WorldWideScience

Sample records for kancrn research model

  1. Influence of the Kansas Collaborative Research Network on teacher beliefs, instructional practices and technology integration

    Science.gov (United States)

    Andersen, Gary G.

    Student-centered inquiry has been advocated for a lengthy period of time, through various waves of reform, and in 1996 was included in the vision of the National Science Education Standards. In 1997, the United States Department of Education awarded Kansas City, Kansas Public Schools a Technology Innovation Challenge Grant to support the Kansas Collaborative Research Network (KanCRN), which was an attempt to fulfill this vision by engaging teachers and students in scientific inquiry. KanCRN supported inquiry by providing teachers of various disciplines with project-based professional development, on-line curriculum and research tools, mentors, materials and equipment. This study examines the influences of KanCRN interventions on teachers' beliefs, classroom practices, technology skill-efficacies, and the integration of technology into classroom practices. Background characteristics of teachers and the influence of contemporary school-based professional development also were included in the research in order to evaluate and compare their impact on participation in KanCRN and the teacher outcome variables. Survey data collected on participation in professional development, beliefs and teaching practices were analyzed using a process that included: (a) factor analysis to assure reliability of constructs, (b) generation of theoretical models, and (c) analysis of those models using structural equation analysis. Longitudinal data concerning teacher beliefs and practices also were examined with a paired-comparison t-test. Analysis of the structural models revealed that KanCRN had significant and positive influences on teachers': (a) beliefs about student inquiry abilities, (b) beliefs about authentic and engaging work, (c) self-efficacy in support of inquiry, (d) self-reported content expertise, (e) frequency of use of authentic/engaging classwork, (f) frequency of use of the research process, (g) frequency of use of project/problem-based learning, (h) technology self

  2. Mathematical modeling in psychological researches

    Directory of Open Access Journals (Sweden)

    Aleksandra Zyolko

    2013-04-01

    Full Text Available The author considers the nature of mathematical modeling and its significance in psychological researches. The author distinguishes the types of mathematical models: deterministic, stochastic models and synergetic models. The system approach is proposed as an instrument of implementation of mathematical modelling in psychological research.

  3. Drosophila models for cancer research.

    Science.gov (United States)

    Vidal, Marcos; Cagan, Ross L

    2006-02-01

    Drosophila is a model system for cancer research. Investigation with fruit flies has facilitated a number of important recent discoveries in the field: the hippo signaling pathway, which coordinates cell proliferation and death to achieve normal tissue size; 'social' behaviors of cells, including cell competition and apoptosis-induced compensatory proliferation, that help ensure normal tissue size; and a growing understanding of how oncogenes and tumor suppressors cooperate to achieve tumor growth and metastasis in situ. In the future, Drosophila models can be extended beyond basic research in the search for human therapeutics.

  4. Mouse models for cancer research

    Institute of Scientific and Technical Information of China (English)

    Wei Zhang; Lynette Moore; Ping Ji

    2011-01-01

    Mouse models of cancer enable researchers to leamn about tumor biology in complicated and dynamic physiological systems. Since the development of gene targeting in mice, cancer biologists have been among the most frequent users of transgenic mouse models, which have dramatically increased knowledge about how cancers form and grow. The Chinese Joumnal of Cancer will publish a series of papers reporting the use of mouse models in studying genetic events in cancer cases. This editorial is an overview of the development and applications of mouse models of cancer and directs the reader to upcoming papers describing the use of these models to be published in coming issues, beginning with three articles in the current issue.

  5. Multidisciplinary research of geothermal modeling

    Science.gov (United States)

    -Ing. Ulvi Arslan, Univ., ., Dr. _., Prof.; Heiko Huber, Dipl.-Ing.

    2010-05-01

    KEYWORDS Geothermal sciences, geothermics, research, theory and application, numerical calculation, geothermal modeling, Technical University Darmstadt, Ministry of Economics and Technology (BMWi) INTRODUCTION In times of global warming renewable, green energies are getting more and more important. The development of application of geothermal energy as a part of renewable energies in Germany is a multidisciplinary process of fast growing research and improvements. Geothermal energy is the energy, which is stored below earth's surface. The word geothermal derives from the Greek words geo (earth) and thermos (heat), so geothermal is a synonym to earth heat. Geothermal energy is one of the auspicious renewable energies. In average the temperature increases 3°C every 100 m of depth, which is termed as geothermal gradient. Therefore 99 percent of our planet is hotter than 1.000°C, while 99 percent of that last percent is even hotter than 100°C. Already in a depth of about 1 kilometer temperatures of 35 - 40°C can be achieved. While other renewable energies arise less or more from the sun, geothermal energy sources its heat from the earth's interior, which is caused mostly by radioactive decay of persistent isotopes. This means a possibility of a base-loadable form of energy supply. Especially efficient is the use of deep geothermal energy of high-enthalpie reservoirs, which means a high energy potential in low depths. In Germany no high-enthalpie reservoirs are given. To use the given low-enthalpie potential and to generate geothermal power efficiently inventions and improvements need to be performed. An important part of geothermal progresses is performed by universities with multidisciplinary research of geothermal modeling. Especially in deep geothermal systems numerical calculations are essential for a correct dimensioning of the geothermal system. Therefore German universities and state aided organizations are developing numerical programs for a detailed use of

  6. Preclinical models for obesity research

    Directory of Open Access Journals (Sweden)

    Perry Barrett

    2016-11-01

    Full Text Available A multi-dimensional strategy to tackle the global obesity epidemic requires an in-depth understanding of the mechanisms that underlie this complex condition. Much of the current mechanistic knowledge has arisen from preclinical research performed mostly, but not exclusively, in laboratory mouse and rat strains. These experimental models mimic certain aspects of the human condition and its root causes, particularly the over-consumption of calories and unbalanced diets. As with human obesity, obesity in rodents is the result of complex gene–environment interactions. Here, we review the traditional monogenic models of obesity, their contemporary optogenetic and chemogenetic successors, and the use of dietary manipulations and meal-feeding regimes to recapitulate the complexity of human obesity. We critically appraise the strengths and weaknesses of these different models to explore the underlying mechanisms, including the neural circuits that drive behaviours such as appetite control. We also discuss the use of these models for testing and screening anti-obesity drugs, beneficial bio-actives, and nutritional strategies, with the goal of ultimately translating these findings for the treatment of human obesity.

  7. Preclinical models for obesity research.

    Science.gov (United States)

    Barrett, Perry; Mercer, Julian G; Morgan, Peter J

    2016-11-01

    A multi-dimensional strategy to tackle the global obesity epidemic requires an in-depth understanding of the mechanisms that underlie this complex condition. Much of the current mechanistic knowledge has arisen from preclinical research performed mostly, but not exclusively, in laboratory mouse and rat strains. These experimental models mimic certain aspects of the human condition and its root causes, particularly the over-consumption of calories and unbalanced diets. As with human obesity, obesity in rodents is the result of complex gene-environment interactions. Here, we review the traditional monogenic models of obesity, their contemporary optogenetic and chemogenetic successors, and the use of dietary manipulations and meal-feeding regimes to recapitulate the complexity of human obesity. We critically appraise the strengths and weaknesses of these different models to explore the underlying mechanisms, including the neural circuits that drive behaviours such as appetite control. We also discuss the use of these models for testing and screening anti-obesity drugs, beneficial bio-actives, and nutritional strategies, with the goal of ultimately translating these findings for the treatment of human obesity.

  8. Development Model for Research Infrastructures

    Science.gov (United States)

    Wächter, Joachim; Hammitzsch, Martin; Kerschke, Dorit; Lauterjung, Jörn

    2015-04-01

    Research infrastructures (RIs) are platforms integrating facilities, resources and services used by the research communities to conduct research and foster innovation. RIs include scientific equipment, e.g., sensor platforms, satellites or other instruments, but also scientific data, sample repositories or archives. E-infrastructures on the other hand provide the technological substratum and middleware to interlink distributed RI components with computing systems and communication networks. The resulting platforms provide the foundation for the design and implementation of RIs and play an increasing role in the advancement and exploitation of knowledge and technology. RIs are regarded as essential to achieve and maintain excellence in research and innovation crucial for the European Research Area (ERA). The implementation of RIs has to be considered as a long-term, complex development process often over a period of 10 or more years. The ongoing construction of Spatial Data Infrastructures (SDIs) provides a good example for the general complexity of infrastructure development processes especially in system-of-systems environments. A set of directives issued by the European Commission provided a framework of guidelines for the implementation processes addressing the relevant content and the encoding of data as well as the standards for service interfaces and the integration of these services into networks. Additionally, a time schedule for the overall construction process has been specified. As a result this process advances with a strong participation of member states and responsible organisations. Today, SDIs provide the operational basis for new digital business processes in both national and local authorities. Currently, the development of integrated RIs in Earth and Environmental Sciences is characterised by the following properties: • A high number of parallel activities on European and national levels with numerous institutes and organisations participating

  9. Model Management in Virtual Reality Research

    Directory of Open Access Journals (Sweden)

    Jungang Xu

    2007-12-01

    Full Text Available In this paper, a Bi-angle Model Management method (BiMM is proposed to manage models in virtual reality research. One angle is based on the model itself, which includes the model, model scheme, and texture; another angle is based on the model sort - each sort has its child sorts except leaf nodes. Based on this method, we have developed a model management application that has the following major functions: model management, model sort management, model query, model statistics, model registration into database as a whole, etc. With this method, researchers can manage model data conveniently and efficiently.

  10. Staged Models for Interdisciplinary Research

    CERN Document Server

    Lafuerza, Luis F; Edmonds, Bruce; McKane, Alan J

    2016-01-01

    Modellers of complex biological or social systems are often faced with an invidious choice: to use simple models with few mechanisms that can be fully analysed, or to construct complicated models that include all the features which are thought relevant. The former ensures rigour, the latter relevance. We discuss a method that combines these two approaches, beginning with a complex model and then modelling the complicated model with simpler models. The resulting "chain" of models ensures some rigour and relevance. We illustrate this process on a complex model of voting intentions, constructing a reduced model which agrees well with the predictions of the full model. Experiments with variations of the simpler model yield additional insights which are hidden by the complexity of the full model. This approach facilitated collaboration between social scientists and physicists -- the complex model was specified based on the social science literature, and the simpler model constrained to agree (in core aspects) with...

  11. A Developmental Model of Research Mentoring

    Science.gov (United States)

    Revelo, Renata A.; Loui, Michael C.

    2016-01-01

    We studied mentoring relationships between undergraduate and graduate students in a summer undergraduate research program, over three years. Using a grounded theory approach, we created a model of research mentoring that describes how the roles of the mentor and the student can change. Whereas previous models of research mentoring ignored student…

  12. Modeling Research Project Risks with Fuzzy Maps

    Science.gov (United States)

    Bodea, Constanta Nicoleta; Dascalu, Mariana Iuliana

    2009-01-01

    The authors propose a risks evaluation model for research projects. The model is based on fuzzy inference. The knowledge base for fuzzy process is built with a causal and cognitive map of risks. The map was especially developed for research projects, taken into account their typical lifecycle. The model was applied to an e-testing research…

  13. Structural Equation Modeling in Special Education Research.

    Science.gov (United States)

    Moore, Alan D.

    1995-01-01

    This article suggests the use of structural equation modeling in special education research, to analyze multivariate data from both nonexperimental and experimental research. It combines a structural model linking latent variables and a measurement model linking observed variables with latent variables. (Author/DB)

  14. Research on BOM based composable modeling method

    NARCIS (Netherlands)

    Zhang, M.; He, Q.; Gong, J.

    2013-01-01

    Composable modeling method has been a research hotpot in the area of Modeling and Simulation for a long time. In order to increase the reuse and interoperability of BOM based model, this paper put forward a composable modeling method based on BOM, studied on the basic theory of composable modeling m

  15. Quantitative models in marketing research

    NARCIS (Netherlands)

    Ph.H.B.F. Franses (Philip Hans); R. Paap (Richard)

    2001-01-01

    textabstractRecent advances in data collection and data storage techniques enable marketing researchers to study the individual characteristics of a large range of transactions and purchases, in particular the effects of household-specific characteristics. This book presents the most important and

  16. Quantitative models in marketing research

    NARCIS (Netherlands)

    Ph.H.B.F. Franses (Philip Hans); R. Paap (Richard)

    2001-01-01

    textabstractRecent advances in data collection and data storage techniques enable marketing researchers to study the individual characteristics of a large range of transactions and purchases, in particular the effects of household-specific characteristics. This book presents the most important and p

  17. Fossil fuels supplies modeling and research

    Energy Technology Data Exchange (ETDEWEB)

    Leiby, P.N.

    1996-06-01

    The fossil fuel supplies modeling and research effort focuses on models for US Strategic Petroleum Reserve (SPR) planning and management. Topics covered included new SPR oil valuation models, updating models for SPR risk analysis, and fill-draw planning. Another task in this program area is the development of advanced computational tools for three-dimensional seismic analysis.

  18. Maturity Models Development in IS Research

    DEFF Research Database (Denmark)

    Lasrado, Lester Allan; Vatrapu, Ravi; Andersen, Kim Normann

    2015-01-01

    Maturity models are widespread in IS research and in particular, IT practitioner communities. However, theoretically sound, methodologically rigorous and empirically validated maturity models are quite rare. This literature review paper focuses on the challenges faced during the development...... literature reveals that researchers have primarily focused on developing new maturity models pertaining to domain-specific problems and/or new enterprise technologies. We find rampant re-use of the design structure of widely adopted models such as Nolan’s Stage of Growth Model, Crosby’s Grid, and Capability...... Maturity Model (CMM). Only recently have there been some research efforts to standardize maturity model development. We also identify three dominant views of maturity models and provide guidelines for various approaches of constructing maturity models with a standard vocabulary. We finally propose using...

  19. Theories, Models and Methodology in Writing Research

    NARCIS (Netherlands)

    Rijlaarsdam, Gert; Bergh, van den Huub; Couzijn, Michel

    1996-01-01

    Theories, Models and Methodology in Writing Research describes the current state of the art in research on written text production. The chapters in the first part offer contributions to the creation of new theories and models for writing processes. The second part examines specific elements of the w

  20. Using Multilevel Modeling in Counseling Research

    Science.gov (United States)

    Lynch, Martin F.

    2012-01-01

    This conceptual and practical overview of multilevel modeling (MLM) for researchers in counseling and development provides guidelines on setting up SPSS to perform MLM and an example of how to present the findings. It also provides a discussion on how counseling and developmental researchers can use MLM to address their own research questions.…

  1. Nursing research and bibliographic citation models

    OpenAIRE

    Angordans,Jordi Piqué; Puig,Ramón Camaño; Noguera,Carmen Piqué

    2009-01-01

    This research focuses on the analysis of how nursing journals publish their papers. Basically, two models are analyzed, Vancouver, by the International Committee of Medical Journal Editors, and APA by the American Psychological Association. Their advantages and disadvantages are discussed. In view of how research papers are currently published and how research is judged, the authors propose that nursing journals adopt their own model, irrespective of how medical professionals publish.

  2. Introduction to Bayesian modelling in dental research.

    Science.gov (United States)

    Gilthorpe, M S; Maddick, I H; Petrie, A

    2000-12-01

    To explain the concepts and application of Bayesian modelling and how it can be applied to the analysis of dental research data. Methodological in nature, this article introduces Bayesian modelling through hypothetical dental examples. The synthesis of RCT results with previous evidence, including expert opinion, is used to illustrate full Bayesian modelling. Meta-analysis, in the form of empirical Bayesian modelling, is introduced. An example of full Bayesian modelling is described for the synthesis of evidence from several studies that investigate the success of root canal treatment. Hierarchical (Bayesian) modelling is demonstrated for a survey of childhood caries, where surface data is nested within subjects. Bayesian methods enhance interpretation of research evidence through the synthesis of information from multiple sources. Bayesian modelling is now readily accessible to clinical researchers and is able to augment the application of clinical decision making in the development of guidelines and clinical practice.

  3. Research Output, Socialization, and the Biglan Model.

    Science.gov (United States)

    Creswell, John W.; Bean, John P.

    1981-01-01

    A test of the Biglan model of faculty subcultures using measures of research output and tests of the model controlling for the effects of faculty socialization are described. The Biglan model is found to be valid, and the distinctiveness of the Biglan groups appears to increase with the socialization of faculty into subject areas. (Author/MLW)

  4. Research Output, Socialization, and the Biglan Model.

    Science.gov (United States)

    Creswell, John W.; Bean, John P.

    1981-01-01

    A test of the Biglan model of faculty subcultures using measures of research output and tests of the model controlling for the effects of faculty socialization are described. The Biglan model is found to be valid, and the distinctiveness of the Biglan groups appears to increase with the socialization of faculty into subject areas. (Author/MLW)

  5. Maturity Models Development in IS Research

    DEFF Research Database (Denmark)

    Lasrado, Lester Allan; Vatrapu, Ravi; Andersen, Kim Normann

    2015-01-01

    literature reveals that researchers have primarily focused on developing new maturity models pertaining to domain-specific problems and/or new enterprise technologies. We find rampant re-use of the design structure of widely adopted models such as Nolan’s Stage of Growth Model, Crosby’s Grid, and Capability...... of maturity models. Specifically, it explores maturity models literature in IS and standard guidelines, if any to develop maturity models, challenges identified and solutions proposed. Our systematic literature review of IS publications revealed over hundred and fifty articles on maturity models. Extant...

  6. TMDL MODEL EVALUATION AND RESEARCH NEEDS

    Science.gov (United States)

    This review examines the modeling research needs to support environmental decision-making for the 303(d) requirements for development of total maximum daily loads (TMDLs) and related programs such as 319 Nonpoint Source Program activities, watershed management, stormwater permits...

  7. Marketing research model of competitive environment

    Directory of Open Access Journals (Sweden)

    Krasilya Dmitriy

    2015-11-01

    Full Text Available To support its competitive advantages in current market conditions, each company needs to choose better ways of guaranteeing its favorable competitive position. In this regard, considerable interest lies in the structuring and algorithmization of marketing research processes that provide the information background of such choice. The article is devoted to modeling the process of marketing research of competitive environment.

  8. Structural Equation Modeling in Rehabilitation Counseling Research

    Science.gov (United States)

    Chan, Fong; Lee, Gloria K.; Lee, Eun-Jeong; Kubota, Coleen; Allen, Chase A.

    2007-01-01

    Structural equation modeling (SEM) has become increasingly popular in counseling, psychology, and rehabilitation research. The purpose of this article is to provide an overview of the basic concepts and applications of SEM in rehabilitation counseling research using the AMOS statistical software program.

  9. Interior Design Research: A Human Ecosystem Model.

    Science.gov (United States)

    Guerin, Denise A.

    1992-01-01

    The interior ecosystems model illustrates effects on the human organism of the interaction of the natural, behavioral, and built environment. Examples of interior lighting and household energy consumption show the model's flexibility for organizing study variables in interior design research. (SK)

  10. Interior Design Research: A Human Ecosystem Model.

    Science.gov (United States)

    Guerin, Denise A.

    1992-01-01

    The interior ecosystems model illustrates effects on the human organism of the interaction of the natural, behavioral, and built environment. Examples of interior lighting and household energy consumption show the model's flexibility for organizing study variables in interior design research. (SK)

  11. Model observers in medical imaging research.

    Science.gov (United States)

    He, Xin; Park, Subok

    2013-10-04

    Model observers play an important role in the optimization and assessment of imaging devices. In this review paper, we first discuss the basic concepts of model observers, which include the mathematical foundations and psychophysical considerations in designing both optimal observers for optimizing imaging systems and anthropomorphic observers for modeling human observers. Second, we survey a few state-of-the-art computational techniques for estimating model observers and the principles of implementing these techniques. Finally, we review a few applications of model observers in medical imaging research.

  12. Logical fallacies in animal model research.

    Science.gov (United States)

    Sjoberg, Espen A

    2017-02-15

    Animal models of human behavioural deficits involve conducting experiments on animals with the hope of gaining new knowledge that can be applied to humans. This paper aims to address risks, biases, and fallacies associated with drawing conclusions when conducting experiments on animals, with focus on animal models of mental illness. Researchers using animal models are susceptible to a fallacy known as false analogy, where inferences based on assumptions of similarities between animals and humans can potentially lead to an incorrect conclusion. There is also a risk of false positive results when evaluating the validity of a putative animal model, particularly if the experiment is not conducted double-blind. It is further argued that animal model experiments are reconstructions of human experiments, and not replications per se, because the animals cannot follow instructions. This leads to an experimental setup that is altered to accommodate the animals, and typically involves a smaller sample size than a human experiment. Researchers on animal models of human behaviour should increase focus on mechanistic validity in order to ensure that the underlying causal mechanisms driving the behaviour are the same, as relying on face validity makes the model susceptible to logical fallacies and a higher risk of Type 1 errors. We discuss measures to reduce bias and risk of making logical fallacies in animal research, and provide a guideline that researchers can follow to increase the rigour of their experiments.

  13. Applied research in uncertainty modeling and analysis

    CERN Document Server

    Ayyub, Bilal

    2005-01-01

    Uncertainty has been a concern to engineers, managers, and scientists for many years. For a long time uncertainty has been considered synonymous with random, stochastic, statistic, or probabilistic. Since the early sixties views on uncertainty have become more heterogeneous. In the past forty years numerous tools that model uncertainty, above and beyond statistics, have been proposed by several engineers and scientists. The tool/method to model uncertainty in a specific context should really be chosen by considering the features of the phenomenon under consideration, not independent of what is known about the system and what causes uncertainty. In this fascinating overview of the field, the authors provide broad coverage of uncertainty analysis/modeling and its application. Applied Research in Uncertainty Modeling and Analysis presents the perspectives of various researchers and practitioners on uncertainty analysis and modeling outside their own fields and domain expertise. Rather than focusing explicitly on...

  14. Animal models in motion sickness research

    Science.gov (United States)

    Daunton, Nancy G.

    1990-01-01

    Practical information on candidate animal models for motion sickness research and on methods used to elicit and detect motion sickness in these models is provided. Four good potential models for use in motion sickness experiments include the dog, cat, squirrel monkey, and rat. It is concluded that the appropriate use of the animal models, combined with exploitation of state-of-the-art biomedical techniques, should generate a great step forward in the understanding of motion sickness mechanisms and in the development of efficient and effective approaches to its prevention and treatment in humans.

  15. Final Project Report Load Modeling Transmission Research

    Energy Technology Data Exchange (ETDEWEB)

    Lesieutre, Bernard [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Bravo, Richard [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Yinger, Robert [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Chassin, Dave [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Huang, Henry [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Lu, Ning [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Hiskens, Ian [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Venkataramanan, Giri [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2012-03-31

    The research presented in this report primarily focuses on improving power system load models to better represent their impact on system behavior. The previous standard load model fails to capture the delayed voltage recovery events that are observed in the Southwest and elsewhere. These events are attributed to stalled air conditioner units after a fault. To gain a better understanding of their role in these events and to guide modeling efforts, typical air conditioner units were testing in laboratories. Using data obtained from these extensive tests, new load models were developed to match air conditioner behavior. An air conditioner model is incorporated in the new WECC composite load model. These models are used in dynamic studies of the West and can impact power transfer limits for California. Unit-level and systemlevel solutions are proposed as potential solutions to the delayed voltage recovery problem.

  16. Mouse Model Resources for Vision Research

    Directory of Open Access Journals (Sweden)

    Jungyeon Won

    2011-01-01

    Full Text Available The need for mouse models, with their well-developed genetics and similarity to human physiology and anatomy, is clear and their central role in furthering our understanding of human disease is readily apparent in the literature. Mice carrying mutations that alter developmental pathways or cellular function provide model systems for analyzing defects in comparable human disorders and for testing therapeutic strategies. Mutant mice also provide reproducible, experimental systems for elucidating pathways of normal development and function. Two programs, the Eye Mutant Resource and the Translational Vision Research Models, focused on providing such models to the vision research community are described herein. Over 100 mutant lines from the Eye Mutant Resource and 60 mutant lines from the Translational Vision Research Models have been developed. The ocular diseases of the mutant lines include a wide range of phenotypes, including cataracts, retinal dysplasia and degeneration, and abnormal blood vessel formation. The mutations in disease genes have been mapped and in some cases identified by direct sequencing. Here, we report 3 novel alleles of Crxtvrm65, Rp1tvrm64, and Rpe65tvrm148 as successful examples of the TVRM program, that closely resemble previously reported knockout models.

  17. Pender's health promotion model in medical research.

    Science.gov (United States)

    Heydari, Abbas; Khorashadizadeh, Fatemeh

    2014-09-01

    This review shows how researchers use pander's health promotion model. We included all articles in which Pender's health promotion has been used for theoretical framework. Eligible articles were selected according to review of abstracts. Search was conducted using the electronic database from 1990 to 2012. Based on our search, 74 articles with various methodologies were relevant for review. Their aims of these studies were to predict effective factors/barriers in health promotion behaviours, to detect effects of intervention programme for improving health promotion behaviours, test the model, identify quality of life and health promotion behaviour, predict stage of change in related factors that affect health promotion behaviour, prevent the events that interfere with health promotion behaviour, develop another model similar to this model, compare this model with another model, determine the relationship of variables associated to health promotion behaviours.

  18. Intelligent CAD Methodology Research of Adaptive Modeling

    Institute of Scientific and Technical Information of China (English)

    ZHANG Weibo; LI Jun; YAN Jianrong

    2006-01-01

    The key to carry out ICAD technology is to establish the knowledge-based and wide rang of domains-covered product model. This paper put out a knowledge-based methodology of adaptive modeling. It is under the Ontology mind, using the Object-Oriented technology and being a knowledge-based model framework. It involves the diverse domains in product design and realizes the multi-domain modeling, embedding the relative information including standards, regulars and expert experience. To test the feasibility of the methodology, the research bonds of the automotive diaphragm spring clutch design and an adaptive clutch design model is established, using the knowledge-based modeling language-AML.

  19. Energy Systems Modelling Research and Analysis

    DEFF Research Database (Denmark)

    Møller Andersen, Frits; Alberg Østergaard, Poul

    2015-01-01

    This editorial introduces the seventh volume of the International Journal of Sustainable Energy Planning and Management. The volume presents part of the outcome of the project Energy Systems Modelling Research and Analysis (ENSYMORA) funded by the Danish Innovation Fund. The project carried out...

  20. Virtual Research Environments for Natural Hazard Modelling

    Science.gov (United States)

    Napier, Hazel; Aldridge, Tim

    2017-04-01

    The Natural Hazards Partnership (NHP) is a group of 17 collaborating public sector organisations providing a mechanism for co-ordinated advice to government and agencies responsible for civil contingency and emergency response during natural hazard events. The NHP has set up a Hazard Impact Model (HIM) group tasked with modelling the impact of a range of UK hazards with the aim of delivery of consistent hazard and impact information. The HIM group consists of 7 partners initially concentrating on modelling the socio-economic impact of 3 key hazards - surface water flooding, land instability and high winds. HIM group partners share scientific expertise and data within their specific areas of interest including hydrological modelling, meteorology, engineering geology, GIS, data delivery, and modelling of socio-economic impacts. Activity within the NHP relies on effective collaboration between partners distributed across the UK. The NHP are acting as a use case study for a new Virtual Research Environment (VRE) being developed by the EVER-EST project (European Virtual Environment for Research - Earth Science Themes: a solution). The VRE is allowing the NHP to explore novel ways of cooperation including improved capabilities for e-collaboration, e-research, automation of processes and e-learning. Collaboration tools are complemented by the adoption of Research Objects, semantically rich aggregations of resources enabling the creation of uniquely identified digital artefacts resulting in reusable science and research. Application of the Research Object concept to HIM development facilitates collaboration, by encapsulating scientific knowledge in a shareable format that can be easily shared and used by partners working on the same model but within their areas of expertise. This paper describes the application of the VRE to the NHP use case study. It outlines the challenges associated with distributed partnership working and how they are being addressed in the VRE. A case

  1. Business model in research-development activity

    Directory of Open Access Journals (Sweden)

    Koszałka Jerzy

    2016-09-01

    Full Text Available The partners and allies of business practice in the processes of modernization of the economy are scientific-research institutions, such as scientific institutes, research-development units and universities. A market on which companies can look for the solutions they need and scientific-research institutions can look for inspiration, partners and capital is being formed. The market provides conditions for operation, development and implementation of developed solutions. Taking into consideration the complexity of market, technical, legal, financial, or intellectual property protection issues, research-development units are more and more frequently unable to function efficiently without a clear and unequivocal definition of goals, methods and conditions of activity. Their market offer has to take into consideration not just scientific-research, or methodological aspects. Taking into consideration continuously growing demands of the clients and pressure of the competition, scientific-research institutions have to pay attention also to market, information, personnel, or financial aspects typical of strictly commercial ventures. What may support a comprehensive preparation and implementation of scientific-research activities under market conditions are tools successfully used in trade and economy, such as business models. These issues are the basis of deliberations contained in this work.

  2. Mouse models in male fertility research

    Institute of Scientific and Technical Information of China (English)

    Duangporn Jamsai; Moira K O'Bryan

    2011-01-01

    Limited knowledge of the genetic causes of male infertility has resulted in few treatment and targeted therapeutic options.Although the ideal approach to identify infertility causing mutations is to conduct studies in the human population,this approach has progressed slowly due to the limitations described herein.Given the complexity of male fertility,the entire process cannot be modeled in vitro.As such,animal models,in particular mouse models,provide a valuable alternative for gene identification and experimentation.Since the introduction of molecular biology and recent advances in animal model production,there has been a substantial acceleration in the identification and characterization of genes associated with many diseases,including infertility.Three major types of mouse models are commonly used in biomedical research,including knockout/knockin/gene-trapped,transgenic and chemical-induced point mutant mice.Using these mouse models,over 400 genes essential for male fertility have been revealed.It has,however,been estimated that thousands of genes are involved in the regulation of the complex process of male fertility,as many such genes remain to be characterized.The current review is by no means a comprehensive list of these mouse models,rather it contains examples of how mouse models have advanced our knowledge of post-natal germ cell development and male fertility regulation.

  3. Rodent Models for Metabolic Syndrome Research

    Directory of Open Access Journals (Sweden)

    Sunil K. Panchal

    2011-01-01

    Full Text Available Rodents are widely used to mimic human diseases to improve understanding of the causes and progression of disease symptoms and to test potential therapeutic interventions. Chronic diseases such as obesity, diabetes and hypertension, together known as the metabolic syndrome, are causing increasing morbidity and mortality. To control these diseases, research in rodent models that closely mimic the changes in humans is essential. This review will examine the adequacy of the many rodent models of metabolic syndrome to mimic the causes and progression of the disease in humans. The primary criterion will be whether a rodent model initiates all of the signs, especially obesity, diabetes, hypertension and dysfunction of the heart, blood vessels, liver and kidney, primarily by diet since these are the diet-induced signs in humans with metabolic syndrome. We conclude that the model that comes closest to fulfilling this criterion is the high carbohydrate, high fat-fed male rodent.

  4. [A transdisciplinary model for public health research].

    Science.gov (United States)

    Betancourt, José Aureliano

    2013-11-01

    Human resources education for health workers has been predominantly discipline-oriented and fragmented, influencing research design and, in turn, scientific output. Several authors argue that university education should transition from disciplinarity to transdisciplinarity. To gather the theoretical underpinnings for this subject of international interest, a literature search was conducted in the PubMed, EBSCO, and SciELO databases in 2012, using the terms "transdisciplinary and translational research" in Spanish and English. The majority of authors believe that identifying problems from different perspectives by specialists and community members and leaders will be conducive to more effective intersectoral interventions. They suggest undertaking organizational change to reshape reshaping work styles and self-organizational forms of scientific activity. Finally, a transdisciplinary model for public health research has been proposed that is based on traditional project design tools, but with variations borrowed from a complex systems approach.

  5. Energy Systems Modelling Research and Analysis

    DEFF Research Database (Denmark)

    Møller Andersen, Frits; Alberg Østergaard, Poul

    2015-01-01

    This editorial introduces the seventh volume of the International Journal of Sustainable Energy Planning and Management. The volume presents part of the outcome of the project Energy Systems Modelling Research and Analysis (ENSYMORA) funded by the Danish Innovation Fund. The project carried out...... by 11 university and industry partners has improved the basis for decision-making within energy planning and energy scenario making by providing new and improved tools and methods for energy systems analyses....

  6. SARS epidemical forecast research in mathematical model

    Institute of Scientific and Technical Information of China (English)

    DING Guanghong; LIU Chang; GONG Jianqiu; WANG Ling; CHENG Ke; ZHANG Di

    2004-01-01

    The SIJR model, simplified from the SEIJR model, is adopted to analyze the important parameters of the model of SARS epidemic such as the transmission rate, basic reproductive number. And some important parameters are obtained such as the transmission rate by applying this model to analyzing the situation in Hong Kong, Singapore and Canada at the outbreak of SARS. Then forecast of the transmission of SARS is drawn out here by the adjustment of parameters (such as quarantined rate) in the model. It is obvious that inflexion lies on the crunode of the graph, which indicates the big difference in transmission characteristics between the epidemic under control and not under control. This model can also be used in the comparison of the control effectiveness among different regions. The results from this model match well with the actual data in Hong Kong, Singapore and Canada and as a by-product, the index of the effectiveness of control in the later period can be acquired. It offers some quantitative indexes, which may help the further research in epidemic diseases.

  7. Importance of animal models in schizophrenia research.

    Science.gov (United States)

    van den Buuse, M; Garner, B; Gogos, A; Kusljic, S

    2005-07-01

    This review aims to summarize the importance of animal models for research on psychiatric illnesses, particularly schizophrenia. Several aspects of animal models are addressed, including animal experimentation ethics and theoretical considerations of different aspects of validity of animal models. A more specific discussion is included on two of the most widely used behavioural models, psychotropic drug-induced locomotor hyperactivity and prepulse inhibition, followed by comments on the difficulty of modelling negative symptoms of schizophrenia. Furthermore, we emphasize the impact of new developments in molecular biology and the generation of genetically modified mice, which have generated the concept of behavioural phenotyping. Complex psychiatric illnesses, such as schizophrenia, cannot be exactly reproduced in species such as rats and mice. Nevertheless, by providing new information on the role of neurotransmitter systems and genes in behavioural function, animal 'models' can be an important tool in unravelling mechanisms involved in the symptoms and development of such illnesses, alongside approaches such as post-mortem studies, cognitive and psychophysiological studies, imaging and epidemiology.

  8. Terrain Simplification Research in Augmented Scene Modeling

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    environment. As one of the most important tasks in augmented scene modeling, terrain simplification research has gained more and more attention. In this paper, we mainly focus on point selection problem in terrain simplification using triangulated irregular network. Based on the analysis and comparison of traditional importance measures for each input point, we put forward a new importance measure based on local entropy. The results demonstrate that the local entropy criterion has a better performance than any traditional methods. In addition, it can effectively conquer the "short-sight" problem associated with the traditional methods.

  9. Animal Models Utilized in HTLV-1 Research.

    Science.gov (United States)

    Panfil, Amanda R; Al-Saleem, Jacob J; Green, Patrick L

    2013-01-01

    Since the isolation and discovery of human T-cell leukemia virus type 1 (HTLV-1) over 30 years ago, researchers have utilized animal models to study HTLV-1 transmission, viral persistence, virus-elicited immune responses, and HTLV-1-associated disease development (ATL, HAM/TSP). Non-human primates, rabbits, rats, and mice have all been used to help understand HTLV-1 biology and disease progression. Non-human primates offer a model system that is phylogenetically similar to humans for examining viral persistence. Viral transmission, persistence, and immune responses have been widely studied using New Zealand White rabbits. The advent of molecular clones of HTLV-1 has offered the opportunity to assess the importance of various viral genes in rabbits, non-human primates, and mice. Additionally, over-expression of viral genes using transgenic mice has helped uncover the importance of Tax and Hbz in the induction of lymphoma and other lymphocyte-mediated diseases. HTLV-1 inoculation of certain strains of rats results in histopathological features and clinical symptoms similar to that of humans with HAM/TSP. Transplantation of certain types of ATL cell lines in immunocompromised mice results in lymphoma. Recently, "humanized" mice have been used to model ATL development for the first time. Not all HTLV-1 animal models develop disease and those that do vary in consistency depending on the type of monkey, strain of rat, or even type of ATL cell line used. However, the progress made using animal models cannot be understated as it has led to insights into the mechanisms regulating viral replication, viral persistence, disease development, and, most importantly, model systems to test disease treatments.

  10. Monte Carlo modelling of TRIGA research reactor

    Science.gov (United States)

    El Bakkari, B.; Nacir, B.; El Bardouni, T.; El Younoussi, C.; Merroun, O.; Htet, A.; Boulaich, Y.; Zoubair, M.; Boukhal, H.; Chakir, M.

    2010-10-01

    The Moroccan 2 MW TRIGA MARK II research reactor at Centre des Etudes Nucléaires de la Maâmora (CENM) achieved initial criticality on May 2, 2007. The reactor is designed to effectively implement the various fields of basic nuclear research, manpower training, and production of radioisotopes for their use in agriculture, industry, and medicine. This study deals with the neutronic analysis of the 2-MW TRIGA MARK II research reactor at CENM and validation of the results by comparisons with the experimental, operational, and available final safety analysis report (FSAR) values. The study was prepared in collaboration between the Laboratory of Radiation and Nuclear Systems (ERSN-LMR) from Faculty of Sciences of Tetuan (Morocco) and CENM. The 3-D continuous energy Monte Carlo code MCNP (version 5) was used to develop a versatile and accurate full model of the TRIGA core. The model represents in detailed all components of the core with literally no physical approximation. Continuous energy cross-section data from the more recent nuclear data evaluations (ENDF/B-VI.8, ENDF/B-VII.0, JEFF-3.1, and JENDL-3.3) as well as S( α, β) thermal neutron scattering functions distributed with the MCNP code were used. The cross-section libraries were generated by using the NJOY99 system updated to its more recent patch file "up259". The consistency and accuracy of both the Monte Carlo simulation and neutron transport physics were established by benchmarking the TRIGA experiments. Core excess reactivity, total and integral control rods worth as well as power peaking factors were used in the validation process. Results of calculations are analysed and discussed.

  11. Models and design principles for teacher research

    NARCIS (Netherlands)

    Admiraal, Wilfried; Smit, Ben; Zwart, Rosanne|info:eu-repo/dai/nl/298981823

    2014-01-01

    Teacher research is a way to bridge the gap between theory and teaching practice. Various types of teacher research can be distinguished, including most commonly: action research, selfstudy, lesson study, design-based research, and scholarship of teaching and learning. All types of teacher research

  12. Models and design principles for teacher research

    NARCIS (Netherlands)

    Admiraal, Wilfried; Smit, Ben; Zwart, Rosanne

    2014-01-01

    Teacher research is a way to bridge the gap between theory and teaching practice. Various types of teacher research can be distinguished, including most commonly: action research, selfstudy, lesson study, design-based research, and scholarship of teaching and learning. All types of teacher research

  13. Prognosis Research Strategy (PROGRESS 3: prognostic model research.

    Directory of Open Access Journals (Sweden)

    Ewout W Steyerberg

    Full Text Available Prognostic models are abundant in the medical literature yet their use in practice seems limited. In this article, the third in the PROGRESS series, the authors review how such models are developed and validated, and then address how prognostic models are assessed for their impact on practice and patient outcomes, illustrating these ideas with examples.

  14. Modeling and Analyzing Academic Researcher Behavior

    Directory of Open Access Journals (Sweden)

    Phuc Huu Nguyen

    2016-12-01

    Full Text Available Abstract. This paper suggests a theoretical framework for analyzing the mechanism of the behavior of academic researchers whose interests are tangled and vary widely in academic factors (the intrinsic satisfaction in conducting research, the improvement in individual research ability, etc. or non-academic factors (career rewards, financial rewards, etc.. Furthermore, each researcher also has his/her different academic stances in their preferences about academic freedom and academic entrepreneurship. Understanding the behavior of academic researchers will contribute to nurture young researchers, to improve the standard of research and education as well as to boost collaboration in academia-industry. In particular, as open innovation is increasingly in need of the involvement of university researchers, to establish a successful approach to entice researchers into enterprises’ research, companies must comprehend the behavior of university researchers who have multiple complex motivations. The paper explores academic researchers' behaviors through optimizing their utility functions, i.e. the satisfaction obtained by their research outputs. This paper characterizes these outputs as the results of researchers' 3C: Competence (the ability to implement the research, Commitment (the effort to do the research, and Contribution (finding meaning in the research. Most of the previous research utilized the empirical methods to study researcher's motivation. Without adopting economic theory into the analysis, the past literature could not offer a deeper understanding of researcher's behavior. Our contribution is important both conceptually and practically because it provides the first theoretical framework to study the mechanism of researcher's behavior. Keywords: Academia-Industry, researcher behavior, ulrich model’s 3C.

  15. Animal Models and Bone Histomorphometry: Translational Research for the Human Research Program

    Science.gov (United States)

    Sibonga, Jean D.

    2010-01-01

    This slide presentation reviews the use of animal models to research and inform bone morphology, in particular relating to human research in bone loss as a result of low gravity environments. Reasons for use of animal models as tools for human research programs include: time-efficient, cost-effective, invasive measures, and predictability as some model are predictive for drug effects.

  16. Domestic animals as models for biomedical research.

    Science.gov (United States)

    Andersson, Leif

    2016-01-01

    Domestic animals are unique models for biomedical research due to their long history (thousands of years) of strong phenotypic selection. This process has enriched for novel mutations that have contributed to phenotype evolution in domestic animals. The characterization of such mutations provides insights in gene function and biological mechanisms. This review summarizes genetic dissection of about 50 genetic variants affecting pigmentation, behaviour, metabolic regulation, and the pattern of locomotion. The variants are controlled by mutations in about 30 different genes, and for 10 of these our group was the first to report an association between the gene and a phenotype. Almost half of the reported mutations occur in non-coding sequences, suggesting that this is the most common type of polymorphism underlying phenotypic variation since this is a biased list where the proportion of coding mutations are inflated as they are easier to find. The review documents that structural changes (duplications, deletions, and inversions) have contributed significantly to the evolution of phenotypic diversity in domestic animals. Finally, we describe five examples of evolution of alleles, which means that alleles have evolved by the accumulation of several consecutive mutations affecting the function of the same gene.

  17. Mental Models of Research: Generating Authentic Questions

    Science.gov (United States)

    Donham, Jean; Heinrich, Jill A.; Bostwick, Kerry A.

    2010-01-01

    In this paper, we question how we might disrupt positivist research paradigms that preclude students from engaging and experiencing ownership in the research process. We question what we, as professors, could do to facilitate the transition from traditional research reporting to a disposition of inquiry that allows for ambiguity and discovery in…

  18. Research on an Integrated Enterprise Workflow Model

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    An integrated enterprise workflow model called PPROCE is presented firstly. Then, an enterprise's ontology established by TOVE and Process Specification Language (PSL) is studied. Combined with TOVE's partition idea, PSL is extended and new PSL Extensions is created to define the ontology of process, organization, resource and product in the PPROCE model. As a result, PPROCE model can be defined by a set of corresponding formal language. It facilitates the future work not only in the model verification, model optimization and model simulation, but also in the model translation.

  19. Advanced Applications of Structural Equation Modeling in Counseling Psychology Research

    Science.gov (United States)

    Martens, Matthew P.; Haase, Richard F.

    2006-01-01

    Structural equation modeling (SEM) is a data-analytic technique that allows researchers to test complex theoretical models. Most published applications of SEM involve analyses of cross-sectional recursive (i.e., unidirectional) models, but it is possible for researchers to test more complex designs that involve variables observed at multiple…

  20. Model Observers in Medical Imaging Research

    OpenAIRE

    He, Xin; Park, Subok

    2013-01-01

    Model observers play an important role in the optimization and assessment of imaging devices. In this review paper, we first discuss the basic concepts of model observers, which include the mathematical foundations and psychophysical considerations in designing both optimal observers for optimizing imaging systems and anthropomorphic observers for modeling human observers. Second, we survey a few state-of-the-art computational techniques for estimating model observers and the principles of im...

  1. Research on Virtual Agent Perception Model

    Institute of Scientific and Technical Information of China (English)

    FENG Xiu-fang; GAO Bao-lu

    2006-01-01

    An intelligent virtual environment is described for training users in the operation of complex engineering systems. After analyzing the original model of virtual environment, a virtual agent perception model was put forward. The information layer was inserted into original virtual environment. The model classifies all kinds of information and offers a way for knowledge description of virtual environment, and contributes to set up feeling model for the Virtual Agent within virtual environment.

  2. Research on Event Handling Models of Java

    Institute of Scientific and Technical Information of China (English)

    WU Yue; WU Jing; ZHOU Ming-tian

    2004-01-01

    A new event-handling paradigm and its application model are proposed. The working mechanism and principle of event listener model is given in detail. Finally, the launching event mechanisms,the choosing event handling models and the dispatching mechanism are illustrated.

  3. FDA Scientists Develop Mouse Model for Zika Research

    Science.gov (United States)

    ... news/fullstory_162111.html FDA Scientists Develop Mouse Model for Zika Research Researchers hope strain of mice will help speed development of vaccines, treatments To use the sharing features on this page, please enable JavaScript. (*this news ...

  4. Research on nonlinear stochastic dynamical price model

    Energy Technology Data Exchange (ETDEWEB)

    Li Jiaorui [Department of Applied Mathematics, Northwestern Polytechnical University, Xi' an 710072 (China); School of Statistics, Xi' an University of Finance and Economics, Xi' an 710061 (China)], E-mail: jiaoruili@mail.nwpu.edu.cn; Xu Wei; Xie Wenxian; Ren Zhengzheng [Department of Applied Mathematics, Northwestern Polytechnical University, Xi' an 710072 (China)

    2008-09-15

    In consideration of many uncertain factors existing in economic system, nonlinear stochastic dynamical price model which is subjected to Gaussian white noise excitation is proposed based on deterministic model. One-dimensional averaged Ito stochastic differential equation for the model is derived by using the stochastic averaging method, and applied to investigate the stability of the trivial solution and the first-passage failure of the stochastic price model. The stochastic price model and the methods presented in this paper are verified by numerical studies.

  5. Forging Alliances in Interdisciplinary Rehabilitation Research (FAIRR): A Logic Model.

    Science.gov (United States)

    Gill, Simone V; Khetani, Mary A; Yinusa-Nyahkoon, Leanne; McManus, Beth; Gardiner, Paula M; Tickle-Degnen, Linda

    2017-07-01

    In a patient-centered care era, rehabilitation can benefit from researcher-clinician collaboration to effectively and efficiently produce the interdisciplinary science that is needed to improve patient-centered outcomes. The authors propose the use of the Forging Alliances in Interdisciplinary Rehabilitation Research (FAIRR) logic model to provide guidance to rehabilitation scientists and clinicians who are committed to growing their involvement in interdisciplinary rehabilitation research. We describe the importance and key characteristics of the FAIRR model for conducting interdisciplinary rehabilitation research.

  6. Research on artistic gymnastics training guidance model

    Science.gov (United States)

    Luo, Lin; Sun, Xianzhong

    2017-04-01

    Rhythmic gymnastics training guidance model, taking into consideration the features of artistic gymnastics training, is put forward to help gymnasts identify their deficiencies and unskilled technical movements and improve their training effects. The model is built on the foundation of both physical quality indicator model and artistic gymnastics training indicator model. Physical quality indicator model composed of bodily factor, flexibility-strength factor and speed-dexterity factor delivers an objective evaluation with reference to basic sport testing data. Training indicator model, based on physical fitness indicator, helps analyze the technical movements, through which the impact from each bodily factor on technical movements is revealed. AG training guidance model, in further combination with actual training data and in comparison with the data shown in the training indicator model, helps identify the problems in trainings, and thus improve the training effect. These three models when in combined use and in comparison with historical model data can check and verify the improvement in training effect over a certain period of time.

  7. EFFICIENT PREDICTIVE MODELLING FOR ARCHAEOLOGICAL RESEARCH

    OpenAIRE

    Balla, A.; Pavlogeorgatos, G.; Tsiafakis, D.; Pavlidis, G.

    2014-01-01

    The study presents a general methodology for designing, developing and implementing predictive modelling for identifying areas of archaeological interest. The methodology is based on documented archaeological data and geographical factors, geospatial analysis and predictive modelling, and has been applied to the identification of possible Macedonian tombs’ locations in Northern Greece. The model was tested extensively and the results were validated using a commonly used predictive gain,...

  8. Material Model Research on Rubber Vibration Isolators

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    A viscohyperelastic constitutive model is proposed to describe the mechanical behaviour of vibration isolation rubber under broad-band vibration. This constitutive model comprises two parts: a component with three parameters to characterize the hyperelastic static properties of rubber materials,and the other component incorporating two relaxation time parameters, corresponding to high and low strain rates, respectively, to describe the dynamic response under vibration and impact loadings. Based on this proposed constitutive model, a series of experiments were performed on two types of rubber materials over a wide strain rate range. The results predicted from this model are in good agreement with the experimental data.

