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Sample records for kanagawa hiroshi hencho

  1. Special issue: Terrestrial fluids, earthquakes and volcanoes: The Hiroshi Wakita volume I

    Science.gov (United States)

    Perez, Nemesio M.; King, Chi-Yu; Gurrieri, Sergio; McGee, Kenneth A.

    2006-01-01

    Terrestrial Fluids, Earthquakes and Volcanoes: The Hiroshi Wakita Volume I is a special publication to honor Professor Hiroshi Wakita for his scientific contributions. This volume consists of 17 original papers dealing with various aspects of the role of terrestrial fluids in earthquake and volcanic processes, which reflect Prof. Wakita’s wide scope of research interests.Professor Wakita co-founded the Laboratory for Earthquake Chemistry in 1978 and served as its director from 1988 until his retirement from the university in 1997. He has made the laboratory a leading world center for studying earthquakes and volcanic activities by means of geochemical and hydrological methods. Together with his research team and a number of foreign guest researchers that he attracted, he has made many significant contributions in the above-mentioned scientific fields of interest. This achievement is a testimony to not only his scientific talent, but also his enthusiasm, his open mindedness, and his drive in obtaining both human and financial support.

  2. Imaging the Rural: Modernity and Agrarianism in Hiroshi Hamaya’s ‘Snow Land’ Photographs

    Directory of Open Access Journals (Sweden)

    Ross Tunney

    2015-06-01

    Full Text Available This article analyses the Snow Land photographic series by Japanese photographer Hiroshi Hamaya [1915–1999] in relation to issues of modernity, nostalgia and discourses of agrarianism in 1940s and 1950s Japan. Hamaya is one of Japan’s most celebrated and influential documentary photographers at both a national and international level. His Snow Land series presents an idyllic view of life in the small mountain villages of Japan’s Niigata Prefecture, emphasising a sense of community and spiritual meaning that Hamaya perceived to be lacking in modern society. In this sense, Snow Land constituted a critique of modernity. Through engagement with theorists such as Heidegger, Foucault and Barthes, as well as critical writings on agrarian ideology, this article investigates the underlying assumptions that govern Hamaya’s depiction of snow country, demonstrating that the series is shaped by a modern worldview and is tied to ideological discourses of agrarianism.

  3. Insufficiency of the Kanagawa hemolytic test for detecting pathogenic Vibrio parahaemolyticus in Shanghai, China.

    Science.gov (United States)

    Hongping, Wang; Jilun, Zhang; Ting, Jiang; Yixi, Bao; Xiaoming, Zhou

    2011-01-01

    We evaluated the Kanagawa hemolytic test and tdh gene test for accuracy in identifying pathogenic Vibrio parahaemolyticus isolates in Shanghai. One hundred and seventy-two V. parahaemolyticus isolates were collected from diarrhea patients, freshly harvested sea fish, or fresh water samples. Statistical data for the Kanagawa hemolytic test and tdh gene test were compared. There were 83.51% isolates (81/97) from patients and 22.22% isolates (10/45) from sea-fish positive for the tdh gene. However, none of 30 isolates from fresh water samples were tdh-positive. Positive Kanagawa hemolytic tests were obtained in 88.66%, 46.67%, and 76.67% of isolates, which were from patients, sea fish, and fresh water samples, respectively. Positive rates of the Kanagawa hemolytic tests and the tdh gene tests were significantly different in isolates from those 3 sources (P tdh gene test showed higher specificity than the Kanagawa hemolytic test on identifying pathogenic V. parahaemolyticus isolates in Shanghai, China.

  4. Incidence of pests and viral disease on pepino (Solanum muricatum Ait.) in Kanagawa Prefecture, Japan

    Science.gov (United States)

    Kim, Ok-Kyung; Yamada, Yoshihiro; Sato, Takuma; Shinohara, Hirosuke; Takahata, Ken

    2017-01-01

    Abstract Background The solanaceous fruit crop pepino (Solanum muricatum Ait.), originating in the Andes, is grown commercially in South American countries and New Zealand. In these areas, pests and diseases of pepino have been identified well; however, to date, these have seldom been investigated in detail in Japan. Herein, we attempt to reconstruct an agricultural production system for commercial pepino crops in Japan, and evaluate the incidence of pests and viral diseases on pepino. The findings of this study will facilitate in developing a better crop system for the commercial cultivation of healthy pepino fruits. New information A total of 11 species, comprising nine insects and two mites, were recognized as pests of pepino plants in our experimental fields in Kanagawa Prefecture, central Honshu, Japan. Of these pest species, the two-spotted spider mite Tetranychus urticae Koch, 1836 and the cotton aphid Aphis gossypii Glover, 1877, were remarkably abundant than the other pest species. Eventually, 13 species, including two previously recorded, are currently recognized as the pests of pepino in Japan. With regard to viruses, we tested two species Alfalfa mosaic virus (AMV) and Cucumber mosaic virus (CMV), as well as three genera Carlavirus, Potexvirus, and Potyvirus. No virus was detected in symptomatic pepino leaves collected in our experimental fields. This is a first report on the identification of pests on pepino plants in Kanagawa Prefecture, Japan and elucidates the relationship between currently occurring pests of pepino plants and potential viral pathogens that they can transmit. PMID:28947875

  5. Dr Hiroshi Ikukawa Director Planning and Evaluation Division Science and Technology Policy Bureau Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan and Mr Robert Aymar signed an accord for the CERN.

    CERN Document Server

    Claudia Marcelloni

    2007-01-01

    Dr Hiroshi Ikukawa Director Planning and Evaluation Division Science and Technology Policy Bureau Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan and Mr Robert Aymar signed an accord for the CERN.

  6. An Institutional Analysis of Groundwater Quality Control: Experiences in Hadano, Kanagawa Prefecture, Japan

    Directory of Open Access Journals (Sweden)

    Takahiro Endo

    2016-05-01

    Full Text Available A considerable number of studies have been made of institutional arrangements that can prevent excessive groundwater pumping based on Hardin’s seminal work, the “tragedy of the commons.” In contrast, this paper is concerned with groundwater quality control for which policy studies are very limited. This paper not only clarifies institutional challenges specific to groundwater contamination, but also demonstrates how government and industry could solve them using a case study of Hadano, Kanagawa Prefecture, Japan, which has pioneered countermeasures for groundwater pollution in Japan. Hadano solved the challenges by enacting an innovative local ordinance with three pillars: Proxy purification by the city government, fundraising for purification activities and a retroactive system. Lessons learnt from the Hadano case will be very useful to policy makers because these problems already occur in other urban areas, or are likely to occur in the near future.

  7. Indices using external measurements for assessing fat deposition of adult feral raccoons (Procyon lotor) in Kanagawa Prefecture, Japan.

    Science.gov (United States)

    Kato, Takuya; Uno, Taiki; Fujioka, Yoshiyuki; Hayama, Shin-Ichi

    2012-02-01

    We examined the use of external measurements and relative fat deposition of adult feral raccoons (Procyon lotor) to develop relative indices of body fat deposition in post-growth feral raccoons. From March 2006 to March 2010, 288 adult raccoon carcasses (110 males, 178 females) collected in Kanagawa Prefecture, Japan, which were determined to be 24 months old, were subjected to external measurements of body weight (BW), girth measurement (GM), and body mass index (BMI). To assess relative body fat deposition, we visually classified abdominal subcutaneous fat into three grades (Visible Fat Index [VFI]: I-III). Significant differences in the means of BW (both sexes:Praccoons in Kanagawa Prefecture and may be generalizable to populations in other areas.

  8. Report of radioactivity survey in Kanagawa Prefecture, in 1996; Kanagawaken ni okeru hoshanochosa hokokusho, 1996

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-03-01

    This report summarizes the results of 1-year survey on the radioactivities in foods and environments in Kanagawa Prefecture and the uranium level in the surroundings of Japan Nuclear Fuel Co., Ltd. (JNF), a nuclear fuel processing plant. The survey of radioactivity or radiation level was made in environments and foods including rain water, tap water, agricultural and livestock products, marine products, etc. For these subjects, analysis of nuclides and determination of spatial radiation dose rate were performed using {gamma}-ray spectrometer. Only for rain water, the general {beta} level was also determined. The uranium levels was monitored in river water and bottom materials, soil, Undaria pinnatifida, a seagrass in river mouths, etc. The present results show that there was no problem for all subjects tested in respect of radioactivity. And the uranium level around JNF was also within the normal range. The mean intake of {sup 137}Cs was 0.085 Bq/Kg/day for the residents in the district of Hiratsuka Health Center and 0.077 Bq/Kg/day for those in the Yokohama city. Both levels were slightly higher than the previous ones. The survey results before and after the returns of nuclear powered ship were also within the normal range. (M.N.)

  9. Prediction of Female Breast Cancer Incidence among the Aging Society in Kanagawa, Japan

    Science.gov (United States)

    Katayama, Kayoko

    2016-01-01

    Owing to the increasing number of elderly “baby boomers” in Japan, the number of cancer patients is also expected to increase. Approximately 2 million baby boomers from nearby local areas are residing in metropolitan areas; hence, the geographical distribution of cancer patients will probably markedly change. We assessed the expected number of breast cancer (BC) patients in different regions (urban, outer city, town, rural) using estimates of the nation’s population and Kanagawa Cancer Registry data. To estimate future BC incidence for each region, we multiplied the 2010 rate by the predicted female population for each region according to age group. The incidence cases of BC in those aged ≥65 years is expected to increase in all areas; in particular, compared to rates in 2010, the BC incidence in urban areas was predicted to increase by 82.6% in 2035 and 102.2% in 2040. Although the incidence in all BC cases in urban areas showed an increasing trend, until peaking in 2040 (increasing 31.2% from 2010), the number of BC patients would continue to decrease in other areas. The number of BC patients per capita BC specialist was 64.3 patients in 2010; this value would increase from 59.3 in 2010 to 77.7 in 2040 in urban areas, but would decrease in other areas. Our findings suggest that the number of elderly BC patients is expected to increase rapidly in urban areas and that the demand for BC treatment would increase in the elderly population in urban areas. PMID:27532126

  10. Mange caused by Sarcoptes scabiei (Acari: Sarcoptidae) in wild raccoon dogs, Nyctereutes procyonoides, in Kanagawa Prefecture, Japan.

    Science.gov (United States)

    Takahashi, M; Nogami, S; Misumi, H; Maruyama, S; Shiibashi, T; Yamamoto, Y; Sakai, T

    2001-04-01

    Parasitological and histopathological examinations were performed in 25 raccoon dogs (Nyctereutes procyonoides) obtained in Kanagawa Prefecture, Japan, all of which were found to be heavily infected with Sarcoptes scabiei. The mites detected on these raccoon dogs were morphologically indistinguishable from the human species, and no Demodex mites were detected. Histopathological examinations showed prominent hyperkeratosis and acanthosis with eczema, and numerous burrows containing mites were observed in the epidermis. The enzootic dermatitis of wild raccoon dogs in recent years was clearly demonstrated to be caused by S. scabiei in the present study.

  11. Kozu-Matsuda fault system in northern Izu collision zone, western part of Kanagawa Prefecture, central Japan

    Science.gov (United States)

    Odawara, K.; Aketagawa, T.; Yoshida, A.

    2010-12-01

    Western area of Kanagawa Prefecture is techtonically highlighted by its geological setting that the Izu-Bonin volcanic arc collides with the Japan Island arc there. The Kozu-Matsuda fault system which consists of the Kozu-Matsuda fault, the Matsuda-kita fault, the Hinata fault and the Hirayama fault is a surface manifestation of the plate boundary. Research of the Kozu-Matsuda fault has advanced dramatically after the 1995 Kobe Earthquake. Having conducted a trench survey, Kanagawa Prefectural Government (2004) reported that the Kozu-Matsuda fault was activated at least four times in the past 4000 years and the latest activity occurred 650-950 years ago (AD. 1350-1050). However, details of the activity of the Hinata and Hirayama faults, the northern extension of the Kozu-Matsuda fault, are not well understood. The Special Project for Earthquake Disaster Mitigation in Urban areas (DaiDaiToku) made a 2040 m deep drilling in 2004 in Yamakita Town (Hayashi et al., 2006). DaiDaiToku also carried out the seismic reflection profiling along a route from Odawara to Yamanashi in 2005 (Sato et al., 2005). The study done by DaiDaiToku elucidated presence of two north-dipping thrusts. The northern thrust corresponds to the Hinata fault, and the southern one which is also considered to be a continuation of the Kozu-Matsuda fault probably represents a frontal thrust (Miyauchi et al., 2006). We have conducted paleoseismic investigations using data from boreholes across these thrusts.

  12. [A survey of utilization of and problems with the MSDS in chemical substances management at workplaces in Kanagawa Prefecture].

    Science.gov (United States)

    Koshi, Kimiko; Mouri, Tetuo; Sugimori, Hiroki; Numano, Takashi; Ashida, Toshifumi; Hiro, Hisanori; Miyake, Hitoshi; Fukushima, Michiko; Ishiwata, Kouichi

    2002-09-01

    Kanagawa Occupational Health Promotion Center conducted a survey on how the MSDS is utilized at workplaces with more than 50 employees handling chemical substances, and what measures are taken to help employees to thoroughly understand information in the Material Safety Data Sheet (MSDS). Questionnaires were sent out to 265 enterprises in Kanagawa prefecture, putting questions to industrial physicians and industrial hygiene supervisors. The objective of the survey was to find out how MSDS is adopted in the system to manage occupational health, what improvements the survey respondents want in MSDS and what expectations the respondents have of our center. 193 enterprises (72.8%) returned answers to the questionnaire. The major findings are as follows. (1) In many companies, information on hazardous/toxic materials is "controlled by a division using such materials", and roughly half of the companies have compiled a common list shared throughout the company. (2) For the most part suppliers submit to the MSDS. Larger companies have a higher rate of posting up or filing the MSDS at their workplaces. Only 25.8% of the companies "rewrite the MSDS so that workers can understand it." (3) Companies that carry out a hazard/toxicity assessment before introducing a new chemical substance account for 72.1%, which is higher than we expected. It indicates that even though the companies don't manage the MSDS adequately, they are highly concerned about hazard control of chemical substances. (4) The rate of answering that "the current MSDS is not easy to understand" is higher among large-sized enterprises and lower among enterprises with fewer than 300 employees. (5) Asked what improvement needs to be made on the MSDS, the industrial physicians and industrial hygiene supervisors gave same answers such as "Workers find the terminology difficult to understand." and "Levels of toxicity can't be clearly identified." (6) The respondents expect our center to provide information for the MSDS

  13. Hanazonobashi facilities control system. Centralized SCADA for metropolitan express-way; Shutokosokudoro koden Kanagawa kanribudono osame. Hanazonokyo shisetsu kanri system

    Energy Technology Data Exchange (ETDEWEB)

    Higashino, K.; Imai, K.; Kitaura, M.; Kayama, C.; Tsujita, H. [Nisshin Electric Co. Ltd., Kyoto (Japan)

    1996-03-29

    This paper introduces the centralized SCADA system in the express-way line of whole Kanagawa region, which can control various facilities, such as power receiving, distribution and switch facilities, pump houses, transformer towers, and lighting facilities for bridges. The system was designed so as to monitor the whole of the Wangan line to be extended in the future. It consists of a central facility control station (CS) and local control stations (LS). The CS can control the whole facilities and the LS have control functions of start/stop for individual facilities at the maintenance and inspection of the CS. The SCADA system is surpassing in the operability of a huge amount of information, information exchange with other control systems and disaster preventing systems, and the extendability and maintainability. It is a distributed computer control system and also a multi-window type highly functional man-machine system. Multiple projection type large displays were employed to use information in common among operators. To support the facility maintenance works effectively, a data base has been made for collective control of information including drawings, facilities registers, and manual books. 9 figs., 1 tab.

  14. Occurrence of urease-positive Vibrio parahaemolyticus in Kanagawa, Japan, with specific reference to presence of thermostable direct hemolysin (TDH) and the TDH-related-hemolysin genes.

    Science.gov (United States)

    Osawa, R; Okitsu, T; Morozumi, H; Yamai, S

    1996-02-01

    A total of 132 strains of V. parahaemolyticus isolated from patients and from the suspected causal food items of past food poisoning cases occurring in Kanagawa Prefecture, Japan, were examined for the ability to hydrolyze urea, with specific reference to the presence of the thermostable direct hemolysin gene (tdh) and the gene for thermostable direct hemolysin-related hemolysin (trh). Ten strains belonging to five different O-antigen serotypes were positive for urea hydrolysis (UH+), and four of these strains did not carry tdh. A total of 106 strains carried tdh, but less than 6% of them were UH+, whereas all trh-carrying strains were UH+. The evidence suggests that urea hydrolysis is not a reliable marker for identifying tdh-carrying V. parahaemolyticus strains in Japan (the Pacific Northeast) but may be a marker for trh-carrying strains.

  15. [Incidence of Kanagawa phenomenon-positive and -negative Vibrio parahaemolyticus strains isolated from traveller's diarrhea and their relation to tdh and trh genes].

    Science.gov (United States)

    Suzuki, N; Ueda, Y; Furukawa, T; Takegaki, Y; Miyagi, K; Noda, K; Hirose, H; Hashimoto, S; Yano, S; Ishibashi, M; Honda, T

    1997-05-01

    A total of 1,319 strains of Vibrio parahaemolyticus isolated from traveller's diarrhea were analysed for Kanagawa phenomenon (KP) with the Wagatsuma blood agar test and the results were also compared with those of analyses of tdh and trh genes which encode thermostable direct hemolysin (tdh) and TDH-related hemolysin (trh). The majority of the strains (1,152 strains) counting 87.3% had positive KP, among which 1,049 and 103 strains were only tdh and both tdh and trh-positive ones, respectively. However, 167 strains counting 12.7%, which is quite high compared to the previous report, were found to have negative KP, among which 94 and 24 strains were only trh and both tdh and trh-positive ones, respectively.

  16. Changes in the frequency and clinical features of suicide attempts in the midwestern area of Kanagawa after the great East Japan earthquake.

    Science.gov (United States)

    Kato, Koji; Mikami, Katsunaka; Kimoto, Keitaro; Kimoto, Kousuke; Takahashi, Yuki; Sato, Reiko; Matsumoto, Hideo

    2014-03-01

    The aim of this study was to investigate the relationship between the clinical features of suicide attempts and the Great East Japan earthquake in Kanagawa. We enrolled 592 patients who attempted suicide and were hospitalized for inpatient treatment. Clinical features were compared between before the earthquake (A) and after the earthquake (B) groups. The number of suicide attempts increased from 286 to 306. The rate of increase in suicide attempts in men was the highest in the age group of 40-59 years. The frequency of joblessness, family psychiatric histories, precipitating event, and alcohol intake at suicide attempt was significantly higher in the B group than in the A group. The number of patients in serious condition in the B group was significantly higher than that in the A group. Other clinical features related to suicide in people who were indirectly affected by the earthquake disaster should be investigated to develop targeted prevention strategies. © 2014 American Academy of Forensic Sciences.

  17. Characterisation of a haemolysin related to Vp-TDH produced by a Kanagawa phenomenon-negative clinical isolate of Vibrio parahaemolyticus.

    Science.gov (United States)

    Nagayama, K; Yamamoto, K; Mitawani, T; Honda, T

    1995-02-01

    The production of a family of haemolysins--thermostable direct haemolysin (Vp-TDH), Vp-TDH-related haemolysin (Vp-TRH) and Vp-TDH/I--has been reported in clinical isolates of Vibrio parahaemolyticus. This paper describes a fourth type of haemolysin--Vp-TDH/II--produced by a Kanagawa phenomenon-negative clinical isolate of V. parahaemolyticus (O13:K, untypable). Vp-TDH/II was purified by ammonium sulphate precipitation and successive filtrations on DEAE-cellulose, hydroxyapatite, Sepharose 4B and Mono Q columns. Vp-TDH/II was biophysicochemically and immunologically similar to, but not identical to Vp-TDH, Vp-TRH and Vp-TDH/I. Vp-TDH/II stimulated vascular permeability in rabbit skin and was lethal to mice. Purified Vp-TDH/II and viable cells of the Vp-TDH/II-producing strain both induced fluid accumulation in ligated rabbit intestine. The plasmid-determined structural gene for Vp-TDH/II was cloned and the nucleotide sequence determined. The deduced amino acid sequence of Vp-TDH/II differed from those of Vp-TDH, Vp-TRH and Vp-TDH/I.

  18. Cytochrome p450 induction and gonadal status alteration in common carp (Cyprinus carpio) associated with the discharge of dioxin contaminated effluent to the Hikiji River, Kanagawa Prefecture, Japan.

    Science.gov (United States)

    Sakamoto, Kentaro Q; Nakai, Kiyotaka; Aoto, Takahiro; Yokoyama, Aiko; Ushikoshi, Ryoko; Hirose, Hitomi; Ishizuka, Mayumi; Kazusaka, Akio; Fujita, Shoichi

    2003-05-01

    Accumulations of polychlorinated dibenzo-p-dioxins, dibenzofurans and coplanar polychlorinated biphenyls were analyzed in common carp (Cyprinus carpio) collected in the Hikiji River, Kanagawa Prefecture, Japan in which dioxin contaminated effluent was released during the period starting from November 1992 to March 2000. Higher levels of 2,3,7,8-tetrachlorinated dibenzo-p-dioxin toxic equivalents were observed in carps collected downstream to the dioxin release site (contaminated site) than the reference site. Modulations of cytochrome p450 (CYP) enzyme in liver, serum estrogen concentration and gonadal somatic index (GSI) were also measured as biomarkers for the contaminants. Total CYP content in livers was markedly higher in male and female carps from the contaminated site relative to the reference site fish. The expression level of the cytochrome p450 1A and Ethoxyresorufin O-deethylase activity were significantly higher in female carps from the contaminated site than from the reference site. A lower level of plasma estrogen was observed in carps from the contaminated site. The GSI in female carps from the contaminated site was smaller than that recorded at the reference site. The present study indicates that dioxins released to the Hikiji River might induce the CYP enzyme and inhibit the reproductive functions in common carps dwelling downstream from the release site.

  19. Web-based recruiting for a survey on knowledge and awareness of cervical cancer prevention among young women living in Kanagawa prefecture, Japan.

    Science.gov (United States)

    Miyagi, Etsuko; Motoki, Yoko; Asai-Sato, Mikiko; Taguri, Masataka; Morita, Satoshi; Hirahara, Fumiki; Wark, John D; Garland, Suzanne M

    2014-09-01

    Cervical cancer (CC) incidence and mortality among young women have been increasing in Japan. To develop effective measures to combat this, we assessed the feasibility of using a social networking site (SNS) to recruit a representative sample of young women to conduct a knowledge and attitude study about CC prevention via an internet-based questionnaire. From July 2012 to March 2013, advertising banners targeting women aged 16 to 35 years in Kanagawa Prefecture were placed on Facebook in a similar manner as an Australian (AUS) study conducted in 16- to 25-year-olds in 2010 and on a homepage to advertise our CC advocacy activities. Eligible participants were emailed instructions for accessing our secure Web site where they completed an online survey including demographics, awareness, and knowledge of human papillomavirus (HPV) and CC. Data for the study population were compared with the general Japanese population and the AUS study. Among 394 women who expressed interest, 243 (62%) completed the survey, with 52% completing it via Facebook. Women aged 26 to 35 years, living in Yokohama City, with an education beyond high school, were overrepresented. Participants had high awareness and knowledge of HPV and CC, comparable with the AUS study participants. However, the self-reported HPV vaccination rate (22% among participants aged 16-25 years) and the recognition rate of the link between smoking and CC (31%) were significantly lower than in the AUS study (58% and 43%, respectively) (P < 0.05). Significant predictors of high knowledge scores about HPV included awareness of HPV vaccine (P < 0.001) and self-reported HPV vaccination (P < 0.05). The SNS and homepage are efficient methods to recruit young women into health surveys, which can effectively be performed online. A nationwide survey using SNSs would be an appropriate next step to better understand the current lack of uptake of the national HPV vaccine program by young women in Japan.

  20. 日本近代写实主义传统的突破--论野间宏《骰子的天空》中的“新写实主义”%A Breakthrough in the Tradition of Japanese Modern Realism--Research on the“New Realism”Expressed in the Novel Saikorono Sora Written by Noma Hiroshi

    Institute of Scientific and Technical Information of China (English)

    莫琼莎; 赵峻

    2013-01-01

    日本“战后派”作家野间宏借鉴以巴尔扎克为代表的近代欧洲的小说理论和小说实践,结合日本战后证券社会的现实创作出独特的长篇小说--《骰子的天空》,野间宏突破了日本近代以来既有的小说概念,在变革小说形式的同时,创造出了具有“新写实主义”风格的小说世界。本论文从“新写实主义”在野间宏“全体小说”创作中的作用、“新写实主义”与日本近代写实主义传统间的传承和突破、“新写实主义”与日本无产阶级文学的“现实主义”之间的区别等方面全面分析了具有野间宏特色的写实主义小说创作特点。%Noma Hiroshi, the famous Japanese post-war author, wrote the unique novel SaikoronoSora, or“Dice Sky”, using the modern European novel theory mainly created by Balzac. In SaikoronoSora, Noma Hiroshi made a breakthrough in traditional Japanese modern realism and built a new novel world of“New Modern Realism”. The paper tries to point out the characteristics of this“New Modern Realism”from three aspects:the effect of“New Modern Realism”in Noma Hiroshi’s“Total Novel”works;the relationship between“New Modern Realism”and Japanese traditional modern realism;and the difference between“New Modern Realism”and the realism expressed in Japanese Proletarian Literature.

  1. Two Questions in "Studies in the Ancient History of Japan" of Hiroshi Ikeuchi%关于《日本上古史研究--日鲜关系与日本书纪》中存在的两个问题

    Institute of Scientific and Technical Information of China (English)

    陈俊达

    2014-01-01

    As a famous historian and Oriental history scholar in modern Japan, Ikeuchi Hiroshi made great achievements in his life, especially in the fields of Manchu history and Korean history. He is the pioneer who studied Japanese history and Oriental history through new methods of historical research in Europe and America. His ideas of ' doubt ' and ' distinguishment ' towards historical materials in "Studies in the Ancient History of Japan" provided guides for historical research. However, there were some questions in the book as well, because of the times ' and personal limitations. For example, both "Nihon Shoki" and the national power of Japan in fourth century lacked enough textual research on annals.%日本近代著名的历史学家、东洋史学家池内宏在《日本上古史研究---日鲜关系与日本书纪》中体现出的对史料的质疑与辨伪的思想,对史学研究具有重要的指导作用。但由于时代及个人局限,书中同样存在一些问题。如对《日本书纪》中纪年考辨不足,对四世纪日本国力考辨不足等。

  2. Development of new type of nonlinear optical materials with a function of ultrafast optical modulation; Chokosoku hikari reiki hencho kino wo motsu atarashii hisenkei kogaku zairyo no kaihatsu

    Energy Technology Data Exchange (ETDEWEB)

    Sakaguchi, H. [Shizuoka University, Shizuoka (Japan). Research Institute of Electronics

    1995-12-15

    Ultrafast modulation of second harmonies from a Langmuir-Blodgett film consisting of a ruthenium complex was demonstrated for the first time. The mechanism of the modulator of SHG intensity on laser irradiation was ascribed to the change of molecular hyperpolarizability of the ruthenium complex on going from the ground state to the excited state. 9 refs., 12 figs.

  3. Anti-inflammatory effects of hyaluronan in arthritis therapy: Not just for viscosity

    Directory of Open Access Journals (Sweden)

    Kayo Masuko

    2009-04-01

    Full Text Available Kayo Masuko1, Minako Murata2, Kazuo Yudoh2, Tomohiro Kato1, Hiroshi Nakamura31Department of Biochemistry; 2Institute of Medical Science, St. Marianna University School of Medicine, Kawasaki-shi, Kanagawa, Japan; 3Department of Joint Disease and Rheumatism, Nippon Medical School, Bunkyo-ku, Tokyo, JapanAbstract: Hyaluronic acid (HA has been widely used for viscosupplementation of diseased or aged articular joints. However, recent investigations have revealed the active anti-inflammatory or chondroprotective effect of HA, suggesting its potential role in attenuation of joint damage. In particular, interactions between HA and other inflammatory mediators are attracting interest. This review summarizes several aspects of recent investigations of the anti-inflammatory effects of HA in arthritis.Keywords: hyaluronan, inflammation, chondroprotection

  4. An Interpretation of Noma Hiroshi's "Red Moon in Her Face"%文本解读:野间宏的《脸上的红月亮》

    Institute of Scientific and Technical Information of China (English)

    崔新京

    2001-01-01

    @@ 日本现代文学史的案头上,陈放着一个似已尘封的文学文本.它便是日本现代著名作家野间宏(1915-1991)的小说①.野间宏作为日本"战后派"的代表作家,一生创作了诸多脍炙人口的文学作品,取得了令人瞩目的艺术成就.他还曾于1962年5月和1982年12月,两次率日本文学代表团访问中国,不仅与茅盾、老舍、巴金、丁玲等中国作家结下了深厚友谊,也为中日文学交流做出了重要贡献.在21世纪的今天,重新解读,感受并体味这篇小说的深长意蕴和艺术魅力,或许会有特殊的历史意义和重要的审美价值.

  5. Thomas Demand e suas alegorias da intenção; "exclusão" em Candida Höfer, Hiroshi Sugimoto, e Thomas Struth

    Directory of Open Access Journals (Sweden)

    Michael Fried

    Full Text Available Resumo Em 2008, com a publicação de Why photography matters as art as never before, Michael Fried retoma as discussões iniciadas em “Arte e objetidade”, ensaio de 1967, em especial a ideia de "absorção" ou antiteatralidade da arte, suposta característica da arte modernista em contraposição à minimalista/literalista. Fried debate a questão da "presença", argumentando em prol da antiteatralidade, considerando a "absorção" como a principal qualidade nos trabalhos fotográficos de Thomas Struth, Thomas Demand, Candida Höfer entre outros, sobretudo no capítulo 9, aqui traduzido. A partir de uma minuciosa descrição e da análise formal das imagens, Fried encontra parâmetros para consolidar seu principal argumento: a capacidade de "absorção" da fotografias.

  6. Relationships between oxygen content, modulation period and superconducting property of Bi-based superconducting oxides. Bi kei sankabtsu chodendotai ni okeru sanso ganryo, hencho kozo oyobi chodendo tokusei no sokan

    Energy Technology Data Exchange (ETDEWEB)

    Deshimaru, Y.; Shimizu, Y.; Miura, N.; Yamazoe, N. (Kyushu Univ., Fukuoka (Japan). Graduate School of Engineering Sciences); Hiroi, Z.; Bando, Y. (Kyoto Univ., Kyoto (Japan). Inst. for Chemical Research)

    1992-09-10

    Two (2223 and 2212) of three superconducting phases in the Pb-doped Bi-Sr-Ca-Cu-O (BSCCO) oxide superconductor were examined for their changes of crystal structures and superconducting properties with changing oxygen content. Their oxygen sorption behavior examined by the temperature-programmed-desorption method showed that both samples desorb trace amounts of oxygen in a temperature range of 350-600 centigrade and the behavior examined by the temperature-programmed oxidation method showed that they absorb (absorb) reversibly oxygen desorbed above in a range of 100-350 centigrade. The critical temperature to bear diamagnetism (Tc) of the 2223 sample fell from 111 K to 96 K as oxygen was desorbed up to 600 centigrade. However, Tc recovers reversibly to the initial value when oxygen was re-absorbed. Contrary to the 2223, the 2212 sample showed the opposite Tc change. Both samples increased in their c-axes lengths and their modulation periods and the changes were reversible respectively. It was pointed out that the Tc behaviors of both sample systems were dependent on the concentration of holes on the CuO2 surfaces. 33 refs., 9 figs.

  7. Bilateral herpes simplex keratitis in a patient with chronic graft-versus-host disease

    Directory of Open Access Journals (Sweden)

    Takahiko Hayashi

    2008-06-01

    Full Text Available Takahiko Hayashi1, Misaki Ishioka2, Norihiko Ito1, Yoko Kato1, Hisashi Nakagawa3, Hiroshi Hatano4, Nobuhisa Mizuki11Department of Ophthalmology, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan; 2Ryogoku Eye Clinic, Tokyo, Japan; 3Tokushima Eye Clinic, Higashimurayama-shi, Tokyo, Japan; 4Lumine Hatano Eye Clinic, Fujisawa, Fujisawa-shi, Kanagawa, JapanPurpose: To describe a case of bilateral herpes simplex keratitis accompanying chronic graft-versus-host disease (GVHD.Design: Observational case report.Case report: An 11-year-old boy with myelocytic leukemia underwent allogeneic bone marrow transplantation. He developed symptoms of the skin, eyes, and mouth, and lip biopsy indicated chronic GVHD. Persistent keratitis with corneal filaments and neovascularization was noted in both eyes. Sodium hyaluronate, autoserum, and 0.1% fluorometholone eyedrops were instilled for approximately 2 years to treat this keratitis, and there were no other ocular changes. Bilateral herpes simplex keratitis developed with geographic ulcers after topical betamethasone therapy, but responded to acyclovir ointment.Conclusions: Herpes keratitis should be considered in the differential diagnosis of bilateral keratitis in patients with reduced immunocompetence. During the course of chronic GVHD, corneal herpes may occur, so ocular treatment with topical corticosteroids should be managed by an ophthalmologist to monitor sight-threatening conditions such as corneal herpes.Keywords: chronic graft-versus-host disease, bone marrow transplant, corneal herpes, bilateral herpes simplex keratitis, dry eyes

  8. Kanagawa-negative, tdh- and trh-positive Vibrio parahaemolyticus isolated from fresh oysters marketed in Fortaleza, Brazil.

    Science.gov (United States)

    Vieira, Regine H S F; Costa, Renata A; Menezes, Francisca G R; Silva, Giselle C; Theophilo, Grace N D; Rodrigues, Dália P; Maggioni, Rodrigo

    2011-08-01

    Between October 2008 and June 2009, 15 samples of 10 live oysters each (Crassostrea rhizophorae) measuring 8.31-10.71 cm were purchased from a restaurant on the seashore of Fortaleza, Brazil. The Vibrio count ranged from 75 (estimated) to 43,500 CFU/g. Fourteen species were identified among the 56 isolated Vibrio strains, with V. parahaemolyticus as the most prevalent. Two of the 17 V. parahaemolyticus strains were urease-positive and tdh- and trh-positive on multiplex PCR, but neither produced β-hemolysis halos in Wagatsuma agar. Thus, fresh oysters served in natura in Fortaleza, Brazil, were found to contain Vibrio strains known to cause gastroenteritis in humans.

  9. Ar-40/Ar-39 Ages for Maskelynites and K-Rich Melt from Olivine-Rich Lithology in (Kanagawa) Zagami

    Science.gov (United States)

    Park, J.; Herzog, G. F.; Nyquist, L. E.; Lindsay, F.; Turrin, B.; Swisher, C. C., III; Delaney, J. S.; Shih, C.-Y.; Niihara, T.; Misawa, K.

    2013-01-01

    We report Ar/Ar release patterns for small maskelynite grains and samples of a K-rich phase separated from the basaltic shergottite Zagami. The purpose of the work is to investigate the well-known discrepancy between published Ar/Ar ages of Zagami, >200 Ma, and its age of approx. 170 Ma as determined by other methods [1-6]. Niihara et al. [7] divide less abundant darker material present in Zagami into an olivine-rich lithology (ORL), from which most of our samples came, and a pyroxene-rich one (Dark Mottled-Lithology: DML) [8, 9]. ORL consists of vermicular fayalitic olivine, coarse-grained pyroxene, maskelynite, and a glassy phase exceptionally rich in K (up to 8.5 wt%), Al, and Si, but poor in Fe and Mg. The elemental composition suggests a late-stage melt, i.e., residual material that solidified late in a fractional crystallization sequence. Below we refer to it as "K-rich melt." The K-rich melt contains laths of captured olivine, Ca-rich pyroxene, plagioclase, and opaques. It seemed to offer an especially promising target for Ar-40/Ar-39 dating.

  10. Glucosamine-containing supplement improves locomotor functions in subjects with knee pain – a pilot study of gait analysis

    Directory of Open Access Journals (Sweden)

    Kanzaki N

    2016-06-01

    Full Text Available Noriyuki Kanzaki,1 Yuta Otsuka,1 Takayuki Izumo,1 Hiroshi Shibata,1 Hideyuki Nagao,2 Keita Ogawara,3 Hiroshi Yamada,3 Seiji Miyazaki,3 Yutaka Nakamura3 1Institute for Health Care Science, Suntory Wellness Ltd, Seika-cho, Soraku-gun, Kyoto, Japan; 2Research Institute of Sports Medical Science, Tokai University, Hiratsuka, Kanagawa, Japan; 3School of Physical Education, Tokai University, Hiratsuka, Kanagawa, Japan Background: Previously, we demonstrated that glucosamine-containing supplementation was effective for improving locomotor functions, especially walking speed. However, the biomechanical mechanism of efficacy has not been elucidated. This study aimed to address this challenge in subjects with knee pain, using a motion capture system. Methods: An open label study was conducted in 30 Japanese subjects with knee pain. The subjects were administered a daily supplement containing 1,200 mg of glucosamine hydrochloride, 60 mg of chondroitin sulfate, 45 mg of type II collagen peptides, 90 mg of quercetin glycosides, 10 mg of imidazole peptides, 1 mg of proteoglycan, and 5 µg of vitamin D (GCQID. The intervention continued for 16 weeks. Efficacy for locomotor functions involving the knee joint was evaluated mainly using the Japanese Knee Osteoarthritis Measure (JKOM and the 5-question Geriatric Locomotive Function Scale (GLFS-5. To examine the biomechanical mechanism of efficacy for locomotor functions, motions of subjects in a normal walking state were captured. Gait analysis was conducted and efficacy for gait parameters such as normal walking speed, stride length, cadence, and angle of soles was evaluated. Results: GCQID significantly improved total scores on the JKOM and GLFS-5. In gait analysis, normal walking speed, stride length, and angle of soles at the end of the stance phase were all significantly increased, but cadence did not change significantly during the intervention period. There were significant intercorrelations of changes in

  11. Rationale and design of ASSAF-K (A study of the safety and efficacy of anticoagulant therapy in the treatment of atrial fibrillation in Kanagawa

    Directory of Open Access Journals (Sweden)

    Yutaka Hatori, MD, PhD

    2017-04-01

    Conclusions: The results of the study are expected to serve as the basis for providing clinical practice guidance to healthcare institutions in Japan, with the ultimate goals of better characterizing the appropriate use of OACs and providing clinical decision support to physicians to facilitate the design of appropriate therapeutic strategies and the selection of anticoagulants for the management of AF.

  12. Topical Workshop on Heterostructure Microelectronics for Information Systems Applications (TWHM-ISA 󈨦) Held in Shonan Village Center, Hayama-machi, Kanagawa, Japan on August 30-September 2, 1998

    Science.gov (United States)

    2007-11-02

    of Surface Recombination in Heterojunction Bipolar Transistors by Magnetotransport T. Nozu, T. Sugiyama, S. Hongo , K. Tsuda and K. Morizuka (Toshiba...Bipolar Transistors by Magnetotransport Tetsuro Nozu, Toru Sugiyama, Sadato Hongo , Kunio Tsuda, and Kohei Morizuka Advanced Semiconductor Devices...Hikosaka, K. 66 Miyamoto, Y. Hirama, A. 74 Mizutani, T. Hongo , S. 10 Mochizuki, K. Horio, K. 12 Mohammadi, S. Hsu, S. S. H. 36 Moll, N. Hutchinson, C

  13. 野间宏笔下的战后日本人--小说《脸上的红月亮》及《崩溃感觉》主人公评析%People in Post-war Japan Described by Noma Hiroshi--Analysis of Protagonists in Novels The Red Moon on the Face and The Feeling of Collapse

    Institute of Scientific and Technical Information of China (English)

    莫琼莎

    2005-01-01

    该文通过分析日本战后派作家野间宏的两部小说即和中的主人公形象,揭示了上个世纪三四十年代日本发动的侵略战争给日本国民,尤其是给一部分有知识、有一定良知的日本国民造成的不可痊愈的心灵创伤.作家从对人性摧残的层面强烈控诉了战争的罪恶.

  14. Effects of 16-week high-intensity interval training using upper and lower body ergometers on aerobic fitness and morphological changes in healthy men: a preliminary study

    Directory of Open Access Journals (Sweden)

    Osawa Y

    2014-11-01

    Full Text Available Yusuke Osawa,1,2,* Koichiro Azuma,3,* Shogo Tabata,3 Fuminori Katsukawa,2 Hiroyuki Ishida,2 Yuko Oguma,2 Toshihide Kawai,4 Hiroshi Itoh,4 Shigeo Okuda,5 Hideo Matsumoto3 1Japan Society for the Promotion of Science, Graduate School of Arts and Sciences, University of Tokyo, Tokyo, Japan; 2Sports Medicine Research Center, Keio University, Kanagawa, Japan; 3Institute for Integrated Sports Medicine, School of Medicine, Keio University, Tokyo, Japan; 4Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan; 5Department of Radiology, School of Medicine, Keio University, Tokyo, Japan *Yusuke Osawa and Koichiro Azuma are co-first authors of this article Abstract: It is unclear whether combined leg and arm high-intensity interval training (HIIT improves fitness and morphological characteristics equal to those of leg-based HIIT programs. The aim of this study was to compare the effects of HIIT using leg-cycling (LC and arm-cranking (AC ergometers with an HIIT program using only LC. Effects on aerobic capacity and skeletal muscle were analyzed. Twelve healthy male subjects were assigned into two groups. One performed LC-HIIT (n=7 and the other LC- and AC-HIIT (n=5 twice weekly for 16 weeks. The training programs consisted of eight to 12 sets of >90% VO2 (the oxygen uptake that can be utilized in one minute peak for 60 seconds with a 60-second active rest period. VO2 peak, watt peak, and heart rate were measured during an LC incremental exercise test. The cross-sectional area (CSA of trunk and thigh muscles as well as bone-free lean body mass were measured using magnetic resonance imaging and dual-energy X-ray absorptiometry. The watt peak increased from baseline in both the LC (23%±38%; P<0.05 and the LC–AC groups (11%±9%; P<0.05. The CSA of the quadriceps femoris muscles also increased from baseline in both the LC (11%±4%; P<0.05 and the LC–AC groups (5%±5%; P<0.05. In contrast, increases were observed in the CSA of

  15. Consumption of water containing over 3.5 mg of dissolved hydrogen could improve vascular endothelial function

    Directory of Open Access Journals (Sweden)

    Sakai T

    2014-10-01

    Full Text Available Takaaki Sakai,1 Bunpei Sato,2 Koji Hara,3 Yuichi Hara,3 Yuji Naritomi,3 Samon Koyanagi,1 Hiroshi Hara,3 Tetsuhiko Nagao,4 Toru Ishibashi51Department of Cardiology, Haradoi Hospital, Fukuoka, Japan; 2MiZ Company Limited, Fujisawa, Kanagawa, Japan; 3Department of Internal Medicine, Haradoi Hospital, Fukuoka, Japan; 4Midorino Clinic, Aoba, Higashi-ku, Fukuoka, Japan; 5Department of Rheumatology and Orthopedic Surgery, Haradoi Hospital, Fukuoka, Japan Background: The redox imbalance between nitric oxide and superoxide generated in the endothelium is thought to play a pivotal role in the development of endothelial dysfunction. A third reactive oxygen species (ROS, H2O2, is known to have both beneficial and detrimental effects on the vasculature. Nonetheless, the influence of the hydroxyl radical, a byproduct of H2O2 decay, is unclear, and there is no direct evidence that the hydroxyl radical impairs endothelial function in conduit arteries. Molecular hydrogen (H2 neutralizes detrimental ROS, especially the hydroxyl radical. Objectives: To assess the influence of the hydroxyl radical on the endothelium and to confirm that a gaseous antioxidant, H2, can be a useful modulator of blood vessel function. Methods: The efficacy of water containing a high concentration of H2 was tested by measuring flow-mediated dilation (FMD of the brachial artery (BA. The subjects were randomly divided into two groups: the high-H2 group, who drank high-H2 water containing 7 ppm H2 (3.5 mg H2 in 500 mL water; and the placebo group. Endothelial function was evaluated by measuring the FMD of the BA. After measurement of diameter of the BA and FMD at baseline, volunteers drank the high-H2 water or placebo water immediately and with a 30-minute interval; FMD was compared to baseline. Results: FMD increased in the high-H2 group (eight males; eight females from 6.80%±1.96% to 7.64%±1.68% (mean ± standard deviation and decreased from 8.07%±2.41% to 6.87%±2.94% in the placebo

  16. Magnetic nanoparticles of Fe3O4 enhance docetaxel-induced prostate cancer cell death

    Directory of Open Access Journals (Sweden)

    Sato A

    2013-08-01

    Full Text Available Akiko Sato,1 Naoki Itcho,1 Hitoshi Ishiguro,2,3 Daiki Okamoto,1 Naohito Kobayashi,4 Kazuaki Kawai,5 Hiroshi Kasai,5 Daisuke Kurioka,1 Hiroji Uemura,2 Yoshinobu Kubota,2 Masatoshi Watanabe11Laboratory for Medical Engineering, Division of Materials Science and Chemical Engineering, Graduate School of Engineering, Yokohama National University, Yokohama, Japan; 2Department of Urology, Yokohama City University Graduate School of Medicine, Yokohama, Japan; 3Photocatalyst Group, Kanagawa Academy of Science and Technology, Kawasaki, Japan; 4Department of Molecular Pathology, Yokohama City University Graduate School of Medicine, Yokohama, Japan; 5Department of Environmental Oncology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Kitakyushu, JapanAbstract: Docetaxel (DTX is one of the most important anticancer drugs; however, the severity of its adverse effects detracts from its practical use in the clinic. Magnetic nanoparticles of Fe3O4 (MgNPs-Fe3O4 can enhance the delivery and efficacy of anticancer drugs. We investigated the effects of MgNPs-Fe3O4 or DTX alone, and in combination with prostate cancer cell growth in vitro, as well as with the mechanism underlying the cytotoxic effects. MgNPs-Fe3O4 caused dose-dependent increases in reactive oxygen species levels in DU145, PC-3, and LNCaP cells; 8-hydroxydeoxyguanosine levels were also elevated. MgNPs-Fe3O4 alone reduced the viability of LNCaP and PC-3 cells; however, MgNPs-Fe3O4 enhanced the cytotoxic effect of a low dose of DTX in all three cell lines. MgNPs-Fe3O4 also augmented the percentage of DU145 cells undergoing apoptosis following treatment with low dose DTX. Expression of nuclear transcription factor κB in DU145 was not affected by MgNPs-Fe3O4 or DTX alone; however, combined treatment suppressed nuclear transcription factor κB expression. These findings offer the possibility that MgNPs-Fe3O4–low dose DTX combination therapy may be

  17. 小鼠动物毒性试验、神奈川溶血试验以及tdh试验对副溶血性弧菌致病性检测有效性的研究%Validity comparison on pathogenic Vibrio parahaemolyticus identification methods of mice models, Kanagawa hemolytic test, and tdh gene test

    Institute of Scientific and Technical Information of China (English)

    陈明环; 刘俊平; 王庆忠; 王宏萍; 刘国刚; 张继伦

    2010-01-01

    目的 比较小鼠动物腹腔注射、灌胃、神奈川溶血实验以及荧光tdh基因PCR反应对副溶血性弧菌致病性检测的有效性.方法 采用四种方法,对分离自腹泻者、水产品及自然水体中的菌株测定阳性率,以精确卡方统计比较结果.结果 tdh反应可区分腹泻者来源菌株阳性率为90.0%,水产品来源阳性率为9.62%,自然水体来源阳性率为7.32%, P<0.001.结论 荧光tdh 基因PCR反应可有效应用于致病性菌株检测.

  18. Strauss, R.: Symphony in F minor, Op. 12... Tokyo Metropolitan Symphony Orchestra / David Nice

    Index Scriptorium Estoniae

    Nice, David

    1994-01-01

    Uuest heliplaadist "Strauss, R.: Symphony in F minor, Op. 12... Tokyo Metropolitan Symphony Orchestra / Hiroshi Wakasugi. Denon CD CO-75 860 (54 minutes); Symphony - comparative version: SNO, Järvi" (8/93)(CHAN) CHAN 9166

  19. Nobel Prize 2014: Akasaki, Amano & Nakamura

    Science.gov (United States)

    Heber, Joerg

    2014-11-01

    The 2014 Nobel Prize in Physics has been awarded to Isamu Akasaki, Hiroshi Amano and Shuji Nakamura "for the invention of efficient blue light-emitting diodes which has enabled bright and energy-saving white light sources."

  20. Edward Teller Medal: Laudations and Citations 2005-2015

    Science.gov (United States)

    Hora, Heinrich; Miley, George H.

    2016-10-01

    The following sections are included: * Max Tabak * Joseph D. Kilkenny * Kunioki Mima * Brian R. Thomas * Ricardo Betti * Edward I. Moses * Christine Garban-Labaune * Bruce A. Remington * James Hammer * Richard Petrasso * Jie Zhang * Hiroshi Azechi

  1. Strauss, R.: Symphony in F minor, Op. 12... Tokyo Metropolitan Symphony Orchestra / David Nice

    Index Scriptorium Estoniae

    Nice, David

    1994-01-01

    Uuest heliplaadist "Strauss, R.: Symphony in F minor, Op. 12... Tokyo Metropolitan Symphony Orchestra / Hiroshi Wakasugi. Denon CD CO-75 860 (54 minutes); Symphony - comparative version: SNO, Järvi" (8/93)(CHAN) CHAN 9166

  2. Maria-Kristiina Ulasele tunnustus Dhakast

    Index Scriptorium Estoniae

    2006-01-01

    12. Aasia kunstibiennaalil Bangladeshis märgiti ära töö "Ükssarv meeliskleb Musta Madonna saladuste üle". Peapreemia jaapani kunstnik Hiroshi Fujile. Eestist osales ka Silvi Liiva ja Peeter Allik

  3. JPRS Report, Science & Technology, Japan, 28th Ceramics Science Discussion

    Science.gov (United States)

    2007-11-02

    Hiroshi Asakura, Hiroshi Yamamura] .............................. 59 Microstructure, Dielectric Properties of Tungsten Bronze -Type Ceramics [Yoji Ueda...of Strain 60 Microstructure, Dielectric Properties of Tungsten Bronze -Type Ceramics 906C7512 Tokyo SERAMIKKUSU KISO KAGAKU TORONKAI in Japanese 24 Jan...with different microstructures were produced for an oxide of the tungsten bronze type, Ba 0 . 5 Sr 0 . 5 Nb 20 6 , by varying the particle size and

  4. Development of Social Recommendation GIS for Tourist Spots

    National Research Council Canada - National Science Library

    Tsukasa IKEDA; Kayoko YAMAMOTO

    2014-01-01

    ...) Social media GIS, an information system which integrates Web-GIS, SNS and recommendation system into a single system, was conducted in the central part of Yokohama City in Kanagawa Prefecture, Japan...

  5. Problems of Education in Information Society

    OpenAIRE

    MINOH, Michihiko; 美濃, 導彦

    2011-01-01

    "Perspective on education in today’s highly advanced Information Society focusing upon principle and idea of education";SOKEN-OER 2nd Open Workshop February 24, 2011;The Graduate University for Advanced Studies (SOKENDAI)Rm.104;Hayama, Kanagawa

  6. FGFR1タンパク発現の低いFGFR1遺伝子増幅肺癌では他の活性型チロシンキナーゼ受容体がFGFR阻害剤の効果を軽減する

    OpenAIRE

    小谷, 浩

    2016-01-01

    博士論文要旨Abstract 以下に掲載:Oncogene Epub ahead of print Nature Publishing Group. 共著者:Hiroshi Kotani, Hiromichi Ebi, Hidenori Kitai, Shigeki Nanjo, Kenji Kita, Tiffany G. Huynh, Akishi Ooi, Anthony C. Faber, Mari Mino-Kenudson, Seiji Yano

  7. "Ars Electronica 2009" / Raivo Kelomees

    Index Scriptorium Estoniae

    Kelomees, Raivo, 1960-

    2009-01-01

    30. "Ars Electronica" festival "Human Nature" ("Inimese loomus") Linzis. Osaka ülikooli professori Hiroshi Ishiguro mehaanilis-digitaalsest nukust. Hübriidkunsti kategoorias peapreemia saanud Eduardo Kaci inimtaimest. Konverentsidest. Näitusest "See this Sound", mis oli pühendatud helile kujutavas kunstis

  8. Hotel Nikko Tianjin General Manager Interview

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Before the grand opening of Hotel Nikko Tianjin on April 11,Beijing Review conducted an interview with Mr.Hiroshi O’ishi,General Manager of the new hotel,in order to share the operational and management expertise of Nikko Hotels International with our readers.

  9. An empirical method to estimate bulk particulate refractive index for ocean satellite applications

    Digital Repository Service at National Institute of Oceanography (India)

    Suresh, T.; Desa, E.; Mascarenhas, A.A.M.Q.; Matondkar, S.G.P.; Naik, P.; Nayak, S.R.

    of the Marine Environment, edited by Robert J. Frouin, Vijay K. Agarwal, Hiroshi Kawamura, Shailesh Nayak, Delu Pan, Proc. of SPIE Vol. 6406, 64060B, (2006) 0277-786X/06/$15 ? doi: 10.1117/12.694212 Proc. of SPIE Vol. 6406 64060B-1 Proc. of SPIE Vol. 6406...

  10. Secchi depth analysis using bio-optical parameters measured in the Arabian Sea

    Digital Repository Service at National Institute of Oceanography (India)

    Suresh, T.; Naik, P.; Bandishte, M.; Desa, E.; Mascarenhas, A.A.M.Q.; Matondkar, S.G.P.

    of the Marine Environment, edited by Robert J. Frouin, Vijay K. Agarwal, Hiroshi Kawamura, Shailesh Nayak, Delu Pan, Proc. of SPIE Vol. 6406, 64061Q, (2006) 0277-786X/06/$15 ? doi: 10.1117/12.696251 Proc. of SPIE Vol. 6406 64061Q-1 a ) Summer 20 z C). C)-J 16...

  11. Efficacy of an aspiration device with distal protection for the treatment in acute myocardial infarction

    Institute of Scientific and Technical Information of China (English)

    Naoto Inoue

    2003-01-01

    @@ Hiroshi Fujita Kenji Suzuki Akiko Matsuo Reo Nakamura Tetsuya Tanaka Keiji Inoue Hisayuki Hyogo Takaomi Tokura Objective Percutaneous coronary interventions in the setting of acute myocardial infarction(AMI)have been associated with increased risk of distal embolization and no-reflow phenomenon. To evaluate the efficacy and feasibility of a distal protection using the PercuSurge Guardwire Plus( PSG) in AMI.

  12. "Ars Electronica 2009" / Raivo Kelomees

    Index Scriptorium Estoniae

    Kelomees, Raivo, 1960-

    2009-01-01

    30. "Ars Electronica" festival "Human Nature" ("Inimese loomus") Linzis. Osaka ülikooli professori Hiroshi Ishiguro mehaanilis-digitaalsest nukust. Hübriidkunsti kategoorias peapreemia saanud Eduardo Kaci inimtaimest. Konverentsidest. Näitusest "See this Sound", mis oli pühendatud helile kujutavas kunstis

  13. Models of alcoholic liver disease in rodents: a critical evaluation

    DEFF Research Database (Denmark)

    de la M. Hall, P.; Lieber, C.S.; De Carli, L.M.;

    2001-01-01

    This article represents the proceedings of a workshop at the 2000 ISBRA Meeting in Yokohama, Japan. The chairs were J. Christian Bode and Hiroshi Fukui. The presentations were (1) Essentials and the course of the pathological spectrum of alcoholic liver disease in humans, by P. de la M. Hall; (2)...

  14. Keemia- ja füüsikapreemiate märksõna on valgus / Arko Olesk

    Index Scriptorium Estoniae

    Olesk, Arko, 1981-

    2014-01-01

    Nobeli keemiapreemia pälvisid sakslane Stefan Hell ning ameeriklased Eric Betzig ja William Moerner, kes leidsid viisi, kuidas uurida valgusmikroskoobiga eluslooduse pisimaid komponente. Füüsikapreemia pälvisid Jaapani teadlased Isamu Akasaki, Hiroshi Amano ja Shuji Nakamura sinise valgusdioodi leiutamise eest

  15. New Data about the indigenous languages of the North / Ago Künnap

    Index Scriptorium Estoniae

    Künnap, Ago, 1941-

    1997-01-01

    Arvustus: Northern minority languages : problems of survival : papers presented at the 18th Taniguchi International Symposium, [held in Osaka, 7-14 November 1994] / edited by Hiroshi Shoji and Juha Janhunen. Osaka : National Museum of Ethnology, Division of Ethnology, 1997. (Senri ethnological studies ; 44). Sisaldab tabelit põhjarahvaste arvu ja keelte kõnelejate arvu kohta

  16. Keemia- ja füüsikapreemiate märksõna on valgus / Arko Olesk

    Index Scriptorium Estoniae

    Olesk, Arko, 1981-

    2014-01-01

    Nobeli keemiapreemia pälvisid sakslane Stefan Hell ning ameeriklased Eric Betzig ja William Moerner, kes leidsid viisi, kuidas uurida valgusmikroskoobiga eluslooduse pisimaid komponente. Füüsikapreemia pälvisid Jaapani teadlased Isamu Akasaki, Hiroshi Amano ja Shuji Nakamura sinise valgusdioodi leiutamise eest

  17. On JALT 95: Curriculum and Evaluation. Proceedings of the JALT International Conference on Language Teaching/Learning (22nd, Nagoya, Japan, November 1995). Section Two: Curriculum Design.

    Science.gov (United States)

    Harrison, Ian; And Others

    Texts of conference papers and summaries of colloquia on second language curriculum design are presented, including: "Competency Assessment in Curriculum Renewal" (summary of session with Ian Harrison, Francis Johnson, Christopher Candlin, Anthony Green, David Nunan, Charles Smith); "The Evolving of a Curriculum" (Hiroshi Abe,…

  18. "Material interactions": from atoms & bits to entangled practices

    DEFF Research Database (Denmark)

    Vallgårda, Anna

    and intellectually stimulating panel moderated by Prof. Mikael Wiberg consisting of a number of scholars with a well-developed view on digital materialities to fuel a discussion on material interactions - from atoms & bits to entangled practices. These scholars include: Prof. Hiroshi Ishii, Prof. Paul Dourish...

  19. New Data about the indigenous languages of the North / Ago Künnap

    Index Scriptorium Estoniae

    Künnap, Ago, 1941-

    1997-01-01

    Arvustus: Northern minority languages : problems of survival : papers presented at the 18th Taniguchi International Symposium, [held in Osaka, 7-14 November 1994] / edited by Hiroshi Shoji and Juha Janhunen. Osaka : National Museum of Ethnology, Division of Ethnology, 1997. (Senri ethnological studies ; 44). Sisaldab tabelit põhjarahvaste arvu ja keelte kõnelejate arvu kohta

  20. Isolation and characterization of Leptospira spp. from raccoons in Japan.

    Science.gov (United States)

    Koizumi, Nobuo; Uchida, Masaki; Makino, Takashi; Taguri, Toshitsugu; Kuroki, Toshiro; Muto, Maki; Kato, Yukio; Watanabe, Haruo

    2009-04-01

    We investigated whether raccoons (Procyon lotor) carried leptospires in their kidneys in Japan. Leptospira was isolated from 2 of 71 raccoons captured in Kanagawa Prefecture and 1 of 53 raccoons at a zoological park in Nagasaki Prefecture. Anti-Leptospira antibodies were detected in 16 of 124 raccoons (12.9%) in Kanagawa and 33 of 53 raccoons (62.3%) in Nagasaki, respectively. The partial nucleotide sequences of their flaB genes suggested that the isolates belonged to L. interrogans. The serovars of the isolates were identified as Copenhageni/Icterohaemorrhagiae (1 strain in Kanagawa) and Hebdomadis (1 strain both in Kanagawa and Nagasaki) by reactivity with the reference antisera and restriction fragment length polymorphism (RFLP) analysis based on pulsed-field gel electrophoresis and cross-agglutination-absorption test, respectively. RFLP analysis on the serovars Hebdomadis strains revealed genetic diversity among serovar Hebdomadis. Although it is unclear if the raccoons carried leptospires in their kidneys at the time imported, there is no doubt that imported animals are a new reservoir animal of leptospires in Japan.

