves with smooth general member is the ratio Hodge class $\\lambda$ on the moduli space $\\bar{\\mathfrak{M}}_g$ to the base $B$. We associate to a trigonal family $X$ a canonical rank two vector bundle $V$, and show that for Bogomolov-semistable $V$ the slope satisfies the stronger inequality ${\\delta_B}/{\\lambda_B}\\leq 7+{6}/{g}$. We further describe the rational Picard group of the {trigonal} locus $\\bar{\\mathfrak T}_g$ in the moduli space $\\bar{\\mathfrak{M}}_g$ of genus $g$ curves. In the even genus case, we interpret the above Bogomolov semistability condition in terms of the so-called Maroni divisor in $\\bar{\\mathfrak T}_g$.

  6. Archimedes Curves

    Science.gov (United States)

    Swain, Gordon A.

    2013-01-01

    We show that inside every triangle the locus of points satisfying a natural proportionality relationship is a parabola and go on to describe how this triangle-parabola relationship was used by Archimedes to find the area between a line and a parabola.

  7. Archimedes Curves

    Science.gov (United States)

    Swain, Gordon A.

    2013-01-01

    We show that inside every triangle the locus of points satisfying a natural proportionality relationship is a parabola and go on to describe how this triangle-parabola relationship was used by Archimedes to find the area between a line and a parabola.

  8. Influence of surrounding wall thickness on the fatigue resistance of molars restored with ceramic inlay

    Directory of Open Access Journals (Sweden)

    Shizuma Shibata

    2014-06-01

    Full Text Available The purpose of this study was to evaluate the influence of buccal and lingual wall thickness on the fatigue resistance of molars restored with CAD/CAM ceramic inlays. Forty human third molars were selected and divided into 4 groups, according to the remaining surrounding wall thickness chosen for inlay preparation (n = 10: G1, 2.0 mm; G2, 1.5 mm; G3, 1.0 mm; G4, 0.5 mm. All inlays were made from feldspathic ceramic blocks by a CAD/CAM system, and cemented adhesively. After 1 week stored in distilled water at 37 °C, the specimens were subjected to fatigue testing under the following protocol: 5Hz; pre-load of 200 N for 5,000 cycles, followed by increasing loads of 400, 600, 800, 1000, 1200 and 1400 N for 30,000 cycles each. The specimens were cycled until failure or completion of 185,000 cycles. The survival rate of the groups was compared using the Kaplan-Meier survival curves (p > 0.05. All specimens withstood the fatigue protocol (185,000 cycles, representing a 100% survival rate. The Kaplan-Meier survival curves showed no difference between groups. It can be concluded that the remaining tooth wall thickness did not influence the fatigue resistance of molars restored with CAD/CAM ceramic inlays.

  9. A randomized controlled trial of various MTA materials for partial pulpotomy in permanent teeth.

    Science.gov (United States)

    Kang, Chung-Min; Sun, Yeji; Song, Je Seon; Pang, Nan-Sim; Roh, Byoung-Duck; Lee, Chan-Young; Shin, Yooseok

    2017-05-01

    The aim of this study was to evaluate and compare the clinical applicability of various MTA materials as partial pulpotomy materials in permanent teeth. Partial pulpotomy was performed on 104 permanent teeth from 82 people (mean 29.3±14.8years old), who met the inclusion criteria in randomized clinical trial. The teeth were divided into three groups: ProRoot MTA (n=33), OrthoMTA (n=36), RetroMTA (n=35). Clinical examination and radiographic comparison were carried out at 1, 3, 6 and 12 months after the treatment. Survival analysis was performed using the Kaplan-Meier survival curves and log rank tests. Partial pulpotomy sustained a high success rate up to 1year with no significant differences in the outcomes treated with three MTA materials: ProRoot MTA, 96.0%; OrthoMTA, 92.8%; RetroMTA, 96.0%. The Kaplan-Meier survival function curves showed no significant differences among three groups concerning clinical and radiographic cumulative survival rates. In addition, no potential prognostic factors related to the success rate of partial pulpotomy among age, sex, tooth type, root apex status, the site and type of pulp exposure, and the type of restoration were observed in log rank analysis. Partial pulpotomy with ProRoot MTA, OrthoMTA and RetroMTA had favorable results and clinical and radiographic results were not significantly different in three groups after 1year. Copyright © 2016 Elsevier Ltd. All rights reserved.

  10. Influence of surrounding wall thickness on the fatigue resistance of molars restored with ceramic inlay.

    Science.gov (United States)

    Shibata, Shizuma; Gondo, Renata; Araújo, Élito; Mello Roesler, Carlos Rodrigo de; Baratieri, Luiz Narciso

    2014-01-01

    The purpose of this study was to evaluate the influence of buccal and lingual wall thickness on the fatigue resistance of molars restored with CAD/CAM ceramic inlays. Forty human third molars were selected and divided into 4 groups, according to the remaining surrounding wall thickness chosen for inlay preparation (n=10): G1, 2.0 mm; G2, 1.5 mm; G3, 1.0 mm; G4, 0.5 mm. All inlays were made from feldspathic ceramic blocks by a CAD/CAM system, and cemented adhesively. After 1 week stored in distilled water at 37 °C, the specimens were subjected to fatigue testing under the following protocol: 5Hz; pre-load of 200 N for 5,000 cycles, followed by increasing loads of 400, 600, 800, 1000, 1200 and 1400 N for 30,000 cycles each. The specimens were cycled until failure or completion of 185,000 cycles. The survival rate of the groups was compared using the Kaplan-Meier survival curves (p>0.05). All specimens withstood the fatigue protocol (185,000 cycles), representing a 100% survival rate. The Kaplan-Meier survival curves showed no difference between groups. It can be concluded that the remaining tooth wall thickness did not influence the fatigue resistance of molars restored with CAD/CAM ceramic inlays.

  11. The value of the 2005 International Society of Urological Pathology (ISUP) modified Gleason grading system as a predictor of biochemical recurrence after radical prostatectomy.

    Science.gov (United States)

    Billis, Athanase; Quintal, Maisa M Q; Meirelles, Luciana; Freitas, Leandro L L; Costa, Larissa B E; Bonfitto, João F L; Diniz, Betina L; Poletto, Paola H; Magna, Luís A; Ferreira, Ubirajara

    2014-05-01

    To compare time and risk to biochemical recurrence (BR) after radical prostatectomy of two chronologically different groups of patients using the standard and the modified Gleason system (MGS). Cohort 1 comprised biopsies of 197 patients graded according to the standard Gleason system (SGS) in the period 1997/2004, and cohort 2, 176 biopsies graded according to the modified system in the period 2005/2011. Time to BR was analyzed with the Kaplan-Meier product-limit analysis and prediction of shorter time to recurrence using univariate and multivariate Cox proportional hazards model. Patients in cohort 2 reflected time-related changes: striking increase in clinical stage T1c, systematic use of extended biopsies, and lower percentage of total length of cancer in millimeter in all cores. The MGS used in cohort 2 showed fewer biopsies with Gleason score ≤ 6 and more biopsies of the intermediate Gleason score 7. Time to BR using the Kaplan-Meier curves showed statistical significance using the MGS in cohort 2, but not the SGS in cohort 1. Only the MGS predicted shorter time to BR on univariate analysis and on multivariate analysis was an independent predictor. The results favor that the 2005 International Society of Urological Pathology modified system is a refinement of the Gleason grading and valuable for contemporary clinical practice.

  12. Glioblastoma: does the pre-treatment geometry matter? A postcontrast T1 MRI-based study

    Energy Technology Data Exchange (ETDEWEB)

    Perez-Beteta, Julian; Martinez-Gonzalez, Alicia; Molina, David; Amo-Salas, Mariano; Luque, Belen; Perez-Garcia, Victor M. [Universidad de Castilla-La Mancha, Laboratory of Mathematical Oncology, Edificio Politecnico, Instituto de Matematica Aplicada a la Ciencia y la Ingenieria, Ciudad Real (Spain); Arregui, Elena; Calvo, Manuel; Borras, Jose M.; Lopez, Carlos; Claramonte, Marta [Hospital General de Ciudad Real, Ciudad Real (Spain); Barcia, Juan A.; Iglesias, Lidia; Avecillas, Josue [Hospital Clinico San Carlos, Madrid (Spain); Albillo, David; Navarro, Miguel; Villanueva, Jose M.; Paniagua, Juan C.; Perez-Romasanta, Luis [Hospital Universitario de Salamanca, Salamanca (Spain); Martino, Juan; Velasquez, Carlos [Hospital Marques de Valdecilla, Santander (Spain); Asenjo, Beatriz; Benavides, Manuel; Herruzo, Ismael [Hospital Carlos Haya, Malaga (Spain); Delgado, Maria del Carmen; Valle, Ana del [Universidad de Sevilla, Facultad de Matematicas, Sevilla (Spain); Falkov, Anthony [Auckland Radiation Oncology, Auckland (New Zealand); Schucht, Philippe [Bern Inselspital, Neurosurgery Department, Bern (Switzerland); Arana, Estanislao [Instituto Valenciano de Oncologia, Valencia (Spain)

    2017-03-15

    The potential of a tumour's volumetric measures obtained from pretreatment MRI sequences of glioblastoma (GBM) patients as predictors of clinical outcome has been controversial. Mathematical models of GBM growth have suggested a relation between a tumour's geometry and its aggressiveness. A multicenter retrospective clinical study was designed to study volumetric and geometrical measures on pretreatment postcontrast T1 MRIs of 117 GBM patients. Clinical variables were collected, tumours segmented, and measures computed including: contrast enhancing (CE), necrotic, and total volumes; maximal tumour diameter; equivalent spherical CE width and several geometric measures of the CE ''rim''. The significance of the measures was studied using proportional hazards analysis and Kaplan-Meier curves. Kaplan-Meier and univariate Cox survival analysis showed that total volume [p = 0.034, Hazard ratio (HR) = 1.574], CE volume (p = 0.017, HR = 1.659), spherical rim width (p = 0.007, HR = 1.749), and geometric heterogeneity (p = 0.015, HR = 1.646) were significant parameters in terms of overall survival (OS). Multivariable Cox analysis for OS provided the later two parameters as age-adjusted predictors of OS (p = 0.043, HR = 1.536 and p = 0.032, HR = 1.570, respectively). Patients with tumours having small geometric heterogeneity and/or spherical rim widths had significantly better prognosis. These novel imaging biomarkers have a strong individual and combined prognostic value for GBM patients. (orig.)

  13. On the importance of accounting for competing risks in pediatric cancer trials designed to delay or avoid radiotherapy: I. Basic concepts and first analyses.

    Science.gov (United States)

    Tai, Bee-Choo; Grundy, Richard G; Machin, David

    2010-04-01

    In trials designed to delay or avoid irradiation among children with malignant brain tumor, although irradiation after disease progression is an important event, patients who have disease progression may decline radiotherapy (RT), or those without disease progression may opt for elective RT. To accurately describe the cumulative need for RT in such instances, it is crucial to account for these distinct events and to evaluate how each contributes to the delay or advancement of irradiation via a competing risks analysis. We describe the summary of competing events in such trials using competing risks methods based on cumulative incidence functions and Gray's test. The results obtained are contrasted with standard survival methods based on Kaplan-Meier curves, cause-specific hazard functions and log-rank test. The Kaplan-Meier method overestimates all event-specific rates. The cause-specific hazard analysis showed reduction in hazards for all events (A: RT after progression; B: no RT after progression; C: elective RT) among children with ependymoma. For event A, a higher cumulative incidence was reported for ependymoma. Although Gray's test failed to detect any difference (p = 0.331) between histologic subtypes, the log-rank test suggested marginal evidence (p = 0.057). Similarly, for event C, the log-rank test found stronger evidence of reduction in hazard among those with ependymoma (p = 0.005) as compared with Gray's test (p = 0.086). To evaluate treatment differences, failing to account for competing risks using appropriate methodology may lead to incorrect interpretations.

  14. Multiphasic growth curve analysis.

    NARCIS (Netherlands)

    Koops, W.J.

    1986-01-01

    Application of a multiphasic growth curve is demonstrated with 4 data sets, adopted from literature. The growth curve used is a summation of n logistic growth functions. Human height growth curves of this type are known as "double logistic" (n = 2) and "triple logistic" (n = 3) growth curves (Bock

  15. Atypical Light Curves

    CERN Document Server

    Steenwyk, Steven D; Molnar, Lawrence A

    2013-01-01

    We have identified some two-hundred new variable stars in a systematic study of a data archive obtained with the Calvin-Rehoboth observatory. Of these, we present five close binaries showing behaviors presumably due to star spots or other magnetic activity. For context, we first present two new RS CVn systems whose behavior can be readily attribute to star spots. Then we present three new close binary systems that are rather atypical, with light curves that are changing over time in ways not easily understood in terms of star spot activity generally associated with magnetically active binary systems called RS CVn systems. Two of these three are contact binaries that exhibit gradual changes in average brightness without noticeable changes in light curve shape. A third system has shown such large changes in light curve morphology that we speculate this may be a rare instance of a system that transitions back and forth between contact and noncontact configurations, perhaps driven by magnetic cycles in at least o...

  16. String networks as tropical curves

    CERN Document Server

    Ray, Koushik

    2008-01-01

    A prescription for obtaining supergravity solutions for planar (p,q)-string networks is presented, based on earlier results. It shows that networks may be looked upon as tropical curves emerging as the spine of the amoeba of a holomorphic curve in M-theory. The Kaehler potential of supergravity is identified with the corresponding Ronkin function. Implications of this identification in counting dyons is discussed.

  17. Growth curves for Laron syndrome.

    OpenAIRE

    Laron, Z; Lilos, P; Klinger, B.

    1993-01-01

    Growth curves for children with Laron syndrome were constructed on the basis of repeated measurements made throughout infancy, childhood, and puberty in 24 (10 boys, 14 girls) of the 41 patients with this syndrome investigated in our clinic. Growth retardation was already noted at birth, the birth length ranging from 42 to 46 cm in the 12/20 available measurements. The postnatal growth curves deviated sharply from the normal from infancy on. Both sexes showed no clear pubertal spurt. Girls co...

  18. Linear Systems on Tropical Curves

    CERN Document Server

    Haase, Christian; Yu, Josephine

    2009-01-01

    A tropical curve \\Gamma is a metric graph with possibly unbounded edges, and tropical rational functions are continuous piecewise linear functions with integer slopes. We define the complete linear system |D| of a divisor D on a tropical curve \\Gamma analogously to the classical counterpart. We investigate the structure of |D| as a cell complex and show that linear systems are quotients of tropical modules, finitely generated by vertices of the cell complex. Using a finite set of generators, |D| defines a map from \\Gamma to a tropical projective space, and the image can be extended to a tropical curve of degree equal to \\deg(D). The tropical convex hull of the image realizes the linear system |D| as a polyhedral complex. We show that curves for which the canonical divisor is not very ample are hyperelliptic. We also show that the Picard group of a \\Q-tropical curve is a direct limit of critical groups of finite graphs converging to the curve.

  19. Spinal curves (image)

    Science.gov (United States)

    There are four natural curves in the spinal column. The cervical, thoracic, lumbar, and sacral curvature. The curves, along with the intervertebral disks, help to absorb and distribute stresses that occur from everyday activities such as walking or from ...

  20. Contractibility of curves

    Directory of Open Access Journals (Sweden)

    Janusz Charatonik

    1991-11-01

    Full Text Available Results concerning contractibility of curves (equivalently: of dendroids are collected and discussed in the paper. Interrelations tetween various conditions which are either sufficient or necessary for a curve to be contractible are studied.

  1. Parametrizing Algebraic Curves

    OpenAIRE

    Lemmermeyer, Franz

    2011-01-01

    We present the technique of parametrization of plane algebraic curves from a number theorist's point of view and present Kapferer's simple and beautiful (but little known) proof that nonsingular curves of degree > 2 cannot be parametrized by rational functions.

  2. Null Similar Curves with Variable Transformations in Minkowski 3-space

    OpenAIRE

    Önder, Mehmet

    2012-01-01

    In this study, we define a family of null curves in Minkowski 3-space and called null similar curves. We obtain some properties of these special curves. We show that two null curves are null similar curves if and only if these curves form a null Bertrand pair. Moreover, we obtain that the family of null geodesics and null helices form the families of null similar curves with variable transformation.

  3. ECM using Edwards curves

    DEFF Research Database (Denmark)

    Bernstein, Daniel J.; Birkner, Peter; Lange, Tanja;

    2013-01-01

    This paper introduces EECM-MPFQ, a fast implementation of the elliptic-curve method of factoring integers. EECM-MPFQ uses fewer modular multiplications than the well-known GMP-ECM software, takes less time than GMP-ECM, and finds more primes than GMP-ECM. The main improvements above the modular......-arithmetic level are as follows: (1) use Edwards curves instead of Montgomery curves; (2) use extended Edwards coordinates; (3) use signed-sliding-window addition-subtraction chains; (4) batch primes to increase the window size; (5) choose curves with small parameters and base points; (6) choose curves with large...

  4. Chest computed tomography scores are predictive of survival in patients with cystic fibrosis awaiting lung transplantation

    DEFF Research Database (Denmark)

    Loeve, Martine; Hop, Wim C. J.; de Bruijne, Marleen

    2012-01-01

    /inflammation" (INF), air trapping/hypoperfusion (AT), normal/hyperperfusion (NOR) and bulla/cysts (BUL). The volume of each component was computed using semi-automated software. Survival analysis included Kaplan-Meier curves, and Cox-regression models. Measurements and main results: 366 (186 males) out of 411...

  5. Age-dependent trends in postoperative mortality and preoperative comorbidity in isolated coronary artery bypass surgery

    DEFF Research Database (Denmark)

    Thorsteinsson, Kristinn; Fonager, Kirsten; Mérie, Charlotte;

    2016-01-01

    . Predictors of 30-day mortality were analysed in a multivariable Cox proportional-hazard models and survival at 1 and 5 years was estimated by Kaplan-Meier curves. RESULTS: A total of 38 830 patients were included; the median age was 65.4 ± 9.5 years, increasing over time to 66.6 ± 9.5 years. Males comprised...

  6. Reoperation for urinary incontinence

    DEFF Research Database (Denmark)

    Foss Hansen, Margrethe; Lose, Gunnar; Kesmodel, Ulrik Schiøler

    2016-01-01

    on a nationwide population. STUDY DESIGN: We used the Danish National Patient Registry to identify women who had surgery for urinary incontinence from 1998 through 2007 and the outcome was a reoperation within 5 years. Kaplan-Meier curves were used to estimate the rate of reoperation for 6 types of surgery...

  7. Registry of Hospital das Clínicas of the University of São Paulo Medical School: first official solid organ and tissue transplantation report - 2008

    Directory of Open Access Journals (Sweden)

    Estela Azeka

    2009-02-01

    Full Text Available OBJECTIVE: The aim of this study was to report a single center experience of organ and tissue transplantation INTRODUCTION: This is the first report of organ and tissue transplantation at the Hospital das Clínicas of the University of Sao Paulo Medical School. METHODS: We collected data from each type of organ transplantation from 2002 to 2007. The data collected were patient characteristics and actuarial survival Kaplan-Meier curves at 30 days, one year, and five years RESULTS: There were a total of 3,321 transplants at our institution and the 5-year survival curve ranged from 53% to 88%. CONCLUSION: This report shows that solid organ and tissue transplants are feasible within the institution and allow us to expect that the quality of transplantation will improve in the future.

  8. Usage of Calendula officinalis in the prevention and treatment of radiodermatitis: a randomized double-blind controlled clinical trial

    Directory of Open Access Journals (Sweden)

    Franciane Schneider

    2015-04-01

    Full Text Available OBJECTIVE To evaluate the efficacy of Calendula officinalis in relation to Essential Fatty Acids for the prevention and treatment of radiodermatitis. METHOD This is a randomized double-blind controlled clinical trial with 51 patients with head and neck cancer in radiotherapy treatment divided into two groups: control (27 and experimental (24. RESULTS There is statistically significant evidence (p-value = 0.0120 that the proportion of radiodermatitis grade 2 in Essential Fatty Acids group is higher than Calendula group. Through the Kaplan-Meier survival curve we observed that Essential Fatty Acids group has always remained below the Calendula group survival curve, due to the lower risk of developing radiodermatitis grade 1, which makes the usage of Calendula more effective, with statistical significance (p-value = 0.00402. CONCLUSION Calendula showed better therapeutic response than the Essential Fatty Acids in the prevention and treatment of radiodermatitis. Brazilian Registry of Clinical Trials: RBR-237v4b.

  9. Polymers in Curved Boxes

    CERN Document Server

    Yaman, K; Solis, F J; Witten, T A

    1996-01-01

    We apply results derived in other contexts for the spectrum of the Laplace operator in curved geometries to the study of an ideal polymer chain confined to a spherical annulus in arbitrary space dimension D and conclude that the free energy compared to its value for an uncurved box of the same thickness and volume, is lower when $D < 3$, stays the same when $D = 3$, and is higher when lowers the effective bending elasticity of the walls, and might induce spontaneous symmetry breaking, i.e. bending. (Actually, the above mentioned results show that {\\em {any}} shell in $D = 3$ induces this effect, except for a spherical shell). We compute the contribution of this effect to the bending rigidities in the Helfrich free energy expression.

  10. Topological recursion and mirror curves

    CERN Document Server

    Bouchard, Vincent

    2012-01-01

    We study the constant contributions to the free energies obtained through the topological recursion applied to the complex curves mirror to toric Calabi-Yau threefolds. We show that the recursion reproduces precisely the corresponding Gromov-Witten invariants, which can be encoded in powers of the MacMahon function. As a result, we extend the scope of the "remodeling conjecture" to the full free energies, including the constant contributions. In the process we study how the pair of pants decomposition of the mirror curves plays an important role in the topological recursion. We also show that the free energies are not, strictly speaking, symplectic invariants, and that the recursive construction of the free energies does not commute with certain limits of mirror curves.

  11. JUMPING THE CURVE

    Directory of Open Access Journals (Sweden)

    René Pellissier

    2012-01-01

    Full Text Available This paper explores the notion ofjump ing the curve,following from Handy 's S-curve onto a new curve with new rules policies and procedures. . It claims that the curve does not generally lie in wait but has to be invented by leadership. The focus of this paper is the identification (mathematically and inferentially ofthat point in time, known as the cusp in catastrophe theory, when it is time to change - pro-actively, pre-actively or reactively. These three scenarios are addressed separately and discussed in terms ofthe relevance ofeach.

  12. Peritonitis-free survival in peritoneal dialysis: an update taking competing risks into account.

    Science.gov (United States)

    Evans, David W; Ryckelynck, Jean-Philippe; Fabre, Emmanuel; Verger, Christian

    2010-07-01

    Peritonitis-free survival is commonly reported in the peritoneal dialysis (PD) literature. The Kaplan-Meier method appears to be the only technique used to date, although it has known limitations for cohorts with multiple outcomes, as in PD. In the presence of these 'competing risks' outcomes, the Kaplan-Meier estimate is interpretable only under restrictive assumptions. In contrast, methods which take competing risks into account provide unbiased estimates of probabilities of outcomes as actually experienced by patients. We analysed peritonitis-free survival in a cohort of 8711 incident patients from the 'Registre de Dialyse Péritonéale de Langue Française' between 1 January 2000 and 31 December 2007 by calculating the cumulative incidence (CI) of the first episode of peritonitis using the Kaplan-Meier method and a method accounting for competing risks. We compared the CI in different patient groups by the log-rank test and a test developed for competing risk data, Gray's test. After 5 years of PD, the CI of at least one peritonitis episode was 0.4, and the probability of any outcome was 0.96. The Kaplan-Meier method overestimated the CI by a large amount. Compared with the log-rank test, Gray's test led to different conclusions in three out of seven comparisons. The competing risk approach shows that the CI of at least one peritonitis episode was lower than reported by the Kaplan-Meier method but that survival peritonitis-free and still on PD was overall low. The competing risk approach provides estimates which have a clearer interpretation than Kaplan-Meier methods and could be more widely used in PD research.

  13. Space curves, anholonomy and nonlinearity

    Indian Academy of Sciences (India)

    Radha Balakrishnan

    2005-04-01

    Using classical differential geometry, we discuss the phenomenon of anholonomy that gets associated with a static and a moving curve. We obtain the expressions for the respective geometric phases in the two cases and interpret them. We show that there is a close connection between anholonomy and nonlinearity in a wide class of nonlinear systems.

  14. Simulating Supernova Light Curves

    Energy Technology Data Exchange (ETDEWEB)

    Even, Wesley Paul [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Dolence, Joshua C. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-05-05

    This report discusses supernova light simulations. A brief review of supernovae, basics of supernova light curves, simulation tools used at LANL, and supernova results are included. Further, it happens that many of the same methods used to generate simulated supernova light curves can also be used to model the emission from fireballs generated by explosions in the earth’s atmosphere.

  15. Tempo curves considered harmful

    NARCIS (Netherlands)

    Desain, P.; Honing, H.

    1993-01-01

    In the literature of musicology, computer music research and the psychology of music, timing or tempo measurements are mostly presented in the form of continuous curves. The notion of these tempo curves is dangerous, despite its widespread use, because it lulls its users into the false impression th

  16. Pairings on hyperelliptic curves

    CERN Document Server

    Balakrishnan, Jennifer; Chisholm, Sarah; Eisentraeger, Kirsten; Stange, Katherine; Teske, Edlyn

    2009-01-01

    We assemble and reorganize the recent work in the area of hyperelliptic pairings: We survey the research on constructing hyperelliptic curves suitable for pairing-based cryptography. We also showcase the hyperelliptic pairings proposed to date, and develop a unifying framework. We discuss the techniques used to optimize the pairing computation on hyperelliptic curves, and present many directions for further research.

  17. Retrospectives: Engel Curves

    National Research Council Canada - National Science Library

    Andreas Chai; Alessio Moneta

    2010-01-01

    ..., Professor of Economics, University of Illinois, Chicago, at jpersky@uic.edu jpersky@uic.edu.. Introduction Introduction Engel curves describe how household expenditure on particular goods or Engel curves describe how household expenditure on particular goods or services depends on household income. The name comes from the German st...

  18. Shock detachment from curved wedges

    Science.gov (United States)

    Mölder, S.

    2017-03-01

    Curved shock theory is used to show that the flow behind attached shocks on doubly curved wedges can have either positive or negative post-shock pressure gradients depending on the freestream Mach number, the wedge angle and the two wedge curvatures. Given enough wedge length, the flow near the leading edge can choke to force the shock to detach from the wedge. This local choking can preempt both the maximum deflection and the sonic criteria for shock detachment. Analytical predictions for detachment by local choking are supported by CFD results.

  19. Shock detachment from curved wedges

    Science.gov (United States)

    Mölder, S.

    2017-09-01

    Curved shock theory is used to show that the flow behind attached shocks on doubly curved wedges can have either positive or negative post-shock pressure gradients depending on the freestream Mach number, the wedge angle and the two wedge curvatures. Given enough wedge length, the flow near the leading edge can choke to force the shock to detach from the wedge. This local choking can preempt both the maximum deflection and the sonic criteria for shock detachment. Analytical predictions for detachment by local choking are supported by CFD results.

  20. Curved branes with regular support

    Energy Technology Data Exchange (ETDEWEB)

    Antoniadis, Ignatios [Sorbonne Universites, LPTHE, UMR CNRS 7589, Paris (France); University of Bern, Albert Einstein Center for Fundamental Physics, ITP, Bern (Switzerland); Cotsakis, Spiros; Klaoudatou, Ifigeneia [American University of the Middle East, Department of Mathematics, P. O. Box 220, Dasman (Kuwait)

    2016-09-15

    We study spacetime singularities in a general five-dimensional braneworld with curved branes satisfying four-dimensional maximal symmetry. The bulk is supported by an analog of perfect fluid with the time replaced by the extra coordinate. We show that contrary to the existence of finite-distance singularities from the brane location in any solution with flat (Minkowski) branes, in the case of curved branes there are singularity-free solutions for a range of equations of state compatible with the null energy condition. (orig.)

  1. The curve shortening problem

    CERN Document Server

    Chou, Kai-Seng

    2001-01-01

    Although research in curve shortening flow has been very active for nearly 20 years, the results of those efforts have remained scattered throughout the literature. For the first time, The Curve Shortening Problem collects and illuminates those results in a comprehensive, rigorous, and self-contained account of the fundamental results.The authors present a complete treatment of the Gage-Hamilton theorem, a clear, detailed exposition of Grayson''s convexity theorem, a systematic discussion of invariant solutions, applications to the existence of simple closed geodesics on a surface, and a new, almost convexity theorem for the generalized curve shortening problem.Many questions regarding curve shortening remain outstanding. With its careful exposition and complete guide to the literature, The Curve Shortening Problem provides not only an outstanding starting point for graduate students and new investigations, but a superb reference that presents intriguing new results for those already active in the field.

  2. Laffer Curves and Home Production

    Directory of Open Access Journals (Sweden)

    Kotamäki Mauri

    2017-06-01

    Full Text Available In the earlier related literature, consumption tax rate Laffer curve is found to be strictly increasing (see Trabandt and Uhlig (2011. In this paper, a general equilibrium macro model is augmented by introducing a substitute for private consumption in the form of home production. The introduction of home production brings about an additional margin of adjustment – an increase in consumption tax rate not only decreases labor supply and reduces the consumption tax base but also allows a substitution of market goods with home-produced goods. The main objective of this paper is to show that, after the introduction of home production, the consumption tax Laffer curve exhibits an inverse U-shape. Also the income tax Laffer curves are significantly altered. The result shown in this paper casts doubt on some of the earlier results in the literature.

  3. Algebraic curves of maximal cyclicity

    Science.gov (United States)

    Caubergh, Magdalena; Dumortier, Freddy

    2006-01-01

    The paper deals with analytic families of planar vector fields, studying methods to detect the cyclicity of a non-isolated closed orbit, i.e. the maximum number of limit cycles that can locally bifurcate from it. It is known that this multi-parameter problem can be reduced to a single-parameter one, in the sense that there exist analytic curves in parameter space along which the maximal cyclicity can be attained. In that case one speaks about a maximal cyclicity curve (mcc) in case only the number is considered and of a maximal multiplicity curve (mmc) in case the multiplicity is also taken into account. In view of obtaining efficient algorithms for detecting the cyclicity, we investigate whether such mcc or mmc can be algebraic or even linear depending on certain general properties of the families or of their associated Bautin ideal. In any case by well chosen examples we show that prudence is appropriate.

  4. Kernelized partial least squares for feature reduction and classification of gene microarray data

    Directory of Open Access Journals (Sweden)

    Land Walker H

    2011-12-01

    Full Text Available Abstract Background The primary objectives of this paper are: 1. to apply Statistical Learning Theory (SLT, specifically Partial Least Squares (PLS and Kernelized PLS (K-PLS, to the universal "feature-rich/case-poor" (also known as "large p small n", or "high-dimension, low-sample size" microarray problem by eliminating those features (or probes that do not contribute to the "best" chromosome bio-markers for lung cancer, and 2. quantitatively measure and verify (by an independent means the efficacy of this PLS process. A secondary objective is to integrate these significant improvements in diagnostic and prognostic biomedical applications into the clinical research arena. That is, to devise a framework for converting SLT results into direct, useful clinical information for patient care or pharmaceutical research. We, therefore, propose and preliminarily evaluate, a process whereby PLS, K-PLS, and Support Vector Machines (SVM may be integrated with the accepted and well understood traditional biostatistical "gold standard", Cox Proportional Hazard model and Kaplan-Meier survival analysis methods. Specifically, this new combination will be illustrated with both PLS and Kaplan-Meier followed by PLS and Cox Hazard Ratios (CHR and can be easily extended for both the K-PLS and SVM paradigms. Finally, these previously described processes are contained in the Fine Feature Selection (FFS component of our overall feature reduction/evaluation process, which consists of the following components: 1. coarse feature reduction, 2. fine feature selection and 3. classification (as described in this paper and prediction. Results Our results for PLS and K-PLS showed that these techniques, as part of our overall feature reduction process, performed well on noisy microarray data. The best performance was a good 0.794 Area Under a Receiver Operating Characteristic (ROC Curve (AUC for classification of recurrence prior to or after 36 months and a strong 0.869 AUC for

  5. Learning Curve? Which One?

    Directory of Open Access Journals (Sweden)

    Paulo Prochno

    2004-07-01

    Full Text Available Learning curves have been studied for a long time. These studies provided strong support to the hypothesis that, as organizations produce more of a product, unit costs of production decrease at a decreasing rate (see Argote, 1999 for a comprehensive review of learning curve studies. But the organizational mechanisms that lead to these results are still underexplored. We know some drivers of learning curves (ADLER; CLARK, 1991; LAPRE et al., 2000, but we still lack a more detailed view of the organizational processes behind those curves. Through an ethnographic study, I bring a comprehensive account of the first year of operations of a new automotive plant, describing what was taking place on in the assembly area during the most relevant shifts of the learning curve. The emphasis is then on how learning occurs in that setting. My analysis suggests that the overall learning curve is in fact the result of an integration process that puts together several individual ongoing learning curves in different areas throughout the organization. In the end, I propose a model to understand the evolution of these learning processes and their supporting organizational mechanisms.

  6. Double-blind comparison of survival analysis models using a bespoke web system.

    Science.gov (United States)

    Taktak, A F G; Setzkorn, C; Damato, B E

    2006-01-01

    The aim of this study was to carry out a comparison of different linear and non-linear models from different centres on a common dataset in a double-blind manner to eliminate bias. The dataset was shared over the Internet using a secure bespoke environment called geoconda. Models evaluated included: (1) Cox model, (2) Log Normal model, (3) Partial Logistic Spline, (4) Partial Logistic Artificial Neural Network and (5) Radial Basis Function Networks. Graphical analysis of the various models with the Kaplan-Meier values were carried out in 3 survival groups in the test set classified according to the TNM staging system. The discrimination value for each model was determined using the area under the ROC curve. Results showed that the Cox model tended towards optimism whereas the partial logistic Neural Networks showed slight pessimism.

  7. The Impact of the Combination of Circular Curve and Transition Curve on Highway Operation Security

    Directory of Open Access Journals (Sweden)

    Cao Youlu

    2015-07-01

    Full Text Available By investigating the accident in 2009 and 2011 of Taijiu Expressway, the study analyzed the relationship between the horizontal curve radiuses, the length of horizontal curve, the length of transition curve and the number of accidents, established the corresponding regression model. The trend of accidents was determined with different length of transition curve and different combination of circular curve according to this model. The results show that the circular curve radius and length of transition curve increase with the decreases of accidents number, the number of accidents decreases with the increase of the ratio of the length of the transition curve and the length of the round curve. When the ratio of the parameters of the transition curve and the radius of the circle is between 0.3-0.6, the accidents are more focused. The bigger change rate of curves is, there are more accidents of flat curve. To evaluate road traffic safety from the perspective of horizontal curve alignment design, these regularities have very important reference.

  8. SRHA calibration curve

    Data.gov (United States)

    U.S. Environmental Protection Agency — an UV calibration curve for SRHA quantitation. This dataset is associated with the following publication: Chang, X., and D. Bouchard. Surfactant-Wrapped Multiwalled...

  9. ROBUST DECLINE CURVE ANALYSIS

    Directory of Open Access Journals (Sweden)

    Sutawanir Darwis

    2012-05-01

    Full Text Available Empirical decline curve analysis of oil production data gives reasonable answer in hyperbolic type curves situations; however the methodology has limitations in fitting real historical production data in present of unusual observations due to the effect of the treatment to the well in order to increase production capacity. The development ofrobust least squares offers new possibilities in better fitting production data using declinecurve analysis by down weighting the unusual observations. This paper proposes a robustleast squares fitting lmRobMM approach to estimate the decline rate of daily production data and compares the results with reservoir simulation results. For case study, we usethe oil production data at TBA Field West Java. The results demonstrated that theapproach is suitable for decline curve fitting and offers a new insight in decline curve analysis in the present of unusual observations.

  10. Arithmetic of Shimura curves

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    This is the note for a series of lectures that the author gave at the Centre de Recerca Matemtica (CRM), Bellaterra, Barcelona, Spain on October 19–24, 2009. The aim is to give a comprehensive description of some recent work of the author and his students on generalisations of the Gross-Zagier formula, Euler systems on Shimura curves, and rational points on elliptic curves.

  11. TGF-beta receptor 2 downregulation in tumour-associated stroma worsens prognosis and high-grade tumours show more tumour-associated macrophages and lower TGF-beta1 expression in colon carcinoma: a retrospective study

    Directory of Open Access Journals (Sweden)

    Papadopoulos Thomas

    2007-08-01

    Full Text Available Abstract Background Histological phenotype and clinical behaviour of malignant tumours are not only dependent on alterations in the epithelial cell compartment, but are affected by their interaction with inflammatory cells and tumour-associated stroma. Studies in animal models have shown influence of tumour-associated macrophages (TAM on histological grade of differentiation in colon carcinoma. Disruption of transforming growth factor beta (TGF-beta signalling in tumour cells is related to more aggressive clinical behaviour. Expression data of components of this pathway in tumour-associated stroma is limited. Methods Tissue micro arrays of 310 colon carcinomas from curatively resected patients in UICC stage II and III were established. In a first step we quantified amount of CD68 positive TAMs and expression of components of TGF-beta signalling (TGF-beta1, TGF-beta receptors type 1 and 2, Smad 3 and 4 in tumour and associated stroma. Further we analyzed correlation to histological and clinical parameters (histological grade of differentiation (low-grade (i.e. grade 1 and 2 vs. high-grade (i.e. grade 3 and 4, lymph node metastasis, distant metastasis, 5 year cancer related survival using Chi-square or Fisher's exact test, when appropriate, to compare frequencies, Kaplan-Meier method to calculate 5-year rates of distant metastases and cancer-related survival and log rank test to compare the rates of distant metastases and survival. To identify independent prognostic factors Cox regression analysis including lymph node status and grading was performed. Results High-grade tumours and those with lymph node metastases showed higher rates of TAMs and lower expression of TGF-beta1. Loss of nuclear Smad4 expression in tumor was associated with presence of lymph node metastasis, but no influence on prognosis could be demonstrated. Decrease of both TGF-beta receptors in tumour-associated stroma was associated with increased lymph node metastasis and

  12. Erythropoietin and erythropoietin receptor in hepatocellular carcinoma: correlation with vasculogenic mimicry and poor prognosis.

    Science.gov (United States)

    Yang, Zhihong; Sun, Baocun; Zhao, Xiulan; Shao, Bing; An, Jindan; Gu, Qiang; Wang, Yong; Dong, Xueyi; Zhang, Yanhui; Qiu, Zhiqiang

    2015-01-01

    To evaluate erythropoietin (Epo) and erythropoietin receptor (EpoR) expression, its relationship with vasculogenic mimicry (VM) and its prognostic value in human hepatocellular carcinoma (HCC), we examined Epo/EpoR expression and VM formation using immunohistochemistry and CD31/PAS (periodic acid-Schiff) double staining on 92 HCC specimens. The correlation between Epo/EpoR expression and VM formation was analyzed using two-tailed Chi-square test and Spearman correlation analysis. Survival curves were generated using Kaplan-Meier method. Multivariate analysis was performed using Cox regression model to assess the prognostic values. Results showed positive correlation between Epo/EpoR expression and VM formation (P age, Epo and EpoR were independent prognostic factors related to OS. These results will provide evidence for further research on HCC microcirculation patterns and also will provide new possible targets for HCC diagnosis and treatment.

  13. Clinical correlation between myeloperoxidase and acute coronary syndrome

    Institute of Scientific and Technical Information of China (English)

    Jie Wang; Yanwei Xing; Changsheng Ma; Shihong Li; Zhizhong Li; Yonghong Gao; Yibing Nong

    2007-01-01

    Objective To study whether myeloperoxidase (MPO) can provide prognostic information in patients with acute coronary syndromes (ACS). Methods The study population consisted of 274 consecutive patients with ACS. All patients underwent coronary angiography which showed significant coronary artery disease and blood samples were collected at admission. Follow-ups were scheduled at 1, 3, and 6 months.The end point included cardiac death, acute myocardial infarction (MI), percutaneous or surgical revascularization. Results Patients with elevated MPO serum levels (MPO ≥ 72.2 AUU/L) were more likely to have diabetics and had a history of coronary events. Kaplan-Meier event rate curves with accumulative incidence of end point at 6-month follow-up in the MPO ≥ 72.2 AUU/L group was significantly higher than in MPO<72.2 AUU/L group. Conclusions MPO may be a powerful predictor of adverse outcome in patients with ACS.

  14. Design and analysis of clinical trials in the presence of delayed treatment effect.

    Science.gov (United States)

    Sit, Tony; Liu, Mengling; Shnaidman, Michael; Ying, Zhiliang

    2016-05-20

    In clinical trials with survival endpoint, it is common to observe an overlap between two Kaplan-Meier curves of treatment and control groups during the early stage of the trials, indicating a potential delayed treatment effect. Formulas have been derived for the asymptotic power of the log-rank test in the presence of delayed treatment effect and its accompanying sample size calculation. In this paper, we first reformulate the alternative hypothesis with the delayed treatment effect in a rescaled time domain, which can yield a simplified sample size formula for the log-rank test in this context. We further propose an intersection-union test to examine the efficacy of treatment with delayed effect and show it to be more powerful than the log-rank test. Simulation studies are conducted to demonstrate the proposed methods. Copyright © 2016 John Wiley & Sons, Ltd.

  15. Overactive bladder is a negative predictor of achieving continence after robot-assisted radical prostatectomy.

    Science.gov (United States)

    Yamada, Yuta; Fujimura, Tetsuya; Fukuhara, Hiroshi; Sugihara, Toru; Miyazaki, Hideyo; Nakagawa, Tohru; Kume, Haruki; Igawa, Yasuhiko; Homma, Yukio

    2017-10-01

    To investigate predictors of continence outcomes after robot-assisted radical prostatectomy. Clinical records of 272 patients who underwent robot-assisted radical prostatectomy were investigated. Preoperative Overactive Bladder Symptom Score, International Prostate Symptom Score and clinicopathological factors were investigated, and relationships between factors and recovery of continence after robot-assisted radical prostatectomy were assessed. The presence of overactive bladder was defined as having urgency for more than once a week and having ≥3 points according to the Overactive Bladder Symptom Score. Age (≤66 years) was significantly associated with continence within 6 months after robot-assisted radical prostatectomy (P = 0.033). The absence of overactive bladder and lower Overactive Bladder Symptom Score (robot-assisted radical prostatectomy, Kaplan-Meier curves showed earlier recovery in "age ≤66 years," "prostate weight ≤40 g" and "overactive bladder symptom score robot-assisted radical prostatectomy. © 2017 The Japanese Urological Association.

  16. Uniform trigonometric polynomial B-spline curves

    Institute of Scientific and Technical Information of China (English)

    吕勇刚; 汪国昭; 杨勋年

    2002-01-01

    This paper presents a new kind of uniform spline curve, named trigonometric polynomialB-splines, over space Ω = span{sint, cost, tk-3,tk-4,…,t,1} of which k is an arbitrary integerlarger than or equal to 3. We show that trigonometric polynomial B-spline curves have many similarV properties to traditional B-splines. Based on the explicit representation of the curve we have also presented the subdivision formulae for this new kind of curve. Since the new spline can include both polynomial curves and trigonometric curves as special cases without rational form, it can be used as an efficient new model for geometric design in the fields of CAD/CAM.

  17. Principal Curves on Riemannian Manifolds.

    Science.gov (United States)

    Hauberg, Soren

    2016-09-01

    Euclidean statistics are often generalized to Riemannian manifolds by replacing straight-line interpolations with geodesic ones. While these Riemannian models are familiar-looking, they are restricted by the inflexibility of geodesics, and they rely on constructions which are optimal only in Euclidean domains. We consider extensions of Principal Component Analysis (PCA) to Riemannian manifolds. Classic Riemannian approaches seek a geodesic curve passing through the mean that optimizes a criteria of interest. The requirements that the solution both is geodesic and must pass through the mean tend to imply that the methods only work well when the manifold is mostly flat within the support of the generating distribution. We argue that instead of generalizing linear Euclidean models, it is more fruitful to generalize non-linear Euclidean models. Specifically, we extend the classic Principal Curves from Hastie & Stuetzle to data residing on a complete Riemannian manifold. We show that for elliptical distributions in the tangent of spaces of constant curvature, the standard principal geodesic is a principal curve. The proposed model is simple to compute and avoids many of the pitfalls of traditional geodesic approaches. We empirically demonstrate the effectiveness of the Riemannian principal curves on several manifolds and datasets.

  18. The soil reference shrinkage curve

    CERN Document Server

    Chertkov, V Y

    2014-01-01

    A recently proposed model showed how a clay shrinkage curve is transformed to the soil shrinkage curve at the soil clay content higher than a critical one. The objective of the present work was to generalize this model to the soil clay content lower a critical one. I investigated (i) the reference shrinkage curve, that is, one without cracks; (ii) the superficial layer of aggregates, with changed pore structure compared with the intraaggregate matrix; and (iii) soils with sufficiently low clay content where there are large pores inside the intraaggregate clay (so-called lacunar pores). The methodology is based on detail accounting for different contributions to the soil volume and water content during shrinkage. The key point is the calculation of the lacunar pore volume variance at shrinkage. The reference shrinkage curve is determined by eight physical soil parameters: (1) oven-dried specific volume; (2) maximum swelling water content; (3) mean solid density; (4) soil clay content; (5) oven-dried structural...

  19. Measuring Model Rocket Engine Thrust Curves

    Science.gov (United States)

    Penn, Kim; Slaton, William V.

    2010-01-01

    This paper describes a method and setup to quickly and easily measure a model rocket engine's thrust curve using a computer data logger and force probe. Horst describes using Vernier's LabPro and force probe to measure the rocket engine's thrust curve; however, the method of attaching the rocket to the force probe is not discussed. We show how a…

  20. Measuring Model Rocket Engine Thrust Curves

    Science.gov (United States)

    Penn, Kim; Slaton, William V.

    2010-01-01

    This paper describes a method and setup to quickly and easily measure a model rocket engine's thrust curve using a computer data logger and force probe. Horst describes using Vernier's LabPro and force probe to measure the rocket engine's thrust curve; however, the method of attaching the rocket to the force probe is not discussed. We show how a…

  1. Approximation by planar elastic curves

    DEFF Research Database (Denmark)

    Brander, David; Gravesen, Jens; Nørbjerg, Toke Bjerge

    2016-01-01

    We give an algorithm for approximating a given plane curve segment by a planar elastic curve. The method depends on an analytic representation of the space of elastic curve segments, together with a geometric method for obtaining a good initial guess for the approximating curve. A gradient......-driven optimization is then used to find the approximating elastic curve....

  2. In Vitro Fatigue Resistance of Teeth Restored With Bulk Fill versus Conventional Composite Resin.

    Science.gov (United States)

    Rauber, Gabrielle Branco; Bernardon, Jussara Karina; Vieira, Luiz Clovis Cardoso; Maia, Hamilton Pires; Horn, Françoá; Roesler, Carlos Rodrigo de Mello

    2016-01-01

    The aim of this study was to compare the fatigue resistance of restored teeth with bulk fill composite resin, conventional composite resin with incremental insertion and unprepared sound teeth. Twenty-eight extracted maxillary premolars were selected and divided into 4 groups based on composite resin and insertion technique: control (C), conventional composite resin with incremental insertion (I) and bulk fill composite resin with three (BF3) or single increment (BF1). The restored specimens were submitted to fatigue resistance test with a 5 Hz frequency. An initial application of 5,000 sinusoidal load cycles with a minimum force of 50 N and a maximum force of 200 N was used. Next, were applied stages of 30,000 load cycles with the maximum force increasing gradually: 400, 600, 800, 1000, 1200 and 1400 N. The test was concluded when 185,000 load cycles were achieved or the specimen failed. The fatigue resistance data were recorded for comparison, using the Kaplan-Meier survival curve and analyzed by log-rank test at 0.05 significance. Fractures were classified based on the position of the failure - above or below the cementoenamel junction (CEJ). Statistical analysis of the Kaplan-Meier survival curve and log-rank test showed a significant difference between groups (p=0.001). The fracture analysis demonstrated that only 28.58% of failures were below the CEJ in group C, while for groups I, BF1 and BF3 they were 42.85%, 85.71% and 85.71%, respectively. Teeth restored with composite bulk fill in both techniques present similar fatigue resistance values compared with those restored with a conventional incremental insertion of composite, while the fatigue strength values of unprepared sound teeth were higher. Furthermore, unprepared sound teeth showed a lower percentage of fractures below the CEJ.

  3. Pulmonary function tests in patients with amyotrophic lateral sclerosis and the association between these tests and survival.

    Directory of Open Access Journals (Sweden)

    Seyed-Ali Javad Mousavi

    2014-09-01

    Full Text Available The rapidity of progression of amyotrophic lateral sclerosis (ALS to death or respiratory failure impacts patients, clinicians, and clinical investigators. The aim of this study is to evaluate of the pulmonary function tests (PFTs in patients with ALS and the association between these PFTs and survival Methods: A total of 36 ALS patients who PFTs, including vital capacity (VC, maximum mid-expiratory flow rate (MMEFR, forced vital capacity (FVC, and forced expiratory volume in 1 s (FEV1, were available from the time of diagnosis were included in this study. Non-pulmonary characteristics assessed at the time of PFTs. Data were analyzed using chi-square, Student's independent t-test, Kaplan-Meier, correlation, and receiver operating characteristic (ROC curve.The mean age of subjects was 55.36 (SD = 12.24 year, and the male to female ratio was 2.6. Twenty-five (69.4% were died in 5 years period of our study. The mean and median survival time (In months was calculated as 42.51 (95% confidence interval [CI] 33.64-51.39 and 38 (95% CI 27.23-48.77 months, respectively. The rate of ALS survival was 74% at 1(st year, 41% at 3(rd year and 10% at 5(th year of starting symptoms. The results of Kaplan-Meier test showed survival was significantly longer in the group with PFTs closer to normal. In addition, ROC analysis showed that FVC < 50% could potentially be a predictor of death in ALS patients(P = 0.003, area under curve = 0.649.We found single measures of upright FVC, FEV1 to be significantly associated with survival, even after controlling for relevant non-pulmonary patient characteristics. Our study demonstrated that upright FVC, FEV1, VC, and MMEFR are useful non-invasive measures in the prediction of survival in ALS.

  4. Power Curve Measurements REWS

    DEFF Research Database (Denmark)

    Gómez Arranz, Paula; Vesth, Allan

    This report describes the power curve measurements carried out on a given wind turbine in a chosen period. The measurements were carried out following the measurement procedure in the draft of IEC 61400-12-1 Ed.2 [1], with some deviations mostly regarding uncertainty calculation. Here, the refere......This report describes the power curve measurements carried out on a given wind turbine in a chosen period. The measurements were carried out following the measurement procedure in the draft of IEC 61400-12-1 Ed.2 [1], with some deviations mostly regarding uncertainty calculation. Here......, the reference wind speed used in the power curve is the equivalent wind speed obtained from lidar measurements at several heights between lower and upper blade tip, in combination with a hub height meteorological mast. The measurements have been performed using DTU’s measurement equipment, the analysis...

  5. The sales learning curve.

    Science.gov (United States)

    Leslie, Mark; Holloway, Charles A

    2006-01-01

    When a company launches a new product into a new market, the temptation is to immediately ramp up sales force capacity to gain customers as quickly as possible. But hiring a full sales force too early just causes the firm to burn through cash and fail to meet revenue expectations. Before it can sell an innovative product efficiently, the entire organization needs to learn how customers will acquire and use it, a process the authors call the sales learning curve. The concept of a learning curve is well understood in manufacturing. Employees transfer knowledge and experience back and forth between the production line and purchasing, manufacturing, engineering, planning, and operations. The sales learning curve unfolds similarly through the give-and-take between the company--marketing, sales, product support, and product development--and its customers. As customers adopt the product, the firm modifies both the offering and the processes associated with making and selling it. Progress along the manufacturing curve is measured by tracking cost per unit: The more a firm learns about the manufacturing process, the more efficient it becomes, and the lower the unit cost goes. Progress along the sales learning curve is measured in an analogous way: The more a company learns about the sales process, the more efficient it becomes at selling, and the higher the sales yield. As the sales yield increases, the sales learning process unfolds in three distinct phases--initiation, transition, and execution. Each phase requires a different size--and kind--of sales force and represents a different stage in a company's production, marketing, and sales strategies. Adjusting those strategies as the firm progresses along the sales learning curve allows managers to plan resource allocation more accurately, set appropriate expectations, avoid disastrous cash shortfalls, and reduce both the time and money required to turn a profit.

  6. Algebraic curves and cryptography

    CERN Document Server

    Murty, V Kumar

    2010-01-01

    It is by now a well-known paradigm that public-key cryptosystems can be built using finite Abelian groups and that algebraic geometry provides a supply of such groups through Abelian varieties over finite fields. Of special interest are the Abelian varieties that are Jacobians of algebraic curves. All of the articles in this volume are centered on the theme of point counting and explicit arithmetic on the Jacobians of curves over finite fields. The topics covered include Schoof's \\ell-adic point counting algorithm, the p-adic algorithms of Kedlaya and Denef-Vercauteren, explicit arithmetic on

  7. Power Curve Measurements REWS

    DEFF Research Database (Denmark)

    Gómez Arranz, Paula; Villanueva, Héctor

    This report describes the power curve measurements carried out on a given wind turbine in a chosen period. The measurements were carried out following the measurement procedure in the draft of IEC 61400-12-1 Ed.2 [1], with some deviations mostly regarding uncertainty calculation. Here......, the reference wind speed used in the power curve is the equivalent wind speed obtained from lidar measurements at several heights between lower and upper blade tip, in combination with a hub height meteorological mast. The measurements have been performed using DTU’s measurement equipment, the analysis...

  8. Power curve investigation

    DEFF Research Database (Denmark)

    Villanueva, Héctor; Vesth, Allan

    are not performed according to IEC 61400-12-1 [1]. Therefore, the results presented in this report cannot be considered a power curve according to the reference standard, and are referred to as “power curve investigation” instead. The measurements have been performed by a customer and the data analysis has been......This report describes the analysis carried out with data from a given turbine in a wind farm and a chosen period. The purpose of the analysis is to correlate the power output of the wind turbine to the wind speed measured by a nacelle-mounted anemometer. The measurements and analysis...