  9. Undergraduate Research: Mathematical Modeling of Mortgages

    Science.gov (United States)

    Choi, Youngna; Spero, Steven

    2010-01-01

    In this article, we study financing in the real estate market and show how various types of mortgages can be modeled and analyzed. With only an introductory level of interest theory, finance, and calculus, we model and analyze three types of popular mortgages with real life examples that explain the background and inevitable outcome of the current…

  10. Basic Research on Adaptive Model Algorithmic Control

    Science.gov (United States)

    1985-12-01

    Control Conference. Richalet, J., A. Rault, J.L. Testud and J. Papon (1978). Model predictive heuristic control: applications to industrial...pp.977-982. Richalet, J., A. Rault, J. L. Testud and J. Papon (1978). Model predictive heuristic control: applications to industrial processes

  11. Nonlinear and Non Normal Regression Models in Physiological Research

    OpenAIRE

    1984-01-01

    Applications of nonlinear and non normal regression models are in increasing order for appropriate interpretation of complex phenomenon of biomedical sciences. This paper reviews critically some applications of these models physiological research.

  12. Modeling management of research and education networks

    NARCIS (Netherlands)

    Galagan, D.V.

    2004-01-01

    Computer networks and their services have become an essential part of research and education. Nowadays every modern R&E institution must have a computer network and provide network services to its students and staff. In addition to its internal computer network, every R&E institution must have a con

  13. Translating Research into a Seamless Transition Model

    Science.gov (United States)

    Luecking, Debra Martin; Luecking, Richard G.

    2015-01-01

    Recently, consensus among researchers and professionals has emerged about factors that contribute to postschool success of youth with disabilities. Prominent among these factors are targeted academic preparation, family involvement, youth empowerment, and service collaboration and linkages. Work experience and paid employment have been identified…

  14. Advances in Bayesian Modeling in Educational Research

    Science.gov (United States)

    Levy, Roy

    2016-01-01

    In this article, I provide a conceptually oriented overview of Bayesian approaches to statistical inference and contrast them with frequentist approaches that currently dominate conventional practice in educational research. The features and advantages of Bayesian approaches are illustrated with examples spanning several statistical modeling…

  15. Mesoscale Modeling, Forecasting and Remote Sensing Research.

    Science.gov (United States)

    remote sensing , cyclonic scale diagnostic studies and mesoscale numerical modeling and forecasting are summarized. Mechanisms involved in the release of potential instability are discussed and simulated quantitatively, giving particular attention to the convective formulation. The basic mesoscale model is documented including the equations, boundary condition, finite differences and initialization through an idealized frontal zone. Results of tests including a three dimensional test with real data, tests of convective/mesoscale interaction and tests with a detailed

  16. Research management team (RMT): a model for research support services at Duke University.

    Science.gov (United States)

    Snyder, Denise C; Epps, Shelly; Beresford, Henry F; Ennis, Cory; Levens, Justin S; Woody, Stephen K; Tcheng, James E; Stacy, Mark A; Nahm, Meredith

    2012-12-01

    Collecting and managing data for clinical and translational research presents significant challenges for clinical and translational researchers, many of whom lack needed access to data management expertise, methods, and tools. At many institutions, funding constraints result in differential levels of research informatics support among investigators. In addition, the lack of widely shared models and ontologies for clinical research informatics and health information technology hampers the accurate assessment of investigators' needs and complicates the efficient allocation of crucial resources for research projects, ultimately affecting the quality and reliability of research. In this paper, we present a model for providing flexible, cost-efficient institutional support for clinical and translational research data management and informatics, the research management team, and describe our initial experiences with deploying this model at our institution.

  17. Natural Disasters and Human Behavior: Explanation, Research and Models.

    Science.gov (United States)

    Glenn, Christopher

    1979-01-01

    A survey of published research determined that individual and group reactions to natural disasters differ greatly and depend partially on the predisaster personality. Four models are examined to explain individual and group reactions to natural disasters. A conglomerate model and a possible structure to future disaster research are offered.…

  18. A Career Success Model for Academics at Malaysian Research Universities

    Science.gov (United States)

    Abu Said, Al-Mansor; Mohd Rasdi, Roziah; Abu Samah, Bahaman; Silong, Abu Daud; Sulaiman, Suzaimah

    2015-01-01

    Purpose: The purpose of this paper is to develop a career success model for academics at the Malaysian research universities. Design/methodology/approach: Self-administered and online surveys were used for data collection among 325 academics from Malaysian research universities. Findings: Based on the analysis of structural equation modeling, the…

  19. Towards Sustainable Research Capacity Development and Research Ownership for Academic Institutes in Developing Countries: The Malawian Research Support Centre Model

    Science.gov (United States)

    Gomo, Exnevia; Kalilani, Linda; Mwapasa, Victor; Trigu, Chifundo; Phiri, Kamija; Schmidt, Joann; van Hensbroek, Michael Boele

    2011-01-01

    In lesser-developed African countries, the lack of institutionalised support for research, combined with limited career opportunities and poor remuneration, have contributed to weak research infrastructure and capacity, and a continuing brain drain to developed countries. Malawi's Research Support Centre (RSC) model is novel in that it provides a…

  20. Animal models for Gaucher disease research

    Directory of Open Access Journals (Sweden)

    Tamar Farfel-Becker

    2011-11-01

    Full Text Available Gaucher disease (GD, the most common lysosomal storage disorder (LSD, is caused by the defective activity of the lysosomal hydrolase glucocerebrosidase, which is encoded by the GBA gene. Generation of animal models that faithfully recapitulate the three clinical subtypes of GD has proved to be more of a challenge than first anticipated. The first mouse to be produced died within hours after birth owing to skin permeability problems, and mice with point mutations in Gba did not display symptoms correlating with human disease and also died soon after birth. Recently, conditional knockout mice that mimic some features of the human disease have become available. Here, we review the contribution of all currently available animal models to examining pathological pathways underlying GD and to testing the efficacy of new treatment modalities, and propose a number of criteria for the generation of more appropriate animal models of GD.

  1. A program of research in environmental modeling

    Science.gov (United States)

    1983-01-01

    A theoretical framework for the interpretation of satellite measurements of stratospheric temperature and trace gases is provided. This problem is quite complicated since the distributions of trace gases are dependent on dynamics and photochemistry. Therefore, the problem was attacked with models employing varying degrees of photochemical and dynamical complexity. The relationship between dynamics and trace gas transport and wave transience, dissipation and critical levels and the net (permanent) transport of trace gases, the role of photochemistry in trace gas transport, photochemistry and dynamics and altering the mean-zonal distribution of stratospheric ozone, and approximations to simplify the interpretation of observations and General Circulation Models are discussed.

  2. ANN-Models for Jaw-Research

    Science.gov (United States)

    2007-11-02

    Recently [5], the Peck-Langenbach-Hannam ( PLH ) dynamic model has been developed at U.B.C for the human jaw. It is based on published musculoskele- tal...of Abstract UU Number of Pages 4 Table 1: 3 sets from a 59–set of steady–state measurements of T(m;i) from the PLH simulator. m Set i=1 Set i=2 Set...Training sets can be obtained from the PLH model. The training sets will have special interest be- cause we want the network to generalize by predicting near

  3. Deterministic operations research models and methods in linear optimization

    CERN Document Server

    Rader, David J

    2013-01-01

    Uniquely blends mathematical theory and algorithm design for understanding and modeling real-world problems Optimization modeling and algorithms are key components to problem-solving across various fields of research, from operations research and mathematics to computer science and engineering. Addressing the importance of the algorithm design process. Deterministic Operations Research focuses on the design of solution methods for both continuous and discrete linear optimization problems. The result is a clear-cut resource for understanding three cornerstones of deterministic operations resear

  4. A Systematic Literature Review of Agile Maturity Model Research

    Directory of Open Access Journals (Sweden)

    Vaughan Henriques

    2017-02-01

    Full Text Available Background/Aim/Purpose: A commonly implemented software process improvement framework is the capability maturity model integrated (CMMI. Existing literature indicates higher levels of CMMI maturity could result in a loss of agility due to its organizational focus. To maintain agility, research has focussed attention on agile maturity models. The objective of this paper is to find the common research themes and conclusions in agile maturity model research. Methodology: This research adopts a systematic approach to agile maturity model research, using Google Scholar, Science Direct, and IEEE Xplore as sources. In total 531 articles were initially found matching the search criteria, which was filtered to 39 articles by applying specific exclusion criteria. Contribution:: The article highlights the trends in agile maturity model research, specifically bringing to light the lack of research providing validation of such models. Findings: Two major themes emerge, being the coexistence of agile and CMMI and the development of agile principle based maturity models. The research trend indicates an increase in agile maturity model articles, particularly in the latter half of the last decade, with concentrations of research coinciding with version updates of CMMI. While there is general consensus around higher CMMI maturity levels being incompatible with true agility, there is evidence of the two coexisting when agile is introduced into already highly matured environments. Future Research:\tFuture research direction for this topic should include how to attain higher levels of CMMI maturity using only agile methods, how governance is addressed in agile environments, and whether existing agile maturity models relate to improved project success.

  5. Research Models in Developmental Behavioral Toxicology.

    Science.gov (United States)

    Dietrich, Kim N.; Pearson, Douglas T.

    Developmental models currently used by child behavioral toxicologists and teratologists are inadequate to address current issues in these fields. Both child behavioral teratology and toxicology scientifically study the impact of exposure to toxic agents on behavior development: teratology focuses on prenatal exposure and postnatal behavior…

  6. A Theoretical Model for Selective Exposure Research.

    Science.gov (United States)

    Roloff, Michael E.; Noland, Mark

    This study tests the basic assumptions underlying Fishbein's Model of Attitudes by correlating an individual's selective exposure to types of television programs (situation comedies, family drama, and action/adventure) with the attitudinal similarity between individual attitudes and attitudes characterized on the programs. Twenty-three college…

  7. Animal models for HIV/AIDS research

    Science.gov (United States)

    Hatziioannou, Theodora; Evans, David T.

    2015-01-01

    The AIDS pandemic continues to present us with unique scientific and public health challenges. Although the development of effective antiretroviral therapy has been a major triumph, the emergence of drug resistance requires active management of treatment regimens and the continued development of new antiretroviral drugs. Moreover, despite nearly 30 years of intensive investigation, we still lack the basic scientific knowledge necessary to produce a safe and effective vaccine against HIV-1. Animal models offer obvious advantages in the study of HIV/AIDS, allowing for a more invasive investigation of the disease and for preclinical testing of drugs and vaccines. Advances in humanized mouse models, non-human primate immunogenetics and recombinant challenge viruses have greatly increased the number and sophistication of available mouse and simian models. Understanding the advantages and limitations of each of these models is essential for the design of animal studies to guide the development of vaccines and antiretroviral therapies for the prevention and treatment of HIV-1 infection. PMID:23154262

  8. Sharing Research Models: Using Software Engineering Practices for Facilitation.

    Science.gov (United States)

    Bryant, Stephanie P; Solano, Eric; Cantor, Susanna; Cooley, Philip C; Wagener, Diane K

    2011-03-01

    Increasingly, researchers are turning to computational models to understand the interplay of important variables on systems' behaviors. Although researchers may develop models that meet the needs of their investigation, application limitations-such as nonintuitive user interface features and data input specifications-may limit the sharing of these tools with other research groups. By removing these barriers, other research groups that perform related work can leverage these work products to expedite their own investigations. The use of software engineering practices can enable managed application production and shared research artifacts among multiple research groups by promoting consistent models, reducing redundant effort, encouraging rigorous peer review, and facilitating research collaborations that are supported by a common toolset. This report discusses three established software engineering practices- the iterative software development process, object-oriented methodology, and Unified Modeling Language-and the applicability of these practices to computational model development. Our efforts to modify the MIDAS TranStat application to make it more user-friendly are presented as an example of how computational models that are based on research and developed using software engineering practices can benefit a broader audience of researchers.

  9. The "Research Audit" Model: A Prototype for Data-Driven Discovery of Interdisciplinary Biomedical Research

    Science.gov (United States)

    Burnette, Margaret H.

    2015-01-01

    The increasing interdisciplinarity of scientific research creates both challenges and opportunities for librarians. The liaison model may be inadequate for supporting campus research that represents multiple disciplines and geographically dispersed departments. The identification of units, researchers, and projects is a first step in planning and…

  10. The "Research Audit" Model: A Prototype for Data-Driven Discovery of Interdisciplinary Biomedical Research

    Science.gov (United States)

    Burnette, Margaret H.

    2015-01-01

    The increasing interdisciplinarity of scientific research creates both challenges and opportunities for librarians. The liaison model may be inadequate for supporting campus research that represents multiple disciplines and geographically dispersed departments. The identification of units, researchers, and projects is a first step in planning and…

  11. Research of Home Information Technology Adoption Model

    Institute of Scientific and Technical Information of China (English)

    Ao Shan; Ren Weiyin; Lin Peishan; Tang Shoulian

    2008-01-01

    The Information Technology at Home has caught the attention of various industries such as IT, Home Appliances, Communication, and Real Estate. Based on the information technology acceptance theories and family consumption behaviors theories, this study summarized and analyzed four key belief variables i.e. Perceived Value, Perceived Risk, Perceived Cost and Perceived Ease of Use, which influence the acceptance of home information technology. The study also summaries three groups of external variables. They axe social, industrial, and family influence factors. The social influence factors include Subjective Norm; the industry factors include the Unification of Home Information Technological Standards, the Perfection of Home Information Industry Value Chain, and the Competitiveness of Home Information Industry; and the family factors include Family Income, Family Life Cycle and Family Educational Level. The study discusses the relationship among these external variables and cognitive variables. The study provides Home Information Technology Acceptance Model based on the Technology Acceptance Model and the characteristics of home information technology consumption.

  12. Feminist theory and nursing: an empowerment model for research.

    Science.gov (United States)

    Parker, B; McFarlane, J

    1991-03-01

    This article describes the use of the feminist process to empower nurses in conducting research. The criteria for feminist research, defined by Duffy, are applied to a research study that identifies the effects of physical abuse during pregnancy on maternal-infant outcomes. The authors describe the process of empowerment of the investigators through the use of a consortium model of research, the staff nurses who are conducting the interviews, and the research participants (pregnant women). The integration of feminist principles and nursing research is a process that merges similar beliefs and ideologies.

  13. POSITIVE LEADERSHIP MODELS: THEORETICAL FRAMEWORK AND RESEARCH

    Directory of Open Access Journals (Sweden)

    Javier Blanch, Francisco Gil

    2016-09-01

    Full Text Available The objective of this article is twofold; firstly, we establish the theoretical boundaries of positive leadership and the reasons for its emergence. It is related to the new paradigm of positive psychology that has recently been shaping the scope of organizational knowledge. This conceptual framework has triggered the development of the various forms of positive leadership (i.e. transformational, servant, spiritual, authentic, and positive. Although the construct does not seem univocally defined, these different types of leadership overlap and share a significant affinity. Secondly, we review the empirical evidence that shows the impact of positive leadership in organizations and we highlight the positive relationship between these forms of leadership and key positive organizational variables. Lastly, we analyse future research areas in order to further develop this concept.

  14. Research on the modeling method of soybean leafs structure simulation

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Leaf is one of the most important organs of soybean. The modeling of soybean leaf structure is useful to research of leaf function. The paper discussed it from two aspects that were distilling method of leaf profile and establishing method of leaf simulation model. It put forward basic method of soybean leaf digital process, and successfully established simulation model of soybean leaf structure based on L-system. It also solved a critical problem in the process of establishing soybean growth simulation model. And the research had guiding significance to establishment of soybean plant model.

  15. The research on HRM model of geosciences engineering perambulation enterprise

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Firstly,this paper defines the definition of geosciences engineering perambulation enterprise,which belongs to the knowledgeable enterprise;then,it summarizes the general HRM model presented by other researchers,based on those models,this paper builds a new HRM model of geosciences engineering perambulation enterprise.

  16. DESIGN OF THE RESEARCH INSTITUTION TYPE SITE MODEL

    Directory of Open Access Journals (Sweden)

    Natalia T. Zadorozhna

    2014-01-01

    Full Text Available The description of the model of site of research institution of NAPS of Ukraine (TSRI is presented. Goals and objectives оf the TSRI model are defined. Web 2.0 theoretical base for site development is considered, as well as described information environment, TSRI internet and intranet models. There are substantiated the site structure, design and site layout for research institution of NAPS of Ukraine. The example of the website of the Institute of Information Technologies and Learning Tools of the NAPS of Ukraine based on the TSRI model is showen. The technological aspects of the TSRI model are considered. There is given the scheme of internet-intranet environment to support scientific publications on pedagogical and psychological sciences. This paper is intended to web designers, researchers and administrative staff of research institutions.

  17. Modeling conflict : research methods, quantitative modeling, and lessons learned.

    Energy Technology Data Exchange (ETDEWEB)

    Rexroth, Paul E.; Malczynski, Leonard A.; Hendrickson, Gerald A.; Kobos, Peter Holmes; McNamara, Laura A.

    2004-09-01

    This study investigates the factors that lead countries into conflict. Specifically, political, social and economic factors may offer insight as to how prone a country (or set of countries) may be for inter-country or intra-country conflict. Largely methodological in scope, this study examines the literature for quantitative models that address or attempt to model conflict both in the past, and for future insight. The analysis concentrates specifically on the system dynamics paradigm, not the political science mainstream approaches of econometrics and game theory. The application of this paradigm builds upon the most sophisticated attempt at modeling conflict as a result of system level interactions. This study presents the modeling efforts built on limited data and working literature paradigms, and recommendations for future attempts at modeling conflict.

  18. Targets, models and challenges in osteoarthritis research

    Directory of Open Access Journals (Sweden)

    Sarah Thysen

    2015-01-01

    Full Text Available Osteoarthritis is a chronic degenerative disorder of the joint and represents one of the most common diseases worldwide. Its prevalence and severity are increasing owing to aging of the population, but treatment options remain largely limited to painkillers and anti-inflammatory drugs, which only provide symptomatic relief. In the late stages of the disease, surgical interventions are often necessary to partially restore joint function. Although the focus of osteoarthritis research has been originally on the articular cartilage, novel findings are now pointing to osteoarthritis as a disease of the whole joint, in which failure of different joint components can occur. In this Review, we summarize recent progress in the field, including data from novel ‘omics’ technologies and from a number of preclinical and clinical trials. We describe different in vitro and in vivo systems that can be used to study molecules, pathways and cells that are involved in osteoarthritis. We illustrate that a comprehensive and multisystem approach is necessary to understand the complexity and heterogeneity of the disease and to better guide the development of novel therapeutic strategies for osteoarthritis.

  19. Targets, models and challenges in osteoarthritis research.

    Science.gov (United States)

    Thysen, Sarah; Luyten, Frank P; Lories, Rik J U

    2015-01-01

    Osteoarthritis is a chronic degenerative disorder of the joint and represents one of the most common diseases worldwide. Its prevalence and severity are increasing owing to aging of the population, but treatment options remain largely limited to painkillers and anti-inflammatory drugs, which only provide symptomatic relief. In the late stages of the disease, surgical interventions are often necessary to partially restore joint function. Although the focus of osteoarthritis research has been originally on the articular cartilage, novel findings are now pointing to osteoarthritis as a disease of the whole joint, in which failure of different joint components can occur. In this Review, we summarize recent progress in the field, including data from novel 'omics' technologies and from a number of preclinical and clinical trials. We describe different in vitro and in vivo systems that can be used to study molecules, pathways and cells that are involved in osteoarthritis. We illustrate that a comprehensive and multisystem approach is necessary to understand the complexity and heterogeneity of the disease and to better guide the development of novel therapeutic strategies for osteoarthritis.

  20. Are invertebrates relevant models in ageing research?

    DEFF Research Database (Denmark)

    Erdogan, Cihan Suleyman; Hansen, Benni Winding; Vang, Ole

    2016-01-01

    Ageing is the organisms increased susceptibility to death, which is linked to accumulated damage in the cells and tissues. Ageing is a complex process regulated by crosstalk of various pathways in the cells. Ageing is highly regulated by the Target of Rapamycin (TOR) pathway activity. TOR...... the molecular mechanisms underlying the ageing process faster than mammal systems. Inhibition of the TOR pathway activity via either genetic manipulation or rapamycin increases lifespan profoundly in most invertebrate model organisms. This contribution will review the recent findings in invertebrates concerning...... the TOR pathway and effects of TOR inhibition by rapamycin on lifespan. Besides some contradictory results, the majority points out that rapamycin induces longevity. This suggests that administration of rapamycin in invertebrates is a promising tool for pursuing the scientific puzzle of lifespan...

  1. Use of Maximum Entropy Modeling in Wildlife Research

    Directory of Open Access Journals (Sweden)

    Roger A. Baldwin

    2009-11-01

    Full Text Available Maximum entropy (Maxent modeling has great potential for identifying distributions and habitat selection of wildlife given its reliance on only presence locations. Recent studies indicate Maxent is relatively insensitive to spatial errors associated with location data, requires few locations to construct useful models, and performs better than other presence-only modeling approaches. Further advances are needed to better define model thresholds, to test model significance, and to address model selection. Additionally, development of modeling approaches is needed when using repeated sampling of known individuals to assess habitat selection. These advancements would strengthen the utility of Maxent for wildlife research and management.

  2. Modeling Error in Quantitative Macro-Comparative Research

    Directory of Open Access Journals (Sweden)

    Salvatore J. Babones

    2015-08-01

    Full Text Available Much quantitative macro-comparative research (QMCR relies on a common set of published data sources to answer similar research questions using a limited number of statistical tools. Since all researchers have access to much the same data, one might expect quick convergence of opinion on most topics. In reality, of course, differences of opinion abound and persist. Many of these differences can be traced, implicitly or explicitly, to the different ways researchers choose to model error in their analyses. Much careful attention has been paid in the political science literature to the error structures characteristic of time series cross-sectional (TSCE data, but much less attention has been paid to the modeling of error in broadly cross-national research involving large panels of countries observed at limited numbers of time points. Here, and especially in the sociology literature, multilevel modeling has become a hegemonic – but often poorly understood – research tool. I argue that widely-used types of multilevel models, commonly known as fixed effects models (FEMs and random effects models (REMs, can produce wildly spurious results when applied to trended data due to mis-specification of error. I suggest that in most commonly-encountered scenarios, difference models are more appropriate for use in QMC.

  3. RECENT RELATED RESEARCH IN TECHNOLOGY ACCEPTANCE MODEL: A LITERATURE REVIEW

    Directory of Open Access Journals (Sweden)

    Shih-Chih Chen

    2011-10-01

    Full Text Available Technology Acceptance Model is widely applied to access users’ usage in various information system/information technology areas. Learning the critical role of Technology Acceptance Model can guide researchers to design different users’ interface for different online customers, and consequently achieve high user usage in different application areas. This study reviewed 24 studies to understand the past, now and future of Technology Acceptance Model. We discussed the related studies to clarify the extension of Technology Acceptance Model. Besides, the application areas are elaborated including electronic service, mobile data service, self-service technology, electronic learning and so on. Finally, the article concluded the conclusions and future research direction.

  4. Weather Research and Forecasting (WRF) Regional Atmospheric Model: Samoa

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Weather Research and Forecasting (WRF) mesoscale numerical weather prediction model 7-day hourly forecast for the region surrounding the islands of Samoa at...

  5. Weather Research and Forecasting (WRF) Regional Atmospheric Model: Guam

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Weather Research and Forecasting (WRF) mesoscale numerical weather prediction model 7-day hourly forecast for the region surrounding the island of Guam at...

  6. Weather Research and Forecasting (WRF) Regional Atmospheric Model: CNMI

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Weather Research and Forecasting (WRF) mesoscale numerical weather prediction model 7-day hourly forecast for the region surrounding the Commonwealth of the Northern...

  7. Weather Research and Forecasting (WRF) Regional Atmospheric Model: Oahu

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Weather Research and Forecasting (WRF) mesoscale numerical weather prediction model 3.5-day hourly forecast for the region surrounding the Hawaiian island of Oahu at...

  8. A Community Mentoring Model for STEM Undergraduate Research Experiences

    Science.gov (United States)

    Kobulnicky, Henry A.; Dale, Daniel A.

    2016-01-01

    This article describes a community mentoring model for UREs that avoids some of the common pitfalls of the traditional paradigm while harnessing the power of learning communities to provide young scholars a stimulating collaborative STEM research experience.

  9. a Review of Recent Research in Indoor Modelling & Mapping

    Science.gov (United States)

    Gunduz, M.; Isikdag, U.; Basaraner, M.

    2016-06-01

    Indoor modeling and mapping has been an active area of research in last 20 years in order to tackle the problems related to positioning and tracking of people and objects indoors, and provides many opportunities for several domains ranging from emergency response to logistics in micro urban spaces. The outputs of recent research in the field have been presented in several scientific publications and events primarily related to spatial information science and technology. This paper summarizes the outputs of last 10 years of research on indoor modeling and mapping within a proper classification which covers 7 areas, i.e. Information Acquisition by Sensors, Model Definition, Model Integration, Indoor Positioning and LBS, Routing & Navigation Methods, Augmented and Virtual Reality Applications, and Ethical Issues. Finally, the paper outlines the current and future research directions and concluding remarks.

  10. Methodology and models in erosion research: discussion and conclusions

    National Research Council Canada - National Science Library

    Shellis, R P; Ganss, C; Ren, Y; Zero, D T; Lussi, A

    2011-01-01

    .... The prospects for clinical trials are also discussed. All models in erosion research require a number of choices regarding experimental conditions, study design and measurement techniques, and these general aspects are discussed first...

  11. A REVIEW OF RECENT RESEARCH IN INDOOR MODELLING & MAPPING

    Directory of Open Access Journals (Sweden)

    M. Gunduz

    2016-06-01

    Full Text Available Indoor modeling and mapping has been an active area of research in last 20 years in order to tackle the problems related to positioning and tracking of people and objects indoors, and provides many opportunities for several domains ranging from emergency response to logistics in micro urban spaces. The outputs of recent research in the field have been presented in several scientific publications and events primarily related to spatial information science and technology. This paper summarizes the outputs of last 10 years of research on indoor modeling and mapping within a proper classification which covers 7 areas, i.e. Information Acquisition by Sensors, Model Definition, Model Integration, Indoor Positioning and LBS, Routing & Navigation Methods, Augmented and Virtual Reality Applications, and Ethical Issues. Finally, the paper outlines the current and future research directions and concluding remarks.

  12. The Healthy Aging Research Network: Modeling Collaboration for Community Impact.

    Science.gov (United States)

    Belza, Basia; Altpeter, Mary; Smith, Matthew Lee; Ory, Marcia G

    2017-03-01

    As the first Centers for Disease Control and Prevention (CDC) Prevention Research Centers Program thematic network, the Healthy Aging Research Network was established to better understand the determinants of healthy aging within older adult populations, identify interventions that promote healthy aging, and assist in translating research into sustainable community-based programs throughout the nation. To achieve these goals requires concerted efforts of a collaborative network of academic, community, and public health organizational partnerships. For the 2001-2014 Prevention Research Center funding cycles, the Healthy Aging Research Network conducted prevention research and promoted the wide use of practices known to foster optimal health. Organized around components necessary for successful collaborations (i.e., governance and infrastructure, shaping focus, community involvement, and evaluation and improvement), this commentary highlights exemplars that demonstrate the Healthy Aging Research Network's unique contributions to the field. The Healthy Aging Research Network's collaboration provided a means to collectively build capacity for practice and policy, reduce fragmentation and duplication in health promotion and aging research efforts, maximize the efficient use of existing resources and generate additional resources, and ultimately, create synergies for advancing the healthy aging agenda. This collaborative model was built upon a backbone organization (coordinating center); setting of common agendas and mutually reinforcing activities; and continuous communications. Given its successes, the Healthy Aging Research Network model could be used to create new and evaluate existing thematic networks to guide the translation of research into policy and practice.

  13. Agent Based Model of Young Researchers in Higher Education Institutions

    Directory of Open Access Journals (Sweden)

    Josip Stepanic

    2013-04-01

    Full Text Available Group of young researchers in higher education institutions in general perform demandable tasks with relatively high contribution to institutions’ and societies’ innovation production. In order to analyse in more details interaction among young researchers and diverse institutions in society, we aim toward developing the numerical simulation, agent-based model.This article presents foundations of the model, preliminary results of its simulation along with perspectives of its further development and improvements.

  14. Operational research models in warehouse design and planning

    OpenAIRE

    Geraldes, Carla A. S.; Carvalho, Sameiro; Pereira, Guilherme

    2010-01-01

    The design and operation of a warehouse involve many challenging decision problems. In this paper, a literature review on warehousing models is presented. Authors start with a hierarchy of decision problems encountered in setting up warehouse design and planning processes. Next, some operational research decision models and solution algorithms supporting decision making at each discussed level are presented. The aim is to link academic researchers and warehouse practitioners, explaining what ...

  15. Application of Logic Models in a Large Scientific Research Program

    Science.gov (United States)

    O'Keefe, Christine M.; Head, Richard J.

    2011-01-01

    It is the purpose of this article to discuss the development and application of a logic model in the context of a large scientific research program within the Commonwealth Scientific and Industrial Research Organisation (CSIRO). CSIRO is Australia's national science agency and is a publicly funded part of Australia's innovation system. It conducts…

  16. Application of Logic Models in a Large Scientific Research Program

    Science.gov (United States)

    O'Keefe, Christine M.; Head, Richard J.

    2011-01-01

    It is the purpose of this article to discuss the development and application of a logic model in the context of a large scientific research program within the Commonwealth Scientific and Industrial Research Organisation (CSIRO). CSIRO is Australia's national science agency and is a publicly funded part of Australia's innovation system. It conducts…

  17. Experiences with the Capability Maturity Model in a research environment

    NARCIS (Netherlands)

    Velden, van der M.J.; Vreke, J.; Wal, van der B.; Symons, A.

    1996-01-01

    The project described here was aimed at evaluating the Capability Maturity Model (CMM) in the context of a research organization. Part of the evaluation was a standard CMM assessment. It was found that CMM could be applied to a research organization, although its five maturity levels were considered

  18. Organization as Information Processing Systems. Toward a Model of the Research Factors Associated with Significant Research Outcomes.

    Science.gov (United States)

    1986-04-01

    and %- , during research projects that were related to research outcomes. The Ambidextrous model, which includes both organic and mechanistic research...to make choices with greater li4kelihood for innovative outcomes. p A potential side benefit from better knowledge of the research process * maY...aspect of the research process. The models are referred to respectively as the Davis model, the Antecedents model, and the Ambidextrous model. These

  19. Conceptual Frameworks in the Doctoral Research Process: A Pedagogical Model

    Science.gov (United States)

    Berman, Jeanette; Smyth, Robyn

    2015-01-01

    This paper contributes to consideration of the role of conceptual frameworks in the doctoral research process. Through reflection on the two authors' own conceptual frameworks for their doctoral studies, a pedagogical model has been developed. The model posits the development of a conceptual framework as a core element of the doctoral…

  20. Yeast and filamentous fungi as model organisms in microbody research

    NARCIS (Netherlands)

    Klei, Ida J. van der; Veenhuis, Marten

    2006-01-01

    Yeast and filamentous fungi are important model organisms in microbody research. The value of these organisms as models for higher eukaryotes is underscored by the observation that the principles of various aspects of microbody biology are strongly conserved from lower to higher eukaryotes. This has

  1. Changing Models for Researching Pedagogy with Information and Communications Technologies

    Science.gov (United States)

    Webb, M.

    2013-01-01

    This paper examines changing models of pedagogy by drawing on recent research with teachers and their students as well as theoretical developments. In relation to a participatory view of learning, the paper reviews existing pedagogical models that take little account of the use of information and communications technologies as well as those that…

  2. Conceptual Frameworks and Research Models on Resilience in Leadership

    OpenAIRE

    Janet Ledesma

    2014-01-01

    The purpose of this article was to discuss conceptual frameworks and research models on resilience theory. The constructs of resilience, the history of resilience theory, models of resilience, variables of resilience, career resilience, and organizational resilience will be examined and discussed as they relate to leadership development. The literature demonstrates that there is a direct relationship between the stress...

  3. Conceptual Model of Artifacts for Design Science Research

    DEFF Research Database (Denmark)

    Bækgaard, Lars

    2015-01-01

    We present a conceptual model of design science research artifacts. The model views an artifact at three levels. At the artifact level a selected artifact is viewed as a combination of material and immaterial aspects and a set of representations hereof. At the design level the selected artifact...

  4. Dental Biofilm and Laboratory Microbial Culture Models for Cariology Research

    Directory of Open Access Journals (Sweden)

    Ollie Yiru Yu

    2017-06-01

    Full Text Available Dental caries form through a complex interaction over time among dental plaque, fermentable carbohydrate, and host factors (including teeth and saliva. As a key factor, dental plaque or biofilm substantially influence the characteristic of the carious lesions. Laboratory microbial culture models are often used because they provide a controllable and constant environment for cariology research. Moreover, they do not have ethical problems associated with clinical studies. The design of the microbial culture model varies from simple to sophisticated according to the purpose of the investigation. Each model is a compromise between the reality of the oral cavity and the simplification of the model. Researchers, however, can still obtain meaningful and useful results from the models they select. Laboratory microbial culture models can be categorized into a closed system and an open system. Models in the closed system have a finite supply of nutrients, and are also simple and cost-effective. Models in the open system enabled the supply of a fresh culture medium and the removal of metabolites and spent culture liquid simultaneously. They provide better regulation of the biofilm growth rate than the models in the closed system. This review paper gives an overview of the dental plaque biofilm and laboratory microbial culture models used for cariology research.

  5. Bridging Research, Practice, and Policy: The "Evidence Academy" Conference Model.

    Science.gov (United States)

    Rohweder, Catherine L; Laping, Jane L; Diehl, Sandra J; Moore, Alexis A; Isler, Malika Roman; Scott, Jennifer Elissa; Enga, Zoe Kaori; Black, Molly C; Dave, Gaurav; Corbie-Smith, Giselle; Melvin, Cathy L

    2016-01-01

    Innovative models to facilitate more rapid uptake of research findings into practice are urgently needed. Community members who engage in research can accelerate this process by acting as adoption agents. We implemented an Evidence Academy conference model bringing together researchers, health care professionals, advocates, and policy makers across North Carolina to discuss high-impact, life-saving study results. The overall goal is to develop dissemination and implementation strategies for translating evidence into practice and policy. Each 1-day, single-theme, regional meeting focuses on a leading community-identified health priority. The model capitalizes on the power of diverse local networks to encourage broad, common awareness of new research findings. Furthermore, it emphasizes critical reflection and active group discussion on how to incorporate new evidence within and across organizations, health care systems, and communities. During the concluding session, participants are asked to articulate action plans relevant to their individual interests, work setting, or area of expertise.

  6. Research on Dynamic Model of the Human Body

    Institute of Scientific and Technical Information of China (English)

    ZHANG Chun-lin; WANG Guang-quan; LU Dun-yong

    2005-01-01

    After summarizing the current situation of the research on human body modeling, a new dynamic model containing 5 equivalent masses has been proposed and the corresponding dynamic equations has been deduced too. By using this new model, more detailed information about the situation of the human body under impact and vibration can be obtained. The new model solves the problem that transmission functions of forces inside the human body can't be deduced by using 3-equivalent-mass model. It will find its usage in many applications.

  7. Research on the User Interest Modeling of Personalized Search Engine

    Institute of Scientific and Technical Information of China (English)

    LI Zhengwei; XIA Shixiong; NIU Qiang; XIA Zhanguo

    2007-01-01

    At present, how to enable Search Engine to construct user personal interest model initially, master user's personalized information timely and provide personalized services accurately have become the hotspot in the research of Search Engine area.Aiming at the problems of user model's construction and combining techniques of manual customization modeling and automatic analytical modeling, a User Interest Model (UIM) is proposed in the paper. On the basis of it, the corresponding establishment and update algorithms of User Interest Profile (UIP) are presented subsequently. Simulation tests proved that the UIM proposed and corresponding algorithms could enhance the retrieval precision effectively and have superior adaptability.

  8. Can Participatory Action Research Create Value for Business Model Innovation?

    DEFF Research Database (Denmark)

    Sparre, Mogens; Rasmussen, Ole Horn; Fast, Alf Michael

    Abstract: Participatory Action Research (PAR) has a longer academic history compared with the idea of business models (BMs). This paper indicates how industries gain by using the combined methodology. The research question "Can participatory action research create value for Business Model...... Innovation (BMI)?” – has been investigated from five different perspectives based upon The Business Model Cube and The Where to Look Model. Using both established and newly developed tools the paper presents how. Theory and data from two cases are presented and it is demonstrated how industry increase...... their monetary and/or non-monetary value creation doing BMI based upon PAR. The process is essential and using the methodology of PAR creates meaning. Behind the process, the RAR methodology and its link to BM and BMI may contribute to theory construction and creation of a common language in academia around...

  9. Animal models of frailty: current applications in clinical research.

    Science.gov (United States)

    Kane, Alice E; Hilmer, Sarah N; Mach, John; Mitchell, Sarah J; de Cabo, Rafael; Howlett, Susan E

    2016-01-01

    The ethical, logistical, and biological complications of working with an older population of people inherently limits clinical studies of frailty. The recent development of animal models of frailty, and tools for assessing frailty in animal models provides an invaluable opportunity for frailty research. This review summarizes currently published animal models of frailty including the interleukin-10 knock-out mouse, the mouse frailty phenotype assessment tool, and the mouse clinical frailty index. It discusses both current and potential roles of these models in research into mechanisms of frailty, interventions to prevent/delay frailty, and the effect of frailty on outcomes. Finally, this review discusses some of the challenges and opportunities of translating research findings from animals to humans.

  10. Research on Modeling of Genetic Networks Based on Information Measurement

    Institute of Scientific and Technical Information of China (English)

    ZHANG Guo-wei; SHAO Shi-huang; ZHANG Ying; LI Hai-ying

    2006-01-01

    As the basis of network of biology organism, the genetic network is concerned by many researchers.Current modeling methods to genetic network, especially the Boolean networks modeling method are analyzed. For modeling the genetic network, the information theory is proposed to mining the relations between elements in network. Through calculating the values of information entropy and mutual entropy in a case, the effectiveness of the method is verified.

  11. Hydrodynamics Research on Amphibious Vehicle Systems:Modeling Theory

    Institute of Scientific and Technical Information of China (English)

    JU Nai-jun

    2006-01-01

    For completing the hydrodynamics software development and the engineering application research on the amphibious vehicle systems, hydrodynamic modeling theory of the amphibious vehicle systems is elaborated, which includes to build up the dynamic system model of amphibious vehicle motion on water, gun tracking-aiming-firing, bullet hit and armored check-target, gunner operating control, and the simulation computed model of time domain for random sea wave.

  12. Research progress on animal models of Alzheimer's disease

    Directory of Open Access Journals (Sweden)

    Wen DONG

    2015-08-01

    Full Text Available Alzheimer's disease (AD is a degenerative disease of the central nervous system, and its pathogenesis is complex. Animal models play an important role in study on pathogenesis and treatment of AD. This paper summarized methods of building models, observation on animal models and evaluation index in recent years, so as to provide related evidence for basic and clinical research in future. DOI: 10.3969/j.issn.1672-6731.2015.08.003

  13. The Sheep as an Animal Model in Orthopaedic Research

    OpenAIRE

    J.C. Potes; Reis, J.; Capela e Silva, Fernando; Relvas, C; A.S. Cabrita; Simões, J A

    2008-01-01

    The use of sheep as model in remodeling process in cancelous and cortical bone for the assessment of new orthopaedic biomaterials and implants, in biomechanical studies and as model for tissue-engineered bone constructs has been described in the literature. Sheep are a well accepted model for in vivo studies in orthopaedic research to address the biomechanical, biochemical and histological processes of bone biology, due to similarities with humans in weight, size, bone and joint structure and...

  14. RECENT RELATED RESEARCH IN TECHNOLOGY ACCEPTANCE MODEL: A LITERATURE REVIEW

    OpenAIRE

    Shih-Chih Chen; Shing-Han Li; Chien-Yi Li

    2011-01-01

    Technology Acceptance Model is widely applied to access users’ usage in various information system/information technology areas. Learning the critical role of Technology Acceptance Model can guide researchers to design different users’ interface for different online customers, and consequently achieve high user usage in different application areas. This study reviewed 24 studies to understand the past, now and future of Technology Acceptance Model. We discussed the related studies to ...

  15. Research on Digital Models for Product Design and Manufacture

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    CAD/CAM integrate technology has been drawn to much a ttention and becomes one of the focus of the international academic and commerci al research, Through efforts nearly 10 years, remarkable progress has been made in the 3-dimension feature parametric modeling. UG, SOLIDWORK and MDT apply the se technology with respective features. However, no distinct development has bee n made in the digital models from geometric feature to manufacture feature. Prod uct information expression and the basic model frame ...

  16. International Research Workshop on Integrating GIS and Environmental Modeling: Problems, Prospects, and Research Needs

    Science.gov (United States)

    Parks, Bradley

    2001-01-01

    The 4th International Conference on Integrating GIS and Environmental Modeling (GIS/EM4) was convened in Banff, Canada, September 2-8, 2000 at The Banff Centre for Conferences. The meeting's purpose, like it's predecessors was to reformulate, each three to four years, the collaborative research agenda for integrating spatio-temporal analysis with environmental simulation modeling.

  17. The Job Demands–Resources model: Challenges for future research

    Directory of Open Access Journals (Sweden)

    Evangelia Demerouti

    2011-05-01

    Full Text Available Motivation: The motivation of this overview is to present the state of the art of Job Demands–Resources (JD–R model whilst integrating the various contributions to the special issue.Research purpose: To provide an overview of the JD–R model, which incorporates many possible working conditions and focuses on both negative and positive indicators of employee well-being. Moreover, the studies of the special issue were introduced.Research design: Qualitative and quantitative studies on the JD–R model were reviewed to enlighten the health and motivational processes suggested by the model.Main findings: Next to the confirmation of the two suggested processes of the JD–R model, the studies of the special issue showed that the model can be used to predict work-place bullying, incidences of upper respiratory track infection, work-based identity, and early retirement intentions. Moreover, whilst psychological safety climate could be considered as a hypothetical precursor of job demands and resources, compassion satisfaction moderated the health process of the model.Contribution/value-add: The findings of previous studies and the studies of the special issue were integrated in the JD–R model that can be used to predict well-being and performance at work. New avenues for future research were suggested.Practical/managerial implications: The JD–R model is a framework that can be used for organisations to improve employee health and motivation, whilst simultaneously improving various organisational outcomes.

  18. Use of deterministic models in sports and exercise biomechanics research.

    Science.gov (United States)

    Chow, John W; Knudson, Duane V

    2011-09-01

    A deterministic model is a modeling paradigm that determines the relationships between a movement outcome measure and the biomechanical factors that produce such a measure. This review provides an overview of the use of deterministic models in biomechanics research, a historical summary of this research, and an analysis of the advantages and disadvantages of using deterministic models. The deterministic model approach has been utilized in technique analysis over the last three decades, especially in swimming, athletics field events, and gymnastics. In addition to their applications in sports and exercise biomechanics, deterministic models have been applied successfully in research on selected motor skills. The advantage of the deterministic model approach is that it helps to avoid selecting performance or injury variables arbitrarily and to provide the necessary theoretical basis for examining the relative importance of various factors that influence the outcome of a movement task. Several disadvantages of deterministic models, such as the use of subjective measures for the performance outcome, were discussed. It is recommended that exercise and sports biomechanics scholars should consider using deterministic models to help identify meaningful dependent variables in their studies.

  19. [Research advances in animal models of intervertebral disc degeneration].

    Science.gov (United States)

    Zhang, Wenli; Liu, Hao; Li, Tanzhu

    2007-11-01

    To review the research advances in animal models of human disc degeneration. The relative articles in recent years were extensively reviewed. Studies both at home and abroad were analyzed and classified. The advantages and disadvantages of each method were compared. Studies were classified as either experimentally induced models or spontaneous models. The induced models were subdivided as mechanical (alteration of forces on the normal disc), structural (injury or chemical alteration) and genetically induced models. Spontaneous models included those animals that naturally developed degenerative disc disease. Animal model of intervertebral disc degeneration is an important path for revealing the pathogenesis of human disc degeneration, and play an important role in testing novel interventions. With recent advances in the relevance of animal models and humans, it has a great prospect in study of human disc degeneration.

  20. Research on Digital Product Modeling Key Technologies of Digital Manufacturing

    Institute of Scientific and Technical Information of China (English)

    DING Guoping; ZHOU Zude; HU Yefa; ZHAO Liang

    2006-01-01

    With the globalization and diversification of the market and the rapid development of Information Technology (IT) and Artificial Intelligence (AI), the digital revolution of manufacturing is coming. One of the key technologies in digital manufacturing is product digital modeling. This paper firstly analyzes the information and features of the product digital model during each stage in the product whole lifecycle, then researches on the three critical technologies of digital modeling in digital manufacturing-product modeling, standard for the exchange of product model data and digital product data management. And the potential signification of the product digital model during the process of digital manufacturing is concluded-product digital model integrates primary features of each stage during the product whole lifecycle based on graphic features, applies STEP as data exchange mechanism, and establishes PDM system to manage the large amount, complicated and dynamic product data to implement the product digital model data exchange, sharing and integration.

  1. Translational research challenges: finding the right animal models.

    Science.gov (United States)

    Prabhakar, Sharma

    2012-12-01

    Translation of scientific discoveries into meaningful human applications, particularly novel therapies of human diseases, requires development of suitable animal models. Experimental approaches to test new drugs in preclinical phases often necessitated animal models that not only replicate human disease in etiopathogenesis and pathobiology but also biomarkers development and toxicity prediction. Whereas the transgenic and knockout techniques have revolutionized manipulation of rodents and other species to get greater insights into human disease pathogenesis, we are far from generating ideal animal models of most human disease states. The challenges in using the currently available animal models for translational research, particularly for developing potentially new drugs for human disease, coupled with the difficulties in toxicity prediction have led some researchers to develop a scoring system for translatability. These aspects and the challenges in selecting an animal model among those that are available to study human disease pathobiology and drug development are the topics covered in this detailed review.

  2. A TEXT MINING RESEARCH BASED ON LDA TOPIC MODELLING

    Directory of Open Access Journals (Sweden)

    Zhou Tong

    2016-05-01

    Full Text Available A Large number of digital text information is generated every day. Effectively searching, managing and exploring the text data has become a main task. In this paper, we first represent an introduction to text mining and a probabilistic topic model Latent Dirichlet allocation. Then two experiments are proposed - Wikipedia articles and users’ tweets topic modelling. The former one builds up a document topic model, aiming to a topic perspective solution on searching, exploring and recommending articles. The latter one sets up a user topic model, providing a full research and analysis over Twitter users’ interest. The experiment process including data collecting, data pre-processing and model training is fully documented and commented. Further more, the conclusion and application of this paper could be a useful computation tool for social and business research.

  3. Legacy model integration for enhancing hydrologic interdisciplinary research

    Science.gov (United States)

    Dozier, A.; Arabi, M.; David, O.

    2013-12-01

    Many challenges are introduced to interdisciplinary research in and around the hydrologic science community due to advances in computing technology and modeling capabilities in different programming languages, across different platforms and frameworks by researchers in a variety of fields with a variety of experience in computer programming. Many new hydrologic models as well as optimization, parameter estimation, and uncertainty characterization techniques are developed in scripting languages such as Matlab, R, Python, or in newer languages such as Java and the .Net languages, whereas many legacy models have been written in FORTRAN and C, which complicates inter-model communication for two-way feedbacks. However, most hydrologic researchers and industry personnel have little knowledge of the computing technologies that are available to address the model integration process. Therefore, the goal of this study is to address these new challenges by utilizing a novel approach based on a publish-subscribe-type system to enhance modeling capabilities of legacy socio-economic, hydrologic, and ecologic software. Enhancements include massive parallelization of executions and access to legacy model variables at any point during the simulation process by another program without having to compile all the models together into an inseparable 'super-model'. Thus, this study provides two-way feedback mechanisms between multiple different process models that can be written in various programming languages and can run on different machines and operating systems. Additionally, a level of abstraction is given to the model integration process that allows researchers and other technical personnel to perform more detailed and interactive modeling, visualization, optimization, calibration, and uncertainty analysis without requiring deep understanding of inter-process communication. To be compatible, a program must be written in a programming language with bindings to a common

  4. Advanced parallel programming models research and development opportunities.

    Energy Technology Data Exchange (ETDEWEB)

    Wen, Zhaofang.; Brightwell, Ronald Brian

    2004-07-01

    There is currently a large research and development effort within the high-performance computing community on advanced parallel programming models. This research can potentially have an impact on parallel applications, system software, and computing architectures in the next several years. Given Sandia's expertise and unique perspective in these areas, particularly on very large-scale systems, there are many areas in which Sandia can contribute to this effort. This technical report provides a survey of past and present parallel programming model research projects and provides a detailed description of the Partitioned Global Address Space (PGAS) programming model. The PGAS model may offer several improvements over the traditional distributed memory message passing model, which is the dominant model currently being used at Sandia. This technical report discusses these potential benefits and outlines specific areas where Sandia's expertise could contribute to current research activities. In particular, we describe several projects in the areas of high-performance networking, operating systems and parallel runtime systems, compilers, application development, and performance evaluation.