  1. Proceedings for the Alaska Meeting on Fundamental Optical Processes in Semiconductors (AMFOPS 󈧅) Held in Girdwood, Alaska on August 5-10, 2001

    Science.gov (United States)

    2007-11-02

    1 Sakato, Takatsu-ku, Kanagawa 213-0012, Japan bDepartmnent of Applied Physics, Graduate School of Engineering, University of Tokyo, 7-3-1 Hongo ... Hongo , Bunkyo-ku, Tokyo 113-8656, Japan Search for syst,:ins with long lived quantum coherence is driven by the growing interest to the quantum

  2. An urban flood in the kashio river basin

    OpenAIRE

    Matsuda, Iware

    1987-01-01

    An urban flood is one of knotty problems derived from land development. Taking the Kashio River basin of Kanagawa Prefecture as an example, the relationships between urbanization and flood hazards were historically discussed. It was explained that a flood prevention work in one area affects other areas. The historical change in conditions for flood hazards can be divided into six stages.

  3. Effect of Heat (Arrhenius Effect) on Crude Hemolysin of Vibrio parahaemolyticus

    Science.gov (United States)

    Miwatani, Toshio; Takeda, Yoshifumi; Sakurai, Jun; Yoshihara, Akiko; Taga, Sekiko

    1972-01-01

    Crude hemolysins prepared from various strains of Vibrio parahaemolyticus, which give positive Kanagawa phenomenon, were partly inactivated by heating at 60 C, but not inactivated significantly by heating at 80 to 90 C. The similar phenomenon has been reported as the Arrhenius effect in staphylococcal alpha toxin. Images PMID:4638496

  4. 照亮21世纪的新型光源--2014年诺贝尔物理学奖介绍%The new light source shining 21 century:A brief introduction to the Nobel Prize in Physics 2014

    Institute of Scientific and Technical Information of China (English)

    潘笃武

    2014-01-01

    The Nobel Prize in Physics 2014 rewarded to Isamu Akasaki, Hiroshi Amano and Shuji Nakamura as they have invented the blue light-emitting diode (LED). It is a new energy-efficient and environment-friendly light source. The Laureates’research works and achievements are introduced briefly in this article . The physical principle and structure of the blue light-emitting diode are described sketchily.%2014年的诺贝尔物理学奖颁给发明蓝色发光二极管的赤崎勇(Isamu Akasaki)、天野浩(Hiroshi Amano)和中村修二(Shuji Nakamura)。简单介绍了获奖者的研究工作及成就,并简略描述了蓝色发光二极管的物理原理和结构。

  5. Reversible brain atrophy and cognitive impairment in an adolescent Japanese patient with primary adrenal Cushing’s syndrome

    OpenAIRE

    Ohara N; Suzuki H; Suzuki A.; Kaneko M; Ishizawa M; Furukawa K; Abe T; Matsubayashi Y; Yamada T.; Hanyu O; Shimohata T; Sone H

    2014-01-01

    Nobumasa Ohara,1 Hiroshi Suzuki,1 Akiko Suzuki,1 Masanori Kaneko,1 Masahiro Ishizawa,1 Kazuo Furukawa,1 Takahiro Abe,1 Yasuhiro Matsubayashi,1 Takaho Yamada,1 Osamu Hanyu,1 Takayoshi Shimohata,2 Hirohito Sone1 1Department of Hematology, Endocrinology and Metabolism, Faculty of Medicine, Niigata University, Niigata, Japan; 2Department of Neurology, Brain Research Institute, Niigata University, Niigata, Japan Abstract: Endogenous Cushing’s syndrome is an endocrine disease resulting ...

  6. Konsep Pre-emptive War sebagai Anticipatory Self-defense ditinjau dari Hukum Internasional

    OpenAIRE

    Rombot, Iona Hiroshi Yuki

    2013-01-01

    Iona Hiroshi Yuki Rombot (B11109421), Concept of Pre-emptive War as Anticipatory Self-Defense asessed from International Law. Supervised by Abdul Maasba Magassing and Albert Lokollo. This research intended to understand on how the concept of pre-emptive war as anticipatory self-defense within scope of international law. This research conduct based on ???library research??? method or through bibliography study, author collected both hardcopy and softcopy literatures and analyzed internatio...

  7. Oseltamivir reduces hippocampal abnormal EEG activities after a virus infection (influenza) in isoflurane-anesthetized rats

    OpenAIRE

    Inoue,, S.; Kido, Hiroshi

    2012-01-01

    Youssouf Cissé,1 Isao Inoue,2 Hiroshi Kido11Division of Enzyme Chemistry, 2Division of Molecular Neurobiology, Institute for Enzyme Research, University of Tokushima, Tokushima, JapanBackground: Oseltamivir phosphate (OP, Tamiflu®) is a widely used drug in the treatment of influenza with fever. However, case reports have associated OP intake with sudden abnormal behaviors. In rats infected by the influenza A virus (IAV), the electroencephalogram (EEG) displayed abnormal hig...

  8. JPRS Report, Science & Technology, Japan, 1989 S&T Agency Annual 33

    Science.gov (United States)

    2007-11-02

    34 Isamu Yamashita " Jiro Kondo " Hiroshi Inose " Kunio Kagayama «• Machiro Kawada •• Masakazu Sawa " Eiji Suzuki *’ Saburo Nagakura " Hiromichi...Nagata 10 June 1988 T Toshihiro Ishii 10 June 1988 A Accounting Division Manager Akira Takeda 10 June 1988 T Hiroto Sekida 10 June 1988 A Science...Division Manager Toshihiro Ishii 10 June 1988 M (General Affairs Division Man- ager) Mitsuhiro Nakamura 10 June 1988 A Planning Division Manager

  9. 日本における初期のカフカの影響 : 第二次世界大戦前後

    OpenAIRE

    有村, 隆広

    2014-01-01

    The first Japanese researcher of Kafka's literature was Hiroshi Okamura. In 1932, he wrote the essay Franz Kafka - the class system of loneliness, in which he argued that the solitude and despair of helpless people are expressed in The Metamorphosis. In 1940, Koichi Motono translated Kafka's novel The Trial from German into Japanese. He felt that Kafka described the anxiety and the loneliness of human beings in this novel. Atsushi Nakajima is the first Japanese writer who was influenced by Ka...

  10. Physical Mechanism of Wave-Particle Resonances in a Curved Magnetic Field.

    Science.gov (United States)

    1981-11-27

    Kusse Columbia University H. Fleischmann New York, New York 10027 C. Wharton Attn: R. Taussig P. Morse R. A. Cross R. Lovelace 17 Harvard University...Maryland 021-73 McLean, Virginia 22102 Gendrin, Roger Schulz, Michael CNET Aerospace Corp. 3 Ave. do la Republique A6/2451, P. 0. Box 92957 Issy-les...G21GO Iowa City, Iowa 52242 Meudon, FRANCE Temerin, Michael Space Science Lab. Kikuchi, Hiroshi University of California College of Sci. & Tech

  11. Erster Deutscher IPv6 Gipfel

    OpenAIRE

    Meinel, Christoph; Sack, Harald; Bross, Justus

    2009-01-01

    Inhalt: KOMMUNIQUÉ GRUßWORT PROGRAMM HINTERGRÜNDE UND FAKTEN REFERENTEN: BIOGRAFIE & VOTRAGSZUSAMMENFASSUNG 1.) DER ERSTE DEUTSCHE IPV6 GIPFEL AM HASSO PLATTNER INSTITUT IN POTSDAM - PROF. DR. CHRISTOPH MEINEL - VIVIANE REDING 2.) IPV6, ITS TIME HAS COME - VINTON CERF 3.) DIE BEDEUTUNG VON IPV6 FÜR DIE ÖFFENTLICHE VERWALTUNG IN DEUTSCHLAND - MARTIN SCHALLBRUCH 4.) TOWARDS THE FUTURE OF THE INTERNET - PROF. DR. LUTZ HEUSER 5.) IPV6 STRATEGY & DEPLOYMENT STATUS IN JAPAN - HIROSHI MIYATA 6.) IPV...

  12. 玻璃用涂料

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    玻璃防尘用的带负静电荷的涂装工艺及聚硅氧烷组合物:US2005—48293[美国专利申请公开]/美国:(Rood,Leonard D.),室温固化玻璃涂料的应用:JP2005-40725[日本专利公开]/日本:Sanhorony K.K.(Hosaka,Hiroshi)。

  13. Epoprostenol sodium for treatment of pulmonary arterial hypertension

    OpenAIRE

    Saito Y.; Nakamura K; Akagi S; Sarashina T; Ejiri K; Miura A; Ogawa A.; Matsubara H; Ito H

    2015-01-01

    Yukihiro Saito,1 Kazufumi Nakamura,1 Satoshi Akagi,1 Toshihiro Sarashina,1 Kentaro Ejiri,1 Aya Miura,1 Aiko Ogawa,2 Hiromi Matsubara,2 Hiroshi Ito1 1Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan; 2Division of Cardiology, National Hospital Organization Okayama Medical Center, Okayama, Japan Abstract: The release of endogenous prostacyclin (PGI2) is depressed in patients with pulmonary arterial hyper...

  14. Molecular Basis of Ion Channels and Receptors Involved in Nerve Excitation, Synaptic Transmission and Muscle Contraction

    Science.gov (United States)

    1993-12-20

    BARNARD, MARGARET SUTHERLAND, SHAHID ZAMAN, XMIT5UtIIKO ,MATSUMOTO. NAUSHABA NAVEEJM, TIMi GREEN~, MARK G. DARLITON, and ALAN N . BATESON ...Paralysis of a Japanese Family. By Kiciii ARAHAI A, JIANZ1iOt.: WANG, W. GREGORY FEFiRo. HIROSHI~ HAYAKAWA, Koicii HONDA. HIDEo SLGI-iA, and ERIC P. HOFI...8217 MARK G. DARLISONJ AND ALAN N. BATESON ’ ’Molecular Neurobiology Unit Division of Basic Medical Sciences Royal Free Hospital Scbool of Medicine London NW3

  15. SABIC Innovative Plastics: Be the World Best Plastic Resin Manufacturer

    Institute of Scientific and Technical Information of China (English)

    Jenny Du

    2007-01-01

    @@ "SABIC Innovative Plastics is a global supplier of plastic resins, manufacturing and compounding polycarbonate, ABS, SAN, ASA, PPE, PC/ABS, PBT and PEI resins, as well as the LNP* line of high performance specialty compounds," said Hiroshi Yoshida, the Global Market Director for Electronics of SABIC Innovative Plastics based in Tokyo at the press conference held by SABIC Innovative Plastics, November 8th 2007, Shanghai.

  16. Antihypertensive effects of astaxanthin

    OpenAIRE

    Yanai, Hidekatsu

    2008-01-01

    Hidekatsu Yanai1,2, Kumie Ito1,2, Hiroshi Yoshida2,3, Norio Tada1,21Department of Internal Medicine; 2Institute of Clinical Medicine and Research; 3Department of Laboratory Medicine, The Jikei University School of Medicine, Chiba, JapanAbstract: Astaxanthin is a biological antioxidant naturally found in a wide variety of aquatic living organisms, and has shown various pharmacological activities, such as anti-inflammatory and antidiabetic activities. A recent study reported that the administra...

  17. A new species of Dalbergia (Leguminosae from Malay Peninsula

    Directory of Open Access Journals (Sweden)

    Bambang - Sunarno

    2003-12-01

    Full Text Available SUNARNO, BAMBANG & OHASHI, HIROSHI. 2002. A new species of Dalbergia (Leguminosae from Malay Peninsula. Reinwardtia 12(1: 117–119. ⎯ A new species, Dalbergia johoriensis from the Malay Peninsula is described. It is close to D. rostrata and D. havilandii but readily distinguished by the grooved midrib beneath, flowers with narrower standard and wings and style hairy in the lower part.

  18. 手外科杂志(美国卷)近期部分文章摘要译文

    Institute of Scientific and Technical Information of China (English)

    马世伟

    2003-01-01

    @@ 1.由屈肌腱滑膜脂肪瘤引发板机腕及腕管综合征1例报告 本文译自(美国卷)2002年第27卷第6期,作者:Hironori Sonoda,Mitsuhiro Takasita,Hirofu-mi Taira, Tsutomu Higashi and Hiroshi Tsumura.文题:Carpal tunnel syndrome and trigger wrist caused bya lipoma arising from flexor tenosynovium a casereport

  19. Hiroshima University Research and Technology Guide 2012 Version : Life Science

    OpenAIRE

    Center for Collaborative Research & Community Cooperation,

    2012-01-01

    I Life ScienceDevelopment of Treatment Strategy for Hepatocellular Carcinoma to Improve the Long Term Prognosis / Hiroshi AIKATA...2Development of Revolutional Apatite-implant Complex with Simultaneous Bone Augmentation and Osseointegration / Yasumasa AKAGAWA...3How Do Patients with Alzheimer’s Disease Experience Memory Impairments? / Sawako ARAI...4Development of New Therapies for Chronic Viral Hepatitis Using Human Hepatocyte Chimeric Mice / Kazuaki CHAYAMA...5Identification of High Risk Pa...

  20. Hiroshima University Research and Technology Guide 2012 Version : Life Science

    OpenAIRE

    Center for Collaborative Research & Community Cooperation,

    2012-01-01

    I Life ScienceDevelopment of Treatment Strategy for Hepatocellular Carcinoma to Improve the Long Term Prognosis / Hiroshi AIKATA...2Development of Revolutional Apatite-implant Complex with Simultaneous Bone Augmentation and Osseointegration / Yasumasa AKAGAWA...3How Do Patients with Alzheimer’s Disease Experience Memory Impairments? / Sawako ARAI...4Development of New Therapies for Chronic Viral Hepatitis Using Human Hepatocyte Chimeric Mice / Kazuaki CHAYAMA...5Identification of High Risk Pa...

  1. Understanding and Harnessing the Power of Ideas, Persuasion, and Trust

    Science.gov (United States)

    2013-09-17

    Information Sharing Behavior in Social Network Sites Norhayati Zakaria* nzakaria@ksu.edu.sa Hiroshi Yama Saudi Elect U, SA Osaka City, JP...gateway for technology transfer. Technology Transfer in a Global Economy : Proceedings of the Technology Transfer Society, Dayton, OH, 277-282. FINAL...Design: Japan, April 1985. University of Tokyo, Komaba, Tokyo University of Kyoto, Kyoto University of Osaka , Toyonaka, Osaka Aichi Institute of

  2. Serological survey of five zoonoses, scrub typhus, Japanese spotted fever, tularemia, Lyme disease, and Q fever, in feral raccoons (Procyon lotor) in Japan.

    Science.gov (United States)

    Inoue, Kai; Kabeya, Hidenori; Fujita, Hiromi; Makino, Takashi; Asano, Makoto; Inoue, Satoshi; Inokuma, Hisashi; Nogami, Sadao; Maruyama, Soichi

    2011-01-01

    We investigated the seroprevalence of five tick- or mite-borne zoonoses, scrub typhus (Orientia tsutsugamushi), Japanese spotted fever (Rickettsia japonica), tularemia (Francisella tularensis), Lyme disease (Borrelia afzelii and Borrelia garinii), and Q fever (Coxiella burnetii), in feral raccoons (Procyon lotor) captured in Hokkaido and Kanagawa Prefectures in Japan. Of the 559 raccoons captured in Hokkaido, 8 (1.4%), 3 (0.5%), 1 (0.2%), and 1 (0.2%) carried antibodies against O. tsutsugamushi (Gilliam type), F. tularensis, B. afzelii, and B. garinii, respectively. Of the 193 animals investigated in Kanagawa, 31 (16.1%) and 14 (7.3%) carried antibodies against O. tsutsugamushi and R. japonica, respectively, and the major serotype (27/31) of O. tsutsugamushi was Kuroki. No antibodies against C. burnetii were detected in either area examined. Therefore, feral raccoons could be an indicator of the prevalence of these four tick- or mite-borne zoonoses in the peridomestic environment in Japan.

  3. Additional Sr Isotopic Heterogeneity in Zagami Olivine-Rich Lithology

    Science.gov (United States)

    Misawa, K.; Niihara, T.; Shih, C.-Y; Reese, Y. D.; Nyquist, L. E.; Yoneda, S.; Yamashita, H.

    2012-01-01

    Prior isotopic analyses of Zagami have established differing initial Sr-87/Sr-86 (ISr) ratios of among Zagami lithologies, fine-grained (FG), coarse-grained (CG), and dark mottled lithologies (DML)]. The Zagami sample (KPM-NLH000057) newly allocated from the Kanagawa Prefectural Museum of Natural History contained DML and the Ol-rich lithology which included more ferroan olivines (Ol-rich: Fa(sub 97- 99) vs late-stage melt pockets: Fa(sub 90-97)]). We have combined mineralogy-petrology and Rb-Sr isotopic studies on the Kanagawa Zagami sample, which will provide additional clues to the genesis of enriched shergottites and to the evolution of Martian crust and mantle

  4. Manned Gaming and Simulation Relating to Terrorism and Weapons of Mass Destruction: A Review of the Literature

    Science.gov (United States)

    2004-04-17

    Bank Station London 10/082003 Unspecified Field Chemical China Northern Region, Inner Mongolia Unspecified Shanghai Cooperation Organization...MI) BCW: dm at soccer stadium (table-top) Kanagawa PP; JAWOC BCNR TRO Incident Hokkaido PG, PP, Sapporo CG, CFD, MC; SDF; MI BCW: dm at soccer...stadium (table-top) Fukuoka PP, CFD; SDF CW: dm at hotels JAWOC; Niigata PG, PP, CDF BCW: dm at soccer stadium JAWOC; Hokkaido PP; Sapporo CFD; MI CW

  5. ONR (Office of Naval Research) Far East Scientific Information Bulletin. Volume 14, Number 3, July-September 1989

    Science.gov (United States)

    1989-09-01

    Masahiro Yoshimura Tokyo Institute of Technology Preparation of Mullite Kenya Hamano Kanagawa University Ceramics from Kaolin Hiroaki Nakajima and... Kaolin Hiromichi Ichinose Sachiko Furuta Shuji Yoshida Makoto Egashita Nagasaki University Microstructure and Mechanical Teruhiko Kinoshita Tokyo...cutting angle error and they tures, are thought to be less sensitive to can be grown from a congruent melt, but sulphur . they grow only at 2.5 mm/h

  6. Systemic lupus erythematosus: strategies to improve pregnancy outcomes

    OpenAIRE

    Yamamoto Y; Aoki S

    2016-01-01

    Yuriko Yamamoto, Shigeru Aoki Perinatal Center for Maternity and Neonate, Yokohama City University Medical Center, Yokohama, Kanagawa Prefecture, Japan Abstract: Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease with a high prevalence in females of childbearing age. Thus, reproduction in SLE patients is a major concern for clinicians. In the past, SLE patients were advised to defer pregnancy because of poor pregnancy outcomes and fear of SLE flares during pregn...

  7. Demonstration and characterization of simultaneous production of a thermostable direct hemolysin (TDH/I) and a TDH-related hemolysin (TRHx) by a clinically isolated Vibrio parahaemolyticus strain, TH3766.

    OpenAIRE

    Xu, M.; Iida, T; Yamamoto, K.; Takarada, Y; Miwatani, T; Honda, T.

    1994-01-01

    Simultaneous production of a thermostable direct hemolysin (TDH)-like toxin (TDHx) and a TDH-related hemolysin (TRH)-like toxin (TRHx) by a clinical isolate (strain TH3766) of Kanagawa phenomenon-positive Vibrio parahaemolyticus was demonstrated and characterized. The two hemolysins were differentially purified by column chromatography on hydroxyapatite and immunoaffinity columns. The molecular weight of the two hemolysins were estimated to be 23,000 by sodium dodecyl sulfate-polyacrylamide g...

  8. Chum salmon egg extracts induce upregulation of collagen type I and exert antioxidative effects on human dermal fibroblast cultures

    OpenAIRE

    Yoshino A; Polouliakh N; Meguro A; Takeuchi M; Kawagoe T; Mizuki N

    2016-01-01

    Atsushi Yoshino,1 Natalia Polouliakh,1–3 Akira Meguro,1 Masaki Takeuchi,1,4 Tatsukata Kawagoe,1 Nobuhisa Mizuki1 1Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, 2Sony Computer Science Laboratories Inc., Fundamental Research Laboratories, 3Systems Biology Institute, Tokyo, Japan; 4Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA Abstract...

  9. Cyber-Based Turbulent Combustion Simulation

    Science.gov (United States)

    2012-02-28

    Stanfield, Electrodynamic Field of Dielectric Barrier Discharge, 17th International Conference on MHD Energy Conversion, Kanagawa, Japan, 14-17 July 2009...Application to Aerospace Science, The Aeronautical Journal , Vol. 113 No. 1148, Oct. 2009, pp. 619-632. 2. Peters, N., Length Scales in Laminar and...Kinetics,” AIAA Journal , Vol. 46, 2008, pp. 1640-1650. 10. Shang, J.S. and Katta, V.R., Vorticity Structure in Hydrogen-Air Jet Diffusion Flames

  10. Vice President Shen Wenqing Met JST Delegation

    Institute of Scientific and Technical Information of China (English)

    Zhang Yinglan

    2008-01-01

    @@ On May 19,2008,Prof.Shen Weqing,Vice President of NSFC,met with the delegation headed by Prof.Akira Fujishima,Director-General of China Research Center,Japan Science and Technology (JST).Prof.Fujishima is also the Chairman of Kanagawa Academy of Science and Technology,Japan and Foreign Member of the Chinese Academy of Sciences elected in 2003.

  11. 10th international conference on gas-liquid and gas-liquid-solid reactor engineering preface

    OpenAIRE

    J.A. Teixeira; Vicente, A. A.; Middelberg, A.P.J

    2011-01-01

    Following the success of the nine previous conferences on Gas–Liquid and Gas–Liquid–Solid reactor Engineering which were held at Columbus, OH, USA (1992), Cambridge, UK (1995), Kanagawa, Japan (1997), Delft, The Netherlands (1999), Melbourne, Australia (2001), Vancouver, Canada (2003), Strasbourg, France (2005), New Delhi, India (2007) and Montreal, Canada (2009) the tenth conference with the same theme is being held in Braga, Portugal, from 26 to 29 June 2011. This conference will cover all ...

  12. Thermo-Chemical Phenomena Simulation for Ablation

    Science.gov (United States)

    2011-02-21

    Mineola, NY, 2002, pp.107-348. 14. Surzhikov S.T. Radiation. Modeling and Spectral Data. Lecture series 2002-07: Physico-Chemical Models for...Barrier Discharge, 17th International Conference on MHD Energy Conversion, Kanagawa, Japan, 14-17 July 2009. 17. Shang, J.S., Computational... MHD Energy Conversion, 2009 AFRL Point of Contact Dr. Donald B. Paul, AFRL/RB WPAFB, OH 937-255-7329, met weekly. Dr. Richard Rivir, AFRL/RZ

  13. Eesti graafika välisnäitustel / Virge Jõekalda

    Index Scriptorium Estoniae

    Jõekalda, Virge

    1999-01-01

    1998. a. okt.-nov. Jaapanis Yokohamas toimunud Kanagawa V kunstifestivali graafikakonkursist. Eestist näitusel U. Viigi ja V. Jõekalda tööd. 1998. a. nov.-dets. Ljubljana Agart World Print Festivalist. Kuivnõeltehnika preemia V. Jõekaldale. Eestist eksponeeritud veel I. Heamäe, I. Kruusamäe ja B. Vassermani tööd. Peapreemiate saajad festivalidel

  14. Eesti graafika välisnäitustel / Virge Jõekalda

    Index Scriptorium Estoniae

    Jõekalda, Virge

    1999-01-01

    1998. a. okt.-nov. Jaapanis Yokohamas toimunud Kanagawa V kunstifestivali graafikakonkursist. Eestist näitusel U. Viigi ja V. Jõekalda tööd. 1998. a. nov.-dets. Ljubljana Agart World Print Festivalist. Kuivnõeltehnika preemia V. Jõekaldale. Eestist eksponeeritud veel I. Heamäe, I. Kruusamäe ja B. Vassermani tööd. Peapreemiate saajad festivalidel

  15. Jaapani graafika Tallinnas

    Index Scriptorium Estoniae

    2003-01-01

    Ku galeriis jaapani kaasaegse graafika näitus "Living Faces in Tallinn". Kouichi Kitamura kujundatud väljapanek tutvustab rühmituse Printsaurus kunstnike töid. Adamson-Ericu muuseumis näitus "300 aastat Jaapani puulõike traditsiooni. Ukiyo-e puulõiked meister Keizo Sato töökojast". 12. ja 13 IX esinevad näitusel Keizo Sato, tema assistent Makoto Nakayama, puulõikemeister Hiroshi Fujizawa ja ukiyo-e uurija kunstnik Tuula Moilanen. 12. IX loengud "Ukiyo-e puulõike maailm", 13. IX esitletakse ukiyo-e puulõiketehnikat

  16. Delineation of large localized damage structures forming ahead of an active mining front by using advanced acoustic emission mapping techniques

    CSIR Research Space (South Africa)

    Moriya, H

    2015-10-01

    Full Text Available Smuts Ave, Braamfontein 2000, Johannesburg, South Africa h Gesellschaft für Materialprüfung und Geophysik, Dieselstraße 9,61231 Bad Nauheim, Germany i Graduate School of Science, Tohoku University, 6-6 Aramaki aza aoba, Aoba-ku, Sendai 980-8578, Japan..., Gerrievan Aswegen c, Osamu Murakami d, Thabang Kgarume e, Anthony K. Ward f, Raymond J. Durrheimg, Joachim Philipp h, Yasuo Yabe i, Hironori Kawakata j, Hiroshi Ogasawara j a Graduate School of Engineering, Tohoku University, 6-6-04 Aobayama, Aoba...

  17. PÖFFi esimene seeria / Erkki Luuk

    Index Scriptorium Estoniae

    Luuk, Erkki, 1971-

    2002-01-01

    Pimedate Ööde filmifestivalil näidatud filme - animafilm "Ärgas elu" ("Waking Life") : režissöör Richard Linklater : Ameerika Ühendriigid 2001, mängufilm "Kana süda" 8"Chicken Heart") : režissöör Hiroshi Shimizu : Jaapan 2002 ja Ida-Saksamaa indiaanifilm "Chingachguk - Suur Madu" ("Chinachgook - die Grosse Schlange") : režissöör Richard Groschopp : 1967, mis oli üks serblasest filminäitleja Gojko Mitic'i retrospektiivi kuulunud filmidest

  18. Jaapani graafika Tallinnas

    Index Scriptorium Estoniae

    2003-01-01

    Ku galeriis jaapani kaasaegse graafika näitus "Living Faces in Tallinn". Kouichi Kitamura kujundatud väljapanek tutvustab rühmituse Printsaurus kunstnike töid. Adamson-Ericu muuseumis näitus "300 aastat Jaapani puulõike traditsiooni. Ukiyo-e puulõiked meister Keizo Sato töökojast". 12. ja 13 IX esinevad näitusel Keizo Sato, tema assistent Makoto Nakayama, puulõikemeister Hiroshi Fujizawa ja ukiyo-e uurija kunstnik Tuula Moilanen. 12. IX loengud "Ukiyo-e puulõike maailm", 13. IX esitletakse ukiyo-e puulõiketehnikat

  19. PÖFFi esimene seeria / Erkki Luuk

    Index Scriptorium Estoniae

    Luuk, Erkki, 1971-

    2002-01-01

    Pimedate Ööde filmifestivalil näidatud filme - animafilm "Ärgas elu" ("Waking Life") : režissöör Richard Linklater : Ameerika Ühendriigid 2001, mängufilm "Kana süda" 8"Chicken Heart") : režissöör Hiroshi Shimizu : Jaapan 2002 ja Ida-Saksamaa indiaanifilm "Chingachguk - Suur Madu" ("Chinachgook - die Grosse Schlange") : režissöör Richard Groschopp : 1967, mis oli üks serblasest filminäitleja Gojko Mitic'i retrospektiivi kuulunud filmidest

  20. Database Description - Plabrain DB | LSDB Archive [Life Science Database Archive metadata

    Lifescience Database Archive (English)

    Full Text Available ra, Tomomi Kudome, Osamu Nishimura, Hiroshi Tarui and Kiyokazu Agata Journal: Dev Growth Differ., 52, 131-14...ashi Taniguchi and Kiyokazu Agata Journal: Neuroscience, 168, 18-30 (2010) External Links: Article title: Pl...em Author name(s): Hiroyuki Takeda, Kaneyasu Nishimura and Kiyokazu Agata Journal: Zoolog. Sci., 26, 805-813...Takeshi Inoue, Yoshihiko Umesono, Kanji Yoshimoto, Takashi Taniguchi and Kiyokazu Agata Journal: Dev Growth ...Takashi Taniguchi and Kiyokazu Agata Journal: Neurosci. Res., 59, 101-106 (2007)

  1. Investigation of deep levels in bulk GaN

    OpenAIRE

    2014-01-01

    The first gallium nitride (GaN) crystal was grown by hydride vapor phase epitaxy in 1969 by Maruska and Tietjen and since then, there has been an intensive development of the field, especially after the ground breaking discoveries concerning growth and p-type doping of GaN done by the 2014 year Nobel Laureates in Physics, Isamu Akasaki, Hiroshi Amano and Shuji Nakamura. GaN and its alloys with In and Al belong to a semiconductor group which is referred as the III-nitrides. It has outstanding ...

  2. Geometrical design and measurement of light-emitting diode for lighting

    OpenAIRE

    Cheung, Wing-shing; 章永聖

    2015-01-01

    Year 2014 is a milestone in the history of LEDs industry. Isamu Akasaki, Hiroshi Amano and Shuji Nakamura were awarded the Nobel Prize in Physics 2014 for their contribution in the application of “bright and energy-saving white light sources” with invention of efficient blue indium gallium nitrate (InGaN) light-emitting diodes (LED) [1]. This can be treated as an admission of the impotence of LED lighting in the modern human civilization. Although the LED- related technologies had been we...

  3. Background story of the invention of efficient blue InGaN light emitting diodes

    Energy Technology Data Exchange (ETDEWEB)

    Nakamura, Shuji [University of California, Santa Barbara, CA (United States)

    2015-06-15

    Shuji Nakamura discovered p-type doping in Gallium Nitride (GaN) and developed blue, green, and white InGaN based light emitting diodes (LEDs) and blue laser diodes (LDs). His inventions made possible energy efficient, solid-state lighting systems and enabled the next generation of optical storage. Together with Isamu Akasaki and Hiroshi Amano, he is one of the three recipients of the 2014 Nobel Prize in Physics. In his Nobel lecture, Shuji Nakamura gives an overview of this research and the story of his inventions. (copyright 2015 by WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  4. Toxicity of Thiophenes from Echinops transiliensis (Asteraceae) against Aedes aegypti (Diptera: Culicidae) Larvae

    Science.gov (United States)

    2014-01-01

    Toxicity of Thiophenes from Echinops transiliensis (Asteraceae) against Aedes aegypti (Diptera: Culicidae) Larvae by Hiroshi Nakano*a)b)c), Abbas...larvicides against Aedes aegypti . Structural differences among compounds 3, 5, and 8 consisted in differing AcO and OH groups attached to C(3’’) and C(4...mg/ml), 4 (LC50 , 17.95 mg/ml), 6 (LC50 , 18.55 mg/ml), and 7 (LC50 , 19.97 mg/ml). These data indicated that A. aegypti larvicidal activities of

  5. Phenotype-gene: 1 [Arabidopsis Phenome Database[Archive

    Lifescience Database Archive (English)

    Full Text Available 1 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1000i colorless cotyle...don for AT3G19220 Shimada Hiroshi et al. 2007 Oct. Plant Cell 19(10):3157-69. http://metadb.riken.jp/db/SciN...etS_ria224i/cria224u4ria224u17921316i colorless cotyledon http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u601i AT3G19220

  6. The Structure of Optimum Interpolation Functions.

    Science.gov (United States)

    1983-02-01

    Daniel F . Merriam, ed., Plenum Press, 1970. 2. Hiroshi Akima, "Comments on ’Optimal Contour Mapping Using Universal Kriging’ by Ricardo 0. Olea," (with...Interpolation Scheme," Monthly WeatherReview 109 (1981), 701-721. 22. A. Marechal and J. Serra, "Random Kriging,"pp. 91-112 in Geostatistics, Daniel F . Merriam...ed., Plenum Press, 1970. 23. G. Matheron, "Random Functions and Their Applications in Geology," pp. 79-87 in Geostatistics, Daniel F . Merriam

  7. Materials Research Society Symposium on the Electrical, Optical and Magnetic Properties of Organic Solid State Materials Held in Boston Massachusetts on 27 November-2 December 1989

    Science.gov (United States)

    1989-12-01

    THIN A TECHNIQUE FOR BRAZING ALUMINUM FILM OF POLYIMIDE, Yoshiro Akai, Mariko NITRIDE SUBSTRATES, M. Grant Norton, Cornell Ishino, Yasunari Okaoto...Yoshiro Akagi, Mariko Ishino, Yasunari Okamoto temperature thermal conductivity is inhibited Hiroshi Taniguchi, KohJi Ooka, Yoshiharu Nakajima...NISHIWAXI, R.. 147.247 OKANO. YOSHINXIi, 08.3, 013.4 PAJEVIC. S., T7.26 M3, 143.1, 145.9, 17.59, 447.185, NINA, K., K5.11 OKAOTO, YASUNARI , K5.12 PAJOT

  8. 前生命期保护

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    发现日本理化研究所的Hiroshi Ohno注意到一些细菌品系可以保护小鼠免受致命的0157大肠杆菌感染的危害。Ohno打算一探究竟。他发现那些有保护作用的细菌能表达一种转运蛋白.可以让小鼠产生乙酸盐.抑制受感染的细胞摄入志贺毒素。

  9. [Effectiveness of expression of tdh gene of Vibrio parahaemolyticus depends on two point mutations in promoter region].

    Science.gov (United States)

    Shalu, O A; Pisanov, R V; Monakhova, E V

    2012-12-01

    A molecular-biological study of the clinical strains of Vibrio parahaemolyticus that contain genes of thermostable direct hemolysin Tdh) and Tdh-related hemolysin (Trh). Using Southern blot hybridization, it is shown that genomes of strains that carry determinants of both hemolysins (tdh(+)-trh+) represent a single copy, whereas in tdh2+RH+ strains, there are two copies (tdh1 and tdh2). All of the examined tdh+trh+ and some of the tdh+trh strains either did not express the tdh gene or did not express the tdh gene (Kanagawa negative or KP-) or expressed it weakly and not often (Kanagawa intermediate, KP+), unlike several Kanagawa positive tdh+trh- strains. To establish the reasons for KP -/+ phenotypes, tdh, tdh11, and tdh2 genes of 13 strains isolated in Russia and neighboring foreign countries were sequenced, followed by the biotransformation analysis of the obtained sequences, as well as a comparison with those of a number of strains presented in GenBank. The results revealed that the weak expression of the tdh gene depends, not only on one point mutation in the promoter region (substitution of A for G in the -35 region), as was thought previously, but also on the second substitution (G for A in the -3 position relative to the -10 sequence), which is quite sufficient when the former is absent. Therefore, the reversion of KP -/+ strains that contain one of these substitutions can take place as a result of a single reverse point mutation, and they should be considered potentially dangerous. Strains that contain both substitutions may revert with lesser probability because, in this case, both mutations are necessary.

  10. Genetic characterisation of influenza C viruses detected in Singapore in 2006.

    Science.gov (United States)

    Ting, Pei-jun; Seah, Shirley Gek-Kheng; Lim, Elizabeth Ai-Sim; Liaw, Jasper Chin-Wen; Boon-Huan, Tan

    2016-01-01

    In an earlier study on respiratory infections in Singapore military recruits, four influenza C virus (FLUCV) infections were detected out of the 1354 samples collected. All four isolates were detected in 2006, and their whole genome was completely sequenced and analysed. Phylogenetic analysis of the hemagglutinin esterase fusion (HEF) gene revealed that all four Singapore isolates belonged to the C/Japan-Kanagawa/1/76-related lineage. However, the genes of the four FLUCV isolates had origins from several different lineages, and the genome composition resembles that of the C/Japan-Miyagi/9/96-like strains that had been circulating in Japan between 1996 and 2000.

  11. Determination of Phylogenetic Relationship Among Vibrio Parahaemolyticus Isolates from Persian Gulf and the Evaluation of their Susceptibility to Antibiotics

    Directory of Open Access Journals (Sweden)

    S Haghnegahdar

    2016-09-01

    Full Text Available Background & aim: Vibrio parahaemolyticus is a Gram negative halophilic bacterium found in aquatic environments. This bacterium has been introduced as a cause of acute gastroenteritis following the consumption of raw and uncooked seafood. Major symptoms of Vibrio parahaemolyticus illness is watery diarrhea, abdominal cramps, Nausea, Vomiting, Fever, Headache and Bloody diarrhea. The purpose of this study was isolation and identification of Vibrio parahaemolyticus from Persian Gulf and the determination of their phylogenetic relationship. In addition, antibiotic susceptibility of the isolates was evaluated in order to achieve maximum information concerning a drug of choice. Methods: In this study, 89 samples of water, sediments, fish and shrimp were collected from different regions of the Persian Gulf. All samples were asssessed for phenotypic and molecular isolation and identification of Vibrio parahaemolyticus. Then the positive and negative  strains of conagua vibrio parahaemolyticus were determined based on hemolysin production. the identification and phylogenetic relationship  were  analyzed using the mega-6 software. Finally susceptibility of Kanagawa positive Vibrio parahaemolyticus to antibiotics was evaluated by disk diffusion method and minimal inhibitory concentrations of effective antibiotics were assessed using double serial dilution method. Results: A total of nine Vibrio parahaemolyticus were isolated and identified. Of all isolates five strains were Kanagawa positive and four were Kanagawa negative. All isolates exhibited phylogenetic relationship to each other except one strain (NSP1. The results obtained from antibiotic susceptibility of Kanagawa positive  Vibrio parahaemolyticus isolates illustrated that most of the isolates were resistance to Vancomycin, Oxacillin, and Amikacin and susceptible to Trimetoprim Sulfometaxazole respectively. In addition, the lowest Minimal inhibitory Concentration (MIC value was found for

  12. Perivertebral B-cell lymphoma in a Queensland koala (Phascolarctos cinereus adustus) with paralytic symptoms in the hind limbs.

    Science.gov (United States)

    Kido, Nobuhide; Edamura, Kazuya; Inoue, Naomi; Shibuya, Hisashi; Sato, Tsuneo; Kondo, Masako; Shindo, Izumi

    2012-08-01

    A male Queensland koala (Phascolarctos cinereus adustus) at Kanazawa Zoological Gardens (Kanagawa, Japan) exhibited paralytic symptoms in the hind limbs. Computed tomography and magnetic resonance imaging revealed a mass on the left ventral side of the 11th to 13th thoracic vertebrae, and the presence of myelitis or edema in the spinal cord. The koala was under anesthesia during the examination and suddenly developed ventricular fibrillation and died. Necropsy revealed a firm flat ovoid hemorrhagic mass on the vertebrae. Following a microscopic examination including immunohistochemistry, the perivertebral mass was diagnosed as B cell lymphoma. Therefore, neoplastic cell infiltration into the spinal cord may cause paralytic symptoms in the hind limbs.

  13. Vibrio parahaemolyticus produtores de urease isolados a partir de ostras (Crassostrea rizophorae coletadas in natura em restaurantes e mexilhões (Perna perna de banco natural Vibrio parahaemolyticus urease positive isolated from in natura oysters (Crassostrea rizophorae collected at restaurants and mussels (Perna perna harvested from natural habitat

    Directory of Open Access Journals (Sweden)

    Chistiane Soares Pereira

    2004-12-01

    Full Text Available A presença de Vibrio parahaemolyticus foi avaliada em 50 amostras de moluscos bivalves marinhos compostas por 40 amostras de ostras coletadas em 15 restaurantes do Rio de Janeiro e 10 amostras de mexilhões capturados de banco natural em Ponta de Itaipú - Niterói. Foram empregadas a técnica do Número Mais Provável (NMP para a enumeração de V. parahaemolyticus utilizando Caldo Glicosado Salgado com Teepol (GSTB e Água Peptonada Alcalina (APA com 3% de cloreto de sódio (NaCl. Paralelamente foi realizada técnica de enriquecimento em APA com 1 e 3% de NaCl. Decorrido o período de incubação de ambas as técnicas, foi realizado plaqueamento em ágar TCBS (Tiossulfato Citrato Bile Sacarose. Todas as cepas de V. parahaemolyticus isoladas através das duas técnicas foram testadas para o fenômeno de Kanagawa e, quanto à produção de urease. Do total de 141 cepas de V. parahaemolyticus isoladas, 62% revelaram-se urease positivas e, dentre estas, os sorotipos predominantes foram O10:K?, O11:K? e O3:K57 dentre o total de 24 sorotipos urease positivos identificados. Embora todas as cepas de V. parahaemolyticus tenham sido Kanagawa negativas, os resultados apontam elevada incidência desta espécie em ostras comercializadas em restaurantes.The presence of Vibrio parahaemolyticus were detected in 50 marine bivalve mollusks composed by 40 oysters samples collected at 15 restaurants in Rio de Janeiro City and 10 wild mussels' samples harvested in Ponta de Itaipu-Niterói. The Most Probable Number (MPN technique was employed for the enumeration of V. parahaemolyticus, using glucose salt teepol broth (GSTB and alcaline peptone water (APW with 3% NaCl. At the same time, the samples were submitted on direct plating with APW added 1 and 3% NaCl. Both techniques were followed by plating onto TCBS agar. All the V. parahaemolyticus strains isolated were tested for Kanagawa phenomenon and they were also tested for the presence of urease. A total of 141 V

  14. 20世纪日本对自杀问题的相关研究述评%Review on Suicide -related Studies in Japan in the 20th Century

    Institute of Scientific and Technical Information of China (English)

    李建军

    2012-01-01

    Research on " suicidology" is quite advanced in Japan. In the 20th century, suiciderelated studies were carried out very early by a large number of researchers in Japan and have produced abundant research results. After the Second World War, the academic research on suicide has reached its summit with the arrival of three "suicide peaks" in Japan. The research findings achieved by Kenshiro Ohara, Hiroshi Inamura, Yoshimoto Takahashi, and Hiroshi Kawato are representative in this field. The research methods and results in Japan are of certain referential value to the corresponding research in China.%日本的"自杀学"研究较为发达。在20世纪日本的相关研究起步早、研究人员多、成果丰硕。战后,伴随着日本发生的三次"自杀高峰",学界的研究也进入了高潮。大原健士郎、稲村博、高桥祥友、川人博等人的研究成果具有代表性。日本的研究方法和成果对我国的相关研究具有一定的参考价值。

  15. Antibiotic resistance of Vibrio parahaemolyticus isolated from pond-reared Litopenaeus vannamei marketed in Natal, Brazil

    Directory of Open Access Journals (Sweden)

    Ligia Maria Rodrigues de Melo

    2011-12-01

    Full Text Available Ten out of fifty fresh and refrigerated samples of shrimp (Litopenaeus vannamei collected from retailers in Natal (Rio Grande do Norte, Northeastern Brazil tested positive for Vibrio parahaemolyticus. The Kanagawa test and multiplex PCR assays were used to detect TDH and TRH hemolysins and the tdh, trh and tlh genes, respectively. All strains were Kanagawa-negative and tlh-positive. Antibiotic susceptibility testing was done for seven antibiotics by the agar diffusion technique. Five strains (50% presented multiple antibiotic resistance to ampicillin (90% and amikacin (60%, while two strains (20% displayed intermediate-level resistance to amikacin. All strains were sensitive to chloramphenicol. Intermediate-level susceptibility and/or resistance to other antibiotics ranged from 10 to 90%, with emphasis on the observed growing intermediate-level resistance to ciprofloxacin. Half our isolates yielded a multiple antibiotic resistance index above 0.2 (range: 0.14-0.29, indicating a considerable risk of propagation of antibiotic resistance throughout the food chain.

  16. [Levels of thermostable direct hemolysin production by Vibrio parahaemolyticus strains carrying both tdh and trh genes].

    Science.gov (United States)

    Suzuki, N; Hashimoto, S; Ishibashi, M; Kim, Y B; Okuda, J; Nishibuchi, M

    1997-12-01

    One hundred and twenty-five strains of Vibrio parahaemolyticus carrying both the tdh and trh genes were selected from the strains isolated from the travelers with diarrhea by an hybridization test using polynucleotide probes. The levels of TDH produced by these strains and the association between the TDH levels and related characteristics in these strains were analyzed. The TDH level varied greatly from strain to strain, but none of the levels was as high as that of the typical Kanagawa phenomenon-positive strains. The strains were classified into "TDH producer" (18 strains), "Low-level TDH producer" (85 strains), and "No TDH producer" (22 strains) based on the results of a modified Elek test and the hemolysis assay on Wagatsuma agar. The highest TDH level achieved by the "TDH producer" was twofold lower than that of the Kanagawa phenomenon-positive strains as assayed by the RPLA method. All strains possessed the toxR gene. The trh1 and trh2 genes were detected in, respectively, 105 and 20 strains, and no correlation existed between the type of the trh gene and the levels of TDH produced. Considerable restriction fragment length polymorphism was observed with the tdh gene-bearing HindIII DNA fragment in different strains, but it was not related with the TDH level.

  17. Vibrio parahaemolyticus- An emerging foodborne pathogen

    Directory of Open Access Journals (Sweden)

    S Nelapati

    2012-02-01

    Full Text Available Vibrio parahaemolyticus is a halophilic gram negative, motile, oxidase positive, straight or curved rod-shaped, facultative anaerobic bacteria that occur naturally in the marine environment. They form part of the indigenous microflora of aquatic habitats of various salinity and are the major causative agents for some of the most serious diseases in fish, shellfish and penacid shrimp. This human pathogen causes acute gastroenteritis characterized by diarrhea, vomiting and abdominal cramps through consumption of contaminated raw fish or shellfish. V. parahaemolyticus is the leading cause of gastroenteritis due to the consumption of seafood worldwide. The incidence of V. parahaemolyticus infection has been increasing in many parts of the world, due to the emergence of O3:K6 serotype carrying the tdh gene which is responsible for most outbreaks worldwide. The pathogenicity of this organism is closely correlated with the Kanagawa phenomenon (KP + due to production of Kanagawa hemolysin or the thermostable direct hemolysin (TDH. The TDH and TRH (TDH-related hemolysin encoded by tdh and trh genes are considered to be important virulence factors. [Vet. World 2012; 5(1.000: 48-63

  18. Five species of the family Cyproideidae (Crustacea: Amphipoda) from Japan, with the description of a new genus and two new species.

    Science.gov (United States)

    Ariyama, Hiroyuki

    2016-03-31

    Five species of the family Cyproideidae (Crustacea: Amphipoda) are described from shallow sea in Japan. Cyproidea liodactyla Hirayama, 1978 was collected from Kanagawa and Shizuoka Prefectures and Ariake Sea. Morphological character of the antenna 1 in these specimens is different from the original description. Examining the paratypes of C. liodactyla, the shape of the antenna 1 in the holotype is revealed to be abnormal. Cyproidea okinawensis sp. nov. was collected from Okinawa Island. Its morphological characters resemble C. liodactyla and C. robusta Ren, 2006; however, this new species is different from the former in the smaller eyes, the narrower coxa 5 and the coloration, and from the latter in the ovoid telson. Metacyproidea gen. nov. is established with M. makie sp. nov. from Hachijo Island in Tokyo Prefecture as its type species. This new genus resembles Cyproidea, especially in the peduncular article 2 of antenna 1 with a distinct distal tooth and the posterodorsal end of urosomites with a strong projection. However, Metacyproidea can be distinguished from Cyproidea by the coalesced urosomites 2-3 and the antenna 1 with a 10-16-articulated flagellum. Moolapheonoides acutifalcatus Kobayashi & Ishimaru, 2005 and Terepeltopes dolichorhunia Hirayama, 1983 were also collected from Wakayama and Fukui Prefectures and Kanagawa, Shizuoka and Yamaguchi Prefectures, respectively. A key to species of the family Cyproideidae in Japan is provided.

  19. Trends in occurrence of twin births in Japan.

    Science.gov (United States)

    Kurosawa, Kenji; Masuno, Mitsuo; Kuroki, Yoshikazu

    2012-01-01

    The rise in the rate of multiple births since the 1980s is due to the effect of advanced maternal age and increased use of assisted reproductive technology (ART). To determine the trends of prevalence in twin births, we studied the data of a population-based birth defects monitoring system during 26 years in Kanagawa Prefecture, Japan. A total of 15,380 twins from 7,690 deliveries were ascertained from 990,978 births in the Kanagawa Birth Defects Monitoring Program (KAMP) during 1981-2008. From the start of KAMP in 1981, the incidence of twin births had been consistently increasing from 57.0 to 98.6 per 10,000 deliveries until 2003, but after this time, the incidence declined to 78.5 in 2007. While the rate of monozygotic twins has been stable (∼40 per 10,000 deliveries) after 1990, that of dizygotic twins increased from 25.3 to 57.3 per 10,000 deliveries until 2002, and recovered to 40.1 in 2007. These results showed the most recent tendency of twin births and indicated that the single embryo transfer method can provide protection and reduction of perinatal risk caused by multiple births.

  20. PREFACE: Nanospintronics design and realization

    Science.gov (United States)

    Akai, Hisazumi; Katayama-Yoshida, Hiroshi; Kasai, Hideaki

    2004-12-01

    This special issue of Journal of Physics: Condensed Matter contains selected papers from the 1st International Conference on Nanospintronics Design and Realization (ICNDR 2004), which was held in Kyoto, Japan, 24--28 May 2004. This conference was organized by the Nanospintronics Design and Realization project members: Hideaki Kasai, Osaka (Chair of the Conference) Hisazumi Akai, Osaka Hajime Asahi, Osaka Wilson Agerico Diño, Osaka Hiroshi Harima, Kyoto Tomoyuki Kakeshita, Osaka Junjiro Kanamori, Kyoto Hiroshi Katayama-Yoshida, Osaka Koichi Kusakabe, Osaka Hiroshi Nakanishi, Osaka (Secretary) Tamio Oguchi, Hiroshima Teruo Ono, Osaka Naoshi Suzuki, Osaka Hitoshi Tabata, Osaka under the auspices of the Japan Ministry of Education, Culture, Sports, Science and Technology (MEXT) Special Coordination Funds for Promoting Science and Technology, and the sponsorship of Osaka University and the International Institute for Advanced Studies (IIAS). The conference is intended to provide an international forum for experimental and theoretical researchers, in the rapidly developing field of nanospintronics. It aims to: provide an overview of our current understanding of the physics of spin transport in (magnetic) semiconductors and hybrid magnetic/semiconductor structures; provide a venue to present and discuss the latest developments in using spin-dependent phenomena in nano-(opto-) electronics and computing applications; provide a venue for discussion and assessment of other possible means of exploiting the spin-dependent phenomena in future nano-(opto-) electronic and computing applications; address current (and foreseeable future) problems, of fundamental and applied nature, in an effort to bridge the physics and technology gap between semiconducting and magnetic materials. All of these being geared towards bringing about the realization of a functioning nanospintronics. A total of 127 delegates from 15 countries took part in ICNDR 2004, which was comprised of 62 invited

  1. Oxidized galectin-1 reduces lipopolysaccharide-induced increase of proinflammatory cytokine mRNA in cultured macrophages

    Directory of Open Access Journals (Sweden)

    Yukie Kogawa

    2011-01-01

    Full Text Available Yukie Kogawa1, Kou Nakajima1, Kenichi Sasaguri1, Nobushiro Hamada2, Haruhisa Kawasaki3, Sadao Sato1, Toshihiko Kadoya4, Hidenori Horie51Department of Orthodontics, 2Department of Oral Microbiology, Kanagawa Dental College, Yokosuka; 3Keio University, Kanagawa; 4Maebashi Institute of Technology, Maebashi; 5Research Center of Brain and Oral Science, Kanagawa Dental College, Yokosuka, JapanBackground: Periodontitis is prevalent in older humans. Limiting the inflammation associated with periodontitis may provide a therapy for this condition, because Gram-negative bacteria expressing lipopolysaccharide (LPS have a key role in initiation of inflammation by activating macrophage functions. Because oxidized galectin-1 regulates macrophage functions in other systems, we sought to establish whether this galectin-1 mRNA is expressed in the oral cavity, and whether it could dampen LPS-induced macrophage activation in vitro.Methods: Using the reverse transcriptase polymerase chain reaction (RT-PCR, we measured galectin-1 mRNA expression to clarify its localization to rat gingival tissues and studied the effect of Porphyromonas gingivalis challenge on galectin-1 expression. Next, we tested the effects of adding oxidized galectin-1 to cultured LPS-activated peritoneal macrophages on mRNA expression of proinflammatory factors by RT-PCR and real-time RT-PCR.Results: We established that galectin-1 mRNA is expressed in gingival tissues and also showed that galectin-1 mRNA was significantly increased by challenge with P. gingivalis, indicating that galectin-1 may regulate oral inflammation. On the other hand, LPS 100 ng/mL in serum-containing medium induced macrophages to upregulate mRNA associated with a proinflammatory response, ie, interleukins 1β and 6, and inducible nitric oxide synthase. We showed that application of 0.1–10 ng/mL of oxidized galectin-1 to LPS-treated macrophages reduced the intense LPS-induced increase by serum in proinflammatory m

  2. Economic dynamics with financial fragility and mean-field interaction: A model

    Science.gov (United States)

    Di Guilmi, C.; Gallegati, M.; Landini, S.

    2008-06-01

    Following Aoki’s statistical mechanics methodology [Masanao Aoki, New Approaches to Macroeconomic Modeling, Cambridge University Press, 1996; Masanao Aoki, Modeling Aggregate Behaviour and Fluctuations in Economics, Cambridge University Press, 2002; Masanao Aoki, and Hiroshi Yoshikawa, Reconstructing Macroeconomics, Cambridge University Press, 2006], we provide some insights into the well-known works of [Bruce Greenwald, Joseph Stiglitz, Macroeconomic models with equity and credit rationing, in: R. Hubbard (Ed.), Information, Capital Markets and Investment, Chicago University Press, Chicago, 1990; Bruce Greenwald, Joseph Stiglitz, Financial markets imperfections and business cycles, Quarterly journal of Economics (1993)]. Specifically, we reach analytically a closed form solution of their models overcoming the aggregation problem. The key idea is to represent the economy as an evolving complex system, composed by heterogeneous interacting agents, that can be partitioned into a space of macroscopic states. This meso level of aggregation permits to adopt mean-field interaction modeling and master equation techniques.

  3. Successful administration of venovenous extracorporeal membrane oxygenation through the modified Blalock–Taussig operation in an infant with graft dysfunction after the Norwood procedure

    Directory of Open Access Journals (Sweden)

    Kanao-Kanda M

    2015-10-01

    Full Text Available Megumi Kanao-Kanda, Takayuki Kunisawa, Kunihiko Yamamoto, Hirotsugu Kanda, Hiroshi Iwasaki Department of Anesthesiology and Critical Care Medicine, Asahikawa Medical University, Asahikawa, Hokkaido, JapanInsufficient pulmonary blood flow through a right ventricle-to-pulmonary artery conduit following the Norwood procedure is remediable by adding a modified Blalock–Taussig shunt (MBTS.1 First, however, perioperative hypoxemia must be managed. Venovenous extracorporeal membrane oxygenation (VV-ECMO is likely to be a useful method for respiratory support in such cases.2,3 We present the case of a 2-month-old patient with graft dysfunction after the Norwood procedure who underwent MBTS with VV-ECMO support. 

  4. Tela em branco: cinema da origem,origem do cinema

    Directory of Open Access Journals (Sweden)

    André Brasil

    2009-06-01

    Full Text Available Por meio da tela em branco que aparece em três filmes (Zen for film, de Nam June Paik, Scénario du film Passion, de Jean-Luc Godard, e Onde jaz o teu sorriso?, de Pedro Costa e em um projeto fotográfico (Theatres, de Hiroshi Sugimoto, abordamos o conceito de origem na perspectiva de Walter Benjamin. Em sua abertura e inacabamento, a origem só pode se restituir no futuro, por um trabalho da memória, que se define como recriação a partir de vestígios da história. Aqui se busca um cinema da origem (diferente de um cinema das origens, em cujo saber se abriga sempre um não-saber originário. Nós o encontraremos na tela em branco, nos modos diversos como ela surge em cada uma destas obras.

  5. Panel established to revise position statement on climate change

    Science.gov (United States)

    President Robert Dickinson has appointed a panel to review the current AGU position statement on climate change and greenhouse gases, and to consider revising the statement to reflect scientific progress over the last four years. Marvin Geller of the State University of New York-Stonybrook chairs the panel.Other panel members include: Andre Berger, George Lemaître Catholic University of Louvain, Belgium; Anny Cazenave, Observatoire Midi-Pyrénées, Toulouse, France; John Christy, University of Alabama, Huntsville; Ellen Druffel, University of California, Irvine; Jack Fellows, University Consortium for Atmospheric Research, Boulder; Hiroshi Kanzawa, Nagoya University, Japan; William Schlesinger, Duke University, Durham; William (Jim) Shuttleworth, University of Arizona; Eric Sundquist, U.S. Geological Survey, Woods Hole; Richard Turco, University of California, Los Angeles; Ilana Wainer, Universidade Cidade Sao Paulo, Brazil.

  6. Acute pyogenic discitis in a degenerative intervertebral disc in an adult

    Directory of Open Access Journals (Sweden)

    Masamitsu Tanaka

    2010-08-01

    Full Text Available Masamitsu Tanaka1,2, Hiroshi Shimizu2, Yoshiyuki Yato1, Takashi Asazuma1, Koichi Nemoto11Department of Orthopedic Surgery, National Defense Medical College, Tokorozawa, Saitama; 2Department of Orthopedic Surgery, Self Defense Force Fukuoka Hospital, Kasuga, Fukuoka, JapanAbstract: A 35-year-old male who had been receiving conservative treatment for L4 isthmic spondylolisthesis suffered from pyogenic spondylodiscitis in the degenerative L4/L5 intervertebral disc space, which could be identified by comparison with previous images. Symptoms improved with conservative antibiotic treatment. Neovascularization may occur in the annulus fibrosus of a degenerative intervertebral disc, which may increase the risk of hematogenous infection, leading to “discitis” even in adults.Keywords: spondylodiscitis, spondylitis, discitis, isthmic spondylolisthesis, spondylolysis, intervertebral disc degeneration

  7. Use of the phaco tip technique for lens cleavage and removal during cataract surgery

    Directory of Open Access Journals (Sweden)

    Masuda Y

    2016-10-01

    Full Text Available Yoichiro Masuda,1 Kotaro Oki,2 Hisaharu Iwaki,3 Toshinori Okamoto,1 Hiroshi Tsuneoka4 1Department of Ophthalmology, Jikei University Katsushika Medical Center, 2Oki Eye Surgery Center, 3Iwaki Eye Clinic, 4Department of Ophthalmology, Jikei University School of Medicine, Tokyo, Japan Abstract: Use of the phaco tip technique for lens cleavage and removal does not require manual hydrodissection using a syringe and cannula, or cortical removal using an irrigation/aspiration tip. The phaco tip is the only surgical instrument required for this technique. Its advantages include maintaining a stable intraocular pressure during cortical cleaving hydrodissection and lens removal, which includes the cortex. Keywords: cataract surgery, hydrodissection, capsular block syndrome, FLACS, Dewey tip

  8. [The growing-up and background of clinical neurology in Japan].

    Science.gov (United States)

    Takahashi, Akira

    2002-11-01

    Japan strictly closed the country to foreigners except for the Dutch and Chinese in the days of Tokugawa Regime for about 200 years (1639-1858). During this period, Japanese neurology made a start. In 1774, five Dutch scholars in Edo (Tokyo at present) translated the Dutch version of a German textbook "Anatomische Tabellen". After the Meiji Restoration, Japan was rapidly westernized. The modern neurology was introduced mainly from Germany, France and the United Kingdom into Japan, and exerted a fruitful influence on the subsequent Japanese neurology. Prof. Hiroshi KAWAHARA published the first textbook of neurology (in Japanese) in 1897. Prof. Kinnosuke MIURA founded the first neurological journal in Japan in 1902. These two pioneers in Japanese neurology had their medical education under Prof. Erwin Baelz at the University of Tokyo during the last-eighteenth century.

