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Sample records for kantowski sachs cosmology

  1. Kantowski--Sachs cosmological models as big-bang models

    International Nuclear Information System (INIS)

    Weber, E.

    1985-01-01

    In the presence of a nonzero cosmological constant Λ, we classify the anisotropic cosmological models of the Kantowski--Sachs type by means of the quantities epsilon 2 0 , q 0 , summation 0 corresponding, respectively, to the relative root-mean-square deviation from isotropy, the deceleration parameter, and the density parameter of the perfect fluid at a given time t = t 0 . We obtain for Λ>0 a set of big-bang models of zero measure as well as a set of cosmological models of nonzero measure evolving toward the de Sitter solution

  2. Gravitational, shear and matter waves in Kantowski-Sachs cosmologies

    Energy Technology Data Exchange (ETDEWEB)

    Keresztes, Zoltán; Gergely, László Á. [Department of Theoretical Physics, University of Szeged, Tisza Lajos krt 84-86, Szeged 6720 (Hungary); Forsberg, Mats; Bradley, Michael [Department of Physics, UmeåUniversity (Sweden); Dunsby, Peter K.S., E-mail: zkeresztes@titan.physx.u-szeged.hu, E-mail: forsberg.mats.a.b@gmail.com, E-mail: michael.bradley@physics.umu.se, E-mail: peter.dunsby@uct.ac.za, E-mail: gergely@physx.u-szeged.hu [Astrophysics, Cosmology and Gravity Centre (ACGC), University of Cape Town, Rondebosch 7701, Cape Town (South Africa)

    2015-11-01

    A general treatment of vorticity-free, perfect fluid perturbations of Kantowski-Sachs models with a positive cosmological constant are considered within the framework of the 1+1+2 covariant decomposition of spacetime. The dynamics is encompassed in six evolution equations for six harmonic coefficients, describing gravito-magnetic, kinematic and matter perturbations, while a set of algebraic expressions determine the rest of the variables. The six equations further decouple into a set of four equations sourced by the perfect fluid, representing forced oscillations and two uncoupled damped oscillator equations. The two gravitational degrees of freedom are represented by pairs of gravito-magnetic perturbations. In contrast with the Friedmann case one of them is coupled to the matter density perturbations, becoming decoupled only in the geometrical optics limit. In this approximation, the even and odd tensorial perturbations of the Weyl tensor evolve as gravitational waves on the anisotropic Kantowski-Sachs background, while the modes describing the shear and the matter density gradient are out of phase dephased by π /2 and share the same speed of sound.

  3. Bianchi - I, II, VIII, IX and Kantowski-Sachs-like cosmological models with perfect fluid and electromagnetic fields with conductivity current

    International Nuclear Information System (INIS)

    Portugal, R.

    1984-01-01

    Three processes of solutions of the Einstein-Maxwell equations for Bianchi - I, II, VIII, IX and Kantowski-Sachs-like cosmological models with perfect fluid in magnetohydrolodynamical regimem are presented. Diagonal Bianchi-like models are considered with two anisotropy direction in the maximum. Solutions are found for Bianchi-II and IX-like models with energy conditions to be analyzed. Solutions are found for Bianchi-IX and Kantowski-Sachs-Like models with positive electric conductivity and satisfering to the predominant energy conditions. Solutions are formed for isotropic Kantowski-Sachs-Like models satisfering to the equation of state p=λρ, 0 0, admiting, in addition to the perfect fluid, electric field only. It is shown that a class of Bertotti-Robinson-like solutions is unstable by perturbations and it is carried in Kantowski-Sachs-like models with non-null electric conductivity. (L.C.) [pt

  4. Exact Kantowski-Sachs and Bianchi types I and III cosmological models with a conformally invariant scalar field

    International Nuclear Information System (INIS)

    Accioly, A.J.

    1985-01-01

    Exact solutions of the Einstein-Conformally Invariant Scalar Field Equations are obtained for Kantowski-Sachs and Bianchi types I and III cosmologies. The presence of the conformally invariant scalar field is responsible for some interesting features of the solutions. In particular it is found that the Bianchi I model is consistent with the big-bang theory of cosmology. (Author) [pt

  5. Phenomenological dynamics of loop quantum cosmology in Kantowski-Sachs spacetime

    International Nuclear Information System (INIS)

    Chiou, D.-W.

    2008-01-01

    The fundamental theory and the semiclassical description of loop quantum cosmology (LQC) have been studied in the Friedmann-Robertson-Walker and Bianchi I models. As an extension to include both anisotropy and intrinsic curvature, this paper investigates the cosmological model of Kantowski-Sachs spacetime with a free massless scalar field at the level of phenomenological dynamics with the LQC discreteness corrections. The LQC corrections are implemented in two different improved quantization schemes. In both schemes, the big bang and big crunch singularities of the classical solution are resolved and replaced by the big bounces when the area or volume scale factor approaches the critical values in the Planck regime measured by the reference of the scalar field momentum. Symmetries of scaling are also noted and suggest that the fundamental spatial scale (area gap) may give rise to a temporal scale. The bouncing scenarios are in an analogous fashion of the Bianchi I model, naturally extending the observations obtained previously.

  6. Quantum field theory of the universe in the Kantowski-Sachs space-time

    International Nuclear Information System (INIS)

    Shen, Y.; Tan, Z.

    1996-01-01

    In this paper, the quantum field theory of the universe in the Kantowski-Sachs space-time is studied. An analogue of proceedings in quantum field theory is applied in curved space-time to the Kantowski-Sachs space-time, obtaining the wave function of the universe satisfied the Wheeler-DeWitt equation. Regarding the wave function as a universe field in the minisuperspace, the authors can not only overcome the difficulty of the probabilistic interpretation in quantum cosmology, but also come to the conclusion that there is multiple production of universes. The average number of the produced universes from nothing is calculated. The distribution of created universe is given. It is the Planckian distribution

  7. Kantowski-Sachs multidimensional cosmological models and dynamical dimensional reduction

    International Nuclear Information System (INIS)

    Demianski, M.; Rome Univ.; Golda, Z.A.; Heller, M.; Szydlowski, M.

    1988-01-01

    Einstein's field equations are solved for a multidimensional spacetime (KS) x Tsup(m), where (KS) is a four-dimensional Kantowski-Sachs spacetime and Tsup(m) is an m-dimensional torus. Among all possible vacuum solutions there is a large class of spacetimes in which the macroscopic space expands and the microscopic space contracts to a finite volume. We also consider a non-vacuum case and we explicitly solve the field equations for the matter satisfying the Zel'dovich equation of state. In non-vacuum models, with matter satisfying an equation of state p = γρ, O ≤ γ < 1, at a sufficiently late stage of evolution the microspace always expands and the dynamical dimensional reduction does not occur. (author)

  8. Relativistic cosmologies with closed, locally homogeneous space sections

    International Nuclear Information System (INIS)

    Fagundes, H.V.

    1985-01-01

    The homogeneous Bianchi and Kantowski-Sachs metrics of relativistic cosmology are investigated through their correspondence with recent geometrical results of Thurston. These allow a partial classification of the topologies for closed, locally homogeneous spaces according to Thurston's eight geometric types. Besides, which of the Bianchi-Kantowski-Sachs metrics can be imposed on closed space sections of cosmological models are learned. This is seen as a progress toward implementation of a postulate of the closure of space for both classical and quantum gravity. (Author) [pt

  9. Kantowski-Sachs Einstein-æther perfect fluid models

    Energy Technology Data Exchange (ETDEWEB)

    Latta, Joey [Department of Mathematics and Statistics, Dalhousie University, Halifax, Nova Scotia, B3H 3J5 (Canada); Leon, Genly [Instituto de Física, Pontificia Universidad de Católica de Valparaíso, Casilla 4950, Valparaíso (Chile); Paliathanasis, Andronikos, E-mail: lattaj@mathstat.dal.ca, E-mail: genly.leon@pucv.cl, E-mail: anpaliat@phys.uoa.gr [Instituto de Ciencias Físicas y Matemáticas, Universidad Austral de Chile, Valdivia (Chile)

    2016-11-01

    We investigate Kantowski-Sachs models in Einstein-æ ther theory with a perfect fluid source using the singularity analysis to prove the integrability of the field equations and dynamical system tools to study the evolution. We find an inflationary source at early times, and an inflationary sink at late times, for a wide region in the parameter space. The results by A.A. Coley, G. Leon, P. Sandin and J. Latta ( JCAP 12 (2015) 010), are then re-obtained as particular cases. Additionally, we select other values for the non-GR parameters which are consistent with current constraints, getting a very rich phenomenology. In particular, we find solutions with infinite shear, zero curvature, and infinite matter energy density in comparison with the Hubble scalar. We also have stiff-like future attractors, anisotropic late-time attractors, or both, in some special cases. Such results are developed analytically, and then verified by numerics. Finally, the physical interpretation of the new critical points is discussed.

  10. Time-dependent automorphism-inducing diffeomorphisms, open algebras and the generality of the Kantowski-Sachs vacuum geometry

    Science.gov (United States)

    Christodoulakis, T.; Papadopoulos, G. O.

    2002-10-01

    Following the spirit of a previous work of ours, we investigate the group of those general coordinate transformations (GCTs) which preserve manifest spatial homogeneity. In contrast to the case of Bianchi type models, here we permit an isometry group of motions G4 = SO(3) ⊗ Tr, where Tr is the translations group, along the radial direction, while SO(3) acts multiply transitively on each hypersurface of simultaneity Σt. The basis 1-forms cannot be invariant under the action of the entire isometry group and hence produce an open Lie algebra. In order for these GCTs to exist and have a nontrivial, well-defined action, certain integrability conditions have to be satisfied; their solutions, exhibiting the maximum expected 'gauge' freedom, can be used to simplify the generic, spatially homogeneous, line element. In this way an alternative proof of the generality of the Kantowski-Sachs (KS) vacuum is given, while its most general, manifestly homogeneous, form is explicitly presented.

  11. Classification of Kantowski-Sachs and Bianchi Type III Space-Times According to Their Killing Vector Fields in Teleparallel Theory of Gravitation

    International Nuclear Information System (INIS)

    Shabbir, Ghulam; Khan, Suhail

    2010-01-01

    In this paper we classify Kantowski-Sachs and Bianchi type III space-times according to their teleparallel Killing vector fields using direct integration technique. It turns out that the dimension of the teleparallel Killing vector fields are 4 or 6, which are the same in numbers as in general relativity. In case of 4 the teleparallel Killing vector fields are multiple of the corresponding Killing vector fields in general relativity by some function of t. In the case of 6 Killing vector fields the metric functions become constants and the Killing vector fields in this case are exactly the same as in general relativity. Here we also discuss the Lie algebra in each case. (general)

  12. Self-similar cosmological solutions with dark energy. I. Formulation and asymptotic analysis

    International Nuclear Information System (INIS)

    Harada, Tomohiro; Maeda, Hideki; Carr, B. J.

    2008-01-01

    Based on the asymptotic analysis of ordinary differential equations, we classify all spherically symmetric self-similar solutions to the Einstein equations which are asymptotically Friedmann at large distances and contain a perfect fluid with equation of state p=(γ-1)μ with 0 1). However, in the latter case there is an additional parameter associated with the weak discontinuity at the sonic point and the solutions are only asymptotically 'quasi-Friedmann', in the sense that they exhibit an angle deficit at large distances. In the 0<γ<2/3 case, there is no sonic point and there exists a one-parameter family of solutions which are genuinely asymptotically Friedmann at large distances. We find eight classes of asymptotic behavior: Friedmann or quasi-Friedmann or quasistatic or constant-velocity at large distances, quasi-Friedmann or positive-mass singular or negative-mass singular at small distances, and quasi-Kantowski-Sachs at intermediate distances. The self-similar asymptotically quasistatic and quasi-Kantowski-Sachs solutions are analytically extendible and of great cosmological interest. We also investigate their conformal diagrams. The results of the present analysis are utilized in an accompanying paper to obtain and physically interpret numerical solutions

  13. Integrated Sachs-Wolfe effect versus redshift test for the cosmological parameters

    Science.gov (United States)

    Kantowski, R.; Chen, B.; Dai, X.

    2015-04-01

    We describe a method using the integrated Sachs-Wolfe (ISW) effect caused by individual inhomogeneities to determine the cosmological parameters H0, Ωm , and ΩΛ, etc. This ISW-redshift test requires detailed knowledge of the internal kinematics of a set of individual density perturbations, e.g., galaxy clusters and/or cosmic voids, in particular their density and velocity profiles, and their mass accretion rates. It assumes the density perturbations are isolated and embedded (equivalently compensated) and makes use of the newly found relation between the ISW temperature perturbation of the cosmic microwave background (CMB) and the Fermat potential of the lens. Given measurements of the amplitudes of the temperature variations in the CMB caused by such clusters or voids at various redshifts and estimates of their angular sizes or masses, one can constrain the cosmological parameters. More realistically, the converse is more likely, i.e., if the background cosmology is sufficiently constrained, measurement of ISW profiles of clusters and voids (e.g., hot and cold spots and rings) can constrain dynamical properties of the dark matter, including accretion, associated with such lenses and thus constrain the evolution of these objects with redshift.

  14. Towards N = 2 SUSY homogeneous quantum cosmology; Einstein-Yang-Mills systems

    International Nuclear Information System (INIS)

    Donets, E.E.; Tentyukov, M.N.; Tsulaya, M.M.

    1998-01-01

    The application of N = 2 supersymmetric Quantum Mechanics for the quantization of homogeneous systems coupled with gravity is discussed. Starting with the superfield formulation of N = 2 SUSY sigma-model, Hermitian self-adjoint expressions for quantum Hamiltonians and Lagrangians for any signature of a sigma-model metric are obtained. This approach is then applied to coupled SU (2) Einstein-Yang-Mills (EYM) systems in axially-symmetric Bianchi - I,II,VIII, IX, Kantowski-Sachs and closed Friedmann-Robertson-Walker cosmological models. It is shown that all these models admit the embedding into N = 2 SUSY sigma-model with the explicit expressions for superpotentials, being direct sums of gravitational and Yang-Mills (YM) parts. In addition, YM parts of superpotentials exactly coincide with the corresponding Chern-Simons terms. The spontaneous SUSY breaking, caused by YM instantons in EYM systems is discussed in a number of examples

  15. Noncommutative black holes

    Energy Technology Data Exchange (ETDEWEB)

    Lopez-DomInguez, J C [Instituto de Fisica de la Universidad de Guanajuato PO Box E-143, 37150 Leoen Gto. (Mexico); Obregon, O [Instituto de Fisica de la Universidad de Guanajuato PO Box E-143, 37150 Leoen Gto. (Mexico); RamIrez, C [Facultad de Ciencias FIsico Matematicas, Universidad Autonoma de Puebla, PO Box 1364, 72000 Puebla (Mexico); Sabido, M [Instituto de Fisica de la Universidad de Guanajuato PO Box E-143, 37150 Leoen Gto. (Mexico)

    2007-11-15

    We study noncommutative black holes, by using a diffeomorphism between the Schwarzschild black hole and the Kantowski-Sachs cosmological model, which is generalized to noncommutative minisuperspace. Through the use of the Feynman-Hibbs procedure we are able to study the thermodynamics of the black hole, in particular, we calculate Hawking's temperature and entropy for the 'noncommutative' Schwarzschild black hole.

  16. SAChES: Scalable Adaptive Chain-Ensemble Sampling.

    Energy Technology Data Exchange (ETDEWEB)

    Swiler, Laura Painton [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Ray, Jaideep [Sandia National Lab. (SNL-CA), Livermore, CA (United States); Ebeida, Mohamed Salah [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Huang, Maoyi [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Hou, Zhangshuan [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Bao, Jie [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Ren, Huiying [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2017-08-01

    We present the development of a parallel Markov Chain Monte Carlo (MCMC) method called SAChES, Scalable Adaptive Chain-Ensemble Sampling. This capability is targed to Bayesian calibration of com- putationally expensive simulation models. SAChES involves a hybrid of two methods: Differential Evo- lution Monte Carlo followed by Adaptive Metropolis. Both methods involve parallel chains. Differential evolution allows one to explore high-dimensional parameter spaces using loosely coupled (i.e., largely asynchronous) chains. Loose coupling allows the use of large chain ensembles, with far more chains than the number of parameters to explore. This reduces per-chain sampling burden, enables high-dimensional inversions and the use of computationally expensive forward models. The large number of chains can also ameliorate the impact of silent-errors, which may affect only a few chains. The chain ensemble can also be sampled to provide an initial condition when an aberrant chain is re-spawned. Adaptive Metropolis takes the best points from the differential evolution and efficiently hones in on the poste- rior density. The multitude of chains in SAChES is leveraged to (1) enable efficient exploration of the parameter space; and (2) ensure robustness to silent errors which may be unavoidable in extreme-scale computational platforms of the future. This report outlines SAChES, describes four papers that are the result of the project, and discusses some additional results.

  17. Quantum cosmology of a Bianchi III LRS geometry coupled to a source free electromagnetic field

    Science.gov (United States)

    Karagiorgos, A.; Pailas, T.; Dimakis, N.; Terzis, Petros A.; Christodoulakis, T.

    2018-03-01

    We consider a Bianchi type III axisymmetric geometry in the presence of an electromagnetic field. A first result at the classical level is that the symmetry of the geometry need not be applied on the electromagnetic tensor Fμν the algebraic restrictions, implied by the Einstein field equations to the stress energy tensor Tμν, suffice to reduce the general Fμν to the appropriate form. The classical solution thus found contains a time dependent electric and a constant magnetic charge. The solution is also reachable from the corresponding mini-superspace action, which is strikingly similar to the Reissner-Nordstr{öm one. This points to a connection between the black hole geometry and the cosmological solution here found, which is the analog of the known correlation between the Schwarzschild and the Kantowski-Sachs metrics. The configuration space is drastically modified by the presence of the magnetic charge from a 3D flat to a 3D pp wave geometry. We map the emerging linear and quadratic classical integrals of motion, to quantum observables. Along with the Wheeler-DeWitt equation these observables provide unique, up to constants, wave functions. The employment of a Bohmian interpretation of these quantum states results in deterministic (semi-classical) geometries most of which are singularity free.

  18. Tay-Sachs - resources

    Science.gov (United States)

    The following organizations provide information on Tay-Sachs disease : US National Library of Medicine -- ghr.nlm.nih.gov/condition/tay-sachs-disease March of Dimes -- www.marchofdimes.org/complications/tay-sachs- ...

  19. Emergence of the product of constant curvature spaces in loop quantum cosmology

    International Nuclear Information System (INIS)

    Dadhich, Naresh; Joe, Anton; Singh, Parampreet

    2015-01-01

    The loop quantum dynamics of Kantowski–Sachs spacetime and the interior of higher genus black hole spacetimes with a cosmological constant has some peculiar features not shared by various other spacetimes in loop quantum cosmology. As in the other cases, though the quantum geometric effects resolve the physical singularity and result in a non-singular bounce, after the bounce a spacetime with small spacetime curvature does not emerge in either the subsequent backward or the forward evolution. Rather, in the asymptotic limit the spacetime manifold is a product of two constant curvature spaces. Interestingly, though the spacetime curvature of these asymptotic spacetimes is very high, their effective metric is a solution to Einstein’s field equations. Analysis of the components of the Ricci tensor shows that after the singularity resolution, the Kantowski–Sachs spacetime leads to an effective metric which can be interpreted as the ‘charged’ Nariai, while the higher genus black hole interior can similarly be interpreted as an anti Bertotti–Robinson spacetime with a cosmological constant. These spacetimes are ‘charged’ in the sense that the energy–momentum tensor that satisfies Einstein’s field equations is formally the same as the one for the uniform electromagnetic field, albeit it has a purely quantum geometric origin. The asymptotic spacetimes also have an emergent cosmological constant which is different in magnitude, and sometimes even its sign, from the cosmological constant in the Kantowski–Sachs and the interior of higher genus black hole metrics. With a fine tuning of the latter cosmological constant, we show that ‘uncharged’ Nariai, and anti Bertotti–Robinson spacetimes with a vanishing emergent cosmological constant can also be obtained. (paper)

  20. The theory of stochastic cosmological lensing

    Energy Technology Data Exchange (ETDEWEB)

    Fleury, Pierre; Uzan, Jean-Philippe [Institut d' Astrophysique de Paris, UMR 7095 du CNRS, 98 bis Bd Arago, 75014 Paris (France); Larena, Julien, E-mail: fleury@iap.fr, E-mail: j.larena@ru.ac.za, E-mail: uzan@iap.fr [Department of Mathematics, Rhodes University, Grahamstown 6140 (South Africa)

    2015-11-01

    On the scale of the light beams subtended by small sources, e.g. supernovae, matter cannot be accurately described as a fluid, which questions the applicability of standard cosmic lensing to those cases. In this article, we propose a new formalism to deal with small-scale lensing as a diffusion process: the Sachs and Jacobi equations governing the propagation of narrow light beams are treated as Langevin equations. We derive the associated Fokker-Planck-Kolmogorov equations, and use them to deduce general analytical results on the mean and dispersion of the angular distance. This formalism is applied to random Einstein-Straus Swiss-cheese models, allowing us to: (1) show an explicit example of the involved calculations; (2) check the validity of the method against both ray-tracing simulations and direct numerical integration of the Langevin equation. As a byproduct, we obtain a post-Kantowski-Dyer-Roeder approximation, accounting for the effect of tidal distortions on the angular distance, in excellent agreement with numerical results. Besides, the dispersion of the angular distance is correctly reproduced in some regimes.

  1. Tay-Sachs Disease

    Science.gov (United States)

    Tay-Sachs disease is a rare, inherited disease. It is a type of lipid metabolism disorder. It causes too ... cells, causing mental and physical problems. . Infants with Tay-Sachs disease appear to develop normally for the first few ...

  2. Anisotropic cosmological models and generalized scalar tensor theory

    Indian Academy of Sciences (India)

    Abstract. In this paper generalized scalar tensor theory has been considered in the background of anisotropic cosmological models, namely, axially symmetric Bianchi-I, Bianchi-III and Kortowski–. Sachs space-time. For bulk viscous fluid, both exponential and power-law solutions have been stud- ied and some assumptions ...

  3. Anisotropic cosmological models and generalized scalar tensor theory

    Indian Academy of Sciences (India)

    In this paper generalized scalar tensor theory has been considered in the background of anisotropic cosmological models, namely, axially symmetric Bianchi-I, Bianchi-III and Kortowski–Sachs space-time. For bulk viscous fluid, both exponential and power-law solutions have been studied and some assumptions among the ...

  4. Survey on serum acetylecholinesterase (SAChE activity in selected farming communities at risk of organophosphate exposure, Southern Ghana

    Directory of Open Access Journals (Sweden)

    Ato Kwamena Tetteh

    2017-12-01

    Material and Methods ― The study was cross-sectional, involving 963 participants who consented to being screened for serum acetylcholinesterase (SAChE activity, using the dry chemistry test strips. The SAChE activity was then categorized into normal, low or high risk of developing symptoms associated with OP poisoning. Results ― The total group included 54.5% females and 45.5% males. Majority were crop farmers (46.3% and students/pupils (30.8%. The remaining 22.9% consisted mainly of traders, teachers, fishermen/fish processors, drivers and dressmakers. Very low SAChE activity unit of 30 U/ml. By this, a significant majority had either low or high risk of developing OP poisoning (χ2=4.43, 95%CI: 4.12–4.65, p=0.014 compared with those with normal activity. Most of the participants were in the 10–19 years age group of which 15.6% were in the high risk category, while 13.6% had low risk of OP poisoning. Reduced SAChE activity was predominant among all age groups compared with those with normal activity of the enzyme. As well, 27.3% who were females had reduced SAChE activity rate <30 U/ml (high risk of OP poisoning. Similarly, 23.4% of males were also at high risk of OP poisoning. There was however no statistical significance between the sex with regards to the numbers at risk of OP poisoning (χ2=4.80, 95% CI: 4.25–4.75, p=0.160. Conclusion ― This study provides some evidence of exposure, deduced from reduced SAChE activity, which potentially puts participants at a high risk of developing symptoms associated with OP poisoning. A follow-up study might be able to suggest to physicians in Ghana considering diagnostics of OP poisoning, especially for clients from farming communities where pesticides are used extensively.

  5. Matter sources for a null big bang

    International Nuclear Information System (INIS)

    Bronnikov, K A; Zaslavskii, O B

    2008-01-01

    We consider the properties of stress-energy tensors compatible with a null big bang, i.e., cosmological evolution starting from a Killing horizon rather than a singularity. For Kantowski-Sachs cosmologies, it is shown that if matter satisfies the null energy condition, then (i) regular cosmological evolution can only start from a Killing horizon, (ii) matter is absent at the horizon and (iii) matter can only appear in the cosmological region due to interaction with vacuum. The latter is understood phenomenologically as a fluid whose stress tensor is insensitive to boosts in a particular direction. We also argue that matter is absent in a static region beyond the horizon. All this generalizes the observations recently obtained for a mixture of dust and a vacuum fluid. If, however, we admit the existence of phantom matter, its certain special kinds (with the parameter w ≤ -3) are consistent with a null big bang without interaction with vacuum (or without vacuum fluid at all). Then in the static region there is matter with w ≥ -1/3. Alternatively, the evolution can begin from a horizon in an infinitely remote past, leading to a scenario combining the features of a null big bang and an emergent universe

  6. The metabolism of Tay-Sachs ganglioside: catabolic studies with lysosomal enzymes from normal and Tay-Sachs brain tissue

    Science.gov (United States)

    Tallman, John F.; Johnson, William G.; Brady, Roscoe O.

    1972-01-01

    The catabolism of Tay-Sachs ganglioside, N-acetylgalactosaminyl- (N-acetylneuraminosyl) -galactosylglucosylceramide, has been studied in lysosomal preparations from normal human brain and brain obtained at biopsy from Tay-Sachs patients. Utilizing Tay-Sachs ganglioside labeled with 14C in the N-acetylgalactosaminyl portion or 3H in the N-acetylneuraminosyl portion, the catabolism of Tay-Sachs ganglioside may be initiated by either the removal of the molecule of N-acetylgalactosamine or N-acetylneuraminic acid. The activity of the N-acetylgalactosamine-cleaving enzyme (hexosaminidase) is drastically diminished in such preparations from Tay-Sachs brain whereas the activity of the N-acetylneuraminic acid-cleaving enzyme (neuraminidase) is at a normal level. Total hexosaminidase activity as measured with an artificial fluorogenic substrate is increased in tissues obtained from patients with the B variant form of Tay-Sachs disease and it is virtually absent in the O-variant patients. The addition of purified neuraminidase and various purified hexosaminidases exerted only a minimal synergistic effect on the hydrolysis of Tay-Sachs ganglioside in the lysosomal preparations from the control or patient with the O variant of Tay-Sachs disease. Images PMID:4639018

  7. Recent results and perspectives on cosmology and fundamental physics from microwave surveys

    DEFF Research Database (Denmark)

    Burigana, Carlo; Battistelli, Elia Stefano; Benetti, Micol

    2016-01-01

    Recent cosmic microwave background (CMB) data in temperature and polarization have reached high precision in estimating all the parameters that describe the current so-called standard cosmological model. Recent results about the integrated Sachs-Wolfe (ISW) effect from CMB anisotropies, galaxy su...

  8. Integrated Sachs-Wolfe effect in a quintessence cosmological model: Including anisotropic stress of dark energy

    International Nuclear Information System (INIS)

    Wang, Y. T.; Xu, L. X.; Gui, Y. X.

    2010-01-01

    In this paper, we investigate the integrated Sachs-Wolfe effect in the quintessence cold dark matter model with constant equation of state and constant speed of sound in dark energy rest frame, including dark energy perturbation and its anisotropic stress. Comparing with the ΛCDM model, we find that the integrated Sachs-Wolfe (ISW)-power spectrums are affected by different background evolutions and dark energy perturbation. As we change the speed of sound from 1 to 0 in the quintessence cold dark matter model with given state parameters, it is found that the inclusion of dark energy anisotropic stress makes the variation of magnitude of the ISW source uncertain due to the anticorrelation between the speed of sound and the ratio of dark energy density perturbation contrast to dark matter density perturbation contrast in the ISW-source term. Thus, the magnitude of the ISW-source term is governed by the competition between the alterant multiple of (1+3/2xc-circumflex s 2 ) and that of δ de /δ m with the variation of c-circumflex s 2 .

  9. Ethical Issues with Genetic Testing for Tay-Sachs.

    Science.gov (United States)

    Clayton, Tricia

    Several genetic disorders are specific to Jewish heritage; one of the most devastating is Tay-Sachs disease.Tay-Sachs is a fatal hereditary disease, causing progressive neurological problems for which there is no cure. Ethical issues surrounding genetic testing for Tay-Sachs within the Jewish community continue to be complex and multifaceted. A perspective of Tay-Sachs, using rights-based ethics and virtue ethics as a theoretical framework, is explored.

  10. Spherically symmetric Einstein-aether perfect fluid models

    Energy Technology Data Exchange (ETDEWEB)

    Coley, Alan A.; Latta, Joey [Department of Mathematics and Statistics, Dalhousie University, Halifax, Nova Scotia, B3H 3J5 (Canada); Leon, Genly [Instituto de Física, Pontificia Universidad Católica de Valparaíso, Casilla 4950, Valparaíso (Chile); Sandin, Patrik, E-mail: aac@mathstat.dal.ca, E-mail: genly.leon@ucv.cl, E-mail: patrik.sandin@aei.mpg.de, E-mail: lattaj@mathstat.dal.ca [Max-Planck-Institut für Gravitationsphysik (Albert-Einstein-Institut), Am Mühlenberg 1, D-14476 Potsdam (Germany)

    2015-12-01

    We investigate spherically symmetric cosmological models in Einstein-aether theory with a tilted (non-comoving) perfect fluid source. We use a 1+3 frame formalism and adopt the comoving aether gauge to derive the evolution equations, which form a well-posed system of first order partial differential equations in two variables. We then introduce normalized variables. The formalism is particularly well-suited for numerical computations and the study of the qualitative properties of the models, which are also solutions of Horava gravity. We study the local stability of the equilibrium points of the resulting dynamical system corresponding to physically realistic inhomogeneous cosmological models and astrophysical objects with values for the parameters which are consistent with current constraints. In particular, we consider dust models in (β−) normalized variables and derive a reduced (closed) evolution system and we obtain the general evolution equations for the spatially homogeneous Kantowski-Sachs models using appropriate bounded normalized variables. We then analyse these models, with special emphasis on the future asymptotic behaviour for different values of the parameters. Finally, we investigate static models for a mixture of a (necessarily non-tilted) perfect fluid with a barotropic equations of state and a scalar field.

  11. Prenatal Diagnosis Of Tay-Sachs Disease

    Directory of Open Access Journals (Sweden)

    Özgür Özyüncü

    2010-04-01

    CONCLUSION: Tay-Sachs disease can be diagnosed prenatally by measuring hexosaminidase enzyme activity in fetal tissue samples with an acceptable complication rate. Prenatal diagnosis should be offered to families who have affected siblings with Tay-Sachs disease.

  12. Energy in the Kantowski–Sachs space-time using teleparallel ...

    Indian Academy of Sciences (India)

    Energy in the Kantowski–Sachs space-time using teleparallel geometry ... Kantowski–Sachs metric; teleparallelism; gravitational energy. Abstract. The purpose of this paper is to examine the energy content of the inflationary Universe described by Kantowski–Sachs space-time in quasilocal approach of teleparallel gravity ...

  13. Midisuperspace-induced corrections to the Wheeler De Witt equation

    International Nuclear Information System (INIS)

    Mazzitelli, F.D.

    1992-04-01

    We consider the midisuperspace of four dimensional spherically symmetric metrics and the Kantowski-Sachs minisuperspace contained in it. We discuss the quantization of the midisuperspace using the fact that the dimensionally reduced Einstein Hilbert action becomes a scalar-tensor theory of gravity in two dimensions. We show that the covariant regularization procedure in the midisuperspace induces modifications into the minisuperspace Wheeler De Witt equation. (author). 8 refs

  14. Structural consequences of amino acid substitutions causing Tay-Sachs disease.

    Science.gov (United States)

    Ohno, Kazuki; Saito, Seiji; Sugawara, Kanako; Sakuraba, Hitoshi

    2008-08-01

    To determine the structural changes in the alpha-subunit of beta-hexosaminidase due to amino acid substitutions causing Tay-Sachs disease, we built structural models of mutant alpha-subunits resulting from 33 missense mutations (24 infantile and 9 late-onset), and analyzed the influence of each amino acid replacement on the structure by calculating the number of atoms affected and determining the solvent-accessible surface area of the corresponding amino acid residue in the wild-type alpha-subunit. In the infantile Tay-Sachs group, the number of atoms influenced by a mutation was generally larger than that in the late-onset Tay-Sachs group in both the main chain and the side chain, and residues associated with the mutations found in the infantile Tay-Sachs group tended to be less solvent-accessible than those in the late-onset Tay-Sachs group. Furthermore, color imaging determined the distribution and degree of the structural changes caused by representative amino acid substitutions, and that there were also differences between the infantile and late-onset Tay-Sachs disease groups. Structural study is useful for elucidating the basis of Tay-Sachs disease.

  15. An inducible mouse model of late onset Tay-Sachs disease.

    Science.gov (United States)

    Jeyakumar, Mylvaganam; Smith, David; Eliott-Smith, Elena; Cortina-Borja, Mario; Reinkensmeier, Gabriele; Butters, Terry D; Lemm, Thorsten; Sandhoff, Konrad; Perry, V Hugh; Dwek, Raymond A; Platt, Frances M

    2002-08-01

    Mouse models of the G(M2) gangliosidoses, Tay-Sachs and Sandhoff disease, are null for the hexosaminidase alpha and beta subunits respectively. The Sandhoff (Hexb-/-) mouse has severe neurological disease and mimics the human infantile onset variant. However, the Tay-Sachs (Hexa-/-) mouse model lacks an overt phenotype as mice can partially bypass the blocked catabolic pathway and escape disease. We have investigated whether a subset of Tay-Sachs mice develop late onset disease. We have found that approximately 65% of the mice develop one or more clinical signs of the disease within their natural life span (n = 52, P disease at an earlier age (n = 21, P Tay-Sachs mice confirmed that pregnancy induces late onset Tay-Sachs disease. Onset of symptoms correlated with reduced up-regulation of hexosaminidase B, a component of the bypass pathway.

  16. The National Tay Sachs and Allied Diseases Association.

    Science.gov (United States)

    Zeitlin, Paula

    1986-01-01

    The National Tay-Sachs and Allied Diseases Association is involved in education, research, and prevention of Tay-Sachs, an inherited metabolic disorder which destroys the central nervous system, and over 30 related disorders. The group features a parent peer group network and a support group for carrier couples. (CL)

  17. National Tay-Sachs and Allied Diseases Association, Inc.

    Science.gov (United States)

    Exceptional Parent, 1977

    1977-01-01

    Reviewed are the history and organization, purpose and programs, and public services of the National Tay-Sachs and Allied Diseases Association, an organization geared toward eradicating Tay-Sachs disease (a hereditary disorder affecting primarily Jewish infants which generally leads to deterioration and death by the child's fifth year). (SBH)

  18. [Tay-Sachs disease in non-Jewish infant in Israel].

    Science.gov (United States)

    Nadim, Nasser

    2012-01-01

    Tay-Sachs disease, also known as GM2 gangliosidosis or Hexosaminidase A deficiency is an autosomal recessive genetic fatal disorder. The disease is known to appear in East European Ashkenazi Jews, North African Jews, and Quebec French Canadians exclusively, but, with different frequency and type of mutation. Its most common variant is the infantile type Tay-Sachs disease. Juvenile and late-onset forms of the disease are infrequent and slowly progressive. At nearly 3 to 6 months old, a baby with Tay-Sachs progressively loses his motor skills and attentiveness. Startle responses and hyperreflexia become prominent, especially on eliciting deep patellar and Achilles reflexes, as a consequence of neurodegeneration of the upper motor neuron. Other systemic damage ensues gradually; seizures, blindness, spasticity of limbs, inability to swallow and breathe, and eventually the baby dies at 1-4 years of age. All Tay-Sachs patients have a "cherry red spot", easily seen in the macula area of the retina, using an ophthalmoscope. The "cherry red spot" is the only normal part of the retina in these sick babies. The case presented here emphasizes that Tay-Sachs disease is sometimes misdiagnosed at first visits even by an experienced clinician, because of his lack of awareness that this disease is not exclusively a Jewish disease.

  19. Rapid detection of fetal Mendelian disorders: Tay-Sachs disease.

    Science.gov (United States)

    Guetta, Esther; Peleg, Leah

    2008-01-01

    Tay-Sachs disease is an autosomal recessive storage disease caused by the impaired activity of the lysosomal enzyme hexosaminidase A. In this fatal disease, the sphingolipid GM2 ganglioside accumulates in the neurons. Due to high carrier rates and the severity of the disease, population screening and prenatal diagnosis of Tay-Sachs disease are routinely carried out in Israel. Laboratory diagnosis of Tay-Sachs is carried out with biochemical and DNA-based methods in peripheral and umbilical cord blood, amniotic fluid, and chorionic villi samples. The assay of hexosaminidase A (Hex A) activity is carried out with synthetic substrates, 4-methylumbelliferyl-6-sulfo-N-acetyl-beta-glucosaminide (4-MUGS) and 4-methylumbelliferil-N-acetyl-beta-glucosamine (4-MUG), and the DNA-based analysis involves testing for the presence of specific known mutations in the alpha-subunit gene of Hex A. Prenatal diagnosis of Tay-Sachs disease is accomplished within 24-48 h from sampling. The preferred strategy is to simultaneously carry out enzymatic analysis in the amniotic fluid supernatant or in chorionic villi and molecular DNA-based testing in an amniotic fluid cell-pellet or in chorionic villi.

  20. Tay-Sachs and Sandhoff Diseases

    Science.gov (United States)

    ... more common in these groups: Creole of northern Argentina Metis Indians in Saskatchewan, Canada Lebanese If you or your partner is part of these ethnic groups, or you have a family history of Tay-Sachs disease or Sandhoff disease, tell ...

  1. Enfermedad de Tay-Sachs

    Directory of Open Access Journals (Sweden)

    Albia Josefina Pozo Alonso

    Full Text Available La enfermedad de Tay-Sachs es un trastorno neurodegenerativo progresivo de herencia autosómica recesiva. Se debe a la deficiencia de la enzima β-hexosaminidasa A, que provoca una acumulación de gangliósidos GM2 en los lisosomas. Se incluye dentro de las esfingolipidosis. De las esfingolipidosis que presentan mancha rojo cereza en la mácula, la enfermedad de Tay-Sachs es la única en la que no se evidencia hepatoesplenomegalia. La variante más frecuente se inicia en la lactancia. Se presenta un lactante del sexo masculino al que se le realizó el diagnóstico de esta entidad a los 8 meses de edad. A partir de los 4 meses comenzó a presentar una reacción de sobresalto. A los 6 meses comenzó a perder habilidades previamente adquiridas y crisis epilépticas mioclónicas. Se constató una disminución de la actividad específica de la enzima hexosaminidasa A en leucocitos.

  2. Gravitational Waves from Isolated Systems: Surprising Consequences of a Positive Cosmological Constant.

    Science.gov (United States)

    Ashtekar, Abhay; Bonga, Béatrice; Kesavan, Aruna

    2016-02-05

    There is a deep tension between the well-developed theory of gravitational waves from isolated systems and the presence of a positive cosmological constant Λ, however tiny. In particular a generalization of Einstein's 1918 quadrupole formula that would allow a positive Λ is not yet available. We first explain the principal difficulties and then show that it is possible to overcome them in the weak field limit. These results also provide concrete hints for constructing the Λ>0 generalization of the Bondi-Sachs framework for full, nonlinear general relativity.

  3. Proton MR spectroscopy in three children with Tay-Sachs disease.

    Science.gov (United States)

    Aydin, Kubilay; Bakir, Baris; Tatli, Burak; Terzibasioglu, Ege; Ozmen, Meral

    2005-11-01

    Tay-Sachs disease is an inherited metabolic disease caused by the accumulation of GM(2) gangliosides in the central nervous system. Deficiency of hexosaminidase A leads to the accumulation of gangliosides in neurons, axons and glial cells. To present the cranial MRI and proton MR spectroscopy findings of children of Tay-Sachs disease. Three children aged 10, 20 and 21 months were examined. On T2-weighted MR images there were hyperintense signal changes in the basal ganglia and cerebral white matter. MR spectroscopy demonstrated an increase in myoinositol/creatine and choline/creatine ratios with a decrease in the N-acetyl aspartate/creatine ratio. The spectroscopy findings support demyelination, gliosis and neuronal loss in the neuropathological process of Tay-Sachs disease.

  4. Proton MR spectroscopy in three children with Tay-Sachs disease

    Energy Technology Data Exchange (ETDEWEB)

    Aydin, Kubilay; Bakir, Baris; Terzibasioglu, Ege [Istanbul University, Neuroradiology Division, Department of Radiology, Istanbul (Turkey); Tatli, Burak; Ozmen, Meral [Istanbul University, Department of Paediatric Neurology, Istanbul (Turkey)

    2005-11-01

    Tay-Sachs disease is an inherited metabolic disease caused by the accumulation of GM{sub 2} gangliosides in the central nervous system. Deficiency of hexosaminidase A leads to the accumulation of gangliosides in neurons, axons and glial cells. To present the cranial MRI and proton MR spectroscopy findings of children of Tay-Sachs disease. Three children aged 10, 20 and 21 months were examined. On T2-weighted MR images there were hyperintense signal changes in the basal ganglia and cerebral white matter. MR spectroscopy demonstrated an increase in myoinositol/creatine and choline/creatine ratios with a decrease in the N-acetyl aspartate/creatine ratio. The spectroscopy findings support demyelination, gliosis and neuronal loss in the neuropathological process of Tay-Sachs disease. (orig.)

  5. Proton MR spectroscopy in three children with Tay-Sachs disease

    International Nuclear Information System (INIS)

    Aydin, Kubilay; Bakir, Baris; Terzibasioglu, Ege; Tatli, Burak; Ozmen, Meral

    2005-01-01

    Tay-Sachs disease is an inherited metabolic disease caused by the accumulation of GM 2 gangliosides in the central nervous system. Deficiency of hexosaminidase A leads to the accumulation of gangliosides in neurons, axons and glial cells. To present the cranial MRI and proton MR spectroscopy findings of children of Tay-Sachs disease. Three children aged 10, 20 and 21 months were examined. On T2-weighted MR images there were hyperintense signal changes in the basal ganglia and cerebral white matter. MR spectroscopy demonstrated an increase in myoinositol/creatine and choline/creatine ratios with a decrease in the N-acetyl aspartate/creatine ratio. The spectroscopy findings support demyelination, gliosis and neuronal loss in the neuropathological process of Tay-Sachs disease. (orig.)

  6. A critique of Jeffrey D. Sachs's The end of poverty.

    Science.gov (United States)

    Henwood, Doug

    2006-01-01

    Jeffrey Sachs's The End of Poverty is a manifesto and how-to guide on ending extreme poverty around the world; it promotes the U.N. Millennium Development Goals. Sachs achieved fame with his policy package for the "stabilization" of Bolivia (which did nothing to relieve Bolivia's poverty), and became advisor to the Yeltsin government in Russia and to Poland, Slovenia, and Estonia as they began their transitions to capitalism (the last three mixed successes; Russia a thorough disaster). Sachs later became more prominent as a critic of development orthodoxy, and was economic advisor to the Jubilee 2000 movement. The End of Poverty is full of sharp critiques of Western imperialism, but his views on the rest of the development business are more conventional.

  7. Effective gene therapy in an authentic model of Tay-Sachs-related diseases.

    Science.gov (United States)

    Cachón-González, M Begoña; Wang, Susan Z; Lynch, Andrew; Ziegler, Robin; Cheng, Seng H; Cox, Timothy M

    2006-07-05

    Tay-Sachs disease is a prototypic neurodegenerative disease. Lysosomal storage of GM2 ganglioside in Tay-Sachs and the related disorder, Sandhoff disease, is caused by deficiency of beta-hexosaminidase A, a heterodimeric protein. Tay-Sachs-related diseases (GM2 gangliosidoses) are incurable, but gene therapy has the potential for widespread correction of the underlying lysosomal defect by means of the secretion-recapture cellular pathway for enzymatic complementation. Sandhoff mice, lacking the beta-subunit of hexosaminidase, manifest many signs of classical human Tay-Sachs disease and, with an acute course, die before 20 weeks of age. We treated Sandhoff mice by stereotaxic intracranial inoculation of recombinant adeno-associated viral vectors encoding the complementing human beta-hexosaminidase alpha and beta subunit genes and elements, including an HIV tat sequence, to enhance protein expression and distribution. Animals survived for >1 year with sustained, widespread, and abundant enzyme delivery in the nervous system. Onset of the disease was delayed with preservation of motor function; inflammation and GM2 ganglioside storage in the brain and spinal cord was reduced. Gene delivery of beta-hexosaminidase A by using adeno-associated viral vectors has realistic potential for treating the human Tay-Sachs-related diseases.

  8. Sachês antimicrobianos em pós-colheita de manga

    Directory of Open Access Journals (Sweden)

    Eber Antonio Alves Medeiros

    2011-10-01

    Full Text Available Objetivou-se com este trabalho desenvolver sachês incorporados com óleos essenciais avaliando as propriedades físico-químicas e microbiológicas de mangas armazenadas em saco de papel contendo estes sachês em seu interior. Os óleos essenciais de orégano (Origanum vulgaris e capim-limão (Cymbopogon citratus foram incorporados em saches, e sua atividade antimicrobiana foi testada nos fungos Colletotrichum gloeosporides, Lasiodiplodia theobromae, Xanthomonas campestris pv. mangiferae indica, Alternaria alternata. Frutos de manga 'Tommy Atkins' foram acondicionados individualmente em sacos de papel contendo em seu interior um sachê antimicrobiano e mantidos a 25 °C ± 2 °C e UR 80% ± 5% por nove dias. Os parâmetros cor da epiderme, firmeza de polpa, sólidos solúveis, acidez titulável e pH sofreram pouca influência dos óleos essenciais de orégano e capim limão, indicando que a presença do óleo essencial não altera as características físico-químicas da polpa de manga. Os sachês ativos incorporados com óleos essenciais de orégano e capim limão apresentaram controle no crescimento dos microrganismos testados, sendo o capim-limão mais eficiente, reduzindo em aproximadamente 2 ciclos Log a contagem de mesófilos aeróbios e fungos filamentosos e leveduras em relação ao tratamento controle empregado.

  9. 'Cherry red spot' in a patient with Tay-Sachs disease: case report.

    Science.gov (United States)

    Aragão, Ricardo Evangelista Marrocos de; Ramos, Régia Maria Gondim; Pereira, Felipe Bezerra Alves; Bezerra, Andreya Ferreira Rodrigues; Fernandes, Daniel Nogueira

    2009-01-01

    Tay-Sachs disease is an autosomal recessive disorder of sphingolipid metabolism, caused by enzyme hexosaminidase A deficiency that leads to an accumulation of GM2 in neurocytes which results in progressive loss of neurological function. The accumulation of lipid in retinal ganglion cells that leads to a chalk-white appearance of the fundus called 'cherry red spot' is the hallmark of Tay-Sachs disease. It is also seen in others neurometabolic diseases as well as in central retinal artery occlusion. This case reports a child with Tay-Sachs disease in a family with four previous similar deaths without diagnostic.

  10. Basic versus applied research: Julius Sachs (1832-1897) and the experimental physiology of plants.

    Science.gov (United States)

    Kutschera, Ulrich

    2015-01-01

    The German biologist Julius Sachs was the first to introduce controlled, accurate, quantitative experimentation into the botanical sciences, and is regarded as the founder of modern plant physiology. His seminal monograph Experimental-Physiologie der Pflanzen (Experimental Physiology of Plants) was published 150 y ago (1865), when Sachs was employed as a lecturer at the Agricultural Academy in Poppelsdorf/Bonn (now part of the University). This book marks the beginning of a new era of basic and applied plant science. In this contribution, I summarize the achievements of Sachs and outline his lasting legacy. In addition, I show that Sachs was one of the first biologists who integrated bacteria, which he considered to be descendants of fungi, into the botanical sciences and discussed their interaction with land plants (degradation of wood etc.). This "plant-microbe-view" of green organisms was extended and elaborated by the laboratory botanist Wilhelm Pfeffer (1845-1920), so that the term "Sachs-Pfeffer-Principle of Experimental Plant Research" appears to be appropriate to characterize this novel way of performing scientific studies on green, photoautotrophic organisms (embryophytes, algae, cyanobacteria).

  11. Unified treatment of the luminosity distance in cosmology

    International Nuclear Information System (INIS)

    Yoo, Jaiyul; Scaccabarozzi, Fulvio

    2016-01-01

    Comparing the luminosity distance measurements to its theoretical predictions is one of the cornerstones in establishing the modern cosmology. However, as shown in Biern and Yoo, its theoretical predictions in literature are often plagued with infrared divergences and gauge-dependences. This trend calls into question the sanity of the methods used to derive the luminosity distance. Here we critically investigate four different methods—the geometric approach, the Sachs approach, the Jacobi mapping approach, and the geodesic light cone (GLC) approach to modeling the luminosity distance, and we present a unified treatment of such methods, facilitating the comparison among the methods and checking their sanity. All of these four methods, if exercised properly, can be used to reproduce the correct description of the luminosity distance.

  12. Unified treatment of the luminosity distance in cosmology

    Energy Technology Data Exchange (ETDEWEB)

    Yoo, Jaiyul; Scaccabarozzi, Fulvio, E-mail: jyoo@physik.uzh.ch, E-mail: fulvio@physik.uzh.ch [Center for Theoretical Astrophysics and Cosmology, Institute for Computational Science, University of Zürich, Zürich (Switzerland)

    2016-09-01

    Comparing the luminosity distance measurements to its theoretical predictions is one of the cornerstones in establishing the modern cosmology. However, as shown in Biern and Yoo, its theoretical predictions in literature are often plagued with infrared divergences and gauge-dependences. This trend calls into question the sanity of the methods used to derive the luminosity distance. Here we critically investigate four different methods—the geometric approach, the Sachs approach, the Jacobi mapping approach, and the geodesic light cone (GLC) approach to modeling the luminosity distance, and we present a unified treatment of such methods, facilitating the comparison among the methods and checking their sanity. All of these four methods, if exercised properly, can be used to reproduce the correct description of the luminosity distance.

  13. Cosmological signatures of anisotropic spatial curvature

    International Nuclear Information System (INIS)

    Pereira, Thiago S.; Marugán, Guillermo A. Mena; Carneiro, Saulo

    2015-01-01

    If one is willing to give up the cherished hypothesis of spatial isotropy, many interesting cosmological models can be developed beyond the simple anisotropically expanding scenarios. One interesting possibility is presented by shear-free models in which the anisotropy emerges at the level of the curvature of the homogeneous spatial sections, whereas the expansion is dictated by a single scale factor. We show that such models represent viable alternatives to describe the large-scale structure of the inflationary universe, leading to a kinematically equivalent Sachs-Wolfe effect. Through the definition of a complete set of spatial eigenfunctions we compute the two-point correlation function of scalar perturbations in these models. In addition, we show how such scenarios would modify the spectrum of the CMB assuming that the observations take place in a small patch of a universe with anisotropic curvature

  14. Cosmological signatures of anisotropic spatial curvature

    Energy Technology Data Exchange (ETDEWEB)

    Pereira, Thiago S. [Departamento de Física, Universidade Estadual de Londrina, 86057-970, Londrina – PR (Brazil); Marugán, Guillermo A. Mena [Instituto de Estructura de la Materia, IEM-CSIC, Serrano 121, 28006, Madrid (Spain); Carneiro, Saulo, E-mail: tspereira@uel.br, E-mail: mena@iem.cfmac.csic.es, E-mail: saulo.carneiro@pq.cnpq.br [Instituto de Física, Universidade Federal da Bahia, 40210-340, Salvador – BA (Brazil)

    2015-07-01

    If one is willing to give up the cherished hypothesis of spatial isotropy, many interesting cosmological models can be developed beyond the simple anisotropically expanding scenarios. One interesting possibility is presented by shear-free models in which the anisotropy emerges at the level of the curvature of the homogeneous spatial sections, whereas the expansion is dictated by a single scale factor. We show that such models represent viable alternatives to describe the large-scale structure of the inflationary universe, leading to a kinematically equivalent Sachs-Wolfe effect. Through the definition of a complete set of spatial eigenfunctions we compute the two-point correlation function of scalar perturbations in these models. In addition, we show how such scenarios would modify the spectrum of the CMB assuming that the observations take place in a small patch of a universe with anisotropic curvature.

  15. "Cherry red spot" in a patient with Tay-Sachs disease: case report "Mácula em cereja" em paciente com doença de Tay-Sachs: relato de caso

    Directory of Open Access Journals (Sweden)

    Ricardo Evangelista Marrocos de Aragão

    2009-08-01

    Full Text Available Tay-Sachs disease is an autosomal recessive disorder of sphingolipid metabolism, caused by enzime hexosaminidase A deficiency that leads to an accumulation of GM2 in neurocytes which results in progressive loss of neurological function. The accumulation of lipid in retinal ganglion cells that leads to a chalk-white appearance of the fundus called "cherry red spot" is the hallmark of Tay-Sachs disease. It is also seen in others neurometabolic diseases as well as in central retinal artery occlusion. This case reports a child with Tay-Sachs disease in a family with four previous similar deaths without diagnostic.Tay-Sachs é uma doença autossômica recessiva, caracterizada pela deficiência da enzima hexosaminidase A levando ao acúmulo de esfingolipídios (GM2 em células neuronais que resulta em uma perda progressiva da função neurológica. O acúmulo de lipídios em células ganglionais da retina leva a uma aparência de mácula em cereja, característica do fundo de olho de pessoas acometidas. "Mácula em cereja" também pode ser vista em outras doenças neurometabólicas e em oclusão da artéria central da retina. Este trabalho relata o caso de um paciente com doença de Tay-Sachs em uma família com história de quatro óbitos por causas semelhantes sem diagnóstico.

  16. CMB anisotropies at all orders: the non-linear Sachs-Wolfe formula

    OpenAIRE

    Roldan, Omar

    2017-01-01

    We obtain the non-linear generalization of the Sachs-Wolfe + integrated Sachs-Wolfe (ISW) formula describing the CMB temperature anisotropies. Our formula is valid at all orders in perturbation theory, is also valid in all gauges and includes scalar, vector and tensor modes. A direct consequence of our results is that the maps of the logarithmic temperature anisotropies are much cleaner than the usual CMB maps, because they automatically remove many secondary anisotropies. This can for instan...

  17. Tay-Sach disease with "cherry-red spot"--first reported case in Malaysia.

    Science.gov (United States)

    Chan, L Y; Balasubramaniam, S; Sunder, R; Jamalia, R; Karunakar, T V N; Alagaratnam, J

    2011-12-01

    We present a rare case of Tay-Sachs disease with retinal 'cherry-red spots' in a 19-month-old Malay child. Molecular genetic studies confirmed the diagnosis. The case highlights that 'cherry-red spot' is a useful clinical clue in Tay-Sachs disease and several other lysosomal storage disorders. It serves as an ideal illustration of the eye as a window to inborn error of metabolism.

  18. Tay Sachs and Related Storage Diseases: Family Planning

    Science.gov (United States)

    Schneiderman, Gerald; And Others

    1978-01-01

    Based on interviews with 24 families, the article discusses family planning and the choices available to those families in which a child has previously died from Tay-Sachs or related lipid storage diseases. (IM)

  19. Segregation of Tay-Sachs and Sandhoff alleles in a non-Jewish family.

    OpenAIRE

    Lane, A B; Young, E; Jenkins, T

    1980-01-01

    A non-Jewish family is presented in which the genes for Tay-Sachs disease and Sandhoff disease are segregating. Individuals heterozygous for both alleles have low serum and white cell total hexosaminidase levels together with a proportion of heat-labile hexosaminidase A (HEX A) which falls in the normal range. The individuals would not be detected as carriers of Tay-Sachs disease or Sandhoff disease in a population screening program.

  20. Distribution of a pseudodeficiency allele among Tay-Sachs carriers

    Energy Technology Data Exchange (ETDEWEB)

    Tomczak, J.; Grebner, E.E. (Thomas Jefferson Univ., Philadelphia, PA (United States)); Boogen, C. (Univ. of Essen Medical School (Germany))

    1993-08-01

    Recently Triggs-Raine et al. (1992) identified a new mutation in the gene coding for the [alpha]-subunit of [beta]-hexosaminidase A (hex A), the enzyme whose deficiency causes Tay-Sachs disease. This mutation, a C[sub 739]-to-T transition in exon 7, results in an altered enzyme that is active (albeit at reduced levels) in cells but that has essentially no activity in serum. This so-called pseudodeficient allele was first detected in compound heterozygotes who also carried a Tay-Sachs disease allele and therefore had no detectable hex A in their serum but who were in good health. Carriers of this apparently benign mutation are generally indistinguishable from carriers of a lethal mutation by means of routine enzyme-based screening tests, because the product of the pseudodeficient allele is not detectable in serum and has decreased activity in cells. This suggests that some individuals who have been classified as Tay-Sachs carriers are actually carriers of the pseudodeficient allele and are not at risk to have a child affected with Tay-Sachs disease. The pseudodeficient allele may also be responsible for some inconclusive diagnoses, where leukocyte values fall below the normal range but are still above the carrier range. The fact that there are now two mutant alleles (the psuedodeficient and the adult) that are indistinguishable from the lethal infantile mutations by means of enzyme assay yet that are phenotypically very different and that together may account for as much as 12% of enzyme-defined carriers on the basis of the data here suggests that DNA analysis should be part of a comprehensive screening program. It will be particularly useful to identify the mutations in couples at risk, before they undergo prenatal diagnosis. DNA analysis will also resolve some inconclusive diagnoses.