  5. Fifteen Years of Research on Business Model Innovation

    DEFF Research Database (Denmark)

    Foss, Nicolai Juul; Saebi, Tina

    2017-01-01

    Over the last 15 years, business model innovation (BMI) has gained an increasing amount of attention in management research and among practitioners. The emerging BMI literature addresses an important phenomenon but lacks theoretical underpinning, and empirical inquiry is not cumulative. Thus...... research and show how the complexity theory, innovation, and other streams of literature can help overcome many of the gaps in the BMI literature....

  6. The Laboratory Rat as an Animal Model for Osteoporosis Research

    OpenAIRE

    Lelovas, Pavlos P; Xanthos, Theodoros T.; Thoma, Sofia E; Lyritis, George P; Dontas, Ismene A

    2008-01-01

    Osteoporosis is an important systemic disorder, affecting mainly Caucasian women, with a diverse and multifactorial etiology. A large variety of animal species, including rodents, rabbits, dogs, and primates, have been used as animal models in osteoporosis research. Among these, the laboratory rat is the preferred animal for most researchers. Its skeleton has been studied extensively, and although there are several limitations to its similarity to the human condition, these can be overcome th...

  7. Modeling Complex Nesting Structures in International Business Research

    DEFF Research Database (Denmark)

    Nielsen, Bo Bernhard; Nielsen, Sabina

    2013-01-01

    International business (IB) phenomena often involve complex relationships between factors at different levels. Multinational corporations (MNCs) are influenced both by different country and industry environments which may have independent as well as interactive effects on MNC performance. While...... of analysis may yield novel insights to IB research. The results have implications for IB research in its pursuit of an integrative approach to understanding the multilevel determinants of firm internationalization and performance. The paper further illustrates the importance of adequately modeling crossed...

  8. Acoel and platyhelminth models for stem-cell research

    Science.gov (United States)

    2010-01-01

    Acoel and platyhelminth worms are particularly attractive invertebrate models for stem-cell research because their bodies are continually renewed from large pools of somatic stem cells. Several recent studies, including one in BMC Developmental Biology, are beginning to reveal the cellular dynamics and molecular basis of stem-cell function in these animals. See research article http://www.biomedcentral.com/1471-213X/9/69. PMID:20236484

  9. Modelling Research on Consumer Attitude Toward Car Brands

    OpenAIRE

    Vlad (Uta) Daniela Steluta

    2014-01-01

    A quantitative research of consumer behaviour usually takes under consideration the following processes: perception, information/ learning, motivation, attitude and actual behaviour. From all this dynamic processes that define consumer behaviour, attitude is the one process relatively stable in time, with a very strong affective and cognitive component. In attempt to model attitude research one need to take under consideration external factors that influence attitude formation as well as this...

  10. Conceptual Model of Artifacts for Design Science Research

    DEFF Research Database (Denmark)

    Bækgaard, Lars

    2015-01-01

    We present a conceptual model of design science research artifacts. The model views an artifact at three levels. At the artifact level a selected artifact is viewed as a combination of material and immaterial aspects and a set of representations hereof. At the design level the selected artifact...... is viewed through its design in terms of descriptions, models, prototypes etc. At the knowledge level the selected artifact is viewed through ontologies, categories and various types of relevant knowledge. The model is based on description...

  11. Conceptual Model of Artifacts for Design Science Research

    DEFF Research Database (Denmark)

    Bækgaard, Lars

    2015-01-01

    We present a conceptual model of design science research artifacts. The model views an artifact at three levels. At the artifact level a selected artifact is viewed as a combination of material and immaterial aspects and a set of representations hereof. At the design level the selected artifact...... is viewed through its design in terms of descriptions, models, prototypes etc. At the knowledge level the selected artifact is viewed through ontologies, categories and various types of relevant knowledge. The model is based on description...

  12. WRF-Fire: coupled weather-wildland fire modeling with the weather research and forecasting model

    Science.gov (United States)

    Janice L. Coen; Marques Cameron; John Michalakes; Edward G. Patton; Philip J. Riggan; Kara M. Yedinak

    2012-01-01

    A wildland fire behavior module (WRF-Fire) was integrated into the Weather Research and Forecasting (WRF) public domain numerical weather prediction model. The fire module is a surface fire behavior model that is two-way coupled with the atmospheric model. Near-surface winds from the atmospheric model are interpolated to a finer fire grid and used, with fuel properties...

  13. DART: New Research Using Ensemble Data Assimilation in Geophysical Models

    Science.gov (United States)

    Anderson, Jeffrey; Raeder, Kevin; Hoar, Tim; Collins, Nancy; Romine, Glen; Barre, Jerome; Gaubert, Benjamin; Arellano, Ave; Wuerth, Stephanie

    2016-04-01

    The Data Assimilation Research Testbed (DART) is a community facility for ensemble data assimilation developed and supported by the National Center for Atmospheric Research. DART provides a comprehensive suite of software, documentation, examples and tutorials that can be used for ensemble data assimilation research, operations, and education. Scientists and software engineers from the Data Assimilation Research Section at NCAR are available to actively support DART users who want to use existing DART products or develop their own new applications. Current DART users range from university professors teaching data assimilation, to individual graduate students working with simple models, through national laboratories doing operational prediction with large state-of-the-art models. DART runs efficiently on many computational platforms ranging from laptops through thousands of cores on the newest supercomputers. This poster focuses on several recent research activities using DART with geophysical models: 1). Using CAM/DART to understand whether OCO-2 Total Precipitable Water observations can be useful in numerical weather prediction. 2). Impacts of the synergistic use of Infra-red CO retrievals (MOPITT, IASI) in CAMCHEM/DART assimilations. 3). Assimilation and Analysis of Observations of Amazonian Biomass Burning Emissions by MOPITT (aerosol optical depth), MODIS (carbon monoxide) and MISR (plume height). 4). Long term evaluation of the chemical response of MOPITT-CO assimilation in CAM-CHEM/DART OSSEs for satellite planning and emission inversion capabilities. 5). Improved forward observation operators for land models that have multiple land use/land cover segments in a single grid cell, enabling studies of the inherent variability in a single gridcell. Future enhancements are also discussed: 1). The CICE component of the Community Earth System Model will be added to the existing suite of components, which can be used for data assimilation. 2). Fully coupled

  14. Innovative research of AD HOC network mobility model

    Science.gov (United States)

    Chen, Xin

    2017-08-01

    It is difficult for researchers of AD HOC network to conduct actual deployment during experimental stage as the network topology is changeable and location of nodes is unfixed. Thus simulation still remains the main research method of the network. Mobility model is an important component of AD HOC network simulation. It is used to describe the movement pattern of nodes in AD HOC network (including location and velocity, etc.) and decides the movement trail of nodes, playing as the abstraction of the movement modes of nodes. Therefore, mobility model which simulates node movement is an important foundation for simulation research. In AD HOC network research, mobility model shall reflect the movement law of nodes as truly as possible. In this paper, node generally refers to the wireless equipment people carry. The main research contents include how nodes avoid obstacles during movement process and the impacts of obstacles on the mutual relation among nodes, based on which a Node Self Avoiding Obstacle, i.e. NASO model is established in AD HOC network.

  15. Recent advances in animal model experimentation in autism research.

    Science.gov (United States)

    Tania, Mousumi; Khan, Md Asaduzzaman; Xia, Kun

    2014-10-01

    Autism, a lifelong neuro-developmental disorder is a uniquely human condition. Animal models are not the perfect tools for the full understanding of human development and behavior, but they can be an important place to start. This review focused on the recent updates of animal model research in autism. We have reviewed the publications over the last three decades, which are related to animal model study in autism. Animal models are important because they allow researchers to study the underlying neurobiology in a way that is not possible in humans. Improving the availability of better animal models will help the field to increase the development of medicines that can relieve disabling symptoms. Results from the therapeutic approaches are encouraging remarkably, since some behavioral alterations could be reversed even when treatment was performed on adult mice. Finding an animal model system with similar behavioral tendencies as humans is thus vital for understanding the brain mechanisms, supporting social motivation and attention, and the manner in which these mechanisms break down in autism. The ongoing studies should therefore increase the understanding of the biological alterations associated with autism as well as the development of knowledge-based treatments therapy for those struggling with autism. In this review, we have presented recent advances in research based on animal models of autism, raising hope for understanding the disease biology for potential therapeutic intervention to improve the quality of life of autism individuals.

  16. Modeling as a research tool in poultry science.

    Science.gov (United States)

    Gous, R M

    2014-01-01

    The World's Poultry Science Association (WPSA) is a long-established and unique organization that strives to advance knowledge and understanding of all aspects of poultry science and the poultry industry. Its 3 main aims are education, organization, and research. The WPSA Keynote Lecture, titled "Modeling as a research tool in poultry science," addresses 2 of these aims, namely, the value of modeling in research and education. The role of scientists is to put forward and then to test theories. These theories, or models, may be simple or highly complex, but they are aimed at improving our understanding of a system or the interaction between systems. In developing a model, the scientist must take into account existing knowledge, and in this process gaps in our knowledge of a system are identified. Useful ideas for research are generated in this way, and experiments may be designed specifically to address these issues. The resultant models become more accurate and more useful, and can be used in education and extension as a means of explaining many of the complex issues that arise in poultry science.

  17. Developing Research Agendas on Whole School Improvement Models: The Model Providers' Perspective

    Science.gov (United States)

    Shambaugh, Larisa; Graczewski, Cheryl; Therriault, Susan Bowles; Darwin, Marlene J.

    2007-01-01

    The current education policy environment places a heavy emphasis on scientifically based research. This article examines how whole school improvement models approach the development of a research agenda, including what influences and challenges model providers face in implementing their agenda. Responses also detail the advantages and…

  18. Two-dimensional Numerical Modeling Research on Continent Subduction Dynamics

    Institute of Scientific and Technical Information of China (English)

    WANG Zhimin; XU Bei; ZHOU Yaoqi; XU Hehua; HUANG Shaoying

    2004-01-01

    Continent subduction is one of the hot research problems in geoscience. New models presented here have been set up and two-dimensional numerical modeling research on the possibility of continental subduction has been made with the finite element software, ANSYS, based on documentary evidence and reasonable assumptions that the subduction of oceanic crust has occurred, the subduction of continental crust can take place and the process can be simplified to a discontinuous plane strain theory model. The modeling results show that it is completely possible for continental crust to be subducted to a depth of 120 km under certain circumstances and conditions. At the same time, the simulations of continental subduction under a single dynamical factor have also been made, including the pull force of the subducted oceanic lithosphere, the drag force connected with mantle convection and the push force of the mid-ocean ridge. These experiments show that the drag force connected with mantle convection is critical for continent subduction.

  19. Models for Estimating Research and Development Manpower in Navy Laboratories

    Science.gov (United States)

    1988-10-01

    Mathematics Policy Research, Inc. under subcontract to Mathtech, Inc. of Falls Church, Virginia, under contract N00123-83- D-0520. The contracting officer’s...primary objective of forecasting staffing requirements for the SPAWAR R&D Centers. Besides changing policy variables and projecting the effects on...known values. For NOSC, NSWC, DTNSRDC, NUSC, and NCSC, the models were used to backcast FY83. For NADC, the model was used to backcast FY84. For

  20. A biobank management model applicable to biomedical research

    Directory of Open Access Journals (Sweden)

    Patenaude Johane

    2006-04-01

    Full Text Available Abstract Background The work of Research Ethics Boards (REBs, especially when involving genetics research and biobanks, has become more challenging with the growth of biotechnology and biomedical research. Some REBs have even rejected research projects where the use of a biobank with coded samples was an integral part of the study, the greatest fear being the lack of participant protection and uncontrolled use of biological samples or related genetic data. The risks of discrimination and stigmatization are a recurrent issue. In light of the increasing interest in biomedical research and the resulting benefits to the health of participants, it is imperative that practical solutions be found to the problems associated with the management of biobanks: namely, protecting the integrity of the research participants, as well as guaranteeing the security and confidentiality of the participant's information. Methods We aimed to devise a practical and efficient model for the management of biobanks in biomedical research where a medical archivist plays the pivotal role as a data-protection officer. The model had to reduce the burden placed on REBs responsible for the evaluation of genetics projects and, at the same time, maximize the protection of research participants. Results The proposed model includes the following: 1 a means of protecting the information in biobanks, 2 offers ways to provide follow-up information requested about the participants, 3 protects the participant's confidentiality and 4 adequately deals with the ethical issues at stake in biobanking. Conclusion Until a governmental governance body is established in Quebec to guarantee the protection of research participants and establish harmonized guidelines for the management of biobanks in medical research, it is definitely up to REBs to find solutions that the present lack of guidelines poses. The model presented in this article offers a practical solution on a day-to-day basis for REBs

  1. Public involvement in breast cancer research: an analysis and model for future research.

    Science.gov (United States)

    McCormick, Sabrina; Brody, Julia; Brown, Phil; Polk, Ruth

    2004-01-01

    Public involvement in health program planning has been taking place for many years, and has provided a precedent for the emergence of public involvement in research conducted since the early 1990s. Such involvement is now widely seen in breast cancer research, due to the large public concern and major social movement activity. This article reviews current practices and general models of public involvement in research and constructs a prototype. The authors interviewed researchers, program officers, and laypeople in order to understand the obstacles, processes, and benefits. They conclude that public involvement has major ramifications for the democratization of science and the construction of knowledge by teaching lay people about science and sensitizing researchers to concerns of the public. There is growing support on the part of scientists and government agents for public involvement.

  2. From research to practice: one organisational model for promoting research based practice.

    Science.gov (United States)

    Kitson, A

    1997-01-01

    This paper describes a framework used by the National Institute for Nursing in Oxford to integrate research, development and practice. With the increasing attention given to the topic of how research findings are implemented into clinical practice, it was felt important to share the challenges that have arisen in attempting to combine traditional research activities with more practice based development work. The emerging conceptual framework, structures and functions are described highlighting the variety of partnerships to be established in order to achieve the goal of integrating research into practice. While the underpinning principles of the framework--generating knowledge, implementing research into practice and evaluating the effectiveness of programmes--are not new, it is the way they have been combined within an organisational structure that could be helpful to others considering such a strategy. Both the strengths and weaknesses of the model are discussed, a number of conclusions drawn as to its robustness and consideration given to its replication.

  3. Research on Business Models in their Life Cycle

    Directory of Open Access Journals (Sweden)

    Adam Jabłoński

    2016-04-01

    Full Text Available The paper presents the results of theoretical discussions and research findings in the field of designing sustainable business models that support the creation of value at various stages of the business life cycle. The paper presents selected findings of extensive research into the business models of Polish companies listed on the Warsaw Stock Exchange. Companies which are at various stages of development should build and adapt their business models in order to maintain the ability to create value for stakeholders. Characteristics of business models at the early stages of development are different than at mature stages. The paper highlights the differences in business models in the context of the life cycle of companies and sustainability criteria. The paper presents research findings which show that the company’s development can be seen from the point of view of the business model. Research on business models concentrated on identifying the key attributes and the configuration of the business models appropriate for the early stage of development as well as the maturity stage. It was found that the business models of companies at an early stage of the development of companies listed on the Warsaw Stock Exchange are oriented primarily to how the company shapes, delivers, and captures value from the market in order to generate profits for shareholders and increase the value of the company, while the business models of mature companies include the intentions of management used to balance objectives with respect to different groups of stakeholders, and to carefully formulate and implement business objectives with particular attention paid to preserving the sustainability of the business. The assessment of business models from the point of view of the life cycle proves that managers change their approach to configuring business models over time; at some point, they include management intentions aimed at a broader range of goals than merely

  4. Theory, Modeling and Simulation: Research progress report 1994--1995

    Energy Technology Data Exchange (ETDEWEB)

    Garrett, B.C.; Dixon, D.A.; Dunning, T.H.

    1997-01-01

    The Pacific Northwest National Laboratory (PNNL) has established the Environmental Molecular Sciences Laboratory (EMSL). In April 1994, construction began on the new EMSL, a collaborative research facility devoted to advancing the understanding of environmental molecular science. Research in the Theory, Modeling, and Simulation (TM and S) program will play a critical role in understanding molecular processes important in restoring DOE`s research, development, and production sites, including understanding the migration and reactions of contaminants in soils and ground water, developing processes for isolation and processing of pollutants, developing improved materials for waste storage, understanding the enzymatic reactions involved in the biodegradation of contaminants, and understanding the interaction of hazardous chemicals with living organisms. The research objectives of the TM and S program are fivefold: to apply available electronic structure and dynamics techniques to study fundamental molecular processes involved in the chemistry of natural and contaminated systems; to extend current electronic structure and dynamics techniques to treat molecular systems of future importance and to develop new techniques for addressing problems that are computationally intractable at present; to apply available molecular modeling techniques to simulate molecular processes occurring in the multi-species, multi-phase systems characteristic of natural and polluted environments; to extend current molecular modeling techniques to treat ever more complex molecular systems and to improve the reliability and accuracy of such simulations; and to develop technologies for advanced parallel architectural computer systems. Research highlights of 82 projects are given.

  5. Can Psychological Expectation Models Be Adapted for Placebo Research?

    Science.gov (United States)

    Rief, Winfried; Petrie, Keith J

    2016-01-01

    Placebo responses contribute substantially to the effect and clinical outcome of medical treatments. Patients' expectations have been identified as one of the major mechanisms contributing to placebo effects. However, to date a general theoretical framework to better understand how patient expectations interact with features of medical treatment has not been developed. In this paper we outline an expectation model that can be used as framework for experimental studies on both placebo and nocebo mechanisms. This model is based on psychological concepts of expectation development, expectation maintenance, and expectation change within the typical paradigms used in placebo research. This theoretical framework reflects the dynamic aspects of the interaction between expectations and medical treatment, and offers a platform to combine psychological and neurophysiological research activities. Moreover, this model can be used to identify important future research questions. For example, we argue that the dynamic processes of expectation maintenance vs. expectation changes are not sufficiently addressed in current research on placebo mechanisms. Therefore, the question about how to change and optimize patients' expectations prior to treatment should be a special focus of future clinical research.

  6. Ethical issues in engineering models: an operations researcher's reflections.

    Science.gov (United States)

    Kleijnen, J

    2011-09-01

    This article starts with an overview of the author's personal involvement--as an Operations Research consultant--in several engineering case-studies that may raise ethical questions; e.g., case-studies on nuclear waste, water management, sustainable ecology, military tactics, and animal welfare. All these case studies employ computer simulation models. In general, models are meant to solve practical problems, which may have ethical implications for the various stakeholders; namely, the modelers, the clients, and the public at large. The article further presents an overview of codes of ethics in a variety of disciples. It discusses the role of mathematical models, focusing on the validation of these models' assumptions. Documentation of these model assumptions needs special attention. Some ethical norms and values may be quantified through the model's multiple performance measures, which might be optimized. The uncertainty about the validity of the model leads to risk or uncertainty analysis and to a search for robust models. Ethical questions may be pressing in military models, including war games. However, computer games and the related experimental economics may also provide a special tool to study ethical issues. Finally, the article briefly discusses whistleblowing. Its many references to publications and websites enable further study of ethical issues in modeling.

  7. Amphibians as animal models for laboratory research in physiology.

    Science.gov (United States)

    Burggren, Warren W; Warburton, Stephen

    2007-01-01

    The concept of animal models is well honored, and amphibians have played a prominent part in the success of using key species to discover new information about all animals. As animal models, amphibians offer several advantages that include a well-understood basic physiology, a taxonomic diversity well suited to comparative studies, tolerance to temperature and oxygen variation, and a greater similarity to humans than many other currently popular animal models. Amphibians now account for approximately 1/4 to 1/3 of lower vertebrate and invertebrate research, and this proportion is especially true in physiological research, as evident from the high profile of amphibians as animal models in Nobel Prize research. Currently, amphibians play prominent roles in research in the physiology of musculoskeletal, cardiovascular, renal, respiratory, reproductive, and sensory systems. Amphibians are also used extensively in physiological studies aimed at generating new insights in evolutionary biology, especially in the investigation of the evolution of air breathing and terrestriality. Environmental physiology also utilizes amphibians, ranging from studies of cryoprotectants for tissue preservation to physiological reactions to hypergravity and space exploration. Amphibians are also playing a key role in studies of environmental endocrine disruptors that are having disproportionately large effects on amphibian populations and where specific species can serve as sentinel species for environmental pollution. Finally, amphibian genera such as Xenopus, a genus relatively well understood metabolically and physiologically, will continue to contribute increasingly in this new era of systems biology and "X-omics."

  8. An Overview of Mesoscale Modeling Software for Energetic Materials Research

    Science.gov (United States)

    2010-03-01

    RESearch on Soft Matter ....................11 2.6.1 Underlying Algorithms...Mesocale modeling software summary. Software Algorithms Applications/Properties MesoDyn Dynamic Density Field Soft matter , polymers, melts, blends...equations. Table 2. MesoDyn summary. Company/Institution Accelrys Applications 1. Soft matter , complex fluids, polymer melts and blends, surfactants

  9. Treatment of Sexual Offenders: Research, Best Practices, and Emerging Models

    Science.gov (United States)

    Yates, Pamela M.

    2013-01-01

    Treatment of sexual offenders has evolved substantially over the years; various theoretical and practice models of treatment been developed, modified, refined, and proposed over time. The predominant current recommended approach, supported by research, adheres to specific principles of effective correctional intervention, follows a…

  10. Research on Model of Student Engagement in Online Learning

    Science.gov (United States)

    Peng, Wang

    2017-01-01

    In this study, online learning refers students under the guidance of teachers through the online learning platform for organized learning. Based on the analysis of related research results, considering the existing problems, the main contents of this paper include the following aspects: (1) Analyze and study the current student engagement model.…

  11. Quantitative Research: A Dispute Resolution Model for FTC Advertising Regulation.

    Science.gov (United States)

    Richards, Jef I.; Preston, Ivan L.

    Noting the lack of a dispute mechanism for determining whether an advertising practice is truly deceptive without generating the costs and negative publicity produced by traditional Federal Trade Commission (FTC) procedures, this paper proposes a model based upon early termination of the issues through jointly commissioned behavioral research. The…

  12. Developing a Model for Continuous Professional Development by Action Research

    Science.gov (United States)

    Herbert, Susan; Rainford, Marcia

    2014-01-01

    This paper presents a case study of the work of two teacher educators with an in-service science teacher. This case study forms one cycle of a larger action research study that will eventually lead to a model of how the third-space concept for teacher professional development can be realized in natural school settings. The case study took place in…

  13. Business model innovation: Past research, current debates, and future directions

    DEFF Research Database (Denmark)

    Hossain, Mokter

    2017-01-01

    Purpose – The purpose of this paper is to provide state-of-the-art knowledge about business model innovation (BMI) and suggest avenues for future research. Design/methodology/approach – A systematic literature review approach was adopted with thematic analysis being conducted on 92 articles...

  14. Multilevel Modeling: Overview and Applications to Research in Counseling Psychology

    Science.gov (United States)

    Kahn, Jeffrey H.

    2011-01-01

    Multilevel modeling (MLM) is rapidly becoming the standard method of analyzing nested data, for example, data from students within multiple schools, data on multiple clients seen by a smaller number of therapists, and even longitudinal data. Although MLM analyses are likely to increase in frequency in counseling psychology research, many readers…

  15. Multilevel Modeling: Overview and Applications to Research in Counseling Psychology

    Science.gov (United States)

    Kahn, Jeffrey H.

    2011-01-01

    Multilevel modeling (MLM) is rapidly becoming the standard method of analyzing nested data, for example, data from students within multiple schools, data on multiple clients seen by a smaller number of therapists, and even longitudinal data. Although MLM analyses are likely to increase in frequency in counseling psychology research, many readers…

  16. Study and Research Courses as an Epistemological Model for Didactics

    Science.gov (United States)

    Winslow, Carl; Matheron, Yves; Mercier, Alain

    2013-01-01

    The aim of this paper is explain how the notion of "study and research course", a recent construct in the anthropological theory of didactics, provides a general tool to model mathematical knowledge from a didactical perspective. We do this from two points of view. First, the notion itself arose as a tool for didactic design, particularly in…

  17. Swales' Cars Model and the Metaphor of Research Space: An ...

    African Journals Online (AJOL)

    ANDCORPgh changing the world

    following academics for reading through drafts of the paper and offering valuable ... The CARS (Create a Research Space) model for writing academic introductions ..... metaphysical and sometimes mystical or psychological experience of the poet, .... 'COVERT' STEP 3: [A lot has been written about the traditional music of.

  18. Fedora Content Modelling for Improved Services for Research Databases

    DEFF Research Database (Denmark)

    Elbæk, Mikael Karstensen; Heller, Alfred; Pedersen, Gert Schmeltz

    A re-implementation of the research database of the Technical University of Denmark, DTU, is based on Fedora. The backbone consists of content models for primary and secondary entities and their relationships, giving flexible and powerful extraction capabilities for interoperability and reporting...

  19. Structuring research methods and data with the research object model: genomics workflows as a case study.

    Science.gov (United States)

    Hettne, Kristina M; Dharuri, Harish; Zhao, Jun; Wolstencroft, Katherine; Belhajjame, Khalid; Soiland-Reyes, Stian; Mina, Eleni; Thompson, Mark; Cruickshank, Don; Verdes-Montenegro, Lourdes; Garrido, Julian; de Roure, David; Corcho, Oscar; Klyne, Graham; van Schouwen, Reinout; 't Hoen, Peter A C; Bechhofer, Sean; Goble, Carole; Roos, Marco

    2014-01-01

    One of the main challenges for biomedical research lies in the computer-assisted integrative study of large and increasingly complex combinations of data in order to understand molecular mechanisms. The preservation of the materials and methods of such computational experiments with clear annotations is essential for understanding an experiment, and this is increasingly recognized in the bioinformatics community. Our assumption is that offering means of digital, structured aggregation and annotation of the objects of an experiment will provide necessary meta-data for a scientist to understand and recreate the results of an experiment. To support this we explored a model for the semantic description of a workflow-centric Research Object (RO), where an RO is defined as a resource that aggregates other resources, e.g., datasets, software, spreadsheets, text, etc. We applied this model to a case study where we analysed human metabolite variation by workflows. We present the application of the workflow-centric RO model for our bioinformatics case study. Three workflows were produced following recently defined Best Practices for workflow design. By modelling the experiment as an RO, we were able to automatically query the experiment and answer questions such as "which particular data was input to a particular workflow to test a particular hypothesis?", and "which particular conclusions were drawn from a particular workflow?". Applying a workflow-centric RO model to aggregate and annotate the resources used in a bioinformatics experiment, allowed us to retrieve the conclusions of the experiment in the context of the driving hypothesis, the executed workflows and their input data. The RO model is an extendable reference model that can be used by other systems as well. The Research Object is available at http://www.myexperiment.org/packs/428 The Wf4Ever Research Object Model is available at http://wf4ever.github.io/ro.

  20. Validation of the Osteopenia Sheep Model for Orthopaedic Biomaterial Research

    DEFF Research Database (Denmark)

    Ding, Ming; Danielsen, C.C.; Cheng, L.

    2009-01-01

    Validation of the Osteopenia Sheep Model for Orthopaedic Biomaterial Research +1Ding, M; 2Danielsen, CC; 1Cheng, L; 3Bollen, P; 4Schwarz, P; 1Overgaard, S +1Dept of Orthopaedics O, Odense University Hospital, Denmark, 2Dept of Connective Tissue Biology, University of Aarhus, Denmark, 3Biomedicine...... Lab, University of Southern Denmark, 4Dept of Geriatrics, Glostrup University Hospital, Denmark ming.ding@ouh.regionsyddanmark.dk   Introduction:  Currently, majority orthopaedic prosthesis and biomaterial researches have been based on investigation in normal animals. In most clinical situations, most...... resemble osteoporosis in humans. This study aimed to validate glucocorticoid-induced osteopenia sheep model for orthopaedic implant and biomaterial research. We hypothesized that a 7-month GC treatment together with restricted diet but without OVX would induce osteopenia. Materials and Methods: Eighteen...

  1. The vaccination model in psychoneuroimmunology research: a review.

    Science.gov (United States)

    Phillips, Anna C

    2012-01-01

    This chapter explores the reasoning behind using the vaccination model to examine the influence of psychosocial factors on immunity. It then briefly discusses the mechanics of the vaccination response and the protocols used in Psychoneuroimmunology vaccine research, before giving examples from the research literature of the studies examining relationships such as the association between stress and the vaccination response. It also explores the ways the vaccination model can be used to answer key questions in Psychoneuroimmunology, such as: "does it matter when stressful life events occur relative to when the vaccine is received?" "what are the effects of prior exposure to the antigen?" and "do other psychosocial factors influence vaccine response besides stress?" Finally, it briefly considers the mechanisms underlying psychosocial factors and vaccination response associations and the future research needed to understand these better, and indeed to use current and future knowledge to improve and enhance vaccine responses in key at risk populations.

  2. Rodent models in Down syndrome research: impact and future opportunities.

    Science.gov (United States)

    Herault, Yann; Delabar, Jean M; Fisher, Elizabeth M C; Tybulewicz, Victor L J; Yu, Eugene; Brault, Veronique

    2017-10-01

    Down syndrome is caused by trisomy of chromosome 21. To date, a multiplicity of mouse models with Down-syndrome-related features has been developed to understand this complex human chromosomal disorder. These mouse models have been important for determining genotype-phenotype relationships and identification of dosage-sensitive genes involved in the pathophysiology of the condition, and in exploring the impact of the additional chromosome on the whole genome. Mouse models of Down syndrome have also been used to test therapeutic strategies. Here, we provide an overview of research in the last 15 years dedicated to the development and application of rodent models for Down syndrome. We also speculate on possible and probable future directions of research in this fast-moving field. As our understanding of the syndrome improves and genome engineering technologies evolve, it is necessary to coordinate efforts to make all Down syndrome models available to the community, to test therapeutics in models that replicate the whole trisomy and design new animal models to promote further discovery of potential therapeutic targets. © 2017. Published by The Company of Biologists Ltd.

  3. Research on reality map colour design computer model

    Institute of Scientific and Technical Information of China (English)

    刘书楼; 陈宝雯; 刘天舒; 施祖辉; 卢峰; 韩培军; 刘冰

    1995-01-01

    Through the crucial techniques and technical difficulties of the research on reality map colour design computer model (RMCDCM), based on the principle of chromatics and the experimental analysis, a new model about the transformation between CMY ink printing and RGB screen colours and RMCDCM is set up In the chromatics, there is a general concept that the range of RGB screen colours is larger than that of printing colours. The concept is exactly explained. It not only accounts for the erroneous phenomena from the theory which are produced when CRT monitor, PAL and NTSC models reproduce printing colour standards, but also solves the technical problems from the methodology which long exist in the research for screen reproduction and printing restoration of printing colour standards. A theoretical basis is provided.

  4. Peer-Mentored Research Development Meeting: A Model for Successful Peer Mentoring among Junior Level Researchers

    Science.gov (United States)

    Santucci, Aimee K.; Lingler, Jennifer H.; Schmidt, Karen L.; Nolan, Beth A. D.; Thatcher, Dawn; Polk, Deborah E.

    2008-01-01

    Objective: This report describes a model for the development, process, and tracking methods of a Peer-mentored Research Development Meeting (PRDM), an interdisciplinary peer mentoring program. The program was initiated in 2004 by a group of postdoctoral scholars and junior faculty from the Schools of the Health Sciences at the University of…

  5. Shared Ageing Research Models (ShARM) : a new facility to support ageing research

    NARCIS (Netherlands)

    Duran, Adele L.; Potter, Paul; Wells, Sara; Kirkwood, Tom; von Zglinicki, Thomas; McArdle, Anne; Scudamore, Cheryl; Meng, Qing-Jun; de Haan, Gerald; Corcoran, Anne; Bellantuono, Ilaria

    2013-01-01

    In order to manage the rise in life expectancy and the concomitant increased occurrence of age-related diseases, research into ageing has become a strategic priority. Mouse models are commonly utilised as they share high homology with humans and show many similar signs and diseases of ageing.

  6. Models in geography ? A sense to research

    Directory of Open Access Journals (Sweden)

    Roger Brunet

    2001-12-01

    Full Text Available Ideas on models and modelling made a conspicuous entry into geography in the 1960s. They have since evolved, through practice and under the influence of—partly justified—criticism. No serious research can dispense with modelling as a means to reach the essential and to evaluate the divergence between singular geographical objects and the models that assist their interpretation. On two conditions, which merit further definition and exploration : models must have meaning in and through the practices, objectives and intentions of human action ; and we must know how to use models—whether tried and tested or new—to understand the structure and dynamics of singular geographical objects, and not just to infer general mechanisms from them, even though they will certainly enhance our understanding of the nature and scope of general mechanisms.

  7. Modeling and Analysis of Multidiscipline Research Teams at NASA Langley Research Center: A Systems Thinking Approach

    Science.gov (United States)

    Waszak, Martin R.; Barthelemy, Jean-Francois; Jones, Kenneth M.; Silcox, Richard J.; Silva, Walter A.; Nowaczyk, Ronald H.

    1998-01-01

    Multidisciplinary analysis and design is inherently a team activity due to the variety of required expertise and knowledge. As a team activity, multidisciplinary research cannot escape the issues that affect all teams. The level of technical diversity required to perform multidisciplinary analysis and design makes the teaming aspects even more important. A study was conducted at the NASA Langley Research Center to develop a model of multidiscipline teams that can be used to help understand their dynamics and identify key factors that influence their effectiveness. The study sought to apply the elements of systems thinking to better understand the factors, both generic and Langley-specific, that influence the effectiveness of multidiscipline teams. The model of multidiscipline research teams developed during this study has been valuable in identifying means to enhance team effectiveness, recognize and avoid problem behaviors, and provide guidance for forming and coordinating multidiscipline teams.

  8. Shared Ageing Research Models (ShARM): a new facility to support ageing research.

    Science.gov (United States)

    Duran, Adele L; Potter, Paul; Wells, Sara; Kirkwood, Tom; von Zglinicki, Thomas; McArdle, Anne; Scudamore, Cheryl; Meng, Qing-Jun; de Haan, Gerald; Corcoran, Anne; Bellantuono, Ilaria

    2013-12-01

    In order to manage the rise in life expectancy and the concomitant increased occurrence of age-related diseases, research into ageing has become a strategic priority. Mouse models are commonly utilised as they share high homology with humans and show many similar signs and diseases of ageing. However, the time and cost needed to rear aged cohorts can limit research opportunities. Sharing of resources can provide an ethically and economically superior framework to overcome some of these issues but requires dedicated infrastructure. Shared Ageing Research Models (ShARM) ( www.ShARMUK.org ) is a new, not-for-profit organisation funded by Wellcome Trust, open to all investigators. It collects, stores and distributes flash frozen tissues from aged murine models through its biorepository and provides a database of live ageing mouse colonies available in the UK and abroad. It also has an online environment (MICEspace) for collation and analysis of data from communal models and discussion boards on subjects such as the welfare of ageing animals and common endpoints for intervention studies. Since launching in July 2012, thanks to the generosity of researchers in UK and Europe, ShARM has collected more than 2,500 tissues and has in excess of 2,000 mice registered in live ageing colonies. By providing the appropriate support, ShARM has been able to bring together the knowledge and experience of investigators in the UK and Europe to maximise research outputs with little additional cost and minimising animal use in order to facilitate progress in ageing research.

  9. Supply chain management models, applications, and research directions

    CERN Document Server

    Pardalos, Panos; Romeijn, H

    2005-01-01

    This work brings together some of the most up to date research in the application of operations research and mathematical modeling te- niques to problems arising in supply chain management and e-Commerce. While research in the broad area of supply chain management enc- passes a wide range of topics and methodologies, we believe this book provides a good snapshot of current quantitative modeling approaches, issues, and trends within the field. Each chapter is a self-contained study of a timely and relevant research problem in supply chain mana- ment. The individual works place a heavy emphasis on the application of modeling techniques to real world management problems. In many instances, the actual results from applying these techniques in practice are highlighted. In addition, each chapter provides important mana- rial insights that apply to general supply chain management practice. The book is divided into three parts. The first part contains ch- ters that address the new and rapidly growing role of the inte...

  10. The miniature pig as an animal model in biomedical research.

    Science.gov (United States)

    Vodicka, Petr; Smetana, Karel; Dvoránková, Barbora; Emerick, Teresa; Xu, Yingzhi Z; Ourednik, Jitka; Ourednik, Václav; Motlík, Jan

    2005-05-01

    Crucial prerequisites for the development of safe preclinical protocols in biomedical research are suitable animal models that would allow for human-related validation of valuable research information gathered from experimentation with lower mammals. In this sense, the miniature pig, sharing many physiological similarities with humans, offers several breeding and handling advantages (when compared to non-human primates), making it an optimal species for preclinical experimentation. The present review offers several examples taken from current research in the hope of convincing the reader that the porcine animal model has gained massively in importance in biomedical research during the last few years. The adduced examples are taken from the following fields of investigation: (a) the physiology of reproduction, where pig oocytes are being used to study chromosomal abnormalities (aneuploidy) in the adult human oocyte; (b) the generation of suitable organs for xenotransplantation using transgene expression in pig tissues; (c) the skin physiology and the treatment of skin defects using cell therapy-based approaches that take advantage of similarities between pig and human epidermis; and (d) neurotransplantation using porcine neural stem cells grafted into inbred miniature pigs as an alternative model to non-human primates xenografted with human cells.

  11. A research and evaluation capacity building model in Western Australia.

    Science.gov (United States)

    Lobo, Roanna; Crawford, Gemma; Hallett, Jonathan; Laing, Sue; Mak, Donna B; Jancey, Jonine; Rowell, Sally; McCausland, Kahlia; Bastian, Lisa; Sorenson, Anne; Tilley, P J Matt; Yam, Simon; Comfort, Jude; Brennan, Sean; Doherty, Maryanne

    2016-12-27

    Evaluation of public health programs, services and policies is increasingly required to demonstrate effectiveness. Funding constraints necessitate that existing programs, services and policies be evaluated and their findings disseminated. Evidence-informed practice and policy is also desirable to maximise investments in public health. Partnerships between public health researchers, service providers and policymakers can help address evaluation knowledge and skills gaps. The Western Australian Sexual Health and Blood-borne Virus Applied Research and Evaluation Network (SiREN) aims to build research and evaluation capacity in the sexual health and blood-borne virus sector in Western Australia (WA). Partners' perspectives of the SiREN model after 2 years were explored. Qualitative written responses from service providers, policymakers and researchers about the SiREN model were analysed thematically. Service providers reported that participation in SiREN prompted them to consider evaluation earlier in the planning process and increased their appreciation of the value of evaluation. Policymakers noted benefits of the model in generating local evidence and highlighting local issues of importance for consideration at a national level. Researchers identified challenges communicating the services available through SiREN and the time investment needed to develop effective collaborative partnerships. Stronger engagement between public health researchers, service providers and policymakers through collaborative partnerships has the potential to improve evidence generation and evidence translation. These outcomes require long-term funding and commitment from all partners to develop and maintain partnerships. Ongoing monitoring and evaluation can ensure the partnership remains responsive to the needs of key stakeholders. The findings are applicable to many sectors.

  12. Tissue-engineered models of human tumors for cancer research

    Science.gov (United States)

    Villasante, Aranzazu; Vunjak-Novakovic, Gordana

    2015-01-01

    Introduction Drug toxicity often goes undetected until clinical trials, which are the most costly and dangerous phase of drug development. Both the cultures of human cells and animal studies have limitations that cannot be overcome by incremental improvements in drug-testing protocols. A new generation of bioengineered tumors is now emerging in response to these limitations, with potential to transform drug screening by providing predictive models of tumors within their tissue context, for studies of drug safety and efficacy. An area that could greatly benefit from these models is cancer research. Areas covered In this review, the authors first describe the engineered tumor systems, using Ewing's sarcoma as an example of human tumor that cannot be predictably studied in cell culture and animal models. Then, they discuss the importance of the tissue context for cancer progression and outline the biomimetic principles for engineering human tumors. Finally, they discuss the utility of bioengineered tumor models for cancer research and address the challenges in modeling human tumors for use in drug discovery and testing. Expert opinion While tissue models are just emerging as a new tool for cancer drug discovery, they are already demonstrating potential for recapitulating, in vitro, the native behavior of human tumors. Still, numerous challenges need to be addressed before we can have platforms with a predictive power appropriate for the pharmaceutical industry. Some of the key needs include the incorporation of the vascular compartment, immune system components, and mechanical signals that regulate tumor development and function. PMID:25662589

  13. Integrated modelling of ecosystem services and energy systems research

    Science.gov (United States)

    Agarwala, Matthew; Lovett, Andrew; Bateman, Ian; Day, Brett; Agnolucci, Paolo; Ziv, Guy

    2016-04-01

    The UK Government is formally committed to reducing carbon emissions and protecting and improving natural capital and the environment. However, actually delivering on these objectives requires an integrated approach to addressing two parallel challenges: de-carbonising future energy system pathways; and safeguarding natural capital to ensure the continued flow of ecosystem services. Although both emphasise benefiting from natural resources, efforts to connect natural capital and energy systems research have been limited, meaning opportunities to improve management of natural resources and meet society's energy needs could be missed. The ecosystem services paradigm provides a consistent conceptual framework that applies in multiple disciplines across the natural and economic sciences, and facilitates collaboration between them. At the forefront of the field, integrated ecosystem service - economy models have guided public- and private-sector decision making at all levels. Models vary in sophistication from simple spreadsheet tools to complex software packages integrating biophysical, GIS and economic models and draw upon many fields, including ecology, hydrology, geography, systems theory, economics and the social sciences. They also differ in their ability to value changes in natural capital and ecosystem services at various spatial and temporal scales. Despite these differences, current models share a common feature: their treatment of energy systems is superficial at best. In contrast, energy systems research has no widely adopted, unifying conceptual framework that organises thinking about key system components and interactions. Instead, the literature is organised around modelling approaches, including life cycle analyses, econometric investigations, linear programming and computable general equilibrium models. However, some consistencies do emerge. First, often contain a linear set of steps, from exploration to resource supply, fuel processing, conversion

  14. Psychometric model for safety culture assessment in nuclear research facilities

    Energy Technology Data Exchange (ETDEWEB)

    Nascimento, C.S. do, E-mail: claudio.souza@ctmsp.mar.mil.br [Centro Tecnológico da Marinha em São Paulo (CTMSP), Av. Professor Lineu Prestes 2468, 05508-000 São Paulo, SP (Brazil); Andrade, D.A., E-mail: delvonei@ipen.br [Instituto de Pesquisas Energéticas e Nucleares (IPEN/CNEN – SP), Av. Professor Lineu Prestes 2242, 05508-000 São Paulo, SP (Brazil); Mesquita, R.N. de, E-mail: rnavarro@ipen.br [Instituto de Pesquisas Energéticas e Nucleares (IPEN/CNEN – SP), Av. Professor Lineu Prestes 2242, 05508-000 São Paulo, SP (Brazil)

    2017-04-01

    Highlights: • A psychometric model to evaluate ‘safety climate’ at nuclear research facilities. • The model presented evidences of good psychometric qualities. • The model was applied to nuclear research facilities in Brazil. • Some ‘safety culture’ weaknesses were detected in the assessed organization. • A potential tool to develop safety management programs in nuclear facilities. - Abstract: A safe and reliable operation of nuclear power plants depends not only on technical performance, but also on the people and on the organization. Organizational factors have been recognized as the main causal mechanisms of accidents by research organizations through USA, Europe and Japan. Deficiencies related with these factors reveal weaknesses in the organization’s safety culture. A significant number of instruments to assess the safety culture based on psychometric models that evaluate safety climate through questionnaires, and which are based on reliability and validity evidences, have been published in health and ‘safety at work’ areas. However, there are few safety culture assessment instruments with these characteristics (reliability and validity) available on nuclear literature. Therefore, this work proposes an instrument to evaluate, with valid and reliable measures, the safety climate of nuclear research facilities. The instrument was developed based on methodological principles applied to research modeling and its psychometric properties were evaluated by a reliability analysis and validation of content, face and construct. The instrument was applied to an important nuclear research organization in Brazil. This organization comprises 4 research reactors and many nuclear laboratories. The survey results made possible a demographic characterization and the identification of some possible safety culture weaknesses and pointing out potential areas to be improved in the assessed organization. Good evidence of reliability with Cronbach's alpha

  15. THE TSUNAMI ASSESSMENT MODELLING SYSTEM BY THE JOINT RESEARCH CENTRE

    Directory of Open Access Journals (Sweden)

    Alessandro Annunziato

    2007-01-01

    Full Text Available The Tsunami Assessment Modeling System was developed by the European Commission, Joint Research Centre, in order to serve Tsunami early warning systems such as the Global Disaster Alerts and Coordination System (GDACS in the evaluation of possible consequences by a Tsunami of seismic nature. The Tsunami Assessment Modeling System is currently operational and is calculating in real time all the events occurring in the world, calculating the expected Tsunami wave height and identifying the locations where the wave height should be too high. The first part of the paper describes the structure of the system, the underlying analytical models and the informatics arrangement; the second part shows the activation of the system and the results of the calculated analyses. The final part shows future development of this modeling tool.

  16. MODEL RESEARCH OF THE ACIVE VIBROIZOLATION CABS MACHINE

    Directory of Open Access Journals (Sweden)

    Jerzy MARGIELEWICZ

    2014-03-01

    Full Text Available The study was carried out computer simulations of mechatronic model bridge crane, which is intended to theoretical evaluation of the possibility of eliminating the mechanical vibrations affecting the operator's cab driven machine. The model studies used fixed value control, the controlled variable is selected as the vertical displacement of the cab. Also included in the research model rheological model of the operator's body. We examined four overhead cranes with lifting capacity of 50T, which are classified in accordance with the directive of the European Union concerning the design of cranes, the four classes of cranes HC stiffness. The use of an active vibration isolation system in which distinguishes two negative feedback loops, very well eliminate mechanical vibration to the operator.

  17. Research advances in animal models of nonalcoholic fatty liver disease

    Directory of Open Access Journals (Sweden)

    HUANG Haiyan

    2014-09-01

    Full Text Available In recent years, the incidence of nonalcoholic fatty liver disease (NAFLD has increased gradually along with the rising prevalence of obesity, type 2 diabetes, and hyperlipidemia, and NAFLD has become one of the most common chronic liver diseases in the world and the second major liver disease after chronic viral hepatitis in China. However, its pathogenesis has not yet been clarified. Animal models are playing an important role in researches on NAFLD due to the facts that the development and progression of NAFLD require a long period of time, and ethical limitations exist in conducting drug trials in patients or collecting liver tissues from patients. The animal models with histopathology similar to that of NAFLD patients are reviewed, and their modeling principle, as well as the advantages and disadvantages, are compared. Animal models provide a powerful tool for further studies of NAFLD pathogenesis and drug screening for prevention and treatment of NAFLD.

  18. Modelling the Image Research of a Tourism Destination

    Directory of Open Access Journals (Sweden)

    Nicolae Teodorescu

    2014-11-01

    Full Text Available The problematic area of the tourism destination image has a high expansion in marketing, the efforts of its conceptualization and phenomenalism being remarkable among specialists. In this context, the authors propose a systemic approach, the result of which refers to a model regarding the image research of a tourism destination, whose validation has been attained using Transalpina destination. The model created by the authors envisages morphological features and specific functional relationships, which are consistent with the marketing theory, and, in context, with the consumer behaviour theory. The conceptualmethodological solutions are magnified by applicative-experimental validations, which enhance the theoretical and practical valences of the created model. The main direction of developing the elaborated model consists in efforts of formalization and abstracting, in the perspective offered by several scientific disciplines.

  19. Complexity and agent-based modelling in urban research

    DEFF Research Database (Denmark)

    Fertner, Christian

    Urbanisation processes are results of a broad variety of actors or actor groups and their behaviour and decisions based on different experiences, knowledge, resources, values etc. The decisions done are often on a micro/individual level but resulting in macro/collective behaviour. In urban research...... influence on the bigger system. Traditional scientific methods or theories often tried to simplify, not accounting complex relations of actors and decision-making. The introduction of computers in simulation made new approaches in modelling, as for example agent-based modelling (ABM), possible, dealing...

  20. Sensitivity-based research prioritization through stochastic characterization modeling

    DEFF Research Database (Denmark)

    Wender, Ben A.; Prado-Lopez, Valentina; Fantke, Peter

    2017-01-01

    Product developers using life cycle toxicity characterization models to understand the potential impacts of chemical emissions face serious challenges related to large data demands and high input data uncertainty. This motivates greater focus on model sensitivity toward input parameter variability...... to guide research efforts in data refinement and design of experiments for existing and emerging chemicals alike. This study presents a sensitivity-based approach for estimating toxicity characterization factors given high input data uncertainty and using the results to prioritize data collection according...