  9. Biography of Akira Tonomura (April 1942 - May 2012)

    Science.gov (United States)

    Osakabe, Nobuyuki

    2014-01-01

    Akira Tonomura was born on 25 April 1942 in Hyogo Prefecture, Japan. He graduated from the Department of Physics in the University of Tokyo in 1965 and immediately joined the Central Research Laboratory of Hitachi, Ltd. Tonomura was motivated to join the lab because of Hiroshi Watanabe,1 who, with a single electron micrograph, proved the Bohm-Pines plasma oscillation theory2 by using electron energy-loss spectroscopy. On the recommendation of Watanabe, Tonomura pursued research with electron beams to achieve holography, invented by Dennis Gabor3 in 1948. Tonomura frequently communicated with Gabor, who encouraged him to realize aberration correction using electron holography, something that Gabor himself wanted to do, but he lacked a coherent electron source when he was doing his own research...

  10. Models of alcoholic liver disease in rodents: a critical evaluation

    DEFF Research Database (Denmark)

    de la M. Hall, P.; Lieber, C.S.; De Carli, L.M.

    2001-01-01

    This article represents the proceedings of a workshop at the 2000 ISBRA Meeting in Yokohama, Japan. The chairs were J. Christian Bode and Hiroshi Fukui. The presentations were (1) Essentials and the course of the pathological spectrum of alcoholic liver disease in humans, by P. de la M. Hall; (2......) Lieber-DeCarli liquid diet for alcohol-induced liver injury in rats, by C. S. Lieber and L. M. DeCarli; (3) Tsukamoto-French model of alcoholic liver injury, by S. W. French; (4) Animal models to study endotoxin-ethanol interactions, by K. O. Lindros and H. Järveläinen; and (5) Jejunoileal bypass...... operation in rats-A model for alcohol-induced liver injury? by Christiane Bode, Alexandr Parlesak, and J. Christian Bode....

  11. Successful resection of large mediastinal mature cystic teratoma immediately after evacuation of fluid content

    Directory of Open Access Journals (Sweden)

    Ryo Miyahara

    2010-11-01

    Full Text Available Ryo Miyahara, Shinjiro Nagai, Toshihiko Sato, Chen Fengshi, Toru Bando, Kenichi Okubo, Hiroshi DateDepartment of Thoracic Surgery, Kyoto University, Kyoto, JapanAbstract: In this report, we presented a case of urgent resection of mature giant mediastinal teratoma. Its characteristic radiologic findings allowed us to plan evacuation of intratumoral fluid in order to make the surgical procedure safe and less invasive. In addition, a hybrid thoracoscopic-open approach also provided safety and allowed a somewhat less invasive tumor resection than otherwise would have been required. The patient recovered well without recurrence at nine months’ follow-up, with full expansion of the right middle and lower lobes. Here we discuss the diagnosis and surgical procedure with reference to the literature.Keywords: mediastinal mature teratoma, rupture, acute pleuritis

  12. Hemorrhagic infarction at 33 days after birth in a healthy full-term neonate

    Directory of Open Access Journals (Sweden)

    Kubo Y

    2011-11-01

    Full Text Available Yoshitaka Kubo1, Kuniaki Ogasawara1, Akira Kurose2, Hiroshi Kashimura1, Takahiro Koji1, Yasunari Otawara1, Jun Kamei3, Manami Akasaka3, Makoto Sasaki4, Akira Ogawa1 1Department of Neurosurgery, 2Department of Pathology, 3Department of Pediatrics, 4Department of Radiology, Iwate Medical University, Morioka, Japan Abstract: Intraparenchymal hemorrhage in the full-term neonate rarely occurs more than 2 weeks after birth, and its definitive cause remains unclear. In the present report, a case of a patient with intraparenchymal hemorrhage occurring 33 days after birth is described. Histological examination of the brain tissue obtained during hematoma evacuation through craniotomy showed hemorrhagic infarction. Patent foramen ovale may have been present and this may have led to spontaneous paradoxical cerebral embolism followed by hemorrhagic infarction. Keywords: full-term neonate, hemorrhagic cerebral infarction, patent foramen ovale, surgery

  13. Tela em branco: cinema da origem,origem do cinema

    OpenAIRE

    André Brasil

    2009-01-01

    Por meio da tela em branco que aparece em três filmes (Zen for film, de Nam June Paik, Scénario du film Passion, de Jean-Luc Godard, e Onde jaz o teu sorriso?, de Pedro Costa) e em um projeto fotográfico (Theatres, de Hiroshi Sugimoto), abordamos o conceito de origem na perspectiva de Walter Benjamin. Em sua abertura e inacabamento, a origem só pode se restituir no futuro, por um trabalho da memória, que se define como recriação a partir de vestígios da história. Aqui se busca um cinema da or...

  14. Presumed toxoplasmic central retinal artery occlusion and multifocal retinitis with perivascular sheathing

    Directory of Open Access Journals (Sweden)

    Arai H

    2014-04-01

    Full Text Available Haruka Arai,1 Tsutomu Sakai,1 Kiichiro Okano,1 Ranko Aoyagi,1 Ayano Imai,2 Hiroshi Takase,2 Manabu Mochizuki,2 Hiroshi Tsuneoka11Department of Ophthalmology, Jikei University School of Medicine, Tokyo, Japan; 2Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, JapanAbstract: Central retinal artery occlusion (CRAO and multifocal retinitis with perivascular sheathing are rare in ocular toxoplasmosis. We report a case of toxoplasmic CRAO and multifocal retinitis with perivascular sheathing. A healthy 83-year-old male developed left panuveitis. Funduscopic examination of the left eye showed a swollen optic disc and sheathing of the retinal artery with a dense vitreous haze and a white retinal lesion. Serum anti-toxoplasma antibodies were positive in a latex agglutination assay. Vitrectomy was performed to improve visualization of the retinal lesions and for examination of causative microorganisms. A postoperative fundus examination revealed CRAO with optic disc involvement and multifocal retinitis with perivascular sheathing. Qualitative multiplex polymerase chain reaction detected the Toxoplasma gondii B1 gene in ocular fluid from both the aqueous and vitreous humor. The presumed diagnosis of ocular toxoplasmosis was made and treatment was started with prednisone and acetylspiramycin with subsequent improvement. Two months later, the patient developed active retinochoroiditis in the left eye. After 6 weeks of anti-toxoplasma therapy, the disease involuted. Retinal vascular occlusions and multifocal retinitis with perivascular sheathing are rare in toxoplasmosis. This is the first case report of toxoplasmic CRAO and multifocal retinitis with perivascular sheathing. The diagnosis of ocular toxoplasmosis should be considered in patients with retinal artery occlusions and multifocal retinitis with perivascular sheathing associated with inflammation.Keywords: ocular toxoplasmosis, toxoplasma retinochoroiditis

  15. Long-term trends of global solar ultraviolet-B, ultraviolet-A and total irradiances measured in Japan since 2001

    Science.gov (United States)

    Takeshita, Shu; Sasaki, Masako

    2017-02-01

    Global and diffuse solar ultraviolet-B, ultraviolet-A, and Total irradiances have been measured at Shonan Campus of Tokai University (Kanagawa, Japan, 35°21'N, 139°11'E) since 1990. Analysis of data recorded from Apr. 2001 to Dec. 2015 shows that daily integrated global UV-B irradiance has decreasing in the long-term as -0.381 %/year for the 95 % confidence interval in this period. More detail evaluation is made on the data recorded from Jan. 2009 to Dec. 2015. In this period, an increase trend in global UV-B irradiance was obtained (+0.607 %/year). This result suggests that critical factor on increase in UV-B irradiance is not only ozone amount but also amount of aerosols, sunshine duration and solar cycle.

  16. The urease gene cluster of Vibrio parahaemolyticus does not influence the expression of the thermostable direct hemolysin (TDH) gene or the TDH-related hemolysin gene.

    Science.gov (United States)

    Nakaguchi, Yoshitsugu; Okuda, Jun; Iida, Tetsuya; Nishibuchi, Mitsuaki

    2003-01-01

    In order to investigate why the thermostable direct hemolysin (TDH) and the TDH-related hemolysin (TRH) of Vibrio parahaemolyticus are produced at low levels from urease-positive strains, the effect of the functional urease gene cluster of V. parahaemolyticus on the expression of the tdh and trh genes was examined. Transcriptional lacZ fusions with the tdh1, tdh2, trh1 and trh2 genes representing variants of the tdh and trh genes were integrated into the chromosome of an Escherichia coli strain and a urease-negative V. parahaemolyticus strain. The plasmid-borne urease gene cluster introduced and expressed in these constructs did not affect expression of any of the fusion genes. The amount of TDH produced from a Kanagawa phenomenon-positive V. parahaemolyticus did not change by introduction of the urease gene cluster either. It was concluded therefore that the urease gene cluster is not involved in the regulation of tdh and trh expression.

  17. Identification of tdh-positive Vibrio parahaemolyticus from an outbreak associated with raw oyster consumption in Spain.

    Science.gov (United States)

    Lozano-León, Antonio; Torres, Julio; Osorio, Carlos R; Martínez-Urtaza, Jaime

    2003-09-26

    Between August and September 1999, a total of 64 cases of illness were identified in three episodes of acute gastroenteritis associated with the consumption of live oysters from a typical outdoor street market in Galicia (northwest Spain). Nine case patients were hospitalized and analysis of their stool samples revealed the presence of Vibrio parahaemolyticus. The strains isolated from two stool samples were studied for antibiotic susceptibility, biochemical characteristics and presence of virulence factors. Both isolates were Kanagawa phenomenon positive and produced thermostable direct hemolysin, which is related to pathogenicity in humans. These results show the presence of pathogenic V. parahaemolyticus in mollusks harvested in Europe and reveal the risk of illness associated with their consumption, suggesting the revision of V. parahaemolyticus risk assessment associated with consumption of raw live shellfish.

  18. Urea hydrolysis and suppressed production of thermostable direct hemolysin (TDH) by Vibrio parahaemolyticus associated with presence of TDH-related hemolysin genes.

    Science.gov (United States)

    Okitsu, T; Osawa, R; Pornruangwong, S; Yamai, S

    1997-05-01

    A total of 18 strains of V. parahaemolyticus isolated from patients of past food poisoning cases occurring in Kanagawa Prefecture, Japan, were assayed for presence of the thermostable direct hemolysin (TDH) gene and the TDH-related hemolysin (TRH) genes (trh 1 and trh 2) with specific reference to their ability to hydrolyze urea and TDH production. A polymerase chain reaction assay revealed that all urea-hydrolyzing strains (9 strains) carried either trh 1 gene or trh 2 gene. The strains carrying the trh genes as well as the tdh gene produced TDH less by a factor of 4 to 16 than those carrying only the tdh gene, suggesting the expression of the tdh gene was suppressed by the presence of trh gene through a mechanism yet to be defined.

  19. Evaluation of two assay kits for thermostable direct hemolysin (TDH) as an indicator of TDH-related hemolysin (TRH) produced by Vibrio parahaemolyticus.

    Science.gov (United States)

    Yoh, M; Kawakami, N; Funakoshi, Y; Okada, K; Honda, T

    1995-01-01

    Reversed passive latex agglutination (RPLA) or enzyme-linked immunosorbent assay kits with beads (Bead-ELISA) are commercially available in Japan to detect the thermostable direct hemolysin (TDH) produced by Vibrio parahaemolyticus isolates. We evaluated whether these kits can be used to assay the pathogenic toxin, TDH-related hemolysin (TRH), produced by some so-called Kanagawa phenomenon-negative V. parahaemolyticus strains isolated from patients with diarrhea. Our results showed that the two kits, RPLA and Bead-ELISA, can detect TRH, although they were originally developed for detection of TDH. This may be due to the use of polyclonal anti-TDH antisera that cross react with TRH. Although the sensitivity for TDH detection by RPLA and Bead-ELISA differed tenfold, that for TRH detection was essentially equal. The minimum concentration of TRH required for detection by the two assay kits was about 10 ng/ml.

  20. Adjustment procedure for beam alignment in scanned ion-beam therapy

    Science.gov (United States)

    Saraya, Y.; Takeshita, E.; Furukawa, T.; Hara, Y.; Mizushima, K.; Saotome, N.; Tansho, R.; Shirai, T.; Noda, K.

    2016-09-01

    Control of the beam position for three-dimensional pencil-beam scanning is important because the position accuracy of the beam significantly impacts the alignment of the irradiation field. To suppress this effect, we have developed a simple procedure for beamline tuning. At first, beamline tuning is performed with steering magnets and fluorescent screen monitors to converge the beam's trajectory to a central orbit. Misalignment between the beam's position and the reference axis is checked by using the verification system, which consists of a screen monitor and an acrylic phantom. If the beam position deviates from the reference axis, two pairs of steering magnets, which are placed on downstream of the beam transport line, will be corrected. These adjustments are iterated until the deviations for eleven energies of the beam are within 0.5 mm of the reference axis. To demonstrate the success of our procedure, we used our procedure to perform beam commissioning at the Kanagawa Cancer Center.

  1. Occurrence of Vibrio and other pathogenic bacteria in Mytilus galloprovincialis (mussels) harvested from Adriatic Sea, Italy.

    Science.gov (United States)

    Ripabelli, G; Sammarco, M L; Grasso, G M; Fanelli, I; Caprioli, A; Luzzi, I

    1999-08-01

    Sixty-two samples of Mytilus galloprovincialis (mussels) harvested from approved shellfish waters in the Adriatic Sea were examined for the presence of Vibrio, Salmonella, Campylobacter, and verocytotoxin producing Escherichia coli. Vibrio spp. were isolated from 48.4% of samples; the species most frequently found were V. alginolyticus (32.2%) and V. vulnificus (17.7%), followed by V. cincinnatiensis (3.2%), V. parahaemolyticus (1.6%), V. fluvialis (1.6%) and V. cholerae non-O1 (1.6%). V. parahaemolyticus resulted negative to Kanagawa-phenomenon and to PCR amplification of tdh gene. V. cholerae resulted negative to PCR amplification of sto gene. No Salmonella, Campylobacter, or E. coli verocytotoxin-producing strains were isolated. The results of this study suggest the potential risk of ingesting raw or undercooked mussels due to the frequent presence of potentially pathogenic Vibrio species.

  2. Acoustical Imaging

    CERN Document Server

    Akiyama, Iwaki

    2009-01-01

    The 29th International Symposium on Acoustical Imaging was held in Shonan Village, Kanagawa, Japan, April 15-18, 2007. This interdisciplinary Symposium has been taking place every two years since 1968 and forms a unique forum for advanced research, covering new technologies, developments, methods and theories in all areas of acoustics. In the course of the years the volumes in the Acoustical Imaging Series have developed and become well-known and appreciated reference works. Offering both a broad perspective on the state-of-the-art in the field as well as an in-depth look at its leading edge research, this Volume 29 in the Series contains again an excellent collection of seventy papers presented in nine major categories: Strain Imaging Biological and Medical Applications Acoustic Microscopy Non-Destructive Evaluation and Industrial Applications Components and Systems Geophysics and Underwater Imaging Physics and Mathematics Medical Image Analysis FDTD method and Other Numerical Simulations Audience Researcher...

  3. Cronobacter spp. in commercially available dried food in Japan.

    Science.gov (United States)

    Ogihara, Hirokazu; Kiribe, Nami; Fukuda, Noriko; Furukawa, Soichi; Morinaga, Yasushi; Igimi, Shizunobu

    2014-01-01

    A total of 140 samples of dried food sold in Japan were surveyed and tested for the presence of viable bacteria, distribution of coliform bacteria, and contamination with Cronobacter spp. The samples were purchased from retail stores in Tokyo and Kanagawa Prefecture. Out of the 140 samples tested, viable bacteria were found in 135 samples and coliform bacteria were found in 23 samples. Qualitative and quantitative testing revealed the presence of Cronobacter spp. in 35 (25.0%) and 11 samples (7.9%), respectively. The most commonly found Cronobacter species were C. sakazakii, with the next most common, in order, being C. muytjensii and C. turicensis. The actual numbers of Cronobacter species in the tested dried foods were low, but the widespread contamination particularly in dried herbs and vegetables was confirmed.

  4. On-site field test on groundwater re-flooding (2)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-02-01

    A mini-dome (an underground structure to be closed; ground level: - 50 m to - 82.5 m) situated on a diluvium along the Sagami River, Kanagawa prefecture, Japan, was used to perform an on-site field tests on groundwater re-flooding for 11 months after the mini-dome was filled up with sand, mortar, and fluidized soil consisting of cement and mudwater. The present report includes monitoring data of the environmental groundwater at the surrounding bed rocks and of the groundwater in the deep mudstone beneath the site. Change with time at various test points in water pressure, water temperature, pH, electric conductivity, and the temperature of the wall of the structure making the mini-dome is reported. Furthermore, some isotopic abundance and the monitoring results on chemical analysis were also included. (S. Ohno)

  5. Serologic and molecular characterization of Vibrio parahaemolyticus strains isolated from seawater and fish products of the Gulf of Mexico.

    Science.gov (United States)

    Cabrera-García, María Eugenia; Vázquez-Salinas, Carlos; Quiñones-Ramírez, Elsa Irma

    2004-11-01

    The thermostable direct hemolysin (TDH) and TDH-related hemolysin (TRH) are the main virulence factors of Vibrio parahaemolyticus. We isolated V. parahaemolyticus from seawater, fish, and oysters obtained from the Pueblo Viejo Lagoon in Veracruz, determined the serogroups, phenotypically and genotypically characterized TDH and TRH, and investigated the presence of the toxR gene. A total of 46 V. parahaemolyticus strains were isolated, and all of them amplified the 368-bp toxR gene fragment. The trh gene was not identified in any of the strains; 4 of the 46 strains were Kanagawa phenomenon (KP) positive and amplified the 251-bp tdh gene fragment. The most frequent serogroup was serogroup O3. This is the first report of the presence of KP-positive tdh-positive environmental V. parahaemolyticus strains in Mexico.

  6. Bubble Dynamics and Shock Waves

    CERN Document Server

    2013-01-01

    This volume of the Shock Wave Science and Technology Reference Library is concerned with the interplay between bubble dynamics and shock waves. It is divided into four parts containing twelve chapters written by eminent scientists. Topics discussed include shock wave emission by laser generated bubbles (W Lauterborn, A Vogel), pulsating bubbles near boundaries (DM Leppinen, QX Wang, JR Blake), interaction of shock waves with bubble clouds (CD Ohl, SW Ohl), shock propagation in polydispersed bubbly liquids by model equations (K Ando, T Colonius, CE Brennen. T Yano, T Kanagawa,  M Watanabe, S Fujikawa) and by DNS (G Tryggvason, S Dabiri), shocks in cavitating flows (NA Adams, SJ Schmidt, CF Delale, GH Schnerr, S Pasinlioglu) together with applications involving encapsulated bubble dynamics in imaging (AA Doinikov, A Novell, JM Escoffre, A Bouakaz),  shock wave lithotripsy (P Zhong), sterilization of ships’ ballast water (A Abe, H Mimura) and bubbly flow model of volcano eruptions ((VK Kedrinskii, K Takayama...

  7. Property of Fluctuations of Sales Quantities by Product Category in Convenience Stores.

    Directory of Open Access Journals (Sweden)

    Gaku Fukunaga

    Full Text Available The ability to ascertain the extent of product sale fluctuations for each store and locality is indispensable to inventory management. This study analyzed POS data from 158 convenience stores in Kawasaki City, Kanagawa Prefecture, Japan and found a power scaling law between the mean and standard deviation of product sales quantities for several product categories. For the statistical domains of low sales quantities, the power index was 1/2; for large sales quantities, the power index was 1, so called Taylor's law holds. The value of sales quantities with changing power indixes differed according to product category. We derived a Poissonian compound distribution model taking into account fluctuations in customer numbers to show that the scaling law could be explained theoretically for most of items. We also examined why the scaling law did not hold in some exceptional cases.

  8. [Distribution of Clostridium tetani in topsoil from Sagamihara, central Japan].

    Science.gov (United States)

    Haneda, Jun; Shiobara, Yasumasa; Inui, Masami; Sekiguchi, Tomoko; Sato, Yoshinori; Takayama, Yoko; Kikuno, Ritsuko; Okuda, Shunji; Inoue, Matsuhisa; Sasahara, Takeshi

    2006-11-01

    Despite reports of Clostridium tetani being isolated from soil in Kanazawa, Okinawa, and Tokyo, Japan, little has been studied about C. tetani distribution in other regions. We studied C. tetani in topsoil samples collected from private gardens, public road shoulders, a university campus, mountains, and fields in Sagamihara. C. tetani occurred in 8 of 35 soil samples (22.9%) and tetanus toxin in 7 of the 8 C. tetani-positive samples (87.5%). Contamination was clearly higher in soils from mountains near Tsukui-gun (Kanagawa Prefecture), Minamitsuru-gun, and Uenohara and Koshu cities (Yamanashi Prefecture) than in other regions. These findings suggest that tetanus toxin-producing strains of C. tetani tend to inhabit the topsoil of western Sagaminaha region, as a geographical feature.

  9. Demonstration and characterization of simultaneous production of a thermostable direct hemolysin (TDH/I) and a TDH-related hemolysin (TRHx) by a clinically isolated Vibrio parahaemolyticus strain, TH3766.

    Science.gov (United States)

    Xu, M; Iida, T; Yamamoto, K; Takarada, Y; Miwatani, T; Honda, T

    1994-01-01

    Simultaneous production of a thermostable direct hemolysin (TDH)-like toxin (TDHx) and a TDH-related hemolysin (TRH)-like toxin (TRHx) by a clinical isolate (strain TH3766) of Kanagawa phenomenon-positive Vibrio parahaemolyticus was demonstrated and characterized. The two hemolysins were differentially purified by column chromatography on hydroxyapatite and immunoaffinity columns. The molecular weight of the two hemolysins were estimated to be 23,000 by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (PAGE). The purified TDHx was indistinguishable from the previously reported TDH/I (from strain TH012) but was different from the authentic TDH of a Kanagawa phenomenon-positive strain (T4750) physicochemically. The mobility of TRHx in nondenaturing PAGE differed from all the known TDHs and TRHs. The genes (tdhX and trhX) coding for TDHx and TRHx were cloned and sequenced. Homologies of nucleotide sequences of the coding regions between tdhX and tdhA (a gene for the authentic TDH) and between trhX and trh (a gene for the authentic TRH) were 98.1 and 99.1%, respectively, and homology between tdhX and trhX was 68.1%. At the amino acid level, TdhX was completely identical to TDH/I, although two base differences were found in the nucleotide sequences between tdhX and tdh/I. Two amino acid differences were observed between TrhX and Trh. Thus, these findings suggest that the TH3766 strain produces two types of hemolysins simultaneously. This is the first evidence that a strain of V. parahaemolyticus produces two types of toxins of the TDH-TRH family at the same time.

  10. Railway suicide attempts are associated with amount of sunlight in recent days.

    Science.gov (United States)

    Kadotani, Hiroshi; Nagai, Yumiko; Sozu, Takashi

    2014-01-01

    To assess the relationship between hours of sunlight and railway suicide attempts, 3-7 days before these attempts. All railway suicide attempts causing railway suspensions or delays of 30 min or more between 2002 and 2006. We used a linear probability model to assess this relationship. This study was conducted at Tokyo, Kanagawa, and Osaka prefectures in Japan. Data were collected from the railway delay incident database of the Japanese Railway Technical Research Institute and public weather database of the Japan Meteorological Agency. About 971 railway suicides attempts occurred between 2002 and 2006 in Tokyo, Kanagawa, and Osaka. Less sunlight in the 7 days leading up to the railway suicide attempts was associated with a higher proportion of attempts (p=0.0243). Sunlight over the 3 days before an attempt had a similar trend (p=0.0888). No difference was found in sunlight hours between the days with (median: 5.6 [IQR: 1.1-8.8]) and without (median: 5.7 [IQR: 1.0-8.9]) railway suicide attempts in the evening. Finally, there was no apparent correlation between the railway suicide attempts and the monthly average sunlight hours of the attempted month or those of a month before. Railway suicides were not the main suicidal methods in Japan, We observed an increased proportion of railway suicide attempts after several days without sunlight. Light exposure (blue light or bright white light) in trains may be useful in reducing railway suicides, especially when consecutive days without sunshine are forecasted. © 2013 Elsevier B.V. All rights reserved.

  11. Effects of vegetarian diets on blood pressure

    Directory of Open Access Journals (Sweden)

    Yokoyama Y

    2016-04-01

    Full Text Available Yoko Yokoyama,1,2 Kazuo Tsubota,2,3 Mitsuhiro Watanabe1,2,4,5 1Graduate School of Media and Governance, Keio University, Fujisawa, Kanagawa, 2Health Science Laboratory, 3Department of Ophthalmology, 4Department of Internal Medicine, Keio University School of Medicine, Tokyo, 5Faculty of Environment and Information Studies, Keio University, Fujisawa, Kanagawa, Japan Abstract: Hypertension is a major independent risk factor for coronary artery diseases, and the prevalence of hypertension is continuously increasing. Diet is an important factor that can be modified to prevent hypertension. According to the US Department of Health and Human Services, dietary patterns are defined as the quantities, proportions, and variety or combinations of different foods and beverages in diets and the frequency with which they are habitually consumed. In this review, the vegetarian dietary pattern is introduced with a focus on the effect on blood pressure (BP. Although the available evidence is limited, according to a previous meta-analysis of controlled trials, vegetarian dietary patterns significantly reduced systolic and diastolic BPs. One of the common features of a vegetarian diet is weight loss, which might, at least partially, explain the effect on BP. Other possible factors such as sodium, potassium, protein, amino acids, vitamin B-12, antioxidants, fiber, and the microbiome are introduced as possible mechanisms. Further studies are needed with non-Western populations to determine the most effective vegetarian dietary pattern and to explore the exact mechanisms by which these dietary patterns affect BP. Keywords: vegetarian diet, plant-based diet, blood pressure, hypertension, meta-analysis

  12. Self-interest and Social Needs Motivated Scientific Breakthroughs:How Isamu Akasaki Won the 2014 Nobel Prize in Physics%个人兴趣与社会需求共同驱动型科技突破--赤崎勇何以能获得2014年诺贝尔物理学奖

    Institute of Scientific and Technical Information of China (English)

    周程

    2014-01-01

    2014年,日本科学家赤崎勇和天野浩以及一名日裔美籍学者中村修二共同获得了诺贝尔物理学奖。赤崎勇是天野浩的指导教师,也是蓝光LED研究领域的开创者,具有较强的代表性。这篇文章考察了赤崎勇的早期学习与研究经历,梳理了赤崎勇步入化合物半导体结晶研究领域、制备高质量氮化镓单晶体取得突破、成功研制高效蓝色LED等事件的来龙去脉,并分析了赤崎勇取得诺贝尔奖级重大科技突破的主要因素,讨论了重大科技突破与科学家个人兴趣及社会需求的关系。深入剖析赤崎勇的研究历程,有助于为我国的科技政策制定与优化提供新思路。%In 2014, Japanese scientist Isamu Akasaki and Hiroshi Amano won the Nobel prize in physics together with Japanese American scientist ShujiNakamur. Isamu Akasaki,Hiroshi Amano's tutor as well as the pioneer on the blue LED research, is the most representative one. In this article,the author introduced Isamu Akasaki's study and research in his early years, reviewed how he went into thesemiconductive chemical compound research field, In this field, he made the gallium nitride monocrystal preparation, and developed the hi-lite blue LED. The article analyzed the main factors of winning the Nobel prize-class scientific breakthroughs, and discussed the relationship among great scientific breakthroughs, scientist's self-interest as well as social needs. Analyzing Isamu Akasaki's research process is helpful to providing a new way for China's scientific and technological policies making and optimization.

  13. Relationship between performance test and body composition/physical strength characteristic in sprint canoe and kayak paddlers

    Directory of Open Access Journals (Sweden)

    Hamano S

    2015-06-01

    Full Text Available Saki Hamano,1 Eisuke Ochi,2 Yosuke Tsuchiya,3 Erina Muramatsu,4 Kazuhiro Suzukawa,5 Shoji Igawa1 1Department of Sports Nutrition, Nippon Sport Science University, Yokohama, Kanagawa, 2Graduate School of Education, Okayama University, Okayama, 3Laboratory of Health and Sports Sciences, Meiji Gakuin University, Yokohama, Kanagawa, 4Department of Natural Sciences, Nippon Sport Science University, Setagaya, Tokyo, .5Laboratory of Preventive Medicine and Public Health, Nippon Sport Science University, Setagaya, Tokyo, Japan Objective: Canoe sprint is divided into canoe and kayak. The difference between the two competitions is in physical performance. The aim of the present study was to compare and investigate the relationship between physical characteristics and fitness between the two canoe sprint competitors. Methods: Subjects were 11 canoe paddlers (C and 12 kayak paddlers (K. They underwent anthropometric characteristics, body composition and fitness tests, and 120 s all-out tests using a canoe and kayak ergometer. The unpaired t-test was used to test for significant differences between disciplines, while Pearson's correlation coefficient was used to examine the association between each measurement item and the performance test. Results: The age, height, body mass, body mass index, and total body fat were, C: 20.6±0.9 yr, 172.8±5.2 cm, 70.8±7.8 kg, 23.7±1.9, 14.4%±3.5%; and K: 19.7±1.2 yr, 172.8±5.3 cm, 69.5±7.8 kg, 23.2±2.1, 12.1%±3.6%, respectively. No significant differences were seen in any of the items for physical characteristics or fitness between C and K. A correlation analysis of performance tests and each measurement item revealed a positive correlation with low-speed isokinetic knee extension and flexion strength for C only (extension: r=0.761; flexion: r=0.784; P<0.01. In addition, performance tests were positively correlated with the circumference of arm (upper arm: r=0.876; forearm: r=0.820; P<0.01 and lower limb (thigh: r

  14. Molecular diagnostics of a single drug-resistant multiple myeloma case using targeted next-generation sequencing

    Directory of Open Access Journals (Sweden)

    Ikeda H

    2015-10-01

    Full Text Available Hiroshi Ikeda,1 Kazuya Ishiguro,1 Tetsuyuki Igarashi,1 Yuka Aoki,1 Toshiaki Hayashi,1 Tadao Ishida,1 Yasushi Sasaki,1,2 Takashi Tokino,2 Yasuhisa Shinomura1 1Department of Gastroenterology, Rheumatology and Clinical Immunology, 2Medical Genome Sciences, Research Institute for Frontier Medicine, Sapporo Medical University, Sapporo, Japan Abstract: A 69-year-old man was diagnosed with IgG λ-type multiple myeloma (MM, Stage II in October 2010. He was treated with one cycle of high-dose dexamethasone. After three cycles of bortezomib, the patient exhibited slow elevations in the free light-chain levels and developed a significant new increase of serum M protein. Bone marrow cytogenetic analysis revealed a complex karyotype characteristic of malignant plasma cells. To better understand the molecular pathogenesis of this patient, we sequenced for mutations in the entire coding regions of 409 cancer-related genes using a semiconductor-based sequencing platform. Sequencing analysis revealed eight nonsynonymous somatic mutations in addition to several copy number variants, including CCND1 and RB1. These alterations may play roles in the pathobiology of this disease. This targeted next-generation sequencing can allow for the prediction of drug resistance and facilitate improvements in the treatment of MM patients. Keywords: multiple myeloma, drug resistance, genome-wide sequencing, semiconductor sequencer, target therapy

  15. Low levels of plasma endothelin-1 in patients with retinitis pigmentosa

    Directory of Open Access Journals (Sweden)

    Hiroshi Ohguro

    2010-06-01

    Full Text Available Hiroshi Ohguro1, Yukihiko Mashima2, Mitsuru Nakazawa31Department of Ophthalmology, Sapporo Medical University School of Medicine, 2Department of Ophthalmology, Keio University School of Medicine, 3Department of Ophthalmology, Hirosaki University School of Medicine, JapanPurpose: The aim of this study was to elucidate the role of endothelin-1 (ET-1 in the pathophysiology of retinitis pigmentosa (RP.Methods: Plasma ET-1 levels and ophthalmic features in 50 RP patients were compared with those in 20 healthy-eye control subjects. Plasma ET-1 concentrations were determined using a commercially available enzyme-linked immunosorbent assay kit.Results: Mean plasma ET-1 levels of RP patients (1.88 ± 0.56 pg/mL were significantly lower than those of control subjects (2.30 ± 0.30 pg/mL, Mann-Whitney’s U test; P < 0.01. However, ET-1 concentrations varied markedly in each patient. Among RP patients, a significant correlation of ET-1 concentrations was not observed in terms of its hereditary forms or other clinical factors.Conclusion: ET-1 may be important in the pathogenesis of RP, and measurement of its plasma concentrations may also contribute to additional insights into the retinal hemodynamics of RP.Keywords: endothelin-1, retinitis pigmentosa, retinal hemodynamics

  16. WHO still reeling from racism charges.

    Science.gov (United States)

    1995-06-01

    The World Health Organization (WHO) is not as prestigious as it used to be. It operates on a relatively small annual budget of $1.8 billion, the WHO 1995 audit suggested irregularities in the way contracts were awarded and criticized a lack of control over funds at the WHO's African headquarters in the Congo, and its director, Hiroshi Nakajima, has been accused of being a racist against Africans. Nakajima complained during a January 1995 WHO board meeting that some African members had poor English skills. Delegates from several African nations to the annual World Health Assembly, which began in Geneva on May 1, subsequently raised the issue and called for the Japanese director to resign. The release of the recent WHO health report, "Bridging the Gaps," was an attempt by the organization to regain some its international respect, but little new was reported. Basic messages were that poverty is the most important cause of ill health, 60% of all new HIV infections occur among people aged 15-24 in many countries, 50% of people with HIV globally are younger than 25 years old, 60% of infections in women occur by age 20, and life expectancy is increasing in all countries except Cote d'Ivoire, Central African Republic, Congo, Uganda, and Zambia, all countries hard-hit by HIV/AIDS. For now, Nakajima has retained his position, although British and US donors stress that they will keep closer watch over the organization and that reforms must be made.

  17. PREFACE: IUMRS-ICA 2008 Symposium, Sessions 'X. Applications of Synchrotron Radiation and Neutron Beam to Soft Matter Science' and 'Y. Frontier of Polymeric Nano-Soft-Materials - Precision Polymer Synthesis, Self-assembling and Their Functionalization'

    Science.gov (United States)

    Takahara, Atsushi; Kawahara, Seiichi

    2009-09-01

    Tashiro (Toyota Technological Institute) Professor Kazuo Sakurai(Kitakyushu University) Professor Keiji Tanaka (Kyushu University) Dr Sono Sasaki (JASRI/Spring-8) Professor Naoya Torikai (KENS) Professor Moonhor Ree (POSTECH) Professor Kookheon Char (Seoul National University) Professor Charles C Han (CAS) Professor Atsushi Takahara(Kyushu University) Frontier of Polymeric Nano-Soft-Materials, Precision Polymer Synthesis, Self-assembling and Their Functionalization (Symposium Y of IUMRS-ICA2008) Seiichi Kawahara, Rong-Ming Ho, Hiroshi Jinnai, Masami Kamigaito, Takashi Miyata, Hiroshi Morita, Hideyuki Otsuka, Daewon Sohn, Keiji Tanaka It is our great pleasure and honor to publish peer-reviewed papers, presented in Symposium Y 'Frontier of Polymeric Nano-Soft-Materials Precision Polymer Synthesis, Self-assembling and Their Functionalization' at the International Union of Materials Research Societies International Conference in Asia 2008 (IUMRS-ICA2008), which was held on 9-13 December 2008, at Nagoya Congress Center, Nagoya, Japan. 'Polymeric nano-soft-materials' are novel outcomes based on a recent innovative evolution in polymer science, i.e. precision polymer synthesis, self-assembling and functionalization of multi-component systems. The materials are expected to exhibit specific functions and unique properties due to their hierarchic morphologies brought either by naturally-generated ordering or by artificial manipulation of the systems, e.g., crystallization and phase-separation. The emerging precision synthesis has brought out new types of polymers with well-controlled primary structures. Furthermore, the surface and interface of the material are recognized to play an important role in the outstanding mechanical, electrical and optical properties, which are required for medical and engineering applications. In order to understand structure-property relationships in the nano-soft-materials, it is indispensable to develop novel characterization techniques. Symposium Y

  18. Non-Descemet’s stripping automated endothelial keratoplasty for bullous keratopathy secondary to iridoschisis

    Directory of Open Access Journals (Sweden)

    Minezaki T

    2013-07-01

    Full Text Available Teruumi Minezaki, Takaaki Hattori, Hayate Nakagawa, Shigeto Kumakura, Hiroshi GotoDepartment of Ophthalmology, Tokyo Medical University, Shinjukuku, Tokyo, JapanPurpose: To report a case of bullous keratopathy secondary to iridoschisis treated by non-Descemet's stripping automated endothelial keratoplasty (nDSAEK.Case report: A 79-year-old woman was referred to our hospital with loss of vision in the left eye. Slit lamp examination of her left eye showed a shallow anterior chamber with cataract and schisis in the inferior quadrant of iris stroma. Bullous keratopathy secondary to iridoschisis was diagnosed. Cataract surgery with iridectomy succeeded to deepen the anterior chamber and remove the floating iris leaf, although corneal edema remained. Four days later, nDSAEK was performed, which resolved corneal edema and restored visual acuity.Conclusion: The two-step surgery of cataract surgery plus iridectomy followed by nDSAEK may be an effective strategy for treating bullous keratopathy secondary to iridoschisis.Keywords: iridoschisis, bullous keratopathy, non-Descemet's stripping automated endothelial keratoplasty

  19. [The history and library the Goda family of medical doctors].

    Science.gov (United States)

    Machi, Senjuro; Kosoto, Hiroshi; Amano, Yosuke; Hanawa, Toshihiko

    2005-12-01

    The Goda family discussed in this paper is a family lineage that served as the official physicians to the Sakakibara family that ruled Takada han in Echigo province from the middle of the Edo period. Last year old medical materials and writings that had been transmitted by the family were transferred to the Oriental Medicine Research Center of the Kitasato Institute. The authors have had the opportunity to study the family genealogy and collate these archives. The Goda family has continued through eight generations. These are, respectively- (1) the founder Heizo; (2) Chuzo; (3) Shojun; (4) Yoan; (5) Yoshinobu; (6) Hitoshi; (7) Hiroshi; and (8) the present head, Takashi. We have identified two lines of physicians in collateral families (from Susumu and Akira, both sons of Yoshinobu). The archive as received is comprised of 138 separate items from a total of 450 volumes. Of these, medical works constitute 102 items in 283 volumes. The library provides valuable material which sheds light on the standard of medicine in the Takada area of Echigo from the late Edo through the Meiji periods.

  20. Conference Committees: Conference Committees

    Science.gov (United States)

    2009-09-01

    International Programm Committee (IPC) Harald Ade NCSU Sadao Aoki University Tsukuba David Attwood Lawrence Berkeley National Laboratory/CXRO Christian David Paul Scherrer Institut Peter Fischer Lawrence Berkeley National Laboratory Adam Hitchcock McMaster University Chris Jacobsen SUNY, Stony Brook Denis Joyeux Lab Charles Fabry de l'Institut d'Optique Yasushi Kagoshima University of Hyogo Hiroshi Kihara Kansai Medical University Janos Kirz SUNY Stony Brook Maya Kiskinova ELETTRA Ian McNulty Argonne National Lab/APS Alan Michette Kings College London Graeme Morrison Kings College London Keith Nugent University of Melbourne Zhu Peiping BSRF Institute of High Energy Physics Francois Polack Soleil Christoph Quitmann Paul Scherrer Institut Günther Schmahl University Göttingen Gerd Schneider Bessy Hyun-Joon Shin Pohang Accelerator Lab Jean Susini ESRF Mau-Tsu Tang NSRRC Tony Warwick Lawrence Berkeley Lab/ALS Local Organizing Committee Christoph Quitmann Chair, Scientific Program Charlotte Heer Secretary Christian David Scientific Program Frithjof Nolting Scientific Program Franz Pfeiffer Scientific Program Marco Stampanoni Scientific Program Robert Rudolph Sponsoring, Financials Alfred Waser Industry Exhibition Robert Keller Public Relation Markus Knecht Computing and WWW Annick Cavedon Proceedings and Excursions and Accompanying Persons Program Margrit Eichler Excursions and Accompanying Persons Program Kathy Eikenberry Excursions and Accompanying Persons Program Marlies Locher Excursions and Accompanying Persons Program

  1. Imagine math 3 between culture and mathematics

    CERN Document Server

    2015-01-01

    Imagine mathematics, imagine with the help of mathematics, imagine new worlds, new geometries, new forms. This volume in the series “Imagine Math” casts light on what is new and interesting in the relationships between mathematics, imagination, and culture. The book opens by examining the connections between modern and contemporary art and mathematics, including Linda D. Henderson’s contribution. Several further papers are devoted to mathematical models and their influence on modern and contemporary art, including the work of Henry Moore and Hiroshi Sugimoto. Among the many other interesting contributions are an homage to Benoît Mandelbrot with reference to the exhibition held in New York in 2013 and the thoughts of Jean-Pierre Bourguignon on the art and math exhibition at the Fondation Cartier in Paris. An interesting part is dedicated to the connections between math, computer science and theatre with the papers by C. Bardainne and A. Mondot.  The topics are treated in a way that is rigorous but capt...

  2. Descemet-stripping automated endothelial keratoplasty for vitrectomized cases with traumatic aniridia and aphakic bullous keratopathy

    Directory of Open Access Journals (Sweden)

    Eguchi H

    2012-09-01

    Full Text Available Hiroshi Eguchi, Tatsuro Miyamoto, Fumika Hotta, Machiko Tomida, Masayuki Inoue, Yoshinori MitamuraDepartment of Ophthalmology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, JapanAbstract: The surgical indication for Descemet-stripping automated endothelial keratoplasty (DSAEK is largely limited to phakic or pseudophakic cases of endothelial dysfunction with normal pupils, because the endothelial lenticule is generally attached to the recipient cornea by use of gas tamponade into the anterior chamber. Although it may be desirable for vitrectomized cases with aniridia and aphakic bullous keratopathy without capsule support to undergo DSAEK, one of the major problems is lenticule detachment during surgery or in the postoperative period. To perform DSAEK in such cases, special surgical techniques are needed in order to facilitate adhesion of the lenticule. Herein, we describe a suture technique for attaching the endothelial lenticule in DSAEK for aniridic and aphakic cases that have undergone vitrectomy for traumatic vitreoretinal disease.Keywords: traumatic aniridia, aphakic bullous keratopathy, Descemet-stripping automated endothelial keratoplasty, vitrectomy

  3. Report on survey in fiscal 2000 on the survey on succession of history of industrial technologies. Survey edition of originality and creativity of industrial machine technologies in Japan; 2000 nendo sangyo gijutsu rekishi keisho chsao hokokusho. Kokunai sangyo kikai gijutsu no dokusosei to sozosei noc hosahen

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-03-01

    In order to clarify the innovation process of industrial technologies in Japan and the originality and creativity seen in the process, the case history has been introduced in relation with the researchers, engineers, and business proprietors having contributed to the innovation, and their work records. With regard to machine tools, detailed introductions were given to 'Toshisuke Takeo' who had the technological concept learned in the United States, and devoted himself in building modern machine tools, an American, 'Willian R. Gorham', who had worked actively in Japan even during the war, 'Hiroshi Hanaoka' who had made a machining center for the first time in Japan, and 'Shinkichi Nagaoka' a developer of the non-circular flat bearing. In the railway area, 'Richard Francis Trevithick' and 'Francis Henry Trevithick' , leaders of the rolling stock manufacturing technologies, 'Yasujiro Shima' who had contributed to building the foundation of the Japan's rolling stock technologies, 'Kiichi Asakura' who had contributed to establishment of the Japan's rolling stock technologies and industry standardization, and 'Hideo Shima' who had borne fruit of systematization of the Japan's railway technologies by building the Shinkansen were introduced in detail. (NEDO)

  4. Irrigation dynamic pressure-assisted hydrodissection during cataract surgery

    Directory of Open Access Journals (Sweden)

    Masuda Y

    2017-02-01

    Full Text Available Yoichiro Masuda,1 Hisaharu Iwaki,2 Noriko Kato,1 Genichiro Takahashi,1 Kotaro Oki,3 Hiroshi Tsuneoka4 1Department of Ophthalmology, The Jikei University, Katsushika Medical Center, 2Iwaki Eye Clinic, 3Oki Eye Surgery Center, 4Department of Ophthalmology, The Jikei University, School of Medicine, Tokyo, Japan Abstract: The irrigation dynamic pressure-assisted hydrodissection technique (irrigation-hydro [iH] does not require performing manual hydrodissection using a syringe and cannula to achieve cortical-capsular cleavage during cataract surgery. Since the iH technique uses the phaco tip to intentionally vacuum the intraocular fluid in order to induce the irrigation dynamic pressure for cortical-capsular cleavage, there is a reduction in the intraocular pressure (IOP from the bottle-height-dependent hydrostatic pressure. Thus, since the peak irrigation pressure derived from the phaco tip sleeve will be limited by the height of the irrigation fluid bottle, this is advantageous in helping to avoid excessively high IOP during cortical-capsular hydrodissection. Using this technique, we were able to effectively perform phacoemulsification without complications in 607 of 609 cataract eyes. Our findings show that utilization of the iH technique would be of benefit to patients, as it prevents high-pressure hydrodissection-related complications, such as capsular block syndrome and tears in the anterior hyaloid membrane during cataract surgery. Keywords: cataract surgery, hydrodissection, irrigation pressure, hydrodissection-related complication, capsular block syndrome, anterior hyaloid membrane tear, FLACS

  5. Astrobiology: The Search for Life in the Universe

    Science.gov (United States)

    Pacchioli, David

    2003-01-01

    Each of the 11 lead members of NASA's Astrobiology Institute has a specific mission. According to Hiroshi Ohmoto, director of Penn State s Astrobiology Research Center, Here we are mainly concerned with the origin of life and the evolution and extinction of important organisms. These include bacteria that live on methane, cyanobacteria (the inventors of photosynthesis), eukaryotes (a big category, covering anything with a nucleus, from single-celled organisms to humans), land-dwelling organisms, and early animals. Penn State astrobiologists are studying the environment before there was life on Earth, the origin of oxygen in the atmosphere, the chemical and thermal structures of oceans, and the role of metals in the evolution of life. Overall, they want to understand the connection between changes in environment and changes in life forms in the early Earth. PSARC offers research assistantships for graduate and undergraduate students, fellowships for graduate students and post-doctoral fellows, and an undergraduate minor in astrobiology. The minor covers 18 credits in earth sciences, geochemistry, geophysics, astronomy, biology, biochemistry, meteorology, and microbiology. The goal, says Ohmoto, is to teach students to critically evaluate claims related to this field that they encounter well after their college education has ended. Under a scanning electron microscope, Martian meteorite ALH84001 yields tube-like structures that look a lot like remnants of Earthly bacteria except smaller by a factor of ten.

  6. Astrobiology: The Search for Life in the Universe

    Science.gov (United States)

    Pacchioli, David

    2003-01-01

    Each of the 11 lead members of NASA's Astrobiology Institute has a specific mission. According to Hiroshi Ohmoto, director of Penn State s Astrobiology Research Center, Here we are mainly concerned with the origin of life and the evolution and extinction of important organisms. These include bacteria that live on methane, cyanobacteria (the inventors of photosynthesis), eukaryotes (a big category, covering anything with a nucleus, from single-celled organisms to humans), land-dwelling organisms, and early animals. Penn State astrobiologists are studying the environment before there was life on Earth, the origin of oxygen in the atmosphere, the chemical and thermal structures of oceans, and the role of metals in the evolution of life. Overall, they want to understand the connection between changes in environment and changes in life forms in the early Earth. PSARC offers research assistantships for graduate and undergraduate students, fellowships for graduate students and post-doctoral fellows, and an undergraduate minor in astrobiology. The minor covers 18 credits in earth sciences, geochemistry, geophysics, astronomy, biology, biochemistry, meteorology, and microbiology. The goal, says Ohmoto, is to teach students to critically evaluate claims related to this field that they encounter well after their college education has ended. Under a scanning electron microscope, Martian meteorite ALH84001 yields tube-like structures that look a lot like remnants of Earthly bacteria except smaller by a factor of ten.

  7. The effects of electroconvulsive therapy on tardive dystonia or dyskinesia induced by psychotropic medication: a retrospective study

    Directory of Open Access Journals (Sweden)

    Yasui-Furukori N

    2014-07-01

    Full Text Available Norio Yasui-Furukori,1 Atsuhiro Kikuchi,1 Hiroshi Katagai,1,2 Sunao Kaneko11Department of Neuropsychiatry, Hirosaki University School of Medicine, 2Department of Neuropsychiatry, Hirosaki-Aiseikai Hospital, Hirosaki, JapanBackground: Tardive dystonia and dyskinesia are potentially irreversible neurological syndromes. Successful electroconvulsive treatment (ECT has been reported by multiple sources; however, the existing retrospective reviews and open prospective trials provide little information on the response rate.Methods: Eighteen consecutive patients with tardive dystonia or dyskinesia received a standard course of ECT to treat abnormal movement. The severity of the tardive dystonia and dyskinesia was evaluated using the Abnormal Involuntary Movement Scale (AIMS before and after the course of ECT. The patients who displayed a greater than 50% improvement in the AIMS score were classified as the responders.Results: The mean AIMS score decreased from 19.1±4.7 to 9.6±4.2. There were seven responders among the 18 patients, which yielded a 39% response rate. Conclusion: ECT has a moderate but significant effect on tardive dystonia and dyskinesia. Keywords: tardive dystonia, tardive diskinesia, ECT, medication

  8. Report on survey in fiscal 2000 on the survey on succession of history of industrial technologies. Survey edition of originality and creativity of electric and electronic technologies in Japan; 2000 nendo sangyo gijutsu rekishi keisho chosa hokokusho. Kokunai sangyo no denki denshi gijutsu no dokusosei to sozosei no chosahen

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-03-01

    In order to clarify the innovation process of industrial technologies in Japan and the originality and creativity seen in that process to serve for the future development, hearing surveys have been performed. The persons being the hearing objects are Mr. Koichi Oshima who has researched the series capacitors for power transmission cables, Mr. Makoto Osatake who has researched the distortion in frequency modulation, and Mr. Hisao Oka who has researched the destruction phenomena in rectifier elements of power semiconductors. Mr. Hiroshi Inose and Mr. Toichiro Koike who have accepted the hearing survey were represented by the mourning statements due to their sudden death. The items of the questions in the hearing survey included: their home background, why have they studied electricity area specially?, determination criteria when they were forced to make a serious selection and the results thereof, examples of successes and failures and the age background, breakthrough points in the success cases, what they want to convey to future generations from their achievements, what they wished if they have done, methods of conveying the technologies, persons whom they respect as their teachers, existence of persons who have given them protection, sources of passion and motivation that supported the research life, and the principles toward the research. (NEDO)

  9. Bifocal contact lenses: History, types, characteristics, and actual state and problems

    Directory of Open Access Journals (Sweden)

    Hiroshi Toshida

    2008-07-01

    Full Text Available Hiroshi Toshida, Kozo Takahashi, Kazushige Sado, Atsushi Kanai, Akira MurakamiDepartment of Ophthalmology, Juntendo University School of Medicine, Tokyo, JapanAbstract: Since people who wear contact lenses (CL often continue using CL even when they develop presbyopia, there are growing expectations for bifocal CL. To understand actual state and problems, history, types, and their characteristics are summarized in this review. Bifocal CL have a long history over 70 years. Recently, bifocal CL have achieved remarkable progress. However, there still is an impression that prescription of bifocal CL is not easy. It should also be remembered that bifocal CL have limits, including limited addition for near vision, as well as the effects of aging and eye diseases in the aged, such as dry eye, astigmatism, cataract, etc. Analysis of the long-term users of bifocal CL among our patients has revealed the disappearance of bifocal CL that achieved unsatisfactory vision and poor contrast compared with those provided by other types of CL. Changing the prescription up to 3 times for lenses of the same brand may be appropriate. Lenses that provide poor contrast sensitivity, suffer from glare, or give unsatisfactory vision have been weeded out. The repeated replacement of products due to the emergence of improved or new products will be guessed.Keywords: bifocal contact lens, presbyopia, accommodation

  10. “When I Grow Up, I Will be an Artist.” Japanese Avant-garde’s Experimental Sandpit

    Directory of Open Access Journals (Sweden)

    klara / HRVATIN

    2017-01-01

    Full Text Available Sōgetsu Art Center, one of the most important venues for the avant-garde in 1960s Japan, could be defined as an artistic “experimental sandpit”. Its activities brought new musical expressions to the world of Japanese art, and lead to the independent film production. Japanese artists could play in this sandpit with a group of interdisciplinary peers and thus search for their most suitable artistic styles. Good examples are film director Hiroshi Teshigahara (1927–2001, playwright Kōbō Abe (1924–1993 and musician Tōru Takemitsu (1930–1996. The article gives an insight into the artistic associations and events, which took place under the roof of the Sōgetsu Art Center in the period from September 1958 to March 1971. The emphasis will be put on the main associations; activities related to the fields of jazz music, contemporary music, experimental film and animation. We will look for the common ground among these, and note the innovations which were brought about by the main participants at the Center in the fields of music and film.

  11. Increase of acceptability period of Musca domestic l., 1758 (diptera: muscidae) pupae, irradiated by gamma radiation as host of the pupal parasitoid Spalangia endius, Walker, 1839 (hymenoptera: pteromalidae)

    Energy Technology Data Exchange (ETDEWEB)

    Itepan, Natanael M., E-mail: nmitepan@ifsp.edu.br [Instituto Federal de Sao Paulo (IFSP), Piracicaba, SP (Brazil); Itepan, Sara E.D.Z., E-mail: sarazenitepan@ig.com.br [Universidade de Sao Paulo (FFCLRP/USP), Ribeirao Preto, SP (Brazil). Faculdade de Filosofia Ciencias e Letras; Arthur, Valter, E-mail: arthur@cena.usp.br [Centro de Energia Nuclear na Agricultura (CENA/USP), Piracicaba, SP (Brazil)

    2013-07-01

    This experiment was carried out in Biological Control of Domestic Fly 'Eduardo Hiroshi Mizumoto' Laboratory at Entomology and Acarology Department (LEA/ESALQ/USP) and in Food Irradiation and Radioentomology Laboratory (LIARE/CENA/USP). The gamma radiation source used was a Co-60 irradiator model Gammabeam-650 of the Atomic Energy of Canada Ltd. whose activity in the beginning of the experiments was 9.8x10{sup 13} Bq. (2,644 Ci). The lots of pupae of Musca domestic L., 1758 and the parasitoid Spalangia endius Walker, 1839 had been kept in acclimatized room with 25 ± 2 deg C of temperature and 70 ± 5% of relative humidity. This experiment was designed to investigate if the non-viabilization M. domestic pupae, using gamma radiation, could build up the acceptability period as host of the pupal parasitoid S. endius. At these age intervals, the dose to prevent adult emergence was 25, 220, 360 and 520 Gy respectively. The 1, 2, 3 and 4 days old pupae were irradiated (dose rate: 1,510 Gy/hr) and exposed to the parasitoid S. endius at a proportion of one female parasitoid to five housefly pupae, during different periods after the irradiation. The results allow us to conclude that irradiation increase the acceptability period of the housefly pupae by the parasitoid. The best age to irradiate the housefly pupae was one day. (author)

  12. Fiscal 2001 photovoltaic power generation field test project (Locations of systems installed in fiscal 1998-2000 at public facilities and industries); 2001 nendo taiyoko field test jigyo (Kokyo shisetsuyou sangyo tou you 1998 - 2000 nendo secchisha)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-05-01

    The test was conducted for systems installed at General Health and Welfare Center, Munakata City, Fukuoka Prefecture; Comprehensive Traffic Center, Yamaguchi Prefecture; Primary schools, Sendai City, Miyagi Prefecture; Sakuragi Children's House, Shizuoka Prefecture; Midorigaoka Primary School, Hyogo Prefecture; Heath Center, Minamata City, Kumamoto Prefecture; Science Museum for Young People, Yamaguchi Prefecture; Wakatsuki Plastic Surgery Hospital, Niigata Prefecture; Hokuto Corporation, Aichi Prefecture; Industrial Research Institute, Ishikawa Prefecture; Shonan Institute of Technology, Kanagawa Prefecture; Gyosen Oil Co., Tokyo; Tamana Senior High School, Kumamoto Prefecture; Yukiyoshi Clinic, Niigata Prefecture; Saishoen Social Welfare Corporation; Akishimadai Kindergarten; Azabu Veterinarian School Group; Ueki-Kita Junior High School, Ueki Town; Garden of Longevity, Isen Town; Takamatsu Primary School, Takamatsu Town; Himeji Red Cross Hospital; and Kita-Daito Island Branch, Okinawa Electric Power Company, Inc. Mentioned in this report are the outlines of the photovoltaic power generation field test, the results of joint research, expected technical effect, enlightening effect, troubles involving power generation systems, and so forth. (NEDO)

  13. Taxonomic review of the Sebastes pachycephalus complex (Scorpaeniformes: Scorpaenidae).

    Science.gov (United States)

    Kai, Yoshiaki; Nakabo, Tetsuji

    2013-01-01

    A taxonomic review of the Sebastes pachycephalus complex established the existence of two valid species, S. pachycephalus and S. nudus. Similarities between them include: cranium armed dorsally with robust preocular, supraocular, postocular, and parietal spines; interorbital space concave; lower jaw lacking scales, shorter than upper jaw; thickened rays in ventral half of pectoral fin; dorsal fin usually with 13 spines and 12 soft-rays; pored lateral line scales 27-35 (usually 29-33). However, S. pachycephalus is distinguishable from the latter in having minute scales below the entire dorsal-fin spine base (vs. lacking minute scales below first to fifth or variously to the posteriormost spine in the latter), dark spots scattered on the dorsal, anal and caudal fins (vs. no distinct dark spots), and lacking distinct colored markings on the dorsum (vs. yellow or reddish-brown markings present). Although both species occur off the southern Korean Peninsula and in the Bohai and Yellow Seas, in Japanese waters, the former is distributed from northern Honshu Is. southward to southern Kyushu Is., whereas the latter extends from southern Hokkaido southward along the Pacific coast of Japan to Kanagawa, and along the Sea of Japan coast to northern Kyushu Is., including the Seto Inland Sea. Sebastes nigricaus, S. nigricans, and S. latus are confirmed as junior synonyms of S. pachycephalus, and S. chalcogrammus as junior synonym of S. nudus, based on the examination of type specimens.

  14. A case of cholestatic hepatitis associated with histologic features of acute cholangitis

    Directory of Open Access Journals (Sweden)

    Takeuchi H

    2011-11-01

    Full Text Available Hajime Takeuchi1, Toru Kaneko1, Toshikazu Otsuka1, Kumiko Tahara1, Tadashi Motoori2, Makoto Ohbu3, Masaya Oda4, Hiroaki Yokomori11Department of Internal Medicine; 2Division of Pathology, Kitasato Medical Center Hospital, Kitasato University, Saitama; 3Department of Pathology, School of Allied Health Sciences, Kitasato University, Sagamihara, Kanagawa; 4Department of Internal Medicine, Saitama Social Insurance Hospital, Saitama; 5Organized Center of Clinical Medicine, International University of Health and Welfare, Sanno Hospital, Tokyo, JapanAbstract: This report describes a case showing histologic features of acute cholangitis with an over-the-counter drug. A 48-year-old woman was diagnosed with general malaise and progressive jaundice. A thorough review of her medical history revealed that the patient had taken an over-the-counter drug, Pabron Gold®, which she had used previously, that may have caused liver injury. Laboratory investigations revealed jaundice and liver dysfunction. Endoscopic retrograde cholangiography detected no extrahepatic biliary duct dilatation or stones. Liver biopsy indicated acute cholangitis involving neutrophils and eosinophils. Electron microscopy revealed fragmented nuclei, indicating that the degenerative bile duct-related epithelial cells were in an apoptotic process.Keywords: liver injury, over-the-counter drug, histologic features, acute cholangitis, electron microscopy, Pabron Gold

  15. Chum salmon egg extracts induce upregulation of collagen type I and exert antioxidative effects on human dermal fibroblast cultures

    Directory of Open Access Journals (Sweden)

    Yoshino A

    2016-08-01

    Full Text Available Atsushi Yoshino,1 Natalia Polouliakh,1–3 Akira Meguro,1 Masaki Takeuchi,1,4 Tatsukata Kawagoe,1 Nobuhisa Mizuki1 1Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, 2Sony Computer Science Laboratories Inc., Fundamental Research Laboratories, 3Systems Biology Institute, Tokyo, Japan; 4Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA Abstract: Components of fish roe possess antioxidant and antiaging activities, making them potentially very beneficial natural resources. Here, we investigated chum salmon eggs (CSEs as a source of active ingredients, including vitamins, unsaturated fatty acids, and proteins. We incubated human dermal fibroblast cultures for 48 hours with high and low concentrations of CSE extracts and analyzed changes in gene expression. Cells treated with CSE extract showed concentration-dependent upregulation of collagen type I genes and of multiple antioxidative genes, including OXR1, TXNRD1, and PRDX family genes. We further conducted in silico phylogenetic footprinting analysis of promoter regions. These results suggested that transcription factors such as acute myeloid leukemia-1a and cyclic adenosine monophosphate response element-binding protein may be involved in the observed upregulation of antioxidative genes. Our results support the idea that CSEs are strong candidate sources of antioxidant materials and cosmeceutically effective ingredients. Keywords: fish egg, antiaging, gene expression analysis, antioxidative gene, phylogenetic footprinting analysis

  16. Primary care patient experience and cancer screening uptake among women: an exploratory cross-sectional study in a Japanese population.