  1. Fermat Potentials of Embedded Lensing, the Integrated Sachs-Wolfe Effect, and Weak-Lensing of CMB by Cosmic Voids

    Science.gov (United States)

    Chen, Bin; Kantowski, R.; Dai, X.

    2014-01-01

    We have developed an accurate gravitational lens theory for an inhomogeneity embedded in an otherwise homogeneous universe, which to the lowest order is applicable to any mass distribution. We derive the Fermat potential for a spherically symmetric lens embedded in a FLRW cosmology and use it to investigate the late-time integrated Sachs-Wolfe effect (ISW) caused by individual large scale inhomogeneities, in particular, cosmic voids. We present a simple analytical expression for the CMB temperature fluctuation across such a lens as the derivative of the lens Fermat potential. Our formalism is applicable to both linear and nonlinear density evolution scenarios, to arbitrarily large density contrasts, and to all open and closed background cosmologies. Our results are particularly useful for modeling ISW effects extracted through stacking large numbers of cosmic voids and clusters (that is, the aperture photometry method). For structures co-expanding with the background cosmology, i.e., for time-independent density contrasts, we find that the gravitational lensing time delay alone can produce fluctuations of the order of seen in recent observations by WMAP and Planck. We revisit the possibility of explaining the non-Gaussian cold spot on the south hemisphere via the Rees-Sciama effect of a large cosmic void using constraints obtained from the most recent void catalogs and our new void-lensing formalism, and compare it with other explanations such as a collapsing cosmic texture. We also study the remapping of primordial CMB anisotropies, the weak-lensing shear, and magnification caused by void lensing.

  2. Outcomes of arthroscopic "Remplissage": capsulotenodesis of the engaging large Hill-Sachs lesion

    Directory of Open Access Journals (Sweden)

    Mayo Lee

    2011-06-01

    Full Text Available Abstract Background A Hill-Sachs lesion of the humeral head after a shoulder dislocation is clinically insignificant in most cases. However, a sizable defect will engage with the anterior rim of the glenoid and cause instability even after anterior glenoid reconstruction. The purpose of this study was to evaluate the outcome of arthroscopic capsulotenodesis of the posterior capsule and infraspinatus tendon ("remplissage" to seal a large engaging Hill-Sachs lesion in an unstable shoulder. Methods This was a prospective follow-up study of patients who underwent arthroscopic surgery for recurrent shoulder instability with a large engaging Hill-Sachs lesion from 2007 to 2009. The clinical results were measured preoperatively and postoperatively with the Simple Shoulder test (SST and the Rowe score for instability. Results Eleven patients met the inclusion criteria of this study. The mean follow-up time was 30 months (range 24 to 35 months. At the last follow-up, significant improvement was observed in both scores with no recurrent dislocations. The mean SST improved from 6.6 to 11 (p Conclusions Arthroscopic remplissage for shoulder instability is an effective soft tissue technique to seal a large engaging Hill-Sachs lesion with respect to recurrence rate, range of motion and shoulder function.

  3. Segregation of Tay-Sachs and Sandhoff alleles in a non-Jewish family.

    Science.gov (United States)

    Lane, A B; Young, E; Jenkins, T

    1980-01-01

    A non-Jewish family is presented in which the genes for Tay-Sachs disease and Sandhoff disease are segregating. Individuals heterozygous for both alleles have low serum and white cell total hexosaminidase levels together with a proportion of heat-labile hexosaminidase A (HEX A) which falls in the normal range. The individuals would not be detected as carriers of Tay-Sachs disease or Sandhoff disease in a population screening program. PMID:7446530

  4. The frequency of Tay-Sachs disease causing mutations in the Brazilian Jewish population justifies a carrier screening program.

    Science.gov (United States)

    Rozenberg, R; Pereira, L da V

    2001-07-05

    Tay-Sachs disease is an autosomal recessive disease characterized by progressive neurologic degeneration, fatal in early childhood. In the Ashkenazi Jewish population the disease incidence is about 1 in every 3,500 newborns and the carrier frequency is 1 in every 29 individuals. Carrier screening programs for Tay-Sachs disease have reduced disease incidence by 90% in high-risk populations in several countries. The Brazilian Jewish population is estimated at 90,000 individuals. Currently, there is no screening program for Tay-Sachs disease in this population. To evaluate the importance of a Tay-Sachs disease carrier screening program in the Brazilian Jewish population by determining the frequency of heterozygotes and the acceptance of the program by the community. Laboratory of Molecular Genetics--Institute of Biosciences--Universidade de São Paulo. 581 senior students from selected Jewish high schools. Molecular analysis of Tay-Sachs disease causing mutations by PCR amplification of genomic DNA, followed by restriction enzyme digestion. Among 581 students that attended educational classes, 404 (70%) elected to be tested for Tay-Sachs disease mutations. Of these, approximately 65% were of Ashkenazi Jewish origin. Eight carriers were detected corresponding to a carrier frequency of 1 in every 33 individuals in the Ashkenazi Jewish fraction of the sample. The frequency of Tay-Sachs disease carriers among the Ashkenazi Jewish population of Brazil is similar to that of other countries where carrier screening programs have led to a significant decrease in disease incidence. Therefore, it is justifiable to implement a Tay-Sachs disease carrier screening program for the Brazilian Jewish population.

  5. The white matter of the human cerebrum: Part I The occipital lobe by Heinrich Sachs

    Science.gov (United States)

    Forkel, Stephanie J.; Mahmood, Sajedha; Vergani, Francesco; Catani, Marco

    2015-01-01

    This is the first complete translation of Heinrich Sachs' outstanding white matter atlas dedicated to the occipital lobe. This work is accompanied by a prologue by Prof Carl Wernicke who for many years was Sachs' mentor in Breslau and enthusiastically supported his work. PMID:25527430

  6. Three-dimensional computed tomography measurement accuracy of varying Hill-Sachs lesion size.

    Science.gov (United States)

    Ho, Anthony; Kurdziel, Michael D; Koueiter, Denise M; Wiater, J Michael

    2018-02-01

    The glenoid track concept has been proposed to correlate shoulder stability with bone loss. Accurate assessment of Hill-Sachs lesion size preoperatively may affect surgical planning and postoperative outcomes; however, no measurement method has been universally accepted. This study aimed to assess the accuracy and reliability of measuring Hill-Sachs lesion sizes using 3-dimensional (3D) computed tomography (CT). Nine polyurethane humerus bone substitutes were used to create Hill-Sachs lesions of varying sizes with a combination of lesion depth (shallow, intermediate, and deep) and width (small, medium, and large). Specimens were scanned with a clinical CT scanner for size measurements and a micro-CT scanner for measurement of true lesion size. Six evaluators repeated measurements twice in a 2-week interval. Scans were measured by use of 3D CT reconstructions for length, width, and Hill-Sachs interval and with use of 2D CT for depth. The interclass correlation coefficient evaluated interobserver and intraobserver variability and percentage error, and Student t-tests assessed measurement accuracy. Interclass correlation coefficient reliability demonstrated strong agreement for all variables measured (0.856-0.975). Percentage error between measured length and measured depth and the true measurement significantly varied with respect to both lesion depth (P = .003 and P = .005, respectively) and lesion size (P = .049 and P = .004, respectively). The 3D CT imaging is effective and reproducible in determining lesion size. Determination of Hill-Sachs interval width is also reliable when it is applied to the glenoid track concept. Measured values on 3D and 2-dimensional imaging using a conventional CT scanner may slightly underestimate true measurements. Copyright © 2017 Journal of Shoulder and Elbow Surgery Board of Trustees. Published by Elsevier Inc. All rights reserved.

  7. [Sandhoff's and Tay-Sachs disease--based on our own cases].

    Science.gov (United States)

    Kokot, Witold; Raczyńska, Krystyna; Krajka-Lauer, Jarosława; Iwaszkiewicz-Bilikiewicz, Barbara; Wierzba, Jolanta

    2004-01-01

    The authors described two infant with Sandhoff's and Tay-Sachs disease. Tay-Sachs disease is well-known inherited disease leading to an accumulation of gangliosides in the brain and retina. Sandhoffs disease (GM2 gangliosidosis type 0) was diagnosed in an infant, in whom a progressive neurological disorder and cherry-red foveal spots were developed. In addition, to the general clinical examination, indirect ophthalnoscopy, blood white cells enzymatic examination are used to make definitive diagnosis. In this cases, the early eye fundus examination allowed us to make the proper diagnosis. The fundus change is characterized by the "cherry-red spot" in the central area.

  8. The frequency of Tay-Sachs disease causing mutations in the Brazilian Jewish population justifies a carrier screening program

    Directory of Open Access Journals (Sweden)

    Roberto Rozenberg

    Full Text Available CONTEXT: Tay-Sachs disease is an autosomal recessive disease characterized by progressive neurologic degeneration, fatal in early childhood. In the Ashkenazi Jewish population the disease incidence is about 1 in every 3,500 newborns and the carrier frequency is 1 in every 29 individuals. Carrier screening programs for Tay-Sachs disease have reduced disease incidence by 90% in high-risk populations in several countries. The Brazilian Jewish population is estimated at 90,000 individuals. Currently, there is no screening program for Tay-Sachs disease in this population. OBJECTIVE: To evaluate the importance of a Tay-Sachs disease carrier screening program in the Brazilian Jewish population by determining the frequency of heterozygotes and the acceptance of the program by the community. SETTING: Laboratory of Molecular Genetics - Institute of Biosciences - Universidade de São Paulo. PARTICIPANTS: 581 senior students from selected Jewish high schools. PROCEDURE: Molecular analysis of Tay-Sachs disease causing mutations by PCR amplification of genomic DNA, followed by restriction enzyme digestion. RESULTS: Among 581 students that attended educational classes, 404 (70% elected to be tested for Tay-Sachs disease mutations. Of these, approximately 65% were of Ashkenazi Jewish origin. Eight carriers were detected corresponding to a carrier frequency of 1 in every 33 individuals in the Ashkenazi Jewish fraction of the sample. CONCLUSION: The frequency of Tay-Sachs disease carriers among the Ashkenazi Jewish population of Brazil is similar to that of other countries where carrier screening programs have led to a significant decrease in disease incidence. Therefore, it is justifiable to implement a Tay-Sachs disease carrier screening program for the Brazilian Jewish population.

  9. Embedded Lensing Time Delays, the Fermat Potential, and the Integrated Sachs-Wolfe Effect

    Science.gov (United States)

    Chen, Bin; Kantowski, Ronald; Dai, Xinyu

    2015-05-01

    We derive the Fermat potential for a spherically symmetric lens embedded in a Friedman-Lemaître-Robertson-Walker cosmology and use it to investigate the late-time integrated Sachs-Wolfe (ISW) effect, i.e., secondary temperature fluctuations in the cosmic microwave background (CMB) caused by individual large-scale clusters and voids. We present a simple analytical expression for the temperature fluctuation in the CMB across such a lens as a derivative of the lens’ Fermat potential. This formalism is applicable to both linear and nonlinear density evolution scenarios, to arbitrarily large density contrasts, and to all open and closed background cosmologies. It is much simpler to use and makes the same predictions as conventional approaches. In this approach the total temperature fluctuation can be split into a time-delay part and an evolutionary part. Both parts must be included for cosmic structures that evolve and both can be equally important. We present very simple ISW models for cosmic voids and galaxy clusters to illustrate the ease of use of our formalism. We use the Fermat potentials of simple cosmic void models to compare predicted ISW effects with those recently extracted from WMAP and Planck data by stacking large cosmic voids using the aperture photometry method. If voids in the local universe with large density contrasts are no longer evolving we find that the time delay contribution alone predicts values consistent with the measurements. However, we find that for voids still evolving linearly, the evolutionary contribution cancels a significant part of the time delay contribution and results in predicted signals that are much smaller than recently observed.

  10. A pseudodeficiency allele common in non-Jewish Tay-Sachs carriers: Implications for carrier screening

    Energy Technology Data Exchange (ETDEWEB)

    Triggs-Raine, B.L.; Akerman, B.R.; Gravel, R.A. (McGill Univ.-Montreal Children' s Hospital Research Institute, Montreal, Quebec (Canada)); Mules, E.H.; Thomas, G.H.; Dowling, C.E. (Johns Hopkins School of Medicine, Baltimore, MD (United States)); Kaback, M.M.; Lim-Steele, J.S.T. (Univ. of California, San Diego, CA (United States)); Natowicz, M.R. (Eunice Kennedy Shriver Center for Mental Retardation, Waltham, MA (United States)); Grebner, E.E. (Thomas Jefferson Univ., Philadelphia, PA (United States)); Navon, R.R. (Tel-Aviv Univ., Kfar-Sava (Israel)); Welch, J.P. (Dalhousie Univ., Halifax, Nova, Scotia (Canada)); Greenberg, C.R. (Univ. of Manitoba, Winnipeg (Canada))

    1992-10-01

    Deficiency of [beta]-hexosaminidase A (Hex A) activity typically results in Tay-Sachs disease. However, healthy subjects found to be deficient in Hex A activity (i.e., pseudodeficient) by means of in vitro biochemical tests have been described. The authors analyzed the HEXA gene of one pseudodeficient subject and identified both a C[sub 739]-to-T substitution that changes Arg[sub 247][yields]Trp on one allele and a previously identified Tay-Sachs disease mutation of the second allele. Six additional pseudodeficient subjects were found to have the C[sub 739]-to-T but for none of 36 Jewish enzyme-defined carries who did not have one of three known mutations common to this group. The C[sub 739]-to-T allele, together with a [open quotes]true[close quotes] Tay-Sachs disease allele, causes Hex A pseudodeficiency. Given both the large proportion of non-Jewish carriers with this allele and that standard biochemical screening cannot differentiate between heterozygotes for the C[sub 739]-to-T mutations and Tay-Sachs disease carriers, DNA testing for this mutation in at-risk couples is essential. This could prevent unnecessary or incorrect prenatal diagnoses. 40 refs., 3 figs., 4 tabs.

  11. The white matter of the human cerebrum: part I The occipital lobe by Heinrich Sachs.

    Science.gov (United States)

    Forkel, Stephanie J; Mahmood, Sajedha; Vergani, Francesco; Catani, Marco

    2015-01-01

    This is the first complete translation of Heinrich Sachs' outstanding white matter atlas dedicated to the occipital lobe. This work is accompanied by a prologue by Prof Carl Wernicke who for many years was Sachs' mentor in Breslau and enthusiastically supported his work. Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.

  12. Planck 2015 results: XXI. The integrated Sachs-Wolfe effect

    DEFF Research Database (Denmark)

    Ade, P. A R; Aghanim, N.; Arnaud, M.

    2016-01-01

    This paper presents a study of the integrated Sachs-Wolfe (ISW) effect from the Planck 2015 temperature and polarization data release. This secondary cosmic microwave background (CMB) anisotropy caused by the large-scale time-evolving gravitational potential is probed from different perspectives....

  13. CMB anisotropies at all orders: the non-linear Sachs-Wolfe formula

    International Nuclear Information System (INIS)

    Roldan, Omar

    2017-01-01

    We obtain the non-linear generalization of the Sachs-Wolfe + integrated Sachs-Wolfe (ISW) formula describing the CMB temperature anisotropies. Our formula is valid at all orders in perturbation theory, is also valid in all gauges and includes scalar, vector and tensor modes. A direct consequence of our results is that the maps of the logarithmic temperature anisotropies are much cleaner than the usual CMB maps, because they automatically remove many secondary anisotropies. This can for instance, facilitate the search for primordial non-Gaussianity in future works. It also disentangles the non-linear ISW from other effects. Finally, we provide a method which can iteratively be used to obtain the lensing solution at the desired order.

  14. CMB anisotropies at all orders: the non-linear Sachs-Wolfe formula

    Energy Technology Data Exchange (ETDEWEB)

    Roldan, Omar, E-mail: oaroldan@if.ufrj.br [Instituto de Física, Universidade Federal do Rio de Janeiro, 21941-972, Rio de Janeiro, RJ (Brazil)

    2017-08-01

    We obtain the non-linear generalization of the Sachs-Wolfe + integrated Sachs-Wolfe (ISW) formula describing the CMB temperature anisotropies. Our formula is valid at all orders in perturbation theory, is also valid in all gauges and includes scalar, vector and tensor modes. A direct consequence of our results is that the maps of the logarithmic temperature anisotropies are much cleaner than the usual CMB maps, because they automatically remove many secondary anisotropies. This can for instance, facilitate the search for primordial non-Gaussianity in future works. It also disentangles the non-linear ISW from other effects. Finally, we provide a method which can iteratively be used to obtain the lensing solution at the desired order.

  15. Lyso-GM2 ganglioside: a possible biomarker of Tay-Sachs disease and Sandhoff disease.

    Science.gov (United States)

    Kodama, Takashi; Togawa, Tadayasu; Tsukimura, Takahiro; Kawashima, Ikuo; Matsuoka, Kazuhiko; Kitakaze, Keisuke; Tsuji, Daisuke; Itoh, Kohji; Ishida, Yo-Ichi; Suzuki, Minoru; Suzuki, Toshihiro; Sakuraba, Hitoshi

    2011-01-01

    To find a new biomarker of Tay-Sachs disease and Sandhoff disease. The lyso-GM2 ganglioside (lyso-GM2) levels in the brain and plasma in Sandhoff mice were measured by means of high performance liquid chromatography and the effect of a modified hexosaminidase (Hex) B exhibiting Hex A-like activity was examined. Then, the lyso-GM2 concentrations in human plasma samples were determined. The lyso-GM2 levels in the brain and plasma in Sandhoff mice were apparently increased compared with those in wild-type mice, and they decreased on intracerebroventricular administration of the modified Hex B. The lyso-GM2 levels in plasma of patients with Tay-Sachs disease and Sandhoff disease were increased, and the increase in lyso-GM2 was associated with a decrease in Hex A activity. Lyso-GM2 is expected to be a potential biomarker of Tay-Sachs disease and Sandhoff disease.

  16. Tay Sachs disease: an autopsy case report.

    Science.gov (United States)

    Jadhav, Meenal Vitthal; Landge, Meenal P; Sawaimoon, Satyakam K; Harke, Arun B; Deshmukh, Sanjay D

    2005-10-01

    This report describes a case report of a postmortem performed on a 5-year old patient of Tay-Sachs disease, presenting with failure to thrive, muscular flaccidity, and cherry-red spots on macula on fundoscopy. There was no history of similarly affected sibling or any other family member. The diagnosis was confirmed by enzyme studies. At postmortem, there was no organomegaly. The brain, on microscopy, showed vacuolated swollen neurons.

  17. Lyso-GM2 ganglioside: a possible biomarker of Tay-Sachs disease and Sandhoff disease.

    Directory of Open Access Journals (Sweden)

    Takashi Kodama

    Full Text Available To find a new biomarker of Tay-Sachs disease and Sandhoff disease. The lyso-GM2 ganglioside (lyso-GM2 levels in the brain and plasma in Sandhoff mice were measured by means of high performance liquid chromatography and the effect of a modified hexosaminidase (Hex B exhibiting Hex A-like activity was examined. Then, the lyso-GM2 concentrations in human plasma samples were determined. The lyso-GM2 levels in the brain and plasma in Sandhoff mice were apparently increased compared with those in wild-type mice, and they decreased on intracerebroventricular administration of the modified Hex B. The lyso-GM2 levels in plasma of patients with Tay-Sachs disease and Sandhoff disease were increased, and the increase in lyso-GM2 was associated with a decrease in Hex A activity. Lyso-GM2 is expected to be a potential biomarker of Tay-Sachs disease and Sandhoff disease.

  18. Energy in the Kantowski–Sachs space-time using teleparallel ...

    Indian Academy of Sciences (India)

    Inflation is again considered to be one of the early phases of the Universe [10]. For testing gravitational energy–momentum tensor of the teleparallel theory in quasilocal approach and also in the. Hamiltonian structure of TEGR, it is intended to calculate the total energy of inflationary. Kantowski–Sachs-type Universe. Again ...

  19. Correlation of augmented startle reflex with brainstem electrophysiological responses in Tay-Sachs disease.

    Science.gov (United States)

    Nakamura, Sadao; Saito, Yoshiaki; Ishiyama, Akihiko; Sugai, Kenji; Iso, Takashi; Inagaki, Masumi; Sasaki, Masayuki

    2015-01-01

    To clarify the evolution of an augmented startle reflex in Tay-Sachs disease and compare the temporal relationship between this reflex and brainstem evoked potentials. Clinical and electrophysiological data from 3 patients with Tay-Sachs disease were retrospectively collected. The augmented startle reflex appeared between the age of 3 and 17 months and disappeared between the age of 4 and 6 years. Analysis of brainstem auditory evoked potentials revealed that poor segregation of peak I, but not peak III, coincided with the disappearance of the augmented startle reflex. A blink reflex with markedly high amplitude was observed in a patient with an augmented startle reflex. The correlation between the augmented startle reflex and the preservation of peak I but not peak III supports the theory that the superior olivary nucleus is dispensable for this reflex. The blink reflex with high amplitudes may represent augmented excitability of reticular formation at the pontine tegmentum in Tay-Sachs disease, where the pattern generators for the augmented startle and blink reflexes may functionally overlap. Copyright © 2014 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.

  20. Neurocognitive testing in late-onset Tay-Sachs disease: a pilot study.

    Science.gov (United States)

    Elstein, D; Doniger, G M; Simon, E; Korn-Lubetzki, I; Navon, R; Zimran, A

    2008-08-01

    To test neurocognitive function in patients with late-onset Tay-Sachs disease (LOTS) using a computerized system to assess whether cognition is a clinically relevant outcome measure of possible therapeutic intervention in LOTS. Ten adults with Tay-Sachs disease were administered at least one battery of the Mindstreams Neurotrax system for evaluation of cognitive function. Six sub-scores and a Global Cognitive Score (GCS) were tabulated. A disease specific severity score was also devised with six domains. Despite identical genotypes, all patients but the two oldest had > or = 3/6 sub-scores one standard deviation below normal mean (100); verbal and executive functions were most affected. The severity score measured other functions. Because of provocative findings on re-testing in patients exposed to miglustat, and despite the very small cohort, cognitive function may be an appropriate and clinically relevant outcome measure for future therapeutic interventions in LOTS.

  1. Tay-Sachs disease with conspicuous cranial computerized tomographic appearances

    International Nuclear Information System (INIS)

    Watanabe, Kishichiro; Mukawa, Akio; Muto, Kazuhiko; Nishikawa, Jiro; Takahashi, Shigeko.

    1985-01-01

    An autopsy case of a 3-year-old female infant with Tay-Sachs disease was presented. A cherry red spot in the fundus and a deficiency of N-acetyl-β-hexosaminidase A in the white blood cells were revealed soon after admission at the age of one year. Her parents and sister were found to be healthy carriers. The patient showed a typical clinical course with marked cranial swelling. In addition to the marked ballooning of neurons on light microscope, membranous cytoplasmic body (MCB) on electron microscope and abnormal accumulation of GM 2 ganglioside in the cerebral cortex by thin layer chromatography were confirmed in the autopsy specimens. In the late stage of her clinical course, the cranial computerized tomography (CT) demonstrated symmetric and deep-wavy hyperdense cerebral cortical zones, diffuse hypodensity and diminished volume of cerebral white matter, mild to moderate ventricular dilatation, and a small cerebellum and brainstem. These conspicuous appearances of the cranial CT seem to be characteristic of Tay-Sachs disease in the late stage, and they are derived from abnormal accumulation of GM 2 ganglioside in the cerebral cortex, and diffuse intense demyelination (dysmyelinating demyelination) of the cerebral white matter. (author)

  2. Choroidal Coloboma in a Case of Tay-Sachs Disease

    OpenAIRE

    Ahmed, Nasreen Raees; Tripathy, Koushik; Kumar, Vivek; Gogia, Varun

    2014-01-01

    Coloboma as an ocular finding has been documented in various syndromes. Here we have a case of infantile Tay-Sachs disease associated with unilateral choroidal coloboma. To the best of our knowledge, such an association has not been documented in the literature. Whether such an association is a matter of chance or signifies the involvement of ganglioside metabolism in ocular embryogenesis remains to be elucidated.

  3. Choroidal coloboma in a case of tay-sachs disease.

    Science.gov (United States)

    Ahmed, Nasreen Raees; Tripathy, Koushik; Kumar, Vivek; Gogia, Varun

    2014-01-01

    Coloboma as an ocular finding has been documented in various syndromes. Here we have a case of infantile Tay-Sachs disease associated with unilateral choroidal coloboma. To the best of our knowledge, such an association has not been documented in the literature. Whether such an association is a matter of chance or signifies the involvement of ganglioside metabolism in ocular embryogenesis remains to be elucidated.

  4. Tay-Sachs and Sandhoff diseases: enzymatic diagnosis in dried blood spots on filter paper: retrospective diagnoses in newborn-screening cards.

    Science.gov (United States)

    Chamoles, Néstor A; Blanco, Mariana; Gaggioli, Daniela; Casentini, Carina

    2002-04-01

    Tay-Sachs disease (TSD), Sandhoff disease (SD) and variants are caused by deficient activity of the lysosomal enzymes hexosaminidase A (HA) and total hexosaminidase (TH) (hexosaminidase A plus B), respectively. For diagnosis, these enzymes are usually measured in plasma or extracts of leukocytes. We describe methods for the assay of hexosaminidase A and total hexosaminidase activities in dried blood spots (DBSs) on filter paper. We studied 163 healthy controls, 9 Tay-Sachs patients, 4 Sandhoff patients, 18 obligate carriers and the newborn-screening cards from two patients with Tay-Sachs and one patient with Sandhoff disease. To tubes containing a 3-mm-diameter blood spot, we added elution liquid and substrate solution. After incubation at 37 degrees C, the amount of hydrolyzed product was compared with a calibrator to allow the quantification of enzyme activity. The described methodology is useful to distinguish patients with Tay-Sachs disease or Sandhoff disease from carriers and controls using samples that are sufficiently stable to be transported to the testing laboratory by mail. The diagnosis of both diseases from a newborn-screening card (NSC) was clearly demonstrated, even after storage for up to 38 months at room temperature. The newborn-screening card has been added to the biological materials that allow the identification of patients with Tay-Sachs disease and Sandhoff disease.

  5. Preconception risk assessment for thalassaemia, sickle cell disease, cystic fibrosis and Tay-Sachs disease.

    Science.gov (United States)

    Hussein, Norita; Weng, Stephen F; Kai, Joe; Kleijnen, Jos; Qureshi, Nadeem

    2018-03-14

    Globally, about five per cent of children are born with congenital or genetic disorders. The most common autosomal recessive conditions are thalassaemia, sickle cell disease, cystic fibrosis and Tay-Sachs disease, with higher carrier rates in specific patient populations. Identifying and counselling couples at genetic risk of the conditions before pregnancy enables them to make fully informed reproductive decisions, with some of these choices not being available if genetic counselling is only offered in an antenatal setting. This is an update of a previously published review. To assess the effectiveness of systematic preconception genetic risk assessment to improve reproductive outcomes in women and their partners who are identified as carriers of thalassaemia, sickle cell disease, cystic fibrosis and Tay-Sachs disease in healthcare settings when compared to usual care. We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group's Trials Registers. In addition, we searched for all relevant trials from 1970 (or the date at which the database was first available if after 1970) to date using electronic databases (MEDLINE, Embase, CINAHL, PsycINFO), clinical trial databases (National Institutes of Health, Clinical Trials Search portal of the World Health Organization, metaRegister of controlled clinical trials), and hand searching of key journals and conference abstract books from 1998 to date (European Journal of Human Genetics, Genetics in Medicine, Journal of Community Genetics). We also searched the reference lists of relevant articles, reviews and guidelines and also contacted subject experts in the field to request any unpublished or other published trials.Date of latest search of the registers: 20 June 2017.Date of latest search of all other sources: 16 November 2017. Any randomised or quasi-randomised controlled trials (published or unpublished) comparing reproductive outcomes of systematic preconception genetic risk assessment for thalassaemia, sickle

  6. İki Kardeşte Görülen Tay-Sachs Hastalığı

    OpenAIRE

    KÜÇÜKÖDÜK, Ş.

    2010-01-01

    In view of two cases of autosomal recessive Tay-Sachs disease which affected two siblings, genetic consultation has been once more emphasized. The clinical features of this entity has been reviewed under the information obtained from recent literature. Otozomal resesif geçiş gösteren ve iki kardeşide etkiliyen Tay-Sachs hastalığında, genetik danışmanın önemi bir kez daha vurgulandı. Bu hastalığın klinik özellikleri literatür bilgilerinin ışığı altında gözden geçirildi....

  7. Tay-Sachs disease: high gene frequency in a non-Jewish population.

    Science.gov (United States)

    Kelly, T E; Chase, G A; Kaback, M M; Kumor, K; McKusick, V A

    1975-01-01

    A non-Amish "Pennsylvania Dutch" semi-isolate was found to have a high frequency of Tay-Sachs gene. This high frequency could be ascribed to founder effect and may represent, in microcosm, how this mechanism could have produced the high gene frequency among Ashkenazi Jews. PMID:803011

  8. 78 FR 24447 - Goldman Sachs Trust, et al.; Notice of Application

    Science.gov (United States)

    2013-04-25

    ... SECURITIES AND EXCHANGE COMMISSION [Investment Company Act Release No. 30471; 812-14075] Goldman Sachs Trust, et al.; Notice of Application April 19, 2013. AGENCY: Securities and Exchange Commission..., or cause more than 10% of the acquired company's voting stock to be owned by investment companies and...

  9. Testing general relativity at cosmological scales: Implementation and parameter correlations

    International Nuclear Information System (INIS)

    Dossett, Jason N.; Ishak, Mustapha; Moldenhauer, Jacob

    2011-01-01

    The testing of general relativity at cosmological scales has become a possible and timely endeavor that is not only motivated by the pressing question of cosmic acceleration but also by the proposals of some extensions to general relativity that would manifest themselves at large scales of distance. We analyze here correlations between modified gravity growth parameters and some core cosmological parameters using the latest cosmological data sets including the refined Cosmic Evolution Survey 3D weak lensing. We provide the parametrized modified growth equations and their evolution. We implement known functional and binning approaches, and propose a new hybrid approach to evolve the modified gravity parameters in redshift (time) and scale. The hybrid parametrization combines a binned redshift dependence and a smooth evolution in scale avoiding a jump in the matter power spectrum. The formalism developed to test the consistency of current and future data with general relativity is implemented in a package that we make publicly available and call ISiTGR (Integrated Software in Testing General Relativity), an integrated set of modified modules for the publicly available packages CosmoMC and CAMB, including a modified version of the integrated Sachs-Wolfe-galaxy cross correlation module of Ho et al. and a new weak-lensing likelihood module for the refined Hubble Space Telescope Cosmic Evolution Survey weak gravitational lensing tomography data. We obtain parameter constraints and correlation coefficients finding that modified gravity parameters are significantly correlated with σ 8 and mildly correlated with Ω m , for all evolution methods. The degeneracies between σ 8 and modified gravity parameters are found to be substantial for the functional form and also for some specific bins in the hybrid and binned methods indicating that these degeneracies will need to be taken into consideration when using future high precision data.

  10. Updated tomographic analysis of the integrated Sachs-Wolfe effect and implications for dark energy

    Science.gov (United States)

    Stölzner, Benjamin; Cuoco, Alessandro; Lesgourgues, Julien; Bilicki, Maciej

    2018-03-01

    We derive updated constraints on the integrated Sachs-Wolfe (ISW) effect through cross-correlation of the cosmic microwave background with galaxy surveys. We improve with respect to similar previous analyses in several ways. First, we use the most recent versions of extragalactic object catalogs, SDSS DR12 photometric redshift (photo-z ) and 2MASS Photo-z data sets, as well as those employed earlier for ISW, SDSS QSO photo-z and NVSS samples. Second, we use for the first time the WISE × SuperCOSMOS catalog, which allows us to perform an all-sky analysis of the ISW up to z ˜0.4 . Third, thanks to the use of photo-z s , we separate each data set into different redshift bins, deriving the cross-correlation in each bin. This last step leads to a significant improvement in sensitivity. We remove cross-correlation between catalogs using masks which mutually exclude common regions of the sky. We use two methods to quantify the significance of the ISW effect. In the first one, we fix the cosmological model, derive linear galaxy biases of the catalogs, and then evaluate the significance of the ISW using a single parameter. In the second approach we perform a global fit of the ISW and of the galaxy biases varying the cosmological model. We find significances of the ISW in the range 4.7 - 5.0 σ thus reaching, for the first time in such an analysis, the threshold of 5 σ . Without the redshift tomography we find a significance of ˜4.0 σ , which shows the importance of the binning method. Finally we use the ISW data to infer constraints on the dark energy redshift evolution and equation of state. We find that the redshift range covered by the catalogs is still not optimal to derive strong constraints, although this goal will be likely reached using future datasets such as from Euclid, LSST, and SKA.

  11. Diagnosis and molecular characterization of non-classic forms of Tay-Sachs disease in Brazil.

    Science.gov (United States)

    Rozenberg, R; Kok, F; Burin, M G; Sá Miranda, M C; Vasques, C; Henriques-Souza, A M M; Giugliani, R; Vainzof, Mariz; Pereira, L V

    2006-06-01

    Molecular analysis of five Brazilian families, including eight patients presenting with nonclassic Tay-Sachs disease, was performed to identify frequent causative mutations and their correlation with clinical course. Three patients were affected by the B1 subacute variant and were shown to carry the R178H mutation (the DN allele), which is also common among Portuguese patients. Two of them were compound heterozygotes, whereas the third presented with the mutation in both alleles. Since Brazil was a Portuguese colony for over two centuries, common ancestry might be the probable explanation. The fourth patient presented with a juvenile phenotype and carries the R499H mutation, which has been reported only once worldwide and is associated with residual enzyme activity, responsible for a slower clinical course. The fifth family, of an Ashkenazi Jewish background, showed an extensive intrafamilial clinical variability among three affected sibs presenting with muscle atrophy, ataxia, and psychiatric symptoms. They were first diagnosed as having atypical spinal muscular atrophy and, subsequently, spinocerebellar ataxia, but, recently, the diagnosis of late-onset Tay-Sachs disease was confirmed based on reduced plasma hexosaminidase A activity and the G269S/InsTATC1278 genotype. It is therefore highly recommended to test patients with a similar clinical history for Tay-Sachs disease. In the same family, one first cousin committed suicide at the age of 24 years, presenting with a clinical phenotype that suggested an undiagnosed case and highlighting the effect of the intrafamilial clinical variability in delaying a prompt diagnosis. It is now recognized that his parents are, in fact, a carrier couple. Additionally, another relative had been previously identified as a heterozygote in a Tay-Sachs disease screening program, but the information was not shared among the family. Since this information might anticipate diagnosis and genetic counseling, it is advisable that

  12. Choroidal Coloboma in a Case of Tay-Sachs Disease

    Directory of Open Access Journals (Sweden)

    Nasreen Raees Ahmed

    2014-01-01

    Full Text Available Coloboma as an ocular finding has been documented in various syndromes. Here we have a case of infantile Tay-Sachs disease associated with unilateral choroidal coloboma. To the best of our knowledge, such an association has not been documented in the literature. Whether such an association is a matter of chance or signifies the involvement of ganglioside metabolism in ocular embryogenesis remains to be elucidated.

  13. Balancing anisotropic curvature with gauge fields in a class of shear-free cosmological models

    Science.gov (United States)

    Thorsrud, Mikjel

    2018-05-01

    We present a complete list of general relativistic shear-free solutions in a class of anisotropic, spatially homogeneous and orthogonal cosmological models containing a collection of n independent p-form gauge fields, where p\\in\\{0, 1, 2, 3\\} , in addition to standard ΛCDM matter fields modelled as perfect fluids. Here a (collection of) gauge field(s) balances anisotropic spatial curvature on the right-hand side of the shear propagation equation. The result is a class of solutions dynamically equivalent to standard FLRW cosmologies, with an effective curvature constant Keff that depends both on spatial curvature and the energy density of the gauge field(s). In the case of a single gauge field (n  =  1) we show that the only spacetimes that admit such solutions are the LRS Bianchi type III, Bianchi type VI0 and Kantowski–Sachs metric, which are dynamically equivalent to open (Keff0 ) FLRW models, respectively. With a collection of gauge fields (n  >  1) also Bianchi type II admits a shear-free solution (Keff>0 ). We identify the LRS Bianchi type III solution to be the unique shear-free solution with a gauge field Hamiltonian bounded from below in the entire class of models.

  14. Splice junction mutation in some Ashkenazi Jews with Tay-Sachs disease: Evidence against a single defect within this ethnic group

    International Nuclear Information System (INIS)

    Myerowitz, R.

    1988-01-01

    Tay-Sachs disease is an inherited disorder in which the α chain of the lysosomal enzyme β-N-acetylhexosaminidase A bears the mutation. Ashkenazi Jews are found to be carriers for a severe type of Tay-Sachs disease, the classic form, 10 times more frequently than the general population. Ashkenazi Jewish patients with classic Tay-Sachs disease have appeared to be clinically and biochemically identical, and the usual assumption has been that they harbor the same α-chain mutation. The author has isolated the α-chain gene from an Ashkenazi Jewish patient, GM2968, with classic Tay-Sachs disease and compared its nucleotide sequences with that of the normal α-chain gene in the promoter region, exon and splice junction regions, and polyadenylylation signal area. Only one difference was observed between these sequences. The alteration is presumed to be functionally significant and to result in aberrant mRNA splicing. Utilizing the polymerase chain reaction to amplify the region encompassing the mutation, the author developed an assay to screen patients and heterozygote carriers for this mutation. Surprisingly, in each of two Ashkenazi patients, only one α-chain allele harbored the splice junction mutation. Only one parent of each of these patients was positive for the defect. Another Ashkenazi patient did not bear this mutation at all nor did either of the subject's parents. The data are consistent with the presence of more than one mutation underlying the classic form of Tay-Sachs disease in the Ashkenazi Jewish population

  15. General exact solution for homogeneous time-dependent self-gravitating perfect fluids

    International Nuclear Information System (INIS)

    Gaete, P.; Hojman, R.

    1988-01-01

    A procedure to obtain the general exact solution of Einstein equations for a self-gravitating spherically-symmetric static perfect fluid obeying an arbitrary equation of state, is applied to time-dependent Kantowsky-Sachs line elements (with spherical, planar and hyperbolic symmetry). As in the static case, the solution is generated by an arbitrary function of the independent variable and its first derivative. To illustrate the results, the whole family of (plane-symmetric) solutions with a ''gamma-law'' equation of state is explicity obtained in terms of simple known functions. It is also shown that, while in the static plane-symmtric line elements, every metric is in one to one correspondence with a ''partner-metric'' (both originated from the same generatrix function), in this case every generatrix function univocally determines one metric. (author) [pt

  16. Splice junction mutation in some Ashkenazi Jews with Tay-Sachs disease: Evidence against a single defect within this ethnic group

    Energy Technology Data Exchange (ETDEWEB)

    Myerowitz, R. (National Institute of Diabetes, Digestive and Kidney Diseases, Bethesda, MD (USA))

    1988-06-01

    Tay-Sachs disease is an inherited disorder in which the {alpha} chain of the lysosomal enzyme {beta}-N-acetylhexosaminidase A bears the mutation. Ashkenazi Jews are found to be carriers for a severe type of Tay-Sachs disease, the classic form, 10 times more frequently than the general population. Ashkenazi Jewish patients with classic Tay-Sachs disease have appeared to be clinically and biochemically identical, and the usual assumption has been that they harbor the same {alpha}-chain mutation. The author has isolated the {alpha}-chain gene from an Ashkenazi Jewish patient, GM2968, with classic Tay-Sachs disease and compared its nucleotide sequences with that of the normal {alpha}-chain gene in the promoter region, exon and splice junction regions, and polyadenylylation signal area. Only one difference was observed between these sequences. The alteration is presumed to be functionally significant and to result in aberrant mRNA splicing. Utilizing the polymerase chain reaction to amplify the region encompassing the mutation, the author developed an assay to screen patients and heterozygote carriers for this mutation. Surprisingly, in each of two Ashkenazi patients, only one {alpha}-chain allele harbored the splice junction mutation. Only one parent of each of these patients was positive for the defect. Another Ashkenazi patient did not bear this mutation at all nor did either of the subject's parents. The data are consistent with the presence of more than one mutation underlying the classic form of Tay-Sachs disease in the Ashkenazi Jewish population.

  17. Role of the physician in screening for carriers of Tay-Sachs disease.

    Science.gov (United States)

    Lowden, J. A.

    1978-01-01

    A screening test for carriers of Tay-Sachs disease has been available in Toronto for more than 6 years. In that time more than 11 000 Jewish residents have been tested. Most had requested testing after hearing about the screening program from friends or the media; few had been advised by their physicians to be tested. To sample the attitudes of physicians in Toronto towards carrier screening, we studied questionnaire responses of 42 physicians whose practices were composed largely of Jewish patients. Only 31% regularly advised their young adult Jewish patients to have a carrier screening test but 76% said they had patients who asked if they should be tested. Of the 14 (33%) who had had one or more patients with Tay-Sachs disease 6 did not advise carrier testing. There was a positive correlation between specialty training and support for the screening program. Methods for increasing physician advocacy of these programs are discussed. PMID:709448

  18. Planck CMB Anomalies: Astrophysical and Cosmological Secondary Effects and the Curse of Masking

    Science.gov (United States)

    Rassat, Anais

    2016-07-01

    Large-scale anomalies have been reported in CMB data with both WMAP and Planck data. These could be due to foreground residuals and or systematic effects, though their confirmation with Planck data suggests they are not due to a problem in the WMAP or Planck pipelines. If these anomalies are in fact primordial, then understanding their origin is fundamental to either validate the standard model of cosmology or to explore new physics. We investigate three other possible issues: 1) the trade-off between minimising systematics due to foreground contamination (with a conservative mask) and minimising systematics due to masking, 2) astrophysical secondary effects (the kinetic Doppler quadrupole and kinetic Sunyaev-Zel'dovich effect), and 3) secondary cosmological signals (the integrated Sachs-Wolfe effect). We address the masking issue by considering new procedures that use both WMAP and Planck to produce higher quality full-sky maps using the sparsity methodology (LGMCA maps). We show the impact of masking is dominant over that of residual foregrounds, and the LGMCA full-sky maps can be used without further processing to study anomalies. We consider four official Planck PR1 and two LGMCA CMB maps. Analysis of the observed CMB maps shows that only the low quadrupole and quadrupole-octopole alignment seem significant, but that the planar octopole, Axis of Evil, mirror parity and cold spot are not significant in nearly all maps considered. After subtraction of astrophysical and cosmological secondary effects, only the low quadrupole may still be considered anomalous, meaning the significance of only one anomaly is affected by secondary effect subtraction out of six anomalies considered. In the spirit of reproducible research all reconstructed maps and codes are available online.

  19. Black Hole Entropy from Bondi-Metzner-Sachs Symmetry at the Horizon.

    Science.gov (United States)

    Carlip, S

    2018-03-09

    Near the horizon, the obvious symmetries of a black hole spacetime-the horizon-preserving diffeomorphisms-are enhanced to a larger symmetry group with a three-dimensional Bondi-Metzner-Sachs algebra. Using dimensional reduction and covariant phase space techniques, I investigate this augmented symmetry and show that it is strong enough to determine the black hole entropy in any dimension.

  20. Cosmology

    International Nuclear Information System (INIS)

    Novikov, I.D.

    1979-01-01

    Progress made by this Commission over the period 1976-1978 is reviewed. Topics include the Hubble constant, deceleration parameter, large-scale distribution of matter in the universe, radio astronomy and cosmology, space astronomy and cosmology, formation of galaxies, physics near the cosmological singularity, and unconventional cosmological models. (C.F.)

  1. Rapid identification of HEXA mutations in Tay-Sachs patients.

    Science.gov (United States)

    Giraud, Carole; Dussau, Jeanne; Azouguene, Emilie; Feillet, François; Puech, Jean-Philippe; Caillaud, Catherine

    2010-02-19

    Tay-Sachs disease (TSD) is a recessively inherited neurodegenerative disorder due to mutations in the HEXA gene resulting in a beta-hexosaminidase A (Hex A) deficiency. The purpose of this study was to characterize the molecular abnormalities in patients with infantile or later-onset forms of the disease. The complete sequencing of the 14 exons and flanking regions of the HEXA gene was performed with a unique technical condition in 10 unrelated TSD patients. Eleven mutations were identified, including five splice mutations, one insertion, two deletions and three single-base substitutions. Four mutations were novel: two splice mutations (IVS8+5G>A, IVS2+4delAGTA), one missense mutation in exon 6 (c.621T>G (p.D207E)) and one small deletion (c.1211-1212delTG) in exon 11 resulting in a premature stop codon at residue 429. The c.621T>G missense mutation was found in a patient presenting an infantile form. Its putative role in the pathogenesis of TSD is suspected as residue 207 is highly conserved in human, mouse and rat. Moreover, structural modelling predicted changes likely to affect substrate binding and catalytic activity of the enzyme. The time-saving procedure reported here could be useful for the characterization of Tay-Sachs-causing mutations, in particular in non-Ashkenazi patients mainly exhibiting rare mutations. Copyright (c) 2010 Elsevier Inc. All rights reserved.

  2. Late-onset Tay-Sachs disease: adverse effects of medications and implications for treatment.

    Science.gov (United States)

    Shapiro, B E; Hatters-Friedman, S; Fernandes-Filho, J A; Anthony, K; Natowicz, M R

    2006-09-12

    The authors conducted a retrospective and brief prospective study of adverse effects of approximately 350 medications in 44 adults with late-onset Tay-Sachs disease (LOTS). Some medications were relatively safe, whereas others, particularly haloperidol, risperidone, and chlorpromazine, were associated with neurologic worsening.

  3. Scalar-tensor cosmology with cosmological constant

    International Nuclear Information System (INIS)

    Maslanka, K.

    1983-01-01

    The equations of scalar-tensor theory of gravitation with cosmological constant in the case of homogeneous and isotropic cosmological model can be reduced to dynamical system of three differential equations with unknown functions H=R/R, THETA=phi/phi, S=e/phi. When new variables are introduced the system becomes more symmetrical and cosmological solutions R(t), phi(t), e(t) are found. It is shown that when cosmological constant is introduced large class of solutions which depend also on Dicke-Brans parameter can be obtained. Investigations of these solutions give general limits for cosmological constant and mean density of matter in plane model. (author)

  4. Temporary Efficacy of Pyrimethamine in Juvenile-Onset Tay-Sachs Disease Caused by 2 Unreported HEXA Mutations in the Indian Population.

    Science.gov (United States)

    Udwadia-Hegde, Anaita; Hajirnis, Omkar

    2017-01-01

    Juvenile Tay-Sachs disease is rarer than other forms of Tay-Sachs disease and is usually seen in children between the age of 2 and 10 years. Pyrimethamine as a pharmacological chaperone was used to increase β-hexosaminidase A activity in this patient. We describe a patient with Tay-Sachs disease from the Indian population, a juvenile case who presented with developmental regression starting at the age of three, initially with motor followed by language regression. She is currently incapacitated with severe behavioral issues. This brief communication gives an insight into the efficacy of pharmacological chaperones. It also describes two unreported mutations in hexosaminidase A gene from the Indian population. After commencing Pyrimethamine, though initial benefits with increase in levels corresponded with briefly halting the motor regression, the observed increase was only transient and not associated with discernible beneficial neurological or psychiatric effects.

  5. Theoretical cosmology

    International Nuclear Information System (INIS)

    Raychaudhuri, A.K.

    1979-01-01

    The subject is covered in chapters, entitled; introduction; Newtonian gravitation and cosmology; general relativity and relativistic cosmology; analysis of observational data; relativistic models not obeying the cosmological principle; microwave radiation background; thermal history of the universe and nucleosynthesis; singularity of cosmological models; gravitational constant as a field variable; cosmological models based on Einstein-Cartan theory; cosmological singularity in two recent theories; fate of perturbations of isotropic universes; formation of galaxies; baryon symmetric cosmology; assorted topics (including extragalactic radio sources; Mach principle). (U.K.)

  6. Observable cosmology and cosmological models

    International Nuclear Information System (INIS)

    Kardashev, N.S.; Lukash, V.N.; Novikov, I.D.

    1987-01-01

    Modern state of observation cosmology is briefly discussed. Among other things, a problem, related to Hibble constant and slowdown constant determining is considered. Within ''pancake'' theory hot (neutrino) cosmological model explains well the large-scale structure of the Universe, but does not explain the galaxy formation. A cold cosmological model explains well light object formation, but contradicts data on large-scale structure

  7. Tay-Sachs disease: current perspectives from Australia

    Directory of Open Access Journals (Sweden)

    Lew RM

    2015-01-01

    Full Text Available Raelia M Lew,1,7 Leslie Burnett,2,3,4 Anné L Proos,2 Martin B Delatycki5,6 1Department of Obstetrics and Gynecology, QEII Research Institute for Mothers and Infants, The University of Sydney, Australia; 2NSW Health Pathology North, Royal North Shore Hospital, St Leonards, Australia; 3SEALS, Prince of Wales Hospital, Randwick, Australia; 4Sydney Medical School-Northern, Royal North Shore Hospital E25, University of Sydney, Sydney, Australia; 5Department of Clinical Genetics, Austin Health, Heidelberg, Australia; 6Bruce Lefroy Centre for Genetic Health Research, Murdoch Childrens Research Institute, Parkville, Australia; 7Department of Obstetrics and Gynaecology, Dentistry and Health Sciences, Faculty of Medicine, The University of Melbourne, Melbourne, Australia Abstract: Tay-Sachs disease (TSD is a fatal, recessively inherited neurodegenerative condition of infancy and early childhood. Although rare in most other populations, the carrier frequency is one in 25 in Ashkenazi Jews. Australian high-school-based TSD preconception genetic screening programs aim to screen, educate, and optimize reproductive choice for participants. These programs have demonstrated high uptake, low psychological morbidity, and have been shown to result in fewer than expected Jewish TSD-affected births over 18 years of operation. The majority of Jewish individuals of reproductive age outside of the high school screening program setting in Australia have not accessed screening. Recent recommendations advocate supplementing the community high school screening programs with general practitioner- and obstetrician-led genetic screening of Ashkenazi Jewish individuals for TSD and other severe recessive diseases for which this group is at risk. Massively parallel DNA sequencing is expected to become the testing modality of choice over the coming years. Keywords: Tay-Sachs disease, genetic screening, Australia

  8. Magnification-temperature correlation: The dark side of integrated Sachs-Wolfe measurements

    International Nuclear Information System (INIS)

    LoVerde, Marilena; Hui, Lam; Gaztanaga, Enrique

    2007-01-01

    Integrated Sachs-Wolfe (ISW) measurements, which involve cross-correlating the microwave background anisotropies with the foreground large-scale structure (e.g. traced by galaxies/quasars), have proven to be an interesting probe of dark energy. We show that magnification bias, which is the inevitable modulation of the foreground number counts by gravitational lensing, alters both the scale dependence and amplitude of the observed ISW signal. This is true especially at high redshifts because (1) the intrinsic galaxy-temperature signal diminishes greatly back in the matter-dominated era, (2) the lensing efficiency increases with redshift and (3) the number count slope generally steepens with redshift in a magnitude limited sample. At z > or approx. 2, the magnification-temperature correlation dominates over the intrinsic galaxy-temperature correlation and causes the observed ISW signal to increase with redshift, despite dark energy subdominance--a result of the fact that magnification probes structures all the way from the observer to the sources. Ignoring magnification bias therefore can lead to (significantly) erroneous conclusions about dark energy. While the lensing modulation opens up an interesting high z window for ISW measurements, high redshift measurements are not expected to add much new information to low redshift ones if dark energy is indeed the cosmological constant. This is because lensing introduces significant covariance across redshifts. The most compelling reasons for pursuing high redshift ISW measurements are to look for potential surprises such as early dark energy domination or signatures of modified gravity. We conclude with a discussion of existing measurements, the highest redshift of which is at the margin of being sensitive to the magnification effect. We also develop a formalism which might be of more general interest: to predict biases in estimating parameters when certain physical effects are ignored in interpreting observations

  9. Late-onset Tay-Sachs disease.

    Science.gov (United States)

    Barritt, Andrew W; Anderson, Stuart J; Leigh, P Nigel; Ridha, Basil H

    2017-10-01

    We discuss the assessment and differential diagnoses of a young adult Hungarian man with a 1-year history of a progressive and symmetric amyotrophic lateral sclerosis-like syndrome, along with irregular action tremor and stimulus-sensitive myoclonus of the arms. MR scan of the brain showed isolated cerebellar atrophy and formal neuropsychometric testing identified significant subclinical deficits in attention, processing speed and memory. We suspected a form of GM 2 gangliosidosis, and white cell enzyme analysis showed markedly reduced enzymatic activity of β-hexosaminidase A. Genetic testing subsequently revealed two heterozygous pathogenic mutations in the HEXA gene (c.1499delT p.(Leu500fs) and c.805G>A p.(Gly269Ser)), confirming the very rare diagnosis of adult-onset Tay-Sachs disease. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  10. Temporary Efficacy of Pyrimethamine in Juvenile-Onset Tay-Sachs Disease Caused by 2 Unreported HEXA Mutations in the Indian Population

    Directory of Open Access Journals (Sweden)

    Anaita Udwadia-Hegde MD, DCH, MRCPCH

    2017-01-01

    Full Text Available Background: Juvenile Tay-Sachs disease is rarer than other forms of Tay-Sachs disease and is usually seen in children between the age of 2 and 10 years. Pyrimethamine as a pharmacological chaperone was used to increase β-hexosaminidase A activity in this patient. Patient: We describe a patient with Tay-Sachs disease from the Indian population, a juvenile case who presented with developmental regression starting at the age of three, initially with motor followed by language regression. She is currently incapacitated with severe behavioral issues. Conclusion: This brief communication gives an insight into the efficacy of pharmacological chaperones. It also describes two unreported mutations in hexosaminidase A gene from the Indian population. After commencing Pyrimethamine, though initial benefits with increase in levels corresponded with briefly halting the motor regression, the observed increase was only transient and not associated with discernible beneficial neurological or psychiatric effects.

  11. Impact of gene patents and licensing practices on access to genetic testing and carrier screening for Tay-Sachs and Canavan disease.

    Science.gov (United States)

    Colaianni, Alessandra; Chandrasekharan, Subhashini; Cook-Deegan, Robert

    2010-04-01

    Genetic testing for Tay-Sachs and Canavan disease is particularly important for Ashkenazi Jews, because both conditions are more frequent in that population. This comparative case study was possible because of different patenting and licensing practices. The role of DNA testing differs between Tay-Sachs and Canavan diseases. The first-line screening test for Tay-Sachs remains an enzyme activity test rather than genotyping. Genotyping is used for preimplantation diagnosis and confirmatory testing. In contrast, DNA-based testing is the basis for Canavan screening and diagnosis. The HEXA gene for Tay-Sachs was cloned at the National Institutes of Health, and the gene was patented but has not been licensed. The ASPA gene for Canavan disease was cloned and patented by Miami Children's Hospital. Miami Children's Hospital did not inform family members and patient groups that had contributed to the gene discovery that it was applying for a patent, and pursued restrictive licensing practices when a patent issued in 1997. This led to intense controversy, litigation, and a sealed, nonpublic 2003 settlement that apparently allowed for nonexclusive licensing. A survey of laboratories revealed a possible price premium for ASPA testing, with per-unit costs higher than for other genetic tests in the Secretary's Advisory Committee on Genetics, Health, and Society case studies. The main conclusion from comparing genetic testing for Tay-Sachs and Canavan diseases, however, is that patenting and licensing conducted without communication with patients and advocates cause mistrust and can lead to controversy and litigation, a negative model to contrast with the positive model of patenting and licensing for genetic testing of cystic fibrosis.

  12. The effect of a combined glenoid and Hill-Sachs defect on glenohumeral stability: a biomechanical cadaveric study using 3-dimensional modeling of 142 patients.

    Science.gov (United States)

    Arciero, Robert A; Parrino, Anthony; Bernhardson, Andrew S; Diaz-Doran, Vilmaris; Obopilwe, Elifho; Cote, Mark P; Golijanin, Petr; Mazzocca, Augustus D; Provencher, Matthew T

    2015-06-01

    Bone loss in anterior glenohumeral instability occurs on both the glenoid and the humerus; however, existing biomechanical studies have evaluated glenoid and humeral head defects in isolation. Thus, little is known about the combined effect of these bony lesions in a clinically relevant model on glenohumeral stability. The purpose of this study was to determine the biomechanical efficacy of a Bankart repair in the setting of bipolar (glenoid and humeral head) bone defects determined via computer-generated 3-dimensional (3D) modeling of 142 patients with recurrent anterior shoulder instability. The null hypothesis was that adding a bipolar bone defect will have no effect on glenohumeral stability after soft tissue Bankart repair. Controlled laboratory study. A total of 142 consecutive patients with recurrent anterior instability were analyzed with 3D computed tomography scans. Two Hill-Sachs lesions were selected on the basis of volumetric size representing the 25th percentile (0.87 cm(3); small) and 50th percentile (1.47 cm(3); medium) and printed in plastic resin with a 3D printer. A total of 21 cadaveric shoulders were evaluated on a custom shoulder-testing device permitting 6 degrees of freedom, and the force required to translate the humeral head anteriorly 10 mm at a rate of 2.0 mm/s with a compressive load of 50 N was determined at 60° of glenohumeral abduction and 60° of external rotation. All Bankart lesions were made sharply from the 2- to 6-o'clock positions for a right shoulder. Subsequent Bankart repair with transosseous tunnels using high-strength suture was performed. Hill-Sachs lesions were made in the cadaver utilizing a plastic mold from the exact replica off the 3D printer. Testing was conducted in the following sequence for each specimen: (1) intact, (2) posterior capsulotomy, (3) Bankart lesion, (4) Bankart repair, (5) Bankart lesion with 2-mm glenoid defect, (6) Bankart repair, (7) Bankart lesion with 2-mm glenoid defect and Hill-Sachs lesion

  13. Planck CMB anomalies: astrophysical and cosmological secondary effects and the curse of masking

    International Nuclear Information System (INIS)

    Rassat, A.; Starck, J.-L.; Paykari, P.; Sureau, F.; Bobin, J.