  1. Zebrafish: an animal model for research in veterinary medicine.

    Science.gov (United States)

    Nowik, N; Podlasz, P; Jakimiuk, A; Kasica, N; Sienkiewicz, W; Kaleczyc, J

    2015-01-01

    The zebrafish (Danio rerio) has become known as an excellent model organism for studies of vertebrate biology, vertebrate genetics, embryonal development, diseases and drug screening. Nevertheless, there is still lack of detailed reports about usage of the zebrafish as a model in veterinary medicine. Comparing to other vertebrates, they can lay hundreds of eggs at weekly intervals, externally fertilized zebrafish embryos are accessible to observation and manipulation at all stages of their development, which makes possible to simplify the research techniques such as fate mapping, fluorescent tracer time-lapse lineage analysis and single cell transplantation. Although zebrafish are only 2.5 cm long, they are easy to maintain. Intraperitoneal and intracerebroventricular injections, blood sampling and measurement of food intake are possible to be carry out in adult zebrafish. Danio rerio is a useful animal model for neurobiology, developmental biology, drug research, virology, microbiology and genetics. A lot of diseases, for which the zebrafish is a perfect model organism, affect aquatic animals. For a part of them, like those caused by Mycobacterium marinum or Pseudoloma neutrophila, Danio rerio is a natural host, but the zebrafish is also susceptible to the most of fish diseases including Itch, Spring viraemia of carp and Infectious spleen and kidney necrosis. The zebrafish is commonly used in research of bacterial virulence. The zebrafish embryo allows for rapid, non-invasive and real time analysis of bacterial infections in a vertebrate host. Plenty of common pathogens can be examined using zebrafish model: Streptococcus iniae, Vibrio anguillarum or Listeria monocytogenes. The steps are taken to use the zebrafish also in fungal research, especially that dealing with Candida albicans and Cryptococcus neoformans. Although, the zebrafish is used commonly as an animal model to study diseases caused by external agents, it is also useful in studies of metabolic

  2. Agent-based Modelling, a new kind of research

    DEFF Research Database (Denmark)

    Held, Fabian P.; Wilkinson, Ian F.; Marks, Robert E.;

    2014-01-01

    We discuss the use of Agent-based Modelling for the development and testing of theories about emergent social phenomena in marketing and the social sciences in general. We address both theoretical aspects about the types of phenomena that are suitably addressed with this approach and practical gu...... development. The main goal of this paper was to make research on complex social systems more accessible and help anticipate and structure the research process. © 2014 Australian and New Zealand Marketing Academy.......We discuss the use of Agent-based Modelling for the development and testing of theories about emergent social phenomena in marketing and the social sciences in general. We address both theoretical aspects about the types of phenomena that are suitably addressed with this approach and practical...

  3. A Lifecourse Model of Multimorbidity Resilience: Theoretical and Research Developments.

    Science.gov (United States)

    Wister, Andrew V; Coatta, Katherine L; Schuurman, Nadine; Lear, Scott A; Rosin, Miriam; MacKey, Dawn

    2016-04-01

    The purpose of this article is to advance a Lifecourse Model of Multimorbidity Resilience. It focuses on the ways in which individuals face adversities associated with multimorbidity and regain a sense of wellness through a complex, dynamic phenomenon termed resilience. A comprehensive review of 112 publications (between 1995 and 2015) was conducted using several comprehensive electronic data bases. Two independent researchers extracted and synthesized resilience literature with specific applications to chronic illness. The article outlines five stages of theoretical development of resilience, synthesizes these with the aging and chronic illness literature, builds a rationale for a lifecourse approach to resilience, and applies the model to multimorbidity. Cultivating and maintaining resilience is fundamental to functioning and quality of life for those with multimorbidity. We found that there are a number of gaps in both basic and applied research that need to be filled to advance knowledge and practice based on resilience approaches.

  4. Recruiting Transcultural Qualitative Research Participants: A Conceptual Model

    Directory of Open Access Journals (Sweden)

    Phyllis Eide

    2005-06-01

    Full Text Available Working with diverse populations poses many challenges to the qualitative researcher who is a member of the dominant culture. Traditional methods of recruitment and selection (such as flyers and advertisements are often unproductive, leading to missed contributions from potential participants who were not recruited and researcher frustration. In this article, the authors explore recruitment issues related to the concept of personal knowing based on experiences with Aboriginal Hawai'ian and Micronesian populations, wherein knowing and being known are crucial to successful recruitment of participants. They present a conceptual model that incorporates key concepts of knowing the other, cultural context, and trust to guide other qualitative transcultural researchers. They also describe challenges, implications, and concrete suggestions for recruitment of participants.

  5. Multilevel modeling: overview and applications to research in counseling psychology.

    Science.gov (United States)

    Kahn, Jeffrey H

    2011-04-01

    Multilevel modeling (MLM) is rapidly becoming the standard method of analyzing nested data, for example, data from students within multiple schools, data on multiple clients seen by a smaller number of therapists, and even longitudinal data. Although MLM analyses are likely to increase in frequency in counseling psychology research, many readers of counseling psychology journals have had only limited exposure to MLM concepts. This paper provides an overview of MLM that blends mathematical concepts with examples drawn from counseling psychology. This tutorial is intended to be a first step in learning about MLM; readers are referred to other sources for more advanced explorations of MLM. In addition to being a tutorial for understanding and perhaps even conducting MLM analyses, this paper reviews recent research in counseling psychology that has adopted a multilevel framework, and it provides ideas for MLM approaches to future research in counseling psychology.

  6. Efficacy of Female Rat Models in Translational Cardiovascular Aging Research

    Directory of Open Access Journals (Sweden)

    K. M. Rice

    2014-01-01

    Full Text Available Cardiovascular disease is the leading cause of death in women in the United States. Aging is a primary risk factor for the development of cardiovascular disease as well as cardiovascular-related morbidity and mortality. Aging is a universal process that all humans undergo; however, research in aging is limited by cost and time constraints. Therefore, most research in aging has been done in primates and rodents; however it is unknown how well the effects of aging in rat models translate into humans. To compound the complication of aging gender has also been indicated as a risk factor for various cardiovascular diseases. This review addresses the systemic pathophysiology of the cardiovascular system associated with aging and gender for aging research with regard to the applicability of rat derived data for translational application to human aging.

  7. From Mice to Men: research models of developmental programming

    OpenAIRE

    2013-01-01

    Developmental programming can be defined as a response to a specific challenge to the mammalian organism during a critical developmental time window that alters the trajectory of development with persistent effects on offspring phenotype and predisposition to future illness. We focus on the need for studies in relevant, well-characterized animal models in the context of recent research discoveries on the challenges, mechanisms and outcomes of developmental programming. We discuss commonalitie...

  8. Project management system model development and experimental research

    OpenAIRE

    Golubeva, Viktorija

    2006-01-01

    Project management is the application of knowledge, skills, tools and techniques to project activities to meet project requirements. Project Management Information System is tightly connected with organizational structure and particularity of executed projects. However the main objective of this research was to identify project management model that would be universal, helpful and easily used with small and medium projects In analysis phase we reviewed different methodologies, project ...

  9. Research on the Business English training model within MBA program

    OpenAIRE

    Natalia Yankovskaya; Olga Neklyudova

    2015-01-01

    The paper presents a brief summary of the research on the Business English training model within MBA program students. This study is devoted to the problem of developing a professional foreign language communicative competency of MBA program participants. A particular feature of additional MBA qualification is its international status which presupposes that its graduates (mid-level and top managers) should realize their professional tasks in a foreign language. The analysis of literary ...

  10. Earth system multi-body restriction dynamics model research

    Institute of Scientific and Technical Information of China (English)

    ZHANG; Qingxian; BI; Siwen; GONG; Huili

    2006-01-01

    Research provides a theoretical basis for an Earth system multi-body mechanics model and its dynamics, including the Earth system multi-body restriction function and its power, Earth system multi-body restriction under decreasing generalized velocity and decreasing partial palstance, the Earth system multi-body decreasing generalized force, a moving mechanics function, and the Earth system multi-body restriction's wattful and wattless forces.

  11. Standardisation of sheep model for endodontic regeneration/revitalisation research.

    Science.gov (United States)

    Altaii, Milad; Broberg, Marita; Cathro, Peter; Richards, Lindsay

    2016-05-01

    Different endodontic regeneration/revitalisation protocols have been suggested for the treatment of immature permanent teeth with pulp necrosis. Many aspects of these protocols require further investigating necessitating a suitable standardised animal model for research purposes. The focus of this study was to examine the anatomy and histology of sheep teeth at different stages of development to find an appropriate dental age for endodontic regeneration/revitalisation research. Sheep teeth at mature and immature dental ages were investigated. Standardized radiography, computed tomography, and histology were used to measure root length, apical-third dentine thickness and apex diameter, and to evaluate tissue development stages. A mature sheep tooth has an apical area which consists of a major foramen, intermediate dilatation and minor foramen. From the time of eruption to maturation no major changes occur in the incisor root lengths, but the apical foramen width decreases and the dentinal wall thickness increases. The two-tooth age exhibited the most similar features to that of an immature permanent human tooth. Sheep appears to be an appropriate animal model for endodontic regeneration/revitalization research with similar dimension and characteristics to human anterior teeth. Each dental age has its advantages and disadvantages. The two-tooth age showed the most favourable criteria making this age the most suitable for in vivo regeneration/revitalisation research. Copyright © 2016. Published by Elsevier Ltd.

  12. Eastern European Political Socialization Modeling Research: A Literature Review

    Directory of Open Access Journals (Sweden)

    Camelia Florela Voinea

    2014-01-01

    Full Text Available This paper presents empirical modeling research on political socialization of the citizens in the new Eastern European democracies. The political socialization issue offers a comparative perspective over the modeling methodologies in analytical paradigms. Eastern European political culture research has revealed features of the electoral behavior and political participation which can be identified in different degrees in all the new democracies in the area: passivity with respect to political activity of parties, elites and institutions, political apathy or lack of reaction to anti-democratic actions, skepticism or distrust in institutions, scarce participation to social movements. Several authors explain the actual political behavior of the Eastern European citizens’ and their low social and political involvement by the (political culture heritage of the communist regimes in which they lived for a long time, and which keeps shaping their political attitudes towards the state, civil society, government and institutions. Research issues in the analysis of political participation are traditionally based on statistics analyses of empirical evidence coming from public surveys. However, scarcity ofempirical data from the communist periode with regard to (political socialization, values and beliefs represent a major obstacle towards a better understanding of the historical roots of current behaviors and attitudes. Scarcity of observational data might be overcome by computational and simulation modeling.

  13. Research

    African Journals Online (AJOL)

    ebutamanya

    2015-03-02

    Mar 2, 2015 ... Shared and mutually beneficial resources within international research ... organizations[1-9]. ... facilitate research career paths, but few career models exist in Africa ..... international and local resources to clinical studies locally. The ability of ... investigators were seen as an important asset for the transfer of.

  14. MODEL ORGANISMS USED IN MOLECULAR BIOLOGY OR MEDICAL RESEARCH

    Directory of Open Access Journals (Sweden)

    Pandey Govind

    2011-11-01

    Full Text Available A model organism is a non-human species that is studied to understand specific biological phenomena with the expectation that investigations made in the organism model will provide insight into the workings of other organisms. The model organisms are widely used to explore potential causes and treatments for human as well as animal diseases when experiments on animals or humans would be unfeasible or considered less ethical. Studying model organisms may be informative, but care must be taken when generalizing from one organism to another. Often, model organisms are chosen on the basis that they are amenable to experimental manipulation. When researchers look for an organism to use in their studies, they look for several traits. Among these are size, generation time, accessibility, manipulation, genetics, conservation of mechanisms and potential economic benefit. As comparative molecular biology has become more common, some researchers have sought model organisms from a wider assortment of lineages on the tree of life. There are many model organisms, such as viruses (e.g., Phage lambda virus, Tobacco mosaic virus, etc., bacteria (e.g., Bacillus subtilis, Escherichia coli, Pseudomonas fluorescens, Vibrio fischeri, etc., algae (e.g., Chlamydomonas reinhardtii, Emiliania huxleyi, etc., molds (e.g., Aspergillus nidulans, Neurospora crassa, etc., yeasts (e.g., Saccharomyces cerevisiae, Ustilago maydis, etc., higher plants (e.g., Arabidopsis thaliana, Lemna gibba, Lotus japonicus, Nicotiana tabaccum, Oryza sativa, Physcomitrella patens, Zea mays, etc. and animals (e.g., Caenorhabditis elegans, guinea pig, hamster, mouse, rat, cat, chicken, dog, frog, Hydra, Drosophila melanogaster fruit fly, fish, etc..

  15. Research collaboration, hazard modeling and dissemination in volcanology with Vhub

    Science.gov (United States)

    Palma Lizana, J. L.; Valentine, G. A.

    2011-12-01

    Vhub (online at vhub.org) is a cyberinfrastructure for collaboration in volcanology research, education, and outreach. One of the core objectives of this project is to accelerate the transfer of research tools to organizations and stakeholders charged with volcano hazard and risk mitigation (such as observatories). Vhub offers a clearinghouse for computational models of volcanic processes and data analysis, documentation of those models, and capabilities for online collaborative groups focused on issues such as code development, configuration management, benchmarking, and validation. A subset of simulations is already available for online execution, eliminating the need to download and compile locally. In addition, Vhub is a platform for sharing presentations and other educational material in a variety of media formats, which are useful in teaching university-level volcanology. VHub also has wikis, blogs and group functions around specific topics to encourage collaboration and discussion. In this presentation we provide examples of the vhub capabilities, including: (1) tephra dispersion and block-and-ash flow models; (2) shared educational materials; (3) online collaborative environment for different types of research, including field-based studies and plume dispersal modeling; (4) workshops. Future goals include implementation of middleware to allow access to data and databases that are stored and maintained at various institutions around the world. All of these capabilities can be exercised with a user-defined level of privacy, ranging from completely private (only shared and visible to specified people) to completely public. The volcanological community is encouraged to use the resources of vhub and also to contribute models, datasets, and other items that authors would like to disseminate. The project is funded by the US National Science Foundation and includes a core development team at University at Buffalo, Michigan Technological University, and University

  16. Advancement in the Development of Models for Hepatitis C Research

    Directory of Open Access Journals (Sweden)

    Wendy C. Carcamo

    2012-01-01

    Full Text Available Hepatitis C virus (HCV is a pandemic disease affecting an estimated 180 million individuals worldwide and infecting each year another ~3-4 million people making HCV a global public health issue. HCV is the main cause for chronic hepatitis, cirrhosis, and hepatocellular carcinoma. In the United States, HCV-related chronic liver disease is a leading cause of liver transplantation. Despite significant improvements in antiviral drugs, only ~50% of treated patients with HCV have viral clearance after treatment. Showing unique species specificity, HCV has a narrow range of potential hosts infecting only chimpanzees and humans. For decades, the chimpanzee model has been the only and instrumental primate for studying HCV infection; however, availability, economic, and ethical issues make the chimpanzee an unsuitable animal model today. Thus, significant research has been devoted to explore different models that are suitable in studying the biology of the virus and application in the clinical research for developing efficient and tolerable treatments for patients. This review focuses on experimental models that have been developed to date and their findings related to HCV.

  17. Ambient Weather Model Research and Development: Final Report.

    Energy Technology Data Exchange (ETDEWEB)

    Walker, Stel Nathan; Wade, John Edward

    1990-08-31

    Ratings for Bonneville Power Administration (BPA) transmission lines are based upon the IEEE Standard for Calculation of Bare Overhead Conductor Temperatures and Ampacity under Steady-State Conditions (1985). This steady-state model is very sensitive to the ambient weather conditions of temperature and wind speed. The model does not account for wind yaw, turbulence, or conductor roughness as proposed by Davis (1976) for a real time rating system. The objective of this research has been to determine (1) how conservative the present rating system is for typical ambient weather conditions, (2) develop a probability-based methodology, (3) compile available weather data into a compatible format, and (4) apply the rating methodology to a hypothetical line. The potential benefit from this research is to rate transmission lines statistically which will allow BPA to take advantage of any unknown thermal capacity. The present deterministic weather model is conservative overall and studies suggest a refined model will uncover additional unknown capacity. 14 refs., 40 figs., 7 tabs.

  18. Research on JD e-commerce's delivery model

    Science.gov (United States)

    Fan, Zhiguo; Ma, Mengkun; Feng, Chaoying

    2017-03-01

    E-commerce enterprises represented by JD have made a great contribution to the economic growth and economic development of our country. Delivery, as an important part of logistics, has self-evident importance. By establishing efficient and perfect self-built logistics systems and building good cooperation models with third-party logistics enterprises, e-commerce enterprises have created their own logistics advantages. Characterized by multi-batch and small-batch, e-commerce is much more complicated than traditional transaction. It's not easy to decide which delivery model e-commerce enterprises should adopt. Having e-commerce's logistics delivery as the main research object, this essay aims to find a more suitable logistics delivery model for JD's development.

  19. The prisoner as model organism: malaria research at Stateville Penitentiary

    Science.gov (United States)

    Comfort, Nathaniel

    2009-01-01

    In a military-sponsored research project begun during the Second World War, inmates of the Stateville Penitentiary in Illinois were infected with malaria and treated with experimental drugs that sometimes had vicious side effects. They were made into reservoirs for the disease and they provided a food supply for the mosquito cultures. They acted as secretaries and technicians, recording data on one another, administering malarious mosquito bites and experimental drugs to one another, and helping decide who was admitted to the project and who became eligible for early parole as a result of his participation. Thus, the prisoners were not simply research subjects; they were deeply constitutive of the research project. Because a prisoner’s time on the project was counted as part of his sentence, and because serving on the project could shorten one’s sentence, the project must be seen as simultaneously serving the functions of research and punishment. Michel Foucault wrote about such ‘mixed mechanisms’ in his Discipline and punish. His shining example of such a ‘transparent’ and subtle style of punishment was the panopticon, Jeremy Bentham’s architectural invention of prison cellblocks arrayed around a central guard tower. Stateville prison was designed on Bentham’s model; Foucault featured it in his own discussion. This paper, then, explores the power relations in this highly idiosyncratic experimental system, in which the various roles of model organism, reagent, and technician are all occupied by sentient beings who move among them fluidly. This, I argue, created an environment in the Stateville hospital wing more panoptic than that in the cellblocks. Research and punishment were completely interpenetrating, and mutually reinforcing. PMID:19720327

  20. The prisoner as model organism: malaria research at Stateville Penitentiary.

    Science.gov (United States)

    Comfort, Nathaniel

    2009-09-01

    In a military-sponsored research project begun during the Second World War, inmates of the Stateville Penitentiary in Illinois were infected with malaria and treated with experimental drugs that sometimes had vicious side effects. They were made into reservoirs for the disease and they provided a food supply for the mosquito cultures. They acted as secretaries and technicians, recording data on one another, administering malarious mosquito bites and experimental drugs to one another, and helping decide who was admitted to the project and who became eligible for early parole as a result of his participation. Thus, the prisoners were not simply research subjects; they were deeply constitutive of the research project. Because a prisoner's time on the project was counted as part of his sentence, and because serving on the project could shorten one's sentence, the project must be seen as simultaneously serving the functions of research and punishment. Michel Foucault wrote about such 'mixed mechanisms' in his Discipline and punish. His shining example of such a 'transparent' and subtle style of punishment was the panopticon, Jeremy Bentham's architectural invention of prison cellblocks arrayed around a central guard tower. Stateville prison was designed on Bentham's model; Foucault featured it in his own discussion. This paper, then, explores the power relations in this highly idiosyncratic experimental system, in which the various roles of model organism, reagent, and technician are all occupied by sentient beings who move among them fluidly. This, I argue, created an environment in the Stateville hospital wing more panoptic than that in the cellblocks. Research and punishment were completely interpenetrating, and mutually reinforcing.

  1. Additional Research Needs to Support the GENII Biosphere Models

    Energy Technology Data Exchange (ETDEWEB)

    Napier, Bruce A.; Snyder, Sandra F.; Arimescu, Carmen

    2013-11-30

    In the course of evaluating the current parameter needs for the GENII Version 2 code (Snyder et al. 2013), areas of possible improvement for both the data and the underlying models have been identified. As the data review was implemented, PNNL staff identified areas where the models can be improved both to accommodate the locally significant pathways identified and also to incorporate newer models. The areas are general data needs for the existing models and improved formulations for the pathway models. It is recommended that priorities be set by NRC staff to guide selection of the most useful improvements in a cost-effective manner. Suggestions are made based on relatively easy and inexpensive changes, and longer-term more costly studies. In the short term, there are several improved model formulations that could be applied to the GENII suite of codes to make them more generally useful. • Implementation of the separation of the translocation and weathering processes • Implementation of an improved model for carbon-14 from non-atmospheric sources • Implementation of radon exposure pathways models • Development of a KML processor for the output report generator module data that are calculated on a grid that could be superimposed upon digital maps for easier presentation and display • Implementation of marine mammal models (manatees, seals, walrus, whales, etc.). Data needs in the longer term require extensive (and potentially expensive) research. Before picking any one radionuclide or food type, NRC staff should perform an in-house review of current and anticipated environmental analyses to select “dominant” radionuclides of interest to allow setting of cost-effective priorities for radionuclide- and pathway-specific research. These include • soil-to-plant uptake studies for oranges and other citrus fruits, and • Development of models for evaluation of radionuclide concentration in highly-processed foods such as oils and sugars. Finally, renewed

  2. Research on the trajectory model for ZY-3.

    Science.gov (United States)

    Chen, Yifu; Xie, Zhong

    2014-01-01

    The new generation Chinese high-resolution three-line stereo-mapping satellite Ziyuan 3 (ZY-3) is equipped with three sensors (nadir, backward, and forward views). Its objective is to manufacture the 1 : 50000 topographic map and revise and update the 1 : 25000 topographic map. For the push-broom satellite, the interpolation accuracy of orbit and attitude determines directly the satellite's stereo-mapping accuracy and the position accuracy without ground control point. In this study, a new trajectory model is proposed for ZY-3 in this paper, according to researching and analyzing the orbit and attitude of ZY-3. Using the trajectory data set, the correction and accuracy of the new proposed trajectory are validated and compared with the other models, polynomial model (LPM), piecewise polynomial model (PPM), and Lagrange cubic polynomial model (LCPM). Meanwhile, the differential equation is derivate for the bundle block adjustment. Finally, the correction and practicability of piece-point with weight polynomial model for ZY-3 satellite are validated according to the experiment of geometric correction using the ZY-3 image and orbit and attitude data.

  3. Research on the Trajectory Model for ZY-3

    Directory of Open Access Journals (Sweden)

    Yifu Chen

    2014-01-01

    Full Text Available The new generation Chinese high-resolution three-line stereo-mapping satellite Ziyuan 3 (ZY-3 is equipped with three sensors (nadir, backward, and forward views. Its objective is to manufacture the 1 : 50000 topographic map and revise and update the 1 : 25000 topographic map. For the push-broom satellite, the interpolation accuracy of orbit and attitude determines directly the satellite’s stereo-mapping accuracy and the position accuracy without ground control point. In this study, a new trajectory model is proposed for ZY-3 in this paper, according to researching and analyzing the orbit and attitude of ZY-3. Using the trajectory data set, the correction and accuracy of the new proposed trajectory are validated and compared with the other models, polynomial model (LPM, piecewise polynomial model (PPM, and Lagrange cubic polynomial model (LCPM. Meanwhile, the differential equation is derivate for the bundle block adjustment. Finally, the correction and practicability of piece-point with weight polynomial model for ZY-3 satellite are validated according to the experiment of geometric correction using the ZY-3 image and orbit and attitude data.

  4. LNG Safety Research: FEM3A Model Development

    Energy Technology Data Exchange (ETDEWEB)

    Liese Dallbauman

    2004-06-30

    During this reporting period, kickoff and planning meetings were held. Subcontracted experimental and modeling tasks were defined. Efforts to address the numerical stability problems that hamper FEM3A's applicability to low wind speed, stable atmospheric conditions were initiated. A detailed review of FEM3A code and its execution, required for development of an accessible user interface, was also begun. A one-day workshop on LNG safety models has been scheduled for September 2004. The goals of this project are to develop a national focal point for LNG safety research and technical dissemination and to develop the FEM3A dispersion model for application to general scenarios involving dispersion problems with obstacle and terrain features of realistic complexity. During this reporting period, the objectives and scope of the project and its constituent tasks were discussed at a project kickoff meeting in Morgantown. Details of the subcontracted experimental and modeling tasks were further defined at a separate meeting at the University of Arkansas. Researchers at the university have begun to modify the turbulence closure model used in FEM3A to insure numerical stability during simulation of low-wind-speed, stable atmospheric conditions. The university's wind tunnel is being prepared for upcoming experimental studies. GTI has begun a detailed review of the FEM3A code and its execution that will provide guidance during development of an accessible user interface. Plans were made for a one day workshop on LNG safety models that will be held at the end of September and will provide an introduction to currently available and pending software tools.

  5. Modelling as an indispensible research tool in the information society.

    Science.gov (United States)

    Bouma, Johan

    2016-04-01

    Science and society would be well advised to develop a different relationship as the information revolution penetrates all aspects of modern life. Rather than produce clear answers to clear questions in a top-down manner, land-use issues related to the UN Sustainable Development Goals (SDGs) present "wicked"problems involving different, strongly opiniated, stakeholders with conflicting ideas and interests and risk-averse politicians. The Dutch government has invited its citizens to develop a "science agenda", defining future research needs, implicitly suggesting that the research community is unable to do so. Time, therefore, for a pro-active approach to more convincingly define our:"societal license to research". For soil science this could imply a focus on the SDGs , considering soils as living, characteristically different, dynamic bodies in a landscape, to be mapped in ways that allow generation of suitable modelling data. Models allow a dynamic characterization of water- and nutrient regimes and plant growth in soils both for actual and future conditions, reflecting e.g. effects of climate or land-use change or alternative management practices. Engaging modern stakeholders in a bottom-up manner implies continuous involvement and "joint learning" from project initiation to completion, where modelling results act as building blocks to explore alternative scenarios. Modern techniques allow very rapid calculations and innovative visualization. Everything is possible but only modelling can articulate the economic, social and environmental consequences of each scenario, demonstrating in a pro-active manner the crucial and indispensible role of research. But choices are to be made by stakeholders and reluctant policy makers and certainly not by scientists who should carefully guard their independance. Only clear results in the end are convincing proof for the impact of science, requiring therefore continued involvement of scientists up to the very end of projects. To

  6. Research on Evacuation Based on Social Force Model

    Science.gov (United States)

    Liu, W.; Deng, Z.; Li, W.; Lin, J.

    2017-09-01

    Crowded centers always cause personnel casualties in evacuation operations. Stampede events often occur by hit, squeeze and crush due to panic. It is of vital important to alleviate such situation. With the deepening of personnel evacuation research, more and more researchers are committed to study individual behaviors and self-organization phenomenon in evacuation process. The study mainly includes: 1, enrich the social force model from different facets such as visual, psychological, external force to descript more realistic evacuation; 2, research on causes and effects of self - organization phenomenon. In this paper, we focus on disorder motion that occurs in the crowded indoor publics, especially the narrow channel and safety exits and other special arteries. We put forward the improved social force model to depict pedestrians' behaviors, an orderly speed-stratification evacuation method to solve disorder problem, and shape-changed export to alleviate congestion. The result of this work shows an improvement of evacuation efficiency by 19.5 %. Guiding pedestrians' direction to slow down the influence of social forces has a guidance function in improving the efficiency of indoor emergency evacuation.

  7. Logistic regression for risk factor modelling in stuttering research.

    Science.gov (United States)

    Reed, Phil; Wu, Yaqionq

    2013-06-01

    To outline the uses of logistic regression and other statistical methods for risk factor analysis in the context of research on stuttering. The principles underlying the application of a logistic regression are illustrated, and the types of questions to which such a technique has been applied in the stuttering field are outlined. The assumptions and limitations of the technique are discussed with respect to existing stuttering research, and with respect to formulating appropriate research strategies to accommodate these considerations. Finally, some alternatives to the approach are briefly discussed. The way the statistical procedures are employed are demonstrated with some hypothetical data. Research into several practical issues concerning stuttering could benefit if risk factor modelling were used. Important examples are early diagnosis, prognosis (whether a child will recover or persist) and assessment of treatment outcome. After reading this article you will: (a) Summarize the situations in which logistic regression can be applied to a range of issues about stuttering; (b) Follow the steps in performing a logistic regression analysis; (c) Describe the assumptions of the logistic regression technique and the precautions that need to be checked when it is employed; (d) Be able to summarize its advantages over other techniques like estimation of group differences and simple regression. Copyright © 2012 Elsevier Inc. All rights reserved.

  8. Cooperative Fish and Wildlife Research Units - A model partnership program

    Science.gov (United States)

    Dennerline, Donald E.; Childs, Dawn E.

    2017-04-20

    The U.S. Geological Survey (USGS) Cooperative Fish and Wildlife Research Units (CRU) program is a unique model of cooperative partnership among the USGS, other U.S. Department of the Interior and Federal agencies, universities, State fish and wildlife agencies, and the Wildlife Management Institute. These partnerships are maintained as one of the USGS’s strongest links to Federal and State land and natural resource management agencies.Established in 1935 to meet the need for trained professionals in the growing field of wildlife management, the program currently consists of 40 Cooperative Fish and Wildlife Research Units located on university campuses in 38 States and supports 119 research scientist positions when fully funded. The threefold mission of the CRU program is to (1) conduct scientific research for the management of fish, wildlife, and other natural resources; (2) provide technical assistance to natural resource managers in the application of scientific information to natural resource policy and management; and (3) train future natural resource professionals.

  9. Research of inverse mathematical model to high-speed trains

    Institute of Scientific and Technical Information of China (English)

    朱涛; 肖守讷; 马卫华; 阳光武

    2014-01-01

    Operation safety and stability of the train mainly depend on the interaction between the wheel and rail. Knowledge of wheel/rail contact force is important for vehicle control systems that aim to enhance vehicle stability and passenger safety. Since wheel/rail contact forces of high-speed train are very difficult to measure directly, a new estimation process for wheel/rail contact forces was introduced in this work. Based on the state space equation, dynamic programming methods and the Bellman principle of optimality, the main theoretical derivation of the inversion mathematical model was given. The new method overcomes the weakness of large fluctuations which exist in current inverse techniques. High-speed vehicle was chosen as the research object, accelerations of axle box as input conditions, 10 degrees of freedom vertical vibration model and 17 degrees of freedom lateral vibration model were established, respectively. Under 250 km/h, the vertical and lateral wheel/rail forces were identified. From the time domain and frequency domain, the comparison of the results between inverse and SIMPACK models were given. The results show that the inverse mathematical model has high precision for inversing the wheel/rail contact forces of an operation high-speed vehicle.

  10. 3D Printing of Biomolecular Models for Research and Pedagogy

    Science.gov (United States)

    Da Veiga Beltrame, Eduardo; Tyrwhitt-Drake, James; Roy, Ian; Shalaby, Raed; Suckale, Jakob; Pomeranz Krummel, Daniel

    2017-01-01

    The construction of physical three-dimensional (3D) models of biomolecules can uniquely contribute to the study of the structure-function relationship. 3D structures are most often perceived using the two-dimensional and exclusively visual medium of the computer screen. Converting digital 3D molecular data into real objects enables information to be perceived through an expanded range of human senses, including direct stereoscopic vision, touch, and interaction. Such tangible models facilitate new insights, enable hypothesis testing, and serve as psychological or sensory anchors for conceptual information about the functions of biomolecules. Recent advances in consumer 3D printing technology enable, for the first time, the cost-effective fabrication of high-quality and scientifically accurate models of biomolecules in a variety of molecular representations. However, the optimization of the virtual model and its printing parameters is difficult and time consuming without detailed guidance. Here, we provide a guide on the digital design and physical fabrication of biomolecule models for research and pedagogy using open source or low-cost software and low-cost 3D printers that use fused filament fabrication technology. PMID:28362403

  11. CERIF: The Common European Research Information Format Model

    Directory of Open Access Journals (Sweden)

    Brigitte Jörg

    2010-09-01

    Full Text Available With increased computing power more data than ever are being and will be produced, stored and (re- used. Data are collected in databases, computed and annotated, or transformed by specific tools. The knowledge from data is documented in research publications, reports, presentations, or other types of files. The management of data and knowledge is difficult, and even more complicated is their re-use, exchange, or integration. To allow for quality analysis or integration across data sets and to ensure access to scientific knowledge, additional information - Research Information - has to be assigned to data and knowledge entities. We present the metadata model CERIF to add information to entities such as Publication, Project, Organisation, Person, Product, Patent, Service, Equipment, and Facility and to manage the semantically enhanced relationships between these entities in a formalized way. CERIF has been released as an EC Recommendation to European Member States in 2000. Here, we refer to the latest version CERIF 2008-1.0.

  12. The interpersonal circle as a heuristic model for interpersonal research.

    Science.gov (United States)

    Lorr, M

    1996-04-01

    In this article, I review major advances in the development of the interpersonal circle and its measurement, as delineated by Timothy Leafy (1957) and his colleagues. In my early work (Lorr & McNair, 1963, 1965), an interpersonal Behavior Inventory consisting of manifest behavioral statements was constructed. The 14 categories were found to fit a circular order in several samples. Studies using LaForge and Suczek's (1955) Interpersonal Check List, and Wiggins's (1979) Interpersonal Adjective Scales further established the value of Leary's conceptions and extended them. Several major theorists, researchers, and clinicians including Benjamin, Carson, Horowitz, Kiesler, and Wiggins have been inspired by Leary and, in many cases, have extended his ideas in ways not originally envisioned. Recent research (e.g., Hofstee, de Raad, & Goldberg, 1992; Millon, 1987) demonstrated the pertinence of the interpersonal conception of personality to the 5-factor model and personality disorders.

  13. A Correlation Analysis Model for Multidisciplinary Data in Disaster Research

    Directory of Open Access Journals (Sweden)

    Hongyue Zhang

    2015-05-01

    Full Text Available Data play an important role in disaster mitigation applications, and the integrated employment of multidisciplinary data promotes the development of disaster science. Therefore it is very useful to identify the multidisciplinary data usage in the research of disaster events. In order to discover the correlation between multidisciplinary data and disaster research, three earthquake events, the Tangshan earthquake, the Wenchuan earthquake, and the Haidi earthquake were selected as typical study cases for this paper. A knowledge model for literature data mining was applied to analyze the correlation between earthquake events and multidisciplinary data types. The results indicate that high-cited papers show different data usage trends when compared with whole-set papers and also that data usage for the three earthquake events varies. According to analysis results, the factors that influence multidisciplinary data usage include the characteristics of spatial and temporal elements as well as differing interests of the data users.

  14. Fire in the Earth System: Bridging data and modeling research

    Science.gov (United States)

    Hantson, Srijn; Kloster, Silvia; Coughlan, Michael; Daniau, Anne-Laure; Vanniere, Boris; Bruecher, Tim; Kehrwald, Natalie; Magi, Brian I.

    2016-01-01

    Significant changes in wildfire occurrence, extent, and severity in areas such as western North America and Indonesia in 2015 have made the issue of fire increasingly salient in both the public and scientific spheres. Biomass combustion rapidly transforms land cover, smoke pours into the atmosphere, radiative heat from fires initiates dramatic pyrocumulus clouds, and the repeated ecological and atmospheric effects of fire can even impact regional and global climate. Furthermore, fires have a significant impact on human health, livelihoods, and social and economic systems.Modeling and databased methods to understand fire have rapidly coevolved over the past decade. Satellite and ground-based data about present-day fire are widely available for applications in research and fire management. Fire modeling has developed in part because of the evolution in vegetation and Earth system modeling efforts, but parameterizations and validation are largely focused on the present day because of the availability of satellite data. Charcoal deposits in sediment cores have emerged as a powerful method to evaluate trends in biomass burning extending back to the Last Glacial Maximum and beyond, and these records provide a context for present-day fire. The Global Charcoal Database version 3 compiled about 700 charcoal records and more than 1,000 records are expected for the future version 4. Together, these advances offer a pathway to explore how the strengths of fire data and fire modeling could address the weaknesses in the overall understanding of human-climate–fire linkages.A community of researchers studying fire in the Earth system with individual expertise that included paleoecology, paleoclimatology, modern ecology, archaeology, climate, and Earth system modeling, statistics, geography, biogeochemistry, and atmospheric science met at an intensive workshop in Massachusetts to explore new research directions and initiate new collaborations. Research themes, which emerged from

  15. Animal models for implant biomaterial research in bone: A review

    Directory of Open Access Journals (Sweden)

    A I Pearce

    2007-03-01

    Full Text Available Development of an optimal interface between bone and orthopaedic and dental implants has taken place for many years. In order to determine whether a newly developed implant material conforms to the requirements of biocompatibility, mechanical stability and safety, it must undergo rigorous testing both in vitro and in vivo. Results from in vitro studies can be difficult to extrapolate to the in vivo situation. For this reason the use of animal models is often an essential step in the testing of orthopaedic and dental implants prior to clinical use in humans. This review discusses some of the more commonly available and frequently used animal models such as the dog, sheep, goat, pig and rabbit models for the evaluation of bone-implant interactions. Factors for consideration when choosing an animal model and implant design are discussed. Various bone specific features are discussed including the usage of the species, bone macrostructure and microstructure and bone composition and remodelling, with emphasis being placed on the similarity between the animal model and the human clinical situation. While the rabbit was the most commonly used of the species discussed in this review, it is clear that this species showed the least similarities to human bone. There were only minor differences in bone composition between the various species and humans. The pig demonstrated a good likeness with human bone however difficulties may be encountered in relation to their size and ease of handling. In this respect the dog and sheep/goat show more promise as animal models for the testing of bone implant materials. While no species fulfils all of the requirements of an ideal model, an understanding of the differences in bone architecture and remodelling between the species is likely to assist in the selection of a suitable species for a defined research question.

  16. Gravity research on plants: use of single cell experimental models

    Directory of Open Access Journals (Sweden)

    Youssef eChebli

    2011-09-01

    Full Text Available Future space missions and implementation of permanent bases on Moon and Mars will greatly depend on the availability of ambient air and sustainable food supply. Therefore, understanding the effects of altered gravity conditions on plant metabolism and growth is vital for space missions and extra-terrestrial human existence. In this mini-review we summarize how plant cells are thought to perceive changes in magnitude and orientation of the gravity vector. The particular advantages of several single celled model systems for gravity research are explored and an overview over recent advancements and potential use of these systems is provided.

  17. Analysis of NASA Common Research Model Dynamic Data

    Science.gov (United States)

    Balakrishna, S.; Acheson, Michael J.

    2011-01-01

    Recent NASA Common Research Model (CRM) tests at the Langley National Transonic Facility (NTF) and Ames 11-foot Transonic Wind Tunnel (11-foot TWT) have generated an experimental database for CFD code validation. The database consists of force and moment, surface pressures and wideband wing-root dynamic strain/wing Kulite data from continuous sweep pitch polars. The dynamic data sets, acquired at 12,800 Hz sampling rate, are analyzed in this study to evaluate CRM wing buffet onset and potential CRM wing flow separation.

  18. Game Modeling Research for Urbanization and Epidemic Control

    Institute of Scientific and Technical Information of China (English)

    Bai-Da Qu

    2005-01-01

    To aid in the sustainable development of cities this paper examines methods for urbanization and epidemic control. Using, as a foundation, game theory from modern control theory, a set of strategies for modeling urbanization and epidemic control are examined by analyzing and studying the current condition of China including its population, economy,resources and city management methods. Urbanization and epidemic control solving strategies are probed and the solution to a simulated example is provided. The conclusion from this research is that the speed of Chinese urbanization should be slowed to match the condition of resources and level of city management available.

  19. Research Challenges in Financial Data Modeling and Analysis.

    Science.gov (United States)

    Alexander, Lewis; Das, Sanjiv R; Ives, Zachary; Jagadish, H V; Monteleoni, Claire

    2017-09-01

    Significant research challenges must be addressed in the cleaning, transformation, integration, modeling, and analytics of Big Data sources for finance. This article surveys the progress made so far in this direction and obstacles yet to be overcome. These are issues that are of interest to data-driven financial institutions in both corporate finance and consumer finance. These challenges are also of interest to the legal profession as well as to regulators. The discussion is relevant to technology firms that support the growing field of FinTech.

  20. Longitudinal Omics Modelling and Integration in Clinical Metabonomics Research: challenges in childhood metabolic health research

    Directory of Open Access Journals (Sweden)

    Peter eSperisen

    2015-08-01

    Full Text Available Systems biology is an important approach for deciphering the complex processes in health maintenance and the etiology of metabolic diseases. Such integrative methodologies will help better understand the molecular mechanisms involved in growth and development throughout childhood, and consequently will result in new insights about metabolic and nutritional requirements of infants, children and adults. To achieve this, a better understanding of the physiological processes at anthropometric, cellular and molecular level for any given individual is needed. In this respect, novel omics technologies in combination with sophisticated data modelling techniques are key. Due to the highly complex network of influential factors determining individual trajectories, it becomes imperative to develop proper tools and solutions that will comprehensively model biological information related to growth and maturation of our body functions. The aim of this review and perspective is to evaluate, succinctly, promising data analysis approaches to enable data integration for clinical research, with an emphasis on the longitudinal component. Approaches based on empirical and mechanistic modelling of omics data are essential to leverage findings from high dimensional omics datasets and enable biological interpretation and clinical translation. On the one hand, empirical methods, which provide quantitative descriptions of patterns in the data, are mostly used for exploring and mining datasets. On the other hand, mechanistic models are based on an understanding of the behavior of a system’s components and condense information about the known functions, allowing robust and reliable analyses to be performed by bioinformatics pipelines and similar tools. Herein, we will illustrate current examples, challenges and perspectives in the applications of empirical and mechanistic modelling in the context of childhood metabolic health research.

  1. Complexity and agent-based modelling in urban research

    DEFF Research Database (Denmark)

    Fertner, Christian

    Urbanisation processes are results of a broad variety of actors or actor groups and their behaviour and decisions based on different experiences, knowledge, resources, values etc. The decisions done are often on a micro/individual level but resulting in macro/collective behaviour. In urban research...... influence on the bigger system. Traditional scientific methods or theories often tried to simplify, not accounting complex relations of actors and decision-making. The introduction of computers in simulation made new approaches in modelling, as for example agent-based modelling (ABM), possible, dealing...... of complexity for a majority of science, there exists a huge number of scientific articles, books, tutorials etc. to these topics which doesn’t make it easy for a novice in the field to find the right literature. The literature used gives an optimistic outlook for the future of this methodology, although ABM...

  2. Instrumental and ethical aspects of experimental research with animal models

    Directory of Open Access Journals (Sweden)

    Mirian Watanabe

    2014-02-01

    Full Text Available Experimental animal models offer possibilities of physiology knowledge, pathogenesis of disease and action of drugs that are directly related to quality nursing care. This integrative review describes the current state of the instrumental and ethical aspects of experimental research with animal models, including the main recommendations of ethics committees that focus on animal welfare and raises questions about the impact of their findings in nursing care. Data show that, in Brazil, the progress in ethics for the use of animals for scientific purposes was consolidated with Law No. 11.794/2008 establishing ethical procedures, attending health, genetic and experimental parameters. The application of ethics in handling of animals for scientific and educational purposes and obtaining consistent and quality data brings unquestionable contributions to the nurse, as they offer subsidies to relate pathophysiological mechanisms and the clinical aspect on the patient.

  3. Research Spotlight: Improved model reproduces the 2003 European heat wave

    Science.gov (United States)

    Schultz, Colin

    2011-04-01

    In August 2003, record-breaking temperatures raged across much of Europe. In France, maximum temperatures of 37°C (99°F) persisted for 9 days straight, the longest such stretch since 1873. About 40,000 deaths (14,000 in France alone) were attributed to the extreme heat and low humidity. Various climate conditions must come into alignment to produce extreme weather like the 2003 heat wave, and despite a concerted effort, forecasting models have so far been unable to accurately reproduce the event—including the modern European Centre for Medium-Range Weather Forecasts (ECMWF) ensemble modeling system for seasonal forecasts, which went into operation in 2007. (Geophysical Research Letters, doi:10.1029/2010GL046455, 2011)

  4. Research on teacher education programs: logic model approach.

    Science.gov (United States)

    Newton, Xiaoxia A; Poon, Rebecca C; Nunes, Nicole L; Stone, Elisa M

    2013-02-01

    Teacher education programs in the United States face increasing pressure to demonstrate their effectiveness through pupils' learning gains in classrooms where program graduates teach. The link between teacher candidates' learning in teacher education programs and pupils' learning in K-12 classrooms implicit in the policy discourse suggests a one-to-one correspondence. However, the logical steps leading from what teacher candidates have learned in their programs to what they are doing in classrooms that may contribute to their pupils' learning are anything but straightforward. In this paper, we argue that the logic model approach from scholarship on evaluation can enhance research on teacher education by making explicit the logical links between program processes and intended outcomes. We demonstrate the usefulness of the logic model approach through our own work on designing a longitudinal study that focuses on examining the process and impact of an undergraduate mathematics and science teacher education program.

  5. Animal models of osteogenesis imperfecta: applications in clinical research

    Directory of Open Access Journals (Sweden)

    Enderli TA

    2016-09-01

    Full Text Available Tanya A Enderli, Stephanie R Burtch, Jara N Templet, Alessandra Carriero Department of Biomedical Engineering, Florida Institute of Technology, Melbourne, FL, USA Abstract: Osteogenesis imperfecta (OI, commonly known as brittle bone disease, is a genetic disease characterized by extreme bone fragility and consequent skeletal deformities. This connective tissue disorder is caused by mutations in the quality and quantity of the collagen that in turn affect the overall mechanical integrity of the bone, increasing its vulnerability to fracture. Animal models of the disease have played a critical role in the understanding of the pathology and causes of OI and in the investigation of a broad range of clinical therapies for the disease. Currently, at least 20 animal models have been officially recognized to represent the phenotype and biochemistry of the 17 different types of OI in humans. These include mice, dogs, and fish. Here, we describe each of the animal models and the type of OI they represent, and present their application in clinical research for treatments of OI, such as drug therapies (ie, bisphosphonates and sclerostin and mechanical (ie, vibrational loading. In the future, different dosages and lengths of treatment need to be further investigated on different animal models of OI using potentially promising treatments, such as cellular and chaperone therapies. A combination of therapies may also offer a viable treatment regime to improve bone quality and reduce fragility in animals before being introduced into clinical trials for OI patients. Keywords: OI, brittle bone, clinical research, mouse, dog, zebrafish

  6. Experimental Research and Mathematical Modelling for Coal Reburning in Furnace

    Institute of Scientific and Technical Information of China (English)

    XIANG Jun; SU Sheng; SUN Lu-shi; SUN Xue-xin; ZHANG Zhong-xiao; ZHU Ji-mu

    2006-01-01

    Reburning technology is one of the most cost-effective NOx reduction strategies for coal combustion systems. In this paper, a nitric oxide submodel incorporated into a comprehensive coal combustion model was developed for predicting NOx reduction in a 93 kW laboratory-scale coal combustion furnace by reburning. This NO submodel, including reburning mechanism, requires the solution of only two transport equations to model the behavior of NO reduction in the reburning process. A number of experiments have been performed in the same furnace, and the experimental data obtained from the optimized reburn configuration was used to validate the model. Measurements and predictions both show above 50% reduction of NO emissions for the optimized reburning process. Profile comparisons show that the predicted temperature and oxygen concentration match well with the measurements, and the general trend of predicted NO concentration is very similar to that measured. The results of this study show that the present nitric oxide submodel depicts quite well the observed behaviour of NO annihilation in the reburning process. It is expected that this usable and computationally economic model represents a useful tool to simulate the gaseous fuel reburning process for the researchers concerned with practical combustors.

  7. Modeling Influenza Virus Infection: A Roadmap for Influenza Research

    Directory of Open Access Journals (Sweden)

    Alessandro Boianelli

    2015-10-01

    Full Text Available Influenza A virus (IAV infection represents a global threat causing seasonal outbreaks and pandemics. Additionally, secondary bacterial infections, caused mainly by Streptococcus pneumoniae, are one of the main complications and responsible for the enhanced morbidity and mortality associated with IAV infections. In spite of the significant advances in our knowledge of IAV infections, holistic comprehension of the interplay between IAV and the host immune response (IR remains largely fragmented. During the last decade, mathematical modeling has been instrumental to explain and quantify IAV dynamics. In this paper, we review not only the state of the art of mathematical models of IAV infection but also the methodologies exploited for parameter estimation. We focus on the adaptive IR control of IAV infection and the possible mechanisms that could promote a secondary bacterial coinfection. To exemplify IAV dynamics and identifiability issues, a mathematical model to explain the interactions between adaptive IR and IAV infection is considered. Furthermore, in this paper we propose a roadmap for future influenza research. The development of a mathematical modeling framework with a secondary bacterial coinfection, immunosenescence, host genetic factors and responsiveness to vaccination will be pivotal to advance IAV infection understanding and treatment optimization.

  8. The Research on Modeling and Simulation of TFE Polymerization Process

    Directory of Open Access Journals (Sweden)

    Jing Gao Sun

    2014-01-01

    Full Text Available PTFE (polytetrafluoroethylene is the fluorinated straight-chain polymer, made by the polymerization of tetrafluoroethylene monomer; it is used widely because of its excellent performance and can be obtained by the polymerization of body, solutions, suspensions, and emulsions. But only the last two are the main ways. This research paper makes simulation based on Polymer Plus. It uses the emulsion polymerization method at background to carry out a semibatch reactor system. Upon the actual production conditions, simulation process under the steady state conditions is used to analyze the effects of the changes on operating conditions; the corresponding dynamic model is created to analyze the impact of the changes of conditions on the entire system. Moreover, the amount of APS which plays an important part in this reaction is discussed for getting the most suitable amount of initiator. Because of less research work on this job, it is so difficult to find the related data from the literature. Therefore, this research will have a great significance for the process of the tetrafluoroethylene emulsion polymerization in the future.