    Science.gov (United States)

    Aoki, Takuya; Inoue, Machiko

    2017-01-01

    Patient experience and clinical quality, which are represented by preventive care measures such as cancer screening, are both widely used for the evaluation of primary care quality. The aim of this study was to examine the association between patient experience and cancer screening uptake among women in a Japanese population. We conducted a cross-sectional mail survey. The questionnaire was sent to 1000 adult female residents randomly selected from a basic resident register in Yugawara town, Kanagawa, Japan. We assessed patient experience of primary care using a Japanese version of Primary Care Assessment Tool (JPCAT) and uptake of breast and cervical cancer screening. The overall response rate was 46.5%. Data were analyzed for 190 female participants aged 21-74 years who had a usual source of primary care. Multivariate logistic regression analyses revealed that the JPCAT total score was significantly associated with uptake of breast cancer screening [odds ratio (OR) per 1 standard deviation increase = 1.63; 95% CI 1.11-2.41], but not with uptake of cervical cancer screening (OR per 1 standard deviation increase = 1.47; 95% CI 0.97-2.24). Patient experience of primary care was associated with uptake of breast cancer screening among Japanese women. The results of our study might support the argument that patient experience of primary care and the clinical process of preventive care, such as breast cancer screening, are linked.

  17. Systemic lupus erythematosus: strategies to improve pregnancy outcomes

    Directory of Open Access Journals (Sweden)

    Yamamoto Y

    2016-07-01

    Full Text Available Yuriko Yamamoto, Shigeru Aoki Perinatal Center for Maternity and Neonate, Yokohama City University Medical Center, Yokohama, Kanagawa Prefecture, Japan Abstract: Systemic lupus erythematosus (SLE is a chronic autoimmune inflammatory disease with a high prevalence in females of childbearing age. Thus, reproduction in SLE patients is a major concern for clinicians. In the past, SLE patients were advised to defer pregnancy because of poor pregnancy outcomes and fear of SLE flares during pregnancy. Investigations to date show that maternal and fetal risks are higher in females with SLE than in the general population. However, with appropriate management of the disease, sufferers may have a relatively uncomplicated pregnancy course. Factors such as appropriate preconception counseling and medication adjustment, strict disease control prior to pregnancy, intensive surveillance during and after pregnancy by both the obstetrician and rheumatologist, and appropriate interventions when necessary play a key role. This review describes the strategies to improve pregnancy outcomes in SLE patients at different time points in the reproduction cycle (preconception, during pregnancy, and postpartum period and also details the neonatal concerns. Keywords: systemic lupus erythematosus, pregnancy outcomes, lupus flare

  18. Construction of five-piece segment using high-fluidity concrete; Koryudo togo bunkatsu segment no seko jisseki

    Energy Technology Data Exchange (ETDEWEB)

    Suda, Y.; Fukuzawa, I.; Matsunaga, H. [Tokyo Electric Power Co. Inc., Tokyo (Japan)

    1998-09-05

    After reviewing RC segment materials and the number of joints required, a segment of five equal pieces using high-fluidity concrete is employed in conduit construction work (for 500kV transmission lines) near Hommoku Wharf, Kanagawa Prefecture, which is for reduction in the shield tunnel construction cost (segment cost rate approximately 1/3). The use of high-fluidity concrete raises the materials cost a little but the factory overhead, expenditures for fabrication and formwork construction are lowered because some working processes may be dispensed with, such as the processes of compaction by vibration, surface finish, and formwork movement, and because the formwork main body may be simplified in structure. Although the standard tunnel specifications mention a segment consisting of 6 pieces, the 5-piece segment adopted in this construction work lowers the cost approximately 20% thanks to reduction in the numbers of joints between segment pieces and between rings. In the shield tunnelling process, assembly is easier and the construction work is executed without hitches deserving special mention. The new technique is comparable to the conventional ones in terms of quality and process management. Since the number of joints per piece between rings is reduced from the 3 in the conventional method to the 2 in this new method, two core-sensing pins are provided per piece between rings for assuring accuracy and shortening time in assembling. 2 refs., 8 figs., 11 tabs.

  19. Study of electrical power facilities and measures for planned outages in Japanese hemodialysis clinics after the Great East Japan Earthquake.

    Science.gov (United States)

    Ishida, Kai; Sawa, Manami; Fujiwara, Kousaku; Hirose, Minoru; Tsuruta, Harukazu; Takeuchi, Akihiro; Ikeda, Noriaki

    2013-02-01

    The Great East Japan Earthquake on 11 March 2011 caused major damage in northeastern Japan. The Kanto region experienced a massive electrical power shortage in the summer of 2011. A questionnaire was submitted to 354 hemodialysis clinics in Kanagawa prefecture and the Tokyo metropolitan area, excluding isolated islands, and 176 responses were analyzed (49.7%). The questions included evaluation of the availability of a private electricity generator, countermeasures in case of a planned outage, awareness of saving electricity, and improvement of safety of medical devices or electrical facilities after the earthquake. Only 12% of the clinics had private electricity generators and many clinics had no plans to introduce this facility. However, 96% of the clinics had established countermeasures to deal with a planned outage. Many clinics planned to provide dialysis on a different day or at a different time. All clinics had tried hard to establish procedures to save electricity in the summer of 2011, and 84% of the clinics had reconsidered and improved the safety of medical devices or electricity facilities after the earthquake. These results show that the awareness of crisis management was greatly improved in the wake of the earthquake.

  20. Proceedings of international symposium on radiation education (ISRE 98)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-09-01

    The International Symposium on Radiation Education, which commemorates the centenary of the discovery of radium by the Curies, was held on December 11-14, 1998 in Kanagawa, Japan. At present, radiation and radioactivity are not indispensable in medical diagnosis and treatment, but also are widely used in scientific research and industrial activities. Nuclear power generation is also playing an important role in saving nonrenewable natural energy resources, and without producing the potentially hazardous carbon dioxide. However, a majority of people has a insufficient knowledge or information about radiation and radioactivity. The symposium intended to generalize the scientific knowledge about radiation and radioactivity and also about various aspects of risks associated with the life in the civilized society, by discussing how to improve education in general and young generations at schools in particular, and by exchanging the newest scientific information relevant to the education. The symposium consisted of 5 sessions with 61 submitted papers, and involved about 170 participants from Australia, Bangladesh, France, Germany, Hungary, Indonesia, Korea, Philippine, Pakistan, Thailand, Turkey, UK and USA. (author)

  1. [Serotypes of urease producing Vibrio parahaemolyticus and their relation to possession of tdh and trh genes].

    Science.gov (United States)

    Suzuki, N; Ueda, Y; Mori, H; Miyagi, K; Noda, K; Hirose, H; Oosumi, Y; Ishibashi, M; Yoh, M; Yamamoto, K

    1994-09-01

    We analysed 467 isolates of Vibrio parahaemolyticus for possession of tdh/trh gene in comparison with urease production and serotypes. Strains possessing tdh+/trh-, tdh+/trh+, tdh-/trh-, and tdh-/trh- show positive urease production 2.1, 100, 65.7, 100%, respectively. Serotypes of O1:K69, O3:K6, O3:K72, O6:K18, O6:K46 and O1:KUT were frequently positive (100% except 91.7% of the latest one) in urease production. All isolates of O3:K6 prossessed trh, whereas all isolates of certain serotypes including O1:K69 and O3:K72 possessed both trh and trh and tdh genes. Among these, most of O1:K69 and O3:K72 were urease producer. From these results, we speculate that urease production is closely related to the presence of the trh gene or/and lesser production of TDH. We also found the new combination of serovar, O3:K25, O4:K37 and O13:K72 in Kanagawa phenomenon-positive strains.

  2. Vibrio parahaemolyticus CalR down regulates the thermostable direct hemolysin (TDH) gene transcription and thereby inhibits hemolytic activity.

    Science.gov (United States)

    Zhang, Yiquan; Zhang, Ying; Gao, He; Zhang, Lingyu; Yin, Zhe; Huang, Xinxiang; Zhou, Dongsheng; Yang, Huiying; Yang, Wenhui; Wang, Li

    2017-03-04

    TDH, encoded by tdh gene, is a major virulent determinant of V. parahaemolyticus that controls various biological activities, such as hemolytic activity, cytotoxicity, and enterotoxicity. The hemolytic activity on Wagatsuma agar ascribed to TDH is called Kanagawa phenomenon (KP). All KP positive strains contain tdh1 and tdh2 genes, but tdh2 is predominantly responsible for KP. CalR is a regulatory protein that was originally identified as a repressor of swarming motility and T3SS1 gene expression in V. parahaemolyticus. In the present study, the regulation of tdh2 by CalR was investigated using a set of experiments including qRT-PCR, primer extension, LacZ fusion, hemolytic phenotype, EMSA, and DNase I footprinting assays. The results showed that His-CalR protected a single region from 224bp to 318bp upstream of tdh2 against DNase I digestion, and a transcriptional start site located at 42bp upstream of tdh2 was detected and its transcribed activity was inhibited by CalR. Moreover, the KP test results showed that the hemolytic activity of V. parahaemolyticus is also under negative control of CalR. The data demonstrated that CalR is a repressor of the tdh2 transcription and thereby inhibits the hemolytic activity of V. parahaemolyticus.

  3. Protein cages, rings and tubes: useful components of future nanodevices?

    Directory of Open Access Journals (Sweden)

    Jonathan G Heddle

    2008-11-01

    Full Text Available Jonathan G HeddleGlobal Edge Institute, Tokyo Institute of Technology, Nagatsuda, Midori-ku, Yokohama Kanagawa, JapanAbstract: There is a great deal of interest in the possibility that complex nanoscale devices can be designed and engineered. Such devices will lead to the development of new materials, electronics and smart drugs. Producing complex nanoscale devices, however will present many challenges and the components of such devices will require a number of special features. Devices will be engineered to incorporate desired functionalities but, because of the difficulties of controlling matter precisely at the nanoscale with current technology, the nanodevice components must self-assemble. In addition, nanocomponents that are to have wide applicability in various devices must have enough flexibility to integrate into a large number of potentially very different environments. These challenges are daunting and complex, and artificial nanodevices have not yet been constructed. However, the existence of nanomachines in nature in the form of proteins (eg, enzymes suggests that they will be possible to produce. As the material from which nature’s nanomachines are made, proteins seem ideal to form the basis of engineered components of such nanodevices. Initially, engineering projects may focus on building blocks such as rings, cages and tubes, examples of which exist in nature and may act as a useful start point for modification and further development. This review focuses on the recent research and possible future development of such protein building blocks.Keywords: bionanotechnology, protein engineering, nanomachine, building-blocks, synthetic biology

  4. Molecular detection and characterization of Influenza 'C' viruses from western India.

    Science.gov (United States)

    Potdar, V A; Hinge, D D; Dakhave, M R; Manchanda, A; Jadhav, N; Kulkarni, P B; Chadha, M S

    2017-10-01

    Since 2003, India has had a well-established influenza surveillance network, though Influenza C virus was not the focus of study. We therefore retrospectively analyzed clinical samples from Pune, western India collected during January 2009 to August 2015, by real-time RT-PCR. Three of 2530 samples of patients with influenza-like illness (ILI) or severe acute respiratory illness (SARI) showed positivity for Influenza C virus infection, while 105 and 31 samples were positive for Influenza A and B viruses respectively. Influenza C viruses were successfully isolated using the embryonated egg system and whole genomes were sequenced and analyzed phylogenetically. HE gene-based phylogeny showed that two viruses C/India/P119564/2011 and C/India P121719/2012 clustered with the C/Sao Paulo/378/82 (SP82) lineage, whereas C/India/P135047/2013 clustered with the C/Kanagawa/1/76 (KA76) lineage. The internal gene of these viruses grouped in two lineages. The PB1, PB2, M and NS genes of the study viruses grouped with C/Yamagata/26/81 (YA81), while the P3 (PA) and NP genes grouped with C/Mississippi/80 (MS80). Bayesian clock studies conclude that the Indian strains may have emerged through multiple reassortment events. Copyright © 2017 Elsevier B.V. All rights reserved.

  5. Hematology and serum biochemistry in debilitated, free-ranging raccoon dogs (Nyctereutes procyonoides) infested with sarcoptic mange.

    Science.gov (United States)

    Kido, Nobuhide; Kamegaya, Chihiro; Omiya, Tomoko; Wada, Yuko; Takahashi, Maya; Yamamoto, Yasuhiko

    2011-12-01

    Frequent outbreaks of Sarcoptes scabiei infestation in raccoon dogs (Nyctereutes procyonoides) have been reported in Japan. Although many raccoon dogs are brought to Kanazawa Zoological Garden (Yokohama, Kanagawa, Japan) because of S. scabiei infestation and debilitation, some of them die of asthenia. The clinical status of severely debilitated raccoon dogs must be determined to save their lives. In this study, we compared hematological and serum biochemical values between severely debilitated and nondebilitated raccoon dogs infested with S. scabiei. The total protein, albumin, glucose, and calcium values of debilitated raccoon dogs were significantly lower than those of nondebilitated raccoon dogs. On the other hand, debilitated raccoon dogs had significantly higher aspartate aminotransferase, total bilirubin, blood urea nitrogen, sodium, chloride, and phosphorus values than did nondebilitated raccoon dogs. The increase in the blood urea nitrogen value was particularly dramatic. The present study revealed that debilitated raccoon dogs infested with S. scabiei exhibited abnormal hematological values compared with nondebilitated raccoon dogs infested with S. scabiei. Clinically, the raccoon dogs developed malnutrition and sepsis if the mange infestation was untreated. Moreover, dehydration associated with appetite loss may have resulted in insufficient renal perfusion. These findings suggest that chronic S. scabiei infestations debilitated the raccoon dogs and resulted in physiological changes that were detected with hematological and serum biochemical tests.

  6. Citizen participatory dioxin monitoring campaign by pine needles as biomonitor of ambient air dioxin pollution

    Energy Technology Data Exchange (ETDEWEB)

    Komichi, I.; Takatori, A. [Environmental Research Institute Inc., Tokyo (Japan); Aoyama, T. [Musashi Institute of Technology, Yokohama (Japan). Faculty of Environment and Informations; Vrzic, B. [Maxxam Analytics Inc. HRMS Laboratory, Waterloo, ON (Canada)

    2004-09-15

    The needle-type leaves of Japanese black pine trees (hereafter abbreviated as pine needles) have been used as an effective bio-monitor of ambient air pollution. Miyata Laboratory of Setsunan University has reported that the pine needles accumulate PCDDs and PCDFs (hereafter abbreviated as D/F) through photosynthesis and respiration during their lifetime. On the basis of this study, we have revealed the correlation between ambient air and pine needle concentrations to be estimated at or near 1:10 by analyzing long term continuous ambient dioxin monitoring data and that of pine needles sampled from the same area as ambient air in the Kanagawa Prefecture in 1999. Since then, the citizen groups of each local area all over Japan have started monitoring the ambient air dioxin concentration levels by using pine needles. Samples analyzed during these 5 years totaled more than 650 throughout Japan. The results of these citizen participatory environmental monitoring activities are the tremendous effects achieved in reducing the dioxin levels. This occurs through observation of the dioxin emission sources such as Municipal Solid Waste Incineration Plants as well as the Industrial Waste Incineration plants, which exist in numbers exceeding several thousands in Japan. This short paper will present the results of 56 municipalities of western Japan where ambient air dioxin levels have improved steadily against local averages during these 5 years.

  7. Education effect of solar car for technical high school student; Kogyo kokosei ni taisuru solar car no kyoiku koka

    Energy Technology Data Exchange (ETDEWEB)

    Inoue, T.

    1998-09-30

    The solar car race which technical high school students can join in was determined to be held at Ogata village, Akita prefecture. To join in the solar bicycle race, the author working in Ofuna technical high school called on 3 schools of Yokosuka, Fujisawa and Kanagawa technical high schools which joined in World Solar-Car Rally in Akita (WSR) in 1997, before fabrication of a racing bicycle. This paper describes the survey results at the above technical high schools, and the spirit as the teacher of Ofuna technical high school on joining in the race and fabrication of the solar bicycle, and the past, current and future situations. Club activities of high school students incline too toward sports such as soccer, baseball, volleyball and rugby, and are apt to keep honest cultural events and technical events at a distance. The author says that the challenge spirit to the solar car race using environment-friendly solar energy by both dedicated teachers and students of technical high schools summoned up the author`s courage. 15 figs.

  8. Load leveling air conditioning technology development by unused energy high-level utilization. Summary of lectures given at the achievement report meeting; Miriyo energy kodo katsuyo fuka heijunka reidanbo gijutsu kaihatsu. Seika hokokukai koen yoshishu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-01-01

    This paper summarizes lectures given at the research and development achievement report meeting on load leveling air conditioning technologies utilizing unutilized energies at high levels. The lecture titled 'the current status and future problems in heat supply industries' given by the manager of the Heat Supply Industry Department at the Agency of Natural Resources and Energy explained the heat supply businesses in relation with global environment issues, electric power load leveling, and cogeneration. The lecture titled 'improvement of cities to energy saving type cities and district air conditioning systems' given by a construction official at the Ministry of Construction explained the guideline (draft) for introduction of district air conditioning systems as to their purpose, positioning, procedure for discussing the introduction, and procedure for its implementation as a business. The lecture titled 'the recent trend inside and outside the country around unutilized energies' given by Professor Tanazawa at the Tokyo University of Agriculture and Technology described the intensification of energy problems, environment problems, and the near future measures to be taken against these problems. The lecture titled 'summarization of the achievements in development of load leveling air conditioning technologies utilizing unutilized energies at high levels' given by Professor Nakahara at the Kanagawa University explained the summary of the achievements in research and development by themes. (NEDO)

  9. The enhanced dissolution of some chlorinated hydrocarbons and monocyclic aromatic hydrocarbons in rainwater collected in Yokohama, Japan

    Science.gov (United States)

    Okochi, Hiroshi; Sugimoto, Daisuke; Igawa, Manabu

    By simultaneous sequential sampling of gas and rainwater from 1999 to 2000 in the campus of Kanagawa University in Yokohama, Japan, we investigated the wet-scavenging process of volatile organic compounds, some chlorinated hydrocarbons (CHs) and monocyclic aromatic hydrocarbons (MAHs), via rain droplets. Their volume-weighted mean concentrations in 125 rainwater were 4.98 nM for dichloromethane, 3.71 nM for toluene, 2.00 nM for benzene, 0.93 nM for 1,2-dichloroethane, 0.62 nM for o-xylene, 0.57 nM for m, p-xylene, 0.51 nM for p-dichlorobenzene, and 0.35 nM for trichloromethylene. Their rainwater concentrations did not depend on the rainfall intensity, and the temporal variation of their concentrations was similar to that of gas-phase concentrations. The dissolution of CHs and MAHs into rainwater, however, was larger than expected from their gas-phase concentrations at the ground and their temperature-corrected Henry's law constants. A simple below-cloud scavenging model, which was developed by Levine and Schwartz (Atmos. Environ. 16 (1982) 1725) could explain the independence of the rainfall intensity but not explain their enhanced dissolution in rainwater. The results of this study indicate the estimated concentrations, which were based on the Henry's law equilibrium, considerably underestimate the wet-deposition fluxes of CHs and MAHs onto the ground.

  10. Molecular Diversity and Predictability of Vibrio parahaemolyticus along the Georgian coastal zone of the Black Sea

    Directory of Open Access Journals (Sweden)

    Bradd J. Haley

    2014-02-01

    Full Text Available Vibrio parahaemolyticus is a leading cause of seafood-related gastroenteritis and is also an autochthonous member of marine and estuarine environments worldwide. One hundred seventy strains of V. parahaemolyticus were isolated from water and plankton samples collected along the Georgian coast of the Black Sea during 28 months of sample collection. All isolated strains were tested for presence of tlh, trh, and tdh. A subset of strains were serotyped and tested for additional factors and markers of pandemicity. Twenty-six serotypes, five of which are clinically relevant, were identified. Although all 170 isolates were negative for tdh, trh, and the Kanagawa Phenomenon, 7 possessed the GS-PCR sequence and 27 the 850 bp sequence of V. parahaemolyticus pandemic strains. The V. parahaemolyticus population in the Black Sea was estimated to be genomically heterogeneous by rep-PCR and the serodiversity observed did not correlate with rep-PCR genomic diversity. Statistical modeling was used to predict presence of V. parahaemolyticus as a function of water temperature, with strongest concordance observed for Green Cape site samples (Percent of total variance = 70, P < 0.001. Results demonstrate a diverse population of V. parahaemolyticus in the Black Sea, some of which carry pandemic markers, with increased water temperature correlated to an increase in abundance of V. parahaemolyticus.

  11. [Seamless community coordination of rehabilitation nutrition care management in patients with Dysphagia].

    Science.gov (United States)

    Wakabayashi, Hidetaka

    2010-12-01

    Community coordination is necessary in nutrition care management and dysphagia rehabilitation, because they are not completed in one hospital or facility. For seamless community coordination of rehabilitation nutrition care management in patients with dysphagia, it is useful to define why, who, when, where, what, and how. Common communication materials of nutrition support team and dysphagia rehabilitation made by Kanagawa society of dysphagia rehabilitation is effective in promoting community coordination. In qualitative research for participants in community nutrition support team at Yokohama south area, two issues were emerged: strengthening collaboration of the community nutrition support team including visiting medical staffs and offering opportunity to learn clinical nutrition and dysphagia rehabilitation. Concept of rehabilitation nutrition is also useful for community coordination. Rehabilitation nutrition is to assess with the International Classification of Functioning, Disability and Health including nutrition status and to practice rehabilitation nutrition care plan under adequate prognosis prediction. It is not enough for patients with dysphagia to coordinate only clinical nutrition or rehabilitation. Seamless community coordination of rehabilitation nutrition care management is important for patients with dysphagia to improve their activities of daily living and quality of life.

  12. Detection and identification of the Candida species by 25S ribosomal DNA analysis in the urine of candidal cystitis.

    Science.gov (United States)

    Kano, Rui; Hattori, Yousuke; Okuzumi, Katsuko; Miyazaki, Yoshio; Yamauchi, Rie; Koie, Hiroshi; Watari, Toshihiro; Hasegawa, Atsuhiko

    2002-02-01

    Candida species in clinical urine samples were identified directly by the newly developed method of PCR analysis on 25S ribosomal DNA (rDNA). Two dogs were referred to the Animal Medical Center, Nihon University School of Veterinary Medicine, Fujisawa, Kanagawa, Japan for the examination of chronic cystitis. Microscopic examination of urine samples from these dogs revealed yeast cells. Urine culture on Sabouraud's dextrose agar at 27 degrees C for 5 days produced white to cream colored colonies. The isolates were identifical to Candida albicans and C. parapsilosis by mycological examination, respectively. The nucleotide sequences of 25S ribosomal DNA from these urine isolates showed 99% similarity to those of a reference strain of Candida albicans or C. parapsilosis. The nucleotide sequences of 25S rDNA obtained directly from urine samples were also identical to C. albicans and C. parapsilosis, respectively. Confirming the results on the isolates cultured from the same urine samples. This PCR analysis method could be available for the direct identification of Candida species in urine samples within 2 days.

  13. Development of Social Recommendation GIS for Tourist Spots

    Directory of Open Access Journals (Sweden)

    Tsukasa IKEDA

    2014-12-01

    Full Text Available This study aims to develop a social recommendation media GIS (Geographic Information Systems specially tailored to recommend tourist spots. The conclusions of this study are summarized in the following three points. (1 Social media GIS, an information system which integrates Web-GIS, SNS and recommendation system into a single system, was conducted in the central part of Yokohama City in Kanagawa Prefecture, Japan. The social media GIS uses a design which displays its usefulness in reducing the constraints of information inspection, time and space, and continuity, making it possible to redesign systems in accordance with target cases. (2 The social media GIS was operated for two months for members of the general public who are more than 18 years old. The total numbers of users was 98, and the number of pieces of information submitted was 232. (3 The web questionnaires of users showed the usefulness of the integration of Web-GIS, SNS and recommendation systems, because the functions of reference and recommendation can be expected to support tourists’ excursion behavior. Since the access survey of log data showed that about 35% of accesses were from mobile information terminals, it can be said that the preparation of an optimal interface for such terminals was effective.

  14. Rapid evaluation of fibrinogen levels using the CG02N whole blood coagulation analyzer.

    Science.gov (United States)

    Hayakawa, Mineji; Gando, Satoshi; Ono, Yuichi; Mizugaki, Asumi; Katabami, Kenichi; Maekawa, Kunihiko; Miyamoto, Daisuke; Wada, Takeshi; Yanagida, Yuichiro; Sawamura, Atsushi

    2015-04-01

    Rapid evaluation of fibrinogen (Fbg) levels is essential for maintaining homeostasis in patients with massive bleeding during severe trauma and major surgery. This study evaluated the accuracy of fibrinogen levels measured by the CG02N whole blood coagulation analyzer (A&T Corporation, Kanagawa, Japan) using heparinized blood drawn for blood gas analysis (whole blood-Fbg). A total of 100 matched pairs of heparinized blood samples and citrated blood samples were simultaneously collected from patients in the intensive care unit. Whole blood-Fbg results were compared with those of citrated plasma (standard-Fbg). The whole blood coagulation analyzer measured fibrinogen levels within 2 minutes. Strong correlations between standard-Fbg and whole blood-Fbg were observed (ρ = 0.91, p blood-Fbg was 0.980 (95% confidence interval 0.951-1.000, p blood coagulation analyzer can rapidly measure fibrinogen levels in heparinized blood and could be useful in critical care settings where excessive bleeding is a concern.

  15. Engineering technologies for steel structure applied to Trans-Tokyo bay highway project; Tokyowan odan doro ni okeru kokozo gijutsu

    Energy Technology Data Exchange (ETDEWEB)

    Furumuro, K.; Kobayashi, T.; Kanda, K. [Kawasaki Steel Corp., Tokyo (Japan)

    1996-03-01

    The Trans-Tokyo Bay Highway is a 15.1 km toll road that spans the Tokyo Bay from Kawasaki City in Kanagawa Prefecture to Kisarazu City in Chiba Prefecture by a bridge, an undersea shield tunnel, and two man-made islands. Many new technologies and methods were introduced to construct a large-scale structure safely, rationally, and in a short time on the weak ground under the depth of water in a seismic region such as Tokyo Bay. Kawasaki Steel participated in this project in: (1) development and construction of a revetment structure to which the technology of an oil drilling jacket was applied, (2) design and construction of a large-sized bridge with long-span and multi-span continuous girders on the sea, and (3) design and installation of a mud water treatment module for the shield tunnel constructed on the sea. As a result, the bearing-capacity measurement technology based on the dynamic method of a large diameter steel pipe pile was developed in item (1). The long-term corrosion-proof method using titanium clad steel was developed in item (2), and the way to construct the treatment facilities of approximately 5100 tons in item (3). 3 refs., 12 figs.

  16. Comparative study of treatment continuation using second-generation antipsychotics in patients with schizophrenia or schizoaffective disorder

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    Azekawa T

    2011-11-01

    Full Text Available Takaharu Azekawa, Shizuko Ohashi, Akira ItamiShioiri Mental Clinic, Yokosuka-shi, Kanagawa-ken, JapanBackground: Effectiveness of a drug is a key concept dependent on efficacy, safety, and tolerability. Time to discontinuation of treatment is also representative of effectiveness. We investigated differences in treatment discontinuation among newly started second-generation antipsychotics in the clinical setting.Methods: Using a retrospective cohort study design, we screened all outpatients (n = 7936 who visited the Shioiri Mental Clinic between July 1, 2008 and June 30, 2010. We identified a cohort of patients (n = 703 diagnosed with schizophrenia or schizoaffective disorder and calculated the time to discontinuation of each second-generation antipsychotic.Results: Of the 703 patients, 149 were newly treated with aripiprazole, 67 with blonanserin, 95 with olanzapine, 36 with quetiapine, 74 with perospirone, and 120 with risperidone. The time to discontinuation for all causes was significantly longer for aripiprazole than for blonanserin, olanzapine, and risperidone. In addition, aripiprazole tended to be continued for longer than quetiapine and perospirone, but these differences were not significant.Conclusion: Aripiprazole may be considered the best available option for long-term treatment of patients with schizophrenia or schizoaffective disorder.Keywords: retrospective study, second-generation antipsychotics, effectiveness, treatment continuation, schizophrenia, aripiprazole

  17. Profile of blonanserin for the treatment of schizophrenia

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    Tenjin T

    2013-04-01

    Full Text Available Tomomi Tenjin, Seiya Miyamoto, Yuriko Ninomiya, Rei Kitajima, Shin Ogino, Nobumi Miyake, Noboru YamaguchiDepartment of Neuropsychiatry, St Marianna University School of Medicine, Kawasaki, Kanagawa, JapanAbstract: Blonanserin was developed as an antipsychotic drug in Japan and approved for the treatment of schizophrenia. It belongs to a series of 4-phenyl-2-(1-piperazinylpyridines and acts as an antagonist at dopamine D2, D3, and serotonin 5-HT2A receptors. Blonanserin has low affinity for 5-HT2C, adrenergic α1, histamine H1, and muscarinic M1 receptors, but displays relatively high affinity for 5-HT6 receptors. In several short-term double-blind clinical trials, blonanserin had equal efficacy as haloperidol and risperidone for positive symptoms in patients with chronic schizophrenia and was also superior to haloperidol for improving negative symptoms. Blonanserin is generally well tolerated and has a low propensity to cause metabolic side effects and prolactin elevation. We recently reported that blonanserin can improve some types of cognitive function associated with prefrontal cortical function in patients with first-episode and chronic schizophrenia. Taken together, these results suggest that blonanserin may be a promising candidate for a first-line antipsychotic for acute and maintenance therapy for schizophrenia. Further comparative studies are warranted to clarify the benefit/risk profile of blonanserin and its role in the treatment of schizophrenia.Keywords: blonanserin, schizophrenia, pharmacology, pharmacokinetics, efficacy, safety

  18. Preliminary study for creation of kelp forest(part 1). Seasonal changes of lamina and growth of root of eisenia bicyclis in Odawa bay, Miura peninsula. Kaichurin zosei gijutsu no kisoteki kento (Part 1). Miurahanto Odawawan ni okeru arame yobu no kisetsutekihenka to ne no seicho

    Energy Technology Data Exchange (ETDEWEB)

    Terawaki, Toshinobu; Goto, Hiroshi

    1988-02-01

    Preliminary study for creation of kelp forest has been carried in Odawa bay, Kanagawa Prefecture. In foreshore reclamation in electric power plant siting, the restoration and substitute measures of kelp forest have become important for the protection of living aquatic resources and marine environment, it is an urgent need to develop artificial creation of kelp forest. Observations on seasonal changes of lamina and growth of root of Eisenia bicyclis were carried out during July 1984 to October 1985. The maximum weight of lamina reached about 600g during July to August, then it decreased and became minimum weight of 120g in November. Maturation period were observed during September to next March. Primary pinnae length reached maximum of 57cm during March to April and became minimum of 30cm in October. It's width reached maximum of 9cm in July and became minimum of 6cm in November. Growth of new root occured in October, it reached rock-bed exceeding old root in next April. New root weight occupied 40% of whole holdfast weight. Duration of November to February, in which maturation and growth of root are active, is important season for the preservation of Eisenia bicyclis population, and is suitable for seeding and transplanting. (14 figs, 2 tabs, 15 refs)

  19. [Treatment approaches for synthetic drug addiction].

    Science.gov (United States)

    Kobayashi, Ohji

    2015-09-01

    In Japan, synthetic drugs have emerged since late 2000s, and cases of emergency visits and fatal traffic accidents due to acute intoxication have rapidly increased. The synthetic drugs gained popularity mainly because they were cheap and thought to be "legal". The Japanese government restricted not only production and distribution, but also its possession and use in April 2014. As the synthetic drug dependent patients have better social profiles compared to methamphetamine abusers, this legal sanction may have triggered the decrease in the number of synthetic drug dependent patient visits observed at Kanagawa Psychiatric Center since July 2014. Treatment of the synthetic drug dependent patients should begin with empathic inquiry into the motives and positive psychological effects of the drug use. In the maintenance phase, training patients to trust others and express their hidden negative emotions through verbal communications is essential. The recovery is a process of understanding the relationship between psychological isolation and drug abuse, and gaining trust in others to cope with negative emotions that the patients inevitably would face in their subsequent lives.

  20. PREFACE: The International Conference on Science of Friction

    Science.gov (United States)

    Miura, Kouji; Matsukawa, Hiroshi

    2007-07-01

    The first international conference on the science of friction in Japan was held at Irago, Aichi on 9-13 September 2007. The conference focused on the elementary process of friction phenomena from the atomic and molecular scale view. Topics covered in the conference are shown below.: Superlubricity and friction Electronic and phononic contributions to friction Friction on the atomic and molecular scales van der Waals friction and Casimir force Molecular motor and friction Friction and adhesion in soft matter systems Wear and crack on the nanoscale Theoretical studies on the atomic scale friction and energy dissipation Friction and chaos Mechanical properties of nanoscale contacts Friction of powder The number of participants in the conference was approximately 100, registered from 11 countries. 48 oral and 29 poster talks were presented at the conference. This volume of Journal of Physics: Conference Series includes 23 papers devoted to the above topics of friction. The successful organization of the conference was made possible by the contribution of the members of the Organizing Committee and International Advisory Committee. The conference was made possible thanks to the financial support from Aichi University of Education and the Taihokogyo Tribology Research Foundation (TTRF), and moreover thanks to the approval societies of The Physical Society of Japan, The Surface Science Society of Japan, The Japanese Society of Tribologists and Toyota Physical and Chemical Research Institute. The details of the conference are available at http://www.science-of-friction.com . Finally we want to thank the speakers for the high quality of their talks and all participants for coming to Irago, Japan and actively contributing to the conference. Kouji Miura and Hiroshi Matsukawa Editors

  1. Biological activity is the likely origin of the intersection between the photoreceptor inner and outer segments of the rat retina as determined by optical coherence tomography

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    Yamauchi Y

    2011-11-01

    Full Text Available Yasuyuki Yamauchi, Hiromichi Yagi, Yoshihiko Usui, Keisuke Kimura, Tsuyoshi Agawa, Rintaro Tsukahara, Naoyuki Yamakawa, Hiroshi GotoDepartment of Ophthalmology, Tokyo Medical University Hospital, Tokyo, JapanBackground: Recent research on macular diseases has prompted investigations into the condition of the intersection between the photoreceptor inner and outer segments (IS/OS and the relationship with retinal photoreceptor abnormalities. Although the origin of the IS/OS in optical coherence tomography (OCT images is unclear, it may be related to either the cellular activity of the photoreceptors or the structure of the OS disks. To address this question, we compared the IS/OS status in OCT images of rat retinas before and after euthanasia.Methods: OCT images were taken before and after euthanasia in four eyes of two Brown Norway rats. After the OCT images were taken, the rats were used for histopathological studies to confirm that retinal structures were intact.Results: Before euthanasia, the IS/OS and external limiting membrane (ELM line were clearly identifiable on the OCT images. However, after euthanasia, neither the IS/OS nor the ELM line was evident in three out of four eyes, and a faint IS/OS and an ELM line were identified in one eye. Histopathological analysis did not show any abnormalities in the retina in any of the four eyes.Conclusion: The origin of the IS/OS identified in OCT images is likely related to the biological activities of the photoreceptor cells.Keywords: IS/OS, OCT, histopathology, biological activity

  2. Blood pressure-independent effect of candesartan on cardio-ankle vascular index in hypertensive patients with metabolic syndrome

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    Kanako Bokuda

    2010-07-01

    Full Text Available Kanako Bokuda1, Atsuhiro Ichihara1,2, Mariyo Sakoda1, Asako Mito1, Kenichiro Kinouchi1, Hiroshi Itoh11Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan; 2Department of Endocrinology and Anti-Aging Medicine, Keio University School of Medicine, Tokyo, JapanAbstract: Angiotensin receptor blockers (ARBs are known to reduce the cardiovascular risk in hypertensive patients. This study was designed to examine the effect of an ARB candesartan on subclinical atherosclerosis assessed by cardio-ankle vascular index (CAVI in comparison with calcium channel blockers (CCBs alone in hypertensive patients with metabolic syndrome (MetS. A total of 53 consecutive hypertensive patients with MetS were randomly assigned to the candesartan group, in which candesartan was added on, or the CCBs group, in which CCBs were added on. Clinical and biological parameters were obtained before and after the 12-month treatment period. The primary measure of efficacy was the %change in CAVI. When treated with candesartan, but not CCBs, CAVI significantly decreased from 8.7 to 7.7 by 11%. Blood pressure (BP significantly decreased with both treatments, but the differences between groups were not significant. The changes in other parameters remained unchanged in both the groups. Analysis of covariance found that both the BP reduction and the therapy difference contributed to the decrease in CAVI, but the BP reduction was not involved in the decrease in CAVI caused by the difference in the therapy. Candesartan may be a better antihypertensive drug than CCBs to that subclinical atherosclerosis of patients with MetS.Keywords: albuminuria, ambulatory blood pressure, calcium channel blockers, carotid ­intima-media thickness

  3. Up-regulation of brain-derived neurotrophic factor in the dorsal root ganglion of the rat bone cancer pain model

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    Tomotsuka N

    2014-07-01

    Full Text Available Naoto Tomotsuka,1 Ryuji Kaku,1 Norihiko Obata,1 Yoshikazu Matsuoka,1 Hirotaka Kanzaki,2 Arata Taniguchi,1 Noriko Muto,1 Hiroki Omiya,1 Yoshitaro Itano,1 Tadasu Sato,3 Hiroyuki Ichikawa,3 Satoshi Mizobuchi,1 Hiroshi Morimatsu1 1Department of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan; 2Department of Pharmacy, Okayama University Hospital, Okayama, Japan; 3Department of Oral and Craniofacial Anatomy, Tohoku University Graduate School of Dentistry, Sendai, Japan Abstract: Metastatic bone cancer causes severe pain, but current treatments often provide insufficient pain relief. One of the reasons is that mechanisms underlying bone cancer pain are not solved completely. Our previous studies have shown that brain-derived neurotrophic factor (BDNF, known as a member of the neurotrophic family, is an important molecule in the pathological pain state in some pain models. We hypothesized that expression changes of BDNF may be one of the factors related to bone cancer pain; in this study, we investigated changes of BDNF expression in dorsal root ganglia in a rat bone cancer pain model. As we expected, BDNF mRNA (messenger ribonucleic acid and protein were significantly increased in L3 dorsal root ganglia after intra-tibial inoculation of MRMT-1 rat breast cancer cells. Among the eleven splice-variants of BDNF mRNA, exon 1–9 variant increased predominantly. Interestingly, the up-regulation of BDNF is localized in small neurons (mostly nociceptive neurons but not in medium or large neurons (non-nociceptive neurons. Further, expression of nerve growth factor (NGF, which is known as a specific promoter of BDNF exon 1–9 variant, was significantly increased in tibial bone marrow. Our findings suggest that BDNF is a key molecule in bone cancer pain, and NGF-BDNF cascade possibly develops bone cancer pain. Keywords: BDNF, bone cancer pain, chronic pain, nerve growth

  4. Tipepidine in adolescent patients with depression: a 4 week, open-label, preliminary study

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    Sasaki T

    2014-05-01

    Full Text Available Tsuyoshi Sasaki,1,2 Kenji Hashimoto,3 Masumi Tachibana,1 Tsutomu Kurata,1 Hiroshi Kimura,2 Hideki Komatsu,2 Masatomo Ishikawa,2 Tadashi Hasegawa,2 Akihiro Shiina,1 Tasuku Hashimoto,2 Nobuhisa Kanahara,4 Tetsuya Shiraishi,2 Masaomi Iyo1–41Department of Child Psychiatry, Chiba University Hospital, 2Department of Psychiatry, Chiba University Graduate School of Medicine, 3Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 4Division of Medical Treatment and Rehabilitation, Chiba University Center for Forensic Mental Health, Inohana, Chiba, JapanDepression in children and adolescents is a common, recurrent, and debilitating condition associated with increased psychosocial, and medical morbidity and mortality.1The global prevalence of depression in children and adolescents is 1%–2% and 3%–8%, respectively.2 Depressive symptoms are also associated with significant functional impairment in school and the work place (often requiring legal interventions,1–5 and an increased risk for substance abuse and suicide.6–9 Clinical guidelines suggest the use of two selective serotonin reuptake inhibitors (SSRI, namely fluoxetine and escitalopram, both of which are effective with generally acceptable safety profiles in the treatment of adolescent depression.10 Additionally, combination treatment with an SSRI and psychotherapy, typically cognitive behavioral therapy (CBT, has shown benefit in this cohort.10 However, caution is warranted since antidepressants therapy in children and adolescents is associated with increased rates of suicidal ideation11–13 and adverse effects, characterized by excessive emotional arousal or behavioral activation.14 These results highlight the need for new therapies in adolescent patients with depression, particularly therapies with fewer side effects.View original paper by Brent and Maalouf.

  5. Population pharmacokinetics of olprinone in healthy male volunteers

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    Kunisawa T

    2014-03-01

    Full Text Available Takayuki Kunisawa,1 Hidefumi Kasai,2 Makoto Suda,2 Manabu Yoshimura,3 Ami Sugawara,3 Yuki Izumi,3 Takafumi Iida,3 Atsushi Kurosawa,3 Hiroshi Iwasaki3 1Surgical Operation Department, Asahikawa Medical University Hospital, Hokkaido, Japan; 2Clinical Study Management Division, Bell Medical Solutions Inc, Tokyo, Japan; 3Department of Anesthesiology and Critical Care Medicine, Asahikawa Medical University, Hokkaido, Japan Background: Olprinone decreases the cardiac preload and/or afterload because of its vasodilatory effect and increases myocardial contractility by inhibiting phosphodiesterase III. Purpose: The objective of this study was to characterize the population pharmacokinetics of olprinone after a single continuous infusion in healthy male volunteers. Methods: We used 500 plasma concentration data points collected from nine healthy male volunteers for the study. The population pharmacokinetic analysis was performed using the nonlinear mixed effect model (NONMEM® software. Results: The time course of plasma concentration of olprinone was best described using a two-compartment model. The final pharmacokinetic parameters were total clearance (7.37 mL/minute/kg, distribution volume of the central compartment (134 mL/kg, intercompartmental clearance (7.75 mL/minute/kg, and distribution volume of the peripheral compartment (275 mL/kg. The interindividual variability in the total clearance was 12.4%, and the residual error variability (exponential and additive were 22.2% and 0.129 (standard deviation. The final pharmacokinetic model was assessed using a bootstrap method and visual predictive check. Conclusion: We developed a population pharmacokinetic model of olprinone in healthy male adults. The bootstrap method and visual predictive check showed that this model was appropriate. Our results might be used to develop the population pharmacokinetic model in patients. Keywords: phosphodiesterase III inhibitor, men, pharmacokinetic model

  6. Ineffectiveness of intrastromal voriconazole for filamentous fungal keratitis

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    Niki M

    2014-06-01

    Full Text Available Masanori Niki, Hiroshi Eguchi, Yuki Hayashi, Tatsuro Miyamoto, Fumika Hotta, Yoshinori MitamuraDepartment of Ophthalmology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima-shi, JapanPurpose: The purpose of this study is to describe the ineffectiveness of intrastromal voriconazole injection for filamentous fungal keratitis by contrasting the effectiveness for yeast keratitis.Methods: We examined seven fungal keratitis patients prospectively. All yeast was identified by molecular phylogenetic analyses of the chromosomal regions coding for the D1/D2 domain of the large-subunit 26S ribosomal RNA gene. All filamentous fungi were identified by the sequencing of internal transcribed spacers of the ribosomal DNA gene regions. Approximately 0.1 mL of voriconazole diluted with saline to 1.0% was injected with a 30-gauge needle inserted obliquely into the three to five clear cornea sites around the abscess. All subjects were administered natamycin ointment and oral itraconazole. When needed, intravenous micafungin, voriconazole, and/or intracameral voriconazole were added. Clinical courses were observed by the slit lamp microscope. Histopathology was examined when the corneas were removed.Results: All cases that were caused by yeast healed quickly after injections. Two cases of keratitis caused by Fusarium, and one case caused by Aspergillus, did not heal completely. In the Fusarium cases, additional antifungal medications (3.0% topical voriconazole and intravenous injection of micafungin were needed. After optical penetrating keratoplasty in one of the cases, fungi were found in the deep stroma of the removed cornea. In the case of Aspergillus keratitis, pathological findings also showed fungi deep in the stroma of the removed cornea and the keratitis recurred after therapeutic penetrating keratoplasty.Conclusion: Intrastromal voriconazole injection is successful in treating yeast keratitis. However this is not the

  7. Experimental effect of retinoic acids on apoptosis during the development of diabetic retinopathy

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    Nami Nishikiori

    2008-03-01

    Full Text Available Nami Nishikiori1,2, Makoto Osanai2, Hideki Chiba2, Takashi Kojima2, Shuichiro Inatomi1,2, Hiroshi Ohguro1, Norimasa Sawada2Departments of 1Ophthalmology and 2Pathology, Sapporo Medical University School of MedicinePurpose: This study was conducted to investigate whether retinoic acids (RAs had any effect on apoptosis during the development of diabetic retinopathy.Methods: To investigate whether RAs had any effect on apoptosis during the development of diabetic retinopathy, we housed 32 C57BL/6 male mice and induced diabetes in 24 by intra peritoneal injections of streptozotocin (STZ; Sigma, St Louis, MO and treated 16 of the diabetic mice with the RAs, all-trans-retinoic acid (ATRA (seven mice and 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenylcarboxamido] benzoic acid (Am580 (nine mice. The other eight mice were used as diabetic controls. We then measured apoptosis in the retina by TdT-dUTP terminal nick-end labeling assay.Results: RAs inhibited the apoptosis of retinal cells in diabetic retinopathy. Many apoptotic cells were observed in retinas of the eight diabetic control mice (mean value and SD: 37.8 ± 6.9, whereas when diabetic mice were treated with RAs, the number of apoptotic cells significantly decreased (mean value and SD: 9.9 ± 6.4 for the seven ATRA-treated diabetic mice and 9.8 ± 5.9 for the nine Am580-treated diabetic mice (p < 0.05.Conclusion: Treatment with RAs decreases apoptosis during the development of diabetic retinopathy.Keywords: retinoic acids, apoptosis, diabetic retinopathy, glial cell line-derived neurotrophic factor

  8. The effect of intravitreal bevacizumab on ocular blood flow in diabetic retinopathy and branch retinal vein occlusion as measured by laser speckle flowgraphy

    Directory of Open Access Journals (Sweden)

    Nitta F

    2014-06-01

    Full Text Available Fumihiko Nitta,1 Hiroshi Kunikata,1,2 Naoko Aizawa,1 Kazuko Omodaka,1 Yukihiro Shiga,1 Masayuki Yasuda,1 Toru Nakazawa1–31Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Japan; 2Department of Retinal Disease Control, Tohoku University Graduate School of Medicine, Sendai, Japan; 3Department of Advanced Ophthalmic Medicine, Tohoku University Graduate School of Medicine, Sendai, JapanBackground: This study evaluated the effect of intravitreal injection of bevacizumab (IVB on macular edema associated with diabetic retinopathy (DME or branch retinal vein occlusion (BRVOME using laser speckle flowgraphy.Methods: A comparative interventional study of 25 eyes from 22 patients with macular edema (DME group: 12 eyes; BRVOME group: 13 eyes who underwent IVB. Mean blur rate (MBR was measured in the retinal artery, retinal vein, optic nerve head (ONH, and choroid before and after IVB. Results: In the BRVOME group, there was no significant change in MBR in the retinal artery, retinal vein or ONH, but choroidal MBR decreased significantly (P=0.04. In the DME group, the MBR in the retinal artery, retinal vein, ONH, and choroid decreased significantly (P=0.02, P=0.04, P<0.001, and P=0.04, respectively. In the DME group, pre-IVB MBR in the ONH was significantly correlated with post-IVB foveal thickness (R= -0.71, P=0.002. There was no such correlation in the BRVOME group in the ONH.Conclusion: IVB had a suppressive effect on circulation in eyes with DME but not in those with BRVOME. This suggests that this noninvasive and objective biomarker may be a useful part of pre-IVB evaluations and decision-making in DME.Keywords: macular edema, mean blur rate, optic nerve head, biomarker, ocular circulation

  9. Epoprostenol sodium for treatment of pulmonary arterial hypertension

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    Saito Y

    2015-05-01

    Full Text Available Yukihiro Saito,1 Kazufumi Nakamura,1 Satoshi Akagi,1 Toshihiro Sarashina,1 Kentaro Ejiri,1 Aya Miura,1 Aiko Ogawa,2 Hiromi Matsubara,2 Hiroshi Ito1 1Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan; 2Division of Cardiology, National Hospital Organization Okayama Medical Center, Okayama, Japan Abstract: The release of endogenous prostacyclin (PGI2 is depressed in patients with pulmonary arterial hypertension (PAH. PGI2 replacement therapy by epoprostenol infusion is one of the best treatments available for PAH. Here, we provide an overview of the current clinical data for epoprostenol. Epoprostenol treatment improves symptoms, exercise capacity, and hemodynamics, and is the only treatment that has been shown to reduce mortality in patients with idiopathic PAH (IPAH in randomized clinical trials. We have reported that high-dose epoprostenol therapy (>40 ng/kg/min also results in marked hemodynamic improvement in some patients with IPAH. High-dose epoprostenol has a pro-apoptotic effect on PAH-PASMCs via the IP receptor and upregulation of Fas ligand (FasL in vitro. However, long-term intravenous administration of epoprostenol is sometimes associated with catheter-related infections and leads to considerable inconvenience for the patient. In the future, the development of new routes of administration or the development of powerful PGI2 analogs, IP-receptor agonists, and gene and cell-based therapy enhancing PGI2 production with new routes of administration is required. Keywords: pulmonary arterial hypertension, prostacyclin, apoptosis

  10. Ultrastructural localization of intravenously injected carbon nanohorns in tumor

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    Matsumura S

    2014-07-01

    Full Text Available Sachiko Matsumura,1 Ryota Yuge,2 Shigeo Sato,3 Akihiro Tomida,3 Toshinari Ichihashi,2 Hiroshi Irie,4 Sumio Iijima,2,5,6 Kiyotaka Shiba,1 Masako Yudasaka6 1Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan; 2Smart Energy Research Laboratories, NEC Corporation, Tsukuba, Japan; 3Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Koto-ku, Tokyo, Japan; 4Teikyo University School of Medicine, Tokyo, Japan; 5Faculty of Science and Technology, Meijo University, Tenpaku, Nagoya, Japan; 6Nanotube Research Center, National Institute of Advanced Industrial Science and Technology, Higashi, Tsukuba, Japan Abstract: Nanocarbons have many potential medical applications. Drug delivery, diagnostic imaging, and photohyperthermia therapy, especially in the treatment of tumors, have attracted interest. For the further advancement of these application studies, the microscopic localization of nanocarbons in tumor tissues and cells is a prerequisite. In this study, carbon nanohorns (CNHs with sizes of about 100 nm were intravenously injected into mice having subcutaneously transplanted tumors, and the CNHs in tumor tissue were observed with optical and electron microscopy. In the tumor tissue, the CNHs were found in macrophages and endothelial cells within the blood vessels. Few CNHs were found in tumor cells or in the region away from blood vessels, suggesting that, under these study conditions, the enhanced permeability of tumor blood vessels was not effective for the movement of CNHs through the vessel walls. The CNHs in normal skin tissue were similarly observed. The extravasation of CNHs was not so obvious in tumor but was easily found in normal skin, which was probably due to their vessel wall structure difference. Proper understanding of the location of CNHs in tissues is helpful in the development of the medical uses of CNHs. Keywords: ultrastructural localization, carbon nanohorn, tumor, in vivo, extravasation

  11. Availability of a remote online hemodynamic monitoring system during treatment in a private dental office for medically high-risk patients

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    Shinya Yamazaki

    2008-09-01

    Full Text Available Shinya Yamazaki, Hiroyoshi Kawaai, Shigeo Sasaki, Kazuhiro Shimamura, Hiroshi Segawa, Takahiro SaitoSpecial Care Department in Dentistry, Ohu University Dental Hospital, Koriyama city, Fukushima prefecture, JapanAbstract: The importance of systemic management to prevent accidents is increasing in dentistry because co-morbid illnesses in an aging society and invasive surgical procedures are increasing. In this prefecture, a new medical system called the remote online hemodynamic monitoring system (ROHMs was started in 2001. Eight private dental offices participated in this trial. When dental practitioners feel the risk of a dental procedure, they can contact via ROHMs to this hospital. Then, the hemodynamic data (blood pressure, heart rate, ECG, SpO2, and RPP of the patient in the clinic can be transmitted here via the internet, and the images and the voice can be transmitted as well. The availability of this system was assessed in 66 patients (98 cases. The most frequent complications were hypertension, heart disease, and diabetes mellitus. Systemic management included monitoring during the dental procedure (71.4%, checking vital signs after an interview (15.3%, and monitoring under sedation (13.3%. There were 35.7% of all cases where an unscheduled procedure was necessary for the systemic management. Based on a questionnaire, the majority of the patients felt relieved and safe. This system creates a situation where a specialist is almost present during the procedure. This system will provide significant assistance for future medical cooperation for risk management.Keywords: online, high-risk patient, dental treatment, medical cooperation, medical accident, risk management

  12. A case of sebaceous adenoma of the eyelid showing excessively rapid growth

    Directory of Open Access Journals (Sweden)

    Takayama K

    2013-04-01

    Full Text Available Kei Takayama,1 Yoshihiko Usui,2 Masataka Ito,3 Hiroshi Goto,2 Masaru Takeuchi1 1Department of Ophthalmology, National Defense Medical College, Tokorozawa, Saitama, Japan; 2Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan; 3Department of Developmental Anatomy and Regenerative Biology, National Defense Medical College, Tokorozawa, Saitama, Japan Background: Sebaceous adenomas are found mainly in elderly individuals and are usually tan, pink, or yellow nodules or papules, usually approximately 5 mm in the largest size. Case report: A 65-year-old man presented with a progressively enlarging exophytic lesion in the right eyelid for 3 months. External examination revealed a yellowish-pink growth measuring 18 × 13 × 14 mm. The lesion surface was covered by palpebral conjunctiva with fine papillary projections, vascularity, crusting, and ulceration. Two weeks later, the growth enlarged to 20 × 14 × 14 mm, and ulceration also expanded. An excisional biopsy with clear resection margins was performed. No malignancy was found in the stump. Histopathologically, the lesion was located principally within the cutaneous compartment and composed of multiple circumscribed sebaceous lobules, separated, and exhibiting no cytologic atypia. Cystic change was not evident, and no infiltrative growth pattern, pagetoid lesions, mitotic figures, and lymphovascular space invasion were observed. The Ki-67 nuclear antigen was detected in 10%–15% of cells located in the basal zone of the nodule. Fluorescence in situ hybridization showed low human epidermal growth factor receptor 2 amplification, suggesting no genetic changes. The clinical findings, lack of infiltrative border, low Ki-67 index, and low proliferative ability support a diagnosis of sebaceous adenoma. Conclusion: Sebaceous adenoma that shows excessively rapid growth due to hyperplasia may appear to be malignant. Histopathology, fluorescence in situ hybridization, and Ki-67 were useful to

  13. Persistent corneal epithelial defect responding to rebamipide ophthalmic solution in a patient with diabetes

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    Hayashi Y

    2016-05-01

    Full Text Available Yusuke Hayashi, Hiroshi Toshida, Yusuke Matsuzaki, Asaki Matsui, Toshihiko Ohta Department of Ophthalmology, Juntendo University Shizuoka Hospital, Izunokuni, Shizuoka, Japan Objective: Rebamipide ophthalmic suspension was developed for the treatment of dry eyes and for other corneal diseases, promoting the secretion of both mucin in tear fluid and membrane-associated mucin, increasing the number of goblet cells, and restoring the barrier function of the corneal epithelium. We report a case of a persistent corneal epithelial defect in a patient with diabetes treated with topical application of rebamipide ophthalmic suspension. Case presentation: A 73-year-old woman had a history of type 2 diabetes for 35 years and nonproliferative diabetic retinopathy for 23 years. She presented to our department with discharge and ophthalmalgia in the left eye. A corneal ulcer was detected, and culture of corneal scrapings was performed, with Staphylococcus aureus and Streptococcus canis being isolated. The infection was treated with levofloxacin eye drops and ofloxacin ophthalmic ointment based on the sensitivity profile of the isolate. However, a corneal epithelial defect persisted for approximately 2 months despite continuing treatment with 0.1% hyaluronic acid ophthalmic suspension and 0.3% ofloxacin eye ointment. Her hemoglobin A1c was 7.3%. The persistent corneal epithelial defect showed improvement at 2 weeks after treatment with rebamipide unit dose 2% ophthalmic suspension, and it did not recur even when vitrectomy was subsequently performed for vitreous hemorrhage due to progression of diabetic retinopathy. Conclusion: This is the first report about efficacy of rebamipide unit dose 2% ophthalmic suspension for presenting persistent corneal epithelial defect in a patient with diabetes. In the present case, the suggested mechanisms are the following: improving the corneal barrier function, stabilization of mucin on the keratoconjunctival epithelium, and

  14. PREFACE The International Conference on Science of Friction 2010 (ICSF2010)

    Science.gov (United States)

    Miura, Kouji; Matsukawa, Hiroshi

    2010-11-01

    The second international conference on science of friction in Japan was held at Ise-Shima, Mie on 13-18 September 2010. The conference focused on the elementary process of friction phenomena from atomic and molecular scale view. Topics covered at the conference were: Superlubricity and friction Electronic and phononic contributions to friction Friction on the atomic and molecular scales van der Waals friction and Casimir force Molecular motor and friction Friction and adhesion in soft matter system Wear and crack on the nanocsale Theoretical studies on the atomic scale friction and energy dissipatin Friction and Chaos Mechanical properties of nanoscale contacts Friction of powder The number of participants in the conference was approximately 85, registered from 8 countries. 40 oral and 16 poster talks were presented at the conference. This volume of Journal of Physics: Conference Series includes 19 papers devoted to the topics of friction. The successful organization of the conference was made possible by the contribution of the members of the organizing Committee. The conference was made possible thanks to the financial support from Aichi University of Education, and moreover thanks to the approval societies of The Physical Society of Japan, The surface Science Society of Japan and The Japanese Society of Tribologists. The details of the conference are available on http://www.science-of-friction.com/2010/. Finally we would like to thank the speakers for the high quality of their talks and all participants for coming to Ise-Shima, Japan and actively contributing to the conference. Kouji Miura and Hiroshi Matsukawa Editors

  15. Effect of aging on oral and swallowing function after meal consumption

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    Hiramatsu T

    2015-01-01

    Full Text Available Tetsuya Hiramatsu,1,2 Hideyuki Kataoka,3 Mari Osaki,4 Hiroshi Hagino3,4 1Department of Speech Pathology and Audiology, Matsue Co-medical College, Matsue, Japan; 2Graduate School of Medical Sciences, Tottori University, 3School of Health Science, Faculty of Medicine, Tottori University, 4Rehabilitation Division, Tottori University Hospital, Yonago, Japan Background/purpose: Dysphagia may worsen due to fatigue of the infrahyoid and suprahyoid muscle groups as a result of repetitive swallowing during a meal. We investigated the hypothesis that meal consumption may reduce tongue strength and endurance in older adults (OAs.Methods: Tongue–palate pressure, oral diadochokinesis, repetitive saliva swallowing, and surface electromyography activity before and after a meal were measured in 23 young adults (YAs and 23 OA volunteers.Results: There was a statistically significant difference in both tongue pressure and the number of voluntary swallows between YAs and OAs. Peak tongue pressure was significantly lower in OAs than YAs both before and after meal consumption. The most notable finding was that the first time interval (the time from test initiation to the beginning of the first swallow was prolonged after meal consumption only in OAs, whereas the first time interval showed no difference between YAs and OAs before meal consumption with reference to the repetitive saliva swallowing test. The initiation of swallowing was prolonged by both meal consumption and aging; there was a significant interaction between these two factors. The number of repetitions of the monosyllable/pa/was statistically similar between YAs and OAs before meal consumption, but it was significantly lower in OAs after meal consumption.Conclusion: Aging leads to declining tongue pressure and motor function of the lips. It is possible that swallowing function declines in older individuals when meal consumption is prolonged, especially at the end of mealtime, as a result of their

  16. WHO: the casualties and compromises of renewal.

    Science.gov (United States)

    Horton, Richard

    2002-05-04

    The World Health Organization is the leading international agency in health. WHO's reputation reached a peak in the 1970s with the then director-general Halfdan Mahler's advocacy of Health for All by the Year 2000 and the successful worldwide eradication of smallpox. The 1980s and 1990s saw WHO lose much of its authority. Too easily, the blame was put on one man-Mahler's successor, Hiroshi Nakajima. In 1998, Gro Harlem Brundtland, Figure 1 a former Prime Minister of Norway, took office and WHO began a period of major strategic and structural reform. Almost 4 years into her first term as director-general, I visited WHO's headquarters in Geneva to learn about Dr Brundtland's successes and failures. Figure 2 The ground rules of my visit were that I could talk with anybody and attend almost any meeting (budget discussions were excluded). I interviewed Dr Brundtland, executive directors, members of the staff association, and directors and project managers of programmes such as StopTB, Roll Back Malaria, HIV-AIDS, violence prevention, polio eradication, essential drugs and medicines, and sustainable development. At senior levels, WHO is confident and clear about its purpose-in a way that matches Mahler's vision and goes beyond it in results. Brundtland told me that her most important achievements were to have "strengthened the credibility of WHO" and to have "raised the awareness of health on to the political and global development agendas". But there is a troubling schism between the aspirations of its leadership and the realities faced by the organisation on the ground. Rapid change during the past 4 years has reinvigorated WHO's mandate, but poor management has created new tensions that the organisation's leadership seems unwilling to address.