    2014-01-01

    Large-scale anomalies have been reported in CMB data with both WMAP and Planck data. These could be due to foreground residuals and or systematic effects, though their confirmation with Planck data suggests they are not due to a problem in the WMAP or Planck pipelines. If these anomalies are in fact primordial, then understanding their origin is fundamental to either validate the standard model of cosmology or to explore new physics. We investigate three other possible issues: 1) the trade-off between minimising systematics due to foreground contamination (with a conservative mask) and minimising systematics due to masking, 2) astrophysical secondary effects (the kinetic Doppler quadrupole and kinetic Sunyaev-Zel'dovich effect), and 3) secondary cosmological signals (the integrated Sachs-Wolfe effect). We address the masking issue by considering new procedures that use both WMAP and Planck to produce higher quality full-sky maps using the sparsity methodology (LGMCA maps). We show the impact of masking is dominant over that of residual foregrounds, and the LGMCA full-sky maps can be used without further processing to study anomalies. We consider four official Planck PR1 and two LGMCA CMB maps. Analysis of the observed CMB maps shows that only the low quadrupole and quadrupole-octopole alignment seem significant, but that the planar octopole, Axis of Evil, mirror parity and cold spot are not significant in nearly all maps considered. After subtraction of astrophysical and cosmological secondary effects, only the low quadrupole may still be considered anomalous, meaning the significance of only one anomaly is affected by secondary effect subtraction out of six anomalies considered. In the spirit of reproducible research all reconstructed maps and codes will be made available for download here http://www.cosmostat.org/anomaliesCMB.html

  14. Planck CMB anomalies: astrophysical and cosmological secondary effects and the curse of masking

    Energy Technology Data Exchange (ETDEWEB)

    Rassat, A. [Laboratoire d' Astrophysique (LASTRO), École Polytechnique Fédérale de Lausanne (EPFL), 51 Chemin des Maillettes, Observatoire de Sauverny, Versoix, CH-1290 (Switzerland); Starck, J.-L.; Paykari, P.; Sureau, F.; Bobin, J., E-mail: anais.rassat@epfl.ch, E-mail: jstarck@cea.fr, E-mail: paniez.paykari@cea.fr, E-mail: florent.sureau@cea.fr, E-mail: jbobin@cea.fr [Laboratoire AIM, UMR CEA-CNRS-Paris, Irfu, SAp, CEA Saclay, Gif-Sur-Yvette Cedex, F-91191 France (France)

    2014-08-01

    Large-scale anomalies have been reported in CMB data with both WMAP and Planck data. These could be due to foreground residuals and or systematic effects, though their confirmation with Planck data suggests they are not due to a problem in the WMAP or Planck pipelines. If these anomalies are in fact primordial, then understanding their origin is fundamental to either validate the standard model of cosmology or to explore new physics. We investigate three other possible issues: 1) the trade-off between minimising systematics due to foreground contamination (with a conservative mask) and minimising systematics due to masking, 2) astrophysical secondary effects (the kinetic Doppler quadrupole and kinetic Sunyaev-Zel'dovich effect), and 3) secondary cosmological signals (the integrated Sachs-Wolfe effect). We address the masking issue by considering new procedures that use both WMAP and Planck to produce higher quality full-sky maps using the sparsity methodology (LGMCA maps). We show the impact of masking is dominant over that of residual foregrounds, and the LGMCA full-sky maps can be used without further processing to study anomalies. We consider four official Planck PR1 and two LGMCA CMB maps. Analysis of the observed CMB maps shows that only the low quadrupole and quadrupole-octopole alignment seem significant, but that the planar octopole, Axis of Evil, mirror parity and cold spot are not significant in nearly all maps considered. After subtraction of astrophysical and cosmological secondary effects, only the low quadrupole may still be considered anomalous, meaning the significance of only one anomaly is affected by secondary effect subtraction out of six anomalies considered. In the spirit of reproducible research all reconstructed maps and codes will be made available for download here http://www.cosmostat.org/anomaliesCMB.html.

  15. Expanding the spectrum of HEXA mutations in Indian patients with Tay-Sachs disease.

    Science.gov (United States)

    Sheth, Jayesh; Mistri, Mehul; Datar, Chaitanya; Kalane, Umesh; Patil, Shekhar; Kamate, Mahesh; Shah, Harshuti; Nampoothiri, Sheela; Gupta, Sarita; Sheth, Frenny

    2014-01-01

    Tay-Sachs disease is an autosomal recessive neurodegenerative disorder occurring due to impaired activity of β-hexosaminidase-A (EC 3.2.1.52), resulting from the mutation in HEXA gene. Very little is known about the molecular pathology of TSD in Indian children except for a few mutations identified by us. The present study is aimed to determine additional mutations leading to Tay-Sachs disease in nine patients confirmed by the deficiency of β-hexosaminidase-A (C (D175A) and c.805G>C (p.G269R) in one case; and one small 1 bp deletion c.426delT (p.F142LfsX57) and one splice site mutation c.459+4A>C in the other two cases respectively. None of these mutations were detected in 100 chromosomes from healthy individuals of the same ethnic group. Three previously reported missense mutations, (i) c.532C>T (p.R178C), (ii) c.964G>T (p.D322Y), and (iii) c.1385A>T (p.E462V); two nonsense mutations (i) c.709C>T (p.Q237X) and (ii) c.1528C>T (p.R510X), one 4 bp insertion c.1277_1278insTATC (p.Y427IfsX5) and one splice site mutation c.459+5G>A were also identified in six cases. We observe from this study that novel mutations are more frequently observed in Indian patients with Tay-Sachs disease with clustering of ~ 73% of disease causing mutations in exons 5 to 12. This database can be used for a carrier rate screening in the larger population of the country.

  16. Substrate reduction therapy in the infantile form of Tay-Sachs disease.

    Science.gov (United States)

    Bembi, B; Marchetti, F; Guerci, V I; Ciana, G; Addobbati, R; Grasso, D; Barone, R; Cariati, R; Fernandez-Guillen, L; Butters, T; Pittis, M G

    2006-01-24

    Substrate reduction therapy (SRT) with miglustat has been proposed for treatment of some lysosomal storage disorders. Based on the positive experience in Gaucher disease and experimental data in Tay-Sachs (TSD) and Sandhoff animal models, the authors investigated the clinical efficacy of SRT in two patients with infantile TSD. SRT could not arrest the patients' neurologic deterioration. However, a significant drug concentration in CSF as well as macrocephaly prevention were observed.

  17. Late onset Tay-Sachs disease in mice with targeted disruption of the Hexa gene: behavioral changes and pathology of the central nervous system.

    Science.gov (United States)

    Miklyaeva, Elena I; Dong, Weijia; Bureau, Alexandre; Fattahie, Roya; Xu, Yongqin; Su, Meng; Fick, Gordon H; Huang, Jing-Qi; Igdoura, Suleiman; Hanai, Nobuo; Gravel, Roy A

    2004-03-19

    Tay-Sachs disease is an autosomal recessive neurodegenerative disease resulting from a block in the hydrolysis of GM2 ganglioside, an intermediate in ganglioside catabolism. The mouse model of Tay-Sachs disease (Hexa -/-) has been described as behaviorally indistinguishable from wild type until at least 1 year of age due to a sialidase-mediated bypass of the metabolic defect that reduces the rate of GM2 ganglioside accumulation. In this study, we have followed our mouse model to over 2 years of age and have documented a significant disease phenotype that is reminiscent of the late onset, chronic form of human Tay-Sachs disease. Onset occurs at 11-12 months of age and progresses slowly, in parallel with increasing storage of GM2 ganglioside. The disease is characterized by hind limb spasticity, weight loss, tremors, abnormal posture with lordosis, possible visual impairment, and, late in the disease, muscle weakness, clasping of the limbs, and myoclonic twitches of the head. Immunodetection of GM2 ganglioside showed that storage varies widely in different regions, but is most intense in pyriform cortex, hippocampus (CA3 field, subiculum), amygdala, hypothalamus (paraventricular supraoptic, ventromedial and arcuate nuclei, and mammilary body), and the somatosensory cortex (layer V) in 1- to 2-year-old mutant mice. We suggest that the Tay-Sachs mouse model is a phenotypically valid model of disease and may provide for a reliable indicator of the impact of therapeutic strategies, in particular geared to the late onset, chronic form of human Tay-Sachs disease.

  18. Characterization of two Turkish beta-hexosaminidase mutations causing Tay-Sachs disease.

    Science.gov (United States)

    Ozkara, Hatice Asuman; Sandhoff, Konrad

    2003-04-01

    Two homoallelic mutations have recently been identified in the alpha-subunit of hexosaminidase A (EC 3.2.1.52) causing the infantile form of Tay-Sachs disease in Turkish patients. Both of these mutations, a 12 bp deletion (1096-1107 or 1098-1108 or 1099-1109) in exon 10 and a point mutation (G1362 to A, Gly454 to Asp) in exon 12, are located in the catalytic domain of the hexosaminidase alpha-chain. In order to determine whether these mutations affect the function of the catalytic domain or result in an instable protein, both mutant cDNAs were overexpressed in COS-1 cells. As judged by Western blotting, transfections of wild-type cDNA produced pro-alpha-chain and mature alpha-chain in parallel with a fivefold increase in cellular hexosaminidase activity using the synthetic substrate 4-methylumbelliferyl beta-N-acetylglucosamine 6-sulfate (MUGS). However, both mutants produced only pro-alpha-chains, although no mature form or detectable hexosaminidase activity towards two different synthetic substrates was observed. These data are consistent with the biochemical phenotype of infantile Tay-Sachs disease. We conclude that the overexpressed mutant pro-alpha-chains were misfolded and could not undergo further proteolytic processing to the active form of the enzyme in the lysosome.

  19. Precision Cosmology

    Science.gov (United States)

    Jones, Bernard J. T.

    2017-04-01

    Preface; Notation and conventions; Part I. 100 Years of Cosmology: 1. Emerging cosmology; 2. The cosmic expansion; 3. The cosmic microwave background; 4. Recent cosmology; Part II. Newtonian Cosmology: 5. Newtonian cosmology; 6. Dark energy cosmological models; 7. The early universe; 8. The inhomogeneous universe; 9. The inflationary universe; Part III. Relativistic Cosmology: 10. Minkowski space; 11. The energy momentum tensor; 12. General relativity; 13. Space-time geometry and calculus; 14. The Einstein field equations; 15. Solutions of the Einstein equations; 16. The Robertson-Walker solution; 17. Congruences, curvature and Raychaudhuri; 18. Observing and measuring the universe; Part IV. The Physics of Matter and Radiation: 19. Physics of the CMB radiation; 20. Recombination of the primeval plasma; 21. CMB polarisation; 22. CMB anisotropy; Part V. Precision Tools for Precision Cosmology: 23. Likelihood; 24. Frequentist hypothesis testing; 25. Statistical inference: Bayesian; 26. CMB data processing; 27. Parametrising the universe; 28. Precision cosmology; 29. Epilogue; Appendix A. SI, CGS and Planck units; Appendix B. Magnitudes and distances; Appendix C. Representing vectors and tensors; Appendix D. The electromagnetic field; Appendix E. Statistical distributions; Appendix F. Functions on a sphere; Appendix G. Acknowledgements; References; Index.

  20. Expanding the spectrum of HEXA mutations in Indian patients with Tay–Sachs disease

    Directory of Open Access Journals (Sweden)

    Jayesh Sheth

    2014-01-01

    Full Text Available Tay–Sachs disease is an autosomal recessive neurodegenerative disorder occurring due to impaired activity of β-hexosaminidase-A (EC 3.2.1.52, resulting from the mutation in HEXA gene. Very little is known about the molecular pathology of TSD in Indian children except for a few mutations identified by us. The present study is aimed to determine additional mutations leading to Tay–Sachs disease in nine patients confirmed by the deficiency of β-hexosaminidase-A (C (D175A and c.805G>C (p.G269R in one case; and one small 1 bp deletion c.426delT (p.F142LfsX57 and one splice site mutation c.459+4A>C in the other two cases respectively. None of these mutations were detected in 100 chromosomes from healthy individuals of the same ethnic group. Three previously reported missense mutations, (i c.532C>T (p.R178C, (ii c.964G>T (p.D322Y, and (iii c.1385A>T (p.E462V; two nonsense mutations (i c.709C>T (p.Q237X and (ii c.1528C>T (p.R510X, one 4 bp insertion c.1277_1278insTATC (p.Y427IfsX5 and one splice site mutation c.459+5G>A were also identified in six cases. We observe from this study that novel mutations are more frequently observed in Indian patients with Tay–Sachs disease with clustering of ~73% of disease causing mutations in exons 5 to 12. This database can be used for a carrier rate screening in the larger population of the country.

  1. Cosmology

    International Nuclear Information System (INIS)

    Contopoulos, G.; Kotsakis, D.

    1987-01-01

    An extensive first part on a wealth of observational results relevant to cosmology lays the foundation for the second and central part of the book; the chapters on general relativity, the various cosmological theories, and the early universe. The authors present in a complete and almost non-mathematical way the ideas and theoretical concepts of modern cosmology including the exciting impact of high-energy particle physics, e.g. in the concept of the ''inflationary universe''. The final part addresses the deeper implications of cosmology, the arrow of time, the universality of physical laws, inflation and causality, and the anthropic principle

  2. ACOG committee opinion. Number 318, October 2005. Screening for Tay-Sachs disease.

    Science.gov (United States)

    2005-10-01

    Tay-Sachs disease (TSD) is a severe progressive neurologic disease that causes death in early childhood. Carrier screening, should be offered before pregnancy to individuals and couples at high-risk, including those of Ashkenazi Jewish, French-Canadian, or Cajun descent and those with a family history consistent with TSD. If both partners are determined to be carriers of TSD, genetic counseling and prenatal diagnosis should be offered.

  3. Smoot Group Cosmology

    Science.gov (United States)

    the Universe About Cosmology Planck Satellite Launched Cosmology Videos Professor George Smoot's group conducts research on the early universe (cosmology) using the Cosmic Microwave Background radiation (CMB science goals regarding cosmology. George Smoot named Director of Korean Cosmology Institute The GRB

  4. Mathematical cosmology

    International Nuclear Information System (INIS)

    Wainwright, J.

    1990-01-01

    The workshop on mathematical cosmology was devoted to four topics of current interest. This report contains a brief discussion of the historical background of each topic and a concise summary of the content of each talk. The topics were; the observational cosmology program, the cosmological perturbation program, isotropic singularities, and the evolution of Bianchi cosmologies. (author)

  5. Modern Cosmology

    CERN Document Server

    Zhang Yuan Zhong

    2002-01-01

    This book is one of a series in the areas of high-energy physics, cosmology and gravitation published by the Institute of Physics. It includes courses given at a doctoral school on 'Relativistic Cosmology: Theory and Observation' held in Spring 2000 at the Centre for Scientific Culture 'Alessandro Volta', Italy, sponsored by SIGRAV-Societa Italiana di Relativita e Gravitazione (Italian Society of Relativity and Gravitation) and the University of Insubria. This book collects 15 review reports given by a number of outstanding scientists. They touch upon the main aspects of modern cosmology from observational matters to theoretical models, such as cosmological models, the early universe, dark matter and dark energy, modern observational cosmology, cosmic microwave background, gravitational lensing, and numerical simulations in cosmology. In particular, the introduction to the basics of cosmology includes the basic equations, covariant and tetrad descriptions, Friedmann models, observation and horizons, etc. The ...

  6. Doença de Tay-Sachs em criança de raça negra Tay-Sachs disease in a Negro child

    Directory of Open Access Journals (Sweden)

    Sérgio Rosemberg

    1970-12-01

    Full Text Available É relatado um caso de doença de Tay-Sachs em criança da raça negra. O encontro desta entidade em indivíduos não judeus é bastante raro, sendo este o quinto caso descrito em criança negra. Os autores estudam alguns aspectos genéticos, chegando à conclusão de que o cálculo da freqüência do gene mutante é impossível devido ao pequeno número de casos e ao fato de que não há estimativas seguras quanto à taxa de nascimento de indivíduos negros na população, Em que pese o fato de o diagnóstico se assentar em bases puramente clínicas e anatômicas, prescindindo os autores de exames bioquímicos específicos, os dados apresentados são congruentes com os casos clássicos descritos na literatura.A case of Tay-Sachs diseases in a Negro child is reported. The occurrence of this disease in non-Jewish individuals is very rare and this is the fifth case of a Negro-child reported in the litterature. Some genetical aspects are studied and the authors conclude that the frequency calculation of the mutant gene is impossible due to the small number of cases and to the fact that there is reliable information regarding the rate of birth of Negro individuals in the general population. The diagnosis was based on ophtalmological and clinical data. No specific biochemical tests were performed but the data obtained are congruent with other cases reported in the litterature.

  7. Unilaterally and rapidly progressing white matter lesion and elevated cytokines in a patient with Tay-Sachs disease.

    Science.gov (United States)

    Hayase, Tomomi; Shimizu, Jun; Goto, Tamako; Nozaki, Yasuyuki; Mori, Masato; Takahashi, Naoto; Namba, Eiji; Yamagata, Takanori; Momoi, Mariko Y

    2010-03-01

    We report the case of a girl with Tay-Sachs disease who had convulsions and deteriorated rapidly after an upper respiratory infection at the age of 11 months. At the age of 16 months, her seizures became intractable and magnetic resonance imaging of the brain showed high signal intensity on T2-weighted images and marked swelling in the white matter and basal nucelei of the right hemisphere. Her seizures and right hemisphere lesion improved with glycerol and dexamethasone treatment. When dexamethasone was discontinued, her symptoms worsened and lesions later appeared in the left hemisphere. Her cerebrospinal fluid showed elevated levels of the cytokines TNF-alpha and IL-5. It is considered that inflammation contributes to disease progression in Tay-Sachs disease.

  8. Neuro-ophthalmology of late-onset Tay-Sachs disease (LOTS).

    Science.gov (United States)

    Rucker, J C; Shapiro, B E; Han, Y H; Kumar, A N; Garbutt, S; Keller, E L; Leigh, R J

    2004-11-23

    Late-onset Tay-Sachs disease (LOTS) is an adult-onset, autosomal recessive, progressive variant of GM2 gangliosidosis, characterized by involvement of the cerebellum and anterior horn cells. To determine the range of visual and ocular motor abnormalities in LOTS, as a prelude to evaluating the effectiveness of novel therapies. Fourteen patients with biochemically confirmed LOTS (8 men; age range 24 to 53 years; disease duration 5 to 30 years) and 10 age-matched control subjects were studied. Snellen visual acuity, contrast sensitivity, color vision, stereopsis, and visual fields were measured, and optic fundi were photographed. Horizontal and vertical eye movements (search coil) were recorded, and saccades, pursuit, vestibulo-ocular reflex (VOR), vergence, and optokinetic (OK) responses were measured. All patients showed normal visual functions and optic fundi. The main eye movement abnormality concerned saccades, which were "multistep," consisting of a series of small saccades and larger movements that showed transient decelerations. Larger saccades ended earlier and more abruptly (greater peak deceleration) in LOTS patients than in control subjects; these changes can be attributed to premature termination of the saccadic pulse. Smooth-pursuit and slow-phase OK gains were reduced, but VOR, vergence, and gaze holding were normal. Patients with late-onset Tay-Sachs disease (LOTS) show characteristic abnormalities of saccades but normal afferent visual systems. Hypometria, transient decelerations, and premature termination of saccades suggest disruption of a "latch circuit" that normally inhibits pontine omnipause neurons, permitting burst neurons to discharge until the eye movement is completed. These measurable abnormalities of saccades provide a means to evaluate the effects of novel treatments for LOTS.

  9. String Gas Cosmology

    OpenAIRE

    Brandenberger, Robert H.

    2008-01-01

    String gas cosmology is a string theory-based approach to early universe cosmology which is based on making use of robust features of string theory such as the existence of new states and new symmetries. A first goal of string gas cosmology is to understand how string theory can effect the earliest moments of cosmology before the effective field theory approach which underlies standard and inflationary cosmology becomes valid. String gas cosmology may also provide an alternative to the curren...

  10. Atypical presentation of late-onset Tay-Sachs disease.

    Science.gov (United States)

    Deik, Andres; Saunders-Pullman, Rachel

    2014-05-01

    Late-onset Tay-Sachs disease (LOTS) is a lysosomal storage disease caused by deficient Beta-hexosaminidase A activity. We describe a 53-year-old woman who presented with adult-onset leg weakness, and whose initial diagnosis was progressive muscular atrophy without identifiable etiology. Development of cerebellar ataxia in mid-life prompted reassessment. Beta-hexosaminidase A quantification assay demonstrated absence of the isozyme. Genetic testing identified compound heterozygous mutations in the HEXA gene, confirming the diagnosis of LOTS. The phenotypic spectrum of LOTS includes motor neuronopathy, ataxia, choreoathetosis, neuropathy, and psychiatric symptoms in various combinations. This patient highlights the emergence of different clinical features over many years and emphasizes the need to consider LOTS in the differential diagnosis of progressive muscular atrophy. Copyright © 2013 Wiley Periodicals, Inc.

  11. Modern Cosmology

    Energy Technology Data Exchange (ETDEWEB)

    Zhang Yuanzhong

    2002-06-21

    This book is one of a series in the areas of high-energy physics, cosmology and gravitation published by the Institute of Physics. It includes courses given at a doctoral school on 'Relativistic Cosmology: Theory and Observation' held in Spring 2000 at the Centre for Scientific Culture 'Alessandro Volta', Italy, sponsored by SIGRAV-Societa Italiana di Relativita e Gravitazione (Italian Society of Relativity and Gravitation) and the University of Insubria. This book collects 15 review reports given by a number of outstanding scientists. They touch upon the main aspects of modern cosmology from observational matters to theoretical models, such as cosmological models, the early universe, dark matter and dark energy, modern observational cosmology, cosmic microwave background, gravitational lensing, and numerical simulations in cosmology. In particular, the introduction to the basics of cosmology includes the basic equations, covariant and tetrad descriptions, Friedmann models, observation and horizons, etc. The chapters on the early universe involve inflationary theories, particle physics in the early universe, and the creation of matter in the universe. The chapters on dark matter (DM) deal with experimental evidence of DM, neutrino oscillations, DM candidates in supersymmetry models and supergravity, structure formation in the universe, dark-matter search with innovative techniques, and dark energy (cosmological constant), etc. The chapters about structure in the universe consist of the basis for structure formation, quantifying large-scale structure, cosmic background fluctuation, galaxy space distribution, and the clustering of galaxies. In the field of modern observational cosmology, galaxy surveys and cluster surveys are given. The chapter on gravitational lensing describes the lens basics and models, galactic microlensing and galaxy clusters as lenses. The last chapter, 'Numerical simulations in cosmology', deals with spatial and

  12. Generalized Bondi-Sachs equations for characteristic formalism of numerical relativity

    Science.gov (United States)

    Cao, Zhoujian; He, Xiaokai

    2013-11-01

    The Cauchy formalism of numerical relativity has been successfully applied to simulate various dynamical spacetimes without any symmetry assumption. But discovering how to set a mathematically consistent and physically realistic boundary condition is still an open problem for Cauchy formalism. In addition, the numerical truncation error and finite region ambiguity affect the accuracy of gravitational wave form calculation. As to the finite region ambiguity issue, the characteristic extraction method helps much. But it does not solve all of the above issues. Besides the above problems for Cauchy formalism, the computational efficiency is another problem. Although characteristic formalism of numerical relativity suffers the difficulty from caustics in the inner near zone, it has advantages in relation to all of the issues listed above. Cauchy-characteristic matching (CCM) is a possible way to take advantage of characteristic formalism regarding these issues and treat the inner caustics at the same time. CCM has difficulty treating the gauge difference between the Cauchy part and the characteristic part. We propose generalized Bondi-Sachs equations for characteristic formalism for the Cauchy-characteristic matching end. Our proposal gives out a possible same numerical evolution scheme for both the Cauchy part and the characteristic part. And our generalized Bondi-Sachs equations have one adjustable gauge freedom which can be used to relate the gauge used in the Cauchy part. Then these equations can make the Cauchy part and the characteristic part share a consistent gauge condition. So our proposal gives a possible new starting point for Cauchy-characteristic matching.

  13. Dimensional cosmological principles

    International Nuclear Information System (INIS)

    Chi, L.K.

    1985-01-01

    The dimensional cosmological principles proposed by Wesson require that the density, pressure, and mass of cosmological models be functions of the dimensionless variables which are themselves combinations of the gravitational constant, the speed of light, and the spacetime coordinates. The space coordinate is not the comoving coordinate. In this paper, the dimensional cosmological principle and the dimensional perfect cosmological principle are reformulated by using the comoving coordinate. The dimensional perfect cosmological principle is further modified to allow the possibility that mass creation may occur. Self-similar spacetimes are found to be models obeying the new dimensional cosmological principle

  14. GM2-Gangliosidosis (Sandhoff and Tay Sachs disease): Diagnosis and Neuroimaging Findings (An Iranian Pediatric Case Series).

    Science.gov (United States)

    Karimzadeh, Parvaneh; Jafari, Narjes; Nejad Biglari, Habibeh; Jabbeh Dari, Sayena; Ahmad Abadi, Farzad; Alaee, Mohammad-Reza; Nemati, Hamid; Saket, Sasan; Tonekaboni, Seyed Hasan; Taghdiri, Mohammad-Mahdi; Ghofrani, Mohammad

    2014-01-01

    GM2-Gangliosidosis disease is a rare autosomal recessive genetic disorder that includes two disorders (Tay-Sachs and Sandhoff disease).These disorders cause a progressive deterioration of nerve cells and inherited deficiency in creating hexosaminidases A, B, and AB. Patients who were diagnosed withGM2-Gangliosidosis in the Neurology Department of Mofid Children's Hospital in Tehran, Iran from October 2009 to February 2014were included in our study. The disorder was confirmed by neurometabolic and enzyme level detection of hexosaminidases A, B, and AB in reference to Wagnester Laboratory in Germany. We assessed age, gender, past medical history, developmental status, clinical manifestations, and neuroimaging findings of 9 patients with Sandhoff disease and 9 with Tay Sachs disease. 83% of our patients were the offspring of consanguineous marriages. All of them had a developmental disorder as a chief complaint. 38%of patients had a history of developmental delay or regression and 22% had seizures. The patients with Sandhoff and Tay Sachs disease were followed for approximately 5 years and the follow-up showed all patients were bedridden or had expired due to refractory seizures, pneumonia aspiration, or swallowing disorders. Neuro-imaging findings included bilateral thalamic involvement, brain atrophy, and hypo myelination in near half of our patients (48%). According to the results of this study, we suggest that cherry-red spots, hyperacusis, refractory seizures, and relative parents in children with developmental delay and/or regression should be considered for assessment of GM2-Gangliosidosis disease.

  15. Targeted disruption of the Hexa gene results in mice with biochemical and pathologic features of Tay-Sachs disease

    Energy Technology Data Exchange (ETDEWEB)

    Proia, R.L.; Yamanaka, S.; Johnson, M.D. [and others

    1994-09-01

    Tay-Sachs disease, the prototype of the G{sub M2} gangliosidoses, is a catastrophic neurodegenerative disorder of infancy. The disease is caused by mutations in the HEXA gene resulting in an absence of the lysosomal enzyme, {beta}-hexosaminidase A. As consequence of the enzyme deficiency, G{sub M2} ganglioside accumulates progressively, beginning early in fetal life, to excessive amounts in the central nervous system (CNS). Rapid mental and motor deterioration starting in the first year of life leads to death by 2 to 4 years of age. Through the targeted disruption of the Hexa gene in embryonic stem cells, we have produced mice with biochemical and neuropathologic features of Tay-Sachs disease. The mutant mice exhibited less than 1% of normal {beta}-hexosaminidase A activity and accumulated G{sub M2} ganglioside in their CNS in an age-dependent manner. The accumulated ganglioside was stored in neurons as membranous cytoplasmic bodies characteristically found in the neurons of Tay-Sachs disease patients. At three to five months of age the mutant mice showed no apparent defects in motor or memory function. These {beta}-hexosaminidase A deficient mice should be useful for devising strategies to introduce functional enzymes and genes into the CNS. This model may also be valuable for studying the biochemical and pathologic changes occurring during the course of the disease.

  16. Shock absorption of below-knee prostheses : A comparison between the SACH and the Multiflex foot

    NARCIS (Netherlands)

    van Leeuwen, J. L.; Speth, L. A W M; Daanen, H. A M

    1990-01-01

    Shock waves were measured during walking on a treadmill on the metal tube of a below-knee KBM prosthesis, provided either with a SACH foot or with a Multiflex foot. Accelerations were measured in the axial direction and the dorso-ventral direction, about 160 mm proximal to the sole of the shoe. The

  17. Religion, theology and cosmology

    Directory of Open Access Journals (Sweden)

    John T. Fitzgerald

    2013-10-01

    Full Text Available Cosmology is one of the predominant research areas of the contemporary world. Advances in modern cosmology have prompted renewed interest in the intersections between religion, theology and cosmology. This article, which is intended as a brief introduction to the series of studies on theological cosmology in this journal, identifies three general areas of theological interest stemming from the modern scientific study of cosmology: contemporary theology and ethics; cosmology and world religions; and ancient cosmologies. These intersections raise important questions about the relationship of religion and cosmology, which has recently been addressed by William Scott Green and is the focus of the final portion of the article.

  18. An introduction to cosmology

    CERN Document Server

    Narlikar, Jayant Vishnu

    2002-01-01

    The third edition of this successful textbook is fully updated and includes important recent developments in cosmology. It begins with an introduction to cosmology and general relativity, and goes on to cover the mathematical models of standard cosmology. The physical aspects of cosmology, including primordial nucleosynthesis, the astroparticle physics of inflation, and the current ideas on structure formation are discussed. Alternative models of cosmology are reviewed, including the model of Quasi-Steady State Cosmology, which has recently been proposed as an alternative to Big Bang Cosmology.

  19. Molecular characterization of a novel HEXA mutation at the +3 position of intron 8 in a Tay-Sachs disease patient

    Energy Technology Data Exchange (ETDEWEB)

    Richard, M.; Triggs-Raine, B. [Univ. of Manitoba, Winnipeg (Canada); Natowicz, M. [E.K. Shriver Center, Waltham, MA (United States)

    1994-09-01

    Tay-Sachs disease is an autosomal recessive lysosomal storage disorder resulting from mutations in the HEXA gene that cause a deficiency in the activity of that enzyme {beta}-hexosaminidase A (Hex A). This deficiency leads to the build-up of G{sub M2} ganglioside, resulting in neurodegeneration and death. Biochemical analysis of a non-Jewish patient with a late-infantile form of Tay-Sachs disease revealed a substantial level of Hex A activity (38.4%) when 4-MUG was used as the substrate. However, when a substrate (4-MUGS) specific for the {alpha}-subunit of Hex A ({alpha}{beta}) was used, almost no activity was detected in the HEXA gene of the patient using SSCP analysis followed by sequencing. The first mutation, a G533A substitution in exon 5, is previously described and associated with the B1 form of Tay-Sachs disease. The second mutation is a novel a-to-g base change at the +3 position of intron 8. This was confirmed using the AIRS method, whereby a MaeIII site was created in the presence of the mutation. Normal and patient mRNA was reverse transcribed and exons 7 to 9 were PCR-amplified from the cDNA. An abnormally sized amplification product detected only in the patient cDNA was sequenced; exon 8 had been deleted and exons 7 and 9 were spliced together. A substantial level of normally-sized PCR product was also detected in the patient`s cDNA. Experiments are in progress to determine if this is produced from the allele harboring the G533A mutation. Given that previous mutations of this type have been associated with 97-100% abnormal splicing, this mutation is likely to be the cause, together with the G533A mutation, of Tay-Sachs disease in this patient.

  20. Mathematical cosmology

    International Nuclear Information System (INIS)

    Landsberg, P.T.; Evans, D.A.

    1977-01-01

    The subject is dealt with in chapters, entitled: cosmology -some fundamentals; Newtonian gravitation - some fundamentals; the cosmological differential equation - the particle model and the continuum model; some simple Friedmann models; the classification of the Friedmann models; the steady-state model; universe with pressure; optical effects of the expansion according to various theories of light; optical observations and cosmological models. (U.K.)

  1. Mechanism of interrupted saccades in patients with late-onset Tay-Sachs disease.

    Science.gov (United States)

    Optican, Lance M; Rucker, Janet C; Keller, Edward L; Leigh, R John

    2008-01-01

    In late-onset Tay-Sachs disease (LOTS), saccades are interrupted by one or more transient decelerations. Some saccades reaccelerate and continue on before eye velocity reaches zero, even in darkness. Intervals between successive decelerations are not regularly spaced. Peak decelerations of horizontal and vertical components of oblique saccades in LOTS is more synchronous than those in control subjects. We hypothesize that these decelerations are caused by dysregulation of the fastigial nuclei (FN) of the cerebellum, which fire brain stem inhibitory burst neurons (IBNs).

  2. Tay-Sachs disease: current perspectives from Australia.

    Science.gov (United States)

    Lew, Raelia M; Burnett, Leslie; Proos, Anné L; Delatycki, Martin B

    2015-01-01

    Tay-Sachs disease (TSD) is a fatal, recessively inherited neurodegenerative condition of infancy and early childhood. Although rare in most other populations, the carrier frequency is one in 25 in Ashkenazi Jews. Australian high-school-based TSD preconception genetic screening programs aim to screen, educate, and optimize reproductive choice for participants. These programs have demonstrated high uptake, low psychological morbidity, and have been shown to result in fewer than expected Jewish TSD-affected births over 18 years of operation. The majority of Jewish individuals of reproductive age outside of the high school screening program setting in Australia have not accessed screening. Recent recommendations advocate supplementing the community high school screening programs with general practitioner- and obstetrician-led genetic screening of Ashkenazi Jewish individuals for TSD and other severe recessive diseases for which this group is at risk. Massively parallel DNA sequencing is expected to become the testing modality of choice over the coming years.

  3. Introduction to cosmology

    CERN Document Server

    Roos, Matts

    2015-01-01

    The Fourth Edition of Introduction to Cosmology provides a concise, authoritative study of cosmology at an introductory level. Starting from elementary principles and the early history of cosmology, the text carefully guides the student on to curved spacetimes, special and general relativity, gravitational lensing, the thermal history of the Universe, and cosmological models, including extended gravity models, black holes and Hawking's recent conjectures on the not-so-black holes.

  4. On the cosmological gravitational waves and cosmological distances

    Science.gov (United States)

    Belinski, V. A.; Vereshchagin, G. V.

    2018-03-01

    We show that solitonic cosmological gravitational waves propagated through the Friedmann universe and generated by the inhomogeneities of the gravitational field near the Big Bang can be responsible for increase of cosmological distances.

  5. Cosmological principle

    International Nuclear Information System (INIS)

    Wesson, P.S.

    1979-01-01

    The Cosmological Principle states: the universe looks the same to all observers regardless of where they are located. To most astronomers today the Cosmological Principle means the universe looks the same to all observers because density of the galaxies is the same in all places. A new Cosmological Principle is proposed. It is called the Dimensional Cosmological Principle. It uses the properties of matter in the universe: density (rho), pressure (p), and mass (m) within some region of space of length (l). The laws of physics require incorporation of constants for gravity (G) and the speed of light (C). After combining the six parameters into dimensionless numbers, the best choices are: 8πGl 2 rho/c 2 , 8πGl 2 rho/c 4 , and 2 Gm/c 2 l (the Schwarzchild factor). The Dimensional Cosmological Principal came about because old ideas conflicted with the rapidly-growing body of observational evidence indicating that galaxies in the universe have a clumpy rather than uniform distribution

  6. Cosmology and particle physics

    International Nuclear Information System (INIS)

    Turner, M.S.

    1985-01-01

    The author reviews the standard cosmology, focusing on primordial nucleosynthesis, and discusses how the standard cosmology has been used to place constraints on the properties of various particles. Baryogenesis is examined in which the B, C, CP violating interactions in GUTs provide a dynamical explanation for the predominance of matter over antimatter and the present baryon-to-baryon ratio. Monoposes, cosmology and astrophysics are reviewed. The author also discusses supersymmetry/supergravity and cosmology, superstrings and cosmology in extra dimensions, and axions, astrophics, and cosmology

  7. Cosmology

    CERN Document Server

    Vittorio, Nicola

    2018-01-01

    Modern cosmology has changed significantly over the years, from the discovery to the precision measurement era. The data now available provide a wealth of information, mostly consistent with a model where dark matter and dark energy are in a rough proportion of 3:7. The time is right for a fresh new textbook which captures the state-of-the art in cosmology. Written by one of the world's leading cosmologists, this brand new, thoroughly class-tested textbook provides graduate and undergraduate students with coverage of the very latest developments and experimental results in the field. Prof. Nicola Vittorio shows what is meant by precision cosmology, from both theoretical and observational perspectives.

  8. Hill-Sachs lesion location: does it play a role in engagement?

    Energy Technology Data Exchange (ETDEWEB)

    Gyftopoulos, Soterios; Wang, Annie; Babb, James [NYU Langone Medical Center, Department of Radiology, New York, NY (United States)

    2015-08-15

    To see if there is an association between engagement on physical examination (PE) and the location of the Hill-Sachs lesion (HSL) as assessed by the modified biceps angle. Sixty-two patients with a history of anterior shoulder dislocation, who underwent preoperative MRI and arthroscopy at our institution and were tested for engagement on PE, were collected. Two musculoskeletal radiologists reviewed the MR studies, noting the presence of an HSL and documenting the location of the HSL with the modified biceps angle. Statistical analysis included the Mann-Whitney (MW) test and ROC (receiver-operating characteristic) curve. Of 62 patients, there were 58 males and 4 females with a mean age of 30 (range 18-59 years). Twenty patients demonstrated engagement on PE, while 42 did not. All patients had evidence of an HSL on MRI and arthroscopy. The mean biceps angle for the engaging group was 151.5 ± 13.9 , and 142.4 ± 17.3 for the non-engaging group. The biceps angle was statistically significantly higher among patients who had engagement compared to those who did not (p = 0.027). Overall, diagnostic accuracy was highest for a biceps angle >149 , which resulted in a sensitivity of 70 % and specificity of 67 %. The modified biceps angle, as measured on MRI, was significantly higher in patients who demonstrated engagement on physical examination than in those who did not. This supports the theory that the location of the Hill-Sachs lesion may play a role in engagement and may be its most important characteristic when determining its significance. (orig.)

  9. The Philosophy of Cosmology

    Science.gov (United States)

    Chamcham, Khalil; Silk, Joseph; Barrow, John D.; Saunders, Simon

    2017-04-01

    Part I. Issues in the Philosophy of Cosmology: 1. Cosmology, cosmologia and the testing of cosmological theories George F. R. Ellis; 2. Black holes, cosmology and the passage of time: three problems at the limits of science Bernard Carr; 3. Moving boundaries? - comments on the relationship between philosophy and cosmology Claus Beisbart; 4. On the question why there exists something rather than nothing Roderich Tumulka; Part II. Structures in the Universe and the Structure of Modern Cosmology: 5. Some generalities about generality John D. Barrow; 6. Emergent structures of effective field theories Jean-Philippe Uzan; 7. Cosmological structure formation Joel R. Primack; 8. Formation of galaxies Joseph Silk; Part III. Foundations of Cosmology: Gravity and the Quantum: 9. The observer strikes back James Hartle and Thomas Hertog; 10. Testing inflation Chris Smeenk; 11. Why Boltzmann brains do not fluctuate into existence from the de Sitter vacuum Kimberly K. Boddy, Sean M. Carroll and Jason Pollack; 12. Holographic inflation revised Tom Banks; 13. Progress and gravity: overcoming divisions between general relativity and particle physics and between physics and HPS J. Brian Pitts; Part IV. Quantum Foundations and Quantum Gravity: 14. Is time's arrow perspectival? Carlo Rovelli; 15. Relational quantum cosmology Francesca Vidotto; 16. Cosmological ontology and epistemology Don N. Page; 17. Quantum origin of cosmological structure and dynamical reduction theories Daniel Sudarsky; 18. Towards a novel approach to semi-classical gravity Ward Struyve; Part V. Methodological and Philosophical Issues: 19. Limits of time in cosmology Svend E. Rugh and Henrik Zinkernagel; 20. Self-locating priors and cosmological measures Cian Dorr and Frank Arntzenius; 21. On probability and cosmology: inference beyond data? Martin Sahlén; 22. Testing the multiverse: Bayes, fine-tuning and typicality Luke A. Barnes; 23. A new perspective on Einstein's philosophy of cosmology Cormac O

  10. Time variation of the cosmological redshift in Dicke-Brans-Jordan cosmologies

    International Nuclear Information System (INIS)

    Ruediger, R.

    1982-01-01

    In this paper the time variation z of the cosmological redshift z is discussed for Dicke-Brans-Jordan (DBJ) cosmologies. We determine the general z-z relation in the functional form zH -1 0 = F(z; q 0 , sigma 0 ,xi 0 , ω) for small values of z, where all the symbols have their conventional meanings. For certain combinations of cosmological parameters, which are within the present observational limitations, the DBJ terms in the function F can dominate the general relativistic terms. Furthermore, zH -1 0 can be positive in DBJ cosmologies in contrast to general relativistic cosmologies with q 0 >0

  11. Qualitative cosmology

    International Nuclear Information System (INIS)

    Khalatnikov, I.M.; Belinskij, V.A.

    1984-01-01

    Application of the qualitative theory of dynamic systems to analysis of homogeneous cosmological models is described. Together with the well-known cases, requiring ideal liquid, the properties of cosmological evolution of matter with dissipative processes due to viscosity are considered. New cosmological effects occur, when viscosity terms being one and the same order with the rest terms in the equations of gravitation or even exceeding them. In these cases the description of the dissipative process by means of only two viscosity coefficients (volume and shift) may become inapplicable because all the rest decomposition terms of dissipative addition to the energy-momentum in velocity gradient can be large application of equations with hydrodynamic viscosty should be considered as a model of dissipative effects in cosmology

  12. Introduction to cosmology

    CERN Document Server

    Roos, Matts

    2003-01-01

    The Third Edition of the hugely successful Introduction to Cosmology provides a concise, authoritative study of cosmology at an introductory level. Starting from elementary principles and the history of cosmology, the text carefully guides the student on to curved spacetimes, general relativity, black holes, cosmological models, particles and symmetries, and phase transitions. Extensively revised, this latest edition includes broader and updated coverage of distance measures, gravitational lensing and waves, dark energy and quintessence, the thermal history of the Universe, inflation,

  13. Higgs cosmology

    Science.gov (United States)

    Rajantie, Arttu

    2018-01-01

    The discovery of the Higgs boson in 2012 and other results from the Large Hadron Collider have confirmed the standard model of particle physics as the correct theory of elementary particles and their interactions up to energies of several TeV. Remarkably, the theory may even remain valid all the way to the Planck scale of quantum gravity, and therefore it provides a solid theoretical basis for describing the early Universe. Furthermore, the Higgs field itself has unique properties that may have allowed it to play a central role in the evolution of the Universe, from inflation to cosmological phase transitions and the origin of both baryonic and dark matter, and possibly to determine its ultimate fate through the electroweak vacuum instability. These connections between particle physics and cosmology have given rise to a new and growing field of Higgs cosmology, which promises to shed new light on some of the most puzzling questions about the Universe as new data from particle physics experiments and cosmological observations become available. This article is part of the Theo Murphy meeting issue `Higgs cosmology'.

  14. Smoot Cosmology Group

    Science.gov (United States)

    . ______________________________________________________________________________________ Nobelist George Smoot to Direct Korean Cosmology Institute Nobel Laureate George Smoot has been appointed director of a new cosmology institute in South Korea that will work closely with the year-old Berkeley the Early Universe (IEU) at EWHA Womans University in Seoul, Korea will provide cosmology education

  15. Serial MR imaging and 1H-MR spectroscopy in monozygotic twins with Tay-Sachs disease.

    Science.gov (United States)

    Imamura, A; Miyajima, H; Ito, R; Orii, K O

    2008-10-01

    Four-year-old monozygotic female twins with early onset Tay-Sachs disease are described. The sisters showed similar slowly progressive clinical symptoms and deterioration, however the younger sister also demonstrated intractable myoclonus in the right leg. The serial MR images and (1)H-MR spectroscopy of the brain were obtained in both twins. MR images showed high intensity on T (2)-weighted image in the bilateral white matter, however there were no signal changes in the basal ganglia and thalamus during any of the phases. The ratio of N-acetylaspartate (NAA)/creatine (Cr) was decreased in the both white matter lesions and the corpus striatum, and that of myoinositol (mI)/Cr was increased in the damaged white matter on MR spectroscopy. The elevation of the lactate peak was clearly demonstrated in the left basal ganglia of the younger sister; however it was not shown in cerebral lesions of the elder sister. Changes in metabolites on MR spectroscopy were closely linked to the respective clinical features of each twin. Follow-up examination by (1)H-MR spectroscopy is useful for the evaluation of neuronal changes in children with Tay-Sachs disease.

  16. Extending cosmology: the metric approach

    OpenAIRE

    Mendoza, S.

    2012-01-01

    Comment: 2012, Extending Cosmology: The Metric Approach, Open Questions in Cosmology; Review article for an Intech "Open questions in cosmology" book chapter (19 pages, 3 figures). Available from: http://www.intechopen.com/books/open-questions-in-cosmology/extending-cosmology-the-metric-approach

  17. Unimodular-mimetic cosmology

    International Nuclear Information System (INIS)

    Nojiri, S; Odintsov, S D; Oikonomou, V K

    2016-01-01

    We combine the unimodular gravity and mimetic gravity theories into a unified theoretical framework, which is proposed to provide a suggestive proposal for a framework that may assist in the discussion and search for a solution to the cosmological constant problem and the dark matter issue. After providing the formulation of the unimodular mimetic gravity and investigating all the new features that the vacuum unimodular gravity implies, by using the underlying reconstruction method, we realize some well known cosmological evolutions, with some of these being exotic for the ordinary Einstein–Hilbert gravity. Specifically we provide the vacuum unimodular mimetic gravity description of the de Sitter cosmology and of the perfect fluid with constant equation of state cosmology. As we demonstrate, these cosmologies can be realized by vacuum mimetic unimodular gravity, without the existence of any matter fluid source. Moreover, we investigate how cosmologically viable cosmologies, which are compatible with the recent observational data, can be realized by the vacuum unimodular mimetic gravity. Since in some cases, a graceful exit from inflation problem might exist, we provide a qualitative description of the mechanism that can potentially generate the graceful exit from inflation in these theories, by searching for the unstable de Sitter solutions in the context of unimodular mimetic theories of gravity. (paper)

  18. Cosmological constant problem

    International Nuclear Information System (INIS)

    Weinberg, S.

    1989-01-01

    Cosmological constant problem is discussed. History of the problem is briefly considered. Five different approaches to solution of the problem are described: supersymmetry, supergravity, superstring; anthropic approach; mechamism of lagrangian alignment; modification of gravitation theory and quantum cosmology. It is noted that approach, based on quantum cosmology is the most promising one

  19. Introduction to cosmology

    CERN Multimedia

    CERN. Geneva. Audiovisual Unit

    2001-01-01

    Cosmology and particle physics have enjoyed a useful relationship over the entire histories of both subjects. Today, ideas and techniques in cosmology are frequently used to elucidate and constrain theories of elementary particles. These lectures give an elementary overview of the essential elements of cosmology, which is necessary to understand this relationship.

  20. Introduction to cosmology

    CERN Multimedia

    CERN. Geneva

    1999-01-01

    Cosmology and particle physics have enjoyed a useful relationship over the entire histories of both subjects. Today, ideas and techniques in cosmology are frequently used to elucidate and constrain theories of elementary particles. These lectures give an elementary overview of the essential elements of cosmology, which is necessary to understand this relationship.

  1. The Dirac-Milne cosmology

    Science.gov (United States)

    Benoit-Lévy, Aurélien; Chardin, Gabriel

    2014-05-01

    We study an unconventional cosmology, in which we investigate the consequences that antigravity would pose to cosmology. We present the main characteristics of the Dirac-Milne Universe, a cosmological model where antimatter has a negative active gravitational mass. In this non-standard Universe, separate domains of matter and antimatter coexist at our epoch without annihilation, separated by a gravitationally induced depletion zone. We show that this cosmology does not require a priori the Dark Matter and Dark Energy components of the standard model of cosmology. Additionally, inflation becomes an unnecessary ingredient. Investigating this model, we show that the classical cosmological tests such as primordial nucleosynthesis, Type Ia supernovæ and Cosmic Microwave Background are surprisingly concordant.

  2. Implications of a decay law for the cosmological constant in higher dimensional cosmology and cosmological wormholes

    International Nuclear Information System (INIS)

    Rami, El-Nabulsi Ahmad

    2009-01-01

    Higher dimensional cosmological implications of a decay law for the cosmological constant term are analyzed. Three independent cosmological models are explored mainly: 1) In the first model, the effective cosmological constant was chosen to decay with times like Δ effective = Ca -2 + D(b/a I ) 2 where a I is an arbitrary scale factor characterizing the isotropic epoch which proceeds the graceful exit period. Further, the extra-dimensional scale factor decays classically like b(t) approx. a x (t), x is a real negative number. 2) In the second model, we adopt in addition to Δ effective = Ca -2 + D(b/a I ) 2 the phenomenological law b(t) = a(t)exp( -Qt) as we expect that at the origin of time, there is no distinction between the visible and extra dimensions; Q is a real number. 3) In the third model, we study a Δ - decaying extra-dimensional cosmology with a static traversable wormhole in which the four-dimensional Friedmann-Robertson-Walker spacetime is subject to the conventional perfect fluid while the extra-dimensional part is endowed by an exotic fluid violating strong energy condition and where the cosmological constant in (3+n+1) is assumed to decays like Δ(a) = 3Ca -2 . The three models are discussed and explored in some details where many interesting points are revealed. (author)

  3. BOOK REVIEW: Observational Cosmology Observational Cosmology

    Science.gov (United States)

    Howell, Dale Andrew

    2013-04-01

    Observational Cosmology by Stephen Serjeant fills a niche that was underserved in the textbook market: an up-to-date, thorough cosmology textbook focused on observations, aimed at advanced undergraduates. Not everything about the book is perfect - some subjects get short shrift, in some cases jargon dominates, and there are too few exercises. Still, on the whole, the book is a welcome addition. For decades, the classic textbooks of cosmology have focused on theory. But for every Sunyaev-Zel'dovich effect there is a Butcher-Oemler effect; there are as many cosmological phenomena established by observations, and only explained later by theory, as there were predicted by theory and confirmed by observations. In fact, in the last decade, there has been an explosion of new cosmological findings driven by observations. Some are so new that you won't find them mentioned in books just a few years old. So it is not just refreshing to see a book that reflects the new realities of cosmology, it is vital, if students are to truly stay up on a field that has widened in scope considerably. Observational Cosmology is filled with full-color images, and graphs from the latest experiments. How exciting it is that we live in an era where satellites and large experiments have gathered so much data to reveal astounding details about the origin of the universe and its evolution. To have all the latest data gathered together and explained in one book will be a revelation to students. In fact, at times it was to me. I've picked up modern cosmological knowledge through a patchwork of reading papers, going to colloquia, and serving on grant and telescope allocation panels. To go back and see them explained from square one, and summarized succinctly, filled in quite a few gaps in my own knowledge and corrected a few misconceptions I'd acquired along the way. To make room for all these graphs and observational details, a few things had to be left out. For one, there are few derivations

  4. Encyclopedia of cosmology historical, philosophical, and scientific foundations of modern cosmology

    CERN Document Server

    Hetherington, Norriss S

    2014-01-01

    The Encyclopedia of Cosmology, first published in 1993, recounts the history, philosophical assumptions, methodological ambiguities, and human struggles that have influenced the various responses to the basic questions of cosmology through the ages, as well as referencing important scientific theories.Just as the recognition of social conventions in other cultures can lead to a more productive perspective on our own behaviour, so too a study of the cosmologies of other times and places can enable us recognise elements of our own cosmology that might otherwise pass as inevitable developments.Ap

  5. Higgs cosmology.

    Science.gov (United States)

    Rajantie, Arttu

    2018-03-06

    The discovery of the Higgs boson in 2012 and other results from the Large Hadron Collider have confirmed the standard model of particle physics as the correct theory of elementary particles and their interactions up to energies of several TeV. Remarkably, the theory may even remain valid all the way to the Planck scale of quantum gravity, and therefore it provides a solid theoretical basis for describing the early Universe. Furthermore, the Higgs field itself has unique properties that may have allowed it to play a central role in the evolution of the Universe, from inflation to cosmological phase transitions and the origin of both baryonic and dark matter, and possibly to determine its ultimate fate through the electroweak vacuum instability. These connections between particle physics and cosmology have given rise to a new and growing field of Higgs cosmology, which promises to shed new light on some of the most puzzling questions about the Universe as new data from particle physics experiments and cosmological observations become available.This article is part of the Theo Murphy meeting issue 'Higgs cosmology'. © 2018 The Author(s).

  6. Neutrino cosmology

    CERN Document Server

    Lesgourgues, Julien; Miele, Gennaro; Pastor, Sergio

    2013-01-01

    The role that neutrinos have played in the evolution of the Universe is the focus of one of the most fascinating research areas that has stemmed from the interplay between cosmology, astrophysics and particle physics. In this self-contained book, the authors bring together all aspects of the role of neutrinos in cosmology, spanning from leptogenesis to primordial nucleosynthesis, their role in CMB and structure formation, to the problem of their direct detection. The book starts by guiding the reader through aspects of fundamental neutrino physics, such as the standard cosmological model and the statistical mechanics in the expanding Universe, before discussing the history of neutrinos in chronological order from the very early stages until today. This timely book will interest graduate students and researchers in astrophysics, cosmology and particle physics, who work with either a theoretical or experimental focus.

  7. Supernova cosmology

    International Nuclear Information System (INIS)

    Leibundgut, B.

    2005-01-01

    Supernovae have developed into a versatile tool for cosmology. Their impact on the cosmological model has been profound and led to the discovery of the accelerated expansion. The current status of the cosmological model as perceived through supernova observations will be presented. Supernovae are currently the only astrophysical objects that can measure the dynamics of the cosmic expansion during the past eight billion years. Ongoing experiments are trying to determine the characteristics of the accelerated expansion and give insight into what might be the physical explanation for the acceleration. (author)

  8. Supersymmetry and cosmology

    International Nuclear Information System (INIS)

    Feng, Jonathan L.

    2005-01-01

    Cosmology now provides unambiguous, quantitative evidence for new particle physics. I discuss the implications of cosmology for supersymmetry and vice versa. Topics include: motivations for supersymmetry; supersymmetry breaking; dark energy; freeze out and WIMPs; neutralino dark matter; cosmologically preferred regions of minimal supergravity; direct and indirect detection of neutralinos; the DAMA and HEAT signals; inflation and reheating; gravitino dark matter; Big Bang nucleosynthesis; and the cosmic microwave background. I conclude with speculations about the prospects for a microscopic description of the dark universe, stressing the necessity of diverse experiments on both sides of the particle physics/cosmology interface

  9. The inflationary cosmology

    International Nuclear Information System (INIS)

    Sasaki, Misao

    1983-01-01

    We review the recent status of the inflationary cosmology. After exhibiting the essence of difficulties associated with the horizon, flatness and baryon number problems in the standard big-bang cosmology, we discuss that the inflationary universe scenario is one of the most plausible solutions to these fundamental cosmological problems. Since there are two qualitatively different versions of the inflationary universe scenario, we review each of them separately and discuss merits and demerits of each version. The Hawking radiation in de Sitter space is also reviewed since it may play an essential role in the inflationary cosmology. (author)

  10. [Dr Mavro Sachs (1817-1888): the first lecturer of Zagreb University].

    Science.gov (United States)

    Dugacki, Vladimir

    2010-01-01

    Mavro Sachs (Jánosháza, Hungary, 1817 % emdash; Rijeka, 1888.) was a Zagreb student since 1828. In 1846 he graduated in medicine from the University of Vienna and returned to Zagreb to be the city physician. In 1849, he started to teach forensic medicine at the School of Law of the Royal Academy of Sciences in Zagreb and continued teaching the same subject at the Zagreb University Faculty of Law in the capacity of docent (corresponds to lecturer in the British system). He also taught medical law at pharmaceutical studies of Zagreb University. From 1855 to 1860, he presided over the Jewish Community of Zagreb.

  11. Cosmological evolution as squeezing: a toy model for group field cosmology

    Science.gov (United States)

    Adjei, Eugene; Gielen, Steffen; Wieland, Wolfgang

    2018-05-01

    We present a simple model of quantum cosmology based on the group field theory (GFT) approach to quantum gravity. The model is formulated on a subspace of the GFT Fock space for the quanta of geometry, with a fixed volume per quantum. In this Hilbert space, cosmological expansion corresponds to the generation of new quanta. Our main insight is that the evolution of a flat Friedmann–Lemaître–Robertson–Walker universe with a massless scalar field can be described on this Hilbert space as squeezing, familiar from quantum optics. As in GFT cosmology, we find that the three-volume satisfies an effective Friedmann equation similar to the one of loop quantum cosmology, connecting the classical contracting and expanding solutions by a quantum bounce. The only free parameter in the model is identified with Newton’s constant. We also comment on the possible topological interpretation of our squeezed states. This paper can serve as an introduction into the main ideas of GFT cosmology without requiring the full GFT formalism; our results can also motivate new developments in GFT and its cosmological application.