  9. The early predictive value of a decrease of metabolic tumor volume in repeated (18)F-FDG PET/CT for recurrence of locally advanced non-small cell lung cancer with concurrent radiochemotherapy.

    Science.gov (United States)

    Huang, Wei; Liu, Bo; Fan, Min; Zhou, Tao; Fu, Zheng; Zhang, Zicheng; Li, Hongsheng; Li, Baosheng

    2015-03-01

    The aim of this study is to investigate the value of [(18)F] fluorodeoxyglucose positron emission tomography/computed tomography ((18)F FDG PET/CT) to predict recurrence of patients with locally advanced non-small cell lung cancer (NSCLC) during the early stage of concurrent chemoradiotherapy (CCRT). A total of 53 stage III NSCLC patients without diabetics or undergoing surgery were enrolled in the prospective study. Those patients were evaluated by FDG PET before and following 40Gy radiotherapy (RT) with a concurrent cisplatin-based heterogeneous chemotherapy regimen. Semiquantitative assessment was used to determine maximum and mean SUVs (SUVmax/SUVmean) and metabolic tumor volume (MTV) of the primary tumor. The prognostic significance of PET/CT parameters and other clinical variables was assessed using Cox regression analyses. The cutoffs of PET/CT parameters which have been determined by the previous study were used to separate the groups with Kaplan-Meier curves. Recurrence rates at 1- and 2-years were 18.9% (10/53) and 50.9% (27/53) for all patients, respectively. Cox regression analysis showed that the only prognostic factor for recurrence was a decrease of MTV. Using the cutoff of 29.7%, a decrease of MTV can separate the patients into 2 groups with Kaplan-Meier curve successfully. The prospective study has reinforced the early predictive value of MTV in repeated (18)F-FDG PET/CT for recurrence in a subgroup of locally advanced NSCLC who underwent CCRT. A decrease of MTV in (18)F-FDG uptake by the primary tumor correlates with higher LRFS. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  10. Left ventricular dyssynchrony assessed by gated SPECT phase analysis is an independent predictor of death in patients with advanced coronary artery disease and reduced left ventricular function not undergoing cardiac resynchronization therapy

    Energy Technology Data Exchange (ETDEWEB)

    Uebleis, Christopher; Hellweger, Stefan; Lehner, Sebastian; Haug, Alexander; Bartenstein, Peter; Cumming, Paul; Hacker, Marcus [Ludwig-Maximilians University, Department of Nuclear Medicine, Munich (Germany); Laubender, Ruediger Paul [Ludwig-Maximilians University, Institute of Medical Informatics, Biometry, and Epidemiology (IBE), Munich (Germany); Becker, Alexander [Ludwig-Maximilians University, Medical Department I, Munich (Germany); Sohn, Hae-Young [Ludwig-Maximilians University, Medical Department Innenstadt, Munich (Germany); Van Kriekinge, Serge D.; Slomka, Piotr J. [Cedars-Sinai Medical Center, Los Angeles, CA (United States); UCLA, David Geffen School of Medicine, Los Angeles, CA (United States)

    2012-10-15

    Left ventricular (LV) mechanical dyssynchrony (LVMD) was assessed by gated single-photon emission CT myocardial perfusion imaging (MPI) as an independent predictor of death from any cause in patients with known coronary artery disease (CAD) and reduced LV function. Between 2001 and 2010, 135 patients (64 {+-} 11 years of age, 84 % men) with known CAD, reduced LV ejection fraction (LVEF, 38 {+-} 15 %) and without an implanted cardiac resynchronization therapy device underwent gated MPI at rest. LV functional evaluation, which included phase analysis, was conducted to identify patients with LVMD. Kaplan-Meier survival curves were calculated for death of any cause during a mean follow-up of 2.0 {+-} 1.7 years. Uni- and multivariate Cox proportional hazards regression models were calculated to identify independent predictors of death from any cause. Of the 135 patients, 30 (22 %) died during follow-up (18 cardiac deaths and 12 deaths from other causes). Kaplan-Meier curves showed a significantly shorter survival time in the patients with severely reduced LVEF (<30 %, n = 45) or with LVMD (n = 81, log-rank test P <0.005). Cox models identified LVMD, LVEF <30 % and a total perfusion deficit at rest of {>=}20 % as independent predictors of death from any cause. While patients with LVEF <30 % in conjunction with LVMD had similar survival times irrespective of whether they had early revascularization or medical therapy, those patients with LVEF {>=}30% and LVMD who underwent revascularization had significantly longer survival. In patients with known CAD and reduced LV function, dyssynchrony of the LV is an independent predictor of death from any cause. (orig.)

  11. An Approximation Method of NURBS Curves in NC Machining

    Institute of Scientific and Technical Information of China (English)

    YUE Ying; HAN Qingyao; WANG Zhangqi

    2006-01-01

    An algorithm for approximating arbitrary NURBS curve with straight line is presented. Firstly, NURBS curve is acquired according to data points on the curve. Secondly, Approximating arbitrary NURBS curve is based on dichotomy. The resulting straight line approaches to the original curve with relatively fewer segments within the required tolerance. The example shows that the algorithm is simple and its approximation precision is high. The method is most useful in numerical control to drive the cutter along straight line or circular paths.

  12. Paths of algebraic hyperbolic curves

    Institute of Scientific and Technical Information of China (English)

    Ya-juan LI; Li-zheng LU; Guo-zhao WANG

    2008-01-01

    Cubic algebraic hyperbolic (AH) Bezier curves and AH spline curves are defined with a positive parameter α in the space spanned by {1, t, sinht, cosht}. Modifying the value of α yields a family of AH Bezier or spline curves with the family parameter α. For a fixed point on the original curve, it will move on a defined curve called "path of AH curve" (AH Bezier and AH spline curves) when α changes. We describe the geometric effects of the paths and give a method to specify a curve passing through a given point.

  13. Nacelle lidar power curve

    DEFF Research Database (Denmark)

    Gómez Arranz, Paula; Wagner, Rozenn

    This report describes the power curve measurements performed with a nacelle LIDAR on a given wind turbine in a wind farm and during a chosen measurement period. The measurements and analysis are carried out in accordance to the guidelines in the procedure “DTU Wind Energy-E-0019” [1]. The reporting...

  14. Graphs, Curves and Dynamics

    NARCIS (Netherlands)

    Kool, J.

    2013-01-01

    This thesis has three main subjects. The first subject is Measure-theoretic rigidity of Mumford Curves. One can describe isomorphism of two compact hyperbolic Riemann surfaces of the same genus by a measure-theoretic property: a chosen isomorphism of their fundamental groups corresponds to a homeomo

  15. Power Curve Measurements

    DEFF Research Database (Denmark)

    Vesth, Allan; Kock, Carsten Weber

    The report describes power curve measurements carried out on a given wind turbine. The measurements are carried out in accordance to Ref. [1]. A site calibration has been carried out; see Ref. [2], and the measured flow correction factors for different wind directions are used in the present anal...

  16. Power Curve Measurements

    DEFF Research Database (Denmark)

    Villanueva, Héctor; Gómez Arranz, Paula

    The report describes power curve measurements carried out on a given wind turbine. The measurements are carried out in accordance to Ref. [1]. A site calibration has been carried out; see Ref. [2], and the measured flow correction factors for different wind directions are used in the present...

  17. Power Curve Measurements FGW

    DEFF Research Database (Denmark)

    Gómez Arranz, Paula; Villanueva, Héctor

    The report describes power curve measurements carried out on a given wind turbine. The measurements are carried out in accordance to Ref. [1]. A site calibration has been carried out; see Ref. [2], and the measured flow correction factors for different wind directions are used in the present...

  18. Fitting a Gompertz curve

    NARCIS (Netherlands)

    Ph.H.B.F. Franses (Philip Hans)

    1994-01-01

    textabstractIn this paper, a simple Gompertz curve-fitting procedure is proposed. Its advantages include the facts that the stability of the saturation level over the sample period can be checked, and that no knowledge of its value is necessary for forecasting. An application to forecasting the stoc

  19. Gompertz curves with seasonality

    NARCIS (Netherlands)

    Ph.H.B.F. Franses (Philip Hans)

    1994-01-01

    textabstractThis paper considers an extension of the usual Gompertz curve by allowing the parameters to vary over the seasons. This means that, for example, saturation levels can be different over the year. An estimation and testing method is proposed and illustrated with an example.

  20. Power Curve Measurements

    DEFF Research Database (Denmark)

    Gómez Arranz, Paula; Vesth, Allan

    The report describes power curve measurements carried out on a given wind turbine. The measurements are carried out in accordance to Ref. [1]. A site calibration has been carried out; see Ref. [2], and the measured flow correction factors for different wind directions are used in the present...

  1. Power Curve Measurements, FGW

    DEFF Research Database (Denmark)

    Vesth, Allan; Yordanova, Ginka

    The report describes power curve measurements carried out on a given wind turbine. The measurements are carried out in accordance to Ref. [1]. A site calibration has been carried out; see Ref. [2], and the measured flow correction factors for different wind directions are used in the present...

  2. Graphing Polar Curves

    Science.gov (United States)

    Lawes, Jonathan F.

    2013-01-01

    Graphing polar curves typically involves a combination of three traditional techniques, all of which can be time-consuming and tedious. However, an alternative method--graphing the polar function on a rectangular plane--simplifies graphing, increases student understanding of the polar coordinate system, and reinforces graphing techniques learned…

  3. Power Curve Measurements, REWS

    DEFF Research Database (Denmark)

    Villanueva, Héctor; Gómez Arranz, Paula

    This report describes the power curve measurements carried out on a given wind turbine in a chosen period. The measurements were carried out following the measurement procedure in the draft of IEC 61400-12-1 Ed.2 [1], with some deviations mostly regarding uncertainty calculation. Here, the refere...

  4. Power Curve Measurements

    DEFF Research Database (Denmark)

    Federici, Paolo; Kock, Carsten Weber

    This report describes the power curve measurements performed with a nacelle LIDAR on a given wind turbine in a wind farm and during a chosen measurement period. The measurements and analysis are carried out in accordance to the guidelines in the procedure “DTU Wind Energy-E-0019” [1]. The reporting...

  5. Straightening Out Learning Curves

    Science.gov (United States)

    Corlett, E. N.; Morecombe, V. J.

    1970-01-01

    The basic mathematical theory behind learning curves is explained, together with implications for clerical and industrial training, evaluation of skill development, and prediction of future performance. Brief studies of textile worker and typist training are presented to illustrate such concepts as the reduction fraction (a consistent decrease in…

  6. Carbon Lorenz Curves

    NARCIS (Netherlands)

    Groot, L.F.M.

    The purpose of this paper is twofold. First, it exhibits that standard tools in the measurement of income inequality, such as the Lorenz curve and the Gini-index, can successfully be applied to the issues of inequality measurement of carbon emissions and the equity of abatement policies across

  7. Power Curve Measurements

    DEFF Research Database (Denmark)

    Kock, Carsten Weber; Federici, Paolo

    The report describes power curve measurements carried out on a given wind turbine. The measurements are carried out in accordance to Ref. [1]. A site calibration has been carried out; see Ref. [2], and the measured flow correction factors for different wind directions are used in the present...... analyze of power performance of the turbine....

  8. Power Curve Measurements, FGW

    DEFF Research Database (Denmark)

    Kock, Carsten Weber; Vesth, Allan

    The report describes power curve measurements carried out on a given wind turbine. The measurements are carried out in accordance to Ref. [1]. A site calibration has been carried out; see Ref. [2], and the measured flow correction factors for different wind directions are used in the present...... analyze of power performance of the turbine....

  9. Principal Curves on Riemannian Manifolds

    DEFF Research Database (Denmark)

    Hauberg, Søren

    2015-01-01

    Euclidean statistics are often generalized to Riemannian manifolds by replacing straight-line interpolations with geodesic ones. While these Riemannian models are familiar-looking, they are restricted by the inflexibility of geodesics, and they rely on constructions which are optimal only...... in Euclidean domains. We consider extensions of Principal Component Analysis (PCA) to Riemannian manifolds. Classic Riemannian approaches seek a geodesic curve passing through the mean that optimize a criteria of interest. The requirements that the solution both is geodesic and must pass through the mean tend...... from Hastie & Stuetzle to data residing on a complete Riemannian manifold. We show that for elliptical distributions in the tangent of spaces of constant curvature, the standard principal geodesic is a principal curve. The proposed model is simple to compute and avoids many of the pitfalls...

  10. Invariance for Single Curved Manifold

    KAUST Repository

    Castro, Pedro Machado Manhaes de

    2012-08-01

    Recently, it has been shown that, for Lambert illumination model, solely scenes composed by developable objects with a very particular albedo distribution produce an (2D) image with isolines that are (almost) invariant to light direction change. In this work, we provide and investigate a more general framework, and we show that, in general, the requirement for such in variances is quite strong, and is related to the differential geometry of the objects. More precisely, it is proved that single curved manifolds, i.e., manifolds such that at each point there is at most one principal curvature direction, produce invariant is surfaces for a certain relevant family of energy functions. In the three-dimensional case, the associated energy function corresponds to the classical Lambert illumination model with albedo. This result is also extended for finite-dimensional scenes composed by single curved objects. © 2012 IEEE.

  11. KAIT Fermi AGN Light-Curve Reservoir

    Data.gov (United States)

    National Aeronautics and Space Administration — This web page shows the light curves of a total of 163 AGNs that are monitored by KAIT with average cadence of 3 days. These are unfiltered observations; in...

  12. Mapping curved spacetimes into Dirac spinors

    CERN Document Server

    Sabín, Carlos

    2016-01-01

    We show how to transform a Dirac equation in curved spacetime into a Dirac equation in flat spacetime. In particular, we show that any solution of the free massless Dirac equation in a 1+1 dimensional flat spacetime can be transformed via a local phase transformation into a solution of the corresponding Dirac equation in a curved background, where the spacetime metric is encoded into the phase. In this way, the existing quantum simulators of the Dirac equation can naturally incorporate curved spacetimes. As a first example we use our technique to obtain solutions of the Dirac equation in a particular family of interesting spacetimes in 1+1 dimensions.

  13. Estimates for J-curves as submanifolds

    CERN Document Server

    Fish, Joel W

    2009-01-01

    Here we develop some basic analytic tools to study compactness properties of $J$-curves (i.e. pseudo-holomorphic curves) when regarded as submanifolds. Incorporating techniques from the theory of minimal surfaces, we derive an inhomogeneous mean curvature equation for such curves, we establish an extrinsic monotonicity principle for non-negative functions $f$ satisfying $\\Delta f\\geq -c^2 f$, we show that curves locally parameterized as a graph over a coordinate tangent plane have all derivatives a priori bounded in terms of curvature and ambient geometry, and we establish $\\epsilon$-regularity for the square length of their second fundamental forms. These results are all provided for $J$-curves either with or without Lagrangian boundary and hold in almost Hermitian manifolds of arbitrary even dimension (i.e. Riemannian manifolds for which the almost complex structure is an isometry).

  14. Generating artificial light curves: Revisited and updated

    CERN Document Server

    Emmanoulopoulos, D; Papadakis, I E

    2013-01-01

    The production of artificial light curves with known statistical and variability properties is of great importance in astrophysics. Consolidating the confidence levels during cross-correlation studies, understanding the artefacts induced by sampling irregularities, establishing detection limits for future observatories are just some of the applications of simulated data sets. Currently, the widely used methodology of amplitude and phase randomisation is able to produce artificial light curves which have a given underlying power spectral density (PSD) but which are strictly Gaussian distributed. This restriction is a significant limitation, since the majority of the light curves e.g. active galactic nuclei, X-ray binaries, gamma-ray bursts show strong deviations from Gaussianity exhibiting `burst-like' events in their light curves yielding long-tailed probability distribution functions (PDFs). In this study we propose a simple method which is able to precisely reproduce light curves which match both the PSD an...

  15. Remote sensing used for power curves

    Science.gov (United States)

    Wagner, R.; Jørgensen, H. E.; Paulsen, U. S.; Larsen, T. J.; Antoniou, I.; Thesbjerg, L.

    2008-05-01

    : Power curve measurement for large wind turbines requires taking into account more parameters than only the wind speed at hub height. Based on results from aerodynamic simulations, an equivalent wind speed taking the wind shear into account was defined and found to reduce the power standard deviation in the power curve significantly. Two LiDARs and a SoDAR are used to measure the wind profile in front of a wind turbine. These profiles are used to calculate the equivalent wind speed. The comparison of the power curves obtained with the three instruments to the traditional power curve, obtained using a cup anemometer measurement, confirms the results obtained from the simulations. Using LiDAR profiles reduces the error in power curve measurement, when these are used as relative instrument together with a cup anemometer. Results from the SoDAR do not show such promising results, probably because of noisy measurements resulting in distorted profiles.

  16. Carbon Lorenz Curves

    Energy Technology Data Exchange (ETDEWEB)

    Groot, L. [Utrecht University, Utrecht School of Economics, Janskerkhof 12, 3512 BL Utrecht (Netherlands)

    2008-11-15

    The purpose of this paper is twofold. First, it exhibits that standard tools in the measurement of income inequality, such as the Lorenz curve and the Gini-index, can successfully be applied to the issues of inequality measurement of carbon emissions and the equity of abatement policies across countries. These tools allow policy-makers and the general public to grasp at a single glance the impact of conventional distribution rules such as equal caps or grandfathering, or more sophisticated ones, on the distribution of greenhouse gas emissions. Second, using the Samuelson rule for the optimal provision of a public good, the Pareto-optimal distribution of carbon emissions is compared with the distribution that follows if countries follow Nash-Cournot abatement strategies. It is shown that the Pareto-optimal distribution under the Samuelson rule can be approximated by the equal cap division, represented by the diagonal in the Lorenz curve diagram.

  17. Managing curved canals

    Directory of Open Access Journals (Sweden)

    Iram Ansari

    2012-01-01

    Full Text Available Dilaceration is the result of a developmental anomaly in which there has been an abrupt change in the axial inclination between the crown and the root of a tooth. Dilaceration can be seen in both the permanent and deciduous dentitions, and is more commonly found in posterior teeth and in maxilla. Periapical radiographs are the most appropriate way to diagnose the presence of root dilacerations. The controlled regularly tapered preparation of the curved canals is the ultimate challenge in endodontics. Careful and meticulous technique will yield a safe and sufficient enlargement of the curved canals. This article gives a review of the literature and three interesting case reports of root dilacerations.

  18. LCC: Light Curves Classifier

    Science.gov (United States)

    Vo, Martin

    2017-08-01

    Light Curves Classifier uses data mining and machine learning to obtain and classify desired objects. This task can be accomplished by attributes of light curves or any time series, including shapes, histograms, or variograms, or by other available information about the inspected objects, such as color indices, temperatures, and abundances. After specifying features which describe the objects to be searched, the software trains on a given training sample, and can then be used for unsupervised clustering for visualizing the natural separation of the sample. The package can be also used for automatic tuning parameters of used methods (for example, number of hidden neurons or binning ratio). Trained classifiers can be used for filtering outputs from astronomical databases or data stored locally. The Light Curve Classifier can also be used for simple downloading of light curves and all available information of queried stars. It natively can connect to OgleII, OgleIII, ASAS, CoRoT, Kepler, Catalina and MACHO, and new connectors or descriptors can be implemented. In addition to direct usage of the package and command line UI, the program can be used through a web interface. Users can create jobs for ”training” methods on given objects, querying databases and filtering outputs by trained filters. Preimplemented descriptors, classifier and connectors can be picked by simple clicks and their parameters can be tuned by giving ranges of these values. All combinations are then calculated and the best one is used for creating the filter. Natural separation of the data can be visualized by unsupervised clustering.

  19. Dynamics of curved fronts

    CERN Document Server

    Pelce, Pierre

    1989-01-01

    In recent years, much progress has been made in the understanding of interface dynamics of various systems: hydrodynamics, crystal growth, chemical reactions, and combustion. Dynamics of Curved Fronts is an important contribution to this field and will be an indispensable reference work for researchers and graduate students in physics, applied mathematics, and chemical engineering. The book consist of a 100 page introduction by the editor and 33 seminal articles from various disciplines.

  20. Estimating Corporate Yield Curves

    OpenAIRE

    Antionio Diaz; Frank Skinner

    2001-01-01

    This paper represents the first study of retail deposit spreads of UK financial institutions using stochastic interest rate modelling and the market comparable approach. By replicating quoted fixed deposit rates using the Black Derman and Toy (1990) stochastic interest rate model, we find that the spread between fixed and variable rates of interest can be modeled (and priced) using an interest rate swap analogy. We also find that we can estimate an individual bank deposit yield curve as a spr...

  1. Conservative neck dissection in oral cancer patients: a 5 year retrospective study in Malaysia.

    Science.gov (United States)

    Balasundram, Sathesh; Mustafa, Wan Mahadzir Wan; Ip, Jolene; Adnan, Tassha Hilda; Supramaniam, Premaa

    2012-01-01

    The impact of ablative oral cancer surgery was studied, with particular reference to recurrence and nodal metastasis, to assess survival probability and prognostic indicators and to elucidate if ethnicity influences the survival of patients. Patients who underwent major ablative surgery of the head and neck region with neck dissection were identified and clinical records were assessed. Inclusion criteria were stage I-IV oral and oropharyngeal malignancies necessitating resection with or without radiotherapy from 2004 to 2009. All individuals had a pre-operative assessment prior to the surgery. The post operative assessment period ranged from 1 year to 5 years. Survival distributions were analyzed using Kaplan-Meier curves. 87 patients (males:38%; females:62%) were included in this study, with an age range of 21-85 years. Some 78% underwent neck dissections while 63% had surgery and radiotherapy. Nodal recurrence was detected in 5.7% while 20.5% had primary site recurrence within the study period. Kaplan-Meier survival analysis revealed that the median survival time was 57 months. One year overall survival (OS) rate was 72.7% and three year overall survival rate dropped to 61.5%. On OS analysis, the log-rank test showed a significant difference of survival between Malay and Chinese patients (Bonferroni correction p=0.033). Recurrence-free survival (RFS) analysis revealed that 25% of the patients have reached the event of recurrence at 46 months. One year RFS rate was 85.2% and the three year survival rate was 76.1%. In the RFS analysis, the log-rank test showed a significant difference in the event of recurrence and nodal metastasis (p<0.001). Conservative neck is effective, in conjunction with postoperative radiotherapy, for control of neck metastases. Ethnicity appears to influence the survival of the patients, but a prospective trial is required to validate this.

  2. High lncRNA H19 expression as prognostic indicator: data mining in female cancers and polling analysis in non-female cancers

    Science.gov (United States)

    Peng, Li; Liu, Zhao-Yang; Li, Wen-Ling; Zhang, Chao-Yang; Zhang, Ya-Qin; Pan, Xi; Chen, Jun; Li, Yue-Hui

    2017-01-01

    Upregulation of lncRNA H19 expression is associated with an unfavorable prognosis in some cancers. However, the prognostic value of H19 in female-specific cancers has remained uncharacterized. In this study, the prognostic power of high H19 expression in female cancer patients from the TCGA datasets was analyzed using Kaplan-Meier survival curves and Cox's proportional hazard modeling. In addition, in a meta-analysis of non-female cancer patients from TCGA datasets and 12 independent studies, hazard ratios (HRs) with 95% confidence interval (CI) for overall survival (OS) and disease-free survival (DFS)/relapse-free survival (RFS)/metastasis-free survival (MFS)/progression-free survival (PFS) were pooled to assess the prognostic value of high H19 expression. Kaplan-Meier analysis revealed that patients with uterine corpus cancer and higher H19 expression had a shorter OS (HR=2.710, p<0.05), while females with cervical cancer and increased H19 expression had a shorter RFS (HR=2.261, p<0.05). Multivariate Cox regression analysis showed that high H19 expression could independently predict a poorer prognosis in cervical cancer patients (HR=4.099, p<0.05). In the meta-analysis, patients with high H19 expression showed a poorer outcome in non-female cancer (p<0.05). These results suggest that high lncRNA H19 expression is predictive of an unfavorable prognosis in two female cancers (uterine corpus endometrioid cancer and cervical cancer) as well as in non-female cancer patients. PMID:27926484

  3. A comparison of medium-term survival between peritoneal dialysis and haemodialysis in accordance with the initial vascular access.

    Science.gov (United States)

    García-Cantón, César; Rufino-Hernández, Juana M; Vega-Díaz, Nicanor; Pérez-Borges, Patricia; Bosch-Benítez-Parodi, Elvira; Saavedra, Pedro; García-Gómez, Carolina; Marrero-Robayna, Silvia; Maceira-Cruz, Benito; Rodríguez-Pérez, José C; Checa-Andrés, M Dolores

    2013-01-01

    A study published in 2011 showed that patients in the Canary Islands, who were incident in peritoneal dialysis (PD) had better survival than those who were incident in hemodialysis (HD). Since initiating hemodialysis with central venous catheter is associated with worse prognosis, it would be possible that the initial vascular access influences the results of survival comparison between both groups. To conduct a comparative medium-term survival study of patients incident in renal replacement therapy with different modalities in our community, classifying those incident in hemodialysis according to the initial vascular access: established arteriovenous vascular access or central venous catheter. Retrospective longitudinal cohort study including all patients who were incident in renal replacement therapy between January 2005 and December 2010, with follow-up until December 2011, in three large hospitals of the Canary Islands. Patients were classified according to the initial modality: PD, HD with established vascular access (HD-FAV) or HD with central venous catheter (HD-Cat). Kaplan-Meier survival curves were estimated for each group and a Cox proportional hazards survival model was used to estimate relative mortality risk for DP as compared to HD-FAV and HD-Cat, adjusting for age and Charlson comorbidity index. An equivalent analysis was then conducted on subgroups defined by age or by the presence of diabetes. 1110 patients were included, with a median age of 63 years, 56% of them were diabetic. A Kaplan-Meier analysis showed better survival for PD (66 months) as compared to HD-Cat (41 months), Log Rank pcatheter, while no differences were found between PD and HD with established vascular access. These results could suggest that patients in our community, for whom a vascular access cannot be achieved in predialysis, could have better survival if PD is offered as initial technique, at least until a vascular access is available.

  4. Statins Reduces the Risk of Dementia in Patients with Late-Onset Depression: A Retrospective Cohort Study.

    Directory of Open Access Journals (Sweden)

    Ya-Hsu Yang

    Full Text Available Patients with late-onset depression (LOD have been reported to run a higher risk of subsequent dementia. The present study was conducted to assess whether statins can reduce the risk of dementia in these patients.We used the data from National Health Insurance of Taiwan during 1996-2009. Standardized Incidence Ratios (SIRs were calculated for LOD and subsequent dementia. The criteria for LOD diagnoses included age ≥65 years, diagnosis of depression after 65 years of age, at least three service claims, and treatment with antidepressants. The time-dependent Cox proportional hazards model was applied for multivariate analyses. Propensity scores with the one-to-one nearest-neighbor matching model were used to select matching patients for validation studies. Kaplan-Meier curve estimate was used to measure the group of patients with dementia living after diagnosis of LOD.Totally 45,973 patients aged ≥65 years were enrolled. The prevalence of LOD was 12.9% (5,952/45,973. Patients with LOD showed to have a higher incidence of subsequent dementia compared with those without LOD (Odds Ratio: 2.785; 95% CI 2.619-2.958. Among patients with LOD, lipid lowering agent (LLA users (for at least 3 months had lower incidence of subsequent dementia than non-users (Hazard Ratio = 0.781, 95% CI 0.685-0.891. Nevertheless, only statins users showed to have reduced risk of dementia (Hazard Ratio = 0.674, 95% CI 0.547-0.832 while other LLAs did not, which was further validated by Kaplan-Meier estimates after we used the propensity scores with the one-to-one nearest-neighbor matching model to control the confounding factors.Statins may reduce the risk of subsequent dementia in patients with LOD.

  5. Nutritional predictors of mortality in prevalent peritoneal dialysis patients.

    Science.gov (United States)

    Malgorzewicz, Sylwia; Chmielewski, Michal; Kaczkan, Malgorzata; Borek, Paulina; Lichodziejewska-Niemierko, Monika; Rutkowski, Boleslaw

    2016-01-01

    Malnutrition remains one of the major predictors of mortality in peritoneal dialysis (PD) patients. The aim of the study was to evaluate the nutritional status of prevalent PD patients, and to determine the best predictors of outcome among anthropometric and laboratory indices of nutrition. The study included 106 prevalent PD patients from a single university-based unit. Anthropometric assessment at baseline included: body mass, body mass index (BMI), skinfold thickness, lean body mass (LBM), content of body fat (%F), mid-arm muscle circumference (MAMC). Laboratory analysis comprised of albumin and total cholesterol. Additionally, each patient underwent a subjective global assessment (SGA). The patients were followed for 36 months. Survival analyses were made with the Kaplan-Meier survival curve and the Cox proportional hazard model. Following SGA, malnutrition was diagnosed in 30 (28%) patients. Importantly, eight of the malnourished patients (27%) were nevertheless overweight or obese. Body weight and BMI showed complete lack of association with the outcome. In Kaplan-Meier analysis low: LBM, MAMC, albumin and cholesterol were significantly related to mortality. Cox analysis revealed that, following adjustment, LBM below median was independently associated with poor outcome (hazard ratio [HR] 3.15, 95% confidence interval [CI] 1.17-8.49, p=0.02). Moreover, the lowest quartile of total cholesterol showed independent association with mortality (HR 8.68, CI 2.14-35.21, p<0.01). Malnutrition is prevalent in patients undergoing PD, and overweight/obesity does not preclude its appearance. The most valuable nutritional indices in predicting outcome in this cohort were LBM and total cholesterol concentration.

  6. Prognostic value of DNA alterations on chromosome 17p13.2 for intrahepatic cholangiocarcinoma

    Institute of Scientific and Technical Information of China (English)

    Ubol Chuensumran; Sopit Wongkham; Chawalit Pairojkul; Siri Chauin; Songsak Petmitr

    2007-01-01

    AIM: To characterize and evaluate DNA alterations among intrahepatic cholangiocarcinoma (ICC) patients.METHODS: DNA from tumor and corresponding normal tissues of 52 patients was amplified with 33 arbitrary primers. The DNA fragment that alters most frequently in ICC was cloned, sequenced, and identified by comparison with known nucleotide sequences in the genome database (www.ncbi.nlm.nih.gov). The DNA copy numbers of the allelic alterations in cholangiocarcinoma were determined by quantitative real-time PCR and interpreted as allelic loss or DNA amplification by comparison with the reference gene. Associations between allelic imbalance and clinicopathological parameters of ICC patients were evaluated by x2-test.The Kaplan-Meier method was used to analyze survival rates.RESULTS: From 33 primers, an altered DNA fragment (518 bp) amplified from BC17 random primer was found frequently in the tumors analyzed and mapped to chromosome 17p13.2. Sixteen of 52 (31%) cases showed DNA amplification, while 7 (13%) showed allelic loss. Interestingly, DNA amplification on chromosome 17p13.2 was associated with a good prognosis, median survival time (wk) of amp vs no amp was 44.14 vs 24.14,P = 0.002; whereas allelic loss of this DNA sequence corresponded with a poor prognosis, median survival time (wk) of loss vs no loss was 18.00 vs 28.71, P =0.019). Moreover, Kaplan-Meier curves comparing the DNA alterations with survival depicted highly significant separation that the median survival time equal to DNA amplification, allelic loss, and normal was 44.14 wk,18.00 wk, and 24.29 wk, respectively (P = 0.005).CONCLUSION: Alterations in the DNA sequence on chromosome 17p13.2 may be involved in cholangiocarcinogenesis, and could be used as a prognostic marker in the treatment of ICC patients.

  7. Principal -bundles on Nodal Curves

    Indian Academy of Sciences (India)

    Usha N Bhosle

    2001-08-01

    Let be a connected semisimple affine algebraic group defined over . We study the relation between stable, semistable -bundles on a nodal curve and representations of the fundamental group of . This study is done by extending the notion of (generalized) parabolic vector bundles to principal -bundles on the desingularization of and using the correspondence between them and principal -bundles on . We give an isomorphism of the stack of generalized parabolic bundles on with a quotient stack associated to loop groups. We show that if is simple and simply connected then the Picard group of the stack of principal -bundles on is isomorphic to ⊕ , being the number of components of .

  8. pFAK-Y397 overexpression as both a prognostic and a predictive biomarker for patients with metastatic osteosarcoma

    Science.gov (United States)

    Thanapprapasr, Kamolrat; Nartthanarung, Adisak; Thanapprapasr, Duangmani

    2017-01-01

    Focal adhesion kinase (FAK) is important for tumor cell survival and metastasis in various cancers. However, its expression and prognostic value in patients with metastatic osteosarcoma remain unknown. We investigated the expression of FAK and its phosphorylated form (pFAK-Y397) in osteosarcoma tissues from 53 patients by immunohistochemistry and evaluated their correlations with clinicopathologic characteristics and outcomes. The prognostic values were assessed using Kaplan-Meier survival and Cox regression analyses. Total FAK and pFAK-Y397 were overexpressed in 48 (90.6%) and 33 (62.3%) cases, respectively. pFAK-Y397 overexpression was correlated with poor histologic response after neoadjuvant chemotherapy in patients with osteosarcoma regardless of the presence of metastasis or not. Kaplan-Meier curve showed that patients with metastatic osteosarcoma with pFAK-Y397 overexpression had significantly worse overall survival (OS) than those with non-overexpression (P = 0.044). Multivariate Cox regression analysis confirmed pFAK-Y397 overexpression as an independent prognostic predictor for OS and post metastases OS (PMOS) (P = 0.017, P = 0.006, respectively). Age at diagnosis was also an independent indicator for PMOS (P = 0.003). However, total FAK expression was not correlated with any clinicopathologic characteristics or OS in patients with metastatic osteosarcoma. In conclusion, our findings identified FAK as a common aberrant protein overexpression in various subtypes of osteosarcoma. pFAK-Y397 overexpression can be used as a prognostic biomarker predicting poor OS for patients with metastatic osteosarcoma, and the expression of pFAK-Y397 differentiated good and poor responders to neoadjuvant chemotherapy. PMID:28846700

  9. Angioplasty for coarctation in different aged patients.

    Science.gov (United States)

    Walhout, Ronald J; Lekkerkerker, Jaco C; Ernst, Sjef M P G; Hutter, Paul A; Plokker, Thijs H W M; Meijboom, Erik J

    2002-07-01

    Differences in the indication and outcome of balloon angioplasty for coarctation in children and adults have not been elucidated sufficiently. The results of balloon angioplasty for coarctation are compared between pediatric and adult age groups. Balloon angioplasty for coarctation of the aorta was performed in 85 patients who were classified according to age and native coarctation/recoarctation. Groups A (patients aged or =16 years, n = 17) included patients with native coarctations. Groups rCoA A (patients aged or =16 years, n = 3) included patients with recoarctations. Follow-up included 2-dimensional Doppler scanning echocardiography and additional angiography or magnetic resonance imaging. Gradient reductions in groups were compared by use of the independent-samples t test. Kaplan-Meier and log-rank analyses were performed as a means of comparing long-term outcome. No mortality occurred. Immediate success was equal in groups A, B, and rCoA A (94%). Dilatation was unsuccessful in 2 patients in group rCoA B. Pressure gradients decreased 23 mm Hg in group A, 31 mm Hg in group B, 18 mm Hg in group rCoA A, and 11 mm Hg in group rCoA B. Pressure gradient drops, compared between groups A and B, showed a significant difference (P <.001). The length of hospital stay ranged from 12 to 48 hours. The period of follow-up ranged from 6 months to 12 years (mean, 4.9 years). Kaplan-Meier curves of groups A and B are not different, as determined by means of log-rank analysis. No aneurysm formation was encountered. The results of balloon angioplasty for native coarctation in both selected children and adults are excellent. In recoarctation, we recommend balloon angioplasty in the pediatric patients.

  10. Good outcome of total hip replacement in patients with cerebral palsy

    Science.gov (United States)

    King, Garry; Hunt, Linda P; Wilkinson, J Mark; Blom, Ashley W

    2016-01-01

    Background and purpose — People with cerebral palsy (CP) often have painful deformed hips, but they are seldom treated with hip replacement as the surgery is considered to be high risk. However, few data are available on the outcome of hip replacement in these patients. Patients and methods — We linked Hospital Episode Statistics (HES) records to the National Joint Registry for England and Wales to identify 389 patients with CP who had undergone hip replacement. Their treatment and outcomes were compared with those of 425,813 patients who did not have CP. Kaplan-Meier estimates were calculated to describe implant survivorship and the curves were compared using log-rank tests, with further stratification for age and implant type. Reasons for revision were quantified as patient-time incidence rates (PTIRs). Nationally collected patient-reported outcomes (PROMS) before and 6 months after operation were compared if available. Cumulative mortality (Kaplan-Meier) was estimated at 90 days and at 1, 3, and 5 years. Results — The cumulative probability of revision at 5 years post-surgery was 6.4% (95% CI: 3.8–11) in the CP cohort as opposed to 2.9% (CI 2.9–3%) in the non-CP cohort (p < 0.001). Patient-reported outcomes showed that CP patients had worse pain and function preoperatively, but had equivalent postoperative improvement. The median improvement in Oxford hip score at 6 months was 23 (IQR: 14–28) in CP and it was 21 (14–28) in non-CP patients. 91% of CP patients reported good or excellent satisfaction with their outcome. The cumulative probability of mortality for CP up to 7 years was similar to that in the controls after stratification for age and sex. Interpretation — Hip replacement for cerebral palsy appears to be safe and effective, although implant revision rates are higher than those in patients without cerebral palsy. PMID:26863583

  11. Diagnostic and prognostic value of serum nitric oxide, tumor necrosis factor-alpha, basic fibroblast growth factor and copper as angiogenic markers in premenopausal breast cancer patients: a case-control study.

    Science.gov (United States)

    Hewala, T I; Abd El-Moneim, N A; Ebied, S Abd El-Moneim; Sheta, M I; Soliman, K; Abu-Elenean, A

    2010-01-01

    Many studies demonstrate that increased microvessel density (MVD) surrounding primary tumour is associated with decreased overall survival in patients with breast cancer. This study compares the diagnostic and prognostic values of the angiogenic serum factors nitric oxide (NO), tumour necrosis factor-alpha (TNFalpha), basic fibroblast growth factor (bFGF) and copper with those of serum CA15-3 as the standard tumour marker in breast cancer patients. Microvessel density was estimated in CD31-immunostained sections from breast cancer patients. Before surgery, NO, TNFalpha, bFGF, copper and CA 15-3 were measured in serum samples from 30 premenopausal breast cancer patients in comparison with 15 healthy controls. The diagnostic values of the assayed parameters were compared using receiver operating characteristic (ROC) curve analysis. Univariate survival analysis of patients was assessed using the Kaplan-Meier method. Breast cancer tissues showed higher MVD than did normal breast tissues adjacent to the tumour (P = 0.008). Before surgery, tumour MVD correlated significantly with serum NO, TNFalpha, bFGF and copper (r = 0.458, P = .011; r = 0.379, P = .039; r = 0.513, P = .004 and r = 0.613, P = 0.000, respectively). Serum NO, TNFalpha, bFGF, copper and CA 15-3 levels in patients were significantly elevated compared with controls (P = 0.011, P = 0.004, P = 0.039, P = 0.000 and P = 0.001, respectively). Kaplan-Meier analysis revealed that patients with elevated serum TNFalpha, CA 15-3 and copper (P = 0.035, P = 0.040, P = 0.0339, respectively) had an overall survival significantly shorter than those who had lower levels of these parameters. These data suggest that serum TNFalpha, CA 15-3 and copper are useful predictive markers for overall survival in premenopausal breast cancer patients.

  12. Does urothelial cancer of bladder behave differently in young patients?

    Institute of Scientific and Technical Information of China (English)

    WANG Zhi-hua; LI You-yuan; HU Zhi-quan; ZHU Hui; ZHUANG Qian-yuan; QI Yong; YE Zhang-qun

    2012-01-01

    Background Bladder urothelial cancer has been diagnosed at an increasing rate among young adults in China while the clinical outcomes remain highly controversial.To optimize the management of young patients with bladder cancer,we examined whether bladder urothelial cancer in young patients behaved differently from that in the elder patients.Methods From 1994 to 2008,a database of bladder urothelial cancer patients at a major tertiary medical center was retrospectively reviewed.The clinical and pathological parameters of patients who were less than 40 years of age and a series of patients older than 40 years of age as the control group during the same period were compared.A survival analysis was performed using the Kaplan-Meier method and log-rank test,and Cox regression was performed to identify clinical parameters that affected the clinic outcomes.Results Young bladder cancer patients had a lower male-to-female ratio and were less likely to have advanced stages and high-grade cancers at the initial diagnosis.Tumors in young bladder cancer patients tended to be less multifocal at diagnosis.In addition,young patients had a lower recurrence rate and longer recurrence interval than older patients.The Kaplan-Meier curve and Log-rank test showed that young patients had significantly better cancer specific survival than old patients.The univariats and multivariate Cox regression analysis revealed that tumor grade is the sole predictor for tumor recurrence in young patients.Conclusions Young patients with bladder cancer have favorable pathological features and clinical outcomes than older patients.These findings argue for more conservative management approaches for young patients with bladder cancer.

  13. Curved PVDF airborne transducer.

    Science.gov (United States)

    Wang, H; Toda, M

    1999-01-01

    In the application of airborne ultrasonic ranging measurement, a partially cylindrical (curved) PVDF transducer can effectively couple ultrasound into the air and generate strong sound pressure. Because of its geometrical features, the ultrasound beam angles of a curved PVDF transducer can be unsymmetrical (i.e., broad horizontally and narrow vertically). This feature is desired in some applications. In this work, a curved PVDF air transducer is investigated both theoretically and experimentally. Two resonances were observed in this transducer. They are length extensional mode and flexural bending mode. Surface vibration profiles of these two modes were measured by a laser vibrometer. It was found from the experiment that the surface vibration was not uniform along the curvature direction for both vibration modes. Theoretical calculations based on a model developed in this work confirmed the experimental results. Two displacement peaks were found in the piezoelectric active direction of PVDF film for the length extensional mode; three peaks were found for the flexural bending mode. The observed peak positions were in good agreement with the calculation results. Transient surface displacement measurements revealed that vibration peaks were in phase for the length extensional mode and out of phase for the flexural bending mode. Therefore, the length extensional mode can generate a stronger ultrasound wave than the flexural bending mode. The resonance frequencies and vibration amplitudes of the two modes strongly depend on the structure parameters as well as the material properties. For the transducer design, the theoretical model developed in this work can be used to optimize the ultrasound performance.

  14. Magnetism in curved geometries

    Science.gov (United States)

    Streubel, Robert; Fischer, Peter; Kronast, Florian; Kravchuk, Volodymyr P.; Sheka, Denis D.; Gaididei, Yuri; Schmidt, Oliver G.; Makarov, Denys

    2016-09-01

    Extending planar two-dimensional structures into the three-dimensional space has become a general trend in multiple disciplines, including electronics, photonics, plasmonics and magnetics. This approach provides means to modify conventional or to launch novel functionalities by tailoring the geometry of an object, e.g. its local curvature. In a generic electronic system, curvature results in the appearance of scalar and vector geometric potentials inducing anisotropic and chiral effects. In the specific case of magnetism, even in the simplest case of a curved anisotropic Heisenberg magnet, the curvilinear geometry manifests two exchange-driven interactions, namely effective anisotropy and antisymmetric exchange, i.e. Dzyaloshinskii-Moriya-like interaction. As a consequence, a family of novel curvature-driven effects emerges, which includes magnetochiral effects and topologically induced magnetization patterning, resulting in theoretically predicted unlimited domain wall velocities, chirality symmetry breaking and Cherenkov-like effects for magnons. The broad range of altered physical properties makes these curved architectures appealing in view of fundamental research on e.g. skyrmionic systems, magnonic crystals or exotic spin configurations. In addition to these rich physics, the application potential of three-dimensionally shaped objects is currently being explored as magnetic field sensorics for magnetofluidic applications, spin-wave filters, advanced magneto-encephalography devices for diagnosis of epilepsy or for energy-efficient racetrack memory devices. These recent developments ranging from theoretical predictions over fabrication of three-dimensionally curved magnetic thin films, hollow cylinders or wires, to their characterization using integral means as well as the development of advanced tomography approaches are in the focus of this review.

  15. Adaptive B-snake for planar curve approximation

    Institute of Scientific and Technical Information of China (English)

    CHENG Si-yuan; ZHANG Xiang-wei; HUANG Man-hui

    2005-01-01

    An adaptive B-spline active contour model for planar curve approximation is proposed. Starting with an initial B-spline curve, the finite element method is adopted to make the active B-spline curve converge towards the target curve without the need of data points parameterization. A strategy of automatic control point insertion during the B-spline active contour deformation, adaptive to the shape of the planar curve, is also given. Experimental results show that this method is efficient and accurate in planar curve approximation.

  16. Improvement of energy model based on cubic interpolation curve

    Institute of Scientific and Technical Information of China (English)

    Li Peipei; Li Xuemei; and Wei Yu

    2012-01-01

    In CAGD and CG, energy model is often used to control the curves and surfaces shape. In curve/surface modeling, we can get fair curve/surface by minimizing the energy of curve/surface. However, our research indicates that in some cases we can't get fair curves/surface using the current energy model. So an improved energy model is presented in this paper. Examples are also included to show that fair curves can be obtained using the improved energy model.

  17. Do labour supply and demand curves exist?

    OpenAIRE

    Fleetwood, S.

    2014-01-01

    The objective of this paper is to show that circumstantial and empirical evidence for the existence of labour supply and demand curves is at best inconclusive and at worst casts doubt on their existence. Because virtually all orthodox models of labour markets, simple and complex, are built upon the foundation stones of labour supply and demand curves, these models lack empirically supported foundations. Orthodox labour economists must, therefore, either provide stronger evidence or stop using...

  18. Three-body choreographies in given curves

    Energy Technology Data Exchange (ETDEWEB)

    Ozaki, Hiroshi [General Education Program Center, Tokai University, 317 Nishino, Numazu, Shizuoka 410-0395 (Japan); Fukuda, Hiroshi; Fujiwara, Toshiaki [College of Liberal Arts and Sciences, Kitasato University, 1-15-1 Kitasato, Sagamihara, Kanagawa 228-8555 (Japan)], E-mail: ozaki@keyaki.cc.u-tokai.ac.jp, E-mail: fukuda@kitasato-u.ac.jp, E-mail: fujiwara@kitasato-u.ac.jp

    2009-10-02

    As shown by Johannes Kepler in 1609, in the two-body problem, the shape of the orbit, a given ellipse, and a given non-vanishing constant angular momentum determine the motion of the planet completely. Even in the three-body problem, in some cases, the shape of the orbit, conservation of the center of mass and a constant of motion (the angular momentum or the total energy) determine the motion of the three bodies. We show, by a geometrical method, that choreographic motions, in which equal mass three bodies chase each other around the same curve, will be uniquely determined for the following two cases. (i) Convex curves that have point symmetry and non-vanishing angular momentum are given. (ii) Eight-shaped curves which are similar to the curve for the figure-eight solution and the energy constant are given. The reality of the motion should be tested whether the motion satisfies an equation of motion or not. Extensions of the method for generic curves are shown. The extended methods are applicable to generic curves which do not have point symmetry. Each body may have its own curve and its own non-vanishing masses.

  19. Curved-region-based ridge frequency estimation and curved Gabor filters for fingerprint image enhancement.

    Science.gov (United States)

    Gottschlich, Carsten

    2012-04-01

    Gabor filters (GFs) play an important role in many application areas for the enhancement of various types of images and the extraction of Gabor features. For the purpose of enhancing curved structures in noisy images, we introduce curved GFs that locally adapt their shape to the direction of flow. These curved GFs enable the choice of filter parameters that increase the smoothing power without creating artifacts in the enhanced image. In this paper, curved GFs are applied to the curved ridge and valley structures of low-quality fingerprint images. First, we combine two orientation-field estimation methods in order to obtain a more robust estimation for very noisy images. Next, curved regions are constructed by following the respective local orientation. Subsequently, these curved regions are used for estimating the local ridge frequency. Finally, curved GFs are defined based on curved regions, and they apply the previously estimated orientations and ridge frequencies for the enhancement of low-quality fingerprint images. Experimental results on the FVC2004 databases show improvements of this approach in comparison with state-of-the-art enhancement methods.

  20. Rigid curves on $\\bar M_{0,n}$ and arithmetic breaks

    CERN Document Server

    Castravet, Ana-Maria

    2011-01-01

    A result of Keel and McKernan states that a hypothetical counterexample to the F-conjecture must come from rigid curves on $\\bar {M}_{0,n}$ that intersect the interior. We exhibit several ways of constructing rigid curves. In all our examples, a reduction mod p argument shows that the classes of the rigid curves that we construct can be decomposed as sums of F-curves.

  1. Superfluids in Curved Spacetime

    CERN Document Server

    Villegas, Kristian Hauser A

    2015-01-01

    Superfluids under an intense gravitational field are typically found in neutron star and quark star cores. Most treatments of these superfluids, however, are done in a flat spacetime background. In this paper, the effect of spacetime curvature on superfluidity is investigated. An effective four-fermion interaction is derived by integrating out the mediating scalar field. The fermions interacting via the mediating gauge vector bosons is also discussed. Two possible cases are considered in the mean-field treatment: antifermion-fermion and fermion-fermion pairings. An effective action, quadratic in fermion field, and a self-consistent equation are derived for both cases. The effective Euclidean action and the matrix elements of the heat kernel operator, which are very useful in curved-spacetime QFT calculations, are derived for the fermion-fermion pairing. Finally, explicit numerical calculation of the gravitational correction to the pairing order parameter is performed for the scalar superfluid case. It is foun...

  2. Evolutes of Hyperbolic Plane Curves

    Institute of Scientific and Technical Information of China (English)

    Shyuichi IZUMIYA; Dong He PEI; Takashi SANO; Erika TORII

    2004-01-01

    We define the notion of evolutes of curves in a hyperbolic plane and establish the relationships between singularities of these subjects and geometric invariants of curves under the action of the Lorentz group. We also describe how we can draw the picture of an evolute of a hyperbolic plane curve in the Poincar(e) disk.

  3. The Arithmetic of Elliptic Curves

    CERN Document Server

    Silverman, Joseph H

    2009-01-01

    Treats the arithmetic theory of elliptic curves in its modern formulation, through the use of basic algebraic number theory and algebraic geometry. This book discusses the necessary algebro-geometric results, and offers an exposition of the geometry of elliptic curves, and the formal group of an elliptic curve.

  4. Curved-Duct

    Directory of Open Access Journals (Sweden)

    Je Hyun Baekt

    2000-01-01

    Full Text Available A numerical study is conducted on the fully-developed laminar flow of an incompressible viscous fluid in a square duct rotating about a perpendicular axis to the axial direction of the duct. At the straight duct, the rotation produces vortices due to the Coriolis force. Generally two vortex cells are formed and the axial velocity distribution is distorted by the effect of this Coriolis force. When a convective force is weak, two counter-rotating vortices are shown with a quasi-parabolic axial velocity profile for weak rotation rates. As the rotation rate increases, the axial velocity on the vertical centreline of the duct begins to flatten and the location of vorticity center is moved near to wall by the effect of the Coriolis force. When the convective inertia force is strong, a double-vortex secondary flow appears in the transverse planes of the duct for weak rotation rates but as the speed of rotation increases the secondary flow is shown to split into an asymmetric configuration of four counter-rotating vortices. If the rotation rates are increased further, the secondary flow restabilizes to a slightly asymmetric double-vortex configuration. Also, a numerical study is conducted on the laminar flow of an incompressible viscous fluid in a 90°-bend square duct that rotates about axis parallel to the axial direction of the inlet. At a 90°-bend square duct, the feature of flow by the effect of a Coriolis force and a centrifugal force, namely a secondary flow by the centrifugal force in the curved region and the Coriolis force in the downstream region, is shown since the centrifugal force in curved region and the Coriolis force in downstream region are dominant respectively.

  5. Quantum Curves and $D$-Modules

    CERN Document Server

    Dijkgraaf, Robbert; Sulkowski, Piotr

    2009-01-01

    In this article we continue our study of chiral fermions on a quantum curve. This system is embedded in string theory as an I-brane configuration, which consists of D4 and D6-branes intersecting along a holomorphic curve in a complex surface, together with a B-field. Mathematically, it is described by a holonomic D-module. Here we focus on spectral curves, which play a prominant role in the theory of (quantum) integrable hierarchies. We show how to associate a quantum state to the I-brane system, and subsequently how to compute quantum invariants. As a first example, this yields an insightful formulation of (double scaled as well as general Hermitian) matrix models. Secondly, our formalism elegantly reconstructs the complete dual Nekrasov-Okounkov partition function from a quantum Seiberg-Witten curve.

  6. Quantum curves and Script D-modules

    Science.gov (United States)

    Dijkgraaf, Robbert; Hollands, Lotte; Sułkowski, Piotr

    2009-11-01

    In this article we continue our study of chiral fermions on a quantum curve. This system is embedded in string theory as an I-brane configuration, which consists of D4 and D6-branes intersecting along a holomorphic curve in a complex surface, together with a B-field. Mathematically, it is described by a holonomic Script D-module. Here we focus on spectral curves, which play a prominent role in the theory of (quantum) integrable hierarchies. We show how to associate a quantum state to the I-brane system, and subsequently how to compute quantum invariants. As a first example, this yields an insightful formulation of (double scaled as well as general Hermitian) matrix models. Secondly, we formulate c = 1 string theory in this language. Finally, our formalism elegantly reconstructs the complete dual Nekrasov-Okounkov partition function from a quantum Seiberg-Witten curve.

  7. Halpha rotation curves the soft core question

    CERN Document Server

    Marchesini, D; Chincarini, G L; Firmani, C; Conconi, P; Molinari, E; Zacchei, A

    2002-01-01

    We present good resolution Halpha rotation curves of 6 galaxies: late-type dwarf and low surface brightness galaxies (LSB) for which accurate HI rotation curves are available from the literature. Observations are carried out at Telescopio Nazionale Galileo (TNG). For LSB F583-1 an innovative dispersing element was used, the Volume Phase Holographic (VPH) with a dispersion of about 0.35 A pxl^{-1}. From our analysis we find good agreement between the Halpha data and the HI observations concluding that the HI data for these galaxies suffer very little from beam smearing. We show that the optical rotation curves of these dark matter dominated galaxies are best fitted by the Burkert profile. In the center of galaxies, where the N-body simulations predict cusp cores and fast rising rotation curves, our data seem to be in better agreement with the presence of soft cores.