  9. Broadening participation in Research Experiences for Undergraduates (REU) programs: an evaluation of the team research model for undergraduate research experiences

    Science.gov (United States)

    Berthelote, A. R.; Geraghty Ward, E. M.; Dalbotten, D. M.

    2014-12-01

    The REU site on sustainable land and water resources has a goal of broadening participation in the geosciences by underrepresented groups and particularly Native American students. We are evaluating modifications to the traditional REU model in order to better support these students. First, we review a team research model for REU students, where students are placed on teams and work together in peer groups supported by a team of mentors. Second, the REU takes place in locations that have high populations of Native American students to remove barriers to participation for non-traditional students. Finally, the teams do research on issues related to local concerns with cultural focus. Traditional REU models (1 faculty to 1 student/on campus) have been shown to be effective in supporting student movement into graduate programs but often fail to attract a diverse group of candidates. In addition, they rely for success on the relationship between faculty and student, which can often be undermined by unrealistic expectations on the part of the student about the mentor relationship, and can be exacerbated by cultural misunderstanding, conflicting discourse, or students' personal or family issues. At this REU site, peer mentorship and support plays a large role. Students work together to select their research question, follow the project to completion and present the results. Students from both native and non-native backgrounds learn about the culture of the partner reservations and work on a project that is of immediate local concern. The REU also teaches students protocols for working on Native American lands that support good relations between reservation and University. Analysis of participant data gathered from surveys and interview over the course of our 3-year program indicates that the team approach is successful. Students noted that collaborating with other teams was rewarding and mentors reported positively about their roles in providing guidance for the student

  10. Towards a standard model for research in agent-based modeling and simulation

    Directory of Open Access Journals (Sweden)

    Nuno Fachada

    2015-11-01

    Full Text Available Agent-based modeling (ABM is a bottom-up modeling approach, where each entity of the system being modeled is uniquely represented as an independent decision-making agent. ABMs are very sensitive to implementation details. Thus, it is very easy to inadvertently introduce changes which modify model dynamics. Such problems usually arise due to the lack of transparency in model descriptions, which constrains how models are assessed, implemented and replicated. In this paper, we present PPHPC, a model which aims to serve as a standard in agent based modeling research, namely, but not limited to, conceptual model specification, statistical analysis of simulation output, model comparison and parallelization studies. This paper focuses on the first two aspects (conceptual model specification and statistical analysis of simulation output, also providing a canonical implementation of PPHPC. The paper serves as a complete reference to the presented model, and can be used as a tutorial for simulation practitioners who wish to improve the way they communicate their ABMs.

  11. Noise Simulations of the High-Lift Common Research Model

    Science.gov (United States)

    Lockard, David P.; Choudhari, Meelan M.; Vatsa, Veer N.; O'Connell, Matthew D.; Duda, Benjamin; Fares, Ehab

    2017-01-01

    The PowerFLOW(TradeMark) code has been used to perform numerical simulations of the high-lift version of the Common Research Model (HL-CRM) that will be used for experimental testing of airframe noise. Time-averaged surface pressure results from PowerFLOW(TradeMark) are found to be in reasonable agreement with those from steady-state computations using FUN3D. Surface pressure fluctuations are highest around the slat break and nacelle/pylon region, and synthetic array beamforming results also indicate that this region is the dominant noise source on the model. The gap between the slat and pylon on the HL-CRM is not realistic for modern aircraft, and most nacelles include a chine that is absent in the baseline model. To account for those effects, additional simulations were completed with a chine and with the slat extended into the pylon. The case with the chine was nearly identical to the baseline, and the slat extension resulted in higher surface pressure fluctuations but slightly reduced radiated noise. The full-span slat geometry without the nacelle/pylon was also simulated and found to be around 10 dB quieter than the baseline over almost the entire frequency range. The current simulations are still considered preliminary as changes in the radiated acoustics are still being observed with grid refinement, and additional simulations with finer grids are planned.

  12. Overview of cost-consequence modeling in outcomes research.

    Science.gov (United States)

    Stergachis, A

    1995-01-01

    Outcomes research has developed in response to the need for information on costs, risks, and benefits of clinical treatments, including data regarding the effectiveness of prescription drugs. It attempts to consider more than the biologic effects of pharmaceuticals, that is, to encompass wider measures of the results of their use, issues that are not routinely addressed during clinical trials. Cost-effectiveness analysis compares the outcome of different treatment options in terms of monetary cost per unit of effectiveness. Examples of measures of effectiveness are years of life saved, number of days of hospitalization avoided, and number of treatment successes. Cost-consequence models, also referred to as cost-outcome models, deal with costs and a variety of outcomes ranging from clinical to humanistic. Direct medical costs are those for prevention, detection, treatment, and rehabilitation; they are amounts spent to treat an illness, including hospitalization, professional services, pharmaceuticals, and medical supplies. Indirect medical costs are associated with changes in productivity, such as earnings lost because of illness. Humanistic outcomes deal primarily with functional status, quality of life, and satisfaction, and may include pain, anxiety, self-esteem, ability to carry out normal activities, and overall impressions. Since it is not possible to study all effects of treatments with clinical trials, modeling techniques are useful in making therapeutic decisions.

  13. Bioengineered models of solid human tumors for cancer research

    Science.gov (United States)

    Marturano-Kruik, Alessandro; Villasante, Aranzazu; Vunjak-Novakovic, Gordana

    2016-01-01

    Summary The lack of controllable in vitro models that can recapitulate the features of solid tumors such as Ewing’s sarcoma limits our understanding of the tumor initiation and progression and impedes the development of new therapies. Cancer research still relies of the use of simple cell culture, tumor spheroids, and small animals. Tissue-engineered tumor models are now being grown in vitro to mimic the actual tumors in patients. Recently, we have established a new protocol for bioengineering the Ewing’s sarcoma, by infusing tumor cell aggregates into the human bone engineered from the patient’s mesenchymal stem cells. The bone niche allows crosstalk between the tumor cells, osteoblasts and supporting cells of the bone, extracellular matrix and the tissue microenvironment. The bioreactor platform used in these experiments also allows the implementation of physiologically relevant mechanical signals. Here, we describe a method to build an in vitro model of Ewing’s sarcoma that mimics the key properties of the native tumor and provides the tissue context and physical regulatory signals. PMID:27115504

  14. A model for successful research partnerships: a New Brunswick experience.

    Science.gov (United States)

    Tamlyn, Karen; Creelman, Helen; Fisher, Garfield

    2002-01-01

    The purpose of this paper is to present an overview of a partnership model used to conduct a research study entitled "Needs of patients with cancer and their family members in New Brunswick Health Region 3 (NBHR3)" (Tamlyn-Leaman, Creelman, & Fisher, 1997). This partial replication study carried out by the three authors between 1995 and 1997 was a needs assessment, adapted with permission from previous work by Fitch, Vachon, Greenberg, Saltmarche, and Franssen (1993). In order to conduct a comprehensive needs assessment with limited resources, a partnership between academic, public, and private sectors was established. An illustration of this partnership is presented in the model entitled "A Client-Centred Partnership Model." The operations of this partnership, including the strengths, the perceived benefits, lessons learned by each partner, the barriers, and the process for conflict resolution, are described. A summary of the cancer care initiatives undertaken by NBHR3, which were influenced directly or indirectly by the recommendations from this study, is included.

  15. Research-design model for professional development of teachers: Designing lessons with physics education research

    Directory of Open Access Journals (Sweden)

    Esther Bagno

    2006-09-01

    Full Text Available How can one increase the awareness of teachers to the existence and importance of knowledge gained through physics education research (PER and provide them with capabilities to use it? How can one enrich teachers’ physics knowledge and the related pedagogical content knowledge of topics singled out by PER? In this paper we describe a professional development model that attempts to respond to these needs. We report on a study of the model’s implementation in a program for 22 high-school experienced physics teachers. In this program teachers (in teams of 5-6 developed during a year and a half (about 330 h , several lessons (minimodules dealing with a topic identified as problematic by PER. The teachers employed a systematic research-based approach and used PER findings. The program consisted of three stages, each culminating with a miniconference: 1. Defining teaching and/or learning goals based on content analysis and diagnosis of students’ prior knowledge. 2. Designing the lessons using PER-based instructional strategies. 3. Performing a small-scale research study that accompanies the development process and publishing the results. We describe a case study of one of the groups and bring evidence that demonstrates how the workshop advanced: (a Teachers’ awareness of deficiencies in their own knowledge of physics and pedagogy, and their perceptions about their students’ knowledge; (b teachers’ knowledge of physics and physics pedagogy; (c a systematic research-based approach to the design of lessons; (d the formation of a community of practice; and (e acquaintance with central findings of PER. There was a clear effect on teachers’ practice in the context of the study as indicated by the materials brought to the workshop. The teachers also reported that they continued to use the insights gained, mainly in the topics that were investigated by themselves and by their peers.

  16. Astronomy across State Lines: A Collaborative Model for Astronomical Research

    Science.gov (United States)

    Johnson, Chelen H.; Barge, Jacqueline; Linahan, Marcella; York, Donald G.; Cante, David; Cook, Mary; Daw, Maeve; Donahoe, Katherine E.; Ford, Sydney; Haecker, Lille W.; Hibbs, Cecily A.; Hogan, Eleanor B.; Karos, Demetra N.; Kozikowski, Kendall G.; Martin, Taylor A.; Miranda, Fernando; Ng, Emily; Noel, Imany; O'Bryan, Sophie E.; Sharma, Vikrant; Zegeye, David

    2015-01-01

    Scientists do not work in isolation, nor should student scientists. In a collaborative effort, students from three high schools examined plates from the Sloan Digital Sky Survey (SDSS) to estimate the number of galaxies that contain evidence of a black hole. Working under the direction of Don York, former SDSS director, the three teachers used Google hangouts to discuss weekly progress. At their home institutions, students examined optical spectra from SDSS Data Release 10 to determine if a quasar could be discerned. Both Type I and Type II quasars can be seen in the SDSS data. Seven teams of students from different schools compared their findings and collaborated online to discuss potential discoveries. This project can serve as a model for high school teachers who want to facilitate their students participating in an authentic research project. The keys to a successful project are working with a mentor who can guide the group through difficult concepts and communicating frequently throughout the project.

  17. ORGANIZATIONAL AMBIDEXTERITY AND COMPETITIVE ADVANTAGE: TOWARD A RESEARCH MODEL

    Directory of Open Access Journals (Sweden)

    Gheorghe PREDA

    2014-06-01

    Full Text Available Ambidextrous organizations have the ability to compete in mature markets and to develop new products and services for emerging markets simultaneously. Competing in mature markets involves cost reduction, increase ofthe efficiency andthe adoption of incremental innovations that are exploitative in their nature. The development of radical new products and services for emerging markets can be achieved through exploratory innovation. The high levels of exploratory and exploitative innovation simultaneously within the same organization can lead to competitive advantage. In this paper, we present the hypotheses of research model to be tested in a future empirical study focused on the link between the capability of ambidextrous organization and their competitive advantage. Based on innovation and competitive advantage theories, we expect that exploratory innovation and exploitative innovation capabilities will sustain the competitive advantage of the organization.

  18. Research

    African Journals Online (AJOL)

    understood in the profession, evolved from therapeutic activity (within a medi- cal model ... facilitate students' ability to examine institutional systems that hinder ..... don't have connections with each other … we went to the schools and were told ... for change or conduct action research projects that deal with occupational.

  19. Research

    African Journals Online (AJOL)

    raoul

    2011-08-25

    Aug 25, 2011 ... completely replaced animals with computer modeling, manikins and ... distribution, and reproduction in any medium, provided the original ... developed internal guidelines on the use of animals in research in 2004 [13]. ... Only one institution used human cell cultures as a replacement to live animal use.

  20. Cancer genomics object model: an object model for multiple functional genomics data for cancer research.

    Science.gov (United States)

    Park, Yu Rang; Lee, Hye Won; Cho, Sung Bum; Kim, Ju Han

    2007-01-01

    The development of functional genomics including transcriptomics, proteomics and metabolomics allow us to monitor a large number of key cellular pathways simultaneously. Several technology-specific data models have been introduced for the representation of functional genomics experimental data, including the MicroArray Gene Expression-Object Model (MAGE-OM), the Proteomics Experiment Data Repository (PEDRo), and the Tissue MicroArray-Object Model (TMA-OM). Despite the increasing number of cancer studies using multiple functional genomics technologies, there is still no integrated data model for multiple functional genomics experimental and clinical data. We propose an object-oriented data model for cancer genomics research, Cancer Genomics Object Model (CaGe-OM). We reference four data models: Functional Genomic-Object Model, MAGE-OM, TMAOM and PEDRo. The clinical and histopathological information models are created by analyzing cancer management workflow and referencing the College of American Pathology Cancer Protocols and National Cancer Institute Common Data Elements. The CaGe-OM provides a comprehensive data model for integrated storage and analysis of clinical and multiple functional genomics data.

  1. Nuclear model calculations and their role in space radiation research

    Science.gov (United States)

    Townsend, L. W.; Cucinotta, F. A.; Heilbronn, L. H.

    2002-01-01

    Proper assessments of spacecraft shielding requirements and concomitant estimates of risk to spacecraft crews from energetic space radiation requires accurate, quantitative methods of characterizing the compositional changes in these radiation fields as they pass through thick absorbers. These quantitative methods are also needed for characterizing accelerator beams used in space radiobiology studies. Because of the impracticality/impossibility of measuring these altered radiation fields inside critical internal body organs of biological test specimens and humans, computational methods rather than direct measurements must be used. Since composition changes in the fields arise from nuclear interaction processes (elastic, inelastic and breakup), knowledge of the appropriate cross sections and spectra must be available. Experiments alone cannot provide the necessary cross section and secondary particle (neutron and charged particle) spectral data because of the large number of nuclear species and wide range of energies involved in space radiation research. Hence, nuclear models are needed. In this paper current methods of predicting total and absorption cross sections and secondary particle (neutrons and ions) yields and spectra for space radiation protection analyses are reviewed. Model shortcomings are discussed and future needs presented. c2002 COSPAR. Published by Elsevier Science Ltd. All right reserved.

  2. Rodent models in neuroscience research: is it a rat race?

    Directory of Open Access Journals (Sweden)

    Bart Ellenbroek

    2016-10-01

    Full Text Available Rodents (especially Mus musculus and Rattus norvegicus have been the most widely used models in biomedical research for many years. A notable shift has taken place over the last two decades, with mice taking a more and more prominent role in biomedical science compared to rats. This shift was primarily instigated by the availability of a much larger genetic toolbox for mice, particularly embryonic-stem-cell-based targeting technology for gene disruption. With the recent emergence of tools for altering the rat genome, notably genome-editing technologies, the technological gap between the two organisms is closing, and it is becoming more important to consider the physiological, anatomical, biochemical and pharmacological differences between rats and mice when choosing the right model system for a specific biological question. The aim of this short review and accompanying poster is to highlight some of the most important differences, and to discuss their impact on studies of human diseases, with a special focus on neuropsychiatric disorders.

  3. Using the QUAIT Model to Effectively Teach Research Methods Curriculum to Master's-Level Students

    Science.gov (United States)

    Hamilton, Nancy J.; Gitchel, Dent

    2017-01-01

    Purpose: To apply Slavin's model of effective instruction to teaching research methods to master's-level students. Methods: Barriers to the scientist-practitioner model (student research experience, confidence, and utility value pertaining to research methods as well as faculty research and pedagogical incompetencies) are discussed. Results: The…

  4. Enhancing Hydrologic Modelling in the Coupled Weather Research and Forecasting-Urban Modelling System

    Science.gov (United States)

    Yang, Jiachuan; Wang, Zhi-Hua; Chen, Fei; Miao, Shiguang; Tewari, Mukul; Voogt, James A.; Myint, Soe

    2015-04-01

    Urbanization modifies surface energy and water budgets, and has significant impacts on local and regional hydroclimate. In recent decades, a number of urban canopy models have been developed and implemented into the Weather Research and Forecasting (WRF) model to capture urban land-surface processes. Most of these models are inadequate due to the lack of realistic representation of urban hydrological processes. Here, we implement physically-based parametrizations of urban hydrological processes into the single layer urban canopy model in the WRF model. The new single-layer urban canopy model features the integration of, (1) anthropogenic latent heat, (2) urban irrigation, (3) evaporation from paved surfaces, and (4) the urban oasis effect. The new WRF-urban modelling system is evaluated against field measurements for four different cities; results show that the model performance is substantially improved as compared to the current schemes, especially for latent heat flux. In particular, to evaluate the performance of green roofs as an urban heat island mitigation strategy, we integrate in the urban canopy model a multilayer green roof system, enabled by the physical urban hydrological schemes. Simulations show that green roofs are capable of reducing surface temperature and sensible heat flux as well as enhancing building energy efficiency.

  5. Sample Size Considerations in Prevention Research Applications of Multilevel Modeling and Structural Equation Modeling.

    Science.gov (United States)

    Hoyle, Rick H; Gottfredson, Nisha C

    2015-10-01

    When the goal of prevention research is to capture in statistical models some measure of the dynamic complexity in structures and processes implicated in problem behavior and its prevention, approaches such as multilevel modeling (MLM) and structural equation modeling (SEM) are indicated. Yet the assumptions that must be satisfied if these approaches are to be used responsibly raise concerns regarding their use in prevention research involving smaller samples. In this article, we discuss in nontechnical terms the role of sample size in MLM and SEM and present findings from the latest simulation work on the performance of each approach at sample sizes typical of prevention research. For each statistical approach, we draw from extant simulation studies to establish lower bounds for sample size (e.g., MLM can be applied with as few as ten groups comprising ten members with normally distributed data, restricted maximum likelihood estimation, and a focus on fixed effects; sample sizes as small as N = 50 can produce reliable SEM results with normally distributed data and at least three reliable indicators per factor) and suggest strategies for making the best use of the modeling approach when N is near the lower bound.

  6. The use of animal models in behavioural neuroscience research.

    Science.gov (United States)

    Bovenkerk, Bernice; Kaldewaij, Frederike

    2015-01-01

    Animal models are used in experiments in the behavioural neurosciences that aim to contribute to the prevention and treatment of cognitive and affective disorders in human beings, such as anxiety and depression. Ironically, those animals that are likely to be the best models for psychopathology are also likely to be considered the ones that are most morally problematic to use, if it seems probable that (and if indeed they are initially selected as models because) they have experiences that are similar to human experiences that we have strong reasons to avoid causing, and indeed aim to alleviate (such as pain, anxiety or sadness). In this paper, against the background of contemporary discussions in animal ethics and the philosophy of animal minds, we discuss the views that it is morally permissible to use animals in these kinds of experiments, and that it is better to use less cognitively complex animals (such as zebrafish) than more complex animals (such as dogs). First, we criticise some justifications for the claim that human beings and more complex animals have higher moral status. We argue that contemporary approaches that attribute equal moral status to all beings that are capable of conscious strivings strivings (e.g. avoiding pain and anxiety; aiming to eat and play) are based on more plausible assumptions. Second, we argue that it is problematic to assume that less cognitively complex animals have a lesser sensory and emotional experience than more complex beings across the board. In specific cases, there might be good reasons to assume that more complex beings would be harmed more by a specific physical or environmental intervention, but it might also be that they sometimes are harmed less because of a better ability to cope. Determining whether a specific experiment is justified is therefore a complex issue. Our aim in this chapter is to stimulate further reflection on these common assumptions behind the use of animal models for psychopathologies. In

  7. The Capra Research Program for Modelling Extreme Mass Ratio Inspirals

    Science.gov (United States)

    Thornburg, Jonathan

    2011-02-01

    Suppose a small compact object (black hole or neutron star) of mass m orbits a large black hole of mass M ≫ m. This system emits gravitational waves (GWs) that have a radiation-reaction effect on the particle's motion. EMRIs (extreme-mass-ratio inspirals) of this type will be important GW sources for LISA. To fully analyze these GWs, and to detect weaker sources also present in the LISA data stream, will require highly accurate EMRI GW templates. In this article I outline the ``Capra'' research program to try to model EMRIs and calculate their GWs ab initio, assuming only that m ≪ M and that the Einstein equations hold. Because m ≪ M the timescale for the particle's orbit to shrink is too long for a practical direct numerical integration of the Einstein equations, and because this orbit may be deep in the large black hole's strong-field region, a post-Newtonian approximation would be inaccurate. Instead, we treat the EMRI spacetime as a perturbation of the large black hole's ``background'' (Schwarzschild or Kerr) spacetime and use the methods of black-hole perturbation theory, expanding in the small parameter m/M. The particle's motion can be described either as the result of a radiation-reaction ``self-force'' acting in the background spacetime or as geodesic motion in a perturbed spacetime. Several different lines of reasoning lead to the (same) basic O(m/M) ``MiSaTaQuWa'' equations of motion for the particle. In particular, the MiSaTaQuWa equations can be derived by modelling the particle as either a point particle or a small Schwarzschild black hole. The latter is conceptually elegant, but the former is technically much simpler and (surprisingly for a nonlinear field theory such as general relativity) still yields correct results. Modelling the small body as a point particle, its own field is singular along the particle worldline, so it's difficult to formulate a meaningful ``perturbation'' theory or equations of motion there. Detweiler and Whiting found

  8. Toward a Conceptual Model of Mentoring Research: Integration with Self-Regulated Learning

    Science.gov (United States)

    Schunk, Dale H.; Mullen, Carol A.

    2013-01-01

    In this article, we present a model for academic mentoring research that incorporates theory and research on self-regulated learning. Academic mentoring research has increased in recent years, and researchers have linked mentoring with positive outcomes for protégés and mentors. This research, however, has not investigated the process whereby…

  9. Design-Based Implementation Research: An Emerging Model for Transforming the Relationship of Research and Practice

    Science.gov (United States)

    Fishman, Barry J.; Penuel, William R.; Allen, Anna-Ruth; Cheng, Britte Haugan; Sabelli, Nora

    2013-01-01

    This chapter presents an introduction to design-based implementation research (DBIR). We describe the need for DBIR as a research approach that challenges educational researchers and practitioners to transcend traditional research/practice barriers to facilitate the design of educational interventions that are effective, sustainable, and scalable.…

  10. International Combined Orthopaedic Research Societies: A model for international collaboration to promote orthopaedic and musculoskeletal research

    Directory of Open Access Journals (Sweden)

    Theodore Miclau

    2014-10-01

    Full Text Available In October 2013, the International Combined Orthopaedic Research Societies (ICORS; http://i-cors.org was founded with inaugural member organisations from the previous Combined Orthopaedic Research Society, which had sponsored combined meetings for more than 2 decades. The ICORS is dedicated to the stimulation of orthopaedic and musculoskeletal research in fields such as biomedical engineering, biology, chemistry, and veterinary and human clinical research. The ICORS seeks to facilitate communication with member organisations to enhance international research collaborations and to promote the development of new international orthopaedic and musculoskeletal research organisations. Through new categories of membership, the ICORS represents the broadest coalition of orthopaedic research organisations globally.

  11. Conceptual Frameworks and Research Models on Resilience in Leadership

    Directory of Open Access Journals (Sweden)

    Janet Ledesma

    2014-08-01

    Full Text Available The purpose of this article was to discuss conceptual frameworks and research models on resilience theory. The constructs of resilience, the history of resilience theory, models of resilience, variables of resilience, career resilience, and organizational resilience will be examined and discussed as they relate to leadership development. The literature demonstrates that there is a direct relationship between the stress of the leader’s job and his or her ability to maintain resilience in the face of prolonged contact with adversity. This article discusses resilience theory as it relates to leadership development. The concept associated with resilience, which includes thriving and hardiness, is explored with the belief that resilient leaders are invaluable to the sustainability of an organization. In addition, the constructs of resilience and the history of resilience studies in the field of psychiatry, developmental psychopathy, human development, medicine, epidemiology, and the social sciences are examined. Survival, recovery, and thriving are concepts associated with resilience and describe the stage at which a person may be during or after facing adversity. The concept of “thriving” refers to a person’s ability to go beyond his or her original level of functioning and to grow and function despite repeated exposure to stressful experiences. The literature suggests a number of variables that characterize resilience and thriving. These variables include positive self-esteem, hardiness, strong coping skills, a sense of coherence, self-efficacy, optimism, strong social resources, adaptability, risk-taking, low fear of failure, determination, perseverance, and a high tolerance of uncertainty. These are reviewed in this article. The findings in this article suggest that those who develop leaders need to create safe environments to help emerging and existing leaders thrive as individuals and as organizational leaders in the area of resilience

  12. Research on applying the interests distribution method of enterprise-university-research institute cooperation based on hash model

    Institute of Scientific and Technical Information of China (English)

    WANG Yu-dong

    2007-01-01

    In order to get an acceptable interests-distribution scheme for each partner of enterprise-university-research institute cooperation in advance, based on Nash model, the paper designs the interest distribution method of enterprise-university-research institute cooperation and provides the basis for determining the weight of each partner in accordance with the interest distribution principles and subjected relations between major factors in enterprise-university-research institute cooperation. Also, in combination with one example, an applicable method is provided to distribute interest in enterprise-university-research institute cooperation. The study gives some references for interests-distribution of enterprise-university-research institute cooperation.

  13. "It puts a human face on the researched"--A qualitative evaluation of an Indigenous health research governance model.

    Science.gov (United States)

    Bond, Chelsea; Foley, Wendy; Askew, Deborah

    2016-04-01

    To describe the Inala Aboriginal and Torres Strait Islander Community Jury for Health Research, and evaluate its usefulness as a model of Indigenous research governance within an urban Indigenous primary health care service from the perspectives of jury members and researchers. Informed by a phenomenological approach and using narrative inquiry, a focus group was conducted with jury members and key informant interviews were undertaken with researchers who had presented to the Community Jury in its first year of operation. The jury was a site of identity work for researchers and jury members, providing an opportunity to observe and affirm community cultural protocols. Although researchers and jury members had differing levels of research literacy, the jury processes enabled respectful communication and relationships to form, which positively influenced research practice, community aspirations and clinical care. The jury processes facilitated transformative research practice among researchers and resulted in transference of power from researchers to the jury members, to the mutual benefit of both. Ethical Indigenous health research practice requires an engagement with Indigenous peoples and knowledge at the research governance level, not simply as subjects or objects of research. © 2015 The Authors.

  14. Faculty development in medical education research: a cooperative model.

    Science.gov (United States)

    Coates, Wendy C; Love, Jeffrey N; Santen, Sally A; Hobgood, Cherri D; Mavis, Brian E; Maggio, Lauren A; Farrell, Susan E

    2010-05-01

    As the definition of scholarship is clarified, each specialty should develop a cadre of medical education researchers who can design, test, and optimize educational interventions. In 2004, the Association for American Medical Colleges' Group on Educational Affairs developed the Medical Education Research Certificate (MERC) program to provide a curriculum to help medical educators acquire or enhance skills in medical education research, to promote effective collaboration with seasoned researchers, and to create better consumers of medical education scholarship. MERC courses are offered to individuals during educational meetings. Educational leaders in emergency medicine (EM) identified a disparity between the "scholarship of teaching" and medical education research skills, and they collaborated with the MERC steering committee to develop a mentored faculty development program in medical education research. A planning committee comprising experienced medical education researchers who are also board-certified, full-time EM faculty members designed a novel approach to the MERC curriculum: a mentored team approach to learning, grounded in collaborative medical education research projects. The planning committee identified areas of research interest among participants and formed working groups to collaborate on research projects during standard MERC workshops. Rather than focusing on individual questions during the course, each mentored group identified a single study hypothesis. After completing the first three workshops, group members worked under their mentors' guidance on their multiinstitutional research projects. The expected benefits of this approach to MERC include establishing a research community network, creating projects whose enrollments offer a multiinstitutional dimension, and developing a cadre of trained education researchers in EM.

  15. The Capra Research Program for Modelling Extreme Mass Ratio Inspirals

    CERN Document Server

    Thornburg, Jonathan

    2011-01-01

    Suppose a small compact object (black hole or neutron star) of mass $m$ orbits a large black hole of mass $M \\gg m$. This system emits gravitational waves (GWs) that have a radiation-reaction effect on the particle's motion. EMRIs (extreme--mass-ratio inspirals) of this type will be important GW sources for LISA; LISA's data analysis will require highly accurate EMRI GW templates. In this article I outline the "Capra" research program to try to model EMRIs and calculate their GWs \\textit{ab initio}, assuming only that $m \\ll M$ and that the Einstein equations hold. Here we treat the EMRI spacetime as a perturbation of the large black hole's "background" (Schwarzschild or Kerr) spacetime and use the methods of black-hole perturbation theory, expanding in the small parameter $m/M$. The small body's motion can be described either as the result of a radiation-reaction "self-force" acting in the background spacetime or as geodesic motion in a perturbed spacetime. Several different lines of reasoning lead to the (s...

  16. From Mice to Men: research models of developmental programming.

    Science.gov (United States)

    Rabadán-Diehl, C; Nathanielsz, P

    2013-02-01

    Developmental programming can be defined as a response to a specific challenge to the mammalian organism during a critical developmental time window that alters the trajectory of development with persistent effects on offspring phenotype and predisposition to future illness. We focus on the need for studies in relevant, well-characterized animal models in the context of recent research discoveries on the challenges, mechanisms and outcomes of developmental programming. We discuss commonalities and differences in general principles of developmental programming as they apply to several species, including humans. The consequences of these differences are discussed. Obesity, metabolic disorders and cardiovascular diseases are associated with the highest percentage of morbidity and mortality worldwide. Although many of the causes are associated with lifestyle, high-energy diets and lack of physical activity, recent evidence has linked developmental programming to the epidemic of metabolic diseases. A better understanding of comparative systems physiology of mother, fetus and neonate using information provided by rapid advances in molecular biology has the potential to improve the lifetime health of future generations by providing better women's health, diagnostic tools and preventative and therapeutic interventions in individuals exposed during their development to programming influences.

  17. Ovarian aging and menopause: current theories, hypotheses, and research models.

    Science.gov (United States)

    Wu, Julie M; Zelinski, Mary B; Ingram, Donald K; Ottinger, Mary Ann

    2005-12-01

    Aging of the reproductive system has been studied in numerous vertebrate species. Although there are wide variations in reproductive strategies and hormone cycle components, many of the fundamental changes that occur during aging are similar. Evolutionary hypotheses attempt to explain why menopause occurs, whereas cellular hypotheses attempt to explain how it occurs. It is commonly believed that a disruption in the hypothalamic-pituitary-gonadal axis is responsible for the onset of menopause. Data exist to demonstrate that the first signs of menopause occur at the level of the brain or the ovary. Thus, finding an appropriate and representative animal model is especially important for the advancement of menopause research. In primates, there is a gradual decline in the function of the hypothalamic-pituitary-gonadal (HPG) axis ultimately resulting in irregularities in menstrual cycles and increasingly sporadic incidence of ovulation. Rodents also exhibit a progressive deterioration in HPG axis function; however, they also experience a period of constant estrus accompanied by intermittent ovulations, reduced progesterone levels, and elevated circulating estradiol levels. It is remarkable to observe that females of other classes also demonstrate deterioration in HPG axis function and ovarian failure. Comparisons of aging in various taxa provide insight into fundamental biological mechanisms of aging that could underlie reproductive decline.

  18. Research in Adaptronic Automatic Control System and Biosensor System Modelling

    Directory of Open Access Journals (Sweden)

    Skopis Vladimir

    2015-07-01

    Full Text Available This paper describes the research on adaptronic systems made by the author and offers to use biosensors that can be later inserted into the adaptronic systems. Adaptronic systems are based, on the one hand, on the adaptronic approach when the system is designed not to always meet the worst condition, but to change the structure of the system according to the external conditions. On the other hand, it is an extension of common automatic control ad adaptive systems. So, in the introduction firstly the adaptronic approach and biosensor as a term is explained. Adaptive systems, upon which adaptronic ones are based, are also mentioned. Then the construction of biosensor is described, as well as some information is given about the classification of biosensors and their main groups. Also it is suggested to use lichen indicators in industry to control concentration of chemical substances in the air. After that mathematical models and computer experiments for adaptronic system and biosensor analysis are given.

  19. [HEALING MODEL RESEARCH OF ROTATOR CUFF INJURY IN CANINE].

    Science.gov (United States)

    Ye, Wei; Bao, Nirong; Zhaq, Jianning

    2016-04-01

    cuff injury healing process, so it can be used as an ideal animal model for related research.

  20. Adolescent Psychosocial Development: A Review of Longitudinal Models and Research

    Science.gov (United States)

    Meeus, Wim

    2016-01-01

    This review used 4 types of longitudinal models (descriptive models, prediction models, developmental sequence models and longitudinal mediation models) to identify regular patterns of psychosocial development in adolescence. Eight patterns of adolescent development were observed across countries: (1) adolescent maturation in multiple…

  1. Research of database-based modeling for mining management system

    Institute of Scientific and Technical Information of China (English)

    WU Hai-feng; JIN Zhi-xin; BAI Xi-jun

    2005-01-01

    Put forward the method to construct the simulation model automatically with database-based automatic modeling(DBAM) for mining system. Designed the standard simulation model linked with some open cut Pautomobile dispatch system. Analyzed and finded out the law among them, and designed model maker to realize the automatic programming of the new model program.

  2. Alternative Model of Funding for Academic Research in Nigerian Universities

    Science.gov (United States)

    Olayiwola, Shina

    2010-01-01

    Funding of academic research in Nigerian universities by Government (5 per cent recurrent grants) is a policy dictated by the National Universities Commission (NUC) as the central body for allocating research funds. This research fund, little as it is, is irregular and inadequate and to make it worse is difficult to access. These aforementioned…

  3. Defining and implementing a model for pharmacy resident research projects

    Directory of Open Access Journals (Sweden)

    Dick TB

    2015-09-01

    Full Text Available Objective: To describe a standard approach to provide a support structure for pharmacy resident research that emphasizes self-identification of a residency research project. Methods: A subcommittee of the residency advisory committee was formed at our institution. The committee was initially comprised of 2 clinical pharmacy specialists, 1 drug information pharmacist, and 2 pharmacy administrators. The committee developed research guidelines that are distributed to residents prior to the residency start that detail the research process, important deadlines, and available resources. Instructions for institutional review board (IRB training and deadlines for various assignments and presentations throughout the residency year are clearly defined. Residents conceive their own research project and emphasis is placed on completing assignments early in the residency year. Results: In the 4 years this research process has been in place, 15 of 16 (94% residents successfully identified their own research question. All 15 residents submitted a complete research protocol to the IRB by the August deadline. Four residents have presented the results of their research at multi-disciplinary national professional meetings and 1 has published a manuscript. Feedback from outgoing residents has been positive overall and their perceptions of their research projects and the process are positive. Conclusion: Pharmacy residents selecting their own research projects for their residency year is a feasible alternative to assigning or providing lists of research projects from which to select a project.

  4. Framing agenda for business model innovation research from the B2B context

    OpenAIRE

    Neupane, Ganesh Prasad; Haugland, Sven A.

    2016-01-01

    This paper reviews the literature on business models in the business-to-business (B2B) context and proposes a research agenda that can be explored by future studies using various management and organizational theories. We outline four research themes and seven research topics for research on business model innovations in the B2B context. Further studies on these topics can make significant contributions to the business model literature.

  5. Conceptual Models in Health Informatics Research: A Literature Review and Suggestions for Development

    OpenAIRE

    Gray, Kathleen; Sockolow, Paulina

    2016-01-01

    Background Contributing to health informatics research means using conceptual models that are integrative and explain the research in terms of the two broad domains of health science and information science. However, it can be hard for novice health informatics researchers to find exemplars and guidelines in working with integrative conceptual models. Objectives The aim of this paper is to support the use of integrative conceptual models in research on information and communication technologi...

  6. Research Anxiety and Students' Perceptions of Research: An Experiment. Part I. Effect of Teaching Kuhlthau's ISP Model.

    Science.gov (United States)

    Kracker, Jacqueline

    2002-01-01

    Investigates the effect of a 30-minute presentation of Carol Kuhlthau's Information Search Process (ISP) model on undergraduate students' perceptions of research and research paper anxiety, focusing on results of the quantitative analysis. Highlights include pretests and posttest results; and data analysis and hypothesis testing. (Author/LRW)

  7. Animating Research with Counseling Values: A Training Model to Address the Research-to-Practice Gap

    Science.gov (United States)

    Lee, Kristi A.; Dewell, John A.; Holmes, Courtney M.

    2014-01-01

    The persistent research-to-practice gap poses a problem for counselor education. The gap may be caused by conflicts between the humanistic values that guide much of counseling and the values that guide research training. In this article, the authors address historical concerns regarding research training for students and the conducting of research…

  8. Plants: a unique model for research on high diluted substances

    Directory of Open Access Journals (Sweden)

    Tatiana Vladimirovna Novasadyuk

    2011-09-01

    adding Coca 1000 СН remedy, and then in one month the upper part of the plant was sprayed with Echinacea 30 СН. The same amounts of similar plants of the same breeds treated according to conventional agricultural technology were used as a control group. Results: As a result earlier ripening was found in the Typhoon F1 tomato breed: it occurred by 19 days earlier: that is by 18.3% than in the control group. The Titan tomatoes group ripened by 14.3% faster than in the control one. Every plant of the Typhoon breed produced an average of 45 tomato fruits, while in the control group the average number amounted to 14 (i.e. there was an increase of 221.4% in the test group. An average of 78 tomato fruits were produced by the Titan breed plants, while in the control group this number was only 20 (increase by 290%. Mean weight of the Typhoon tomato fruit increased by 59.5 g from the control values, i.e. by 180.8%. Mean weight of the Titan tomato fruit increased by 128.5 i.e. by 208.9%. A notable difference was found by all observers in the taste of experimental and control vegetables. The experimental plants had significantly better taste characteristics and they were also more resistant to buck eye rot. Conclusion: In such a way, the studies performed confirm the existence of homeopathic phenomenon in live organisms in the absence of the placebo effect. It has been demonstrated that the use of homeopathic remedies is effective in improvement of agricultural productivity. Plants are unique model for research of ultrahigh dilutions of substances.

  9. HMF-Geophysics: A Model for Collaborative Research in Hydrogeophysics

    Science.gov (United States)

    Knight, R.; Crook, N.; Bales, R.; Moore, J.; Papanicolaou, T.; Welty, C.

    2008-05-01

    CUAHSI is developing, with the support of the NSF, a Hydrologic Measurement Facility (HMF). HMF-Geophysics is the near-surface geophysics module of HMF. Over the three years of the NSF grant (2005-08) we will determine, through broad community consultation, how best to utilize geophysical instrumentation and engage geophysical expertise in addressing key challenges in the hydrologic sciences. Our goal is to put in place the infrastructure needed to develop and maintain partnerships between the hydrologic and geophysical communities so that geophysical methods are used in a way that represents the state-of-the-science. Our current model consists of a central "node" that conducts feasibility studies to determine how/if geophysical methods could be of use in a hydrologic research project. In addition to the central node we have developed a system of affiliated nodes, individuals at 14 institutions who have committed to support HMF-Geophysics activities by offering equipment, software, and expertise. Once a feasibility study has shown the value of geophysics at a particular site, we match the hydrology PI with one of the nodes to develop the full-scale research project. We have conducted feasibility studies at 6 sites: Reynolds Creek Watershed, the H.J. Andrews Experimental Forest, and four WATERS test- beds, the latter are described below. The objective of the Baltimore test-bed is to quantify the urban water cycle, with an emphasis on groundwater, using the Gwynns Falls watershed as a pilot study area. Electrical resistivity imaging, ground penetrating radar, and seismic refraction were assessed as a means of determining depth to bedrock or to the water table within the riparian zone of urbanized streams. A regional time-lapse microgravity survey was conducted at the 200 sq- km watershed scale to infer the storage change in the underlying aquifers. Research in the Crown of the Continent test-bed in Montana is focused on understanding the interactions between the

  10. Model-Driven Software Evolution: A Research Agenda

    NARCIS (Netherlands)

    Van Deursen, A.; Visser, E.; Warmer, J.

    2007-01-01

    Software systems need to evolve, and systems built using model-driven approaches are no exception. What complicates model-driven engineering is that it requires multiple dimensions of evolution. In regular evolution, the modeling language is used to make the changes. In meta-model evolution, changes

  11. A partnership model for a reflective narrative for researcher and participant.

    Science.gov (United States)

    Murphy, Gill; Peters, Kath; Wilkes, Lesley; Jackson, Debra

    2016-09-01

    Background Conceptual frameworks are important to ensure a clear underpinning research philosophy. Further, the use of conceptual frameworks can support structured research processes. Aim To present a partnership model for a reflective narrative for researcher and participant. Discussion This paper positions the underpinning philosophical framework of the model in social constructionism (the idea that jointly constructed understandings form the basis for shared assumptions) and narrative enquiry. The model has five stages - study design, invitation to share a research space and partnership, a metaphorical research space, building a community story, and reading the community story to others. Core principles of the partnership model are continual reflection by the researcher, potential reflections by participants, reciprocal sharing, and partnership in research. Conclusion A 'trajectory of self' for both participants and researchers can be enhanced within reflective partnerships. Implications for practice This model can be applied to studies that use narrative enquiry and are seeking a humanistic approach with participant engagement.

  12. Review of Research on Teacher Communication Styles with Use of the Leary Model.

    Science.gov (United States)

    Wubbels, Theo; And Others

    1992-01-01

    A 1957 book by Timothy Leary presented a model for interpersonal behavior. Dutch researchers have worked on using the model in educational research and teacher education. The paper discusses results of a research program which studied student and teacher perceptions of interpersonal behavior, teacher communication styles, and student outcomes. (SM)

  13. Review of Research on Teacher Communication Styles with Use of the Leary Model.

    Science.gov (United States)

    Wubbels, Theo; And Others

    1992-01-01

    A 1957 book by Timothy Leary presented a model for interpersonal behavior. Dutch researchers have worked on using the model in educational research and teacher education. The paper discusses results of a research program which studied student and teacher perceptions of interpersonal behavior, teacher communication styles, and student outcomes. (SM)

  14. Soil process modelling in CZO research: gains in data harmonisation and model validation

    Science.gov (United States)

    van Gaans, Pauline; Andrianaki, Maria; Kobierska, Florian; Kram, Pavel; Lamacova, Anna; Lair, Georg; Nikolaidis, Nikos; Duffy, Chris; Regelink, Inge; van Leeuwen, Jeroen P.; de Ruiter, Peter

    2014-05-01

    Various soil process models were applied to four European Critical Zone observatories (CZOs), the core research sites of the FP7 project SoilTrEC: the Damma glacier forefield (CH), a set of three forested catchments on geochemically contrasing bedrocks in the Slavkov Forest (CZ), a chronosequence of soils in the former floodplain of the Danube of Fuchsenbigl/Marchfeld (AT), and the Koiliaris catchments in the north-western part of Crete, (GR). The aim of the modelling exercises was to apply and test soil process models with data from the CZOs for calibration/validation, identify potential limits to the application scope of the models, interpret soil state and soil functions at key stages of the soil life cycle, represented by the four SoilTrEC CZOs, contribute towards harmonisation of data and data acquisition. The models identified as specifically relevant were: The Penn State Integrated Hydrologic Model (PIHM), a fully coupled, multiprocess, multi-scale hydrologic model, to get a better understanding of water flow and pathways, The Soil and Water Assessment Tool (SWAT), a deterministic, continuous time (daily time step) basin scale model, to evaluate the impact of soil management practices, The Rothamsted Carbon model (Roth-C) to simulate organic carbon turnover and the Carbon, Aggregation, and Structure Turnover (CAST) model to include the role of soil aggregates in carbon dynamics, The Ligand Charge Distribution (LCD) model, to understand the interaction between organic matter and oxide surfaces in soil aggregate formation, and The Terrestrial Ecology Model (TEM) to obtain insight into the link between foodweb structure and carbon and nutrient turnover. With some exceptions all models were applied to all four CZOs. The need for specific model input contributed largely to data harmonisation. The comparisons between the CZOs turned out to be of great value for understanding the strength and limitations of the models, as well as the differences in soil conditions

  15. Towards a model for research-based exhibition development using design-based research as a framework

    DEFF Research Database (Denmark)

    Zachariassen, Maria; Magnussen, Rikke; Thiel Sandholdt, Cathrina

    2016-01-01

    practices. A research-based approach can expand understanding of exhibitions as a media, encouraging a more systematised, theory-based and documented practice. This premise forms the basis for creating a model for collaboration between research and exhibition development in a science centre context......This paper argues that a higher level of research activity is necessary at all levels in the creation of science centre exhibitions. Science centres focus greatly on their role as an informal learning space but rarely integrate learning theories or develop documented knowledge in their exhibition...... that facilitates an iterative research-based development process and that emphasises focusing on learning elements. We present a new model for developing research-based exhibitions and provide an accompanying analysis based on PULSE, a four-year project involving the development of a health promotion exhibition...

  16. Structural equation modeling: Possibilities for language learning researchers

    NARCIS (Netherlands)

    Hancock, G.R.; Schoonen, R.

    2015-01-01

    Although classical statistical techniques have been a valuable tool in second language (L2) research, L2 research questions have started to grow beyond those techniques’ capabilities, and indeed are often limited by them. Questions about how complex constructs relate to each other or to constituent

  17. Research Models of the Future for Industrial and Organizational Psychology.

    Science.gov (United States)

    Barrett, Gerald V.

    This paper presents three different aspects of research in industrial and organizational psychology. First, characteristics of major advances in science, and in the social and behavioral sciences are given, including: (1) team research is more common for major advances; and (2) young men under 35 are responsible for many major contributions.…

  18. Forging a 21st Century Model for Undergraduate Research

    Science.gov (United States)

    Musante, Susan

    2011-01-01

    Not all biology students get to experience scientific research firsthand, but the National Genomics Research Initiative (NGRI) is working to change that. The NGRI is the first initiative to spring from Howard Hughes Medical Institute's (HHMI) new Science Education Alliance (SEA). At present, a competitive application process determines which…

  19. Modelling in cross-disciplinary authentic student research projects

    NARCIS (Netherlands)

    A. Heck

    2010-01-01

    In the Dutch secondary education system, students must carry out at the end of their school career a rather large research or design project to demonstrate their ability to apply acquired knowledge and skills while pursuing a research question or design goal in some depth. They are encouraged to cho

  20. The Reflective Teacher Leader: An Action Research Model

    Science.gov (United States)

    Furtado, Leena; Anderson, Dawnette

    2012-01-01

    This study presents four teacher reflections from action research projects ranging from kindergarten to adult school improvements. A teacher leadership matrix guided participants to connect teaching and learning theory to best practices by exploring uncharted territory within an iterative cycle of research and action. Teachers developed the…

  1. Structural Equation Modeling: Possibilities for Language Learning Researchers

    Science.gov (United States)

    Hancock, Gregory R.; Schoonen, Rob

    2015-01-01

    Although classical statistical techniques have been a valuable tool in second language (L2) research, L2 research questions have started to grow beyond those techniques' capabilities, and indeed are often limited by them. Questions about how complex constructs relate to each other or to constituent subskills, about longitudinal development in…

  2. Integrating teacher education effectiveness research into educational effectiveness models

    NARCIS (Netherlands)

    Scheerens, Jaap; Blömeke, Sigrid

    2016-01-01

    The purpose of this article is to review and to connect research about teacher education effectiveness and school effectiveness to arrive at an integrative conceptualization that has the potential of improving empirical research in both fields. Teacher education effectiveness addresses effects of te

  3. Integrating teacher education effectiveness research into educational effectiveness models

    NARCIS (Netherlands)

    Scheerens, Jaap; Blömeke, Sigrid

    2016-01-01

    The purpose of this article is to review and to connect research about teacher education effectiveness and school effectiveness to arrive at an integrative conceptualization that has the potential of improving empirical research in both fields. Teacher education effectiveness addresses effects of

  4. Attitude Research in Science Education: Contemporary Models and Methods.

    Science.gov (United States)

    Crawley, Frank E.; Koballa, Thomas R., Jr.