  17. Rapid tumor necrosis and massive hemorrhage induced by bevacizumab and paclitaxel combination therapy in a case of advanced breast cancer

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    Ono M

    2013-10-01

    Full Text Available Mayu Ono, Tokiko Ito, Toshiharu Kanai, Koichi Murayama, Hiroshi Koyama, Kazuma Maeno, Yasuhiro Mochizuki, Asumi Iesato, Toru Hanamura, Toshihiro Okada, Takayuki Watanabe, Ken-ichi ItoDivision of Breast and Endocrine Surgery, Department of Surgery (II, Shinshu University School of Medicine, Matsumoto, JapanAbstract: Bevacizumab when combined with chemotherapy exerts significant activity against many solid tumors through tumor angiogenesis inhibition; however, it can induce severe side effects. We report the rare case of a 27-year-old premenopausal woman with locally advanced breast cancer that was marked by rapid tumor necrosis followed by massive hemorrhage shortly after bevacizumab and paclitaxel administration. On the basis of histopathological examination of a biopsy specimen and computed tomography findings, she was diagnosed with stage IV estrogen and progesterone receptor-negative and human epidermal growth factor receptor type 2-positive breast cancer with multiple organ metastases when she had entered gestational week 24. Cyclophosphamide, Adriamycin®, fluorouracil therapy was initiated, but multiple liver metastases continued to progress. A healthy fetus was delivered by induced delivery and trastuzumab-based treatment was initiated. Although the multiple liver metastases were controlled successfully by trastuzumab combined with paclitaxel, the primary tumor continued to expand even after subsequent administration of three other treatment regimens including anti-human epidermal growth factor receptor type 2 agents and cytotoxic drugs. To inhibit primary tumor growth, a combination therapy with paclitaxel and bevacizumab was subsequently initiated. Following therapy initiation, however, the large tumor occupying the patient's entire left breast became necrotic and ulcerated rapidly. Furthermore, massive hemorrhage from the tumor occurred 5 weeks after bevacizumab-based therapy initiation. Although hemostasis was achieved by manual

  18. Fluorescence technique application of X-ray in labeling with Mn, Sr and Cu, of the parasitoid and host: Muscidifuax uniraptor Kogan and Legner, 1970 (Hymenoptera: Pteromalidae) and Musca domestica L., 1758 (Diptera: Muscidae); Aplicacao com tecnica de fluorescencia de raios X na marcacao com Mn, Sr e Cu, do parasitoide e hospedeiro: Muscidifurax uniraptor Kogan and Legner, 1970 (Hymenoptera: Pteromalidae) e Musca domestica L., 1758 (Diptera: Muscidae)

    Energy Technology Data Exchange (ETDEWEB)

    Itepan, Natanael Marcio

    2003-07-01

    The objective of this work was to develop the methodology of the labeling adult of Musca domestica and Muscidifurax uniraptor using the elements Mn, Sr and Cu with the use of x-ray fluorescence. This work was carried out in the Laboratory of Biological Control of House Flies, 'Eduardo Hiroshi Mizumoto', of the 'Entomology, Phytopatology and Zoology Department of the College of Agriculture 'Luiz de Queiroz' ESALQ/USP), and the Division of Methods the Development and Nuclear Analytics Techniques, of CENA/USP, Piracicaba, Sao Paulo, Brazil. The larvae was removed to the labeled diet with increasing level of the elements Mn, Sr and Cu. The levels tested for all element were: 0 (control); 0,25; 0,50; 1,00; 2,00; 4,00; 8,00; 16,00; 32,00 and 64,00 mg/gr of diet. Labeled pupae with 1,00 to 4,00 (Mn) and 1,00 (Sr and Cu) mg/gr of diet were tested for the pupal parasitoid M. uniraptor. The concentration quantity of the chemical elements was realized by the Analytical Technique denominated (EDXRF) energy dispersive X-ray fluorescence. Concentrations of 2,00 (Mn) and 1,00 (Sr) supplemented to the diet of M. domestica were sufficient for the adult insect labeled, however, not affecting its life expectancy. Pupae originated from the larvae of M. domestica treated with dose of 2,00 (Mn) and 1,00 (Sr and Cu) mg supplemented to the diet, and used as hosts of the parasitoid M. uniraptor, affected the viability of the immature phase and did not label the adults. (author)

  19. Treatment of a dislocated lens by transcorneal vitrectomy and bimanual phacoemulsification

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    Watanabe A

    2014-08-01

    Full Text Available Akira Watanabe, Tamaki Gekka, Hiroshi Tsuneoka Department of Ophthalmology, The Jikei University School of Medicine, Tokyo, Japan Background: As a method of treatment for a dropped lens nucleus, which occurred during cataract surgery, the dropped lens nucleus was removed through the corneal wound without using pars plana vitrectomy (PPV. After vitrectomy, the dropped lens nucleus was floated on the perfluorocarbon liquid (PFCL. The floating lens nucleus was then phacoemulsified and aspirated. During surgery, irrigation from the anterior chamber was performed. This method was very effective for treatment of a dropped hard nucleus.Case report: During cataract surgery on the left eye of an 80-year-old woman, a posterior capsule rupture occurred. As a result, the lens nucleus dropped into the vitreous cavity. Irrigation to the anterior chamber was performed, with an anterior chamber maintainer inserted through a newly created side port at the corneal limbus. A vitreous cutter and a light guide were inserted in order to perform vitrectomy through the corneal incisions that were created for the cataract surgery. After vitrectomy, the dropped lens nucleus was floated using PFCL. The floating lens nucleus was removed by a bimanual phacoemulsification technique, with the anterior chamber irrigation continuing. The separation of the irrigation port and the aspiration port allowed for effective treatment of the dropped nucleus that was floating on the PFCL, even using a ­phacoemulsification machine with a peristaltic pump system. Safe and effective vitrectomy, similar to a PPV, could be performed with this method using three corneal ports.Conclusion: This technique may allow safer and more effective treatment for a dropped lens nucleus compared with conventional PPV. With this technique, corneal distortion due to surgical manipulation can lead to reduced visibility of the posterior eye. Keywords: dislocated lens, transcorneal vitrectomy, bimanual

  20. ENDOFEM INTEGRATED METHODOLOGY FOR FATIGUE CRACK GROWTH

    Institute of Scientific and Technical Information of China (English)

    C.F.Lee; L.T.Hsiao

    2002-01-01

    In this paper, the FEM with the incremental endochronic cyclic plasticity (EndoFEM) and the rc controlled node-released strategy are employed to study the fatigue crack opened/closed load (Pop) of A1 2024-T3 CCT specimens provided by Mageed and Pandey under several crack lengths and the constant amplitude with various load ratio (R). After statisfactory results are achieved by comparisons of computed Pop values and cited experimental data, the simulations will be extended to the crack lengths with significant bending effect due to short ligaments or high peak (Pmax) or high positive or very low negative R cyclic loads. Through these simulations, the complete map of Pop/Pmax vs. Kmax and R can be constructed and thereafter its correspondant empirical formulae can be proposed. Using these formulae and selecting the traditional fatigue crack growth parameter ΔKeff, the A1 2024-T3 fatigue crack growth rate da/dN vs. ΔK and R data, provided by Hiroshi and Schijve, can be employed to proposed empirical formulae of da/dN vs. ΔKeff and R. After integration, fatigue-crack-growth length a vs. N curves computed by EndoFEM can be obtained. The results are agreed very well with the existing experimental curves. According to the above procedures of simulation and steps of comparions with experiment, this paper may provides an integrate methodology of numerical simulation in the studies of fatigue crack growth for academic and industrial researches and design analysis.

  1. Influence of container structures and content solutions on dispensing time of ophthalmic solutions

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    Keiji Yoshikawa

    2010-05-01

    Full Text Available Keiji Yoshikawa1, Hiroshi Yamada21Yoshikawa Eye Clinic, Tokyo, Japan; 2Santen Pharmaceutical Co., Ltd., Osaka, JapanPurpose: To investigate the influence of container structures and content solutions on the time of dispensing from eye dropper bottles.Methods: Eye dropper bottle models, solution models (filtrate water/surfactant solution and a dispensing time measuring apparatus were prepared to measure the dispensing time.Results: With filtrate water and pressure thrust load of 0.3 MPa, the dispensing time significantly increased from 1.1 ± 0.5 seconds to 4.6 ± 1.1 seconds depending on the decrease of inner aperture diameters from 0.4 mm to 0.2 mm (P < 0.0001. When using the bottle models with inner aperture diameters of 0.4 mm or larger, the dispensing time became constant. The dispensing time using surfactant solution showed the same tendency as above. When pressure thrust load was large (0.07 MPa, the solution flew out continuously with inner aperture diameters of 0.4 mm or larger and the dispensing time could not be measured. The inner aperture diameter most strongly explained the variation of the dispensing time in both the content solutions in the multiple linear regression analysis (filtrate water: 46%, R2 = 0.462, surfactant solution: 56%, R2 = 0.563.Conclusions: Among content solutions and container structures, the dispensing time was mostly influenced by the diameter of the inner aperture of bottles.Keywords: dispensing time, model eye dropper bottle, model ophthalmic solution, nozzle internal space volume, nozzle inner aperture diameter

  2. Genetic association between G protein-coupled receptor kinase 6/β-arrestin 2 and dopamine supersensitivity psychosis in schizophrenia

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    Oda Y

    2015-07-01

    Full Text Available Yasunori Oda,1 Nobuhisa Kanahara,2 Hiroshi Kimura,1 Hiroyuki Watanabe,2 Kenji Hashimoto,3 Masaomi Iyo1 1Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan; 2Division of Medical Treatment and Rehabilitation, 3Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan Background/aim: Dopamine supersensitivity psychosis (DSP, clinically characterized by unstable and severe psychosis or tardive dyskinesia and often categorized as treatment-resistant schizophrenia, is promoted by long-term antipsychotic treatment. An upregulation of the dopamine D2 receptor caused by antipsychotic(s is involved in the development of DSP. The present study explored the potential roles of G protein-coupled receptor kinase 6 (GRK6 and β-arrestin 2 (ARRB2 that are involved in the trafficking of DRD2 in patients with DSP. Methods: We conducted a genetic association study of GRK6/ARRB2 between the patients with DSP episodes [DSP(+ group: N=108] and the patients without DSP(- episodes [DSP(- group: N=169] from the total group of patients (N=333. Based on the patients’ treatment history, a DSP episode was defined as withdrawal psychosis, developed tolerance to antipsychotic effect, and tardive dyskinesia (the remaining 56 patients were excluded due to insufficient information. Results: The results revealed that none of the allelic or genotyping distributions of five single nucleotide polymorphisms (SNPs of GRK6 and three SNPs of ARRB2 showed any significant difference between the DSP(+ and DSP(- groups. Conclusion: The results suggest that the SNP analyses of these two molecules fail to classify patients into the potential clinical subtype of DSP(+ or DSP(- group. However, since GRK6 and ARRB2 are surely involved in dopamine D2 receptor metabolism, further studies based on prospective observations of the onset of DSP under specific antipsychotic treatments are needed. Keywords: antipsychotic

  3. LD50 and inviably dose of gamma radiation for Musca domestica L., 1758 (diptera: muscidae) pupae aged 1, 2, 3 and 4 days

    Energy Technology Data Exchange (ETDEWEB)

    Itepan, Natanael M., E-mail: nmitepan@ifsp.edu.br [Instituto Federal de Sao Paulo (IFSP), Piracicaba, SP (Brazil); Itepan, Sara E.D.Z., E-mail: sarazenitepan@ig.com.br [Universidade de Sao Paulo (FFCLRP/USP), Ribeirao Preto, SP (Brazil). Faculdade de Filosofia Ciencias e Letras; Arthur, Valter, E-mail: arthur@cena.usp.br [Centro de Energia Nuclear na Agricultura (CENA/USP), Piracicaba, SP (Brazil)

    2013-07-01

    This experiment was carried out in Biological Control of Domestic Fly 'Eduardo Hiroshi Mizumoto' Laboratory at Entomology and Acarology Department (LEA/ESALQ/USP) and in Food Irradiation and Radioentomology Laboratory (LIARE/CENA/USP). The gamma radiation source that was used is a Co-60 irradiator model Gammabeam-650 of the Atomic Energy of Canada Ltd. whose activity in the beginning of the experiments was 9.8x10{sup 13} Bq. (2,644 Ci). The lots of pupae of Musca domestica had been kept in acclimatized room with 25 ± 2 deg C of temperature and 70 ± 5% of relative humidity, until reaching the desired ages. Lots of pupae of M. domestica that had been used, gotten by the flotation process. They had been irradiated with the ages of 1, 2, 3 and 4 days. The used doses for 1 day pupae was 0 (control) 2.5, 5, 7.5, 10, 12.5, 15, 17.5 20, 22.5, 25, 27.5 and 30 Gy; for 2 days pupae: 0 (control), 20, 40, 60, 80, 100, 120, 140, 160, 180, 200, 220, 240, 260, 280 and 300 Gy; for 3 days pupae: 0 (control), 0, 40, 80, 120, 160, 200, 240, 280, 320 and 360 Gy; and for 4 days pupae: 0 (control), 40; 80; 120; 160, 200, 240, 280, 320, 360, 400 480 and 520 Gy. The dose rate was about 1,500Gy/hr. At these age intervals, the dose to prevent adult emergence was 25, 220, 360 and 520 Gy and the LD50 was 14.28, 128.04, 243.09 e 353.57 Gy, respectively. (author)

  4. Investigation of the association between the GLC3A locus and normal tension glaucoma in Japanese patients by microsatellite analysis

    Directory of Open Access Journals (Sweden)

    M Kamio

    2009-01-01

    Full Text Available M Kamio1*, A Meguro1*, M Ota2, N Nomura1, K Kashiwagi3, F Mabuchi3, H Iijima3, K Kawase4, T Yamamoto4, M Nakamura5, A Negi5, T Sagara6, T Nishida6, M Inatani7, H Tanihara7, M Aihara8, M Araie8, T Fukuchi9, H Abe9, T Higashide10, K Sugiyama10, T Kanamoto11, Y Kiuchi11, A Iwase12, S Ohno13, H Inoko14, N Mizuki11Department of Ophthalmology, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan; 2Department of Legal Medicine, Shinshu University School of Medicine, Matsumoto, Nagano, Japan; 3Department of Ophthalmology, University of Yamanashi, Faculty of Medicine, Yamanashi, Japan; 4Department of Ophthalmology, Gifu University Graduate School of Medicine, Gifu, Japan; 5Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan; 6Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan; 7Department of Ophthalmology and Visual Science, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan; 8Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo, Japan; 9Division of Ophthalmology and Visual Science, Graduated School of Medical and Dental Sciences, Niigata University, Niigata, Japan; 10Department of Ophthalmology and Visual Science, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan; 11Department of Ophthalmology and Visual Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan; 12Department of Ophthalmology, Tajimi Municipal Hospital, Tajimi, Gifu, Japan; 13Department of Ophthalmology, Hokkaido University School of Medicine, Sapporo, Japan; 14Department of Genetic Information, Division of Molecular Life Science, Tokai University School of Medicine, Isehara, Kanagawa, Japan; *These authors contributed equally to this reportPurpose: To investigate whether the GLC3A locus harboring the CYP1B1 gene is associated with normal tension glaucoma

  5. Analysis of major virulence and antibiotics resistance in Vibrio parahaemolyticus isolates from environment and seafood in Ningbo of Zhejiang Province%宁波地区海产品及环境中副溶血弧菌主要毒力及耐药性分析

    Institute of Scientific and Technical Information of China (English)

    吴蓓蓓; 俞盈; 金培婕; 方维焕

    2011-01-01

    Major virulence and antibiotics resistance were investigated in V.parahaemolyticus isolates from Ningbo area.The gene tdh existed in 2.2% from 90 isolates was in accordance with result of Kanagawa phenomenon.There was no vscC2 gene among the tdh-positive isolates, and among one of the type three secretion system 2 (T3SS2) gene family.The genes trh,ureC and Vp 1408 existed in 20.0 % , 12.2 % and 17.8 % respectively from 90 isolates.Urease phenotype showed negative of 11 trh-and-ureC-positive isolates, and non trh or ureC was identified in 2 urease positive isolates.The result of Antimicrobial Susceptibilities showed that all the isolates were sensitive to fluoroquinolones, chloramphenicol and tetracyclines.Over 72% of isolates were resistant to penicillins, sulfonamides, streptomycin and Kanamycin.Of 82 % of all tested strains were multi-drug resistance to over 6 kinds of drugs, with the most to 10 kinds of drugs.The resistant genes of tetB, bla TEM, sul2 and strB existed in 0%, 91.7%, 16.7% and 43.3% respectively from isolates.Representative V.parahaemolyticus isolates could be used for further investigation into their pathogenicity and mechanism of drug resistance, functional genomics and molecular evolution, and could provide guide to clinical treatment for food poisoning of Vibrio parahaemolyticus.%目的 了解浙江省宁波地区海产品和环境中副溶血弧菌主要毒力和耐药性.方法 采用生化反应、抗菌药物敏感性试验及PCR方法对分离的宁波地方副溶血弧菌进行毒力及耐药性测定.结果 90株分离株中,耐热直接溶血素基因(tdh)阳性率为2.2%,与神奈川溶血表型(KP,Kanagawa phenomenon)一致,但在tdh+和KP阳性的分离株中未检测到Ⅲ型分泌系统2(T3SS2);trh与ureC基因携带率分别为20.0%和12.2%,而在11株trh+-ureC+菌株中未显示尿素酶表型阳性,2株尿素酶阳性的菌株未携trh或ureC基因;Ⅵ型分泌系统的携带率为17.8%.所有的分离株

  6. Monitoring Lead (Pb) Pollution and Identifying Pb Pollution Sources in Japan Using Stable Pb Isotope Analysis with Kidneys of Wild Rats

    Science.gov (United States)

    Nakata, Hokuto; Nakayama, Shouta M. M.; Oroszlany, Balazs; Ikenaka, Yoshinori; Mizukawa, Hazuki; Tanaka, Kazuyuki; Harunari, Tsunehito; Tanikawa, Tsutomu; Darwish, Wageh Sobhy; Yohannes, Yared B.; Saengtienchai, Aksorn; Ishizuka, Mayumi

    2017-01-01

    Although Japan has been considered to have little lead (Pb) pollution in modern times, the actual pollution situation is unclear. The present study aims to investigate the extent of Pb pollution and to identify the pollution sources in Japan using stable Pb isotope analysis with kidneys of wild rats. Wild brown (Rattus norvegicus, n = 43) and black (R. rattus, n = 98) rats were trapped from various sites in Japan. Mean Pb concentrations in the kidneys of rats from Okinawa (15.58 mg/kg, dry weight), Aichi (10.83), Niigata (10.62), Fukuoka (8.09), Ibaraki (5.06), Kyoto (4.58), Osaka (4.57), Kanagawa (3.42), and Tokyo (3.40) were above the threshold (2.50) for histological kidney changes. Similarly, compared with the previous report, it was regarded that even structural and functional kidney damage as well as neurotoxicity have spread among rats in Japan. Additionally, the possibility of human exposure to a high level of Pb was assumed. In regard to stable Pb isotope analysis, distinctive values of stable Pb isotope ratios (Pb-IRs) were detected in some kidney samples with Pb levels above 5.0 mg/kg. This result indicated that composite factors are involved in Pb pollution. However, the identification of a concrete pollution source has not been accomplished due to limited differences among previously reported values of Pb isotope composition in circulating Pb products. Namely, the current study established the limit of Pb isotope analysis for source identification. Further detailed research about monitoring Pb pollution in Japan and the demonstration of a novel method to identify Pb sources are needed. PMID:28075384

  7. Influence of treatment with alendronate on the speed of sound, an ultrasound parameter, of the calcaneus in postmenopausal Japanese women with osteoporosis: a clinical practice-based observational study

    Directory of Open Access Journals (Sweden)

    Iwamoto J

    2012-06-01

    Full Text Available Jun Iwamoto,1 Tetsuya Takada,2 Yoshihiro Sato,3 Hideo Matsumoto11Institute for Integrated Sports Medicine, Keio University School of Medicine, Tokyo, 2Department of Internal Medicine, Hiyoshi Medical Clinic, Kanagawa, 3Department of Neurology, Mitate Hospital, Fukuoka, JapanPurpose: The influence of alendronate (ALN treatment on the quantitative ultrasound parameters of the calcaneus remains to be established in Japanese patients. The aim of the present clinical practice-based observational study was to examine the influence of ALN treatment for 1 year on the speed of sound (SOS of the calcaneus and bone turnover markers in postmenopausal Japanese women with osteoporosis.Patients and methods: Forty-five postmenopausal Japanese women with osteoporosis who had received treatment with ALN for more than 1 year were enrolled in the study. The SOS and bone turnover markers were monitored over 1 year of ALN treatment.Results: The urinary levels of cross-linked N-terminal telopeptides of type I collagen and serum levels of alkaline phosphatase decreased significantly from the baseline values (–44.9% at 3 months and –22.2% at 12 months, respectively. The SOS increased modestly, but significantly, from the baseline value (0.6% at both 6 and 12 months. The percentage decrease in the urinary levels of cross-linked N-terminal telopeptides of type I collagen at 3 months was significantly correlated with the percentage increase in the SOS only at 6 months (correlation coefficient, 0.299.Conclusion: The present study confirmed that ALN treatment suppressed bone turnover, producing a clinically significant increase in the SOS of the calcaneus in postmenopausal Japanese women with osteoporosis.Keywords: postmenopausal osteoporosis, quantitative ultrasound (QUS, SOS, bone turnover, biochemical markers

  8. [Clinical and bacteriological effects of cefetamet pivoxil against community-acquired respiratory tract infections. Part III].

    Science.gov (United States)

    Ishihara, R; Suzuki, Y; Nishinari, C; Ishii, Y; Matsumoto, Y; Kaku, M; Shimada, J

    1999-06-01

    We investigated clinical and bacteriological effects of cefetamet pivoxil (CEMT-PI) on community-acquired respiratory tract infection and obtained the following results: This method of investigation was almost the same to those adopted in 1994 and 1996. 1. 512 cases of respiratory tract infection were treated with CEMT-PI under the same protocol at a total of 53 institutions in Tokyo, Kanagawa, Saitama, Chiba and Yamanashi prefectures from January, 1, 1998 over March, 31, 1998. Outpatients accounted for 99.7% of all subjects. Diagnoses given to these patients included pharyngolaryngitis (51.4%), tonsillitis (37.7%), and acute bronchitis (10.1%). 2. For the bacteriological study, a manual detailing the method of collecting specimens, storage and transport was distributed to the above-mentioned institutions. The isolation and identification of suspected causative bacteria, determination of minimum inhibitory concentrations (MICs), and investigation of beta-lactamase production were conducted all together at Section of Studies, Tokyo Clinical Research Center. Suspected causative bacteria were detected in 144 (37.2%) out of 387 cases that were the analytical subjects of the clinical efficacy. The major bacteria identified were 32 strains of Streptococcus pyogenes and 19 strains of Haemophilus influenzae. The clinical efficacy (the ratio of improvement) of CEMT by suspected causative bacterium was 84.4% against CEMT-indicated organisms and 81.2% against CEMT-non-indicated organisms. 3. We investigated clinical efficacy rates (the ratio of "markedly improved" + "improved") by disease. The improvement rate was 78.4% in pharyngolaryngitis, 87.0% in tonsillitis, and 79.5% in acute bronchitis. The clinical efficacy rate was an average of 81.9% in all CEMT-PI indicated diseases.

  9. End-of-life care bonus promoting end-of-life care in nursing homes: An 11-year retrospective longitudinal prefecture-wide study in Japan.

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    Nishiguchi, Sho; Sugaya, Nagisa; Sakamaki, Kentaro; Mizushima, Shunsaku

    2017-03-22

    The end-of-life (EOL) care bonus introduced by the Japanese government works as a financial incentive and framework of quality preservation, including advance care planning, for EOL care among nursing home residents. This study aims to clarify the effects of the EOL care bonus in promoting EOL care in nursing homes. A longitudinal observational study using a questionnaire was conducted. We invited 378 nursing homes in Kanagawa prefecture in Japan, a region with a rapidly aging population, to participate in the study. The outcome was the number of residents dying in nursing homes from 2004 to 2014. In a linear mixed model, fixed-effect factors included year established, unit care, regional elderly population rate and hospital beds, adjacent affiliated hospital, full-time physician on site, physician's support during off-time, basic EOL care policy, usage of the EOL care bonus, EOL care conference, and staff experience of EOL care. A total of 237 nursing home facilities responded (62.7%). The linear mixed model showed that the availability of the EOL care bonus (coefficient 3.1, 95 % CI 0.67-5.51, p = 0.012) and years of usage of the EOL care bonus (p homes. Our analysis revealed that the EOL care bonus has the potential to increase the number of residents receiving EOL care in nursing homes over several years. EOL care conferences, physician support for emergency care during off-time, and the presence of an adjacent affiliated hospital may also increase the number of residents receiving EOL care in nursing homes. These results suggest that a government financial incentive may contribute to effective EOL care among nursing home residents in other developed countries with rapidly aging populations.

  10. Influence of serotonergic/noradrenergic gene polymorphisms on nausea and sweating induced by milnacipran in the treatment of depression

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    Hisashi Higuchi, Hitoshi Takahashi

    2009-07-01

    Full Text Available Hisashi Higuchi1, Hitoshi Takahashi2, Mitsuhiro Kamata3, Keizo Yoshida41Department of Psychiatry, St. Marianna University, School of Medicine, Kanagawa, Japan; 2Department of Psychiatry, Tokyo Women’s Medical University, School of Medicine, Tokyo, Japan; 3Department of Psychiatry, Yuri-Kumiai General Hospital, Yuri-Honjo, Akita, Japan; 4Department of Psychiatry, Nagoya University School of Medicine, Aichi, JapanAbstract: The present study was conducted to find out the predictors of side effects such as nausea and excessive sweating induced by milnacipran, a serotonin/norepinephrine reuptake inhibitor. Both clinical characteristics prior to the treatment and gene polymorphisms such as serotonin transporter (5-HTT gene-linked polymorphic region (5-HTTLPR, a variable number of tandem repeats in the second intron of the 5-HTT gene (5-HTTVNTR, 5-HT2A receptor gene (5-HT2A G-1438A, a TPH gene polymorphism in intron 7 (TPH A218C, norepinephrine transporter (NET gene polymorphism in the promoter region (NET T-182C and in the exon 9 (NET G1287A, a variable number of tandem repeats in the promoter region of monoamine oxidase A, were items to be assessed in this study. Ninety-six patients with major depressive disorder were treated with milnacipran. Side effects were assessed at 1, 2, 4, and 6 weeks of treatment with Udvalg for Kliniske Undersogelser side effects scale. The results showed that no gene polymorphisms included in this study affected the susceptibility of nausea and excessive sweating induced by milnacipran. Patients with older age are more likely to develop excessive sweating than others. The major limitation of this study is a small sample size. Further studies with larger populations and more kinds of gene polymorphisms should be needed to see if specific gene polymorphisms determine the susceptibility of side effects induced by milnacipran. Keywords: milnacipran, nausea, excessive sweating, gene polymorphisms

  11. [Quantitative analysis of the demand for emergency medicine in Yokohama City, Japan].

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    Ohshige, Kenji; Ii, Masako; Nawata, Kazumitsu; Mizushima, Shunsaku; Tochikubo, Osamu

    2003-09-01

    We analyzed regional characteristics that potentially might affect regional demand for emergency medicine in Yokohama city and projected the number of future ambulance users. The number of patients transported by ambulance was regarded as an index of the demand for emergency medicine. Various factors that may affect regional demand for emergency medicine were used as dependent variables in multiple regression analysis. The future population was estimated by the cohort change rate method based on the 1995 and 2000 censuses. Data pertaining to ambulance use were obtained from the Annual Fire Fighting Bulletin, Yokohama. Data pertaining to regional factors were obtained from the Annual Health Statistics Report, Yokohama; the Annual Health Statistics Report, Kanagawa; and the Statistics Report, Yokohama. Statistically significant relations were observed between ambulance use per 1000 population and particular regional characteristics, i.e. the proportion of persons undergoing health examinations conducted by public health centers, the number of educational health promotion programs managed by the public sector, the proportion of persons in receipt of livelihood protection, the proportions of roads and commercial areas in each district in relation to the total area, the mean land price, the age-adjusted mortality rate, and the proportion of persons aged 65 years or over. The demand for emergency medicine in Yokohama city was predicted to increase dramatically as the population ages. The number of patients transported by ambulance, which was 121,606 in 2000, was projected to exceed 250,000 in 2030 and to approximate 300,000 in 2050. The demand for emergency medicine will increase dramatically in Yokohama city as the society ages, Regional emergency medical systems should be improved accordingly.

  12. Regional outbreak of CTX-M-2 β-lactamase-producing Proteus mirabilis in Japan.

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    Nakano, Ryuichi; Nakano, Akiyo; Abe, Michiko; Inoue, Matsuhisa; Okamoto, Ryoichi

    2012-12-01

    Proteus mirabilis is a common cause of urinary tract infection. Wild-type P. mirabilis strains are usually susceptible to penicillins and cephalosporins, but occurrences of P. mirabilis producing extended-spectrum β-lactamases (ESBLs) have been recently reported. Here, we surveyed the prevalence of cefotaxime resistance among P. mirabilis strains at seven different hospitals in Kanagawa Prefecture, Japan, and investigated their molecular epidemiology to explain the mechanism of their spread. The prevalence of cefotaxime resistance among P. mirabilis increased annually, from 10.1 % in 1998 to 23.1 % in 2003, and increased drastically in 2004, exceeding 40 %. We collected 105 consecutive and non-duplicate cefotaxime-resistant P. mirabilis isolates (MIC 16 to >256 µg ml(-1)) from these hospitals from June 2004 to May 2005 and characterized their profile. PCR and sequence analysis revealed that all resistant strains produced exclusively CTX-M-2 β-lactamase. PFGE analysis identified 47 banding patterns with 83 % or greater similarity. These results indicated that a regional outbreak of P. mirabilis producing CTX-M-2 β-lactamase has occurred in Japan and suggest that the epidemic spread occurred within and across hospitals and communities by extended clonal strains. Plasmid analysis revealed that 44.8 % of plasmids harboured by bla(CTX-M-2) isolates had common profiles, encoding ISEcp1, IS26 and Int1, and belonged to incompatibility group T. Spread of the resistant isolates in Japan resulted from dissemination of narrow-host-range plasmids of the IncT group encoding bla(CTX-M-2). These findings indicate the rapidly developing problem of treating the species to prevent dissemination of ESBL producers.

  13. Sympathetic ophthalmia after 23-gauge transconjunctival sutureless vitrectomy

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    Masatoshi Haruta

    2010-11-01

    Full Text Available Masatoshi Haruta1, Hirokazu Mukuno2, Kazuaki Nishijima3, Hitoshi Takagi4, Mihori Kita51Department of Ophthalmology, Kurume University School of Medicine, Kurume, Fukuoka, Japan; 2Department of Ophthalmology, Konan Hospital, Kobe, Hyogo, Japan; 3Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Kyoto, Japan; 4Department of Ophthalmology, St Marianna University School of Medicine, Kawasaki, Kanagawa, Japan; 5Department of Ophthalmology, Hyogo Prefectural Amagasaki Hospital, Amagasaki, Hyogo, JapanPurpose: We report a case of a sympathetic ophthalmia that occurred after 23-gauge transconjunctival sutureless vitrectomy for a retinal detachment.Case report: A 41-year-old Japanese woman underwent combined phacoemulsification with intraocular lens implantation and 23-gauge transconjunctival sutureless vitrectomy for a rhegmatogenous retinal detachment in the right eye. Endolaser photocoagulation and silicone oil tamponade were used to manage inferior retinal holes. Four weeks after the surgery, she returned with a 5-day history of reduced vision and metamorphopsia in her left eye. Slit-lamp examination showed a shallow anterior chamber in the right eye and moderate anterior uveitis bilaterally. Silicone oil bubbles and pigment dispersion were observed in the subconjunctival space adjacent to the right eye’s superonasal sclerotomy site. Fundus examination showed multifocal serous retinal detachments in both eyes. A diagnosis of sympathetic ophthalmia was made and the patient was treated with intensive topical and systemic steroids. The subretinal fluid cleared in both eyes following treatment. Twelve months after the onset of inflammation, the patient’s condition was stable on a combination of oral cyclosporine and topical steroids. Sunset glow retinal changes remain, but there has been no evidence of recurrent inflammation.Conclusion: Sympathetic ophthalmia can develop after 23-gauge

  14. Effects of a single bout of walking on psychophysiologic responses and executive function in elderly adults: a pilot study

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    Hatta A

    2013-07-01

    Full Text Available Arihiro Hatta,1 Yoshiaki Nishihira,2 Takuro Higashiura3 1Department of Health Pharmacy, Yokohama College of Pharmacy, Yokohama, Kanagawa, Japan; 2Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan; 3Department of Law, Faculty of Law, Seiwa University, Kisarazu, Chiba, Japan Background: The purpose of this study was to examine the effects of a single bout of walking on mood, psychophysiologic responses, and executive function in elderly adults. Methods: Twenty healthy, elderly adults (10 women and 10 men; mean age 70.50 ± 3.4 years participated in this study. Mood, as assessed by the Profile of Mood States, and salivary α-amylase activity were examined before and after walking. Executive functions were also evaluated by the Wisconsin Card Sorting Test. Results: Negative feeling scores such as tension-anxiety, anger-hostility, and confusion significantly improved after walking. No significant differences were found for either salivary α-amylase activities or Wisconsin Card Sorting Test scores before and after walking. However, the changes in salivary α-amylase activity before and after walking correlated positively with the number of total errors and perseverative errors of Nelson in the Wisconsin Card Sorting Test. Conclusion: These results suggest that moderate exercise, such as self-paced one-time walking, induces beneficial psychologic effects in elderly adults. Meanwhile, the significant increase in salivary α-amylase activity after walking might temporarily cause deterioration of executive function. Keywords: salivary α-amylase, Profile of Mood States, Wisconsin Card Sorting Test, perseverative error

  15. Clarification of the characteristics of needle-tip movement during vacuum venipuncture to improve safety

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    Fujii C

    2013-07-01

    Full Text Available Chieko FujiiFaculty of Nursing and Medical Care, Keio University, Kanagawa, JapanBackground: Complications resulting from venipuncture include vein and nerve damage, hematoma, and neuropathic pain. Although the basic procedures are understood, few analyses of actual data exist. It is important to improve the safety standards of this technique during venipuncture. This study aimed to obtain data on actual needle movement during vacuum venipuncture in order to develop appropriate educational procedures.Methods: Six experienced nurses were recruited to collect blood samples from 64 subjects. These procedures were recorded using a digital camera. Software was then used to track and analyze motion without the use of a marker in order to maintain the sterility of the needle. Movement along the X- and Y-axes during blood sampling was examined.Results: Approximately 2.5 cm of the needle was inserted into the body, of which 6 mm resulted from advancing or moving the needle following puncture. The mean calculated puncture angle was 15.2°. Given the hazards posed by attaching and removing the blood collection tube, as well as by manipulating the needle to fix its position, the needle became unstable whether it was fixed or not fixed.Conclusion: This study examined venipuncture procedures and showed that the method was influenced by increased needle movement. Focusing on skills for puncturing the skin, inserting the needle into the vein, and changing hands while being conscious of needle-tip stability may be essential for improving the safety of venipuncture.Keywords: blood collection, nerve damage, motion analysis, patient safety, puncture angle, clinical education

  16. Association of microsatellite polymorphisms of the GPDS1 locus with normal tension glaucoma in the Japanese population

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    Kayo Nakamura

    2009-04-01

    Full Text Available Kayo Nakamura1*, Masao Ota2*, Akira Meguro1, et al1Department of Ophthalmology, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan; 2Departmentof Legal Medicine, Shinshu University School of Medicine, Matsumoto, Nagano, JapanBackground: To investigate whether the GPDS1 locus, a potential causative locus of pigment-dispersion syndrome, is associated with normal-tension glaucoma (NTG in Japanese patients. Materials and methods: We used polymerase chain reaction amplification with sequencespecific primers to analyze 20 polymorphic microsatellite markers in and around the GPDS1 locus with an automated DNA analyzer and automated fragment detection by fluorescent-based technology. The DNA samples used for these analyses were obtained from ethnicity- and gendermatched patients, including 141 Japanese patients with NTG and 101 healthy controls. Patients exhibiting a comparatively early onset were selected as this suggests that genetic factors may show stronger involvement.Results: One allele of D7S2462 exhibited a frequency that was significantly decreased in NTG cases compared to controls (P = 0.0013, Pc = 0.019, OR = 0.48, 95% CI = 0.30–0.75. Alleles at another six microsatellite loci were positively or negatively associated with NTG, but these associations did not retain statistical significance after Bonferroni correction (P < 0.05, Pc > 0.05.Conclusion: Our study showed a significant association between the GPDS1 locus and NTG, suggesting that there may be some genetic risk factor(s in the development of NTG.Keywords: microsatellite, normal tension glaucoma, glaucoma-related pigment dispersion syndrome, GPDS1, DPP6

  17. Comparison of Different Recruitment Methods for Sexual and Reproductive Health Research: Social Media–Based Versus Conventional Methods

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    Motoki, Yoko; Taguri, Masataka; Asai-Sato, Mikiko; Enomoto, Takayuki; Wark, John Dennis; Garland, Suzanne Marie

    2017-01-01

    Background Prior research about the sexual and reproductive health of young women has relied mostly on self-reported survey studies. Thus, participant recruitment using Web-based methods can improve sexual and reproductive health research about cervical cancer prevention. In our prior study, we reported that Facebook is a promising way to reach young women for sexual and reproductive health research. However, it remains unknown whether Web-based or other conventional recruitment methods (ie, face-to-face or flyer distribution) yield comparable survey responses from similar participants. Objective We conducted a survey to determine whether there was a difference in the sexual and reproductive health survey responses of young Japanese women based on recruitment methods: social media–based and conventional methods. Methods From July 2012 to March 2013 (9 months), we invited women of ages 16-35 years in Kanagawa, Japan, to complete a Web-based questionnaire. They were recruited through either a social media–based (social networking site, SNS, group) or by conventional methods (conventional group). All participants enrolled were required to fill out and submit their responses through a Web-based questionnaire about their sexual and reproductive health for cervical cancer prevention. Results Of the 243 participants, 52.3% (127/243) were recruited by SNS, whereas 47.7% (116/243) were recruited by conventional methods. We found no differences between recruitment methods in responses to behaviors and attitudes to sexual and reproductive health survey, although more participants from the conventional group (15%, 14/95) chose not to answer the age of first intercourse compared with those from the SNS group (5.2%, 6/116; P=.03). Conclusions No differences were found between recruitment methods in the responses of young Japanese women to a Web–based sexual and reproductive health survey. PMID:28283466

  18. Monitoring Lead (Pb Pollution and Identifying Pb Pollution Sources in Japan Using Stable Pb Isotope Analysis with Kidneys of Wild Rats

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    Hokuto Nakata

    2017-01-01

    Full Text Available Although Japan has been considered to have little lead (Pb pollution in modern times, the actual pollution situation is unclear. The present study aims to investigate the extent of Pb pollution and to identify the pollution sources in Japan using stable Pb isotope analysis with kidneys of wild rats. Wild brown (Rattus norvegicus, n = 43 and black (R. rattus, n = 98 rats were trapped from various sites in Japan. Mean Pb concentrations in the kidneys of rats from Okinawa (15.58 mg/kg, dry weight, Aichi (10.83, Niigata (10.62, Fukuoka (8.09, Ibaraki (5.06, Kyoto (4.58, Osaka (4.57, Kanagawa (3.42, and Tokyo (3.40 were above the threshold (2.50 for histological kidney changes. Similarly, compared with the previous report, it was regarded that even structural and functional kidney damage as well as neurotoxicity have spread among rats in Japan. Additionally, the possibility of human exposure to a high level of Pb was assumed. In regard to stable Pb isotope analysis, distinctive values of stable Pb isotope ratios (Pb-IRs were detected in some kidney samples with Pb levels above 5.0 mg/kg. This result indicated that composite factors are involved in Pb pollution. However, the identification of a concrete pollution source has not been accomplished due to limited differences among previously reported values of Pb isotope composition in circulating Pb products. Namely, the current study established the limit of Pb isotope analysis for source identification. Further detailed research about monitoring Pb pollution in Japan and the demonstration of a novel method to identify Pb sources are needed.

  19. Development of a new JMA flask sampling and trace gas measuring system for observation on a cargo aircraft C-130H

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    K. Tsuboi

    2012-09-01

    Full Text Available We developed and evaluated a flask air sampling system for atmospheric trace gas observation on a cargo C-130H aircraft, as well as an automated analysis system for the flask samples, as part of a new operational monitoring program of the Japan Meteorological Agency (JMA. Air samples were collected during each flight, between Kanagawa Prefecture (near Tokyo and Minamitorishima (an island located nearly 2000 km southeast of Tokyo, from the air-conditioning system on the aircraft. The quality assurance test of the flask sampling air was made by specially coordinated flights at a low altitude of 1000 ft over Minamitorishima and comparing the flask values with those obtained at the surface. Based on our storage tests, the flask samples remained stable until analyses. The concentration measuring system for the flask samples has, in addition to the conventional sensors, two laser-based analyzers using wavelength-scanned cavity ring-down spectroscopy (WS-CRDS and off-axis integrated cavity output spectroscopy (ICOS. Laboratory tests of the measuring system indicated relatively high reproducibility with overall precisions of less than 0.06 ppm for CO2, 0.68 ppb for CH4, 0.36 ppb for CO, and 0.03 ppb for N2O. Inter-comparison experiments for ambient air measurements showed excellent agreements between the laser-based measurement techniques and the conventional methods currently in use. We also found that there are no significant influences of isotope effects for the laser-based analyzers.

  20. Evaluation of a new JMA aircraft flask sampling system and laboratory trace gas analysis system

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    K. Tsuboi

    2013-05-01

    Full Text Available We established and evaluated a flask air sampling system on a cargo C-130H aircraft, as well as a trace gas measurement system for the flask samples, as part of a new operational monitoring program of the Japan Meteorological Agency (JMA. Air samples were collected during each flight, between Kanagawa Prefecture (near Tokyo and Minamitorishima (an island located nearly 2000 km southeast of Tokyo, from the air-conditioning system on the aircraft. Prior to the operational employment of the sampling system, a quality assurance test of the sampled air was made by specially coordinated flights at a low altitude of 1000 ft over Minamitorishima and comparing the flask values with those obtained at the surface. Based on our storage tests, the flask samples remained nearly stable until analyses. The trace gas measurement system has, in addition to the nondispersive infrared (NDIR and vacuum ultraviolet resonance fluorescence (VURF analyzers, two laser-based analyzers using wavelength-scanned cavity ring-down spectroscopy (WS-CRDS and off-axis integrated cavity output spectroscopy (ICOS. Laboratory tests of the laser-based analyzers for measuring flask samples indicated relatively high reproducibility with overall precisions of less than ±0.06 ppm for CO2, ±0.68 ppb for CH4, ±0.36 ppb for CO, and ±0.03 ppb for N2O. Flask air sample measurements, conducted concurrently on different analyzers were compared. These comparisons showed a negligible bias in the averaged measurements between the laser-based measurement techniques and the other methods currently in use. We also estimated that there are no significant isotope effects for CH4, CO and N2O using standard gases with industrial isotopic compositions to calibrate the laser-based analyzers, but CO2 was found to possess isotope effects larger than its analytical precision.

  1. Middle infrared (wavelength range: 8 μm-14 μm) 2-dimensional spectroscopy (total weight with electrical controller: 1.7 kg, total cost: less than 10,000 USD) so-called hyperspectral camera for unmanned air vehicles like drones

    Science.gov (United States)

    Yamamoto, Naoyuki; Saito, Tsubasa; Ogawa, Satoru; Ishimaru, Ichiro

    2016-05-01

    We developed the palm size (optical unit: 73[mm]×102[mm]×66[mm]) and light weight (total weight with electrical controller: 1.7[kg]) middle infrared (wavelength range: 8[μm]-14[μm]) 2-dimensional spectroscopy for UAV (Unmanned Air Vehicle) like drone. And we successfully demonstrated the flights with the developed hyperspectral camera mounted on the multi-copter so-called drone in 15/Sep./2015 at Kagawa prefecture in Japan. We had proposed 2 dimensional imaging type Fourier spectroscopy that was the near-common path temporal phase-shift interferometer. We install the variable phase shifter onto optical Fourier transform plane of infinity corrected imaging optical systems. The variable phase shifter was configured with a movable mirror and a fixed mirror. The movable mirror was actuated by the impact drive piezo-electric device (stroke: 4.5[mm], resolution: 0.01[μm], maker: Technohands Co.,Ltd., type:XDT50-45, price: around 1,000USD). We realized the wavefront division type and near common path interferometry that has strong robustness against mechanical vibrations. Without anti-mechanical vibration systems, the palm-size Fourier spectroscopy was realized. And we were able to utilize the small and low-cost middle infrared camera that was the micro borometer array (un-cooled VOxMicroborometer, pixel array: 336×256, pixel pitch: 17[μm], frame rate 60[Hz], maker: FLIR, type: Quark 336, price: around 5,000USD). And this apparatus was able to be operated by single board computer (Raspberry Pi.). Thus, total cost was less than 10,000 USD. We joined with KAMOME-PJ (Kanagawa Advanced MOdule for Material Evaluation Project) with DRONE FACTORY Corp., KUUSATSU Corp., Fuji Imvac Inc. And we successfully obtained the middle infrared spectroscopic imaging with multi-copter drone.

  2. Dietary compositions and their seasonal shifts in Japanese resident birds, estimated from the analysis of volunteer monitoring data.

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    Tetsuro Yoshikawa

    Full Text Available Determining the composition of a bird's diet and its seasonal shifts are fundamental for understanding the ecology and ecological functions of a species. Various methods have been used to estimate the dietary compositions of birds, which have their own advantages and disadvantages. In this study, we examined the possibility of using long-term volunteer monitoring data as the source of dietary information for 15 resident bird species in Kanagawa Prefecture, Japan. The data were collected from field observations reported by volunteers of regional naturalist groups. Based on these monitoring data, we calculated the monthly dietary composition of each bird species directly, and we also estimated unidentified items within the reported foraging episodes using Bayesian models that contained additional information regarding foraging locations. Next, to examine the validity of the estimated dietary compositions, we compared them with the dietary information for focal birds based on stomach analysis methods, collected from past literatures. The dietary trends estimated from the monitoring data were largely consistent with the general food habits determined from the previous studies of focal birds. Thus, the estimates based on the volunteer monitoring data successfully detected noticeable seasonal shifts in many of the birds from plant materials to animal diets during spring-summer. Comparisons with stomach analysis data supported the qualitative validity of the monitoring-based dietary information and the effectiveness of the Bayesian models for improving the estimates. This comparison suggests that one advantage of using monitoring data is its ability to detect dietary items such as fleshy fruits, flower nectar, and vertebrates. These results emphasize the potential importance of observation data collecting and mining by citizens, especially free descriptive observation data, for use in bird ecology studies.

  3. Local governments and civil society lead breakthrough for tobacco control: lessons from Chandigarh and Chennai.

    Science.gov (United States)

    Kashiwabara, Mina; Arul, Rathinum; Goswami, Hemant; Narain, Jai P; Armada, Francisco

    2011-01-01

    Smoke-free legislation is gaining popularity; however, it must accompany effective implementation to protect people from secondhand smoke (SHS) which causes 600,000 deaths annually. Increasing numbers of smoke-free cities in the world indicate that municipalities have an important role in promoting smoke-free environments. The objectives were to describe the local initiative to promote smoke-free environments and identify the key factors that contributed to the process. Observations were based on a case study on the municipal smoke-free initiatives in Chandigarh and Chennai, India. India adopted the Cigarette and Other Tobacco Products Act in 2003, the first national tobacco control law including smoke-free provisions. In an effort to enforce the Act at the local level, a civil society organization in Chandigarh initiated activities urging the city to support the implementation of the provisions of the Act which led to the initiation of city-wide law enforcement. After the smoke-free declaration of Chandigarh in 2007, Chennai also initiated a smoke-free intervention led by civil society in 2008, following the strategies used in Chandigarh. These experiences resonate with other cases in Asian cities, such as Jakarta, Davao, and Kanagawa as well as cities in other areas of the world including Mexico City, New York City, Mecca and Medina. The cases of Chandigarh and Chennai demonstrate that civil society can make a great contribution to the enforcement of smoke-free laws in cities, and that cities can learn from their peers to protect people from SHS.

  4. Local Governments and civil society lead breakthrough for tobacco control: Lessons from Chandigarh and Chennai

    Directory of Open Access Journals (Sweden)

    Mina Kashiwabara

    2011-01-01

    Full Text Available Smoke-free legislation is gaining popularity; however, it must accompany effective implementation to protect people from secondhand smoke (SHS which causes 600,000 deaths annually. Increasing numbers of smoke-free cities in the world indicate that municipalities have an important role in promoting smoke-free environments. The objectives were to describe the local initiative to promote smoke-free environments and identify the key factors that contributed to the process. Observations were based on a case study on the municipal smoke-free initiatives in Chandigarh and Chennai, India. India adopted the Cigarette and Other Tobacco Products Act in 2003, the first national tobacco control law including smoke-free provisions. In an effort to enforce the Act at the local level, a civil society organization in Chandigarh initiated activities urging the city to support the implementation of the provisions of the Act which led to the initiation of city-wide law enforcement. After the smoke-free declaration of Chandigarh in 2007, Chennai also initiated a smoke-free intervention led by civil society in 2008, following the strategies used in Chandigarh. These experiences resonate with other cases in Asian cities, such as Jakarta, Davao, and Kanagawa as well as cities in other areas of the world including Mexico City, New York City, Mecca and Medina. The cases of Chandigarh and Chennai demonstrate that civil society can make a great contribution to the enforcement of smoke-free laws in cities, and that cities can learn from their peers to protect people from SHS.

  5. Monitoring Lead (Pb) Pollution and Identifying Pb Pollution Sources in Japan Using Stable Pb Isotope Analysis with Kidneys of Wild Rats.

    Science.gov (United States)

    Nakata, Hokuto; Nakayama, Shouta M M; Oroszlany, Balazs; Ikenaka, Yoshinori; Mizukawa, Hazuki; Tanaka, Kazuyuki; Harunari, Tsunehito; Tanikawa, Tsutomu; Darwish, Wageh Sobhy; Yohannes, Yared B; Saengtienchai, Aksorn; Ishizuka, Mayumi

    2017-01-10

    Although Japan has been considered to have little lead (Pb) pollution in modern times, the actual pollution situation is unclear. The present study aims to investigate the extent of Pb pollution and to identify the pollution sources in Japan using stable Pb isotope analysis with kidneys of wild rats. Wild brown (Rattus norvegicus, n = 43) and black (R. rattus, n = 98) rats were trapped from various sites in Japan. Mean Pb concentrations in the kidneys of rats from Okinawa (15.58 mg/kg, dry weight), Aichi (10.83), Niigata (10.62), Fukuoka (8.09), Ibaraki (5.06), Kyoto (4.58), Osaka (4.57), Kanagawa (3.42), and Tokyo (3.40) were above the threshold (2.50) for histological kidney changes. Similarly, compared with the previous report, it was regarded that even structural and functional kidney damage as well as neurotoxicity have spread among rats in Japan. Additionally, the possibility of human exposure to a high level of Pb was assumed. In regard to stable Pb isotope analysis, distinctive values of stable Pb isotope ratios (Pb-IRs) were detected in some kidney samples with Pb levels above 5.0 mg/kg. This result indicated that composite factors are involved in Pb pollution. However, the identification of a concrete pollution source has not been accomplished due to limited differences among previously reported values of Pb isotope composition in circulating Pb products. Namely, the current study established the limit of Pb isotope analysis for source identification. Further detailed research about monitoring Pb pollution in Japan and the demonstration of a novel method to identify Pb sources are needed.

  6. Association of an overlap syndrome of autoimmune hepatitis and primary biliary cirrhosis with cytomegalovirus infection

    Directory of Open Access Journals (Sweden)

    Toyoda-Akui M

    2011-05-01

    Full Text Available Megumi Toyoda-Akui1,4, Hiroaki Yokomori1, Fumihiko Kaneko1,4, Yuki Shimizu1, Hajime Takeuchi1, Kumiko Tahara1, Hide Yoshida1, Hirobumi Kondo1, Tadashi Motoori2, Makoto Ohbu3, Masaya Oda5, Toshifumi Hibi61Department of Internal Medicine, 2Division of Pathology, Kitasato Medical Center Hospital, Kitasato University, Saitama; 3Department of Pathology, School of Allied Health Sciences, Kitasato University, Sagamihara, Kanagawa; 4Department of Internal Medicine, Saitama Social Insurance Hospital, Saitama; 5Organized Center of Clinical Medicine, International University of Health and Welfare, Tokyo; 6Division of Gastroenterology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, JapanAbstract: A 63-year-old woman, who presented with severe jaundice and elevated serum conjugated bilirubin level, denied alcohol and drug use and showed no evidence of viral hepatitis. Based on clinical and laboratory features, she was diagnosed with autoimmune hepatitis with primary biliary cirrhosis. Hematological and immunochemical assays, radiographic imaging, clinical examination, and liver biopsy were conducted. Laboratory results were the following: negative for fluorescence antinuclear antibody, negative for antismooth muscle antibodies but positive for antinuclear antibody (enzyme-linked immunosorbent assay and antimitochondrial M2 antibody, high titers of serum globulin, and positive for cytomegalovirus IgM. Liver biopsy showed submassive lobular necrosis, inflammation with broad areas of parenchymal collapse, and chronic nonsuppurative destructive cholangitis. The patient responded well to corticosteroid therapy. This case might illustrate an association between cytomegalovirus infection and the occurrence of autoimmune hepatitis.Keywords: autoimmune hepatitis, fluorescence antinuclear antibody, enzyme linked immuno sorbent assay, primary biliary cirrhosis, cytomegalovirus infection

  7. A socioeconomic and behavioral survey of patients with difficult-to-control type 2 diabetes mellitus reveals an association between diabetic retinopathy and educational attainment

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    Emoto N

    2016-10-01

    Full Text Available Naoya Emoto,1,2 Fumitaka Okajima,1,2 Hitoshi Sugihara,2 Rei Goto3 1Department of Endocrinology, Nippon Medical School Chiba-Hokusoh Hospital, Chiba, 2Department of Endocrinology, Diabetes and Metabolism, Graduate School of Medicine, Nippon Medical School, Tokyo, 3Graduate School of Business Administration, Keio University, Kanagawa, Japan Background: We have recently reported that the attitude of patients toward risk could be a factor in the progression of diabetic complications. In general, risk preference is closely related to socioeconomic status (SES, which includes factors such as age, sex, income, and educational attainment.Objective: We aimed to determine the effect of SES and behavioral propensity on the progress of diabetic complications in patients with type 2 diabetes mellitus (T2DM.Methods: We conducted a survey of 238 patients with difficult-to-control T2DM treated at a hospital in Japan using a modified behavioral economics questionnaire that included questions related to SES. The patients had been referred by general practitioners or other departments in the hospital because of poor metabolic control or unstable complications.Results: Educational attainment was significantly associated with progression of retinopathy in patients <65 years of age. Educational attainment of a high school diploma (12 years of education or lower was a significant risk factor, but there were no differences among levels of attainment beyond high school (13–16 years or more of education. Behavioral propensities were also weakly associated with complications, but not as much as educational attainment. Personal income level and economic status did not show an association with the retinopathy levels.Conclusion: Lower educational attainment is a strong risk factor for diabetic retinopathy, and it is independent of the economic status. The result suggests that cognitive function may play an important role in the progression of diabetic retinopathy in

  8. Emergence in Japan of an HIV-1 Variant Associated with Transmission among Men Who Have Sex with Men (MSM) in China: First Indication of the International Dissemination of the Chinese MSM Lineage

    Science.gov (United States)

    Kondo, Makiko; Lemey, Philippe; Sano, Takako; Itoda, Ichiro; Yoshimura, Yukihiro; Sagara, Hiroko; Tachikawa, Natsuo; Yamanaka, Ko; Iwamuro, Shinya; Matano, Tetsuro; Imai, Mitsunobu; Kato, Shingo

    2013-01-01

    A survey of HIV-1 strains circulating in the Tokyo-Kanagawa metropolitan area of Japan during 2004 to 2011 (n = 477) identified six Japanese males (patients 1 to 6), who harbored viruses with genome segments derived from a distinct CRF01_AE variant uniquely found among men who have sex with men (MSM) in China (designated CN.MSM.01-1). These six HIV infections were diagnosed in 2010 and 2011 among MSM (3 of 75) and men with unknown risk factors (3 of 63) and differed from the vast majority of HIV infections among MSM in Japan, which are overwhelmingly characterized by subtype B (239 of 246 [97.2%]). Approximately one-third (91 of 239 [38.1%]) of subtype B strains from MSM in Japan belong to a large monophyletic cluster (designated JP.MSM.B-1). In addition, we identified a smaller subtype B cluster (n = 8) (designated JP.MSM.B-2) that also contains strains from two Chinese MSM living in Japan. Interestingly, patients 5 and 6 were found to be coinfected with CRF01_AE (CN.MSM.01-1) and subtype B (JP.MSM.B-2 or JP.MSM.B-1) variants that are unique to the HIV-1 epidemics among MSM in China and Japan, respectively. Our study demonstrates for the first time the effect of the expanding HIV epidemic among MSM in China on transmission in neighboring countries and shows the ongoing mixing of CRF01_AE and subtype B lineages unique to HIV-1 that cocirculate in MSM populations in East Asia. This finding highlights the importance of strengthening epidemiological surveillance in the region and the need for effective measures to limit transmission among MSM in East Asia. PMID:23365432

  9. Factors related to the burnout of Japanese female nurses with children under 3 years old.

    Science.gov (United States)

    Takayama, Yuko; Suzuki, Eiko; Kobiyama, Atsuko; Maruyama, Akiko; Sera, Yoshiko

    2017-07-01

    Burnout is a common feature among healthcare professionals; however, little systematic research exists on burnout among nurses who are raising children. The burnout-related factors among female nurses with children under the age of 3 years were identified in order to ascertain potential burnout prevention methods. In total, 1681 nurses with children who worked at nine city hospitals in Kanagawa Prefecture, Japan, were sent the Maslach Burnout Inventory-Human Services Survey; 1173 nurses responded in June 2014. They were divided according to their sex and children's ages. A data analysis was undertaken for those female nurses with children who were aged under 3 years who provided valid responses (n = 158). A number of factors related to burnout in female nurses with children aged under 3 years was found via a multiple regression analysis: irritation at being unable to attend to their own affairs, over 4-6 h of overtime work per week, having a child aged under 3 years as the first or second child, little sense of work fulfillment, using a childcare facility outside the workplace, dissatisfaction with their salary, feeling ill-qualified as a parent, and a sense of inadequate support. Child care occurs during a limited period and appropriate support is needed. A workplace environment with no overtime work, a childcare facility in the workplace, and mental health support to reduce "feelings of irritation" and "feeling ill-qualified as a parent" could help to prevent burnout in female nurses with toddlers and infants. © 2016 Japan Academy of Nursing Science.