  8. Automorphisms of double coverings of curves

    CERN Document Server

    Torres, F

    1994-01-01

    We study automorphisms of curves that commute with each other. We prove that the order and the number of fixed points of one of them satisfy certain relations involving those of the other. Then, we specialize our results to the case of double coverings of curves. For instance, if the genus of the curve is at least 4\\gamma+2 and \\gamma \\geqq 1 (\\gamma = the genus of the covered curve) we prove that the order of an automorphism is bounded above by 2\\gamma+1 (resp. 4\\gamma+2) provided it is prime (resp. it has at least five fixed points). We also improve Farkas' bound on the number of fixed points namely 4\\gamma+4 by showing that it involves the order of the automorphism except in the case of even order when such an improvement is obtained provided the automorphism and the \\gamma-involution has at least one common fixed point.

  9. Contracts, Phillips Curve and Monetary Policy

    Directory of Open Access Journals (Sweden)

    Félix Jiménez

    2016-02-01

    Full Text Available This paper shows how to obtain a short run aggregate supply curve when there are explicit orimplicit contracts. In the same way it is possible to obtain an expectation augmented Phillips curve. Then, a monetary policy is incorporated to the short run aggregate supply curve or to the Phillips curve in order to model the Central Bank reaction when the actual inflation deviates from the target inflation. Then a model with a Central Bank welfare lost function is developed in order to obtain an optimal monetary policy rule which modifies the synthetic version of the Taylor Rule. This model allows making short run comparative static analyses.

  10. Probing exoplanet clouds with optical phase curves.

    Science.gov (United States)

    Muñoz, Antonio García; Isaak, Kate G

    2015-11-01

    Kepler-7b is to date the only exoplanet for which clouds have been inferred from the optical phase curve--from visible-wavelength whole-disk brightness measurements as a function of orbital phase. Added to this, the fact that the phase curve appears dominated by reflected starlight makes this close-in giant planet a unique study case. Here we investigate the information on coverage and optical properties of the planet clouds contained in the measured phase curve. We generate cloud maps of Kepler-7b and use a multiple-scattering approach to create synthetic phase curves, thus connecting postulated clouds with measurements. We show that optical phase curves can help constrain the composition and size of the cloud particles. Indeed, model fitting for Kepler-7b requires poorly absorbing particles that scatter with low-to-moderate anisotropic efficiency, conclusions consistent with condensates of silicates, perovskite, and silica of submicron radii. We also show that we are limited in our ability to pin down the extent and location of the clouds. These considerations are relevant to the interpretation of optical phase curves with general circulation models. Finally, we estimate that the spherical albedo of Kepler-7b over the Kepler passband is in the range 0.4-0.5.

  11. Soil Water Retention Curve

    Science.gov (United States)

    Johnson, L. E.; Kim, J.; Cifelli, R.; Chandra, C. V.

    2016-12-01

    Potential water retention, S, is one of parameters commonly used in hydrologic modeling for soil moisture accounting. Physically, S indicates total amount of water which can be stored in soil and is expressed in units of depth. S can be represented as a change of soil moisture content and in this context is commonly used to estimate direct runoff, especially in the Soil Conservation Service (SCS) curve number (CN) method. Generally, the lumped and the distributed hydrologic models can easily use the SCS-CN method to estimate direct runoff. Changes in potential water retention have been used in previous SCS-CN studies; however, these studies have focused on long-term hydrologic simulations where S is allowed to vary at the daily time scale. While useful for hydrologic events that span multiple days, the resolution is too coarse for short-term applications such as flash flood events where S may not recover its full potential. In this study, a new method for estimating a time-variable potential water retention at hourly time-scales is presented. The methodology is applied for the Napa River basin, California. The streamflow gage at St Helena, located in the upper reaches of the basin, is used as the control gage site to evaluate the model performance as it is has minimal influences by reservoirs and diversions. Rainfall events from 2011 to 2012 are used for estimating the event-based SCS CN to transfer to S. As a result, we have derived the potential water retention curve and it is classified into three sections depending on the relative change in S. The first is a negative slope section arising from the difference in the rate of moving water through the soil column, the second is a zero change section representing the initial recovery the potential water retention, and the third is a positive change section representing the full recovery of the potential water retention. Also, we found that the soil water moving has traffic jam within 24 hours after finished first

  12. CONSTRUCTION OF G2 CONTINUOUS CURVES ON SURFACE WITH PLANAR CUBIC B(E)ZIER CURVES

    Institute of Scientific and Technical Information of China (English)

    Wang Xiaoping; Zhang Weizhong; Zhang Liyan; Zhou Rurong

    2005-01-01

    The problem of constructing curve on parametric surface (or surface that can be parameterized) such that it interpolates a sequence of points with prescribed tangent direction and curvature vector (or geodesic curvature) at every point and the issue of curve blending on this kind of surface are researched. The mapping and tangent mapping from the surface to its parametric plane are introduced and thus several conclusions with differential geometry are deduced. Based on those conclusions, the problem of interpolating (or blending) curve on a parametric surface is converted to a similar one on its parametric plane. The final solution curve of either interpolation or blending issue is explicit and can still be expressed by parametric form. And so, unlike existing methods, the presented method needs not to use any surface/surface intersection algorithms, usually a troublesome process, for displaying such interpolation curve. Experiment results show the presented methods are feasible and applicable to CAD/CAM and computer graphics.

  13. Geometric invariant theory for polarized curves

    CERN Document Server

    Bini, Gilberto; Melo, Margarida; Viviani, Filippo

    2014-01-01

    We investigate GIT quotients of polarized curves. More specifically, we study the GIT problem for the Hilbert and Chow schemes of curves of degree d and genus g in a projective space of dimension d-g, as d decreases with respect to g. We prove that the first three values of d at which the GIT quotients change are given by d=a(2g-2) where a=2, 3.5, 4. We show that, for a>4, L. Caporaso's results hold true for both Hilbert and Chow semistability. If 3.5curves. If 2curves. We also analyze in detail the critical values a=3.5 and a=4, where the Hilbert semistable locus is strictly smaller than the Chow semistable locus. As an application, we obtain three compactications of the universal Jacobian over the moduli space of stable curves, weakly-pseudo-stable curves and pseu...

  14. Comparative power curves in bird flight.

    Science.gov (United States)

    Tobalske, B W; Hedrick, T L; Dial, K P; Biewener, A A

    2003-01-23

    The relationship between mechanical power output and forward velocity in bird flight is controversial, bearing on the comparative physiology and ecology of locomotion. Applied to flying birds, aerodynamic theory predicts that mechanical power should vary as a function of forward velocity in a U-shaped curve. The only empirical test of this theory, using the black-billed magpie (Pica pica), suggests that the mechanical power curve is relatively flat over intermediate velocities. Here, by integrating in vivo measurements of pectoralis force and length change with quasi-steady aerodynamic models developed using data on wing and body movement, we present mechanical power curves for cockatiels (Nymphicus hollandicus) and ringed turtle-doves (Streptopelia risoria). In contrast to the curve reported for magpies, the power curve for cockatiels is acutely concave, whereas that for doves is intermediate in shape and shows higher mass-specific power output at most speeds. We also find that wing-beat frequency and mechanical power output do not necessarily share minima in flying birds. Thus, aspects of morphology, wing kinematics and overall style of flight can greatly affect the magnitude and shape of a species' power curve.

  15. Curved-Region-Based Ridge Frequency Estimation and Curved Gabor Filters for Fingerprint Image Enhancement

    Science.gov (United States)

    Gottschlich, Carsten

    2012-04-01

    Gabor filters play an important role in many application areas for the enhancement of various types of images and the extraction of Gabor features. For the purpose of enhancing curved structures in noisy images, we introduce curved Gabor filters which locally adapt their shape to the direction of flow. These curved Gabor filters enable the choice of filter parameters which increase the smoothing power without creating artifacts in the enhanced image. In this paper, curved Gabor filters are applied to the curved ridge and valley structure of low-quality fingerprint images. First, we combine two orientation field estimation methods in order to obtain a more robust estimation for very noisy images. Next, curved regions are constructed by following the respective local orientation and they are used for estimating the local ridge frequency. Lastly, curved Gabor filters are defined based on curved regions and they are applied for the enhancement of low-quality fingerprint images. Experimental results on the FVC2004 databases show improvements of this approach in comparison to state-of-the-art enhancement methods.

  16. Cubic B-spline curve approximation by curve unclamping

    OpenAIRE

    Chen, Xiao-Diao; Ma, Weiyin; Paul, Jean-Claude

    2010-01-01

    International audience; A new approach for cubic B-spline curve approximation is presented. The method produces an approximation cubic B-spline curve tangent to a given curve at a set of selected positions, called tangent points, in a piecewise manner starting from a seed segment. A heuristic method is provided to select the tangent points. The first segment of the approximation cubic B-spline curve can be obtained using an inner point interpolation method, least-squares method or geometric H...

  17. Gelfond–Bézier curves

    KAUST Repository

    Ait-Haddou, Rachid

    2013-02-01

    We show that the generalized Bernstein bases in Müntz spaces defined by Hirschman and Widder (1949) and extended by Gelfond (1950) can be obtained as pointwise limits of the Chebyshev–Bernstein bases in Müntz spaces with respect to an interval [a,1][a,1] as the positive real number a converges to zero. Such a realization allows for concepts of curve design such as de Casteljau algorithm, blossom, dimension elevation to be transferred from the general theory of Chebyshev blossoms in Müntz spaces to these generalized Bernstein bases that we termed here as Gelfond–Bernstein bases. The advantage of working with Gelfond–Bernstein bases lies in the simplicity of the obtained concepts and algorithms as compared to their Chebyshev–Bernstein bases counterparts.

  18. Correlation of pool boiling curves for the homogeous group freons

    Energy Technology Data Exchange (ETDEWEB)

    Westwater, J.W. (Dept. of Chemical Engineering, Univ. of Illnois, Urban, IL (US)); Zinn, J.C. (Monsanto, Co., St. Louis, MO (US)); Brodbeck, K.J. (Clorox Corp., Pleasanton, CA (US))

    1989-02-01

    A knowledge of the complete boiling curve q verses {Delta}T for a liquid, including the regimes of nucleate boiling, transition boiling, and a film boiling is needed for the design and operation of various types of heat transfer equipment. No general method exists for predicting the complete curve. Most difficult is the prediction of the nucleate boiling curve, the transition curve, and the temperature that separates the two. If the curve for every liquid at every pressure must be determined experimentally, we are faced with a formidable task. This paper shows that some simplification is possible for members of a homologous group.

  19. Is the tautochrone curve unique?

    Science.gov (United States)

    Terra, Pedro; de Melo e Souza, Reinaldo; Farina, C.

    2016-12-01

    We show that there are an infinite number of tautochrone curves in addition to the cycloid solution first obtained by Christiaan Huygens in 1658. We begin by reviewing the inverse problem of finding the possible potential energy functions that lead to periodic motions of a particle whose period is a given function of its mechanical energy. There are infinitely many such solutions, called "sheared" potentials. As an interesting example, we show that a Pöschl-Teller potential and the one-dimensional Morse potentials are sheared relative to one another for negative energies, clarifying why they share the same oscillation periods for their bounded solutions. We then consider periodic motions of a particle sliding without friction over a track around its minimum under the influence of a constant gravitational field. After a brief historical survey of the tautochrone problem we show that, given the oscillation period, there is an infinity of tracks that lead to the same period. As a bonus, we show that there are infinitely many tautochrones.

  20. Reflection of curved shock waves

    Science.gov (United States)

    Mölder, S.

    2017-03-01

    Shock curvatures are related to pressure gradients, streamline curvatures and vorticity in flows with planar and axial symmetry. Explicit expressions, in an influence coefficient format, are used to relate post-shock pressure gradient, streamline curvature and vorticity to pre-shock gradients and shock curvature in steady flow. Using higher order, von Neumann-type, compatibility conditions, curved shock theory is applied to calculate the flow near singly and doubly curved shocks on curved surfaces, in regular shock reflection and in Mach reflection. Theoretical curved shock shapes are in good agreement with computational fluid dynamics calculations and experiment.

  1. Reflection of curved shock waves

    Science.gov (United States)

    Mölder, S.

    2017-09-01

    Shock curvatures are related to pressure gradients, streamline curvatures and vorticity in flows with planar and axial symmetry. Explicit expressions, in an influence coefficient format, are used to relate post-shock pressure gradient, streamline curvature and vorticity to pre-shock gradients and shock curvature in steady flow. Using higher order, von Neumann-type, compatibility conditions, curved shock theory is applied to calculate the flow near singly and doubly curved shocks on curved surfaces, in regular shock reflection and in Mach reflection. Theoretical curved shock shapes are in good agreement with computational fluid dynamics calculations and experiment.

  2. Heegner modules and elliptic curves

    CERN Document Server

    Brown, Martin L

    2004-01-01

    Heegner points on both modular curves and elliptic curves over global fields of any characteristic form the topic of this research monograph. The Heegner module of an elliptic curve is an original concept introduced in this text. The computation of the cohomology of the Heegner module is the main technical result and is applied to prove the Tate conjecture for a class of elliptic surfaces over finite fields; this conjecture is equivalent to the Birch and Swinnerton-Dyer conjecture for the corresponding elliptic curves over global fields.

  3. Closed planar curves without inflections

    CERN Document Server

    Ohno, Shuntaro; Umehara, Masaaki

    2011-01-01

    We define a computable topological invariant $\\mu(\\gamma)$ for generic closed planar regular curves $\\gamma$, which gives an effective lower bound for the number of inflection points on a given generic closed planar curve. Using it, we classify the topological types of locally convex curves (i.e. closed planar regular curves without inflections) whose numbers of crossings are less than or equal to five. Moreover, we discuss the relationship between the number of double tangents and the invariant $\\mu(\\gamma)$ on a given $\\gamma$.

  4. Probing exoplanet clouds with optical phase curves

    CERN Document Server

    Munoz, A Garcia

    2015-01-01

    Kepler-7b is to date the only exoplanet for which clouds have been inferred from the optical phase curve -- from visible-wavelength whole-disk brightness measurements as a function of orbital phase. Added to this, the fact that the phase curve appears dominated by reflected starlight makes this close-in giant planet a unique study case. Here we investigate the information on coverage and optical properties of the planet clouds contained in the measured phase curve. We generate cloud maps of Kepler-7b and use a multiple-scattering approach to create synthetic phase curves, thus connecting postulated clouds with measurements. We show that optical phase curves can help constrain the composition and size of the cloud particles. Indeed, model fitting for Kepler-7b requires poorly absorbing particles that scatter with low-to-moderate anisotropic efficiency, conclusions consistent with condensates of silicates, perovskite, and silica of submicron radii. We also show that we are limited in our ability to pin down the...

  5. The Health Show

    OpenAIRE

    Swann, David

    2011-01-01

    Dr David Swann interviewed on The Health Show, Series 1, Episode 5, 2011 for BBC World about the award-winning 21st Century Nursing Bag. BBC World News reaches 241million people every week, available in 296 million homes, 1.8 million hotel rooms and has the highest average viewership on a weekday of any international news channel. The Health Show is a new 26-part series for BBC World News covering the most important news stories from around the world.

  6. Is the tautochrone curve unique?

    CERN Document Server

    Terra, Pedro; Farina, C

    2016-01-01

    The answer to this question is no. In fact, in addition to the solution first obtained by Christiaan Huygens in 1658, given by the cycloid, we show that there is an infinite number of tautochrone curves. With this goal, we start by briefly reviewing an the problem of finding out the possible potential energies that lead to periodic motions of a particle whose period is a given function of its mechanical energy. There are infinitely many solutions, called sheared potentials. As an interesting example, we show that a P\\"oschl-Teller and the one-dimensional Morse potentials are sheared relative to one another for negative energies, clarifying why they share the same periods of oscillations for their bounded solutions. We then consider periodic motions of a particle sliding without friction over a track around its minimum under the influence of an uniform gravitational field. After a brief historical survey of the tautochrone problem we show that, given the period of oscillations, there is an infinity of tracks w...

  7. Cobalt plaque versus enucleation for uveal melanoma: comparison of survival rates.

    OpenAIRE

    Adams, K S; Abramson, D. H.; Ellsworth, R M; Haik, B G; Bedford, M; Packer, S; Seddon, J; Albert, D.; Polivogianis, L

    1988-01-01

    Two hundred and twenty-three patients treated by cobalt plaque for uveal melanoma were compared with 416 patients treated by enucleation for uveal melanoma in terms of patient survival. The median follow-up time for the patients treated by cobalt plaque was 4.3 years. Kaplan-Meier survival curves were calculated up to five years following treatment based on time to tumour-related deaths. Cox's proportional hazards multivariate analysis was performed to determine which variables were related t...

  8. Effects of Smoking on Menopausal Age: Results From the Korea National Health and Nutrition Examination Survey, 2007 to 2012

    OpenAIRE

    Yang, Hee Jung; Suh, Pae Sun; Kim, Soo Jeong; Lee, Soon Young

    2015-01-01

    Objectives: Decreased fertility and impaired health owing to early menopause are significant health issues. Smoking is a modifiable health-related behavior that influences menopausal age. We investigated the effects of smoking-associated characteristics on menopausal age in Korean women. Methods: This study used data from the Korea National Health and Nutrition Examination Survey from 2007 to 2012. Menopausal age in relation to smoking was analyzed as a Kaplan-Meier survival curve for 11 510 ...

  9. A Fashion Show

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    <正>Story: The yearly fashion show day.The children take turns to walk on the stage and show the class their favorite clothes.Now it’s Joe’s and Phoebe’s turn.Joe walks on the stage and says,“My shorts are blue.Do you like my blue shorts?”On the other side of the stage, Phoebe is wearing her favorite pink skirt.“My skirt is pink.Do you like my pink skirt?”asks

  10. Behavior of horizontally curved steel tubular-flange bridge girders

    Science.gov (United States)

    Fan, Zhuo

    A new type of curved steel bridge girder, called a curved tubular-flange girder, with rectangular tubes as flanges, is proposed and studied in this dissertation. A curved steel tubular-flange girder has much larger torsional stiffness than a curved I-girder and less potential for cross section distortion than a curved box-girder. Therefore, it has potential advantages compared to curved I-girders and box-girders. A theoretical analysis method for systems of curved tubular-flange girders braced by cross frames is presented. A stress analysis method for tubular-flange girders is also provided. The behavior of curved tubular-flange girder systems is studied using the theoretical analysis method and compared to the behavior of the corresponding curved I-girder systems. A parametric study is performed using the theoretical analysis method to investigate the effects of geometric parameters on the behavior of curved tubular-flange girder systems. The studied parameters include tubular-flange width, tubular-flange depth, cross section depth, girder curvature, and the number of cross frames. Finite element analyses are conducted to verify the theoretical analysis method, to study the behavior of a curved tubular-flange girder system under dead load, and to study the behavior of a curved tubular-flange girder system with a composite concrete deck under dead and live load. The study shows that a curved tubular-flange girder system develops much less warping normal stress and cross section rotation than a corresponding curved I-girder system. The difference is especially significant for a single curved girder under its own weight, suggesting that curved tubular-flange girders would be much easier to transport and erect than curved I-girders. As girder curvature increases, the rate of increase in the stresses and displacements for a single I-girder is much greater than for a single curved tubular-flange girder. Smaller cross frame forces develop in a tubular-flange girder

  11. Picard groups of differential operators on curves

    CERN Document Server

    Wilson, George

    2010-01-01

    Let X be a complex affine curve (not isomorphic to the affine line), and let Pic(D) be the group of autoequivalences of the category of D(X)-modules. Cannings and Holland have shown that Pic(D) fits into an exact sequence in which the other groups can be considered known: we show that this sequence is split.

  12. Migration and the Wage Curve:

    DEFF Research Database (Denmark)

    Brücker, Herbert; Jahn, Elke J.

      Based on a wage curve approach we examine the labor market effects of migration in Germany. The wage curve relies on the assumption that wages respond to a change in the unemployment rate, albeit imperfectly. This allows one to derive the wage and employment effects of migration simultaneously...

  13. On not showing scalps

    DEFF Research Database (Denmark)

    Marselis, Randi Lorenz

    2016-01-01

    proposed by Janet Marstine, the editor of the Routledge Companion to Museum Ethics, I show how the museum succeeded in engaging users in questions of museum ethics. However, this specific debate on human remains in museums developed into an encounter between a global, museological discourse...

  14. Violence and TV Shows

    OpenAIRE

    ÖZTÜRK, Yrd. Doç. Dr. Şinasi

    2008-01-01

    This study aims to discuss theories on theviolent effects of TV shows on viewers, especiallyon children. Therefore, this study includes a briefdiscussion of definitions of violence, discussionof violence theories, main results of researcheson televised violence, measuring TV violence,perception of televised violence, individualdifferences and reactions to TV violence,aggressiveness and preferences for TV violence.

  15. Honored Teacher Shows Commitment.

    Science.gov (United States)

    Ratte, Kathy

    1987-01-01

    Part of the acceptance speech of the 1985 National Council for the Social Studies Teacher of the Year, this article describes the censorship experience of this honored social studies teacher. The incident involved the showing of a videotape version of the feature film entitled "The Seduction of Joe Tynan." (JDH)

  16. A Visionary Show

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    Seduction. Distinction. Relax. Pulsation. These are the "style universes" on display at Première Vision, heralded as "The World’s Premiere Fabric Show." Started more than 35 years ago by 15 French weavers, Première Vision has expanded beyond its

  17. Honored Teacher Shows Commitment.

    Science.gov (United States)

    Ratte, Kathy

    1987-01-01

    Part of the acceptance speech of the 1985 National Council for the Social Studies Teacher of the Year, this article describes the censorship experience of this honored social studies teacher. The incident involved the showing of a videotape version of the feature film entitled "The Seduction of Joe Tynan." (JDH)

  18. Timelike curves can increase entanglement with LOCC

    Science.gov (United States)

    Moulick, Subhayan Roy; Panigrahi, Prasanta K.

    2016-11-01

    We study the nature of entanglement in presence of Deutschian closed timelike curves (D-CTCs) and open timelike curves (OTCs) and find that existence of such physical systems in nature would allow us to increase entanglement using local operations and classical communication (LOCC). This is otherwise in direct contradiction with the fundamental definition of entanglement. We study this problem from the perspective of Bell state discrimination, and show how D-CTCs and OTCs can unambiguously distinguish between four Bell states with LOCC, that is otherwise known to be impossible.

  19. Direct stigmatic imaging with curved surfaces.

    Science.gov (United States)

    Courtial, Johannes; Oxburgh, Stephen; Tyc, Tomáš

    2015-03-01

    We study the possibilities of direct (using one intersection with each light ray) stigmatic imaging with a curved surface that can change ray directions in an arbitrary way. By purely geometric arguments we show that the only possible case of such imaging is the trivial one where the image of any point is identical to the point itself and the surface does not perform any change of the ray direction at all. We also discuss an example of a curved surface which performs indirect stigmatic imaging after twice intersecting each light ray.

  20. On Clifford's theorem for singular curves

    CERN Document Server

    Franciosi, Marco

    2011-01-01

    Let C be a 2-connected Gorenstein curve either reduced or contained in a smooth algebraic surface and let S be a subcanonical cluster (i.e. a 0-dim scheme such that the space H^0(C, I_S K_C) contains a generically invertible section). Under some general assumptions on S or C we show that h^0(C, I_S K_C) <= p_a(C) - deg (S)/2 and if equality holds then either S is trivial, or C is honestly hyperelliptic or 3-disconnected. As a corollary we give a generalization of Clifford's theorem for reduced curves.

  1. Topological Field Theory and Rational Curves

    CERN Document Server

    Aspinwall, Paul S; Aspinwall, Paul S.; Morrison, David R.

    1993-01-01

    We analyze the superstring propagating on a Calabi-Yau threefold. This theory naturally leads to the consideration of Witten's topological non-linear sigma-model and the structure of rational curves on the Calabi-Yau manifold. We study in detail the case of the world-sheet of the string being mapped to a multiple cover of an isolated rational curve and we show that a natural compactification of the moduli space of such a multiple cover leads to a formula in agreement with a conjecture by Candelas, de la Ossa, Green and Parkes.

  2. Curve-centric volume reformation for comparative visualization.

    Science.gov (United States)

    Daae Lampe, Ove; Correa, Carlos; Ma, Kwan-Liu; Hauser, Helwig

    2009-01-01

    We present two visualization techniques for curve-centric volume reformation with the aim to create compelling comparative visualizations. A curve-centric volume reformation deforms a volume, with regards to a curve in space, to create a new space in which the curve evaluates to zero in two dimensions and spans its arc-length in the third. The volume surrounding the curve is deformed such that spatial neighborhood to the curve is preserved. The result of the curve-centric reformation produces images where one axis is aligned to arc-length, and thus allows researchers and practitioners to apply their arc-length parameterized data visualizations in parallel for comparison. Furthermore we show that when visualizing dense data, our technique provides an inside out projection, from the curve and out into the volume, which allows for inspection what is around the curve. Finally we demonstrate the usefulness of our techniques in the context of two application cases. We show that existing data visualizations of arc-length parameterized data can be enhanced by using our techniques, in addition to creating a new view and perspective on volumetric data around curves. Additionally we show how volumetric data can be brought into plotting environments that allow precise readouts. In the first case we inspect streamlines in a flow field around a car, and in the second we inspect seismic volumes and well logs from drilling.

  3. NURBS curve blending using extension

    Institute of Scientific and Technical Information of China (English)

    Yong-jin LIU; Rong-qi QIU; Xiao-hui LIANG

    2009-01-01

    Curve and surface blending is an important operation in CAD systems, in which a non-uniform rational B-spline (NURBS) has been used as the de facto standard. In local comer blending, two curves intersecting at that comer are first made disjoint, and then the third blending curve is added-in to smoothly join the two curves with G1-or G2-continuity. In this paper we present a study to solve the joint problem based on curve extension. The following nice properties of this extension algorithm are exploited in depth: (1) The parameterization of the original shapes does not change; (2) No additional fragments are created.Various examples are presented to demonstrate that our solution is simple and efficient.

  4. Three-Body Choreographies in Given Curves

    CERN Document Server

    Ozaki, Hiroshi; Fujiwara, Toshiaki

    2009-01-01

    As shown by Johannes Kepler in 1609, in the two-body problem, the shape of the orbit, a given ellipse, and a given non-vanishing constant angular momentum determines the motion of the planet completely. Even in the three-body problem, in some cases, the shape of the orbit, conservation of the centre of mass and a constant of motion (the angular momentum or the total energy) determines the motion of the three bodies. We show, by a geometrical method, that choreographic motions, in which equal mass three bodies chase each other around a same curve, will be uniquely determined for the following two cases. (i) Convex curves that have point symmetry and non-vanishing angular momentum are given. (ii) Eight-shaped curves which are similar to the curve for the figure-eight solution and the energy constant are given. The reality of the motion should be tested whether the motion satisfies an equation of motion or not. Extensions of the method for generic curves are shown. The extended methods are applicable to generic ...

  5. Cylindrical Helix Spline Approximation of Spatial Curves

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    In this paper, we present a new method for approximating spatial curves with a G1 cylindrical helix spline within a prescribed tolerance. We deduce the general formulation of a cylindrical helix,which has 11 freedoms. This means that it needs 11 restrictions to determine a cylindrical helix. Given a spatial parametric curve segment, including the start point and the end point of this segment, the tangent and the principal normal of the start point, we can always find a cylindrical segment to interpolate the given direction and position vectors. In order to approximate the known parametric curve within the prescribed tolerance, we adopt the trial method step by step. First, we must ensure the helix segment to interpolate the given two end points and match the principal normal and tangent of the start point, and then, we can keep the deviation between the cylindrical helix segment and the known curve segment within the prescribed tolerance everywhere. After the first segment had been formed, we can construct the next segment. Circularly, we can construct the G1 cylindrical helix spline to approximate the whole spatial parametric curve within the prescribed tolerance. Several examples are also given to show the efficiency of this method.

  6. Curved Nanotube Structures under Mechanical Loading

    Directory of Open Access Journals (Sweden)

    Hamidreza Yazdani Sarvestani

    2015-01-01

    Full Text Available Configuration of carbon nanotube (CNT has been the subject of research to perform theoretical development for analyzing nanocomposites. A new theoretical solution is developed to study curved nanotube structures subjected to mechanical loadings. A curved nanotube structure is considered. A nonlocal displacement-based solution is proposed by using a displacement approach of Toroidal Elasticity based on Eringen’s theory of nonlocal continuum mechanics. The governing equations of curved nanotube structures are developed in toroidal coordinate system. The method of successive approximation is used to discretize the displacement-based governing equations and find the general solution subjected to bending moment. The numerical results show that all displacement components increase with increasing the nonlocal parameter. The present theoretical study highlights the significance of the geometry and nonlocal parameter effects on mechanical behavior of nanotube structures.

  7. Asymmetry Dependence of the Nuclear Caloric Curve

    CERN Document Server

    McIntosh, Alan B; Cammarata, Paul; Hagel, Kris; Heilborn, Lauren; Kohley, Zachary; Mabiala, Justin; May, Larry W; Marini, Paola; Raphelt, Andrew; Souliotis, George A; Wuenschel, Sara; Zarrella, Andrew; Yennello, Sherry J

    2012-01-01

    A basic feature of the nuclear equation of state is not yet understood: the dependence of the nuclear caloric curve on the neutron-proton asymmetry. Predictions of theoretical models differ on the magnitude and even the sign of this dependence. In this work, the nuclear caloric curve is examined for fully reconstructed quasi-projectiles around mass A=50. The caloric curve extracted with the momentum quadrupole fluctuation thermometer shows that the temperature varies linearly with quasi-projectile asymmetry (N-Z)/A. An increase in asymmetry of 0.15 units corresponds to a decrease in temperature on the order of 1 MeV. These results also highlight the importance of a full quasi-projectile reconstruction in the study of thermodynamic properties of hot nuclei.

  8. The genus curve of the Abell clusters

    Science.gov (United States)

    Rhoads, James E.; Gott, J. Richard, III; Postman, Marc

    1994-01-01

    We study the topology of large-scale structure through a genus curve measurement of the recent Abell catalog redshift survey of Postman, Huchra, and Geller (1992). The structure is found to be spongelike near median density and to exhibit isolated superclusters and voids at high and low densities, respectively. The genus curve shows a slight shift toward 'meatball' topology, but remains consistent with the hypothesis of Gaussian random phase initial conditions. The amplitude of the genus curve corresponds to a power-law spectrum with index n = 0.21(sub -0.47 sup +0.43) on scales of 48/h Mpc or to a cold dark matter power spectrum with omega h = 0.36(sub -0.17 sup +0.46).

  9. Shanghai Shows Its Heart

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    The city known as China’s economic powerhouse showed a more caring face as host of the Special Olympic Games Between October 2 and 11,the Special Olympics Summer Games were hosted in Shanghai,the first time the 40-year-old athletic com- petition for people with intellectual disabilities came to a developing country. This Special Olympics was also larger than all previous games in temps of the number of athletes.

  10. The approximation of generalized Log-aesthetic curves using Quintic Bezier curves

    Science.gov (United States)

    Albayari, Diya’ J.; Gobithaasan, R. U.; Miura, Kenjiro T.

    2017-09-01

    Generalized Log Aesthetic Curve segments (GLAC) are aesthetic curves that have monotonic curvature profile and hence they are considered fair. In the field of Computer-Aided Design (CAD), there exists a demand to construct fair curves for various design intent. However, we cannot implement GLAC in CAD system partly due to its transcendental form. A viable solution is to approximate GLACs using a quintic polynomial curve in the form of Bezier using curvature error measure. The problem of this approach is that it requires a formidable size of computations due to arc length reparametrization. In this paper, we introduce a new method of calculating curvature error measure using natural spline interpolation function to minimize computation effort while preserving the accuracy. The final section shows numerical examples depicting the proposed approximation of two types of the GLAC, which clearly indicate the efficiency of proposed method.

  11. RESEARCH ON A MORE RATIONAL CONFIGURATION OF THE INVERT CURVE OF A SPILLWAY

    Institute of Scientific and Technical Information of China (English)

    Liu Yu-ling; Wei Wen-li; Shen Yong-ming

    2003-01-01

    This paper is concerned with the research on the rational curve for the bucket of a spillway. A new type of rational curve against cavitation damage to spillway has been proposed; and the numerical results show that the proposed curve (gradually and continuously varied curvature curve, abbreviated as GCVC curve) can greatly raise the minimum cavitation number and cause the distribution of water pressure on the curved surface more reasonable. The proposed curve (GCVC curve) is simple, and can be conveniently used in practical hydraulic engineering.

  12. Not a "reality" show.

    Science.gov (United States)

    Wrong, Terence; Baumgart, Erica

    2013-01-01

    The authors of the preceding articles raise legitimate questions about patient and staff rights and the unintended consequences of allowing ABC News to film inside teaching hospitals. We explain why we regard their fears as baseless and not supported by what we heard from individuals portrayed in the filming, our decade-long experience making medical documentaries, and the full un-aired context of the scenes shown in the broadcast. The authors don't and can't know what conversations we had, what documents we reviewed, and what protections we put in place in each televised scene. Finally, we hope to correct several misleading examples cited by the authors as well as their offhand mischaracterization of our program as a "reality" show.

  13. Equations of hyperelliptic Shimura curves

    CERN Document Server

    Molina, Santiago

    2010-01-01

    We describe an algorithm that computes explicit models of hyperelliptic Shimura curves attached to an indefnite quaternion algebra over Q and Atkin-Lehner quotients of them. It exploits Cerednik-Drinfeld's non-archimedean uniformisation of Shimura curves, a formula of Gross and Zagier for the endomorphism ring of Heegner points over Artinian rings and the connection between Ribet's bimodules and the specialization of Heegner points. As an application, we provide a list of equations of Shimura curves and quotients of them obtained by our algorithm that had been conjectured by Kurihara.

  14. Poiseuille flow in curved spaces

    CERN Document Server

    Debus, J -D; Succi, S; Herrmann, H J

    2015-01-01

    We investigate Poiseuille channel flow through intrinsically curved (campylotic) media, equipped with localized metric perturbations (campylons). To this end, we study the flux of a fluid driven through the curved channel in dependence of the spatial deformation, characterized by the campylon parameters (amplitude, range and density). We find that the flux depends only on a specific combination of campylon parameters, which we identify as the average campylon strength, and derive a universal flux law for the Poiseuille flow. For the purpose of this study, we have improved and validated our recently developed lattice Boltzmann model in curved space by considerably reducing discrete lattice effects.

  15. Showing Value (Editorial

    Directory of Open Access Journals (Sweden)

    Denise Koufogiannakis

    2009-06-01

    Full Text Available When Su Cleyle and I first decided to start Evidence Based Library and Information Practice, one of the things we agreed upon immediately was that the journal be open access. We knew that a major obstacle to librarians using the research literature was that they did not have access to the research literature. Although Su and I are both academic librarians who can access a wide variety of library and information literature from our institutions, we belong to a profession where not everyone has equal access to the research in our field. Without such access to our own body of literature, how can we ever hope for practitioners to use research evidence in their decision making? It would have been contradictory to the principles of evidence based library and information practice to do otherwise.One of the specific groups we thought could use such an open access venue for discovering research literature was school librarians. School librarians are often isolated and lacking access to the research literature that may help them prove to stakeholders the importance of their libraries and their role within schools. Certainly, school libraries have been in decline and the use of evidence to show value is needed. As Ken Haycock noted in his 2003 report, The Crisis in Canada’s School Libraries: The Case for Reform and Reinvestment, “Across the country, teacher-librarians are losing their jobs or being reassigned. Collections are becoming depleted owing to budget cuts. Some principals believe that in the age of the Internet and the classroom workstation, the school library is an artifact” (9. Within this context, school librarians are looking to our research literature for evidence of the impact that school library programs have on learning outcomes and student success. They are integrating that evidence into their practice, and reflecting upon what can be improved locally. They are focusing on students and showing the impact of school libraries and

  16. Public medical shows.

    Science.gov (United States)

    Walusinski, Olivier

    2014-01-01

    In the second half of the 19th century, Jean-Martin Charcot (1825-1893) became famous for the quality of his teaching and his innovative neurological discoveries, bringing many French and foreign students to Paris. A hunger for recognition, together with progressive and anticlerical ideals, led Charcot to invite writers, journalists, and politicians to his lessons, during which he presented the results of his work on hysteria. These events became public performances, for which physicians and patients were transformed into actors. Major newspapers ran accounts of these consultations, more like theatrical shows in some respects. The resultant enthusiasm prompted other physicians in Paris and throughout France to try and imitate them. We will compare the form and substance of Charcot's lessons with those given by Jules-Bernard Luys (1828-1897), Victor Dumontpallier (1826-1899), Ambroise-Auguste Liébault (1823-1904), Hippolyte Bernheim (1840-1919), Joseph Grasset (1849-1918), and Albert Pitres (1848-1928). We will also note their impact on contemporary cinema and theatre.

  17. More Unusual Light Curves from Kepler

    Science.gov (United States)

    Kohler, Susanna

    2017-03-01

    Twenty-three new objects have been added to the growing collection of stars observed to have unusual dips in their light curves. A recent study examines these stars and the potential causes of their strange behavior.An Influx of DataThe primary Kepler mission provided light curves for over 100,000 stars, and its continuation K2 is observing another 20,000 stars every three months. As we enter an era where these enormous photometric data sets become commonplace Gaia will obtain photometry for millions of stars, and LSST billions its crucial that we understand the different categories of variability observed in these stars.The authors find three different types of light curves among their 23 unusual stars. Scallop-shell curves (top) show many undulations; persistent flux-dip class curves (middle) have discrete triangularly shaped flux dips; transient, narrow dip class curves (bottom) have only one dip that is variable in depth. The authors speculate a common cause for the scallop-shell and persistent flux-dip stars, and a different cause for the transient flux-dip stars. [Stauffer et al. 2017]After filtering out the stars with planets, those in binary systems, those with circumstellar disks, and those with starspots, a number of oddities remain: a menagerie of stars with periodic variability that cant be accounted for in these categories. Some of these stars are now famous (for instance, Boyajians star); some are lesser known. But by continuing to build up this sample of stars with unusual light curves, we have a better chance of understanding the sources of variability.Building the MenagerieTo this end, a team of scientists led by John Stauffer (Spitzer Science Center at Caltech) has recently hunted for more additions to this sample in the K2 data set. In particular, they searched through the light curves from stars in the Oph and Upper Scorpius star-forming region a data set that makes up the largest collection of high-quality light curves for low-mass, pre

  18. Null surfaces of null curves on 3-null cone

    Science.gov (United States)

    Sun, Jianguo; Pei, Donghe

    2014-03-01

    The null surfaces of null curves on 3-null cone have the applications in the studying of horizon types. Via the pseudo-scalar product and Frenet equations, the differential geometry of null curves on 3-null cone is obtained. In the local sense, the curvature describes the contact of submanifolds with pseudo-spheres. We introduce the geometric properties of the curvatures and show the singularities of null surfaces, which are constructed over the null curves.

  19. Integrable Flows for Starlike Curves in Centroaffine Space

    Directory of Open Access Journals (Sweden)

    Annalisa Calini

    2013-03-01

    Full Text Available We construct integrable hierarchies of flows for curves in centroaffine R^3 through a natural pre-symplectic structure on the space of closed unparametrized starlike curves. We show that the induced evolution equations for the differential invariants are closely connected with the Boussinesq hierarchy, and prove that the restricted hierarchy of flows on curves that project to conics in RP^2 induces the Kaup-Kuperschmidt hierarchy at the curvature level.

  20. The Great Cometary Show

    Science.gov (United States)

    2007-01-01

    its high spatial and spectral resolution, it was possible to zoom into the very heart of this very massive star. In this innermost region, the observations are dominated by the extremely dense stellar wind that totally obscures the underlying central star. The AMBER observations show that this dense stellar wind is not spherically symmetric, but exhibits a clearly elongated structure. Overall, the AMBER observations confirm that the extremely high mass loss of Eta Carinae's massive central star is non-spherical and much stronger along the poles than in the equatorial plane. This is in agreement with theoretical models that predict such an enhanced polar mass-loss in the case of rapidly rotating stars. ESO PR Photo 06c/07 ESO PR Photo 06c/07 RS Ophiuchi in Outburst Several papers from this special feature focus on the later stages in a star's life. One looks at the binary system Gamma 2 Velorum, which contains the closest example of a star known as a Wolf-Rayet. A single AMBER observation allowed the astronomers to separate the spectra of the two components, offering new insights in the modeling of Wolf-Rayet stars, but made it also possible to measure the separation between the two stars. This led to a new determination of the distance of the system, showing that previous estimates were incorrect. The observations also revealed information on the region where the winds from the two stars collide. The famous binary system RS Ophiuchi, an example of a recurrent nova, was observed just 5 days after it was discovered to be in outburst on 12 February 2006, an event that has been expected for 21 years. AMBER was able to detect the extension of the expanding nova emission. These observations show a complex geometry and kinematics, far from the simple interpretation of a spherical fireball in extension. AMBER has detected a high velocity jet probably perpendicular to the orbital plane of the binary system, and allowed a precise and careful study of the wind and the shockwave

  1. Description of dose response curve

    OpenAIRE

    Al-Samarai, Firas

    2011-01-01

    The book included several methods to estimate LD50, in addition to explain how to use several programs to estimate LD50. Moreover the book illustrate the description of the dose response curves. Firas Al-Samarai

  2. Normal origamis of Mumford curves

    CERN Document Server

    Kremer, Karsten

    2010-01-01

    An origami (also known as square-tiled surface) is a Riemann surface covering a torus with at most one branch point. Lifting two generators of the fundamental group of the punctured torus decomposes the surface into finitely many unit squares. By varying the complex structure of the torus one obtains easily accessible examples of Teichm\\"uller curves in the moduli space of Riemann surfaces. The p-adic analogues of Riemann surfaces are Mumford curves. A p-adic origami is defined as a covering of Mumford curves with at most one branch point, where the bottom curve has genus one. A classification of all normal non-trivial p-adic origamis is presented and used to calculate some invariants. These can be used to describe p-adic origamis in terms of glueing squares.

  3. Modeling and Fitting Exoplanet Transit Light Curves

    Science.gov (United States)

    Millholland, Sarah; Ruch, G. T.

    2013-01-01

    We present a numerical model along with an original fitting routine for the analysis of transiting extra-solar planet light curves. Our light curve model is unique in several ways from other available transit models, such as the analytic eclipse formulae of Mandel & Agol (2002) and Giménez (2006), the modified Eclipsing Binary Orbit Program (EBOP) model implemented in Southworth’s JKTEBOP code (Popper & Etzel 1981; Southworth et al. 2004), or the transit model developed as a part of the EXOFAST fitting suite (Eastman et al. in prep.). Our model employs Keplerian orbital dynamics about the system’s center of mass to properly account for stellar wobble and orbital eccentricity, uses a unique analytic solution derived from Kepler’s Second Law to calculate the projected distance between the centers of the star and planet, and calculates the effect of limb darkening using a simple technique that is different from the commonly used eclipse formulae. We have also devised a unique Monte Carlo style optimization routine for fitting the light curve model to observed transits. We demonstrate that, while the effect of stellar wobble on transit light curves is generally small, it becomes significant as the planet to stellar mass ratio increases and the semi-major axes of the orbits decrease. We also illustrate the appreciable effects of orbital ellipticity on the light curve and the necessity of accounting for its impacts for accurate modeling. We show that our simple limb darkening calculations are as accurate as the analytic equations of Mandel & Agol (2002). Although our Monte Carlo fitting algorithm is not as mathematically rigorous as the Markov Chain Monte Carlo based algorithms most often used to determine exoplanetary system parameters, we show that it is straightforward and returns reliable results. Finally, we show that analyses performed with our model and optimization routine compare favorably with exoplanet characterizations published by groups such as the

  4. Flow over riblet curved surfaces

    Energy Technology Data Exchange (ETDEWEB)

    Loureiro, J B R; Freire, A P Silva, E-mail: atila@mecanica.ufrj.br [Mechanical Engineering Program, Federal University of Rio de Janeiro (COPPE/UFRJ), C.P. 68503, 21.941-972, Rio de Janeiro, RJ (Brazil)

    2011-12-22

    The present work studies the mechanics of turbulent drag reduction over curved surfaces by riblets. The effects of surface modification on flow separation over steep and smooth curved surfaces are investigated. Four types of two-dimensional surfaces are studied based on the morphometric parameters that describe the body of a blue whale. Local measurements of mean velocity and turbulence profiles are obtained through laser Doppler anemometry (LDA) and particle image velocimetry (PIV).

  5. Investigating the relationship between unsaturated hydraulic conductivity curve and confined compression curve

    Science.gov (United States)

    Bayat, Hossein; Sedaghat, Azadeh; Safari Sinegani, Ali Akbar; Gregory, Andrew S.

    2015-03-01

    This study was conducted to estimate the soil unsaturated hydraulic conductivity through the van Genuchten model using easy to measure soil properties by regression and artificial neural networks methods. In this study, 148 soil samples were taken from five provinces of Iran. Basic soil properties (clay, silt/sand and bulk density) and other soil properties were measured. Soil water retention curve was measured to obtain the unsaturated hydraulic conductivity curve using the van Genuchten-Mualem model. Confined compression curve was measured and the modified model of van Genuchten was fitted on its data. Two-thirds and one-third of the data were used for the training and testing steps, respectively. Confined compression curve parameters and other soil properties were used as predictors to estimate unsaturated hydraulic conductivity curve. Pedotransfer functions (PTFs) were developed in two separate parts: in 5 and 6 PTFs basic soil properties were or were not used as predictors, respectively. The artificial neural networks (ANNs) performed better than the regression methods. Among the ANN-developed PTFs which have not used basic soil properties as predictors, PTFa3, with the inputs of the parameters of confined compression curve (n∗, α∗ and e0), performed better than the others. Also, among the ANN-developed PTFs that used basic soil properties as predictors along with the other input variables, PTFb5 that used the σmc (stress at the maximum curvature) and σi (stress at the inflection point) as inputs along with basic soil properties, performed better than the other PTFs. The results showed a successful prediction of the hydraulic conductivity curve using confined compression curve.

  6. CBS - A program for close binary system light curve analysis

    Science.gov (United States)

    Solmi, L.; Galli, M.

    CBS is a new program for binary system light curve analysis, it generates synthetic light curves for a binary system, accounting for eclipses, tidal distortion, limb darkening, gravity darkening and reflection; it is also possible to compute the light contribution and eclipses of an accretion disk. The bolometric light curve is generated, as well as curves for the U,B,V,R,I colour bands. In the following we give a brief description of the first version of the program and show some preliminary results.

  7. Planar-busting Curves on the Boundary of a Handlebody

    Institute of Scientific and Technical Information of China (English)

    Sun Dong-qi; Tang Jing-yan; Li Feng-ling

    2013-01-01

    Let Hn be an orientable handlebody of genus n. It has been proved that for n not less than 2, there exists an annulus-busting curve in ∂Hn. In the present paper, we prove that for n not less than 2, there exists an essential simple closed curve C in ∂Hn which intersects each essential planar surface in Hn non-emptily. Furthermore, we show that for n not less than 3, a pants-busting curve must also be an annulus-busting curve.

  8. Parametrization of $\\epsilon$-rational curves: error analysis

    CERN Document Server

    Rueda, Sonia L

    2010-01-01

    In [Computer Aided Geometric Design 27 (2010), 212-231] the authors present an algorithm to parametrize approximately $\\epsilon$-rational curves, and they show in 2 examples that the Hausdorff distance, w.r.t. to the Euclidean distance, between the input and output curves is small. In this paper, we analyze this distance for a whole family of curves randomly generated and we automatize the strategy used in [Computer Aided Geometric Design 27 (2010), 212-231]. We find a reasonable upper bound of the Hausdorff distance between each input and output curve of the family.

  9. Estimation of the Bezout number for piecewise algebraic curve

    Institute of Scientific and Technical Information of China (English)

    WANG; Renhong(王仁宏); XU; Zhiqiang(许志强)

    2003-01-01

    A piecewise algebraic curve is a curve determined by the zero set of a bivariate spline function.In this paper, a conjecture on triangulation is confirmed. The relation between the piecewise linear algebraiccurve and four-color conjecture is also presented. By Morgan-Scott triangulation, we will show the instabilityof Bezout number of piecewise algebraic curves. By using the combinatorial optimization method, an upperbound of the Bezout number defined as the maximum finite number of intersection points of two piecewisealgebraic curves is presented.

  10. Suitable Conditions of Reservoir Simulation for Searching Rule Curves

    Science.gov (United States)

    Kangrang, Anongrit; Chaleeraktrakoon, Chavalit

    The objective of this study is to carry out a suitable length of inflow record using in the simulation model. The second objective is to find an effect of initial reservoir capacity of reservoir simulation for searching the optimal rule curves. The reservoir simulation model was connected with genetic algorithms to search the optimal rule curves quickly. The model has been applied to determine the optimal rule curves of the Bhumibol and Sirikit Reservoirs (the Chao Phraya River Basin, Thailand). The optimal rule curves of each condition were used to assess by a Monte Carlo simulation. The results show that the shortest period of dry inflow record using in the simulation model in order to search the optimal rule curves is 10 year. Furthermore, the minimum initial capacity of reservoir for searching optimal rule curves is 10% of full capacity.

  11. Water retention curve for hydrate-bearing sediments

    Science.gov (United States)

    Dai, Sheng; Santamarina, J. Carlos

    2013-11-01

    water retention curve plays a central role in numerical algorithms that model hydrate dissociation in sediments. The determination of the water retention curve for hydrate-bearing sediments faces experimental difficulties, and most studies assume constant water retention curves regardless of hydrate saturation. This study employs network model simulation to investigate the water retention curve for hydrate-bearing sediments. Results show that (1) hydrate in pores shifts the curve to higher capillary pressures and the air entry pressure increases as a power function of hydrate saturation; (2) the air entry pressure is lower in sediments with patchy rather than distributed hydrate, with higher pore size variation and pore connectivity or with lower specimen slenderness along the flow direction; and (3) smaller specimens render higher variance in computed water retention curves, especially at high water saturation Sw > 0.7. Results are relevant to other sediment pore processes such as bioclogging and mineral precipitation.

  12. Growth Curves for Girls with Turner Syndrome

    Science.gov (United States)

    Bertapelli, Fabio; Barros-Filho, Antonio de Azevedo; Antonio, Maria Ângela Reis de Góes Monteiro; Barbeta, Camila Justino de Oliveira; de Lemos-Marini, Sofia Helena Valente

    2014-01-01

    The objective of this study was to review the growth curves for Turner syndrome, evaluate the methodological and statistical quality, and suggest potential growth curves for clinical practice guidelines. The search was carried out in the databases Medline and Embase. Of 1006 references identified, 15 were included. Studies constructed curves for weight, height, weight/height, body mass index, head circumference, height velocity, leg length, and sitting height. The sample ranged between 47 and 1,565 (total = 6,273) girls aged 0 to 24 y, born between 1950 and 2006. The number of measures ranged from 580 to 9,011 (total = 28,915). Most studies showed strengths such as sample size, exclusion of the use of growth hormone and androgen, and analysis of confounding variables. However, the growth curves were restricted to height, lack of information about selection bias, limited distributional properties, and smoothing aspects. In conclusion, we observe the need to construct an international growth reference for girls with Turner syndrome, in order to provide support for clinical practice guidelines. PMID:24949463

  13. Growth Curves for Girls with Turner Syndrome

    Directory of Open Access Journals (Sweden)

    Fabio Bertapelli

    2014-01-01

    Full Text Available The objective of this study was to review the growth curves for Turner syndrome, evaluate the methodological and statistical quality, and suggest potential growth curves for clinical practice guidelines. The search was carried out in the databases Medline and Embase. Of 1006 references identified, 15 were included. Studies constructed curves for weight, height, weight/height, body mass index, head circumference, height velocity, leg length, and sitting height. The sample ranged between 47 and 1,565 (total = 6,273 girls aged 0 to 24 y, born between 1950 and 2006. The number of measures ranged from 580 to 9,011 (total = 28,915. Most studies showed strengths such as sample size, exclusion of the use of growth hormone and androgen, and analysis of confounding variables. However, the growth curves were restricted to height, lack of information about selection bias, limited distributional properties, and smoothing aspects. In conclusion, we observe the need to construct an international growth reference for girls with Turner syndrome, in order to provide support for clinical practice guidelines.

  14. Curve Digitizer – A software for multiple curves digitizing

    Directory of Open Access Journals (Sweden)

    Florentin ŞPERLEA

    2010-06-01

    Full Text Available The Curve Digitizer is software that extracts data from an image file representing a graphicand returns them as pairs of numbers which can then be used for further analysis and applications.Numbers can be read on a computer screen stored in files or copied on paper. The final result is adata set that can be used with other tools such as MSEXCEL. Curve Digitizer provides a useful toolfor any researcher or engineer interested in quantifying the data displayed graphically. The image filecan be obtained by scanning a document

  15. Experimenting with Quantum Fields in Curved Spacetime in the Lab

    CERN Document Server

    Prémont-Schwarz, Isabeau

    2011-01-01

    In this paper we will investigate how one can create emergent curved spacetimes by locally tuning the coupling constants of condensed matter systems. In the continuum limit we thus obtain continuous effective quantum fields living on curved spacetimes. In particular, using Stingnet condensates we can obtain effective electromagnetism. We will show for example how we obtain quantum electrodynamics in a blackhole (Schwarzschild) spacetime.

  16. Rational points on elliptic curves

    CERN Document Server

    Silverman, Joseph H

    2015-01-01

    The theory of elliptic curves involves a pleasing blend of algebra, geometry, analysis, and number theory. This book stresses this interplay as it develops the basic theory, thereby providing an opportunity for advanced undergraduates to appreciate the unity of modern mathematics. At the same time, every effort has been made to use only methods and results commonly included in the undergraduate curriculum. This accessibility, the informal writing style, and a wealth of exercises make Rational Points on Elliptic Curves an ideal introduction for students at all levels who are interested in learning about Diophantine equations and arithmetic geometry. Most concretely, an elliptic curve is the set of zeroes of a cubic polynomial in two variables. If the polynomial has rational coefficients, then one can ask for a description of those zeroes whose coordinates are either integers or rational numbers. It is this number theoretic question that is the main subject of this book. Topics covered include the geometry and ...