    Social interaction and influence have been the subject of considerable research. Examining in great detail the factors involved in social influence has enabled social psychologists to understand better the effects of persuasion, propaganda, coercion, indoctrination, and brainwashing. Out of this research has come a widespread acceptance of the…

  5. Modeling Scientific Research Articles – Shifting Perspectives and Persistent Issues

    NARCIS (Netherlands)

    De Waard, Anita; Kircz, Joost

    2008-01-01

    We review over 10 years of research at Elsevier and various Dutch academic institutions on establishing a new format for the scientific research article. Our work rests on two main theoretical principles: the concept of modular documents, consisting of content elements that can exist and be publishe

  6. Implementation of a new aerosol HAM model within the Weather Research and Forecasting (WRF modeling system

    Directory of Open Access Journals (Sweden)

    R. Mashayekhi

    2009-07-01

    Full Text Available A new coupled system of aerosol HAM model and the Weather, Research and Forecasting (WRF model is presented in this paper. Unlike the current aerosol schemes used in WRF model, the HAM is using a "pseudomodal" approach for the representation of the particle size distribution. The aerosol components considered are sulfate, black carbon, particulate organic matter, sea salt and mineral dust. The preliminary model results are presented for two different 6-day simulation periods from 22 to 28 February 2006 as a winter period and 6 to 12 May 2006 as a mild period. The mean shortwave radiation and thermal forcing were calculated from the model simulations with and without aerosols feedback for two simulation periods. A negative radiative forcing and cooling of the atmosphere were found mainly over the regions of high emission of mineral dust. The absorption of shortwave radiation by black carbon caused warming effects in some regions with positive radiative forcing. The simulated daily mean sulfate mass concentration showed a rather good agreement with the measurements in the European EMEP network. The diurnal variation of the simulated hourly PM10 mass concentration at Tehran was also qualitatively close to the observations in both simulation periods. The model captured diurnal cycle and the magnitude of the observed PM10 concentration during most of the simulation periods. The differences between the observed and simulated PM10 concentration resulted mostly from limitation of the model in simulating the clouds and precipitation, transport errors and uncertainties in the particulate emission rates. The inclusion of aerosols feedback in shortwave radiation scheme improved the simulated daily mean shortwave radiation fluxes in Tehran for both simulation periods.

  7. Economic modeling and energy policy planning. [technology transfer, market research

    Science.gov (United States)

    Thompson, R. G.; Schwartz, A., Jr.; Lievano, R. J.; Stone, J. C.

    1974-01-01

    A structural economic model is presented for estimating the demand functions for natural gas and crude oil in industry and in steam electric power generation. Extensions of the model to other commodities are indicated.

  8. A Scientist-Practitioner Model of Psychological Assessment: Implications for Training, Practice and Research.

    Science.gov (United States)

    Spengler, Paul M.; And Others

    1995-01-01

    Proposes a prototypical model for psychological assessment that reformulates a model of the counselor-as-scientist. Integrates the model's theory and research on human inference, judgment, and decision making; research on threats to accurate clinical prediction; and findings about counselor characteristics associated with effective judgment…

  9. The Best Practice Unit: a model for learning, research and development

    NARCIS (Netherlands)

    Wilken, Jean Pierre; Slagmaat, Carla van; Gijzel, Sascha van

    2013-01-01

    The Best Practice Unit (BPU) model constitutes a unique form of practice-based research. A variant of the Community of Practice model developed by Wenger, McDermott and Snyder (2002), the BPU has the specific aim of improving professional practice by combining innovation and research. The model is u

  10. The Best Practice Unit: a model for learning, research and development

    NARCIS (Netherlands)

    dr Jean Pierre Wilken; Carla van Slagmaat; Msc Sascha van Gijzel

    2013-01-01

    The Best Practice Unit (BPU) model constitutes a unique form of practice-based research. A variant of the Community of Practice model developed by Wenger, McDermott and Snyder (2002), the BPU has the specific aim of improving professional practice by combining innovation and research. The model is

  11. MODEL ORGANISMS USED IN MOLECULAR BIOLOGY OR MEDICAL RESEARCH

    OpenAIRE

    Pandey Govind

    2011-01-01

    A model organism is a non-human species that is studied to understand specific biological phenomena with the expectation that investigations made in the organism model will provide insight into the workings of other organisms. The model organisms are widely used to explore potential causes and treatments for human as well as animal diseases when experiments on animals or humans would be unfeasible or considered less ethical. Studying model organisms may be informative, but care must be taken ...

  12. Research on Modeling of Hydropneumatic Suspension Based on Fractional Order

    OpenAIRE

    Junwei Zhang; Sizhong Chen; Yuzhuang Zhao; Jianbo Feng; Chang Liu; Ying Fan

    2015-01-01

    With such excellent performance as nonlinear stiffness, adjustable vehicle height, and good vibration resistance, hydropneumatic suspension (HS) has been more and more applied to heavy vehicle and engineering vehicle. Traditional modeling methods are still confined to simple models without taking many factors into consideration. A hydropneumatic suspension model based on fractional order (HSM-FO) is built with the advantage of fractional order (FO) in viscoelastic material modeling considerin...

  13. Hierarchical Data Structures, Institutional Research, and Multilevel Modeling

    Science.gov (United States)

    O'Connell, Ann A.; Reed, Sandra J.

    2012-01-01

    Multilevel modeling (MLM), also referred to as hierarchical linear modeling (HLM) or mixed models, provides a powerful analytical framework through which to study colleges and universities and their impact on students. Due to the natural hierarchical structure of data obtained from students or faculty in colleges and universities, MLM offers many…

  14. Land use change modelling: current practice and research priorities

    NARCIS (Netherlands)

    Verburg, P.H.; Schot, P.; Dijst, M.J.; Veldkamp, A.

    2004-01-01

    Land use change models are tools to support the analysis of the causes and consequences of land use dynamics. Scenario analysis with land use models can support land use planning and policy. Numerous land use models are available, developed from different disciplinary backgrounds. This paper reviews

  15. The marketing model of research: structure and logic

    OpenAIRE

    Viktoriya Timonina; Dmitrii Mazanenko

    2016-01-01

    In this article the authors examine the features of the preparation and use of the marketing model of scientific and technological innovation to achieve the objectives of its economic feasibility and commercialization. The basic advantages of marketing model, as well as the example of the authors conducted technical studies are given options of graphic presentation and content marketing model of scientific and technical work.

  16. Managing postgraduate research service quality: Developing and assessing a conceptual model

    National Research Council Canada - National Science Library

    Shawn Ramroop; Krishna Kistan Govender

    2013-01-01

    ...) research service quality management model, through conducting an electronic survey among a cohort of master's and doctorate graduates at one of the top three research universities in South Africa...

  17. Zebrafish: A Versatile Animal Model for Fertility Research

    Directory of Open Access Journals (Sweden)

    Jing Ying Hoo

    2016-01-01

    Full Text Available The utilization of zebrafish in biomedical research is very common in the research world nowadays. Today, it has emerged as a favored vertebrate organism for the research in science of reproduction. There is a significant growth in amount numbers of scientific literature pertaining to research discoveries in reproductive sciences in zebrafish. It has implied the importance of zebrafish in this particular field of research. In essence, the current available literature has covered from the very specific brain region or neurons of zebrafish, which are responsible for reproductive regulation, until the gonadal level of the animal. The discoveries and findings have proven that this small animal is sharing a very close/similar reproductive system with mammals. More interestingly, the behavioral characteristics and along with the establishment of animal courtship behavior categorization in zebrafish have laid an even stronger foundation and firmer reason on the suitability of zebrafish utilization in research of reproductive sciences. In view of the immense importance of this small animal for the development of reproductive sciences, this review aimed at compiling and describing the proximate close similarity of reproductive regulation on zebrafish and human along with factors contributing to the infertility, showing its versatility and its potential usage for fertility research.

  18. Zebrafish: A Versatile Animal Model for Fertility Research

    Science.gov (United States)

    Hoo, Jing Ying; Kumari, Yatinesh; Shaikh, Mohd Farooq; Hue, Seow Mun

    2016-01-01

    The utilization of zebrafish in biomedical research is very common in the research world nowadays. Today, it has emerged as a favored vertebrate organism for the research in science of reproduction. There is a significant growth in amount numbers of scientific literature pertaining to research discoveries in reproductive sciences in zebrafish. It has implied the importance of zebrafish in this particular field of research. In essence, the current available literature has covered from the very specific brain region or neurons of zebrafish, which are responsible for reproductive regulation, until the gonadal level of the animal. The discoveries and findings have proven that this small animal is sharing a very close/similar reproductive system with mammals. More interestingly, the behavioral characteristics and along with the establishment of animal courtship behavior categorization in zebrafish have laid an even stronger foundation and firmer reason on the suitability of zebrafish utilization in research of reproductive sciences. In view of the immense importance of this small animal for the development of reproductive sciences, this review aimed at compiling and describing the proximate close similarity of reproductive regulation on zebrafish and human along with factors contributing to the infertility, showing its versatility and its potential usage for fertility research. PMID:27556045

  19. Enhancing Cloud Radiative Processes and Radiation Efficiency in the Advanced Research Weather Research and Forecasting (WRF) Model

    Energy Technology Data Exchange (ETDEWEB)

    Iacono, Michael J. [Atmospheric and Environmental Research, Lexington, MA (United States)

    2015-03-09

    The objective of this research has been to evaluate and implement enhancements to the computational performance of the RRTMG radiative transfer option in the Advanced Research version of the Weather Research and Forecasting (WRF) model. Efficiency is as essential as accuracy for effective numerical weather prediction, and radiative transfer is a relatively time-consuming component of dynamical models, taking up to 30-50 percent of the total model simulation time. To address this concern, this research has implemented and tested a version of RRTMG that utilizes graphics processing unit (GPU) technology (hereinafter RRTMGPU) to greatly improve its computational performance; thereby permitting either more frequent simulation of radiative effects or other model enhancements. During the early stages of this project the development of RRTMGPU was completed at AER under separate NASA funding to accelerate the code for use in the Goddard Space Flight Center (GSFC) Goddard Earth Observing System GEOS-5 global model. It should be noted that this final report describes results related to the funded portion of the originally proposed work concerning the acceleration of RRTMG with GPUs in WRF. As a k-distribution model, RRTMG is especially well suited to this modification due to its relatively large internal pseudo-spectral (g-point) dimension that, when combined with the horizontal grid vector in the dynamical model, can take great advantage of the GPU capability. Thorough testing under several model configurations has been performed to ensure that RRTMGPU improves WRF model run time while having no significant impact on calculated radiative fluxes and heating rates or on dynamical model fields relative to the RRTMG radiation. The RRTMGPU codes have been provided to NCAR for possible application to the next public release of the WRF forecast model.

  20. Research on Bayesian Network Based User's Interest Model

    Institute of Scientific and Technical Information of China (English)

    ZHANG Weifeng; XU Baowen; CUI Zifeng; XU Lei

    2007-01-01

    It has very realistic significance for improving the quality of users' accessing information to filter and selectively retrieve the large number of information on the Internet. On the basis of analyzing the existing users' interest models and some basic questions of users' interest (representation, derivation and identification of users' interest), a Bayesian network based users' interest model is given. In this model, the users' interest reduction algorithm based on Markov Blanket model is used to reduce the interest noise, and then users' interested and not interested documents are used to train the Bayesian network. Compared to the simple model, this model has the following advantages like small space requirements, simple reasoning method and high recognition rate. The experiment result shows this model can more appropriately reflect the user's interest, and has higher performance and good usability.

  1. Improving Weather Research and Forecasting Model Initial Conditions via Surface Pressure Analysis

    Science.gov (United States)

    2015-09-01

    Obsgrid) that creates input data for the Advanced Research version of the Weather Research and Forecasting model (WRF-ARW) is modified to perform a...Configuration  The Advanced Research version of the Weather Research and Forecasting model (WRF-ARW) V3.6.1 (Skamarock et al. 2008) is applied with 56 vertical...those with more benign weather. On 7 February a trough moved onshore and led to widespread precipitation in the region . More quiescent weather was in

  2. The research in climate system modeling, simulating and forecasting

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ The major point of the World Climate Research Program (WCRP) is to predict the real-time climate change in seasons and years. Climate disasters in China occurred frequently, and resulted in a 200 billion RMB lost annually.

  3. Applied structural equation modelling for researchers and practitioners using R and Stata for behavioural research

    CERN Document Server

    Ramlall, Indranarain

    2016-01-01

    This book explains in a rigorous, concise and practical manner all the vital components embedded in structural equation modelling. Focusing on R and stata to implement and perform various structural equation models.

  4. RESEARCH ON CAPP/SCHEDULING INTEGRATION MULTI-AGENT SYSTEM MODEL AND IMPLEMENTATION

    Institute of Scientific and Technical Information of China (English)

    Wang Yunli; Xiao Tianyuan; Duan Guanghong; Wang Xiankui

    2003-01-01

    A design methodology for multi-agent systems is proposed. The systemic framework of CAPP and scheduling integrated multi-agent system according to design methodology is researched.Agent model, composition model and cooperation model are discussed respectively in the multi-agent system. Static composition model and dynamic running model of CAPP and scheduling integrated system are presented in composition model. Communication model, language model and protocol model are discussed in corporation model. CSIMAS, CAPP and scheduling integrated multi-agent prototype system, is developed to illuminate system model. Multiple non-rotational parts are tested in distributed process planning and scheduling environment of CSIMAS.

  5. Twenty years of experience with the rabbit model, a versatile model for tracheal transplantation research

    Institute of Scientific and Technical Information of China (English)

    Margot Den Hondt; Bart M Vanaudenaerde; Pierre Delaere; Jan J Vranckx

    2016-01-01

    Pathologies comprising more than half the length of the trachea are a challenge to the reconstructive surgeon. Innovative tracheal transplantation techniques aim to offer the patient a curative solution with a sustained improvement in quality of life. This review summarizes the authors’ experience with the rabbit as a versatile model for research regarding tracheal transplantation. Because of the segmental blood supply of the trachea, it is not feasible to transplant the organ together with a well-defined vascular pedicle. As such, the key element of successful tracheal transplantation is the creation of a new blood supply. This vascularized construct is created by prelaminating the rabbit trachea heterotopically, within the lateral thoracic fascia. After prelamination, the construct and its vascular pedicle are transferred to the orthotopic position in the neck. This model has become gold standard because of the advantages of working with rabbits, the anatomy of the rabbit trachea, and the reliability of the lateral thoracic artery flap. In this paper, the key elements of surgery in the rabbit are discussed, as well as the tracheal anastomosis and the harvest of the lateral thoracic artery flap. Practical tips and tricks are presented. The data described in this review represent the fundaments of ongoing translational research in the center over the past twenty years.

  6. Accountability and pediatric physician-researchers: are theoretical models compatible with Canadian lived experience?

    Directory of Open Access Journals (Sweden)

    Czoli Christine

    2011-10-01

    Full Text Available Abstract Physician-researchers are bound by professional obligations stemming from both the role of the physician and the role of the researcher. Currently, the dominant models for understanding the relationship between physician-researchers' clinical duties and research duties fit into three categories: the similarity position, the difference position and the middle ground. The law may be said to offer a fourth "model" that is independent from these three categories. These models frame the expectations placed upon physician-researchers by colleagues, regulators, patients and research participants. This paper examines the extent to which the data from semi-structured interviews with 30 physician-researchers at three major pediatric hospitals in Canada reflect these traditional models. It seeks to determine the extent to which existing models align with the described lived experience of the pediatric physician-researchers interviewed. Ultimately, we find that although some physician-researchers make references to something like the weak version of the similarity position, the pediatric-researchers interviewed in this study did not describe their dual roles in a way that tightly mirrors any of the existing theoretical frameworks. We thus conclude that either physician-researchers are in need of better training regarding the nature of the accountability relationships that flow from their dual roles or that models setting out these roles and relationships must be altered to better reflect what we can reasonably expect of physician-researchers in a real-world environment.

  7. An Application of Latent Variable Structural Equation Modeling For Experimental Research in Educational Technology

    National Research Council Canada - National Science Library

    Hyeon Woo LEE

    2011-01-01

      AN APPLICATION OF LATENT VARIABL AN APPLICATION OF LATENT VARIABLE STRUCTURAL EQUATION MODELING FOR EXPERIMENTAL RESEARCH IN EDUCATIONAL TECHNOLOGY As the technology-enriched learning environments...

  8. Research on Dynamic Model's Building of Active Magnetic Suspension Systems

    Institute of Scientific and Technical Information of China (English)

    SHI Jian; YAN Guo-zheng; LI Li-chuan; WANG Kun-dong

    2006-01-01

    An experimental method is introduced in this paper to build the dynamics of AMSS (the active magnetic suspension system), which doesn't depend on system's physical parameters. The rotor can be reliably suspended under the unit feedback control system designed with the primary dynamic model obtained. Online identification in frequency domain is processed to give the precise model. Comparisons show that the experimental method is much closer to the precise model than the theoretic method based on magnetic circuit law. So this experimental method is a good choice to build the primary dynamic model of AMSS.

  9. Research on the Adaptive Object-Model Architecture Style

    Institute of Scientific and Technical Information of China (English)

    YAO Hai-qiong; NI Gui-qiang

    2004-01-01

    The rapidly changing requirements and business rules stimulate software developers to make their applications more dynamic, configurable, and adaptable. An effective way to meet such requirements is to apply an adaptive object-model (AOM). The AOM architecture style is composed of metamodel, model engine and tools. Firstly, two small patterns for building up metamodel are analyzed in detail. Then model engine for interpreting metamodel and tools for end-uses to define and configure object models are discussed. Finally, a novel platform-applicationware-is proposed.

  10. Cupola modeling research: Phase 2 (Year one), Final report

    Energy Technology Data Exchange (ETDEWEB)

    1991-11-20

    Objective was to develop a mathematical model of the cupola furnace (cast iron production) in on-line and off-line process control and optimization. In Phase I, the general structure of the heat transfer, fluid flow, and chemical models were laid out, providing reasonable descriptions of cupola behavior with a one-dimensional representation. Work was also initiated on a two-dimensional model. Phase II was focused on perfecting the one-dimensional model. The contributions include these from MIT, Michigan University, and GM.

  11. Research on Drag Torque Prediction Model for the Wet Clutches

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Considering the surface tension effect and centrifugal effect, a mathematical model based on Reynolds equation for predicting the drag torque of disengage wet clutches is presented. The model indicates that the equivalent radius is a function of clutch speed and flow rate. The drag torque achieves its peak at a critical speed. Above this speed, drag torque drops due to the shrinking of the oil film. The model also points out that viscosity and flow rate effects on drag torque. Experimental results indicate that the model is reasonable and it performs well for predicting the drag torque peak.

  12. Applications of the Linear Logistic Test Model in Psychometric Research

    Science.gov (United States)

    Kubinger, Klaus D.

    2009-01-01

    The linear logistic test model (LLTM) breaks down the item parameter of the Rasch model as a linear combination of some hypothesized elementary parameters. Although the original purpose of applying the LLTM was primarily to generate test items with specified item difficulty, there are still many other potential applications, which may be of use…

  13. Evaluating Instructional Design Models: A Proposed Research Approach

    Science.gov (United States)

    Gropper, George L.

    2015-01-01

    Proliferation of prescriptive models in an "engineering" field is not a sign of its maturity. Quite the opposite. Materials engineering, for example, meets the criterion of parsimony. Sadly, the very large number of models in "instructional design," putatively an engineering field, raises questions about its status. Can the…

  14. Research on the Acculturation Model for Second Language Acquisition.

    Science.gov (United States)

    Schumann, John H.

    1986-01-01

    Presents a model of second language acquisition based on the social-psychology of acculturation, including factors in social, affective, personality, cognitive, biological, aptitude, personal, input, and instructional areas. Studies which test this model are reviewed and evaluated. (Author/CB)

  15. Information Search Process Model: How Freshmen Begin Research.

    Science.gov (United States)

    Swain, Deborah E.

    1996-01-01

    Investigates Kuhlthau's Search Process Model for information seeking using two Freshmen English classes. Data showed that students followed the six stages Kuhlthau proposed and suggest extensions to the model, including changing the order of the tasks, iterating and combining steps, and revising search goals based on social and interpersonal…

  16. Manifest Variable Granger Causality Models for Developmental Research: A Taxonomy

    Science.gov (United States)

    von Eye, Alexander; Wiedermann, Wolfgang

    2015-01-01

    Granger models are popular when it comes to testing hypotheses that relate series of measures causally to each other. In this article, we propose a taxonomy of Granger causality models. The taxonomy results from crossing the four variables Order of Lag, Type of (Contemporaneous) Effect, Direction of Effect, and Segment of Dependent Series…

  17. Mathematical Modelling Research in Turkey: A Content Analysis Study

    Science.gov (United States)

    Çelik, H. Coskun

    2017-01-01

    The aim of the present study was to examine the mathematical modelling studies done between 2004 and 2015 in Turkey and to reveal their tendencies. Forty-nine studies were selected using purposeful sampling based on the term, "mathematical modelling" with Higher Education Academic Search Engine. They were analyzed with content analysis.…

  18. A Reduced Wind Power Grid Model for Research and Education

    DEFF Research Database (Denmark)

    Akhmatov, Vladislav; Lund, Torsten; Hansen, Anca Daniela;

    2007-01-01

    A reduced grid model of a transmission system with a number of central power plants, consumption centers, local wind turbines and a large offshore wind farm is developed and implemented in the simulation tool PowerFactory (DIgSILENT). The reduced grid model is given by Energinet.dk, Transmission ...

  19. Research on application of intelligent computation based LUCC model in urbanization process

    Science.gov (United States)

    Chen, Zemin

    2007-06-01

    Global change study is an interdisciplinary and comprehensive research activity with international cooperation, arising in 1980s, with the largest scopes. The interaction between land use and cover change, as a research field with the crossing of natural science and social science, has become one of core subjects of global change study as well as the front edge and hot point of it. It is necessary to develop research on land use and cover change in urbanization process and build an analog model of urbanization to carry out description, simulation and analysis on dynamic behaviors in urban development change as well as to understand basic characteristics and rules of urbanization process. This has positive practical and theoretical significance for formulating urban and regional sustainable development strategy. The effect of urbanization on land use and cover change is mainly embodied in the change of quantity structure and space structure of urban space, and LUCC model in urbanization process has been an important research subject of urban geography and urban planning. In this paper, based upon previous research achievements, the writer systematically analyzes the research on land use/cover change in urbanization process with the theories of complexity science research and intelligent computation; builds a model for simulating and forecasting dynamic evolution of urban land use and cover change, on the basis of cellular automation model of complexity science research method and multi-agent theory; expands Markov model, traditional CA model and Agent model, introduces complexity science research theory and intelligent computation theory into LUCC research model to build intelligent computation-based LUCC model for analog research on land use and cover change in urbanization research, and performs case research. The concrete contents are as follows: 1. Complexity of LUCC research in urbanization process. Analyze urbanization process in combination with the contents

  20. Gulf of Mexico dissolved oxygen model (GoMDOM) research and quality assurance project plan

    Science.gov (United States)

    An integrated high resolution mathematical modeling framework is being developed that will link hydrodynamic, atmospheric, and water quality models for the northern Gulf of Mexico. This Research and Quality Assurance Project Plan primarily focuses on the deterministic Gulf of Me...

  1. History of Physics Education Research as a Model for Geoscience Education Research Community Progress

    Science.gov (United States)

    Slater, T. F.

    2011-12-01

    Discipline-based Education Research (DBER) is a research field richly combining a deep understanding of how to teach a particular discipline with an evolving understanding how people learn that discipline. At its center, DBER has an overarching goal of improving the teaching and learning of a discipline by focusing on understanding the underlying mental mechanisms learners use as they develop expertise. Geoscience Education Research, or GER, is a young but rapidly advancing field which is poised to make important contributions to the teaching and learning of earth and space science. Nascent geoscience education researchers could accelerate their community's progress by learning some of the lessons from the more mature field of Physics Education Research, PER. For the past three decades, the PER community has been on the cutting edge of DBER. PER started purely as an effort among traditionally trained physicists to overcome students' tenaciously held misconceptions about force, motion, and electricity. Over the years, PER has wrestled with the extent to which they included the faculty from the College of Education, the value placed on interpretive and qualitative research methods, the most appropriate involvement of professional societies, the nature of its PhD programs in the College of Science, and how to best disseminate the results of PER to the wider physics teaching community. Decades later, as a more fully mature field, PER still struggles with some of these aspects, but has learned important lessons in how its community progresses and evolves to be successful, valuable, and pertinent.

  2. Research on Architecture of Enterprise Modeling in Workflow System

    Institute of Scientific and Technical Information of China (English)

    李伟平; 齐慧彬; 薛劲松; 朱云龙

    2002-01-01

    The market that an enterprise is faced is changing and can 't be forecastedaccurately in this information time. In order to find the chances in the marketpractitioners have focused on business processes through their re-engineeringprogramme to improve enterprise efficiency. It is necessary to manage an enterpriseusing process-based method for the requirement of enhancing work efficiency and theability of competition in the market. And information system developers haveemphasized the use of standard models to accelerate the speed of configuration andimplementation of integrated systems for enterprises. So we have to model anenterprise with process-based modeling method. An architecture of enterprise modelingis presented in this paper. This architecture is composed of four views and supportingthe whole lifecycle of enterprise model. Because workflow management system is basedon process definition, this architecture can be directly used in the workflowmanagement system. The implement method of this model was thoroughly describedmeanwhile the workflow management software supporting the building and running themodel was also given.

  3. Usefulness of animal models for tuberculosis research-A review

    Institute of Scientific and Technical Information of China (English)

    Isamu Sugawara

    2012-01-01

    When Mycobacterium tuberculosis infects humans, about 20% of those infected actually develop tuberculosis. In Japan, the incidence of tuberculosis in 2008 was 19.4/100 000 persons (24 760 cases) and the rate has been decreasing gradually, but is still higher than that in the USA, Holland, and Belgium, for example. Histologically, experimental tuberculosis displays exudative inflammation, proliferative inflammation and productive inflammation depending on the time course. In productive inflammation, granulomatous lesions with necrotic centers are formed. The typical granulomas consist of epithelioid macrophages, Langhans' multinucleated giant cells, lymphocytes and fibroblasts, and the process of their formation involves many cytokines, chemokines and transcription factors. These findings have been derived primarily from animal experiments utilizing an airborne infection apparatus. This review focuses on the basic research aspect of tuberculosis-what has been found through animal experiments by our research group-and furthermore, indicates what we should do in tuberculosis research in the near future.

  4. A Model For Creating Innovators Through Freshman Research

    Science.gov (United States)

    Winget, Donald E.; Montgomery, M. H.

    2013-01-01

    Students come to the College of Natural Sciences because they want to do research, not because they want to sit in the classroom. The University of Texas Freshman Research Initiative (FRI) is designed to leverage this desire. It motivates, stimulates and educates the next generation of scientists by getting them directly involved in cutting edge research in their first year of college. They initially contribute to a group project designed for them to build the skills needed for research. Within the first year they develop a more independent project. After four years with the Astronomy Stream of the FRI, our first group has graduated. Three of the six have produced honors theses and a fourth is working on one this fall. Three were Dean's Honored Graduates. Of these two were female and one male. Two are in graduate programs and one is admitted to medical school. One won the George Mitchell Award as the outstanding undergraduate student at the University of Texas. Subsequent classes hold similar promise. The success at recruiting and retaining these students, with minorities and women well represented, is traceable to at least three key factors. First, the research introduces them to the transformative and addictive joy of knowing something about the universe that no one, past or present, has ever known before. Second it gives them a context for the knowledge they gain in the classroom. Third it allows them to develop a network of peers and mentors. The mentors are layered, with upper division undergraduates serving as the first line, then graduate students, post docs and faculty. They always have access to help in their research and in their class work. The end result is that they perform significantly better in the classroom than their peers that are not involved in an FRI stream. We will discuss future plans for the FRI: how we plan to expand to larger groups and how the concept can be exported to other universities.

  5. CONSERVATION PROCESS MODEL (CPM: A TWOFOLD SCIENTIFIC RESEARCH SCOPE IN THE INFORMATION MODELLING FOR CULTURAL HERITAGE

    Directory of Open Access Journals (Sweden)

    D. Fiorani

    2017-05-01

    Full Text Available The aim of the present research is to develop an instrument able to adequately support the conservation process by means of a twofold approach, based on both BIM environment and ontology formalisation. Although BIM has been successfully experimented within AEC (Architecture Engineering Construction field, it has showed many drawbacks for architectural heritage. To cope with unicity and more generally complexity of ancient buildings, applications so far developed have shown to poorly adapt BIM to conservation design with unsatisfactory results (Dore, Murphy 2013; Carrara 2014. In order to combine achievements reached within AEC through BIM environment (design control and management with an appropriate, semantically enriched and flexible The presented model has at its core a knowledge base developed through information ontologies and oriented around the formalization and computability of all the knowledge necessary for the full comprehension of the object of architectural heritage an its conservation. Such a knowledge representation is worked out upon conceptual categories defined above all within architectural criticism and conservation scope. The present paper aims at further extending the scope of conceptual modelling within cultural heritage conservation already formalized by the model. A special focus is directed on decay analysis and surfaces conservation project.

  6. Conservation Process Model (cpm): a Twofold Scientific Research Scope in the Information Modelling for Cultural Heritage

    Science.gov (United States)

    Fiorani, D.; Acierno, M.

    2017-05-01

    The aim of the present research is to develop an instrument able to adequately support the conservation process by means of a twofold approach, based on both BIM environment and ontology formalisation. Although BIM has been successfully experimented within AEC (Architecture Engineering Construction) field, it has showed many drawbacks for architectural heritage. To cope with unicity and more generally complexity of ancient buildings, applications so far developed have shown to poorly adapt BIM to conservation design with unsatisfactory results (Dore, Murphy 2013; Carrara 2014). In order to combine achievements reached within AEC through BIM environment (design control and management) with an appropriate, semantically enriched and flexible The presented model has at its core a knowledge base developed through information ontologies and oriented around the formalization and computability of all the knowledge necessary for the full comprehension of the object of architectural heritage an its conservation. Such a knowledge representation is worked out upon conceptual categories defined above all within architectural criticism and conservation scope. The present paper aims at further extending the scope of conceptual modelling within cultural heritage conservation already formalized by the model. A special focus is directed on decay analysis and surfaces conservation project.

  7. Regulatory ozone modeling: Status, directions, and research needs

    Energy Technology Data Exchange (ETDEWEB)

    Georgopoulos, P.G. [Environmental and Occupational Health Sciences Institute, Piscataway, NJ (United States)

    1995-03-01

    The Clean Air Act Amendments (CAAA) of 1990 have established selected comprehensive, three-dimensional, Photochemical Air Quality Simulation Models (PAQSMs) as the required regulatory tools for analyzing the urban and regional problem of high ambient ozone levels across the United States. These models are currently applied to study and establish strategies for meeting the National Ambient Air Quality Standard (NAAQS) for ozone in nonattainment areas; State Implementation Plans (SIPs) resulting from these efforts must be submitted to the U.S. Environmental Protection Agency (U.S. EPA) in November 1994. The following presentation provides an overview and discussion of the regulatory ozone modeling process and its implications. First, the PAQSM-based ozone attainment demonstration process is summarized in the framework of the 1994 SIPs. Then, following a brief overview of the representation of physical and chemical processes in PAOSMs, the essential attributes of standard modeling systems currently in regulatory use are presented in a nonmathematical, self-contained format, intended to provide a basic understanding of both model capabilities and limitations. The types of air quality, emission, and meteorological data needed for applying and evaluating PAOSMs are discussed, as well as the sources, availability, and limitations of existing databases. The issue of evaluating a model`s performance in order to accept it as a tool for policy making is discussed, and various methodologies for implementing this objective are summarized. 43 refs., 9 figs.

  8. Research on Dependable Ionizing Radiation Protection based on Model i*

    Directory of Open Access Journals (Sweden)

    Tan Hai

    2013-07-01

    Full Text Available The software’s unreliability mostly attributes to an erroneous analysis on the requirements done at the beginning. In this paper, we apply the tool of i* frame requirement modeling and build early requirement model against ionizing radiation. After finding out possible risks and corresponding solutions during the process of modeling analysis, we propose reasoning models against ionizing radiation. The radiation protection system  with  the  above models  can  figure out  the  purpose  of agents  related  to radiant source and provide normal service even when the environment software system is being interfered. It can serve the ecological and economical society with stability and development.  The model is divided into several sections. Section 1 gives the outline of the dependant software. Section 2 illustrates the  i* frame  technology. Section 3, 4 and 5 cover the topic of dependant security requirement analysis, SD&SR model on ionizing radiation respectively. Section 6 gives the conclusion.

  9. Structural equation modeling in the context of clinical research

    Science.gov (United States)

    2017-01-01

    Structural equation modeling (SEM) has been widely used in economics, sociology and behavioral science. However, its use in clinical medicine is quite limited, probably due to technical difficulties. Because SEM is particularly suitable for analysis of complex relationships among observed variables, it must have potential applications to clinical medicine. The article introduces basic ideas of SEM in the context of clinical medicine. A simulated dataset is employed to show how to do model specification, model fit, visualization and assessment of goodness-of-fit. The first example fits a SEM with continuous outcome variable using sem() function, and the second explores the binary outcome variable using lavaan() function. PMID:28361067

  10. Probe Error Modeling Research Based on Bayesian Network

    Institute of Scientific and Technical Information of China (English)

    Wu Huaiqiang; Xing Zilong; Zhang Jian; Yan Yan

    2015-01-01

    Probe calibration is carried out under specific conditions; most of the error caused by the change of speed parameter has not been corrected. In order to reduce the measuring error influence on measurement accuracy, this article analyzes the relationship between speed parameter and probe error, and use Bayesian network to establish the model of probe error. Model takes account of prior knowledge and sample data, with the updating of data, which can reflect the change of the errors of the probe and constantly revised modeling results.

  11. Community media research : a quest for theoretically-grounded models

    NARCIS (Netherlands)

    Jankowski, N.W.

    2003-01-01

    This article provides a panoramic sketch of the characteristics of community media and focuses on three forms: community television, community radio and community networks. The author contends, after a review of research conducted around these media, that much of this work has contributed little to

  12. Structural Models and Dynamic Organizational Research: A Possibility Theorem.

    Science.gov (United States)

    Welty, Gordon; Beradino, Alfred

    This paper deals with the problems of rigorous research within the dynamic organizational context. Definitions and axioms establish the natures of a social problem, a social intervention program, continuous program monitoring, a method of describing alternative treatments, treatment effect testing, and programmatic change. These definitions and…

  13. Promoting Writing for Research: The "Writing Retreat" Model

    Science.gov (United States)

    Singh, R. J.

    2012-01-01

    Research papers take a long time to write and in an academic environment where the "publish or perish" clause applies, writing retreats are a way of creating time and space to write academic articles in a concentrated period of time. This article examines ways in which academics can write more articles for publication. In particular it…

  14. What kind of causal modelling approach does personality research need?

    NARCIS (Netherlands)

    Borsboom, D.; van der Sluis, S.; Noordhof, A.; Wichers, M.; Geschwind, N.; Aggen, S.H.; Kendler, K.S.; Cramer, A.O.J.

    2012-01-01

    Lee (2012) proposes that personality research should utilise recent theories of causality. Although we agree that such theories are important, we also note that their empirical application has not been very successful to date. The reason may be that psychological systems are frequently characterised

  15. Sheep: The First Large Animal Model in Nuclear Transfer Research

    OpenAIRE

    Loi, Pasqualino; Czernik, Marta; Zacchini, Federica; Iuso, Domenico; Scapolo, Pier Augusto; Ptak, Grazyna

    2013-01-01

    The scope of this article is not to provide an exhaustive review of nuclear transfer research, because many authoritative reviews exist on the biological issues related to somatic and embryonic cell nuclear transfer. We shall instead provide an overview on the work done specifically on sheep and the value of this work on the greater nuclear transfer landscape.

  16. RESEARCH ON VIRTUAL-PART-BASED CONNECTING ELEMENT MODELING

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    Based on the inner character analysis of interpart, detail modification and assembly relation of mechanical connecting element, the idea, which extends the feature modeling of part to the interpart feature modeling for assembly purpose, is presented, and virtual-part-based connecting element modeling is proposed. During the assembly modeling, base parts are modified by the Boolean subtraction between the virtual part and the part to be connected. Dynamic matching algorithm, which is based on list database, is designed for dynamic extension and off-line editing of connecting part and virtual part, and design rules of connecting element is encapsulated by the virtual part. A prototyped software module for rapid design of connecting elements is implemented under self-developed CAD/CAM platform-SuperMan.

  17. Experimental models in vaccine research: malaria and leishmaniasis.

    Science.gov (United States)

    Teixeira, C; Gomes, R

    2013-02-01

    Animal models have a long history of being useful tools, not only to test and select vaccines, but also to help understand the elaborate details of the immune response that follows infection. Different models have been extensively used to investigate putative immunological correlates of protection against parasitic diseases that are important to reach a successful vaccine. The greatest challenge has been the improvement and adaptation of these models to reflect the reality of human disease and the screening of vaccine candidates capable of overcoming the challenge of natural transmission. This review will discuss the advantages and challenges of using experimental animal models for vaccine development and how the knowledge achieved can be extrapolated to human disease by looking into two important parasitic diseases: malaria and leishmaniasis.

  18. Research on viral dynamic models of hepatitis B virus infection

    Institute of Scientific and Technical Information of China (English)

    Lequan Min; Xisong Dong

    2004-01-01

    A mathematical model with cytotoxic cells of hepatitis B virus (HBV) infection is set up based on a basic model of virus dynamics without cytotoxic cells and experimental observation of anti-viral drug therapy for HBV infection patients. A quantitative analysis of dynamic behaviors shows that the model has three kinds of equilibrium points, which represent the patient's complete recovery without immune ability, complete recovery with immune ability, and HBV persistent infection at the end of the treatment with drug lamivudine, respectively. Our model may provide possible quantitative interpretations for the treatments of chronic HBV infections with the drug lamivudine, in particularly explain why the plasma virus of Nowak et al.'s patients turnover the original level after stopping the lamivudine treatment.

  19. A Model of Research Paper Writing Instructional Materials for Academic Writing Course: "Needs & Documents Analysis and Model Design"

    Science.gov (United States)

    Ghufron, M. Ali; Saleh, Mursid; Warsono; Sofwan, Ahmad

    2016-01-01

    This study aimed at designing a model of instructional materials for Academic Writing Course focusing on research paper writing. The model was designed based on the Curriculum at the English Education Study Program, Faculty of Language and Art Education of IKIP PGRI Bojonegoro, East Java, Indonesia. This model was developed in order to improve…

  20. Research on Knowledge-based Connecting Elements Modeling

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Steps of manipulation is required to complete the m od eling of the connection elements such as bolt, pin and the like in commerce CAD system. It leads to low efficiency, difficulty to assure the relative position, impossibility to express rules and knowledge. Based on the inner character analy sis of interpart, detail modification and assembly relation of mechanical connec ting element, the idea, which extends the feature modeling of part to the interp art feature modeling for assembly purpose, is presen...

  1. Research on Teaching Model in Business English Writing

    Institute of Scientific and Technical Information of China (English)

    WEN Chuan-shu

    2014-01-01

    According to the characteristics of Business English Writing Course,this essay analyses the teaching status, then in the frame of communication theory, it puts forward a new teaching model-PIADA. It is proved that this new teaching model can explore the teacher’s subjective initiative, mobilize the enthusiasm of the students fully, make the teaching process more systemat-ic and scientific, and eventually greatly improve students' English writing ability.

  2. Rabbit as an animal model for experimental research

    OpenAIRE

    Manjeet Mapara; Betsy Sara Thomas; Bhat, K. M.

    2012-01-01

    Animal experimentation is carried out in consultation with the veterinary wing but it is essential that be familiar with experimental protocols of animal model to be able to design an approriate study. This is more so in place where the veterinary facilities are not easily available.Span Rabbits are commonly used as subjects for screening implant material. They have gained favour for their numerous advantages even though they should be ideally used prior to testing in a larger animal model. T...

  3. Ozone flux modelling for risk assessment: status and research needs

    Directory of Open Access Journals (Sweden)

    Tuovinen J-P

    2009-01-01

    Full Text Available In this paper, some shortcomings involved in the modelling of ozone fluxes in the context of local-scale risk assessment are discussed, especially as related to the data collected within the International Co-operative Programme on Assessment and Monitoring of Air Pollution Effects on Forests (ICP Forests. An enhanced monitoring strategy, that would provide a sounder basis for the development, validation and application of risk assessment modelling tools, is also suggested.

  4. Research of ERP model system of spatial data warehouse

    Institute of Scientific and Technical Information of China (English)

    CHEN Xue-long; WANG Yan-zhang

    2004-01-01

    The broad sharing of spatial information is demanded in the infrastructure construction of spatial data in our country. And the spatial data warehouse realizes the effective management and sharing of spatial information serving as an efficient tool. This article proposes ERP model system that of general-decision-oriented for constructing spatial data warehouse from the aspect of decision application. In the end of article, the construction process of spatial data warehouse based on ERP model system is discussed.

  5. Rabbit as an animal model for experimental research

    OpenAIRE

    Manjeet Mapara; Betsy Sara Thomas; Bhat, K. M.

    2012-01-01

    Animal experimentation is carried out in consultation with the veterinary wing but it is essential that be familiar with experimental protocols of animal model to be able to design an approriate study. This is more so in place where the veterinary facilities are not easily available.Span Rabbits are commonly used as subjects for screening implant material. They have gained favour for their numerous advantages even though they should be ideally used prior to testing in a larger animal model. T...

  6. PBPK modeling and simulation in drug research and development

    OpenAIRE

    Xiaomei Zhuang; Chuang Lu

    2016-01-01

    Physiologically based pharmacokinetic (PBPK) modeling and simulation can be used to predict the pharmacokinetic behavior of drugs in humans using preclinical data. It can also explore the effects of various physiologic parameters such as age, ethnicity, or disease status on human pharmacokinetics, as well as guide dose and dose regiment selection and aid drug–drug interaction risk assessment. PBPK modeling has developed rapidly in the last decade within both the field of academia and the phar...

  7. An engineering approach to business model experimentation – an online investment research startup case study

    NARCIS (Netherlands)

    Kijl, Björn; Boersma, Durk

    2010-01-01

    Every organization needs a viable business model. Strikingly, most of current literature is focused on business model design, whereas there is almost no attention for business model validation and implementation and related business model experimentation. The goal of the research as described in

  8. An engineering approach to business model experimentation – an online investment research startup case study

    NARCIS (Netherlands)

    Kijl, Björn; Boersma, Durk

    2010-01-01

    Every organization needs a viable business model. Strikingly, most of current literature is focused on business model design, whereas there is almost no attention for business model validation and implementation and related business model experimentation. The goal of the research as described in thi

  9. The sheep as a large osteoporotic model for orthopaedic research in humans

    DEFF Research Database (Denmark)

    Cheng, L.; Ding, Ming; Li, Z.;

    2008-01-01

    Although small animals as rodents are very popular animals for osteoporosis models , large animals models are necessary for research of human osteoporotic diseases. Sheep osteoporosis models are becoming more important because of its unique advantages for osteoporosis reseach. Sheep are docile...... intake restriction and glucocorticoid application are the most effective methods for sheep osteoporosis model. Sheep osteoporosis model is an ideal animal model for studying various medicines reacting to osteoporosis and other treatment methods such as prosthetic replacement reacting to osteoporotic...

  10. Multidisciplinary collaboration as a sustainable research model for device development.

    Science.gov (United States)

    Chandra, Ankur

    2013-02-01

    The concurrent problems of research sustainability and decreased clinician involvement with medical device development can be jointly addressed through a novel, multidisciplinary solution. The University of Rochester Cardiovascular Device Design Program is a sustainable program in medical device design supported through a collaboration between the Schools of Medicine and Engineering. This article provides a detailed description of the motivation for starting the program, the current structure of the program, the methods of financial sustainability, and the direct impact it intends to have on the national vascular surgery community. The further expansion of this program and encouragement for development of similar programs throughout the country aims to address many of our current challenges in both research funding and device development education.

  11. Model Based Cyber Security Analysis for Research Reactor Protection System

    Energy Technology Data Exchange (ETDEWEB)

    Sho, Jinsoo; Rahman, Khalil Ur; Heo, Gyunyoung [Kyung Hee Univ., Yongin (Korea, Republic of); Son, Hanseong [Joongbu Univ., Geumsan (Korea, Republic of)

    2013-07-01

    The study on the qualitative risk due to cyber-attacks into research reactors was performed using bayesian Network (BN). This was motivated to solve the issues of cyber security raised due to digitalization of instrumentation and control (I and C) system. As a demonstrative example, we chose the reactor protection system (RPS) of research reactors. Two scenarios of cyber-attacks on RPS were analyzed to develop mitigation measures against vulnerabilities. The one is the 'insertion of reactor trip' and the other is the 'scram halt'. The six mitigation measures are developed for five vulnerability for these scenarios by getting the risk information from BN.

  12. Research in Supercritical Fuel Properties and Combustion Modeling

    Science.gov (United States)

    2015-09-18

    any significant impact on the normal hydrocarbon oxidation kinetics . These are ethanol, dimethyl ether( DME ), and methyl formate (C2H5OH, CH3OCH3...research are to develop stimulated scattering as a diagnostic for supercritical fluids, and to evaluate reaction kinetics inputs involving 2-4...measurements for refractive index measurements, and tested our supercritical cell. On the reaction kinetics task, review and evaluation of reactions, rate

  13. Education as Sustainability: An Action Research Study of the Burns Model of Sustainability Pedagogy

    Science.gov (United States)

    Burns, Heather

    2009-01-01

    Postsecondary teaching and learning must be reoriented to equip learners with the knowledge, skills, and values they will need for creating a more sustainable world. This action research study examined the effects of implementing the "Burns model of sustainability pedagogy" in university courses taught by the researcher. This model is comprised of…

  14. Finite Mixture Multilevel Multidimensional Ordinal IRT Models for Large Scale Cross-Cultural Research

    NARCIS (Netherlands)

    M.G. de Jong (Martijn); J-B.E.M. Steenkamp (Jan-Benedict)

    2009-01-01

    textabstractWe present a class of finite mixture multilevel multidimensional ordinal IRT models for large scale cross-cultural research. Our model is proposed for confirmatory research settings. Our prior for item parameters is a mixture distribution to accommodate situations where different groups

  15. Toward a General Research Process for Using Dubin's Theory Building Model

    Science.gov (United States)

    Holton, Elwood F.; Lowe, Janis S.

    2007-01-01

    Dubin developed a widely used methodology for theory building, which describes the components of the theory building process. Unfortunately, he does not define a research process for implementing his theory building model. This article proposes a seven-step general research process for implementing Dubin's theory building model. An example of a…

  16. Toward a General Research Process for Using Dubin's Theory Building Model

    Science.gov (United States)

    Holton, Elwood F.; Lowe, Janis S.

    2007-01-01

    Dubin developed a widely used methodology for theory building, which describes the components of the theory building process. Unfortunately, he does not define a research process for implementing his theory building model. This article proposes a seven-step general research process for implementing Dubin's theory building model. An example of a…

  17. Operationalizing the Concept of Value--An Action Research-Based Model

    Science.gov (United States)

    Naslund, Dag; Olsson, Annika; Karlsson, Sture

    2006-01-01

    Purpose: While the importance of measuring customer satisfaction levels is well established, less research exists on how organizations operationalize such knowledge. The purpose of this paper is to describe an action research (AR) case study resulting in a workshop model to operationalize the concept of value. The model facilitates organizational…

  18. PBPK modeling and simulation in drug research and development

    Directory of Open Access Journals (Sweden)

    Xiaomei Zhuang

    2016-09-01

    Full Text Available Physiologically based pharmacokinetic (PBPK modeling and simulation can be used to predict the pharmacokinetic behavior of drugs in humans using preclinical data. It can also explore the effects of various physiologic parameters such as age, ethnicity, or disease status on human pharmacokinetics, as well as guide dose and dose regiment selection and aid drug–drug interaction risk assessment. PBPK modeling has developed rapidly in the last decade within both the field of academia and the pharmaceutical industry, and has become an integral tool in drug discovery and development. In this mini-review, the concept and methodology of PBPK modeling are briefly introduced. Several case studies were discussed on how PBPK modeling and simulation can be utilized through various stages of drug discovery and development. These case studies are from our own work and the literature for better understanding of the absorption, distribution, metabolism and excretion (ADME of a drug candidate, and the applications to increase efficiency, reduce the need for animal studies, and perhaps to replace clinical trials. The regulatory acceptance and industrial practices around PBPK modeling and simulation is also discussed.

  19. [Exploration and research of community management model for asthmatic children].

    Science.gov (United States)

    Li, Jingpeng; Wei, Hong; Li, Xuejun; Wang, Mengmeng; Wang, Genxiang; Zhao, Shunying

    2014-05-01

    To study the efficacy of community management model of bronchial asthma in children. Through community outreach and clinic, 120 cases of children with asthma were enrolled from the 11 000 children aged 0 to 14 in Zhanlanlu area, and a community management model of asthma was established according to the Global Initiative for Asthma requirements combined with the actual situation of the community, both physicians and patients participated in case identification, file creation, and long-term standardized management. Through repeated medical education, the telephone hotline and interactive network of asthma among physicians, children and parents, a physician-patient relationship was established. The data of standardized medication, scheduled re-visit to the hospital, frequency of asthma attacks, antibiotic use, medical expenses, the loss of parents work hours etc. before and after the implementation of community management model were analyzed and compared. After implementation of community management model, the use of systemic corticosteroids (19.4%), oral medication (31.6%) was significantly lower than those before implementation (68.3% and 90.0%) (χ(2) = 51.9, 41.1, P management level (10.0%), χ(2) = 106.0, P management, eventually the dropout rate was 9.2%. Enrollment of children with bronchial asthma into community management model made the children adhere to the management regularly and a standardized management was achieved.

  20. The Python Project: A Unique Model for Extending Research Opportunities to Undergraduate Students

    Science.gov (United States)

    Harvey, Pamela A.; Wall, Christopher; Luckey, Stephen W.; Langer, Stephen; Leinwand, Leslie A.