  12. Multimedia messages in genetics: design, development, and evaluation of a computer-based instructional resource for secondary school students in a Tay Sachs disease carrier screening program.

    Science.gov (United States)

    Gason, Alexandra A; Aitken, MaryAnne; Delatycki, Martin B; Sheffield, Edith; Metcalfe, Sylvia A

    2004-01-01

    Tay Sachs disease is a recessively inherited neurodegenerative disorder, for which carrier screening programs exist worldwide. Education for those offered a screening test is essential in facilitating informed decision-making. In Melbourne, Australia, we have designed, developed, and evaluated a computer-based instructional resource for use in the Tay Sachs disease carrier screening program for secondary school students attending Jewish schools. The resource entitled "Genetics in the Community: Tay Sachs disease" was designed on a platform of educational learning theory. The development of the resource included formative evaluation using qualitative data analysis supported by descriptive quantitative data. The final resource was evaluated within the screening program and compared with the standard oral presentation using a questionnaire. Knowledge outcomes were measured both before and after either of the educational formats. Data from the formative evaluation were used to refine the content and functionality of the final resource. The questionnaire evaluation of 302 students over two years showed the multimedia resource to be equally effective as an oral educational presentation in facilitating participants' knowledge construction. The resource offers a large number of potential benefits, which are not limited to the Tay Sachs disease carrier screening program setting, such as delivery of a consistent educational message, short delivery time, and minimum financial and resource commitment. This article outlines the value of considering educational theory and describes the process of multimedia development providing a framework that may be of value when designing genetics multimedia resources in general.

  13. Post-inflationary brane cosmology

    International Nuclear Information System (INIS)

    Mazumdar, Anupam

    2001-01-01

    The brane cosmology has invoked new challenges to the usual Big Bang cosmology. In this paper we present a brief account on thermal history of the post-inflationary brane cosmology. We have realized that it is not obvious that the post-inflationary brane cosmology would always deviate from the standard Big Bang cosmology. However, if it deviates some stringent conditions on the brane tension are to be satisfied. In this regard we study various implications on gravitino production and its abundance. We discuss Affleck-Dine mechanism for baryogenesis and make some comments on moduli and dilaton problems in this context

  14. Cosmology

    CERN Document Server

    García-Bellido, J

    2015-01-01

    In these lectures I review the present status of the so-called Standard Cosmological Model, based on the hot Big Bang Theory and the Inflationary Paradigm. I will make special emphasis on the recent developments in observational cosmology, mainly the acceleration of the universe, the precise measurements of the microwave background anisotropies, and the formation of structure like galaxies and clusters of galaxies from tiny primordial fluctuations generated during inflation.

  15. Regional neuro axonal injury detected by 1H 3 Tesla spectroscopic imaging in late onset Tay sachs

    International Nuclear Information System (INIS)

    Gagoski, Borjan Aleksandar; Eichler, Florian S.

    2010-01-01

    Late-onset Tay Sachs (LOTS) is a rare lysosomal storage disorder resulting from mutations of the subunit of the lysosomal enzyme β-hexosaminidase A, which catalyzes the degradation of GM2 ganglioside. We have applied the fast encoding spectroscopic imaging technique to LOTS patients to further investigate the neuro degenerative consequences of this disease.(Author)

  16. Einstein and cosmology

    International Nuclear Information System (INIS)

    Gekman, O.

    1982-01-01

    The brief essay of the development of the main ideas of relativistic cosmology is presented. The Einstein's cosmological work about the Universe - ''Cosmological considerations in connection with the general relativity theory'' - gave the basis to all further treatments in this field. In 1922 A. Friedman's work appeared, in which the first expanding Universe model was proposed as a solution of the Einstein field equations. The model was spherically closed, but its curvature radius was a function of time. About 1955 the searches for anisotropic homogeneous solutions to Einstein field equation began. It turned out that isotropic cosmological models are unstable in general. The predominant part of them transform to anisotropic at insignificant breaking of isotropy. The discovery of isotropic background cosmic radiation in 1965, along with the Hubble low of the Universe expansion, served as the direct confirmation of cosmology based on the Einstein theory

  17. Particle physics and cosmology

    International Nuclear Information System (INIS)

    Turner, M.S.; Schramm, D.N.

    1985-01-01

    During the past year, the research of the members of our group has spanned virtually all the topics at the interface of cosmology and particle physics: inflationary Universe scenarios, astrophysical and cosmological constraints on particle properties, ultra-high energy cosmic ray physics, quantum field theory in curved space-time, cosmology with extra dimensions, superstring cosmology, neutrino astronomy with large, underground detectors, and the formation of structure in the Universe

  18. Cosmology and time

    Directory of Open Access Journals (Sweden)

    Balbi Amedeo

    2013-09-01

    Full Text Available Time has always played a crucial role in cosmology. I review some of the aspects of the present cosmological model which are more directly related to time, such as: the definition of a cosmic time; the existence of typical timescales and epochs in an expanding universe; the problem of the initial singularity and the origin of time; the cosmological arrow of time.

  19. Quantum cosmology - science of Genesis

    International Nuclear Information System (INIS)

    Padmanabhan, Thanu

    1987-01-01

    Quantum cosmology, the marriage between the theories of the microscopic and macroscopic Universe, is examined in an attempt to explain the birth of the Universe in the 'big bang'. A quantum cosmological model of the Universe does not exist, but a rough approximation, or 'poor man's' version of quantum cosmology has been developed. The idea is to combine the theory of quantum mechanics with the classical cosmological solutions to obtain a quantum mechanical version of cosmology. Such a model of quantum cosmology is described -here the quantum universe behaves like a hydrogen atom with the Planck length replacing the Bohr radius. Properties of quantum cosmologies and the significance of the Planck length are both discussed. (UK)

  20. BMS in cosmology

    International Nuclear Information System (INIS)

    Kehagias, A.; Riotto, A.

    2016-01-01

    Symmetries play an interesting role in cosmology. They are useful in characterizing the cosmological perturbations generated during inflation and lead to consistency relations involving the soft limit of the statistical correlators of large-scale structure dark matter and galaxies overdensities. On the other hand, in observational cosmology the carriers of the information about these large-scale statistical distributions are light rays traveling on null geodesics. Motivated by this simple consideration, we study the structure of null infinity and the associated BMS symmetry in a cosmological setting. For decelerating Friedmann-Robertson-Walker backgrounds, for which future null infinity exists, we find that the BMS transformations which leaves the asymptotic metric invariant to leading order. Contrary to the asymptotic flat case, the BMS transformations in cosmology generate Goldstone modes corresponding to scalar, vector and tensor degrees of freedom which may exist at null infinity and perturb the asymptotic data. Therefore, BMS transformations generate physically inequivalent vacua as they populate the universe at null infinity with these physical degrees of freedom. We also discuss the gravitational memory effect when cosmological expansion is taken into account. In this case, there are extra contribution to the gravitational memory due to the tail of the retarded Green functions which are supported not only on the light-cone, but also in its interior. The gravitational memory effect can be understood also from an asymptotic point of view as a transition among cosmological BMS-related vacua.

  1. BMS in cosmology

    Energy Technology Data Exchange (ETDEWEB)

    Kehagias, A. [Physics Division, National Technical University of Athens, 15780 Zografou Campus, Athens (Greece); Riotto, A. [Department of Theoretical Physics,24 quai E. Ansermet, CH-1211 Geneva 4 (Switzerland); Center for Astroparticle Physics (CAP),24 quai E. Ansermet, CH-1211 Geneva 4 (Switzerland)

    2016-05-25

    Symmetries play an interesting role in cosmology. They are useful in characterizing the cosmological perturbations generated during inflation and lead to consistency relations involving the soft limit of the statistical correlators of large-scale structure dark matter and galaxies overdensities. On the other hand, in observational cosmology the carriers of the information about these large-scale statistical distributions are light rays traveling on null geodesics. Motivated by this simple consideration, we study the structure of null infinity and the associated BMS symmetry in a cosmological setting. For decelerating Friedmann-Robertson-Walker backgrounds, for which future null infinity exists, we find that the BMS transformations which leaves the asymptotic metric invariant to leading order. Contrary to the asymptotic flat case, the BMS transformations in cosmology generate Goldstone modes corresponding to scalar, vector and tensor degrees of freedom which may exist at null infinity and perturb the asymptotic data. Therefore, BMS transformations generate physically inequivalent vacua as they populate the universe at null infinity with these physical degrees of freedom. We also discuss the gravitational memory effect when cosmological expansion is taken into account. In this case, there are extra contribution to the gravitational memory due to the tail of the retarded Green functions which are supported not only on the light-cone, but also in its interior. The gravitational memory effect can be understood also from an asymptotic point of view as a transition among cosmological BMS-related vacua.

  2. Philosophical Roots of Cosmology

    Science.gov (United States)

    Ivanovic, M.

    2008-10-01

    We shall consider the philosophical roots of cosmology in the earlier Greek philosophy. Our goal is to answer the question: Are earlier Greek theories of pure philosophical-mythological character, as often philosophers cited it, or they have scientific character. On the bases of methodological criteria, we shall contend that the latter is the case. In order to answer the question about contemporary situation of the relation philosophy-cosmology, we shall consider the next question: Is contemporary cosmology completely independent of philosophical conjectures? The answer demands consideration of methodological character about scientific status of contemporary cosmology. We also consider some aspects of the relation contemporary philosophy-cosmology.

  3. Observational cosmology

    NARCIS (Netherlands)

    Sanders, RH; Papantonopoulos, E

    2005-01-01

    I discuss the classical cosmological tests, i.e., angular size-redshift, flux-redshift, and galaxy number counts, in the light of the cosmology prescribed by the interpretation of the CMB anisotropies. The discussion is somewhat of a primer for physicists, with emphasis upon the possible systematic

  4. Neutrino cosmology

    International Nuclear Information System (INIS)

    Berstein, J.

    1984-01-01

    These lectures offer a self-contained review of the role of neutrinos in cosmology. The first part deals with the question 'What is a neutrino.' and describes in a historical context the theoretical ideas and experimental discoveries related to the different types of neutrinos and their properties. The basic differences between the Dirac neutrino and the Majorana neutrino are pointed out and the evidence for different neutrino 'flavours', neutrino mass, and neutrino oscillations is discussed. The second part summarizes current views on cosmology, particularly as they are affected by recent theoretical and experimental advances in high-energy particle physics. Finally, the close relationship between neutrino physics and cosmology is brought out in more detail, to show how cosmological constraints can limit the various theoretical possibilities for neutrinos and, more particularly, how increasing knowledge of neutrino properties can contribute to our understanding of the origin, history, and future of the Universe. The level is that of the beginning graduate student. (orig.)

  5. Cosmology and particle physics

    International Nuclear Information System (INIS)

    Turner, M.S.

    1986-01-01

    Progress in cosmology has become linked to progress in elementary particle physics. In these six lectures, the author illustrates the two-way nature of the interplay between these fields by focusing on a few selected topics. In the next section the author reviews the standard cosmology, especially concentrating on primordial nucleosynthesis and discusses how the standard cosmology has been used to place constraints on the properties of various particles. Grand Unification makes two striking predictions: (i) B non-conservation; (ii) the existence of stable, superheavy magnetic monopoles. Both have had great cosmological impact. In the following section the author discusses baryogenesis, the very attractive scenario in which the B,C,CP violating interactions in GUTs provide a dynamical explanation for the predominance of matter over antimatter and the present baryon-to-photon ratio. Monopoles are a cosmological disaster and an astrophysicist's delight. In Section 4 discusses monopoles, cosmology, and astrophysics. In the fourth lecture the author discusses how a very early (t≤10/sup -34/ sec) phase transition associated with spontaneous symmetry breaking (SSB) has the potential to explain a handful of very fundamental cosmological facts, facts which can be accommodated by the standard cosmology, but which are not ''explained'' by it. The fifth lecture is devoted to a discussion of structure formation in the universe

  6. Tay-Sachs disease: progression of changes on neuroimaging in four cases

    International Nuclear Information System (INIS)

    Fukumizu, M.; Yoshikawa, H.; Kurokawa, T.; Takashima, S.; Sakuragawa, N.

    1992-01-01

    The neuroradiological findings in four patients with Tay-Sachs disease are described in three phases of the clinical course. The basal ganglia and cerebral white matter show low density on computed tomography and high signal intensity on T2-weighted magnetic resonance imaging in the initial phase. The caudate nuclei are characteristically enlarged and protrude into the lateral ventricles in the first and second phases. The cerebral white matter shows low density on the CT which varies in extent from the second to third phases, and the whole brain becomes atrophic in the last phase. Thus, central nervous system involvement in the disease may begin in basal ganglia as well as in cerebral white matter. (orig.)

  7. Tay-Sachs disease: progression of changes on neuroimaging in four cases

    Energy Technology Data Exchange (ETDEWEB)

    Fukumizu, M; Yoshikawa, H; Kurokawa, T [National Center Hospital for Mental, Nervous, and Muscular Disorders, Tokyo (Japan). Div. of Child Neurology; Takashima, S [National Inst. of Neuroscience, National Center of Neurology and Psychiatry, Tokyo (Japan). Div. of Mental Retardation and Birth Defect Research; Sakuragawa, N [National Inst. of Neuroscience, National Center of Neurology and Psychiatry, Tokyo (Japan). Div. of Inherited Metabolic Disease

    1992-11-01

    The neuroradiological findings in four patients with Tay-Sachs disease are described in three phases of the clinical course. The basal ganglia and cerebral white matter show low density on computed tomography and high signal intensity on T2-weighted magnetic resonance imaging in the initial phase. The caudate nuclei are characteristically enlarged and protrude into the lateral ventricles in the first and second phases. The cerebral white matter shows low density on the CT which varies in extent from the second to third phases, and the whole brain becomes atrophic in the last phase. Thus, central nervous system involvement in the disease may begin in basal ganglia as well as in cerebral white matter. (orig.).

  8. The cosmological perturbation theory in loop cosmology with holonomy corrections

    International Nuclear Information System (INIS)

    Wu, Jian-Pin; Ling, Yi

    2010-01-01

    In this paper we investigate the scalar mode of first-order metric perturbations over spatially flat FRW spacetime when the holonomy correction is taken into account in the semi-classical framework of loop quantum cosmology. By means of the Hamiltonian derivation, the cosmological perturbation equations is obtained in longitudinal gauge. It turns out that in the presence of metric perturbation the holonomy effects influence both background and perturbations, and contribute the non-trivial terms S h1 and S h2 in the cosmological perturbation equations

  9. A taste of cosmology

    International Nuclear Information System (INIS)

    Verde, L.

    2011-01-01

    This is the summary of two lectures that aim to give an overview of cosmology. I will not try to be toa rigorous in derivations, nor to give a full historical overview. The idea is to provide a 'taste' of cosmology and some of the interesting topics it covers. The standard cosmological model is presented and I highlight the successes of cosmology over the past decade or so. Keys to the development of the standard cosmological model are observations of the cosmic microwave background and of large-scale structure, which are introduced. Inflation and dark energy and the outlook for the future are also discussed. Slides from the lectures are available from the school web site: physicschool.web.cern.ch/PhysicSchool/CLASHEP/CLASHEP2011/. (author)

  10. A Taste of Cosmology

    CERN Document Server

    Verde, L.

    2013-06-27

    This is the summary of two lectures that aim to give an overview of cosmology. I will not try to be too rigorous in derivations, nor to give a full historical overview. The idea is to provide a "taste" of cosmology and some of the interesting topics it covers. The standard cosmological model is presented and I highlight the successes of cosmology over the past decade or so. Keys to the development of the standard cosmological model are observations of the cosmic microwave background and of large-scale structure, which are introduced. Inflation and dark energy and the outlook for the future are also discussed. Slides from the lectures are available from the school website: physicschool.web.cern.ch/PhysicSchool/CLASHEP/CLASHEP2011/.

  11. Friedman's cosmological views

    International Nuclear Information System (INIS)

    Heller, M.

    1985-01-01

    Two Friedman's cosmological papers (1922, 1924) and his own interpretation of the obtained results are briefly reviewed. Discussion follows of Friedman's role in the early development of relativistic cosmology. 18 refs. (author)

  12. Galileon cosmology

    International Nuclear Information System (INIS)

    Chow, Nathan; Khoury, Justin

    2009-01-01

    We study the cosmology of a galileon scalar-tensor theory, obtained by covariantizing the decoupling Lagrangian of the Dvali-Gabadadze-Poratti (DGP) model. Despite being local in 3+1 dimensions, the resulting cosmological evolution is remarkably similar to that of the full 4+1-dimensional DGP framework, both for the expansion history and the evolution of density perturbations. As in the DGP model, the covariant galileon theory yields two branches of solutions, depending on the sign of the galileon velocity. Perturbations are stable on one branch and ghostlike on the other. An interesting effect uncovered in our analysis is a cosmological version of the Vainshtein screening mechanism: at early times, the galileon dynamics are dominated by self-interaction terms, resulting in its energy density being suppressed compared to matter or radiation; once the matter density has redshifted sufficiently, the galileon becomes an important component of the energy density and contributes to dark energy. We estimate conservatively that the resulting expansion history is consistent with the observed late-time cosmology, provided that the scale of modification satisfies r c > or approx. 15 Gpc.

  13. Particle physics and cosmology

    International Nuclear Information System (INIS)

    Schramm, D.N.; Turner, M.S.

    1982-06-01

    work is described in these areas: cosmological baryon production; cosmological production of free quarks and other exotic particle species; the quark-hadron transition in the early universe; astrophysical and cosmological constraints on particle properties; massive neutrinos; phase transitions in the early universe; and astrophysical implications of an axion-like particle

  14. Open problems in string cosmology

    International Nuclear Information System (INIS)

    Toumbas, N.

    2010-01-01

    Some of the open problems in string cosmology are highlighted within the context of the recently constructed thermal and quantum superstring cosmological solutions. Emphasis is given on the high temperature cosmological regime, where it is argued that thermal string vacua in the presence of gravito-magnetic fluxes can be used to bypass the Hagedorn instabilities of string gas cosmology. This article is based on a talk given at the workshop on ''Cosmology and Strings'', Corfu, September 6-13, 2009. (Abstract Copyright [2010], Wiley Periodicals, Inc.)

  15. Crucial test of the Dirac cosmologies

    International Nuclear Information System (INIS)

    Steigman, G.

    1978-01-01

    In a cosmology consistent with the Cosmological Principle (large scale, statistical isotropy and homogeneity of the universe), a Planck spectrum is not preserved as the universe evolves unless the number of photons in a comoving volume is conserved. It is shown that a large class of cosmological models based on Dirac's Large Numbers Hypothesis (LNH) violate this constraint. The observed isotropy and spectral distribution of the microwave background radiation thus provide a crucial test of such cosmologies. After reviewing the LNH, the general evolution of radiation spectra in cosmologies consistent with the cosmological principle is outlined. It is shown that the predicted deviations from a Planck spectrum for Dirac cosmologies (as well as for ''tired-light'' cosmologies) are enormous. The Planckian (or near-Planckian) spectral form for the microwave radiation provides a crucial test, failed by such cosmologies

  16. Multi-dimensional cosmology and GUP

    International Nuclear Information System (INIS)

    Zeynali, K.; Motavalli, H.; Darabi, F.

    2012-01-01

    We consider a multidimensional cosmological model with FRW type metric having 4-dimensional space-time and d-dimensional Ricci-flat internal space sectors with a higher dimensional cosmological constant. We study the classical cosmology in commutative and GUP cases and obtain the corresponding exact solutions for negative and positive cosmological constants. It is shown that for negative cosmological constant, the commutative and GUP cases result in finite size universes with smaller size and longer ages, and larger size and shorter age, respectively. For positive cosmological constant, the commutative and GUP cases result in infinite size universes having late time accelerating behavior in good agreement with current observations. The accelerating phase starts in the GUP case sooner than the commutative case. In both commutative and GUP cases, and for both negative and positive cosmological constants, the internal space is stabilized to the sub-Planck size, at least within the present age of the universe. Then, we study the quantum cosmology by deriving the Wheeler-DeWitt equation, and obtain the exact solutions in the commutative case and the perturbative solutions in GUP case, to first order in the GUP small parameter, for both negative and positive cosmological constants. It is shown that good correspondence exists between the classical and quantum solutions

  17. Multi-dimensional cosmology and GUP

    Energy Technology Data Exchange (ETDEWEB)

    Zeynali, K.; Motavalli, H. [Department of Theoretical Physics and Astrophysics, University of Tabriz, 51666-16471, Tabriz (Iran, Islamic Republic of); Darabi, F., E-mail: k.zeinali@arums.ac.ir, E-mail: f.darabi@azaruniv.edu, E-mail: motavalli@tabrizu.ac.ir [Department of Physics, Azarbaijan Shahid Madani University, 53714-161, Tabriz (Iran, Islamic Republic of)

    2012-12-01

    We consider a multidimensional cosmological model with FRW type metric having 4-dimensional space-time and d-dimensional Ricci-flat internal space sectors with a higher dimensional cosmological constant. We study the classical cosmology in commutative and GUP cases and obtain the corresponding exact solutions for negative and positive cosmological constants. It is shown that for negative cosmological constant, the commutative and GUP cases result in finite size universes with smaller size and longer ages, and larger size and shorter age, respectively. For positive cosmological constant, the commutative and GUP cases result in infinite size universes having late time accelerating behavior in good agreement with current observations. The accelerating phase starts in the GUP case sooner than the commutative case. In both commutative and GUP cases, and for both negative and positive cosmological constants, the internal space is stabilized to the sub-Planck size, at least within the present age of the universe. Then, we study the quantum cosmology by deriving the Wheeler-DeWitt equation, and obtain the exact solutions in the commutative case and the perturbative solutions in GUP case, to first order in the GUP small parameter, for both negative and positive cosmological constants. It is shown that good correspondence exists between the classical and quantum solutions.

  18. A savour of Cosmology

    International Nuclear Information System (INIS)

    Langer, M.

    2007-01-01

    This is a very concise introductory lecture to Cosmology. We start by reviewing the basics of homogeneous and isotropic cosmology. We then spend some time on the description of the Cosmic Microwave Background. Finally, a small section is devoted to the discussion of the cosmological constant and of some of the related problems

  19. Neutrino mass from Cosmology

    CERN Document Server

    Lesgourgues, Julien

    2012-01-01

    Neutrinos can play an important role in the evolution of the Universe, modifying some of the cosmological observables. In this contribution we summarize the main aspects of cosmological relic neutrinos and we describe how the precision of present cosmological data can be used to learn about neutrino properties, in particular their mass, providing complementary information to beta decay and neutrinoless double-beta decay experiments. We show how the analysis of current cosmological observations, such as the anisotropies of the cosmic microwave background or the distribution of large-scale structure, provides an upper bound on the sum of neutrino masses of order 1 eV or less, with very good perspectives from future cosmological measurements which are expected to be sensitive to neutrino masses well into the sub-eV range.

  20. Cosmological Models and Stability

    Science.gov (United States)

    Andersson, Lars

    Principles in the form of heuristic guidelines or generally accepted dogma play an important role in the development of physical theories. In particular, philosophical considerations and principles figure prominently in the work of Albert Einstein. As mentioned in the talk by Jiří Bičák at this conference, Einstein formulated the equivalence principle, an essential step on the road to general relativity, during his time in Prague 1911-1912. In this talk, I would like to discuss some aspects of cosmological models. As cosmology is an area of physics where "principles" such as the "cosmological principle" or the "Copernican principle" play a prominent role in motivating the class of models which form part of the current standard model, I will start by comparing the role of the equivalence principle to that of the principles used in cosmology. I will then briefly describe the standard model of cosmology to give a perspective on some mathematical problems and conjectures on cosmological models, which are discussed in the later part of this paper.

  1. Late-onset Tay-Sachs disease: phenotypic characterization and genotypic correlations in 21 affected patients.

    Science.gov (United States)

    Neudorfer, Orit; Pastores, Gregory M; Zeng, Bai J; Gianutsos, John; Zaroff, Charles M; Kolodny, Edwin H

    2005-02-01

    The purpose of this study was to describe the phenotype (and corresponding genotype) of adult patients with late-onset Tay-Sachs disease, a clinical variant of the GM2-gangliosidoses. A comprehensive physical examination, including neurological assessments, was performed to establish the current disease pattern and severity. In addition, the patients' past medical histories were reviewed. The patients' alpha-subunit mutations (beta-Hexosaminidase A genotype) were determined and correlated with their corresponding clinical findings and disease course. Twenty-one patients (current mean age: 27.0 years; range: 14-47 years) were identified. The pedigree revealed a relative with the "classic" infantile or late-onset form of Tay-Sachs disease in four (out of 18) unrelated families. The patients were predominantly male (15/21 individuals) and of Ashkenazi Jewish ancestry (15/18 families). Mean age at onset was 18.1 years; balance problems and difficulty climbing stairs were the most frequent presenting complaints. In several cases, the diagnosis was delayed (mean age at diagnosis: 27.0 years). Analysis of the beta-hex A gene revealed the G269S mutation as the most common disease allele; found in homozygosity (N = 1) or heterozygosity (N = 18; including 2 sib pairs). Disease onset (age 36 years) was delayed and progression relatively slower in the homozygous G269S patient. Two siblings (ages 28 and 31 years), of non-Jewish ancestry, were compound heterozygotes (TATC1278/W474C); their clinical course is dominated by psychiatric problems. Brain imaging studies revealed marked cerebellar atrophy in all patients (N = 18) tested, regardless of disease stage. Late-onset Tay-Sachs disease is an infrequent disorder and the diagnosis is often missed or delayed (by approximately 8 years). Early on, the majority of patients develop signs of either cerebellar or anterior motor neuron involvement. Affected individuals may also develop psychotic episodes. In most cases, the later

  2. Phantom cosmologies and fermions

    International Nuclear Information System (INIS)

    Chimento, Luis P; Forte, Monica; Devecchi, Fernando P; Kremer, Gilberto M

    2008-01-01

    Form invariance transformations can be used for constructing phantom cosmologies starting with conventional cosmological models. In this work we reconsider the scalar field case and extend the discussion to fermionic fields, where the 'phantomization' process exhibits a new class of possible accelerated regimes. As an application we analyze the cosmological constant group for a fermionic seed fluid

  3. Haematopoietic Stem Cell Transplantation Arrests the Progression of Neurodegenerative Disease in Late-Onset Tay-Sachs Disease.

    Science.gov (United States)

    Stepien, Karolina M; Lum, Su Han; Wraith, J Edmond; Hendriksz, Christian J; Church, Heather J; Priestman, David; Platt, Frances M; Jones, Simon; Jovanovic, Ana; Wynn, Robert

    2017-12-07

    Tay-Sachs disease is a rare metabolic disease caused by a deficiency of hexosaminidase A that leads to accumulation of GM2 gangliosides predominantly in neural tissue. Late-onset Tay-Sachs disease variant is associated with a higher level of residual HexA activity. Treatment options are limited, and there are a few described cases who have undergone haematopoietic stem cell transplantation (HSCT) with variable outcome.We describe a case of a 23-year-old male patient who presented with a long-standing tremor since 7 years of age. He had gait ataxia, a speech stammer and swallowing problems. His condition had had a static course apart from his tremor that had been gradually deteriorating. Because of the deterioration in his neurological function, the patient had an uneventful, matched-sibling donor bone marrow transplant at the age of 15 years. Eight years post-HSCT, at the age of 23, he retains full donor engraftment, and his white cell beta-HexA of 191 nmol/mg/h is comparable to normal controls (in-assay control = 187). He continues to experience some intentional tremor that is tolerable for daily life and nonprogressive since HSCT. HSCT is a potential treatment option which might arrest neurodegeneration in patients with LOTS.

  4. Constraints on cosmological parameters in power-law cosmology

    International Nuclear Information System (INIS)

    Rani, Sarita; Singh, J.K.; Altaibayeva, A.; Myrzakulov, R.; Shahalam, M.

    2015-01-01

    In this paper, we examine observational constraints on the power law cosmology; essentially dependent on two parameters H 0 (Hubble constant) and q (deceleration parameter). We investigate the constraints on these parameters using the latest 28 points of H(z) data and 580 points of Union2.1 compilation data and, compare the results with the results of ΛCDM . We also forecast constraints using a simulated data set for the future JDEM, supernovae survey. Our studies give better insight into power law cosmology than the earlier done analysis by Kumar [arXiv:1109.6924] indicating it tuning well with Union2.1 compilation data but not with H(z) data. However, the constraints obtained on and i.e. H 0 average and q average using the simulated data set for the future JDEM, supernovae survey are found to be inconsistent with the values obtained from the H(z) and Union2.1 compilation data. We also perform the statefinder analysis and find that the power-law cosmological models approach the standard ΛCDM model as q → −1. Finally, we observe that although the power law cosmology explains several prominent features of evolution of the Universe, it fails in details

  5. Quantum cosmological models

    International Nuclear Information System (INIS)

    Coule, D H

    2005-01-01

    We contrast the initial condition requirements of various contemporary cosmological models including inflationary and bouncing cosmologies. Canonical quantization of general relativity is used, as a first approximation to full quantum gravity, to determine whether suitable initial conditions are present. Various proposals such as Hartle-Hawking's 'no boundary' or tunnelling boundary conditions are assessed on grounds of naturalness and fine tuning. Alternatively, a quiescent initial state or an initial closed timelike curve 'time machine' is considered. Possible extensions to brane models are also addressed. Further ideas about universe creation from a meta-universe are outlined. Semiclassical and time asymmetry requirements of cosmology are briefly discussed and contrasted with the black-hole final-state proposal. We compare the recent loop quantum cosmology of Bojowald and co-workers with these earlier schemes. A number of possible difficulties and limitations are outlined. (topical review)

  6. A varying-α brane world cosmology

    International Nuclear Information System (INIS)

    Youm, Donam

    2001-08-01

    We study the brane world cosmology in the RS2 model where the electric charge varies with time in the manner described by the varying fine-structure constant theory of Bekenstein. We map such varying electric charge cosmology to the dual variable-speed-of-light cosmology by changing system of units. We comment on cosmological implications for such cosmological models. (author)

  7. Projective relativity, cosmology and gravitation

    International Nuclear Information System (INIS)

    Arcidiacono, G.

    1986-01-01

    This book describes the latest applications of projective geometry to cosmology and gravitation. The contents of the book are; the Poincare group and Special Relativity, the thermodynamics and electromagnetism, general relativity, gravitation and cosmology, group theory and models of universe, the special projective relativity, the Fantappie group and Big-Bang cosmology, a new cosmological projective mechanics, the plasma physics and cosmology, the projective magnetohydrodynamics field, projective relativity and waves propagation, the generalizations of the gravitational field, the general projective relativity, the projective gravitational field, the De Sitter Universe and quantum physics, the conformal relativity and Newton gravitation

  8. On estimating cosmology-dependent covariance matrices

    International Nuclear Information System (INIS)

    Morrison, Christopher B.; Schneider, Michael D.

    2013-01-01

    We describe a statistical model to estimate the covariance matrix of matter tracer two-point correlation functions with cosmological simulations. Assuming a fixed number of cosmological simulation runs, we describe how to build a 'statistical emulator' of the two-point function covariance over a specified range of input cosmological parameters. Because the simulation runs with different cosmological models help to constrain the form of the covariance, we predict that the cosmology-dependent covariance may be estimated with a comparable number of simulations as would be needed to estimate the covariance for fixed cosmology. Our framework is a necessary first step in planning a simulations campaign for analyzing the next generation of cosmological surveys

  9. Classical and quantum cosmology

    CERN Document Server

    Calcagni, Gianluca

    2017-01-01

    This comprehensive textbook is devoted to classical and quantum cosmology, with particular emphasis on modern approaches to quantum gravity and string theory and on their observational imprint. It covers major challenges in theoretical physics such as the big bang and the cosmological constant problem. An extensive review of standard cosmology, the cosmic microwave background, inflation and dark energy sets the scene for the phenomenological application of all the main quantum-gravity and string-theory models of cosmology. Born of the author's teaching experience and commitment to bridging the gap between cosmologists and theoreticians working beyond the established laws of particle physics and general relativity, this is a unique text where quantum-gravity approaches and string theory are treated on an equal footing. As well as introducing cosmology to undergraduate and graduate students with its pedagogical presentation and the help of 45 solved exercises, this book, which includes an ambitious bibliography...

  10. Wormholes and cosmology

    International Nuclear Information System (INIS)

    Klebanov, I.; Susskind, L.

    1988-10-01

    We review Coleman's wormhole mechanism for the vanishing of the cosmological constant. We find a discouraging result that wormholes much bigger than the Planck size are generated. We also consider the implications of the wormhole theory for cosmology. 7 refs., 2 figs

  11. Axions in inflationary cosmology

    International Nuclear Information System (INIS)

    Linde, A.

    1991-01-01

    The problem of the cosmological constraints on the axion mass is re-examined. It is argued that in the context of inflationary cosmology the constraint m a > or approx.10 -5 eV can be avoided even when the axion perturbations produced during inflation are taken into account. It is shown also that in most axion models the effective parameter f a rapidly changes during inflation. This modifies some earlier statements concerning isothermal perturbations in the axion cosmology. A hybrid inflation scenario is proposed which combines some advantages of chaotic inflation with specific features of new and/or extended inflation. Its implications for the axion cosmology are discussed. (orig.)

  12. Testing cosmology with galaxy clusters

    DEFF Research Database (Denmark)

    Rapetti Serra, David Angelo

    2011-01-01

    PASCOS 2011 will be held in Cambridge UK. The conference will be hosted by the Centre for Theoretical Cosmology (DAMTP) at the Mathematical Sciences site in the University of Cambridge. The aim of the conference is to explore and develop synergies between particle physics, string theory and cosmo......PASCOS 2011 will be held in Cambridge UK. The conference will be hosted by the Centre for Theoretical Cosmology (DAMTP) at the Mathematical Sciences site in the University of Cambridge. The aim of the conference is to explore and develop synergies between particle physics, string theory...... and cosmology. There will be an emphasis on timely interdisciplinary topics: • critical tests of inflationary cosmology • advances in fundamental cosmology • applications of string theory (AdS/CMT) • particle and string phenomenology • new experimental particle physics results • and cosmological probes...

  13. Introduction to cosmology

    CERN Document Server

    Ryden, Barbara

    2017-01-01

    This second edition of Introduction to Cosmology is an exciting update of an award-winning textbook. It is aimed primarily at advanced undergraduate students in physics and astronomy, but is also useful as a supplementary text at higher levels. It explains modern cosmological concepts, such as dark energy, in the context of the Big Bang theory. Its clear, lucid writing style, with a wealth of useful everyday analogies, makes it exceptionally engaging. Emphasis is placed on the links between theoretical concepts of cosmology and the observable properties of the universe, building deeper physical insights in the reader. The second edition includes recent observational results, fuller descriptions of special and general relativity, expanded discussions of dark energy, and a new chapter on baryonic matter that makes up stars and galaxies. It is an ideal textbook for the era of precision cosmology in the accelerating universe.

  14. Everyone's guide to cosmology

    International Nuclear Information System (INIS)

    Davies, P.

    1991-01-01

    The main concepts of cosmology are discussed, and some of the misconceptions are clarified. The features of big bang cosmology are examined, and it is noted that the existence of the cosmic background radiation provides welcome confirmation of the big bang theory. Calculations of relative abundances of the elements conform with observations, further strengthening the confidence in the basic ideas of big bang cosmology

  15. Cosmological applications in Kaluza—Klein theory

    International Nuclear Information System (INIS)

    Wanas, M.I.; Nashed, Gamal G. L.; Nowaya, A.A.

    2012-01-01

    The field equations of Kaluza—Klein (KK) theory have been applied in the domain of cosmology. These equations are solved for a flat universe by taking the gravitational and the cosmological constants as a function of time t. We use Taylor's expansion of cosmological function, Λ(t), up to the first order of the time t. The cosmological parameters are calculated and some cosmological problems are discussed. (geophysics, astronomy, and astrophysics)

  16. Conformal symmetry and holographic cosmology

    NARCIS (Netherlands)

    Bzowski, A.W.

    2013-01-01

    This thesis presents a novel approach to cosmology using gauge/gravity duality. Analysis of the implications of conformal invariance in field theories leads to quantitative cosmological predictions which are in agreement with current data. Furthermore, holographic cosmology extends the theory of

  17. The cosmological term and a modified Brans-Dicke cosmology

    International Nuclear Information System (INIS)

    Endo, M.; Fukui, T.

    1977-01-01

    Adding the cosmological term Λ, which is assumed to be variable in this paper, to the Brans-Dicke Lagrangian, an attempt is made to understand the meaning of the term and to relate it to the mass of the universe. The Dirac large-number hypothesis is considered, applying the results obtained from the application of the present theory to a uniform cosmological model. (author)

  18. iCosmo: an interactive cosmology package

    Science.gov (United States)

    Refregier, A.; Amara, A.; Kitching, T. D.; Rassat, A.

    2011-04-01

    Aims: The interactive software package iCosmo, designed to perform cosmological calculations is described. Methods: iCosmo is a software package to perfom interactive cosmological calculations for the low-redshift universe. Computing distance measures, the matter power spectrum, and the growth factor is supported for any values of the cosmological parameters. It also computes derived observed quantities for several cosmological probes such as cosmic shear, baryon acoustic oscillations, and type Ia supernovae. The associated errors for these observable quantities can be derived for customised surveys, or for pre-set values corresponding to current or planned instruments. The code also allows for calculation of cosmological forecasts with Fisher matrices, which can be manipulated to combine different surveys and cosmological probes. The code is written in the IDL language and thus benefits from the convenient interactive features and scientific libraries available in this language. iCosmo can also be used as an engine to perform cosmological calculations in batch mode, and forms a convenient adaptive platform for the development of further cosmological modules. With its extensive documentation, it may also serve as a useful resource for teaching and for newcomers to the field of cosmology. Results: The iCosmo package is described with a number of examples and command sequences. The code is freely available with documentation at http://www.icosmo.org, along with an interactive web interface and is part of the Initiative for Cosmology, a common archive for cosmological resources.

  19. Is the cosmological singularity compulsory

    International Nuclear Information System (INIS)

    Bekenstein, J.D.; Meisels, A.

    1980-01-01

    The cosmological singularity is inherent in all conventional general relativistic cosmological models. There can be no question that it is an unphysical feature; yet there does not seem to be any convervative way of eliminating it. Here we present singularity-free isotropic cosmological models which are indistinguishable from general relativistic ones at late times. They are based on the general theory of variable rest masses that we developed recently. Outside cosmology this theory simulates general relativity well. Thus it provides a framework incorporating those features which have made geneal relativity so sucessful while providing a way out of singularity dilemma. The cosmological models can be made to incorporate Dirac's large numbers hypothesis. G(now)/G(0)approx.10 -38

  20. Cosmology solved? Maybe

    International Nuclear Information System (INIS)

    Turner, Michael S.

    1999-01-01

    For two decades the hot big-bang model as been referred to as the standard cosmology - and for good reason. For just as long cosmologists have known that there are fundamental questions that are not answered by the standard cosmology and point to a grander theory. The best candidate for that grander theory is inflation + cold dark matter. It holds that the Universe is flat, that slowly moving elementary particles left over from the earliest moments provide the cosmic infrastructure, and that the primeval density inhomogeneities that seed all the structure arose from quantum fluctuations. There is now prima facie evidence that supports two basic tenets of this paradigm. An avalanche of high-quality cosmological observations will soon make this case stronger or will break it. Key questions remain to be answered; foremost among them are: identification and detection of the cold dark matter particles and elucidation of the dark-energy component. These are exciting times in cosmology!

  1. Cosmology solved? Maybe

    Energy Technology Data Exchange (ETDEWEB)

    Turner, Michael S

    1999-03-01

    For two decades the hot big-bang model as been referred to as the standard cosmology - and for good reason. For just as long cosmologists have known that there are fundamental questions that are not answered by the standard cosmology and point to a grander theory. The best candidate for that grander theory is inflation + cold dark matter. It holds that the Universe is flat, that slowly moving elementary particles left over from the earliest moments provide the cosmic infrastructure, and that the primeval density inhomogeneities that seed all the structure arose from quantum fluctuations. There is now prima facie evidence that supports two basic tenets of this paradigm. An avalanche of high-quality cosmological observations will soon make this case stronger or will break it. Key questions remain to be answered; foremost among them are: identification and detection of the cold dark matter particles and elucidation of the dark-energy component. These are exciting times in cosmology{exclamation_point}.

  2. On the structure and applications of the Bondi-Metzner-Sachs group

    Science.gov (United States)

    Alessio, Francesco; Esposito, Giampiero

    This work is a pedagogical review dedicated to a modern description of the Bondi-Metzner-Sachs (BMS) group. Minkowski space-time has an interesting and useful group of isometries, but, for a generic space-time, the isometry group is simply the identity and hence provides no significant informations. Yet symmetry groups have important role to play in physics; in particular, the Poincaré group describing the isometries of Minkowski space-time plays a role in the standard definitions of energy-momentum and angular-momentum. For this reason alone it would seem to be important to look for a generalization of the concept of isometry group that can apply in a useful way to suitable curved space-times. The curved space-times that will be taken into account are the ones that suitably approach, at infinity, Minkowski space-time. In particular we will focus on asymptotically flat space-times. In this work, the concept of asymptotic symmetry group of those space-times will be studied. In the first two sections we derive the asymptotic group following the classical approach which was basically developed by Bondi, van den Burg, Metzner and Sachs. This is essentially the group of transformations between coordinate systems of a certain type in asymptotically flat space-times. In the third section the conformal method and the notion of “asymptotic simplicity” are introduced, following mainly the works of Penrose. This section prepares us for another derivation of the BMS group which will involve the conformal structure, and is thus more geometrical and fundamental. In the subsequent sections we discuss the properties of the BMS group, e.g. its algebra and the possibility to obtain as its subgroup the Poincaré group, as we may expect. The paper ends with a review of the BMS invariance properties of classical gravitational scattering discovered by Strominger, that are finding application to black hole physics and quantum gravity in the literature.

  3. Partial rip scenario - a cosmology with a growing cosmological term

    International Nuclear Information System (INIS)

    Stefancic, H.

    2004-01-01

    A cosmology with the growing cosmological term is considered. If there is no exchange of energy between vacuum and matter components, the requirement of general covariance implies the time dependence of the gravitational constant G. Irrespectively of the exact functional form of the cosmological term growth, the universe ends in a de Sitter regime with a constant asymptotic Λ, but vanishing G. Although there is no divergence of the scale factor in finite time, such as in the 'Big Rip' scenario, gravitationally bound systems eventually become unbound. In the case of systems bound by non-gravitational forces, there is no unbounding effect, as the asymptotic Λ is insufficiently large to disturb these systems

  4. Axion cold dark matter in nonstandard cosmologies

    International Nuclear Information System (INIS)

    Visinelli, Luca; Gondolo, Paolo

    2010-01-01

    We study the parameter space of cold dark matter axions in two cosmological scenarios with nonstandard thermal histories before big bang nucleosynthesis: the low-temperature reheating (LTR) cosmology and the kination cosmology. If the Peccei-Quinn symmetry breaks during inflation, we find more allowed parameter space in the LTR cosmology than in the standard cosmology and less in the kination cosmology. On the contrary, if the Peccei-Quinn symmetry breaks after inflation, the Peccei-Quinn scale is orders of magnitude higher than standard in the LTR cosmology and lower in the kination cosmology. We show that the axion velocity dispersion may be used to distinguish some of these nonstandard cosmologies. Thus, axion cold dark matter may be a good probe of the history of the Universe before big bang nucleosynthesis.

  5. Cosmology and the early universe

    CERN Document Server

    Di Bari, Pasquale

    2018-01-01

    This book discusses cosmology from both an observational and a strong theoretical perspective. The first part focuses on gravitation, notably the expansion of the universe and determination of cosmological parameters, before moving onto the main emphasis of the book, the physics of the early universe, and the connections between cosmological models and particle physics. Readers will gain a comprehensive account of cosmology and the latest observational results, without requiring prior knowledge of relativistic theories, making the text ideal for students.

  6. Antimatter and cosmology

    International Nuclear Information System (INIS)

    Stecker, F.W.

    1989-01-01

    This paper discusses two aspects of antimatter and cosmology: 1. the fundamental cosmological question as to whether antimatter plays an equally important role as matter in the universe (overall baryon symmetry), and 2. cosmic-ray antimatter tests for the nature of the dark matter in the universe. (orig.)

  7. The Bright Universe Cosmology

    International Nuclear Information System (INIS)

    Surdin, M.

    1980-01-01

    It is shown that viewed from the 'outside', our universe is a black hole. Hence the 'inside' cosmology considered is termed as the Bright Universe Cosmology. The model proposed avoids the singularities of cosmologies of the Big Bang variety, it gives a good account of the redshifts, the cosmic background radiation, the number counts; it also gives a satisfactory explanation of the 'large numbers coincidence' and of the variation in time of fundamental constants. (Auth.)

  8. Friedmann cosmology with a cosmological 'constant' in the scale covariant theory

    International Nuclear Information System (INIS)

    Beesham, A.

    1986-01-01

    Homogeneous isotropic cosmologies in the presence of a cosmological 'constant' are studied in the scale covariant theory. A class of solutions is obtained for kappa = 0 for models filled with dust, radiation or stiff matter. For kappa not= 0, solutions are presented for the radiation models. (author)

  9. Cosmological Reflection of Particle Symmetry

    Directory of Open Access Journals (Sweden)

    Maxim Khlopov

    2016-08-01

    Full Text Available The standard model involves particle symmetry and the mechanism of its breaking. Modern cosmology is based on inflationary models with baryosynthesis and dark matter/energy, which involves physics beyond the standard model. Studies of the physical basis of modern cosmology combine direct searches for new physics at accelerators with its indirect non-accelerator probes, in which cosmological consequences of particle models play an important role. The cosmological reflection of particle symmetry and the mechanisms of its breaking are the subject of the present review.

  10. Cosmological Probes for Supersymmetry

    Directory of Open Access Journals (Sweden)

    Maxim Khlopov

    2015-05-01

    Full Text Available The multi-parameter character of supersymmetric dark-matter models implies the combination of their experimental studies with astrophysical and cosmological probes. The physics of the early Universe provides nontrivial effects of non-equilibrium particles and primordial cosmological structures. Primordial black holes (PBHs are a profound signature of such structures that may arise as a cosmological consequence of supersymmetric (SUSY models. SUSY-based mechanisms of baryosynthesis can lead to the possibility of antimatter domains in a baryon asymmetric Universe. In the context of cosmoparticle physics, which studies the fundamental relationship of the micro- and macro-worlds, the development of SUSY illustrates the main principles of this approach, as the physical basis of the modern cosmology provides cross-disciplinary tests in physical and astronomical studies.

  11. Current cosmology

    International Nuclear Information System (INIS)

    Zeldovich, Ya.

    1984-01-01

    The knowledge is summed up of contemporary cosmology on the universe and its development resulting from a great number of highly sensitive observations and the application of contemporary physical theories to the entire universe. The questions are assessed of mass density in the universe, the structure and origin of the universe, its baryon asymmetry and the quantum explanation of the origin of the universe. Physical problems are presented which should be resolved for the future development of cosmology. (Ha)

  12. Particle cosmology

    CERN Multimedia

    CERN. Geneva

    2007-01-01

    The understanding of the Universe at the largest and smallest scales traditionally has been the subject of cosmology and particle physics, respectively. Studying the evolution of the Universe connects today's large scales with the tiny scales in the very early Universe and provides the link between the physics of particles and of the cosmos. This series of five lectures aims at a modern and critical presentation of the basic ideas, methods, models and observations in today's particle cosmology.

  13. Perspectives in cosmology

    International Nuclear Information System (INIS)

    Vilenkin, Alexander

    2010-01-01

    The n ew standard cosmology , based on the theory of inflation, has very impressive observational support. I review some outstanding problems of the new cosmology and the global view of the universe - the multiverse - that it suggests. I focus in particular on prospects for further observational tests of inflation and of the multiverse.

  14. Quark matter and cosmology

    International Nuclear Information System (INIS)

    Schramm, D.N.; Fields, B.; Thomas, D.

    1992-01-01

    The possible implications of the quark-hadron transition for cosmology are explored. Possible surviving signatures are discussed. In particular, the possibility of generating a dark matter candidate such as strange nuggets or planetary mass black holes is noted. Much discussion is devoted to the possible role of the transition for cosmological nucleosynthesis. It is emphasized that even an optimized first order phase transition will not significantly alter the nucleosynthesis constraints on the cosmological baryon density nor on neutrino counting. However, it is noted that Be and B observations in old stars may eventually be able to be a signature of a cosmologically significant quark-hadron transition. It is pointed out that the critical point in this regard is whether the observed B/Be ratio can be produced by spallation processes or requires cosmological input. Spallation cannot produce a B/Be ratio below 7.6. A supporting signature would be Be and B ratios to oxygen that greatly exceed galactic values. At present, all data is still consistent with a spallagenic origin

  15. Standard cosmological evolution in the f(R) model to Kaluza-Klein cosmology

    International Nuclear Information System (INIS)

    Aghmohammadi, A; Abolhassani, M R; Saaidi, Kh; Vajdi, A

    2009-01-01

    In this paper, using f(R) theory of gravity we explicitly calculate cosmological evolution in the presence of a perfect fluid source in four- and five-dimensional space-time in which this cosmological evolution in self-creation is presented by Reddy et al (2009 Int. J. Theor. Phys. 48 10). An exact cosmological model is presented using a relation between Einstein's gravity field equation components due to a metric with the same component from f(R) theory of gravity. Some physics and kinematical properties of the model are also discussed.

  16. An introduction to modern cosmology

    CERN Document Server

    Liddle, Andrew

    2015-01-01

    An Introduction to Modern Cosmology Third Edition is an accessible account of modern cosmological ideas. The Big Bang Cosmology is explored, looking at its observational successes in explaining the expansion of the Universe, the existence and properties of the cosmic microwave background, and the origin of light elements in the universe. Properties of the very early Universe are also covered, including the motivation for a rapid period of expansion known as cosmological inflation. The third edition brings this established undergraduate textbook up-to-date with the rapidly evolving observation

  17. Perturbations in loop quantum cosmology

    International Nuclear Information System (INIS)

    Nelson, W; Agullo, I; Ashtekar, A

    2014-01-01

    The era of precision cosmology has allowed us to accurately determine many important cosmological parameters, in particular via the CMB. Confronting Loop Quantum Cosmology with these observations provides us with a powerful test of the theory. For this to be possible, we need a detailed understanding of the generation and evolution of inhomogeneous perturbations during the early, quantum gravity phase of the universe. Here, we have described how Loop Quantum Cosmology provides a completion of the inflationary paradigm, that is consistent with the observed power spectra of the CMB

  18. An introduction to cosmology

    CERN Document Server

    Kunze, Kerstin E.

    2016-12-20

    Cosmology is becoming an important tool to test particle physics models. We provide an overview of the standard model of cosmology with an emphasis on the observations relevant for testing fundamental physics.

  19. Cosmological horizons, quintessence and string theory

    International Nuclear Information System (INIS)

    Kaloper, Nemanja

    2003-01-01

    String theory is presently the best candidate for a quantum theory of gravity unified with other forces. It is natural to hope that applications of string theory to cosmology may shed new light on the cosmological conundra, such as singularities, initial conditions, cosmological constant problem and the origin of inflation. Before we can apply string theory to cosmology, there are important conceptual and practical problems which must be addressed. We have reviewed here some of these problems, related to how one defines string theory in a cosmological setting. (author)

  20. Quintessence and the cosmological constant

    International Nuclear Information System (INIS)

    Doran, M.; Wetterich, C.

    2003-01-01

    Quintessence -- the energy density of a slowly evolving scalar field -- may constitute a dynamical form of the homogeneous dark energy in the universe. We review the basic idea in the light of the cosmological constant problem. Cosmological observations or a time variation of fundamental 'constants' can distinguish quintessence from a cosmological constant

  1. Perspectives in cosmology

    Energy Technology Data Exchange (ETDEWEB)

    Vilenkin, Alexander, E-mail: vilenkin@cosmos.phy.tufts.ed [Institute of Cosmology, Department of Physics and Astronomy, Tufts University, Medford, MA 02155 (United States)

    2010-01-01

    The 'new standard cosmology', based on the theory of inflation, has very impressive observational support. I review some outstanding problems of the new cosmology and the global view of the universe - the multiverse - that it suggests. I focus in particular on prospects for further observational tests of inflation and of the multiverse.

  2. Inflation and quantum cosmology

    International Nuclear Information System (INIS)

    Linde, A.

    1991-01-01

    In this article a review of the present status of inflationary cosmology is given. We start with a discussion of the simplest version of the chaotic inflation scenario. Then we discuss some recent develoments in the inflationary cosmology, including the theory of a self-reproducing inflationary universe (eternal chaotic inflation). We do it with the help of stochastic approach to inflation. The results obtained within this approach are compared with the results obtained in the context of Euclidean quantum cosmology. (WL)

  3. Cosmological dynamical systems

    CERN Document Server

    Leon, Genly

    2011-01-01

    In this book are studied, from the perspective of the dynamical systems, several Universe models. In chapter 1 we give a bird's eye view on cosmology and cosmological problems. Chapter 2 is devoted to a brief review on some results and useful tools from the qualitative theory of dynamical systems. They provide the theoretical basis for the qualitative study of concrete cosmological models. Chapters 1 and 2 are a review of well-known results. Chapters 3, 4, 5 and 6 are devoted to our main results. In these chapters are extended and settled in a substantially different, more strict mathematical language, several results obtained by one of us in arXiv:0812.1013 [gr-qc]; arXiv:1009.0689 [gr-qc]; arXiv:0904.1577[gr-qc]; and arXiv:0909.3571 [hep-th]. In chapter 6, we provide a different approach to the subject discussed in astro-ph/0503478. Additionally, we perform a Poincar\\'e compactification process allowing to construct a global phase space containing all the cosmological information in both finite and infinite...

  4. Graviton fluctuations erase the cosmological constant

    Science.gov (United States)

    Wetterich, C.

    2017-10-01

    Graviton fluctuations induce strong non-perturbative infrared renormalization effects for the cosmological constant. The functional renormalization flow drives a positive cosmological constant towards zero, solving the cosmological constant problem without the need to tune parameters. We propose a simple computation of the graviton contribution to the flow of the effective potential for scalar fields. Within variable gravity, with effective Planck mass proportional to the scalar field, we find that the potential increases asymptotically at most quadratically with the scalar field. The solutions of the derived cosmological equations lead to an asymptotically vanishing cosmological "constant" in the infinite future, providing for dynamical dark energy in the present cosmological epoch. Beyond a solution of the cosmological constant problem, our simplified computation also entails a sizeable positive graviton-induced anomalous dimension for the quartic Higgs coupling in the ultraviolet regime, substantiating the successful prediction of the Higgs boson mass within the asymptotic safety scenario for quantum gravity.

  5. Particle theory and cosmology

    International Nuclear Information System (INIS)

    Gaisser, T.K.; Shafi, Q.; Barr, S.M.; Seckel, D.; Rusjan, E.; Fletcher, R.S.

    1991-01-01

    This report discusses research of professor at Bartol research institute in the following general areas: particle phenomenology and non-accelerator physics; particle physics and cosmology; theories with higher symmetry; and particle astrophysics and cosmology

  6. Was Newtonian cosmology really inconsistent?

    Science.gov (United States)

    Vickers, Peter

    This paper follows up a debate as to the consistency of Newtonian cosmology. Whereas Malament [(1995). Is Newtonian cosmology really inconsistent? Philosophy of Science 62, 489-510] has shown that Newtonian cosmology is not inconsistent, to date there has been no analysis of Norton's claim [(1995). The force of Newtonian cosmology: Acceleration is relative. Philosophy of Science 62, 511-522.] that Newtonian cosmology was inconsistent prior to certain advances in the 1930s, and in particular prior to Seeliger's seminal paper of Seeliger [(1895). Über das Newton'sche Gravitationsgesetz. Astronomische Nachrichten 137 (3273), 129-136.] In this paper I agree that there are assumptions, Newtonian and cosmological in character, and relevant to the real history of science, which are inconsistent. But there are some important corrections to make to Norton's account. Here I display for the first time the inconsistencies-four in total-in all their detail. Although this extra detail shows there to be several different inconsistencies, it also goes some way towards explaining why they went unnoticed for 200 years.

  7. Cosmology. A first course

    Science.gov (United States)

    Lachieze-Rey, Marc

    This book delivers a quantitative account of the science of cosmology, designed for a non-specialist audience. The basic principles are outlined using simple maths and physics, while still providing rigorous models of the Universe. It offers an ideal introduction to the key ideas in cosmology, without going into technical details. The approach used is based on the fundamental ideas of general relativity such as the spacetime interval, comoving coordinates, and spacetime curvature. It provides an up-to-date and thoughtful discussion of the big bang, and the crucial questions of structure and galaxy formation. Questions of method and philosophical approaches in cosmology are also briefly discussed. Advanced undergraduates in either physics or mathematics would benefit greatly from use either as a course text or as a supplementary guide to cosmology courses.

  8. Cosmological constant--the weight of the vacuum

    International Nuclear Information System (INIS)

    Padmanabhan, T.