  17. Canonical curves with low apolarity

    CERN Document Server

    Ballico, Edoardo; Notari, Roberto

    2010-01-01

    Let $k$ be an algebraically closed field and let $C$ be a non--hyperelliptic smooth projective curve of genus $g$ defined over $k$. Since the canonical model of $C$ is arithmetically Gorenstein, Macaulay's theory of inverse systems allows to associate to $C$ a cubic form $f$ in the divided power $k$--algebra $R$ in $g-2$ variables. The apolarity of $C$ is the minimal number $t$ of linear form in $R$ needed to write $f$ as sum of their divided power cubes. It is easy to see that the apolarity of $C$ is at least $g-2$ and P. De Poi and F. Zucconi classified curves with apolarity $g-2$ when $k$ is the complex field. In this paper, we give a complete, characteristic free, classification of curves $C$ with apolarity $g-1$ (and $g-2$).

  18. Curved spacetimes in the lab

    CERN Document Server

    Szpak, Nikodem

    2014-01-01

    We present some new ideas on how to design analogue models of quantum fields living in curved spacetimes using ultra-cold atoms in optical lattices. We discuss various types of static and dynamical curved spacetimes achievable by simple manipulations of the optical setup. Examples presented here contain two-dimensional spaces of positive and negative curvature as well as homogeneous cosmological models and metric waves. Most of them are extendable to three spatial dimensions. We mention some interesting phenomena of quantum field theory in curved spacetimes which might be simulated in such optical lattices loaded with bosonic or fermionic ultra-cold atoms. We also argue that methods of differential geometry can be used, as an alternative mathematical approach, for dealing with realistic inhomogeneous optical lattices.

  19. The New Keynesian Phillips Curve

    DEFF Research Database (Denmark)

    Ólafsson, Tjörvi

    This paper provides a survey on the recent literature on the new Keynesian Phillips curve: the controversies surrounding its microfoundation and estimation, the approaches that have been tried to improve its empirical fit and the challenges it faces adapting to the open-economy framework. The new...... Keynesian Phillips curve has been severely criticized for poor empirical dynamics. Suggested improvements involve making some adjustments to the standard sticky price framework, e.g. introducing backwardness and real rigidities, or abandoning the sticky price model and relying on models of inattentiveness......, learning or state-dependant pricing. The introduction of openeconomy factors into the new Keynesian Phillips curve complicate matters further as it must capture the nexus between price setting, inflation and the exchange rate. This is nevertheless a crucial feature for any model to be used for inflation...

  20. The Predictive Value of Waist-To-Height Ratio for Ischemic Stroke in a Population-Based Prospective Cohort Study among Mongolian Men in China

    Science.gov (United States)

    Xu, Juan; Xu, Tian; Bu, Xiaoqing; Peng, Hao; Li, Hongmei; Zhang, Mingzhi; Zhang, Yonghong

    2014-01-01

    Objective To explore the associations between waist-to-height ratio (WHtR), body mass index (BMI) and waist circumference (WC) and risk of ischemic stroke among Mongolian men in China. Methods A population-based prospective cohort study was conducted from June 2003 to July 2012 in Inner Mongolia, an autonomous region in north China. A total of 1034 men aged 20 years and older free of cardiovascular disease were included in the cohort and followed up for an average of 9.2 years. The subjects were divided into four groups by WHtR levels (WHtR0.60). The cumulative survival rates of ischemic stroke among the four groups were estimated with the Kaplan-Meier curves and compared by log-rank test. Cox proportional hazards models and Receiver Operating Characteristic (ROC) curves were employed to evaluate the associations between obesity indices and ischemic stroke. Results A total of 47 ischemic stroke patients were observed during the follow-up period. The cumulative incidence and incidence density of ischemic stroke were 4.55% and 507.61/100 000 person-years, respectively. After the major risk factors were adjusted, individuals with WHtR>0.60 had a 3.56-fold increased risk of ischemic stroke compared with those with 0.40≤WHtR≤0.50. Hazard ratio (HR) and 95% confidence intervals (CI) of ischemic stroke for a 1-SD increase in WHtR was 1.34(95% CI: 1.00–1.81). After adding BMI or WC to models, higher WHtR remained significantly associated with increased risk of ischemic stroke. The Kaplan-Meier survival curves showed that the cumulative survival rate in the group with WHtR>0.60 was significantly lower than in the group with 0.40≤WHtR≤0.50 (log-rank test, P = 0.025). The areas under the curve for each index were as follows: 0.586 for WHtR, 0.543 for WC; 0.566 for BMI. Conclusions Higher WHtR is associated with risk of ischemic stroke in Mongolian males. WHtR may be useful in predicting ischemic stroke incidence in males. PMID:25353632

  1. Caloric Curves and Nuclear Expansion

    CERN Document Server

    Natowitz, J B; Ma, Y; Murray, M; Qin, L; Shlomo, S; Wada, R; Wang, J

    2002-01-01

    Nuclear caloric curves have been analyzed using an expanding Fermi gas hypothesis to extract average nuclear densities. In this approach the observed flattening of the caloric curves reflects progressively increasing expansion with increasing excitation energy. This expansion results in a corresponding decrease in the density and Fermi energy of the excited system. For nuclei of medium to heavy mass apparent densities $~0.3\\rho_0$ are reached at the higher excitation energies. The average densities derived in this manner are in good agreement with those derived using other, more complicated, techniques.

  2. Super-quantum curves from super-eigenvalue models

    CERN Document Server

    Ciosmak, Paweł; Manabe, Masahide; Sułkowski, Piotr

    2016-01-01

    In modern mathematical and theoretical physics various generalizations, in particular supersymmetric or quantum, of Riemann surfaces and complex algebraic curves play a prominent role. We show that such supersymmetric and quantum generalizations can be combined together, and construct supersymmetric quantum curves, or super-quantum curves for short. Our analysis is conducted in the formalism of super-eigenvalue models: we introduce $\\beta$-deformed version of those models, and derive differential equations for associated $\\alpha/\\beta$-deformed super-matrix integrals. We show that for a given model there exists an infinite number of such differential equations, which we identify as super-quantum curves, and which are in one-to-one correspondence with, and have the structure of, super-Virasoro singular vectors. We discuss potential applications of super-quantum curves and prospects of other generalizations.

  3. Rational cuspidal curves with four cusps on Hirzebruch surfaces

    Directory of Open Access Journals (Sweden)

    Torgunn Karoline Moe

    2014-10-01

    Full Text Available The purpose of this article is to shed light on the question of how many and what kind of cusps a rational cuspidal curve on a Hirzebruch surface can have. Our main result is a list of rational cuspidal curves with four cusps, their type, cuspidal congurations and the surfaces they lie on. We use birational transformations to construct these curves. Moreover, we find a general expression for and compute the Euler characteristic of the logarithmic tangent sheaf in these cases. Additionally, we show that there exists a real rational cuspidal curve with four real cusps. Last, we show that for rational cuspidal curves with two or more cusps on a Hirzebruch surface, there is a lower bound on one of the multiplicities.

  4. Super-quantum curves from super-eigenvalue models

    Science.gov (United States)

    Ciosmak, Paweł; Hadasz, Leszek; Manabe, Masahide; Sułkowski, Piotr

    2016-10-01

    In modern mathematical and theoretical physics various generalizations, in particular supersymmetric or quantum, of Riemann surfaces and complex algebraic curves play a prominent role. We show that such supersymmetric and quantum generalizations can be combined together, and construct supersymmetric quantum curves, or super-quantum curves for short. Our analysis is conducted in the formalism of super-eigenvalue models: we introduce β-deformed version of those models, and derive differential equations for associated α/ β-deformed super-matrix integrals. We show that for a given model there exists an infinite number of such differential equations, which we identify as super-quantum curves, and which are in one-to-one correspondence with, and have the structure of, super-Virasoro singular vectors. We discuss potential applications of super-quantum curves and prospects of other generalizations.

  5. Super-quantum curves from super-eigenvalue models

    Energy Technology Data Exchange (ETDEWEB)

    Ciosmak, Paweł [Faculty of Mathematics, Informatics and Mechanics, University of Warsaw,ul. Banacha 2, 02-097 Warsaw (Poland); Hadasz, Leszek [M. Smoluchowski Institute of Physics, Jagiellonian University,ul. Łojasiewicza 11, 30-348 Kraków (Poland); Manabe, Masahide [Faculty of Physics, University of Warsaw,ul. Pasteura 5, 02-093 Warsaw (Poland); Sułkowski, Piotr [Faculty of Physics, University of Warsaw,ul. Pasteura 5, 02-093 Warsaw (Poland); Walter Burke Institute for Theoretical Physics, California Institute of Technology,1200 E. California Blvd, Pasadena, CA 91125 (United States)

    2016-10-10

    In modern mathematical and theoretical physics various generalizations, in particular supersymmetric or quantum, of Riemann surfaces and complex algebraic curves play a prominent role. We show that such supersymmetric and quantum generalizations can be combined together, and construct supersymmetric quantum curves, or super-quantum curves for short. Our analysis is conducted in the formalism of super-eigenvalue models: we introduce β-deformed version of those models, and derive differential equations for associated α/β-deformed super-matrix integrals. We show that for a given model there exists an infinite number of such differential equations, which we identify as super-quantum curves, and which are in one-to-one correspondence with, and have the structure of, super-Virasoro singular vectors. We discuss potential applications of super-quantum curves and prospects of other generalizations.

  6. Interpolation and Polynomial Curve Fitting

    Science.gov (United States)

    Yang, Yajun; Gordon, Sheldon P.

    2014-01-01

    Two points determine a line. Three noncollinear points determine a quadratic function. Four points that do not lie on a lower-degree polynomial curve determine a cubic function. In general, n + 1 points uniquely determine a polynomial of degree n, presuming that they do not fall onto a polynomial of lower degree. The process of finding such a…

  7. Variability among polysulphone calibration curves

    Energy Technology Data Exchange (ETDEWEB)

    Casale, G R [University of Rome ' La Sapienza' , Physics Department, P.le A. Moro 2, I-00185, Rome (Italy); Borra, M [ISPESL - Istituto Superiore per la Prevenzione E la Sicurezza del Lavoro, Occupational Hygiene Department, Via Fontana Candida 1, I-0040 Monteporzio Catone (RM) (Italy); Colosimo, A [University of Rome ' La Sapienza' , Department of Human Physiology and Pharmacology, P.le A. Moro 2, I-00185, Rome (Italy); Colucci, M [ISPESL - Istituto Superiore per la Prevenzione E la Sicurezza del Lavoro, Occupational Hygiene Department, Via Fontana Candida 1, I-0040 Monteporzio Catone (RM) (Italy); Militello, A [ISPESL - Istituto Superiore per la Prevenzione E la Sicurezza del Lavoro, Occupational Hygiene Department, Via Fontana Candida 1, I-0040 Monteporzio Catone (RM) (Italy); Siani, A M [University of Rome ' La Sapienza' , Physics Department, P.le A. Moro 2, I-00185, Rome (Italy); Sisto, R [ISPESL - Istituto Superiore per la Prevenzione E la Sicurezza del Lavoro, Occupational Hygiene Department, Via Fontana Candida 1, I-0040 Monteporzio Catone (RM) (Italy)

    2006-09-07

    Within an epidemiological study regarding the correlation between skin pathologies and personal ultraviolet (UV) exposure due to solar radiation, 14 field campaigns using polysulphone (PS) dosemeters were carried out at three different Italian sites (urban, semi-rural and rural) in every season of the year. A polysulphone calibration curve for each field experiment was obtained by measuring the ambient UV dose under almost clear sky conditions and the corresponding change in the PS film absorbance, prior and post exposure. Ambient UV doses were measured by well-calibrated broad-band radiometers and by electronic dosemeters. The dose-response relation was represented by the typical best fit to a third-degree polynomial and it was parameterized by a coefficient multiplying a cubic polynomial function. It was observed that the fit curves differed from each other in the coefficient only. It was assessed that the multiplying coefficient was affected by the solar UV spectrum at the Earth's surface whilst the polynomial factor depended on the photoinduced reaction of the polysulphone film. The mismatch between the polysulphone spectral curve and the CIE erythemal action spectrum was responsible for the variability among polysulphone calibration curves. The variability of the coefficient was related to the total ozone amount and the solar zenith angle. A mathematical explanation of such a parameterization was also discussed.

  8. The New Keynesian Phillips Curve

    DEFF Research Database (Denmark)

    Ólafsson, Tjörvi

    , learning or state-dependant pricing. The introduction of openeconomy factors into the new Keynesian Phillips curve complicate matters further as it must capture the nexus between price setting, inflation and the exchange rate. This is nevertheless a crucial feature for any model to be used for inflation...... forecasting in a small open economy like Iceland....

  9. S-shaped learning curves

    NARCIS (Netherlands)

    Murre, J.M.J.

    2014-01-01

    In this article, learning curves for foreign vocabulary words are investigated, distinguishing between a subject-specific learning rate and a material-specific parameter that is related to the complexity of the items, such as the number of syllables. Two experiments are described, one with Turkish w

  10. Prognostic value of the monoethylglycinexylidide test in alcoholic cirrhosis

    Directory of Open Access Journals (Sweden)

    Bhise Satish

    2007-01-01

    Full Text Available Background: The existing conventional liver function tests (LFTs are indirect, inferior and have limited prognostic value. Therefore, the monoethylglycinexylidide (MEGX test, which provides a direct measure of the actual functional state of the liver, is proposed as a real-time liver function test. The objective of this study was to assess the prognostic value of the MEGX test in cirrhosis by comparing it with Child-Turcotte-Pugh (CTP, the Mayo end stage liver disease (MELD and discriminant function (DF scores. Materials and Methods: The study was carried out in Satara, India during the period of January 2005 to June 2006 and included 79 adult alcoholic cirrhotic patients. The serum specimen from each patient was analyzed using conventional LFTs and the MEGX test. The prognostic scores-CTP, MELD and DF scores were calculated and statistical analyses was performed. Results: Based on receiver operating characteristic (ROC curves, the MELD score and MEGX 60 showed excellent sensitivity and specificity. The comparison of area under ROC curves showed that MELD and MEGX 60 had superior prognostic accuracy when compared to other scores. Kaplan-Meier survival curves for corresponding cutoff values clearly differentiated between patients with different survival times. Conclusion: The MEGX test has shown more sensitivity, specificity and accuracy than CTP and DF scores in determining cases with the possibility of three- and six-month survival. Thus, it can be concluded that MEGX test alongwith MELD, is an effective prognostic tool in the hands of clinicians for predicting short-term survival.

  11. A support theorem for Hilbert schemes of planar curves

    CERN Document Server

    Migliorini, Luca

    2011-01-01

    Consider a family of integral complex locally planar curves whose relative Hilbert scheme of points is smooth. The decomposition theorem of Beilinson, Bernstein, and Deligne asserts that the pushforward of the constant sheaf on the relative Hilbert scheme splits as a direct sum of shifted semisimple perverse sheaves. We will show that no summand is supported in positive codimension. It follows that the perverse filtration on the cohomology of the compactified Jacobian of an integral plane curve encodes the cohomology of all Hilbert schemes of points on the curve. Globally, it follows that a family of such curves with smooth relative compactified Jacobian ("moduli space of D-branes") in an irreducible curve class on a Calabi-Yau threefold will contribute equally to the BPS invariants in the formulation of Pandharipande and Thomas, and in the formulation of Hosono, Saito, and Takahashi.

  12. Amicable pairs and aliquot cycles for elliptic curves

    CERN Document Server

    Stange, Katherine E

    2009-01-01

    An amicable pair for an elliptic curve E/Q is a pair of primes (p,q) of good reduction for E satisfying #E(F_p) = q and #E(F_q) = p. In this paper we study elliptic amicable pairs and analogously defined longer elliptic aliquot cycles. We show that there exist elliptic curves with arbitrarily long aliqout cycles, but that CM elliptic curves (with j not 0) have no aliqout cycles of length greater than two. We give conjectural formulas for the frequency of amicable pairs. For CM curves, the derivation of precise conjectural formulas involves a detailed analysis of the values of the Grossencharacter evaluated at a prime ideal P in End(E) having the property that #E(F_P) is prime. This is especially intricate for the family of curves with j = 0.

  13. A catalog of special plane curves

    CERN Document Server

    Lawrence, J Dennis

    2014-01-01

    Among the largest, finest collections available-illustrated not only once for each curve, but also for various values of any parameters present. Covers general properties of curves and types of derived curves. Curves illustrated by a CalComp digital incremental plotter. 12 illustrations.

  14. Trace elements as tumor biomarkers and prognostic factors in breast cancer: a study through energy dispersive x-ray fluorescence

    Directory of Open Access Journals (Sweden)

    Silva Marina P

    2012-07-01

    Full Text Available Abstract Background The application and better understanding of traditional and new breast tumor biomarkers and prognostic factors are increasing due to the fact that they are able to identify individuals at high risk of breast cancer, who may benefit from preventive interventions. Also, biomarkers can make possible for physicians to design an individualized treatment for each patient. Previous studies showed that trace elements (TEs determined by X-Ray Fluorescence (XRF techniques are found in significantly higher concentrations in neoplastic breast tissues (malignant and benign when compared with normal tissues. The aim of this work was to evaluate the potential of TEs, determined by the use of the Energy Dispersive X-Ray Fluorescence (EDXRF technique, as biomarkers and prognostic factors in breast cancer. Methods By using EDXRF, we determined Ca, Fe, Cu, and Zn trace elements concentrations in 106 samples of normal and breast cancer tissues. Cut-off values for each TE were determined through Receiver Operating Characteristic (ROC analysis from the TEs distributions. These values were used to set the positive or negative expression. This expression was subsequently correlated with clinical prognostic factors through Fisher’s exact test and chi-square test. Kaplan Meier survival curves were also evaluated to assess the effect of the expression of TEs in the overall patient survival. Results Concentrations of TEs are higher in neoplastic tissues (malignant and benign when compared with normal tissues. Results from ROC analysis showed that TEs can be considered a tumor biomarker because, after establishing a cut-off value, it was possible to classify different tissues as normal or neoplastic, as well as different types of cancer. The expression of TEs was found statistically correlated with age and menstrual status. The survival curves estimated by the Kaplan-Meier method showed that patients with positive expression for Cu presented a poor

  15. A learning curve for solar thermal power

    Science.gov (United States)

    Platzer, Werner J.; Dinter, Frank

    2016-05-01

    Photovoltaics started its success story by predicting the cost degression depending on cumulated installed capacity. This so-called learning curve was published and used for predictions for PV modules first, then predictions of system cost decrease also were developed. This approach is less sensitive to political decisions and changing market situations than predictions on the time axis. Cost degression due to innovation, use of scaling effects, improved project management, standardised procedures including the search for better sites and optimization of project size are learning effects which can only be utilised when projects are developed. Therefore a presentation of CAPEX versus cumulated installed capacity is proposed in order to show the possible future advancement of the technology to politics and market. However from a wide range of publications on cost for CSP it is difficult to derive a learning curve. A logical cost structure for direct and indirect capital expenditure is needed as the basis for further analysis. Using derived reference cost for typical power plant configurations predictions of future cost have been derived. Only on the basis of that cost structure and the learning curve levelised cost of electricity for solar thermal power plants should be calculated for individual projects with different capacity factors in various locations.

  16. Numerical Characterization of Piezoceramics Using Resonance Curves

    Science.gov (United States)

    Pérez, Nicolás; Buiochi, Flávio; Brizzotti Andrade, Marco Aurélio; Adamowski, Julio Cezar

    2016-01-01

    Piezoelectric materials characterization is a challenging problem involving physical concepts, electrical and mechanical measurements and numerical optimization techniques. Piezoelectric ceramics such as Lead Zirconate Titanate (PZT) belong to the 6 mm symmetry class, which requires five elastic, three piezoelectric and two dielectric constants to fully represent the material properties. If losses are considered, the material properties can be represented by complex numbers. In this case, 20 independent material constants are required to obtain the full model. Several numerical methods have been used to adjust the theoretical models to the experimental results. The continuous improvement of the computer processing ability has allowed the use of a specific numerical method, the Finite Element Method (FEM), to iteratively solve the problem of finding the piezoelectric constants. This review presents the recent advances in the numerical characterization of 6 mm piezoelectric materials from experimental electrical impedance curves. The basic strategy consists in measuring the electrical impedance curve of a piezoelectric disk, and then combining the Finite Element Method with an iterative algorithm to find a set of material properties that minimizes the difference between the numerical impedance curve and the experimental one. Different methods to validate the results are also discussed. Examples of characterization of some common piezoelectric ceramics are presented to show the practical application of the described methods. PMID:28787875

  17. Optical conductivity of curved graphene.

    Science.gov (United States)

    Chaves, A J; Frederico, T; Oliveira, O; de Paula, W; Santos, M C

    2014-05-07

    We compute the optical conductivity for an out-of-plane deformation in graphene using an approach based on solutions of the Dirac equation in curved space. Different examples of periodic deformations along one direction translates into an enhancement of the optical conductivity peaks in the region of the far- and mid-infrared frequencies for periodicities ∼100 nm. The width and position of the peaks can be changed by dialling the parameters of the deformation profiles. The enhancement of the optical conductivity is due to intraband transitions and the translational invariance breaking in the geometrically deformed background. Furthermore, we derive an analytical solution of the Dirac equation in a curved space for a general deformation along one spatial direction. For this class of geometries, it is shown that curvature induces an extra phase in the electron wave function, which can also be explored to produce interference devices of the Aharonov-Bohm type.

  18. Supersymmetric Spacetimes from Curved Superspace

    CERN Document Server

    Kuzenko, Sergei M

    2015-01-01

    We review the superspace technique to determine supersymmetric spacetimes in the framework of off-shell formulations for supergravity in diverse dimensions using the case of 3D N=2 supergravity theories as an illustrative example. This geometric formalism has several advantages over other approaches advocated in the last four years. Firstly, the infinitesimal isometry transformations of a given curved superspace form, by construction, a finite-dimensional Lie superalgebra, with its odd part corresponding to the rigid supersymmetry transformations. Secondly, the generalised Killing spinor equation, which must be obeyed by the supersymmetry parameters, is a consequence of the more fundamental superfield Killing equation. Thirdly, general rigid supersymmetric theories on a curved spacetime are readily constructed in superspace by making use of the known off-shell supergravity-matter couplings and restricting them to the background chosen. It is the superspace techniques which make it possible to generate arbitra...

  19. Curved canals: Ancestral files revisited

    Directory of Open Access Journals (Sweden)

    Jain Nidhi

    2008-01-01

    Full Text Available The aim of this article is to provide an insight into different techniques of cleaning and shaping of curved root canals with hand instruments. Although a plethora of root canal instruments like ProFile, ProTaper, LightSpeed ® etc dominate the current scenario, the inexpensive conventional root canal hand files such as K-files and flexible files can be used to get optimum results when handled meticulously. Special emphasis has been put on the modifications in biomechanical canal preparation in a variety of curved canal cases. This article compiles a series of clinical cases of root canals with curvatures in the middle and apical third and with S-shaped curvatures that were successfully completed by employing only conventional root canal hand instruments.

  20. A Study of Hyperelliptic Curves in Cryptography

    Directory of Open Access Journals (Sweden)

    Reza Alimoradi

    2016-08-01

    Full Text Available Elliptic curves are some specific type of curves known as hyper elliptic curves. Compared to the integer factorization problem(IFP based systems, using elliptic curve based cryptography will significantly decrease key size of the encryption. Therefore, application of this type of cryptography in systems that need high security and smaller key size has found great attention. Hyperelliptic curves help to make key length shorter. Many investigations are done with regard to improving computations, hardware and software implementation of these curves, their security and resistance against attacks. This paper studies and analyzes researches done about security and efficiency of hyperelliptic curves.

  1. Elastic Curves on the Sphere

    Science.gov (United States)

    1992-12-16

    12 = (K,, + )- (29) K 2 (see [3]). The parameter KM represents the amplitude of the periodic curva - ture function and sm denotes the value at which K...Additamentum De curvis elasticis. Methodus Inveniendi Lineas Curvas Maximi Minimive Proprietate Gaudentes, Ser. 1., Vol. 24, Lausanne 1744. 17 [10...Mathematical Theory of Elasticity. 4th. ed., Cambridge University Press, 1927. [12] G. Nielson. Bernstein/ Bezier Curves and Splines on Spheres based upon

  2. Accelerating Around an Unbanked Curve

    Science.gov (United States)

    Mungan, Carl E.

    2006-02-01

    The December 2004 issue of TPT presented a problem concerning how a car should accelerate around an unbanked curve of constant radius r starting from rest if it is to avoid skidding. Interestingly enough, two solutions were proffered by readers.2 The purpose of this note is to compare and contrast the two approaches. Further experimental investigation of various turning strategies using a remote-controlled car and overhead video analysis could make for an interesting student project.

  3. Implementation Learning and Forgetting Curve to Scheduling in Garment Industry

    Science.gov (United States)

    Muhamad Badri, Huda; Deros, Baba Md; Syahri, M.; Saleh, Chairul; Fitria, Aninda

    2016-02-01

    The learning curve shows the relationship between time and the cumulative number of units produced which using the mathematical description on the performance of workers in performing repetitive works. The problems of this study is level differences in the labors performance before and after the break which affects the company's production scheduling. The study was conducted in the garment industry, which the aims is to predict the company production scheduling using the learning curve and forgetting curve. By implementing the learning curve and forgetting curve, this paper contributes in improving the labors performance that is in line with the increase in maximum output 3 hours productive before the break are 15 unit product with learning curve percentage in the company is 93.24%. Meanwhile, the forgetting curve improving maximum output 3 hours productive after the break are 11 unit product with the percentage of forgetting curve in the company is 92.96%. Then, the obtained 26 units product on the productive hours one working day is used as the basic for production scheduling.

  4. Atlas of Secular Light Curves of Comets

    Science.gov (United States)

    Ferrin, Ignacio

    2007-12-01

    We have completed work on the secular light curves of 30 periodic and non-periodic comets. The objectives and approach of this project has been explained in Ferrin (Icarus, 178, 493-516, 2005). Each comet requires 2 plots. The time plot shows the reduced (to Δ = 1 AU) magnitude of the comet as a function of time, thus displaying the brightness history of the object. The log plot is a reflected double log plot. The reflection takes place at R=1 AU, to allow the determination of the absolute magnitude by extrapolation. 22 photometric parameters are measured from the plots, most of them new. The plots have been collected in a document that constitutes "The Atlas". We have defined a photometric age, P-AGE, that attempts to measure the age of a comet based on its activity. P-AGE has been scaled to human ages to help in its interpretation. We find that comets Hale-Bopp and 29P/SW 1, are baby comets (P-AGE 100 cy). The secular light curve of 9P/Tempel 1 exhibits sublimation due to H2O and due to CO. Comet 67P/Churyumov-Gerasimento to be visited by the Rossetta spacecraft in 2014 exhibits a photometric anomaly. Comet 65P/Gunn exhibits a lag in maximum brightness of LAG = + 254 days after perihelion. We suggest that the pole is pointing to the sun at that time. The secular light curves will be presented and a preliminary interpretation will be advanced. The secular light curves present complexity beyond current understanding. The observations described in this work were carried out at the National Observatory of Venezuela (ONV), managed by the Center for Research in Astronomy (CIDA), for the Ministry of Science and Technology (MinCyT).

  5. High accuracy & long timescale light curves

    Directory of Open Access Journals (Sweden)

    Hodgkin S.

    2013-04-01

    Full Text Available We present a theoretical analysis of the optical light curves (LCs for short-period high-mass transiting extrasolar planet systems. Our method considers the primary transit, the secondary eclipse, and the overall phase shape of the LC between the occultations. Phase variations arise from (i reflected and thermally emitted light by the planet, (ii the ellipsoidal shape of the star due to the gravitational pull of the planet, and (iii the Doppler shift of the stellar light as the star orbits the center of mass of the system. Our full model of the out-of-eclipse variations contains information about the planetary mass, orbital eccentricity, the orientation of periastron and the planet's albedo. For a range of hypothetical systems we demonstrate that the ellipsoidal variations (ii. can be large enough to be distinguished from the remaining components and that this effect can be used to constrain the planet's mass. As an example we presend KOI-13b (candidate exoplanet system included in the September 2011 Kepler data release. The Kepler light curve shows both primary and secondary eclipses, as well as significant out-of-eclipse light curve variations. We model the relative contributions from (i thermal emission from the companion, (ii planetary reflected light, (iii doppler beaming, and (iv ellipsoidal variations in the host-star arising from the tidal distortion of the host star by its companion. Our analysis, based on the light curve alone, enables us to constrain the mass of the KOI-13.01 companion to be MC = 8.3 ± 1.25 MJ and thus demonstrates that the transiting companion is a planet. The teqnique is useful for current and future space missions such as Kepler and PLATO.

  6. Pro-A-type natriuretic peptide and pro-adrenomedullin predict progression of chronic kidney disease: the MMKD Study.

    Science.gov (United States)

    Dieplinger, Benjamin; Mueller, Thomas; Kollerits, Barbara; Struck, Joachim; Ritz, Eberhard; von Eckardstein, Arnold; Haltmayer, Meinhard; Kronenberg, Florian

    2009-02-01

    A-type natriuretic peptide (ANP) and adrenomedullin (ADM) are potent hypotensive, diuretic, and natriuretic peptides involved in maintaining cardiovascular and renal homeostasis. We conducted a prospective 7-year study of 177 nondiabetic patients with primary chronic kidney disease to see if ANP and ADM plasma concentrations predict the progression of their disease, using novel sandwich immunoassays covering the midregional epitopes of the stable prohormones (MRproANP and MR-proADM). Progression of chronic kidney disease was defined as doubling of baseline serum creatinine and/or terminal renal failure, which occurred in 65 patients. Analysis of the receiver operating characteristic curve for the prediction of renal endpoints showed similar areas under the curve for the glomerular filtration rate (GFR) (0.838), MR-proANP (0.810), and MRproADM (0.876), respectively, as did the Kaplan-Meier curve analyses of the patients stratified according to the median of the respective markers. In separate multiple Cox-proportional hazard regression analyses, increased plasma concentrations of both peptides were each strongly predictive of the progression of chronic kidney disease after adjustments for age, gender, GFR, proteinuria and amino-terminal pro-B-type natriuretic peptide. Our study suggests that MR-proANP and MR-proADM are useful new markers of progression of primary nondiabetic chronic kidney disease.

  7. Macdonald formula for curves with planar singularities

    CERN Document Server

    Maulik, Davesh

    2011-01-01

    We generalize Macdonald's formula for the cohomology of Hilbert schemes of points on a curve from smooth curves to curves with planar singularities: we relate the cohomology of the Hilbert schemes to the cohomology of the compactified Jacobian of the curve. The new formula is a consequence of a stronger identity between certain perverse sheaves defined by a family of curves satisfying mild conditions, whose proof makes an essential use of Ng\\^o's support theorem for compactified Jacobians.

  8. 18F-FDG PET/CT for Early Postradiotherapy Assessment in Solitary Bone Plasmacytomas.

    Science.gov (United States)

    Alongi, Pierpaolo; Zanoni, Lucia; Incerti, Elena; Fallanca, Federico; Mapelli, Paola; Papathanasiou, Nikolaos; Gianolli, Luigi; Picchio, Maria; Bomanji, Jamshed

    2015-08-01

    The purpose of this study was to evaluate the performance and possible prognostic value of early (18)F-FDG PET/CT (FDG PET/CT) assessment after radiotherapy (RT) in patients with solitary bone plasmacytoma (SBP). Twenty-one patients affected by SBP who underwent FDG PET/CT scan for early restaging (≤6 months) postradiotherapy assessment were selected from the PET databases of University College London Hospital of London and San Raffaele Hospital of Milan. Patients with no abnormal uptake were classified as having no pathologic uptake (NPU). A SUV(max) cutoff value of 4 was chosen to discriminate minimal residual uptake (MRU; SUV(max) ≤ 4) from pathologic uptake (PU, SUV(max) >4). Progression-free survival (PFS) rate was estimated using Kaplan-Meier curves and Cox regression analysis. In 10 of 21 patients restaged by FDG PET/CT, further previous baseline scan was available also at staging, and results showed positive findings at the level of all biopsy-proven disease areas.Considering MRU as PU, FDG PET/CT showed a sensitivity and specificity of 86% and 29%, respectively. Using SUV(max) >4 as the cutoff, sensitivity and specificity were 86% and 93%, respectively. Kaplan-Meier curves revealed a significant difference in PFS probability between patients classified as positive on FDG PET/CT using a cutoff of SUV(max) >4 (PU) and those classified as negative (NPU + MRU) (log-rank, Mantel-Cox, P = 0.009; χ(2) = 6.85). Cox regression analysis of PFS using SUV(max) >4 as cutoff revealed an interesting relation in prediction of progression (HR, 9.458). (18)F-FDG PET/CT for early restaging after RT in patients with SBP should be considered carefully in view of the lack of specificity of a low SUV(max) value. The good correlation between a high SUV(max) value and follow-up suggests a possible prognostic role for FDG PET/CT in disease progression at early restaging after RT.

  9. Increased expression of CD133 and reduced dystroglycan expression are strong predictors of poor outcome in colon cancer patients

    Directory of Open Access Journals (Sweden)

    Coco Claudio

    2012-09-01

    Full Text Available Abstract Background Expression levels of CD133, a cancer stem cell marker, and of the α-subunit of the dystroglycan (α-DG complex, have been previously reported to be altered in colorectal cancers. Methods Expression levels of CD133 and α-DG were assessed by immunohistochemistry in a series of colon cancers and their prognostic significance was evaluated. Results Scattered cells positive for CD133 were rarely detected at the bases of the crypts in normal colonic mucosa while in cancer cells the median percentage of positive cells was 5% (range 0–80. A significant correlation was observed with pT parameter and tumor stage but not with tumor grade and N status. Recurrence and death from disease were significantly more frequent in CD133-high expressing tumors and Kaplan-Meier curves showed a significant separation between high vs low expressor groups for both disease-free (p = 0.002 and overall (p = 0.008 survival. Expression of α-DG was reduced in a significant fraction of tumors but low α-DG staining did not correlate with any of the classical clinical-pathological parameters. Recurrence and death from the disease were significantly more frequent in α-DG-low expressing tumors and Kaplan-Meier curves showed a significant separation between high vs low expressor tumors for both disease-free (p = 0.02 and overall (p = 0.02 survival. Increased expression of CD133, but not loss of α-DG, confirmed to be an independent prognostic parameters at a multivariate analysis associated with an increased risk of recurrence (RR = 2.4; p = 0.002 and death (RR = 2.3; p = 0.003. Conclusions Loss of α-DG and increased CD133 expression are frequent events in human colon cancer and evaluation of CD133 expression could help to identify high-risk colon cancer patients.

  10. Survival Analysis of Patients with End Stage Renal Disease

    Science.gov (United States)

    Urrutia, J. D.; Gayo, W. S.; Bautista, L. A.; Baccay, E. B.

    2015-06-01

    This paper provides a survival analysis of End Stage Renal Disease (ESRD) under Kaplan-Meier Estimates and Weibull Distribution. The data were obtained from the records of V. L. MakabaliMemorial Hospital with respect to time t (patient's age), covariates such as developed secondary disease (Pulmonary Congestion and Cardiovascular Disease), gender, and the event of interest: the death of ESRD patients. Survival and hazard rates were estimated using NCSS for Weibull Distribution and SPSS for Kaplan-Meier Estimates. These lead to the same conclusion that hazard rate increases and survival rate decreases of ESRD patient diagnosed with Pulmonary Congestion, Cardiovascular Disease and both diseases with respect to time. It also shows that female patients have a greater risk of death compared to males. The probability risk was given the equation R = 1 — e-H(t) where e-H(t) is the survival function, H(t) the cumulative hazard function which was created using Cox-Regression.

  11. Adaptive zero-tree structure for curved wavelet image coding

    Science.gov (United States)

    Zhang, Liang; Wang, Demin; Vincent, André

    2006-02-01

    We investigate the issue of efficient data organization and representation of the curved wavelet coefficients [curved wavelet transform (WT)]. We present an adaptive zero-tree structure that exploits the cross-subband similarity of the curved wavelet transform. In the embedded zero-tree wavelet (EZW) and the set partitioning in hierarchical trees (SPIHT), the parent-child relationship is defined in such a way that a parent has four children, restricted to a square of 2×2 pixels, the parent-child relationship in the adaptive zero-tree structure varies according to the curves along which the curved WT is performed. Five child patterns were determined based on different combinations of curve orientation. A new image coder was then developed based on this adaptive zero-tree structure and the set-partitioning technique. Experimental results using synthetic and natural images showed the effectiveness of the proposed adaptive zero-tree structure for encoding of the curved wavelet coefficients. The coding gain of the proposed coder can be up to 1.2 dB in terms of peak SNR (PSNR) compared to the SPIHT coder. Subjective evaluation shows that the proposed coder preserves lines and edges better than the SPIHT coder.

  12. Supersymmetry in Lorentzian Curved Spaces and Holography

    CERN Document Server

    Cassani, Davide; Martelli, Dario; Tomasiello, Alessandro; Zaffaroni, Alberto

    2012-01-01

    We consider superconformal and supersymmetric field theories on four-dimensional Lorentzian curved space-times, and their five-dimensional holographic duals. As in the Euclidean signature case, preserved supersymmetry for a superconformal theory is equivalent to the existence of a charged conformal Killing spinor. Differently from the Euclidean case, we show that the existence of such spinors is equivalent to the existence of a null conformal Killing vector. For a supersymmetric field theory with an R-symmetry, this vector field is further restricted to be Killing. We demonstrate how these results agree with the existing classification of supersymmetric solutions of minimal gauged supergravity in five dimensions.

  13. Heterotic String Models in Curved Spacetime

    CERN Document Server

    Bars, Itzhak

    1992-01-01

    We explore the possibility of string theories in only four spacetime dimensions without any additional compactified dimensions. We show that, provided the theory is defined in curved spacetime that has a cosmological interpration, it is possible to construct consistent heterotic string theories based on a few non-compact current algebra cosets. We classify these models. The gauge groups that emerge fall within a remarkably narrow range and include the desirable low energy flavor symmetry of $SU(3)\\times SU(2)\\times U(1)$. The quark and lepton states, which come in color triplets and $SU(2)$ doublets, are expected to emerge in several families.

  14. Discreteness of Curved Spacetime from GUP

    Directory of Open Access Journals (Sweden)

    Ahmad Adel Abutaleb

    2013-01-01

    Full Text Available Diverse theories of quantum gravity expect modifications of the Heisenberg's uncertainty principle near the Planck scale to a so-called Generalized uncertainty principle (GUP. It was shown by some authors that the GUP gives rise to corrections to the Schrodinger , Klein-Gordon, and Dirac equations. By solving the GUP corrected equations, the authors arrived at quantization not only of energy but also of box length, area, and volume. In this paper, we extend the above results to the case of curved spacetime (Schwarzschild metric. We showed that we arrived at the quantization of space by solving Dirac equation with GUP in this metric.

  15. The Bell Curve: An Essay Review

    Directory of Open Access Journals (Sweden)

    John C. Culbertson

    1995-02-01

    Full Text Available Occasionally a book out of academia will break from scholarly circles and enter into the mainstream market. On even rarer occasions, it will gain considerable notoriety before its initial publication. Richard Herrnstein and Charles Murray's The Bell Curve: Intelligence and Class Structure in American Life is such a book. Currently, it has entered the New York Times best- sellers list and appeared in most academic and mainstream periodical book reviews. Direct publicity for the book has also been strong. Although Herrnstein died September 24 of the past year, Murray has appeared on many popular television and radio talk shows.

  16. New estimators of the extreme value index under random right censoring, for heavy-tailed distributions

    OpenAIRE

    Worms, Julien; Worms, Rym

    2014-01-01

    International audience; This paper presents new approaches for the estimation of the extreme value index in the framework of randomly censored (from the right) samples, based on the ideas of Kaplan-Meier integration and the synthetic data approach of S.Leurgans (1987). These ideas are developed here in the heavy tail case and for the adaptation of the Hill estimator, for which the consistency is proved under first order conditions. Simulations show good performance of the two approaches, with...

  17. Stereo Matching of Planar Curves Composed of Time Stamped Points

    Institute of Scientific and Technical Information of China (English)

    Wang Shuwen; Zhang Tianxu

    2006-01-01

    Matching features such as curve segments in stereo images play a very important role in scene reconstruction. In this paper, a stereo matching algorithm for the trajectories composed of time stamped points is proposed. Based on time stamped points, planar curve match measurements are given first, such as time constraint, cross-ratio invariant constraint and epipolar geometry constraint;then, a trajectory matching method is proposed based on epipolar geometry constraint and cross-ratio invariant constraint. In order to match the planar curve segments projected by perspective projection system, the curve start time and end time are selected first to prepare match candidates. Then, the epipolar equation is used to discard the unmatched curve segment candidates. At last, a cross ratio invariant constraint is used to find the most matched curve segments. If their match measurement is higher than the specialized threshold, a candidate with the least cross ratio difference is then selected as the match result; otherwise, no match is found. Unlike the conventional planar curve segments matching algorithm, this paper presents a weakly calibrated binocular stereo vision system which is based on wide baseline. The stamped points are obtained by targets detecting method of flying objects from image sequences.Due to wide baseline, there must exist the projection not in epipolar monotonic order or the curve segments located in very short distance and keeping the epipolar monotonic order. By using the method mentioned above, experiments are made to match planar curve segments not only in epipolar monotonic order but also not in epipolar monotonic order. The results show that the performance of our curve matching algorithm is effective for matching the arc-like planar trajectories composed of time stamped points.

  18. Evolution of dust extinction curves in galaxy simulation

    Science.gov (United States)

    Hou, Kuan-Chou; Hirashita, Hiroyuki; Nagamine, Kentaro; Aoyama, Shohei; Shimizu, Ikkoh

    2017-07-01

    To understand the evolution of extinction curve, we calculate the dust evolution in a galaxy using smoothed particle hydrodynamic simulations incorporating stellar dust production, dust destruction in supernova shocks, grain growth by accretion and coagulation, and grain disruption by shattering. The dust species are separated into carbonaceous dust and silicate. The evolution of grain size distribution is considered by dividing grain population into large and small grains, which allows us to estimate extinction curves. We examine the dependence of extinction curves on the position, gas density and metallicity in the galaxy, and find that extinction curves are flat at t ≲ 0.3 Gyr because stellar dust production dominates the total dust abundance. The 2175 Å bump and far-ultraviolet (FUV) rise become prominent after dust growth by accretion. At t ≳ 3 Gyr, shattering works efficiently in the outer disc and low-density regions, so extinction curves show a very strong 2175 Å bump and steep FUV rise. The extinction curves at t ≳ 3 Gyr are consistent with the Milky Way extinction curve, which implies that we successfully included the necessary dust processes in the model. The outer disc component caused by stellar feedback has an extinction curve with a weaker 2175 Å bump and flatter FUV slope. The strong contribution of carbonaceous dust tends to underproduce the FUV rise in the Small Magellanic Cloud extinction curve, which supports selective loss of small carbonaceous dust in the galaxy. The snapshot at young ages also explains the extinction curves in high-redshift quasars.

  19. The structure of uniform B-spline curves with parameters

    Institute of Scientific and Technical Information of China (English)

    Juan Cao; Guozhao Wang

    2008-01-01

    The shape-adjustable curve constructed by uniform B-spline basis function with parameter is an extension of uniform B-spline curve. In this paper, we study the relation between the uniform B-spline basis functions with parameter and the B-spline basis functions. Based on the degree elevation of B-spline, we extend the uniform B-spline basis functions with parameter to ones with multiple parameters. Examples show that the proposed basis functions provide more flexibility for curve design.

  20. Points of Low Degree on Smooth Plane Curves

    CERN Document Server

    Debarre, O; Debarre, Olivier; Klassen, Matthew

    1992-01-01

    The purpose of this note is to provide some applications of Faltings' recent proof of S. Lang's conjecture to smooth plane curves. Let $C$ be a smooth plane curve defined by an equation of degree $d$ with integral coefficients. We show that for $d\\ge 7$, the curve $C$ has only finitely many points whose field of definition has degree $\\le d-2$ over $Q$, and that for $d\\ge 8$, all but finitely many points of $C$ whose field of definition has degree $\\le d-1$ over $Q$ arise as points of intersection of rational lines through rational points of $C$.

  1. Arithmetic properties of non-hyperelliptic genus 3 curves

    OpenAIRE

    Lorenzo García, Elisa

    2014-01-01

    This thesis explores the explicit computation of twists of curves. We develope an algorithm for computing the twists of a given curve assuming that its automorphism group is known. And in the particular case in which the curve is non-hyperelliptic we show how to compute equations of the twists. The algorithm is based on a correspondence that we establish beetwen the set of twists and the set of solutions of a certain Galois embedding problem. In general is not known how to compute all the sol...

  2. Integrable systems and symmetric products of curves

    CERN Document Server

    Vanhaecke, P

    1994-01-01

    show how there is associated to each non-constant polynomial F(x,y) a completely integrable system with polynomial invariants on \\Rd and on \\C{2d} for each d\\geq1; in fact the invariants are not only in involution for one Poisson bracket, but for a large class of polynomial Poisson brackets, indexed by the family of polynomials in two variables. We show that the complex invariant manifolds are isomorphic to affine parts of d-fold symmetric products of a deformation of the algebraic curve F(x,y)=0, and derive the structure of the real invariant manifolds from it. We also exhibit Lax equations for the hyperelliptic case (i.e., when F(x,y) is of the form y^2+f(x)) and we show that in this case the invariant manifolds are affine parts of distinguished (non-linear) subvarieties of the Jacobians of the curves. As an application the geometry of the H\\'enon-Heiles hierarchy --- a family of superimposable integrable polynomial potentials on the plane --- is revealed and Lax equations for the hierarchy are given.

  3. LINS Curve in Romanian Economy

    Directory of Open Access Journals (Sweden)

    Emilian Dobrescu

    2016-02-01

    Full Text Available The paper presents theoretical considerations and empirical evidence to test the validity of the Laffer in Narrower Sense (LINS curve as a parabola with a maximum. Attention is focused on the so-called legal-effective tax gap (letg. The econometric application is based on statistical data (1990-2013 for Romania as an emerging European economy. Three cointegrating regressions (fully modified least squares, canonical cointegrating regression and dynamic least squares and three algorithms, which are based on instrumental variables (two-stage least squares, generalized method of moments, and limited information maximum likelihood, are involved.

  4. Sound propagation over curved barriers

    Science.gov (United States)

    Pierce, Allan D.; Main, Geoffrey L.; Kearns, James A.; Hsieh, H.-A.

    1986-01-01

    Wide barriers with curved tops are studied with emphasis placed on circumstances whereby the local radius of curvature R of the barrier is continuous along the surface and is large compared to a wavelength. Results analogous to those given by Hayek et al. (1978) are reviewed and extended to cases where the radius of curvature and the surface impedance may vary with position. Circumstances not easily interpreted within the framework of the model proposed by Keller (1956) and Hayek et al. are also considered.

  5. Reconfigurable Double-Curved Mould

    DEFF Research Database (Denmark)

    Raun, Christian; Kirkegaard, Poul Henning

    2012-01-01

    . This happens fast, automatic and without production of waste, and the manipulated surface is fair and robust, eliminating the need for additional, manual treatment. Limitations to the possibilities of the flexible form are limited curvature and limited level of detail, making it especially suited for larger......, double curved surfaces like facades or walls, where the curvature of each element is relatively small in comparison to the overall shape. In the proposed dynamic mould system, where only a set of points is defined, a stiff membrane interpolates the surface between points. To function as a surface...

  6. Membranes Wrapped on Holomorphic Curves

    CERN Document Server

    Gauntlett, J P; Pakis, S; Waldram, D; Gauntlett, Jerome P.; Kim, Nakwoo; Pakis, Stathis; Waldram, Daniel

    2002-01-01

    We construct supergravity solutions dual to the twisted field theories arising when M-theory membranes wrap holomorphic curves in Calabi-Yau n-folds. The solutions are constructed in an Abelian truncation of maximal D=4 gauged supergravity and then uplifted to D=11. For four-folds and five-folds we find new smooth AdS/CFT examples and for all cases we analyse the nature of the singularities that arise. Our results provide an interpretation of certain charged topological AdS black holes. We also present the generalised calibration two-forms for the solutions.

  7. Tangent lines, inflections, and vertices of closed curves

    CERN Document Server

    Ghomi, Mohammad

    2012-01-01

    We show that every smooth closed curve C immersed in Euclidean 3-space satisfies the sharp inequality 2(P+I)+V >5 which relates the numbers P of pairs of parallel tangent lines, I of inflections (or points of vanishing curvature), and V of vertices (or points of vanishing torsion) of C. We also show that 2(P'+I)+V >3, where P' is the number of pairs of concordant parallel tangent lines. The proofs, which employ curve shortening flow with surgery, are based on corresponding inequalities for the numbers of double points, singularities, and inflections of closed curves in the real projective plane and the sphere which intersect every closed geodesic. These findings extend some classical results in curve theory including works of Moebius, Fenchel, and Segre, which is also known as Arnold's "tennis ball theorem".

  8. Projection of curves on B-spline surfaces using quadratic reparameterization

    KAUST Repository

    Yang, Yijun

    2010-09-01

    Curves on surfaces play an important role in computer aided geometric design. In this paper, we present a hyperbola approximation method based on the quadratic reparameterization of Bézier surfaces, which generates reasonable low degree curves lying completely on the surfaces by using iso-parameter curves of the reparameterized surfaces. The Hausdorff distance between the projected curve and the original curve is controlled under the user-specified distance tolerance. The projected curve is T-G 1 continuous, where T is the user-specified angle tolerance. Examples are given to show the performance of our algorithm. © 2010 Elsevier Inc. All rights reserved.

  9. Foliations on the moduli space of curves, vanishing in cohomology, and Calogero-Moser curves

    CERN Document Server

    Grushevsky, Samuel

    2011-01-01

    Using meromorphic differentials with real periods, we show that a certain tautological homology class on the moduli space of smooth algebraic curves of genus g vanishes. The vanishing of the entire tautological ring for degree g-1 and higher, part of Faber's conjecture, is known in both homology and Chow --- it was proven by Looijenga, Ionel, and Graber-Vakil, and the class that we show vanishes is just one such tautological class. However, our approach, motivated by the Whitham perturbation theory of soliton equations, is completely new, elementary in the sense that no techniques beyond elementary complex analysis are used, and also leads to a natural non-speciality conjecture, which would imply many more vanishing results and relations among tautological classes. In the course of the proof we define and study foliations of the moduli space of curves constructed using periods of meromorphic differentials, in a way providing for meromorphic differentials a theory similar to that developed for abelian differen...

  10. Potential prognostic marker ubiquitin carboxyl-terminal hydrolase-L1 does not predict patient survival in non-small cell lung carcinoma

    Directory of Open Access Journals (Sweden)

    Maxwell Perry

    2011-08-01

    Full Text Available Abstract Background Ubiquitin Carboxyl-Terminal Hydrolase-L1 (UCH-L1 is a deubiquitinating enzyme that is highly expressed throughout the central and peripheral nervous system and in cells of the diffuse neuroendocrine system. Aberrant function of UCH-L1 has been associated with neurological disorders such as Parkinson's disease and Alzheimer's disease. Moreover, UCH-L1 exhibits a variable expression pattern in cancer, acting either as a tumour suppressor or promoter, depending on the type of cancer. In non-small cell lung carcinoma primary tumour samples, UCH-L1 is highly expressed and is associated with an advanced tumour stage. This suggests UCH-L1 may be involved in oncogenic transformation and tumour invasion in NSCLC. However, the functional significance of UCH-L1 in the progression of NSCLC is unclear. The aim of this study was to investigate the role of UCH-L1 using NSCLC cell line models and to determine if it is clinically relevant as a prognostic marker for advanced stage disease. Methods UCH-L1 expression in NSCLC cell lines H838 and H157 was modulated by siRNA-knockdown, and the phenotypic changes were assessed by flow cytometry, haematoxylin & eosin (H&E staining and poly (ADP-ribose polymerase (PARP cleavage. Metastatic potential was measured by the presence of phosphorylated myosin light chain (MLC2. Tumour microarrays were examined immunohistochemically for UCH-L1 expression. Kaplan-Meier curves were generated using UCH-L1 expression levels and patient survival data extracted from Gene Expression Omnibus data files. Results Expression of UCH-L1 was decreased by siRNA in both cell lines, resulting in increased cell death in H838 adenocarcinoma cells but not in the H157 squamous cell line. However, metastatic potential was reduced in H157 cells. Immunohistochemical staining of UCH-L1 in patient tumours confirmed it was preferentially expressed in squamous cell carcinoma rather than adenocarcinoma. However the Kaplan-Meier curves

  11. Differential geometry and topology of curves

    CERN Document Server

    Animov, Yu

    2001-01-01

    Differential geometry is an actively developing area of modern mathematics. This volume presents a classical approach to the general topics of the geometry of curves, including the theory of curves in n-dimensional Euclidean space. The author investigates problems for special classes of curves and gives the working method used to obtain the conditions for closed polygonal curves. The proof of the Bakel-Werner theorem in conditions of boundedness for curves with periodic curvature and torsion is also presented. This volume also highlights the contributions made by great geometers. past and present, to differential geometry and the topology of curves.

  12. Smarandache Curves in Minkowski Space-time

    OpenAIRE

    Turgut, Melih; Yilmaz, Suha

    2008-01-01

    A regular curve in Minkowski space-time, whose position vector is composed by Frenet frame vectors on another regular curve, is called a Smarandache Curve. In this paper, we define a special case of such curves and call it Smarandache TB2 Curves in the space E41. Moreover, we compute formulas of its Frenet apparatus according to base curve via the method expressed in [3]. By this way, we obtain an another orthonormal frame of E41.