  10. A nationwide survey of ixodid tick species recovered from domestic dogs and cats in Japan in 2011.

    Science.gov (United States)

    Iwakami, Shinya; Ichikawa, Yasuaki; Inokuma, Hisashi

    2014-10-01

    A nationwide survey of ixodid ticks was performed in 2011, during which a total of 4237 and 298 ticks were recovered from 1162 dogs and 136 cats, respectively. Haemaphysalis longicornis was the most frequently found tick species on canine hosts (739 dogs), followed by H. flava (166), Ixodes ovatus (139), and Rhipicephalus sanguineus sensu lato (70). H. hystricis, H. japonica, H. megaspinosa, H. formosensis, H. campanulata, H. ias, I. nipponensis, I. persulcatus, and Amblyomma testudinarium were also recovered. H. longicornis was also the most frequently found species on feline hosts (52 cats), followed by I. ovatus (34), A. testudinarium (19), and H. flava (12). H. hystricis, H. japonica, H. megaspinosa, I. nipponensis, I. persulcatus, I. granulatus and R. sanguineus sensu lato were also recovered from cats. The three major species of ticks found on dogs and cats, H. longicornis, H. flava, and I. ovatus, displayed a wide geographical distribution, with specimens found throughout northern and southern Japan. R. sanguineus sensu lato was primarily recovered in Okinawa, but was also found in Kanagawa, Wakayama, Hiroshima, and Yamaguchi Prefectures. A. testudinarium was mainly distributed throughout western Japan, but small numbers were also recovered from Gumma and Shizuoka Prefectures. H. longicornis was more frequently found on dogs in rural areas than those in urban or suburban areas. Exposure to woodland environments was significantly associated with H. flava and I. ovatus in dogs. Dogs in urban or suburban areas encountered R. sanguineus sensu lato more often than other tick species. Most of the cats surveyed in the present study were from rural areas. In the present study, H. hystricis and R. sanguineus sensu lato were found on cats for the first time in Japan. Copyright © 2014 Elsevier GmbH. All rights reserved.

  11. Introduction to the Proceedings of the 9th ISDH

    Science.gov (United States)

    Bove, V. Michael, Jr.; Riskin, Seth

    2013-02-01

    The Proceedings As co-chairs of the 9th International Symposium on Display Holography, we welcome readers of this collection of papers and posters presented at the event. We hope that both attendees of the event and others pursuing the art, science, and business of holography and 3D imaging will find the authors' contributions of lasting interest and importance. The Event Since its creation at Lake Forest College in 1982 by Professor Tung H Jeong, ISDH has followed a model that differentiates it from other scientific conferences. The 9th ISDH continued this history, fully occupying a floor of the MIT Media Lab for five days. The single-track conference opened with reports on the state of holography in the various nations represented by the attendees, followed by a series of presentations on Education and Holography. One and one-half days of papers on Art and Holography followed, then sessions on Techniques and Materials, Digital Techniques, and Commercial and Applied Holography. A poster session permitted more in-depth discussion between authors and the audience. Two exhibitions of holographic works opened at ISDH: an informal display area at the symposium, and a 15-month-long MIT Museum exhibition, The Jeweled Net: Views of Contemporary Holography. The success of an event of this sort requires the help of many people and organizations. We wish especially to recognize our Honorary Conference Chairs: Tung H Jeong and Joseph W Goodman; our Technical Program Committee: Hans I Bjelkhagen, Frank Fan, Nasser Peyghambarian, and Hiroshi Yoshikawa; and our Arts and Exhibition Committee: Betsy Connors-Chen, Melissa Crenshaw, John Durant, Dieter Jung, Linda Law, Martin Richardson, Jonathan Ross, and Sally Weber. Betsy also coordinated the on-site exhibition. Kristin Hall at the MIT Media Lab made local arrangements, while registration was handled by MIT Conference Services. We also gratefully acknowledge support from Lake Forest College, holographer.org, and authentibrand

  12. Characterization of sputum biomarkers for asthma–COPD overlap syndrome

    Directory of Open Access Journals (Sweden)

    Gao J

    2016-09-01

    Full Text Available Jing Gao,1 Hiroshi Iwamoto,2 Jukka Koskela,3 Harri Alenius,4 Noboru Hattori,2 Nobuoki Kohno,5 Tarja Laitinen,6 Witold Mazur,1 Ville Pulkkinen1 1Heart and Lung Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; 2Department of Molecular and Internal Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan; 3Clinical Research Unit of Pulmonary Diseases and Division of Pulmonology, Heart and Lung Center, University of Helsinki and Helsinki University Hospital, 4Unit of Systems Toxicology, Finnish Institute of Occupational Health, Helsinki, Finland; 5Hiroshima Cosmopolitan University, Hiroshima, Japan; 6Department of Pulmonary Diseases and Clinical Allergology, Turku University Hospital, University of Turku, Turku, Finland Abstract: Asthma–COPD overlap syndrome (ACOS is a commonly encountered chronic airway disease. However, ACOS is still a consensus-based clinical phenotype and the underlying inflammatory mechanisms are inadequately characterized. To clarify the inflammatory mediatypical for ACOS, five biomarkers, namely interleukin (IL-13, myeloperoxidase (MPO, neutrophil gelatinase-associated lipocalin (NGAL, chitinase-like protein (YKL-40, and IL-6, were selected. This study hypothesized that sputum biomarkers relevant for airway inflammation in asthma (IL-13, COPD (MPO, NGAL, or in both asthma and COPD (YKL-40, IL-6 could be used to differentiate ACOS from COPD and asthma. The aim of this study was to characterize the inflammatory profile and improve the recognition of ACOS. Induced sputum levels of IL-13, MPO, NGAL, YKL-40, and IL-6 were measured by enzyme-linked immunosorbent assay/Luminex assay in a Finnish discovery cohort (n=90 of nonsmokers, smokers, and patients with asthma, COPD, and ACOS and validated in a Japanese cohort (n=135. The classification accuracy of potential biomarkers was compared with area under the receiver operating characteristic curves. Only sputum NGAL

  13. Idiopathic horseshoe-like macular tear: a case report

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    Kubota M

    2016-07-01

    Full Text Available Masaomi Kubota,1 Tomohiro Shibata,1 Hisato Gunji,1 Hiroshi Tsuneoka2 1Department of Ophthalmology, The Jikei University School of Medicine Kashiwa Hospital, Chiba, 2Department of Ophthalmology, The Jikei University School of Medicine, Tokyo, Japan Background: Although a few cases with idiopathic horseshoe-like macular tear have been reported, the mechanism remains unknown and a standard treatment has yet to be determined. Objective: To report the outcome for a patient with idiopathic horseshoe-like macular tear who underwent vitreous surgery. Case report: A 65-year-old man with no previous injury or ophthalmic disease presented with abnormal vision in his left eye. Best-corrected visual acuity was 0.8 in the right and 0.3 in the left, and the relative afferent pupillary defect was negative. Ophthalmoscopy revealed a horseshoe-like tear on the temporal side of the macula in the left eye. The tear size was 0.75 disc diameters (DD. Optical coherence tomography showed that the focal retinal detachment reached the fovea. A few days after the first visit, there was no longer adhesion of the flap of the tear to the retina and the tear size had increased to 1.5 DD. The patient underwent vitreous surgery similar to large macular hole surgery, with the tear closure repaired using the inverted internal limiting membrane flap technique with 20% SF6 gas tamponade. Although the tear decreased to 0.5 DD after the surgery, complete closure of the tear was not achieved. Conclusion: While cases with horseshoe-like macular tear following trauma and branch retinal vein occlusion have been reported, to the best of our knowledge, this is the first reported idiopathic case. In the present case, there was expansion of the tear until the patient actually underwent surgery. If vertical vitreous traction indeed plays a role in horseshoe-like macular tears, this will need to be taken into consideration at the time of the vitreous surgery in these types of cases. Keywords

  14. Maximum opening of the mouth by mouth prop during dental procedures increases the risk of upper airway constriction

    Directory of Open Access Journals (Sweden)

    Hiroshi Ito

    2010-05-01

    Full Text Available Hiroshi Ito1, Hiroyoshi Kawaai1, Shinya Yamazaki1, Yosuke Suzuki21Division of Systemic Management, Department of Oral Function, 2Division of Radiology and Diagnosis, Department of Medical Sciences, Ohu University, Post Graduate School of Dentistry, Koriyama City, Fukushima Prefecture, JapanAbstract: From a retrospective evaluation of data on accidents and deaths during dental procedures, it has been shown that several patients who refused dental treatment died of asphyxia during dental procedures. We speculated that forcible maximum opening of the mouth by using a mouth prop triggers this asphyxia by affecting the upper airway. Therefore, we assessed the morphological changes of the upper airway following maximal opening of the mouth. In 13 healthy adult volunteers, the sagittal diameter of the upper airway on lateral cephalogram was measured between the two conditions; closed mouth and maximally open mouth. The dyspnea in each state was evaluated by a visual analog scale. In one subject, a computed tomograph (CT was taken to assess the three-dimensional changes in the upper airway. A significant difference was detected in the mean sagittal diameter of the upper airway following use of the prop (closed mouth: 18.5 ± 3.8 mm, maximally open mouth: 10.4 ± 3.0 mm. All subjects indicated upper airway constriction and significant dyspnea when their mouth was maximally open. Although a CT scan indicated upper airway constriction when the mouth was maximally open, muscular compensation was admitted. Our results further indicate that the maximal opening of the mouth narrows the upper airway diameter and leads to dyspnea. The use of a prop for the patient who has communication problems or poor neuromuscular function can lead to asphyxia. When the prop is used for patient refusal in dentistry, the respiratory condition should be monitored strictly, and it should be kept in mind that the “sniffing position” is effective for avoiding upper airway

  15. Reversible brain atrophy and cognitive impairment in an adolescent Japanese patient with primary adrenal Cushing’s syndrome

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    Ohara N

    2014-09-01

    Full Text Available Nobumasa Ohara,1 Hiroshi Suzuki,1 Akiko Suzuki,1 Masanori Kaneko,1 Masahiro Ishizawa,1 Kazuo Furukawa,1 Takahiro Abe,1 Yasuhiro Matsubayashi,1 Takaho Yamada,1 Osamu Hanyu,1 Takayoshi Shimohata,2 Hirohito Sone1 1Department of Hematology, Endocrinology and Metabolism, Faculty of Medicine, Niigata University, Niigata, Japan; 2Department of Neurology, Brain Research Institute, Niigata University, Niigata, Japan Abstract: Endogenous Cushing’s syndrome is an endocrine disease resulting from chronic exposure to excessive glucocorticoids produced in the adrenal cortex. Although the ultimate outcome remains uncertain, functional and morphological brain changes are not uncommon in patients with this syndrome, and generally persist even after resolution of hypercortisolemia. We present an adolescent patient with Cushing’s syndrome who exhibited cognitive impairment with brain atrophy. A 19-year-old Japanese male visited a local hospital following 5 days of behavioral abnormalities, such as money wasting or nighttime wandering. He had hypertension and a 1-year history of a rounded face. Magnetic resonance imaging (MRI revealed apparently diffuse brain atrophy. Because of high random plasma cortisol levels (28.7 µg/dL at 10 AM, he was referred to our hospital in August 2011. Endocrinological testing showed adrenocorticotropic hormone-independent hypercortisolemia, and abdominal computed tomography demonstrated a 2.7 cm tumor in the left adrenal gland. The patient underwent left adrenalectomy in September 2011, and the diagnosis of cortisol-secreting adenoma was confirmed histologically. His hypertension and Cushingoid features regressed. Behavioral abnormalities were no longer observed, and he was classified as cured of his cognitive disturbance caused by Cushing’s syndrome in February 2012. MRI performed 8 months after surgery revealed reversal of brain atrophy, and his subsequent course has been uneventful. In summary, the young age at onset and the

  16. Objective assessment of skin tightening in Asians using a water-filtered near-infrared (1,000–1,800 nm device with contact-cooling and freezer-stored gel

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    Tanaka Y

    2013-06-01

    Full Text Available Yohei Tanaka,1–3 Yuichiro Tsunemi,2 Makoto Kawashima,2 Naoto Tatewaki,3 Hiroshi Nishida31Clinica Tanaka Plastic, Reconstructive Surgery and Anti-aging Center, Nagano, 2Department of Dermatology, Tokyo Women's Medical University, Tokyo, 3Department of Applied Life Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, JapanBackground: Near-infrared has been shown to penetrate deeper than optical light sources independent of skin color, allowing safer treatment for the Asian skin type. Many studies have indicated the efficacy of various types of devices, but have not included a sufficiently objective evaluation. In this study, we used three-dimensional imaging for objective evaluation of facial skin tightening using a water-filtered near-infrared device.Methods: Twenty Japanese patients were treated with the water-filtered near-infrared (1,000–1,800 nm device using a contact-cooling and nonfreezing gel stored in a freezer. Three-dimensional imaging was performed, and quantitative volume measurements were taken to evaluate the change in post-treatment volume. The patients then provided their subjective assessments.Results: Objective assessments of the treated cheek volume evaluated by a three-dimensional color schematic representation with quantitative volume measurements showed significant improvement 3 months after treatment. The mean volume reduction at the last post-treatment visit was 2.554 ± 0.999 mL. The post-treatment volume was significantly reduced compared with the pretreatment volume in all patients (P < 0.0001. Eighty-five percent of patients reported satisfaction with the improvement of skin laxity, and 80% of patients reported satisfaction with improvement of rhytids, such as the nasolabial folds. Side effects, such as epidermal burns and scar formation, were not observed throughout the study.Conclusion: The advantages of this water-filtered near-infrared treatment are its high efficacy for skin tightening

  17. Prevalence of drug resistance and culture-positive rate among microorganisms isolated from patients with ocular infections over a 4-year period

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    Shimizu Y

    2013-04-01

    Full Text Available Yusuke Shimizu,1 Hiroshi Toshida,1 Rio Honda,1 Asaki Matsui,1 Toshihiko Ohta,1 Yousuke Asada,2 Akira Murakami2 1Department of Ophthalmology, Juntendo University Shizuoka Hospital, Shizuoka, Japan; 2Department of Ophthalmology, Juntendo University School of Medicine, Tokyo, Japan Purpose: To investigate the microbial isolates from patients with ocular infections and the trend in the emergence of levofloxacin-resistant strains over the past four years from 2006 to 2009 retrospectively. Patients and methods: The subjects were 242 patients with ocular infections or traumas treated in our hospital including outpatients, inpatients, and emergency room patients. Most of them needed urgent care presenting with eye complaints, traumas, or decreased vision. Clinical samples were obtained from discharges, corneal, conjunctival tissues or vitreous fluid or aqueous humor, and cultured. Items for assessment included the patient’s age, the diagnosis, the prevalence of isolated bacteria, and the results of susceptibility tests for levofloxacin (LVFX cefamezin (CEZ, gentamicin (GM and vancomycin. This information was obtained from the patients’ medical records. Results: There were 156 male patients and 86 female patients who were aged from 2 months old to 94 years old and mean age was 56.8 ± 24.2 years. Of the 242 patients, 78 (32.2% had positive cultures. The culture-positive rate was significantly higher in male patients than female in total (P = 0.002 and in patients with corneal perforation (P = 0.005. Corneal perforation was the highest culture-positive rate (60.0%, followed by orbital cellulitis (56.5%, blepharitis (50.0%, dacryoadenitis (45.5%, conjunctivitis (38.2%, infectious corneal ulcer (28.5% and endophthalmitis (24.7%. LVFX-resistant strains accounted for 40 out of a total of 122 strains (32.8%, and the minimum inhibitory concentration (MIC was significantly higher in LVFX and GM compared with the other antibiotics. There were no vancomycin

  18. Response of eyes with age-related macular degeneration to anti-VEGF drugs and implications for therapy planning

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    Miyamoto N

    2017-04-01

    Full Text Available Noriko Miyamoto,1,2 Michiko Mandai,1,3 Hiroshi Kojima,1,2 Takanori Kameda,1,2 Masataka Shimozono,1,2 Akihiro Nishida,1,2 Yasuo Kurimoto1,2 1Department of Ophthalmology, Kobe City Medical Center General Hospital, 2Department of Ophthalmology, Institute of Biomedical Research and Innovation, 3Laboratory for Retinal Regeneration, RIKEN Center for Developmental Biology, Kobe, Japan Purpose: To evaluate the response to and dependence on aflibercept or ranibizumab in patients with age-related macular degeneration (AMD.Methods: We retrospectively reviewed AMD patients who received induction therapy with aflibercept or ranibizumab for the following parameters: whether complete resolution of the retinal fluid (“good response” was achieved and whether recurrence was observed within 3 months (“dependent” after the induction treatment. With aflibercept treatment, treatment-naïve eyes with a good response/non-dependence were recommended a pro re nata regimen, and other eyes were recommended a proactive bimonthly regimen, followed by monitoring of visual acuity (VA for 12 months. The measured values of the groups were compared using one-way analysis of variance with Tukey’s test to evaluate the difference between baseline and postinjection VA.Results: Among the treatment-naïve eyes, 76% had a good response to aflibercept and 37% of these were aflibercept-dependent, while 58% had a good response to ranibizumab but 51% of these were ranibizumab-dependent. Among the eyes that converted from ranibizumab treatment, 92% of the good responders to ranibizumab with dependence and 76% of the poor responders on ranibizumab had a good response to aflibercept. With aflibercept treatment, the mean VA of treatment-naïve patients was significantly better than the baseline VA over 12 months (P<0.001, and the VA of the converted group improved significantly with proactive treatment and the improvement was continuously maintained from 6 to 12 months

  19. Indications and postoperative treatment for Ex-PRESS® insertion in Japanese patients with glaucoma: comparison with standard trabeculectomy

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    Kato N

    2015-08-01

    Full Text Available Noriko Kato,1,2 Genichiro Takahashi,1,2 Koichi Kumegawa,1,2 Yoshiaki Kabata,1,2 Hiroshi Tsuneoka1 1Department of Ophthalmology, Jikei University, School of Medicine, 2Katsushika Medical Center, Tokyo, Japan Background: We investigated indications and early postoperative treatment for Ex-PRESS® insertion for glaucoma by comparing postoperative outcomes with those for standard trabeculectomy. Methods: Ex-PRESS insertion was performed in 21 eyes and standard trabeculectomy (TLE in 22 eyes. Mean intraocular pressure (IOP in the 6 months after surgery, success rate for postoperative IOP decline, postoperative complications, postoperative treatment, filtering blebs, and indications were then retrospectively investigated. Results: Mean postoperative IOP did not differ significantly between the groups at any observation time for 6 months after surgery. Further, it did not differ between either the groups of patients with primary open-angle glaucoma (POAG and neovascular glaucoma (NTG, or the patients with primary open-angle glaucoma and NTG in the Ex-PRESS group. Comparison of success rates in reduction of postoperative IOP between the groups under the following four survival conditions showed no significant differences: postoperative IOP <30% of the preoperative IOP, complete success (no additional ophthalmic solution, and qualified success (ophthalmic solution required; 5 mmHg ≤ postoperative IOP ≤21 mmHg, complete success (no additional ophthalmic solution, and qualified success (ophthalmic solution required. With regard to postoperative complications and postoperative treatment, the incidence of hyphema was significantly lower in the Ex-PRESS group, but no other significant intergroup differences were seen. The height of the filtering bleb was lower in the Ex-PRESS group. Conclusion: Postoperative outcomes in the Ex-PRESS and TLE groups were comparable. The incidence of hyphema was significantly lower in the Ex-PRESS group. Ex-PRESS insertion

  20. Comparison of the transport of QX-314 through TRPA1, TRPM8, and TRPV1 channels

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    Nakagawa H

    2013-03-01

    Full Text Available Hiroshi Nakagawa,1 Akio Hiura2 1Dentistry for Persons with Disability, Tokushima University Hospital, Tokushima, Japan; 2Department of Oral Histology, School of Dentistry, University of Tokushima, Tokushima, Japan Background: It has been demonstrated that N-ethyl-lidocaine (QX-314 can target the transient receptor protein vanilloid 1 (TRPV1 nociceptors when coadministered with capsaicin, resulting in a selective block of the nociceptors. Capsaicin is problematic in therapeutic use because it induces firing of nociceptors. The present study aimed to search for substitutes for capsaicin. We also examined the transportability of QX-314 into nociceptive neurons, through the pores of transient receptor potential ankyrin 1 (TRPA1, transient receptor potential melastatin-8 (TRPM8, and TRPV1. Methods: To investigate the effect on TRPA1, injections of a vehicle, allyl isothiocyanate (AITC, QX-314, or AITC/QX-314 were made into the hind paws of rats. The effects of menthol and capsaicin on the opening of TRPM8 and TRPV1 were also examined and compared with the potency of QX-314. To examine inhibition of the antinociceptive effect by capsaicin/QX-314, capsazepine (50 µg/mL; 10 µL was injected 30 minutes prior to capsaicin/QX-314 (10 µL injection. Thermal sensitivity was investigated by the Hargreaves method. 5(6-carboxyfluorescein (FAM-conjugated QX-314 was used as a tracer to examine how many and which kind of dorsal root ganglia accumulate this molecule. QX-314-FAM, capsaicin/QX-314-FAM, AITC/QX-314-FAM, and menthol/QX-314-FAM were injected into the paw. Two weeks after injections, dorsal root ganglia were removed and sectioned with a cryostat. Results: The capsaicin/QX-314 group induced longer withdrawal-response latency at 60 to 300 minutes after injection than the control. Both menthol only and menthol/QX-314 injections showed analgesia 10 to 60 minutes after injection. No significant difference was seen between the capsazepine/capsaicin/QX-314

  1. DFT Thermodynamic Research of the Pyrolysis Mechanism of the Carbon Matrix Precursor Toluene for Carbon Material

    Institute of Scientific and Technical Information of China (English)

    WANG; Hui

    2001-01-01

    [1]Deutsch S. , Keieger K. A. , J. Phy. Chem, 66(19), 1 569(1962)[2]Ooya sugirou, Kobayashi Hiroshi. , Inoue Masahide, et al. , Chem. Technology, 72, 1 300(1969)[3]Ruden A. P. , Vestnik Ko. , Moskov Univ. Ser, 15(5), 69(1969)[4]WANG Yi-Gui, SUN Chang-Jun, DENG Cong-Hao. Science in China (Series B), 28(5), 431(1998)[5]YANG Ming-Li, SUN Ze-Min, YAN Guo-Sen. Chemical Journal of Chinese Universities, 20(3). 450(1999)[6]WANG Hui, ZHAI Gao-hong, YANG Hai-feng, et al. , Chem. J. of Chinese Universities, 22(5), 800(2001)[7]WANG Hui, LUO Rui-Ying, YANG Yan-Qing, et al. , Chinese Journal of Materials Research, 18(4), 10(2000)[8]ZHAI Gao-Hong, WANG Hui, RAN Xing-Quan, et al. , Materials Science and Engineering, (2000)[9]WANG Hui, ZHAI Gao-Hong, RAN Xing-Quan, et al., Chinese Journal of Inorganic Chemistry, 16(6), 879(2000)[10]Ljubisa R. R. , Murthy Karra., Kristina Skokova. , et al. , Carbon. , 36(12), 1 841(1998)[11]Becke D., Density-functional Thermochemistry. Ⅲ. The Role of Exact Exchange, J. Chem. Phys. , 98, 5 648(1993)[12]Bicout D. , Field M. , Quantum Mechanical Simulation Method For Studing Biological System(Les Houches Workship). Springer-Verlag, Berlin, 1 (1995)[13]Frisch M. J.,Trucks G. W. , Schlegel H. B., et al. , Gaussian 98, Revision A. 6, Gaussian, Inc., Pittsburgh PA, 1998[14]Eugene S., Domalski and Elizalzeth D. H. , J. Phys. Chem. , 17, 1 637 (1988)[15]Sharon G. L. , Joel F. L. and Rhoda D. L. , J. Phys. Chem. , 13, 695(1984)[16]Cleveland, David, R. L. (Editor-in-Chief), CRC. Handbook of Chem. and Phy. , (77th Edition), CEC Press INC, 1996-1997:9-27[17]FU Xian-Cai, CHEN Rui-Hua. Physical Chemistry, People Education Press, Beijing, a. 132; b. 191; c. 366(1982)[18]WANG Hui, YANG Hai-fegng, ZHAI Gao-hong, et al. , Acta Chemica Sinca, (1), 17(2001)

  2. The relationship between findings on magnetic resonance imaging and previous history of low back pain

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    Tonosu J

    2016-12-01

    Full Text Available Juichi Tonosu,1 Hiroyuki Oka,2 Ko Matsudaira,2 Akiro Higashikawa,1 Hiroshi Okazaki,1 Sakae Tanaka3 1Department of Orthopedic Surgery, Kanto Rosai Hospital, Kawasaki, 2Department of Medical Research and Management for Musculoskeletal Pain, 22nd Century Medical and Research Center, 3Department of Orthopedic Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan Abstract: The objective of this study was to evaluate the relationship between magnetic resonance imaging (MRI findings and previous low back pain (LBP in participants without current LBP. Current LBP was defined as LBP during the past month. Previous LBP was defined as a history of medical consultation for LBP. Ninety-one participants without current LBP were included. Sagittal T2-weighted MRI was used to assess the intervertebral space from T12/L1 to L5/S1. These images were classified into five grades based on the Pfirrmann grading system. Furthermore, we evaluated the presence of disk bulging, high-intensity zone, and spondylolisthesis. We compared the MRI findings between groups with (27 participants and without (64 participants previous LBP without current LBP. Intraobserver and interobserver kappa values were evaluated. Participants had an average age of 34.9 years; 47 were female and 44 were male; and their average body mass index was 21.8 kg/m2. Compared to the group of participants without previous LBP, the group of participants with previous LBP had a significantly higher incidence of disk degeneration such as a Pfirrmann grade ≥3, disk bulging, and high-intensity zone in the analyses adjusted by age and sex. There were no significant differences in spondylolisthesis between the groups. An odds ratio of >10 was only found for Pfirrmann grade ≥3, ie, a Pfirrmann grade ≥3 was strongly associated with a history of previous LBP in participants without current LBP. Keywords: disk bulging, low back pain, magnetic resonance imaging, MRI, Pfirrmann grading, previous

  3. Ultrasmall cationic superparamagnetic iron oxide nanoparticles as nontoxic and efficient MRI contrast agent and magnetic-targeting tool

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    Uchiyama MK

    2015-07-01

    Full Text Available Mayara Klimuk Uchiyama,1 Sergio Hiroshi Toma,1 Stephen Fernandes de Paula Rodrigues,2 Ana Lucia Borges Shimada,2 Rodrigo Azevedo Loiola,2 Hernán Joel Cervantes Rodríguez,3 Pedro Vitoriano Oliveira,4 Maciel Santos Luz,4 Said Rahnamaye Rabbani,3 Henrique Eisi Toma,1 Sandra Helena Poliselli Farsky,2 Koiti Araki11Laboratory of Supramolecular Chemistry and Nanotechnology, Department of Fundamental Chemistry, Institute of Chemistry, 2Laboratory of Experimental Toxicology, Department of Clinical and Toxicological Analysis, Faculty of Pharmaceutical Sciences, 3Magnetic Resonance Laboratory, Department of General Physics, Institute of Physics, 4Analysis and Research Group in Spectrometry, Department of Fundamental Chemistry, Institute of Chemistry, University of Sao Paulo, Sao Paulo, SP, BrazilAbstract: Fully dispersible, cationic ultrasmall (7 nm diameter superparamagnetic iron oxide nanoparticles, exhibiting high relaxivity (178 mM-1s-1 in 0.47 T and no acute or subchronic toxicity in Wistar rats, were studied and their suitability as contrast agents for magnetic resonance imaging and material for development of new diagnostic and treatment tools demonstrated. After intravenous injection (10 mg/kg body weight, they circulated throughout the vascular system causing no microhemorrhage or thrombus, neither inflammatory processes at the mesentery vascular bed and hepatic sinusoids (leukocyte rolling, adhesion, or migration as evaluated by intravital microscopy, but having been spontaneously concentrated in the liver, spleen, and kidneys, they caused strong negative contrast. The nanoparticles are cleared from kidneys and bladder in few days, whereas the complete elimination from liver and spleen occurred only after 4 weeks. Ex vivo studies demonstrated that cationic ultrasmall superparamagnetic iron oxide nanoparticles caused no effects on hepatic and renal enzymes dosage as well as on leukocyte count. In addition, they were readily concentrated in rat

  4. Experimental Urban Heat Island Research of Four Biggest Polar Cities in Northern Hemisphere

    Science.gov (United States)

    Konstantinov, Pavel; Baklanov, Alexander; Varentsov, Mikhail; Kukanova, Evgenia; Repina, Irina; Shuvalov, Sergey; Samsonov, Timofey

    2014-05-01

    Fairbanks, Alaska// Theor. Appl. Climatol. 1999. V. 64, pp 39-47 2. Ohashi, Yukitaka, Yutaka Genchi, Hiroaki Kondo, Yukihiro Kikegawa, Hiroshi Yoshikado, Yujiro Hirano, 2007: Influence of Air-Conditioning Waste Heat on Air Temperature in Tokyo during Summer: Numerical Experiments Using an Urban Canopy Model Coupled with a Building Energy Model.J. Appl. Meteor. Climatol., 46, 66-81. 3. Oke, Timothy R. Boundary layer climates - 2nd ed. Publisher, London: Routledge. 1987

  5. The dexmedetomidine concentration required after remifentanil anesthesia is three-fold higher than that after fentanyl anesthesia or that for general sedation in the ICU

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    Kunisawa T

    2014-10-01

    Full Text Available Takayuki Kunisawa,1 Kazuhiro Fujimoto,2 Atsushi Kurosawa,2 Michio Nagashima,2 Koji Matsui,2 Dai Hayashi,2 Kunihiko Yamamoto,2 Yuya Goto,2 Hiroaki Akutsu,3 Hiroshi Iwasaki21Surgical Operation Department, Asahikawa Medical University Hospital, 2Department of Anesthesiology and Critical Care Medicine, 3Central Laboratory for Research and Education, Asahikawa Medical University, Asahikawa, Hokkaido, JapanPurpose: The general dexmedetomidine (DEX concentration required for sedation of intensive care unit patients is considered to be approximately 0.7 ng/mL. However, higher DEX concentrations are considered to be required for sedation and/or pain management after major surgery using remifentanil. We determined the DEX concentration required after major surgery by using a target-controlled infusion (TCI system for DEX.Methods: Fourteen patients undergoing surgery for abdominal aortic aneurysms (AAA were randomly, double-blindly assigned to two groups and underwent fentanyl- or remifentanil-based anesthetic management. DEX TCI was started at the time of closing the peritoneum and continued for 12 hours after stopping propofol administration (M0; DEX TCI was adjusted according to the sedation score and complaints of pain. The doses and concentrations of all anesthetics and postoperative conditions were investigated.Results: Throughout the observation period, the predicted plasma concentration of DEX in the fentanyl group was stable at approximately 0.7 ng/mL. In contrast, the predicted plasma concentration of DEX in the remifentanil group rapidly increased and stabilized at approximately 2 ng/mL. The actual DEX concentration at 540 minutes after M0 showed a similar trend (0.54±0.14 [fentanyl] versus 1.57±0.39 ng/mL [remifentanil]. In the remifentanil group, the dopamine dose required and the duration of intubation decreased, and urine output increased; however, no other outcomes improved.Conclusion: The DEX concentration required after AAA surgery with

  6. Target-controlled infusion and population pharmacokinetics of landiolol hydrochloride in patients with peripheral arterial disease

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    Kunisawa T

    2015-01-01

    Full Text Available Takayuki Kunisawa,1 Akio Yamagishi,2 Manabu Suno,3 Susumu Nakade,4 Naoki Honda,4 Atsushi Kurosawa,2 Ami Sugawara,2 Yoshikazu Tasaki,5 Hiroshi Iwasaki2 1Surgical Operation Department, Asahikawa Medical University Hospital, Asahikawa, Japan; 2Department of Anesthesiology and Critical Care Medicine, Asahikawa Medical University, Asahikawa, Japan; 3Department of Oncology Pharmaceutical Care and Sciences, Okayama University, Okayama, Japan; 4Pharmacokinetic Research Laboratories, Ono Pharmaceutical Co., Ltd., Osaka, Japan; 5Department of Hospital Pharmacy and Pharmacology, Asahikawa Medical University, Asahikawa, Japan Purpose: We previously determined the pharmacokinetic (PK parameters of landiolol in healthy male volunteers and gynecological patients. In this study, we determined the PK parameters of landiolol in patients with peripheral arterial disease. Methods: Eight patients scheduled to undergo peripheral arterial surgery were enrolled in the study. After inducing anesthesia, landiolol hydrochloride was administered at target plasma concentrations of 500 and 1,000 ng/mL for 30 minutes each. A total of 112 data points of plasma concentration were collected from the patients and used for the population PK analysis. A population PK model was developed using a nonlinear mixed-effect modeling software program (NONMEM.Results: The patients had markedly decreased heart rates at 2 minutes after initiation of landiolol hydrochloride administration; however, systolic blood pressures were lower than the baseline values at only five time points. The concentration time course of landiolol was best described by a two-compartment model with lag time. The estimates of PK parameters were as follows: total body clearance, 30.7 mL/min/kg; distribution volume of the central compartment, 65.0 mL/kg; intercompartmental clearance, 48.3 mL/min/kg; distribution volume of the peripheral compartment, 54.4 mL/kg; and lag time, 0.633 minutes. The predictive performance of

  7. Presence in a Pocket. Phantasms of Immediacy in Japanese Mobile Telepresence Robotics

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    Timo Kaerlein

    2012-08-01

    Full Text Available The paper addresses prospects of Japanese mobile telepresence robotics where small anthropomorphic devices are designed to act as intermediaries between remote interlocutors. First, an emic perspective of involved scientists and engineers is presented, focusing on example technologies being developed at the Hiroshi Ishiguro Lab in Kyoto (Japan, particularly a „cellphone-type tele-operated android [...] transmitting human presence“ called Elfoid. It represents an attempt to get “behind the veil of the machine” (Sekiguchi/Inami/Tachi 2001, about their RobotPHONE prototype which uses a similar concept in that it is supposed to act as a solid substitute for a dialog partner through evoking a feeling of presence (sonzaikan in Japanese philosophy, the feeling that someone is sharing the same physical space. In such undertakings, specific utopian ideals of communication become apparent. Paradoxically, the high-tech developments aim at constituting seemingly immediate interactions, preferably bypassing any potentially troublesome interface. The existence of a phantasm of immediacy (Bolter/Grusin 2000 can be traced back to decisive moments in media history and belongs to the central promises of new technological interfaces. Interestingly, the engineers’ statements reveal a latent technophobia, an ambition to overcome the limitations of physical devices altogether and to move on to more direct means of communicative exchange (including the mythical dimension of telepathy. Two questions are of particular concern: 1. On what different levels does the notion of immediacy operate? Not only does it refer to a spiritual ideal of unmediated communion, but it also influences practical decisions in interface design. “Natural” and “Tangible” User Interfaces are the result of a practice of disguise in that they mask their factual hypermediacy to allow for a seamless knotting up of real and mediated environments. 2. What is the relationship between

  8. Prefilled syringes and usability of ophthalmic viscosurgical devices

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    Shiba T

    2014-09-01

    Full Text Available Takuya Shiba, Hiroshi TsuneokaDepartment of Ophthalmology, Jikei University School of Medicine, Tokyo, JapanPurpose: To examine the influence of the configuration of prefilled syringes on the usability of ophthalmic viscosurgical devices (OVDs.Setting: Department of Ophthalmology, Jikei University School of Medicine, Tokyo, Japan.Design: Experimental study.Methods: The maximum force needed to extrude the whole OVD (extrusion force was compared among viscous cohesive OVDs (OPEGAN Hi® 0.85 mL and Healon® 0.85 mL and very low viscosity dispersive OVDs (OPEGAN® 0.6 mL and OPEGAN® 1.1 mL. Additionally, to exclude the influence of any differences between syringes of viscous cohesive OVDs on the extrusion force, empty syringes of the same configuration were refilled with the same products. In addition, the syringe inner surface and that of the piston attached to the tip of the plunger were measured.Results: The extrusion force of Healon 0.85 mL (3.28±0.19 kgf was significantly (P<0.01 higher than that of OPEGAN Hi 0.85 mL (2.54±0.23 kgf. The inner syringe chamber for Healon 0.85 mL was vial shaped and had a built-in needle in the Luer tip, which was clearly different from OPEGAN Hi 0.85 mL. There were no significant differences in the extrusion force between refilled syringes. The extrusion force of OPEGAN 1.1 mL (3.44±0.12 kgf was significantly (P<0.01 higher than that of OPEGAN 0.6 mL (1.63±0.06 kgf. The syringe of OPEGAN 1.1 mL was obviously bigger than that of OPEGAN 0.6 mL.Conclusion: It was confirmed that the configuration of the syringes is another determinant of the extrusion force and a factor related to the difference in usability among products that meet the same cohesive class.Keywords: configuration, syringe, extrusion force, viscous cohesive OVDs, low viscosity dispersive OVDs

  9. Five-year outcomes of pars plana vitrectomy for macular edema associated with branch retinal vein occlusion

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    Nishida A

    2017-02-01

    Full Text Available Akihiro Nishida,1,2 Hiroshi Kojima,1,2 Takanori Kameda,1,2 Michiko Mandai,1,3 Yasuo Kurimoto1,2 1Department of Ophthalmology, Kobe City Medical Center General Hospital, 2Department of Ophthalmology, Institute of Biomedical Research and Innovation, 3Laboratory for Retinal Regeneration, RIKEN Center for Developmental Biology, Chuo-ku, Kobe, Hyogo, Japan Purpose: Long-term outcomes of pars plana vitrectomy (PPV for macular edema (ME associated with branch retinal vein occlusion (BRVO have been previously reported, but the studies did not report the number of additional treatments after surgery. During 5 years of follow-up, we therefore investigated the efficacy and safety of PPV for BRVO and evaluated the incidence of additional treatments. Methods: We retrospectively reviewed the medical records of 25 eyes of 24 patients who underwent PPV for ME associated with BRVO and were followed up for at least 5 years. Best-corrected visual acuity was measured, and foveal thickness was assessed by optical coherence tomography. Additional treatments were also investigated. Results: The logarithm of the minimal angle of resolution (logMAR improved from 0.53±0.23 at baseline to 0.16±0.25 at 5 years (P<0.0001. The foveal thickness decreased from 535±222 µm at baseline to 205±143 µm at 5 years (P<0.0001. For the eyes with residual ME, the following additional treatments were performed within 5 years of follow-up: sub-Tenon injection of triamcinolone acetonide in two eyes, intravitreal injection of bevacizumab in three eyes, grid laser photocoagulation in one eye, and direct photocoagulation of macroaneurysm in one eye. Additional surgeries were performed in two eyes: for one eye, phacoemulsification extraction of the ocular lens and intraocular lens implantation were performed because of cataract progression, and for the other eye, additional PPV was done for postoperative retinal detachment. Conclusion: PPV was effective for resolution of ME

  10. Safety comparison of additives in antiglaucoma prostaglandin (PG analog ophthalmic formulations

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    Fukuda M

    2013-03-01

    Full Text Available Masamichi Fukuda, Shinsuke Shibata, Naoko Shibata, Kenta Hagihara, Hiromoto Yaguchi, Hiromi Osada, Nobuo Takahashi, Eri Kubo, Hiroshi SasakiDepartment of Ophthalmology, Kanazawa Medical University, Uchinada, JapanPurpose: To investigate the safety of five types of antiglaucoma prostaglandin analog ophthalmic formulations, and to clarify their differences in accordance with contained additives (preservatives and surface-active agents.Methods: The following five types of ophthalmic solutions and three types of additives were investigated: latanoprost (Xalatan®; latanoprost, tafluprost (Tapros®; tafluprost, bimatoprost (Lumigan®; bimatoprost, travoprost (Travatan®; travoprost, travoprost (Travatan Z®; travoprost-Z, benzalkonium chloride (BAK, polyoxyethylene hardening castor oil 40 (HCO-40, and polysorbate 80 (P-80. These experimental solutions were exposed to the cultured cells of a rabbit-derived corneal cell line for a certain time, and the exposure time causing 50% cell damage (CD50, indicated by the ratio of viable cells to total cells was calculated (in vitro. In addition, corneal resistance (CR was measured and CR ratio (post-treatment CR/pretreatment CR × 100 was calculated (in vivo.Results: CD50 of each ophthalmic solution was the longest with tafluprost, followed by travoprost-Z, bimatoprost, travoprost, and latanoprost. CD50 of 0.005%, 0.01%, and 0.02% BAK was 14.5 minutes, 8.1 minutes, and 4.0 minutes, respectively. The number of viable cells decreased to 60%, 8 minutes after exposure with HCO-40, and 30 minutes after being exposed to P-80. The CR ratio was 81.0% with travoprost and 82.0% with latanoprost, indicating a significant posttreatment reduction of CR (P < 0.05. The CR ratio did not decrease after treatment with tafluprost, travoprost-Z, or bimatoprost. The CR ratio of 0.005%, 0.01%, and 0.02% BAK was 105.0%, 90.5%, and 68.7%, respectively, and that of HCO-40 and P-80 was 108.7% and 114.2%, respectively.Conclusion: BAK

  11. Analyses of electrostatic solitary waves (ESWs) observed by Kaguya near the Moon

    Science.gov (United States)

    Hashimoto, K.; Hashitani, M.; Omura, Y.; Kasahara, Y.; Kojima, H.; Ono, T.; Tsunakawa, H.

    2011-12-01

    In KAGUYA (SELENE) LRS [1], WFC-L [2] observes waveforms of plasma waves in 100Hz-100kHz and a lot of electrostatic solitary waves (ESWs) have been observed. Some results were reported [3]. Although the orthogonal dipole antennas are generally used in the observations, sometimes a pair of monopole antennas were used. We analyze observations mainly by the latter antennas in the present study. Observed waveforms are fitted to ideal ESW waveforms. The waveforms observed by the monopole mode are susceptive to noises and generally they are not similar each other. Since the waveforms observed by the dipole mode are less affected by noises, we re-analyzed the data by fitting these waveforms to the ideal ESW waveforms. The observed ESWs have often components perpendicular to the background magnetic field. This means that the ESW potential structure has two dimensions and they are observed near the generation regions. The propagation velocity, the potential width, the potential depth, etc. of each ESW are also evaluated by comparing the waveforms observed by the monopole antennas. The data fitted to the dipole waveforms are used as references. Acknowledgments: The SELENE project has been organized by the Japan Aerospace Exploration Agency (JAXA). The authors express their thanks to all members of the SELENE project team. References [1] Takayuki Ono, Atsushi Kumamoto, Yasushi Yamaguchi, Atsushi Yamaji, Takao Kobayashi, Yoshiya Kasahara, and Hiroshi Oya, Instrumentation and observation target of the Lunar Radar Sounder (LRS) experiment on-board the SELENE spacecraft, Earth Planets Space, 60, 321-332, 2008. [2] Y. Kasahara, Y. Goto, K. Hashimoto, T. Imachi, A. Kumamoto, T. Ono, and H. Matsumoto, Plasma Wave Observation Using Waveform Capture in the Lunar Radar Sounder on board the SELENE Spacecraft, Earth, Planets and Space, 60, 341-351, 2008. [3] K. Hashimoto, M. Hashitani, Y. Kasahara, Y. Omura, M.N. Nishino, Y. Saito, S. Yokota, T. Ono, H. Tsunakawa, H. Shibuya, M

  12. Analysis of the presence or absence of atrophy of the subgenual and subcallosal cingulate cortices using voxel-based morphometry on MRI is useful to select prescriptions for patients with depressive symptoms

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    Niida A

    2014-12-01

    Full Text Available Akira Niida,1 Richi Niida,2 Hiroshi Matsuda,3 Makoto Motomura,4 Akihiko Uechi5 1Department of Radiology, Nanbu Hospital, Itoman City, Okinawa, Japan; 2Department of Psychiatry, Nanto Clinic, Urasoe City, Okinawa, Japan; 3Integrative Brain Imaging Center, National Center of Neurology and Psychiatry, Kodaira City, Tokyo, Japan; 4Department of Human Sciences, University of the Ryukyus, Nakagami County, Okinawa, Japan; 5Cognitive Neuroscience Research Project, Kansai Gaidai University, Hirakata City, Osaka, Japan Objective: We objectively evaluated the presence or absence of atrophy of the subgenual anterior cingulate cortex (sgACC and the subcallosal anterior cingulate cortex (scACC, using new voxel-based morphometry (VBM software employing Statistical Parametric Mapping software v8 and diffeomorphic anatomic registration through an exponentiated lie algebra. We prepared a database covering young-mature adulthood and investigated the clinical usefulness of the evaluation. Subjects and methods: One hundred seven patients with major depressive disorder (MDD, 74 patients with bipolar disorder (BD, and 240 healthy control subjects underwent 1.5T magnetic resonance imaging scanning. Using new VBM software and databases covering young-mature adults and the elderly, target volumes of interest were set in the sgACC and scACC, four indicators (severity, extent, ratio, and whole-brain extent were determined, and the presence or absence of atrophy of the sgACC and scACC was evaluated on the basis of the indicators. In addition, the relationships between the presence or absence of atrophy of the sgACC and scACC and performance of diagnosing MDD and BD and therapeutic drugs were investigated. Results: It was clarified that the disease is likely to be MDD when atrophy is detected in the sgACC, and likely to be BD when no atrophy is detected in the sgACC but is detected in the scACC. Regarding the relationship with therapeutic drugs, it was clarified that, when

  13. Lung sound analysis helps localize airway inflammation in patients with bronchial asthma

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    Shimoda T

    2017-03-01

    Full Text Available Terufumi Shimoda,1 Yasushi Obase,2 Yukio Nagasaka,3 Hiroshi Nakano,1 Akiko Ishimatsu,1 Reiko Kishikawa,1 Tomoaki Iwanaga1 1Clinical Research Center, Fukuoka National Hospital, Fukuoka, 2Second Department of Internal Medicine, School of Medicine, Nagasaki University, Nagasaki, 3Kyoto Respiratory Center, Otowa Hospital, Kyoto, Japan Purpose: Airway inflammation can be detected by lung sound analysis (LSA at a single point in the posterior lower lung field. We performed LSA at 7 points to examine whether the technique could identify the location of airway inflammation in patients with asthma. Patients and methods: Breath sounds were recorded at 7 points on the body surface of 22 asthmatic subjects. Inspiration sound pressure level (ISPL, expiration sound pressure level (ESPL, and the expiration-to-inspiration sound pressure ratio (E/I were calculated in 6 frequency bands. The data were analyzed for potential correlation with spirometry, airway hyperresponsiveness (PC20, and fractional exhaled nitric oxide (FeNO. Results: The E/I data in the frequency range of 100–400 Hz (E/I low frequency [LF], E/I mid frequency [MF] were better correlated with the spirometry, PC20, and FeNO values than were the ISPL or ESPL data. The left anterior chest and left posterior lower recording positions were associated with the best correlations (forced expiratory volume in 1 second/forced vital capacity: r=–0.55 and r=–0.58; logPC20: r=–0.46 and r=–0.45; and FeNO: r=0.42 and r=0.46, respectively. The majority of asthmatic subjects with FeNO ≥70 ppb exhibited high E/I MF levels in all lung fields (excluding the trachea and V50%pred <80%, suggesting inflammation throughout the airway. Asthmatic subjects with FeNO <70 ppb showed high or low E/I MF levels depending on the recording position, indicating uneven airway inflammation. Conclusion: E/I LF and E/I MF are more useful LSA parameters for evaluating airway inflammation in bronchial asthma; 7-point lung

  14. A single-arm Phase II validation study of preventing oxaliplatin-induced hypersensitivity reactions by dexamethasone: the AVOID trial

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    Yoshida Y

    2015-11-01

    Full Text Available Yoichiro Yoshida,1 Keiji Hirata,2 Hiroshi Matsuoka,3 Shigeyoshi Iwamoto,4 Masahito Kotaka,5 Hideto Fujita,6 Naoya Aisu,1 Seiichiro Hoshino,1 Takeo Kosaka,6 Kotaro Maeda,3 Fumiaki Kiyomi,7 Yuichi Yamashita1 1Department of Gastroenterological Surgery, Fukuoka University Faculty of Medicine, Fukuoka, Japan; 2Department of Surgery, Fukuoka Sanno Hospital, Fukuoka, Japan; 3Department of Surgery, Fujita Health University School of Medicine, Toyoake, Japan; 4Department of Surgery, Kansai Medical University Hirakata Hospital, Osaka, Japan; 5Gastrointestinal Cancer Center, Sano Hospital, Kobe, Japan; 6Department of Surgical Oncology, Kanazawa Medical University, Uchinada, Japan; 7Academia, Industry and Government Collaborative Research Institute of Translational Medicine for Life Innovation, Fukuoka University, Fukuoka, Japan Background: Patients with colorectal cancer treated with oxaliplatin are at risk of hypersensitivity reactions, with the incidence estimated to be 12%–20%. Coinfusion of dexamethasone and oxaliplatin could potentially reduce the incidence of these reactions, but oxaliplatin is reported to be incompatible with alkaline compounds in solution. However, in a previous retrospective study we found that the pH of a solution of dexamethasone and oxaliplatin was less than 7.4, and that hypersensitivity to oxaliplatin could have been prevented by coinfusion of dexamethasone. We aimed to evaluate the effectiveness of coinfusion of dexamethasone and oxaliplatin to prevent oxaliplatin-induced hypersensitivity reactions.Patients and methods: The AVOID trial was a prospective, multicenter, open-label, single-arm Phase II trial conducted from January to September 2013. The study included 73 patients who received capecitabine plus oxaliplatin (XELOX or XELOX plus bevacizumab therapy for colorectal cancer. In all patients, oxaliplatin was administered in combination with dexamethasone. The primary outcome measure was the presence of

  15. Effect of repeated Waon therapy on exercise tolerance and pulmonary function in patients with chronic obstructive pulmonary disease: a pilot controlled clinical trial

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    Kikuchi H

    2013-12-01

    Full Text Available Hiroshi Kikuchi,1,2 Nobuyoshi Shiozawa,1 Shingo Takata,1 Kozo Ashida,1 Fumihiro Mitsunobu11Division of Medicine, Misasa Medical Center, Okayama University Hospital, Misasa, Tottori, Japan; 2Division of Internal Medicine, Takamatsu Hospital KKR, Takamatsu, JapanPurpose: Controlled clinical trials evaluating the efficacy of repeated Waon therapy for patients with chronic obstructive pulmonary disease (COPD have yet to be conducted. The purpose of the present study was to evaluate whether repeated Waon therapy exhibits an adjuvant effect on conventional therapy for COPD patients.Patients and methods: This prospective trial comprised 20 consecutive COPD patients who satisfied the criteria of the Global initiative for chronic Obstructive Lung Disease (GOLD guidelines, stages 1–4. They were assigned to either a Waon or control group. The patients in the Waon group received both repeated Waon therapy and conventional therapy, including medications, such as long-acting inhaled β2 agonists, long-acting anticholinergics and xanthine derivatives, and pulmonary rehabilitation. The Waon therapy consisted of sitting in a 60°C sauna room for 15 minutes, followed by 30 minutes of being warmed with blankets once a day, 5 days a week, for a total of 20 times. The patients in the control group received only conventional therapy. Pulmonary function and the 6-minute walk test were assessed before and at 4 weeks after the program.Results: The change in vital capacity (0.30 ± 0.4 L and in peak expiratory flow (0.48 ± 0.79 L/s in the Waon group was larger than the change in the vital capacity (0.02 ± 0.21 L (P=0.077 and peak expiratory flow (−0.11 ± 0.72 L/s (P=0.095 in the control group. The change in forced expiratory flow after 50% of expired forced vital capacity in the Waon group, 0.08 (0.01–0.212 L/s, was larger than that in the control group, −0.01 (−0.075–0.04 L/s (P=0.019. Significant differences were not observed in the change in any

  16. Preoperative factors predictive of postoperative decimal visual acuity ≥ 1.0 following surgical treatment for idiopathic epiretinal membrane

    Directory of Open Access Journals (Sweden)

    Hiroshi Kunikata

    2011-02-01

    Full Text Available Hiroshi Kunikata1, Toshiaki Abe2, Jiro Kinukawa1, Kohji Nishida1,31Department of Ophthalmology and Visual Science, Tohoku University Graduate School of Medicine, Sendai, Japan; 2Division of Clinical Cell Therapy, Tohoku University Graduate School of Medicine, Sendai, Japan; 3Department of Ophthalmology, Osaka University Medical School, Suita, JapanPurpose: To report the preoperative best-corrected visual acuity (BCVA and foveal thickness (FT values that lead to a postoperative decimal BCVA of ≥ 1.0 after surgical removal of an idiopathic epiretinal membrane (ERM.Methods: This is a retrospective case series of 73 eyes that underwent surgery for removal of an idiopathic ERM. All eyes had been treated by a single surgeon using a 25-gauge transconjunctival sutureless vitrectomy and indocyanine green-assisted internal limiting membrane peel. The BCVA and FT were measured at baseline and 6 months postoperatively.Results: A postoperative decimal BCVA ≥ 1.0 was obtained in eyes with a preoperative decimal BCVA ≥ 0.3 but not in those with a preoperative decimal BCVA ≤ 0.2. The incidence of obtaining a postoperative decimal BCVA ≥ 1.0 was significantly (P = 0.002 higher in eyes with a preoperative decimal BCVA ≥ 0.5 (50% than in eyes with a preoperative decimal BCVA < 0.5 (11%. Additionally, a postoperative decimal BCVA of ≥ 1.0 was obtained in 51% of the eyes that had a preoperative FT < 400 µm, compared with only 21% of eyes with a preoperative FT ≥ 400 µm (P = 0.01. The incidence of obtaining a postoperative decimal BCVA ≥ 1.0 was significantly higher in eyes with preoperative decimal BCVA ≥ 0.5 and FT < 400 µm (60% than in eyes with preoperative decimal BCVA ≥ 0.5 and FT ≥ 400 µm (20%; P = 0.03 or preoperative BCVA < 0.5 and FT ≥ 400 µm (7%; P < 0.001.Conclusions: These findings indicate that eyes with both preoperative BCVA ≥ 0.5 and FT < 400 µm have a significantly better chance of obtaining a postoperative decimal

  17. Effect of calcium channel blockers on incidence of diabetes: a meta-analysis

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    Noto H

    2013-07-01

    Full Text Available Hiroshi Noto,1,2 Atsushi Goto,2 Tetsuro Tsujimoto,1 Mitsuhiko Noda1,2 1Department of Diabetes and Metabolic Medicine, Center Hospital, National Center for Global Health and Medicine, Tokyo, Japan; 2Department of Diabetes Research, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan Aims: Insulin resistance and the progressive loss of ß-cell function are components of the fundamental pathophysiology of type II diabetes. A recent experimental study suggested that calcium channel blockers (CCBs might inhibit ß-cell apoptosis, enhance ß-cell function, and prevent diabetes. The present meta-analysis examined the clinical effect of CCBs on the incidence of diabetes. Methods: MEDLINE, EMBASE, ISI Web of Science, the Cochrane Library, and ClinicalTrials.gov were each searched for relevant articles published up to March 11, 2013. Randomized controlled trials (RCTs with a follow-up period of at least 1-year were included. Identified articles were systematically reviewed, and those with pertinent data were selected for inclusion in a meta-analysis. Results: We included ten RCTs in a meta-analysis. Of the 108,118 people with hypertension and no pre-existing diabetes, 7,073 (6.5% cases of type II diabetes were reported. CCBs were associated with a higher incidence of diabetes than angiotensin-converting enzyme inhibitors (ACEIs or angiotensin-receptor blockers (ARBs; pooled risk ratios [95% confidence intervals]: 1.23 [1.01–1.51] and 1.27 [1.14–1.42], respectively and a lower incidence compared with ß blockers or diuretics (0.83 [0.73–0.94] and 0.82 [0.69–0.98], respectively. The overall risk of diabetes among subjects taking CCBs was not significant (0.99 [0.85–1.15]. Conclusion: The use of CCBs was not significantly associated with incident diabetes compared to other antihypertensive agents: the association with diabetes was lowest for ACEIs and ARBs, followed by CCBs, ß blockers, and

  18. The role of microparticles in chronic obstructive pulmonary disease

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    Takahashi T

    2014-03-01

    Full Text Available Toru Takahashi,1–3 Hiroshi Kubo11Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine, Sendai, Japan; 2Cellular and molecular lung biology research units, Institut de Recherches Cliniques de Montréal (IRCM, Montreal, Quebec, Canada; 3Department of Anesthesiology, Tohoku University Hospital, Sendai, JapanAbstract: Accumulating evidence suggests that cell injury in lung tissues is closely connected to disease progression in chronic obstructive pulmonary disease (COPD. Microparticles (MPs are shed membrane vesicles that are released from platelets, leukocytes, red blood cells, and endothelial cells when these cells are activated or undergo apoptosis under inflammatory conditions. Based on increasing evidence that endothelial injury in the pulmonary capillary vasculature leads to lung destruction, and because cardiovascular diseases are the main cause of death among individuals with COPD, endothelial MPs (EMPs are now receiving attention as potential biomarkers for COPD. There are eight types of EMPs which are defined by the presence of different endothelial markers on the cell membrane: vascular endothelial-cadherin; platelet endothelial cell adhesion molecule; melanoma cell adhesion molecule; E-selectin; CD51; CD105; von Willebrand factor; and CD143 EMPs. Vascular endothelial-cadherin, platelet endothelial cell adhesion molecule, and E-selectin EMPs are increased in patients with stable COPD and are further increased in patients with exacerbated COPD compared to non-COPD patients. In addition, the levels of these three EMPs in patients with stable COPD are significantly correlated with lung destruction and airflow limitation. These results indicate that endothelial injury is closely connected to the pathophysiology of COPD. Interestingly, the variations in the levels of the eight EMP subtypes were not identical with changes in patient condition. Although the clinical significance of

  19. Retinal angiomatous proliferation associated with risk alleles of ARMS2/HTRA1 gene polymorphisms in Japanese patients