    2003-01-01

    Recent cosmological observations suggest the existence of a positive cosmological constant Λ with the magnitude Λ(Gℎ/c 3 )∼10 -123 . This review discusses several aspects of the cosmological constant both from the cosmological (Sections 1-6) and field theoretical (Sections 7-11) perspectives. After a brief introduction to the key issues related to cosmological constant and a historical overview, a summary of the kinematics and dynamics of the standard Friedmann model of the universe is provided. The observational evidence for cosmological constant, especially from the supernova results, and the constraints from the age of the universe, structure formation, Cosmic Microwave Background Radiation (CMBR) anisotropies and a few others are described in detail, followed by a discussion of the theoretical models (quintessence, tachyonic scalar field, ...) from different perspectives. The latter part of the review (Sections 7-11) concentrates on more conceptual and fundamental aspects of the cosmological constant like some alternative interpretations of the cosmological constant, relaxation mechanisms to reduce the cosmological constant to the currently observed value, the geometrical structure of the de Sitter spacetime, thermodynamics of the de Sitter universe and the role of string theory in the cosmological constant problem

  9. Deconstructing cosmology

    CERN Document Server

    Sanders, Robert H

    2016-01-01

    The advent of sensitive high-resolution observations of the cosmic microwave background radiation and their successful interpretation in terms of the standard cosmological model has led to great confidence in this model's reality. The prevailing attitude is that we now understand the Universe and need only work out the details. In this book, Sanders traces the development and successes of Lambda-CDM, and argues that this triumphalism may be premature. The model's two major components, dark energy and dark matter, have the character of the pre-twentieth-century luminiferous aether. While there is astronomical evidence for these hypothetical fluids, their enigmatic properties call into question our assumptions of the universality of locally determined physical law. Sanders explains how modified Newtonian dynamics (MOND) is a significant challenge for cold dark matter. Overall, the message is hopeful: the field of cosmology has not become frozen, and there is much fundamental work ahead for tomorrow's cosmologis...

  10. Neutrino properties from cosmology

    CERN Multimedia

    CERN. Geneva

    2013-01-01

    Future, massive large-scale structure survey have been presented and approved.On the theory side, a significant effort has bene devoted to achieve better modeling of small scale clustering that is of cosmological non-linearities. As a result it has become clear that forthcoming cosmological data have enough statitsical power to detect the effect of non-zero neutrino mass (even at the lower mass scale limit imposed by oscillations) and to constrain the absolute neutrino mass scale.Cosmological data can also constrain the numb...

  11. Inhomogeneous anisotropic cosmology

    International Nuclear Information System (INIS)

    Kleban, Matthew; Senatore, Leonardo

    2016-01-01

    In homogeneous and isotropic Friedmann-Robertson-Walker cosmology, the topology of the universe determines its ultimate fate. If the Weak Energy Condition is satisfied, open and flat universes must expand forever, while closed cosmologies can recollapse to a Big Crunch. A similar statement holds for homogeneous but anisotropic (Bianchi) universes. Here, we prove that arbitrarily inhomogeneous and anisotropic cosmologies with “flat” (including toroidal) and “open” (including compact hyperbolic) spatial topology that are initially expanding must continue to expand forever at least in some region at a rate bounded from below by a positive number, despite the presence of arbitrarily large density fluctuations and/or the formation of black holes. Because the set of 3-manifold topologies is countable, a single integer determines the ultimate fate of the universe, and, in a specific sense, most 3-manifolds are “flat” or “open”. Our result has important implications for inflation: if there is a positive cosmological constant (or suitable inflationary potential) and initial conditions for the inflaton, cosmologies with “flat” or “open” topology must expand forever in some region at least as fast as de Sitter space, and are therefore very likely to begin inflationary expansion eventually, regardless of the scale of the inflationary energy or the spectrum and amplitude of initial inhomogeneities and gravitational waves. Our result is also significant for numerical general relativity, which often makes use of periodic (toroidal) boundary conditions.

  12. Parameterized post-Newtonian cosmology

    International Nuclear Information System (INIS)

    Sanghai, Viraj A A; Clifton, Timothy

    2017-01-01

    Einstein’s theory of gravity has been extensively tested on solar system scales, and for isolated astrophysical systems, using the perturbative framework known as the parameterized post-Newtonian (PPN) formalism. This framework is designed for use in the weak-field and slow-motion limit of gravity, and can be used to constrain a large class of metric theories of gravity with data collected from the aforementioned systems. Given the potential of future surveys to probe cosmological scales to high precision, it is a topic of much contemporary interest to construct a similar framework to link Einstein’s theory of gravity and its alternatives to observations on cosmological scales. Our approach to this problem is to adapt and extend the existing PPN formalism for use in cosmology. We derive a set of equations that use the same parameters to consistently model both weak fields and cosmology. This allows us to parameterize a large class of modified theories of gravity and dark energy models on cosmological scales, using just four functions of time. These four functions can be directly linked to the background expansion of the universe, first-order cosmological perturbations, and the weak-field limit of the theory. They also reduce to the standard PPN parameters on solar system scales. We illustrate how dark energy models and scalar-tensor and vector-tensor theories of gravity fit into this framework, which we refer to as ‘parameterized post-Newtonian cosmology’ (PPNC). (paper)

  13. Parameterized post-Newtonian cosmology

    Science.gov (United States)

    Sanghai, Viraj A. A.; Clifton, Timothy

    2017-03-01

    Einstein’s theory of gravity has been extensively tested on solar system scales, and for isolated astrophysical systems, using the perturbative framework known as the parameterized post-Newtonian (PPN) formalism. This framework is designed for use in the weak-field and slow-motion limit of gravity, and can be used to constrain a large class of metric theories of gravity with data collected from the aforementioned systems. Given the potential of future surveys to probe cosmological scales to high precision, it is a topic of much contemporary interest to construct a similar framework to link Einstein’s theory of gravity and its alternatives to observations on cosmological scales. Our approach to this problem is to adapt and extend the existing PPN formalism for use in cosmology. We derive a set of equations that use the same parameters to consistently model both weak fields and cosmology. This allows us to parameterize a large class of modified theories of gravity and dark energy models on cosmological scales, using just four functions of time. These four functions can be directly linked to the background expansion of the universe, first-order cosmological perturbations, and the weak-field limit of the theory. They also reduce to the standard PPN parameters on solar system scales. We illustrate how dark energy models and scalar-tensor and vector-tensor theories of gravity fit into this framework, which we refer to as ‘parameterized post-Newtonian cosmology’ (PPNC).

  14. A new cosmological paradigm: the cosmological constant and dark matter

    International Nuclear Information System (INIS)

    Krauss, L.M.

    1998-01-01

    The Standard Cosmological Model of the 1980 close-quote s is no more. I describe the definitive evidence that the density of matter is insufficient to result in a flat universe, as well as the mounting evidence that the cosmological constant is not zero. I finally discuss the implications of these results for particle physics and direct searches for non-baryonic dark matter. copyright 1998 American Institute of Physics

  15. Tensors, relativity, and cosmology

    CERN Document Server

    Dalarsson, Mirjana

    2015-01-01

    Tensors, Relativity, and Cosmology, Second Edition, combines relativity, astrophysics, and cosmology in a single volume, providing a simplified introduction to each subject that is followed by detailed mathematical derivations. The book includes a section on general relativity that gives the case for a curved space-time, presents the mathematical background (tensor calculus, Riemannian geometry), discusses the Einstein equation and its solutions (including black holes and Penrose processes), and considers the energy-momentum tensor for various solutions. In addition, a section on relativistic astrophysics discusses stellar contraction and collapse, neutron stars and their equations of state, black holes, and accretion onto collapsed objects, with a final section on cosmology discussing cosmological models, observational tests, and scenarios for the early universe. This fully revised and updated second edition includes new material on relativistic effects, such as the behavior of clocks and measuring rods in m...

  16. Neutrino properties from cosmology

    DEFF Research Database (Denmark)

    Hannestad, S.

    2013-01-01

    In recent years precision cosmology has become an increasingly powerful probe of particle physics. Perhaps the prime example of this is the very stringent cosmological upper bound on the neutrino mass. However, other aspects of neutrino physics, such as their decoupling history and possible non......-standard interactions, can also be probed using observations of cosmic structure. Here, I review the current status of cosmological bounds on neutrino properties and discuss the potential of future observations, for example by the recently approved EUCLID mission, to precisely measure neutrino properties....

  17. Cosmology and particle physics

    Energy Technology Data Exchange (ETDEWEB)

    Steigman, G [California Univ., Santa Barbara (USA). Inst. for Theoretical Physics; Bartol Research Foundation, Newark, Delaware (USA))

    1982-01-29

    The cosmic connections between physics on the very largest and very smallest scales are reviewed with an emphasis on the symbiotic relation between elementary particle physics and cosmology. After a review of the early Universe as a cosmic accelerator, various cosmological and astrophysical constraints on models of particle physics are outlined. To illustrate this approach to particle physics via cosmology, reference is made to several areas of current research: baryon non-conservation and baryon asymmetry; free quarks, heavy hadrons and other exotic relics; primordial nucleosynthesis and neutrino masses.

  18. On the Cold Big Bang Cosmology

    Directory of Open Access Journals (Sweden)

    Assis A. V. D. B.

    2011-04-01

    Full Text Available We solve the general relativity (GR field equations under the cosmological scope via one extra postulate. The plausibility of the postulate resides within the Heisenberg indeterminacy principle, being heuristically analysed throughout the appendix. Under this approach, a negative energy density may provide the positive energy content of the universe via fluctuation, since the question of conservation of energy in cosmology is weakened, supported by the known lack of scope of the Noether's theorem in cosmology. The initial condition of the primordial universe turns out to have a natural cutoff such that the temperature of the cosmological substratum converges to the absolute zero, instead of the established divergence at the very beginning. The adopted postulate provides an explanation for the cosmological dark energy open question. The solution agrees with cosmological observations, including a 2.7K CMBT prediction.

  19. Higher dimensional loop quantum cosmology

    International Nuclear Information System (INIS)

    Zhang, Xiangdong

    2016-01-01

    Loop quantum cosmology (LQC) is the symmetric sector of loop quantum gravity. In this paper, we generalize the structure of loop quantum cosmology to the theories with arbitrary spacetime dimensions. The isotropic and homogeneous cosmological model in n + 1 dimensions is quantized by the loop quantization method. Interestingly, we find that the underlying quantum theories are divided into two qualitatively different sectors according to spacetime dimensions. The effective Hamiltonian and modified dynamical equations of n + 1 dimensional LQC are obtained. Moreover, our results indicate that the classical big bang singularity is resolved in arbitrary spacetime dimensions by a quantum bounce. We also briefly discuss the similarities and differences between the n + 1 dimensional model and the 3 + 1 dimensional one. Our model serves as a first example of higher dimensional loop quantum cosmology and offers the possibility to investigate quantum gravity effects in higher dimensional cosmology. (orig.)

  20. Highlights in gravitation and cosmology

    International Nuclear Information System (INIS)

    Iyer, B.R.; Kembhavi, Ajit; Narlikar, J.V.; Vishveshwara, C.V.

    1988-01-01

    This book assesses research into gravitation and cosmology by examining the subject from various viewpoints: the classical and quantum pictures, along with the cosmological and astrophysical applications. There are 35 articles by experts of international standing. Each defines the state of the art and contains a concise summary of our present knowledge of a facet of gravitational physics. These edited papers are based on those first given at an international conference held in Goa, India at the end of 1987. The following broad areas are covered: classical relativity, quantum gravity, cosmology, black holes, compact objects, gravitational radiation and gravity experiments. In this volume there are also summaries of discussions on the following special topics: exact solutions of cosmological equations, mathematical aspects of general relativity, the early universe, and quantum gravity. For research workers in cosmology and gravitation this reference book provides a broad view of present achievements and current problems. (author)

  1. Tay-Sachs disease in Jacob sheep.

    Science.gov (United States)

    Torres, Paola A; Zeng, Bai Jin; Porter, Brian F; Alroy, Joseph; Horak, Fred; Horak, Joan; Kolodny, Edwin H

    2010-12-01

    Autopsy studies of four Jacob sheep dying within their first 6-8 months of a progressive neurodegenerative disorder suggested the presence of a neuronal storage disease. Lysosomal enzyme studies of brain and liver from an affected animal revealed diminished activity of hexosaminidase A (Hex A) measured with an artificial substrate specific for this component of β-hexosaminidase. Absence of Hex A activity was confirmed by cellulose acetate electrophoresis. Brain lipid analyses demonstrated the presence of increased concentrations of G(M2)-ganglioside and asialo-G(M2)-ganglioside. The hexa cDNA of Jacob sheep was cloned and sequenced revealing an identical number of nucleotides and exons as in human HexA and 86% homology in nucleotide sequence. A missense mutation was found in the hexa cDNA of the affected sheep caused by a single nucleotide change at the end of exon 11 resulting in skipping of exon 11. Transfection of normal sheep hexa cDNA into COS1 cells and human Hex A-deficient cells led to expression of Hex S but no increase in Hex A indicating absence of cross-species dimerization of sheep Hex α-subunit with human Hex β-subunits. Using restriction site analysis, the heterozygote frequency of this mutation in Jacob sheep was determined in three geographically separate flocks to average 14%. This large naturally occurring animal model of Tay-Sachs disease is the first to offer promise as a means for trials of gene therapy applicable to human infants. Copyright © 2010 Elsevier Inc. All rights reserved.

  2. New Challenges for Cosmology

    NARCIS (Netherlands)

    van de Weygaert, Rien; van Albada, Tjeerd S.

    1996-01-01

    A detailed account of the ways in which a square kilometer array could further cosmological research. Observational and theoretical studies of the large scale structure and morphology of the local universe are reviewed against the potential capabilities of a new generation telescope. Cosmological

  3. Crystal Structure of Human [Beta]-Hexosaminidase B: Understanding the Molecular Basis of Sandhoff and Tay-Sachs Disease

    Energy Technology Data Exchange (ETDEWEB)

    Mark, Brian L.; Mahuran, Don J.; Cherney, Maia M.; Zhao, Dalian; Knapp, Spencer; James, Michael N.G.

    2010-12-01

    In humans, two major {beta}-hexosaminidase isoenzymes exist: Hex A and Hex B. Hex A is a heterodimer of subunits {alpha} and {beta} (60% identity), whereas Hex B is a homodimer of {beta}-subunits. Interest in human {beta}-hexosaminidase stems from its association with Tay-Sachs and Sandhoff disease; these are prototypical lysosomal storage disorders resulting from the abnormal accumulation of G{sub M2}-ganglioside (G{sub M2}). Hex A degrades G{sub M2} by removing a terminal N-acetyl-D-galactosamine ({beta}-GalNAc) residue, and this activity requires the G{sub M2}-activator, a protein which solubilizes the ganglioside for presentation to Hex A. We present here the crystal structure of human Hex B, alone (2.4 {angstrom}) and in complex with the mechanistic inhibitors GalNAc-isofagomine (2.2 {angstrom}) or NAG-thiazoline (2.5 {angstrom}). From these, and the known X-ray structure of the G{sub M2}-activator, we have modeled Hex A in complex with the activator and ganglioside. Together, our crystallographic and modeling data demonstrate how {alpha} and {beta}-subunits dimerize to form either Hex A or Hex B, how these isoenzymes hydrolyze diverse substrates, and how many documented point mutations cause Sandhoff disease ({beta}-subunit mutations) and Tay-Sachs disease ({alpha}-subunit mutations).

  4. Cosmological phase transitions

    International Nuclear Information System (INIS)

    Kolb, E.W.

    1993-10-01

    If modern ideas about the role of spontaneous symmetry breaking in fundamental physics are correct, then the Universe should have undergone a series of phase transitions early in its history. The study of cosmological phase transitions has become an important aspect of early-Universe cosmology. In this lecture I review some very recent work on three aspects of phase transitions: the electroweak transition, texture, and axions

  5. Area density of localization-entropy II: double cone-localization and quantum origin of the Bondi-Metzner-Sachs symmetry

    Energy Technology Data Exchange (ETDEWEB)

    Schroer, Bert

    2006-04-15

    The holographic encoding is generalized to subalgebras of QFT localized in double cones. It is shown that as a result of this radically different spacetime encoding the modular group acts geometrically on the holographic image. As a result we obtain a formula for localization entropy which is identical to the previously derived formula for the wedge-localized subalgebra. The symmetry group in the holographic encoding turns out to be the Bondi-Metzner-Sachs group. (author)

  6. The Case for a Hierarchical Cosmology

    Science.gov (United States)

    Vaucouleurs, G. de

    1970-01-01

    The development of modern theoretical cosmology is presented and some questionable assumptions of orthodox cosmology are pointed out. Suggests that recent observations indicate that hierarchical clustering is a basic factor in cosmology. The implications of hierarchical models of the universe are considered. Bibliography. (LC)

  7. Cosmological CP Violation

    CERN Document Server

    Tomaschitz, R

    1994-01-01

    Spinor fields are studied in infinite, topologically multiply connected Robertson-Walker cosmologies. Unitary spinor representations for the discrete covering groups of the spacelike slices are constructed. The spectral resolution of Dirac's equation is given in terms of horospherical elementary waves, on which the treatment of spin and energy is based in these cosmologies. The meaning of the energy and the particle-antiparticle concept is explained in the context of this varying cosmic background. Discrete symmetries, in particular inversions of the multiply connected spacelike slices, are studied. The violation of the unitarity of the parity operator, due to self-interference of P-reflected wave packets, is discussed. The violation of the CP and CPT invariance - already on the level of the free Dirac equation on this cosmological background - is pointed out.

  8. Heavy ion collisions and cosmology

    Energy Technology Data Exchange (ETDEWEB)

    Floerchinger, Stefan

    2016-12-15

    There are interesting parallels between the physics of heavy ion collisions and cosmology. Both systems are out-of-equilibrium and relativistic fluid dynamics plays an important role for their theoretical description. From a comparison one can draw interesting conclusions for both sides. For heavy ion physics it could be rewarding to attempt a theoretical description of fluid perturbations similar to cosmological perturbation theory. In the context of late time cosmology, it could be interesting to study dissipative properties such as shear and bulk viscosity and corresponding relaxation times in more detail. Knowledge and experience from heavy ion physics could help to constrain the microscopic properties of dark matter from observational knowledge of the cosmological fluid properties.

  9. Pathological alterations typical of human Tay-Sachs disease, in the retina of a deep-sea fish

    Science.gov (United States)

    Fishelson, L.; Delarea, Yacov; Galil, Bella S.

    Micrographs of retinas from the deep-sea fish Cataetyx laticeps revealed visual cells containing membranous whorls in the ellipsoids of the inner segments resulting from stretching and modifications of the mitochondria membranes and their cristae. These pathological structures seem to be homologous to the whorls observed in retinas of human carriers of Tay-Sachs disease. This disease, a genetic disorder, is found in humans and some mammals. Our findings in fish suggest that the gene responsible can be found throughout the vertebrate evolutionary tree, possibly dormant in most taxa.

  10. Cosmology of a charged universe

    International Nuclear Information System (INIS)

    Barnes, A.

    1979-01-01

    The Proca generalization of electrodynamics admits the possibility that the universe could possess a net electric charge uniformly distributed throughout space, while possessing no electric field. A charged intergalactic (and intragalactic) medium of this kind could contain enough energy to be of cosmological importance. A general-relativistic model of cosmological expansion dominated by such a charged background has been calculated, and is consistent with present observational limits on the Hubble constant, the decleration parameter, and the age of the universe. However, if this cosmology applied at the present epoch, the very early expansion of the universe would have been much more rapid than in conventional ''big bang'' cosmologies, too rapid for cosmological nucleosynthesis or thermalization of the background radiation to have occurred. Hence, domination of the present expansion by background charge appears to be incompatible with the 3 K background and big-bang production of light elements. If the present background charge density were sufficiently small (but not strictly zero), expansion from the epoch of nucleosynthesis would proceed according to the conventional scenario, but the energy due to the background charge would have dominated at some earlier epoch. This last possibility leads to equality of pressure and energy density in the primordial universe, a condition of special significance in certain cosmological theories

  11. On the cosmological problem

    International Nuclear Information System (INIS)

    Heller, M.

    1986-01-01

    It is proposed to understand cosmology as a non-local physics. Non-local methods, when developed from locally performed observations, imply a considerable extrapolation, which in turn is possible without some unverifiable assumptions. Cosmology is, therefore, not only a science on the Universe but also about assumptions that render such a science possible. As far as theoretical aspects of cosmology are concerned, cosmology can be treated as a theory of the space of all solutions to Einstein's field equations (called the ensemble of universes). The very distinction is touched upon between solutions of differential equations, expressing laws of nature, and boundary conditions identifying particular instances of the law's operation. Both observational and theoretical studies demonstrate that our Universe occupies a distinguished position within the ensemble of universes. This fact remains in a close relationship with the existence and developing of structures in the Universe. Possible philosophies aimed at justifying or neutralizing our distinguished situation in the ensemble of universes are discussed at some length. 60 refs. (author)

  12. Conformal Cosmology and Supernova Data

    OpenAIRE

    Behnke, Danilo; Blaschke, David; Pervushin, Victor; Proskurin, Denis

    2000-01-01

    We define the cosmological parameters $H_{c,0}$, $\\Omega_{m,c}$ and $\\Omega_{\\Lambda, c}$ within the Conformal Cosmology as obtained by the homogeneous approximation to the conformal-invariant generalization of Einstein's General Relativity theory. We present the definitions of the age of the universe and of the luminosity distance in the context of this approach. A possible explanation of the recent data from distant supernovae Ia without a cosmological constant is presented.

  13. The several faces of the cosmological principle

    Energy Technology Data Exchange (ETDEWEB)

    Beisbart, Claus [TU Dortmund (Germany). Fakultaet 14, Institut fuer Philosophie und Politikwissenschaft

    2010-07-01

    Much work in relativistic cosmology relies upon the cosmological principle. Very roughly, this principle has it hat the universe is spatially homogeneous and isotropic. However, if the principle is to do some work, it has to be rendered more precise. The aim of this talk is to show that such a precification significantly depends on the theoretical framework adopted and on its ontology. Moreover, it is shown that present-day cosmology uses the principle in different versions that do not fit together nicely. Whereas, in theoretical cosmology, the principle is spelt out as a requirement on space-time manifolds, observational cosmology cashes out the principle using the notion of a random process. I point out some philosophical problems that arise in this context. My conclusion is that the cosmological principle is not a very precise hypothesis, but rather a rough idea that has several faces in contemporary cosmology.

  14. Current observations with a decaying cosmological constant allow for chaotic cyclic cosmology

    International Nuclear Information System (INIS)

    Ellis, George F.R.; Platts, Emma; Weltman, Amanda; Sloan, David

    2016-01-01

    We use the phase plane analysis technique of Madsen and Ellis [1] to consider a universe with a true cosmological constant as well as a cosmological 'constant' that is decaying. Time symmetric dynamics for the inflationary era allows eternally bouncing models to occur. Allowing for scalar field dynamic evolution, we find that if dark energy decays in the future, chaotic cyclic universes exist provided the spatial curvature is positive. This is particularly interesting in light of current observations which do not yet rule out either closed universes or possible evolution of the cosmological constant. We present only a proof of principle, with no definite claim on the physical mechanism required for the present dark energy to decay

  15. Exact solutions in string-motivated scalar-field cosmology

    International Nuclear Information System (INIS)

    Oezer, M.; Taha, M.O.

    1992-01-01

    Two exact cosmological solutions to a scalar-field potential motivated by six-dimensional (6D) Einstein-Maxwell theory are given. The resulting pure scalar-field cosmology is free of singularity and causality problems but conserves entropy. These solutions are then extended into exact cosmological solutions for a decaying scalar field with an approximate two-loop 4D string potential. The resulting cosmology is, for both solutions, free of cosmological problems and close to the standard cosmology of the radiation era

  16. Fractal cosmology

    International Nuclear Information System (INIS)

    Dickau, Jonathan J.

    2009-01-01

    The use of fractals and fractal-like forms to describe or model the universe has had a long and varied history, which begins long before the word fractal was actually coined. Since the introduction of mathematical rigor to the subject of fractals, by Mandelbrot and others, there have been numerous cosmological theories and analyses of astronomical observations which suggest that the universe exhibits fractality or is by nature fractal. In recent years, the term fractal cosmology has come into usage, as a description for those theories and methods of analysis whereby a fractal nature of the cosmos is shown.

  17. Introduction to particle cosmology the standard model of cosmology and its open problems

    CERN Document Server

    Bambi, Cosimo

    2016-01-01

    This book introduces the basic concepts of particle cosmology and covers all the main aspects of the Big Bang Model (expansion of the Universe, Big Bang Nucleosynthesis, Cosmic Microwave Background, large scale structures) and the search for new physics (inflation, baryogenesis, dark matter, dark energy). It also includes the majority of recent discoveries, such as the precise determination of cosmological parameters using experiments like WMAP and Planck, the discovery of the Higgs boson at LHC, the non-discovery to date of supersymmetric particles, and the search for the imprint of gravitational waves on the CMB polarization by Planck and BICEP.   This textbook is based on the authors’ courses on Cosmology, and aims at introducing Particle Cosmology to senior undergraduate and graduate students. It has been especially written to be accessible even for those students who do not have a strong background in General Relativity and quantum field theory. The content of this book is organized in an easy-to-use ...

  18. Newtonian cosmology Newton would understand

    International Nuclear Information System (INIS)

    Lemons, D.S.

    1988-01-01

    Isaac Newton envisioned a static, infinite, and initially uniform, zero field universe that was gravitationally unstable to local condensations of matter. By postulating the existence of such a universe and using it as a boundary condition on Newtonian gravity, a new field equation for gravity is derived, which differs from the classical one by a time-dependent cosmological term proportional to the average mass density of the universe. The new field equation not only makes Jeans' analysis of the gravitational instability of a Newtonian universe consistent, but also gives rise to a family of Newtonian evolutionary cosmologies parametrized by a time-invariant expansion velocity. This Newtonian cosmology contrasts with both 19th-century ones and with post general relativity Newtonian cosmology

  19. Chaos, decoherence and quantum cosmology

    International Nuclear Information System (INIS)

    Calzetta, Esteban

    2012-01-01

    In this topical review we discuss the connections between chaos, decoherence and quantum cosmology. We understand chaos as classical chaos in systems with a finite number of degrees of freedom, decoherence as environment induced decoherence and quantum cosmology as the theory of the Wheeler-DeWitt equation or else the consistent history formulation thereof, first in mini super spaces and later through its extension to midi super spaces. The overall conclusion is that consideration of decoherence is necessary (and probably sufficient) to sustain an interpretation of quantum cosmology based on the wavefunction of the Universe adopting a Wentzel-Kramers-Brillouin form for large Universes, but a definitive account of the semiclassical transition in classically chaotic cosmological models is not available in the literature yet. (topical review)

  20. Beyond the Standard Model of Cosmology

    International Nuclear Information System (INIS)

    Ellis, John; Nanopoulos, D. V.

    2004-01-01

    Recent cosmological observations of unprecented accuracy, by WMAP in particular, have established a 'Standard Model' of cosmology, just as LEP established the Standard Model of particle physics. Both Standard Models raise open questions whose answers are likely to be linked. The most fundamental problems in both particle physics and cosmology will be resolved only within a framework for Quantum Gravity, for which the only game in town is string theory. We discuss novel ways to model cosmological inflation and late acceleration in a non-critical string approach, and discuss possible astrophysical tests

  1. Cosmology and particle physics

    International Nuclear Information System (INIS)

    Barrow, J.D.

    1982-01-01

    A brief overview is given of recent work that integrates cosmology and particle physics. The observational data regarding the abundance of matter and radiation in the Universe is described. The manner in which the cosmological survival density of stable massive particles can be calculated is discussed along with the process of cosmological nucleosynthesis. Several applications of these general arguments are given with reference to the survival density of nucleons, neutrinos and unconfined fractionally charge particles. The use of nucleosynthesis to limit the number of lepton generations is described together with the implications of a small neutrino mass for the origin of galaxies and clusters. (Auth.)

  2. Cosmology for high energy physicists

    International Nuclear Information System (INIS)

    Albrecht, A.

    1987-11-01

    The standard big bang model of cosmology is presented. Although not perfect, its many successes make it a good starting point for most discussions of cosmology. Places are indicated where well understood laboratory physics is incorporated into the big bang, leading to successful predictions. Much less established aspects of high energy physics and some of the new ideas they have introduced into the field of cosmology are discussed, such as string theory, inflation and monopoles. 49 refs., 5 figs

  3. Relic gravitons and viscous cosmologies

    International Nuclear Information System (INIS)

    Cataldo, Mauricio; Mella, Patricio

    2006-01-01

    Previously it was shown that there exists a class of viscous cosmological models which violate the dominant energy condition for a limited amount of time after which they are smoothly connected to the ordinary radiation era (which preserves the dominant energy conditions). This violation of the dominant energy condition at an early cosmological epoch may influence the slopes of energy spectra of relic gravitons that might be of experimental relevance. However, the bulk viscosity coefficient of these cosmologies became negative during the ordinary radiation era, and then the entropy of the sources driving the geometry decreases with time. We show that in the presence of viscous sources with a linear barotropic equation of state p=γρ we get viscous cosmological models with positive bulk viscous stress during all their evolution, and hence the matter entropy increases with the expansion time. In other words, in the framework of viscous cosmologies, there exist isotropic models compatible with the standard second law of thermodynamics which also may influence the slopes of energy spectra of relic gravitons

  4. Weak lensing cosmology beyond ΛCDM

    International Nuclear Information System (INIS)

    Das, Sudeep; Linder, Eric V.; Nakajima, Reiko; Putter, Roland de

    2012-01-01

    Weak gravitational lensing is one of the key probes of the cosmological model, dark energy, and dark matter, providing insight into both the cosmic expansion history and large scale structure growth history. Taking into account a broad spectrum of physics affecting growth — dynamical dark energy, extended gravity, neutrino masses, and spatial curvature — we analyze the cosmological constraints. Similarly we consider the effects of a range of systematic uncertainties, in shear measurement, photometric redshifts, intrinsic alignments, and the nonlinear power spectrum, on cosmological parameter extraction. We also investigate, and provide fitting formulas for, the influence of survey parameters such as redshift depth, galaxy number densities, and sky area on the cosmological constraints in the beyond-ΛCDM parameter space. Finally, we examine the robustness of results for different fiducial cosmologies

  5. Dynamical system approach to running Λ cosmological models

    International Nuclear Information System (INIS)

    Stachowski, Aleksander; Szydlowski, Marek

    2016-01-01

    We study the dynamics of cosmological models with a time dependent cosmological term. We consider five classes of models; two with the non-covariant parametrization of the cosmological term Λ: Λ(H)CDM cosmologies, Λ(a)CDM cosmologies, and three with the covariant parametrization of Λ: Λ(R)CDM cosmologies, where R(t) is the Ricci scalar, Λ(φ)-cosmologies with diffusion, Λ(X)-cosmologies, where X = (1)/(2)g"α"β∇_α∇_βφ is a kinetic part of the density of the scalar field. We also consider the case of an emergent Λ(a) relation obtained from the behaviour of trajectories in a neighbourhood of an invariant submanifold. In the study of the dynamics we used dynamical system methods for investigating how an evolutionary scenario can depend on the choice of special initial conditions. We show that the methods of dynamical systems allow one to investigate all admissible solutions of a running Λ cosmology for all initial conditions. We interpret Alcaniz and Lima's approach as a scaling cosmology. We formulate the idea of an emergent cosmological term derived directly from an approximation of the exact dynamics. We show that some non-covariant parametrization of the cosmological term like Λ(a), Λ(H) gives rise to the non-physical behaviour of trajectories in the phase space. This behaviour disappears if the term Λ(a) is emergent from the covariant parametrization. (orig.)

  6. The Atacama Cosmology Telescope: Cosmological Parameters from the 2008 Power Spectrum

    Science.gov (United States)

    Dunkley, J.; Hlozek, R.; Sievers, J.; Acquaviva, V.; Ade, P. A. R.; Aguirre, P.; Amiri, M.; Appel, J. W.; Barrientos, L. F.; Battistelli, E. S.; hide

    2011-01-01

    We present cosmological parameters derived from the angular power spectrum of the cosmic microwave background (CMB) radiation observed at 148 GHz and 218 GHz over 296 deg(exp 2) with the Atacama Cosmology Telescope (ACT) during its 2008 season. ACT measures fluctuations at scales 500 cosmological parameters from the less contaminated 148 GHz spectrum, marginalizing over SZ and source power. The ACDM cosmological model is a good fit to the data (chi square/dof = 29/46), and ACDM parameters estimated from ACT+Wilkinson Microwave Anisotropy Probe (WMAP) are consistent with the seven-year WMAP limits, with scale invariant n(sub s) = 1 excluded at 99.7% confidence level (CL) (3 sigma). A model with no CMB lensing is disfavored at 2.8 sigma. By measuring the third to seventh acoustic peaks, and probing the Silk damping regime, the ACT data improve limits on cosmological parameters that affect the small-scale CMB power. The ACT data combined with WMAP give a 6 sigma detection of primordial helium, with Y(sub p) = 0.313 +/- 0.044, and a 4 sigma detection of relativistic species, assumed to be neutrinos, with N(sub eff) = 5.3 +/- 1.3 (4.6 +/- 0.8 with BAO+H(sub 0) data). From the CMB alone the running of the spectral index is constrained to be d(sub s) / d ln k = -0,034 +/- 0,018, the limit on the tensor-to-scalar ratio is r < 0,25 (95% CL), and the possible contribution of Nambu cosmic strings to the power spectrum is constrained to string tension G(sub mu) < 1.6 x 10(exp -7) (95% CL),

  7. Quantum cosmology and baby universes

    International Nuclear Information System (INIS)

    Grishchuk, L.P.

    1990-01-01

    The contributed papers presented to the workshop on ''Quantum Cosmology and Baby Universes'' have demonstrated the great interest in, and rapid development of, the field of quantum cosmology. In my view, there are at least three areas of active research at present. The first area can be defined as that of practical calculations. Here researchers are dealing with the basic quantum cosmological equation, which is the Wheeler-DeWitt equation. They try to classify all possible solutions to the Wheeler-DeWitt equation or seek a specific integration contour in order to select one particular wave function or generalize the simple minisuperspace models to more complicated cases, including various inhomogeneities, anisotropies, etc. The second area of research deals with the interpretational issues of quantum cosmology. There are still many questions about how to extract the observational consequences from a given cosmological wave function, the role of time in quantum cosmology, and how to reformulate the rules of quantum mechanics in such a way that they could be applicable to the single system which is our Universe. The third area of research is concerned with the so-called ''third quantization'' of gravity. In this approach a wave function satisfying the Wheeler-DeWitt equation becomes an operator acting on a Wave Function of the many-universes system. Within this approach one operates with Euclidean worm-holes joining different Lorentzian universes. (author)

  8. Effective field theory of cosmological perturbations

    International Nuclear Information System (INIS)

    Piazza, Federico; Vernizzi, Filippo

    2013-01-01

    The effective field theory of cosmological perturbations stems from considering a cosmological background solution as a state displaying spontaneous breaking of time translations and (adiabatic) perturbations as the related Nambu–Goldstone modes. With this insight, one can systematically develop a theory for the cosmological perturbations during inflation and, with minor modifications, also describe in full generality the gravitational interactions of dark energy, which are relevant for late-time cosmology. The formalism displays a unique set of Lagrangian operators containing an increasing number of cosmological perturbations and derivatives. We give an introductory description of the unitary gauge formalism for theories with broken gauge symmetry—that allows us to write down the most general Lagrangian—and of the Stückelberg ‘trick’—that allows to recover gauge invariance and to make the scalar field explicit. We show how to apply this formalism to gravity and cosmology and we reproduce the detailed analysis of the action in the ADM variables. We also review some basic applications to inflation and dark energy. (paper)

  9. Effective field theory of cosmological perturbations

    Science.gov (United States)

    Piazza, Federico; Vernizzi, Filippo

    2013-11-01

    The effective field theory of cosmological perturbations stems from considering a cosmological background solution as a state displaying spontaneous breaking of time translations and (adiabatic) perturbations as the related Nambu-Goldstone modes. With this insight, one can systematically develop a theory for the cosmological perturbations during inflation and, with minor modifications, also describe in full generality the gravitational interactions of dark energy, which are relevant for late-time cosmology. The formalism displays a unique set of Lagrangian operators containing an increasing number of cosmological perturbations and derivatives. We give an introductory description of the unitary gauge formalism for theories with broken gauge symmetry—that allows us to write down the most general Lagrangian—and of the Stückelberg ‘trick’—that allows to recover gauge invariance and to make the scalar field explicit. We show how to apply this formalism to gravity and cosmology and we reproduce the detailed analysis of the action in the ADM variables. We also review some basic applications to inflation and dark energy.

  10. Inflationary phase in Brans-Dicke cosmology with a cosmological constant

    Science.gov (United States)

    Berman, Marcelo Samuel

    1989-12-01

    It has been shown earlier that, for a perfect fluid, a perfect gas law of state, and the Robertson-Walker metric, an exponential phase in Brans-Dicke cosmology is possible, with both positive pressure and density, but not with the violated energy condition p = -ρ. We demonstrate in this paper that the inclusion of a cosmological constant into the theory does not change that picture. Permanent address: Departamento de Ciencias Exatas da Faculdade de Filosofia, Ceincias e Letras da FURJ, Joinville, SC 89200, Brazil.

  11. Thermodynamics in Loop Quantum Cosmology

    International Nuclear Information System (INIS)

    Li, L.F.; Zhu, J.Y.

    2009-01-01

    Loop quantum cosmology (LQC) is very powerful to deal with the behavior of early universe. Moreover, the effective loop quantum cosmology gives a successful description of the universe in the semiclassical region. We consider the apparent horizon of the Friedmann-Robertson-Walker universe as a thermodynamical system and investigate the thermodynamics of LQC in the semiclassical region. The effective density and effective pressure in the modified Friedmann equation from LQC not only determine the evolution of the universe in LQC scenario but also are actually found to be the thermodynamic quantities. This result comes from the energy definition in cosmology (the Misner-Sharp gravitational energy) and is consistent with thermodynamic laws. We prove that within the framework of loop quantum cosmology, the elementary equation of equilibrium thermodynamics is still valid.

  12. The cosmological singularity

    CERN Document Server

    Belinski, Vladimir

    2018-01-01

    Written for researchers focusing on general relativity, supergravity, and cosmology, this is a self-contained exposition of the structure of the cosmological singularity in generic solutions of the Einstein equations, and an up-to-date mathematical derivation of the theory underlying the Belinski–Khalatnikov–Lifshitz (BKL) conjecture on this field. Part I provides a comprehensive review of the theory underlying the BKL conjecture. The generic asymptotic behavior near the cosmological singularity of the gravitational field, and fields describing other kinds of matter, is explained in detail. Part II focuses on the billiard reformulation of the BKL behavior. Taking a general approach, this section does not assume any simplifying symmetry conditions and applies to theories involving a range of matter fields and space-time dimensions, including supergravities. Overall, this book will equip theoretical and mathematical physicists with the theoretical fundamentals of the Big Bang, Big Crunch, Black Hole singula...

  13. Solitons in relativistic cosmologies

    International Nuclear Information System (INIS)

    Pullin, J.

    1988-08-01

    The application to the construction of solitonic cosmologies in General Relativity of the Inverse Scattering Technique of Belinskii an Zakharov is analyzed. Three improvements to the mentioned technique are proposed: the inclusion of higher order poles in the scattering matrix, a new renormalization technique for diagonal metrics and the extension of the technique to include backgrounds with material content by means of a Kaluza-Klein formalism. As a consequence of these improvements, three new aspects can be analyzed: a) The construction of anisotropic and inhomogeneous cosmological models which can mimic the formation of halos and voids, due to the presence of a material content. The new renormalization technique allows to construct an exact perturbation theory. b) The analysis of the dynamics of models with cosmological constant (inflationary models) and their perturbations. c) The study of interaction of gravitational solitonic waves on material backgrounds. Moreover, some additional works, connected with the existance of 'Crack of doom' type singularities in Kaluza-Klein cosmologies, stochastic perturbations in inflationary universes and inflationary phase transitions in rotating universes are described. (Author) [es

  14. Ekpyrotic and cyclic cosmology

    International Nuclear Information System (INIS)

    Lehners, Jean-Luc

    2008-01-01

    Ekpyrotic and cyclic cosmologies provide theories of the very early and of the very late universe. In these models, the big bang is described as a collision of branes - and thus the big bang is not the beginning of time. Before the big bang, there is an ekpyrotic phase with equation of state w=P/(ρ) >>1 (where P is the average pressure and ρ the average energy density) during which the universe slowly contracts. This phase resolves the standard cosmological puzzles and generates a nearly scale-invariant spectrum of cosmological perturbations containing a significant non-Gaussian component. At the same time it produces small-amplitude gravitational waves with a blue spectrum. The dark energy dominating the present-day cosmological evolution is reinterpreted as a small attractive force between our brane and a parallel one. This force eventually induces a new ekpyrotic phase and a new brane collision, leading to the idea of a cyclic universe. This review discusses the detailed properties of these models, their embedding in M-theory and their viability, with an emphasis on open issues and observational signatures

  15. On globally static and stationary cosmologies with or without a cosmological constant and the dark energy problem

    International Nuclear Information System (INIS)

    Buchert, Thomas

    2006-01-01

    In the framework of spatially averaged inhomogeneous cosmologies in classical general relativity, effective Einstein equations govern the regional and the global dynamics of averaged scalar variables of cosmological models. A particular solution may be characterized by a cosmic equation of state. In this paper, it is pointed out that a globally static averaged dust model is conceivable without employing a compensating cosmological constant. Much in the spirit of Einstein's original model we discuss consequences for the global, but also for the regional properties of this cosmology. We then consider the wider class of globally stationary cosmologies that are conceivable in the presented framework. All these models are based on exact solutions of the averaged Einstein equations and provide examples of cosmologies in an out-of-equilibrium state, which we characterize by an information-theoretical measure. It is shown that such cosmologies preserve high-magnitude kinematical fluctuations and so tend to maintain their global properties. The same is true for a Λ-driven cosmos in such a state despite exponential expansion. We outline relations to inflationary scenarios and put the dark energy problem into perspective. Here, it is argued, on the grounds of the discussed cosmologies, that a classical explanation of dark energy through backreaction effects is theoretically conceivable, if the matter-dominated universe emerged from a non-perturbative state in the vicinity of the stationary solution. We also discuss a number of caveats that furnish strong counter arguments in the framework of structure formation in a perturbed Friedmannian model

  16. Three novel mutations in Iranian patients with Tay-Sachs disease.

    Science.gov (United States)

    Jamali, Solmaz; Eskandari, Nasim; Aryani, Omid; Salehpour, Shadab; Zaman, Talieh; Kamalidehghan, Behnam; Houshmand, Massoud

    2014-01-01

    Tay-Sachs disease (TSD), or GM2 gangliosidosis, is a lethal autosomal recessive neurodegenerative disorder, which is caused by a deficiency of beta-hexosaminidase A (HEXA), resulting in lysosomal accumulation of GM2 ganglioside. The aim of this study was to identify the TSD-causing mutations in an Iranian population. In this study, we examined 31 patients for TSD-causing mutations using PCR, followed by restriction enzyme digestion. Molecular genetics analysis of DNA from 23 patients of TSD revealed mutations that has been previously reported, including four-base duplications c.1274_1277dupTATC in exon 11 and IVS2+1G>A, deletion TTAGGCAAGGGC in exon 10 as well as a few novel mutations, including C331G, which altered Gln>Glu in HEXB, A>G, T>C, and p.R510X in exon 14, which predicted a termination codon or nonsense mutation. In conclusion, with the discovery of these novel mutations, the genotypic spectrum of Iranian patients with TSD disease has been extended and could facilitate definition of disease-related mutations.

  17. Probing modifications of general relativity using current cosmological observations

    International Nuclear Information System (INIS)

    Zhao Gongbo; Bacon, David J.; Koyama, Kazuya; Nichol, Robert C.; Song, Yong-Seon; Giannantonio, Tommaso; Pogosian, Levon; Silvestri, Alessandra

    2010-01-01

    We test general relativity (GR) using current cosmological data: the CMB from WMAP5 [E. Komatsu et al. (WMAP Collaboration), Astrophys. J. Suppl. Ser. 180, 330 (2009)], the integrated Sachs-Wolfe (ISW) effect from the cross correlation of the CMB with six galaxy catalogs [T. Giannantonio et al., Phys. Rev. D 77, 123520 (2008)], a compilation of supernovae (SNe) type Ia including the latest Sloan Digital Sky Survey SNe [R. Kessler et al., Astrophys. J. Suppl. Ser. 185, 32 (2009).], and part of the weak lensing (WL) data from the Canada-Franco-Hawaii Telescope Legacy Survey [L. Fu et al., Astron. Astrophys. 479, 9 (2008); M. Kilbinger et al., Astron. Astrophys. 497, 677 (2009).] that probe linear and mildly nonlinear scales. We first test a model in which the effective Newtonian constant μ and the ratio of the two gravitational potentials, η, transit from the GR value to another constant at late times; in this case, we find that GR is fully consistent with the combined data. The strongest constraint comes from the ISW effect which would arise from this gravitational transition; the observed ISW signal imposes a tight constraint on a combination of μ and η that characterizes the lensing potential. Next, we consider four pixels in time and space for each function μ and η, and perform a principal component analysis, finding that seven of the resulting eight eigenmodes are consistent with GR within the errors. Only one eigenmode shows a 2σ deviation from the GR prediction, which is likely to be due to a systematic effect. However, the detection of such a deviation demonstrates the power of our time- and scale-dependent principal component analysis methodology when combining observations of structure formation and expansion history to test GR.

  18. Cosmological models in energy-momentum-squared gravity

    Science.gov (United States)

    Board, Charles V. R.; Barrow, John D.

    2017-12-01

    We study the cosmological effects of adding terms of higher order in the usual energy-momentum tensor to the matter Lagrangian of general relativity. This is in contrast to most studies of higher-order gravity which focus on generalizing the Einstein-Hilbert curvature contribution to the Lagrangian. The resulting cosmological theories give rise to field equations of similar form to several particular theories with different fundamental bases, including bulk viscous cosmology, loop quantum gravity, k -essence, and brane-world cosmologies. We find a range of exact solutions for isotropic universes, discuss their behaviors with reference to the early- and late-time evolution, accelerated expansion, and the occurrence or avoidance of singularities. We briefly discuss extensions to anisotropic cosmologies and delineate the situations where the higher-order matter terms will dominate over anisotropies on approach to cosmological singularities.

  19. Particle physics and cosmology

    International Nuclear Information System (INIS)

    Ellis, J.; Nanopoulos, D.

    1983-01-01

    The authors describe the connection between cosmology and particle physics in an introductory way. In this connection the big bang theory and unified gauge models of strong, electromagnetic, and weak interactions are considered. Furthermore cosmological nucleosynthesis is discussed in this framework, and the problem of cosmic neutrinos is considered with special regards to its rest mass. (HSI).

  20. The encyclopedia of cosmology

    CERN Document Server

    Barkana, Rennan; Tsujikawa, Shinji; Kim, Jihn E; Nagamine, Kentaro

    2018-01-01

    The Encyclopedia of Cosmology, in four volumes, is a major, long-lasting, seminal reference at the graduate student level, laid out by the most prominent, respected researchers in the general field of Cosmology. These volumes will be a comprehensive review of the most important concepts and current status in the field, covering both theory and observation.

  1. Identification of two HEXA mutations causing infantile-onset Tay-Sachs disease in the Persian population.

    Science.gov (United States)

    Haghighi, Alireza; Rezazadeh, Jamileh; Shadmehri, Azam Ahmadi; Haghighi, Amirreza; Kornreich, Ruth; Desnick, Robert J

    2011-09-01

    The β-hexosaminidase A (HEXA) mutations in the first reported cases of infantile Tay-Sachs disease in the Persian population were identified in two unrelated consanguineous families. The clinical diagnoses of the affected infants were confirmed by their markedly deficient levels of HEXA activity in plasma or peripheral leukocytes. The specific causative mutation in each family was determined by sequencing the HEXA alleles in both sets of related parents. Two mutations were identified: c.1A>G (p.MIV), which obliterated the initiating methionine in codon 1, and c.1177C>T (p.R393X), which predicted a termination codon or nonsense mutation.

  2. Cosmological tests of modified gravity.

    Science.gov (United States)

    Koyama, Kazuya

    2016-04-01

    We review recent progress in the construction of modified gravity models as alternatives to dark energy as well as the development of cosmological tests of gravity. Einstein's theory of general relativity (GR) has been tested accurately within the local universe i.e. the Solar System, but this leaves the possibility open that it is not a good description of gravity at the largest scales in the Universe. This being said, the standard model of cosmology assumes GR on all scales. In 1998, astronomers made the surprising discovery that the expansion of the Universe is accelerating, not slowing down. This late-time acceleration of the Universe has become the most challenging problem in theoretical physics. Within the framework of GR, the acceleration would originate from an unknown dark energy. Alternatively, it could be that there is no dark energy and GR itself is in error on cosmological scales. In this review, we first give an overview of recent developments in modified gravity theories including f(R) gravity, braneworld gravity, Horndeski theory and massive/bigravity theory. We then focus on common properties these models share, such as screening mechanisms they use to evade the stringent Solar System tests. Once armed with a theoretical knowledge of modified gravity models, we move on to discuss how we can test modifications of gravity on cosmological scales. We present tests of gravity using linear cosmological perturbations and review the latest constraints on deviations from the standard [Formula: see text]CDM model. Since screening mechanisms leave distinct signatures in the non-linear structure formation, we also review novel astrophysical tests of gravity using clusters, dwarf galaxies and stars. The last decade has seen a number of new constraints placed on gravity from astrophysical to cosmological scales. Thanks to on-going and future surveys, cosmological tests of gravity will enjoy another, possibly even more, exciting ten years.

  3. From Mateev's baryogenesis ideas to contemporary cosmological constraints

    International Nuclear Information System (INIS)

    Kirilova, D.

    2011-01-01

    Mateev's ideas on baryogenesis and the possibility to constrain new physics on the basis of cosmological observations present the first impulse for the development of the physical cosmology and astroparticle physics in Bulgaria. Contemporary cosmological models of baryogenesis, leptogenesis, primordial nucleosynthesis and cosmological constraints on new physics are discussed

  4. Cosmology and unified gauge theory

    Science.gov (United States)

    Oraifeartaigh, L.

    1981-09-01

    Theoretical points in common between cosmology and unified gauge theory (UGT) are reviewed, with attention given to areas of one which have proven useful for the other. The underlying principles for both theoretical frameworks are described, noting the differences in scale, i.e., 10 to the 25th cm in cosmology and 10 to the -15th cm for UGT. Cosmology has produced bounds on the number of existing neutrino species, and also on the mass of neutrinos, two factors of interest in particle physics. Electrons, protons, and neutrinos, having been spawned from the same massive leptons, each composed of three quarks, have been predicted to be present in equal numbers in the Universe by UGT, in line with necessities of cosmology. The Grand UGT also suggests specific time scales for proton decay, thus accounting for the observed baryon assymmetry.

  5. Dissipative Boltzmann-Robertson-Walker cosmologies

    International Nuclear Information System (INIS)

    Hiscock, W.A.; Salmonson, J.

    1991-01-01

    The equations governing a flat Robertson-Walker cosmological model containing a dissipative Boltzmann gas are integrated numerically. The bulk viscous stress is modeled using the Eckart and Israel-Stewart theories of dissipative relativistic fluids; the resulting cosmologies are compared and contrasted. The Eckart models are shown to always differ in a significant quantitative way from the Israel-Stewart models. It thus appears inappropriate to use the pathological (nonhyperbolic) Eckart theory for cosmological applications. For large bulk viscosities, both cosmological models approach asymptotic nonequilibrium states; in the Eckart model the total pressure is negative, while in the Israel-Stewart model the total pressure is asymptotically zero. The Eckart model also expands more rapidly than the Israel-Stewart models. These results suggest that ''bulk-viscous'' inflation may be an artifact of using a pathological fluid theory such as the Eckart theory

  6. On the Cold Big Bang Cosmology

    Directory of Open Access Journals (Sweden)

    Assis A. V. D. B.

    2011-04-01

    Full Text Available We solve the general relativity (GR field equations under the cosmological scope via one extra postulate. The plausibility of the postulate resides within the Heisenberg in- determinacy principle, being heuristically analysed throughout the appendix. Under this approach, a negative energy density may provide the positive energy content of the universe via fluctuation, since the question of conservation of energy in cosmol- ogy is weakened, supported by the known lack of scope of the Noether’s theorem in cosmology. The initial condition of the primordial universe turns out to have a natural cuto such that the temperature of the cosmological substratum converges to the ab- solute zero, instead of the established divergence at the very beginning. The adopted postulate provides an explanation for the cosmological dark energy open question. The solution agrees with cosmological observations, including a 2.7K CMBT prediction.

  7. Black hole versus cosmological horizon entropy

    International Nuclear Information System (INIS)

    Davis, Tamara M; Davies, P C W; Lineweaver, Charles H

    2003-01-01

    The generalized second law of thermodynamics states that entropy always increases when all event horizons are attributed with an entropy proportional to their area. We test the generalized second law by investigating the change in entropy when dust, radiation and black holes cross a cosmological event horizon. We generalize for flat, open and closed Friedmann-Robertson-Walker universes by using numerical calculations to determine the cosmological horizon evolution. In most cases, the loss of entropy from within the cosmological horizon is more than balanced by an increase in cosmological event horizon entropy, maintaining the validity of the generalized second law of thermodynamics. However, an intriguing set of open universe models shows an apparent entropy decrease when black holes disappear over the cosmological event horizon. We anticipate that this apparent violation of the generalized second law will disappear when solutions are available for black holes embedded in arbitrary backgrounds

  8. Landscape predictions from cosmological vacuum selection

    Energy Technology Data Exchange (ETDEWEB)

    Bousso, Raphael; Bousso, Raphael; Yang, Sheng

    2007-04-23

    In Bousso-Polchinski models with hundreds of fluxes, we compute the effects of cosmological dynamics on the probability distribution of landscape vacua. Starting from generic initial conditions, we find that most fluxes are dynamically driven into a different and much narrower range of values than expected from landscape statistics alone. Hence, cosmological evolution will access only a tiny fraction of the vacua with small cosmological constant. This leads to a host of sharp predictions. Unlike other approaches to eternal inflation, the holographic measure employed here does not lead to staggering, an excessive spread of probabilities that would doom the string landscape as a solution to the cosmological constant problem.

  9. Landscape predictions from cosmological vacuum selection

    International Nuclear Information System (INIS)

    Bousso, Raphael; Yang, I-S.

    2007-01-01

    In Bousso-Polchinski models with hundreds of fluxes, we compute the effects of cosmological dynamics on the probability distribution of landscape vacua. Starting from generic initial conditions, we find that most fluxes are dynamically driven into a different and much narrower range of values than expected from landscape statistics alone. Hence, cosmological evolution will access only a tiny fraction of the vacua with small cosmological constant. This leads to a host of sharp predictions. Unlike other approaches to eternal inflation, the holographic measure employed here does not lead to staggering, an excessive spread of probabilities that would doom the string landscape as a solution to the cosmological constant problem

  10. Cosmological string solutions by dimensional reduction

    International Nuclear Information System (INIS)

    Behrndt, K.; Foerste, S.

    1993-12-01

    We obtain cosmological four dimensional solutions of the low energy effective string theory by reducing a five dimensional black hole, and black hole-de Sitter solution of the Einstein gravity down to four dimensions. The appearance of a cosmological constant in the five dimensional Einstein-Hilbert produces a special dilaton potential in the four dimensional effective string action. Cosmological scenarios implement by our solutions are discussed

  11. Elements of the universe in Philo’s De Vita Mosis: Cosmological theology or theological cosmology?

    Directory of Open Access Journals (Sweden)

    Gert J. Steyn

    2013-11-01

    Full Text Available It is the intention of this article to investigate how Philo’s understanding of the universe, and particularly its four basic elements as taught by the Greek philosophers, influenced his description of the God of Israel’s world in which the Moses narrative unfolds. Given the fact that Philo was a theologian par excellence, the question can be asked whether Philo’s approach is closer to what one might call ‘theological cosmology’ or rather closer to ‘cosmological theology’? After a brief survey of Philo’s inclination to interpret Jewish history in the light of Greek cosmology, the study proceeds with his universe as symbolised in the high priest’s vestments. The τετρακτύςwith its 10 points of harmony is a key to Philo’s symbolism and numerology. The article concludes that Philo is not writing cosmology per se in his De Vita Mosis, but he is rather writing a theology that sketches the cosmic superiority and involvement of Israel’s God against the backdrop of Greek cosmology as it was influenced by Pythagoras’ geometry and numerology as well as by Plato’s philosophy. In this sense his account in the De Vita Mosisis closer to a cosmological theology. He utilises the cosmological picture of the Greco-Hellenistic world in order to introduce and present the powerful nature and qualities of Israel’s God.

  12. Zero cosmological constant from normalized general relativity

    International Nuclear Information System (INIS)

    Davidson, Aharon; Rubin, Shimon

    2009-01-01

    Normalizing the Einstein-Hilbert action by the volume functional makes the theory invariant under constant shifts in the Lagrangian. The associated field equations then resemble unimodular gravity whose otherwise arbitrary cosmological constant is now determined as a Machian universal average. We prove that an empty space-time is necessarily Ricci tensor flat, and demonstrate the vanishing of the cosmological constant within the scalar field paradigm. The cosmological analysis, carried out at the mini-superspace level, reveals a vanishing cosmological constant for a universe which cannot be closed as long as gravity is attractive. Finally, we give an example of a normalized theory of gravity which does give rise to a non-zero cosmological constant.

  13. Astroparticle physics and cosmology

    International Nuclear Information System (INIS)

    Senjanovic, G.; Smirnov, A.Yu.; Thompson, G.

    2001-01-01

    In this volume a wide spectrum of topics of modern astroparticle physics, such as neutrino astrophysics, dark matter of the universe, high energy cosmic rays, topological defects in cosmology, γ-ray bursts, phase transitions at high temperatures, is covered. The articles written by top level experts in the field give a comprehensive view of the state-of-the-art of modern cosmology

  14. Astroparticle physics and cosmology

    Energy Technology Data Exchange (ETDEWEB)

    Senjanovic, G; Smirnov, A Yu; Thompson, G [eds.