  13. Dirac operators on noncommutative curved spacetimes

    CERN Document Server

    Schenkel, Alexander

    2013-01-01

    We study Dirac operators in the framework of twist-deformed noncommutative geometry. The definition of noncommutative Dirac operators is not unique and we focus on three different ones, each generalizing the commutative Dirac operator in a natural way. We show that the three definitions are mutually inequivalent, and that demanding formal self-adjointness with respect to a suitable inner product singles out a preferred choice. A detailed analysis shows that, if the Drinfeld twist contains sufficiently many Killing vector fields, the three operators coincide, which can simplify explicit calculations considerably. We then turn to the construction of quantized Dirac fields on noncommutative curved spacetimes. We show that there exist unique retarded and advanced Green's operators and construct a canonical anti-commutation relation algebra. In the last part we study noncommutative Minkowski and AdS spacetimes as explicit examples.

  14. Flow characteristics of curved ducts

    Directory of Open Access Journals (Sweden)

    Rudolf P.

    2007-10-01

    Full Text Available Curved channels are very often present in real hydraulic systems, e.g. curved diffusers of hydraulic turbines, S-shaped bulb turbines, fittings, etc. Curvature brings change of velocity profile, generation of vortices and production of hydraulic losses. Flow simulation using CFD techniques were performed to understand these phenomena. Cases ranging from single elbow to coupled elbows in shapes of U, S and spatial right angle position with circular cross-section were modeled for Re = 60000. Spatial development of the flow was studied and consequently it was deduced that minor losses are connected with the transformation of pressure energy into kinetic energy and vice versa. This transformation is a dissipative process and is reflected in the amount of the energy irreversibly lost. Least loss coefficient is connected with flow in U-shape elbows, biggest one with flow in Sshape elbows. Finally, the extent of the flow domain influenced by presence of curvature was examined. This isimportant for proper placement of mano- and flowmeters during experimental tests. Simulations were verified with experimental results presented in literature.

  15. Capacity theory on algebraic curves

    CERN Document Server

    Rumely, Robert S

    1989-01-01

    Capacity is a measure of size for sets, with diverse applications in potential theory, probability and number theory. This book lays foundations for a theory of capacity for adelic sets on algebraic curves. Its main result is an arithmetic one, a generalization of a theorem of Fekete and Szegö which gives a sharp existence/finiteness criterion for algebraic points whose conjugates lie near a specified set on a curve. The book brings out a deep connection between the classical Green's functions of analysis and Néron's local height pairings; it also points to an interpretation of capacity as a kind of intersection index in the framework of Arakelov Theory. It is a research monograph and will primarily be of interest to number theorists and algebraic geometers; because of applications of the theory, it may also be of interest to logicians. The theory presented generalizes one due to David Cantor for the projective line. As with most adelic theories, it has a local and a global part. Let /K be a smooth, complet...

  16. Miniature curved artificial compound eyes.

    Science.gov (United States)

    Floreano, Dario; Pericet-Camara, Ramon; Viollet, Stéphane; Ruffier, Franck; Brückner, Andreas; Leitel, Robert; Buss, Wolfgang; Menouni, Mohsine; Expert, Fabien; Juston, Raphaël; Dobrzynski, Michal Karol; L'Eplattenier, Geraud; Recktenwald, Fabian; Mallot, Hanspeter A; Franceschini, Nicolas

    2013-06-04

    In most animal species, vision is mediated by compound eyes, which offer lower resolution than vertebrate single-lens eyes, but significantly larger fields of view with negligible distortion and spherical aberration, as well as high temporal resolution in a tiny package. Compound eyes are ideally suited for fast panoramic motion perception. Engineering a miniature artificial compound eye is challenging because it requires accurate alignment of photoreceptive and optical components on a curved surface. Here, we describe a unique design method for biomimetic compound eyes featuring a panoramic, undistorted field of view in a very thin package. The design consists of three planar layers of separately produced arrays, namely, a microlens array, a neuromorphic photodetector array, and a flexible printed circuit board that are stacked, cut, and curved to produce a mechanically flexible imager. Following this method, we have prototyped and characterized an artificial compound eye bearing a hemispherical field of view with embedded and programmable low-power signal processing, high temporal resolution, and local adaptation to illumination. The prototyped artificial compound eye possesses several characteristics similar to the eye of the fruit fly Drosophila and other arthropod species. This design method opens up additional vistas for a broad range of applications in which wide field motion detection is at a premium, such as collision-free navigation of terrestrial and aerospace vehicles, and for the experimental testing of insect vision theories.

  17. Curve Length Estimation using Vertix Chain Code Curve Length Estimation

    Directory of Open Access Journals (Sweden)

    Habibollah Haron

    2010-09-01

    Full Text Available Most of the applications in image analysis are based on Freeman chain code. In this paper, for the first time, vertex chain code (VCC proposed by Bribiesca is applied to improve length estimation of the 2D digitized curve. The chain code has some preferences such as stable in shifting, turning, mirroring movement of image and has normalized starting point. Due to the variety of length estimator methods, we focused on the three specific techniques. First, the way Bribiesca proposed which is based on counting links between vertices; second, based on maximum length digital straight segments (DSSs and lastly local metrics. The results of these length estimators with the real perimeter are compared. Results thus obtained exhibits thatlength estimation using VCC is nearest to the actual length.

  18. Prognostic and survival analysis of presbyopia: The healthy twin study

    Science.gov (United States)

    Lira, Adiyani; Sung, Joohon

    2015-12-01

    Presbyopia, a vision condition in which the eye loses its flexibility to focus on near objects, is part of ageing process which mostly perceptible in the early or mid 40s. It is well known that age is its major risk factor, while sex, alcohol, poor nutrition, ocular and systemic diseases are known as common risk factors. However, many other variables might influence the prognosis. Therefore in this paper we developed a prognostic model to estimate survival from presbyopia. 1645 participants which part of the Healthy Twin Study, a prospective cohort study that has recruited Korean adult twins and their family members based on a nation-wide registry at public health agencies since 2005, were collected and analyzed by univariate analysis as well as Cox proportional hazard model to reveal the prognostic factors for presbyopia while survival curves were calculated by Kaplan-Meier method. Besides age, sex, diabetes, and myopia; the proposed model shows that education level (especially engineering program) also contribute to the occurrence of presbyopia as well. Generally, at 47 years old, the chance of getting presbyopia becomes higher with the survival probability is less than 50%. Furthermore, our study shows that by stratifying the survival curve, MZ has shorter survival with average onset time about 45.8 compare to DZ and siblings with 47.5 years old. By providing factors that have more effects and mainly associate with presbyopia, we expect that we could help to design an intervention to control or delay its onset time.

  19. Bragg Curve, Biological Bragg Curve and Biological Issues in Space Radiation Protection with Shielding

    Science.gov (United States)

    Honglu, Wu; Cucinotta, F.A.; Durante, M.; Lin, Z.; Rusek, A.

    2006-01-01

    The space environment consists of a varying field of radiation particles including high-energy ions, with spacecraft shielding material providing the major protection to astronauts from harmful exposure. Unlike low-LET gamma or X-rays, the presence of shielding does not always reduce the radiation risks for energetic charged particle exposure. Since the dose delivered by the charged particle increases sharply as the particle approaches the end of its range, a position known as the Bragg peak, the Bragg curve does not necessarily represent the biological damage along the particle traversal since biological effects are influenced by the track structure of both primary and secondary particles. Therefore, the biological Bragg curve is dependent on the energy and the type of the primary particle, and may vary for different biological endpoints. To achieve a Bragg curve distribution, we exposed cells to energetic heavy ions with the beam geometry parallel to a monolayer of fibroblasts. Qualitative analyses of gamma-H2AX fluorescence, a known marker of DSBs, indicated increased clustering of DNA damage before the Bragg peak, enhanced homogenous distribution at the peak, and provided visual evidence of high linear energy transfer (LET) particle traversal of cells beyond the Bragg peak. A quantitative biological response curve generated for micronuclei (MN) induction across the Bragg curve did not reveal an increased yield of MN at the location of the Bragg peak. However, the ratio of mono-to bi-nucleated cells, which indicates inhibition in cell progression, increased at the Bragg peak location. These results, along with other biological concerns, show that space radiation protection with shielding can be a complicated issue.

  20. Spitzer Space Telescope Mid-IR Light Curves of Neptune

    CERN Document Server

    Stauffer, J R; Gizis, J E; Rebull, L M; Carey, S J; Krick, J; Ingalls, J G; Lowrance, P; Glaccum, W; Kirkpatrick, J D; Simon, A A; Wong, M H

    2016-01-01

    We have used the Spitzer Space Telescope in February 2016 to obtain high cadence, high signal-to-noise, 17-hour duration light curves of Neptune at 3.6 and 4.5 $\\mu$m. The light curve duration was chosen to correspond to the rotation period of Neptune. Both light curves are slowly varying with time, with full amplitudes of 1.1 mag at 3.6 $\\mu$m and 0.6 mag at 4.5 $\\mu$m. We have also extracted sparsely sampled 18-hour light curves of Neptune at W1 (3.4 $\\mu$m) and W2 (4.6 $\\mu$m) from the WISE/NEOWISE archive at six epochs in 2010-2015. These light curves all show similar shapes and amplitudes compared to the Spitzer light curves but with considerable variation from epoch to epoch. These amplitudes are much larger than those observed with Kepler/K2 in the visible (amplitude $\\sim$0.02 mag) or at 845 nm with the Hubble Space Telescope in 2015 and at 763 nm in 2016 (amplitude $\\sim$ 0.2 mag). We interpret the Spitzer and WISE light curves as arising entirely from reflected solar photons, from higher levels in N...

  1. Transition curves for highway geometric design

    CERN Document Server

    Kobryń, Andrzej

    2017-01-01

    This book provides concise descriptions of the various solutions of transition curves, which can be used in geometric design of roads and highways. It presents mathematical methods and curvature functions for defining transition curves. .

  2. Atlas of stress-strain curves

    CERN Document Server

    2002-01-01

    The Atlas of Stress-Strain Curves, Second Edition is substantially bigger in page dimensions, number of pages, and total number of curves than the previous edition. It contains over 1,400 curves, almost three times as many as in the 1987 edition. The curves are normalized in appearance to aid making comparisons among materials. All diagrams include metric (SI) units, and many also include U.S. customary units. All curves are captioned in a consistent format with valuable information including (as available) standard designation, the primary source of the curve, mechanical properties (including hardening exponent and strength coefficient), condition of sample, strain rate, test temperature, and alloy composition. Curve types include monotonic and cyclic stress-strain, isochronous stress-strain, and tangent modulus. Curves are logically arranged and indexed for fast retrieval of information. The book also includes an introduction that provides background information on methods of stress-strain determination, on...

  3. Curved Gabor Filters for Fingerprint Image Enhancement

    CERN Document Server

    Gottschlich, Carsten

    2011-01-01

    Gabor filters play an important role in many application areas for the enhancement of various types of images and the extraction of Gabor features. For the purpose of enhancing curved structures in noisy images, we introduce curved Gabor filters which locally adapt their shape to the direction of flow. These curved Gabor filters enable the choice of filter parameters which increase the smoothing power without creating artifacts in the enhanced image. In this paper, curved Gabor filters are applied to the curved ridge and valley structure of low-quality fingerprint images. First, we combine two orientation field estimation methods in order to obtain a more robust estimation for very noisy images. Next, curved regions are constructed by following the respective local orientation and they are used for estimating the local ridge frequency. Lastly, curved Gabor filters are defined based on curved regions and they are applied for the enhancement of low-quality fingerprint images. Experimental results on the FVC2004...

  4. Whitney's formulas for curves on surfaces

    CERN Document Server

    Burman, Yurii

    2009-01-01

    The classical Whitney formula relates the number of times an oriented plane curve cuts itself to its rotation number and the index of a base point. In this paper we generalize Whitney's formula to curves on an oriented punctured surface. To define analogs of the rotation number and the index of a base point of a curve, we fix an arbitrary vector field on the surface. Similar formulas are obtained for non-based curves.

  5. Bacterial streamers in curved microchannels

    Science.gov (United States)

    Rusconi, Roberto; Lecuyer, Sigolene; Guglielmini, Laura; Stone, Howard

    2009-11-01

    Biofilms, generally identified as microbial communities embedded in a self-produced matrix of extracellular polymeric substances, are involved in a wide variety of health-related problems ranging from implant-associated infections to disease transmissions and dental plaque. The usual picture of these bacterial films is that they grow and develop on surfaces. However, suspended biofilm structures, or streamers, have been found in natural environments (e.g., rivers, acid mines, hydrothermal hot springs) and are always suggested to stem from a turbulent flow. We report the formation of bacterial streamers in curved microfluidic channels. By using confocal laser microscopy we are able to directly image and characterize the spatial and temporal evolution of these filamentous structures. Such streamers, which always connect the inner corners of opposite sides of the channel, are always located in the middle plane. Numerical simulations of the flow provide evidences for an underlying hydrodynamic mechanism behind the formation of the streamers.

  6. Counting rational points on cubic curves

    Institute of Scientific and Technical Information of China (English)

    HEATH-BROWN; Roger; TESTA; Damiano

    2010-01-01

    We prove upper bounds for the number of rational points on non-singular cubic curves defined over the rationals.The bounds are uniform in the curve and involve the rank of the corresponding Jacobian.The method used in the proof is a combination of the "determinant method" with an m-descent on the curve.

  7. Optimal investment in learning-curve technologies

    NARCIS (Netherlands)

    Della Seta, M.; Gryglewicz, S.; Kort, P.M.

    2012-01-01

    We study optimal investment in technologies characterized by the learning curve. There are two investment patterns depending on the shape of the learning curve. If the learning process is slow, firms invest relatively late and on a larger scale. If the curve is steep, firms invest earlier and on a s

  8. A STUDY ON JIG DISTRIBUTION CURVE TRANSFORMATION

    Institute of Scientific and Technical Information of China (English)

    路迈西; 常大山; 郭珍旭

    1991-01-01

    An investigation of the errors resulted from distribution curve transformations using six different methods was made on the basis of 61 sets of jig performance test data from the coal preparation plants in China. The results indicate that minimum error occurred when distribution curves were transformed by keeping imperfection I constant. Generalized distribution curves are developed for jigs and their applications are discussed.

  9. The Bezout Number of Piecewise Algebraic Curves

    Institute of Scientific and Technical Information of China (English)

    Dian Xuan GONG; Ren Hong WANG

    2012-01-01

    Based on the discussion of the number of roots of univariate spline and the common zero points of two piecewise algebraic curves,a lower upbound of Bezout number of two piecewise algebraic curves on any given non-obtuse-angled triangulation is found.Bezout number of two piecewise algebraic curves on two different partitions is also discussed in this paper.

  10. Automated Blazar Light Curves Using Machine Learning

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, Spencer James [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-07-27

    This presentation describes a problem and methodology pertaining to automated blazar light curves. Namely, optical variability patterns for blazars require the construction of light curves and in order to generate the light curves, data must be filtered before processing to ensure quality.

  11. Sonoclot coagulation analysis: a useful tool to predict mortality in overt disseminated intravascular coagulation.

    Science.gov (United States)

    Wan, Peng; Yu, Min; Qian, Min; Tong, Huasheng; Su, Lei

    2016-01-01

    Disseminated intravascular coagulation (DIC) contributes to high mortality. The study was performed to investigate Sonoclot as a potential predictor of 30-day survival in overt DIC. This cohort included 237 consecutive critically ill patients with overt DIC, admitted to a 15-bed multidisciplinary ICU between July 2010 and July 2013. Hemostasis was analyzed with Sonoclot, including activated clotting time (ACT), clot rate, and platelet function, as well as routine clotting test at admission to the critical care center. Sonoclot variables differed in survivors and nonsurvivors. Mean ACT was prolonged (289.9 ± 200.5 vs. 194.8 ± 126.6 s; P < 0.001) and platelet function (1.2 ± 0.9 vs. 1.6 ± 1.2; P = 0.010) was reduced in nonsurvivors. The clot rate was not different. Cox proportional-hazard model showed that ACT and platelet function correlated independently with survival (P < 0.05). Kaplan-Meier survival curve analysis suggested that patients with one pathological Sonoclot findings have better outcome (P < 0.05). After ACT and platelet function were introduced, the receiver-operating characteristic area under the curve of model achieved 0.876 (P < 0.05), with a specificity of 82.6% and a sensitivity of 80.5% in prediction of 30-day survival by multivariate analyses. Our data suggest that the Sonoclot can predict mortality in critically ill patients with overt DIC.

  12. A simple sarcopenia screening test predicts future adverse events in patients with heart failure.

    Science.gov (United States)

    Onoue, Yoshiro; Izumiya, Yasuhiro; Hanatani, Shinsuke; Tanaka, Tomoko; Yamamura, Satoru; Kimura, Yuichi; Araki, Satoshi; Sakamoto, Kenji; Tsujita, Kenichi; Yamamoto, Eiichiro; Yamamuro, Megumi; Kojima, Sunao; Kaikita, Koichi; Hokimoto, Seiji

    2016-07-15

    Progressive loss of skeletal muscle termed "sarcopenia" is an independent risk factor for mortality in patients with cardiovascular diseases. A simple screening test that can identify sarcopenia using three variables (age, grip strength and calf circumference) was recently developed. We evaluated the clinical utility of this screening test in patients with heart failure (HF). HF patients were divided into the sarcopenia (n=82) and non-sarcopenia (n=37) groups based on the sarcopenia score. Circulating BNP and high-sensitive cardiac troponin T levels were significantly higher, and left ventricular ejection fraction was lower in the sarcopenia group than non-sarcopenia group. Kaplan-Meier curve showed that HF event-free survival rate was significantly lower in the sarcopenia group. Multivariate Cox proportional hazards analysis identified BNP (ln[BNP]) (hazard ratio [HR]: 1.58; 95% CI: 1.09-2.29, p=0.02), hs-CRP (ln[CRP]) (HR: 1.82; 95% CI: 1.23-2.68; psarcopenia score (HR: 1.03; 95% CI: 1.01-1.05, psarcopenia score to BNP levels increased an area under the curve for future HF events (sarcopenia score alone, 0.77; BNP alone, 0.82; combination, 0.89). The sarcopenia screening test can be used to predict future adverse events in patients with HF. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  13. Altered expression patterns of syndecan-1 and -2 predict biochemical recurrence in prostate cancer.

    Science.gov (United States)

    Ledezma, Rodrigo; Cifuentes, Federico; Gallegos, Iván; Fullá, Juan; Ossandon, Enrique; Castellon, Enrique A; Contreras, Héctor R

    2011-05-01

    The clinical features of prostate cancer do not provide an accurate determination of patients undergoing biochemical relapse and are therefore not suitable as indicators of prognosis for recurrence. New molecular markers are needed for proper pre-treatment risk stratification of patients. Our aim was to assess the value of altered expression of syndecan-1 and -2 as a marker for predicting biochemical relapse in patients with clinically localized prostate cancer treated by radical prostatectomy. The expression of syndecan-1 and -2 was examined by immunohistochemical staining in a series of 60 paraffin-embedded tissue samples from patients with localized prostate cancer. Ten specimens from patients with benign prostatic hyperplasia were used as non-malignant controls. Semiquantitative analysis was performed to evaluate the staining patterns. To investigate the prognostic value, Kaplan-Meier survival curves were performed and compared by a log-rank test. In benign samples, syndecan-1 was expressed in basal and secretory epithelial cells with basolateral membrane localisation, whereas syndecan-2 was expressed preferentially in basal cells. In prostate cancer samples, the expression patterns of both syndecans shifted to granular-cytoplasmic localisation. Survival analysis showed a significant difference (P < 0.05) between normal and altered expression of syndecan-1 and -2 in free prostate-specific antigen recurrence survival curves. These data suggest that the expression of syndecan-1 and -2 can be used as a prognostic marker for patients with clinically localized prostate cancer, improving the prostate-specific antigen recurrence risk stratification.

  14. Prognostic Impact of Pretreatment Plasma Fibrinogen in Patients with Locally Advanced Oral and Oropharyngeal Cancer.

    Directory of Open Access Journals (Sweden)

    Daniel Holzinger

    Full Text Available We aimed to determine the prognostic significance of pretreatment plasma fibrinigen in patients with oral and oropharyngeal squamous cell carcinoma (OOSCC.A cohort of 183 patients with locally advanced OOSCC receiving preoperative chemoradiotherapy was retrospectively examined. Using ROC curve analysis, a pretreatment plasma fibrinogen cutoff value of 447mg/dL was determined. The primary endpoints were overall survival and recurrence-free survival. A secondary endpoint was to determine whether pretreatment plasma fibrinogen could predict treatment response to neoadjuvant chemoradiotherapy. Cox regression models and Kaplan-Meier curves were used for survival analyses.Seventy-one patients had an elevated pretreatment plasma fibrinogen (fibrinogen >447mg/dL. Patients with high fibrinogen showed significantly higher pathologic stages after neoadjuvant treatment than those with low fibrinogen (p = 0.037. In univariate analysis, elevated fibrinogen was associated with poor overall survival (p = 0.005 and recurrence-free survival (p = 0.008 Multivariate analysis revealed that elevated fibrinogen remained an independent risk factor for death (hazard ratio 1.78, 95% CI 1.09-2.90, p = 0.021 and relapse (hazard ratio 1.78, 95% CI 1.11-2.86, p = 0.016.Elevated pretreatment plasma fibrinogen is associated with lack of response to neoadjuvant chemoradiotherapy and reduced OS and RFS in patients with OOSCC. Thus, plasma fibrinogen may emerge as a novel prognostic indicator and a potential therapeutic target in OOSCC.

  15. Altered expression patterns of syndecan-1 and -2 predict biochemical recurrence in prostate cancer

    Institute of Scientific and Technical Information of China (English)

    Rodrigo Ledezma; Federico Cifuentes; Iván Gallegos; Juan Fullá; Enrique Ossandon; Enrique A Castellon; Héctor R Contreras

    2011-01-01

    The clinical features of prostate cancer do not provide an accurate determination of patients undergoing biochemical relapse and are therefore not suitable as indicators of prognosis for recurrence. New molecular markers are needed for proper pre-treatment risk stratification of patients. Our aim was to assess the value of altered expression of syndecan-1 and -2 as a marker for predicting biochemical relapse in patients with clinically localized prostate cancer treated by radical prostatectomy. The expression of syndecan-1 and -2 was examined by immunohistochemical staining in a series of 60 paraffin-embedded tissue samples from patients with localized prostate cancer. Ten specimens from patients with benign prostatic hyperplasia were used as non-malignant controls. Semiquantitative analysis was performed to evaluate the staining patterns. To investigate the prognostic value, Kaplan-Meier survival curves were performed and compared by a log-rank test. In benign samples, syndecan-1 was expressed in basal and secretory epithelial cells with basolateral membrane localisation, whereas syndecan-2 was expressed preferentially in basal cells. In prostate cancer samples, the expression patterns of both syndecans shifted to granular-cytoplasmic localisation. Survival analysis showed a significant difference (P<0.05) between normal and altered expression of syndecan-1 and -2 in free prostate-specific antigen recurrence survival curves. These data suggest that the expression of syndecan-1 and -2 can be used as a prognostic marker for patients with clinically localized prostate cancer, improving the prostate-specific antigen recurrence risk stratification.

  16. AKLSQF - LEAST SQUARES CURVE FITTING

    Science.gov (United States)

    Kantak, A. V.

    1994-01-01

    The Least Squares Curve Fitting program, AKLSQF, computes the polynomial which will least square fit uniformly spaced data easily and efficiently. The program allows the user to specify the tolerable least squares error in the fitting or allows the user to specify the polynomial degree. In both cases AKLSQF returns the polynomial and the actual least squares fit error incurred in the operation. The data may be supplied to the routine either by direct keyboard entry or via a file. AKLSQF produces the least squares polynomial in two steps. First, the data points are least squares fitted using the orthogonal factorial polynomials. The result is then reduced to a regular polynomial using Sterling numbers of the first kind. If an error tolerance is specified, the program starts with a polynomial of degree 1 and computes the least squares fit error. The degree of the polynomial used for fitting is then increased successively until the error criterion specified by the user is met. At every step the polynomial as well as the least squares fitting error is printed to the screen. In general, the program can produce a curve fitting up to a 100 degree polynomial. All computations in the program are carried out under Double Precision format for real numbers and under long integer format for integers to provide the maximum accuracy possible. AKLSQF was written for an IBM PC X/AT or compatible using Microsoft's Quick Basic compiler. It has been implemented under DOS 3.2.1 using 23K of RAM. AKLSQF was developed in 1989.

  17. Caloric curve of star clusters.

    Science.gov (United States)

    Casetti, Lapo; Nardini, Cesare

    2012-06-01

    Self-gravitating systems, such as globular clusters or elliptical galaxies, are the prototypes of many-body systems with long-range interactions, and should be the natural arena in which to test theoretical predictions on the statistical behavior of long-range-interacting systems. Systems of classical self-gravitating particles can be studied with the standard tools of equilibrium statistical mechanics, provided the potential is regularized at small length scales and the system is confined in a box. The confinement condition looks rather unphysical in general, so that it is natural to ask whether what we learn with these studies is relevant to real self-gravitating systems. In order to provide an answer to this question, we consider a basic, simple, yet effective model of globular clusters: the King model. This model describes a self-consistently confined system, without the need of any external box, but the stationary state is a nonthermal one. In particular, we consider the King model with a short-distance cutoff on the interactions, and we discuss how such a cutoff affects the caloric curve, i.e., the relation between temperature and energy. We find that the cutoff stabilizes a low-energy phase, which is absent in the King model without cutoff; the caloric curve of the model with cutoff turns out to be very similar to that of previously studied confined and regularized models, but for the absence of a high-energy gaslike phase. We briefly discuss the possible phenomenological as well as theoretical implications of these results.

  18. Study on Luster of Fabrics with Goniophotometric Curves

    Institute of Scientific and Technical Information of China (English)

    石风俊; 严灏景

    2001-01-01

    The distribution of the light reflected from various fabric surfaces was studied. A series of samples of different fibers, weaves and colors were investigated. The experiments show that the goniophotometric curves of fabrics change with constituent fibers, weave, dyeing and finishing, and experimental condition.The goniophotometric curves for fabrics of same kind with different colors are same in general shape, and the reflectance or the height of the curves are changed to the extent of that they are in proportion with the brightness or the tristimulus value Y of the samples. The goniophotometric curve also varies in form when the incident angle is changed. Discussion and explanation for the above mentioned are given. Luster of the samples was calculated with methods suggested by different indexing systems.

  19. Zeta Functions for Elliptic Curves I. Counting Bundles

    CERN Document Server

    Weng, Lin

    2012-01-01

    To count bundles on curves, we study zetas of elliptic curves and their zeros. There are two types, i.e., the pure non-abelian zetas defined using moduli spaces of semi-stable bundles, and the group zetas defined for special linear groups. In lower ranks, we show that these two types of zetas coincide and satisfy the Riemann Hypothesis. For general cases, exposed is an intrinsic relation on automorphism groups of semi-stable bundles over elliptic curves, the so-called counting miracle. All this, together with Harder-Narasimhan, Desale-Ramanan and Zagier's result, gives an effective way to count semi-stable bundles on elliptic curves not only in terms of automorphism groups but more essentially in terms of their $h^0$'s. Distributions of zeros of high rank zetas are also discussed.

  20. Dynamic constitutive model for soils considering asymmetry of skeleton curve

    Institute of Scientific and Technical Information of China (English)

    Guoxing Chen; Hua Pan; Hui Long; Xiaojun Li

    2013-01-01

    Based on the asymmetric characteristic of skeleton curve obtained from dynamic tests on soils, a func-tion with double asymptotes is proposed for describing the dynamic constitutive relations of soils. The hysteresis loops observed during unloading and reloading show the same form as the skeleton curve and are constructed by taking the ultimate stress as the corresponding asymptote. The coefficient of initial unloading modulus is used to ensure that the constructed hysteresis loop fits well with the experimental data. Then, a new dynamic constitutive model considering the asymmetry of skeleton curve is elaborated. The verification tests on saturated Nanjing fine sand are performed using a hollow cylinder apparatus to verify the applicability of the UD model. It is found that the predicted curves by the UD model agree well with the test data.

  1. The symmetric square of a curve and the Petri map

    CERN Document Server

    Bruno, A

    2011-01-01

    Let $\\M_g$ be the course moduli space of complex projective nonsingular curves of genus $g$. We prove that when the Brill-Noether number $\\rho(g,1,n)$ is non-negative the Petri locus $P^1_{g,n}\\subset \\M_g$ has a divisorial component whose closure has a non-empty intersection with $\\Delta_0$. In order to prove the result we show that the scheme $G^1_n(\\Gamma)$ that parametrizes degree $n$ pencils on a curve $\\Gamma$ is isomorphic to a component of the Hilbert scheme parametrizing certain curves on the symmetric square $\\Gamma_2$ of $\\Gamma$ and we study the properties of such a family of curves.

  2. Leptogenesis from loop effects in curved spacetime

    CERN Document Server

    McDonald, Jamie I

    2015-01-01

    We describe a new mechanism -- radiatively-induced gravitational leptogenesis -- for generating the matter-antimatter asymmetry of the Universe. We show how quantum loop effects in C and CP violating theories cause matter and antimatter to propagate differently in the presence of gravity, and prove this is forbidden in flat space by CPT and translation symmetry. This generates a curvature-dependent chemical potential for leptons, allowing a matter-antimatter asymmetry to be generated in thermal equilibrium in the early Universe. The time-dependent dynamics necessary for leptogenesis is provided by the interaction of the virtual self-energy cloud of the leptons with the expanding curved spacetime background, which violates the strong equivalence principle and allows a distinction between matter and antimatter. We show here how this mechanism is realised in a particular BSM theory, the see-saw model, where the quantum loops involve the heavy sterile neutrinos responsible for light neutrino masses. We demonstrat...

  3. Maturation curves of sweet sorghum genotypes

    Directory of Open Access Journals (Sweden)

    Renan Silva e Souza

    2016-02-01

    Full Text Available ABSTRACT Sweet sorghum [Sorghum bicolor (L. Moench] stands out as a complementary crop to sugarcane Saccharum spp. for the production of ethanol, since it has juicy stems with directly fermentable sugars. Due to this fact, there is a need for the analysis of sweet sorghum properties in order to meet the agro-industry demand. This work aimed to develop and study the maturation curves of seven sweet sorghum cultivars in ten harvest dates. The results showed a significant difference between cultivars and harvest dates for all parameters analysed (p≤0.01. Regarding the sugar content, the cultivars BRS508, XBWS80147 and CMSX629 showed the highest means for the total reducing sugars (TRS and recoverable sugar (RS. In the production of ethanol per tonne of biomass (EP, the cultivars BRS508 and CMSX629 presented the best results.

  4. Gaudin subalgebras and stable rational curves

    CERN Document Server

    Aguirre, Leonardo; Veselov, Alexander P

    2010-01-01

    Gaudin subalgebras are abelian Lie subalgebras of maximal dimension spanned by generators of the Kohno-Drinfeld Lie algebra t_n. We show that Gaudin subalgebras form a variety isomorphic to the moduli space of stable curves of genus zero with n+1 marked points. In particular, this gives an embedding of the moduli space in a Grassmannian of (n-1)-planes in an n(n-1)/2-dimensional space. We show that the sheaf of Gaudin subalgebras over the moduli space is isomorphic to a sheaf of twisted first order differential operators. For each representation of the Kohno--Drinfeld Lie algebra with fixed central character, we obtain a sheaf of commutative algebras whose spectrum is a coisotropic subscheme of a twisted version of the logarithmic cotangent bundle of the moduli space.

  5. DECIPHERING THERMAL PHASE CURVES OF DRY, TIDALLY LOCKED TERRESTRIAL PLANETS

    Energy Technology Data Exchange (ETDEWEB)

    Koll, Daniel D. B.; Abbot, Dorian S., E-mail: dkoll@uchicago.edu [Department of the Geophysical Sciences, University of Chicago, Chicago, IL 60637 (United States)

    2015-03-20

    Next-generation space telescopes will allow us to characterize terrestrial exoplanets. To do so effectively it will be crucial to make use of all available data. We investigate which atmospheric properties can, and cannot, be inferred from the broadband thermal phase curve of a dry and tidally locked terrestrial planet. First, we use dimensional analysis to show that phase curves are controlled by six nondimensional parameters. Second, we use an idealized general circulation model to explore the relative sensitivity of phase curves to these parameters. We find that the feature of phase curves most sensitive to atmospheric parameters is the peak-to-trough amplitude. Moreover, except for hot and rapidly rotating planets, the phase amplitude is primarily sensitive to only two nondimensional parameters: (1) the ratio of dynamical to radiative timescales and (2) the longwave optical depth at the surface. As an application of this technique, we show how phase curve measurements can be combined with transit or emission spectroscopy to yield a new constraint for the surface pressure and atmospheric mass of terrestrial planets. We estimate that a single broadband phase curve, measured over half an orbit with the James Webb Space Telescope, could meaningfully constrain the atmospheric mass of a nearby super-Earth. Such constraints will be important for studying the atmospheric evolution of terrestrial exoplanets as well as characterizing the surface conditions on potentially habitable planets.

  6. A capture-recapture survival analysis model for radio-tagged animals

    Science.gov (United States)

    Pollock, K.H.; Bunck, C.M.; Winterstein, S.R.; Chen, C.-L.; North, P.M.; Nichols, J.D.

    1995-01-01

    In recent years, survival analysis of radio-tagged animals has developed using methods based on the Kaplan-Meier method used in medical and engineering applications (Pollock et al., 1989a,b). An important assumption of this approach is that all tagged animals with a functioning radio can be relocated at each sampling time with probability 1. This assumption may not always be reasonable in practice. In this paper, we show how a general capture-recapture model can be derived which allows for some probability (less than one) for animals to be relocated. This model is not simply a Jolly-Seber model because it is possible to relocate both dead and live animals, unlike when traditional tagging is used. The model can also be viewed as a generalization of the Kaplan-Meier procedure, thus linking the Jolly-Seber and Kaplan-Meier approaches to survival estimation. We present maximum likelihood estimators and discuss testing between submodels. We also discuss model assumptions and their validity in practice. An example is presented based on canvasback data collected by G. M. Haramis of Patuxent Wildlife Research Center, Laurel, Maryland, USA.

  7. Estimation of exposure distribution adjusting for association between exposure level and detection limit.

    Science.gov (United States)

    Yang, Yuchen; Shelton, Brent J; Tucker, Thomas T; Li, Li; Kryscio, Richard; Chen, Li

    2017-08-15

    In environmental exposure studies, it is common to observe a portion of exposure measurements to fall below experimentally determined detection limits (DLs). The reverse Kaplan-Meier estimator, which mimics the well-known Kaplan-Meier estimator for right-censored survival data with the scale reversed, has been recommended for estimating the exposure distribution for the data subject to DLs because it does not require any distributional assumption. However, the reverse Kaplan-Meier estimator requires the independence assumption between the exposure level and DL and can lead to biased results when this assumption is violated. We propose a kernel-smoothed nonparametric estimator for the exposure distribution without imposing any independence assumption between the exposure level and DL. We show that the proposed estimator is consistent and asymptotically normal. Simulation studies demonstrate that the proposed estimator performs well in practical situations. A colon cancer study is provided for illustration. Copyright © 2017 John Wiley & Sons, Ltd. Copyright © 2017 John Wiley & Sons, Ltd.

  8. Method of construction spatial transition curve

    Directory of Open Access Journals (Sweden)

    S.V. Didanov

    2013-04-01

    Full Text Available Purpose. The movement of rail transport (speed rolling stock, traffic safety, etc. is largely dependent on the quality of the track. In this case, a special role is the transition curve, which ensures smooth insertion of the transition from linear to circular section of road. The article deals with modeling of spatial transition curve based on the parabolic distribution of the curvature and torsion. This is a continuation of research conducted by the authors regarding the spatial modeling of curved contours. Methodology. Construction of the spatial transition curve is numerical methods for solving nonlinear integral equations, where the initial data are taken coordinate the starting and ending points of the curve of the future, and the inclination of the tangent and the deviation of the curve from the tangent plane at these points. System solutions for the numerical method are the partial derivatives of the equations of the unknown parameters of the law of change of torsion and length of the transition curve. Findings. The parametric equations of the spatial transition curve are calculated by finding the unknown coefficients of the parabolic distribution of the curvature and torsion, as well as the spatial length of the transition curve. Originality. A method for constructing the spatial transition curve is devised, and based on this software geometric modeling spatial transition curves of railway track with specified deviations of the curve from the tangent plane. Practical value. The resulting curve can be applied in any sector of the economy, where it is necessary to ensure a smooth transition from linear to circular section of the curved space bypass. An example is the transition curve in the construction of the railway line, road, pipe, profile, flat section of the working blades of the turbine and compressor, the ship, plane, car, etc.

  9. Cubic Curves, Finite Geometry and Cryptography

    CERN Document Server

    Bruen, A A; Wehlau, D L

    2011-01-01

    Some geometry on non-singular cubic curves, mainly over finite fields, is surveyed. Such a curve has 9,3,1 or 0 points of inflexion, and cubic curves are classified accordingly. The group structure and the possible numbers of rational points are also surveyed. A possible strengthening of the security of elliptic curve cryptography is proposed using a `shared secret' related to the group law. Cubic curves are also used in a new way to construct sets of points having various combinatorial and geometric properties that are of particular interest in finite Desarguesian planes.

  10. On Self-growing Modeling for Curves

    Institute of Scientific and Technical Information of China (English)

    HUANG Dong-zhao; ZHU Zhi-hong; ZHOU Hui-cheng; SHI Han-min

    2008-01-01

    This paperpresents a novel curoe modeling method based on controlling rules of the shaping technique.The method describes the curve based on steplength and turning angle,and the characteristics of the curve near a point.Then it introduces the process to extract" growing-rules"for 2D and 3D curves described by familiar analytical expressions and curvature-torsion expressions.Examples of selfgrowing modeling for familiar analytical curves are presented.New curves are obtained by designing the grow-rules;corresponding examples are also presented.

  11. Koch Curves: Rewriting System, Geometry and Application

    Directory of Open Access Journals (Sweden)

    Mamta Rani

    2011-01-01

    Full Text Available Problem statement: Recently, new Koch curves have been generated by dividing the initiator into three unequal parts. There is no formal rewriting system to generate such kind of curves. Approach: It is required to measure the new changed geometrical properties. Generalized rewriting systems for the new Koch curves have been developed. Results: New formulas have been given to measure their geometrical properties. Conclusion/Recommendations: The geometrical properties of new Koch curves make them more suitable as antennas in wireless communication than the conventional Koch curve.

  12. Focal Conic Flower Textures at Curved Interfaces

    Directory of Open Access Journals (Sweden)

    Daniel A. Beller

    2013-12-01

    Full Text Available Focal conic domains (FCDs in smectic-A liquid crystals have drawn much attention, both for their exquisitely structured internal form and for their ability to direct the assembly of micromaterials and nanomaterials in a variety of patterns. A key to directing FCD assembly is control over the eccentricity of the domain. Here, we demonstrate a new paradigm for creating spatially varying FCD eccentricity by confining a hybrid-aligned smectic with curved interfaces. In particular, we manipulate interface behavior with colloidal particles in order to experimentally produce two examples of what has recently been dubbed the flower texture [C. Meyer et al., Focal Conic Stacking in Smectic A Liquid Crystals: Smectic Flower and Apollonius Tiling, Materials 2, 499, 2009MATEG91996-194410.3390/ma2020499], where the focal hyperbolæ diverge radially outward from the center of the texture, rather than inward as in the canonical éventail or fan texture. We explain how this unconventional assembly can arise from appropriately curved interfaces. Finally, we present a model for this system that applies the law of corresponding cones, showing how FCDs may be embedded smoothly within a “background texture” of large FCDs and concentric spherical layers, in a manner consistent with the qualitative features of the smectic flower. Such understanding could potentially lead to disruptive liquid-crystal technologies beyond displays, including patterning, smart surfaces, microlens arrays, sensors, and nanomanufacturing.

  13. Accurate determination of characteristic relative permeability curves

    Science.gov (United States)

    Krause, Michael H.; Benson, Sally M.

    2015-09-01

    A recently developed technique to accurately characterize sub-core scale heterogeneity is applied to investigate the factors responsible for flowrate-dependent effective relative permeability curves measured on core samples in the laboratory. The dependency of laboratory measured relative permeability on flowrate has long been both supported and challenged by a number of investigators. Studies have shown that this apparent flowrate dependency is a result of both sub-core scale heterogeneity and outlet boundary effects. However this has only been demonstrated numerically for highly simplified models of porous media. In this paper, flowrate dependency of effective relative permeability is demonstrated using two rock cores, a Berea Sandstone and a heterogeneous sandstone from the Otway Basin Pilot Project in Australia. Numerical simulations of steady-state coreflooding experiments are conducted at a number of injection rates using a single set of input characteristic relative permeability curves. Effective relative permeability is then calculated from the simulation data using standard interpretation methods for calculating relative permeability from steady-state tests. Results show that simplified approaches may be used to determine flowrate-independent characteristic relative permeability provided flow rate is sufficiently high, and the core heterogeneity is relatively low. It is also shown that characteristic relative permeability can be determined at any typical flowrate, and even for geologically complex models, when using accurate three-dimensional models.

  14. Prognostic value of {sup 18}F-DOPA PET/CT at the time of recurrence in patients affected by neuroblastoma

    Energy Technology Data Exchange (ETDEWEB)

    Piccardo, Arnoldo [Galliera Hospital, Nuclear Medicine Unit, Genoa (Italy); E.O. Ospedali Galliera, Department of Nuclear Medicine, Genoa (Italy); Puntoni, Matteo [Galliera Hospital, Clinical Trial Research Unit, Genoa (Italy); Lopci, Egesta; Fanti, Stefano [Sant' Orsola-Malpighi Hospital, Nuclear Medicine Unit, Bologna (Italy); Conte, Massimo; Sorrentino, Stefania; Garaventa, Alberto [G. Gaslini Children' s Hospital, Department of Hematology-Oncology, Genoa (Italy); Foppiani, Luca [Galliera Hospital, Internal Medicine, Genoa (Italy); Morana, Giovanni [G. Gaslini Children' s Hospital, Department of Pathology and Radiology, Genoa (Italy); Naseri, Mehrdad; Villavecchia, Giampiero [Galliera Hospital, Nuclear Medicine Unit, Genoa (Italy); Cistaro, Angelina [IRMET, PET Centre, Turin (Italy)

    2014-06-15

    The aim of this study was to investigate the relationship between {sup 123}I-metaiodobenzylguanidine (MIBG) scan semi-quantification and a new {sup 18}F-DOPA positron emission tomography (PET)/CT score in patients with suspected or documented neuroblastoma (NB) relapse and to assess the association between these two parameters and progression-free survival (PFS)/overall survival (OS). We analysed 24 NB patients who had undergone {sup 123}I-MIBG and {sup 18}F-DOPA PET/CT scans at the time of suspected relapse, after applying a proper scoring system for each scan. In time-to-event analyses, the score distributions were regarded as continuous and were categorized in tertiles and medians. We used Kaplan-Meier curves and Cox proportional hazard models for PFS and OS in order to estimate the independent prognostic impact of {sup 123}I-MIBG and {sup 18}F-DOPA PET/CT scans. The {sup 123}I-MIBG and {sup 18}F-DOPA scores were highly and positively correlated (Spearman's rho = 0.8, p < 0.001). Over a median follow-up of 14 months (range 6-82), 12 cases of disease progression and 6 deaths occurred. Multivariate Cox models showed a higher risk of disease progression [hazard ratio (HR) 17.0, 95 % confidence interval (CI) 2.7-109] in NB patients with {sup 123}I-MIBG score > 3 (3rd tertile) and an even higher risk (HR:37.2, 95 % CI 2.4-574) in those with {sup 18}F-DOPA whole-body metabolic burden (WBMB) >7.5 (median), after adjustment for all main clinical/pathological factors considered. Kaplan-Meier analyses showed a significant association with OS (log-rank p = 0.01 and p = 0.03 for {sup 123}I-MIBG and {sup 18}F-DOPA WBMB, respectively). Our results confirm the good agreement between {sup 18}F-DOPA PET/CT and {sup 123}I-MIBG scan in patients affected by NB relapse. In time-to-event analyses, {sup 123}I-MIBG scan and {sup 18}F-DOPA PET/CT scores were independently and significantly associated with disease progression. (orig.)

  15. Relationship between LAPTM4B Gene Polymorphism and Prognosis of Patients following Tumor Resection for Colorectal and Esophageal Cancers.

    Science.gov (United States)

    Cheng, Xiaojing; Tian, Xiuyun; Wu, Xiaojiang; Xing, Xiaofang; Du, Hong; Zhou, Chunlian; Zhang, Qingyun; Hao, Chunyi; Wen, Xianzi; Ji, Jiafu

    2016-01-01

    Lysosome-associated transmembrane-4 beta (LAPTM4B) is an oncogene that participates tumorgenesis in a variety of human solid tumors, and it has two alleles named as LAPTM4B*1 and *2. The present study aimed to identify the association of LAPTM4B genotype with clinicopathological features and prognosis in colorectal and esophageal cancer patients. Genotypes of LAPTM4B were determined by PCR in 167 colon cancer cases (72 patients in a discovery cohort and 95 patients in a testing cohort), 160 rectal cancer cases and 164 esophageal cancer cases. Association between the LAPTM4B gene polymorphism and clinicopathological variables was calculated by Chi-square test or Fisher's exact test. Patient survival differences were calculated by the Kaplan-Meier method. Prognostic factors were determined with Log-rank test and Cox regression model. LAPTM4B *1/1 was more frequently detected in colon cancer patients with lymph node metastasis and TNM III+IV stages in total colon cancer (discovery + testing cohorts). LAPTM4B *2/2 decreased in recurrent patients in total colon cancer patients (P = 0.045). Kaplan-Meier survival curves and Log-rank test showed that LAPTM4B*1 was correlated with shorter overall survival (OS) in discovery and testing cohorts of colon cancer (P = 0.0254 and 0.0292, respectively), but not in rectal and esophageal cancer cases (P = 0.7669 and 0.9356, respectively). Multivariate analysis showed that LAPTM4B genotype was an independent prognostic factor for OS in total colon cancer [P = 0.004, hazard ratio (HR) = 0.432; 95% confidence interval (CI) = 0.243-0.768], but not in rectal and esophageal cancers (P = 0.791, HR = 1.073, 95% CI = 0.638-1.804 and 0.998, HR = 1.000, 95% CI = 0.663-1.530, respectively). These findings suggested that LAPTM4B allele *1 was a risk factor associated with poor prognosis in patients with colon cancer, but not in patients with rectal or esophageal cancers. LAPTM4B genotype status might be a useful prognostic indicator for patients

  16. Relationship between LAPTM4B Gene Polymorphism and Prognosis of Patients following Tumor Resection for Colorectal and Esophageal Cancers.

    Directory of Open Access Journals (Sweden)

    Xiaojing Cheng

    Full Text Available Lysosome-associated transmembrane-4 beta (LAPTM4B is an oncogene that participates tumorgenesis in a variety of human solid tumors, and it has two alleles named as LAPTM4B*1 and *2. The present study aimed to identify the association of LAPTM4B genotype with clinicopathological features and prognosis in colorectal and esophageal cancer patients.Genotypes of LAPTM4B were determined by PCR in 167 colon cancer cases (72 patients in a discovery cohort and 95 patients in a testing cohort, 160 rectal cancer cases and 164 esophageal cancer cases. Association between the LAPTM4B gene polymorphism and clinicopathological variables was calculated by Chi-square test or Fisher's exact test. Patient survival differences were calculated by the Kaplan-Meier method. Prognostic factors were determined with Log-rank test and Cox regression model.LAPTM4B *1/1 was more frequently detected in colon cancer patients with lymph node metastasis and TNM III+IV stages in total colon cancer (discovery + testing cohorts. LAPTM4B *2/2 decreased in recurrent patients in total colon cancer patients (P = 0.045. Kaplan-Meier survival curves and Log-rank test showed that LAPTM4B*1 was correlated with shorter overall survival (OS in discovery and testing cohorts of colon cancer (P = 0.0254 and 0.0292, respectively, but not in rectal and esophageal cancer cases (P = 0.7669 and 0.9356, respectively. Multivariate analysis showed that LAPTM4B genotype was an independent prognostic factor for OS in total colon cancer [P = 0.004, hazard ratio (HR = 0.432; 95% confidence interval (CI = 0.243-0.768], but not in rectal and esophageal cancers (P = 0.791, HR = 1.073, 95% CI = 0.638-1.804 and 0.998, HR = 1.000, 95% CI = 0.663-1.530, respectively.These findings suggested that LAPTM4B allele *1 was a risk factor associated with poor prognosis in patients with colon cancer, but not in patients with rectal or esophageal cancers. LAPTM4B genotype status might be a useful prognostic indicator for

  17. Relationship between LAPTM4B Gene Polymorphism and Prognosis of Patients following Tumor Resection for Colorectal and Esophageal Cancers

    Science.gov (United States)

    Xing, Xiaofang; Du, Hong; Zhou, Chunlian; Zhang, Qingyun; Hao, Chunyi; Wen, Xianzi; Ji, Jiafu

    2016-01-01

    Background Lysosome-associated transmembrane-4 beta (LAPTM4B) is an oncogene that participates tumorgenesis in a variety of human solid tumors, and it has two alleles named as LAPTM4B*1 and *2. The present study aimed to identify the association of LAPTM4B genotype with clinicopathological features and prognosis in colorectal and esophageal cancer patients. Method Genotypes of LAPTM4B were determined by PCR in 167 colon cancer cases (72 patients in a discovery cohort and 95 patients in a testing cohort), 160 rectal cancer cases and 164 esophageal cancer cases. Association between the LAPTM4B gene polymorphism and clinicopathological variables was calculated by Chi-square test or Fisher’s exact test. Patient survival differences were calculated by the Kaplan-Meier method. Prognostic factors were determined with Log-rank test and Cox regression model. Results LAPTM4B *1/1 was more frequently detected in colon cancer patients with lymph node metastasis and TNM III+IV stages in total colon cancer (discovery + testing cohorts). LAPTM4B *2/2 decreased in recurrent patients in total colon cancer patients (P = 0.045). Kaplan-Meier survival curves and Log-rank test showed that LAPTM4B*1 was correlated with shorter overall survival (OS) in discovery and testing cohorts of colon cancer (P = 0.0254 and 0.0292, respectively), but not in rectal and esophageal cancer cases (P = 0.7669 and 0.9356, respectively). Multivariate analysis showed that LAPTM4B genotype was an independent prognostic factor for OS in total colon cancer [P = 0.004, hazard ratio (HR) = 0.432; 95% confidence interval (CI) = 0.243–0.768], but not in rectal and esophageal cancers (P = 0.791, HR = 1.073, 95% CI = 0.638–1.804 and 0.998, HR = 1.000, 95% CI = 0.663–1.530, respectively). Conclusion These findings suggested that LAPTM4B allele *1 was a risk factor associated with poor prognosis in patients with colon cancer, but not in patients with rectal or esophageal cancers. LAPTM4B genotype status might

  18. A two-year follow-up for Chinese patients with abdominal aortic aneurysm undergoing open/endovascular repair

    Institute of Scientific and Technical Information of China (English)

    Sun Tao; Zhang Hongju; Cheng Yutong; Wang Su; Tao Ying; Zhang Donghua; Huang Ji

    2014-01-01

    Background A number of studies have demonstrated the rates of overall and aneurysm-related mortality and morbidity in Western populations.The cardiovascular risk factors influencing postoperative outcome have been also reported.Until recently,little has been known about the prognosis in this patient cohort in the Chinese population.We evaluated the independent predictors of mortality and morbidity in abdominal aortic aneurysm (AAA) patients undergoing elective surgical treatment and emphasized whether the coronary artery revascularization could have any effect on the overall mortality and morbidity in patients following the current guideline recommendation.Methods A total of 386 patients (174 women) undergoing surgery in Beijing Anzhen Hospital from January 2008 to June 2010 were enrolled (mean age (70.6±10.5) years).Kaplan-Meier curves were constructed to compare the mortality and morbidity of AAA patients with coronary artery revascularization and those without.A Cox proportional hazards model was constructed to identify clinical factors associated with two-year outcomes.The primary outcomes were death from any cause,the pre-specified morbidity was re-hospitalization for pulmonary conditions,congestive heart failure,angina,ischemic/hemorrhagic stroke.Results During the two-year follow-up,34 patients died and 65 experienced re-hospitalization with pulmonary conditions,congestive heart failure,angina,or ischemic/hemorrhagic stroke.Kaplan-Meier survival analysis showed that the AAA patients with cardiac revascularization had no higher incidence of overall mortality and major morbidity than those without (log-rank test P=0.35 and P=0.40,respectively).Cox proportional hazards regression analysis showed that level of low-density lipoprotein (HR,4.06; 95% CI:1.19-18.7,P=0.027) and AAA size (HR,2.18; 95% CI:1.28-11.65,P=0.036) were independently associated with the incidence of overall mortality.Long-term use of angiotensin converting enzyme inhibitors

  19. Flow Investigation inside A Curved Square Duct

    Directory of Open Access Journals (Sweden)

    Dipyaman Gangopadhyay

    2017-05-01

    Full Text Available This paper presents the results of an experimental work with measurement of wall static pressure of 90°C shaped Curved duct. The test duct is made up of transparent perspex sheets to facilitate the flow visualization study. The duct has an inlet to exit area ratio of 1.0 with centerline distance of 750 mm. The inlet aspect ratio of the test duct has been fixed at 1.0. The velocities for the proposed investigations are to be measured by using a Pitot tube.Wall pressures are measured with the help of an inclinedmanometer with the inclination of 35°. The manometer had two tubes emanating from it: one left open to the atmosphere and the other connected to the steel pipes attached to the four walls of the curved duct. The difference in the readings helped us calculate the static pressure and thereby the normalized pressure. Wall pressure distribution along the curved and parallel walls of the duct at 0°, 22.5°, 45°, 67.5° and 90° measuring sections was measured. All the experimental data has been processed by an Intel i3 CPU, 3 GB RAM PC and analyzed to give the distribution of static pressure in the square duct.The main purpose of this investigation is to show the development of secondary flow which happens when the flow takes place through the bend in the curvature. This secondary flow arises as a result of a centrifugal force acting when the flow moves through the bend. The investigation is carried out at three different velocities 20 m/s, 40 m/s and 60 m/s. The distribution of normalized pressure which is the ratio of static pressure to the dynamic pressure is mapped and shown in the form of contours by using the software package SURFER.The trend of wall static pressure development on the walls of C shaped duct shows that as the flow proceeds towards the curvature, there exists a high pressure gradient between the outside face and inside face due the centrifugal force acting along the curvature. This shows the bulk shifting of flow towards

  20. Clinicopathological, therapeutic and prognostic features of the triple-negative tumors in moroccan breast cancer patients (experience of Hassan II university hospital in Fez

    Directory of Open Access Journals (Sweden)

    Akasbi Yousra

    2011-11-01

    Full Text Available Abstract Introduction Triple-negative breast cancer (TNBC is defined as a group of breast carcinomas that are negative for expression of hormone receptors (ER, PR and Her2, we can distinguish between two groups: basal-like (ER-, PR-, Her2-, cytokeratin (CK 5/6+ and/or Her1+ and unclassified subtype (ER-, PR-, Her2-, Her1- and CK5/6-. The aim of this study is to determine the clinicopathological, histological, therapeutic and prognostic features associated with this type of breast cancer. Methods This is a retrospective study of 366 female breast cancer patients, diagnosed between January 2007 and June 2010 at the Department of Pathology. Epidemiological, clinical, histological, therapeutic and evolutive data were analyzed. OS and DFS rates were estimated by Kaplan-Meier analysis and a log-rank test to estimate outcome. Results A total of 64 women were identified as having TNBC (17.5% of all female breast cancer patients, 12.6% were basal-like, 4.9% were unclassified subtype, with a median age of 45 years. The median histological tumor diameter was 4.3 cm. TNBC were most often associated with a high grade, 49.2% grade III (53% for unclassified subtype, 47.6% for basal-like. Vascular invasion was found in 26.6% of cases (22% for unclassified subtype and 28.3% for basal-like. For the lymph node involvement: 51% had positive lymph nodes, and 22.4% had distant metastases. Neoadjuvant chemotherapy was administered to 18% patients with 26% of complete pathologic response; therefore adjuvant chemotherapy was given to 82%. 98% received anthracycline based regimen and only 30% received taxanes. The Kaplan-Meier curves based showed the lowest survival probability at 3-years (49% of OS, and 39% of DFS. Conclusion TNBC is associated with young age, high grade tumors, advanced stage at diagnosis, difference chemo response compared to other subtypes, and shortest survival. Critical to optimal future management is accurate identification of truly triple

  1. Outcomes of stage IIB osteosarcoma treated by limb salvage surgery using extracorporeally irradiated (ECI autograft

    Directory of Open Access Journals (Sweden)

    Achmad F. Kamal

    2011-05-01

    Full Text Available Background: Extracorporeally irradiated (ECI technique is an alternative of limb salvage procedure in treating osteosarcoma regarding limitation of endoprosthesis and allograft. This study evaluated the outcomes of limb salvage surgery using extracorporeally irradiated (ECI autograft and its correlation with patient’s characteristics.Methods: Retrospective cohort design was performed to study 20 patients with stage IIB osteosarcoma treated by ECI autograft from 1995 to 2008. Survival, local recurrence, metastases, complications, union time and functional score based on Musculoskeletal Tumor Society scoring system-(MSTS were evaluated. Kaplan-Meier method was used to describe survival, local recurrence free survival, and metastases free survival. The correlation among patient’s characteristics that were age, gender, duration, site of tumor size, type of osteosarcoma, SAP (serum alkaline phosphatase level, type of biopsy, and type of Huvos were analyzed by Log rank test. Chi-square test was used to analyze the correlation between MSTS score and patient’s characteristics, local recurrence, metastases, complications.Results: Five-year survival was 54.97 ± 9.8 %, five-year local recurrence free survival was 66.5 ± 7.6%, and five year metastasis-free survival was 57.13 ± 10.04%. Six patients died, five were due to lung metastases and one due to complication of chemotherapy. Three underwent amputation after local recurrence. Kaplan-Meier curve showed that a good type of Huvos (III, IV always gave better survival, local recurrence free survival, and metastases free survival than poor type of Huvos (I,II. Normal SAP level gave better local recurrence free survival compare to increased level of SAP. Mean of union rate was 8.13 months. MSTS mean score was good (70.63% in patients with no evidence of disease. MSTS score was poor in patients with local recurrence (p = 0.025, metastases (p = 0.01, complications (p = 0.03, and the

  2. Durability of lopinavir/r monotherapy in people with viral load ≤50 copies/Ml

    Directory of Open Access Journals (Sweden)

    A d'Arminio Monforte

    2012-11-01

    Full Text Available There is debate about whether lopinavir/r mono-therapy (LPV/r-MT is a valid treatment option for HIV-infected patients who have shown perfect adherence to therapy. The objective was to evaluate the durability of LPV/r-MT in terms of time to virological rebound (VR, time to discontinuation/intensification or a composite endpoint considering both (=treatment failure. We also identified factors associated with faster progression to treatment failure and estimated the median CD4 count over time while people were still on LPV/r-MT. Patients enrolled in 10 clinical sites in Italy who ever started LPV/r-MT with a viral load ≤50 copies/mL (baseline are included. Patients’ follow-up accrued from baseline to the date of the event of interest (VR, defined using the thresholds of 50 and 200 copies/mL, or discontinuation/intensification or at the date of last available visit/VL measurement. Standard survival analysis employing Kaplan-Meier curves was used. We studied 139 patients starting LPV/r-MT on average in 2010 (IQR: 2009–2011 with a VL≤50 copies/mL already for a median of 1 month (range: 1–17. Median age 45 years (IQR: 39–50, 35% females, 32% IDU. Median time from first initiation of ART was 33 months (16–58 with no history of virological failure. Median (IQR marker values at baseline were 611 (432–741 CD4 count cells/mm3, 937 (655–1254 CD8 count and 28 (19–47 IU/L of ALT. Median CD4 count were 519 cells/mm3 at 3 months, 660 at 6 months, 603 at 9 months and 467 at 12 months. The table shows the Kaplan-Meier estimates by 1 year and 2 years for a number of endpoints examined. There was a wide range of estimates depending on the endpoint used. Of those stopping/intensifying, 6 people (4% added Truvada (n=4, Kivexa (n=1 and darunavir (n=1, the remaining 8 restarted cART.In our ‘real-life’ setting, by 2 years of starting LPV/r-MT, 70% of patients remained persistently suppressed ≤50 copies/mL. This percentage was >80% when

  3. Algebraic points on meromorphic curves

    CERN Document Server

    Herblot, Mathilde

    2012-01-01

    The classic Schneider-Lang theorem in transcendence theory asserts that there are only finitely many points at which algebraically independent complex meromorphic functions of finite order of growth can simultaneously take values in a number field, when satisfying a polynomial differential equation with coefficients in this given number field. In this article, we are interested in generalizing this theorem in two directions. First, instead of considering meromorphic functions on C we consider holomorphic maps on an affine curve over the field C or C_p. This extends a statement of D. Bertrand, which applies to meromorphic functions on P^1(C) or P^1(C_p) minus a finite subset of points. Secondly, we deal with algebraic values taken by the functions, instead of rational values as in the classic setting, inspired by a work of D. Bertrand. We prove a geometric statement extending those two results, using the slopes method, written in the language of Arakelov geometry. In the complex case, we recover a special case...