    2014-01-01

    Undergraduate science education curricula are traditionally composed of didactic instruction with a small number of laboratory courses that provide introductory training in research techniques. Research on learning methodologies suggests this model is relatively ineffective, whereas participation in independent research projects promotes enhanced…

  1. Implementing a Service Learning Model for Teaching Research Methods and Program Evaluation

    Science.gov (United States)

    Shannon, Patrick; Kim, Wooksoo; Robinson, Adjoa

    2012-01-01

    In an effort to teach students the basic knowledge of research methods and the realities of conducting research in the context of agencies in the community, faculty developed and implemented a service learning model for teaching research and program evaluation to foundation-year MSW students. A year-long foundation course was designed in which one…

  2. Easing the adoption of agent-based modelling (ABM) in tourism research

    NARCIS (Netherlands)

    Johnson, Peter; Nicholls, Sarah; Student, Jillian; Amelung, Bas; Baggio, Rodolfo; Balbi, Stefano; Boavida-Portugal, Ines; Jong, de Eline; Hofstede, G.J.; Lamers, M.A.J.; Pons, Marc; Steiger, Robert

    2016-01-01

    Agent-based modelling (ABM) is an emerging approach in tourism research. Despite the natural fit between theories of tourism as a complex, interconnected system, and the generative approach supported in ABM, there has been only limited integration within mainstream tourism research. This research le

  3. Easing the adoption of agent-based modelling (ABM) in tourism research

    NARCIS (Netherlands)

    Johnson, Peter; Nicholls, Sarah; Student, Jillian; Amelung, Bas; Baggio, Rodolfo; Balbi, Stefano; Boavida-Portugal, Ines; Jong, de Eline; Hofstede, G.J.; Lamers, M.A.J.; Pons, Marc; Steiger, Robert

    2017-01-01

    Agent-based modelling (ABM) is an emerging approach in tourism research. Despite the natural fit between theories of tourism as a complex, interconnected system, and the generative approach supported in ABM, there has been only limited integration within mainstream tourism research. This research

  4. Implementing a Service Learning Model for Teaching Research Methods and Program Evaluation

    Science.gov (United States)

    Shannon, Patrick; Kim, Wooksoo; Robinson, Adjoa

    2012-01-01

    In an effort to teach students the basic knowledge of research methods and the realities of conducting research in the context of agencies in the community, faculty developed and implemented a service learning model for teaching research and program evaluation to foundation-year MSW students. A year-long foundation course was designed in which one…

  5. The Python Project: A Unique Model for Extending Research Opportunities to Undergraduate Students

    Science.gov (United States)

    Harvey, Pamela A.; Wall, Christopher; Luckey, Stephen W.; Langer, Stephen; Leinwand, Leslie A.

    2014-01-01

    Undergraduate science education curricula are traditionally composed of didactic instruction with a small number of laboratory courses that provide introductory training in research techniques. Research on learning methodologies suggests this model is relatively ineffective, whereas participation in independent research projects promotes enhanced…

  6. Zebrafish embryos and larvae as a complementary model for behavioural research

    NARCIS (Netherlands)

    Ahmad, Farooq

    2014-01-01

    The main focus of the research that makes up this thesis was to translate rodent behavioural assays to larval zebrafish for better time and resource management in biomedical research, pharmaceutical research and development. •The larval zebrafish is a useful model in toxicology and drug discovery. H

  7. Teaching research in clinical pastoral education: a survey of model practices.

    Science.gov (United States)

    Tartaglia, Alexander; Fitchett, George; Dodd-McCue, Diane; Murphy, Patricia; Derrickson, Paul E

    2013-03-01

    The Association of Professional Chaplains (APC) developed Standards of Practice for Acute and Long-term settings. Standard 12 promotes research-literate chaplains as important for the profession. Since many chaplains receive training in clinical pastoral education (CPE) residency programs, the aim of this study was to identify model practices for the teaching of research in such programs. Using a purposeful sample, this study identified 11 programs that offered "consistent and substantive" education in research. Common features included the existence of a research champion, a culture supportive of research, and the availability of institutional resources. The study identified models and methodologies that CPE programs can adopt.

  8. Application of Z-Number Based Modeling in Psychological Research

    Directory of Open Access Journals (Sweden)

    Rafik Aliev

    2015-01-01

    Full Text Available Pilates exercises have been shown beneficial impact on physical, physiological, and mental characteristics of human beings. In this paper, Z-number based fuzzy approach is applied for modeling the effect of Pilates exercises on motivation, attention, anxiety, and educational achievement. The measuring of psychological parameters is performed using internationally recognized instruments: Academic Motivation Scale (AMS, Test of Attention (D2 Test, and Spielberger’s Anxiety Test completed by students. The GPA of students was used as the measure of educational achievement. Application of Z-information modeling allows us to increase precision and reliability of data processing results in the presence of uncertainty of input data created from completed questionnaires. The basic steps of Z-number based modeling with numerical solutions are presented.

  9. IOT technology application model research of transportation industry in China

    Institute of Scientific and Technical Information of China (English)

    Lai Mingyong; Zhou Tang; Liu Zhengchi

    2013-01-01

    The paper studied the connection between intemet of things (IOT) technology and transportation industry.Meanwhile,the definition of IOT in transportation was given.Concerning that many problems occurred during the process of traditional intelligent transportation system,the paper proposed a promising model of IOT in transportation.The advantage of the information utilization model from information to function was confirmed through comparative study.Finally,the model presented that a real interconnection of transportation would be achieved based on the unified information collection.It can greatly save cost on technology transfer,exploit potential value of information,and promote the emergence of a sustainable information service market and the industrial upgrade.

  10. Research on the Construction of Food Industrial Correlation Network Model

    Directory of Open Access Journals (Sweden)

    Yu Zhenlei

    2015-05-01

    Full Text Available As the objective existence of economy, the relational and spatial structure of Industrial correlation not only determines the quality and level of economic growth, but is regarded as the important source of gaining competitive advantages. Based on the input-output model and network model of food industry, this study focuses on the method and application of the construction of food industrial correlation network model. Analyzing the connotation of food industrial correlation, the article finds the way to describe it with graphs. What’s more, these graphs and network theory are used to design the index coefficient of industrial correlation to show the food industrial correlation and its structure feature.

  11. Research model of the environmental management in hotel firms

    Directory of Open Access Journals (Sweden)

    Yaiza Armas Cruz

    2010-10-01

    Full Text Available The current work aims to develop a instrument to measure the impact of firms’ environmental protection activities on their economic performance. This tool is specifically designed for the tourism sector, which is rarely analysed from this perspective despite its considerable relevance due to its strong interaction with the environment. The work empirically tests the model on a sample of hotels in Canary Islands (Spain. It uses structural equation modelling to analyse the information. The findings show that the proposed model fits the underlying reality well, and its constituent components satisfy validity and reliability criteria. Thus, they make an important contribution to knowledge about the determinants and implications of sustainability in tourism-sector firms.

  12. Rabbit as an animal model for experimental research.

    Science.gov (United States)

    Mapara, Manjeet; Thomas, Betsy Sara; Bhat, K M

    2012-01-01

    Animal experimentation is carried out in consultation with the veterinary wing but it is essential that be familiar with experimental protocols of animal model to be able to design an approriate study. This is more so in place where the veterinary facilities are not easily available.Span Rabbits are commonly used as subjects for screening implant material. They have gained favour for their numerous advantages even though they should be ideally used prior to testing in a larger animal model. Though experimentation on rabbits seems to be easy there are many pitfalls. Our endeavor in this article is to integrate all the data about maintaining rabbits as a model and to critically analyze it on the basis of our experimentation.

  13. Research of Anti-Plagiarism Monitoring System Model

    Institute of Scientific and Technical Information of China (English)

    SHEN Yang; YUAN Zhongshang; LIU Lu; DONG Hui

    2007-01-01

    We proposed a flexible anti-plagiarism system model based on user-defined plagiarism standards. We also proposed PlagLazy and format-legacy phenomena that plagiarist will remain format-legacy such as soft-enter symbol in his DOC document after plagiarizing material from web and corresponding optimized algorithm which improves the speed of comparison. Our model is suitable for the anti-plagiarism and monitoring of large document collections, and it can also be used in digital library, E-learning and other fields.

  14. Mathematical model research on landslide monitoring through GPS

    Institute of Scientific and Technical Information of China (English)

    LIU Wen-wei; SONG Ying-chun; ZHU Jian-jun; TANG Jing-tian

    2006-01-01

    Assuming that road slope and landslide object are rigid, the landslide's moving displacement was drawn based on their geometry shapes and the physi-mechanical features of materials, and the dynamic model of landslide was also set up, then DDOD(double difference observation data) was combined with the deformed monitoring point and the carrier phase observation data on base point, which can be used to monitor the landslide's deformation rule from horizontal, vertical and directional view simultaneously. Observing equation was set up, which sufficiently reflects the activities of landslide in entire directions. Filter model includes some information such as mechanical state and GPS observing data by Kalman filter.

  15. RESEARCH ON SEEPAGE MONITORING MODEL OF EARTH-ROCK DAM

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    With the characteristics of seepage flow in earth-rock dams, a seepage monitoring model was established based on the finite element method for 3-D seepage flow together with observed data and was used to analyze and monitor the seepage of dams. In order to find out and monitor the seepage status of the whole dam, the separation of seepage amount for dam body, dam foundation and side banks was made theoretically by using the model. Practical example shows that the accuracy of computed results is satisfactory and the separation results are more objective.

  16. Research on Maintainability Evaluation Model Based on Fuzzy Theory

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Maintainability influencing attributes are analyzed, their weight and value calculating methods are given, and the maintainability fuzzy evaluation method is proposed based on the relative closeness. According to the maintenance task simulation operated in virtual environment, the maintainability virtual evaluation model is built by analyzing the maintenance task for each replaceable unit of product.At last, a case study is given based upon the main landing gear system of a certain type civil aircraft, and the result indicates that the model is suitable for maintainability qualitative evaluation and can support maintainability concurrent design.

  17. The Research Dynamic: A Professional Development Model for Secondary School Science Teachers

    OpenAIRE

    Silverman, Philip M.

    2009-01-01

    This essay summarizes the author's 10 years of experience at the Oklahoma Medical Research Foundation mentoring secondary school science teachers during 8-wk Summer Research Institutes. The summary is presented as a learning model, which we call the research dynamic. This model consists of three interlocked components: specified ignorance, peer interactions, and gateway experiments. Specified ignorance is based on the work of the sociologist Robert K. Merton. It is essentially the art of high...

  18. Agent-based Modelling, a new kind of research

    DEFF Research Database (Denmark)

    Held, Fabian P.; Wilkinson, Ian F.; Marks, Robert E.

    2014-01-01

    We discuss the use of Agent-based Modelling for the development and testing of theories about emergent social phenomena in marketing and the social sciences in general. We address both theoretical aspects about the types of phenomena that are suitably addressed with this approach and practical...

  19. Research and Development of Information Retrieval Models and Their Applications.

    Science.gov (United States)

    Fox, Edward A.

    1989-01-01

    This introduction to a special issue devoted to modeling data, information, and knowledge briefly describes the origins of the papers presented and the topics covered, which include: Boolean logic; probability theory; artificial intelligence; organizing and encoding information and data; and characteristics of users of retrieval systems. (12…

  20. A Model and a Metalanguage for Research on Psychological Counseling

    Science.gov (United States)

    Patton, Michael J.; And Others

    1977-01-01

    A model of two-person interaction in psychological counseling, which is derived from Alfred Schutz's phenomenological theory of social relations, and a computer-assisted metalanguage based on case-grammar theory are presented, and their applicability to the analysis of natural language in counseling is argued. (Author)

  1. A Review of Research on Universal Design Educational Models

    Science.gov (United States)

    Rao, Kavita; Ok, Min Wook; Bryant, Brian R.

    2014-01-01

    Universal design for learning (UDL) has gained considerable attention in the field of special education, acclaimed for its promise to promote inclusion by supporting access to the general curriculum. In addition to UDL, there are two other universal design (UD) educational models referenced in the literature, universal design of instruction (UDI)…

  2. Judgment Research and the Dimensional Model of Personality

    Science.gov (United States)

    Garb, Howard N.

    2008-01-01

    Comments on the original article "Plate tectonics in the classification of personality disorder: Shifting to a dimensional model," by T. A. Widiger and T. J. Trull. The purpose of this comment is to address (a) whether psychologists know how personality traits are currently assessed by clinicians and (b) the reliability and validity of those…

  3. The Research of the Driver Attention Field Modeling

    Directory of Open Access Journals (Sweden)

    Pengfei Tao

    2014-01-01

    Full Text Available For expanding the application scope of car-following, based on the basic idea of the noncontact interaction of the objects in physics, establish an attention field model to describe the driving behavior. Firstly, propose the time distance concept to describe the degree of driver perception to the front one-dimensional space and extend its application range to the two-dimensional space. Secondly, connect the point which has the same time distance to constitute the equipotential line of drivers’ attention field equipotent, and establish a model to describe it. Thirdly, define the effective range of the driver’s psychological field with the feature of the driver’s visual distance range increasing and the angle decreasing. Finally, design the calculation method to collect projection of the object in the psychological field scope and calculate the curve points to determine the object’s intensity of psychological field. Preliminarily build the driving behavior model and use the numerical simulation method to simulate the simple transport scenarios; initially verify the validity of the model.

  4. Building a data sharing model for global genomic research.

    Science.gov (United States)

    Kosseim, Patricia; Dove, Edward S; Baggaley, Carman; Meslin, Eric M; Cate, Fred H; Kaye, Jane; Harris, Jennifer R; Knoppers, Bartha M

    2014-08-11

    Data sharing models designed to facilitate global business provide insights for improving transborder genomic data sharing. We argue that a flexible, externally endorsed, multilateral arrangement, combined with an objective third-party assurance mechanism, can effectively balance privacy with the need to share genomic data globally.

  5. Research on Modeling of Hydropneumatic Suspension Based on Fractional Order

    Directory of Open Access Journals (Sweden)

    Junwei Zhang

    2015-01-01

    Full Text Available With such excellent performance as nonlinear stiffness, adjustable vehicle height, and good vibration resistance, hydropneumatic suspension (HS has been more and more applied to heavy vehicle and engineering vehicle. Traditional modeling methods are still confined to simple models without taking many factors into consideration. A hydropneumatic suspension model based on fractional order (HSM-FO is built with the advantage of fractional order (FO in viscoelastic material modeling considering the mechanics property of multiphase medium of HS. Then, the detailed calculation method is proposed based on Oustaloup filtering approximation algorithm. The HSM-FO is implemented in Matlab/Simulink, and the results of comparison among the simulation curve of fractional order, integral order, and the curve of real experiment prove the feasibility and validity of HSM-FO. The damping force property of the suspension system under different fractional orders is also studied. In the end of this paper, several conclusions concerning HSM-FO are drawn according to analysis of simulation.

  6. Contacts Erosion Modelling Using Ansys Computer Software And Experimental Research

    Directory of Open Access Journals (Sweden)

    Borkowski P.

    2015-06-01

    Full Text Available The paper presents a method of contacts’ erosion modelling by using computer simulation and analyzing heating, melting and evaporation processes, which cause contact erosion due to application of electric arc. Calculations have been conducted using professional ANSYS software which allows for thermal processes simulation and includes phase transitions for Ag, Cu, W metals and Ag-W50 composite.

  7. The Extended Parallel Process Model: Illuminating the Gaps in Research

    Science.gov (United States)

    Popova, Lucy

    2012-01-01

    This article examines constructs, propositions, and assumptions of the extended parallel process model (EPPM). Review of the EPPM literature reveals that its theoretical concepts are thoroughly developed, but the theory lacks consistency in operational definitions of some of its constructs. Out of the 12 propositions of the EPPM, a few have not…

  8. Research on Process-oriented Spatio-temporal Data Model

    Directory of Open Access Journals (Sweden)

    XUE Cunjin

    2016-02-01

    Full Text Available According to the analysis of the present status and existing problems of spatio-temporal data models developed in last 20 years,this paper proposes a process-oriented spatio-temporal data model (POSTDM,aiming at representing,organizing and storing continuity and gradual geographical entities. The dynamic geographical entities are graded and abstracted into process objects series from their intrinsic characteristics,which are process objects,process stage objects,process sequence objects and process state objects. The logical relationships among process entities are further studied and the structure of UML models and storage are also designed. In addition,through the mechanisms of continuity and gradual changes impliedly recorded by process objects,and the modes of their procedure interfaces offered by the customized ObjcetStorageTable,the POSTDM can carry out process representation,storage and dynamic analysis of continuity and gradual geographic entities. Taking a process organization and storage of marine data as an example,a prototype system (consisting of an object-relational database and a functional analysis platform is developed for validating and evaluating the model's practicability.

  9. In vitro models of pancreatic cancer for translational oncology research

    Science.gov (United States)

    Feldmann, Georg; Rauenzahn, Sherri; Maitra, Anirban

    2009-01-01

    Background Pancreatic cancer is a disease of near uniform fatality and the overwhelming majority of patients succumb to their advanced malignancy within a few months of diagnosis. Despite considerable advances in our understanding of molecular mechanisms underlying pancreatic carcinogenesis, this knowledge has not yet been fully translated into clinically available treatment strategies that yield significant improvements in disease free or overall survival. Objective Cell line-based in vitro model systems provide powerful tools to identify potential molecular targets for therapeutic intervention as well as for initial pre-clinical evaluation of novel drug candidates. Here we provide a brief overview of recent literature on cell line-based model systems of pancreatic cancer and their application in the search for novel therapeutics against this vicious disease. Conclusion While in vitro models of pancreatic cancer are of tremendous value for genetic studies and initial functional screenings in drug discovery, they carry several imanent drawbacks and are often poor in predicting therapeutic response in humans. Therefore, in most instances they are successfully exploited to generate hypothesis and identify molecular targets for novel therapeutics, which are subsequently subject to further in-depth characterization using more advanced in vivo model systems and clinical trials. PMID:20160967

  10. Organizational Resilience: The Theoretical Model and Research Implication

    Directory of Open Access Journals (Sweden)

    Xiao Lei

    2017-01-01

    Full Text Available Organizations are all subject to a diverse and ever changing and uncertain environment. Under this situation organizations should develop a capability which can resist the emergency and recover from the disruption. Base on lot of literature, the paper provides the main concept of organizational resilience; construct the primary theoretical model and some implications for management.

  11. Identity Bargaining: A Policy Systems Research Model of Career Development.

    Science.gov (United States)

    Slawski, Carl

    A detailed, general and comprehensive accounting scheme is presented, consisting of nine stages of career development, three major sets of elements contributing to career choice (in terms of personal, cultural and situational roles), and 20 hypotheses relating the separate elements. Implicit in the model is a novel procedure and method for…

  12. A Review of Research on Universal Design Educational Models

    Science.gov (United States)

    Rao, Kavita; Ok, Min Wook; Bryant, Brian R.

    2014-01-01

    Universal design for learning (UDL) has gained considerable attention in the field of special education, acclaimed for its promise to promote inclusion by supporting access to the general curriculum. In addition to UDL, there are two other universal design (UD) educational models referenced in the literature, universal design of instruction (UDI)…

  13. Researches on Object Modeling Technology%OMT技术研究

    Institute of Scientific and Technical Information of China (English)

    白君芬

    2012-01-01

      At present, for the study of object-oriented development methods have become more sophisticated. Among them, the Object Modeling Technique (OMT) has better performance in object-oriented software system modeling.Introduced three models of OMT concepts and OMT elaborated the OMT modeling and design process, fully embodies the the OMT techni⁃cal for most applications, the field of software development to provide a more practical, more efficient guarantee.%  目前,对于面向对象开发方法的研究已日益成熟。其中,对象建模技术(OMT)在面向对象的软件系统建模中具有较好的性能。介绍了OMT概念以及OMT的三种模型,阐述了OMT的建模和设计过程,充分体现了OMT技术为大多数应用领域的软件开发提供了一种更实际、更高效的保证。

  14. Animal models in carotenoids research and lung cancer prevention.

    Science.gov (United States)

    Kim, Jina; Kim, Yuri

    2011-10-01

    Numerous epidemiological studies have consistently demonstrated that individuals who eat more fruits and vegetables (which are rich in carotenoids) and who have higher serum β-carotene levels have a lower risk of cancer, especially lung cancer. However, two human intervention trials conducted in Finland and in the United States have reported contrasting results with high doses of β-carotene supplementation increasing the risk of lung cancer among smokers. The failure of these trials to demonstrate actual efficacy has resulted in the initiation of animal studies to reproduce the findings of these two studies and to elucidate the mechanisms responsible for the harmful or protective effects of carotenoids in lung carcinogenesis. Although these studies have been limited by a lack of animal models that appropriately represent human lung cancer induced by cigarette smoke, ferrets and A/J mice are currently the most widely used models for these types of studies. There are several proposed mechanisms for the protective effects of carotenoids on cigarette smoke-induced lung carcinogenesis, and these include antioxidant/prooxidant effects, modulation of retinoic acid signaling pathway and metabolism, induction of cytochrome P450, and molecular signaling involved in cell proliferation and/or apoptosis. The technical challenges associated with animal models include strain-specific and diet-specific effects, differences in the absorption and distribution of carotenoids, and differences in the interactions of carotenoids with other antioxidants. Despite the problems associated with extrapolating from animal models to humans, the understanding and development of various animal models may provide useful information regarding the protective effects of carotenoids against lung carcinogenesis.

  15. Science dynamics and research production indicators, indexes, statistical laws and mathematical models

    CERN Document Server

    Vitanov, Nikolay K

    2016-01-01

    This book deals with methods to evaluate scientific productivity. In the book statistical methods, deterministic and stochastic models and numerous indexes are discussed that will help the reader to understand the nonlinear science dynamics and to be able to develop or construct systems for appropriate evaluation of research productivity and management of research groups and organizations. The dynamics of science structures and systems is complex, and the evaluation of research productivity requires a combination of qualitative and quantitative methods and measures. The book has three parts. The first part is devoted to mathematical models describing the importance of science for economic growth and systems for the evaluation of research organizations of different size. The second part contains descriptions and discussions of numerous indexes for the evaluation of the productivity of researchers and groups of researchers of different size (up to the comparison of research productivities of research communiti...

  16. In vivo research using early life stage models.

    Science.gov (United States)

    Seabra, Rita; Bhogal, Nirmala

    2010-01-01

    Scientists, for a variety of reasons, need to carry out in vivo research. Since experiments that require the use of adult animals pose various logistical, economical and ethical issues, the use of embryonic and larval forms of some organisms are potentially attractive alternatives. Early life stages are appealing because, in general, large numbers of individuals can be maintained in relatively simple housing, minimising costs, and their use involves fewer legal formalities. With this succinct review, we aim to provide an overview of different biological issues that have been successfully explored with the help of eggs, embryos and larvae from the frog, zebrafish and chicken.

  17. When do researchers collaborate? Toward a model of collaboration propensity in science and engineering research

    Science.gov (United States)

    Birnholtz, Jeremy P.

    Geographically distributed and multidisciplinary collaborations have proven invaluable in answering a range of important scientific questions, such as understanding and controlling disease threats like SARS and AIDS or exploring the nature of matter in particle physics. Despite this, however, collaboration can often be problematic. There are institutional obstacles, collaboration tools may be poorly designed, and group coordination is difficult. To better design technologies to support research activities, we need an improved understanding of why scientists collaborate and how their collaborations work. To achieve this improved understanding, this study compares two theoretical approaches to collaboration propensity---that is, the extent to which collaboration is perceived as useful by individual researchers. On one hand, cultural comparisons of disciplines suggest that collaboration propensity will be higher in disciplinary cultures that have a more collectivist orientation, as indicated by low levels of competition for individual recognition and few concerns about secrecy related to commercialization and intellectual property. In contrast, an approach based on social and organizational psychology suggests that collaboration propensity will vary as a function of resource concentration, fieldwide focus on a well-defined set of problems, and the need for and availability of help when difficult problems are encountered in day-to-day work. To explore this question, a mail survey of 900 academic researchers in three fields was conducted, along with 100 interviews with practicing researchers at 17 sites in the field. Results support a social and organizational psychological interpretation of collaboration propensity. That is, cultural factors such as competition for individual recognition and concerns about intellectual property were not perceived as significant impediments to collaboration. Instead, characteristics like resource concentration and frequent help

  18. Model for Developing Educational Research Productivity: The Medical Education Research Group

    Science.gov (United States)

    Perry, Marcia; Hopson, Laura; House, Joseph B.; Fischer, Jonathan P.; Dooley-Hash, Suzanne; Hauff, Samantha; Wolff, Margaret S.; Sozener, Cemal; Nypaver, Michele; Moll, Joel; Losman, Eve D.; Carney, Michele; Santen, Sally A.

    2015-01-01

    Introduction Education research and scholarship are essential for promotion of faculty as well as dissemination of new educational practices. Educational faculty frequently spend the majority of their time on administrative and educational commitments and as a result educators often fall behind on scholarship and research. The objective of this educational advance is to promote scholarly productivity as a template for others to follow. Methods We formed the Medical Education Research Group (MERG) of education leaders from our emergency medicine residency, fellowship, and clerkship programs, as well as residents with a focus on education. First, we incorporated scholarship into the required activities of our education missions by evaluating the impact of programmatic changes and then submitting the curricula or process as peer-reviewed work. Second, we worked as a team, sharing projects that led to improved motivation, accountability, and work completion. Third, our monthly meetings served as brainstorming sessions for new projects, research skill building, and tracking work completion. Lastly, we incorporated a work-study graduate student to assist with basic but time-consuming tasks of completing manuscripts. Results The MERG group has been highly productive, achieving the following scholarship over a three-year period: 102 abstract presentations, 46 journal article publications, 13 MedEd Portal publications, 35 national didactic presentations and five faculty promotions to the next academic level. Conclusion An intentional focus on scholarship has led to a collaborative group of educators successfully improving their scholarship through team productivity, which ultimately leads to faculty promotions and dissemination of innovations in education. PMID:26594297

  19. Model for Developing Educational Research Productivity: The Medical Education Research Group

    Directory of Open Access Journals (Sweden)

    Marcia Perry

    2015-11-01

    Full Text Available Introduction: Education research and scholarship are essential for promotion of faculty as well as dissemination of new educational practices. Educational faculty frequently spend the majority of their time on administrative and educational commitments and as a result educators often fall behind on scholarship and research. The objective of this educational advance is to promote scholarly productivity as a template for others to follow. Methods: We formed the Medical Education Research Group (MERG of education leaders from our emergency medicine residency, fellowship, and clerkship programs, as well as residents with a focus on education. First, we incorporated scholarship into the required activities of our education missions by evaluating the impact of programmatic changes and then submitting the curricula or process as peer-reviewed work. Second, we worked as a team, sharing projects that led to improved motivation, accountability, and work completion. Third, our monthly meetings served as brainstorming sessions for new projects, research skill building, and tracking work completion. Lastly, we incorporated a workstudy graduate student to assist with basic but time-consuming tasks of completing manuscripts. Results: The MERG group has been highly productive, achieving the following scholarship over a three-year period: 102 abstract presentations, 46 journal article publications, 13 MedEd Portal publications, 35 national didactic presentations and five faculty promotions to the next academic level. Conclusion: An intentional focus on scholarship has led to a collaborative group of educators successfully improving their scholarship through team productivity, which ultimately leads to faculty promotions and dissemination of innovations in education.

  20. The Chemistry CATT-BRAMS model : a regional atmospheric model system for integrated air quality and weather forecasting and research

    National Research Council Canada - National Science Library

    Longo, K. M; Freitas, S. R; Pirre, M; Marécal, V; Rodrigues, L. F; Panetta, J; Alonso, M. F; Rosário, N. E; Moreira, D. S; Gácita, M. S; Arteta, J; Fonseca, R; Stockler, R; Katsurayama, D. M; Fazenda, A; Bela, M

    2013-01-01

    ... (CCATT-BRAMS, version 4.5) is an on-line regional chemical transport model designed for local and regional studies of atmospheric chemistry from the surface to the lower stratosphere suitable both for operational and research purposes...

  1. Long-term Engagement in Authentic Research with NASA (LEARN): Lessons Learned from an Innovative Model for Teacher Research Experiences

    Science.gov (United States)

    Pippin, M. R.; Kollmeyer, R.; Joseph, J.; Yang, M. M.; Omar, A. H.; Harte, T.; Taylor, J.; Lewis, P. M.; Weisman, A.; Hyater-Adams, S.

    2013-12-01

    teachers have changed their ability to communicate the results of research to the public. During this presentation, we will share the LEARN model, findings from the evaluation, and our lessons learned in providing meaningful scientific research experiences for teachers. Our model incorporates intensive support and mentoring, ongoing virtual and face-to-face check-ins, and flexibility to meet teachers' needs on their research projects and in their classrooms.

  2. Research and application of hierarchical model for multiple fault diagnosis

    Institute of Scientific and Technical Information of China (English)

    An Ruoming; Jiang Xingwei; Song Zhengji

    2005-01-01

    Computational complexity of complex system multiple fault diagnosis is a puzzle at all times. Based on the well-known Mozetic's approach, a novel hierarchical model-based diagnosis methodology is put forward for improving efficiency of multi-fault recognition and localization. Structural abstraction and weighted fault propagation graphs are combined to build diagnosis model. The graphs have weighted arcs with fault propagation probabilities and propagation strength. For solving the problem of coupled faults, two diagnosis strategies are used: one is the Lagrangian relaxation and the primal heuristic algorithms; another is the method of propagation strength. Finally, an applied example shows the applicability of the approach and experimental results are given to show the superiority of the presented technique.

  3. Research on Effectiveness Modeling of the Online Chat Group

    Directory of Open Access Journals (Sweden)

    Hua-Fei Zhang

    2013-01-01

    Full Text Available The online chat group is a small-scale multiuser social networking platform, in which users participate in the discussions and send and receive information. Online chat group service providers are concerned about the number of active members because more active members means more advertising revenues. For the group owners and members, efficiency of information acquisition is the concern. So it is of great value to model these two indicators’ impacting factors. This paper deduces the mathematical models of the number of active members and efficiency of information acquisition and then conducts numerical experiment. The experimental results provide evidences about how to improve the number of active members and efficiency of information acquisition.

  4. Research on Trust Propagation Models in Reputation Management Systems

    Directory of Open Access Journals (Sweden)

    Zhiyuan Su

    2014-01-01

    Full Text Available Feedback based reputation systems continue to gain popularity in eCommerce and social media systems today and reputation management in large social networks needs to manage cold start and sparseness in terms of feedback. Trust propagation has been widely recognized as an effective mechanism to handle these problems. In this paper we study the characterization of trust propagation models in the context of attack resilience. We characterize trust propagation models along three dimensions: (i uniform propagation and conditional propagation, (ii jump strategies for breaking unwanted cliques, and (iii decay factors for differentiating recent trust history from remote past history. We formally and experimentally show that feedback similarity is a critical measure for countering colluding attacks in reputation systems. Without feedback similarity guided control, trust propagations are vulnerable to different types of colluding attacks.

  5. The Research of Platform-Based Product Configuration Model

    Science.gov (United States)

    Yan, Huiqiang; Guan, Qunsheng; Li, Qinghai; Lu, Fei; Wang, Xiujuan

    Product configuration system, being a knowledge intensive system, plays an important role in order to realize Mass Customization. The Platform-based generic product configuration tool(PB-GPCT) being developed by Institute of Design for Innovation, Hebei University of Technology. PB-GPCT is a structure-based and domain independent configuration tool. For the realization of PB-GPCT, UML is chosen to construct the configuration model and OCL(Object Constraint Language) to express constraints. In order to manage the constraints of product easily, the approach of checking consistency of configuration model is presented. The theory of constraints hierarchies is introduced into the system of PB-GPCT in order to express customer requirements of different levels.

  6. Basic Research in Digital Stochastic Model Algorithmic Control.

    Science.gov (United States)

    1980-11-01

    Astrom , 1980) approaches. They are, however, not exactly similar since the specification of reference models and the computations of con- trol are done...predictor may be of the state type (Kalman, extended Kalman, etc.), Luenberger observer type, impulse response, or ARMA (Box and Jenkins, 1976 or Astrom ...nonminimum phase systems. Such behavior is not acceptable in applications because of the nonrealizability of infinite inputs ( Astrom , 1970; Astrom and

  7. Research for Future Training Modeling and Simulation Strategies

    Science.gov (United States)

    2011-09-01

    critical new products. Although other portable audio devices existed when Apple introduced the iPod , its design and features were revolutionary and played...the iPod however, Apple cleverly added another part of its business model following the introduction of the device. Within the Apple “closed system...adaptive in meeting user needs by product and service transformations. iii • Apple and IBM provide two well-known business cases to examine as

  8. College English Students’ Autonomous Learning Motivation and Cultivation Model Research

    Institute of Scientific and Technical Information of China (English)

    王艳荣; 李娥

    2015-01-01

    Studying the autonomous learning motivation and excitation model can stimulate intrinsic motivation of foreign language learners,develop students self-management strategy evaluation are very necessary.The purpose of this paper is to give students the skills of listening and speaking for their autonomous learning.Then study the cultivation and motivation of college English students autonomous learning,hoping to make students to learn autonomous learning and stimulate their motivation fully.

  9. Panel: The Future of Research in Modeling & Simulation

    Science.gov (United States)

    2014-12-01

    necessary to replicate a model (Yilmaz 2013). Scientific workflow systems (Anand et al. 2009; Oinn et al. 2004) and provenance-based tracking of...www.sciencemag.org/content/327/5962/144.1.full. Anand, M., S. Bowers, T. McPhillips, and R. Ludascher. 2009. “Exploring Scientific Workflow ...Provenance Using Hybrid Queries over Nested Data and Lineage Graphs.” In Proceedings of the Scientific and Statistical Database Management, 237–254

  10. Structural Equation Modeling: Applications in ecological and evolutionary biology research

    Science.gov (United States)

    Pugesek, Bruce H.; von Eye, Alexander; Tomer, Adrian

    2003-01-01

    This book presents an introduction to the methodology of structural equation modeling, illustrates its use, and goes on to argue that it has revolutionary implications for the study of natural systems. A major theme of this book is that we have, up to this point, attempted to study systems primarily using methods (such as the univariate model) that were designed only for considering individual processes. Understanding systems requires the capacity to examine simultaneous influences and responses. Structural equation modeling (SEM) has such capabilities. It also possesses many other traits that add strength to its utility as a means of making scientific progress. In light of the capabilities of SEM, it can be argued that much of ecological theory is currently locked in an immature state that impairs its relevance. It is further argued that the principles of SEM are capable of leading to the development and evaluation of multivariate theories of the sort vitally needed for the conservation of natural systems. Supplementary information can be found at the authors website, http://www.jamesbgrace.com/. • Details why multivariate analyses should be used to study ecological systems • Exposes unappreciated weakness in many current popular analyses • Emphasizes the future methodological developments needed to advance our understanding of ecological systems.

  11. Mathematical models of physics problems (physics research and technology)

    CERN Document Server

    Anchordoqui, Luis Alfredo

    2013-01-01

    This textbook is intended to provide a foundation for a one-semester introductory course on the advanced mathematical methods that form the cornerstones of the hard sciences and engineering. The work is suitable for first year graduate or advanced undergraduate students in the fields of Physics, Astronomy and Engineering. This text therefore employs a condensed narrative sufficient to prepare graduate and advanced undergraduate students for the level of mathematics expected in more advanced graduate physics courses, without too much exposition on related but non-essential material. In contrast to the two semesters traditionally devoted to mathematical methods for physicists, the material in this book has been quite distilled, making it a suitable guide for a one-semester course. The assumption is that the student, once versed in the fundamentals, can master more esoteric aspects of these topics on his or her own if and when the need arises during the course of conducting research. The book focuses on two cor...

  12. Urban modelling for Budapest using the Weather Research and Forecasting model

    Science.gov (United States)

    Göndöcs, Júlia; Breuer, Hajnalka; Pongrácz, Rita; Bartholy, Judit

    2016-04-01

    The population of Earth is continuously growing, and due to urbanisation it is quite concentrated in metropolitan areas. Overall, cities cover almost 2% of the global surface causing several environmental and social issues. These artificial surface covers significantly modify the surface energy exchange processes through modification of naturally covered lands resulting in altered local wind and temperature patterns because of the presence of buildings. The architectures' three-dimensional extensions certainly affect the incoming radiation, the sky-view factors as well, as the 3D wind fields, resulting in specific local microclimate at each metropolitan area. The increased temperature in the central built-up areas and the cooler surrounding of the cities lead to the urban heat island phenomenon, which is widely studied both with observations and numerical models. The Weather Research and Forecasting (WRF) mesoscale model coupled to multilayer urban canopy parameterisation is used to investigate this phenomenon for Budapest and its surroundings. Before starting the simulations, the detailed surface has to be set up according to the actual conditions, for which CORINE and OpenStreetMap databases are used, both including buildings, different land use categories, and waterbodies. The new land use distribution serving as input for WRF runs distinguishes three urban categories: (i) low-intensity residential, (ii) high-intensity residential, and (iii) commercial/industrial. For the simulations the initial meteorological fields are derived from the publicly available GFS (Global Forecast System) outputs. Simulations are completed for one-week-long periods in summer and winter in 2015, for which we selected periods with the atmospheric conditions of weak wind and clear sky. In order to keep the stability of the simulations, the entire downscaling is carried out in several steps using gradually smaller domains embedded to each other. Thus, three embedded target areas have

  13. Community-Based Participatory Research Conceptual Model: Community Partner Consultation and Face Validity.

    Science.gov (United States)

    Belone, Lorenda; Lucero, Julie E; Duran, Bonnie; Tafoya, Greg; Baker, Elizabeth A; Chan, Domin; Chang, Charlotte; Greene-Moton, Ella; Kelley, Michele A; Wallerstein, Nina

    2016-01-01

    A national community-based participatory research (CBPR) team developed a conceptual model of CBPR partnerships to understand the contribution of partnership processes to improved community capacity and health outcomes. With the model primarily developed through academic literature and expert consensus building, we sought community input to assess face validity and acceptability. Our research team conducted semi-structured focus groups with six partnerships nationwide. Participants validated and expanded on existing model constructs and identified new constructs based on "real-world" praxis, resulting in a revised model. Four cross-cutting constructs were identified: trust development, capacity, mutual learning, and power dynamics. By empirically testing the model, we found community face validity and capacity to adapt the model to diverse contexts. We recommend partnerships use and adapt the CBPR model and its constructs, for collective reflection and evaluation, to enhance their partnering practices and achieve their health and research goals. © The Author(s) 2014.

  14. Life sciences research in space: The requirement for animal models

    Science.gov (United States)

    Fuller, C. A.; Philips, R. W.; Ballard, R. W.

    1987-01-01

    Use of animals in NASA space programs is reviewed. Animals are needed because life science experimentation frequently requires long-term controlled exposure to environments, statistical validation, invasive instrumentation or biological tissue sampling, tissue destruction, exposure to dangerous or unknown agents, or sacrifice of the subject. The availability and use of human subjects inflight is complicated by the multiple needs and demands upon crew time. Because only living organisms can sense, integrate and respond to the environment around them, the sole use of tissue culture and computer models is insufficient for understanding the influence of the space environment on intact organisms. Equipment for spaceborne experiments with animals is described.

  15. Research on Remote Network Bidirectional Detect and Control Model

    Directory of Open Access Journals (Sweden)

    Hongyao Ju

    2013-09-01

    Full Text Available Remote network bidirectional detect and control technologies are the key factors to solve local network allopatry expansibility and management. With studying gateway integration technology, bidirectional VPN technology, identity authentication technology and dynamic host management technology can be integrated into gateway. Thus, bidirectional connect and control among allopatry local networks based on Internet can be solved. Whole area expansibility of local network is realized. With experiment, the model is proved to finish remote bidirectional interconnection of local network automatically and to obtain allopatry local users authority. The equipment detecting and controlling in remote local networks are realized.  

  16. Research on system architecture of modeling and simulation

    Institute of Scientific and Technical Information of China (English)

    WANG Jiangyun; WANG Xingren

    2007-01-01

    The modeling and simulation(M&S)architecture describes and defines the relationship between the difeerent parts of a simulation.The simulation system architecture and simulation support platform architecture are discussed separately.The simulation support platform architecture consists of the management layer,the resource layer,the communication layer,the application layer and the infrastructure layer.The best Wav is to design and realize the M&S collaborative environment for simulation support platform in the resource-communication-application three-dimension space.

  17. Recommended Research Directions for Improving the Validation of Complex Systems Models.

    Energy Technology Data Exchange (ETDEWEB)

    Vugrin, Eric D. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Trucano, Timothy G. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Swiler, Laura Painton [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Finley, Patrick D. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Flanagan, Tatiana Paz [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Naugle, Asmeret Bier [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Tsao, Jeffrey Y. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Verzi, Stephen Joseph [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2017-02-01

    Improved validation for models of complex systems has been a primary focus over the past year for the Resilience in Complex Systems Research Challenge. This document describes a set of research directions that are the result of distilling those ideas into three categories of research -- epistemic uncertainty, strong tests, and value of information. The content of this document can be used to transmit valuable information to future research activities, update the Resilience in Complex Systems Research Challenge's roadmap, inform the upcoming FY18 Laboratory Directed Research and Development (LDRD) call and research proposals, and facilitate collaborations between Sandia and external organizations. The recommended research directions can provide topics for collaborative research, development of proposals, workshops, and other opportunities.

  18. Research on Modelling Digital Paper-cut Preservation

    Institute of Scientific and Technical Information of China (English)

    Xiao-Fen Wang; Ying-Rui Liu; Wen-Sheng Zhang

    2009-01-01

    This paper studies the model of the digital preservation of paper-cut after analyzing the state-of-the-art of the preservation of intangible cultural heritage at home and abroad, focusing on paper-cutting in Hebei, China in a comprehensive approach of sociology, anthropology, folk art, folklore, communication, computer, and information science. Models, methods, and solutions for the preservation and retention of national and folk cultural heritage are proposed. A virtual multimedia interactive system framework of the digital preservation of national and folk cultural heritage is constructed. The standards of paper-cut digitization arc studied. The main content of the paper involves: regulated data collection and recording of the scattered Chinese folk paper-cut works in Hebei; digitization, optimization, compression, classification, icon and pattern extraction, vectorization, and work analysis of the first-hand material. This paper also investigates the demonstration, dissemination, database construction, and retrieval of the classified material, icons, and patterns; the demonstration of the reconstruction and application of icon and pattern database; the design and development of an immersive virtual gaming platform of the multi-media scenes and production process of folk paper-cut.

  19. Simplified Physics Based Models Research Topical Report on Task #2

    Energy Technology Data Exchange (ETDEWEB)

    Mishra, Srikanta; Ganesh, Priya

    2014-10-31

    We present a simplified-physics based approach, where only the most important physical processes are modeled, to develop and validate simplified predictive models of CO2 sequestration in deep saline formation. The system of interest is a single vertical well injecting supercritical CO2 into a 2-D layered reservoir-caprock system with variable layer permeabilities. We use a set of well-designed full-physics compositional simulations to understand key processes and parameters affecting pressure propagation and buoyant plume migration. Based on these simulations, we have developed correlations for dimensionless injectivity as a function of the slope of fractional-flow curve, variance of layer permeability values, and the nature of vertical permeability arrangement. The same variables, along with a modified gravity number, can be used to develop a correlation for the total storage efficiency within the CO2 plume footprint. Similar correlations are also developed to predict the average pressure within the injection reservoir, and the pressure buildup within the caprock.

  20. Research of combined liver-kidney transplantation model in rats

    Institute of Scientific and Technical Information of China (English)

    Jiageng Zhu; Jun Li; Ruipeng Jia; Jianghao Su; Mingshun Shen; Zhigang Cao

    2007-01-01

    Objective: To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods: SD rats served as both donors and recipients. 4℃ sodium lactate Ringer's was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava (IVC) inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results: Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion: This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.

  1. The physical model for research of behavior of grouting mixtures

    Science.gov (United States)

    Hajovsky, Radovan; Pies, Martin; Lossmann, Jaroslav

    2016-06-01

    The paper deals with description of physical model designed for verification of behavior of grouting mixtures when applied below underground water level. Described physical model has been set up to determine propagation of grouting mixture in a given environment. Extension of grouting in this environment is based on measurement of humidity and temperature with the use of combined sensors located within preinstalled special measurement probes around grouting needle. Humidity was measured by combined capacity sensor DTH-1010, temperature was gathered by a NTC thermistor. Humidity sensors measured time when grouting mixture reached sensor location point. NTC thermistors measured temperature changes in time starting from initial of injection. This helped to develop 3D map showing the distribution of grouting mixture through the environment. Accomplishment of this particular measurement was carried out by a designed primary measurement module capable of connecting 4 humidity and temperature sensors. This module also takes care of converting these physical signals into unified analogue signals consequently brought to the input terminals of analogue input of programmable automation controller (PAC) WinPAC-8441. This controller ensures the measurement itself, archiving and visualization of all data. Detail description of a complex measurement system and evaluation in form of 3D animations and graphs is supposed to be in a full paper.

  2. Critical Appraisal of Translational Research Models for Suitability in Performance Assessment of Cancer Centers

    OpenAIRE

    Rajan, Abinaya; Sullivan, Richard; Bakker, Suzanne; van Harten, Wim H.

    2012-01-01

    This study aimed to critically appraise translational research models for suitability in performance assessment of cancer centers. Process models, such as the Process Marker Model and Lean and Six Sigma applications, seem to be suitable for performance assessment of cancer centers. However, they must be thoroughly tested in practice.

  3. Research on Multi-Stage Inventory Model by Markov Decision Process

    Science.gov (United States)

    Rong, Ke

    This paper researched multi-stage inventory system and established limited inventory Markov model, on the other hand it induced DP algorithm of limited inventory Markov model. The results proved that the reorder point of multi-stage inventory system can guarantee demand, and also allows the storage costs to a minimum level in accordance with the above model.

  4. Public Opinion Research as a Basis for Student Learning: A Suggested Teaching Model.

    Science.gov (United States)

    Nickerson, Brian J.

    This paper provides a suggested teaching model enabling students to conduct extensive, hands-on survey research as the basis of part or all of a political science class. The model emphasizes active student learning and development of applied skills. The components of this model can be modified for use in a broad array of undergraduate political…

  5. Revisiting Fixed- and Random-Effects Models: Some Considerations for Policy-Relevant Education Research

    Science.gov (United States)

    Clarke, Paul; Crawford, Claire; Steele, Fiona; Vignoles, Anna

    2015-01-01

    The use of fixed (FE) and random effects (RE) in two-level hierarchical linear regression is discussed in the context of education research. We compare the robustness of FE models with the modelling flexibility and potential efficiency of those from RE models. We argue that the two should be seen as complementary approaches. We then compare both…

  6. Selection mechanisms underlying high impact biomedical research--a qualitative analysis and causal model.

    Directory of Open Access Journals (Sweden)

    Hilary Zelko

    Full Text Available BACKGROUND: Although scientific innovation has been a long-standing topic of interest for historians, philosophers and cognitive scientists, few studies in biomedical research have examined from researchers' perspectives how high impact publications are developed and why they are consistently produced by a small group of researchers. Our objective was therefore to interview a group of researchers with a track record of high impact publications to explore what mechanism they believe contribute to the generation of high impact publications. METHODOLOGY/PRINCIPAL FINDINGS: Researchers were located in universities all over the globe and interviews were conducted by phone. All interviews were transcribed using standard qualitative methods. A Grounded Theory approach was used to code each transcript, later aggregating concept and categories into overarching explanation model. The model was then translated into a System Dynamics mathematical model to represent its structure and behavior. Five emerging themes were found in our study. First, researchers used heuristics or rules of thumb that came naturally to them. Second, these heuristics were reinforced by positive feedback from their peers and mentors. Third, good communication skills allowed researchers to provide feedback to their peers, thus closing a positive feedback loop. Fourth, researchers exhibited a number of psychological attributes such as curiosity or open-mindedness that constantly motivated them, even when faced with discouraging situations. Fifth, the system is dominated by randomness and serendipity and is far from a linear and predictable environment. Some researchers, however, took advantage of this randomness by incorporating mechanisms that would allow them to benefit from random findings. The aggregation of these themes into a policy model represented the overall expected behavior of publications and their impact achieved by high impact researchers. CONCLUSIONS: The proposed

  7. Managing postgraduate research service quality: Developing and assessing a conceptual model

    Directory of Open Access Journals (Sweden)

    Shawn Ramroop

    2013-05-01

    Full Text Available This paper reports on the conceptual development and empirical evaluation of a postgraduate (PG research service quality management model, through conducting an electronic survey among a cohort of master’s and doctorate graduates at one of the top three research universities in South Africa, using specifically developed and validated research instruments.By fitting the data from a sample of 117 graduates to a conceptual model using structural equation modelling, it became evident that the PG research students’ perception of the Organisational Climate for Research (OCR is associated with their perception of the PG Research Service Quality (PGSQUAL, the PG Service Experience (SERVEXP and their perception of their Role (RC. However, no association was found between the students’ perception of the research climate (OCR and their satisfaction (SERVSAT with the research service; the service experience (SERVEXP and postgraduate research service quality (PGSQUAL; service satisfaction (SERVSAT and postgraduate service quality (PGSQUAL.  The aforementioned findings imply that higher education institutions need to create a research climate which is supportive of service quality, and better manage the research climate, so that the PG students are clear about their role, which will eventually translate to a better PG service experience and improved perception of PG service quality.