    2001-11-15

    In this volume a wide spectrum of topics of modern astroparticle physics, such as neutrino astrophysics, dark matter of the universe, high energy cosmic rays, topological defects in cosmology, {gamma}-ray bursts, phase transitions at high temperatures, is covered. The articles written by top level experts in the field give a comprehensive view of the state-of-the-art of modern cosmology.

  15. A null test of the cosmological constant

    International Nuclear Information System (INIS)

    Chiba, Takeshi; Nakamura, Takashi

    2007-01-01

    We provide a consistency relation between cosmological observables in general relativity with the cosmological constant. Breaking of this relation at any redshift would imply the breakdown of the hypothesis of the cosmological constant as an explanation of the current acceleration of the universe. (author)

  16. Horizons of cosmology

    CERN Document Server

    Silk, Joseph

    2011-01-01

    Horizons of Cosmology: Exploring Worlds Seen and Unseen is the fourth title published in the Templeton Science and Religion Series, in which scientists from a wide range of fields distill their experience and knowledge into brief tours of their respective specialties. In this volume, highly esteemed astrophysicist Joseph Silk explores the vast mysteries and speculations of the field of cosmology in a way that balances an accessible style for the general reader and enough technical detail for advanced students and professionals. Indeed, while the p

  17. Neutrino physics and precision cosmology

    DEFF Research Database (Denmark)

    Hannestad, Steen

    2016-01-01

    I review the current status of structure formation bounds on neutrino properties such as mass and energy density. I also discuss future cosmological bounds as well as a variety of different scenarios for reconciling cosmology with the presence of light sterile neutrinos....

  18. Bianchi type II brane-world cosmologies (U≥0)

    International Nuclear Information System (INIS)

    Hoogen, R.J. van den; Ibanez, J.

    2003-01-01

    The asymptotic properties of the Bianchi type II cosmological model in the brane-world scenario are investigated. The matter content is assumed to be a combination of a perfect fluid and a minimally coupled scalar field that is restricted to the brane. The isotropic brane-world solution is determined to represent the initial singularity in all brane-world cosmologies. Additionally, it is shown that it is the kinetic energy of the scalar field which dominates the initial dynamics in these brane-world cosmologies. It is important to note that the dynamics of these brane-world cosmologies is not necessarily asymptotic to general relativistic cosmologies to the future in the case of a zero four-dimensional cosmological constant

  19. Physical and Relativistic Numerical Cosmology.

    Science.gov (United States)

    Anninos, Peter

    1998-01-01

    In order to account for the observable Universe, any comprehensive theory or model of cosmology must draw from many disciplines of physics, including gauge theories of strong and weak interactions, the hydrodynamics and microphysics of baryonic matter, electromagnetic fields, and spacetime curvature, for example. Although it is difficult to incorporate all these physical elements into a single complete model of our Universe, advances in computing methods and technologies have contributed significantly towards our understanding of cosmological models, the Universe, and astrophysical processes within them. A sample of numerical calculations addressing specific issues in cosmology are reviewed in this article: from the Big Bang singularity dynamics to the fundamental interactions of gravitational waves; from the quark-hadron phase transition to the large scale structure of the Universe. The emphasis, although not exclusively, is on those calculations designed to test different models of cosmology against the observed Universe.

  20. Physical and Relativistic Numerical Cosmology

    Directory of Open Access Journals (Sweden)

    Peter Anninos

    1998-01-01

    Full Text Available In order to account for the observable Universe, any comprehensive theory or model of cosmology must draw from many disciplines of physics, including gauge theories of strong and weak interactions, the hydrodynamics and microphysics of baryonic matter, electromagnetic fields, and spacetime curvature, for example. Although it is difficult to incorporate all these physical elements into a single complete model of our Universe, advances in computing methods and technologies have contributed significantly towards our understanding of cosmological models, the Universe, and astrophysical processes within them. A sample of numerical calculations addressing specific issues in cosmology are reviewed in this article: from the Big Bang singularity dynamics to the fundamental interactions of gravitational waves; from the quark--hadron phase transition to the large scale structure of the Universe. The emphasis, although not exclusively, is on those calculations designed to test different models of cosmology against the observed Universe.

  1. Bimetric gravity is cosmologically viable

    Directory of Open Access Journals (Sweden)

    Yashar Akrami

    2015-09-01

    Full Text Available Bimetric theory describes gravitational interactions in the presence of an extra spin-2 field. Previous work has suggested that its cosmological solutions are generically plagued by instabilities. We show that by taking the Planck mass for the second metric, Mf, to be small, these instabilities can be pushed back to unobservably early times. In this limit, the theory approaches general relativity with an effective cosmological constant which is, remarkably, determined by the spin-2 interaction scale. This provides a late-time expansion history which is extremely close to ΛCDM, but with a technically-natural value for the cosmological constant. We find Mf should be no larger than the electroweak scale in order for cosmological perturbations to be stable by big-bang nucleosynthesis. We further show that in this limit the helicity-0 mode is no longer strongly-coupled at low energy scales.

  2. Particle physics and cosmology, Task C

    International Nuclear Information System (INIS)

    Turner, M.S.

    1993-05-01

    The research has spanned many topics at the boundary of particle physics and cosmology. The major focus has been in the general areas of inflationary cosmology, cosmological phase transitions, astrophysical constraints to particle physics theories, and dark matter/structure formation as it relates to particle physics. Some attention is given to axion physics. Narrative summaries of the research of the individual group members are given, followed by a list of publications

  3. Traumatic glenohumeral bone defects and their relationship to failure of arthroscopic Bankart repairs: significance of the inverted-pear glenoid and the humeral engaging Hill-Sachs lesion.

    Science.gov (United States)

    Burkhart, S S; De Beer, J F

    2000-10-01

    Our goal was to analyze the results of 194 consecutive arthroscopic Bankart repairs (performed by 2 surgeons with an identical suture anchor technique) in order to identify specific factors related to recurrence of instability. Case series. We analyzed 194 consecutive arthroscopic Bankart repairs by suture anchor technique performed for traumatic anterior-inferior instability. The average follow-up was 27 months (range, 14 to 79 months). There were 101 contact athletes (96 South African rugby players and 5 American football players). We identified significant bone defects on either the humerus or the glenoid as (1) "inverted-pear" glenoid, in which the normally pear-shaped glenoid had lost enough anterior-inferior bone to assume the shape of an inverted pear; or (2) "engaging" Hill-Sachs lesion of the humerus, in which the orientation of the Hill-Sachs lesion was such that it engaged the anterior glenoid with the shoulder in abduction and external rotation. There were 21 recurrent dislocations and subluxations (14 dislocations, 7 subluxations). Of those 21 shoulders with recurrent instability, 14 had significant bone defects (3 engaging Hill-Sachs and 11 inverted-pear Bankart lesions). For the group of patients without significant bone defects (173 shoulders), there were 7 recurrences (4% recurrence rate). For the group with significant bone defects (21 patients), there were 14 recurrences (67% recurrence rate). For contact athletes without significant bone defects, there was a 6.5% recurrence rate, whereas for contact athletes with significant bone defects, there was an 89% recurrence rate. (1) Arthroscopic Bankart repairs give results equal to open Bankart repairs if there are no significant structural bone deficits (engaging Hill-Sachs or inverted-pear Bankart lesions). (2) Patients with significant bone deficits as defined in this study are not candidates for arthroscopic Bankart repair. (3) Contact athletes without structural bone deficits may be treated by

  4. Modified geodetic brane cosmology

    International Nuclear Information System (INIS)

    Cordero, Rubén; Cruz, Miguel; Molgado, Alberto; Rojas, Efraín

    2012-01-01

    We explore the cosmological implications provided by the geodetic brane gravity action corrected by an extrinsic curvature brane term, describing a codimension-1 brane embedded in a 5D fixed Minkowski spacetime. In the geodetic brane gravity action, we accommodate the correction term through a linear term in the extrinsic curvature swept out by the brane. We study the resulting geodetic-type equation of motion. Within a Friedmann–Robertson–Walker metric, we obtain a generalized Friedmann equation describing the associated cosmological evolution. We observe that, when the radiation-like energy contribution from the extra dimension is vanishing, this effective model leads to a self-(non-self)-accelerated expansion of the brane-like universe in dependence on the nature of the concomitant parameter β associated with the correction, which resembles an analogous behaviour in the DGP brane cosmology. Several possibilities in the description for the cosmic evolution of this model are embodied and characterized by the involved density parameters related in turn to the cosmological constant, the geometry characterizing the model, the introduced β parameter as well as the dark-like energy and the matter content on the brane. (paper)

  5. Observational cosmology

    International Nuclear Information System (INIS)

    Partridge, R.B.

    1977-01-01

    Some sixty years after the development of relativistic cosmology by Einstein and his colleagues, observations are finally beginning to have an important impact on our views of the Universe. The available evidence seems to support one of the simplest cosmological models, the hot Big Bang model. The aim of this paper is to assess the observational support for certain assumptions underlying the hot Big Bang model. These are that the Universe is isobaric and homogeneous on a large scale; that it is expanding from an initial state of high density and temperature; and that the proper theory to describe the dynamics of the Universe is unmodified General Relativity. The properties of the cosmic microwave background radiation and recent observations of the abundance of light elements, in particular, support these assumptions. Also examined here are the data bearing on the related questions of the geometry and the future of the Universe (is it ever-expanding, or fated to recollapse). Finally, some difficulties and faults of the standard model are discussed, particularly various aspects of the 'initial condition' problem. It appears that the simplest Big Bang cosmological model calls for a highly specific set of initial conditions to produce the presently observed properties of the Universe. (Auth.)

  6. Improved standard cosmology: Comparison with observation

    International Nuclear Information System (INIS)

    Wesson, P.S.

    1982-01-01

    A cosmological model describing inhomogeneous clusters of galaxies embedded in a homogeneous background is compared to observation. In this model, a cluster is described as a spherically symmetric distribution of matter with an inverse-square density law and an isothermal equation of state, while the background universe is essentially the Einstein/de Sitter one of standard cosmology, but with a small pressure. The model is found to be in overall good agreement with observation, and its adjustable parameters are assigned numerical values. The equation of state for a cluster and the finite cosmological pressure are properties of the model which can in principle be investigated by carrying out observations. Subject headings: cosmology: galaxies: clusters of: relativity

  7. The cosmology of the Fab-Four

    International Nuclear Information System (INIS)

    Copeland, Edmund J.; Padilla, Antonio; Saffin, Paul M.

    2012-01-01

    We have recently proposed a novel self tuning mechanism to alleviate the famous cosmological constant problem, based on the general scalar tensor theory proposed by Horndeski. The self-tuning model ends up consisting of four geometric terms in the action, with each term containing a free potential function of the scalar field; the four together being labeled as the Fab-Four. In this paper we begin the important task of deriving the cosmology associated with the Fab-Four Lagrangian. Performing a phase plane analysis of the system we are able to obtain a number of fixed points for the system, with some remarkable new solutions emerging from the trade-off between the various potentials. As well as obtaining inflationary solutions we also find conventional radiation/matter-like solutions, but in regimes where the energy density is dominated by a cosmological constant, and where we do not have any explicit forms of radiation or matter. Stability conditions for matter solutions are obtained and we show how it is possible for there to exist an extended period of 'matter domination' opening up the possibility that we can generate cosmological structures, and recover a consistent cosmology even in the presence of a large cosmological constant

  8. Cosmologies of the ancient Mediterranean world

    Directory of Open Access Journals (Sweden)

    John T. Fitzgerald

    2013-07-01

    Full Text Available Cosmology is concerned with the order of the universe and seeks to provide an account, not only of that order, but also of the mind or reason behind it. In antiquity, the cosmos was usually understood religiously, such that the cosmologies of the ancient Mediterranean world were either religious in nature or constituted a reaction to a religiously conceived understanding of the structures of the universe. The oldest form in which ancient cosmologies occur is myth, which, owing to its elasticity as a form, enabled them to be appropriated, adapted and used by different groups. In addition, different cosmologies co-existed within the same ancient culture, each having an authoritative status. This article provides an introductory overview of these cosmological myths and argues that a comparative approach is the most fruitful way to study them. Emphasis is given to certain prominent cosmological topics, including theogony (the genesis of the divine or the relationship of the divine to the cosmos, cosmogony (the genesis of the cosmos, and anthropogony (the origin of humans within the cosmos. Although these myths vary greatly in terms of content and how they envision the origin of the cosmos, many of them depict death as part of the structure of the universe.

  9. Quantum cosmology and late-time singularities

    International Nuclear Information System (INIS)

    Kamenshchik, A Yu

    2013-01-01

    The development of dark energy models has stimulated interest to cosmological singularities, which differ from the traditional Big Bang and Big Crunch singularities. We review a broad class of phenomena connected with soft cosmological singularities in classical and quantum cosmology. We discuss the classification of singularities from the geometrical point of view and from the point of view of the behavior of finite size objects, crossing such singularities. We discuss in some detail quantum and classical cosmology of models based on perfect fluids (anti-Chaplygin gas and anti-Chaplygin gas plus dust), of models based on the Born–Infeld-type fields and of the model of a scalar field with a potential inversely proportional to the field itself. We dwell also on the phenomenon of the phantom divide line crossing in the scalar field models with cusped potentials. Then we discuss the Friedmann equations modified by quantum corrections to the effective action of the models under considerations and the influence of such modification on the nature and the existence of soft singularities. We review also quantum cosmology of models, where the initial quantum state of the universe is presented by the density matrix (mixed state). Finally, we discuss the exotic singularities arising in the braneworld cosmological models. (topical review)

  10. Cosmic curvature from de Sitter equilibrium cosmology.

    Science.gov (United States)

    Albrecht, Andreas

    2011-10-07

    I show that the de Sitter equilibrium cosmology generically predicts observable levels of curvature in the Universe today. The predicted value of the curvature, Ω(k), depends only on the ratio of the density of nonrelativistic matter to cosmological constant density ρ(m)(0)/ρ(Λ) and the value of the curvature from the initial bubble that starts the inflation, Ω(k)(B). The result is independent of the scale of inflation, the shape of the potential during inflation, and many other details of the cosmology. Future cosmological measurements of ρ(m)(0)/ρ(Λ) and Ω(k) will open up a window on the very beginning of our Universe and offer an opportunity to support or falsify the de Sitter equilibrium cosmology.

  11. Cosmology and the weak interaction

    International Nuclear Information System (INIS)

    Schramm, D.N.

    1989-12-01

    The weak interaction plays a critical role in modern Big Bang cosmology. This review will emphasize two of its most publicized cosmological connections: Big Bang nucleosynthesis and Dark Matter. The first of these is connected to the cosmological prediction of Neutrino Flavours, N ν ∼ 3 which is now being confirmed at SLC and LEP. The second is interrelated to the whole problem of galaxy and structure formation in the universe. This review will demonstrate the role of the weak interaction both for dark matter candidates and for the problem of generating seeds to form structure. 87 refs., 3 figs., 5 tabs

  12. Cosmology and the weak interaction

    Energy Technology Data Exchange (ETDEWEB)

    Schramm, D.N. (Fermi National Accelerator Lab., Batavia, IL (USA)):(Chicago Univ., IL (USA))

    1989-12-01

    The weak interaction plays a critical role in modern Big Bang cosmology. This review will emphasize two of its most publicized cosmological connections: Big Bang nucleosynthesis and Dark Matter. The first of these is connected to the cosmological prediction of Neutrino Flavours, N{sub {nu}} {approximately} 3 which is now being confirmed at SLC and LEP. The second is interrelated to the whole problem of galaxy and structure formation in the universe. This review will demonstrate the role of the weak interaction both for dark matter candidates and for the problem of generating seeds to form structure. 87 refs., 3 figs., 5 tabs.

  13. Generation of HEXA-deficient hiPSCs from fibroblasts of a Tay-Sachs disease patient

    Directory of Open Access Journals (Sweden)

    Zhong Liu

    2016-09-01

    Full Text Available Human iPSC line TSD-01-hiPSC was generated from fibroblasts of a patient with infantile Tay-Sachs disease (TSD. The patient is compound heterozygous at the HEXA gene by carrying a 1278insTATC allele and an IVS12+1G>C allele. STEMCCA lentivirus, which expresses OCT4, SOX2, KLF4, and c-MYC from a polycistronic transcript, were used for reprogramming. TSD-01-hiPSC express pluripotency markers such as OCT4, SOX2, NANOG, Tra-1-60, and alkaline phosphatase, and can differentiate into tissues from all the three embryonic germ layers. This TSD patient-derived hiPSC line may serve as a valuable in vitro tool for disease modeling and drug test.

  14. Adventures in cosmology

    CERN Document Server

    2012-01-01

    This volume tells of the quest for cosmology as seen by some of the finest cosmologists in the world. It starts with "Galaxy Formation from Start to Finish" and ends with "The First Supermassive Black Holes in the Universe," exploring in between the grand themes of galaxies, the early universe, expansion of the universe, dark matter and dark energy. This up-to-date collection of review articles offers a general introduction to cosmology and is intended for all probing into the profound questions on where we came from and where we are going.

  15. Relativistic Cosmology Revisited

    Directory of Open Access Journals (Sweden)

    Crothers S. J.

    2007-04-01

    Full Text Available In a previous paper the writer treated of particular classes of cosmological solutions for certain Einstein spaces and claimed that no such solutions exist in relation thereto. In that paper the assumption that the proper radius is zero when the line-element is singular was generally applied. This general assumption is unjustified and must be dropped. Consequently, solutions do exist in relation to the aforementioned types, and are explored herein. The concept of the Big Bang cosmology is found to be inconsistent with General Relativity

  16. Cosmological reconstruction of realistic modified F(R) gravities

    International Nuclear Information System (INIS)

    Nojiri, Shin'ichi; Odintsov, Sergei D.; Saez-Gomez, Diego

    2009-01-01

    The cosmological reconstruction scheme for modified F(R) gravity is developed in terms of e-folding (or, redshift). It is demonstrated how any FRW cosmology may emerge from specific F(R) theory. The specific examples of well-known cosmological evolution are reconstructed, including ΛCDM cosmology, deceleration with transition to phantom superacceleration era which may develop singularity or be transient. The application of this scheme to viable F(R) gravities unifying inflation with dark energy era is proposed. The additional reconstruction of such models leads to non-leading gravitational correction mainly relevant at the early/late universe and helping to pass the cosmological bounds (if necessary). It is also shown how cosmological reconstruction scheme may be generalized in the presence of scalar field.

  17. The Universe Adventure - The Beginnings of Cosmology

    Science.gov (United States)

    The Universe Adventure [ next ] [ home ] Go The Beginnings of Cosmology Since the beginning of of stars? What do the stars tell us about the future? Where did the Universe come from? Cosmology is will introduce you to Cosmology and the study of the structure, history, and fate of the Universe. In

  18. Notes on Hadza cosmology

    DEFF Research Database (Denmark)

    Skaanes, Thea

    2015-01-01

    Abstract: This article concerns Hadza cosmology examined through objects, rituals and the Hadza concept of epeme. A brief background to the Hadza and the eldwork that informs this study is followed by a close analysis of three key objects that are central to the argument presented. The objects...... are intimately linked to women and to aspects of the social and cosmological identity of the individual makers. one object is a materi- alisation of the woman’s name and it leads to an examination by interview of naming practices more generally. Naming a child gives it a spirit and places the child in a strong...... of ethnographic research indicating the potential and need for further examination of the power and role of objects in Hadza society. Keywords: Hadza, epeme, ritual, cosmology, power objects...

  19. Introduction. Cosmology meets condensed matter.

    Science.gov (United States)

    Kibble, T W B; Pickett, G R

    2008-08-28

    At first sight, low-temperature condensed-matter physics and early Universe cosmology seem worlds apart. Yet, in the last few years a remarkable synergy has developed between the two. It has emerged that, in terms of their mathematical description, there are surprisingly close parallels between them. This interplay has been the subject of a very successful European Science Foundation (ESF) programme entitled COSLAB ('Cosmology in the Laboratory') that ran from 2001 to 2006, itself built on an earlier ESF network called TOPDEF ('Topological Defects: Non-equilibrium Field Theory in Particle Physics, Condensed Matter and Cosmology'). The articles presented in this issue of Philosophical Transactions A are based on talks given at the Royal Society Discussion Meeting 'Cosmology meets condensed matter', held on 28 and 29 January 2008. Many of the speakers had participated earlier in the COSLAB programme, but the strength of the field is illustrated by the presence also of quite a few new participants.

  20. Loop quantum cosmology and singularities.

    Science.gov (United States)

    Struyve, Ward

    2017-08-15

    Loop quantum gravity is believed to eliminate singularities such as the big bang and big crunch singularity. This belief is based on studies of so-called loop quantum cosmology which concerns symmetry-reduced models of quantum gravity. In this paper, the problem of singularities is analysed in the context of the Bohmian formulation of loop quantum cosmology. In this formulation there is an actual metric in addition to the wave function, which evolves stochastically (rather than deterministically as the case of the particle evolution in non-relativistic Bohmian mechanics). Thus a singularity occurs whenever this actual metric is singular. It is shown that in the loop quantum cosmology for a homogeneous and isotropic Friedmann-Lemaître-Robertson-Walker space-time with arbitrary constant spatial curvature and cosmological constant, coupled to a massless homogeneous scalar field, a big bang or big crunch singularity is never obtained. This should be contrasted with the fact that in the Bohmian formulation of the Wheeler-DeWitt theory singularities may exist.

  1. Particle cosmology comes of age

    International Nuclear Information System (INIS)

    Turner, M.S.

    1988-01-01

    The application of modern ideas in particle physics to astrophysical and cosmological settings is a continuation of a fruitful tradition in astrophysics which began with the application of atomic physics, and then nuclear physics. In the past decade particle cosmology and particle astrophysics have been recognized as 'legitimate activities' by both particle physicists and astrophysicists and astronomers. During this time there has been a high level of theoretical activity producing much speculation about the earliest history of the Universe, as well as important and interesting astrophysical and cosmological constraints to particle physics theories. This period of intense theoretical activity has produced a number of ideas most worthy of careful consideration and scrutiny, and even more importantly, amenable to experimental/observational test. Among the ideas which are likely to be tested in the next decade are: the cosmological bound to the number of neutrino flavors, inflation, relic WIMPs as the dark matter, and MSW neutrino oscillations as a solution to the solar neutrino problems. (orig.)

  2. Evolution in bouncing quantum cosmology

    International Nuclear Information System (INIS)

    Mielczarek, Jakub; Piechocki, Włodzimierz

    2012-01-01

    We present the method of describing an evolution in quantum cosmology in the framework of the reduced phase space quantization of loop cosmology. We apply our method to the flat Friedmann-Robertson-Walker model coupled to a massless scalar field. We identify the physical quantum Hamiltonian that is positive-definite and generates globally a unitary evolution of the considered quantum system. We examine the properties of expectation values of physical observables in the process of the quantum big bounce transition. The dispersion of evolved observables is studied for the Gaussian state. Calculated relative fluctuations enable an examination of the semi-classicality conditions and possible occurrence of the cosmic forgetfulness. Preliminary estimations based on the cosmological data suggest that there was no cosmic amnesia. Presented results are analytical, and numerical computations are only used for the visualization purposes. Our method may be generalized to sophisticated cosmological models including the Bianchi-type universes. (paper)

  3. Precision cosmology and the landscape

    International Nuclear Information System (INIS)

    Bousso, Raphael; Bousso, Raphael

    2006-01-01

    After reviewing the cosmological constant problem--why is Lambda not huge?--I outline the two basic approaches that had emerged by the late 1980s, and note that each made a clear prediction. Precision cosmological experiments now indicate that the cosmological constant is nonzero. This result strongly favors the environmental approach, in which vacuum energy can vary discretely among widely separated regions in the universe. The need to explain this variation from first principles constitutes an observational constraint on fundamental theory. I review arguments that string theory satisfies this constraint, as it contains a dense discretuum of metastable vacua. The enormous landscape of vacua calls for novel, statistical methods of deriving predictions, and it prompts us to reexamine our description of spacetime on the largest scales. I discuss the effects of cosmological dynamics, and I speculate that weighting vacua by their entropy production may allow for prior-free predictions that do not resort to explicitly anthropic arguments

  4. Particle cosmology comes of age

    International Nuclear Information System (INIS)

    Turner, M.S.

    1987-12-01

    The application of modern ideas in particle physics to astrophysical and cosmological settings is a continuation of a fruitful tradition in astrophysics which began with the application of atomic physics, and then nuclear physics. In the past decade particle cosmology and particle astrophysics have been recognized as 'legitimate activities' by both particle physicists and astrophysicists and astronomers. During this time there has been a high level of theoretical activity producing much speculation about the earliest history of the Universe, as well as important and interesting astrophysical and cosmological constraints to particle physics theories. This period of intense theoretical activity has produced a number of ideas most worthy of careful consideration and scrutiny, and even more importantly, amenable to experimental/observational test. Among the ideas which are likely to be tested in the next decade are: the cosmological bound to the number of neutrino flavors, inflation, relic WIMPs as the dark matter, and MSW neutrino oscillations as a solution to the solar neutrino problems. 94 refs

  5. The Atacama Cosmology Telescope: Cosmology from Galaxy Clusters Detected via the Sunyaev-Zeldovich Effect

    International Nuclear Information System (INIS)

    Sehgal, N.

    2011-01-01

    We present constraints on cosmological parameters based on a sample of Sunyaev-Zeldovich-selected galaxy clusters detected in a millimeter-wave survey by the Atacama Cosmology Telescope. The cluster sample used in this analysis consists of 9 optically-confirmed high-mass clusters comprising the high-significance end of the total cluster sample identified in 455 square degrees of sky surveyed during 2008 at 148GHz. We focus on the most massive systems to reduce the degeneracy between unknown cluster astrophysics and cosmology derived from SZ surveys. We describe the scaling relation between cluster mass and SZ signal with a 4-parameter fit. Marginalizing over the values of the parameters in this fit with conservative priors gives σ 8 = 0.851 ± 0.115 and w = -1.14 ± 0.35 for a spatially-flat wCDM cosmological model with WMAP 7-year priors on cosmological parameters. This gives a modest improvement in statistical uncertainty over WMAP 7-year constraints alone. Fixing the scaling relation between cluster mass and SZ signal to a fiducial relation obtained from numerical simulations and calibrated by X-ray observations, we find σ 8 = 0.821 ± 0.044 and w = -1.05 ± 0.20. These results are consistent with constraints from WMAP 7 plus baryon acoustic oscillations plus type Ia supernoava which give σ 8 = 0.802 ± 0.038 and w = -0.98 ± 0.053. A stacking analysis of the clusters in this sample compared to clusters simulated assuming the fiducial model also shows good agreement. These results suggest that, given the sample of clusters used here, both the astrophysics of massive clusters and the cosmological parameters derived from them are broadly consistent with current models.

  6. Singular perturbations of empty Robertson-Walker cosmologies

    International Nuclear Information System (INIS)

    Newman, R.P.A.C.

    1979-02-01

    An investigation is presented which concerns a class of cosmological models defined by McVittie (1931): the universe is envisaged as a set of galaxies, idealised as point particles, which provide singular perturbations of Robertson-Walker cosmologies. The perturbations are considered only to first order in the gravitational coupling constant (8πG)/c 2 . Attention will only be given to such perturbations of empty Robertson-Walker cosmologies. Chapter 1 summarises the observational support for the type of model employed and for the smallness of the quantities to be used as perturbation coefficients. Chapter 2 provides the prerequisite analysis of Robertson-Walker cosmologies. Perturbations of empty Robertson-Walker cosmologies of non-vanishing cosmical constant are considered in general in Chapter 3. The structure of McVittie's singularly perturbed Robertson-Walker cosmologies are considered in detail in Chapter 4. The remaining chapters seek to investigate them further by way of their optical properties. Chapter 5 provides the necessary theory of geometric optics with particular regard to the intensity and distortion of a beam of light, and Chapter 6 applies this theory to the McVittie cosmologies. Chapter 7 sees the definition of an averaging procedure which leads to expressions for the intensity and distortion of a typical beam of light from a point source. (author)

  7. Nonsingular cosmology with a scale-invariant spectrum of cosmological perturbations from Lee-Wick theory

    International Nuclear Information System (INIS)

    Cai Yifu; Qiu Taotao; Brandenberger, Robert; Zhang Xinmin

    2009-01-01

    We study the cosmology of a Lee-Wick type scalar field theory. First, we consider homogeneous and isotropic background solutions and find that they are nonsingular, leading to cosmological bounces. Next, we analyze the spectrum of cosmological perturbations which result from this model. Unless either the potential of the Lee-Wick theory or the initial conditions are finely tuned, it is impossible to obtain background solutions which have a sufficiently long period of inflation after the bounce. More interestingly, however, we find that in the generic noninflationary bouncing cosmology, perturbations created from quantum vacuum fluctuations in the contracting phase have the correct form to lead to a scale-invariant spectrum of metric inhomogeneities in the expanding phase. Since the background is nonsingular, the evolution of the fluctuations is defined unambiguously through the bounce. We also analyze the evolution of fluctuations which emerge from thermal initial conditions in the contracting phase. The spectrum of gravitational waves stemming from quantum vacuum fluctuations in the contracting phase is also scale-invariant, and the tensor to scalar ratio is not suppressed.

  8. How fabulous is Fab 5 cosmology?

    International Nuclear Information System (INIS)

    Linder, Eric V.

    2013-01-01

    Extended gravity origins for cosmic acceleration can solve some fine tuning issues and have useful characteristics, but generally have little to say regarding the cosmological constant problem. Fab 5 gravity can be ghost free and stable, have attractor solutions in the past and future, and possess self tuning that solves the original cosmological constant problem. Here we show however it does not possess all these qualities at the same time. We also demonstrate that the self tuning is so powerful that it not only cancels the cosmological constant but also all other energy density, and we derive the scalings of its approach to a renormalized de Sitter cosmology. While this strong cancellation is bad for the late universe, it greatly eases early universe inflation

  9. How fabulous is Fab 5 cosmology?

    Energy Technology Data Exchange (ETDEWEB)

    Linder, Eric V., E-mail: evlinder@lbl.gov [Berkeley Center for Cosmological Physics and Berkeley Lab, University of California, Berkeley, CA, 94720 (United States)

    2013-12-01

    Extended gravity origins for cosmic acceleration can solve some fine tuning issues and have useful characteristics, but generally have little to say regarding the cosmological constant problem. Fab 5 gravity can be ghost free and stable, have attractor solutions in the past and future, and possess self tuning that solves the original cosmological constant problem. Here we show however it does not possess all these qualities at the same time. We also demonstrate that the self tuning is so powerful that it not only cancels the cosmological constant but also all other energy density, and we derive the scalings of its approach to a renormalized de Sitter cosmology. While this strong cancellation is bad for the late universe, it greatly eases early universe inflation.

  10. Cosmology Then and Now

    International Nuclear Information System (INIS)

    Novikov, I.D.

    1999-01-01

    In this talk a brief survey has been carried out on the development of cosmology from the days Leopold Infeld was active in the field up to the present. Attention in particular is paid to the history of our knowledge of Hubble's expansion, of the cosmological constant, of the average density of matter and its distribution, and of the related issue of possible types of matter in the Universe. (author)

  11. Cosmological string theory with thermal energy

    International Nuclear Information System (INIS)

    Shiraishi, Kiyoshi.

    1988-09-01

    An attempt to construct a cosmological scenario directly from string theory is made. Cosmological string theory was presented by Antoniadis, Bachas, Ellis and Nanopoulos. They also expect loop effects on cosmological string theory. In this paper, we point out the other importance of the one-loop effect, the finite temperature effect. The equations of motion for background geometry at finite temperature is given. We address a problem on derivation of the effective action at non-zero temperature. (author)

  12. Gravitational particle production in braneworld cosmology.

    Science.gov (United States)

    Bambi, C; Urban, F R

    2007-11-09

    Gravitational particle production in a time variable metric of an expanding universe is efficient only when the Hubble parameter H is not too small in comparison with the particle mass. In standard cosmology, the huge value of the Planck mass M{Pl} makes the mechanism phenomenologically irrelevant. On the other hand, in braneworld cosmology, the expansion rate of the early Universe can be much faster, and many weakly interacting particles can be abundantly created. Cosmological implications are discussed.

  13. Averaging in spherically symmetric cosmology

    International Nuclear Information System (INIS)

    Coley, A. A.; Pelavas, N.

    2007-01-01

    The averaging problem in cosmology is of fundamental importance. When applied to study cosmological evolution, the theory of macroscopic gravity (MG) can be regarded as a long-distance modification of general relativity. In the MG approach to the averaging problem in cosmology, the Einstein field equations on cosmological scales are modified by appropriate gravitational correlation terms. We study the averaging problem within the class of spherically symmetric cosmological models. That is, we shall take the microscopic equations and effect the averaging procedure to determine the precise form of the correlation tensor in this case. In particular, by working in volume-preserving coordinates, we calculate the form of the correlation tensor under some reasonable assumptions on the form for the inhomogeneous gravitational field and matter distribution. We find that the correlation tensor in a Friedmann-Lemaitre-Robertson-Walker (FLRW) background must be of the form of a spatial curvature. Inhomogeneities and spatial averaging, through this spatial curvature correction term, can have a very significant dynamical effect on the dynamics of the Universe and cosmological observations; in particular, we discuss whether spatial averaging might lead to a more conservative explanation of the observed acceleration of the Universe (without the introduction of exotic dark matter fields). We also find that the correlation tensor for a non-FLRW background can be interpreted as the sum of a spatial curvature and an anisotropic fluid. This may lead to interesting effects of averaging on astrophysical scales. We also discuss the results of averaging an inhomogeneous Lemaitre-Tolman-Bondi solution as well as calculations of linear perturbations (that is, the backreaction) in an FLRW background, which support the main conclusions of the analysis

  14. Particle accelerators test cosmological theory

    International Nuclear Information System (INIS)

    Schramm, D.N.; Steigman, G.

    1988-01-01

    Over the past decade two subfields of science, cosmology and elementary-particle physics, have become married in a symbiotic relationship that has produced a number of exciting offspring. These offspring are beginning to yield insights on the creation of spacetime and matter at epochs as early as 10 to the minus 43 to 10 to the minus 35 second after the birth of the universe in the primordial explosion known as the big bang. Important clues to the nature of the big bang itself may even come from a theory currently under development, known as the ultimate theory of everything (T.E.O.). A T.E.O. would describe all the interactions among the fundamental particles in a single bold stroke. Now that cosmology ahs begun to make predictions about elementary-particle physics, it has become conceivable that those cosmological predictions could be checked with carefully controlled accelerator experiments. It has taken more than 10 years for accelerators to reach the point where they can do the appropriate experiments, but the experiments are now in fact in progress. The preliminary results confirm the predictions of cosmology. The cosmological prediction the authors have been concerned with pertains to setting limits on the number of fundamental particles of matter. It appears that there are 12 fundamental particles, as well as their corresponding antiparticles. Six of the fundamental particles are quarks. The other six are leptons. The 12 particles are grouped in three families, each family consisting of four members. Cosmology suggests there must be a finite number of families and, further limits the possible range of to small values: only three or at most four families exist. 7 figs

  15. Cosmological Structure Formation: From Dawn till Dusk

    DEFF Research Database (Denmark)

    Heneka, Caroline Samantha

    Cosmology has entered an era where a plethora data is available on structure formation to constrain astrophysics and underlying cosmology. This thesis strives to both investigate new observables and modeling of the Epoch of Reionization, as well as to constrain dark energy phenomenology with mass......Cosmology has entered an era where a plethora data is available on structure formation to constrain astrophysics and underlying cosmology. This thesis strives to both investigate new observables and modeling of the Epoch of Reionization, as well as to constrain dark energy phenomenology...... with massive galaxy clusters, traveling from the dawn of structure formation, when the first galaxies appear, to its dusk, when a representative part of the mass in the Universe is settled in massive structures. This hunt for accurate constraints on cosmology is complemented with the demonstration of novel...... Bayesian statistical tools and kinematical constraints on dark energy. Starting at the dawn of structure formation, we study emission line fluctuations, employing semi-numerical simulations of cosmological volumes of their line emission, in order to cross-correlate fluctuations in brightness. This cross...

  16. Holographic (de)confinement transitions in cosmological backgrounds

    International Nuclear Information System (INIS)

    Erdmenger, Johanna; Ghoroku, Kazuo; Meyer, Rene

    2011-01-01

    For type IIB supergravity with a running axio-dilaton, we construct bulk solutions which admit a cosmological background metric of Friedmann-Robertson-Walker type. These solutions include both a dark radiation term in the bulk as well as a four-dimensional (boundary) cosmological constant, while gravity at the boundary remains nondynamical. We holographically calculate the stress-energy tensor, showing that it consists of two contributions: The first one, generated by the dark radiation term, leads to the thermal fluid of N=4 SYM theory, while the second, the conformal anomaly, originates from the boundary cosmological constant. Conservation of the boundary stress-tensor implies that the boundary cosmological constant is time-independent, such that there is no exchange between the two stress-tensor contributions. We then study (de)confinement by evaluating the Wilson loop in these backgrounds. While the dark radiation term favors deconfinement, a negative cosmological constant drives the system into a confined phase. When both contributions are present, we find an oscillating universe with negative cosmological constant which undergoes periodic (de)confinement transitions as the scale of three-space expands and recontracts.

  17. A Time-Dependent Λ and G Cosmological Model Consistent with Cosmological Constraints

    Directory of Open Access Journals (Sweden)

    L. Kantha

    2016-01-01

    Full Text Available The prevailing constant Λ-G cosmological model agrees with observational evidence including the observed red shift, Big Bang Nucleosynthesis (BBN, and the current rate of acceleration. It assumes that matter contributes 27% to the current density of the universe, with the rest (73% coming from dark energy represented by the Einstein cosmological parameter Λ in the governing Friedmann-Robertson-Walker equations, derived from Einstein’s equations of general relativity. However, the principal problem is the extremely small value of the cosmological parameter (~10−52 m2. Moreover, the dark energy density represented by Λ is presumed to have remained unchanged as the universe expanded by 26 orders of magnitude. Attempts to overcome this deficiency often invoke a variable Λ-G model. Cosmic constraints from action principles require that either both G and Λ remain time-invariant or both vary in time. Here, we propose a variable Λ-G cosmological model consistent with the latest red shift data, the current acceleration rate, and BBN, provided the split between matter and dark energy is 18% and 82%. Λ decreases (Λ~τ-2, where τ is the normalized cosmic time and G increases (G~τn with cosmic time. The model results depend only on the chosen value of Λ at present and in the far future and not directly on G.

  18. Cosmological production of noncommutative black holes

    International Nuclear Information System (INIS)

    Mann, Robert B.; Nicolini, Piero

    2011-01-01

    We investigate the pair creation of noncommutative black holes in a background with a positive cosmological constant. As a first step we derive the noncommutative geometry inspired Schwarzschild-de Sitter solution. By varying the mass and the cosmological constant parameters, we find several spacetimes compatible with the new solution: positive-mass spacetimes admit one cosmological horizon and two, one, or no black hole horizons, while negative-mass spacetimes have just a cosmological horizon. These new black holes share the properties of the corresponding asymptotically flat solutions, including the nonsingular core and thermodynamic stability in the final phase of the evaporation. As a second step we determine the action which generates the matter sector of gravitational field equations and we construct instantons describing the pair production of black holes and the other admissible topologies. As a result we find that for current values of the cosmological constant the de Sitter background is quantum mechanically stable according to experience. However, positive-mass noncommutative black holes and solitons would have plentifully been produced during inflationary times for Planckian values of the cosmological constant. As a special result we find that, in these early epochs of the Universe, Planck size black holes production would have been largely disfavored. We also find a potential instability for production of negative-mass solitons.

  19. Quantum Gravity Effects in Cosmology

    Directory of Open Access Journals (Sweden)

    Gu Je-An

    2018-01-01

    Full Text Available Within the geometrodynamic approach to quantum cosmology, we studied the quantum gravity effects in cosmology. The Gibbons-Hawking temperature is corrected by quantum gravity due to spacetime fluctuations and the power spectrum as well as any probe field will experience the effective temperature, a quantum gravity effect.

  20. Cosmological effects of nonlinear electrodynamics

    International Nuclear Information System (INIS)

    Novello, M; Goulart, E; Salim, J M; Bergliaffa, S E Perez

    2007-01-01

    It will be shown that a given realization of nonlinear electrodynamics, used as a source of Einstein's equations, generates a cosmological model with interesting features, namely a phase of current cosmic acceleration, and the absence of an initial singularity, thus pointing to a way of solving two important problems in cosmology

  1. Nikolay Lossky’s Cosmology

    Directory of Open Access Journals (Sweden)

    Gennadii Aliaiev

    2018-02-01

    Full Text Available The paper focuses on cosmological ideas of a twentieth-century Russian philosopher Nikolay Lossky (1870-1965. It specifies the place of these ideas within the entire framework of his philosophical views, as well as in the context of his topology of philosophical systems, in particular ― the discrimination between organic and non-organic worldview. A historico-philosophical analysis of Lossky’s cosmology allows revealing the interaction of gnoseological and ontological principles of his system, e.g. explicating the difference of Lossky’s intuitionism from the one of Bergson. The key section of the organic worldview is the doctrine of the hierarchy of substantival agents: the hierarchical personalism, as well as the notions of transcreation, dynamic understanding of matter, and the doctrine of free will closely related to it. The paper specifies the peculiarities of Lossky’s interpretations of panvitalism and panpsychism, as well as the doctrine of reincarnation, which has a particular place in his system. The final stage of Lossky’s cosmological ideas development is his ontological aesthetics: on this stage he understands the world as an embodiment of beauty. The conclusion is drawn that Lossky’s cosmological doctrine is Christian and metaphysical in its nature.

  2. The Cosmic Mandala: Celebrating Tibetan Cosmologies

    Science.gov (United States)

    Larsen, Kristine

    2008-05-01

    The past decade has seen an increased establishment of Tibetan cultural centers in North America and increased public interest in and media coverage of Tibetan culture. As a result, interest has grown in all aspects of this rich tradition. Astronomy has long played an important role in the lives of the Tibetan people, from their unique luni-solar calendar to their tradition of combining what they call "astro-science" and medicine. To this day, nomads in northern Tibet will ask the North Star - the "Stable Star of the North" - to protect a wayward animal for the night in the expectation that the star will aid in the animal's return in the morning. In Tibetan cosmology, our universe is symbolized as a series of parallel disks centered around Mount Meru, with the heavenly bodies orbiting around it. Central to this cosmology is the concept that time and space have no absolute beginning or end (paralleling the concept of eternal human reincarnation), but that at any given time there exist a billionfold impermanent universes, each one involved in its own independent 4-stage cycle of emptiness, becoming, unfolding, and dissolution. Two distinct symbolic cosmology systems, the Abhidharma ("Topics of special knowledge") and Kalachakra ("Wheel of time"), are recognized in Tibetan culture. These cosmologies also differ in their geographical description of Mount Meru and the "continents" as well as the specifics of the 4-stage cosmological cycle. This poster will celebrate the richness of Tibetan "astro-science", including the calendar, star names, traditional cosmological systems, and astronomical artwork, and demonstrate ways that this tradition can be directly utilized to celebrate and teach cultural cosmologies during the IYA.

  3. Quantum Gravity and Cosmology: an intimate interplay

    Science.gov (United States)

    Sakellariadou, Mairi

    2017-08-01

    I will briefly discuss three cosmological models built upon three distinct quantum gravity proposals. I will first highlight the cosmological rôle of a vector field in the framework of a string/brane cosmological model. I will then present the resolution of the big bang singularity and the occurrence of an early era of accelerated expansion of a geometric origin, in the framework of group field theory condensate cosmology. I will then summarise results from an extended gravitational model based on non-commutative spectral geometry, a model that offers a purely geometric explanation for the standard model of particle physics.

  4. The Atacama Cosmology Telescope: Cosmology from Galaxy Clusters Detected Via the Sunyaev-Zel'dovich Effect

    Science.gov (United States)

    Sehgal, Neelima; Trac, Hy; Acquaviva, Viviana; Ade, Peter A. R.; Aguirre, Paula; Amiri, Mandana; Appel, John W.; Barrientos, L. Felipe; Battistelli, Elia S.; Bond, J. Richard; hide

    2010-01-01

    We present constraints on cosmological parameters based on a sample of Sunyaev-Zel'dovich-selected galaxy clusters detected in a millimeter-wave survey by the Atacama Cosmology Telescope. The cluster sample used in this analysis consists of 9 optically-confirmed high-mass clusters comprising the high-significance end of the total cluster sample identified in 455 square degrees of sky surveyed during 2008 at 148 GHz. We focus on the most massive systems to reduce the degeneracy between unknown cluster astrophysics and cosmology derived from SZ surveys. We describe the scaling relation between cluster mass and SZ signal with a 4-parameter fit. Marginalizing over the values of the parameters in this fit with conservative priors gives (sigma)8 = 0.851 +/- 0.115 and w = -1.14 +/- 0.35 for a spatially-flat wCDM cosmological model with WMAP 7-year priors on cosmological parameters. This gives a modest improvement in statistical uncertainty over WMAP 7-year constraints alone. Fixing the scaling relation between cluster mass and SZ signal to a fiducial relation obtained from numerical simulations and calibrated by X-ray observations, we find (sigma)8 + 0.821 +/- 0.044 and w = -1.05 +/- 0.20. These results are consistent with constraints from WMAP 7 plus baryon acoustic oscillations plus type Ia supernova which give (sigma)8 = 0.802 +/- 0.038 and w = -0.98 +/- 0.053. A stacking analysis of the clusters in this sample compared to clusters simulated assuming the fiducial model also shows good agreement. These results suggest that, given the sample of clusters used here, both the astrophysics of massive clusters and the cosmological parameters derived from them are broadly consistent with current models.

  5. Non-singular string-cosmologies from exact conformal field theories

    International Nuclear Information System (INIS)

    Vega, H.J. de; Larsen, A.L.; Sanchez, N.

    2001-01-01

    Non-singular two and three dimensional string cosmologies are constructed using the exact conformal field theories corresponding to SO(2,1)/SO(1,1) and SO(2,2)/SO(2,1). All semi-classical curvature singularities are canceled in the exact theories for both of these cosets, but some new quantum curvature singularities emerge. However, considering different patches of the global manifolds, allows the construction of non-singular space-times with cosmological interpretation. In both two and three dimensions, we construct non-singular oscillating cosmologies, non-singular expanding and inflationary cosmologies including a de Sitter (exponential) stage with positive scalar curvature as well as non-singular contracting and deflationary cosmologies. Similarities between the two and three dimensional cases suggest a general picture for higher dimensional coset cosmologies: Anisotropy seems to be a generic unavoidable feature, cosmological singularities are generically avoided and it is possible to construct non-singular cosmologies where some spatial dimensions are experiencing inflation while the others experience deflation

  6. The Hubble IR cutoff in holographic ellipsoidal cosmologies

    Energy Technology Data Exchange (ETDEWEB)

    Cataldo, Mauricio [Universidad del Bio-Bio, Departamento de Fisica, Facultad de Ciencias, Concepcion (Chile); Cruz, Norman [Grupo de Cosmologia y Gravitacion-UBB, Concepcion (Chile)

    2018-01-15

    It is well known that for spatially flat FRW cosmologies, the holographic dark energy disfavors the Hubble parameter as a candidate for the IR cutoff. For overcoming this problem, we explore the use of this cutoff in holographic ellipsoidal cosmological models, and derive the general ellipsoidal metric induced by a such holographic energy density. Despite the drawbacks that this cutoff presents in homogeneous and isotropic universes, based on this general metric, we developed a suitable ellipsoidal holographic cosmological model, filled with a dark matter and a dark energy components. At late time stages, the cosmic evolution is dominated by a holographic anisotropic dark energy with barotropic equations of state. The cosmologies expand in all directions in accelerated manner. Since the ellipsoidal cosmologies given here are not asymptotically FRW, the deviation from homogeneity and isotropy of the universe on large cosmological scales remains constant during all cosmic evolution. This feature allows the studied holographic ellipsoidal cosmologies to be ruled by an equation of state ω = p/ρ, whose range belongs to quintessence or even phantom matter. (orig.)

  7. Fourth-rank cosmology

    International Nuclear Information System (INIS)

    Marrakchi, A.E.L.; Tapia, V.

    1992-05-01

    Some cosmological implications of the recently proposed fourth-rank theory of gravitation are studied. The model exhibits the possibility of being free from the horizon and flatness problems at the price of introducing a negative pressure. The field equations we obtain are compatible with k obs =0 and Ω obs t clas approx. 10 20 t Planck approx. 10 -23 s. When interpreted at the light of General Relativity the treatment is shown to be almost equivalent to that of the standard model of cosmology combined with the inflationary scenario. Hence, an interpretation of the negative pressure hypothesis is provided. (author). 8 refs

  8. Magnetohydrodynamics and Plasma Cosmology

    Science.gov (United States)

    Kleidis, Kostas; Kuiroukidis, Apostolos; Papadopoulos, Demetrios; Vlahos, Loukas

    2007-09-01

    We study the linear magnetohydrodynamic (MHD) equations, both in the Newtonian and the general-relativistic limit, as regards a viscous magnetized fluid of finite conductivity and discuss instability criteria. In addition, we explore the excitation of cosmological perturbations in anisotropic spacetimes, in the presence of an ambient magnetic field. Acoustic, electromagnetic (e/m) and fast-magnetosonic modes, propagating normal to the magnetic field, can be excited, resulting in several implications of cosmological significance.

  9. A Planck Vacuum Cosmology

    Directory of Open Access Journals (Sweden)

    Daywitt W. C.

    2009-04-01

    Full Text Available Both the big-bang and the quasi-steady-state cosmologies originate in some type of Planck state. This paper presents a new cosmological theory based on the Planck- vacuum negative-energy state, a state consisting of a degenerate collection of negative- energy Planck particles. A heuristic look at the Einstein field equation provides a con- vincing argument that such a vacuum state could provide a theoretical explanation for the visible universe.

  10. Interacting universes and the cosmological constant

    International Nuclear Information System (INIS)

    Alonso-Serrano, A.; Bastos, C.; Bertolami, O.; Robles-Pérez, S.

    2013-01-01

    In this Letter it is studied the effects that an interaction scheme among universes can have in the values of their cosmological constants. In the case of two interacting universes, the value of the cosmological constant of one of the universes becomes very close to zero at the expense of an increasing value of the cosmological constant of the partner universe. In the more general case of a chain of N interacting universes with periodic boundary conditions, the spectrum of the Hamiltonian splits into a large number of levels, each of them associated with a particular value of the cosmological constant, that can be occupied by single universes revealing a collective behavior that plainly shows that the multiverse is much more than the mere sum of its parts

  11. Interacting universes and the cosmological constant

    Energy Technology Data Exchange (ETDEWEB)

    Alonso-Serrano, A. [Centro de Física “Miguel Catalán”, Instituto de Física Fundamental, Consejo Superior de Investigaciones Científicas, Serrano 121, 28006 Madrid (Spain); Estación Ecológica de Biocosmología, Pedro de Alvarado 14, 06411 Medellín (Spain); Bastos, C. [Instituto de Plasmas e Fusão Nuclear, Instituto Superior Técnico, Avenida Rovisco Pais 1, 1049-001 Lisboa (Portugal); Bertolami, O. [Instituto de Plasmas e Fusão Nuclear, Instituto Superior Técnico, Avenida Rovisco Pais 1, 1049-001 Lisboa (Portugal); Departamento de Física e Astronomia, Faculdade de Ciências da Universidade do Porto, Rua do Campo Alegre 687, 4169-007 Porto (Portugal); Robles-Pérez, S., E-mail: salvarp@imaff.cfmac.csic.es [Centro de Física “Miguel Catalán”, Instituto de Física Fundamental, Consejo Superior de Investigaciones Científicas, Serrano 121, 28006 Madrid (Spain); Estación Ecológica de Biocosmología, Pedro de Alvarado 14, 06411 Medellín (Spain); Física Teórica, Universidad del País Vasco, Apartado 644, 48080 Bilbao (Spain)

    2013-02-12

    In this Letter it is studied the effects that an interaction scheme among universes can have in the values of their cosmological constants. In the case of two interacting universes, the value of the cosmological constant of one of the universes becomes very close to zero at the expense of an increasing value of the cosmological constant of the partner universe. In the more general case of a chain of N interacting universes with periodic boundary conditions, the spectrum of the Hamiltonian splits into a large number of levels, each of them associated with a particular value of the cosmological constant, that can be occupied by single universes revealing a collective behavior that plainly shows that the multiverse is much more than the mere sum of its parts.

  12. Brane cosmology in teleparallel and f (T ) gravity

    International Nuclear Information System (INIS)

    Atazadeh, K; Eghbali, A

    2015-01-01

    We consider the cosmology of a brane-world scenario in the framework of teleparallel and f(T) gravity in a way that matter is localized on the brane. We show that the cosmology of such branes is different from the standard cosmology in teleparallelism. In particular, we obtain a class of new solutions with a constant five-dimensional radius and cosmologically evolving brane in the context of constant torsion f(T) gravity. (paper)

  13. Cosmological D-instantons and cyclic universes

    International Nuclear Information System (INIS)

    Bergshoeff, E A; Collinucci, A; Roest, D; Russo, J G; Townsend, P K

    2005-01-01

    For models of gravity coupled to hyperbolic sigma models, such as the metric-scalar sector of IIB supergravity, we show how smooth trajectories in the 'augmented target space' connect FLRW cosmologies to non-extremal D-instantons through a cosmological singularity. In particular, we find closed cyclic universes that undergo an endless sequence of big-bang to big-crunch cycles separated by instanton 'phases'. We also find 'big-bounce' universes in which a collapsing closed universe bounces off its cosmological singularity to become an open expanding universe

  14. State of the art in cosmology

    International Nuclear Information System (INIS)

    Zel'dovich, Ya.B.

    1983-01-01

    The present state of the art in cosmology is under discussion. The general picture of the Universe evolution is presented, and its main stages are outlined. The prooess of formation of the large scale Universe structure is considered. The possibility of investigation into the ''inflation'' period of the ''very-very early Universe'' from the view point of theoretical physics is sown. It is noted that cosmology will become a complete science only when physics gives an exhaustive answer to all issues raised by cosmology

  15. Kerr metric in cosmological background

    Energy Technology Data Exchange (ETDEWEB)

    Vaidya, P C [Gujarat Univ., Ahmedabad (India). Dept. of Mathematics

    1977-06-01

    A metric satisfying Einstein's equation is given which in the vicinity of the source reduces to the well-known Kerr metric and which at large distances reduces to the Robertson-Walker metric of a nomogeneous cosmological model. The radius of the event horizon of the Kerr black hole in the cosmological background is found out.

  16. Cosmological constraints on the amplitude of relic gravitational waves

    International Nuclear Information System (INIS)

    Novosyadlij, B.; Apunevich, S.

    2005-01-01

    The evolution of the amplitude of relic gravitational waves (RGW) generated in early Universe has been analyzed. The analytical approximation is presented for angular power spectrum of cosmic microwave background anisotropies caused by gravitational waves through Sachs-Wolfe effect. The estimate of the most probable value for this amplitude was obtained on the basis of observation data on cosmic microwave background anisotropies from COBE, WMAP and BOOMERanG experiments along with large-scale structure observations

  17. Cosmology comes of age

    International Nuclear Information System (INIS)

    2006-01-01

    This year's Nobel prize is welcome recognition for cosmology. Back in the 1960s, according to Paul Davies' new book The Goldilocks Enigma (see 'Seeking anthropic answers' in this issue), cynics used to quip that there is 'speculation, speculation squared - and cosmology'. Anyone trying to understand the origin and fate of the universe was, in other words, dealing with questions that were simply impractical - or even impossible - to answer. But that has all changed with the development of new telescopes, satellites and data-processing techniques - to the extent that cosmology is now generally viewed as a perfectly acceptable branch of science. If anyone was in any doubt of cosmology's new status, the Royal Swedish Academy of Sciences last month gave the subject welcome recognition with the award of this year's Nobel prize to John Mather and George Smoot (see pp6-7; print version only). The pair were the driving force behind the COBE satellite that in 1992 produced the now famous image of the cosmic microwave background. The mission's data almost certainly proved that the universe started with a Big Bang, while tiny fluctuations in the temperature signal between different parts of the sky were shown to be the seeds of the stars and galaxies we see today. These results are regarded by many as the start of a new era of 'precision cosmology'. But for cosmologists, the job is far from over. There are still massive holes in our understanding of the cosmos, notably the nature of dark matter and dark energy, which together account for over 95% of the total universe. Indeed, some regard dark energy and matter as just ad hoc assumptions needed to fit the data. (Hypothetical particles called 'axions' are one possible contender for dark matter (see pp20-23; print version only), but don't bet your house on it.) Some physicists even think it makes more sense to adjust Newtonian gravity rather than invoke dark matter. But the notion that cosmology is in crisis, as argued by some

  18. The current status of observational cosmology

    Indian Academy of Sciences (India)

    in quality, quantity and the scope of cosmological observations. The measurement .... In this article, we limit our attention to the simplest case of a cosmological ... On the large angular scales, the CMB anisotropy directly probes the primordial.

  19. The Concept of Fractal Cosmos: I. Anaxagoras' Cosmology

    Science.gov (United States)

    Grujic, P. V.

    The concept of a fractal cosmos occupies a prominent position in the modern cosmology. We trace the development of this concept from the presocratic Greece to the present state of affairs. In this first part we consider the original idea due to Anaxagoras and elucidate a number of points with regard to possible interpretation of his cosmological ideas. A comparison has been made with the cosmology of Abderian school and relevance to the modern cosmology discussed.

  20. The concept of fractal cosmos, I: Anaxagoras’ cosmology

    Directory of Open Access Journals (Sweden)

    Grujić P.V.