  4. Quantum fields in curved spacetime

    Energy Technology Data Exchange (ETDEWEB)

    Hollands, Stefan, E-mail: stefan.hollands@uni-leipzig.de [Universität Leipzig, Institut für Theoretische Physik, Brüderstrasse 16, D-04103 Leipzig (Germany); Wald, Robert M., E-mail: rmwa@uchicago.edu [Enrico Fermi Institute and Department of Physics, University of Chicago, Chicago, IL 60637 (United States)

    2015-04-16

    We review the theory of quantum fields propagating in an arbitrary, classical, globally hyperbolic spacetime. Our review emphasizes the conceptual issues arising in the formulation of the theory and presents known results in a mathematically precise way. Particular attention is paid to the distributional nature of quantum fields, to their local and covariant character, and to microlocal spectrum conditions satisfied by physically reasonable states. We review the Unruh and Hawking effects for free fields, as well as the behavior of free fields in deSitter spacetime and FLRW spacetimes with an exponential phase of expansion. We review how nonlinear observables of a free field, such as the stress–energy tensor, are defined, as well as time-ordered-products. The “renormalization ambiguities” involved in the definition of time-ordered products are fully characterized. Interacting fields are then perturbatively constructed. Our main focus is on the theory of a scalar field, but a brief discussion of gauge fields is included. We conclude with a brief discussion of a possible approach towards a nonperturbative formulation of quantum field theory in curved spacetime and some remarks on the formulation of quantum gravity.

  5. Simulations of Closed Timelike Curves

    Science.gov (United States)

    Brun, Todd A.; Wilde, Mark M.

    2017-03-01

    Proposed models of closed timelike curves (CTCs) have been shown to enable powerful information-processing protocols. We examine the simulation of models of CTCs both by other models of CTCs and by physical systems without access to CTCs. We prove that the recently proposed transition probability CTCs (T-CTCs) are physically equivalent to postselection CTCs (P-CTCs), in the sense that one model can simulate the other with reasonable overhead. As a consequence, their information-processing capabilities are equivalent. We also describe a method for quantum computers to simulate Deutschian CTCs (but with a reasonable overhead only in some cases). In cases for which the overhead is reasonable, it might be possible to perform the simulation in a table-top experiment. This approach has the benefit of resolving some ambiguities associated with the equivalent circuit model of Ralph et al. Furthermore, we provide an explicit form for the state of the CTC system such that it is a maximum-entropy state, as prescribed by Deutsch.

  6. p-Curve and p-Hacking in Observational Research.

    Directory of Open Access Journals (Sweden)

    Stephan B Bruns

    Full Text Available The p-curve, the distribution of statistically significant p-values of published studies, has been used to make inferences on the proportion of true effects and on the presence of p-hacking in the published literature. We analyze the p-curve for observational research in the presence of p-hacking. We show by means of simulations that even with minimal omitted-variable bias (e.g., unaccounted confounding p-curves based on true effects and p-curves based on null-effects with p-hacking cannot be reliably distinguished. We also demonstrate this problem using as practical example the evaluation of the effect of malaria prevalence on economic growth between 1960 and 1996. These findings call recent studies into question that use the p-curve to infer that most published research findings are based on true effects in the medical literature and in a wide range of disciplines. p-values in observational research may need to be empirically calibrated to be interpretable with respect to the commonly used significance threshold of 0.05. Violations of randomization in experimental studies may also result in situations where the use of p-curves is similarly unreliable.

  7. p-Curve and p-Hacking in Observational Research.

    Science.gov (United States)

    Bruns, Stephan B; Ioannidis, John P A

    2016-01-01

    The p-curve, the distribution of statistically significant p-values of published studies, has been used to make inferences on the proportion of true effects and on the presence of p-hacking in the published literature. We analyze the p-curve for observational research in the presence of p-hacking. We show by means of simulations that even with minimal omitted-variable bias (e.g., unaccounted confounding) p-curves based on true effects and p-curves based on null-effects with p-hacking cannot be reliably distinguished. We also demonstrate this problem using as practical example the evaluation of the effect of malaria prevalence on economic growth between 1960 and 1996. These findings call recent studies into question that use the p-curve to infer that most published research findings are based on true effects in the medical literature and in a wide range of disciplines. p-values in observational research may need to be empirically calibrated to be interpretable with respect to the commonly used significance threshold of 0.05. Violations of randomization in experimental studies may also result in situations where the use of p-curves is similarly unreliable.

  8. Error Model of Curves in GIS and Digitization Experiment

    Institute of Scientific and Technical Information of China (English)

    GUO Tongde; WANG Jiayao; WANG Guangxia

    2006-01-01

    A stochastic error process of curves is proposed as the error model to describe the errors of curves in GIS. In terms of the stochastic process, four characteristics concerning the local error of curves, namely, mean error function, standard error function, absolute error function, and the correlation function of errors , are put forward. The total error of a curve is expressed by a mean square integral of the stochastic error process. The probabilistic meanings and geometric meanings of the characteristics mentioned above are also discussed. A scan digitization experiment is designed to check the efficiency of the model. In the experiment, a piece of contour line is digitized for more than 100 times and lots of sample functions are derived from the experiment. Finally, all the error characteristics are estimated on the basis of sample functions. The experiment results show that the systematic error in digitized map data is not negligible, and the errors of points on curves are chiefly dependent on the curvature and the concavity of the curves.

  9. Growth curves in Down syndrome with congenital heart disease

    Directory of Open Access Journals (Sweden)

    Caroline D’Azevedo Sica

    Full Text Available SUMMARY Introduction: To assess dietary habits, nutritional status and food frequency in children and adolescents with Down syndrome (DS and congenital heart disease (CHD. Additionally, we attempted to compare body mass index (BMI classifications according to the World Health Organization (WHO curves and curves developed for individuals with DS. Method: Cross-sectional study including individuals with DS and CHD treated at a referral center for cardiology, aged 2 to 18 years. Weight, height, BMI, total energy and food frequency were measured. Nutritional status was assessed using BMI for age and gender, using curves for evaluation of patients with DS and those set by the WHO. Results: 68 subjects with DS and CHD were evaluated. Atrioventricular septal defect (AVSD was the most common heart disease (52.9%. There were differences in BMI classification between the curves proposed for patients with DS and those proposed by the WHO. There was an association between consumption of vitamin E and polyunsaturated fatty acids. Conclusion: Results showed that individuals with DS are mostly considered normal weight for age, when evaluated using specific curves for DS. Reviews on specific curves for DS would be the recommended practice for health professionals so as to avoid precipitated diagnosis of overweight and/or obesity in this population.

  10. Bending the Curve: Sensitivity to Bending of Curved Paths and Application in Room-Scale VR.

    Science.gov (United States)

    Langbehn, Eike; Lubos, Paul; Bruder, Gerd; Steinicke, Frank

    2017-04-01

    Redirected walking (RDW) promises to allow near-natural walking in an infinitely large virtual environment (VE) by subtle manipulations of the virtual camera. Previous experiments analyzed the human sensitivity to RDW manipulations by focusing on the worst-case scenario, in which users walk perfectly straight ahead in the VE, whereas they are redirected on a circular path in the real world. The results showed that a physical radius of at least 22 meters is required for undetectable RDW. However, users do not always walk exactly straight in a VE. So far, it has not been investigated how much a physical path can be bent in situations in which users walk a virtual curved path instead of a straight one. Such curved walking paths can be often observed, for example, when users walk on virtual trails, through bent corridors, or when circling around obstacles. In such situations the question is not, whether or not the physical path can be bent, but how much the bending of the physical path may vary from the bending of the virtual path. In this article, we analyze this question and present redirection by means of bending gains that describe the discrepancy between the bending of curved paths in the real and virtual environment. Furthermore, we report the psychophysical experiments in which we analyzed the human sensitivity to these gains. The results reveal encouragingly wider detection thresholds than for straightforward walking. Based on our findings, we discuss the potential of curved walking and present a first approach to leverage bent paths in a way that can provide undetectable RDW manipulations even in room-scale VR.

  11. Bolometric Light Curves of Peculiar Type II-P Supernovae

    Science.gov (United States)

    Lusk, Jeremy A.; Baron, E.

    2017-04-01

    We examine the bolometric light curves of five Type II-P supernovae (SNe 1998A, 2000cb, 2006V, 2006au, and 2009E), which are thought to originate from blue supergiant progenitors like that of SN 1987A, using a new python package named SuperBoL. With this code, we calculate SNe light curves using three different common techniques common from the literature: the quasi-bolometric method, which integrates the observed photometry, the direct integration method, which additionally corrects for unobserved flux in the UV and IR, and the bolometric correction method, which uses correlations between observed colors and V-band bolometric corrections. We present here the light curves calculated by SuperBoL, along with previously published light curves, as well as peak luminosities and 56Ni yields. We find that the direct integration and bolometric correction light curves largely agree with previously published light curves, but with what we believe to be more robust error calculations, with 0.2≲ δ {L}{bol}/{L}{bol}≲ 0.5. Peak luminosities and 56Ni masses are similarly comparable to previous work. SN 2000cb remains an unusual member of this sub-group, owing to the faster rise and flatter plateau than the other supernovae in the sample. Initial comparisons with the NLTE atmosphere code PHOENIX show that the direct integration technique reproduces the luminosity of a model supernova spectrum to ∼5% when given synthetic photometry of the spectrum as input. Our code is publicly available. The ability to produce bolometric light curves from observed sets of broadband light curves should be helpful in the interpretation of other types of supernovae, particularly those that are not well characterized, such as extremely luminous supernovae and faint fast objects.

  12. MICROMOLDING ON CURVED SURFACES WITH THERMOPLASTICS

    Institute of Scientific and Technical Information of China (English)

    Bang-kun Jin; Xiao-song Wu; Ping-sheng He; Li-jia Pan

    2003-01-01

    Microstructures were produced on curved surfaces and micro-protrusions by using direct micromolding with four thermoplastic polymers. This method is simpler and more convenient than micromolding with liquid prepolymer or using the μTM method. By repeated molding, crossed structures were produced with a stamp prepared only with lines. The processing variables including the softening temperature of the polymers and heating time were discussed. The result shows that the optimal molding temperature is preferably slightly higher than the melting temperature of the thermoplastic polymers, at which polymers are in the critical states of being melted. This method can be applied to many polymers except those with high softening temperatures or high rate of shrinkage upon temperature change.

  13. Topology and Closed Timelike Curves I: Dynamics

    CERN Document Server

    Monroe, H

    2006-01-01

    No closed timelike curve (CTC) on a Lorentzian manifold can be continuously deformed as a CTC to a point. Otherwise, any of the point's neighborhoods would contain a CTC, a contradiction as Lorentzian manifolds are locally causally well-behaved. Every CTC must pass through some topological feature, to be called a timelike wormhole, which prevents the it from being deformed to a point. Tipler showed that a closed timelike geodesic exists in a compact Lorentzian manifold if the covering space contains a compact Cauchy surface. A test particle free falling along this geodesic transits the timelike wormhole; in the test particle's frame of reference, the wormhole propagates toward the test particle, exhibiting photon-like behavior. In addition, a space-time that violates chronology at every point can experience topology change consistent with theorems of Geroch and Tipler.

  14. Quantum fields on closed timelike curves

    Energy Technology Data Exchange (ETDEWEB)

    Pienaar, J. L.; Myers, C. R.; Ralph, T. C. [School of Mathematics and Physics, The University of Queensland, Brisbane 4072, Queensland (Australia)

    2011-12-15

    Recently, there has been much interest in the evolution of quantum particles on closed timelike curves (CTCs). However, such models typically assume pointlike particles with only two degrees of freedom; a very questionable assumption given the relativistic setting of the problem. We show that it is possible to generalize the Deutsch model of CTCs to fields using the equivalent circuit formalism. We give examples for coherent, squeezed, and single-photon states interacting with the CTC via a beamsplitter. The model is then generalized further to account for the smooth transition to normal quantum mechanics as the CTC becomes much smaller than the size of the modes interacting on it. In this limit, we find that the system behaves like a standard quantum-mechanical feedback loop.

  15. Forced convective heat transfer in curved diffusers

    Science.gov (United States)

    Rojas, J.; Whitelaw, J. H.; Yianneskis, M.

    1987-01-01

    Measurements of the velocity characteristics of the flows in two curved diffusers of rectangular cross section with C and S-shaped centerlines are presented and related to measurements of wall heat transfer coefficients along the heated flat walls of the ducts. The velocity results were obtained by laser-Doppler anemometry in a water tunnel and the heat transfer results by liquid crystal thermography in a wind tunnel. The thermographic technique allowed the rapid and inexpensive measurement of wall heat transfer coefficients along flat walls of arbitrary boundary shapes with an accuracy of about 5 percent. The results show that an increase in secondary flow velocities near the heated wall causes an increase in the local wall heat transfer coefficient, and quantify the variation for maximum secondary-flow velocities in a range from 1.5 to 17 percent of the bulk flow velocity.

  16. Topological Sound and Flocking on Curved Surfaces

    Directory of Open Access Journals (Sweden)

    Suraj Shankar

    2017-09-01

    Full Text Available Active systems on curved geometries are ubiquitous in the living world. In the presence of curvature, orientationally ordered polar flocks are forced to be inhomogeneous, often requiring the presence of topological defects even in the steady state because of the constraints imposed by the topology of the underlying surface. In the presence of spontaneous flow, the system additionally supports long-wavelength propagating sound modes that get gapped by the curvature of the underlying substrate. We analytically compute the steady-state profile of an active polar flock on a two-sphere and a catenoid, and show that curvature and active flow together result in symmetry-protected topological modes that get localized to special geodesics on the surface (the equator or the neck, respectively. These modes are the analogue of edge states in electronic quantum Hall systems and provide unidirectional channels for information transport in the flock, robust against disorder and backscattering.

  17. Are High Proanthocyanidins Key to Cranberry Efficacy in the Prevention of Recurrent Urinary Tract Infection?

    Science.gov (United States)

    Vostalova, Jitka; Vidlar, Ales; Simanek, Vilim; Galandakova, Adela; Kosina, Pavel; Vacek, Jan; Vrbkova, Jana; Zimmermann, Benno F; Ulrichova, Jitka; Student, Vladimir

    2015-10-01

    Most research on American cranberry in the prevention of urinary tract infection (UTI) has used juices. The spectrum of components in juice is limited. This study tested whether whole cranberry fruit powder (proanthocyanidin content 0.56%) could prevent recurrent UTI in 182 women with two or more UTI episodes in the last year. Participants were randomized to a cranberry (n = 89) or a placebo group (n = 93) and received daily 500 mg of cranberry for 6 months. The number of UTI diagnoses was counted. The intent-to-treat analyses showed that in the cranberry group, the UTIs were significantly fewer [10.8% vs. 25.8%, p = 0.04, with an age-standardized 12-month UTI history (p = 0.01)]. The Kaplan-Meier survival curves showed that the cranberry group experienced a longer time to first UTI than the placebo group (p = 0.04). Biochemical parameters were normal, and there was no significant difference in urinary phenolics between the groups at baseline or on day180. The results show that cranberry fruit powder (peel, seeds, pulp) may reduce the risk of symptomatic UTI in women with a history of recurrent UTIs.

  18. Outcome and CT differentiation of gallbladder neuroendocrine tumours from adenocarcinomas

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Tae-Hyung [Seoul National University Hospital, Department of Radiology, Seoul (Korea, Republic of); Kim, Se Hyung [Seoul National University Hospital, Department of Radiology, Seoul (Korea, Republic of); Seoul National University Hospital and Seoul National University College of Medicine, Department of Radiology, Seoul (Korea, Republic of); Seoul National University College of Medicine, Department of Radiology, Seoul (Korea, Republic of); Lee, Kyoung Boon [Seoul National University Hospital, Department of Pathology, Seoul (Korea, Republic of); Han, Joon Koo [Seoul National University Hospital, Department of Radiology, Seoul (Korea, Republic of); Seoul National University College of Medicine, Department of Radiology, Seoul (Korea, Republic of); Seoul National University Medical Research Center, Institute of Radiation Medicine, Seoul (Korea, Republic of)

    2017-02-15

    To retrospectively investigate clinical outcome and differential CT features of gallbladder (GB) neuroendocrine tumours (NETs) from adenocarcinomas (ADCs). Nineteen patients with poorly-differentiated (PD) NETs and 19 patients with PD ADCs were enrolled. Clinical outcome was compared by the Kaplan-Meier method. We assessed qualitative and quantitative CT features to identify significant differential CT features of PD NETs from ADCs using univariate and multivariate analyses. Receiver operating characteristic (ROC) analysis was used for quantitative CT features. PD NETs showed poorer prognosis with significantly shorter median survival days than ADCs (363 vs. 590 days, P = 0.03). On univariate analysis, NETs more frequently manifested as GB-replacing type and showed well-defined margins accompanied with intact overlying mucosa. On multivariate analysis, well-defined margin was the sole significant CT differentiator (odds ratio = 27.817, P = 0.045). Maximum size of hepatic and lymph node (LN) metastases was significantly larger in NETs (11.0 cm and 4.62 cm) than ADCs (2.40 cm and 2.41 cm). Areas under ROC curves for tumour-to-mucosa ratio, maximum size of hepatic and LN metastasis were 0.772, 0.932 and 0.919, respectively (P < 0.05). GB PD NETs show poorer prognosis than ADCs. Well-defined margin, larger hepatic and LN metastases are useful CT differentiators of GB NETs from ADCs. (orig.)

  19. Preclinical demonstration of synergistic Active Nutrients/Drug (AND combination as a potential treatment for malignant pleural mesothelioma.

    Directory of Open Access Journals (Sweden)

    Viviana Volta

    Full Text Available Malignant pleural mesothelioma (MPM is a poor prognosis disease lacking adequate therapy. We have previously shown that ascorbic acid administration is toxic to MPM cells. Here we evaluated a new combined therapy consisting of ascorbate/epigallocatechin-3-gallate/gemcitabine mixture (called AND, for Active Nutrients/Drug. In vitro effects of AND therapy on various MPM cell lines revealed a synergistic cytotoxic mechanism. In vivo experiments on a xenograft mouse model for MPM, obtained by REN cells injection in immunocompromised mice, showed that AND strongly reduced the size of primary tumor as well as the number and size of metastases, and prevented abdominal hemorrhage. Kaplan Meier curves and the log-rank test indicated a marked increase in the survival of AND-treated animals. Histochemical analysis of dissected tumors showed that AND induced a shift from cell proliferation to apoptosis in cancer cells. Lysates of tumors from AND-treated mice, analyzed with an antibody array, revealed decreased TIMP-1 and -2 expressions and no effects on angiogenesis regulating factors. Multiplex analysis for signaling protein phosphorylation exhibited inactivation of cell proliferation pathways. The complex of data showed that the AND treatment is synergistic in vitro on MPM cells, and blocks in vivo tumor progression and metastasization in REN-based xenografts. Hence, the AND combination is proposed as a new treatment for MPM.

  20. Novel nitric oxide producing probiotic wound healing patch: preparation and in vivo analysis in a New Zealand white rabbit model of ischaemic and infected wounds.

    Science.gov (United States)

    Jones, Mitchell; Ganopolsky, Jorge G; Labbé, Alain; Gilardino, Mirko; Wahl, Christopher; Martoni, Christopher; Prakash, Satya

    2012-06-01

    The treatment of chronic wounds poses a significant challenge for clinicians and patients alike. Here we report design and preclinical efficacy of a novel nitric oxide gas (gNO)-producing probiotic patch for wound healing. Specifically, a wound healing patch using lactic acid bacteria in an adhesive gas permeable membrane has been designed and investigated for treating ischaemic and infected full-thickness dermal wounds in a New Zealand white rabbit model for ischaemic wound healing. Kaplan-Meier survival curves showed increased wound closure with gNO-producing patch-treated wounds over 21 days of therapy (log-rank P = 0·0225 and Wilcoxon P = 0·0113). Cox proportional hazard regression showed that gNO-producing patch-treated wounds were 2·52 times more likely to close compared with control patches (hazard P = 0·0375, score P = 0·032 and likelihood ratio P = 0·0355), and histological analysis showed improved wound healing in gNO-producing patch-treated animals. This study may provide an effective, safe and less costly alternative for treating chronic wounds. © 2012 The Authors. © 2012 Blackwell Publishing Ltd and Medicalhelplines.com Inc.

  1. Impact of immunosuppression treatment on the improvement in graft survival after deceased donor renal transplantation: a long-term cohort study.

    Science.gov (United States)

    González-Molina, Miguel; Burgos, Dolores; Cabello, Mercedes; Ruiz-Esteban, Pedro; Rodríguez, Manuel A; Gutiérrez, Cristina; López, Verónica; Baena, Víctor; Hernández, Domingo

    2014-01-01

    We analyzed graft half-life and attrition rates in 1045 adult deceased donor kidney transplants from 1986-2001, with follow-up to 2011, grouped in two periods (1986-95 vs. 1996-01) according to immunosuppression. The Kaplan-Meier curve showed a significant increase in graft survival during 1996-2001. The uncensored real graft half-life was 10.25 years in 1986-95 and the actuarial was 14.58 years in 1996-2001 (P<0.001). The attrition rates showed a significantly greater graft loss in 1986-95, even excluding the first year from the analysis. The decline in renal function was significantly less pronounced in 1996-2001, indicating better preservation of renal function, despite the increase in donor age and stroke as the cause of donor death. The parsimonious Cox multivariate model showed donor age, acute rejection, panel reactive antibody, cold ischemia time and delayed graft function were significantly associated with a higher risk of graft loss. In contrast, the risk of graft loss fell by 21% in 1996-2001 compared with 1986-95. A similar reduction (25%) was observed when MMF treatment was entered into the multivariate model instead of study period. Long-term graft survival improved significantly in 1996-2001 compared to 1986-1995 despite older donor age. Modern immunosuppression could have contributed to the improved kidney transplant outcome.

  2. Visceral adiposity index and prognosis among patients with ischemic heart failure

    Directory of Open Access Journals (Sweden)

    Patrícia Vogel

    Full Text Available ABSTRACT: CONTEXT AND OBJECTIVES: The obesity paradox has already been established in relation to heart failure, but it is not known which obesity indicator best reflects this phenomenon. The aim of this study was to evaluate the association between obesity indexes and mortality among patients with heart failure. DESIGN AND SETTING: Cohort study conducted in the Department of Cardiology of Hospital Nossa Senhora da Conceição (Brazil. METHODS: Clinical, demographic, socioeconomic, biochemical and anthropometric data on 116 patients aged 30 to 85 years with a diagnosis of heart failure were evaluated. Arm fat area, body mass index, body surface area, body adiposity index, lipid accumulation product (LAP and visceral adiposity index (VAI were calculated. Cox regression was used to perform survival analyses. RESULTS: At baseline, the individuals with ischemic heart failure who remained alive showed higher VAI (3.60 ± 3.71 versus 1.48 ± 1.58; P = 0.04 and a trend towards higher LAP, in comparison with the individuals who died. After an average follow-up of 14.3 months, ischemic heart failure patients who had VAI > 1.21 showed 78% lower risk of death (HR 0.12; 95% CI: 0.02-0.67; P = 0.02 and the Kaplan-Meier survival curves showed better prognosis for these individuals (P = 0.005; log-rank test. CONCLUSION: Our results suggest that VAI is a good predictor of better prognosis among ischemic heart failure patients.

  3. Certified Approximation of Parametric Space Curves with Cubic B-spline Curves

    CERN Document Server

    Shen, Liyong; Gao, Xiao-Shan

    2012-01-01

    Approximating complex curves with simple parametric curves is widely used in CAGD, CG, and CNC. This paper presents an algorithm to compute a certified approximation to a given parametric space curve with cubic B-spline curves. By certified, we mean that the approximation can approximate the given curve to any given precision and preserve the geometric features of the given curve such as the topology, singular points, etc. The approximated curve is divided into segments called quasi-cubic B\\'{e}zier curve segments which have properties similar to a cubic rational B\\'{e}zier curve. And the approximate curve is naturally constructed as the associated cubic rational B\\'{e}zier curve of the control tetrahedron of a quasi-cubic curve. A novel optimization method is proposed to select proper weights in the cubic rational B\\'{e}zier curve to approximate the given curve. The error of the approximation is controlled by the size of its tetrahedron, which converges to zero by subdividing the curve segments. As an applic...

  4. Asymptotic properties of the sequential empirical ROC, PPV and NPV curves under case-control sampling

    CERN Document Server

    Koopmeiners, Joseph S; 10.1214/11-AOS937

    2012-01-01

    The receiver operating characteristic (ROC) curve, the positive predictive value (PPV) curve and the negative predictive value (NPV) curve are three measures of performance for a continuous diagnostic biomarker. The ROC, PPV and NPV curves are often estimated empirically to avoid assumptions about the distributional form of the biomarkers. Recently, there has been a push to incorporate group sequential methods into the design of diagnostic biomarker studies. A thorough understanding of the asymptotic properties of the sequential empirical ROC, PPV and NPV curves will provide more flexibility when designing group sequential diagnostic biomarker studies. In this paper, we derive asymptotic theory for the sequential empirical ROC, PPV and NPV curves under case-control sampling using sequential empirical process theory. We show that the sequential empirical ROC, PPV and NPV curves converge to the sum of independent Kiefer processes and show how these results can be used to derive asymptotic results for summaries ...

  5. Research on physical shape preserving curve reconstruction

    Institute of Scientific and Technical Information of China (English)

    TANG Kelun; ZHANG Xiangwei; CHENG Siyuan; XIONG Hanwei; ZHANG Hong

    2007-01-01

    Fusion of various data is an effective way to improve the precision and efficiency of acquiring information in reverse engineering.A method of physical shape preserving curve reconstruction is proposed to better realize the data fusion of coordinate measuring machine (CMM) and visual information.From the principle of materials mechanics,the strain energy of the curve corresponding to the distortion is advanced as the internal energy,and the elastic potential energy of the curve is established,using a few precise measured data points as the equilibrium position,to be the external energy.On the basis of the principle of variation calculus,the basic spline finite element method (B-spline FEM) is used to determine the equilibrium position of curve deformation.Numerical simulation indicates that there is an extremely good agreement between the new fitted curve and the actual curve.

  6. Forces in the complex octonion curved space

    CERN Document Server

    Weng, Zi-Hua

    2016-01-01

    The paper aims to extend major equations in the electromagnetic and gravitational theories from the flat space into the complex octonion curved space. Maxwell applied simultaneously the quaternion analysis and vector terminology to describe the electromagnetic theory. It inspires subsequent scholars to study the electromagnetic and gravitational theories with the complex quaternions/octonions. Furthermore Einstein was the first to depict the gravitational theory by means of tensor analysis and curved four-space-time. Nowadays some scholars investigate the electromagnetic and gravitational properties making use of the complex quaternion/octonion curved space. From the orthogonality of two complex quaternions, it is possible to define the covariant derivative of the complex quaternion curved space, describing the gravitational properties in the complex quaternion curved space. Further it is possible to define the covariant derivative of the complex octonion curved space by means of the orthogonality of two comp...

  7. The Cayley-Bacharach Theorem for Continuous Piecewise Algebraic Curves over Cross-cut Triangulations

    Institute of Scientific and Technical Information of China (English)

    Renhong WANG; Shaofan WANG

    2011-01-01

    A piecewise algebraic curve is a curve determined by the zero set of a bivariate spline function.In this paper,we propose the Cayley-Bacharach theorem for continuous piecewise algebraic curves over cross-cut triangulations.We show that,if two continuous piecewise algebraic curves of degrees m and n respectively meet at mnT distinct points over a cross-cut triangulation,where T denotes the number of cells of the triangulation,then any continuous piecewise algebraic curve of degree m + n - 2 containing all but one point of them also contains the last point.

  8. Statistics for traces of cyclic trigonal curves over finite fields

    CERN Document Server

    Bucur, Alina; Feigon, Brooke; Lalín, Matilde

    2009-01-01

    In this paper we study the variation of the trace of the Frobenius endomorphism associated to a cyclic trigonal curve of genus g over a field of q elements as the curve varies in an irreducible component of the moduli space. We show that for q fixed and g increasing, the limiting distribution of the trace of the Frobenius endomorphism is equal to the sum of q+1 independent random variables taking the value 0 with probability 2/(q+2) and taking the values 1, e^{(2pi i)/3}, e^{(4pi i)/3} with probability q/(3(q+2)). This extends the work of Kurlberg and Rudnick who considered the same limit for the case of hyperelliptic curves. We also show that when both the genus and q go to infinity, the normalized trace has a complex Gaussian distribution with mean 0 and variance 1.

  9. Non-linear Behavior of Curved Sandwich Panels

    DEFF Research Database (Denmark)

    Berggreen, Carl Christian; Jolma, P.; Karjalainen, J. P.;

    2003-01-01

    In this paper the non-linear behavior of curved sandwich panels is investigated both numerically and experimentally. Focus is on various aspects of finite element modeling and calculation procedures. A simply supported, singly curved, CFRP/PVC sandwich panel is analyzed under uniform pressure load...... and results are compared to test data. A novel test arrangement utilizing a water filled cushion to create the uniform pressure load on curved panel specimen is used to obtain the experimental data. The panel is modeled with three different commercial finite element codes. Two implicit and one explicit code...... are used with various element types, modeling approaches and material models. The results show that the theoretical and experimental methods generally show fair agreement in panel non-linear behavior before collapse. It is also shown that special attention to detail has to be taken, because the predicted...

  10. Conditionally bounding analytic ranks of elliptic curves

    CERN Document Server

    Bober, Jonathan W

    2011-01-01

    We describe a method for bounding the rank of an elliptic curve under the assumptions of the Birch and Swinnerton-Dyer conjecture and the generalized Riemann hypothesis. As an example, we compute, under these conjectures, exact upper bounds for curves which are known to have rank at least as large as 20, 21, 22, 23, and 24. For the known curve of rank at least 28, we get a bound of 30.

  11. Riemann Boundary Value Problems for Koch Curve

    Directory of Open Access Journals (Sweden)

    Zhengshun Ruanand

    2012-11-01

    Full Text Available In this study, when L is substituted for Koch curve, Riemann boundary value problems was defined, but generally speaking, Cauchy-type integral is meaningless on Koch curve. When some analytic conditions are attached to functions G (z and g (z, through the limit function of a sequence of Cauchytype integrals, the homogeneous and non-homogeneous Riemann boundary problems on Koch curve are introduced, some similar results was attained like the classical boundary value problems for analytic functions.

  12. Skill Acquisition Curves and Military Training

    Science.gov (United States)

    1986-01-01

    group acquisition curves had one of two general shapes, either logarithmic (power function) or semi- logarithmic (exponential), including variants...is, so far as we aware, no inherent advantage to the use of equations in linear or logarithmic form other than that the display of fitted curves in...implications for the expected form of the acquisition curve . As Mazur and Hastie (1978) note, accumulation models yield the hyperbola (a power law

  13. A Local Torelli's Theorem for SUSY curves

    CERN Document Server

    Codogni, Giulio

    2014-01-01

    SUSY curves, or super Riemann surfaces, are the generalization of Riemann surfaces in the context of super geometry. The main goal of this paper is to construct some explicit families of SUSY curves with odd moduli and compute their periods. By comparing our result with its classical analogue, we make an educated guess about the tangent space to the period domain and the differential of the Jacobian morphism for SUSY curves.

  14. Planning a Successful Tech Show

    Science.gov (United States)

    Nikirk, Martin

    2011-01-01

    Tech shows are a great way to introduce prospective students, parents, and local business and industry to a technology and engineering or career and technical education program. In addition to showcasing instructional programs, a tech show allows students to demonstrate their professionalism and skills, practice public presentations, and interact…

  15. Overexpression of ADAMTS5 can regulate the migration and invasion of non-small cell lung cancer.

    Science.gov (United States)

    Gu, Jun; Chen, Jie; Feng, Jian; Liu, Yifei; Xue, Qun; Mao, Guoxin; Gai, Ling; Lu, Xiaoning; Zhang, Rui; Cheng, Jialin; Hu, Yanxia; Shao, Mengting; Shen, Hong; Huang, Jianan

    2016-07-01

    Non-small cell lung cancer (NSCLC) is the major cause of cancer-related lethality among human cancer patients globally, and the poor prognosis of this cancer is mainly explained by metastasis, so it is essential to find out the molecule mechanisms and a novel therapeutic for NSCLC. A disintegrin and metalloprotease with thrombospondin motif 5 (ADAMTS5) belongs to the protease family. It has been reported to participate in tumor migration and invasion. In this study, we showed that the expression of ADAMTS5 was higher in lung cancer tissues by Western blot. The immunohistochemistry analysis was performed in 140 NSCLC cases, and the result indicated that ADAMTS5 was significantly associated with clinical pathologic variables. The Kaplan-Meier curve showed that the high expression of ADAMTS5 was related to poor prognosis of lung cancer patients. Wound healing assays and transwell migration assays revealed that the high expression of ADAMTS5 promoted the migration and invasion of NSCLC. In a word, our findings suggest that ADAMTS5 can regulate the migration and invasion of NSCLC and it may be a useful target of therapy in NSCLC.

  16. Prognostic value of total lesion glycolysis on preoperative {sup 18}F-FDG PET/CT in patients with uterine carcinosarcoma

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jeong-Won [Sungkyunkwan University School of Medicine, Department of Obstetrics and Gynecology, Seoul (Korea, Republic of); Sungkyunkwan University School of Medicine, Samsung Advanced Institute for Health Sciences and Technology, Seoul (Korea, Republic of); Heo, Eun Jin [Sungkyunkwan University School of Medicine, Department of Obstetrics and Gynecology, Seoul (Korea, Republic of); Moon, Seung Hwan [Sungkyunkwan University School of Medicine, Department of Nuclear Medicine, Seoul (Korea, Republic of); Lee, Hyunjong; Cheon, Gi Jeong [Seoul National University College of Medicine, Department of Nuclear Medicine, Seoul (Korea, Republic of); Lee, Maria; Kim, Hee Seung; Chung, Hyun Hoon [Seoul National University College of Medicine, Department of Obstetrics and Gynecology, Cancer Research Institute, Seoul (Korea, Republic of)

    2016-11-15

    To investigate the relationship between functional tumour parameters measured during preoperative {sup 18}F-FDG PET/CT and clinical outcomes in patients with uterine carcinosarcoma. For patients with pathologically proven uterine carcinosarcoma, we determined the maximal and average standardized uptake values, cumulative total lesion glycolysis (TLG) and sum of all metabolic tumour volumes (MTVs). Their predictive value for recurrence and the effects of pretreatment functional tumour activity on patient survival were compared. Clinicopathological data from 28 eligible patients were reviewed. The median duration of progression-free survival was 18.6 months (range 6.1-84.5 months), and 10 (35.7 %) patients experienced recurrences. Univariate analyses showed significant associations between recurrence and tumour size, lymph node metastasis, high TLG and MTV values, and ovarian invasion. Multivariate analysis identified high TLG value as an independent risk factor for recurrence (p = 0.048, hazard ratio 115.261, 95 % confidence interval 1.041-12,765.483). Kaplan-Meier survival curves showed that progression-free survival significantly differed in groups categorized according to TLG (p = 0.007, log-rank test). Preoperative TLG measured with {sup 18}F-FDG PET/CT was statistically significantly associated with uterine carcinosarcoma recurrence. Metabolic parameters can provide useful quantitative criteria for disease prognostication in patients with uterine carcinosarcoma before treatment. (orig.)

  17. Internal migration and health: premarital sexual initiation in Nigeria.

    Science.gov (United States)

    Mberu, Blessing Uchenna; White, Michael J

    2011-04-01

    The high rates of youth migration to urban and economic centers, in the context of persistent poverty and devastating HIV/AIDS burden, have raised intricate social policy challenges in developing countries. Using the 2008 Nigeria Demographic and Health Survey data, descriptive statistics, Kaplan-Meier survival curves and discrete-time hazard regression models, this study examines the patterns of internal migration and sexual initiation among never-married Nigerian youth aged 15-24. We find that migrants generally show stronger association than non-migrants, and urban-rural and rural-rural migrants particularly show the strongest independent association with premarital sexual initiation. Other significant covariates are age, religion, ethnic origin, educational attainment, independent living arrangement, formal employment and exposure to the mass media. The findings highlight the direct importance of youth migration in understanding and addressing the challenges of premarital sexual behavior and the need for behavior change policies and programs to be sensitive to the complex contextual nuances across youth groups in one country. Copyright © 2011 Elsevier Ltd. All rights reserved.

  18. Gene Methylation Biomarkers in Sputum and Plasma as Predictors for Lung Cancer Recurrence.

    Science.gov (United States)

    Belinsky, Steven A; Leng, Shuguang; Wu, Guodong; Thomas, Cynthia L; Picchi, Maria A; Lee, Sandra J; Aisner, Seena; Ramalingam, Suresh; Khuri, Fadlo R; Karp, Daniel D

    2017-09-13

    Detection of methylated genes in exfoliated cells from the lungs of smokers provides an assessment of the extent of field cancerization, is a validated biomarker for predicting lung cancer, and provides some discrimination when interrogated in blood. The potential utility of this 8-gene methylation panel for predicting tumor recurrence has not been assessed. The Eastern Cooperative Oncology Group initiated a prevention trial (ECOG-ACRIN5597) that enrolled resected Stage I non-small cell lung cancer patients who were randomized 2:1 to receive selenized yeast versus placebo for four years. We conducted a correlative biomarker study to assess prevalence for methylation of the 8-gene panel in longitudinally collected sputum and blood after tumor resection to determine if selenium alters their methylation profile and whether this panel predicts local and/or distant recurrence. Patients (n=1561) were enrolled into the prevention trial, 565 participated in the biomarker study with 122 recurrences among that group. Assessing the association between recurrence and risk of gene methylation longitudinally for up to 48 months showed a 1.4-fold increase in odds ratio for methylation in sputum in the placebo group independent of location (local or distant). Kaplan Meier curves evaluating the association between number of methylated genes and time to recurrence showed no increased risk in sputum, while a significant hazard ratio of 1.5 was seen in plasma. Methylation detection in sputum and blood is associated with risk for recurrence. Copyright ©2017, American Association for Cancer Research.

  19. The treatment of oral leukoplakia with the CO2 laser: A retrospective study of 65 patients.

    Science.gov (United States)

    Mogedas-Vegara, Alfonso; Hueto-Madrid, Juan-Antonio; Chimenos-Küstner, Eduardo; Bescós-Atín, Coro

    2015-06-01

    The use of CO2 laser has become a routine procedure for the treatment of oral leukoplakia. In this retrospective study, we evaluated 65 patients with oral leukoplakia treated with CO2 laser vaporization. The main location was the tongue (n = 21/65, 32.3%). The initial biopsy showed mild/moderate dysplasia in almost half the patients (n = 29, 44.6%) and hyperplasia without dysplasia in around a third of the patients (n = 21, 32.3%). The recurrence and malignant transformation rates were 33.8% (n = 22) and 15.4% (n = 10), respectively. The follow-up mean (standard deviation) was 15.0 (10.6) months. The procedure-related complications rate was 7.7% (n = 5). The Kaplan-Meier curves for time to recurrence showed differences only for gingiva lesions compared to tongue lesions (log rank, p = 0.032). Malignant leukoplakia transformation is independent of treatment, although it seems advisable to treat leukoplakia with or without dysplasia.

  20. Effect of phosphate buffer saline on coronal leakage of mineral trioxide aggregate.

    Science.gov (United States)

    Parirokh, Masoud; Askarifard, Sara; Mansouri, Shahla; Haghdoost, Ali A; Raoof, Maryam; Torabinejad, Mahmoud

    2009-06-01

    This study was carried out to compare the bacterial leakage of MTA used as a root-end filling material when it was kept in phosphate buffer saline (PBS) or normal saline. In this study, 72 freshly extracted teeth were used. The roots were randomly divided into four experimental groups of 15 each (groups I and II gutta-percha obturation + MTA, groups III and IV only MTA) and two positive and negative control groups of six each. The samples in groups I and III were kept in normal saline for 1 month while the samples in groups II and IV were kept in PBS. Enterococcus faecalis was used for determination of the bacterial penetration. Kaplan-Meier survival curve and chi(2) test were employed for data analysis. The obturated samples with root-end filling showed significantly longer duration of resistance to bacterial penetration than canals without obturation (P < 0.05). The roots that were placed in PBS (groups II and IV) showed significantly less bacterial penetration in comparison with the roots that were stored in normal saline (P < 0.05). In conclusion, MTA, which acts as a bioactive material, should be placed in a synthetic tissue fluid before any leakage evaluation.

  1. Subcellular localization of APE1/Ref-1 in human hepatocellular carcinoma: possible prognostic significance.

    Science.gov (United States)

    Di Maso, Vittorio; Avellini, Claudio; Crocè, Lory Saveria; Rosso, Natalia; Quadrifoglio, Franco; Cesaratto, Laura; Codarin, Erika; Bedogni, Giorgio; Beltrami, Carlo Alberto; Tell, Gianluca; Tiribelli, Claudio

    2007-01-01

    APE1/Ref-1, normally localized in the nucleus, is a regulator of the cellular response to oxidative stress. Cytoplasmic localization has been observed in several tumors and correlates with a poor prognosis. Because no data are available on liver tumors, we investigated APE1/Ref-1 subcellular localization and its correlation with survival in 47 consecutive patients undergoing hepatocellular carcinoma (HCC) resection. APE1/Ref-1 expression was determined by immunohistochemistry in HCC and surrounding liver cirrhosis (SLC) and compared with normal liver tissue. Survival probability was evaluated using Kaplan-Meier curves (log-rank test) and Cox regression. Cytoplasmic expression of APE1/Ref-1 was significantly higher in HCC than in SLC (P = 0.00001); normal liver showed only nuclear reactivity. Patients with poorly differentiated HCC showed a cytoplasmic expression three times higher than those with well-differentiated HCC (P = 0.03). Cytoplasmic localization was associated with a median survival time shorter than those with negative cytoplasmic reactivity (0.44 compared with 1.64 years, P = 0.003), and multivariable analysis confirmed that cytoplasmic APE1/Ref-1 localization is a predictor of survival. Cytoplasmic expression of APE1/Ref-1 is increased in HCC and is associated with a lower degree of differentiation and a shorter survival time, pointing to the use of the cytoplasmic localization of APE1/Ref-1 as a prognostic marker for HCC.

  2. Algebraic curves and one-dimensional fields

    CERN Document Server

    Bogomolov, Fedor

    2002-01-01

    Algebraic curves have many special properties that make their study particularly rewarding. As a result, curves provide a natural introduction to algebraic geometry. In this book, the authors also bring out aspects of curves that are unique to them and emphasize connections with algebra. This text covers the essential topics in the geometry of algebraic curves, such as line and vector bundles, the Riemann-Roch Theorem, divisors, coherent sheaves, and zeroth and first cohomology groups. The authors make a point of using concrete examples and explicit methods to ensure that the style is clear an

  3. Orthogonal Polynomials and $S$-curves

    CERN Document Server

    Rakhmanov, E A

    2011-01-01

    This paper is devoted to a study of $S$-curves, that is systems of curves in the complex plane whose equilibrium potential in a harmonic external field satisfies a special symmetry property ($S$-property). Such curves have many applications. In particular, they play a fundamental role in the theory of complex (non-hermitian) orthogonal polynomials. One of the main theorems on zero distribution of such polynomials asserts that the limit zero distribution is presented by an equilibrium measure of an $S$-curve associated with the problem if such a curve exists. These curves are also the starting point of the matrix Riemann-Hilbert approach to srtong asymptotics. Other approaches to the problem of strong asymptotics (differential equations, Riemann surfaces) are also related to $S$-curves or may be interpreted this way. Existence problem $S$-curve in a given class of curves in presence of a nontrivial external field presents certain challenge. We formulate and prove a version of existence theorem for the case whe...

  4. Factors as predictors for thoracic and thoracolumbar/lumbar structural curves in adolescent idiopathic scoliosis

    Institute of Scientific and Technical Information of China (English)

    CHEN Zi-qiang; ZHAO Yong-fei; HE Shi-sheng; WANG Chuan-feng; ZHANG Jing-tao; ZHAO Ying-chuan; YANG Chang-wei; LI Ming

    2012-01-01

    Background Recent studies have demonstrated that the Lenke system is relatively efficient and consistent in classifying scoliosis curves.Basically,fusion should include the main curve and the structural minor curve.The criteria for defining the structural minor curve were established to help guide these decision-making process.The present study was designed to investigate predictors of the structural curve,and see whether it was possible to prevent the formation of the structural curve by interfering with influencing factors to decrease the fusion level.Methods Age,gender,Cobb angle,Perdriolle rotation,Risser sign and the number of vertebrae included in the curve,brace treatment,and curve location were recorded in 145 idiopathic scoliosis patients from July 2001 to January 2007.The patients were divided into two groups:structural and non-structural groups.Demographics and baseline characteristics were compared between the two groups as an initial screen.Logistic regression was used to analyze factors affecting the minor curve to become the structural curve.Results Compared with the non-structural group,the structural group had a higher Cobb angle ((51.34±13.61)° vs.(34.20±7.21)°,P <0.001),bending angle ((33.94±9.92)° vs.(8.46±5.56)°,P <0.001) and curve rotation ((23.25±12.86)° vs.(14.21±8.55) °,P <0.001),and lower flexibility ((33.48±12.53)% vs.(75.50±15.52)%,P <0.001).There was no significant difference in other parameters between the two groups.The results of the Logistic regression analysis showed that the Cobb angle (OR:9.921,P <0.001) and curve location (OR.4.119,P=0.016) were significant predictors of structural curve in adolescent idiopathic scoliosis.Every 10° change of Cobb angle increased the possibility of turning the minor curve into the structural curve by 10-fold.And thoracic curve showed,on the average,the possibility of becoming the structural curve about 4-fold more often than did the thoracolumbar/lumbar curve

  5. The universal rotation curve of dwarf disk galaxies

    CERN Document Server

    Karukes, Ekaterina V

    2016-01-01

    We use the concept of the spiral rotation curves universality (see Parsic et al. 1996) to investigate the luminous and dark matter properties of the dwarf disk galaxies in the local volume (size $\\sim11$ Mpc). Our sample includes 36 objects with rotation curves carefully selected from the literature. We find that, despite the large variations of our sample in luminosities ($\\sim$ 2 of dex), the rotation curves in specifically normalized units, look all alike and lead to the lower-mass version of the universal rotation curve of spiral galaxies found in Parsic et al. 1996. We mass model $V(R/R_{opt})/V_{opt}$, the double normalized universal rotation curve of dwarf disk galaxies: the results show that these systems are totally dominated by dark matter whose density shows a core size between 2 and 3 stellar disk scale lengths. Similar to galaxies of different Hubble types and luminosities, the core radius $r_0$ and the central density $\\rho_0$ of the dark matter halo of these objects are related by $ \\rho_0 r_0 ...

  6. Risk Aversion in Game Shows

    DEFF Research Database (Denmark)

    2008-01-01

    We review the use of behavior from television game shows to infer risk attitudes. These shows provide evidence when contestants are making decisions over very large stakes, and in a replicated, structured way. Inferences are generally confounded by the subjective assessment of skill in some games......, and the dynamic nature of the task in most games. We consider the game shows Card Sharks, Jeopardy!, Lingo, and finally Deal Or No Deal. We provide a detailed case study of the analyses of Deal Or No Deal, since it is suitable for inference about risk attitudes and has attracted considerable attention....