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    Ohkuma Y

    2013-12-01

    Full Text Available Yasuhiro Ohkuma,1 Takaaki Hayashi,1 Tsutomu Sakai,1 Akira Watanabe,1 Hisashi Yamada,2 Masakazu Akahori,3 Takeshi Itabashi,3 Takeshi Iwata,3 Toru Noda,4 Hiroshi Tsuneoka11Department of Ophthalmology, 2Department of Molecular Genetics, Institute of DNA Medicine, The Jikei University School of Medicine, 3Division of Molecular and Cellular Biology, National Institute of Sensory Organs, 4Division of Ophthalmology, National Hospital Organization Tokyo Medical Center, Tokyo, JapanBackground: The purpose of this study was to investigate the association between ARMS2/HTRA1, CFH, and C3 gene polymorphisms and retinal angiomatous proliferation (RAP, an infrequent and severe form of exudative age-related macular degeneration, which is characterized by intraretinal neovascularization.Methods: Diagnosis of RAP was based on fundus photographs, images of fluorescein and indocyanine green angiographies, and optical coherence tomography findings. Six single nucleotide polymorphisms (SNPs, A69S (rs10490924 in ARMS2, rs11200638 in HTRA1, I62V (rs800292 in CFH, Y402H (rs1061170 in CFH, R80G (rs2230199 in C3, and rs2241394 in C3, were genotyped in eight Japanese patients with RAP.Results: The two SNPs in the ARMS2/HTRA1 were in complete linkage disequilibrium. The frequency of the risk T allele in ARMS2 (the risk A allele in HTRA1 was 93.8% in the RAP patients. The frequency of homozygosity for the risk genotype TT of ARMS2 (the risk genotype AA of HTRA1 was 87.5%. The frequency of the non-risk allele (A of I62V was 100%. The frequencies of risk alleles of Y402H, R80G, and rs2241394 were 12.5%, 0%, and 18.8%, respectively.Conclusion: Our results suggest that the risk alleles of the ARMS2/HTRA1 SNPs may be associated with development of RAP and play a major role in the pathogenesis of intraretinal angiogenesis.Keywords: age-related macular degeneration, retinal angiomatous proliferation, single nucleotide polymorphisms, ARMS2/HTRA1 genes, components of the complement

  20. Regional differences in hepatitis C treatment with peginterferon and ribavirin in Japan: a retrospective cohort study

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    Ide K

    2016-03-01

    Full Text Available Kazuki Ide,1 Yohei Kawasaki,1 Hiroshi Yamada,1 Naohiko Masaki2 1Department of Drug Evaluation and Informatics, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, 2The Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine, Chiba, JapanPurpose: The aims of this study were to investigate regional differences in hepatitis C virus (HCV infection treatment with peginterferon and ribavirin in Japan and to develop and validate statistical models for analysis of regional differences, using generalized linear mixed models.Methods: Individuals with chronic HCV infection were identified from the Japanese Interferon Database (registered from December 2009 to April 2013. The total sustained virologic response rate and the rate in each prefecture were calculated. In the analysis using generalized linear mixed models, the following four models were constructed: 1 prefecture as a fixed effect, 2 prefecture and other confounding variables as fixed effects, 3 prefecture as a random effect, and 4 prefecture as a random effect and other confounding variables as fixed effects. The quality of the model fit was assessed using the Akaike information criterion and the Bayesian information criterion. All statistical analyses were performed using SAS Version 9.4 for Windows.Results: From 36 prefectures, 16,349 cases were recorded in the study period. Of these, 4,677 were excluded according to certain criteria. The total sustained virologic response rate was 59.9% (range, 43.9%–71.6%. The statistical model including prefecture as a random effect and other confounding variables as fixed effects showed the best fit based on the Akaike information criterion (13,830.92 and Bayesian information criterion (13,845.17.Conclusion: Regional differences may exist in HCV infection treatment in Japan. The model including prefecture as a random effect and other confounding variables as fixed effects was appropriate for

  1. Association of plasma adiponectin levels with cellular hydration state measured using bioelectrical impedance analysis in patients with COPD

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    Yoshikawa T

    2012-08-01

    Full Text Available Takahiro Yoshikawa,1 Hiroshi Kanazawa21Department of Sports Medicine, Osaka City University Graduate School of Medicine, 2Department of Respiratory Medicine, Osaka City University Graduate School of Medicine, Osaka, JapanBackground: It is widely recognized that chronic obstructive pulmonary disease (COPD includes a variety of extra pulmonary complications and comorbidities. Recently, adiponectin was shown to regulate cellular metabolism in humans. Cellular hydration state is affected by a variety of hormonal factors and regulates cellular metabolic state. Therefore, this study was designed to determine whether adiponectin is a possible factor involved in cellular hydration state in COPD.Methods: Thirty patients with COPD and 41 age-matched controls participated in the study. Plasma levels of total and high molecular weight (HMW adiponectin were measured and anthropometry and pulmonary function tests were conducted. Intracellular water (ICW, extracellular water (ECW, and ECW/ICW ratio, which are parameters of cellular hydration state, were measured using bioelectrical impedance analysis.Results: Higher levels of total and HMW adiponectin in plasma were found in patients with COPD compared with levels in controls. A significant inverse correlation was observed between body mass index and plasma levels of total and HMW adiponectin in the control group. However, this significant correlation was not observed in patients with COPD. The plasma levels of total and HMW adiponectin were also not significantly correlated with any pulmonary function parameters in patients with COPD. Regarding the state of cellular hydration, the plasma levels of total adiponectin were inversely correlated with the ECW/ICW ratio and positively with ICW values in patients with COPD. Moreover, closer correlations were found between these parameters and plasma HMW adiponectin levels.Conclusion: The results of the present study suggest a novel association of the plasma

  2. Automated continuous quantitative measurement of proximal airways on dynamic ventilation CT: initial experience using an ex vivo porcine lung phantom

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    Yamashiro T

    2015-09-01

    Full Text Available Tsuneo Yamashiro,1 Maho Tsubakimoto,1 Yukihiro Nagatani,2 Hiroshi Moriya,3 Kotaro Sakuma,3 Shinsuke Tsukagoshi,4 Hiroyasu Inokawa,5 Tatsuya Kimoto,5 Ryuichi Teramoto,6 Sadayuki Murayama1 1Department of Radiology, Graduate School of Medical Science, University of the Ryukyus, Nishihara, Okinawa; 2Department of Radiology, Shiga University of Medical Science, Otsu; 3Department of Radiology, Ohara General Hospital, Fukushima; 4CT Systems Division, 5Center for Medical Research and Development, Toshiba Medical Systems Corporation, Otawara; 6Corporate Manufacturing Engineering Center, Toshiba Corporation, Yokohama, Japan Background: The purpose of this study was to evaluate the feasibility of continuous quantitative measurement of the proximal airways, using dynamic ventilation computed tomography (CT and our research software. Methods: A porcine lung that was removed during meat processing was ventilated inside a chest phantom by a negative pressure cylinder (eight times per minute. This chest phantom with imitated respiratory movement was scanned by a 320-row area-detector CT scanner for approximately 9 seconds as dynamic ventilatory scanning. Obtained volume data were reconstructed every 0.35 seconds (total 8.4 seconds with 24 frames as three-dimensional images and stored in our research software. The software automatically traced a designated airway point in all frames and measured the cross-sectional luminal area and wall area percent (WA%. The cross-sectional luminal area and WA% of the trachea and right main bronchus (RMB were measured for this study. Two radiologists evaluated the traceability of all measurable airway points of the trachea and RMB using a three-point scale. Results: It was judged that the software satisfactorily traced airway points throughout the dynamic ventilation CT (mean score, 2.64 at the trachea and 2.84 at the RMB. From the maximum inspiratory frame to the maximum expiratory frame, the cross-sectional luminal area of

  3. Conjunctival sac bacterial flora isolated prior to cataract surgery

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    Suto C

    2012-01-01

    Full Text Available Chikako Suto1,2, Masahiro Morinaga1,2, Tomoko Yagi1,2, Chieko Tsuji3, Hiroshi Toshida41Department of Ophthalmology, Saiseikai Kurihashi Hospital, Saitama; 2Department of Ophthalmology, Tokyo Women's Medical University, Tokyo; 3Department of Clinical Laboratory, Saiseikai Kurihashi Hospital, Saitama; 4Department of Ophthalmology, Juntendo University Shizuoka Hospital, Izunokuni, Shizuoka, JapanObjective: To determine the trends of conjunctival sac bacterial flora isolated from patients prior to cataract surgery.Subjects and methods: The study comprised 579 patients (579 eyes who underwent cataract surgery. Specimens were collected by lightly rubbing the inferior palpebral conjunctival sac with a sterile cotton swab 2 weeks before surgery, and then cultured for isolation of bacteria and antimicrobial sensitivity testing. The bacterial isolates and percentage of drug-resistant isolates were compared among age groups and according to whether or not patients had diabetes mellitus, hyperlipidemia, dialysis therapy, oral steroid use, dry eye syndrome, or allergic conjunctivitis.Results: The bacterial isolation rate was 39.2%. There were 191 strains of Gram-positive cocci, accounting for the majority of all isolates (67.0%, among which methicillin-sensitive coagulase-negative staphylococci was the most frequent (127 strains, 44.5%, followed by methicillin-resistant coagulase-negative staphylococci (37 strains, 12.7%. All 76 Gram-positive bacillary isolates (26.7% were from the genus Corynebacterium. Among the 16 Gram-negative bacillary isolates (5.9%, the most frequent was Escherichia coli (1.0%. The bacterial isolation rate was higher in patients >60 years old, and was lower in patients with dry eye syndrome, patients under topical treatment for other ocular disorders, and patients with hyperlipidemia. There was no significant difference in bacterial isolation rate with respect to the presence/absence of diabetes mellitus, steroid therapy, dialysis, or

  4. A study of static, kinetic, and dynamic visual acuity in 102 Japanese professional baseball players

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    Hoshina K

    2013-03-01

    Full Text Available Kohji Hoshina,1 Yuichi Tagami,2 Osamu Mimura,3 Hiroshi Edagawa,4 Masao Matsubara,5 Teiichi Nakayama6 1Hoshina Eye Clinic, Nishinomiya, Japan; 2Department of Ophthalmology, Kobe Century Memorial Hospital, Kobe, Japan; 3Department of Ophthalmology, Hyogo College of Medicine, Nishinomiya, Japan; 4Edagawa Eye Clinic, Tokyo, Japan; 5Department of Ophthalmology, Tokyo Women's Medical University Medical Center East, Tokyo, Japan; 6Ritsumeikan University, Kyoto, Japan Background: It seemed that visual functions might have some effects on the performance of baseball players. We measured static, kinetic, and dynamic visual acuity (SVA, KVA, and DVA, respectively of Japanese professional baseball players to ascertain whether there would be any difference in SVA, KVA, and DVA among player groups stratified according to their performance level. Methods: The subjects were 102 male professional baseball players with a mean age of 26 years who were members of a Japanese professional baseball club from 2000 to 2009. They were stratified into three groups according to their performance level: A (players who were on the roster of the top-level team all the time throughout the study period, B (players who were on the roster of the top-level team sometimes but not all the time, and C (players who were never on the roster of the top-level team. They were interviewed for the use of corrective visual aids, and examined for SVA, KVA, and DVA. The measurements of these parameters were compared among groups A, B, and C. We also investigated and analyzed the association of KVA or DVA with player position (pitchers or fielders and with hand dominance for batting. KVA was compared between the pitchers and the fielders because they each require different playing skills. DVA was compared between the right-handed and the left-handed batters. Results: There was no statistically significant difference among groups A, B, and C. There was a statistically significant difference in

  5. Unilateral macular edema with central retinal vein occlusion in systemic lupus erythematosus: a case report

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    Noma H

    2013-05-01

    Full Text Available Hidetaka Noma,1 Hiroshi Shimizu,1 Tatsuya Mimura21Department of Ophthalmology, Yachiyo Medical Center, Tokyo Women's Medical University, 2Department of Ophthalmology, Medical Center East, Tokyo Women's Medical University, Tokyo, JapanAbstract: Central retinal vein occlusion (CRVO is frequent in patients with systemic lupus erythematosus (SLE, but the treatment of the macular edema with this disease is extremely difficult. We report a case of cystoid macular edema (CME secondary to unilateral CRVO in a patient with SLE that responded to intravitreous injection of an anti-vascular endothelial growth factor (VEGF agent. A 33-year-old Japanese woman was referred to our department with unilateral impairment of vision. Microperimetry (MP-1 showed a cessation of foveal sensitivity. Fluorescein angiography showed CME without ischaemia of the macular region or peripheral retina (nonischemic CRVO. A diagnosis of CME and unilateral nonischemic CRVO combined with SLE was made and intravitreous anti-VEGF therapy was given. A sample of aqueous humor was harvested at the start of intravitreous injection after obtaining informed consent. Then the levels of VEGF and monocyte chemotactic protein (MCP-1 were measured in the aqueous humor by enzyme-linked immunosorbent assay, revealing that VEGF was 234 pg/mL and MCP-1 was 501 pg/mL. Two weeks later, left eye vision improved to 20/20. Optical coherence tomography (OCT showed considerable amelioration of retinal swelling and CME. MP-1 showed a marked increase of foveal sensitivity. However, she had recurrence of edema 3 months later. After harvesting aqueous humor again, intravitreous injection of an anti-VEGF agent was repeated for CME. The aqueous VEGF and MCP-1 levels were 156 pg/mL and 360 pg/mL, respectively. These findings suggest that inflammation was improved by intravitreous injection of bevacizumab. Intravitreous injection of anti-VEGF agents may be effective for CME due to nonischemic CRVO in SLE patients

  6. Human epidermal growth factor receptor-2 overexpression and amplification in metastatic and recurrent high grade or type 2 endometrial carcinomas

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    Kato R

    2013-08-01

    Full Text Available Rina Kato,1 Kiyoshi Hasegawa,1 Risa Ishii,1 Akiko Owaki,1 Yutaka Torii,1 Shuko Oe,1 Hiroshi Hirasawa,2 Yoichi Kobayashi,3 Yasuhiro Udagawa1 1Department of Obstetrics and Gynecology, Fujita Health University School of Medicine, Toyoake, Japan; 2Department of Pathology, Fujita Health University School of Medicine, Toyoake, Japan; 3Department of Obstetrics and Gynecology, Kyorin University School of Medicine, Mitaka, Japan Introduction: Human epidermal growth factor receptor (HER-2 overexpression or gene amplification is more common in high-grade or type 2 endometrial carcinomas. We assessed the discordance of HER-2 expression between primary and metastatic or recurrent endometrial carcinomas. Materials and methods: Thirty-six primary, along with 14 metastatic and five recurrent tumors (matched to primaries, pathologically confirmed as high-grade or type 2 endometrial carcinomas, were submitted for immunohistochemistry (IHC for HER-2. Fluorescence in situ hybridization was performed when the tumors showed HER-2 overexpression (≥2+ IHC score. The results of the IHC and fluorescence in situ hybridization assays were compared between the primary and metastatic or recurrent tumors. The relationships between HER-2 expression and clinicopathological factors or prognosis were investigated. Results: HER-2 overexpression and HER-2 amplification (a ratio of HER-2 copies to chromosome 17 [CEP17] copies ≥2.2 were detected in 33.3% (twelve of 36 patients and 5.6% (two of 36 patients of primary tumors, respectively. HER-2 overexpression was not associated with clinicopathological factors or prognosis. In 19 tumor specimens obtained from metastatic or recurrent tumors, HER-2 overexpression and HER-2 amplification were detected in 57.9% (eleven patients and 15.8% (three patients, respectively. HER-2 overexpression tended to predict a worse prognosis. Conclusion: HER-2 expression in metastatic or recurrent tumors was more frequent than in matched primary high

  7. Behavior management approach for agitated behavior in Japanese patients with dementia: a pilot study

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    Sato J

    2012-12-01

    Full Text Available Junko Sato,1 Shutaro Nakaaki,2 Katsuyoshi Torii,1 Mizuki Oka,2 Atsushi Negi,1 Hiroshi Tatsumi,3 Jin Narumoto,4 Toshi A Furukawa,5 Masaru Mimura21Department of Psychiatry and Cognitive-Behavioral Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, 2Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, 3Department of Health Science, Faculty of Psychological and Physical Science, Aichi Gakuin University, Nagoya, 4Department of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, 5Department of Health Promotion and Human Behavior (Cognitive-Behavioral Medicine, Kyoto University Graduate School of Medicine/School of Public Health, Kyoto, JapanBackground: Agitated behaviors are frequently observed in patients with dementia and can cause severe distress to caregivers. However, little evidence of the efficacy of nonpharmacological interventions for agitated behaviors exists for patients with dementia. The present pilot study aimed to evaluate a behavioral management program developed by the Seattle Protocols for patients with agitated behaviors in Japan.Methods: Eighteen patients with dementia (Alzheimer’s disease, n = 14; dementia with Lewy bodies, n = 4 participated in an open study testing the effectiveness of a behavioral management program. The intervention consisted of 20 sessions over the course of 3 months. The primary outcomes were severity of agitation in dementia, as measured using the Agitated Behavior in Dementia scale (ABID and the Cohen-Mansfield Agitation Inventory (CMAI.Results: The behavioral management program resulted in significant reductions in total scores on both the ABID and CMAI. Although both physically agitated and verbally agitated behavior scores on the ABID improved significantly, symptoms of psychosis did not improve after the intervention.Conclusion: The behavioral management technique may be beneficial to distressed caregivers of

  8. Pulmonary rehabilitation for COPD improves exercise time rather than exercise tolerance: effects and mechanisms

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    Miki K

    2017-04-01

    Full Text Available Keisuke Miki,1 Ryoji Maekura,1 Seigo Kitada,1 Mari Miki,1 Kenji Yoshimura,1 Hiroshi Yamamoto,2 Toshiko Kawabe,2 Hiroyuki Kagawa,1 Yohei Oshitani,1 Akitoshi Satomi,1 Kohei Nishida,1 Nobuhiko Sawa,1 Kimiko Inoue2 1Department of Respiratory Medicine, 2Department of Rehabilitation Medicine, National Hospital Organization, Toneyama National Hospital, Toyonaka, Japan Background: COPD patients undergoing pulmonary rehabilitation (PR show various responses. The purpose of this study was to investigate the possible mechanisms and predictors of the response to PR in COPD patients.Methods: Thirty-six stable COPD patients underwent PR including a 4-week high-intensity exercise training program, and they were evaluated by cardiopulmonary exercise testing. All patients (mean age 69 years, severe and very severe COPD 94% were classified into four groups by whether the exercise time (Tex or the peak oxygen uptake (VO2 increased after PR: two factors increased (both the Tex and the peak VO2 increased; two factors decreased; time only increased (the Tex increased, but the peak VO2 economized; and VO2 only increased (the Tex decreased, but the peak VO2 increased. Within all patients, the relationships between baseline variables and the post-to-pre-change ratio of the time–slope, Tex/(peak minus resting VO2, were investigated.Results: Compared with the two factors increased group (n=11, in the time only increased group (n=18, the mean differences from pre-PR at peak exercise in 1 minute ventilation (VE (P=0.004, VO2 (P<0.0001, and carbon dioxide output (VCO2 (P<0.0001 were lower, 2 VE/VO2 (P=0.034 and VE/VCO2 (P=0.006 were higher, and 3 the dead space/tidal volume ratio (VD/VT and the dyspnea level were similar. After PR, there was no significant difference in the ratio of the observed peak heart rate (HR to the predicted peak HR (220 – age [years] between the two groups. A significant negative correlation with the baseline time–slope (r=-0.496, P=0.002 and a

  9. Conservative treatment for late-onset bleb leaks after trabeculectomy with mitomycin C in patients with ocular surface disease

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    Sagara H

    2012-08-01

    Full Text Available Hideto Sagara,1,2 Tomohiro Iida,2,3 Kimimori Saito,4 Hiroki Noji,2 Masashi Ogasawara,2 Hiroshi Oyamada21The Marui Eye Clinic, Fukushima, 2Department of Ophthalmology, Fukushima Medical University School of Medicine, Fukushima, 3Tokyo Women's Medical University, Tokyo, 4Matuki Eye Clinic, Fukushima, JapanBackground: Sodium hyaluronate and autologous serum eye drops are used to treat ocular surface disease (OSD and are reported to prevent and treat late-onset bleb leaks following trabeculectomy with mitomycin C. In this study, we evaluated the efficacy of a combination of sodium hyaluronate and autologous serum eye drops and treatment for obstructive meibomian gland dysfunction as a therapy for late-onset bleb leaks after trabeculectomy with mitomycin C.Methods: This was a retrospective, interventional, nonsimultaneous study of 12 subjects (12 eyes of mean age of 64.3 ± 18.3 years with OSD and apparent late-onset bleb leaks following trabeculectomy with mitomycin C between 1998 and 2008. We compared patients diagnosed with leakages before July 2005, who had been treated with separate eye drop solutions containing 0.1% sodium hyaluronate, 50% autologous serum, and 0.3% ofloxacin (sodium hyaluronate and autologous serum group, n = 7, with patients diagnosed from August 2005 to December 2008, who were treated with a combination of eye drops (0.1% sodium hyaluronate, 50% autologous serum, and 0.08% levofloxacin hydrate and eyelid massage and warm compresses for obstructive meibomian gland dysfunction (combination eye drop group, n = 5.Results: Leakage was resolved in one patient (14.3% in the separately treated sodium hyaluronate and autologous serum eye drop group and in five patients (100% in the combination eye drop group (P = 0.015. The period after resolution of leakage with conservative treatment was 23 months in the one eye in the sodium hyaluronate and autologous serum group and 36–61 (mean 52.4 ± 10.1 months in the five eyes in the

  10. Tipepidine in children with attention deficit/hyperactivity disorder: a 4-week, open-label, preliminary study

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    Sasaki T

    2014-01-01

    Full Text Available Tsuyoshi Sasaki,1,2 Kenji Hashimoto,3 Masumi Tachibana,1 Tsutomu Kurata,1 Keiko Okawada,1 Maki Ishikawa,1 Hiroshi Kimura,2 Hideki Komatsu,2 Masatomo Ishikawa,2 Tadashi Hasegawa,2 Akihiro Shiina,1 Tasuku Hashimoto,2 Nobuhisa Kanahara,3 Tetsuya Shiraishi,2 Masaomi Iyo1–31Department of Child Psychiatry, Chiba University Hospital, 2Department of Psychiatry, Chiba University Graduate School of Medicine, 3Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, JapanBackground: Tipepidine (3-[di-2-thienylmethylene]-1-methylpiperidine has been used solely as a nonnarcotic antitussive in Japan since 1959. The safety of tipepidine in children and adults has already been established. It is reported that tipepidine inhibits G-protein-coupled inwardly rectifying potassium (GIRK-channel currents. The inhibition of GIRK channels by tipepidine is expected to modulate the level of monoamines in the brain. We put forward the hypothesis that tipepidine can improve attention deficit/hyperactivity disorder (ADHD symptoms by modulating monoaminergic neurotransmission through the inhibition of GIRK channels. The purpose of this open-label trial was to confirm whether treatment with tipepidine can improve symptoms in pediatric patients with ADHD.Subjects and methods: This was a 4-week, open-label, proof-of-efficacy pilot study for pediatric subjects with ADHD. Ten pediatric ADHD subjects (70% male; mean age, 9.9 years; combined [inattentive and hyperactive/impulsive] subtype, n=7; inattentive subtype, n=3; hyperimpulsive subtype, n=0 received tipepidine hibenzate taken orally at 30 mg/day for 4 weeks. All subjects were assessed using the ADHD Rating Scale IV (ADHD-RS, Japanese version, and the Das–Naglieri Cognitive Assessment System (DN-CAS, Japanese version.Results: A comparison of baseline scores and 4-week end-point scores showed that all the ADHD-RS scores (total scores, hyperimpulsive subscores, and inattentive subscores

  11. Attitudes toward metabolic adverse events among patients with schizophrenia in Japan

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    Sugawara N

    2016-02-01

    Full Text Available Norio Sugawara,1–3 Norio Yasui-Furukori,2,3 Manabu Yamazaki,4 Kazutaka Shimoda,3,5 Takao Mori,4 Takuro Sugai,3,6 Hiroshi Matsuda,4 Yutaro Suzuki,3,6 Yoshitake Minami,4 Yuji Ozeki,3,5 Kurefu Okamoto,4 Toyoaki Sagae,7 Toshiyuki Someya3,6 1Aomori Prefectural Center for Mental Health and Welfare, Aomori, 2Department of Neuropsychiatry, Hirosaki University School of Medicine, Hirosaki, 3Japanese Society of Clinical Neuropsychopharmacology, 4Japan Psychiatric Hospital Association, Tokyo, 5Department of Psychiatry, Dokkyo Medical University School of Medicine, Mibu, 6Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, 7Department of Health and Nutrition, Yamagata Prefectural Yonezawa University of Nutrition Sciences, Yonezawa, Japan Background: Metabolic syndrome is a growing concern among patients with schizophrenia because metabolic abnormalities are widely regarded as a major risk factor for cardiovascular disease and premature death. The current study assessed attitudes toward metabolic adverse events among patients with schizophrenia. Methods: A brief questionnaire was constructed to investigate patient recognition of the following broad areas: dietary habits, lifestyle, self-monitoring, knowledge, and medical practice. Between January 2012 and June 2013, questionnaires were sent to patients associated with 520 outpatient facilities and 247 inpatient facilities belonging to the Japan Psychiatric Hospital Association. All of the participants (n=22,072; inpatients =15,170, outpatients =6,902 were diagnosed with schizophrenia based on the Diagnostic and Statistical Manual of Mental Disorders, fourth edition, or the International Classification of Diseases, tenth revision. Results: Approximately 55.0% (8,069/14,669 of inpatients and 44.8% of outpatients (2,978/6,649 reported that they did not exercise at all. Although 60.9% (4,116/6,760 of outpatients reported that they felt obese, only 35.6% (5

  12. Social and geographical inequalities in suicide in Japan from 1975 through 2005: a census-based longitudinal analysis.

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    Etsuji Suzuki

    Full Text Available BACKGROUND: Despite advances in our understanding of the countercyclical association between economic contraction and suicide, less is known about the levels of and changes in inequalities in suicide. The authors examined social and geographical inequalities in suicide in Japan from 1975 through 2005. METHODS: Based on quinquennial vital statistics and census data, the authors analyzed the entire population aged 25-64 years. The total number of suicides was 75,840 men and 30,487 women. For each sex, the authors estimated odds ratios (ORs and 95% credible intervals (CIs for suicide using multilevel logistic regression models with "cells" (cross-tabulated by age and occupation at level 1, seven different years at level 2, and 47 prefectures at level 3. Prefecture-level variance was used as an estimate of geographical inequalities in suicide. RESULTS: Adjusting for age and time-trends, the lowest odds for suicide was observed among production process and related workers (the reference group in both sexes. The highest OR for men was 2.52 (95% CI: 2.43, 2.61 among service workers, whereas the highest OR for women was 9.24 (95% CI: 7.03, 12.13 among security workers. The degree of occupational inequalities increased among men with a striking change in the pattern. Among women, we observed a steady decline in suicide risk across all occupations, except for administrative and managerial workers and transport and communication workers. After adjusting for individual age, occupation, and time-trends, prefecture-specific ORs ranged from 0.76 (Nara Prefecture to 1.36 (Akita Prefecture for men and from 0.79 (Kanagawa Prefecture to 1.22 (Akita Prefecture for women. Geographical inequalities have increased primarily among men since 1995. CONCLUSIONS: The present findings demonstrate a striking temporal change in the pattern of social inequalities in suicide among men. Further, geographical inequalities in suicide have considerably increased across 47

  13. Efficacy of a trunk orthosis with joints providing resistive force on low-back load in elderly persons during static standing

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    Katsuhira J

    2015-09-01

    Full Text Available Junji Katsuhira,1 Ko Matsudaira,2 Tadashi Yasui,3 Shinno Iijima,4 Akihiro Ito4 1Department of Nursing and Rehabilitation Science at Odawara, International University of Health and Welfare, Odawara, Kanagawa, 2Department of Medical Research and Management for Musculoskeletal Pain, 22nd Century Medical and Research Center, The University of Tokyo, Tokyo, 3Kawamura-Gishi Company, Ltd., Daito-shi, Osaka, 4Graduate School of International University of Health and Welfare, Otawara, Tochigi, Japan Purpose: Postural alignment of elderly people becomes poor due to aging, possibly leading to low-back pain and spinal deformity. Although there are several interventions for treating these conditions, no previous study has reported the effectiveness of a spinal orthosis or lumbosacral orthosis (LSO in healthy elderly people without specific spinal deformity. We therefore developed a trunk orthosis to decrease low-back muscle activity while training good postural alignment through resistive force provided by joints with springs (here, called the ORF, which stands for orthosis with joints providing resistive force as a preventive method against abnormal posture and low-back pain in healthy elderly persons. Patients and methods: Fifteen community-dwelling elderly men participated in this study. Participants stood freely for 10 seconds in a laboratory setting under three conditions: without an orthosis, with the ORF, and with an LSO. The Damen corset LSO was selected as it is frequently prescribed for patients with low-back pain. Postural alignment during static standing was recorded using a three-dimensional motion capture system employing infrared cameras. Two force plates were used to record center of pressure. Electromyograms were obtained for bilateral erector spinae (ES, left internal abdominal oblique, and right gluteus medius muscles. Results: Pelvis forward tilt angle tended to increase while wearing the ORF and decrease while wearing the LSO, but these

  14. Impact of inpatient caseload, emergency department duties, and online learning resource on General Medicine In-Training Examination scores in Japan

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    Kinoshita K

    2015-10-01

    Full Text Available Kensuke Kinoshita,1 Yusuke Tsugawa,2 Taro Shimizu,3 Yusuke Tanoue,4 Ryota Konishi,5 Yuji Nishizaki,6 Toshiaki Shiojiri,7 Yasuharu Tokuda8 1Department of Medicine, Mito Kyodo General Hospital, University of Tsukuba, Mito City, Ibaraki, Japan; 2Department of Health Policy and Management, Harvard T.H. Chan School of Public Health, Boston, MA, USA; 3Tokyo Joto Hospital, Koto-ku, Tokyo, 4Good Medicine Japan, Miyagi, 5Department of General Internal Medicine, Kanto Rosai Hospital, Kawasaki, Kanagawa, 6Department of Cardiology, Juntendo University Graduate School of Medicine, Tokyo, 7Department of General Internal Medicine, Asahi General Hospital, Asahi, Chiba, 8Japan Community Healthcare Organization, Minato-ku, Tokyo, Japan Background: Both clinical workload and access to learning resource are important components of educational environment and may have effects on clinical knowledge of residents. Methods: We conducted a survey with a clinical knowledge evaluation involving postgraduate year (PGY-1 and -2 resident physicians at teaching hospitals offering 2-year postgraduate training programs required for residents in Japan, using the General Medicine In-Training Examination (GM-ITE. An individual-level analysis was conducted to examine the impact of the number of assigned patients and emergency department (ED duty on the residents' GM-ITE scores by fitting a multivariable generalized estimating equations. In hospital-level analysis, we evaluated the relationship between for the number of UpToDate reviews for each hospital and for the hospitals' mean GM-ITE score. Results: A total of 431 PGY-1 and 618 PGY-2 residents participated. Residents with four or five times per month of the ED duties exhibited the highest mean scores compared to those with greater or fewer ED duties. Those with largest number of inpatients in charge exhibited the highest mean scores compared to the residents with fewer inpatients in charge. Hospitals with the greater Up

  15. Elevation of urinary liver-type fatty acid binding protein after cardiac catheterization related to cardiovascular events

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    Kamijo-Ikemori A

    2015-08-01

    Full Text Available Atsuko Kamijo-Ikemori,1,3 Nobuyuki Hashimoto,2 Takeshi Sugaya,1 Katsuomi Matsui,1 Mikako Hisamichi,1 Yugo Shibagaki,1 Fumihiko Miyake,2 Kenjiro Kimura1 1Department of Nephrology and Hypertension, 2Department of Cardiology, 3Department of Anatomy, St Marianna University School of Medicine, Kawasaki, Kanagawa, Japan Purpose: Contrast medium (CM induces tubular hypoxia via endothelial damage due to direct cytotoxicity or viscosity. Urinary liver-type fatty acid binding protein (L-FABP increases along with tubular hypoxia and may be a detector of systemic circulation injury. The aim of this study was to evaluate the clinical usefulness of detecting increases in urinary L-FABP levels due to administration of CM, as a prognostic biomarker for cardiovascular disease in patients without occurrence of CM-induced nephropathy undergoing cardiac catheterization procedure (CCP. Methods: Retrospective longitudinal analyses of the relationship between urinary L-FABP levels and occurrence of cardiovascular events were performed (n=29. Urinary L-FABP was measured by ELISA before CCP, and at 6, 12, 24, and 48 hours after CCP. Results: Urinary L-FABP levels were significantly higher at 12 hours (P<0.05 and 24 hours (P<0.005 after CCP compared with before CCP, only in the patients with occurrence of cardiovascular events (n=17, but not in those without cardiovascular events (n=12. The parameter with the largest area under the curve (0.816 for predicting the occurrence of cardiovascular events was the change in urinary L-FABP at 24 hours after CCP. The difference in urinary L-FABP levels (ΔL-FABP ≥11.0 µg/g creatinine between before CCP and at 24 hours after CCP was a risk factor for the occurrence of cardiovascular events (hazard ratio, 4.93; 95% confidence interval, 1.27–19.13; P=0.021. Conclusion: Measurement of urinary L-FABP before CCP and at 24 hours after CCP in patients with mild to moderate renal dysfunction may be an important indicator for risk

  16. Symptom predictors of response to electroconvulsive therapy in older patients with treatment-resistant depression

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    Tominaga K

    2011-07-01

    Full Text Available Keiichiro Tominaga¹, Mioto Okazaki¹, Hisashi Higuchi¹, Itaru Utagawa¹, Etsuko Nakamura², Noboru Yamaguchi¹¹Department of Neuropsychiatry, St Marianna University School of Medicine, Miyamae-ku, Kawasaki City, Kanagawa, ²Tsurukawa Sanatorium Hospital, Machida City, Tokyo, JapanBackground: Electroconvulsive therapy (ECT has been used for treatment-resistant depression. However, predictors of response to ECT have not been adequately studied using the Montgomery and Åsberg Depression Rating Scale, especially in older patients with treatment-resistant depression.Methods: This study included 18 Japanese patients who fulfilled the Diagnostic and Statistical Manual of Mental Disorders Fourth Edition Text Revision criteria for a diagnosis of major depressive disorder or bipolar disorder with a current major depressive episode, and met the definition of treatment-resistant depression outlined by Thase and Rush, scoring ≥21 on the Montgomery and Åsberg Depression Rating Scale. The three-factor model of the Montgomery and Åsberg Depression Rating Scale was used for analysis. Factor 1 was defined by three items, factor 2 by four items, and factor 3 by three items, representing dysphoria, retardation, and vegetative symptoms, respectively. ECT was performed twice a week for a total of six sessions using a Thymatron System IV device with the brief pulse technique. Clinical responses were defined on the basis of a ≥50% decrease in total pretreatment Montgomery and Åsberg Depression Rating Scale scores.Results: The mean pretreatment factor 2 score for responders (n = 7 was significantly lower than that for nonresponders (n = 11. Furthermore, a significant difference in mean factor 3 score between responders and nonresponders was observed one week after six sessions of ECT, indicating a time lag of response. No significant differences were observed for age, number of previous episodes, and duration of the current episode between responders and

  17. Effects of plant sterols derived from Aloe vera gel on human dermal fibroblasts in vitro and on skin condition in Japanese women

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    Tanaka M

    2015-02-01

    Full Text Available Miyuki Tanaka,1 Eriko Misawa,1 Koji Yamauchi,1 Fumiaki Abe,1 Chiaki Ishizaki2 1Functional Food Research Department, Food Science and Technology Institute, Morinaga Milk Industry Co, Ltd, Zama, Kanagawa, 2Ebisu Skin Research Center, Inforward, Inc., Tokyo, Japan Background: Aloe is known for its topical use for treating wounds and burns. Many previous studies reported the healing effects of Aloe vera. However, there are few clinical studies on the effect of orally administered A. vera gel on the skin. Aloe sterols are a type of plant sterols that have the capability to regulate the metabolism of glucose and lipids. In a recent study, we confirmed that ingested Aloe sterols reached the peripheral tissues through the bloodstream. However, their influence on dermal fibroblasts has not been investigated. Methods: First, we investigated the capability of Aloe sterols (cycloartenol and lophenol to stimulate human dermal fibroblasts in vitro. Then, we investigated the effect of intake of Aloe vera gel powder (AVGP containing 40 µg Aloe sterols on the skin conditions in Japanese women with dry skin in a randomized, double-blind, placebo-controlled trial. Results: After cocultivation with Aloe sterols, the production of collagen and hyaluronic acid increased by approximately two-fold and 1.5-fold, and gene expression levels of these enzymes responsible for their synthesis were also observed in human dermal fibroblasts. An increase in arm skin hydration was observed at 8 weeks in the AVGP group, whereas a slight decrease in arm skin hydration was noted in the placebo group. However, there was no statistical difference between AVGP and placebo groups in skin moisture. In subgroup analysis, the change in the mean wrinkle depth was significantly lower in the AVGP group than in the control group. In addition, percent body fat after 8 weeks was significantly lower in the AVGP group. No AVGP intake-dependent harmful phenomenon was observed during the intake

  18. Ease-of-use preference for the ELLIPTA® dry powder inhaler over a commonly used single-dose capsule dry powder inhaler by inhalation device-naïve Japanese volunteers aged 40 years or older

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    Komase Y

    2014-12-01

    Full Text Available Yuko Komase,1 Akimoto Asako,2 Akihiro Kobayashi,3 Raj Sharma4 1Department of Respiratory Internal Medicine, St Marianna University School of Medicine, Yokohama City Seibu Hospital, Yokohama, Kanagawa, Japan; 2MA Respiratory Department, Development and Medical Affairs Unit, GlaxoSmithKline KK, Tokyo, Japan; 3Biomedical Data Sciences Department, GlaxoSmithKline KK, Tokyo, Japan; 4Global Respiratory Franchise Medical Department, GSK, Stockley Park, UK Background: In patients receiving inhaled medication, dissatisfaction with and difficulty in using the inhaler can affect treatment adherence. The incidence of handling errors is typically higher in the elderly than in younger people. The aim of the study was to assess inhaler preference for and handling errors with the ELLIPTA® dry powder inhaler (DPI, (GSK, compared with the established BREEZHALER™, a single-dose capsule DPI (Novartis, in inhalation device-naïve Japanese volunteers aged ≥40 years. Methods: In this open-label, nondrug interventional, crossover DPI preference study comparing the ELLIPTA DPI and BREEZHALER, 150 subjects were randomized to handle the ELLIPTA or BREEZHALER DPIs until the point of inhalation, without receiving verbal or demonstrative instruction (first attempt. Subjects then crossed over to the other inhaler. Preference was assessed using a self-completed questionnaire. Inhaler handling was assessed by a trained assessor using a checklist. Subjects did not inhale any medication in the study, so efficacy and safety were not measured. Results: The ELLIPTA DPI was preferred to the BREEZHALER by 89% of subjects (odds ratio [OR] 70.14, 95% confidence interval [CI] 33.69–146.01; P-value not applicable for this inhaler for ease of use, by 63% of subjects (OR 2.98, CI 1.87–4.77; P<0.0001 for ease of determining the number of doses remaining in the inhaler, by 91% for number of steps required, and by 93% for time needed for handling the inhaler. The BREEZHALER was

  19. EXAMINATION ABOUT INFLUENCE FOR PRECISION OF 3D IMAGE MEASUREMENT FROM THE GROUND CONTROL POINT MEASUREMENT AND SURFACE MATCHING

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    T. Anai

    2015-05-01

    Full Text Available As the 3D image measurement software is now widely used with the recent development of computer-vision technology, the 3D measurement from the image is now has acquired the application field from desktop objects as wide as the topography survey in large geographical areas. Especially, the orientation, which used to be a complicated process in the heretofore image measurement, can be now performed automatically by simply taking many pictures around the object. And in the case of fully textured object, the 3D measurement of surface features is now done all automatically from the orientated images, and greatly facilitated the acquisition of the dense 3D point cloud from images with high precision. With all this development in the background, in the case of small and the middle size objects, we are now furnishing the all-around 3D measurement by a single digital camera sold on the market. And we have also developed the technology of the topographical measurement with the air-borne images taken by a small UAV [1~5]. In this present study, in the case of the small size objects, we examine the accuracy of surface measurement (Matching by the data of the experiments. And as to the topographic measurement, we examine the influence of GCP distribution on the accuracy by the data of the experiments. Besides, we examined the difference of the analytical results in each of the 3D image measurement software. This document reviews the processing flow of orientation and the 3D measurement of each software and explains the feature of the each software. And as to the verification of the precision of stereo-matching, we measured the test plane and the test sphere of the known form and assessed the result. As to the topography measurement, we used the air-borne image data photographed at the test field in Yadorigi of Matsuda City, Kanagawa Prefecture JAPAN. We have constructed Ground Control Point which measured by RTK-GPS and Total Station. And we show the results

  20. Drug diffusion and biological responses of arteries using a drug-eluting stent with nonuniform coating

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    Saito N

    2016-03-01

    Full Text Available Noboru Saito, Yuhei Mori, Sayaka Uchiyama Terumo Corporation R&D Center, Inokuchi, Nakai-machi, Ashigarakami-gun, Kanagawa, Japan Abstract: The purpose of this study was to determine the effect of a nonuniform coating, abluminal-gradient coating (AGC, which leaves the abluminal surface of the curves and links parts of the stent free from the drug coating, on the diffusion direction of the drug and the biological responses of the artery to drug-eluting stent (DES by comparing the AGC-sirolimus stent and the conventional full-surface coating (CFC sirolimus stent. The study aimed to verify whether the AGC approach was appropriate for the development of a safer DES, minimizing the risks of stent thrombosis due to delayed endothelialization by the drug and distal embolization due to cracking of the coating layer on the hinge parts of the DES on stent expansion. In the in vitro local drug diffusion study, we used rhodamine B as a model drug, and rhodamine B released from the AGC stent diffused predominantly into the abluminal side of the alginate artery model. Conversely, rhodamine B released from the CFC stent quickly spread to the luminal side of the artery model, where endothelial cell regeneration is required. In the biological responses study, the luminal surface of the iliac artery implanted with the AGC-sirolimus stent in a rabbit iliac artery for 2 weeks was completely covered with endothelial-like cells. On the other hand, the luminal surface of the iliac artery implanted with the CFC-sirolimus stent for 2 weeks only showed partial coverage with endothelial-like cells. While thrombosis was observed in two of the three CFC-sirolimus stents, it was observed in only one of the three AGC-sirolimus stents. Taken together, these findings indicate that the designed nonuniform coating (AGC is an appropriate approach to ensure a safer DES. However, the number of studies is limited and a larger study should be conducted to reach a statistically

  1. Determination of the appropriate catheter length for needle thoracostomy by using computed tomography scans of trauma patients in Japan.

    Science.gov (United States)

    Yamagiwa, Takeshi; Morita, Seiji; Yamamoto, Rie; Seki, Tomoko; Sugimoto, Katsuhiko; Inokuchi, Sadaki

    2012-01-01

    Previous studies reported a high failure rate in relieving tension pneumothorax by needle thoracostomy, because the catheter was not sufficiently long to access the pleural space. The Advanced Trauma Life Support guideline recommends needle thoracostomy at the second intercostal space in the middle clavicular line using a 5.0-cm catheter, whereas the corresponding guideline in Japan does not mention a catheter length. It is necessary to measure the chest wall thickness (CWT) and determine the appropriate catheter length taking the differences of habitus in race and region into consideration. This study was designed to analyse CWT in Japanese trauma patients by computed tomography and to determine the percentage of patients whose pleural space would be accessible using a 5.0-cm catheter. We performed a retrospective review of chest computed tomography of 256 adult Japanese trauma patients who were admitted to the level 1 trauma centre of Tokai University Hospital in Kanagawa, Japan between January and July 2008. In 256 patients, the CWT at 512 sites (left and right sides) was measured by chest computed tomography at the second intercostal space in the middle clavicular line. The frequency of measurement sites <5.0 cm was calculated simultaneously. The samples were divided according to gender, side (left and right), abbreviated injury scale (<3, ≧3), arm position during examination (up/down), and the existence or non-existence of associated injuries (pneumothorax, subcutaneous emphysema, and fracture of the sternum and ribs); the CWT of each group was compared. The mean CWT measured in 192 males and 64 females was 3.06±1.02 cm. The CWT values at 483 sites (94.3%) were less than 5.0 cm. The CWT of females was significantly greater than that of males (3.66 cm vs. 2.85 cm, p<0.0001), and patients with subcutaneous emphysema had greater CWTs than those without it (4.16 cm vs. 3.01 cm, p<0.0001). The mean CWT at the second intercostal space in the middle clavicular

  2. Examination about Influence for Precision of 3d Image Measurement from the Ground Control Point Measurement and Surface Matching

    Science.gov (United States)

    Anai, T.; Kochi, N.; Yamada, M.; Sasaki, T.; Otani, H.; Sasaki, D.; Nishimura, S.; Kimoto, K.; Yasui, N.

    2015-05-01

    As the 3D image measurement software is now widely used with the recent development of computer-vision technology, the 3D measurement from the image is now has acquired the application field from desktop objects as wide as the topography survey in large geographical areas. Especially, the orientation, which used to be a complicated process in the heretofore image measurement, can be now performed automatically by simply taking many pictures around the object. And in the case of fully textured object, the 3D measurement of surface features is now done all automatically from the orientated images, and greatly facilitated the acquisition of the dense 3D point cloud from images with high precision. With all this development in the background, in the case of small and the middle size objects, we are now furnishing the all-around 3D measurement by a single digital camera sold on the market. And we have also developed the technology of the topographical measurement with the air-borne images taken by a small UAV [1~5]. In this present study, in the case of the small size objects, we examine the accuracy of surface measurement (Matching) by the data of the experiments. And as to the topographic measurement, we examine the influence of GCP distribution on the accuracy by the data of the experiments. Besides, we examined the difference of the analytical results in each of the 3D image measurement software. This document reviews the processing flow of orientation and the 3D measurement of each software and explains the feature of the each software. And as to the verification of the precision of stereo-matching, we measured the test plane and the test sphere of the known form and assessed the result. As to the topography measurement, we used the air-borne image data photographed at the test field in Yadorigi of Matsuda City, Kanagawa Prefecture JAPAN. We have constructed Ground Control Point which measured by RTK-GPS and Total Station. And we show the results of analysis made

  3. Bridging Scales: Developing a Framework to Build a City-Scale Environmental Scenario for Japanese Municipalities

    Science.gov (United States)

    Hashimoto, S.; Fujita, T.; Nakayama, T.; Xu, K.

    2007-12-01

    , and 3) started implementing it to the city of Kawasaki, Kanagawa, Japan, in cooperation with municipal officials and stakeholders. The participatory process is to develop city-scale environmental scenarios toward low carbon society, referring international and domestic environmental scenarios. Though the scenario development is still in process, it has already brought practical knowledge about and experience on how to bridge scenarios developed for different temporal and spatial scales.

  4. Additive effects of cilnidipine, an L-/N-type calcium channel blocker, and an angiotensin II receptor blocker on reducing cardiorenal damage in Otsuka Long-Evans Tokushima Fatty rats with type 2 diabetes mellitus

    Directory of Open Access Journals (Sweden)

    Mori Y

    2014-06-01

    Full Text Available Yutaka Mori,1,2 Shizuka Aritomi,3 Kazumi Niinuma,3 Tarou Nakamura,3 Kenichi Matsuura,1 Junichi Yokoyama,1 Kazunori Utsunomiya1 1Division of Diabetes and Endocrinology, Department of Internal Medicine, The Jikei University School of Medicine, Minato-ku, Japan; 2Department of Clinical Research, National Hospital Organization, Utsunomiya National Hospital, Utsunomiya, Japan; 3Research Center, Ajinomoto Pharmaceuticals Co, Ltd, Kanagawa, Japan Abstract: Cilnidipine (Cil, which is an L-/N-type calcium channel blocker (CCB, has been known to provide renal protection by decreasing the activity of the sympathetic nervous system (SNS and the renin–angiotensin system. In this study, we compared the effects of the combination of Cil and amlodipine (Aml, which is an L-type CCB, with an angiotensin (Ang II receptor blocker on diabetic cardiorenal damage in spontaneously type 2 diabetic rats. Seventeen-week-old Otsuka Long-Evans Tokushima Fatty rats were randomly assigned to receive Cil, Aml, valsartan (Val, Cil + Val, Aml + Val, or a vehicle (eight rats per group for 22 weeks. Antihypertensive potencies were nearly equal among the CCB monotherapy groups and the combination therapy groups. The lowering of blood pressure by either treatment did not significantly affect the glycemic variables. However, exacerbations of renal and heart failure were significantly suppressed in rats administered Cil or Val, and additional suppression was observed in those administered Cil + Val. Although Val increased the renin–Ang system, Aml + Val treatment resulted in additional increases in these parameters, while Cil + Val did not show such effects. Furthermore, Cil increased the ratio of Ang-(1–7 to Ang-I, despite the fact that Val and Aml + Val decreased the Ang-(1–7 levels. These actions of Cil + Val might be due to their synergistic inhibitory effect on the activity of the SNS, and on aldosterone secretion through N-type calcium channel antagonism and Ang II

  5. The reasons for triple therapy in stable COPD patients in Japanese clinical practice

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    Miyazaki M

    2015-06-01

    Full Text Available Masaki Miyazaki,1 Hidetoshi Nakamura,1,2 Saeko Takahashi,1 Shotaro Chubachi,1 Mamoru Sasaki,1 Mizuha Haraguchi,1 Hideki Terai,1 Makoto Ishii,1 Koichi Fukunaga,1 Sadatomo Tasaka,1 Kenzo Soejima,1 Koichiro Asano,3 Tomoko Betsuyaku1 On behalf of the Keio COPD Comorbidity Research (K-CCR group 1Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, 2Department of Respiratory Medicine, Saitama Medical University, Saitama, 3Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Kanagawa, Japan Background: Triple combination therapy involving long-acting muscarinic antagonists long-acting β2 agonists, and inhaled corticosteroids has recently become an option for maintenance treatment of COPD. Some add-on clinical trials have reported the benefits of these combinations. However, the process to step up to triple therapy varies for individual cases.Methods: Keio University and affiliated hospitals conducted an observational COPD cohort study, recruiting patients diagnosed as having COPD by pulmonary physicians and those referred for investigation of possible COPD. Their prescription history and clinical course were retrospectively analyzed based on the physicians’ medical records and patient questionnaires. This study was registered with UMIN (UMIN000003470, April 10, 2010.Results: A total of 95 of the 445 COPD patients (21% were treated with inhaled corticosteroids/long-acting β2 agonists/long-acting muscarinic antagonists as maintenance therapy, including 12 in COPD Grade I, 31 in Grade II, 38 in Grade III, and 14 in Grade IV, based on the Global Initiative for Chronic Obstructive Lung Disease spirometric grading. For more than half of the patients on triple therapy, the treatment had been intensified due to unsatisfactory improvement of symptoms, and 32% were treated with triple therapy due to comorbid asthma. In contrast, there were COPD patients whose therapy was

  6. Step-down therapy in well-controlled asthmatic patients using salmeterol xinafoate/fluticasone propionate combination therapy

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    Horiuchi K

    2016-03-01

    Full Text Available Kazuya Horiuchi, Keita Kasahara, Yusuke Kuroda, Haruna Morohoshi, Yosuke Hagiwara, Gen Ishii Respiratory Disease Center, Showa University Northern Yokohama Hospital, Yokohama-shi, Kanagawa-ken, Japan Purpose: A combination therapy with inhaled corticosteroid (ICS and a long-acting β agonist (LABA is the standard treatment for asthmatic patients, and step-down treatment is recommended once control has been achieved. However, little data exist that evaluate the long-term outcomes after step-down treatment. Objective: To compare the long-term outcomes of step-down therapy with ICS/LABA or ICS alone for asthmatic patients who have achieved well-controlled asthma by the ICS (250 µg fluticasone/LABA (50 µg salmeterol combination (SFC, two puffs per day. Patients and methods: We randomized 40 well-controlled patients with asthma receiving SFC (250 µg to two groups; one group of patients received step-down therapy with low-dose SFC (100 µg, two puffs daily and another group of patients received step-down therapy with high-dose fluticasone propionate (FP alone (500 µg, daily. The two groups were monitored over 12 months for changes in asthma control test scores, respiratory function (percent forced expiratory volume in 1 second, maximal expiratory flow rate at 50% of the vital capacity [%FEF50], and maximal expiratory flow rate at 25% of the vital capacity [%FEF25], and the concentration of fractional exhaled nitric oxide. Results: There was no significant difference in the dropout rate between the SFC and FP groups. Low-dose SFC maintained the stability of all parameters over 12 months, whereas the FP group exhibited a rapid 5% decrease in forced expiratory volume in 1 second within 2 months after discontinuation of salmeterol; furthermore, after 10 months, there was a gradual decrease in %FEF50 and %FEF25. Conclusion: This study suggests that a balanced step-down protocol, including both ICS and LABA, is essential in providing long-term stability

  7. UV photofunctionalization promotes nano-biomimetic apatite deposition on titanium

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    Saita M

    2016-01-01

    Full Text Available Makiko Saita,1 Takayuki Ikeda,1,2 Masahiro Yamada,1,3 Katsuhiko Kimoto,4 Masaichi Chang-Il Lee,5 Takahiro Ogawa1 1Division of Advanced Prosthodontics, Weintraub Center for Reconstructive Biotechnology, UCLA School of Dentistry, Los Angeles, CA, USA; 2Department of Complete Denture Prosthodontics, Nihon University School of Dentistry, Yokosuka, Japan; 3Division of Molecular and Regenerative Prosthodontics, Tohoku University Graduate School of Dentistry, Sendai, Miyagi, Japan; 4Department of Prosthodontics and Oral Rehabilitation, 5Yokosuka-Shonan Disaster Health Emergency Research Center and ESR Laboratories, Kanagawa Dental University Graduate School of Dentistry, Yokosuka, Japan Background: Although biomimetic apatite coating is a promising way to provide titanium with osteoconductivity, the efficiency and quality of deposition is often poor. Most titanium implants have microscale surface morphology, and an addition of nanoscale features while preserving the micromorphology may provide further biological benefit. Here, we examined the effect of ultraviolet (UV light treatment of titanium, or photofunctionalization, on the efficacy of biomimetic apatite deposition on titanium and its biological capability.Methods and results: Micro-roughed titanium disks were prepared by acid-etching with sulfuric acid. Micro-roughened disks with or without photofunctionalization (20-minute exposure to UV light were immersed in simulated body fluid (SBF for 1 or 5 days. Photofunctionalized titanium disks were superhydrophilic and did not form surface air bubbles when immersed in SBF, whereas non-photofunctionalized disks were hydrophobic and largely covered with air bubbles during immersion. An apatite-related signal was observed by X-ray diffraction on photofunctionalized titanium after 1 day of SBF immersion, which was equivalent to the one observed after 5 days of immersion of control titanium. Scanning electron microscopy revealed nodular apatite deposition

  8. Aloe sterol supplementation improves skin elasticity in Japanese men with sunlight-exposed skin: a 12-week double-blind, randomized controlled trial

    Directory of Open Access Journals (Sweden)

    Tanaka M

    2016-11-01

    Full Text Available Miyuki Tanaka,1 Yuki Yamamoto,2 Eriko Misawa,1 Kazumi Nabeshima,1 Marie Saito,1 Koji Yamauchi,1 Fumiaki Abe,1 Fukumi Furukawa2 1Functional Food Ingredients Department, Food Ingredients & Technology Institute, Morinaga Milk Industry Co., Ltd., Zama, Kanagawa, 2Department of Dermatology, Wakayama Medical University, Kimiidera, Wakayama, Japan Background/objective: Recently, it was confirmed that the daily oral intake of plant sterols of Aloe vera gel (Aloe sterol significantly increases the skin barrier function, moisture, and elasticity in photoprotected skin. This study aimed to investigate whether Aloe sterol intake affected skin conditions following sunlight exposure in Japanese men. Methods: We performed a 12-week, randomized, double-blind, placebo-controlled study to evaluate the effects of oral Aloe sterol supplementation on skin conditions in 48 apparently healthy men (age range: 30–59 years; average: 45 years. The subjects were instructed to expose the measurement position of the arms to the sunlight outdoors every day for 12 weeks. The skin parameters were measured at 0 (baseline, 4, 8, and 12 weeks. Results: Depending on the time for the revelation of the sunlight, the b* value and melanin index increased and the skin moisture decreased. After taking an Aloe sterol tablet daily for 12 weeks, the skin elasticity index (R2, R5, and R7 levels were significantly higher than the baseline value. There were no differences between the groups in these skin elasticity values. In the subgroup analysis of subjects aged <46 years, the change in the R5 and R7 was significantly higher in the Aloe group than in the placebo group at 8 weeks (P=0.0412 and P=0.0410, respectively. There was a difference in the quantity of sun exposure between each subject, and an additional clinical study that standardizes the amount of ultraviolet rays is warranted. No Aloe sterol intake-dependent harmful phenomenon was observed during the intake period

  9. Use of perfusion index from pulse oximetry to determine efficacy of stellate ganglion block

    Directory of Open Access Journals (Sweden)

    Yamazaki H

    2012-03-01

    Full Text Available Hajime Yamazaki, Junichi Nishiyama, Toshiyasu SuzukiDepartment of Anesthesiology, Surgical Science, Tokai University School of Medicine, Kanagawa, JapanBackground: Stellate ganglion block (SGB is a widely used procedure for treatment of pain in the head and upper body, but the clinical signs used to verify the effectiveness of SGB can be ambiguous or variable in some patients. We observed the chronological changes in perfusion index (PI from pulse oximetry to determine if these changes correlated with the clinical signs associated with an effective SGB. We hypothesized that PI could provide an easy method to assess the effectiveness of SGB.Method: We compared the chronologies in PI on the treated and untreated sides of 21 patients in whom treatment by SGB was found to be effective. The SGB was performed by administering 6 mL of 1% mepivacaine. The effectiveness of the SGB was confirmed on the basis of clinical signs. Additionally, in two patients we tested whether increased PI on the treatment side correlated with increased microcirculation as measured by laser-Doppler blood flowmetry.Results: On the side treated by SGB, PI increased 61.4% in the earlobe and 60.5% from baseline values in the upper limbs, at 5 minutes after initiation of the procedure. Differences in PI before and after treatment were significant at both sites. No time-course increases in PI were found on the untreated side at either site. Following SGB, increases in PI correlated with increases in blood flow as measured by laser-Doppler flowmetry.Conclusion: PI increased in the earlobe and upper limbs on the treated side of 21 patients who received an effective SGB but not on the untreated side. The positive correlations between changes in PI and both presence of clinical signs and changes in blood flow in the skin microcirculation indicate a sympatholytic effect, suggesting that the PI could be useful in determination of the efficacy of SGB.Keywords: stellate ganglion block

  10. Assessment of effects of differences in trunk posture during Fowler’s position on hemodynamics and cardiovascular regulation in older and younger subjects

    Directory of Open Access Journals (Sweden)

    Kubota S

    2017-03-01

    Full Text Available Satoshi Kubota,1 Yutaka Endo,1 Mitsue Kubota,1 Tomohiko Shigemasa2 1School of Nursing and Rehabilitation Sciences at Odawara, International University of Health and Welfare, Odawara, Kanagawa, Japan; 2Department of Cardiology, International University of Health and Welfare Atami Hospital, Atami, Shizuoka, Japan Background: Downward shifts in blood volume with changing position generally cause tachycardic responses. Age-related decreases in vagal nerve activity could contribute to orthostatic hypotension in older individuals. Fowler’s position is a reclined position with the back between 30° and 60°, used to facilitate breathing, eating, and other routine daily activities in frail and elderly patients. Objective: This study examined whether stroke volume (SV was higher and heart rate (HR lower in Fowler’s position with an upright upper trunk than in Fowler’s position with the whole trunk upright in both older and younger subjects, based on the assumption that lower HR would result from reduced sympathetic activation in older individuals. Methods: We assessed hemodynamics and HR variability from electrocardiography, noninvasive arterial pressure and impedance cardiography in 11 younger male subjects (age range, 20–22 years and 11 older male subjects (age range, 64–79 years, using three positions: supine, or Fowler’s positions with either 30° of lower trunk inclination and 60° of upper trunk inclination (UT60 or 60° of whole trunk inclination (WT60. Comparisons were then made between age groups and between positions. Results: Reductions in SV and tachycardic response were smaller with UT60 than with WT60, in both younger and older subjects. In addition, reduced tachycardic response with upright upper trunk appeared attributable to decreased vagal withdrawal in younger subjects and to reduced sympathetic activation in older subjects. Conclusion: Our findings indicate that an upright upper trunk during Fowler’s position allowed