    2001-01-01

    Full Text Available The concept of a fractal cosmos occupies a prominent position in the modern cosmology. We trace the development of this concept from the presocratic Greece to the present state of affairs. In this first part we consider the original idea due to Anaxagoras and elucidate a number of points with regard to possible interpretation of his cosmological ideas. A comparison has been made with the cosmology of Abderian school and relevance to the modern cosmology discussed.

  1. The concept of fractal cosmos, I: Anaxagoras’ cosmology

    OpenAIRE

    Grujić P.V.

    2001-01-01

    The concept of a fractal cosmos occupies a prominent position in the modern cosmology. We trace the development of this concept from the presocratic Greece to the present state of affairs. In this first part we consider the original idea due to Anaxagoras and elucidate a number of points with regard to possible interpretation of his cosmological ideas. A comparison has been made with the cosmology of Abderian school and relevance to the modern cosmology discussed.

  2. Conformal cosmological model and SNe Ia data

    International Nuclear Information System (INIS)

    Zakharov, A. F.; Pervushin, V. N.

    2012-01-01

    Now there is a huge scientific activity in astrophysical studies and cosmological ones in particular. Cosmology transforms from a pure theoretical branch of science into an observational one. All the cosmological models have to pass observational tests. The supernovae type Ia (SNe Ia) test is among the most important ones. If one applies the test to determine parameters of the standard Friedmann-Robertson-Walker cosmological model one can conclude that observations lead to the discovery of the dominance of the Λ term and as a result to an acceleration of the Universe. However, there are big mysteries connected with an origin and an essence of dark matter (DM) and the Λ term or dark energy (DE). Alternative theories of gravitation are treated as a possible solution of DM and DE puzzles. The conformal cosmological approach is one of possible alternatives to the standard ΛCDM model. As it was noted several years ago, in the framework of the conformal cosmological approach an introduction of a rigid matter can explain observational data without Λ term (or dark energy). We confirm the claim with much larger set of observational data.

  3. Generation of HEXA-deficient hiPSCs from fibroblasts of a Tay-Sachs disease patient.

    Science.gov (United States)

    Liu, Zhong; Zhao, Rui

    2016-09-01

    Human iPSC line TSD-01-hiPSC was generated from fibroblasts of a patient with infantile Tay-Sachs disease (TSD). The patient is compound heterozygous at the HEXA gene by carrying a 1278insTATC allele and an IVS12+1G>C allele. STEMCCA lentivirus, which expresses OCT4, SOX2, KLF4, and c-MYC from a polycistronic transcript, were used for reprogramming. TSD-01-hiPSC express pluripotency markers such as OCT4, SOX2, NANOG, Tra-1-60, and alkaline phosphatase, and can differentiate into tissues from all the three embryonic germ layers. This TSD patient-derived hiPSC line may serve as a valuable in vitro tool for disease modeling and drug test. Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.

  4. Late-onset Tay-Sachs disease: the spectrum of peripheral neuropathy in 30 affected patients.

    Science.gov (United States)

    Shapiro, Barbara E; Logigian, Eric L; Kolodny, Edwin H; Pastores, Gregory M

    2008-08-01

    Late-onset Tay-Sachs (LOTS) disease is a chronic, progressive, lysosomal storage disorder caused by a partial deficiency of beta-hexosaminidase A (HEXA) activity. Deficient levels of HEXA result in the intracellular accumulation of GM2-ganglioside, resulting in toxicity to nerve cells. Clinical manifestations primarily involve the central nervous system (CNS) and lower motor neurons, and include ataxia, weakness, spasticity, dysarthria, dysphagia, dystonia, seizures, psychosis, mania, depression, and cognitive decline. The prevalence of peripheral nervous system (PNS) involvement in LOTS has not been well documented, but it has traditionally been thought to be very low. We examined a cohort of 30 patients with LOTS who underwent clinical and electrophysiologic examination, and found evidence of a predominantly axon loss polyneuropathy affecting distal nerve segments in the lower and upper extremities in eight patients (27%).

  5. Exact Solution and Exotic Fluid in Cosmology

    Directory of Open Access Journals (Sweden)

    Phillial Oh

    2012-09-01

    Full Text Available We investigate cosmological consequences of nonlinear sigma model coupled with a cosmological fluid which satisfies the continuity equation. The target space action is of the de Sitter type and is composed of four scalar fields. The potential which is a function of only one of the scalar fields is also introduced. We perform a general analysis of the ensuing cosmological equations and give various critical points and their properties. Then, we show that the model exhibits an exact cosmological solution which yields a transition from matter domination into dark energy epoch and compare it with the Λ-CDM behavior. Especially, we calculate the age of the Universe and show that it is consistent with the observational value if the equation of the state ωf of the cosmological fluid is within the range of 0.13 < ωf < 0.22. Some implication of this result is also discussed.

  6. How does pressure gravitate? Cosmological constant problem confronts observational cosmology

    Science.gov (United States)

    Narimani, Ali; Afshordi, Niayesh; Scott, Douglas

    2014-08-01

    An important and long-standing puzzle in the history of modern physics is the gross inconsistency between theoretical expectations and cosmological observations of the vacuum energy density, by at least 60 orders of magnitude, otherwise known as the cosmological constant problem. A characteristic feature of vacuum energy is that it has a pressure with the same amplitude, but opposite sign to its energy density, while all the precision tests of General Relativity are either in vacuum, or for media with negligible pressure. Therefore, one may wonder whether an anomalous coupling to pressure might be responsible for decoupling vacuum from gravity. We test this possibility in the context of the Gravitational Aether proposal, using current cosmological observations, which probe the gravity of relativistic pressure in the radiation era. Interestingly, we find that the best fit for anomalous pressure coupling is about half-way between General Relativity (GR), and Gravitational Aether (GA), if we include Planck together with WMAP and BICEP2 polarization cosmic microwave background (CMB) observations. Taken at face value, this data combination excludes both GR and GA at around the 3 σ level. However, including higher resolution CMB observations (``highL'') or baryonic acoustic oscillations (BAO) pushes the best fit closer to GR, excluding the Gravitational Aether solution to the cosmological constant problem at the 4- 5 σ level. This constraint effectively places a limit on the anomalous coupling to pressure in the parametrized post-Newtonian (PPN) expansion, ζ4 = 0.105 ± 0.049 (+highL CMB), or ζ4 = 0.066 ± 0.039 (+BAO). These represent the most precise measurement of this parameter to date, indicating a mild tension with GR (for ΛCDM including tensors, with 0ζ4=), and also among different data sets.

  7. How does pressure gravitate? Cosmological constant problem confronts observational cosmology

    International Nuclear Information System (INIS)

    Narimani, Ali; Scott, Douglas; Afshordi, Niayesh

    2014-01-01

    An important and long-standing puzzle in the history of modern physics is the gross inconsistency between theoretical expectations and cosmological observations of the vacuum energy density, by at least 60 orders of magnitude, otherwise known as the cosmological constant problem. A characteristic feature of vacuum energy is that it has a pressure with the same amplitude, but opposite sign to its energy density, while all the precision tests of General Relativity are either in vacuum, or for media with negligible pressure. Therefore, one may wonder whether an anomalous coupling to pressure might be responsible for decoupling vacuum from gravity. We test this possibility in the context of the Gravitational Aether proposal, using current cosmological observations, which probe the gravity of relativistic pressure in the radiation era. Interestingly, we find that the best fit for anomalous pressure coupling is about half-way between General Relativity (GR), and Gravitational Aether (GA), if we include Planck together with WMAP and BICEP2 polarization cosmic microwave background (CMB) observations. Taken at face value, this data combination excludes both GR and GA at around the 3 σ level. However, including higher resolution CMB observations (''highL'') or baryonic acoustic oscillations (BAO) pushes the best fit closer to GR, excluding the Gravitational Aether solution to the cosmological constant problem at the 4- 5 σ level. This constraint effectively places a limit on the anomalous coupling to pressure in the parametrized post-Newtonian (PPN) expansion, ζ 4  = 0.105 ± 0.049 (+highL CMB), or ζ 4  = 0.066 ± 0.039 (+BAO). These represent the most precise measurement of this parameter to date, indicating a mild tension with GR (for ΛCDM including tensors, with 0ζ 4 =), and also among different data sets

  8. Cosmology with clusters in the CMB

    International Nuclear Information System (INIS)

    Majumdar, Subhabrata

    2008-01-01

    Ever since the seminal work by Sunyaev and Zel'dovich describing the distortion of the CMB spectrum, due to photons passing through the hot inter cluster gas on its way to us from the surface of last scattering (the so called Sunyaev-Zel'dovich effect (SZE)), small scale distortions of the CMB by clusters has been used to detect clusters as well as to do cosmology with clusters. Cosmology with clusters in the CMB can be divided into three distinct regimes: a) when the clusters are completely unresolved and contribute to the secondary CMB distortions power spectrum at small angular scales; b) when we can just about resolve the clusters so as to detect the clusters through its total SZE flux such that the clusters can be tagged and counted for doing cosmology and c) when we can completely resolve the clusters so as to measure their sizes and other cluster structural properties and their evolution with redshift. In this article, we take a look at these three aspects of SZE cluster studies and their implication for using clusters as cosmological probes. We show that clusters can be used as effective probes of cosmology, when in all of these three cases, one explores the synergy between cluster physics and cosmology as well take clues about cluster physics from the latest high precision cluster observations (for example, from Chandra and XMM - Newton). As a specific case, we show how an observationally motivated cluster SZ template can explain the CBI-excess without the need for a high σ 8 . We also briefly discuss 'self-calibration' in cluster surveys and the prospect of using clusters as an ensemble of cosmic rulers to break degeneracies arising in cluster cosmology.

  9. The Effective Field Theory of nonsingular cosmology

    Energy Technology Data Exchange (ETDEWEB)

    Cai, Yong [School of Physics, University of Chinese Academy of Sciences,Beijing 100049 (China); Wan, Youping [School of Physics, University of Chinese Academy of Sciences,Beijing 100049 (China); CAS Key Laboratory for Research in Galaxies and Cosmology, Department of Astronomy,University of Science and Technology of China, Chinese Academy of Sciences,Hefei, Anhui 230026 (China); Li, Hai-Guang [School of Physics, University of Chinese Academy of Sciences,Beijing 100049 (China); Qiu, Taotao [Institute of Astrophysics, Central China Normal University,Wuhan 430079 (China); Key Laboratory of Quark and Lepton Physics (MOE), Central China Normal University,Wuhan 430079 (China); Piao, Yun-Song [School of Physics, University of Chinese Academy of Sciences,Beijing 100049 (China); Institute of Theoretical Physics, Chinese Academy of Sciences,P.O. Box 2735, Beijing 100190 (China)

    2017-01-20

    In this paper, we explore the nonsingular cosmology within the framework of the Effective Field Theory (EFT) of cosmological perturbations. Due to the recently proved no-go theorem, any nonsingular cosmological models based on the cubic Galileon suffer from pathologies. We show how the EFT could help us clarify the origin of the no-go theorem, and offer us solutions to break the no-go. Particularly, we point out that the gradient instability can be removed by using some spatial derivative operators in EFT. Based on the EFT description, we obtain a realistic healthy nonsingular cosmological model, and show the perturbation spectrum can be consistent with the observations.

  10. The Effective Field Theory of nonsingular cosmology

    International Nuclear Information System (INIS)

    Cai, Yong; Wan, Youping; Li, Hai-Guang; Qiu, Taotao; Piao, Yun-Song

    2017-01-01

    In this paper, we explore the nonsingular cosmology within the framework of the Effective Field Theory (EFT) of cosmological perturbations. Due to the recently proved no-go theorem, any nonsingular cosmological models based on the cubic Galileon suffer from pathologies. We show how the EFT could help us clarify the origin of the no-go theorem, and offer us solutions to break the no-go. Particularly, we point out that the gradient instability can be removed by using some spatial derivative operators in EFT. Based on the EFT description, we obtain a realistic healthy nonsingular cosmological model, and show the perturbation spectrum can be consistent with the observations.

  11. The philosophy of cosmology

    CERN Document Server

    Silk, Joseph; Barrow, John D; Saunders, Simon

    2017-01-01

    Following a long-term international collaboration between leaders in cosmology and the philosophy of science, this volume addresses foundational questions at the limit of science across these disciplines, questions raised by observational and theoretical progress in modern cosmology. Space missions have mapped the Universe up to its early instants, opening up questions on what came before the Big Bang, the nature of space and time, and the quantum origin of the Universe. As the foundational volume of an emerging academic discipline, experts from relevant fields lay out the fundamental problems of contemporary cosmology and explore the routes toward finding possible solutions. Written for graduates and researchers in physics and philosophy, particular efforts are made to inform academics from other fields, as well as the educated public, who wish to understand our modern vision of the Universe, related philosophical questions, and the significant impacts on scientific methodology.

  12. The cosmological principle is not in the sky

    Science.gov (United States)

    Park, Chan-Gyung; Hyun, Hwasu; Noh, Hyerim; Hwang, Jai-chan

    2017-08-01

    The homogeneity of matter distribution at large scales, known as the cosmological principle, is a central assumption in the standard cosmological model. The case is testable though, thus no longer needs to be a principle. Here we perform a test for spatial homogeneity using the Sloan Digital Sky Survey Luminous Red Galaxies (LRG) sample by counting galaxies within a specified volume with the radius scale varying up to 300 h-1 Mpc. We directly confront the large-scale structure data with the definition of spatial homogeneity by comparing the averages and dispersions of galaxy number counts with allowed ranges of the random distribution with homogeneity. The LRG sample shows significantly larger dispersions of number counts than the random catalogues up to 300 h-1 Mpc scale, and even the average is located far outside the range allowed in the random distribution; the deviations are statistically impossible to be realized in the random distribution. This implies that the cosmological principle does not hold even at such large scales. The same analysis of mock galaxies derived from the N-body simulation, however, suggests that the LRG sample is consistent with the current paradigm of cosmology, thus the simulation is also not homogeneous in that scale. We conclude that the cosmological principle is neither in the observed sky nor demanded to be there by the standard cosmological world model. This reveals the nature of the cosmological principle adopted in the modern cosmology paradigm, and opens a new field of research in theoretical cosmology.

  13. Brane world cosmologies with varying speed of light

    International Nuclear Information System (INIS)

    Youm, Donam

    2001-02-01

    We study cosmologies in the Randall-Sundrum models, incorporating the possibility of time-varying speed of light and Newton's constant. The cosmologies with varying speed of light (VSL) were proposed by Moffat and by Albrecht and Magueijo as an alternative to inflation for solving the cosmological problems. We consider the case in which the speed of light varies with time after the radion or the scale of the extra dimension has been stabilized. We elaborate on the conditions under which the flatness problem and the cosmological constant problem can be resolved. Particularly, the VSL cosmologies may provide a possible mechanism for bringing the quantum corrections to the fine-tuned brane tensions after the SUSY breaking under control. (author)

  14. Introduction to gravity and cosmology

    International Nuclear Information System (INIS)

    Jauneau, L.

    1988-09-01

    Relativity principles, equivalence principles, and the general covariance principle are introduced. Curved space analysis via tensor calculus and absolute differential calculus is outlined. Einstein's equations are presented. The Schwarzschild solution; tests of general relativity; and black holes are discussed. Application of general relativity to cosmology is considered. The Standard Model of cosmology and its extensions are reviewed

  15. Revolutions in astronomy, physics and cosmology

    International Nuclear Information System (INIS)

    Idlis, G.M.

    1985-01-01

    As consecutive turning-points in the development of natural science four global natural science revolutions (Aristotelian, Newton, Einstein and post-Einstein) are marked out and briefly outlined. Each of them simultaneously occurred in astronomy, physics and cosmology and was accompanied by radical changes of cosmological representations. These changes had quite a regular consecutive character and represented necessary steps in turn along the natural way of further elimination of ego centrism from cosmology. The first (Aristotelian) revolution turnes out a peculiar prototype of all three subsequent revolutions in astronomy, physics and cosmology. The special more detailed analysis of this revolution in this monograph allows one to tie together antique and modern phases of the science development including corresponding representations on fundamental structural elements of the matter. Besides the review of literature data the monograph comprises a series of author's scientific results

  16. Self-accelerating universe in Galileon cosmology

    International Nuclear Information System (INIS)

    Silva, Fabio P.; Koyama, Kazuya

    2009-01-01

    We present a cosmological model with a solution that self-accelerates at late times without signs of ghost instabilities on small scales. The model is a natural extension of the Brans-Dicke (BD) theory including a nonlinear derivative interaction, which appears in a theory with the Galilean shift symmetry. The existence of the self-accelerating universe requires a negative BD parameter but, thanks to the nonlinear term, small fluctuations around the solution are stable on small scales. General relativity is recovered at early times and on small scales by this nonlinear interaction via the Vainshtein mechanism. At late time, gravity is strongly modified and the background cosmology shows a phantomlike behavior and the growth rate of structure formation is enhanced. Thus this model leaves distinct signatures in cosmological observations and it can be distinguished from standard LCDM cosmology.

  17. Combination and interpretation of observables in Cosmology

    Directory of Open Access Journals (Sweden)

    Virey Jean-Marc

    2010-04-01

    Full Text Available The standard cosmological model has deep theoretical foundations but need the introduction of two major unknown components, dark matter and dark energy, to be in agreement with various observations. Dark matter describes a non-relativistic collisionless fluid of (non baryonic matter which amount to 25% of the total density of the universe. Dark energy is a new kind of fluid not of matter type, representing 70% of the total density which should explain the recent acceleration of the expansion of the universe. Alternatively, one can reject this idea of adding one or two new components but argue that the equations used to make the interpretation should be modified consmological scales. Instead of dark matter one can invoke a failure of Newton's laws. Instead of dark energy, two approaches are proposed : general relativity (in term of the Einstein equation should be modified, or the cosmological principle which fixes the metric used for cosmology should be abandonned. One of the main objective of the community is to find the path of the relevant interpretations thanks to the next generation of experiments which should provide large statistics of observationnal data. Unfortunately, cosmological in formations are difficult to pin down directly fromt he measurements, and it is mandatory to combine the various observables to get the cosmological parameters. This is not problematic from the statistical point of view, but assumptions and approximations made for the analysis may bias our interprettion of the data. Consequently, a strong attention should be paied to the statistical methods used to make parameters estimation and for model testing. After a review of the basics of cosmology where the cosmological parameters are introduced, we discuss the various cosmological probes and their associated observables used to extract cosmological informations. We present the results obtained from several statistical analyses combining data of diferent nature but

  18. Regional averaging and scaling in relativistic cosmology

    International Nuclear Information System (INIS)

    Buchert, Thomas; Carfora, Mauro

    2002-01-01

    Averaged inhomogeneous cosmologies lie at the forefront of interest, since cosmological parameters such as the rate of expansion or the mass density are to be considered as volume-averaged quantities and only these can be compared with observations. For this reason the relevant parameters are intrinsically scale-dependent and one wishes to control this dependence without restricting the cosmological model by unphysical assumptions. In the latter respect we contrast our way to approach the averaging problem in relativistic cosmology with shortcomings of averaged Newtonian models. Explicitly, we investigate the scale-dependence of Eulerian volume averages of scalar functions on Riemannian three-manifolds. We propose a complementary view of a Lagrangian smoothing of (tensorial) variables as opposed to their Eulerian averaging on spatial domains. This programme is realized with the help of a global Ricci deformation flow for the metric. We explain rigorously the origin of the Ricci flow which, on heuristic grounds, has already been suggested as a possible candidate for smoothing the initial dataset for cosmological spacetimes. The smoothing of geometry implies a renormalization of averaged spatial variables. We discuss the results in terms of effective cosmological parameters that would be assigned to the smoothed cosmological spacetime. In particular, we find that on the smoothed spatial domain B-bar evaluated cosmological parameters obey Ω-bar B-bar m + Ω-bar B-bar R + Ω-bar B-bar A + Ω-bar B-bar Q 1, where Ω-bar B-bar m , Ω-bar B-bar R and Ω-bar B-bar A correspond to the standard Friedmannian parameters, while Ω-bar B-bar Q is a remnant of cosmic variance of expansion and shear fluctuations on the averaging domain. All these parameters are 'dressed' after smoothing out the geometrical fluctuations, and we give the relations of the 'dressed' to the 'bare' parameters. While the former provide the framework of interpreting observations with a 'Friedmannian bias

  19. Modern cosmology

    International Nuclear Information System (INIS)

    Zeldovich, Y.B.

    1983-01-01

    This paper fives a general review of modern cosmology. The following subjects are discussed: hot big bang and periodization of the evolution; Hubble expansion; the structure of the universe (pancake theory); baryon asymmetry; inflatory universe. (Auth.)

  20. Miglustat in late-onset Tay-Sachs disease: a 12-month, randomized, controlled clinical study with 24 months of extended treatment.

    Science.gov (United States)

    Shapiro, Barbara E; Pastores, Gregory M; Gianutsos, John; Luzy, Cécile; Kolodny, Edwin H

    2009-06-01

    To evaluate the safety and efficacy of miglustat in patients with GM2 gangliosidosis. A randomized, multicenter, open-label, 12-month study involving patients aged 18 years or older, randomized 2:1 to miglustat (200 mg TID) or "no miglustat treatment." This study was followed by 24 months of extended treatment during which all patients received miglustat. Primary efficacy endpoints were change in eight measures of isometric muscle strength in the limbs and isometric grip strength, evaluated at baseline, and months 12 and 36. Secondary efficacy endpoints included gait, balance, disability, and other neurological assessments. Safety evaluations included adverse event reporting. Thirty patients (67% male, age range 18-56 years) with late-onset Tay-Sachs disease were enrolled; 20 were randomized to miglustat and 10 to "no miglustat treatment." Muscle and grip strength generally decreased over the study period. No differences were observed between the two groups in any efficacy measure, either during the 12-month randomized phase or the full 36 months. The most common treatment-related adverse events were decrease in weight and diarrhea. Miglustat treatment was not shown to lead to measurable benefits in this cohort of patients with late-onset Tay-Sachs disease. The observed safety profile was consistent with that of the approved dose (100 mg TID) in type 1 Gaucher disease.

  1. A natural cosmological constant from chameleons

    International Nuclear Information System (INIS)

    Nastase, Horatiu; Weltman, Amanda

    2015-01-01

    We present a simple model where the effective cosmological constant appears from chameleon scalar fields. For a Kachru–Kallosh–Linde–Trivedi (KKLT)-inspired form of the potential and a particular chameleon coupling to the local density, patches of approximately constant scalar field potential cluster around regions of matter with density above a certain value, generating the effect of a cosmological constant on large scales. This construction addresses both the cosmological constant problem (why Λ is so small, yet nonzero) and the coincidence problem (why Λ is comparable to the matter density now)

  2. A natural cosmological constant from chameleons

    Directory of Open Access Journals (Sweden)

    Horatiu Nastase

    2015-07-01

    Full Text Available We present a simple model where the effective cosmological constant appears from chameleon scalar fields. For a Kachru–Kallosh–Linde–Trivedi (KKLT-inspired form of the potential and a particular chameleon coupling to the local density, patches of approximately constant scalar field potential cluster around regions of matter with density above a certain value, generating the effect of a cosmological constant on large scales. This construction addresses both the cosmological constant problem (why Λ is so small, yet nonzero and the coincidence problem (why Λ is comparable to the matter density now.

  3. A natural cosmological constant from chameleons

    Energy Technology Data Exchange (ETDEWEB)

    Nastase, Horatiu, E-mail: nastase@ift.unesp.br [Instituto de Física Teórica, UNESP-Universidade Estadual Paulista, R. Dr. Bento T. Ferraz 271, Bl. II, Sao Paulo 01140-070, SP (Brazil); Weltman, Amanda, E-mail: amanda.weltman@uct.ac.za [Astrophysics, Cosmology & Gravity Center, Department of Mathematics and Applied Mathematics, University of Cape Town, Private Bag, Rondebosch 7700 (South Africa)

    2015-07-30

    We present a simple model where the effective cosmological constant appears from chameleon scalar fields. For a Kachru–Kallosh–Linde–Trivedi (KKLT)-inspired form of the potential and a particular chameleon coupling to the local density, patches of approximately constant scalar field potential cluster around regions of matter with density above a certain value, generating the effect of a cosmological constant on large scales. This construction addresses both the cosmological constant problem (why Λ is so small, yet nonzero) and the coincidence problem (why Λ is comparable to the matter density now)

  4. Particles and cosmology

    International Nuclear Information System (INIS)

    Tkachev, Igor

    1993-01-01

    When the common ground between particle physics, astrophysics and cosmology started to become a developing area, the Institute for Nuclear Research (INR) of the Russian Academy of Sciences had the foresight in 1981 to institute the Baksan Schools on Particles and Cosmology. This now traditional event, held biannually in the Baksan Valley, has gone on to attract international participation. The site is close to the INR Baksan Neutrino Observatory with its underground and surface installations, including the SAGE gallium solar neutrino detector, the Underground Scintillation Telescope, and the 'Carpet' extensive air shower array. Participation is mainly from experimentalists working in non accelerator particle physics and particle astrophysics. The most recent School, held from April 21 to 28, began with an opening address by INR Director V. A. Matveev. J.Frieman reviewed standard big bang cosmology, emphasizing how the recent COBE results and the observations of large scale galaxy clustering fit into a standard cosmology framework. For inflationary cosmology, he showed how different models may be tested through their predictions for large-scale galactic structure and for cosmic microwave background anisotropy. A.Stebbins presented details of the large scale distribution of galaxies which, combined with velocity information and microwave background anisotropy data, provide strong constraints on theories of the origin of primordial inhomogeneities. Inflation requires, and theories of the large scale structure strongly favour the critical value for the cosmic mass density, while, as D.Seckel explained in his lecture on nucleosynthesis and abundances of the light elements, the baryon contribution to this density has to be tens of times smaller. A general review on the observational evidence for dark matter, dark matter particle candidates and the strategy of dark matter searches was given by I. Tkachev, who stressed the gravitational microlensing MACHO

  5. Integrable scalar cosmologies

    International Nuclear Information System (INIS)

    Fré, P.; Sorin, A.S.; Trigiante, M.

    2014-01-01

    The question whether the integrable one-field cosmologies classified in a previous paper by Fré, Sagnotti and Sorin can be embedded as consistent one-field truncations into Extended Gauged Supergravity or in N=1 supergravity gauged by a superpotential without the use of D-terms is addressed in this paper. The answer is that such an embedding is very difficult and rare but not impossible. Indeed, we were able to find two examples of integrable models embedded in supergravity in this way. Both examples are fitted into N=1 supergravity by means of a very specific and interesting choice of the superpotential W(z). The question whether there are examples of such an embedding in Extended Gauged Supergravity remains open. In the present paper, relying on the embedding tensor formalism we classified all gaugings of the N=2 STU model, confirming, in the absence on hypermultiplets, the uniqueness of the stable de Sitter vacuum found several years ago by Fré, Trigiante and Van Proeyen and excluding the embedding of any integrable cosmological model. A detailed analysis of the space of exact solutions of the first supergravity-embedded integrable cosmological model revealed several new features worth an in-depth consideration. When the scalar potential has an extremum at a negative value, the Universe necessarily collapses into a Big Crunch notwithstanding its spatial flatness. The causal structure of these Universes is quite different from that of the closed, positive curved, Universe: indeed, in this case the particle and event horizons do not coincide and develop complicated patterns. The cosmological consequences of this unexpected mechanism deserve careful consideration

  6. Is cosmology consistent?

    International Nuclear Information System (INIS)

    Wang Xiaomin; Tegmark, Max; Zaldarriaga, Matias

    2002-01-01

    We perform a detailed analysis of the latest cosmic microwave background (CMB) measurements (including BOOMERaNG, DASI, Maxima and CBI), both alone and jointly with other cosmological data sets involving, e.g., galaxy clustering and the Lyman Alpha Forest. We first address the question of whether the CMB data are internally consistent once calibration and beam uncertainties are taken into account, performing a series of statistical tests. With a few minor caveats, our answer is yes, and we compress all data into a single set of 24 bandpowers with associated covariance matrix and window functions. We then compute joint constraints on the 11 parameters of the 'standard' adiabatic inflationary cosmological model. Our best fit model passes a series of physical consistency checks and agrees with essentially all currently available cosmological data. In addition to sharp constraints on the cosmic matter budget in good agreement with those of the BOOMERaNG, DASI and Maxima teams, we obtain a heaviest neutrino mass range 0.04-4.2 eV and the sharpest constraints to date on gravity waves which (together with preference for a slight red-tilt) favor 'small-field' inflation models

  7. Quasars and cosmology

    International Nuclear Information System (INIS)

    Fliche, H.-H.; Souriau, J.-M.

    1978-03-01

    On the basis of colorimetric data a composite spectrum of quasars is established from the visible to the Lyman's limit. Its agreement with the spectrum of the quasar 3C273, obtained directly, confirms the homogeneity of these objects. The compatibility of the following hypotheses: negligible evolution of quasars, Friedmann type model of the universe with cosmological constant, is studied by means of two tests: a non-correlation test adopted to the observation conditions and the construction of diagrams (absolute magnitude, volume) using the K-correction deduced from the composite spectrum. This procedure happens to give relatively well-defined values of the parameters; the central values of the density parameter, the reduced curvature and the reduced cosmological constant are: Ω 0 =0.053, k 0 =0.245, lambda-zero=1.19, which correspond to a big bang model, eternally expanding, spatially finite, in which Hubble's parameter H is presently increasing. This model responds well to different cosmological tests: density of matter, diameter of radio sources, age of the universe. Its characteristics suggest various cosmogonic mechanisms, espacially mass formation by growth of empty spherical bubbles [fr

  8. Cosmology and astroparticles

    International Nuclear Information System (INIS)

    Gelmini, Graciela B.

    1996-01-01

    These lectures are devoted to elementary particle physicists and assume the reader has very little or no knowledge of cosmology and astrophysics. After a brief historical introduction to the development of modern cosmology and astro-particles in which the Hot Big Bang model is defined, the Robertson-Walker metric and the dynamics of the Friedmann-Robertson-Walker cosmology are discussed in section 2. In section 3 the main observational features of the Universe are reviewed, including a description of our neighborhood, homogeneity and isotropy, the cosmic background radiation, the expansion, the age and the matter content of the Universe. A brief account of the thermal history of the Universe follows in section 4, and relic abundances are discussed in section 5. Section 6 is devoted to primordial nucleosynthesis, section 7 to structure formation in the Universe and section 8 to the possibility of detection of the dark matter in the halo of our galaxy. In the relevant sections recent developments are included, such as several so called ''crisis'' (the age crisis, the cluster baryon crisis and the nucleosynthesis crisis), and the MACHO events that may constitute the first detection of dark matter in the halo of our galaxy

  9. Cosmology and the Bispectrum

    Energy Technology Data Exchange (ETDEWEB)

    Sefusatti, Emiliano; /Fermilab /CCPP, New York; Crocce, Martin; Pueblas, Sebastian; Scoccimarro, Roman; /CCPP, New York

    2006-04-01

    The present spatial distribution of galaxies in the Universe is non-Gaussian, with 40% skewness in 50 h{sup -1} Mpc spheres, and remarkably little is known about the information encoded in it about cosmological parameters beyond the power spectrum. In this work they present an attempt to bridge this gap by studying the bispectrum, paying particular attention to a joint analysis with the power spectrum and their combination with CMB data. They address the covariance properties of the power spectrum and bispectrum including the effects of beat coupling that lead to interesting cross-correlations, and discuss how baryon acoustic oscillations break degeneracies. They show that the bispectrum has significant information on cosmological parameters well beyond its power in constraining galaxy bias, and when combined with the power spectrum is more complementary than combining power spectra of different samples of galaxies, since non-Gaussianity provides a somewhat different direction in parameter space. In the framework of flat cosmological models they show that most of the improvement of adding bispectrum information corresponds to parameters related to the amplitude and effective spectral index of perturbations, which can be improved by almost a factor of two. Moreover, they demonstrate that the expected statistical uncertainties in {sigma}s of a few percent are robust to relaxing the dark energy beyond a cosmological constant.

  10. Cosmology and unstable nuclei

    International Nuclear Information System (INIS)

    Schramm, D.N.

    1995-01-01

    Primordial nucleosynthesis has established itself as one of the three pillars of Big Bang cosmology. Many of the Big Bang Nucleosynthesis reactions involve unstable nuclei. Hence there is a tight relationship hetween the subject of this conference and cosmology. The prime role of unstable nuclei in cosmology is related to lithium synthesis and the lack of cosmological synthesis of Be and B. These nuclei will thus be focused upon. Nucleosynthesis involves comparing calculated abundances with observed abundances. In general, abundance determinations are dominated by systematic rather than statistical errors, and work on bounding systematics is crucial. The quark-hadron inspired inhomogeneous calculations now unanimously agree that only relatively small variations in Ω b are possible vis-a-vis the homogeneous model; hence the robustness of Ω b ∼0.05 is now apparent. (These calculations depend critically on unstable nuclei.) The above argues that the bulk of the baryons in the universe are not producing visible light. A comparison with the ROSAT cluster data is also shown to be consistent with the standard BBN model. Ω b ∼1 seems to be definitely excluded, so if Ω TOTAL =1, as some recent observations may hint, then non-baryonic dark matter is required. The implications of the recently reported halo microlensing events are discussed. In summary, it is argued that the physics of unstable nuclei affects the fundamental dark matter argument. ((orig.))

  11. Time variable cosmological constants from the age of universe

    International Nuclear Information System (INIS)

    Xu Lixin; Lu Jianbo; Li Wenbo

    2010-01-01

    In this Letter, time variable cosmological constant, dubbed age cosmological constant, is investigated motivated by the fact: any cosmological length scale and time scale can introduce a cosmological constant or vacuum energy density into Einstein's theory. The age cosmological constant takes the form ρ Λ =3c 2 M P 2 /t Λ 2 , where t Λ is the age or conformal age of our universe. The effective equation of state (EoS) of age cosmological constant are w Λ eff =-1+2/3 (√(Ω Λ ))/c and w Λ eff =-1+2/3 (√(Ω Λ ))/c (1+z) when the age and conformal age of universe are taken as the role of cosmological time scales respectively. The EoS are the same as the so-called agegraphic dark energy models. However, the evolution histories are different from the agegraphic ones for their different evolution equations.

  12. A philosophy for big-bang cosmology.

    Science.gov (United States)

    McCrea, W H

    1970-10-03

    According to recent developments in cosmology we seem bound to find a model universe like the observed universe, almost independently of how we suppose it started. Such ideas, if valid, provide fresh justification for the procedures of current cosmological theory.

  13. Superheavy magnetic monopoles and the standard cosmology

    International Nuclear Information System (INIS)

    Turner, M.S.

    1984-10-01

    The superheavy magnetic monopoles predicted to exist in grand unified theories (GUTs) are very interesting obsects, both from the point of view of particle physics, as well as from astrophysics and cosmology. Astrophysical and cosmological considerations have proved to be invaluable in studying the properties of GUT monopoles. Because of the glut of monopoles predicted in the standard cosmology for the simplest GUTs (so many that the Universe should have reached a temperature of 3 0 K at the tender age of approx. = 10,000 yrs), the simplest GUTs and the standard cosmology are not compatible. This is a very important piece of information about physics at unification energies (E greater than or equal to 10 14 GeV) and about the earliest moments (t less than or equal to 10 -34 s) of the Universe. In this talk the author reviews the cosmological consequences of GUT monopoles within the context of the standard hot big bang model. 46 references

  14. Cosmological parameter estimation using Particle Swarm Optimization

    Science.gov (United States)

    Prasad, J.; Souradeep, T.

    2014-03-01

    Constraining parameters of a theoretical model from observational data is an important exercise in cosmology. There are many theoretically motivated models, which demand greater number of cosmological parameters than the standard model of cosmology uses, and make the problem of parameter estimation challenging. It is a common practice to employ Bayesian formalism for parameter estimation for which, in general, likelihood surface is probed. For the standard cosmological model with six parameters, likelihood surface is quite smooth and does not have local maxima, and sampling based methods like Markov Chain Monte Carlo (MCMC) method are quite successful. However, when there are a large number of parameters or the likelihood surface is not smooth, other methods may be more effective. In this paper, we have demonstrated application of another method inspired from artificial intelligence, called Particle Swarm Optimization (PSO) for estimating cosmological parameters from Cosmic Microwave Background (CMB) data taken from the WMAP satellite.

  15. Cosmological parameter estimation using Particle Swarm Optimization

    International Nuclear Information System (INIS)

    Prasad, J; Souradeep, T

    2014-01-01

    Constraining parameters of a theoretical model from observational data is an important exercise in cosmology. There are many theoretically motivated models, which demand greater number of cosmological parameters than the standard model of cosmology uses, and make the problem of parameter estimation challenging. It is a common practice to employ Bayesian formalism for parameter estimation for which, in general, likelihood surface is probed. For the standard cosmological model with six parameters, likelihood surface is quite smooth and does not have local maxima, and sampling based methods like Markov Chain Monte Carlo (MCMC) method are quite successful. However, when there are a large number of parameters or the likelihood surface is not smooth, other methods may be more effective. In this paper, we have demonstrated application of another method inspired from artificial intelligence, called Particle Swarm Optimization (PSO) for estimating cosmological parameters from Cosmic Microwave Background (CMB) data taken from the WMAP satellite

  16. Gravitational corrections to light propagation in a perturbed FLRW universe and corresponding weak-lensing spectra

    Science.gov (United States)

    Cuesta-Lazaro, Carolina; Quera-Bofarull, Arnau; Reischke, Robert; Schäfer, Björn Malte

    2018-06-01

    When the gravitational lensing of the large-scale structure is calculated from a cosmological model a few assumptions enter: (i) one assumes that the photons follow unperturbed background geodesics, which is usually referred to as the Born approximation, (ii) the lenses move slowly, (iii) the source-redshift distribution is evaluated relative to the background quantities, and (iv) the lensing effect is linear in the gravitational potential. Even though these approximations are small individually they could sum up, especially since they include local effects such as the Sachs-Wolfe and peculiar motion, but also non-local ones like the Born approximation and the integrated Sachs-Wolfe effect. In this work, we will address all points mentioned and perturbatively calculate the effect on a tomographic cosmic shear power spectrum of each effect individually as well as all cross-correlations. Our findings show that each effect is at least 4-5 orders of magnitude below the leading order lensing signal. Finally, we sum up all effects to estimate the overall impact on parameter estimation by a future cosmological weak-lensing survey such as Euclid in a wcold dark matter cosmology with parametrization Ωm, σ8, ns, h, w0, and wa, using five tomographic bins. We consistently find a parameter bias of 10-5, which is therefore completely negligible for all practical purposes, confirming that other effects such as intrinsic alignments, magnification bias and uncertainties in the redshift distribution will be the dominant systematic source in future surveys.

  17. Stepping out of homogeneity in loop quantum cosmology

    International Nuclear Information System (INIS)

    Rovelli, Carlo; Vidotto, Francesca

    2008-01-01

    We explore the extension of quantum cosmology outside the homogeneous approximation using the formalism of loop quantum gravity. We introduce a model where some of the inhomogeneous degrees of freedom are present, providing a tool for describing general fluctuations of quantum geometry near the initial singularity. We show that the dynamical structure of the model reduces to that of loop quantum cosmology in the Born-Oppenheimer approximation. This result corroborates the assumptions that ground loop cosmology sheds some light on the physical and mathematical relation between loop cosmology and full loop quantum gravity, and on the nature of the cosmological approximation. Finally, we show that the non-graph-changing Hamiltonian constraint considered in the context of algebraic quantum gravity provides a viable effective dynamics within this approximation

  18. Cosmology between Physics and Philosophy--Galileo to Einstein

    Science.gov (United States)

    Büttner, J.; Renn, J.

    2008-06-01

    The intention of the present paper is to illuminate, using the example of cosmology, some of the general processes and mechanisms involved in the development of knowledge. Rather than getting immersed in the details of the advancement of cosmological theories, we will concentrate instead on the wider context in which scientific knowledge develops. From its inception, cosmological knowledge in particular has been integrated into comprehensive worldviews. Such worldviews in turn imposed challenges on science and especially on cosmology, and, in a reciprocal development, scientific challenges were incorporated into the formation of comprehensive worldviews as presented in particular by religion. Besides this negotiation process with existing worldviews, technological challenges will be identified as another mainspring that, mediated by cultural contexts, contributed substantially to the development of cosmological knowledge.

  19. Modified General Relativity and Cosmology

    Science.gov (United States)

    Abdel-Rahman, A.-M. M.

    1997-10-01

    Aspects of the modified general relativity theory of Rastall, Al-Rawaf and Taha are discussed in both the radiation- and matter-dominated flat cosmological models. A nucleosynthesis constraint on the theory's free parameter is obtained and the implication for the age of the Universe is discussed. The consistency of the modified matter- dominated model with the neoclassical cosmological tests is demonstrated.

  20. Vignettes in Gravitation and Cosmology

    CERN Document Server

    Sriramkumar, L

    2012-01-01

    This book comprises expository articles on different aspects of gravitation and cosmology that are aimed at graduate students. The topics discussed are of contemporary interest assuming only an elementary introduction to gravitation and cosmology. The presentations are to a certain extent pedagogical in nature, and the material developed is not usually found in sufficient detail in recent textbooks in these areas.

  1. Cosmological monopoles and non-Abelian black holes

    International Nuclear Information System (INIS)

    Brihaye, Yves; Hartmann, Betti; Radu, Eugen; Stelea, Cristian

    2007-01-01

    We discuss magnetic monopole solutions of the Einstein-Yang-Mills-Higgs equations with a positive cosmological constant. These configurations approach asymptotically the de Sitter spacetime background and exist only for a nonzero Higgs potential. We find that the total mass of the solutions within the cosmological horizon is finite. However, their mass evaluated by using the surface counterterm method outside the cosmological horizon at early/late time infinity generically diverges. Magnetic monopole solutions with finite mass and non-integer charge exist however in a truncation of the theory with a vanishing Higgs field. Both solutions with a regular origin and cosmological black holes are studied, special attention being paid to the computation of the global charges

  2. Second viscosity effects in cosmology

    International Nuclear Information System (INIS)

    Potupa, A.S.

    1978-01-01

    The object of the investigation is to draw attention to two important aspects in the choice of a substance model, namely an allowance for the viscosity and behaviour of the metrics at the later stages of cosmological evolution. It is shown that in homogeneous cosmological models taking into account the viscosity there are solutions which realize interpolation between the Fridman and steady-state regimes. In a closed model a solution is obtained which corresponds to the ''curvature compensation'' regime with an unboundedly increasing radius. The problem of compensation of singularity at t → o is discussed as well as the choice of the equations of state for the early (hadron) stages of cosmological evolution in connection with the hydrodynamic theory of multiple hadron production

  3. Wormholes and the cosmological constant problem.

    Science.gov (United States)

    Klebanov, I.

    The author reviews the cosmological constant problem and the recently proposed wormhole mechanism for its solution. Summation over wormholes in the Euclidean path integral for gravity turns all the coupling parameters into dynamical variables, sampled from a probability distribution. A formal saddle point analysis results in a distribution with a sharp peak at the cosmological constant equal to zero, which appears to solve the cosmological constant problem. He discusses the instabilities of the gravitational Euclidean path integral and the difficulties with its interpretation. He presents an alternate formalism for baby universes, based on the "third quantization" of the Wheeler-De Witt equation. This approach is analyzed in a minisuperspace model for quantum gravity, where it reduces to simple quantum mechanics. Once again, the coupling parameters become dynamical. Unfortunately, the a priori probability distribution for the cosmological constant and other parameters is typically a smooth function, with no sharp peaks.

  4. Nonsingular cosmology from evolutionary quantum gravity

    Science.gov (United States)

    Cianfrani, Francesco; Montani, Giovanni; Pittorino, Fabrizio

    2014-11-01

    We provide a cosmological implementation of the evolutionary quantum gravity, describing an isotropic Universe, in the presence of a negative cosmological constant and a massive (preinflationary) scalar field. We demonstrate that the considered Universe has a nonsingular quantum behavior, associated to a primordial bounce, whose ground state has a high occupation number. Furthermore, in such a vacuum state, the super-Hamiltonian eigenvalue is negative, corresponding to a positive emerging dust energy density. The regularization of the model is performed via a polymer quantum approach to the Universe scale factor and the proper classical limit is then recovered, in agreement with a preinflationary state of the Universe. Since the dust energy density is redshifted by the Universe de Sitter phase and the cosmological constant does not enter the ground state eigenvalue, we get a late-time cosmology, compatible with the present observations, endowed with a turning point in the far future.

  5. Repulsive and attractive timelike singularities in vacuum cosmologies

    International Nuclear Information System (INIS)

    Miller, B.D.

    1979-01-01

    Spherically symmetric cosmologies whose big bang is partially spacelike and partially timelike are constrained to occur only in the presence of certain types of matter, and in such cosmologies the timelike part of the big bang is a negative-mass singularity. In this paper examples are given of cylindrically symmetric cosmologies whose big bang is partially spacelike and partially timelike. These cosmologies are vacuum. In some of them, the timelike part of the big bang is clearly a (generalized) negative-mass singularity, while in others it is a (generalized) positive-mass singularity

  6. The cosmological constant in theories with finite spacetime

    International Nuclear Information System (INIS)

    Kummer, Janis

    2014-08-01

    We study the role of the cosmological constant in different theories with finite spacetime. The cosmological constant appears both as an initial condition and as a constant of integration. In the context of the cosmological constant problem a new model will be presented. This modification of general relativity generates a small, non-vanishing cosmological constant, which is radiatively stable. The dynamics of the expansion of the universe in this model will be analyzed. Eventually, we try to solve the emergent problems concerning the generation of accelerated expansion using a quintessence model of dark energy.

  7. Cosmological D-instantons and cyclic universes

    NARCIS (Netherlands)

    Bergshoeff, EA; Collinucci, A; Roest, D; Russo, JG; Townsend, PK

    2005-01-01

    For models of gravity coupled to hyperbolic sigma models, such as the metric-scalar sector of IIB supergravity, we show how smooth trajectories in the 'augmented target space' connect FLRW cosmologies to non-extremal D-instantons through a cosmological singularity. In particular, we find closed

  8. Physically self-consistent basis for modern cosmology

    International Nuclear Information System (INIS)

    Khlopov, M.Yu.

    2000-01-01

    Cosmoparticle physics appeared as a natural result of internal development of cosmology seeking physical grounds for inflation, baryosynthesis, and nonbaryonic dark matter and of particle physics going outside the Standard Model of particle interactions. Its aim is to study the foundations of particle physics and cosmology and their fundamental relationship in the combination of respective indirect cosmological, astrophysical, and physical effects. The ideas on new particles and fields predicted by particle theory and on their cosmological impact are discussed, as well as the methods of cosmoparticle physics to probe these ideas, are considered with special analysis of physical mechanisms for inflation, baryosynthesis, and nonbaryonic dark matter. These mechanisms are shown to reflect the main principle of modern cosmology, putting, instead of formal parameters of cosmological models, physical processes governing the evolution of the big-bang universe. Their realization on the basis of particle theory induces additional model-dependent predictions, accessible to various methods of nonaccelerator particle physics. Probes for such predictions, with the use of astrophysical data, are the aim of cosmoarcheology studying astrophysical effects of new physics. The possibility of finding quantitatively definite relationships between cosmological and laboratory effects on the basis of cosmoparticle approach, as well as of obtaining a unique solution to the problem of physical candidates for inflation, mechanisms of baryogenesis, and multicomponent dark matter, is exemplified in terms of gauge model with broken family symmetry, underlying horizontal unification and possessing quantitatively definite physical grounds for inflation, baryosynthesis, and effectively multicomponent dark-matter scenarios

  9. Observational constraints on cosmological future singularities

    International Nuclear Information System (INIS)

    Beltran Jimenez, Jose; Lazkoz, Ruth; Saez-Gomez, Diego; Salzano, Vincenzo

    2016-01-01

    In this work we consider a family of cosmological models featuring future singularities. This type of cosmological evolution is typical of dark energy models with an equation of state violating some of the standard energy conditions (e.g. the null energy condition). Such a kind of behavior, widely studied in the literature, may arise in cosmologies with phantom fields, theories of modified gravity or models with interacting dark matter/dark energy. We briefly review the physical consequences of these cosmological evolution regarding geodesic completeness and the divergence of tidal forces in order to emphasize under which circumstances the singularities in some cosmological quantities correspond to actual singular spacetimes. We then introduce several phenomenological parameterizations of the Hubble expansion rate to model different singularities existing in the literature and use SN Ia, BAO and H(z) data to constrain how far in the future the singularity needs to be (under some reasonable assumptions on the behavior of the Hubble factor). We show that, for our family of parameterizations, the lower bound for the singularity time cannot be smaller than about 1.2 times the age of the universe, what roughly speaking means ∝2.8 Gyrs from the present time. (orig.)

  10. Constraining holographic cosmology using Planck data

    Science.gov (United States)

    Afshordi, Niayesh; Gould, Elizabeth; Skenderis, Kostas

    2017-06-01

    Holographic cosmology offers a novel framework for describing the very early Universe in which cosmological predictions are expressed in terms of the observables of a three-dimensional quantum field theory (QFT). This framework includes conventional slow-roll inflation, which is described in terms of a strongly coupled QFT, but it also allows for qualitatively new models for the very early Universe, where the dual QFT may be weakly coupled. The new models describe a universe which is nongeometric at early times. While standard slow-roll inflation leads to a (near-) power-law primordial power spectrum, perturbative super-renormalizable QFTs yield a new holographic spectral shape. Here, we compare the two predictions against cosmological observations. We use CosmoMC to determine the best fit parameters, and MultiNest for Bayesian evidence, comparing the likelihoods. We find that the dual QFT should be nonperturbative at the very low multipoles (l ≲30 ), while for higher multipoles (l ≳30 ) the new holographic model, based on perturbative QFT, fits the data just as well as the standard power-law spectrum assumed in Λ CDM cosmology. This finding opens the door to applications of nonperturbative QFT techniques, such as lattice simulations, to observational cosmology on gigaparsec scales and beyond.

  11. Observational constraints on cosmological future singularities

    Energy Technology Data Exchange (ETDEWEB)

    Beltran Jimenez, Jose [Aix Marseille Univ, Universite de Toulon CNRS, CPT, Marseille (France); Lazkoz, Ruth [Euskal Herriko Unibertsitatea, Fisika Teorikoaren eta Zientziaren Historia Saila, Zientzia eta Teknologia Fakultatea, Bilbao (Spain); Saez-Gomez, Diego [Faculdade de Ciencias da Universidade de Lisboa, Departamento de Fisica, Instituto de Astrofisica e Ciencias do Espaco, Lisbon (Portugal); Salzano, Vincenzo [University of Szczecin, Institute of Physics, Szczecin (Poland)

    2016-11-15

    In this work we consider a family of cosmological models featuring future singularities. This type of cosmological evolution is typical of dark energy models with an equation of state violating some of the standard energy conditions (e.g. the null energy condition). Such a kind of behavior, widely studied in the literature, may arise in cosmologies with phantom fields, theories of modified gravity or models with interacting dark matter/dark energy. We briefly review the physical consequences of these cosmological evolution regarding geodesic completeness and the divergence of tidal forces in order to emphasize under which circumstances the singularities in some cosmological quantities correspond to actual singular spacetimes. We then introduce several phenomenological parameterizations of the Hubble expansion rate to model different singularities existing in the literature and use SN Ia, BAO and H(z) data to constrain how far in the future the singularity needs to be (under some reasonable assumptions on the behavior of the Hubble factor). We show that, for our family of parameterizations, the lower bound for the singularity time cannot be smaller than about 1.2 times the age of the universe, what roughly speaking means ∝2.8 Gyrs from the present time. (orig.)

  12. Cosmology without a beginning

    CERN Multimedia

    CERN. Geneva

    2000-01-01

    Most of the puzzles with standard big bang cosmology can be avoided if the big bang is NOT identified with the beginning of time. The short-distance cutoff and duality symmetries of superstring theory suggest a new (so-called pre-big bang) cosmology in which the birth of our Universe is the result of a long classical evolution characterized by a gravitational instability. I will motivate and describe this heretical scenario and compare its phenomenological implications with those of ortodox (post-big bang) inflation.

  13. Non equilibrium relativistic cosmology

    International Nuclear Information System (INIS)

    Novello, M.; Salim, J.M.

    1982-01-01

    A certain systematization through the discussion of results already known on cosmology and the presentation of new ones is given. In section 2 a brief review of the necessary mathematical background is also given. The theory of perturbation of Friedmann-like Universes is presented in section 3. The reduction of Einstein's equations for homogeneous Universes to an autonomous planar system of differential equations is done in section 4. Finally in section 5 the alternative gravitational non-minimal coupling and its consequences to cosmology are discussed. (Author) [pt

  14. Wave packets in quantum cosmology and the cosmological constant

    International Nuclear Information System (INIS)

    Kiefer, C.

    1990-01-01

    Wave packets are constructed explicitly in minisuperspace of quantum gravity corresponding to a Friedmann universe containing a conformally coupled scalar field with and without a cosmological constant. The construction is performed in close analogy to the case of constructing coherent states in quantum mechanics. Various examples are also depicted numerically. The corresponding lorentzian path integrals are evaluated for some cases. It is emphasized that the new concept of time in quantum gravity demands the imposition of a kind of boundary conditions not encountered in quantum gravity demands the imposition of a kind of boundary conditions not encountered in quantum mechanics. Connection is also made to recent investigations predicting a vanishing cosmological constant. It is shown that the fact of whether this result is generic or not depends on where the boundary conditions are imposed in the configuration space. (orig.)

  15. Cosmological tests of coupled Galileons

    International Nuclear Information System (INIS)

    Brax, Philippe; Burrage, Clare; Davis, Anne-Christine; Gubitosi, Giulia

    2015-01-01

    We investigate the cosmological properties of Galileon models which admit Minkowski space as a stable solution in vacuum. This is motivated by stable, positive tension brane world constructions that give rise to Galileons. We include both conformal and disformal couplings to matter and focus on constraints on the theory that arise because of these couplings. The disformal coupling to baryonic matter is extremely constrained by astrophysical and particle physics effects. The disformal coupling to photons induces a cosmological variation of the speed of light and therefore distorsions of the Cosmic Microwave Background spectrum which are known to be very small. The conformal coupling to baryons leads to a variation of particle masses since Big Bang Nucleosynthesis which is also tightly constrained. We consider the background cosmology of Galileon models coupled to Cold Dark Matter (CDM), photons and baryons and impose that the speed of light and particle masses respect the observational bounds on cosmological time scales. We find that requiring that the equation of state for the Galileon models must be close to -1 now restricts severely their parameter space and can only be achieved with a combination of the conformal and disformal couplings. This leads to large variations of particle masses and the speed of light which are not compatible with observations. As a result, we find that cosmological Galileon models are viable dark energy theories coupled to dark matter but their couplings, both disformal and conformal, to baryons and photons must be heavily suppressed making them only sensitive to CDM

  16. Quantum cosmology on the worldsheet

    International Nuclear Information System (INIS)

    Cooper, A.R.; Susskind, L.; Thorlacius, L.

    1991-08-01

    Two-dimensional quantum gravity coupled to conformally invariant matter central c > 25 provides a toy model for quantum gravity in four dimensions. Two-dimensional quantum cosmology can thus be studied in terms of string theory in background fields. The large scale cosmological constant depends on non-linear dynamics in the string theory target space and does not appear to be suppressed by wormhole effects. 13 refs

  17. The cosmology/particle physics interface

    International Nuclear Information System (INIS)

    Olive, K.A.; Schramm, D.N.

    1985-01-01

    The paper reviews the interface between elementary particle physics and cosmology; and concentrates on inflation and the dark matter problem. Inflationary models of the Universe are examined, including phase transitions and supergravity. The three classes of dark matter problems discussed are: dynamical halos, galaxy formation and clustering, and the Ω=1 of inflation. Possible solutions to the cosmological dark matter problems are considered. (U.K.)

  18. BOOK REVIEW: Black Holes, Cosmology and Extra Dimensions Black Holes, Cosmology and Extra Dimensions

    Science.gov (United States)

    Frolov, Valeri P.

    2013-10-01

    The book Black holes, Cosmology and Extra Dimensions written by Kirill A Bronnikov and Sergey G Rubin has been published recently by World Scientific Publishing Company. The authors are well known experts in gravity and cosmology. The book is a monograph, a considerable part of which is based on the original work of the authors. Their original point of view on some of the problems makes the book quite interesting, covering a variety of important topics of the modern theory of gravity, astrophysics and cosmology. It consists of 11 chapters which are organized in three parts. The book starts with an introduction, where the authors briefly discuss the main ideas of General Relativity, giving some historical remarks on its development and application to cosmology, and mentioning some more recent subjects such as brane worlds, f(R)-theories and gravity in higher dimensions. Part I of the book is called 'Gravity'. Chapters two and three are devoted to the Einstein equations and their spherical symmetric black hole solutions. This material is quite standard and can be found in practically any book on General Relativity. A brief summary of the Kerr metric and black hole thermodynamics are given in chapter four. The main part of this chapter is devoted to spherically symmetric black holes in non-Einstein gravity (with scalar and phantom fields), black holes with regular interior, and black holes in brane worlds. Chapters five and six are mainly dedicated to wormholes and the problem of their stability. Part II (Cosmology) starts with discussion of the Friedmann-Robertson-Walker and de Sitter solutions of the Einstein equations and their properties. It follows by describing a `big picture' of the modern cosmology (inflation, post-inflationary reheating, the radiation-dominated and matter-dominated states, and modern stage of the (secondary) inflation). The authors explain how the inflation models allow one to solve many of the long-standing problems of cosmology, such as

  19. On special relativity with cosmological constant

    International Nuclear Information System (INIS)

    Guo Hanying; Huang Chaoguang; Xu Zhan; Zhou Bin

    2004-01-01

    Based on the principle of relativity and the postulate of invariant speed and length, we propose the theory of special relativity with cosmological constant SRc,R, in which the cosmological constant is linked with the invariant length. Its relation with the doubly special relativity is briefly mentioned

  20. FRW Cosmological Perturbations in Massive Bigravity

    CERN Document Server

    Comelli, D; Pilo, L

    2014-01-01

    Cosmological perturbations of FRW solutions in ghost free massive bigravity, including also a second matter sector, are studied in detail. At early time, we find that sub horizon exponential instabilities are unavoidable and they lead to a premature departure from the perturbative regime of cosmological perturbations.