  7. Measuring performance at trade shows

    DEFF Research Database (Denmark)

    Hansen, Kåre

    2004-01-01

    Trade shows is an increasingly important marketing activity to many companies, but current measures of trade show performance do not adequately capture dimensions important to exhibitors. Based on the marketing literature's outcome and behavior-based control system taxonomy, a model is built...... that captures a outcome-based sales dimension and four behavior-based dimensions (i.e. information-gathering, relationship building, image building, and motivation activities). A 16-item instrument is developed for assessing exhibitors perceptions of their trade show performance. The paper presents evidence...

  8. Leptogenesis from loop effects in curved spacetime

    Science.gov (United States)

    McDonald, Jamie I.; Shore, Graham M.

    2016-04-01

    We describe a new mechanism — radiatively-induced gravitational leptogenesis — for generating the matter-antimatter asymmetry of the Universe. We show how quantum loop effects in C and CP violating theories cause matter and antimatter to propagate differently in the presence of gravity, and prove this is forbidden in flat space by CPT and translation symmetry. This generates a curvature-dependent chemical potential for leptons, allowing a matter-antimatter asymmetry to be generated in thermal equilibrium in the early Universe. The time-dependent dynamics necessary for leptogenesis is provided by the interaction of the virtual self-energy cloud of the leptons with the expanding curved spacetime background, which violates the strong equivalence principle and allows a distinction between matter and antimatter. We show here how this mechanism is realised in a particular BSM theory, the see-saw model, where the quantum loops involve the heavy sterile neutrinos responsible for light neutrino masses. We demonstrate by explicit computation of the relevant two-loop Feynman diagrams how the size of the radiative corrections relevant for leptogenesis becomes enhanced by increasing the mass hierarchy of the sterile neutrinos, and show how the induced lepton asymmetry may be sufficiently large to play an important rôle in determining the baryon-to-photon ratio of the Universe.

  9. Leptogenesis from loop effects in curved spacetime

    Energy Technology Data Exchange (ETDEWEB)

    McDonald, Jamie I.; Shore, Graham M. [Department of Physics, Swansea University,Singleton Park, Swansea, SA2 8PP (United Kingdom)

    2016-04-05

    We describe a new mechanism — radiatively-induced gravitational leptogenesis — for generating the matter-antimatter asymmetry of the Universe. We show how quantum loop effects in C and CP violating theories cause matter and antimatter to propagate differently in the presence of gravity, and prove this is forbidden in flat space by CPT and translation symmetry. This generates a curvature-dependent chemical potential for leptons, allowing a matter-antimatter asymmetry to be generated in thermal equilibrium in the early Universe. The time-dependent dynamics necessary for leptogenesis is provided by the interaction of the virtual self-energy cloud of the leptons with the expanding curved spacetime background, which violates the strong equivalence principle and allows a distinction between matter and antimatter. We show here how this mechanism is realised in a particular BSM theory, the see-saw model, where the quantum loops involve the heavy sterile neutrinos responsible for light neutrino masses. We demonstrate by explicit computation of the relevant two-loop Feynman diagrams how the size of the radiative corrections relevant for leptogenesis becomes enhanced by increasing the mass hierarchy of the sterile neutrinos, and show how the induced lepton asymmetry may be sufficiently large to play an important rôle in determining the baryon-to-photon ratio of the Universe.

  10. Spitzer Space Telescope Mid-IR Light Curves of Neptune

    Science.gov (United States)

    Stauffer, John; Marley, Mark S.; Gizis, John E.; Rebull, Luisa; Carey, Sean J.; Krick, Jessica; Ingalls, James G.; Lowrance, Patrick; Glaccum, William; Kirkpatrick, J. Davy; Simon, Amy A.; Wong, Michael H.

    2016-11-01

    We have used the Spitzer Space Telescope in 2016 February to obtain high cadence, high signal-to-noise, 17 hr duration light curves of Neptune at 3.6 and 4.5 μm. The light curve duration was chosen to correspond to the rotation period of Neptune. Both light curves are slowly varying with time, with full amplitudes of 1.1 mag at 3.6 μm and 0.6 mag at 4.5 μm. We have also extracted sparsely sampled 18 hr light curves of Neptune at W1 (3.4 μm) and W2 (4.6 μm) from the Wide-feld Infrared Survey Explorer (WISE)/NEOWISE archive at six epochs in 2010-2015. These light curves all show similar shapes and amplitudes compared to the Spitzer light curves but with considerable variation from epoch to epoch. These amplitudes are much larger than those observed with Kepler/K2 in the visible (amplitude ˜0.02 mag) or at 845 nm with the Hubble Space Telescope (HST) in 2015 and at 763 nm in 2016 (amplitude ˜0.2 mag). We interpret the Spitzer and WISE light curves as arising entirely from reflected solar photons, from higher levels in Neptune’s atmosphere than for K2. Methane gas is the dominant opacity source in Neptune’s atmosphere, and methane absorption bands are present in the HST 763 and 845 nm, WISE W1, and Spitzer 3.6 μm filters.

  11. Determination of the human spine curve based on laser triangulation.

    Science.gov (United States)

    Poredoš, Primož; Čelan, Dušan; Možina, Janez; Jezeršek, Matija

    2015-02-05

    The main objective of the present method was to automatically obtain a spatial curve of the thoracic and lumbar spine based on a 3D shape measurement of a human torso with developed scoliosis. Manual determination of the spine curve, which was based on palpation of the thoracic and lumbar spinous processes, was found to be an appropriate way to validate the method. Therefore a new, noninvasive, optical 3D method for human torso evaluation in medical practice is introduced. Twenty-four patients with confirmed clinical diagnosis of scoliosis were scanned using a specially developed 3D laser profilometer. The measuring principle of the system is based on laser triangulation with one-laser-plane illumination. The measurement took approximately 10 seconds at 700 mm of the longitudinal translation along the back. The single point measurement accuracy was 0.1 mm. Computer analysis of the measured surface returned two 3D curves. The first curve was determined by manual marking (manual curve), and the second was determined by detecting surface curvature extremes (automatic curve). The manual and automatic curve comparison was given as the root mean square deviation (RMSD) for each patient. The intra-operator study involved assessing 20 successive measurements of the same person, and the inter-operator study involved assessing measurements from 8 operators. The results obtained for the 24 patients showed that the typical RMSD between the manual and automatic curve was 5.0 mm in the frontal plane and 1.0 mm in the sagittal plane, which is a good result compared with palpatory accuracy (9.8 mm). The intra-operator repeatability of the presented method in the frontal and sagittal planes was 0.45 mm and 0.06 mm, respectively. The inter-operator repeatability assessment shows that that the presented method is invariant to the operator of the computer program with the presented method. The main novelty of the presented paper is the development of a new, non-contact method

  12. Body size and longitudinal body weight changes do not increase mortality in incident peritoneal dialysis patients of the Brazilian peritoneal dialysis multicenter study

    Directory of Open Access Journals (Sweden)

    Natália Maria da Silva Fernandes

    2013-01-01

    Full Text Available OBJECTIVES: To determine the roles of body size and longitudinal body weight changes in the survival of incident peritoneal dialysis patients. PATIENTS AND METHODS: Patients (n = 1911 older than 18 years of age recruited from 114 dialysis centers (Dec/ 2004-Oct/2007 and participating in the Brazilian Peritoneal Dialysis Multicenter Cohort Study were included. Clinical and laboratory data were collected monthly (except if the patient received a transplant, recovered renal function, was transferred to hemodialysis, or died. RESULTS: Survival analyses were performed using Kaplan-Meier survival curves and Cox proportional hazards. Total follow-up was 34 months. The mean age was 59 years (54% female. The weight category percentages were as follows: underweight: 8%; normal: 51%; overweight: 29%; and obese 12%. The multivariate model showed a higher risk of death for a body mass index 30 kg/m². Patients were divided into five categories according to quintiles of body weight changes during the first year of dialysis: +7.1%. Patients in the lowest quintile had significantly higher mortality, whereas no negative impact was observed in the other quintiles. CONCLUSION: These findings suggest that overweight/obesity and a positive body weight variation during the first year of peritoneal dialysis therapy do not increase mortality in incident dialysis patients in Brazil.

  13. Low incidence but poor prognosis of complicated coeliac disease: a retrospective multicentre study.

    Science.gov (United States)

    Biagi, Federico; Gobbi, Paolo; Marchese, Alessandra; Borsotti, Edoardo; Zingone, Fabiana; Ciacci, Carolina; Volta, Umberto; Caio, Giacomo; Carroccio, Antonio; Ambrosiano, Giuseppe; Mansueto, Pasquale; Corazza, Gino R

    2014-03-01

    Coeliac disease is a chronic enteropathy characterized by an increased mortality caused by its complications, mainly refractory coeliac disease, small bowel carcinoma and abdominal lymphoma. Aim of the study was to study the epidemiology of complications in patients with coeliac disease. Retrospective multicenter case-control study based on collection of clinical and laboratory data. The incidence of complicated coeliac disease was studied among coeliac patients directly diagnosed in four Italian centres. Patients referred to these centres after a diagnosis of coeliac disease and/or complicated coeliac disease in other hospitals were therefore excluded. Between 1/1999 and 10/2011, 1840 adult coeliac patients were followed up for 7364.3 person-years. Fourteen developed complications. Since five patients died, at the end of the observation period (10/2011), the prevalence of complicated coeliac disease was 9/1835 (1/204, 0.49%, 95% CI 0.2-0.9%). The annual incidence of complicated coeliac disease in the study period was 14/7364 (0.2%, 95% CI 0.1-0.31%). Although complications tend to occur soon after the diagnosis of coeliac disease, Kaplan-Meier curve analysis showed that they can actually occur at any time after the diagnosis of coeliac disease. Complications of coeliac disease in our cohort were quite rare, though characterised by a very high mortality. Copyright © 2013 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

  14. Pendidikan Kesehatan Reproduksi Formal dan Hubungan Seksual Pranikah Remaja Indonesia

    Directory of Open Access Journals (Sweden)

    Anggriyani Wahyu Pinandari

    2015-08-01

    by sexual and reproductive revolution. Potential problems in this era are the increase of premarital sexual behavior, unwanted pregnancy, sexual transmitted infection and drug abuse. This study aimed to examine the influence of formal reproductive health education to delay premarital sexual intercourse among Indonesian teenagers and young adults. Cross sectional study analyzed as retrospective cohort used data of Indonesian Teenage Reproductive Health Survey in 2012 (10,980 men and 8,902 women. Effects of formal reproductive health education to delay sexual intercourse behavior was analyzed using kaplan meier curve, log-rank test, and chi square test, meanwhile multivariat analysis used logistic regression. All tests used confidence interval 95% and p value = 0.05. Results of survival analysis of abstinence committing sexual intercourse showed that teenagers who didn’t receive or only receive one of reproductive health education materials had bigger hazard ratio (respectively 1.55 (CI=1.32 – 1.82; 0.99 (CI=0.86 – 1.15 and 2.26 (CI=1.43 – 3.56. Receiving complete information gave longer abstinence time. Drug abuse, smoking, alcohol, men, aged between 20 – 24 years old and poor were more likely to commit premarital sexual intercourse. Receipt of reproductive health information at formal education level may delay the occurrence of premarital sexual intercourse.

  15. Association between expression of DNA mismatch repair genes and clinical features and prognosis of patients with radical resection of colon cancer.

    Science.gov (United States)

    Wang, J B; Ma, D L; Li, J Y; Sun, Q D; Liu, Y E

    2016-08-19

    The aim of this study was to investigate the clinical significance of the expression of DNA mismatch repair (MMR) genes in patients subjected to radical surgical removal of colon cancer, as well as their correlation with disease prognosis. Ninety stage II and III colon cancer patients who received laparoscopic radical resection of colon cancer at our hospital were recruited in this study. The expression of hMLH1, hMSH2, hMSH6, and hPMS2 in the resected tumor tissues was examined by SP immunohistochemistry, in order to analyze the relationship between defective DNA MMR (dMMR) and the clinico-pathological features and prognosis of colon cancer. Patients were followed up over a period of 5-35 months, and the Kaplan-Meier survival curve was plotted. dMMR was confirmed in 27 subjects (30.0%), among whom recurrence with metastasis and death was reported in 5 (18.5%) and 2 (7.4%) patients, respectively. The remaining 63 subjects displayed proficient DNA MMR (pMMR); among these, 19 (30.2%) and 7 (11.1%) recurrences with metastasis and death were reported, respectively. dMMR showed no significant correlation with gender, age, or therapeutic modality (P > 0.05), but was significantly correlated with the degree of differentiation, tumor location, number of resected lymph nodes, presence of ileus, and TNM stage (P colon cancers.

  16. BRG1 is a prognostic marker and potential therapeutic target in human breast cancer.

    Directory of Open Access Journals (Sweden)

    Jin Bai

    Full Text Available BRG1, a core component of the SWI/SNF chromatin-remodeling complex, has been implicated in cancer development; however, the biological significance of BRG1 in breast cancer remains unknown. We explored the role of BRG1 in human breast cancer pathogenesis. Using tissue microarray and immunohistochemistry, we evaluated BRG1 staining in 437 breast cancer specimens and investigated its role in breast cancer cell proliferation, migration and invasion. Our Kaplan-Meier survival curves showed that high BRG1 expression is inversely correlated with both overall (P = 0.000 and disease-specific (P = 0.000 5-year patient survival. Furthermore, we found that knockdown of BRG1 by RNA interference markedly inhibits cell proliferation and causes cessation of cell cycle. This reduced cell proliferation is due to G1 phase arrest as cyclin D1 and cyclin E are diminished whereas p27 is upregulated. Moreover, BRG1 depletion induces the expression of TIMP-2 but reduces MMP-2, thereby inhibiting the ability of cells to migrate and to invade. These results highlight the importance of BRG1 in breast cancer pathogenesis and BRG1 may serve as a prognostic marker as well as a potentially selective therapeutic target.

  17. EGFR Expression and KRAS and BRAF Mutational Status in Intestinal-Type Sinonasal Adenocarcinoma

    Directory of Open Access Journals (Sweden)

    Valérie Costes

    2013-03-01

    Full Text Available Accumulation of molecular alterations, including EGFR overexpression and mutations in KRAS and BRAF, contribute to colorectal carcinogenesis. Since intestinal-type adenocarcinoma (ITAC of the nasal cavity and paranasal sinus has morphologic and phenotypic features that are usually indistinguishable from colorectal cancer (CRC, it is likely that both tumor types share equivalent genetic alterations. Data from a series of 43 patients treated surgically for ITAC in Montpellier, France between November 1998 and December 2012 were collected. Tumors were characterized for mutations in KRAS and BRAF as well as EGFR overexpression. Kaplan-Meier survival curves were constructed using overall survival as the primary end points. Patient survival was analyzed using the hazards ratio. Twenty seven tumors (63% showed EGFR positivity and 30% exhibited a high expression level (+2/+3. KRAS mutations were detected in 43% of cases. BRAF mutations were identified in 3.6% of specimens. Patients with age superior to 60 years, metastatic status, and KRAS mutations had significant overall survival values (p = 0.026, p = 0.001 and p = 0.03, respectively. Our results indicate that KRAS mutations and EGFR expression are frequent in ITAC and that KRAS mutations predict good patient prognosis in ITAC. Finally, EGFR directed molecular treatments could be investigated in a subset of patients affected by ITAC.

  18. The use of coronary stent in hepatic artery stenosis after orthotopic liver transplantation

    Energy Technology Data Exchange (ETDEWEB)

    Huang Mingsheng [Department of Radiology, the Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510630, Guangdong Province (China); Shan Hong [Department of Radiology, the Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510630, Guangdong Province (China)]. E-mail: gzshsums@public.guangzhou.gd.cn; Jiang Zaibo [Department of Radiology, the Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510630, Guangdong Province (China); Li Zhengran [Department of Radiology, the Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510630, Guangdong Province (China); Zhu Kangshun [Department of Radiology, the Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510630, Guangdong Province (China); Guan Shouhai [Department of Radiology, the Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510630, Guangdong Province (China); Qian Jiesheng [Department of Radiology, the Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510630, Guangdong Province (China); Chen Guihua [Transplantation Center, the Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510630, Guangdong Province (China); Lu Minqiang [Transplantation Center, the Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510630, Guangdong Province (China); Yang Yang [Transplantation Center, the Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510630, Guangdong Province (China)

    2006-12-15

    Purpose: This retrospective study was undertaken to evaluate the effectiveness of coronary stent placement in hepatic artery stenosis after orthotopic liver transplantation (OLT). Materials and methods: Of 430 consecutive adult orthotopic liver transplant recipients between November 2003 and September 2005, 17 had hepatic artery stenosis (HAS). Fourteen of them underwent coronary stent placement in the HAS. The technical results, complications, hepatic artery patency and clinical outcome were reviewed. Results: Technical and immediate success was 100%. After a mean follow-up of 159.4 days (range, 9-375 days), all patients obtained patent hepatic arteries except 2 patients occurred hepatic artery restenoses at 26 and 45 days after stent placement, respectively. Kaplan-Meier curve of patency showed cumulated stent patency at 3, 6, and 12 months of 78%, 58% and 45%, respectively. During the follow-up, 8 patients survived, 5 died of septic multiple-organ failure, 1 received retransplantation because of refractory biliary infection. Hepatic artery dissection induced by a guiding catheter occurred in one patient and was successfully treated with a coronary stent. Conclusion: Hepatic artery stenosis after OLT can be successfully treated with coronary stent placement with low complication rate and an acceptable 1-year hepatic artery patency rate.

  19. Delirium: A predictor of mortality in the elderly

    Directory of Open Access Journals (Sweden)

    Matías González

    2005-09-01

    Full Text Available The frequency of delirium in elderly inpatients is high, resulting in poor hospital outcomes. The objective of this study is to assess whether delirium is an independent predictor for mortality over a three-month period. Methods: Prospective, observational study in a cohort of 171 inpatients aged over 65 years. Presence of delirium and/or dementia, severity of delirium and incapacity due to illness were assessed at baseline using DSM-IV diagnostic criteria, the Confusion Assessment Method (CAM, the MMSE, the Delirium Rating Scale (DRS and the Karnofsky Performance Status (KPS. Mortality rates were evaluated over a three-month follow-up period after enrollment. Kaplan-Meier survival curves were constructed and the adjusted effect of a set of covariates was evaluated with the Cox multiple regression analysis. Results: By 3 months after enrollment, 34.4% of the patients with delirium died, compared with 16.5% of those without delirium. The survival analysis shows a statistically significant difference between the two groups (log-rank=11.92; d.f.=1; P=0.0006. After adjustment for covariates, delirium was found to be independently associated with higher mortality. Conclusions: Delirium was found to be an independent marker for mortality in older medical patients over a three-month follow-up.

  20. Lower Urinary Tract Symptoms Are Associated with Increased Risk of Dementia among the Elderly: A Nationwide Study

    Directory of Open Access Journals (Sweden)

    Chi-Hsiang Chiang

    2015-01-01

    Full Text Available Studies show a strong association between dementia and lower urinary tract symptoms (LUTS. The aim of this study was to investigate whether LUTS are a risk factor for cognitive impairment. We enrolled 50-year-old and older subjects with LUTS (LUTS[+] (n=6801 and controls without LUTS (LUTS[−] (n=20,403 from Taiwan’s National Health Insurance Research Database. LUTS, dementia, and other confounding factors are defined by International Classification of Diseases, Ninth Revision, Clinical Modification Codes. Participants were recruited from 2000 to 2004 and then followed up until death or the end of 2011. The outcome was the onset of dementia, which was assessed using Poisson regression analysis, Cox hazards models, and Kaplan-Meier survival curves. The incidence of dementia was significantly higher in the LUTS[+] group than in the LUTS[−] group (124.76 versus 77.59/1000 person-years. The increased risk of dementia related to LUTS remained significant after adjustment for potential confounders (adjusted hazard ratio (AHR: 1.61, 95% confidence interval (CI 1.47–1.76, P<0.0001 and higher than that related to cerebrovascular disease (AHR: 1.43, 95% CI 1.26–1.61, P<0.0001. The outcome suggests the need for early screening and appropriate intervention to help prevent cognitive impairment of patients with LUTS.

  1. Nomogram for Predicting Time to Death After Withdrawal of Life-Sustaining Treatment in Patients With Devastating Neurological Injury.

    Science.gov (United States)

    He, X; Xu, G; Liang, W; Liu, B; Xu, Y; Luan, Z; Lu, Y; Ko, D S C; Manyalich, M; Schroder, P M; Guo, Z

    2015-08-01

    Reliable prediction of time of death after withdrawal of life-sustaining treatment in patients with devastating neurological injury is crucial to successful donation after cardiac death. Herein, we conducted a study of 419 neurocritical patients who underwent life support withdrawal at four neurosurgical centers in China. Based on a retrospective cohort, we used multivariate Cox regression analysis to identify prognostic factors for patient death, which were then integrated into a nomogram. The model was calibrated and validated using data from an external retrospective cohort and a prospective cohort. We identified 10 variables that were incorporated into a nomogram. The C-indexes for predicting the 60-min death probability in the training, external validation and prospective validation cohorts were 0.96 (0.93-0.98), 0.94 (0.91-0.97), and 0.99 (0.97-1.00), respectively. The calibration plots after WLST showed an optimal agreement between the prediction of time to death by the nomogram and the actual observation for all cohorts. Then we identified 22, 26 and 37 as cut-points for risk stratification into four groups. Kaplan-Meier curves indicated distinct prognoses between patients in the different risk groups (p death donors in neurocritical patients in a Chinese population.

  2. Prognostic significance of clusterin expression in advanced-stage cervical cancer treated with curative intended radiotherapy.

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    Watari, Hidemichi; Kinoshita, Rumiko; Han, Yimin; Wang, Lei; Hosaka, Masayoshi; Taguchi, Hiroshi; Tsuchiya, Kazuhiko; Tanaka, Shinya; Shirato, Hiroki; Sakuragi, Noriaki

    2012-03-01

    Overexpression of clusterin (CLU), an antiapoptotic molecule, has been reported to induce resistance to radiotherapy (RT) in a variety of cancer cell types. The aim of this study was to evaluate the significance of CLU expression to predict survival of patients with advanced-stage cervical cancer who received curative intended RT. Biopsy tissue specimens of advanced-stage cervical cancer before curative intended RT were obtained from 34 patients who were treated at Hokkaido University Hospital between 1998 and 2008 and whose complete medical records were available. The expression of CLU protein was analyzed by immunohistochemistry. Findings were evaluated in relation to several clinicopathological factors. Survival analyses were performed using the Kaplan-Meier curves and the log-rank test. Independent prognostic factors were determined by multivariate Cox regression analysis. Clusterin protein was mainly present in the cytoplasm of cervical cancer cells. The expression of CLU protein in cervical cancer tissues before curative intended RT was not significantly related to any clinicopathological factors analyzed, including age, clinical stage, histologic type, and response to RT. Univariate analysis on prognostic factors showed that histologic type (P = 0.001), and CLU expression (P = 0.02) were related to survival. Multivariate analysis revealed that both histologic type (P = 0.002), and CLU expression (P = 0.02) were independent prognostic factors for overall survival. We conclude that CLU could be a new molecular marker to predict overall survival of patients with advanced-stage cervical cancer treated with curative intended RT.

  3. Relapse risk assessment of transplantation for patients with chronic myeloid leukaemia

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    Objective To analyse the risk factors of relapse before bone marrow transplantation (BMT) and to present the prognostic information as good as possible.Methods A total of 3142 patients, who underwent the allogeneic blood or bone marrow tran splantation between 1989 and 1997 and were documented in the European Group for Blood and Marrow transplantation (EBMT), were included. Six possible risk factors including type of donor, stage of disease, age, gender, donor@#-recipient sex co mbination and the waiting time from diagnosis to transplation of relapse were co nsidered. The time to relapse was analysed by Kaplan-Meier curves and Coxregre ssion with stratification on prognostic factors that did not satisfy the Proport ional Hazard Assumption.Results An amount of 447 patients relapsed out of all 3142 patients. The relapse rate was 14.2%. Type of donor and stage of disease showed a clear prognostic effect, but failed the proportional hazard assumption. Therefore, the data were stratified on the combination of type of donor and stage of disease. Within these strata a n additional significant effect of age could be observed. Relative risk of age ≥40 vs age <40 was 1.32 (95% confidence interval 1.09-1.59). The prognostic model is summarized graphically.Conclusions The combination of type of donor, stage of disease and age of recipient at transplantation are important prognostic factors for relapse after BMT.

  4. Clinical evaluation of therapeutic success in rabbits with suspected encephalitozoonosis.

    Science.gov (United States)

    Sieg, Jessica; Hein, Jutta; Jass, Ariane; Sauter-Louis, Carola; Hartmann, Katrin; Fischer, Andrea

    2012-06-01

    Between 2000 and 2008, 95 rabbits with suspected encephalitozoonosis and neurological symptoms were treated at the Clinic of Small Animal Medicine, Ludwig Maximilian University Munich. Standard treatment consisted of oxytetracycline (from 2000 to 2003; n=50) or fenbendazole and oxytetracycline (from 2004 to 2008; n=45), and the rabbits were randomly assigned to treatment groups with or without dexamethasone. Each therapeutic regime was given for 10 days, with fluids, B vitamins and nutritional support added as needed. Therapeutic success was evaluated by assessing the survival rate on day 10, the neurological score of the surviving rabbits and Kaplan-Meier curves for long-term survival past 10 days. Inclusion of fenbendazole in the treatment protocol was associated with increased survival rates on day 10 (p=0.043), better neurological scores (p=0.008), and improved long-term survival (p=0.025) based on the results of univariate analyses. Treatment with dexamethasone showed no effect on neurological score or on short- or long-term survival. The study did not provide any evidence that dexamethasone is an effective component of the treatment scheme.

  5. Survival of a cohort of women with cervical cancer diagnosed in a Brazilian cancer center

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    Claudio Calazan do Carmo

    2011-08-01

    Full Text Available OBJECTIVE: To assess overall survival of women with cervical cancer and describe prognostic factors associated. METHODS: A total of 3,341 cases of invasive cervical cancer diagnosed at the Brazilian Cancer Institute, Rio de Janeiro, southeastern Brazil, between 1999 and 2004 were selected. Clinical and pathological characteristics and follow-up data were collected. There were performed a survival analysis using Kaplan-Meier curves and a multivariate analysis through Cox model. RESULTS: Of all cases analyzed, 68.3% had locally advanced disease at the time of diagnosis. The 5-year overall survival was 48%. After multivariate analysis, tumor staging at diagnosis was the single variable significantly associated with prognosis (p<0.001. There was seen a dose-response relationship between mortality and clinical staging, ranging from 27.8 to 749.6 per 1,000 cases-year in women stage I and IV, respectively. CONCLUSIONS: The study showed that early detection through prevention programs is crucial to increase cervical cancer survival.

  6. PREDICTIVE FACTORS FOR THE PROGRESSION OF CHRONIC CHAGAS CARDIOMYOPATHY IN PATIENTS WITHOUT LEFT VENTRICULAR DYSFUNCTION

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    Silvana de Araújo SILVA

    2015-04-01

    Full Text Available The identification of predictors for the progression of chronic Chagas cardiomyopathy (CCC is essential to ensure adequate patient management. This study looked into a non-concurrent cohort of 165 CCC patients between 1985 and 2010 for independent predictors for CCC progression. The outcomes were worsening of the CCC scores and the onset of left ventricular dysfunction assessed by means of echo-Doppler cardiography. Patients were analyzed for social, demographic, epidemiologic, clinical and workup-related variables. A descriptive analysis was conducted, followed by survival curves based on univariate (Kaplan-Meier and Cox’s univariate model and multivariate (Cox regression model analysis. Patients were followed from two to 20 years (mean: 8.2. Their mean age was 44.8 years (20-77. Comparing both iterations of the study, in the second there was a statistically significant increase in the PR interval and in the QRS duration, despite a reduction in heart rates (Wilcoxon < 0.01. The predictors for CCC progression in the final regression model were male gender (HR = 2.81, Holter monitoring showing pauses equal to or greater than two seconds (HR = 3.02 increased cardiothoracic ratio (HR = 7.87 and time of use of digitalis (HR = 1.41. Patients with multiple predictive factors require stricter follow-up and treatment.

  7. AKT1 and BRAF mutations in pediatric aggressive fibromatosis.

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    Meazza, Cristina; Belfiore, Antonino; Busico, Adele; Settanni, Giulio; Paielli, Nicholas; Cesana, Luca; Ferrari, Andrea; Chiaravalli, Stefano; Massimino, Maura; Gronchi, Alessandro; Colombo, Chiara; Pilotti, Silvana; Perrone, Federica

    2016-06-01

    Aside from the CTNNB1 and adenomatous polyposis coli (APC) mutations, the genetic profile of pediatric aggressive fibromatosis (AF) has remained poorly characterized. The aim of this study was to shed more light on the mutational spectrum of pediatric AF, comparing it with its adult counterpart, with a view to identifying biomarkers for use as prognostic factors or new potential therapeutic targets. CTNNB1, APC, AKT1, BRAF TP53, and RET Sanger sequencing and next-generation sequencing (NGS) with the 50-gene Ion AmpliSeq Cancer Hotspot Panel v2 were performed on formalin-fixed samples from 28 pediatric and 33 adult AFs. The prognostic value of CTNNB1, AKT1, and BRAF mutations in pediatric AF patients was investigated. Recurrence-free survival (RFS) curves were estimated with the Kaplan-Meier method and statistical comparisons were drawn using the log-rank test. In addition to the CTNNB1 mutation (64%), pediatric AF showed AKT1 (31%), BRAF (19%), and TP53 (9%) mutations, whereas only the CTNNB1 mutation was found in adult AF. The polymorphism Q472H VEGFR was identified in both pediatric (56%) and adult (40%) AF. Our results indicate that the mutational spectrum of pediatric AF is more complex than that of adult AF, with multiple gene mutations involving not only CTNNB1 but also AKT1 and BRAF. This intriguing finding may have clinical implications and warrants further investigations. © 2016 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

  8. Deferiprone versus deferoxamine in sickle cell disease: results from a 5-year long-term Italian multi-center randomized clinical trial.

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    Calvaruso, Giusi; Vitrano, Angela; Di Maggio, Rosario; Ballas, Samir; Steinberg, Martin H; Rigano, Paolo; Sacco, Massimiliano; Telfer, Paul; Renda, Disma; Barone, Rita; Maggio, Aurelio

    2014-12-01

    Blood transfusion and iron chelation currently represent a supportive therapy to manage anemia, vasculopathy and vaso-occlusion crises in Sickle-Cell-Disease. Here we describe the first 5-year long-term randomized clinical trial comparing Deferiprone versus Deferoxamine in patients with Sickle-Cell-Disease. The results of this study show that Deferiprone has the same effectiveness as Deferoxamine in decreasing body iron burden, measured as repeated measurements of serum ferritin concentrations on the same patient over 5-years and analyzed according to the linear mixed-effects model (LMM) (p=0.822). Both chelators are able to decrease, significantly, serum ferritin concentrations, during 5-years, without any effect on safety (p=0.005). Moreover, although the basal serum ferritin levels were higher in transfused compared with non-transfused group (p=0.031), the changes over time in serum ferritin levels were not statistically significantly different between transfused and non-transfused cohort of patients (p=0.389). Kaplan-Meier curve, during 5-years of study, suggests that Deferiprone does not alter survival in comparison with Deferoxamine (p=0.38). In conclusion, long-term iron chelation therapy with Deferiprone was associated with efficacy and safety similar to that of Deferoxamine. Therefore, in patients with Sickle-Cell-Disease, Deferiprone may represent an effective long-term treatment option.

  9. Patterns of recurrence and treatment in male breast cancer: A clue to prognosis?

    Science.gov (United States)

    Henriques Abreu, Miguel; Henriques Abreu, Pedro; Afonso, Noémia; Pereira, Deolinda; Henrique, Rui; Lopes, Carlos

    2016-10-15

    Male breast cancer (MBC) patients seem to have inferior survival compared to female (FBC) ones, which is not fully explained by usual prognostic factors. Recurrence analysis could show differences in relapse patterns and/or in patients' approaches that justify these outcomes. Retrospective analysis of MBC patients treated in a cancer center between 1990 and 2014, looking for relapse. For each patient, three matched FBC patients were selected by: diagnosis' year, age (within 5 years), stage and tumors' type (only luminal-like were considered). Differences between cohorts were assessed by χ(2) test and hierarchical clustering was performed to define subgroups according to relapse local. Survival curves were calculated by Kaplan-Meier and compared using log-rank test. Statistical significance was defined as p male, p = 0.003. Male patients were more often proposed to symptomatic treatment (21.1% vs. 4.4%, p = 0.02). Overall and from recurrence survivals were poorer for male, median: 5 years [95% confidence interval (CI): 4.1-5.9 years] and 1 year (95% CI: 0-2.1 years) vs. 10 years (95% CI: 7.8-12.2 years) and 2 years (95% CI: 1.6-2.4 years), p male could justify the outcomes differences. © 2016 UICC.

  10. Moderately differentiated colorectal adenocarcinoma as a lymph node metastatic phenotype: comparison with well differentiated counterparts

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    Tamura Koichi

    2010-03-01

    Full Text Available Abstract Background The differences between the metastatic property of moderately (Mod and well (Wel differentiated colorectal adenocarcinoma remain unclear. Since Mod is unable to form complete acini, therefore an epithelial-mesenchymal transition (EMT can occur in that structure. Herein, we hypothesized that Mod metastasizes more easily than the Wel counterparts. Methods The medical records of 283 consecutive patients with Mod (n = 71 or Wel (n = 212 who underwent surgery were reviewed between January 1, 2001, and December 31, 2003, for actual 5-year overall survival. We examined the differences between the clinicopathological characteristics of the Mod and the Wel groups. Results The lymph node involvement (p p = 0.0291, Relative Risk of 1.991: 95% Confidence Interval: 1.073-3.697. A Kaplan-Meier survival curve showed that Mod had a trend towards a poor survival (p = 0.0517. Conclusion Mod metastasizes to the lymph nodes more easily in comparison to Wel. Therefore, patients with Mod may be considered the existence of lymph node involvement.

  11. The expression of SIRT1 regulates the metastaticplasticity of chondrosarcoma cells by inducing epithelial-mesenchymal transition

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    Feng, Helin; Wang, Jin; Xu, Jianfa; Xie, Congcong; Gao, Fulu; Li, Zhiyong

    2017-01-01

    SIRT1 belongs to the mammalian sirtuin family and plays an important role in deacetylating histone and nonhistone proteins. It is reported that SIRT1 is associated with tumor metastasis in several kinds of tumors. However, the effect of SIRT1 on the metastasis of chondrosarcoma cells is still unknown. In this study, we demonstrated that up and down-regulation of SIRT1 expression could significantly change the invasive and metastatic potential in chondrosarcoma cell line. Besides that, the result from the nude mice confirmed the effect of SIRT1 on metastasis of chondrosarcoma cells. Furthermore, we also found that SIRT1 effectively enhanced the metastasis by inducing epithelial-mesenchymal transition (EMT) in chondrosarcoma cells. Inhibition the expression of SIRT1 could block the incidence of metastasis and EMT in chondrosarcoma cells. In addition, we also observed that SIRT1 could enhance the expression of Twist which is a key transcriptional factor of EMT. A clinicopathological analysis showed that SIRT1 expression was significantly correlated with the poor prognosis of pelvis chondrosarcoma. Kaplan-Meier survival curves revealed that positive SIRT1 expression was associated with poor prognosis in patients with pelvis chondrosarcoma. Taken together, these results indicate that SIRT1 may promote the metastasis of chondrosarcoma by inducing EMT and can be a potential molecular target for chondrosarcoma therapy. PMID:28112277

  12. CSTP1, a novel protein phosphatase, blocks cell cycle, promotes cell apoptosis, and suppresses tumor growth of bladder cancer by directly dephosphorylating Akt at Ser473 site.

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    De-Xiang Zhuo

    Full Text Available Akt/protein kinase B is a pivotal component downstream of phosphatidylinositol 3-kinase (PI3K pathway, whose activity regulates the balance between cell survival and apoptosis. Phosphorylation of Akt occurs at two key sites either at Thr308 site in the activation loop or at Ser473 site in the hydrophobic motif. The phosphorylated form of Akt (pAkt is activated to promote cell survival. The mechanisms of pAkt dephosphorylation and how the signal transduction of Akt pathway is terminated are still largely unknown. In this study, we identified a novel protein phosphatase CSTP1(complete s transactivated protein 1, which interacts and dephosphorylates Akt specifically at Ser473 site in vivo and in vitro, blocks cell cycle progression and promotes cell apoptosis. The effects of CSTP1 on cell survival and cell cycle were abrogated by depletion of phosphatase domain of CSTP1 or by expression of a constitutively active form of Akt (S473D, suggesting Ser473 site of Akt as a primary cellular target of CSTP1. Expression profile analysis showed that CSTP1 expression is selectively down-regulated in non-invasive bladder cancer tissues and over-expression of CSTP1 suppressed the size of tumors in nude mice. Kaplan-Meier curves revealed that decreased expression of CSTP1 implicated significantly reduced recurrence-free survival in patients suffered from non-invasive bladder cancers.

  13. Ultrasonographic assessment of cervical length in pregnancies scheduled for a cesarean delivery: prediction of early spontaneous onset of labor.

    Science.gov (United States)

    Rizzo, Giuseppe; Aiello, Elisa; Pietrolucci, Maria Elena; Arduini, Domenico

    2016-10-01

    To investigate whether the cervical length measured by transvaginal ultrasound at 35 to 36 weeks of gestation is predictive of spontaneous early onset of labor in pregnancies scheduled for elective cesarean section (CS). This was a prospective observational study on 167 women scheduled for elective CS at 39 weeks of gestation. The cervical length was measured ultrasonographycally at 35 to 36 weeks of gestation and the pregnancies characteristics were recorded. The presence or absence of spontaneous onset of labor before the time scheduled for elective CS was related to cervical length and pregnancies characteristics. Of the 167 pregnancies enrolled, 25 (14.97%) underwent early spontaneous onset of labor before the time scheduled for the elective CS. The cervical length was significantly shorter in these women when compared with those delivering with an elective CS (21 vs. 30 mm z=5.49 Ponset of labor in univariate analysis (P=0.01). Multivariate logistic regression analysis showed that cervical length (adjusted odds ratio 1.40; 95% confidence interval (CI) 1.22-1.61; P≤0.0001) was the only predictor for the early onset of labor. The area under the receiver-operating characteristics curve for the prediction of early onset of labor was 0.844 (95% CI 0.738-0.950) for cervical length as test variable. Kaplan-Meier analysis demonstrated that a cervical length onset of labor in pregnancies scheduled for CS and may be useful in individualizing the gestational age for elective CS.

  14. GNAS1 T393C Polymorphism Is Associated with Clinical Course in Patients with Intrahepatic Cholangiocarcinoma

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    Klaus J. Schmitz

    2007-02-01

    Full Text Available BACKGROUND/AIMS: The GNAS1 locus encodes the Gas protein, which stimulates the formation of cycloadenosinemonophosphate (cAMP. The cAMP pathway mediates pleiotropic effects, including the regulation of apoptosis and proliferation. We have recently shown that TT genotypes of the single-nucleotide polymorphism T393C in the gene GNAS1 predict the clinical outcome of patients with various carcinomas. METHODS: Eighty-seven patients with intrahepatic cholangiocarcinoma (ICC were retrospectively genotyped to elucidate a potential association between T393C genotypes and clinical outcome. RESULTS: ICCs of patients with homozygous TT genotypes revealed a higher proliferation rate and a lower apoptotic rate. Homozygous TT patients were at highest risk for cancer-related deaths (hazard ratio = 2.74; 95% confidence interval = 1.03-7.28 compared with C-allele carriers. Kaplan-Meier curves for disease-specific overall and local recurrence-free survival in a subgroup with Ro-resected ICC showed a significant association of T393 homozygosity with outcome, which was confirmed in multivariate Cox regression analysis. CONCLUSIONS: GNAS1 T393C is a novel independent host factor for disease progression in patients with ICC. Our finding that TT homozygosity (and not CC homozygosity was associated with unfavorable clinical outcome points to the complex and differing functional effects induced by GNAS1 T393C polymorphism in various human carcinomas.

  15. Expression of lactate dehydrogenase C correlates with poor prognosis in renal cell carcinoma.

    Science.gov (United States)

    Hua, Yibo; Liang, Chao; Zhu, Jundong; Miao, Chenkui; Yu, Yajie; Xu, Aimin; Zhang, Jianzhong; Li, Pu; Li, Shuang; Bao, Meiling; Yang, Jie; Qin, Chao; Wang, Zengjun

    2017-03-01

    Lactate dehydrogenase C is an isoenzyme of lactate dehydrogenase and a member of the cancer-testis antigens family. In this study, we aimed to investigate the expression and functional role of lactate dehydrogenase C and its basic mechanisms in renal cell carcinoma. First, a total of 133 cases of renal cell carcinoma samples were analysed in a tissue microarray, and Kaplan-Meier survival curve analyses were performed to investigate the correlation between lactate dehydrogenase C expression and renal cell carcinoma progression. Lactate dehydrogenase C protein levels and messenger RNA levels were significantly upregulated in renal cell carcinoma tissues, and the patients with positive lactate dehydrogenase C expression had a shorter progression-free survival, indicating the oncogenic role of lactate dehydrogenase C in renal cell carcinoma. In addition, further cytological experiments demonstrated that lactate dehydrogenase C could prompt renal cell carcinoma cells to produce lactate, and increase metastatic and invasive potential of renal cell carcinoma cells. Furthermore, lactate dehydrogenase C could induce the epithelial-mesenchymal transition process and matrix metalloproteinase-9 expression. In summary, these findings showed lactate dehydrogenase C was associated with poor prognosis in renal cell carcinoma and played a pivotal role in the migration and invasion of renal cell carcinoma cells. Lactate dehydrogenase C may act as a novel biomarker for renal cell carcinoma progression and a potential therapeutic target for the treatment of renal cell carcinoma.

  16. Retention in Care among HIV-Infected Pregnant Women in Haiti with PMTCT Option B

    Science.gov (United States)

    Massaro, Courtney; Li, Zhongze; Deschamps, Marie-Marcelle; Destine, Cleonas Junior; Senecharles, Redouin; Aristhene, Moleine Moles; Domercant, Joseph Yves; Rouzier, Vanessa; Wright, Peter F.

    2016-01-01

    Background. Preventing mother-to-child transmission of HIV relies on engagement in care during the prenatal, peripartum, and postpartum periods. Under PMTCT Option B, pregnant women with elevated CD4 counts are provided with antiretroviral prophylaxis until cessation of breastfeeding. Methods. Retrospective analysis of retention in care among HIV-infected pregnant women in Haiti was performed. Logistic regression was used to identify risk factors associated with loss to follow-up (LFU) defined as no medical visit for at least 6 months and Kaplan-Meier curves were created to show LFU timing. Results. Women in the cohort had 463 pregnancies between 2009 and 2012 with retention rates of 80% at delivery, 67% at one year, and 59% at 2 years. Among those who were LFU, the highest risk period was during pregnancy (60%) or shortly afterwards (24.4% by 12 months). Never starting on antiretroviral therapy (aRR 2.29, 95% CI 1.4–3.8) was associated with loss to follow-up. Conclusions. Loss to follow-up during and after pregnancy was common in HIV-infected women in Haiti under PMTCT Option B. Since sociodemographic factors and distance from home to facility did not predict LFU, future work should elicit and address barriers to retention at the initial prenatal care visit in all women. Better tracking systems to capture engagement in care in the wider network are needed. PMID:27651953

  17. Colistin-resistant Enterobacteriaceae infections: clinical and molecular characterization and analysis of in vitro synergy.

    Science.gov (United States)

    de Maio Carrillho, Claudia M D; Gaudereto, Juliana J; Martins, Roberta Cristina Ruedas; de Castro Lima, Victor Augusto Camarinha; de Oliveira, Larissa M; Urbano, Mariana R; Perozin, Jamile S; Levin, Anna Sara; Costa, Silvia F

    2017-03-01

    We described 27 polyclonal colistin-resistant Enterobacteriaceae (MIC 4-16 μg/mL) infections (12 pneumonia, 12 urinary tract infection (UTI), two Bacteremia, and one skin/soft tissue infection) in which 74% harbored KPC. The isolates were polyclonal, 6 STs were identified and the colistin resistance was due to chromosome mutations. Eight patients with UTI received monotherapy, and combination therapy was given to 19 patients. Overall mortality was 37%. In vitro synergy using time-kill assay was observed in 14 of 19 (74%) isolates tested; the synergistic effect was observed for almost all isolates for the combination of three drugs: colistin, amikacin, and tigecycline. The Kaplan-Meier survival curve showed no significant difference comparing combination therapy with 2, 3, or more drugs and risk factors associated with death were dialysis and shock. These findings reinforce the fact that colistin in combination with other classes of drugs can be useful in treating infections caused by colistin-resistant CRE.

  18. Clinical Relevance of Telomere Status and Telomerase Activity in Colorectal Cancer.

    Science.gov (United States)

    Fernández-Marcelo, Tamara; Sánchez-Pernaute, Andrés; Pascua, Irene; De Juan, Carmen; Head, Jacqueline; Torres-García, Antonio-José; Iniesta, Pilar

    2016-01-01

    The role of telomeres and telomerase in colorectal cancer (CRC) is well established as the major driving force in generating chromosomal instability. However, their potential as prognostic markers remains unclear. We investigated the outcome implications of telomeres and telomerase in this tumour type. We considered telomere length (TL), ratio of telomere length in cancer to non-cancer tissue (T/N ratio), telomerase activity and TERT levels; their relation with clinical variables and their role as prognostic markers. We analyzed 132 CRCs and paired non-cancer tissues. Kaplan-Meier curves for disease-free survival were calculated for TL, T/N ratio, telomerase activity and TERT levels. Overall, tumours had shorter telomeres than non-tumour tissues (P Telomere lengths of non-tumour tissues and CRCs were positively correlated (P telomere status and clinical variables, the lowest degree of telomere shortening was shown by tumours located in the rectum (P = 0.021). Regarding prognosis studies, patients with tumours showing a mean TL telomere shortening relapsed during the follow-up period (P = 0.043). The mean TL in CRCs emerged as an independent prognostic factor in the Cox analysis (P = 0.017). Telomerase-positive activity was identified as a marker that confers a trend toward a poor prognosis. In CRC, our results support the use of telomere status as an independent prognostic factor. Telomere status may contribute to explaining the different molecular identities of this tumour type.

  19. Different effects of ERβ and TROP2 expression in Chinese patients with early-stage colon cancer.

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    Fang, Yu-Jing; Wang, Guo-Qiang; Lu, Zhen-Hai; Zhang, Lin; Li, Ji-Bin; Wu, Xiao-Jun; Ding, Pei-Rong; Ou, Qing-Jian; Zhang, Mei-Fang; Jiang, Wu; Pan, Zhi-Zhong; Wan, De-Sen

    2012-12-01

    Estrogen receptor beta (ERβ) and TROP2 expressed in colon carcinoma and might play an important role there. We explored the relationship of ERβ and TROP2 expression with the prognosis of early-stage colon cancer. ERβ and TROP2 levels were assessed by immunohistochemistry in normal mucosa and tumoral tissues from 220 Chinese patients with T(3)N(0)M(0) (stage IIa) and T(4)N(0)M(0) (stage IIb) colon cancer in the Cancer Center, Sun Yat-sen University, who underwent curative surgical resection between 1995 and 2003. The Cox proportional hazards regression model was applied to analyze the overall survival (OS) data, and the ROC curve, Kaplan-Meier estimate, log rank test, and Jackknife method were used to show the effect of ERβ and TROP2 expression at different stages of cancer. The 5-year survival rates were not significantly different between the patients with stage IIa and stage IIb colon cancer (83 vs. 80 %, respectively). The high expression of ERβ was related to decreasing OS in stage IIa and stage IIb colon cancer, while the high expression of TROP2 was related to decreasing OS in stage IIb colon cancer. The expression of ERβ and TROP2 has tumor-suppressive and tumor-promoting effect in stage IIa and stage IIb colon cancer, respectively.

  20. [Longitudinal study of the lateness as a predictor of absenteeism: a three-year longitudinal study in a public junior high school in Japan].

    Science.gov (United States)

    Meifu, Yasuko; Iwata, Noboru; Mukasa, Akiko; Tsuda, Akira

    2012-10-01

    Although it is generally believed that frequent lateness might lead to absenteeism, the evidence for this has not been ascertained. We investigated the relationship between earlier lateness and subsequent absenteeism in a three-year longitudinal study in a public junior high school in Japan. The participants were 263 students (124 males, 139 females) whose school records were available for three consecutive academic years. Kaplan-Meier survival curves revealed that students who had been late for 30 or more days during their 1st year of junior high school were significantly more likely to show absenteeism during 2nd and 3rd year than students who had been late less than 30 days. Cox's proportional hazards regression model confirmed that frequent lateness was the only significant predictor, after controlling socio-demographics and psychosocial variables including stressors at school and stress responses. The substantial linkage of frequent lateness to absenteeism found in this study suggests the necessity of paying more attention to lateness for the prevention of absenteeism.

  1. Quantitative computed tomographic descriptors associate tumor shape complexity and intratumor heterogeneity with prognosis in lung adenocarcinoma.

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    Olya Grove

    Full Text Available Two CT features were developed to quantitatively describe lung adenocarcinomas by scoring tumor shape complexity (feature 1: convexity and intratumor density variation (feature 2: entropy ratio in routinely obtained diagnostic CT scans. The developed quantitative features were analyzed in two independent cohorts (cohort 1: n = 61; cohort 2: n = 47 of patients diagnosed with primary lung adenocarcinoma, retrospectively curated to include imaging and clinical data. Preoperative chest CTs were segmented semi-automatically. Segmented tumor regions were further subdivided into core and boundary sub-regions, to quantify intensity variations across the tumor. Reproducibility of the features was evaluated in an independent test-retest dataset of 32 patients. The proposed metrics showed high degree of reproducibility in a repeated experiment (concordance, CCC≥0.897; dynamic range, DR≥0.92. Association with overall survival was evaluated by Cox proportional hazard regression, Kaplan-Meier survival curves, and the log-rank test. Both features were associated with overall survival (convexity: p = 0.008; entropy ratio: p = 0.04 in Cohort 1 but not in Cohort 2 (convexity: p = 0.7; entropy ratio: p = 0.8. In both cohorts, these features were found to be descriptive and demonstrated the link between imaging characteristics and patient survival in lung adenocarcinoma.

  2. Survival analysis of patients with high-grade gliomas based on data mining of imaging variables.

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    Zacharaki, E I; Morita, N; Bhatt, P; O'Rourke, D M; Melhem, E R; Davatzikos, C

    2012-06-01

    The prediction of prognosis in HGGs is poor in the majority of patients. Our aim was to test whether multivariate prediction models constructed by machine-learning methods provide a more accurate predictor of prognosis in HGGs than histopathologic classification. The prediction of survival was based on DTI and rCBV measurements as an adjunct to conventional imaging. The relationship of survival to 55 variables, including clinical parameters (age, sex), categoric or continuous tumor descriptors (eg, tumor location, extent of resection, multifocality, edema), and imaging characteristics in ROIs, was analyzed in a multivariate fashion by using data-mining techniques. A variable selection method was applied to identify the overall most important variables. The analysis was performed on 74 HGGs (18 anaplastic gliomas WHO grades III/IV and 56 GBMs or gliosarcomas WHO grades IV/IV). Five variables were identified as the most significant, including the extent of resection, mass effect, volume of enhancing tumor, maximum B0 intensity, and mean trace intensity in the nonenhancing/edematous region. These variables were used to construct a prediction model based on a J48 classification tree. The average classification accuracy, assessed by cross-validation, was 85.1%. Kaplan-Meier survival curves showed that the constructed prediction model classified malignant gliomas in a manner that better correlates with clinical outcome than standard histopathology. Prediction models based on data-mining algorithms can provide a more accurate predictor of prognosis in malignant gliomas than histopathologic classification alone.

  3. Intraductal papillary mucinous neoplasms of the pancreas: making a disposition using the natural history.

    Science.gov (United States)

    Traverso, L William; Moriya, Toshiyuki; Hashimoto, Yasushi

    2012-04-01

    The process of Intraductal papillary mucinous neoplasms (IPMN) follows the adenoma-to-carcinoma sequence. If it progresses to malignancy about 5 years is required. Even though the process is slow IPMN provides the clinician with the opportunity to avoid malignancy if the patient is at risk. The natural history as observed through Kaplan Meier event curves for occurrence of malignancy show the process to malignancy is much faster (50% within 2 years) if pancreatitis-like symptoms are present or if the main pancreatic duct (MPD) is involved. Almost all decisions to resect (95% in our experience) are based on the presence of symptoms or the MPD location. Cyst size is used infrequently. Every patient with an IPMN should always have a planned follow-up and the frequency depends on the perceived risk of malignancy-immediate imaging if becomes symptomatic to every 2 to 3 years if asymptomatic side branch lesions. The natural history provides modern guidelines for making decisions in patients with a newly discovered IPMN.

  4. THE RELATIONSHIP OF QUARTILE CHARACTERISTIC VALUES BETWEEN DENSITY SURVE AND DISTYIBUTION CURVE

    Institute of Scientific and Technical Information of China (English)

    樊民强; 刘丽俭; 张荣曾

    1998-01-01

    The characteristics of density yield curve of coal and distribution curve of products canbe described with median, quartile deviation, the quartile measure of skewness and kurtosis likeK. On the basis of 16 groups of coal density composition data and their jigging stratification dataderived from the pilot jig, the regression analysis has been done for the relationship between thecharacteristic values of the density curve and the characteristic values of the distribution curve.The results show as follow: (1) The bigger the skewness of the density curve, the bigger theprobable error (Ep) and imperfection (I) are. (2) The bigger the median of density curve, thesmaller the probable error or imperfection is. (3) The characteristic values of density curvehave no influence on the kurtosis K of the distribution curve.