  8. Empirical research on Kano's model and customer satisfaction.

    Science.gov (United States)

    Lin, Feng-Han; Tsai, Sang-Bing; Lee, Yu-Cheng; Hsiao, Cheng-Fu; Zhou, Jie; Wang, Jiangtao; Shang, Zhiwen

    2017-01-01

    Products are now developed based on what customers desire, and thus attractive quality creation has become crucial. In studies on customer satisfaction, methods for analyzing quality attributes and enhancing customer satisfaction have been proposed to facilitate product development. Although substantial studies have performed to assess the impact of the attributes on customer satisfaction, little research has been conducted that quantitatively calculate the odds of customer satisfaction for the Kano classification, fitting a nonlinear relationship between attribute-level performance and customer satisfaction. In the present study, the odds of customer satisfaction were determined to identify the classification of quality attributes, and took customer psychology into account to suggest how decision-makers should prioritize the allocation of resources. A novel method for quantitatively assessing quality attributes was proposed to determine classification criteria and fit the nonlinear relationship between quality attributes and customer satisfaction. Subsequently, a case study was conducted on bicycle user satisfaction to verify the novel method. The concept of customer satisfaction odds was integrated with the value function from prospect theory to understand quality attributes. The results of this study can serve as a reference for product designers to create attractive quality attributes in their products and thus enhance customer satisfaction.

  9. Empirical research on Kano’s model and customer satisfaction

    Science.gov (United States)

    Lin, Feng-Han; Tsai, Sang-Bing; Lee, Yu-Cheng; Hsiao, Cheng-Fu; Zhou, Jie; Wang, Jiangtao; Shang, Zhiwen

    2017-01-01

    Products are now developed based on what customers desire, and thus attractive quality creation has become crucial. In studies on customer satisfaction, methods for analyzing quality attributes and enhancing customer satisfaction have been proposed to facilitate product development. Although substantial studies have performed to assess the impact of the attributes on customer satisfaction, little research has been conducted that quantitatively calculate the odds of customer satisfaction for the Kano classification, fitting a nonlinear relationship between attribute-level performance and customer satisfaction. In the present study, the odds of customer satisfaction were determined to identify the classification of quality attributes, and took customer psychology into account to suggest how decision-makers should prioritize the allocation of resources. A novel method for quantitatively assessing quality attributes was proposed to determine classification criteria and fit the nonlinear relationship between quality attributes and customer satisfaction. Subsequently, a case study was conducted on bicycle user satisfaction to verify the novel method. The concept of customer satisfaction odds was integrated with the value function from prospect theory to understand quality attributes. The results of this study can serve as a reference for product designers to create attractive quality attributes in their products and thus enhance customer satisfaction. PMID:28873418

  10. Computational and Simulation Modeling of Political Attitudes: The 'Tiger' Area of Political Culture Research

    Directory of Open Access Journals (Sweden)

    Voinea, Camelia Florela

    2016-01-01

    Full Text Available In almost one century long history, political attitudes modeling research has accumulated a critical mass of theory and method. Its characteristics and particularities have often suggested that political attitude approach to political persuasion modeling reveals a strong theoretical autonomy of concept which entitles it to become a new separate discipline of research. Though this did not actually happen, political attitudes modeling research has remained the most challenging area – the “tiger” – of political culture modeling research. This paper reviews the research literature on the conceptual, computational and simulation modeling of political attitudes developed starting with the beginning of the 20th century until the present times. Several computational and simulation modeling paradigms have provided support to political attitudes modeling research. These paradigms and the shift from one to another are briefly presented for a period of time of almost one century. The dominant paradigmatic views are those inspired by the Newtonian mechanics, and those based on the principle of methodological individualism and the emergence of macro phenomena from the individual interactions at the micro level of a society. This period of time is divided in eight ages covering the history of ideas in a wide range of political domains, going from political attitudes to polity modeling. Internal and external pressures for paradigmatic change are briefly explained.

  11. NEAMS-Funded University Research in Support of TREAT Modeling and Simulation, FY15

    Energy Technology Data Exchange (ETDEWEB)

    Dehart, Mark [Idaho National Lab. (INL), Idaho Falls, ID (United States); Mausolff, Zander [Univ. of Florida, Gainesville, FL (United States); Goluoglu, Sedat [Univ. of Florida, Gainesville, FL (United States); Prince, Zach [Texas A & M Univ., College Station, TX (United States); Ragusa, Jean [Texas A & M Univ., College Station, TX (United States); Haugen, Carl [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); Ellis, Matt [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); Forget, Benoit [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); Smith, Kord [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); Alberti, Anthony [Oregon State Univ., Corvallis, OR (United States); Palmer, Todd [Oregon State Univ., Corvallis, OR (United States)

    2015-09-01

    This report summarizes university research activities performed in support of TREAT modeling and simulation research. It is a compilation of annual research reports from four universities: University of Florida, Texas A&M University, Massachusetts Institute of Technology and Oregon State University. The general research topics are, respectively, (1) 3-D time-dependent transport with TDKENO/KENO-VI, (2) implementation of the Improved Quasi-Static method in Rattlesnake/MOOSE for time-dependent radiation transport approximations, (3) improved treatment of neutron physics representations within TREAT using OpenMC, and (4) steady state modeling of the minimum critical core of the Transient Reactor Test Facility (TREAT).

  12. Reptiles: a new model for brain evo-devo research.

    Science.gov (United States)

    Nomura, Tadashi; Kawaguchi, Masahumi; Ono, Katsuhiko; Murakami, Yasunori

    2013-03-01

    Vertebrate brains exhibit vast amounts of anatomical diversity. In particular, the elaborate and complex nervous system of amniotes is correlated with the size of their behavioral repertoire. However, the evolutionary mechanisms underlying species-specific brain morphogenesis remain elusive. In this review we introduce reptiles as a new model organism for understanding brain evolution. These animal groups inherited ancestral traits of brain architectures. We will describe several unique aspects of the reptilian nervous system with a special focus on the telencephalon, and discuss the genetic mechanisms underlying reptile-specific brain morphology. The establishment of experimental evo-devo approaches to studying reptiles will help to shed light on the origin of the amniote brains.

  13. Research of Intrusion Detection Technology and its Formal Modeling

    Directory of Open Access Journals (Sweden)

    PENG Yali

    2009-10-01

    Full Text Available The intrusion detection technology is one of the most important dynamic security technologies, which can be used in the critical security system construction and the basic service protection. Apparently, applying formal specification to the procedure of developing an intrusion detection system can fulfill their security requirement and win the confidence of users of the secured systems. Taking a DDoS intrusion detection system as an example, we establish integrity sub-regular database through analyzing the default characteristics and universal characteristics in communication of DDoS attack, which can guarantee fast and effective detection in each appeared DDoS attack. At the same time, we use the association rules mining algorithm mine new rules and their association pattern to detect the unknown attack, and illustrate how Z can be used to specify and model the security-critical systems.

  14. Research of RFID middleware model with CEP based on SOA

    Science.gov (United States)

    Wang, Zhao; Ma, Zhifeng

    2012-01-01

    RFID middleware is regarded as the nerve of RFID systems. Firstly this paper analysis and discuss relatively mature RFID middleware, and propose a RFID middleware which based on service-oriented architecture. Then in this paper we introduce the CEP (complex event processing), and it is a new technology for event and data processing. With the widespread usage of RFID technology, complex event processing becomes a very important part in RFID application. Through introducing its work, we indicate the basis of introducing CEP to RFID middleware. We focus on the complex event processing technology in RFID data processing, and present a based on CEP data processing model, and study cache, Event Filter and Complex Event Builder key technologies. Moreover, a query language for detecting RFID complex events is also introduced.

  15. Optimization of Glioblastoma Mouse Orthotopic Xenograft Models for Translational Research.

    Science.gov (United States)

    Irtenkauf, Susan M; Sobiechowski, Susan; Hasselbach, Laura A; Nelson, Kevin K; Transou, Andrea D; Carlton, Enoch T; Mikkelsen, Tom; deCarvalho, Ana C

    2017-08-01

    Glioblastoma is an aggressive primary brain tumor predominantly localized to the cerebral cortex. We developed a panel of patient-derived mouse orthotopic xenografts (PDOX) for preclinical drug studies by implanting cancer stem cells (CSC) cultured from fresh surgical specimens intracranially into 8-wk-old female athymic nude mice. Here we optimize the glioblastoma PDOX model by assessing the effect of implantation location on tumor growth, survival, and histologic characteristics. To trace the distribution of intracranial injections, toluidine blue dye was injected at 4 locations with defined mediolateral, anterioposterior, and dorsoventral coordinates within the cerebral cortex. Glioblastoma CSC from 4 patients and a glioblastoma nonstem-cell line were then implanted by using the same coordinates for evaluation of tumor location, growth rate, and morphologic and histologic features. Dye injections into one of the defined locations resulted in dye dissemination throughout the ventricles, whereas tumor cell implantation at the same location resulted in a much higher percentage of small multifocal ventricular tumors than did the other 3 locations tested. Ventricular tumors were associated with a lower tumor growth rate, as measured by in vivo bioluminescence imaging, and decreased survival in 4 of 5 cell lines. In addition, tissue oxygenation, vasculature, and the expression of astrocytic markers were altered in ventricular tumors compared with nonventricular tumors. Based on this information, we identified an optimal implantation location that avoided the ventricles and favored cortical tumor growth. To assess the effects of stress from oral drug administration, mice that underwent daily gavage were compared with stress-positive and -negative control groups. Oral gavage procedures did not significantly affect the survival of the implanted mice or physiologic measurements of stress. Our findings document the importance of optimization of the implantation site for

  16. Enhancing research capacity across healthcare and higher education sectors: development and evaluation of an integrated model

    Directory of Open Access Journals (Sweden)

    Whitworth Anne

    2012-08-01

    Full Text Available Abstract Background With current policy in healthcare research, in the United Kingdom and internationally, focused on development of research excellence in individuals and teams, building capacity for implementation and translation of research is paramount among the professionals who use that research in daily practice. The judicious use of research outcomes and evaluation of best evidence and practice in healthcare is integrally linked to the research capacity and capabilities of the workforce. In addition to promoting high quality research, mechanisms for actively enhancing research capacity more generally must be in place to address the complexities that both undermine and facilitate this activity. Methods A comprehensive collaborative model for building research capacity in one health professional group, speech and language therapy, was developed in a region within the UK and is presented here. The North East of England and the strong research ethos of this profession in addressing complex interventions offered a fertile context for developing and implementing a model which integrated the healthcare and university sectors. Two key frameworks underpin this model. The first addresses the individual participants’ potential trajectory from research consciousness to research participative to research active. The second embeds a model developed for general practitioners into a broader framework of practice-academic partnership and knowledge and skills exchange, and considers external drivers and impacts on practice and patient outcomes as key elements. Results and discussion The integration of practice and academia has been successful in building a culture of research activity within one healthcare profession in a region in the UK and has resulted, to date, in a series of research related outcomes. Understanding the key components of this partnership and the explicit strategies used has driven the implementation of the model and are discussed

  17. Modeling research in low-medium temperature geothermal field, Tianjin

    Institute of Scientific and Technical Information of China (English)

    王坤; 李春华

    2002-01-01

    The geothermal reservoir in Tianjin can be divided into two parts: the upper one is the porous medium reservoir in the Tertiary system; the lower one includes the basement reservoir in Lower Paleozoic and Middle-Upper Proterozoic. Hot springs are exposed in the northern mountain and confined geothermal water is imbedded in the southern plain. The geothermal reservoir is incised by several fractures. In recent years, TDS of the geothermal water have gone up along with the production rate increasing, along the eastern fracture zone (Cangdong Fracture and West Baitangkou Fracture). This means that the northern fracture system is the main seepage channel of the deep circulation geothermal water, and the reservoir has good connection in a certain area and definite direction. The isotopic research about hydrogen and carbon chronology indicates that the main recharge period of geothermal water is the Holocene Epoch, the pluvial and chilly period of 20 kaBP. The karst conduits in weathered carbonate rocks of the Proterozoic and Lower Paleozoic and the northeast regional fracture system are the main feeding channels of Tianjin geothermal water. Since the Holocene epoch, the geothermal water stayed at a sealed warm period. The tracer test in WR45 doublet system shows that the tracer test is a very effective measure for understanding the reservoir's transport nature and predicting the cooling time and transport velocity during the reinjection. 3-D numerical simulation shows that if the reinjection well keeps a suitable distance from the production well, reinjection will be a highly effective measure to extract more thermal energy from the rock matrix. The cooling of the production well will not be a problem.

  18. Global scientific research commons under the Nagoya Protocol: Towards a collaborative economy model for the sharing of basic research assets.

    Science.gov (United States)

    Dedeurwaerdere, Tom; Melindi-Ghidi, Paolo; Broggiato, Arianna

    2016-01-01

    This paper aims to get a better understanding of the motivational and transaction cost features of building global scientific research commons, with a view to contributing to the debate on the design of appropriate policy measures under the recently adopted Nagoya Protocol. For this purpose, the paper analyses the results of a world-wide survey of managers and users of microbial culture collections, which focused on the role of social and internalized motivations, organizational networks and external incentives in promoting the public availability of upstream research assets. Overall, the study confirms the hypotheses of the social production model of information and shareable goods, but it also shows the need to complete this model. For the sharing of materials, the underlying collaborative economy in excess capacity plays a key role in addition to the social production, while for data, competitive pressures amongst scientists tend to play a bigger role.

  19. Research

    African Journals Online (AJOL)

    A possible strategy to influence students' understanding and perception ... researcher in higher education teaching and learning facilitated the data- ..... B. Qualitative content analysis in nursing research: Concepts, procedures and measures.

  20. In vitro psoriasis models with focus on reconstructed skin models as promising tools in psoriasis research.

    Science.gov (United States)

    Desmet, Eline; Ramadhas, Anesh; Lambert, Jo; Van Gele, Mireille

    2017-06-01

    Psoriasis is a complex chronic immune-mediated inflammatory cutaneous disease associated with the development of inflammatory plaques on the skin. Studies proved that the disease results from a deregulated interplay between skin keratinocytes, immune cells and the environment leading to a persisting inflammatory process modulated by pro-inflammatory cytokines and activation of T cells. However, a major hindrance to study the pathogenesis of psoriasis more in depth and subsequent development of novel therapies is the lack of suitable pre-clinical models mimicking the complex phenotype of this skin disorder. Recent advances in and optimization of three-dimensional skin equivalent models have made them attractive and promising alternatives to the simplistic monolayer cultures, immunological different in vivo models and scarce ex vivo skin explants. Moreover, human skin equivalents are increasing in complexity level to match human biology as closely as possible. Here, we critically review the different types of three-dimensional skin models of psoriasis with relevance to their application potential and advantages over other models. This will guide researchers in choosing the most suitable psoriasis skin model for therapeutic drug testing (including gene therapy via siRNA molecules), or to examine biological features contributing to the pathology of psoriasis. However, the addition of T cells (as recently applied to a de-epidermized dermis-based psoriatic skin model) or other immune cells would make them even more attractive models and broaden their application potential. Eventually, the ultimate goal would be to substitute animal models by three-dimensional psoriatic skin models in the pre-clinical phases of anti-psoriasis candidate drugs. Impact statement The continuous development of novel in vitro models mimicking the psoriasis phenotype is important in the field of psoriasis research, as currently no model exists that completely matches the in vivo psoriasis

  1. Guidelines for Developing and Reporting Machine Learning Predictive Models in Biomedical Research: A Multidisciplinary View.

    Science.gov (United States)

    Luo, Wei; Phung, Dinh; Tran, Truyen; Gupta, Sunil; Rana, Santu; Karmakar, Chandan; Shilton, Alistair; Yearwood, John; Dimitrova, Nevenka; Ho, Tu Bao; Venkatesh, Svetha; Berk, Michael

    2016-12-16

    As more and more researchers are turning to big data for new opportunities of biomedical discoveries, machine learning models, as the backbone of big data analysis, are mentioned more often in biomedical journals. However, owing to the inherent complexity of machine learning methods, they are prone to misuse. Because of the flexibility in specifying machine learning models, the results are often insufficiently reported in research articles, hindering reliable assessment of model validity and consistent interpretation of model outputs. To attain a set of guidelines on the use of machine learning predictive models within clinical settings to make sure the models are correctly applied and sufficiently reported so that true discoveries can be distinguished from random coincidence. A multidisciplinary panel of machine learning experts, clinicians, and traditional statisticians were interviewed, using an iterative process in accordance with the Delphi method. The process produced a set of guidelines that consists of (1) a list of reporting items to be included in a research article and (2) a set of practical sequential steps for developing predictive models. A set of guidelines was generated to enable correct application of machine learning models and consistent reporting of model specifications and results in biomedical research. We believe that such guidelines will accelerate the adoption of big data analysis, particularly with machine learning methods, in the biomedical research community.

  2. Applying the cube model to pediatric psychology: development of research competency skills at the doctoral level.

    Science.gov (United States)

    Madan-Swain, Avi; Hankins, Shirley L; Gilliam, Margaux Barnes; Ross, Kelly; Reynolds, Nina; Milby, Jesse; Schwebel, David C

    2012-03-01

    This article considers the development of research competencies in professional psychology and how that movement might be applied to training in pediatric psychology. The field of pediatric psychology has a short but rich history, and experts have identified critical competencies. However, pediatric psychology has not yet detailed a set of research-based competencies. This article initially reviews the competency initiative in professional psychology, including the cube model as it relates to research training. Next, we review and adapt the knowledge-based/foundational and applied/functional research competencies proposed by health psychology into a cube model for pediatric psychology. We focus especially on graduate-level training but allude to its application throughout professional development. We present the cube model as it is currently being applied to the development of a systematic research competency evaluation for graduate training at our medical/clinical psychology doctoral program at the University of Alabama at Birmingham. Based on the review and synthesis of the literature on research competency in professional psychology we propose future initiatives to develop these competencies for the field of pediatric psychology. The cube model can be successfully applied to the development of research training competencies in pediatric psychology. Future research should address the development, implementation, and assessment of the research competencies for training and career development of future pediatric psychologists.

  3. A Theoretical Framework for Physics Education Research: Modeling Student Thinking

    CERN Document Server

    Redish, E F

    2004-01-01

    Education is a goal-oriented field. But if we want to treat education scientifically so we can accumulate, evaluate, and refine what we learn, then we must develop a theoretical framework that is strongly rooted in objective observations and through which different theoretical models of student thinking can be compared. Much that is known in the behavioral sciences is robust and observationally based. In this paper, I draw from a variety of fields ranging from neuroscience to sociolinguistics to propose an over-arching theoretical framework that allows us to both make sense of what we see in the classroom and to compare a variety of specific theoretical approaches. My synthesis is organized around an analysis of the individual's cognition and how it interacts with the environment. This leads to a two level system, a knowledge-structure level where associational patterns dominate, and a control-structure level where one can describe expectations and epistemology. For each level, I sketch some plausible startin...

  4. Advances in ocean modeling for climate change research

    Science.gov (United States)

    Holland, William R.; Capotondi, Antonietta; Holland, Marika M.

    1995-07-01

    An adequate understanding of climate variability and the eventual prediction of climate change are among the most urgent and far-reaching efforts of the scientific community. The climate system is in an ever-changing state with vast impact on mankind in all his activities. Both short and long-term aspects of climate variability are of concern, and the unravelling of "natural" variability from "man-induced" climate change is required to prepare for and ameliorate, if possible, the potentially devastating aspects of such change. In terms of scientific effort, the climate community can be thought of as the union of the disciplinary sciences of meteorology, oceanography, sea ice and glaciology, and land surface processes. Since models are based upon mathematical and numerical constructs, mathematics and computer sciences are also directly involved. In addition, some of the problems of man-induced climate change (release of greenhouse gases, the ozone-hole problem, etc.) are basically chemical in nature, and the expertise of the atmospheric and oceanic chemist is also required. In addition, some part of the response to climate perturbations will arise in the biological world, due to upsetting the balance in the great food web that binds communities together on both the land and the sea. Thus, the problems to be solved are extraordinarily complex and require the efforts of many kinds of scientist.

  5. Research Techniques Made Simple: Skin Carcinogenesis Models: Xenotransplantation Techniques.

    Science.gov (United States)

    Mollo, Maria Rosaria; Antonini, Dario; Cirillo, Luisa; Missero, Caterina

    2016-02-01

    Xenotransplantation is a widely used technique to test the tumorigenic potential of human cells in vivo using immunodeficient mice. Here we describe basic technologies and recent advances in xenotransplantation applied to study squamous cell carcinomas (SCCs) of the skin. SCC cells isolated from tumors can either be cultured to generate a cell line or injected directly into mice. Several immunodeficient mouse models are available for selection based on the experimental design and the type of tumorigenicity assay. Subcutaneous injection is the most widely used technique for xenotransplantation because it involves a simple procedure allowing the use of a large number of cells, although it may not mimic the original tumor environment. SCC cell injections at the epidermal-to-dermal junction or grafting of organotypic cultures containing human stroma have also been used to more closely resemble the tumor environment. Mixing of SCC cells with cancer-associated fibroblasts can allow the study of their interaction and reciprocal influence, which can be followed in real time by intradermal ear injection using conventional fluorescent microscopy. In this article, we will review recent advances in xenotransplantation technologies applied to study behavior of SCC cells and their interaction with the tumor environment in vivo.

  6. Tank bromeliad - a natural model ecosystem for methane cycling research

    Science.gov (United States)

    Martinson, Guntars; Brandt, Franziska; Conrad, Ralf

    2014-05-01

    Tank bromeliads are common epiphytes throughout neotropical forest ecosystems. They are relatively small discrete habitats for terrestrial and aquatic macro- and microorganisms and naturally replicated. Their tanks effectively collect leaf litter and water and harbor a diverse microbial community. Up to several thousands of these tank bromeliads per hectare of tropical forest create a unique wetland ecosystem responsible for significant methane emissions. In a field study in tropical montane forests of southern Ecuador we sampled tank bromeliads of different species, size and canopy height and found that tank water availability controlled community composition of methanogenic archaea, determined by molecular analysis of the archaeal 16S rRNA genes. We set up a greenhouse experiment to investigate drying and re-wetting effects on microbial community composition and methanogenesis. Additionally, we conducted 13-CH-4 and 13-CO-2 labeling studies to investigate potential interaction of plant and microbial metabolism during methane cycling in tank bromeliads. Drying resulted in rapid change of the microbial community composition. The relative abundance of acetoclastic methanogens increased and that of hydrogenotrophic methanogens decreased with decreasing tank water availability confirming our field observations. Labeling studies showed that carbon was released from the plant into the tank supporting methanogenesis and that tank-produced methane was ventilated through the bromeliad leaf structure into the atmosphere which is analogous to the rhizosphere environment of wetland ecosystems. The bromeliad ecosystem may therefore provide a natural model to study how environmental changes and plant-microbe interactions drive methane cycling in aquatic-terrestrial ecosystems.

  7. Flexible global ocean-atmosphere-land system model. A modeling tool for the climate change research community

    Energy Technology Data Exchange (ETDEWEB)

    Zhou, Tianjun; Yu, Yongqiang; Liu, Yimin; Wang, Bin (eds.) [Chinese Academy of Sciences, Beijing, (China). Inst. of Atmospheric Physics

    2014-04-01

    First book available on systematic evaluations of the performance of the global climate model FGOALS. Covers the whole field, ranging from the development to the applications of this climate system model. Provide an outlook for the future development of the FGOALS model system. Offers brief introduction about how to run FGOALS. Coupled climate system models are of central importance for climate studies. A new model known as FGOALS (the Flexible Global Ocean-Atmosphere-Land System model), has been developed by the State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics, Institute of Atmospheric Physics, Chinese Academy of Sciences (LASG/IAP, CAS), a first-tier national geophysical laboratory. It serves as a powerful tool, both for deepening our understanding of fundamental mechanisms of the climate system and for making decadal prediction and scenario projections of future climate change. ''Flexible Global Ocean-Atmosphere-Land System Model: A Modeling Tool for the Climate Change Research Community'' is the first book to offer systematic evaluations of this model's performance. It is comprehensive in scope, covering both developmental and application-oriented aspects of this climate system model. It also provides an outlook of future development of FGOALS and offers an overview of how to employ the model. It represents a valuable reference work for researchers and professionals working within the related areas of climate variability and change.

  8. Ethical guidelines, animal profile, various animal models used in periodontal research with alternatives and future perspectives

    Science.gov (United States)

    Pasupuleti, Mohan Kumar; Molahally, Subramanya Shetty; Salwaji, Supraja

    2016-01-01

    Laboratory animal models serve as a facilitator to investigate the etiopathogenesis of periodontal disease, are used to know the efficacy of reconstructive and regenerative procedures, and are also helpful in evaluation of newer therapeutic techniques including laser and implant therapies prior to application in the human beings. The aim of this review is to know the different animal models used in various specialties of dental research and to know the ethical guidelines prior to the usage of experimental models with main emphasis on how to refine, replace, and reduce the number of animal models usage in the laboratory. An online search for experimental animal models used in dental research was performed using MEDLINE/PubMed database. Publications from 2009 to May 2013 in the specialty of periodontics were included in writing this review. A total of 652 references were published in PubMed/MEDLINE databases based on the search terms used. Out of 245 studies, 241 were related to the periodontal research published in English from 2009 to 2013. Relevant papers were chosen according to the inclusion and exclusion criteria. After extensive electronic and hand search on animal models, it has been observed that various animal models were used in dental research. Search on animal models used for dental research purpose revealed that various animals such as rats, mice, guinea pigs, rabbit, beagle dogs, goats, and nonhuman primates were extensively used. However, with the new advancement of ex vivo animal models, it has become easy to investigate disease pathogenesis and to test the efficacy of newer therapeutic modalities with the reduced usage of animal models. This review summarized the large amount of literature on animal models used in periodontal research with main emphasis on ethical guidelines and on reducing the animal model usage in future perspective. PMID:28298815

  9. Ethical guidelines, animal profile, various animal models used in periodontal research with alternatives and future perspectives

    Directory of Open Access Journals (Sweden)

    Mohan Kumar Pasupuleti

    2016-01-01

    Full Text Available Laboratory animal models serve as a facilitator to investigate the etiopathogenesis of periodontal disease, are used to know the efficacy of reconstructive and regenerative procedures, and are also helpful in evaluation of newer therapeutic techniques including laser and implant therapies prior to application in the human beings. The aim of this review is to know the different animal models used in various specialties of dental research and to know the ethical guidelines prior to the usage of experimental models with main emphasis on how to refine, replace, and reduce the number of animal models usage in the laboratory. An online search for experimental animal models used in dental research was performed using MEDLINE/PubMed database. Publications from 2009 to May 2013 in the specialty of periodontics were included in writing this review. A total of 652 references were published in PubMed/MEDLINE databases based on the search terms used. Out of 245 studies, 241 were related to the periodontal research published in English from 2009 to 2013. Relevant papers were chosen according to the inclusion and exclusion criteria. After extensive electronic and hand search on animal models, it has been observed that various animal models were used in dental research. Search on animal models used for dental research purpose revealed that various animals such as rats, mice, guinea pigs, rabbit, beagle dogs, goats, and nonhuman primates were extensively used. However, with the new advancement of ex vivo animal models, it has become easy to investigate disease pathogenesis and to test the efficacy of newer therapeutic modalities with the reduced usage of animal models. This review summarized the large amount of literature on animal models used in periodontal research with main emphasis on ethical guidelines and on reducing the animal model usage in future perspective.

  10. Research on regional capability constructive models of cleat development mechanism

    Institute of Scientific and Technical Information of China (English)

    Chen Leishan; Liu Qingqiang; Geng Jie; Lu Genfa

    2009-01-01

    Global climate change has been identified as the ftrst of the top ten environmental problems in the world,As climate change will have serious effects on the social and economic development and everyday living of people in the world,many of the countries and governments are taking untiring efforts to combat climate change.As one of the important mechanisms of reducing greenhouse gas (GHG) emissions in the Kyoto Protocol,Clean DevelopmentMechanism (CDM) has not only provided chance.for developed countries to ftdfill greenhouse emission reduction obligations,but also provided an opportunity for developing countries to combat climate change under the sustainabledevelopment frame.The dual objectives of developed countries' GHG emissions' reduction obligation achievement and developing countries'sustainable development will be achieved under the CDM.As a country with responsibility,China has been positively developing CDM projects and promoting energy saving and emissions reduction during the three years after the Kyoto Protocol came into force,and CDM projects development has always been in the front tank in the world However,as the vast clime within China,notable differences occur in different regions.In order to promote the CDM development in China,it is necessary to have regional CDM capability construction in accor dance with the practicality in different regions.Based on the Slat Analysis of developed CDM projects and current CDM development status in China,problems in the CDM development of China,including the inefficiency in sinall and medium-sized CDM Projects development,over centralization of CDM development scope and especially the differentiated provincial CDM projects developing capability are pointed out in the paper.What's more,reasons forthe problems are analyzed from the leading factors,including policy orient,information asymmetry and weak CDMcapability.In order to promote CDM projects development in China,a new CDM capability construction model is put

  11. Building and Researching the Bidding Model Based on the Cost of Power Plant

    Institute of Scientific and Technical Information of China (English)

    秦春申; 叶春; 赵景峰

    2004-01-01

    A bidding model of neural network was presented to pursue the largest benefit according to the policy of separating power plants from network and bidding transaction. This model bases on the cost of power plant and its research object is a power plant in the market. The market clearing price (MCP) can be predicted and an optimized load curve can be decided in this model. The model may provide technical support for the power plant.

  12. Weather Research and Forecasting (WRF) Regional Atmospheric Model: Maui-Oahu

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Weather Research and Forecasting (WRF) mesoscale numerical weather prediction model 7-day hourly forecast for the region surrounding the Hawaiian islands of Oahu,...

  13. Implications of the Situated Learning Model for Teaching and Learning Nursing Research.

    Science.gov (United States)

    Gieselman, Janet A.; Stark, Nola; Farruggia, Michael J.

    2000-01-01

    A situated learning model was applied in a workshop on nursing research in order to provide a multifaceted, engaging learning experience. Techniques used included stories, reflection, cognitive apprenticeship, collaboration, coaching, multiple practice, articulation of learning skills, and technology. (SK)

  14. Scaled Model Technology for Flight Research of General Aviation Aircraft Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Our proposed future Phase II activities are aimed at developing a scientifically based "tool box" for flight research using scaled models. These tools will be of...

  15. The Role of Learning Strategies in Second Language Acquisition: A Model for Research in Listening Comprehension

    Science.gov (United States)

    1987-06-01

    role of learning strategies in second language acquisition . While strategies used in acquiring productive language skills are discussed briefly, the...comprehensions. Keywords: Learning strategies, English as a second language, Second language acquisition , Basic skills, Research model.

  16. Weather Research and Forecasting (WRF) Regional Atmospheric Model: Main Hawaiian Islands

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Weather Research and Forecasting (WRF) mesoscale numerical weather prediction model 7-day hourly forecast for the region surrounding the Main Hawaiian Islands (MHI)...

  17. Analysis of Hurricane Irene’s Wind Field Using the Advanced Research Weather Research and Forecast (WRF-ARW Model

    Directory of Open Access Journals (Sweden)

    Alfred M. Klausmann

    2014-01-01

    Full Text Available Hurricane Irene caused widespread and significant impacts along the U.S. east coast during 27–29 August 2011. During this period, the storm moved across eastern North Carolina and then tracked northward crossing into Long Island and western New England. Impacts included severe flooding from the mid-Atlantic states into eastern New York and western New England, widespread wind damage and power outages across a large portion of southern and central New England, and a major storm surge along portions of the Long Island coast. The objective of this study was to conduct retrospective simulations using the Advanced Research Weather Research and Forecast (WRF-ARW model in an effort to reconstruct the storm’s surface wind field during the period of 27–29 August 2011. The goal was to evaluate how to use the WRF modeling system as a tool for reconstructing the surface wind field from historical storm events to support storm surge studies. The results suggest that, with even modest data assimilation applied to these simulations, the model was able to resolve the detailed structure of the storm, the storm track, and the spatial surface wind field pattern very well. The WRF model shows real potential for being used as a tool to analyze historical storm events to support storm surge studies.

  18. THE MODERN MODELS AND METHODS OF DIAGNOSIS THE RESEARCH ACTIVITY OF ACADEMIC AND PEDAGOGICAL COLLECTIVES

    Directory of Open Access Journals (Sweden)

    Loyko V. I.

    2015-10-01

    Full Text Available The purpose of research – the development of models and methods of multiparametrical diagnostic the research activities of scientific and pedagogical collectives of educational institutions. The problematics of research is improving the quality and productivity (the efficiency of research activities in educational institutions. The problem of research is the question of how to objectively and comprehensively (in a complex diagnose the research activities of scientific and pedagogical collectives? The urgency of solving specified problem is caused by the need to ensuring a close relationship between research, methodological and educational activities in educational institutions. We have also to consider the increasing role of clusters in the Russian economy, cooperation and integration levels (steps a system of continuous education, etc. The authors identified the parameters reflecting significance of research activities of the scientific and the pedagogical collectives for the scientific and educational community (social megaenvironmental. When allocating indicators the authors took into account that science - the social and cultural phenomenon and the social institution, and the most important aspect of the significance of the research activity - in the innovative development of various spheres of human activity. The applied methods of research: mathematical modeling; methods of the theory of graphs, sets and relations; methods of "artificial intelligence" and the multi-parameter analysis of systems; methods of quality control (theory of latent variables. Methodological bases of research: systemic, cultural, competence, metasystem, sociological, qualimetric and synergetic approaches

  19. Application of Gap Model in the Researches of Hotel Services Quality

    Directory of Open Access Journals (Sweden)

    Ivana Blešić

    2011-01-01

    Full Text Available This work presents the research results of the hotel services quality by applying Gap model and SERVQUAL questionnaire. The research was conducted in five health spa centers in the West Morava river valley region during August and September 2008. The reach is aimed at testing of Gap model, i.e. identification of exceptions when the hotel services quality in the observed sample is concerned.

  20. Technical & Entrepreneurial Research Information System: An applied e-model For Sustainable Entrepreneurship Development

    Directory of Open Access Journals (Sweden)

    Dr. Dhrupad Mahtur

    2005-01-01

    Full Text Available This article stresses on the need for an e-application like Technical and Entrepreneurial Research Information System (TERIS, which enables interaction among academia, industry and various agencies related to researchers for sustainable entrepreneurship development. The functional details of the model are also discussed. This article is based on inputs with reference to the state of Rajasthan. However, the model can very well be replicated elsewhere.

  1. Research on Perfusion CT in Rabbit Brain Tumor Model

    Energy Technology Data Exchange (ETDEWEB)

    Ha, Bon Chul; Kwak, Byung Kook; Jung, Ji Sung [Dept. of Diagnostic Radiology, Chung Ang University Hospital, Seoul (Korea, Republic of); Lim, Cheong Hwan; Jung, Hong Ryang [Dept. of Radiological Science, Hanseo University, Seosan (Korea, Republic of)

    2012-06-15

    We investigated the vascular characteristics of tumors and normal tissue using perfusion CT in the rabbit brain tumor model. The VX2 carcinoma concentration of 1 x 10{sup 7} cells/ml(0.1 ml) was implanted in the brain of nine New Zealand white rabbits (weight: 2.4 kg-3.0 kg, mean: 2.6 kg). The perfusion CT was scanned when the tumors were grown up to 5 mm. The tumor volume and perfusion value were quantitatively analyzed by using commercial workstation (advantage windows workstation, AW, version 4.2, GE, USA). The mean volume of implanted tumors was 316{+-}181 mm{sup 3}, and the biggest and smallest volumes of tumor were 497 mm{sup 3} and 195 mm{sup 3}, respectively. All the implanted tumors in rabbits are single-nodular tumors, and intracranial metastasis was not observed. In the perfusion CT, cerebral blood volume (CBV) were 74.40{+-}9.63, 16.8{+-}0.64, 15.24{+-}3.23 ml/100g in the tumor core, ipsilateral normal brain, and contralateral normal brain, respectively (p{<=}0.05). In the cerebral blood flow (CBF), there were significant differences between the tumor core and both normal brains (p{<=}0.05), but no significant differences between ipsilateral and contralateral normal brains (962.91{+-}75.96 vs. 357.82{+-}12.82 vs. 323.19{+-}83.24 ml/100g/min). In the mean transit time (MTT), there were significant differences between the tumor core and both normal brains (p{<=}0.05), but no significant differences between ipsilateral and contralateral normal brains (4.37{+-}0.19 vs. 3.02{+-}0.41 vs. 2.86{+-}0.22 sec). In the permeability surface (PS), there were significant differences among the tumor core, ipsilateral and contralateral normal brains (47.23{+-}25.44 vs. 14.54{+-}1.60 vs. 6.81{+-}4.20 ml/100g/min)(p{<=}0.05). In the time to peak (TTP) were no significant differences among the tumor core, ipsilateral and contralateral normal brains. In the positive enhancement integral (PEI), there were significant differences among the tumor core, ipsilateral and

  2. Industrial and Academic Collaboration: Hybrid Models for Research and Innovation Diffusion

    Science.gov (United States)

    de Freitas, Sara; Mayer, Igor; Arnab, Sylvester; Marshall, Ian

    2014-01-01

    This paper explores how, in the light of global economic downturn and rising student populations, new academic-industrial models for research collaboration based upon specific technological expertise and knowledge can be developed as potential mechanisms for preserving and extending central university research infrastructure. The paper explores…

  3. Argumentation, Dialogue Theory, and Probability Modeling: Alternative Frameworks for Argumentation Research in Education

    Science.gov (United States)

    Nussbaum, E. Michael

    2011-01-01

    Toulmin's model of argumentation, developed in 1958, has guided much argumentation research in education. However, argumentation theory in philosophy and cognitive science has advanced considerably since 1958. There are currently several alternative frameworks of argumentation that can be useful for both research and practice in education. These…

  4. Research Universities for National Rejuvenation and Global Influence: China's Search for a Balanced Model

    Science.gov (United States)

    Postiglione, Gerard A.

    2015-01-01

    The search continues for a Chinese research university model that can balance quality and quantity in research and teaching. This paper argues that finding one depends upon deepening internationalization, defining educational sovereignty, and expanding university autonomy. The paper does this by examining selected aspects in the development of the…

  5. The Very Best of the Millennium: Longitudinal Research and the Demand-Control-(Support) Model

    NARCIS (Netherlands)

    Lange, A.H.de; Taris, T.W.; Kompier, M.A.J.; Houtman, I.L.D.; Bongers, P.M.

    2003-01-01

    This study addressed the methodological quality of longitudinal research examining R. Karasek and T. Theorell's (1990) demand-control-(support) model and reviewed the results of the best of this research. Five criteria for evaluating methodological quality were used: type of design, length of time l

  6. Research Universities for National Rejuvenation and Global Influence: China's Search for a Balanced Model

    Science.gov (United States)

    Postiglione, Gerard A.

    2015-01-01

    The search continues for a Chinese research university model that can balance quality and quantity in research and teaching. This paper argues that finding one depends upon deepening internationalization, defining educational sovereignty, and expanding university autonomy. The paper does this by examining selected aspects in the development of the…

  7. Industrial and Academic Collaboration: Hybrid Models for Research and Innovation Diffusion

    Science.gov (United States)

    de Freitas, Sara; Mayer, Igor; Arnab, Sylvester; Marshall, Ian

    2014-01-01

    This paper explores how, in the light of global economic downturn and rising student populations, new academic-industrial models for research collaboration based upon specific technological expertise and knowledge can be developed as potential mechanisms for preserving and extending central university research infrastructure. The paper explores…

  8. University-Industry Research Collaboration: A Model to Assess University Capability

    Science.gov (United States)

    Abramo, Giovanni; D'Angelo, Ciriaco Andrea; Di Costa, Flavia

    2011-01-01

    Scholars and policy makers recognize that collaboration between industry and the public research institutions is a necessity for innovation and national economic development. This work presents an econometric model which expresses the university capability for collaboration with industry as a function of size, location and research quality. The…

  9. Using multilevel modeling and mixed methods to make theoretical progress in microfoundations for strategy research

    OpenAIRE

    Aguinis, Herman; Molina-Azorín, José F.

    2015-01-01

    The microfoundations research agenda presents an expanded theoretical perspective because it considers individuals, their characteristics, and their interactions as relevant variables to help us understand firm-level strategic issues. However, microfoundations empirical research faces unique challenges because processes take place at different levels of analysis and these multilevel processes must be considered simultaneously. We describe multilevel modeling and mixed methods as methodologica...

  10. Value-Added Model (VAM) Research for Educational Policy: Framing the Issue

    Science.gov (United States)

    Amrein-Beardsley, Audrey; Collins, Clarin; Polasky, Sarah A.; Sloat, Edward F.

    2013-01-01

    In this manuscript, the guest editors of the EPAA Special Issue on "Value-Added Model (VAM) Research for Educational Policy" (1) introduce the background and policy context surrounding the increased use of VAMs for teacher evaluation and accountability purposes across the United States; (2) summarize the five research papers and one…

  11. A Sustainable Model for Integrating Current Topics in Machine Learning Research into the Undergraduate Curriculum

    Science.gov (United States)

    Georgiopoulos, M.; DeMara, R. F.; Gonzalez, A. J.; Wu, A. S.; Mollaghasemi, M.; Gelenbe, E.; Kysilka, M.; Secretan, J.; Sharma, C. A.; Alnsour, A. J.

    2009-01-01

    This paper presents an integrated research and teaching model that has resulted from an NSF-funded effort to introduce results of current Machine Learning research into the engineering and computer science curriculum at the University of Central Florida (UCF). While in-depth exposure to current topics in Machine Learning has traditionally occurred…

  12. Longitudinal Data Analysis with Latent Growth Modeling: An Introduction and Illustration for Higher Education Researchers

    Science.gov (United States)

    Blanchard, Rebecca D.; Konold, Timothy R.

    2011-01-01

    This paper introduces latent growth modeling (LGM) as a statistical method for analyzing change over time in latent, or unobserved, variables, with particular emphasis of the application of this method in higher education research. While increasingly popular in other areas of education research and despite a wealth of publicly-available datasets…

  13. An Analysis of Academic Research Libraries Assessment Data: A Look at Professional Models and Benchmarking Data

    Science.gov (United States)

    Lewin, Heather S.; Passonneau, Sarah M.

    2012-01-01

    This research provides the first review of publicly available assessment information found on Association of Research Libraries (ARL) members' websites. After providing an overarching review of benchmarking assessment data, and of professionally recommended assessment models, this paper examines if libraries contextualized their assessment…

  14. Using multilevel modeling and mixed methods to make theoretical progress in microfoundations for strategy research

    OpenAIRE

    Aguinis, Herman; Molina-Azorín, José F.

    2015-01-01

    The microfoundations research agenda presents an expanded theoretical perspective because it considers individuals, their characteristics, and their interactions as relevant variables to help us understand firm-level strategic issues. However, microfoundations empirical research faces unique challenges because processes take place at different levels of analysis and these multilevel processes must be considered simultaneously. We describe multilevel modeling and mixed methods as methodologica...

  15. A Sustainable Model for Integrating Current Topics in Machine Learning Research into the Undergraduate Curriculum

    Science.gov (United States)

    Georgiopoulos, M.; DeMara, R. F.; Gonzalez, A. J.; Wu, A. S.; Mollaghasemi, M.; Gelenbe, E.; Kysilka, M.; Secretan, J.; Sharma, C. A.; Alnsour, A. J.

    2009-01-01

    This paper presents an integrated research and teaching model that has resulted from an NSF-funded effort to introduce results of current Machine Learning research into the engineering and computer science curriculum at the University of Central Florida (UCF). While in-depth exposure to current topics in Machine Learning has traditionally occurred…

  16. Bridging Design and Behavioral Research With Variance-Based Structural Equation Modeling

    NARCIS (Netherlands)

    Henseler, Jörg

    2017-01-01

    Advertising research is a scientific discipline that studies artifacts (e.g., various forms of marketing communication) as well as natural phenomena (e.g., consumer behavior). Empirical advertising research therefore requires methods that can model design constructs as well as behavioral constructs,

  17. Sprouting Buds of Zebrafish Research in Malaysia: First Malaysia Zebrafish Disease Model Workshop.

    Science.gov (United States)

    Okuda, Kazuhide Shaun; Tan, Pei Jean; Patel, Vyomesh

    2016-04-01

    Zebrafish is gaining prominence as an important vertebrate model for investigating various human diseases. Zebrafish provides unique advantages such as optical clarity of embryos, high fecundity rate, and low cost of maintenance, making it a perfect complement to the murine model equivalent in biomedical research. Due to these advantages, researchers in Malaysia are starting to take notice and incorporate the zebrafish model into their research activities. However, zebrafish research in Malaysia is still in its infancy stage and many researchers still remain unaware of the full potential of the zebrafish model or have limited access to related tools and techniques that are widely utilized in many zebrafish laboratories worldwide. To overcome this, we organized the First Malaysia Zebrafish Disease Model Workshop in Malaysia that took place on 11th and 12th of November 2015. In this workshop, we showcased how the zebrafish model is being utilized in the biomedical field in international settings as well as in Malaysia. For this, notable international speakers and those from local universities known to be carrying out impactful research using zebrafish were invited to share some of the cutting edge techniques that are used in their laboratories that may one day be incorporated in the Malaysian scientific community.

  18. The advisory working alliance and research training: test of a relational efficacy model.

    Science.gov (United States)

    Morrison, M Ashley; Lent, Robert W

    2014-10-01

    Relatively little research attention has been devoted to understanding the mechanisms through which the advising relationship functions as a medium for fostering doctoral students' development as researchers. Adapting Lent and Lopez's (2002) model of relational efficacy, we examined three types of efficacy beliefs (self-efficacy, other-efficacy, and relation-inferred self-efficacy) in relation to the advisory working alliance and the prediction of doctoral students' research interest and productivity. Gelso's (1993) concept of the research training environment was also included in model testing to capture a view of the advisory relationship as existing within a larger program training context. Participants were 274 doctoral students in a variety of academic fields. The results suggested that a slightly revised version of the hypothesized model produced good fit to the data. In particular, controlling for year in the graduate program, we found the advisory working alliance was linked to students' research self-efficacy indirectly via relation-inferred self-efficacy (i.e., students' beliefs about how their advisors viewed their research capabilities). Students' self-efficacy was, in turn, predictive of their interest in and productivity at research. We discuss the implications of these findings for future research and the practice of advising and research training. PsycINFO Database Record (c) 2014 APA, all rights reserved.

  19. Developing a multidisciplinary model of comparative effectiveness research within a clinical and translational science award.

    Science.gov (United States)

    Marantz, Paul R; Strelnick, A Hal; Currie, Brian; Bhalla, Rohit; Blank, Arthur E; Meissner, Paul; Selwyn, Peter A; Walker, Elizabeth A; Hsu, Daphne T; Shamoon, Harry

    2011-06-01

    The Clinical and Translational Science Awards (CTSAs) were initiated to improve the conduct and impact of the National Institutes of Health's research portfolio, transforming training programs and research infrastructure at academic institutions and creating a nationwide consortium. They provide a model for translating research across disciplines and offer an efficient and powerful platform for comparative effectiveness research (CER), an effort that has long struggled but enjoys renewed hope under health care reform. CTSAs include study design and methods expertise, informatics, and regulatory support; programs in education, training, and career development in domains central to CER; and programs in community engagement.Albert Einstein College of Medicine of Yeshiva University and Montefiore Medical Center have entered a formal partnership that places their CTSA at a critical intersection for clinical and translational research. Their CTSA leaders were asked to develop a strategy for enhancing CER activities, and in 2010 they developed a model that encompasses four broadly defined "compartments" of research strength that must be coordinated for this enterprise to succeed: evaluation and health services research, biobehavioral research and prevention, efficacy studies and clinical trials, and social science and implementation research.This article provides historical context for CER, elucidates Einstein-Montefiore's CER model and strategic planning efforts, and illustrates how a CTSA can provide vision, leadership, coordination, and services to support an academic health center's collaborative efforts to develop a robust CER portfolio and thus contribute to the national effort to improve health and health care.

  20. Model Attitude and Deformation Measurements at the NASA Glenn Research Center

    Science.gov (United States)

    Woike, Mark R.

    2008-01-01

    The NASA Glenn Research Center is currently participating in an American Institute of Aeronautics and Astronautics (AIAA) sponsored Model Attitude and Deformation Working Group. This working group is chartered to develop a best practices document dealing with the measurement of two primary areas of wind tunnel measurements, 1) model attitude including alpha, beta and roll angle, and 2) model deformation. Model attitude is a principle variable in making aerodynamic and force measurements in a wind tunnel. Model deformation affects measured forces, moments and other measured aerodynamic parameters. The working group comprises of membership from industry, academia, and the Department of Defense (DoD). Each member of the working group gave a presentation on the methods and techniques that they are using to make model attitude and deformation measurements. This presentation covers the NASA Glenn Research Center s approach in making model attitude and deformation measurements.