  1. Microphysics, cosmology, and high energy astrophysics

    International Nuclear Information System (INIS)

    Hoyle, F.

    1974-01-01

    The discussion of microphysics, cosmology, and high energy astrophysics includes particle motion in an electromagnetic field, conformal transformations, conformally invariant theory of gravitation, particle orbits, Friedman models with k = 0, +-1, the history and present status of steady-state cosmology, and the nature of mass. (U.S.)

  2. Cosmological evidence for leptonic asymmetry after Planck

    Energy Technology Data Exchange (ETDEWEB)

    Caramete, A.; Popa, L.A., E-mail: acaramete@spacescience.ro, E-mail: lpopa@spacescience.ro [Institute of Space Science, 409 Atomistilor Street, Magurele, Ilfov 077125 (Romania)

    2014-02-01

    Recently, the PLANCK satellite found a larger and most precise value of the matter energy density, that impacts on the present values of other cosmological parameters such as the Hubble constant H{sub 0}, the present cluster abundances S{sub 8}, and the age of the Universe t{sub U}. The existing tension between PLANCK determination of these parameters in the frame of the base ΛCDM model and their determination from other measurements generated lively discussions, one possible interpretation being that some sources of systematic errors in cosmological measurements are not completely understood. An alternative interpretation is related to the fact that the CMB observations, that probe the high redshift Universe are interpreted in terms of cosmological parameters at present time by extrapolation within the base ΛCDM model that can be inadequate or incomplete. In this paper we quantify this tension by exploring several extensions of the base ΛCDM model that include the leptonic asymmetry. We set bounds on the radiation content of the Universe and neutrino properties by using the latest cosmological measurements, imposing also self-consistent BBN constraints on the primordial helium abundance. For all asymmetric cosmological models we find the preference of cosmological data for smaller values of active and sterile neutrino masses. This increases the tension between cosmological and short baseline neutrino oscillation data that favors a sterile neutrino with the mass of around 1 eV. For the case of degenerate massive neutrinos, we find that the discrepancies with the local determinations of H{sub 0}, and t{sub U} are alleviated at ∼ 1.3σ level while S{sub 8} is in agreement with its determination from CFHTLenS survey data at ∼ 1σ and with the prediction of cluster mass-observation relation at ∼ 0.5σ. We also find 2σ statistical preference of the cosmological data for the leptonic asymmetric models involving three massive neutrino species and neutrino direct

  3. Quantum cosmology of classically constrained gravity

    International Nuclear Information System (INIS)

    Gabadadze, Gregory; Shang Yanwen

    2006-01-01

    In [G. Gabadadze, Y. Shang, hep-th/0506040] we discussed a classically constrained model of gravity. This theory contains known solutions of General Relativity (GR), and admits solutions that are absent in GR. Here we study cosmological implications of some of these new solutions. We show that a spatially-flat de Sitter universe can be created from 'nothing'. This universe has boundaries, and its total energy equals to zero. Although the probability to create such a universe is exponentially suppressed, it favors initial conditions suitable for inflation. Then we discuss a finite-energy solution with a nonzero cosmological constant and zero space-time curvature. There is no tunneling suppression to fluctuate into this state. We show that for a positive cosmological constant this state is unstable-it can rapidly transition to a de Sitter universe providing a new unsuppressed channel for inflation. For a negative cosmological constant the space-time flat solutions is stable.

  4. Questions of Modern Cosmology Galileo's Legacy

    CERN Document Server

    D'Onofrio, Mauro

    2009-01-01

    Are we living in the "golden age" of cosmology? Are we close to understanding the nature of the unknown ingredients of the currently most accepted cosmological model and the physics of the early Universe? Or are we instead approaching a paradigm shift? What is dark matter and does it exist? How is it distributed around galaxies and clusters? Is the scientific community open to alternative ideas that may prompt a new scientific revolution - as the Copernican revolution did in Galileo's time? Do other types of supernovae exist that can be of interest for cosmology? Why have quasars never been effectively used as standard candles? Can you tell us about the scientific adventure of COBE? How does the extraction of the Cosmic Microwave Background anisotropy depend on the subtraction of the various astrophysical foregrounds? These, among many others, are the astrophysical, philosophical and sociological questions surrounding modern cosmology and the scientific community that Mauro D'Onofrio and Carlo Burigana pose t...

  5. Cosmology in Poincaré gauge gravity with a pseudoscalar torsion

    Energy Technology Data Exchange (ETDEWEB)

    Lu, Jianbo; Chee, Guoying [Department of Physics, Liaoning Normal University,Dalian 116029 (China)

    2016-05-04

    A cosmology of Poincare{sup ´} gauge theory is developed, where several properties of universe corresponding to the cosmological equations with the pseudoscalar torsion function are investigated. The cosmological constant is found to be the intrinsic torsion and curvature of the vacuum universe and is derived from the theory naturally rather than added artificially, i.e. the dark energy originates from geometry and includes the cosmological constant but differs from it. The cosmological constant puzzle, the coincidence and fine tuning problem are relieved naturally at the same time. By solving the cosmological equations, the analytic cosmological solution is obtained and can be compared with the ΛCDM model. In addition, the expressions of density parameters of the matter and the geometric dark energy are derived, and it is shown that the evolution of state equations for the geometric dark energy agrees with the current observational data. At last, the full equations of linear cosmological perturbations and the solutions are obtained.

  6. Nonlocal teleparallel cosmology.

    Science.gov (United States)

    Bahamonde, Sebastian; Capozziello, Salvatore; Faizal, Mir; Nunes, Rafael C

    2017-01-01

    Even though it is not possible to differentiate general relativity from teleparallel gravity using classical experiments, it could be possible to discriminate between them by quantum gravitational effects. These effects have motivated the introduction of nonlocal deformations of general relativity, and similar effects are also expected to occur in teleparallel gravity. Here, we study nonlocal deformations of teleparallel gravity along with its cosmological solutions. We observe that nonlocal teleparallel gravity (like nonlocal general relativity) is consistent with the present cosmological data obtained by SNe Ia + BAO + CC + [Formula: see text] observations. Along this track, future experiments probing nonlocal effects could be used to test whether general relativity or teleparallel gravity gives the most consistent picture of gravitational interaction.

  7. Nonlocal teleparallel cosmology

    Energy Technology Data Exchange (ETDEWEB)

    Bahamonde, Sebastian [University College London, Department of Mathematics, London (United Kingdom); Capozziello, Salvatore [Universita di Napoli ' ' Federico II' ' , Dipartimento di Fisica ' ' E. Pancini' ' , Naples (Italy); Gran Sasso Science Institute, L' Aquila (Italy); Compl. Univ. di Monte S. Angelo, Naples (Italy); INFN, Napoli (Italy); Faizal, Mir [University of British Columbia - Okanagan, Irving K. Barber School of Arts and Sciences, Kelowna, BC (Canada); University of Lethbridge, Department of Physics and Astronomy, Lethbridge, AB (Canada); Nunes, Rafael C. [Universidade Federal de Juiz de Fora, Departamento de Fisica, Juiz de Fora, MG (Brazil)

    2017-09-15

    Even though it is not possible to differentiate general relativity from teleparallel gravity using classical experiments, it could be possible to discriminate between them by quantum gravitational effects. These effects have motivated the introduction of nonlocal deformations of general relativity, and similar effects are also expected to occur in teleparallel gravity. Here, we study nonlocal deformations of teleparallel gravity along with its cosmological solutions. We observe that nonlocal teleparallel gravity (like nonlocal general relativity) is consistent with the present cosmological data obtained by SNe Ia + BAO + CC + H{sub 0} observations. Along this track, future experiments probing nonlocal effects could be used to test whether general relativity or teleparallel gravity gives the most consistent picture of gravitational interaction. (orig.)

  8. Cosmological inflation

    CERN Document Server

    Enqvist, K

    2012-01-01

    The very basics of cosmological inflation are discussed. We derive the equations of motion for the inflaton field, introduce the slow-roll parameters, and present the computation of the inflationary perturbations and their connection to the temperature fluctuations of the cosmic microwave background.

  9. The Atacama Cosmology Telescope: Cosmology from Galaxy Clusters Detected via the Sunyaev-Zel'dovich Effect

    Energy Technology Data Exchange (ETDEWEB)

    Sehgal, Neelima; Trac, Hy; Acquaviva, Viviana; Ade, Peter A.R.; Aguirre, Paula; Amiri, Mandana; Appel, John W.; Barrientos, L.Felipe; Battistelli, Elia S.; Bond, J.Richard; Brown, Ben; Burger, Bryce; Chervenak, Jay; Das, Sudeep; Devlin, Mark J.; Dicker, Simon R.; Doriese, W.Bertrand; Dunkley, Joanna; Dunner, Rolando; Essinger-Hileman, Thomas; Fisher, Ryan P.

    2011-08-18

    We present constraints on cosmological parameters based on a sample of Sunyaev-Zeldovich-selected galaxy clusters detected in a millimeter-wave survey by the Atacama Cosmology Telescope. The cluster sample used in this analysis consists of 9 optically-confirmed high-mass clusters comprising the high-significance end of the total cluster sample identified in 455 square degrees of sky surveyed during 2008 at 148GHz. We focus on the most massive systems to reduce the degeneracy between unknown cluster astrophysics and cosmology derived from SZ surveys. We describe the scaling relation between cluster mass and SZ signal with a 4-parameter fit. Marginalizing over the values of the parameters in this fit with conservative priors gives {sigma}{sub 8} = 0.851 {+-} 0.115 and w = -1.14 {+-} 0.35 for a spatially-flat wCDM cosmological model with WMAP 7-year priors on cosmological parameters. This gives a modest improvement in statistical uncertainty over WMAP 7-year constraints alone. Fixing the scaling relation between cluster mass and SZ signal to a fiducial relation obtained from numerical simulations and calibrated by X-ray observations, we find {sigma}{sub 8} = 0.821 {+-} 0.044 and w = -1.05 {+-} 0.20. These results are consistent with constraints from WMAP 7 plus baryon acoustic oscillations plus type Ia supernoava which give {sigma}{sub 8} = 0.802 {+-} 0.038 and w = -0.98 {+-} 0.053. A stacking analysis of the clusters in this sample compared to clusters simulated assuming the fiducial model also shows good agreement. These results suggest that, given the sample of clusters used here, both the astrophysics of massive clusters and the cosmological parameters derived from them are broadly consistent with current models.

  10. Protogalaxy formation from inhomogeneities in cosmological models

    International Nuclear Information System (INIS)

    Rankin, J.R.

    1977-01-01

    Equations governing the growth of protogalaxies in general homogeneous cosmological models were derived. Both non-relativistic Newtonian theory and general relativistic theory were covered. For the Newtonian case, by means of the concept of comoving Fourier analysis, the perturbation equations became coupled first order ordinary differential equations and were then further simplified. Bonnor's equation of galaxy formation in isotropic Newtonian cosmologies was generalized to anisotropic cases. The growth equations were solved for various background Newtonian models and gravitationally unstable solutions were found. By an approach analogous to Bonnor's non-relativistic approach, a relativistic version of the galaxy growth equation for the homogeneous isotropic cosmologies was derived. Galaxy growth in the anisotropic homogeneous Bianchi type I cosmologies was also considered. The full set of Einstein equations in synchronous coordinates was perturbed then simplified. The resulting equation was discussed in special cases of dust, axial symmetry and Kasner backgrounds. Finally the tetrad equations for perturbations in steady state cosmologies was set up with a view to considering the effect of rotation

  11. Cosmology and Dark Matter

    CERN Document Server

    Tkachev, Igor

    2017-01-01

    This lecture course covers cosmology from the particle physicist perspective. Therefore, the emphasis will be on the evidence for the new physics in cosmological and astrophysical data together with minimal theoretical frameworks needed to understand and appreciate the evidence. I review the case for non-baryonic dark matter and describe popular models which incorporate it. In parallel, the story of dark energy will be developed, which includes accelerated expansion of the Universe today, the Universe origin in the Big Bang, and support for the Inflationary theory in CMBR data.

  12. Difficulties with inflationary cosmology

    International Nuclear Information System (INIS)

    Penrose, R.

    1989-01-01

    According to the author, the idea of inflationary cosmology is an ingenious attempt to solve some of the major puzzles of cosmology, most notably the flatness problem, the homogeneity (horizon) problem, and the monopole problem. The homogeneity problem, in particular, is intimately connected with a largely unappreciated, but profound puzzle presented by the second law of thermodynamics. The author argues that the mechanism of inflation does not, by itself, come to terms with this and consequently, comes nowhere close to providing an understanding of the large-scale homogeneity of the universe

  13. Cosmological phase transitions

    International Nuclear Information System (INIS)

    Kolb, E.W.

    1987-01-01

    If the universe stated from conditions of high temperature and density, there should have been a series of phase transitions associated with spontaneous symmetry breaking. The cosmological phase transitions could have observable consequences in the present Universe. Some of the consequences including the formation of topological defects and cosmological inflation are reviewed here. One of the most important tools in building particle physics models is the use of spontaneous symmetry breaking (SSB). The proposal that there are underlying symmetries of nature that are not manifest in the vacuum is a crucial link in the unification of forces. Of particular interest for cosmology is the expectation that are the high temperatures of the big bang symmetries broken today will be restored, and that there are phase transitions to the broken state. The possibility that topological defects will be produced in the transition is the subject of this section. The possibility that the Universe will undergo inflation in a phase transition will be the subject of the next section. Before discussing the creation of topological defects in the phase transition, some general aspects of high-temperature restoration of symmetry and the development of the phase transition will be reviewed. 29 references, 1 figure, 1 table

  14. Cosmology and astroparticles

    International Nuclear Information System (INIS)

    Gelmini, G.B.

    1996-01-01

    These lectures are devoted to elementary particle physicists and assume the reader has very little or no knowledge of cosmology and astrophysics. After a brief historical introduction to the development of modern cosmology and astro-particles in which the Hot Big Bang model is defined, the Robertson-Walker metric and the dynamics of the Friedmann-Robertson-Walker cosmology are discussed in section 2. In section 3 the main observational features of the Universe are reviewed, including a description of our neighborhood, homogeneity and isotropy, the cosmic background radiation, the expansion, the age and the matter content of the Universe. A brief account of the thermal history of the Universe follows in section 4, and relic abundances are discussed in section 5. Section 6 is devoted to primordial nucleosynthesis, section 7 to structure formation in the Universe and section 8 to the possibility of detection of the dark matter in the halo of our galaxy. In the relevant sections recent developments are included, such as several so called open-quote open-quote crisis close-quote close-quote (the age crisis, the cluster baryon crisis and the nucleosynthesis crisis), and the MACHO events that may constitute the first detection of dark matter in the halo of our galaxy. copyright 1996 American Institute of Physics

  15. Simple inflationary models in Gauss–Bonnet brane-world cosmology

    International Nuclear Information System (INIS)

    Okada, Nobuchika; Okada, Satomi

    2016-01-01

    In light of the recent Planck 2015 results for the measurement of the cosmic microwave background (CMB) anisotropy, we study simple inflationary models in the context of the Gauss–Bonnet (GB) brane-world cosmology. The brane-world cosmological effect modifies the power spectra of scalar and tensor perturbations generated by inflation and causes a dramatic change for the inflationary predictions of the spectral index ( n s ) and the tensor-to-scalar ratio ( r ) from those obtained in the standard cosmology. In particular, the predicted r values in the inflationary models favored by the Planck 2015 results are suppressed due to the GB brane-world cosmological effect, which is in sharp contrast with inflationary scenario in the Randall–Sundrum brane-world cosmology, where the r values are enhanced. Hence, these two brane-world cosmological scenarios are distinguishable. With the dramatic change of the inflationary predictions, the inflationary scenario in the GB brane-world cosmology can be tested by more precise measurements of n s and future observations of the CMB B -mode polarization. (paper)

  16. Simultaneous preimplantation genetic diagnosis for Tay-Sachs and Gaucher disease.

    Science.gov (United States)

    Altarescu, Gheona; Brooks, Barry; Margalioth, Ehud; Eldar Geva, Talia; Levy-Lahad, Ephrat; Renbaum, Paul

    2007-07-01

    Preimplantation genetic diagnosis (PGD) for single gene defects is described for a family in which each parent is a carrier of both Tay-Sachs (TS) and Gaucher disease (GD). A multiplex fluorescent polymerase chain reaction protocol was developed that simultaneously amplified all four familial mutations and 10 informative microsatellite markers. In one PGD cycle, seven blastomeres were analysed, reaching a conclusive diagnosis in six out of seven embryos for TS and in five out of seven embryos for GD. Of the six diagnosed embryos, one was wild type for both TS and GD, and three were wild type for GD and carriers of TS. Two remaining embryos were compound heterozygotes for TS. Two transferable embryos developed into blastocysts (wt/wt and wt GD/carrier TS) and both were transferred on day 5. This single cycle of PGD resulted in a healthy live child. Allele drop-out (ADO) was observed in three of 34 reactions, yielding an 8% ADO rate. The occurrence of ADO in single cell analysis and undetected recombination events are primary causes of misdiagnosis in PGD and emphasize the need to use multiple polymorphic markers. So far as is known, this is the first report of concomitant PGD for two frequent Ashkenazi Jewish recessive disorders.

  17. Cosmology [2011 European School of High-Energy Physics

    Energy Technology Data Exchange (ETDEWEB)

    Rubakov, V A [Moscow, INR (Russian Federation)

    2014-07-01

    In these lectures we first concentrate on the cosmological problems which, hopefully, have to do with the new physics to be probed at the LHC: the nature and origin of dark matter and generation of matter-antimatter asymmetry. We give several examples showing the LHC cosmological potential. These are WIMPs as cold dark matter, gravitinos as warm dark matter, and electroweak baryogenesis as a mechanism for generating matter-antimatter asymmetry. In the remaining part of the lectures we discuss the cosmological perturbations as a tool for studying the epoch preceeding the conventional hot stage of the cosmological evolution.

  18. Nonsingular bouncing cosmologies in light of BICEP2

    International Nuclear Information System (INIS)

    Cai, Yi-Fu; Quintin, Jerome; Saridakis, Emmanuel N.; Wilson-Ewing, Edward

    2014-01-01

    We confront various nonsingular bouncing cosmologies with the recently released BICEP2 data and investigate the observational constraints on their parameter space. In particular, within the context of the effective field approach, we analyze the constraints on the matter bounce curvaton scenario with a light scalar field, and the new matter bounce cosmology model in which the universe successively experiences a period of matter contraction and an ekpyrotic phase. Additionally, we consider three nonsingular bouncing cosmologies obtained in the framework of modified gravity theories, namely the Hořava-Lifshitz bounce model, the f(T) bounce model, and loop quantum cosmology

  19. Astronomy and Cosmology of the Guarani of Southern Brazil

    Science.gov (United States)

    de Mello, Flávia Cristina

    The Guarani Indians in South Brazil have a sophisticated system of thought about the cosmos. Presented here are some elements of their cosmology and cosmogony and the influences of the heavenly bodies in this people's everyday life, which have been collected in ethnographic research in the first decade of the 21st century. The main themes of cosmology and the origin of the Sun, Moon, and Earth are described, approximating this anthropological research to ethnoastronomy and cultural anthropology discussions. This research seeks to analyze comparatively this cosmological concept with other indigenous cosmological systems and to compare them with the Western cosmological system, thus including it in studies of cultural astronomy.

  20. Possible role of Berry phase in inflationary cosmological perturbations

    International Nuclear Information System (INIS)

    Pal, Barun Kumar; Pal, Supratik; Basu, B

    2012-01-01

    Here we have derived a cosmological analogue of Berry phase by obtaining the corresponding wavefunction for the system of inflationary cosmological perturbations solving the Schrodinger equation. We have further shown that cosmological Berry phase can be related inflationary observable parameters. As a result one can, atleast in principle, establish a supplementary probe of inflationary cosmology through the measurement of the associated Berry phase. But we do not make any strong comment on this.

  1. Collision-free gases in spatially homogeneous space-times

    International Nuclear Information System (INIS)

    Maartens, R.; Maharaj, S.D.

    1985-01-01

    The kinematical and dynamical properties of one-component collision-free gases in spatially homogeneous, locally rotationally symmetric (LRS) space-times are analyzed. Following Ray and Zimmerman [Nuovo Cimento B 42, 183 (1977)], it is assumed that the distribution function f of the gas inherits the symmetry of space-time, in order to construct solutions of Liouville's equation. The redundancy of their further assumption that f be based on Killing vector constants of the motion is shown. The Ray and Zimmerman results for Kantowski--Sachs space-time are extended to all spatially homogeneous LRS space-times. It is shown that in all these space-times the kinematic average four-velocity u/sup i/ can be tilted relative to the homogeneous hypersurfaces. This differs from the perfect fluid case, in which only one space-time admits tilted u/sup i/, as shown by King and Ellis [Commun. Math. Phys. 31, 209 (1973)]. As a consequence, it is shown that all space-times admit nonzero acceleration and heat flow, while a subclass admits nonzero vorticity. The stress π/sub i/j is proportional to the shear sigma/sub i/j by virtue of the invariance of the distribution function. The evolution of tilt and the existence of perfect fluid solutions is also discussed

  2. Viscous cosmological models with a variable cosmological term ...

    African Journals Online (AJOL)

    Einstein's field equations for a Friedmann-Lamaitre Robertson-Walker universe filled with a dissipative fluid with a variable cosmological term L described by full Israel-Stewart theory are considered. General solutions to the field equations for the flat case have been obtained. The solution corresponds to the dust free model ...

  3. Chandra Cluster Cosmology Project III: Cosmological Parameter Constraints

    DEFF Research Database (Denmark)

    Vikhlinin, A.; Kravtsov, A. V.; Burenin, R. A.

    2009-01-01

    function evolution to be used as a useful growth of a structure-based dark energy probe. In this paper, we present cosmological parameter constraints obtained from Chandra observations of 37 clusters with langzrang = 0.55 derived from 400 deg2 ROSAT serendipitous survey and 49 brightest z ≈ 0.05 clusters...

  4. Classical and quantum cosmology of minimal massive bigravity

    Energy Technology Data Exchange (ETDEWEB)

    Darabi, F., E-mail: f.darabi@azaruniv.edu; Mousavi, M., E-mail: mousavi@azaruniv.edu

    2016-10-10

    In a Friedmann–Robertson–Walker (FRW) space–time background we study the classical cosmological models in the context of recently proposed theory of nonlinear minimal massive bigravity. We show that in the presence of perfect fluid the classical field equations acquire contribution from the massive graviton as a cosmological term which is positive or negative depending on the dynamical competition between two scale factors of bigravity metrics. We obtain the classical field equations for flat and open universes in the ordinary and Schutz representation of perfect fluid. Focusing on the Schutz representation for flat universe, we find classical solutions exhibiting singularities at early universe with vacuum equation of state. Then, in the Schutz representation, we study the quantum cosmology for flat universe and derive the Schrodinger–Wheeler–DeWitt equation. We find its exact and wave packet solutions and discuss on their properties to show that the initial singularity in the classical solutions can be avoided by quantum cosmology. Similar to the study of Hartle–Hawking no-boundary proposal in the quantum cosmology of de Rham, Gabadadze and Tolley (dRGT) massive gravity, it turns out that the mass of graviton predicted by quantum cosmology of the minimal massive bigravity is large at early universe. This is in agreement with the fact that at early universe the cosmological constant should be large.

  5. Classical and quantum cosmology of minimal massive bigravity

    International Nuclear Information System (INIS)

    Darabi, F.; Mousavi, M.

    2016-01-01

    In a Friedmann–Robertson–Walker (FRW) space–time background we study the classical cosmological models in the context of recently proposed theory of nonlinear minimal massive bigravity. We show that in the presence of perfect fluid the classical field equations acquire contribution from the massive graviton as a cosmological term which is positive or negative depending on the dynamical competition between two scale factors of bigravity metrics. We obtain the classical field equations for flat and open universes in the ordinary and Schutz representation of perfect fluid. Focusing on the Schutz representation for flat universe, we find classical solutions exhibiting singularities at early universe with vacuum equation of state. Then, in the Schutz representation, we study the quantum cosmology for flat universe and derive the Schrodinger–Wheeler–DeWitt equation. We find its exact and wave packet solutions and discuss on their properties to show that the initial singularity in the classical solutions can be avoided by quantum cosmology. Similar to the study of Hartle–Hawking no-boundary proposal in the quantum cosmology of de Rham, Gabadadze and Tolley (dRGT) massive gravity, it turns out that the mass of graviton predicted by quantum cosmology of the minimal massive bigravity is large at early universe. This is in agreement with the fact that at early universe the cosmological constant should be large.

  6. Cosmology in time asymmetric extensions of general relativity

    International Nuclear Information System (INIS)

    Leon, Genly; Saridakis, Emmanuel N.

    2015-01-01

    We investigate the cosmological behavior in a universe governed by time asymmetric extensions of general relativity, which is a novel modified gravity based on the addition of new, time-asymmetric, terms on the Hamiltonian framework, in a way that the algebra of constraints and local physics remain unchanged. Nevertheless, at cosmological scales these new terms can have significant effects that can alter the universe evolution, both at early and late times, and the freedom in the choice of the involved modification function makes the scenario able to produce a huge class of cosmological behaviors. For basic ansatzes of modification, we perform a detailed dynamical analysis, extracting the stable late-time solutions. Amongst others, we find that the universe can result in dark-energy dominated, accelerating solutions, even in the absence of an explicit cosmological constant, in which the dark energy can be quintessence-like, phantom-like, or behave as an effective cosmological constant. Moreover, it can result to matter-domination, or to a Big Rip, or experience the sequence from matter to dark energy domination. Additionally, in the case of closed curvature, the universe may experience a cosmological bounce or turnaround, or even cyclic behavior. Finally, these scenarios can easily satisfy the observational and phenomenological requirements. Hence, time asymmetric cosmology can be a good candidate for the description of the universe

  7. Dark energy cosmologies for codimension-two branes

    International Nuclear Information System (INIS)

    Schwindt, Jan-Markus; Wetterich, Christof

    2005-01-01

    A six-dimensional universe with two branes in the 'football-shaped' geometry leads to an almost realistic cosmology. We describe a family of exact solutions with time-dependent characteristic size of internal space. After a short inflationary period the late cosmology is either of quintessence type or turns to a radiation-dominated Friedmann universe where the cosmological constant appears as a free integration constant of the solution. The radiation-dominated universe with relativistic fermions is analyzed in detail, including its dimensional reduction

  8. Elements of the universe in Philo's De Vita Mosis: Cosmological theology or theological cosmology?

    OpenAIRE

    Steyn, Gert J.

    2013-01-01

    It is the intention of this article to investigate how Philo's understanding of the universe, and particularly its four basic elements as taught by the Greek philosophers, influenced his description of the God of Israel's world in which the Moses narrative unfolds. Given the fact that Philo was a theologian par excellence, the question can be asked whether Philo's approach is closer to what one might call 'theological cosmology' or rather closer to 'cosmological theology'? After a brief surve...

  9. Active packaging for fresh-cut broccoli using 1-methylcyclopropene in biodegradable sachet/ Embalagem ativa para brócolis minimamente processado utilizando 1-metilciclopropeno em sachê biodegradável

    Directory of Open Access Journals (Sweden)

    Marta de Toledo Benassi

    2006-07-01

    Full Text Available Fresh-cut broccoli florets were packed in polypropylene pots containing a sachet with 1- methylcyclopropene (1-MCP and sealed with biodegradable starch-based film. Broccoli was stored for 8 days at 12oC and after this time the color and the texture of the product were similar of the fresh broccoli, with no off-flavor development or decay. Active packaging with 1-MCP in a sachet was efficient to extent shelf life of broccoli florets retarding yellowing and vitamin C losses. It is an alternative of 1-MCP treatment for fresh-cut products and besides, the sachet can absorbs condensed water reducing spoilage and off-odor development.Brócolis minimamente processados foram embalados em bandejas de polipropileno com sachê contendo 1-metilciclopropeno (1-MCP e selado com filme biodegradável de amido. Os brócolis foram armazenados por 8 dias a 12oC e após este tempo a cor e a textura mantiveram-se similares às do produto fresco, sem desenvolvimento de odor não característico ou podridão. A embalagem ativa contendo 1-MCP na forma de sachê foi eficiente no aumento da vida de prateleira de brócolis, retardando o amarelecimento e a perda de vitamina C. Esta é uma alternativa para o tratamento com 1-MCP para produtos minimamente processados e além disso, o sachê pode absorver a água condensada, reduzindo a deterioração e o desenvolvimento de odor não característico.

  10. Christian Nurture and the New Cosmology

    Science.gov (United States)

    Price, Elizabeth Box

    2008-01-01

    Christian Religious Education recognizes the crisis in perception caused by eroding cosmologies and engages persons in the reformulating of Christian stories that negate a limiting materialism perpetuating consumerism destructive to life. A course is developed for theological students in which they may become aware of cosmology and its New Story,…

  11. Cross-correlating CMB temperature fluctuations with high-energy γ-ray from Dark-Matter annihilation

    International Nuclear Information System (INIS)

    Pieri, L.

    2013-01-01

    In this paper we compute the Integrated Sachs-Wolfe effect due to the presence of dark-matter structures on cosmological scale. We cross-correlate the CMB temperature fluctuations with the extragalactic high-energy γ-ray flux map obtained with FERMI-LAT. We find a null signal consistent with the theory and conclude that the presence of halos and subhalos at galactic and extragalactic scale, if not excluded, will be hardly discoverable.

  12. Optical structures, algebraically special spacetimes, and the Goldberg-Sachs theorem in five dimensions

    International Nuclear Information System (INIS)

    Taghavi-Chabert, Arman

    2011-01-01

    Optical (or Robinson) structures are one generalization of four-dimensional shearfree congruences of null geodesics to higher dimensions. They are Lorentzian analogues of complex and CR structures. In this context, we extend the Goldberg-Sachs theorem to five dimensions. To be precise, we find a new algebraic condition on the Weyl tensor, which generalizes the Petrov type II condition, in the sense that it ensures the existence of such congruences on a five-dimensional spacetime, vacuum or under weaker assumptions on the Ricci tensor. This results in a significant simplification of the field equations. We discuss possible degenerate cases, including a five-dimensional generalization of the Petrov type D condition. We also show that the vacuum black ring solution is endowed with optical structures, yet fails to be algebraically special with respect to them. We finally explain the generalization of these ideas to higher dimensions, which has been checked in six and seven dimensions.

  13. Homogenization and isotropization of an inflationary cosmological model

    International Nuclear Information System (INIS)

    Barrow, J.D.; Groen, Oe.; Oslo Univ.

    1986-01-01

    A member of the class of anisotropic and inhomogeneous cosmological models constructed by Wainwright and Goode is investigated. It is shown to describe a universe containing a scalar field which is minimally coupled to gravitation and a positive cosmological constant. It is shown that this cosmological model evolves exponentially rapidly towards the homogeneous and isotropic de Sitter universe model. (orig.)

  14. Cosmological Backgrounds of Gravitational Waves and eLISA

    OpenAIRE

    Dufaux, Jean-Francois

    2012-01-01

    We review cosmological backgrounds of gravitational waves with a particular attention to the scientific potential of the eLISA/NGO mission. After an overview of cosmological backgrounds and detectors, we consider different cosmological sources that could lead to an observable signal. We then study the backgrounds produced by first-order phase transitions and networks of cosmic strings, assessing the prospects for their detection.

  15. Black Holes, Cosmology and Extra Dimensions

    International Nuclear Information System (INIS)

    Frolov, Valeri P

    2013-01-01

    Book review: The book Black holes, Cosmology and Extra Dimensions written by Kirill A Bronnikov and Sergey G Rubin has been published recently by World Scientific Publishing Company. The authors are well known experts in gravity and cosmology. The book is a monograph, a considerable part of which is based on the original work of the authors. Their original point of view on some of the problems makes the book quite interesting, covering a variety of important topics of the modern theory of gravity, astrophysics and cosmology. It consists of 11 chapters which are organized in three parts. The book starts with an introduction, where the authors briefly discuss the main ideas of General Relativity, giving some historical remarks on its development and application to cosmology, and mentioning some more recent subjects such as brane worlds, f (R)−theories and gravity in higher dimensions. Part I of the book is called ‘Gravity’. Chapters two and three are devoted to the Einstein equations and their spherical symmetric black hole solutions. Part II (Cosmology) starts with discussion of the Friedmann–Robertson–Walker and de Sitter solutions of the Einstein equations and their properties. Part III covers the material on extra dimensions. It describes how Einstein gravity is modified in the presence of one or more additional spatial dimensions and how these extra dimensions are compactified in the Kaluza–Klein scheme

  16. Cosmological perturbations in antigravity

    Science.gov (United States)

    Oltean, Marius; Brandenberger, Robert

    2014-10-01

    We compute the evolution of cosmological perturbations in a recently proposed Weyl-symmetric theory of two scalar fields with oppositely signed conformal couplings to Einstein gravity. It is motivated from the minimal conformal extension of the standard model, such that one of these scalar fields is the Higgs while the other is a new particle, the dilaton, introduced to make the Higgs mass conformally symmetric. At the background level, the theory admits novel geodesically complete cyclic cosmological solutions characterized by a brief period of repulsive gravity, or "antigravity," during each successive transition from a big crunch to a big bang. For simplicity, we consider scalar perturbations in the absence of anisotropies, with potential set to zero and without any radiation. We show that despite the necessarily wrong-signed kinetic term of the dilaton in the full action, these perturbations are neither ghostlike nor tachyonic in the limit of strongly repulsive gravity. On this basis, we argue—pending a future analysis of vector and tensor perturbations—that, with respect to perturbative stability, the cosmological solutions of this theory are viable.

  17. Integrated cosmological probes: concordance quantified

    Energy Technology Data Exchange (ETDEWEB)

    Nicola, Andrina; Amara, Adam; Refregier, Alexandre, E-mail: andrina.nicola@phys.ethz.ch, E-mail: adam.amara@phys.ethz.ch, E-mail: alexandre.refregier@phys.ethz.ch [Department of Physics, ETH Zürich, Wolfgang-Pauli-Strasse 27, CH-8093 Zürich (Switzerland)

    2017-10-01

    Assessing the consistency of parameter constraints derived from different cosmological probes is an important way to test the validity of the underlying cosmological model. In an earlier work [1], we computed constraints on cosmological parameters for ΛCDM from an integrated analysis of CMB temperature anisotropies and CMB lensing from Planck, galaxy clustering and weak lensing from SDSS, weak lensing from DES SV as well as Type Ia supernovae and Hubble parameter measurements. In this work, we extend this analysis and quantify the concordance between the derived constraints and those derived by the Planck Collaboration as well as WMAP9, SPT and ACT. As a measure for consistency, we use the Surprise statistic [2], which is based on the relative entropy. In the framework of a flat ΛCDM cosmological model, we find all data sets to be consistent with one another at a level of less than 1σ. We highlight that the relative entropy is sensitive to inconsistencies in the models that are used in different parts of the analysis. In particular, inconsistent assumptions for the neutrino mass break its invariance on the parameter choice. When consistent model assumptions are used, the data sets considered in this work all agree with each other and ΛCDM, without evidence for tensions.

  18. Quantum cosmology from the de Broglie–Bohm perspective

    International Nuclear Information System (INIS)

    Pinto-Neto, N; Fabris, J C

    2013-01-01

    We review the main results that have been obtained in quantum cosmology from the perspective of the de Broglie–Bohm quantum theory. As it is a dynamical theory of assumed objectively real trajectories in the configuration space of the physical system under investigation, this quantum theory is not essentially probabilistic and dispenses the collapse postulate, turning it suitable to be applied to cosmology. In the framework of minisuperspace models, we show how quantum cosmological effects in the de–Broglie-Bohm approach can avoid the initial singularity, and isotropize the Universe. We then extend minisuperspace in order to include linear cosmological perturbations. We present the main equations which govern the dynamics of quantum cosmological perturbations evolving in non-singular quantum cosmological backgrounds, and calculate some of their observational consequences. These results are not known how to be obtained in other approaches to quantum theory. In the general case of full superspace, we enumerate the possible structures of quantum space and time that emerge from the de Broglie–Bohm picture. Finally, we compare some of the results coming from the de Broglie–Bohm theory with other approaches, and discuss the physical reasons for some discrepancies that occur. (topical review)

  19. The expanding Universe a primer on relativistic cosmology

    CERN Document Server

    Heacox, William D

    2015-01-01

    Cosmology - the science of the Universe at large - has experienced a renaissance in the decades bracketing the turn of the twenty-first century. Exploring our emerging understanding of cosmology, this text takes two complementary points of view: the physical principles underlying theories of cosmology, and the observable consequences of models of Universal expansion. The book develops cosmological models based on fundamental physical principles, with mathematics limited to the minimum necessary to keep the material accessible for students of physics and astronomy at the advanced undergraduate level. A substantial review of general relativity leading up to the Einstein field equations is included, with derivations of explicit formulations connecting observable features of the Universe to models of its expansion. Self-contained and up to date in respect of modern observations, the text provides a solid theoretical grounding in modern cosmology while preparing readers for the changes that will inevitably come fr...

  20. Holographic cosmology and its relevant degrees of freedom

    International Nuclear Information System (INIS)

    Dawid, Richard

    1999-01-01

    We reconsider the options for cosmological holography. We suggest that a global and time-symmetric version of the Fischler-Susskind bound is the most natural generalization of the holographic bound encountered in AdS and De Sitter space. A consistent discussion of cosmological holography seems to imply an understanding of the notion of ''number of degrees of freedom'' that deviates from its simple definition as the entropy of the current state. The introduction of a more adequate notion of degree of freedom makes the suggested variation of the Fischler-Susskind bound look like a stringent and viable bound in all 4-dimensional cosmologies without a cosmological constant

  1. Cosmology and convention

    Science.gov (United States)

    Merritt, David

    2017-02-01

    I argue that some important elements of the current cosmological model are 'conventionalist' in the sense defined by Karl Popper. These elements include dark matter and dark energy; both are auxiliary hypotheses that were invoked in response to observations that falsified the standard model as it existed at the time. The use of conventionalist stratagems in response to unexpected observations implies that the field of cosmology is in a state of 'degenerating problemshift' in the language of Imre Lakatos. I show that the 'concordance' argument, often put forward by cosmologists in support of the current paradigm, is weaker than the convergence arguments that were made in the past in support of the atomic theory of matter or the quantization of energy.

  2. Murine Sialidase Neu3 facilitates GM2 degradation and bypass in mouse model of Tay-Sachs disease.

    Science.gov (United States)

    Seyrantepe, Volkan; Demir, Secil Akyildiz; Timur, Zehra Kevser; Von Gerichten, Johanna; Marsching, Christian; Erdemli, Esra; Oztas, Emin; Takahashi, Kohta; Yamaguchi, Kazunori; Ates, Nurselin; Dönmez Demir, Buket; Dalkara, Turgay; Erich, Katrin; Hopf, Carsten; Sandhoff, Roger; Miyagi, Taeko

    2018-01-01

    Tay-Sachs disease is a severe lysosomal storage disorder caused by mutations in Hexa, the gene that encodes for the α subunit of lysosomal β-hexosaminidase A (HEXA), which converts GM2 to GM3 ganglioside. Unexpectedly, Hexa -/- mice have a normal lifespan and show no obvious neurological impairment until at least one year of age. These mice catabolize stored GM2 ganglioside using sialidase(s) to remove sialic acid and form the glycolipid GA2, which is further processed by β-hexosaminidase B. Therefore, the presence of the sialidase (s) allows the consequences of the Hexa defect to be bypassed. To determine if the sialidase NEU3 contributes to GM2 ganglioside degradation, we generated a mouse model with combined deficiencies of HEXA and NEU3. The Hexa -/- Neu3 -/- mice were healthy at birth, but died at 1.5 to 4.5months of age. Thin-layer chromatography and mass spectrometric analysis of the brains of Hexa -/- Neu3 -/- mice revealed the abnormal accumulation of GM2 ganglioside. Histological and immunohistochemical analysis demonstrated cytoplasmic vacuolation in the neurons. Electron microscopic examination of the brain, kidneys and testes revealed pleomorphic inclusions of many small vesicles and complex lamellar structures. The Hexa -/- Neu3 -/- mice exhibited progressive neurodegeneration with neuronal loss, Purkinje cell depletion, and astrogliosis. Slow movement, ataxia, and tremors were the prominent neurological abnormalities observed in these mice. Furthermore, radiographs revealed abnormalities in the skeletal bones of the Hexa -/- Neu3 -/- mice. Thus, the Hexa -/- Neu3 -/- mice mimic the neuropathological and clinical abnormalities of the classical early-onset Tay-Sachs patients, and provide a suitable model for the future pre-clinical testing of potential treatments for this condition. Copyright © 2017 Elsevier Inc. All rights reserved.

  3. Working group report: Cosmology and astroparticle physics

    Indian Academy of Sciences (India)

    This is the report of the cosmology and astroparticle physics working group ... origin of the accelerating Universe: Dark energy and particle cosmology by Y-Y Keum, .... Neutrino oscillations with two and three mass varying supernova neutrinos ...

  4. Cosmological birefringence constraints from CMB and astrophysical polarization data

    Energy Technology Data Exchange (ETDEWEB)

    Galaverni, M. [Studio Teologico Interdiocesano, V.le Timavo 93, Reggio Emilia, 42121 Italy (Italy); Gubitosi, G. [Dipartimento di Fisica and sez. Roma1 INFN, Università di Roma ' La Sapienza' , P.le A. Moro 2, Rome, 00185 Italy (Italy); Paci, F. [SISSA, Scuola Internazionale Superiore di Studi Avanzati, Via Bonomea 265, Trieste, 34136 Italy (Italy); Finelli, F., E-mail: matteo.galaverni@gmail.com, E-mail: giulia.gubitosi@imperial.ac.uk, E-mail: fpaci@sissa.it, E-mail: finelli@iasfbo.inaf.it [INAF-IASF Bologna, via Gobetti 101, Bologna, I-40129 Italy (Italy)

    2015-08-01

    Cosmological birefringence is a rotation of the polarization plane of photons coming from sources of astrophysical and cosmological origin. The rotation can also depend on the energy of the photons and not only on the distance of the source and on the cosmological evolution of the underlying theoretical model. In this work, we constrain few selected models for cosmological birefringence, combining CMB and astrophysical data at radio, optical, X and γ wavelengths, taking into account the specific energy and distance dependences.

  5. Quintom cosmology: Theoretical implications and observations

    International Nuclear Information System (INIS)

    Cai Yifu; Saridakis, Emmanuel N.; Setare, Mohammad R.; Xia Junqing

    2010-01-01

    We review the paradigm of quintom cosmology. This scenario is motivated by the observational indications that the equation-of-state of dark energy across the cosmological constant boundary is mildly favored, although the data are still far from being conclusive. As a theoretical setup we introduce a no-go theorem existing in quintom cosmology, and based on it we discuss the conditions for the equation-of-state of dark energy realizing the quintom scenario. The simplest quintom model can be achieved by introducing two scalar fields with one being quintessence and the other phantom. Based on the double-field quintom model we perform a detailed analysis of dark energy perturbations and we discuss their effects on current observations. This type of scenario usually suffers from a manifest problem due to the existence of a ghost degree-of-freedom, and thus we review various alternative realizations of the quintom paradigm. The developments in particle physics and string theory provide potential clues indicating that a quintom scenario may be obtained from scalar systems with higher derivative terms, as well as from non-scalar systems. Additionally, we construct a quintom realization in the framework of braneworld cosmology, where the cosmic acceleration and the phantom divide crossing result from the combined effects of the field evolution on the brane and the competition between four- and five-dimensional gravity. Finally, we study the outsets and fates of a universe in quintom cosmology. In a scenario with null energy condition violation one may obtain a bouncing solution at early times and therefore avoid the Big Bang singularity. Furthermore, if this occurs periodically, we obtain a realization of an oscillating universe. Lastly, we comment on several open issues in quintom cosmology and their connection to future investigations.

  6. A curious explanation of some cosmological phenomena

    International Nuclear Information System (INIS)

    Vishwakarma, Ram Gopal

    2013-01-01

    Although observational cosmology has shown tremendous growth over the last decade, deep mysteries continue to haunt our theoretical understanding of the ingredients of the concordance cosmological model, which are mainly ‘dark’. More than 95% of the content of the energy–stress tensor has to be in the form of the inflaton field, dark matter and dark energy, which do not have any non-gravitational or laboratory evidence and remain unidentified. Moreover, the dark energy poses a serious confrontation between fundamental physics and cosmology. This makes a strong case to discover alternative theories that do not require the dark sectors of the standard approach to explain the observations. In the present situation, it would be important to gain insight about the requirements of the ‘would-be’ final theory from all possible means. In this context, this paper highlights some, hitherto unnoticed, interesting coincidences that may prove useful to develop insight about the ‘holy grail’ of gravitation. It appears that the requirement of the speculative dark sectors by the energy–stress tensor is indicative of a possible way out of the present crisis appearing in the standard cosmology, in terms of a theory wherein the energy–stress tensor does not play a direct role in the dynamics. It is shown that various cosmological observations can be explained satisfactorily in the framework of one such theory—the Milne model, without requiring the dark sectors of the standard approach. Moreover, the model evades the horizon, flatness and the cosmological constant problems afflicting the standard cosmology. Although Milne's theory is an incomplete, phenomenological theory, and cannot be the final theory of gravitation, nevertheless, it would be worthwhile to study these coincidences, which may help us develop insight about the would-be final theory. (paper)

  7. A curious explanation of some cosmological phenomena

    Science.gov (United States)

    Gopal Vishwakarma, Ram

    2013-05-01

    Although observational cosmology has shown tremendous growth over the last decade, deep mysteries continue to haunt our theoretical understanding of the ingredients of the concordance cosmological model, which are mainly ‘dark’. More than 95% of the content of the energy-stress tensor has to be in the form of the inflaton field, dark matter and dark energy, which do not have any non-gravitational or laboratory evidence and remain unidentified. Moreover, the dark energy poses a serious confrontation between fundamental physics and cosmology. This makes a strong case to discover alternative theories that do not require the dark sectors of the standard approach to explain the observations. In the present situation, it would be important to gain insight about the requirements of the ‘would-be’ final theory from all possible means. In this context, this paper highlights some, hitherto unnoticed, interesting coincidences that may prove useful to develop insight about the ‘holy grail’ of gravitation. It appears that the requirement of the speculative dark sectors by the energy-stress tensor is indicative of a possible way out of the present crisis appearing in the standard cosmology, in terms of a theory wherein the energy-stress tensor does not play a direct role in the dynamics. It is shown that various cosmological observations can be explained satisfactorily in the framework of one such theory—the Milne model, without requiring the dark sectors of the standard approach. Moreover, the model evades the horizon, flatness and the cosmological constant problems afflicting the standard cosmology. Although Milne's theory is an incomplete, phenomenological theory, and cannot be the final theory of gravitation, nevertheless, it would be worthwhile to study these coincidences, which may help us develop insight about the would-be final theory.

  8. Constraints on particle physics from cosmology

    International Nuclear Information System (INIS)

    Schramm, D.N.; Charlton, J.C.

    1986-01-01

    Cosmology and particle physics have become symbiotic in their relationship. In the past, developments in physics have been used to explain astrophysics problems. Recently, cosmology also has been able to place constraints on particle properties and these constraints can be tested by experiment. Thus, the flow of information at the interface of particle physics and cosmology is no longer just one-way. (Astronomy is no longer a parasite of physics.) Many examples of the interchange are described in this review. The timeline of cosmology is rapidly filling in as later events find their explanations in earlier events. In this review, the authors mention what is known about each epoch and show how it might constrain the particle models. Since a great deal of effort is devoted currently to the study of the dark matter problem, special emphasis will be placed on this issue. This study of dark matter and galaxy formation will allow us to draw upon much of what was discussed in earlier epochs. This review draws heavily on a previous review by the authors

  9. Arbitrary scalar-field and quintessence cosmological models

    International Nuclear Information System (INIS)

    Harko, Tiberiu; Lobo, Francisco S.N.; Mak, M.K.

    2014-01-01

    The mechanism of the initial inflationary scenario of the Universe and of its late-time acceleration can be described by assuming the existence of some gravitationally coupled scalar fields φ, with the inflaton field generating inflation and the quintessence field being responsible for the late accelerated expansion. Various inflationary and late-time accelerated scenarios are distinguished by the choice of an effective self-interaction potential V(φ), which simulates a temporarily non-vanishing cosmological term. In this work, we present a new formalism for the analysis of scalar fields in flat isotropic and homogeneous cosmological models. The basic evolution equation of the models can be reduced to a first-order non-linear differential equation. Approximate solutions of this equation can be constructed in the limiting cases of the scalar-field kinetic energy and potential energy dominance, respectively, as well as in the intermediate regime. Moreover, we present several new accelerating and decelerating exact cosmological solutions, based on the exact integration of the basic evolution equation for scalar-field cosmologies. More specifically, exact solutions are obtained for exponential, generalized cosine hyperbolic, and power-law potentials, respectively. Cosmological models with power-law scalar field potentials are also analyzed in detail. (orig.)

  10. Exploring Cosmology with Supernovae

    DEFF Research Database (Denmark)

    Li, Xue

    distribution of strong gravitational lensing is developed. For Type Ia supernova (SNe Ia), the rate is lower than core-collapse supernovae (CC SNe). The rate of SNe Ia declines beyond z 1:5. Based on these reasons, we investigate a potential candidate to measure cosmological distance: GRB......-SNe. They are a subclass of CC SNe. Light curves of GRB-SNe are obtained and their properties are studied. We ascertain that the properties of GRB-SNe make them another candidate for standardizable candles in measuring the cosmic distance. Cosmological parameters M and are constrained with the help of GRB-SNe. The first...

  11. Einstein and modern cosmology

    International Nuclear Information System (INIS)

    Stabell, R.

    1979-01-01

    Einstein applied his gravitation theory to a universe model with positively curved space in 1917. In order to maintain a static universe he introduced the cosmological constant, which in the light of later nonstatic universe models, he described as his life's greatest mistake. The best known such model is the Einstein-de Sitter model, which is here discussed in some detail. The 'big bang' theory is also discussed leading to the cosmic background radiation. The early phase of the 'big bang' cosmology, the first ten seconds, and the first minutes are discussed, leading to the transparent stage. (JIW)

  12. Cosmological models without singularities

    International Nuclear Information System (INIS)

    Petry, W.

    1981-01-01

    A previously studied theory of gravitation in flat space-time is applied to homogeneous and isotropic cosmological models. There exist two different classes of models without singularities: (i) ever-expanding models, (ii) oscillating models. The first class contains models with hot big bang. For these models there exist at the beginning of the universe-in contrast to Einstein's theory-very high but finite densities of matter and radiation with a big bang of very short duration. After short time these models pass into the homogeneous and isotropic models of Einstein's theory with spatial curvature equal to zero and cosmological constant ALPHA >= O. (author)

  13. COSMOLOGICAL ADAPTIVE MESH REFINEMENT MAGNETOHYDRODYNAMICS WITH ENZO

    International Nuclear Information System (INIS)

    Collins, David C.; Xu Hao; Norman, Michael L.; Li Hui; Li Shengtai

    2010-01-01

    In this work, we present EnzoMHD, the extension of the cosmological code Enzo to include the effects of magnetic fields through the ideal magnetohydrodynamics approximation. We use a higher order Godunov method for the computation of interface fluxes. We use two constrained transport methods to compute the electric field from those interface fluxes, which simultaneously advances the induction equation and maintains the divergence of the magnetic field. A second-order divergence-free reconstruction technique is used to interpolate the magnetic fields in the block-structured adaptive mesh refinement framework already extant in Enzo. This reconstruction also preserves the divergence of the magnetic field to machine precision. We use operator splitting to include gravity and cosmological expansion. We then present a series of cosmological and non-cosmological test problems to demonstrate the quality of solution resulting from this combination of solvers.

  14. Development of the Universe and New Cosmology

    CERN Document Server

    Sakharov, Alexander S

    2003-01-01

    Cosmology is undergoing an explosive period of activity, fueled both by new, accurate astrophysical data and by innovative theoretical developments. Cosmological parameters such as the total density of the Universe and the rate of cosmological expansion are being precisely measured for the first time, and a consistent standard picture of the Universe is beginning to emerge. Recent developments in cosmology give rise the intriguing possibility that all structures in the Universe, from superclusters to planets, had a quantum-mechanical origin in its earliest moments. Furthermore, these ideas are not idle theorizing, but predictive, and subject to meaningful experimental test. We review the concordance model of the development of the Universe, as well as evidence for the observational revolution that this field is going through. This already provides us with important information on particle physics, which is inaccessible to accelerators.

  15. The bystander effect model of Brenner and Sachs fitted to lung cancer data in 11 cohorts of underground miners, and equivalence of fit of a linear relative risk model with adjustment for attained age and age at exposure

    International Nuclear Information System (INIS)

    Little, M P

    2004-01-01

    Bystander effects following exposure to α-particles have been observed in many experimental systems, and imply that linearly extrapolating low dose risks from high dose data might materially underestimate risk. Brenner and Sachs (2002 Int. J. Radiat. Biol. 78 593-604; 2003 Health Phys. 85 103-8) have recently proposed a model of the bystander effect which they use to explain the inverse dose rate effect observed for lung cancer in underground miners exposed to radon daughters. In this paper we fit the model of the bystander effect proposed by Brenner and Sachs to 11 cohorts of underground miners, taking account of the covariance structure of the data and the period of latency between the development of the first pre-malignant cell and clinically overt cancer. We also fitted a simple linear relative risk model, with adjustment for age at exposure and attained age. The methods that we use for fitting both models are different from those used by Brenner and Sachs, in particular taking account of the covariance structure, which they did not, and omitting certain unjustifiable adjustments to the miner data. The fit of the original model of Brenner and Sachs (with 0 y period of latency) is generally poor, although it is much improved by assuming a 5 or 6 y period of latency from the first appearance of a pre-malignant cell to cancer. The fit of this latter model is equivalent to that of a linear relative risk model with adjustment for age at exposure and attained age. In particular, both models are capable of describing the observed inverse dose rate effect in this data set

  16. Planck 2013 Cosmology Results: a Review

    Directory of Open Access Journals (Sweden)

    José Alberto Rubino-Martín

    2014-12-01

    Full Text Available This talk presents an overview of the cosmological results derived from the first 15.5 months of observations of the ESA’s Planck mission. These cosmological results are mainly based on the Planck measurements of the cosmic microwave background (CMB temperature and lensing-potential power spectra, although we also briefly discuss other aspects of the Planck data, as the statistical characterization of the reconstructed CMB maps, or the constraints on cosmological parameters using the number counts of galaxy clusters detected by means of the Sunyaev-Zeldovich effect in the Planck maps. All these results are described in detail in a series of papers released by ESA and the Planck collaboration in March 2013.

  17. Cosmological evolution of p-brane networks

    International Nuclear Information System (INIS)

    Sousa, L.; Avelino, P. P.

    2011-01-01

    In this paper we derive, directly from the Nambu-Goto action, the relevant components of the acceleration of cosmological featureless p-branes, extending previous analysis based on the field theory equations in the thin-brane limit. The component of the acceleration parallel to the velocity is at the core of the velocity-dependent one-scale model for the evolution of p-brane networks. We use this model to show that, in a decelerating expanding universe in which the p-branes are relevant cosmologically, interactions cannot lead to frustration, except for fine-tuned nonrelativistic networks with a dimensionless curvature parameter k<<1. We discuss the implications of our findings for the cosmological evolution of p-brane networks.

  18. Cosmology understanding the evolution of the universe

    CERN Document Server

    2015-01-01

    Bridging astronomy and physics, cosmology seeks to examine the nature of the universe as a whole. Scientific investigation of cosmology began in ancient times and progressed rapidly after the Scientific Revolution, which produced the discovery of gravity and the heliocentric model of Copernicus. This volume examines the historical developments in the field of cosmology, the evidence supporting the Big Bang theory, and the future implications of dark matter and an expanding universe. Readers will also be introduced to the various thinkers who helped advance study of this endlessly fascinating f

  19. No hair theorem for inhomogeneous cosmologies

    International Nuclear Information System (INIS)

    Jensen, L.G.; Stein-Schabes, J.A.

    1986-03-01

    We show that under very general conditions any inhomogeneous cosmological model with a positive cosmological constant, that can be described in a synchronous reference system will tend asymptotically in time towards the de Sitter solution. This is shown to be relevant in the context of inflationary models as it makes inflation very weakly dependent on initial conditions. 8 refs

  20. Is there evidence for additional neutrino species from cosmology?

    CERN Document Server

    Feeney, Stephen M.; Verde, Licia

    2013-01-01

    It has been suggested that recent cosmological and flavor-oscillation data favor the existence of additional neutrino species beyond the three predicted by the Standard Model of particle physics. We apply Bayesian model selection to determine whether there is indeed any evidence from current cosmological datasets for the standard cosmological model to be extended to include additional neutrino flavors. The datasets employed include cosmic microwave background temperature, polarization and lensing power spectra, and measurements of the baryon acoustic oscillation scale and the Hubble constant. We also consider other extensions to the standard neutrino model, such as massive neutrinos, and possible degeneracies with other cosmological parameters. The Bayesian evidence indicates that current cosmological data do not require any non-standard neutrino properties.