  5. Tokyo Motor Show 2003; Tokyo Motor Show 2003

    Energy Technology Data Exchange (ETDEWEB)

    Joly, E.

    2004-01-01

    The text which follows present the different techniques exposed during the 37. Tokyo Motor Show. The report points out the great tendencies of developments of the Japanese automobile industry. The hybrid electric-powered vehicles or those equipped with fuel cells have been highlighted by the Japanese manufacturers which allow considerable budgets in the research of less polluting vehicles. The exposed models, although being all different according to the manufacturer, use always a hybrid system: fuel cell/battery. The manufacturers have stressed too on the intelligent systems for navigation and safety as well as on the design and comfort. (O.M.)

  6. Quantum spectral curve for (q,t)-matrix model

    CERN Document Server

    Zenkevich, Yegor

    2015-01-01

    We derive quantum spectral curve equation for (q,t)-matrix model, which turns out to be a certain difference equation. We show that in Nekrasov-Shatashvili limit this equation reproduces the Baxter TQ equation for the quantum XXZ spin chain. This chain is spectral dual to the Seiberg-Witten integrable system associated with the AGT dual gauge theory.

  7. The 1.4 GHZ light curve of GRB 970508

    NARCIS (Netherlands)

    Galama, TJ; Wijers, RAMJ; Groot, PJ; Strom, RG; De Bruyn, AG; Kouveliotou, C; Robinson, CR; van Paradus, J

    1998-01-01

    We report on Westerbork 1.4 GHz radio observations of the radio counterpart to gamma-ray burst GRB 970508, between 0.80 and 138 days after this event. The 1.4 GHz light curve shows a transition from optically thick to thin emission between 39 and 54 days after the event. We derive the slope p of the

  8. Getting Tough on Crime: Exercises in Unusual Indifference Curves.

    Science.gov (United States)

    Holahan, William L.

    1998-01-01

    Uses five unusual indifference curve exercises to show how changing the jail sentence and changing the reward for good behavior can influence the crime rate. Recommends eliminating minimum sentencing while raising sentencing and increasing the rewards for good behavior. Includes illustrative graphs for each exercise. (MJP)

  9. Homographic solutions of the curved 3-body problem

    CERN Document Server

    Diacu, Florin

    2010-01-01

    In the 2-dimensional curved 3-body problem, we prove the existence of Lagrangian and Eulerian homographic orbits, and provide their complete classification in the case of equal masses. We also show that the only non-homothetic hyperbolic Eulerian solutions are the hyperbolic Eulerian relative equilibria, a result that proves their instability.

  10. Learning curves in energy planning models

    Energy Technology Data Exchange (ETDEWEB)

    Barreto, L.; Kypreos, S. [Paul Scherrer Inst. (PSI), Villigen (Switzerland)

    1999-08-01

    This study describes the endogenous representation of investment cost learning curves into the MARKAL energy planning model. A piece-wise representation of the learning curves is implemented using Mixed Integer Programming. The approach is briefly described and some results are presented. (author) 3 figs., 5 refs.

  11. Curve Matching with Applications in Medical Imaging

    DEFF Research Database (Denmark)

    Bauer, Martin; Bruveris, Martins; Harms, Philipp

    2015-01-01

    In the recent years, Riemannian shape analysis of curves and surfaces has found several applications in medical image analysis. In this paper we present a numerical discretization of second order Sobolev metrics on the space of regular curves in Euclidean space. This class of metrics has several...

  12. Rotation curve of the Milky Way

    Directory of Open Access Journals (Sweden)

    Lee Y.S.

    2012-02-01

    Full Text Available We use SEGUE and Hipparcos data to restrict the behaviour of the rotation curve of the Milky Way in the solar neighbourhood. Then we construct a density model of the Milky Way which best reproduces the available observations of the rotation curve and is consistent with the density constraints in the solar neighbourhood.

  13. Spectral Curves of Operators with Elliptic Coefficients

    Directory of Open Access Journals (Sweden)

    J. Chris Eilbeck

    2007-03-01

    Full Text Available A computer-algebra aided method is carried out, for determining geometric objects associated to differential operators that satisfy the elliptic ansatz. This results in examples of Lamé curves with double reduction and in the explicit reduction of the theta function of a Halphen curve.

  14. Tautological Integrals on Symmetric Products of Curves

    Institute of Scientific and Technical Information of China (English)

    Zhi Lan WANG

    2016-01-01

    We propose a conjecture on the generating series of Chern numbers of tautological bundles on symmetric products of curves and establish the rank 1 and rank −1 case of this conjecture. Thus we compute explicitly the generating series of integrals of Segre classes of tautological bundles of line bundles on curves, which has a similar structure as Lehn’s conjecture for surfaces.

  15. Green's Conjecture for the generic canonical curve

    OpenAIRE

    Teixidor-I-Bigas, Montserrat

    1998-01-01

    Green's Conjecture states the following : syzygies of the canonical model of a curve are simple up to the p^th stage if and only if the Clifford index of C is greater than p. We prove that the generic curve of genus g satisfies Green's conjecture.

  16. Blending Canal Surfaces Based on PH Curves

    Institute of Scientific and Technical Information of China (English)

    Chen-Dong Xu; Fa-Lai Chen

    2005-01-01

    In this paper, a new method for blending two canal surfaces is proposed. The blending surface is itself a generalized canal surface, the spine curve of which is a PH (Pythagorean-Hodograph) curve. The blending surface possesses an attractive property - its representation is rational. The method is extensible to blend general surfaces as long as the blending boundaries are well-defined.

  17. The density curve of F distribution

    Institute of Scientific and Technical Information of China (English)

    LIU Xiaopeng; LIU Kunhui

    2004-01-01

    Employing the properties of special function,we discuss the positional relation between two density curves with different parameters for F distribution in this paper.Some varying regularities about the position of density curve of F distribution have been obtained.

  18. Electrical-Discharge Machining Of Curved Passages

    Science.gov (United States)

    Guirguis, Kamal S.

    1993-01-01

    Electrical-discharge machining (EDM) used to cut deep hole with bends. EDM process done with articulating segmented electrode. Originally straight, electrode curved as it penetrates part, forming long, smoothly curving hole. After hole cut, honed with slurry to remove thin layer of recast metal created by EDM. Breakage of tools, hand deburring, and drilling debris eliminated.

  19. Integrability and the motion of curves

    Science.gov (United States)

    Nakayama, Kazuaki; Segur, Harvey; Wadati, Miki

    1992-11-01

    Recently discovered connections between integrable evolution equations and the motion of curves are based on the following fact: The Serret-Frenet equations are equivalent to the Ablowitz-Kaup-Newell-Segur (AKNS) scattering problem at zero eigenvalue. This equivalence identifies those evolution equations, integrable or not, that can describe the motion of curves.

  20. Constructing forward price curves in electricity markets

    DEFF Research Database (Denmark)

    Fleten, S.-E.; Lemming, Jørgen Kjærgaard

    2003-01-01

    We present and analyze a method for constructing approximated high-resolution forward price curves in electricity markets. Because a limited number of forward or futures contracts are traded in the market, only a limited picture of the theoretical continuous forward price curve is available...

  1. 47 CFR 80.767 - Propagation curve.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Propagation curve. 80.767 Section 80.767... MARITIME SERVICES Standards for Computing Public Coast Station VHF Coverage § 80.767 Propagation curve. The propagation graph, § 80.767 Graph 1, must be used in computing the service area contour. The graph...

  2. Modeling Start Curves of Bainite Formation

    NARCIS (Netherlands)

    Van Bohemen, S.M.C.

    2009-01-01

    It is demonstrated that calculations with a physically based model give an accurate description of the start curve of bainite formation in a wide range of steels. The temperature dependence of the overall kinetics, which determines the characteristic C shape of the start curve, is controlled by both

  3. CHAOTIC TRANSIENTS IN A CURVED FLUID CONVEYING TUBE

    Institute of Scientific and Technical Information of China (English)

    Ni Qiao; Wang Lin; Qian Qin

    2005-01-01

    The chaotic transients of a curved fluid conveying tube subjected to a nonlinear foundation are investigated. The assumption of the inextensibility of the tube is applied to derive the nonlinear differential equation of motion via the Newtonian approach, with the differential quadrature method used to discretize the curved tube model in the spatial domain. And the nonlinear dynamic motion equation is obtained. The numerical analysis shows that, the final steady states are sensitive to the initial system conditions in a large parameter region of the fluid speed. This phenomenon of chaotic transients is infrequent for fluid conveying tubes.

  4. Preliminary Analysis of ULPC Light Curves Using Fourier Decomposition Technique

    CERN Document Server

    Ngeow, Chow-Choong; Kanbur, Shashi; Barrett, Brittany; Lin, Bin

    2013-01-01

    Recent work on Ultra Long Period Cepheids (ULPCs) has suggested their usefulness as a distance indicator, but has not commented on their relationship as compared with other types of variable stars. In this work, we use Fourier analysis to quantify the structure of ULPC light curves and compare them to Classical Cepheids and Mira variables. Our preliminary results suggest that the low order Fourier parameters of ULPCs show a continuous trend defined by Classical Cepheids after the resonance around 10 days. However their Fourier parameters also overlapped with those from Miras, which make the classification of long period variable stars difficult based on the light curves information alone.

  5. The approach curve method for large anode-cathode distances

    Energy Technology Data Exchange (ETDEWEB)

    Mammana, Victor P.; Monteiro, Othon R.; Fonseca, Leo R.C.

    2003-09-20

    An important technique used to characterize field emission is the measurement of the emitted current against electric field (IxE). In this work we discuss a procedure for obtaining IxE data based on multiple approach curves. We show that the simulated features obtained for an idealized uniform surface matches available experimental data for small anode-cathode distances, while for large distances the simulation predicts a departure from the linear regime. We also discuss the shape of the approach curves for large anode-cathode distances for a cathode made of carbon nanotubes.

  6. The dependence of the abstract boundary classification on a set of curves II: How the classification changes when the bounded parameter property satisfying set of curves changes

    CERN Document Server

    Whale, B E

    2012-01-01

    The abstract boundary uses sets of curves with the bounded parameter property (b.p.p.) to classify the elements of the abstract boundary into regular points, singular points, points at infinity and so on. Building on the material of Part one of this two part series, we show how this classification changes when the set of b.p.p. satisfying curves changes.

  7. Risk Aversion in Game Shows

    DEFF Research Database (Denmark)

    Andersen, Steffen; Lau, Morten I.; Rutström, E. Elisabet

    2008-01-01

    , and the dynamic nature of the task in most games. We consider the game shows Card Sharks, Jeopardy!, Lingo, and finally Deal Or No Deal. We provide a detailed case study of the analyses of Deal Or No Deal, since it is suitable for inference about risk attitudes and has attracted considerable attention....

  8. Phyllodes tumor showing intraductal growth.

    Science.gov (United States)

    Makidono, Akari; Tsunoda, Hiroko; Mori, Miki; Yagata, Hiroshi; Onoda, Yui; Kikuchi, Mari; Nozaki, Taiki; Saida, Yukihisa; Nakamura, Seigo; Suzuki, Koyu

    2013-07-01

    Phyllodes tumor of the breast is a rare fibroepithelial lesion and particularly uncommon in adolescent girls. It is thought to arise from the periductal rather than intralobular stroma. Usually, it is seen as a well-defined mass. Phyllodes tumor showing intraductal growth is extremely rare. Here we report a girl who has a phyllodes tumor with intraductal growth.

  9. Pembrolizumab Shows Promise for NSCLC.

    Science.gov (United States)

    2015-06-01

    Data from the KEYNOTE-001 trial show that pembrolizumab improves clinical outcomes for patients with advanced non-small cell lung cancer, and is well tolerated. PD-L1 expression in at least 50% of tumor cells correlated with improved efficacy.

  10. Create a Polarized Light Show.

    Science.gov (United States)

    Conrad, William H.

    1992-01-01

    Presents a lesson that introduces students to polarized light using a problem-solving approach. After illustrating the concept using a slinky and poster board with a vertical slot, students solve the problem of creating a polarized light show using Polya's problem-solving methods. (MDH)

  11. STATIONARY CONNECTED CURVES IN HILBERT SPACES

    Directory of Open Access Journals (Sweden)

    Raed Hatamleh

    2014-01-01

    Full Text Available In this article the structure of non-stationary curves which are stationary connected in Hilbert space is studied using triangular models of non-self-adjoint operator. The concept of evolutionary representability plays here an important role. It is proved that if one of two curves in Hilbert space is evolutionary representable and the curves are stationary connected, then another curve is evolutionary representable too. These curves are studied firstly. The structure of a cross-correlation function in the case when operator, defining the evolutionary representation, has one-dimensional non-Hermitian subspace (the spectrum is discreet and situated in the upper complex half-plane or has infinite multiplicity at zero (Volterra operator is studied.

  12. Curved and conformal high-pressure vessel

    Energy Technology Data Exchange (ETDEWEB)

    Croteau, Paul F.; Kuczek, Andrzej E.; Zhao, Wenping

    2016-10-25

    A high-pressure vessel is provided. The high-pressure vessel may comprise a first chamber defined at least partially by a first wall, and a second chamber defined at least partially by the first wall. The first chamber and the second chamber may form a curved contour of the high-pressure vessel. A modular tank assembly is also provided, and may comprise a first mid tube having a convex geometry. The first mid tube may be defined by a first inner wall, a curved wall extending from the first inner wall, and a second inner wall extending from the curved wall. The first inner wall may be disposed at an angle relative to the second inner wall. The first mid tube may further be defined by a short curved wall opposite the curved wall and extending from the second inner wall to the first inner wall.

  13. Review: J-integral resistance curve testing and evaluation

    Institute of Scientific and Technical Information of China (English)

    Xian-kui ZHU

    2009-01-01

    In this paper a critical review is presented of the history and current state of the art of J-integral resistance curve testing and experimental evaluation methods in conjunction with a discussion of the development of the plane strain fracture toughness test standard ASTM E 1820 developed by American Society for Testing and Materials (ASTM). Early research efforts on this topic are reviewed first. These include the J-integral concept, experimental estimates of the J-integral for stationary cracks, load line displacement (LLD) and crack mouth opening displacement (CMOD) based η factor equations, different formulations of J-integral incremental equations for growing cracks, crack growth corrected J-R curve determination, and experimental test methods. Recent developments in J-R curve testing and evaluation are then described, with emphasis on accurate J-integral incremental equations,a normalization method, a modified basic method, a CMOD direct method with use of incremental equations, relationships of plastic geometry factors, constraint-dependent J-R curve testing and correction approaches. An overview of the present fracture toughness test standard ASTM E1820-08a is then presented. The review shows that after more than 40 years of investigation and development, the J-integral resistance curve test methods in ASTM E 1820 have become simpler, more cost-effective and more accurate.

  14. Seismic Fragility Curves of Industrial Buildings by Using Nonlinear Analysis

    Directory of Open Access Journals (Sweden)

    Mohamed Nazri Fadzli

    2017-01-01

    Full Text Available This study presents the steel fragility curves and performance curves of industrial buildings of different geometries. The fragility curves were obtained for different building geometries, and the performance curves were developed based on lateral load, which is affected by the geometry of the building. Three records of far-field ground motion were used for incremental dynamic analysis (IDA, and the design lateral loads for pushover analysis (POA. All designs were based on British Standard (BS 5950; however, Eurocode 8 was preferred for seismic consideration in the analysis because BS 5950 does not specify any seismic provision. The five levels of performance stated by FEMA-273, namely, operational phase, immediate occupancy, damage control, life safety, and collapse prevention (CP were used as main guidelines for evaluating structural performance. For POA, Model 2 had highest base shear, followed by Model 1 and Model 3, even though Model 2 has a smaller structure compared with Model 3. Meanwhile, the fragility curves showed that the probability of reaching or exceeding the CP level of Model 2 is the highest, followed by that of Models 1 and 3.

  15. Characterizing time series via complexity-entropy curves

    Science.gov (United States)

    Ribeiro, Haroldo V.; Jauregui, Max; Zunino, Luciano; Lenzi, Ervin K.

    2017-06-01

    The search for patterns in time series is a very common task when dealing with complex systems. This is usually accomplished by employing a complexity measure such as entropies and fractal dimensions. However, such measures usually only capture a single aspect of the system dynamics. Here, we propose a family of complexity measures for time series based on a generalization of the complexity-entropy causality plane. By replacing the Shannon entropy by a monoparametric entropy (Tsallis q entropy) and after considering the proper generalization of the statistical complexity (q complexity), we build up a parametric curve (the q -complexity-entropy curve) that is used for characterizing and classifying time series. Based on simple exact results and numerical simulations of stochastic processes, we show that these curves can distinguish among different long-range, short-range, and oscillating correlated behaviors. Also, we verify that simulated chaotic and stochastic time series can be distinguished based on whether these curves are open or closed. We further test this technique in experimental scenarios related to chaotic laser intensity, stock price, sunspot, and geomagnetic dynamics, confirming its usefulness. Finally, we prove that these curves enhance the automatic classification of time series with long-range correlations and interbeat intervals of healthy subjects and patients with heart disease.

  16. AHT Bézier Curves and NUAHT B-Spline Curves

    Institute of Scientific and Technical Information of China (English)

    Gang Xu; Guo-Zhao Wang

    2007-01-01

    In this paper, we present two new unified mathematics models of conics and polynomial curves, called algebraic hyperbolic trigonometric ( AHT) Bézier curves and non-uniform algebraic hyperbolic trigonometric ( NUAHT) B-sptine curves of order n, which are generated over the space span{sin t, cos t, sinh t, cosh t, 1, t,..., tn-5}, n ≥ 5. The two kinds of curves share most of the properties as those of the Bézier curves and B-spline curves in polynomial space. In particular, they can represent exactly some remarkable transcendental curves such as the helix, the cycloid and the catenary. The subdivision formulae of these new kinds of curves are also given. The generations of the tensor product surfaces are straightforward. Using the new mathematics models, we present the control mesh representations of two classes of minimal surfaces.

  17. Indifference curves as a tool for environment impact assessment.

    Science.gov (United States)

    Srivastava, Anjali; Ganguly, Arpita

    2010-01-01

    Use of indifference curves, defined as functionality between development index and pollution load to evaluate environmental impact, is proposed. Existing Battelle environmental evaluation methodology is subjective in its approach. The use of indifference curves lends a more objective approach to environment assessment methodology. The extent of environmental damage we are prepared to accept, for a development, can be explained by Willingness to Pay and Willingness to Accept approach. The application of proposed approach has been demonstrated taking an example of Power plant set up in forest area. The curves clearly show that cost of EMP considering mitigation of ecological damage is higher than the EMP mitigating impacts of air and water pollution only. The example stresses the need for willingness to accept along with willingness to pay.

  18. Computing Numerical Singular Points of Plane Algebraic Curves

    Institute of Scientific and Technical Information of China (English)

    LUO ZHONG-XUAN; FENG ER-BAO; HU WEN-YU

    2012-01-01

    Given an irreducible plane algebraic curve of degree d ≥ 3,we compute its numerical singular points,determine their multiplicities,and count the number of distinct tangents at each to decide whether the singular points are ordinary.The numerical procedures rely on computing numerical solutions of polynomial systems by homotopy continuation method and a reliable method that calculates multiple roots of the univariate polynomials accurately using standard machine precision.It is completely different from the traditional symbolic computation and provides singular points and their related properties of some plane algebraic curves that the symbolic software Maple cannot work out.Without using multiprecision arithmetic,extensive numerical experiments show that our numerical procedures are accurate,efficient and robust,even if the coefficients of plane algebraic curves are inexact.

  19. Shaping the learning curve: epigenetic dynamics in neural plasticity

    Directory of Open Access Journals (Sweden)

    Zohar Ziv Bronfman

    2014-07-01

    Full Text Available A key characteristic of learning and neural plasticity is state-dependent acquisition dynamics reflected by the non-linear learning curve that links increase in learning with practice. Here we propose that the manner by which epigenetic states of individual cells change during learning contributes to the shape of the neural and behavioral learning curve. We base our suggestion on recent studies showing that epigenetic mechanisms such as DNA methylation, histone acetylation and RNA-mediated gene regulation are intimately involved in the establishment and maintenance of long-term neural plasticity, reflecting specific learning-histories and influencing future learning. Our model, which is the first to suggest a dynamic molecular account of the shape of the learning curve, leads to several testable predictions regarding the link between epigenetic dynamics at the promoter, gene-network and neural-network levels. This perspective opens up new avenues for therapeutic interventions in neurological pathologies.

  20. Jacobian Groups of Hyperelliptic Curves in Hyperelliptic Cryptosystems

    Institute of Scientific and Technical Information of China (English)

    YOULin; FANYun

    2003-01-01

    After the basic mathematical knowledge about hyperelliptic curves is introduced, we analyze the Jacobian groups of hyperelliptic curves and the computations of divisor additions. By using Riemann-Roch Theorem we give a short proof that any divisor of degree 0 is uniquely equivalent to a reduced divisor. For the hyperelliptic curve v2+h(u)v=f(u), We show that every polynomial pair (a(u), b(u)) satisfying a(u)|(b(u)2 + b(u)h(u) - f(u))determines a unique reduced divisor div(a(u), b(u)). In addition, we point out that additions in Jacobian groups can be performed in two ways.

  1. Method for estimating spin-spin interactions from magnetization curves

    Science.gov (United States)

    Tamura, Ryo; Hukushima, Koji

    2017-02-01

    We develop a method to estimate the spin-spin interactions in the Hamiltonian from the observed magnetization curve by machine learning based on Bayesian inference. In our method, plausible spin-spin interactions are determined by maximizing the posterior distribution, which is the conditional probability of the spin-spin interactions in the Hamiltonian for a given magnetization curve with observation noise. The conditional probability is obtained with the Markov chain Monte Carlo simulations combined with an exchange Monte Carlo method. The efficiency of our method is tested using synthetic magnetization curve data, and the results show that spin-spin interactions are estimated with a high accuracy. In particular, the relevant terms of the spin-spin interactions are successfully selected from the redundant interaction candidates by the l1 regularization in the prior distribution.

  2. Effects of spacetime anisotropy on the galaxy rotation curves

    CERN Document Server

    Chang, Zhe; Li, Xin; Lin, Hai-Nan; Wang, Sai

    2013-01-01

    The observations on galaxy rotation curves show significant discrepancies from the Newtonian theory. This issue could be explained by the effect of the anisotropy of the spacetime. Conversely, the spacetime anisotropy could also be constrained by the galaxy rotation curves. Finsler geometry is a kind of intrinsically anisotropic geometry. In this paper, we study the effect of the spacetime anisotropy at the galactic scales in the Finsler spacetime. It is found that the Finslerian model has close relations with the Milgrom's MOND. By performing the best-fit procedure to the galaxy rotation curves, we find that the anisotropic effects of the spacetime become significant when the Newtonian acceleration \\(GM/r^2\\) is smaller than the critical acceleration \\(a_0\\). Interestingly, the critical acceleration \\(a_0\\), although varies between different galaxies, is in the order of magnitude \\(cH_0/2\\pi\\sim 10^{-10} \\rm{m\\,\\, s^{-2}}\\).

  3. Decision curve analysis revisited: overall net benefit, relationships to ROC curve analysis, and application to case-control studies

    Directory of Open Access Journals (Sweden)

    Zumbrunn Thomas

    2011-06-01

    Full Text Available Abstract Background Decision curve analysis has been introduced as a method to evaluate prediction models in terms of their clinical consequences if used for a binary classification of subjects into a group who should and into a group who should not be treated. The key concept for this type of evaluation is the "net benefit", a concept borrowed from utility theory. Methods We recall the foundations of decision curve analysis and discuss some new aspects. First, we stress the formal distinction between the net benefit for the treated and for the untreated and define the concept of the "overall net benefit". Next, we revisit the important distinction between the concept of accuracy, as typically assessed using the Youden index and a receiver operating characteristic (ROC analysis, and the concept of utility of a prediction model, as assessed using decision curve analysis. Finally, we provide an explicit implementation of decision curve analysis to be applied in the context of case-control studies. Results We show that the overall net benefit, which combines the net benefit for the treated and the untreated, is a natural alternative to the benefit achieved by a model, being invariant with respect to the coding of the outcome, and conveying a more comprehensive picture of the situation. Further, within the framework of decision curve analysis, we illustrate the important difference between the accuracy and the utility of a model, demonstrating how poor an accurate model may be in terms of its net benefit. Eventually, we expose that the application of decision curve analysis to case-control studies, where an accurate estimate of the true prevalence of a disease cannot be obtained from the data, is achieved with a few modifications to the original calculation procedure. Conclusions We present several interrelated extensions to decision curve analysis that will both facilitate its interpretation and broaden its potential area of application.

  4. Unifying representation of Bézier curve and two kinds of generalized ball curves

    Institute of Scientific and Technical Information of China (English)

    ZHU Xiaolin; WANG Zhihua

    2012-01-01

    This paper presents a new basis, the WSB basis, which unifies the Bemstein basis, Wang-Ball basis and Said-Ball basis, and therefore the Bézier curve, Wang-Ball curve and Said-Ball curve are the special cases of the WSB curve based on the WSB basis In addition, the relative degree elevation formula, recursive algorithm and conversion formula between the WSB basis and the Bern- stein basis are given.

  5. Reality show: um paradoxo nietzschiano

    Directory of Open Access Journals (Sweden)

    Ilana Feldman

    2011-01-01

    Full Text Available

    O fenômeno dos reality shows - e a subseqüente relação entre imagem e verdade - assenta-se sobre uma série de paradoxos. Tais paradoxos podem ser compreendidos à luz do pensamento do filósofo alemão Friedrich Nietzsche, que, através dos usos de formulações paradoxais, concebia a realidade como um mundo de pura aparência e a verdade como um acréscimo ficcional, como um efeito. A ficção é então tomada, na filosofia de Nietzsche, não em seu aspecto falsificante e desrealizador - como sempre pleiteou nossa tradição metafísica -, mas como condição necessária para que certa espécie de invenção possa operar como verdade. Sendo assim, a própria expressão reality show, através de sua formulação paradoxal, engendra explicitamente um mundo de pura aparência, em que a verdade, a parte reality da proposição, é da ordem do suplemento, daquilo que se acrescenta ficcionalmente - como um adjetivo - a show. O ornamento, nesse caso, passa a ocupar o lugar central, apontando para o efeito produzido: o efeito-de-verdade. Seguindo, então, o pensamento nietzschiano e sua atualização na contemporaneidade, investigaremos de que forma os televisivos “shows de realidade” operam paradoxalmente, em consonância com nossas paradoxais práticas culturais.

  6. Folding of non-Euclidean curved shells

    Science.gov (United States)

    Bende, Nakul; Evans, Arthur; Innes-Gold, Sarah; Marin, Luis; Cohen, Itai; Santangelo, Christian; Hayward, Ryan

    2015-03-01

    Origami-based folding of 2D sheets has been of recent interest for a variety of applications ranging from deployable structures to self-folding robots. Though folding of planar sheets follows well-established principles, folding of curved shells involves an added level of complexity due to the inherent influence of curvature on mechanics. In this study, we use principles from differential geometry and thin shell mechanics to establish fundamental rules that govern folding of prototypical creased shells. In particular, we show how the normal curvature of a crease line controls whether the deformation is smooth or discontinuous, and investigate the influence of shell thickness and boundary conditions. We show that snap-folding of shells provides a route to rapid actuation on time-scales dictated by the speed of sound. The simple geometric design principles developed can be applied at any length-scale, offering potential for bio-inspired soft actuators for tunable optics, microfluidics, and robotics. This work was funded by the National Science Foundation through EFRI ODISSEI-1240441 with additional support to S.I.-G. through the UMass MRSEC DMR-0820506 REU program.

  7. Investigating the energy-environmental Kuznets curve

    Energy Technology Data Exchange (ETDEWEB)

    Luzzati, T.; Orsini, M. [Dipartimento di Scienze Economiche, Facolta di Economia, Universita di Pisa. Via Ridolfi 10, I-56124 PISA (Italy)

    2009-03-15

    This paper investigates the relationship between absolute energy consumption and gross domestic product (GDP) per capita for 113 countries over the period 1971-2004. Energy has been scarcely explored in the Environmental Kuznets curve (EKC) debate and is taken as the indicator of overall environmental pressure. The following aspects of this work are rather innovative. Firstly, in order to closely adhere to the EKC narratives, the indicator of environmental pressure (energy) is taken in absolute terms rather than per capita. Secondly, we look for consistency both between different econometric techniques (parametric and semi-parametric) and across different analytical levels (world, time series/cross-countries, and single countries). Finally, the dataset is large and not limited to developed countries. In our opinion, the estimates cannot support an energy-EKC hypothesis. For the world as a single unit, the relationship is positive monotone, with a lower (though still positive) elasticity after 1989. A glance at single country level does not reveal evidence of EKC. Cross-country analysis is slightly more open to interpretation; in any case, however, it shows that the potential benefits of GDP growth on natural environment, if any, did not show up in the considered time span. (author)

  8. Adiabatic paths and pseudoholomorphic curves

    Institute of Scientific and Technical Information of China (English)

    Armen; G.; Sergeev

    2005-01-01

    We consider the (2+1)-dimensional Abelian Higgs model, governed by the Ginzburg-Landau action functional and describe the adiabatic limit construction for this model. Then we switch to the 4-dimensional case and Show that the Taubes correspondence may be considered as a (2+2)-dimensional analogue of the adiabatic limit construction.

  9. Picasso on Show in Shanghai

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    A staff member of the National Picasso Museum of France checks one of the great Spanish artist Pablo Picasso’s works at the China Pavilion inside the site of the 2010 World Expo in Shanghai on October 12.Sixty-two priceless paintings and statues selected from the works of the renowned artist have been brought to the pavilion for an upcoming exhibition to premiere on October 18.Besides these representative masterpieces,50 valuable photographs showing the artist’s whole life will also be presented.The exhibition’s estimated value is 678 million euros ($934 million).It will be held until January 10,2012.

  10. Interval Polynomial Curves Approximation of Offset Curves%Offset曲线的区间多项式逼近

    Institute of Scientific and Technical Information of China (English)

    陈效群; 冯玉瑜; 娄文平

    2003-01-01

    用一个较简单的逼近格式去逼近Bézier曲线的offset曲线,即用一个三次参数曲线去逼近offset曲线.通过分析逼近误差而由此给出了offset曲线的区间多项式逼近,即得到了一个包含offset曲线的区间Bézier曲线.同时给出了区间Bézier曲线的区间控制点的大小与Bezer曲线控制顶点之间的关系.最后举出实例说明这种逼近方法可以与细分技术结合达到很好的逼近效果.%This paper is devoted to the study of an approximation algorithm of offset curves for the parametric Bézier curves. By considering the error of approximation, we give an interval polynomial approximation of the offset curve and obtain an interval Bézier curve only containing one interval point, the others are degenerate ones. We also develop a relation among the interval control points of the interval Bézier curve. Some examples show that such approximation coupled with the subdivision leads to better approximation effects.

  11. Reality shows: uma abordagem psicossocial

    Directory of Open Access Journals (Sweden)

    Marília Pereira Bueno Millan

    Full Text Available Desde os primórdios da civilização, o ser humano mostra necessidade de representar cenicamente seus dramas pessoais e vicissitudes existenciais. O "reality show" é uma das versões pós-modernas da encenação da vida humana. Este artigo, por meio de uma pesquisa bibliográfica, analisa criticamente as relações existentes entre o "reality show" e aspectos psicossociais do comportamento humano. Conclui-se que tais programas televisivos são o retrato da contemporaneidade, ou seja, revelam a morte do sujeito, a fugacidade das experiências vividas, a desvalorização da história e o culto à imagem e à superficialidade. Por meio da sedução do espectador, mobilizam-se aspectos primitivos de seu psiquismo, fazendo com que ele se sinta narcisicamente poderoso e onipotente e se acredite dono do destino dos participantes do programa. Sugerem-se novos estudos que contribuam para a reflexão crítica e maior conscientização.

  12. "Medicine show." Alice in Doctorland.

    Science.gov (United States)

    1987-01-01

    This is an excerpt from the script of a 1939 play provided to the Institute of Social Medicine and Community Health by the Library of Congress Federal Theater Project Collection at George Mason University Library, Fairfax, Virginia, pages 2-1-8 thru 2-1-14. The Federal Theatre Project (FTP) was part of the New Deal program for the arts 1935-1939. Funded by the Works Progress Administration (WPA) its goal was to employ theater professionals from the relief rolls. A number of FTP plays deal with aspects of medicine and public health. Pageants, puppet shows and documentary plays celebrated progress in medical science while examining social controversies in medical services and the public health movement. "Medicine Show" sharply contrasts technological wonders with social backwardness. The play was rehearsed by the FTP but never opened because funding ended. A revised version ran on Broadway in 1940. The preceding comments are adapted from an excellent, well-illustrated review of five of these plays by Barabara Melosh: "The New Deal's Federal Theatre Project," Medical Heritage, Vol. 2, No. 1 (Jan/Feb 1986), pp. 36-47.

  13. Investigation of learning and experience curves

    Energy Technology Data Exchange (ETDEWEB)

    Krawiec, F.; Thornton, J.; Edesess, M.

    1980-04-01

    The applicability of learning and experience curves for predicting future costs of solar technologies is assessed, and the major test case is the production economics of heliostats. Alternative methods for estimating cost reductions in systems manufacture are discussed, and procedures for using learning and experience curves to predict costs are outlined. Because adequate production data often do not exist, production histories of analogous products/processes are analyzed and learning and aggregated cost curves for these surrogates estimated. If the surrogate learning curves apply, they can be used to estimate solar technology costs. The steps involved in generating these cost estimates are given. Second-generation glass-steel and inflated-bubble heliostat design concepts, developed by MDAC and GE, respectively, are described; a costing scenario for 25,000 units/yr is detailed; surrogates for cost analysis are chosen; learning and aggregate cost curves are estimated; and aggregate cost curves for the GE and MDAC designs are estimated. However, an approach that combines a neoclassical production function with a learning-by-doing hypothesis is needed to yield a cost relation compatible with the historical learning curve and the traditional cost function of economic theory.

  14. Cosmology and galactic rotation curves

    CERN Document Server

    Mannheim, P D

    1995-01-01

    We explore the possibility that the entire departure of galactic rotational velocities from their luminous Newtonian expectation be cosmological in origin, and show that within the framework of conformal gravity (but not Einstein gravity apparently) every static observer sees the overall Hubble flow as a local universal linear potential which is able to account for available data without any need for dark matter. We find that the Universe is necessarily an open one with 3-space scalar curvature given by k = -3.5\\times 10^{-60}cm^{-2}.

  15. Supersonic Flutter of Laminated Curved Panels

    Directory of Open Access Journals (Sweden)

    M. Ganapathi

    1995-04-01

    Full Text Available Supersonic flutter analysis of laminated composite curved panels is investigated using doubly-curved, quadrilateral, shear flexible, shell element based on field-consistency approach. The formulation includes transverse shear deformation, in-plane and rotary inertias. The aerodynamic force is evaluated using two-dimensional static aerodynamic approximation for high supersonic flow. Initially, the model developed here is verified for the flutter analysis of flat plates. Numerical results are presented for isotropic, orthotropic and laminated anisotropic curved panels. A detailed parametric study is carried out to observe the effects of aspect and thickness ratios, number of layers, lamination scheme, and boundary conditions on flutter boundary.

  16. Magnetization curve modelling of soft magnetic alloys

    Energy Technology Data Exchange (ETDEWEB)

    Meszaros, I, E-mail: meszaros@eik.bme.hu [Department of Materials Science and Engineering, Budapest University of Technology and Economics, Bertalan L. street 7., Budapest, H-1111 (Hungary)

    2011-01-01

    In this paper we present an application of the so called hyperbolic model of magnetization. The model was modified and it was applied for nine different soft magnetic alloys. The tested samples were electro-technical steels (FeSi alloys) and a permalloy (FeNi alloy) with strongly different magnetic properties. Among them there are top, medium and definitely poor quality soft magnetic materials as well. Their minor hysteresis loops and normal magnetization curves were measured by alternating current measurement. The hyperbolic model of magnetization was applied for the experimental normal magnetization curves. It was proved that the applied model is excellent for describing mathematically the experimental magnetization curves.

  17. CRC standard curves and surfaces with Mathematica

    CERN Document Server

    von Seggern, David H

    2006-01-01

    Since the publication of the first edition, Mathematica® has matured considerably and the computing power of desktop computers has increased greatly. This enables the presentation of more complex curves and surfaces as well as the efficient computation of formerly prohibitive graphical plots. Incorporating both of these aspects, CRC Standard Curves and Surfaces with Mathematica®, Second Edition is a virtual encyclopedia of curves and functions that depicts nearly all of the standard mathematical functions rendered using Mathematica. While the easy-to-use format remains unchanged from the previ

  18. Curves and surfaces in the context of optometry. Part 1: Curves*

    OpenAIRE

    2005-01-01

    This paper introduces the differential geom-etry of curves in Euclidean 3-space, the motiva-tion being the writer’s belief that, despite their fundamental importance, curves are inadequate-ly treated in optometric educational programs. Curvature and torsion are defined along a curve. Two  numerical  examples  are  presented.  The fundamental theorem of curves is stated. The relationship of the geometry of varifocal lenses and curves known as involutes are discussed. A brief treatment of the t...

  19. Effect of the interaction among traps on the shape of thermoluminescence glow curves

    Energy Technology Data Exchange (ETDEWEB)

    Marcazzo, J. [IFAS, Facultad de Ciencias Exactas, Universidad Nacional del Centro de la Provincia de Buenos Aires, Pinto 399, 7000 Tandil (Argentina); Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET), Rivadavia 1917, 1033 Buenos Aires (Argentina); Santiago, M. [IFAS, Facultad de Ciencias Exactas, Universidad Nacional del Centro de la Provincia de Buenos Aires, Pinto 399, 7000 Tandil (Argentina) and Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET), Rivadavia 1917, 1033 Buenos Aires (Argentina)]. E-mail: msantiag@exa.unicen.edu.ar; Spano, F. [Autoridad Regulatoria Nuclear, Av. del Libertador 8250, 1429 Buenos Aires (Argentina); Lester, M. [IFAS, Facultad de Ciencias Exactas, Universidad Nacional del Centro de la Provincia de Buenos Aires, Pinto 399, 7000 Tandil (Argentina); Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET), Rivadavia 1917, 1033 Buenos Aires (Argentina); Ortega, F. [Facultad de Ingenieria, Universidad Nacional del Centro de la Provincia de Buenos Aires, Av. del Valle 5737, 7400 Olavarria (Argentina); Molina, P. [IFAS, Facultad de Ciencias Exactas, Universidad Nacional del Centro de la Provincia de Buenos Aires, Pinto 399, 7000 Tandil (Argentina); Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET), Rivadavia 1917, 1033 Buenos Aires (Argentina); Caselli, E. [IFAS, Facultad de Ciencias Exactas, Universidad Nacional del Centro de la Provincia de Buenos Aires, Pinto 399, 7000 Tandil (Argentina); Comision de Investigaciones Cientificas de la Provincia de Buenos Aires (CICPBA), calle 526 entre 10 y 11, 1900 La Plata (Argentina)

    2007-09-15

    The effect of the interaction among traps on the structure of thermoluminescence glow curves has been investigated by generating numerically simulated glow curves for a wide range of trap parameters. The results reported in this paper provide useful insights which assist in the analysis of experimental glow curves. The most important result shows that it is incorrect to assume beforehand that each peak is related to a specific trapping state. The validity of the quasiequilibrium approximation is briefly discussed.

  20. Casimir experiments showing saturation effects

    CERN Document Server

    Sernelius, Bo E

    2009-01-01

    We address several different Casimir experiments where theory and experiment disagree. First out is the classical Casimir force measurement between two metal half spaces; here both in the form of the torsion pendulum experiment by Lamoreaux and in the form of the Casimir pressure measurement between a gold sphere and a gold plate as performed by Decca et al.; theory predicts a large negative thermal correction, absent in the high precision experiments. The third experiment is the measurement of the Casimir force between a metal plate and a laser irradiated semiconductor membrane as performed by Chen et al.; the change in force with laser intensity is larger than predicted by theory. The fourth experiment is the measurement of the Casimir force between an atom and a wall in the form of the measurement by Obrecht et al. of the change in oscillation frequency of a 87 Rb Bose-Einstein condensate trapped to a fused silica wall; the change is smaller than predicted by theory. We show that saturation effects can exp...

  1. Functional dynamic factor models with application to yield curve forecasting

    KAUST Repository

    Hays, Spencer

    2012-09-01

    Accurate forecasting of zero coupon bond yields for a continuum of maturities is paramount to bond portfolio management and derivative security pricing. Yet a universal model for yield curve forecasting has been elusive, and prior attempts often resulted in a trade-off between goodness of fit and consistency with economic theory. To address this, herein we propose a novel formulation which connects the dynamic factor model (DFM) framework with concepts from functional data analysis: a DFM with functional factor loading curves. This results in a model capable of forecasting functional time series. Further, in the yield curve context we show that the model retains economic interpretation. Model estimation is achieved through an expectation- maximization algorithm, where the time series parameters and factor loading curves are simultaneously estimated in a single step. Efficient computing is implemented and a data-driven smoothing parameter is nicely incorporated. We show that our model performs very well on forecasting actual yield data compared with existing approaches, especially in regard to profit-based assessment for an innovative trading exercise. We further illustrate the viability of our model to applications outside of yield forecasting.

  2. Supersymmetry on curved spaces and superconformal anomalies

    CERN Document Server

    Cassani, Davide

    2013-01-01

    We study the consequences of unbroken rigid supersymmetry of four-dimensional field theories placed on curved manifolds. We show that in Lorentzian signature the background vector field coupling to the R-current is determined by the Weyl tensor of the background metric. In Euclidean signature, the same holds if two supercharges of opposite R-charge are preserved, otherwise the (anti-)self-dual part of the vector field-strength is fixed by the Weyl tensor. As a result of this relation, the trace and R-current anomalies of superconformal field theories simplify, with the trace anomaly becoming purely topological. In particular, in Lorentzian signature, or in the presence of two Euclidean supercharges of opposite R-charge, supersymmetry of the background implies that the term proportional to the central charge c vanishes, both in the trace and R-current anomalies. This is equivalent to the vanishing of a superspace Weyl invariant. We comment on the implications of our results for holography.

  3. Roots of Dehn twists about separating curves

    CERN Document Server

    Rajeevsarathy, Kashyap

    2011-01-01

    Let $C$ be a curve in a closed orientable surface $F$ of genus $g \\geq 2$ that separates $F$ into subsurfaces $\\widetilde {F_i}$ of genera $g_i$, for $i = 1,2$. We study the set of roots in $\\Mod(F)$ of the Dehn twist $t_C$ about $C$. All roots arise from pairs of $C_{n_i}$-actions on the $\\widetilde{F_i}$, where $n=\\lcm(n_1,n_2)$ is the degree of the root, that satisfy a certain compatibility condition. The $C_{n_i}$ actions are of a kind that we call nestled actions, and we classify them using tuples that we call data sets. The compatibility condition can be expressed by a simple formula, allowing a classification of all roots of $t_C$ by compatible pairs of data sets. We use these data set pairs to classify all roots for $g = 2$ and $g = 3$. We show that there is always a root of degree at least $2g^2+2g$, while $n \\leq 4g^2+2g$. We also give some additional applications.

  4. Stiefel-Whitney classes of curve covers

    Science.gov (United States)

    Selander, Björn

    2016-10-01

    Let D be a Dedekind scheme with the characteristic of all residue fields not equal to 2. To every tame cover Cto D with only odd ramification we associate a second Stiefel-Whitney class in the second cohomology with mod 2 coefficients of a certain tame orbicurve [D] associated to D. This class is then related to the pull-back of the second Stiefel-Whitney class of the push-forward of the line bundle of half of the ramification divisor. This shows (indirectly) that our Stiefel-Whitney class is the pull-back of a sum of cohomology classes considered by Esnault, Kahn and Viehweg in `Coverings with odd ramification and Stiefel-Whitney classes'. Perhaps more importantly, in the case of a proper and smooth curve over an algebraically closed field, our Stiefel-Whitney class is shown to be the pull-back of an invariant considered by Serre in `Revêtements à ramification impaire et thêta-caractéristiques', and in this case our arguments give a new proof of the main result of that article.

  5. Environmental Kuznets Curve Hypothesis. A Survey

    Energy Technology Data Exchange (ETDEWEB)

    Dinda, Soumyananda [Economic Research Unit, Indian Statistical Institute, 203, B.T. Road, Kolkata-108 (India)

    2004-08-01

    The Environmental Kuznets Curve (EKC) hypothesis postulates an inverted-U-shaped relationship between different pollutants and per capita income, i.e., environmental pressure increases up to a certain level as income goes up; after that, it decreases. An EKC actually reveals how a technically specified measurement of environmental quality changes as the fortunes of a country change. A sizeable literature on EKC has grown in recent period. The common point of all the studies is the assertion that the environmental quality deteriorates at the early stages of economic development/growth and subsequently improves at the later stages. In other words, environmental pressure increases faster than income at early stages of development and slows down relative to GDP growth at higher income levels. This paper reviews some theoretical developments and empirical studies dealing with EKC phenomenon. Possible explanations for this EKC are seen in (1) the progress of economic development, from clean agrarian economy to polluting industrial economy to clean service economy; (2) tendency of people with higher income having higher preference for environmental quality, etc. Evidence of the existence of the EKC has been questioned from several corners. Only some air quality indicators, especially local pollutants, show the evidence of an EKC. However, an EKC is empirically observed, till there is no agreement in the literature on the income level at which environmental degradation starts declining. This paper provides an overview of the EKC literature, background history, conceptual insights, policy and the conceptual and methodological critique.

  6. Water Retention Curves of Opalinus Clay

    Energy Technology Data Exchange (ETDEWEB)

    Villar, M. V.; Romero, F. J.

    2012-11-01

    The water retention curve of Opalinus clay samples was determined under different conditions: total and matric suction, stress or no-stress conditions, wetting and drying paths. Through the fitting of these results to the van Genuchten expression the P parameter, related to the air entry value (AEV), was obtained. The AEV is the suction value above which air is able to enter the pores of the sample, and consequently, above which 2-phase flow can take place in the soil pore structure. The samples used in this research came from two different boreholes, BHT-1 and BHG-D1, but the behaviour of them did not depend on their location, what was probably due to the fact that both were drilled in the shay facies of the Opalinus clay. There was not a distinct difference between the results obtained under total or matric suctions. In the drying paths, both the water contents and the degrees of saturation tended to be higher when total suction was applied, however the reverse trend was observed for the water contents reached in wetting paths. As well, no clear difference was observed in the water retention curves obtained in odometers under matric and total suctions, what points to the osmotic component of suction in Opalinus clay not being significant. Overall, the water contents were lower and the degrees of saturation higher when suction was applied under vertical stress, what would indicate that the water retention capacity was lower under 8 MPa vertical stress than under free volume conditions. This vertical stress value is slightly higher than the maximum in situ stress. Also, the samples showed hysteresis according to the expected behaviour, i.e. the water contents for a given suction were higher during a drying path than during a wetting path. The P values obtained were between 6 and 34 MPa, and tended to be higher for the samples tested under stress, in drying paths and when total suction was used. The air entry value calculated from the mercury intrusion porosimetry

  7. Relation among C-curve characterization diagrams

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    As three control points are fixed and the fourth control point varies, the planar cubic C-curve may take on a loop, a cusp, or zero to two inflection points, depending on the position of the moving point. The plane can, therefore, be partitioned into regions labelled according to the characterization of the curve when the fourth point is in each region. This partitioned plane is called a "characterization diagram". By moving one of the control points but fixing the rest, one can induce different characterization diagrams. In this paper, we investigate the relation among all different characterization diagrams of cubic C-curves based on the singularity conditions proposed by Yang and Wang (2004). We conclude that, no matter what the C-curve type is or which control point varies, the characterization diagrams can be obtained by cutting a common 3D characterization space with a corresponding plane.

  8. Holomorphic Cartan geometries and rational curves

    CERN Document Server

    Biswas, Indranil

    2010-01-01

    We prove that any compact K\\"ahler manifold bearing a holomorphic Cartan geometry contains a rational curve just when the Cartan geometry is inherited from a holomorphic Cartan geometry on a lower dimensional compact K\\"ahler manifold.

  9. Transmission of wave energy in curved ducts

    Science.gov (United States)

    Rostafinski, W.

    1973-01-01

    A formation of wave energy flow was developed for motion in curved ducts. A parametric study over a range of frequencies determined the ability of circular bends to transmit energy for the case of perfectly rigid walls.

  10. Twisted Vector Bundles on Pointed Nodal Curves

    Indian Academy of Sciences (India)

    Ivan Kausz

    2005-05-01

    Motivated by the quest for a good compactification of the moduli space of -bundles on a nodal curve we establish a striking relationship between Abramovich’s and Vistoli’s twisted bundles and Gieseker vector bundles.

  11. ARC Code TI: ROC Curve Code Augmentation

    Data.gov (United States)

    National Aeronautics and Space Administration — ROC (Receiver Operating Characteristic) curve Code Augmentation was written by Rodney Martin and John Stutz at NASA Ames Research Center and is a modification of ROC...

  12. Bounded Population Growth: A Curve Fitting Lesson.

    Science.gov (United States)

    Mathews, John H.

    1992-01-01

    Presents two mathematical methods for fitting the logistic curve to population data supplied by the U.S. Census Bureau utilizing computer algebra software to carry out the computations and plot graphs. (JKK)

  13. Rational Curves on Calabi-Yau Threefolds

    CERN Document Server

    Katz, S

    1992-01-01

    The point is to compare the mathematical meaning of the ``number of rational curves on a Calabi-Yau threefold'' to the meaning ascribed to the same notion by string theorists. By considering mirror symmetry applied to conformal field theories corresponding to strings propagating in quintic hypersurfaces in projective 4-space, Candelas, de la Ossa, Green and Parkes calculated the ``number of rational curves on the hypersurface'' by comparing three point functions. Actually, the number of curves may be infinite for special examples; what is really being calculated is a path integral. The point of this talk is to give mathematical techniques and examples for computing the finite number that ``should'' correspond to an infinite family of curves (which coincides with that given by the path integral in every known instance), and to suggest that these techniques should provide the answer to the not yet solved problem of how to calculate instanton corrections to the three point function in general.

  14. Quaternion orders, quadratic forms, and Shimura curves

    CERN Document Server

    Alsina, Montserrat

    2004-01-01

    Shimura curves are a far-reaching generalization of the classical modular curves. They lie at the crossroads of many areas, including complex analysis, hyperbolic geometry, algebraic geometry, algebra, and arithmetic. The text provides an introduction to the subject from a theoretic and algorithmic perspective. The main topics covered in it are Shimura curves defined over the rational number field, the construction of their fundamental domains, and the determination of their complex multiplication points. The study of complex multiplication points in Shimura curves leads to the study of families of binary quadratic forms with algebraic coefficients and to their classification by arithmetic Fuchsian groups. In this regard, the authors develop a theory full of new possibilities which parallels Gauss' theory on the classification of binary quadratic forms with integral coefficients by the action of the modular group. Each topic covered in the book begins with a theoretical discussion followed by carefully worked...

  15. Galactic rotation curves and brane world models

    CERN Document Server

    Rahaman, F; De Benedictis, A; Usmani, A A; Ray, Saibal

    2008-01-01

    In the present investigation flat rotational curves of the galaxies are considered under the framework of brane-world models where the 4d effective Einstein equation has extra terms which arise from the embedding of the 3-brane in the $5d$ bulk. It has been shown here that these long range bulk gravitational degrees of freedom can act as a mechanism to yield the observed galactic rotation curves without the need for dark matter. The present model has the advantage that the observed rotation curves result solely from well-established non-local effects of gravitation, such as dark radiation and dark pressure under a direct use of the condition of flat rotation curves and does not invoke any exotic matter field.

  16. Solid-state curved focal plane arrays

    Science.gov (United States)

    Nikzad, Shouleh (Inventor); Hoenk, Michael (Inventor); Jones, Todd (Inventor)

    2010-01-01

    The present invention relates to curved focal plane arrays. More specifically, the present invention relates to a system and method for making solid-state curved focal plane arrays from standard and high-purity devices that may be matched to a given optical system. There are two ways to make a curved focal plane arrays starting with the fully fabricated device. One way, is to thin the device and conform it to a curvature. A second way, is to back-illuminate a thick device without making a thinned membrane. The thick device is a special class of devices; for example devices fabricated with high purity silicon. One surface of the device (the non VLSI fabricated surface, also referred to as the back surface) can be polished to form a curved surface.

  17. Rank of K2 of elliptic curves

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    We prove that (i) rank(K2(E)) 1 for all elliptic curves E defined over Q with a rational torsion point of exact order N 4; (ii) rank(K2(E)) 1 for all but at most one R-isomorphism class of elliptic curves E defined over Q with a rational torsion point of exact order 3. We give some sufficient conditions for rank(K2(EZ)) 1.

  18. Chiral gap effect in curved space

    CERN Document Server

    Flachi, Antonino

    2014-01-01

    We discuss a new type of QCD phenomenon induced in curved space. In the QCD vacuum a mass gap of Dirac fermions is attributed to the spontaneous breaking of chiral symmetry. If the curvature is positive large, the chiral condensate melts but a chiral invariant mass gap can still remain, which we name the chiral gap effect in curved space. This leads to decoupling of quark deconfinement which implies a view of black holes surrounded by a first-order QCD phase transition.

  19. Rank of K2 of elliptic curves

    Institute of Scientific and Technical Information of China (English)

    JI QingZhong; QIN HouRong

    2009-01-01

    We prove that (i) rank(K2(E))≥1 for all elliptic curves E defined over Q with a rational torsion point of exact order N≥ 4;(ii) rank(K2(E))≥1 for all but at most one R-isomorphism class of elliptic curves E defined over Q with a rational torsion point of exact order 3.We give some sufficient conditions for rank(K2(Ez))≥1.

  20. On the Light Curves of AM CVn

    CERN Document Server

    Smak, J

    2016-01-01

    Light curves of AM CVn are analyzed by decomposing them into their Fourier components. The amplitudes of the fundamental mode and overtones of the three components: the superhumps, the negative superhumps and the orbital variations, are found to be variable. This implies that variations in the shape of the observed light curve of AM CVn are not only due to the interference between those components, but also due to the variability of their parameters.