  11. Antistress effects of Kampo medicine "Yokukansan" via regulation of orexin secretion

    Directory of Open Access Journals (Sweden)

    Katahira H

    2017-03-01

    Full Text Available Haruto Katahira,1 Masataka Sunagawa,1 Daishi Watanabe,1,2 Yasuaki Kanada,1,3 Ayami Katayama,1 Risa Yamauchi,1 Masashi Takashima,4 Shintaro Ishikawa,1 Tadashi Hisamitsu1 1Department of Physiology, 2Department of Neurology, School of Medicine, Showa University, 3Department of Surgery, Showa University Koto Toyosu Hospital, Tokyo, 4Department of Orthopaedic Surgery, Showa University Fujigaoka Hospital, Kanagawa, Japan Objective: Various stressors induce stress responses through the hypothalamic–pituitary–adrenal and the sympathetic–adrenal–medullary axes, which are regulated, in part, by orexin. For example, secretion of orexin in the hypothalamus is increased in rats exposed to the stress of social isolation for 1 week. In this study, the antistress effects of Kampo medicine Yokukansan (YKS via the regulation of orexin secretion were investigated using a rat model.Methods and results: The administration of 300 mg/kg per day of YKS to rats for 1 week significantly decreased the plasma orexin levels compared with non-treated rats, whereas the administration of 1,000 mg/kg of YKS had no effect on orexin levels. Therefore, 300 mg/kg of YKS was an effective dose for controlling orexin secretion. Subsequently, rats were divided into group-housed control (Con, individually housed stress (Stress, and individually housed YKS (300 mg/kg-treated stress (Stress + YKS groups. After 1 week, a resident–intruder aggression test was performed, and the plasma levels of orexin and corticosterone were measured. In the Stress group, aggressive behavior and the levels of corticosterone and orexin significantly increased compared with the Con group; however, these effects were inhibited in the Stress + YKS group. Further, an orexin receptor antagonist (TCS 1102; 10 mg/kg was intraperitoneally administered to rats exposed to isolation stress to determine whether orexin was involved in stress responses. Under these conditions, aggressive behavior and the

  12. Relationships between fat deposition in the liver and skeletal muscle and insulin sensitivity in Japanese individuals: a pilot study

    Directory of Open Access Journals (Sweden)

    Eiichi Yoshimura

    2011-01-01

    Full Text Available Eiichi Yoshimura1,2, Hideaki Kumahara3, Takuro Tobina4, Sakiko Matono1, Akira Kiyonaga4, Miyuki Kimura5, Hiroshi Tsukikawa6, Shinya Kono6, Takashi Etou5, Shin Irie5, Keizo Anzai7, Hiroaki Tanaka41Graduate School of Sports and Health Science, Fukuoka University, Fukuoka, Japan; 2Faculty of Medicine, Fukuoka University, Fukuoka, Japan; 3Faculty of Nutrition Sciences, Nakamura Gakuen University, Fukuoka, Japan; 4Faculty of Sports and Health Science, Fukuoka University, Fukuoka, Japan; 5Kyushu Clinical Pharmacology Research Clinic, Fukuoka, Japan; 6PS Clinic, Fukuoka, Japan; 7Saga University Hospital, Saga, JapanPurpose: To evaluate the relationships between insulin sensitivity (IS, body fat accumulation, and aerobic capacity in middle- to older-aged Japanese participants with visceral adiposity.Participants and methods: Aerobic capacity was measured during an incremental ramp exercise test. Computed tomography was used to measure visceral (VFA and subcutaneous (SFA fat area, the fat in liver-to-spleen ratio (L/S, and low-density skeletal muscle area (LDMA. IS was assessed using euglycemic-hyperinsulinemic clamps.Results: A total of 11 males and 9 females, age 58 ± 9 years (mean ± standard deviation, body mass index 29 ± 4.1 kg/m2, and VFA 190 ± 53 cm2 participated in this study. In unadjusted models, VFA, LDMA, and L/S were significantly correlated with IS, which remained in adjusted models for LDMA and L/S, but not for VFA. In multiple stepwise regression analysis including sex, age, body fat, VFA, SFA, alcohol consumption, and aerobic capacity (oxygen uptake at the lactate threshold, L/S, and LDMA accounted for 70% of the total variance in IS. Percentage body fat and SFA, but not VFA, were significantly correlated with high molecular-weight adiponectin levels (r = 0.58, P < 0.01 and r = 0.54, P < 0.05, respectively. IS and L/S were significantly and negatively correlated with tumor necrosis factor-α (r = -0.67 and -0.63, respectively; both P

  13. Factors affecting the pharmacokinetics and pharmacodynamics of PEGylated liposomal irinotecan (IHL-305 in patients with advanced solid tumors

    Directory of Open Access Journals (Sweden)

    Wu H

    2015-02-01

    Full Text Available Huali Wu,1 Jeffrey R Infante,2 Vicki L Keedy,3 Suzanne F Jones,2 Emily Chan,3 Johanna C Bendell,2 Wooin Lee,4 Whitney P Kirschbrown,1 Beth A Zamboni,5 Satoshi Ikeda,6 Hiroshi Kodaira,6 Mace L Rothenberg,3 Howard A Burris III,2 William C Zamboni1,7–9 1UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, 2Sarah Cannon Research Institute/Tennessee Oncology, PLLC, 3Vanderbilt University, Nashville, TN, 4Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY, 5Department of Mathematics, Carlow University, Pittsburgh, PA, USA; 6Yakult Honsha Co., Ltd., Medical Development Department, Tokyo, Japan; 7UNC Lineberger Comprehensive Cancer Center, 8UNC Institute for Pharmacogenomics and Individualized Therapy, 9Carolina Center for Cancer Nanotechology Excellence, University of North Carolina, Chapel Hill, NC, USA Abstract: IHL-305 is a PEGylated liposomal formulation of irinotecan (CPT-11. The objective of this study was to evaluate the factors associated with interpatient variability in the pharmacokinetics and pharmacodynamics of IHL-305 in patients with advanced solid tumors. IHL-305 was administered intravenously once every 4 weeks as part of a Phase I study. Pharmacokinetic studies of the liposomal sum total CPT-11, released CPT-11, SN-38, SN-38G, 7-ethyl-10-[4-N-(5-aminopentanoic acid-1-piperidino]-carbonyloxycamptothecin, and 7-ethyl-10-[4-amino-1-piperidino]-carbonyloxycamptothecin in plasma were performed. Noncompartmental and compartmental pharmacokinetic analyses were conducted using pharmacokinetic data for sum total CPT-11. The pharmacokinetic variability of IHL-305 is associated with linear and nonlinear clearance. Patients whose age and body composition (ratio of total body weight to ideal body weight [TBW/IBW] were greater than the median age and TBW/IBW of the study had a 1.7-fold to 2.6-fold higher ratio of released CPT-11 area under the concentration versus time

  14. Identification of atrophy of the subgenual anterior cingulate cortex, in particular the subcallosal area, as an effective auxiliary means of diagnosis for major depressive disorder

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    Niida A

    2012-08-01

    Full Text Available Akira Niida,1 Richi Niida,2 Hiroshi Matsuda,3 Takashi Inada,4 Makoto Motomura,5 Akihiko Uechi61Department of Radiology, Nanbu Hospital, Itoman City, Okinawa, 2Department of Psychiatry, Nanto Clinic, Urasoe City, Okinawa, 3Department of Nuclear Medicine, Saitama Medical University International Medical Center, Hidaka City, Saitama, 4Department of Psychiatry, Kai Clinic, Naha City, Okinawa, 5Department of Human Sciences, University of the Ryukyu, Nakagami County, Okinawa, 6Cognitive Neuroscience Research Project, Kansai Gaidai University, Hirakata City, Osaka, JapanBackground: Despite being a very common psychiatric disorder, physicians often have difficulty making a diagnosis of major depressive disorder (MDD because, without established diagnostic criteria, they have to depend on interviews with patients and observation to assess psychiatric symptoms. However, previous researchers have reported that magnetic resonance imaging (MRI scans identify morphological changes in the brains of patients with MDD, which inspired us to hypothesize that assessment of local changes in the brain using voxel-based morphometry would serve as an auxiliary diagnostic method for MDD. Therefore, we focused on the VSRAD® plus (voxel-based specific regional analysis system for Alzheimer’s disease, a diagnostic support system for use in early Alzheimer’s disease, which allowed us to identify regional atrophy in the brain easily based on images obtained from MRI scans.Methods: The subjects were 75 patients with MDD, 15 with bipolar disorder, and 30 healthy subjects, aged 54–82 years. First, 1.5 T MRI equipment was used to scan three-dimensional T1-weighted images for the individual subjects, and the imaged data were analyzed by VSRAD advance (voxel-based morphometric software developed for diagnosis of early Alzheimer’s disease. The efficacy of the equipment for diagnosis of MDD was evaluated based on the distribution of atrophy in the subgenual anterior

  15. Renoprotective effects of telmisartan after unilateral renal ablation in rats

    Directory of Open Access Journals (Sweden)

    Matsuo T

    2013-10-01

    Full Text Available Tomohiro Matsuo, Yasuyoshi Miyata, Yuji Sagara, Yoshikazu Higami, Shohei Tobu, Manabu Matsuo, Mitsuru Noguchi, Isao Shimokawa, Hiroshi Kanetake, Hideki Sakai Department of Nephro-Urology, Department of Investigative Pathology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan Purpose: The renoprotective function of the angiotensin II type 1 receptor blocker (ARB is well-known in various studies, including the animal model of renal failure. However, detailed temporal changes of pathological and molecular findings after unilateral nephrectomy are not fully understood. The main purpose of this study was to clarify the renoprotective effects and pathological changes induced by the ARB in rat-remnant kidney (RK tissues after unilateral nephrectomy, but not after a 5/6 nephrectomy. Methods: Telmisartan, which is structurally and functionally unique among ARB, was used in this study. Three rat groups were examined: A no ARB administrated (RK, n=21; B continuous subcutaneous infusion of an ARB administrated (RK-ARB, n=21; and C a sham-operated group (Sham. Renal function was evaluated by blood urea nitrogen (BUN levels and creatinine clearance (Ccr. Fibrosis was evaluated by hydroxyproline levels and Masson's trichrome staining. Expressions of angiotensin II type 1 receptor (AT1R and transforming growth factor beta (TGF-ß were investigated by real-time polymerase chain reaction and Western blotting. Results: There was no significant difference regarding body and kidney weight or pathological features evaluated by hematoxylin and eosin staining between the RK and RK-ARB groups. The Ccr in the RK group was significantly lower than that in the Sham group (P<0.01, but no significant difference was found between the RK-ARB and Sham groups. The fibrotic area increased significantly with time after nephrectomy in the RK group. Although a similar trend was found in the RK-ARB group, the percentage of fibrous area in the RK-ARB group

  16. Tratamiento del Cáncer con captura de Neutrones

    Directory of Open Access Journals (Sweden)

    Jaime Gómez Gonzalez

    1997-12-01

    Full Text Available

    La captura de átomos de boro, gadolinio o la mezcla de estos dos elementos para tratamiento del cáncer es un método experimental que está demostrando gran utilidad en el tratamiento de los tumores cerebrales malignos y de melanomas. Se espera que en un futuro próximo se pueda utilizar en la terapia del cáncer del pulmón, próstata y seno.

    La captura de átomos de boro con neutrones es un método bifásico: Requiere la inyección de una substancia con afinidad por el tejido neoplásico como el boro o el gadolinio y la exposición del enfermo a un haz de neutrones epitérmicos. Al entrar en contacto los neutrones con el boro o gadolinio captado por las células tumorales, se forma una reacción de fisión limitada a un radio de 5 a 10 micras la cual libera una gran cantidad de energía, produce la destrucción de las trenzas de DNA y del tejido tumoral. Las células normales que no captan boro o gadolinio permanecen indemnes.

    Antecedentes


    El método conocido por la sigla inglesa BNCT (Boron Neutron Capture Therapy fue iniciado en Bastan en los años cincuenta por el DI. William Sweet, profesor de neurocirugía de la Universidad de Harvard. Entre 1950 y 1960 se trataron cerca de 50 enfermos con tumores cerebrales malignos. Los resultados no fueron satisfactorios porque el compuesto borado y los neutrones que se utilizaron fueron de baja energía.

    En 1964 Hiroshi Hatanaka, un neurocirujano japonés, trabajó con el DI. Sweet y aprendió el método. A su regreso a Japón en 1967 modificó el sistema con la introducción de un compuesto borado de segunda generación conocido como BSH (borocaptato de sodio. Hatanaka utilizaba la técnica de craneotomía abierta bajo anestesia general y exposición a los neutrones térmicos.

    En 1993 Hatanaka presentó en el Congreso Mundial de Neurocirugía reunido en Acapu1co, México, los resultados de veinticinco años de trabajo y mostr

  17. 二战时期日本左翼作家文学转向问题研究%A Research on the Literary Turn of Japanese Left-wing Writers during World War II

    Institute of Scientific and Technical Information of China (English)

    李俄宪

    2012-01-01

    在日本左翼文学研究领域,二战时期左翼作家的大面积转向问题一直是一个复杂的难题。大多数左翼作家在政府的高压政策和军国主义的残酷镇压下,脱离左翼文学阵营,又大面积发生了左翼作家参加侵略战争、创作战争文学的事实,这在世界左翼文学史上都是罕见的现象。其中火野苇平、上田广、石川达三的战争文学作品,甚至被批判为“侵华文学”、“文学战犯”等等,但如果换一个角度,从左翼作家因素、从文学本体和文本自身的超时空存在来把握的话,虽然这些作品在创作意图、时代环境因素以及战争等当时的社会效果方面属于侵华文学范畴,但其中左翼文学青年早期形成的马克思主义阶级意识和平民意识、作品整体印象上模糊的反战意识,或者可以给清醒的读者留下反思契机。本文主要以左翼作家的战争文学作品为中心,对其创作机制、艺术方法选择及形成进行了探讨。%In the research field of Japancese left-wing literature, the massive-scale turn of the left- wing writers during WWII has always been a complicated issue. One can rarely find in world history of left-wing literature that not only a large number of left-wing writers, because of the high- handed government policy and the merciless suppression of militarism, broke away from left-wing writing, but also a lot of them joined the agreesive war in person, and produced war literature. Among these works, those of Ashihei Hino, Hiroshi Ueda and Ishikawa Tatuzou are even criticized as the "literature of the aggressive war against China", and the writers as "literary war crimi- nals". However, a careful consideration of the left-wing writers, and of the timelessness and ahistoricalness of literary ontology and the literary text itself, provides us with a new perspective into the issue. It' s true that the writing purposes, the social

  18. 民族、国家和全球经济政治的民主治理——世界政治经济学学会第四届论坛综述

    Institute of Scientific and Technical Information of China (English)

    丁晓钦

    2009-01-01

    由世界政治经济学学会和法国加百利·佩鲁基金会联合主办的“民族、国家和全球经济政治的民主治理——世界政治经济学学会第四届论坛”于2009年5月28~29日在法国巴黎隆重举行,来自中国、关国、加拿大、英国、法国、日本、墨西哥、爱尔兰、意大利、德国、奥地利、比利时、土耳其、澳大利亚等14个国家的近百位学者出席了此次论坛。论坛分为开幕式、颁奖仪式、大会发言、分会研讨、闭幕式五个部分。论坛开幕式由世界政治经济学学会副会长、法国马恩河谷大学让一克罗德·迪劳内(Jean~Claude Delaunay)教授主持,世界政治经济学学会会长、中国社会科学院马克思主义研究学部主任、马克思主义研究院院长程恩富教授致开幕词,法国共产党前主席罗伯特·余(Robert Hue)致欢迎词。随后,世界政治经济学学会颁发了首届“21世纪世界政治经济学杰出成果奖”,日本大西广(Hiroshi Ohnishi)教授、德国海因茨·迪特里奇(Heinz Dietrich)教授、中国社会科学院程恩富教授、中南财经政法大学刘思华教授和南京财经大学何干强教授获此殊荣。罗伯特·余和法国加百利·佩鲁基金会主任米歇尔·马索(Michel Maso)为获奖者颁发了奖杯和获奖证书。

  19. Kawasaki disease: A brief history.

    Science.gov (United States)

    Burns, J C; Kushner, H I; Bastian, J F; Shike, H; Shimizu, C; Matsubara, T; Turner, C L

    2000-08-01

    simultaneous recognition of this disease around the world in the 1960s and 1970s. There are several possible explanations. KD may have been a new disease that emerged in Japan and emanated to the Western World through Hawaii, where the disease is prevalent among Asian children. Alternatively, KD and IPN may be part of the spectrum of the same disease and clinically mild KD masqueraded as other diseases, such as scarlet fever in the preantibiotic era. Case reports of IPN from Western Europe extend back to at least the 19th century, but, thus far, cases of IPN have not been discovered in Japan before World War II. Perhaps the factors responsible for KD were introduced into Japan after the World War II and then reemerged in a more virulent form that subsequently spread through the industrialized Western world. It is also possible that improvements in health care and, in particular, the use of antibiotics to treat infections caused by organisms including toxin-producing bacteria reduced the burden of rash/fever illness and allowed KD to be recognized as a distinct clinical entity. Itsuzo Shigematsu, Hiroshi Yanagawa, and colleagues have conducted 14 nationwide surveys in Japan. These have indicated that: 1) KD occurred initially in nationwide epidemics but now occurs in regional outbreaks; 2) there are approximately 5,000 to 6,000 new cases each year; 3) current estimates of incidence rates are 120 to 150 cases per 100,000 children definition based on Kawasaki's original criteria. The Centers for Disease Control and Prevention developed a computerized database in 1984, and a passive reporting system currently exists in 22 states. Regional investigations and national surveys suggest an annual incidence of 4 to 15 cases per 100 000 children <5 years o

  20. Effect of fluid loading with normal saline and 6% hydroxyethyl starch on stroke volume variability and left ventricular volume

    Directory of Open Access Journals (Sweden)

    Kanda H

    2015-09-01

    Full Text Available Hirotsugu Kanda,1 Yuji Hirasaki,2 Takafumi Iida,1 Megumi Kanao,1 Yuki Toyama,1 Takayuki Kunisawa,1 Hiroshi Iwasaki,11Department of Anesthesiology and Critical Care Medicine, Asahikawa Medical University, Asahikawa, 2Department of Anatomy, The Jikei University Graduate School of Medicine, Tokyo, JapanPurpose: The aim of this clinical trial was to investigate changes in stroke volume variability (SVV and left ventricular end-diastolic volume (LVEDV after a fluid bolus of crystalloid or colloid using real-time three-dimensional transesophageal echocardiography (3D-TEE and the Vigileo-FloTrac™ system.Materials and methods: After obtaining Institutional Review Board approval, and informed consent from the research participants, 22 patients undergoing scheduled peripheral vascular bypass surgery were enrolled in the study. The patients were randomly assigned to receive 500 mL of hydroxyethyl starch (HES; HES group, n=11 or normal saline (Saline group, n=11 for fluid replacement therapy. SVV was measured using the Vigileo-FloTrac system. LVEDV, stroke volume, and cardiac output were measured by 3D-TEE. The measurements were performed over 30 minutes before and after the fluid bolus in both groups.Results: SVV significantly decreased after fluid bolus in both groups (HES group, 14.7%±2.6% to 6.9%±2.7%, P<0.001; Saline group, 14.3%±3.9% to 8.8%±3.1%, P<0.001. LVEDV significantly increased after fluid loading in the HES group (87.1±24.0 mL to 99.9±27.2 mL, P<0.001, whereas no significant change was detected in the Saline group (88.8±17.3 mL to 91.4±17.6 mL, P>0.05. Stroke volume significantly increased after infusion in the HES group (50.6±12.5 mL to 61.6±19.1 mL, P<0.01 but not in the Saline group (51.6±13.4 mL to 54.1±12.8 mL, P>0.05. Cardiac output measured by 3D-TEE significantly increased in the HES group (3.5±1.1 L/min to 3.9±1.3 L/min, P<0.05, whereas no significant change was seen in the Saline group (3.4±1.1 L/min to 3.3±1.0 L

  1. Adding thiazide to a rennin-angiotensin blocker regimen to improve left ventricular relaxation in diabetes and nondiabetes patients with hypertension

    Directory of Open Access Journals (Sweden)

    Takami T

    2012-09-01

    Full Text Available Takeshi Takami,1 Hiroshi Ito,2 Katsuhisa Ishii,3 Kenei Shimada,4 Katsuomi Iwakura,5 Hiroyuki Watanabe,6 Shota Fukuda,7 Junichi Yoshikawa81Department of Internal Medicine, Clinic Jingumae, Kashihara, Japan; 2Department of Cardiovascular Medicine, Okayama University, Graduate School of Medicine, Okayama, Japan; 3Department of Cardiology, Kansai Electric Power Hospital, Osaka, Japan; 4Department of Internal Medicine and Cardiology, Osaka City University of Medicine, Osaka, Japan; 5Cardiovascular Center, Sakurabashi Watanabe Hospital, Osaka, Japan; 6Department of Cardiology, Sakakibara Heart Institute, Tokyo, Japan; 7Department of Medicine, Osaka Ekisaikai Hospital, Osaka, Japan; 8Nishinomiya Watanabe Cardiovascular Center, Nishinomiya, JapanAbstract: The urinary albumin to creatinine ratio (UACR is an independent predictor of outcomes in patients with diastolic dysfunction. Thus, we investigated the relationship between diastolic dysfunction, UACR, and diabetes mellitus (DM in the EDEN study. We investigated the effect of switching from an angiotensin-converting enzyme inhibitor (ACEi or angiotensin receptor blocker (ARB to a combination of losartan and hydrochlorothiazide on left ventricular (LV relaxation in patients with hypertension and diastolic dysfunction. We enrolled 106 patients with and 265 patients without DM. All patients had diastolic dysfunction and had not achieved their treatment goals with an ACEi or ARB. The measurements of e′ velocity and E/e′ ratio was performed with echocardiography as markers of LV diastolic function. We switched the ACEi or ARB to losartan/hydrochlorothiazide and followed these patients for 24 weeks. UACR was decreased in patients with DM (123.4 ± 288.4 to 66.5 ± 169.2 mg/g creatinine; P = 0.0024, but not in patients without DM (51.2 ± 181.8 to 39.2 ± 247.9 mg/g creatinine; P = 0.1051. Among DM patients, there was a significant relationship between changes in UACR and changes in e′ velocity (r =

  2. PREFACE: Non-contact AFM Non-contact AFM

    Science.gov (United States)

    Giessibl, Franz J.; Morita, Seizo

    2012-02-01

    Kelvin probe force microscopy for Si surfaces by taking account of chemical forces Masaru Tsukada, Akira Masago and Mamoru Shimizu Reversal of atomic contrast in scanning probe microscopy on (111) metal surfaces M Ondrácek, C González and P Jelínek Mechanical properties of H2Pc self-assembled monolayers at the single molecule level by noncontact atomic force microscopy Han-Qing Mao, Na Li, Xi Chen and Qi-Kun Xue High-resolution imaging of C60 molecules using tuning-fork-based non-contact atomic force microscopy R Pawlak, S Kawai, S Fremy, T Glatzel and E Meyer NC-AFM contrast formation on the calcite (101¯4) surface Philipp Rahe, Jens Schütte and Angelika Kühnle Imaging and manipulation of adatoms on an alumina surface by noncontact atomic force microscopy G H Simon, M Heyde and H-J Freund Three-dimensional scanning force/tunneling spectroscopy at room temperature Yoshiaki Sugimoto, Keiichi Ueda, Masayuki Abe and Seizo Morita Imaging and manipulation of the Si(100) surface by small-amplitude NC-AFM at zero and very low applied biasA Sweetman, R Danza, S Gangopadhyay and P Moriarty Manipulation of individual water molecules on CeO2(111) S Torbrügge, O Custance, S Morita and M Reichling FM-AFM imaging of a commercial polyethylene film immersed in n-dodecaneTakumi Hiasa, Tomoki Sugihara, Kenjiro Kimura and Hiroshi Onishi

  3. Japan-China Joint Medical Workshop on Drug Discoveries and Therapeutics 2008: The need of Asian pharmaceutical researchers' cooperation.

    Science.gov (United States)

    Nakata, M; Tang, W

    2008-10-01

    Design, synthesis and antiviral evaluation of novel heterocyclic compounds as HIV-1 NNRTIs by Xinyong Liu (Shandong University, China) ● Antiviral drug screening from microbial products by Eisaku Tsujii (Astellas Pharma Inc., Japan) ● Viral factors that determine the natural course of chronic hepatitis B viral infection by Hiroshi Yotsuyanagi (The University of Tokyo, Japan) ● Effect of andrographolide derivatives having α-glucosidase inhibition, on HBsAg, HBeAg secretion in HepG2 2.2.15 cells by Hongmin Liu (Zhengzhou University, China) ● Current and future antiviral therapy for influenza by Hideki Asanuma (Tokai University, Japan) ● Establishment of an HIV-based pseudotyping system as a safe model for screening inhibitors on bird flu H5N1 entry by Ying Guo (Peking Union Medical Collegee Chinese Academy of Medical Sciences, China) ● Strategy of discovery for novel antibiotics using silkworm infection model by Hiroshi Hamamoto (The University of Tokyo, Japan) ● Potent neuraminidase inhibitors and anti-inflammatory substances from Chaenomeles speciosa by Li Zhang (Chinese Academy of Medical Sciences and Peking Union Medical College, China) ● High-throughput screening assay for hepatitis C virus helicase inhibitors using fluorescence-quenching phenomenon by Hidenori Tani (Waseda University and National Institute of Advanced Industrial Science and Technology, Japan) Session VI. Biochemistry/Molecular Biology/Pharmacology ● A novel conjugate of low-molecular-weight heparin and Cu,Zn-superoxide dismutase: Study on its mechanism in preventing brain reperfusion injury after ischemia in gerbils by Fengshan Wang (Shandong University, China) ● A novel gene fudoh in SCCmec region regulates the colony spreading ability and virulence in Staphylococcus aureus by Chikara Kaito (The University of Tokyo, Japan) ● Water soluble fluorescent boronic acid sensors for tumor cell-surface saccharide by Hao Fang (Shandong Unviersity, China) ● Molecular characterization

  4. PREFACE: Preface

    Science.gov (United States)

    Ye, Chaohui; Wang, Zhong Lin; Zhou, Bingkun

    2011-02-01

    National Laboratory for Optoelectronics (China)Junqiang Sun, Wuhan National Laboratory for Optoelectronics (China) 4. OPTOELECTRONIC SENSING AND IMAGING (OSI)Editors:Kecheng Yang, Wuhan National Laboratory for Optoelectronics (China)Pengcheng Li, Wuhan National Laboratory for Optoelectronics (China) 5. SOLAR CELLS, SOLID-STATE LIGHTING AND INFORMATION DISPLAY TECHNOLOGIES (SSID)Editors:Hiroshi Amano, Meijo University (Japan)Yibing Cheng, Monash University (Australia)Jinzhong Yu, Institute of Semiconductor, CAS (China)Changqing Chen, Wuhan National Laboratory for Optoelectronics (China)Hongwei Han, Wuhan National Laboratory for Optoelectronics (China)Guoli Tu, Wuhan National Laboratory for Optoelectronics (China) 6. TERA-HERTZ SCIENCE AND TECHNOLOGY (THST)Editors:Jianquan Yao, Tianjin University (China)Shenggang Liu, University of Electronic Science and Technology of China (China)X C Zhang, Rensselaer Polytechnic Institute (USA)Jinsong Liu, Wuhan National Laboratory for Optoelectronics (China) International Advisory Committee:Yibing Cheng, Monash University (Australia)Stephen Z D Cheng, University of Akron (USA)Min Gu, Swinburne University of Technology (Australia)Andrew B Holmes, the University of Melbourne (Australia)Chinlon Lin, Bell Laboratory (retired, USA)Xun Li, McMaster University (Canada)Shenggang Liu, University of Electronic Science and Technology of China (China)Jesper Moerk, Technical University of Denmark (Denmark)Dennis L Matthews, University of California, Davis (USA)Jiacong Shen, Jilin University (China)Ping Shum, Nanyang Technological University (Singapore)Chester C T Shu, Chinese University of Hong Kong (China)Valery V Tuchin, Saratov State University (Russia)Bruce Tromberg, University of California/Irvine (USA)Peiheng Wu, University of Nanjing (China)Alan Willner, University of Southern California (USA)Lihong Wang, Washington University in St. Louis (USA)C P Wong, Georgia Institute of Technology (USA)Jianquan Yao, Tianjin University (China)Xi Zhang

  5. Seeding Experiment of Liquid Carbon Dioxide for Enhancing Winter-time Precipitation in Saga Prefecture,Northern Kyushu,Japan

    Science.gov (United States)

    Wakimizu, K.; Nishiyama, K.; Tomine, K.; Maki, T.; Suzuki, Y.; Morita, O.

    2012-12-01

    Many droughts (shortage of water) have broken out by extreme small amount rainfall in recent Japan. So far,in order to prevent these droughts,artificial rainfall methods with 'AgI' or 'dry ice' have been widely used in Japan. However,these methods have many problems,which a large amount of overcooling liquid in the cumulus cloud was not able to be converted into precipitation efficiently. So as to solve these problems,new artificial rainfall method using liquid carbon dioxide (LC) was proposed by Fukuta (1996). This new method consists of the generation of ice particles by homogeneous nucleation using LC and the subsequent more effective growth for ice particles without competition process. And, this method is called 'Low-Level Penetration Seeding of Homogeneous Ice Nucleant (LOLEPSHIN)' ; this induces a 'Roll-up Expansion of Twin Horizontal Ice-crystal Thermals (RETHIT)' and a subsequent 'Falling growth-Induced Lateral Air Spreading (FILAS)'. This LC method was applied to thin super-cooled cumulus clouds in Saga prefecture, Northern Kyushu, Japan on February 4,2006. The seeding airplane took off the Atugi Airport in Kanagawa Prefecture toward the Iki Island around 0830JST. Many cloud bands were cofirmed in the flight going to the experimental area and the cloud base temperature was approximately -9C (1200m). Scince some young developing thin cumuli were found over the Iki Island, LC seeding to these clouds was carried out two times from 0841JST until 0919JST penetrating the -9C (1200m) altitude. The first precipitation seeding ebded in failure. The second penetration seeding was done for 115 seconds around 0917JST. This penetration led to success of developing one artificial echo (Echo I) in the leeward side of the Iki Island. Eco I moved from NNW to SSW. The maximum area of Echo I were 48km2 (at 1033JST) and first comfirmed by the Kyushu University radar (KU radar) at 1006JST (46 min. after LC seeding) around Mt.Sefuri in Saga Prefecture. It can be inferred that

  6. Maintenance of the paraspinal muscles may protect against radiographic knee osteoarthritis

    Directory of Open Access Journals (Sweden)

    Azuma K

    2017-08-01

    Full Text Available Koichiro Azuma,1 Yasushi Sera,1 Takuma Shinjo,1 Michiyo Takayama,2 Eisuke Shiomi,2 Suketaka Momoshima,2 Yasushi Iwao,2 Hiroyuki Ishida,3 Hideo Matsumoto1 1Institute for Integrated Sports Medicine, Keio University School of Medicine, 2Center for Preventive Medicine, Keio University Hospital, Shinjuku-ku, Tokyo, 3Sports Medicine Research Center, Keio University, Kohoku-ku, Yokohama, Kanagawa, Japan Background: Knee osteoarthritis (OA is an increasing health problem worldwide. So far, only obesity and quadriceps weakness are identified as modifiable risk factors for knee OA. Core muscle strengthening is becoming increasingly popular among older adults because of its ability to enhance the activities of daily living during old age. This study investigated the associations of the size and quality of the abdominal trunk muscles with radiographic knee osteoarthritis (RKOA. Methods: From 2012 to 2016, data were collected from 146 males and 135 females (age 63.9±13.4 years, BMI 23.2±3.8 kg/m2 at annual musculoskeletal examinations, including knee radiographs and body composition analyses, by dual-energy X-ray absorptiometry. Cross-sectional areas of abdominal trunk muscles were measured using a single-slice computed tomography scan image obtained at the level of the umbilicus. Results: The prevalence of RKOA was 21.2% in males and 28.1% in females. Compared to subjects without RKOA, subjects with RKOA were ~6 years older and had smaller paraspinal muscle (38.4±8.7 vs 33.1±10.1 cm2, p<0.01 in males; 24.1±7.1 vs 20.7±7.5 cm2, p<0.05 in females. In contrast, there was no decrease in appendicular or total lean mass, and only in females, BMI and total fat mass (FM were higher in subjects with RKOA (21.5±3.5 vs 24.5±4.4 kg/m2, 16.7±7.0 vs 20.5±7.7 kg, respectively, both p<0.01. After adjusting for age and sex, smaller cross-sectional area/lower attenuation value of the paraspinal muscles was associated with RKOA (both p<0.05, while greater

  7. Dose-ranging pilot randomized trial of amino acid mixture combined with physical activity promotion for reducing abdominal fat in overweight adults

    Directory of Open Access Journals (Sweden)

    Sasai H

    2017-07-01

    Full Text Available Hiroyuki Sasai,1–3,* Keisuke Ueda,4,5,* Takehiko Tsujimoto,6,7 Hiroyuki Kobayashi,1 Chiaki Sanbongi,4 Shuji Ikegami,4 Yoshio Nakata1 1Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, 2Japan Society for the Promotion of Science, Chiyoda, Tokyo, 3Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Meguro, Tokyo, 4Food Science Research Laboratories, Meiji Co., Ltd., Odawara, Kanagawa, 5Graduate School of Comprehensive Human Sciences, 6Faculty of Health and Sport Sciences, University of Tsukuba, Tsukuba, Ibaraki, 7Faculty of Human Sciences, Shimane University, Matsue, Shimane, Japan *These authors contributed equally to this work Objective: The objective of this study was to determine the effective dose of an amino acid mixture comprising arginine, alanine, and phenylalanine combined with physical activity promotion in reducing abdominal fat among overweight adults.Methods: A 12-week randomized, double-blind, placebo-controlled, dose-ranging, pilot trial was conducted in Mito, Japan, from January through April 2016, and the data were analyzed from May through November 2016. The study participants were 35 overweight adults, aged 20–64 years, with no regular exercise habit. Participants were randomly assigned to high-dose (3,000 mg/d, n=9, medium-dose (1,500 mg/d, n=9, low-dose (750 mg/d, n=8, or placebo (0 mg/d, n=9 groups, and the test beverage containing the amino acid mixture or placebo was administered for 12 weeks. All participants maintained a physically active lifestyle during the study period through monthly physical activity promotion sessions and smartphone-based self-monitoring with wearable trackers. Primary outcomes were changes in abdominal total, subcutaneous, and visceral fat areas, assessed by computed tomography.Results: Of the 35 enrolled participants, 32 completed the 12-week follow-up visit. The intention-to-treat analysis revealed that the changes in abdominal total fat

  8. Social Experiments in Tokyo Metropolitan Area Convection Study for Extreme Weather Resilient Cities(TOMACS)

    Science.gov (United States)

    Tsuyoshi, Nakatani; Nakamura, Isao; MIsumi, Ryohei; Shoji, Yoshinori

    2015-04-01

    Introduction TOMACS research project has been started since 2010 July in order to develop the elementary technologies which are required for the adaptation of societies to future global warming impacts that cannot be avoided by the reduction of greenhouse gases. In collaboration with related government institutions, local governments, private companies, and residents, more than 25 organizations and over 100 people are participated. TOMACS consists of the following three research themes: Theme 1: Studies on extreme weather with dense meteorological observations Theme 2: Development of the extreme weather early detection and prediction system Theme 3: Social experiments on extreme weather resilient cities Theme 1 aims to understand the initiation, development, and dissipation processes of convective precipitation in order to clarify the mechanism of localized heavy rainfall which are potential causes of flooding and landslides. Theme 2 aims to establish the monitoring and prediction system of extreme phenomena which can process real-time data from dense meteorological observation networks, advanced X-band radar network systems and predict localized heavy rainfalls and strong winds. Through social experiments, theme 3 aims to establish a method to use information obtained by the monitoring system of extreme phenomena to disaster prevention operations in order to prevent disasters and reduce damage. Social Experiments Toyo University is the core university for the social experiments accomplishment. And following organizations are participating in this research theme: NIED, the Tokyo Metropolitan Research Institute for Environmental Protection (TMRIEP), University of Tokyo, Tokyo Fire Department (TFD), Edogawa Ward in Tokyo, Yokohama City, Fujisawa City and Minamiashigara City in Kanagawa, East Japan Railway Company, Central Japan Railway Company, Obayashi Corporation, and Certified and Accredited Meteorologists of Japan(CAMJ). The social experiments have carried out

  9. EDITORIAL: Focus on Iron-Based Superconductors FOCUS ON IRON-BASED SUPERCONDUCTORS

    Science.gov (United States)

    Hosono, Hideo; Ren, Zhi-An

    2009-02-01

    -L Drechsler, N Kozlova, M Bartkowiak, J E Hamann-Borrero, G Behr, K Nenkov, H-H Klauss, H Maeter, A Amato, H Luetkens, A Kwadrin, R Khasanov, J Freudenberger, A Köhler, M Knupfer, E Arushanov, H Rosner, B Büchner and L Schultz Low-energy spin dynamics in the antiferromagnetic phase of CaFe2As2 N J Curro, A P Dioguardi, N ApRoberts-Warren, A C Shockley and P Klavins Muon spin rotation study of magnetism and superconductivity in BaFe2-xCoxAs2 and Pr1-xSrxFeAsO C Bernhard, A J Drew, L Schulz, V K Malik, M Rössle, Ch Niedermayer, Th Wolf, G D Varma, G Mu, H-H Wen, H Liu, G Wu and X H Chen Magnetic impurities in the pnictide superconductor Ba1-xKxFe2As2 Sutirtha Mukhopadhyay, Sangwon Oh, A M Mounce, Moohee Lee, W P Halperin, N Ni, S L Bud'ko, P C Canfield, A P Reyes and P L Kuhns Neutron scattering investigation of the magnetic order in single crystalline BaFe2As2 M Kofu, Y Qiu, Wei Bao, S-H Lee, S Chang, T Wu, G Wu and X H Chen An NMR study on the F-doping evolution of the iron oxypnictide LaFeAs(O1-xFx) Y Nakai, S Kitagawa, K Ishida, Y Kamihara, M Hirano and H Hosono The peculiar physical properties and phase diagram of BaFe2-xCoxAs2 single crystals X F Wang, T Wu, G Wu, R H Liu, H Chen, Y L Xie and X H Chen Synthesis of LnFeAsO1-y superconductors (Ln=La and Nd) using the high-pressure technique Kiichi Miyazawa, Kunihiro Kihou, Motoyuki Ishikado, Parasharam M Shirage, Chul-Ho Lee, Nao Takeshita, Hiroshi Eisaki, Hijiri Kito and Akira Iyo Correlation effects in the iron pnictides Qimiao Si, Elihu Abrahams, Jianhui Dai and Jian-Xin Zhu Competition/coexisitence of magnetism and superconductivity in iron pnictides probed by muon spin rotation Soshi Takeshita and Ryosuke Kadono Impurity-induced in-gap state and Tc in sign-reversing s-wave superconductors: analysis of iron oxypnictide superconductors Yuko Senga and Hiroshi Kontani Intrinsic magnetic properties of the superconductor NdFeAsO0.9F0.1 from local and global measurements R Prozorov, M E Tillman, E D Mun and P C Canfield

  10. EDITORIAL: Selected papers from the 10th International Workshop on Micro and Nanotechnology for Power Generation and Energy Conversion Applications (PowerMEMS 2010) Selected papers from the 10th International Workshop on Micro and Nanotechnology for Power Generation and Energy Conversion Applications (PowerMEMS 2010)

    Science.gov (United States)

    Reynaerts, Dominiek; Vullers, Ruud

    2011-10-01

    collaboration with the staff of IOP Publishing. PowerMEMS 2010 contents Harvesting energy from airflow with a michromachined piezoelectric harvester inside a Helmholtz resonator S P Matova, R Elfrink, R J M Vullers and R van Schaijk Analysis and characterization of triangular electrode structures for electrostatic energy harvestingDaniel Hoffmann, Bernd Folkmer and Yiannos Manoli A smart and self-sufficient frequency tunable vibration energy harvesterC Eichhorn, R Tchagsim, N Wilhelm and P Woias Power output enhancement of a vibration-driven electret generator for wireless sensor applicationsTatsuakira Masaki, Kenji Sakurai, Toru Yokoyama, Masayo Ikuta, Hiroshi Sameshima, Masashi Doi, Tomonori Seki and Masatoshi Oba Harvesting traffic-induced vibrations for structural health monitoring of bridgesT V Galchev, J McCullagh, R L Peterson and K Najafi Dispenser-printed planar thick-film thermoelectric energy generatorsA Chen, D Madan, P K Wright and J W Evans Silicon nanowire arrays as thermoelectric material for a power microgeneratorD Dávila, A Tarancón, M Fernández-Regúlez, C Calaza, M Salleras, A San Paulo and L Fonseca A micro thermal switch with a stiffness-enhanced thermal isolation structureTakashiro Tsukamoto, Masayoshi Esashi and Shuji Tanaka A dielectric liquid contact thermal switch with electrowetting actuationA R McLanahan, C D Richards and R F Richards A self-regulating valve for single-phase liquid cooling of microelectronicsRadu Donose, Michaël De Volder, Jan Peirs and Dominiek Reynaerts A MEMS-enabled 3D zinc-air microbattery with improved discharge characteristics based on a multilayer metallic substructureA Armutlulu, Y Fang, S H Kim, C H Ji, S A Bidstrup Allen and M G Allen Design, fabrication and testing of an air-breathing micro direct methanol fuel cell with compound anode flow fieldLuwen Wang, Yufeng Zhang, Youran Zhao, Zijiang An, Zhiping Zhou and Xiaowei Liu A shadow-mask evaporated pyroMEMS igniterD A de Koninck, D Briand and N F de Rooij Aerodynamic

  11. Water Fountains in the Sky: Streaming Water Jets from Aging Star Provide Clues to Planetary-Nebula Formation

    Science.gov (United States)

    2002-06-01

    Astronomers using the National Science Foundation's Very Long Baseline Array (VLBA) radio telescope have found that an aging star is spewing narrow, rotating streams of water molecules into space, like a jerking garden hose that has escaped its owner's grasp. The discovery may help resolve a longstanding mystery about how the stunningly beautiful objects called planetary nebulae are formed. Artist's Conception of W43A. Artist's conception of W43A, with the aging star surrounded by a disk of material and a precessing, twisted jet of molecules streaming away from it in two directions. Credit: Kirk Woellert/National Science Foundation. The astronomers used the VLBA, operated by the National Radio Astronomy Observatory, to study a star called W43A. W43A is about 8,500 light-years from Earth in the direction of the constellation Aquila, the eagle. This star has come to the end of its normal lifetime and, astronomers believe, is about to start forming a planetary nebula, a shell of brightly glowing gas lit by the hot ember into which the star will collapse. "A prime mystery about planetary nebulae is that many are not spherical even though the star from which they are ejected is a sphere," said Phillip Diamond, director of the MERLIN radio observatory at Jodrell Bank in England, and one of the researchers using the VLBA. "The spinning jets of water molecules we found coming from this star may be one mechanism for producing the structures seen in many planetary nebulae," he added. The research team, led by Hiroshi Imai of Japan's National Astronomical Observatory (now at the Joint Institute for VLBI in Europe, based in the Netherlands), also includes Kumiko Obara of the Mizusawa Astrogeodynamics Observatory and Kagoshima University; Toshihiro Omodaka, also of Kagoshima University; and Tetsuo Sasao of the Japanese National Astronomical Observatory. The scientists reported their findings in the June 20 issue of the scientific journal Nature. As stars similar to our Sun

  12. Structure, function, and evolution of bacterial ATP-binding cassette systems

    Energy Technology Data Exchange (ETDEWEB)

    Davidson, A.L.; Dassa, E.; Orelle, C.; Chen, J. (Purdue)

    2010-07-27

    The ATP-binding cassette (ABC) systems constitute one of the largest superfamilies of paralogous sequences. All ABC systems share a highly conserved ATP-hydrolyzing domain or protein (the ABC; also referred to as a nucleotide-binding domain [NBD]) that is unequivocally characterized by three short sequence motifs (Fig. 1): these are the Walker A and Walker B motifs, indicative of the presence of a nucleotide-binding site, and the signature motif, unique to ABC proteins, located upstream of the Walker B motif (426). Other motifs diagnostic of ABC proteins are also indicated in Fig. 1. The biological significance of these motifs is discussed in Structure, Function, and Dynamics of the ABC. ABC systems are widespread among living organisms and have been detected in all genera of the three kingdoms of life, with remarkable conservation in the primary sequence of the cassette and in the organization of the constitutive domains or subunits (203, 420). ABC systems couple the energy of ATP hydrolysis to an impressively large variety of essential biological phenomena, comprising not only transmembrane (TM) transport, for which they are best known, but also several non-transport-related processes, such as translation elongation (62) and DNA repair (174). Although ABC systems deserve much attention because they are involved in severe human inherited diseases (107), they were first discovered and characterized in detail in prokaryotes, as early as the 1970s (13, 148, 238, 468). The most extensively analyzed systems were the high-affinity histidine and maltose uptake systems of Salmonella enterica serovar Typhimurium and Escherichia coli. Over 2 decades ago, after the completion of the nucleotide sequences encoding these transporters in the respective laboratories of Giovanna Ames and Maurice Hofnung, Hiroshi Nikaido and colleagues noticed that the two systems displayed a global similarity in the nature of their components and, moreover, that the primary sequences of MalK and

  13. PREFACE: International Conference on Computing in High Energy and Nuclear Physics (CHEP 2010)

    Science.gov (United States)

    Lin, Simon C.; Shen, Stella; Neufeld, Niko; Gutsche, Oliver; Cattaneo, Marco; Fisk, Ian; Panzer-Steindel, Bernd; Di Meglio, Alberto; Lokajicek, Milos

    2011-12-01

    & Genoa University/INFN, Switzerland Lothar Bauerdick, Fermilab, USA Ian Bird, CERN, Switzerland Amber Boehnlein, US Department of Energy, USA Kors Bos, CERN, Switzerland Federico Carminati, CERN, Switzerland Philippe Charpentier, CERN, Switzerland Gang Chen, Institute of High Energy Physics, China Peter Clarke, University of Edinburgh, UK Michael Ernst, Brookhaven National Laboratory, USA David Foster, CERN, Switzerland Merino Gonzalo, CIEMAT, Spain John Gordon, STFC-RAL, UK Volker Guelzow, Deutsches Elektronen-Synchrotron DESY, Hamburg, Germany John Harvey, CERN, Switzerland Frederic Hemmer, CERN, Switzerland Hafeez Hoorani, NCP, Pakistan Viatcheslav Ilyin, Moscow State University, Russia Matthias Kasemann, DESY, Germany Nobuhiko Katayama, KEK, Japan Milos Lokajícek, FZU Prague, Czech Republic David Malon, ANL, USA Pere Mato Vila, CERN, Switzerland Mirco Mazzucato, INFN CNAF, Italy Richard Mount, SLAC, USA Harvey Newman, Caltech, USA Mitsuaki Nozaki, KEK, Japan Farid Ould-Saada, University of Oslo, Norway Ruth Pordes, Fermilab, USA Hiroshi Sakamoto, The University of Tokyo, Japan Alberto Santoro, UERJ, Brazil Jim Shank, Boston University, USA Alan Silverman, CERN, Switzerland Randy Sobie , University of Victoria, Canada Dongchul Son, Kyungpook National University, South Korea Reda Tafirout , TRIUMF, Canada Victoria White, Fermilab, USA Guy Wormser, LAL, France Frank Wuerthwein, UCSD, USA Charles Young, SLAC, USA

  14. Preface

    Science.gov (United States)

    Gauthier, Jean-Claude; Hammel, Bruce; Azechi, Hiroshi; Labaune, Christine

    2006-06-01

    and the Teller lectures. The keynotes give an overview of progress in inertial fusion in North America, Europe and Asia. The Teller lectures show the contributions of this year's two winners: Joe Kilkenny of General Atomics and Max Tabak of LLNL. The remainder of the Proceedings is divided into three parts. Part A covers the physics of inertial fusion; Part B covers facilities, lasers, particle beams, Z-pinches, target fabrication and reactor design; Part C covers fundamental high-energy density science and other applications of inertial fusion VI technology such as plasma diagnostics, atomic physics and X-ray sources, laboratory astrophysics and laser particle acceleration. The readers should be aware that for some of the papers, only a short version is presented in this book: the extended version will be published in a topical issue of the European Physical Journal. The IFSA International Organizing Committee and Scientific Advisory Board appreciate the efforts of inertial fusion researchers worldwide in making IFSA 2005 an extremely successful conference. Jean-Claude Gauthier, technical committee co-chair Bruce Hammel, technical committee co-chair Hiroshi Azechi, technical committee co-chair Christine Labaune, proceedings co-editor

  15. Message from the Editor

    Science.gov (United States)

    Stambaugh, Ronald D.

    2014-01-01

    thank the following outgoing Board Members whose term of service was reached at the end of 2012: Keith Burrell, Atsushi Fukuyama, Guenter Janeschitz, Myeun Kwon, Alberto Loarte, Derek Stork, Tony Taylor and Kazuo Toi. We welcome the new Board Members who have joined the Board from the start of 2013: Pietro Barabaschi, Riccardo Betti, Rich Callis, Wonho Choi, Yasuaki Kishimoto, Joaquin Sánchez, Paul Thomas, Mickey Wade, Howard Wilson, Hiroshi Yamada and Steve Zinkle. We look forward to working with the Board to maintain the high standing of Nuclear Fusion . The Nuclear Fusion office and IOP Publishing Just as the journal depends on the authors, referees, and Board of Editors, so its success is also due to the tireless and largely unsung efforts of the IAEA Nuclear Fusion office in Vienna and IOP Publishing in Bristol. I would like to express my personal thanks to the team for the support that they have given to me, the authors and the referees. Season's greetings I would like to wish our readers, authors, referees, Board of Editors, and Vienna and Bristol office staff season's greetings and thank them for their contributions to Nuclear Fusion in 2013. References [1] Whyte D.G. et al 2010 I-mode: an H-mode energy confinement regime with L-mode particle transport in Alcator C-Mod Nucl. Fusion 50 105005 [2] Bosch H.-S. et al 2013 Technical challenges in the construction of the steady-state stellarator Wendelstein 7-X Nucl. Fusion 53 126001 [3] Chapman I.T. et al 2013 Power requirements for electron cyclotron current drive and ion cyclotron resonance heating for sawtooth control in ITER Nucl. Fusion 53 066001 [4] Knaster J. et al 2013 IFMIF: overview of the validation activities Nucl. Fusion 53 116001

  16. EDITORIAL: Focus on Heavy Ions in Biophysics and Medical Physics FOCUS ON HEAVY IONS IN BIOPHYSICS AND MEDICAL PHYSICS

    Science.gov (United States)

    Durante, Marco

    2008-07-01

    include carcinogenesis, late degenerative tissue effects (including damage to the central nervous system), and hereditary effects. For these studies, microbeams represent an essential tool, considering that in space each cell in the human body will not experience more than one heavy-ion traversal. Both NASA and ESA are investing important resources in ground-based space radiation research programs, to reduce risk uncertainty and to develop countermeasures. For both cancer therapy and space radiation protection a better understanding of the effects of energetic heavy ions is needed. Physics should be improved, especially the measurements of nuclear fragmentation cross-sections, and the transport calculations. Biological effects need to be studied in greater detail, and clearly only understanding the mechanisms of heavy-ion induced biological damage will reduce the uncertainty on late effects in humans. This focus issue of New Journal of Physics aims to provide the state-of-the-art of the biophysics of energetic heavy ions and to highlight the areas where more research is urgently needed for therapy and the space program. Focus on Heavy Ions in Biophysics and Medical Physics Contents Heavy ion microprobes: a unique tool for bystander research and other radiobiological applications K O Voss, C Fournier and G Taucher-Scholz Heavy ions light flashes and brain functions: recent observations at accelerators and in spaceflight L Narici Clinical advantages of carbon-ion radiotherapy Hirohiko Tsujii, Tadashi Kamada, Masayuki Baba, Hiroshi Tsuji, Hirotoshi Kato, Shingo Kato, Shigeru Yamada, Shigeo Yasuda, Takeshi Yanagi, Hiroyuki Kato, Ryusuke Hara, Naotaka Yamamoto and Junetsu Mizoe Heavy-ion effects: from track structure to DNA and chromosome damage F Ballarini, D Alloni, A Facoetti and A Ottolenghi Shielding experiments with high-energy heavy ions for spaceflight applications C Zeitlin, S Guetersloh, L Heilbronn, J Miller, N Elkhayari, A Empl, M LeBourgeois, B W Mayes, L Pinsky

  17. Guest Editorial

    Directory of Open Access Journals (Sweden)

    Jian Cao

    2010-01-01

    reenter method is simple and effective. In “A Programmable Architecture for Layered Multimedia Streams in IPv6 Networks”, B. McAllister et al introduces programmable network functionality (PNF into QoS-enabled IPv6 networks. They integrate FPGA-based hardware devices into intermediate network devices. Thus improves efficiency and flexibility in multimedia transmission. Security is always an unavoidable issue in network and its application. In “Novel Stream Cipher Using SCAN and Variable Ordered Recursive CA Substitutions and Its DSP+FPGA Implementation”, R. J. Chen et al presents a new method of stream cipher using 2-D hybrid cellular automata (CA. The scanning pattern for the CA is generated using an image pre-processing language (SCAN from a short set of primitives. The hardware implementation of DSP plus FPGA is feasible and helpful for image security. In “A Novel Data Mining-Based Method for Alert Reduction and Analysis”, X. Fu et al gives a novel data mining-based method for alert reduction and analysis. They build a real-time framework to filter false IDS alerts using outlier detection. The prototype enhances the efficiency for handling IDS alerts.We believe that this Special Issue will contribute to enhancing knowledge in many diverse areas of the network and parallel computing. In addition, we also hope that the presented results will stimulate further research in these areas.The editors wish to acknowledge the great efforts of many people who helped with this Special Issue. We thank the following reviewers for their tireless efforts in completing the reviews in a short period of time without compromising quality: Haibin Kan,Azman Osman Lim, Xinbin Wang, Hiroshi Mineno, Wenbo Zhu, Kai Liu, Yang Xiang, Zhiming Zhao, Jianxun Liu, Jiachun Wang, Yanmin Zhu and Feilong Tang. We also thank Mrs. George J. Sun, the Executive Editor-in-Chief of JNW for his continued encouragement, guidance and support in the preparation of this issue.

  18. PREFACE: International Conference on Computing in High Energy and Nuclear Physics (CHEP 2012)

    Science.gov (United States)

    Ernst, Michael; Düllmann, Dirk; Rind, Ofer; Wong, Tony

    2012-12-01

    Wisconsin-Madison, United States Günter Duckeck, Ludwig Maximilian University of Munich, Germany Richard Dubois, SLAC, United States Michael Ernst, BNL, United States Ian Fisk, Fermilab, United States Gonzalo Merino, PIC, Spain John Gordon, STFC-RAL, United Kingdom Volker Gülzow, DESY, Germany Frederic Hemmer, CERN, Switzerland Viatcheslav Ilyin, Moscow State University, Russia Nobuhiko Katayama, KEK, Japan Alexei Klimentov, BNL, United States Simon C. Lin, Academia Sinica, Taiwan Milos Lokajícek, FZU Prague, Czech Republic David Malon, ANL, United States Pere Mato Vila, CERN, Switzerland Mauro Morandin, INFN CNAF, Italy Harvey Newman, Caltech, United States Farid Ould-Saada, University of Oslo, Norway Ruth Pordes, Fermilab, United States Hiroshi Sakamoto, University of Tokyo, Japan Alberto Santoro, UERJ, Brazil Jim Shank, Boston University, United States Dongchul Son, Kyungpook National University, South Korea Reda Tafirout, TRIUMF, Canada Stephen Wolbers, Fermilab, United States Frank Wuerthwein, UCSD, United States

  19. La Medicina en el Japón

    Directory of Open Access Journals (Sweden)

    Fernando Serpa Florez

    1993-12-01

    del esquistosomajaponés … Aprendimos a respetar sus nombres desde nuestros tiempos de estudiantes y repetimos las palabras japonesas de enfermedades como las fiebres de Namukayamí, de Sakushu, de Tsutsugamushi, que nuestros maestros de enfermedades tropicales nos enseñaban en la geografía del saber y que hoy llegan plenos de nostalgia en esta cordial evocación nipona, tal el Sodo-Ku, la fiebre por mordedura de rata, cuyo primer caso diagnosticado en Colombia sirvió para que se abrieran a mi’padre, hace más de medio siglo, las puertas de la Academia Nacional de Medicina.

    Hoy, a 3ímismo, la tecnología y la terapéutica de los japoneses, puestas al servicio de la humanidad y sus universidades y escuelas médicas generosamente dispuestas a los investigadores del mundo, así como la labor del actual director de la Organización Mundial de la Salud Hiroshi Nakajima, hacen que el país del sol naciente derrame su esplendor benéfico. Soy testigo de este esfuerzo, como colaborador de la Universidad de Harvard en la difusión del programa Takemi en salud pública internacional. Sea esta ocasión, Señor Embajador, de rendir tributo a la ciencia de su país.

    Un campo especial ha constituido para los médicos el estudio y la admonición de los terribles efectos que las radiaciones ionizantes producen en el hombre o Hiroshima y Nagasaki son ciudades que para nosotros tienen el mismo eco estremecido de las ciudades santas, como Jerusalén en la historia … La asociación de “Médicos Colombianos para la Prevención de la Guerra Nuclear”, filial de la galardonada con el Premio Nobel de la Paz “Organización Internacional para la Prevención de la Guerra Nuclear” (“IPPNW”, cuya Secretaría Ejecutiva tengo el privilegio de desempeñar en nuestro país, ha tenido como meta luchar en todos los campos contra la proliferación de las armas nucleares y la prevención de un holocausto atómico...

  20. Emergency warning system for atmospheric environmental pollution accidents—its construction and application%突发性大气环境污染事件应急预警技术开发及应用

    Institute of Scientific and Technical Information of China (English)

    黄昕; 李蒙蒙; 张振州; 宋宇; 蔡旭辉; 张宏升; 康凌

    2012-01-01

    This paper intends to introduce an emergency warning system for the atmospheric environmental pollution accidents we have developed in this paper. The purpose of our warning system is to meet the needs of our country and the world to predict and warn the ever-increasing occurence of unexpected atmospheric environmental pollution accidents due to the mushrooming of nuclear power and chemical enterprises in recent decades which have brought about abrupt changes in the spatial distribution and temporal variation of hazardous gases or dusty particles and result in WRF (the mesoscale weather forecasting model), CALMET (a diagnostic 3-dimensional meteorological model) and CALPUFF ( an air quality dispersion model) . These models have shown excellent performance while simulating the nuclear accidents at the Fukushima Daiichi nuclear power plant in the middle of March, 2011. In our paper, we have modeled the release, transportation and diffusion processes of Cs - 137 (caesium-137) by using this WRF - CALMET - CALPUFF system for five days, from 12th March to 16th March. During the period of nuclear accident, Cs - 137 was released into atmosphere with time-specific emission rate based on the study of the accident conditions. The peak value of the warning tends to appear from 6:00 to 11:00 a.m. on 15th Mar. According to the radiation monitoring results in various prefectures in Japan, no radioactive emissions were detected during 12 - 14th Mar. The environmental radio level in Tokyo, Chiba, Gunma, and Kana-gawa would turn up dramatically in 5:00 - 10:00 a.m. on 15th Mar. Meteorological field and Cs - 137 transport and deposition were simulated and compared with Japanese observed data, and then we have made our evaluation of the model performance. The result we have worked out helps to find that it is in nice accord with the monitoring dataset, both in area-specific arrival time of Cs - 137 and the coverage at specific times. Thus can be seen that our emergency warning system

  1. Milky Way's super-efficient particle accelerators caught in the act

    Science.gov (United States)

    2009-06-01

    /JAXA Department of High Energy Astrophysics, Kanagawa, Japan), S. Funk (Kavli Institute for Particle Astrophysics and Cosmology, Stanford, USA), P. Ghavamian (Space Telescope Science Institute, Baltimore, USA), K. J. van der Heyden (University of Cape Town, South Africa), and R. Yamazaki (Department of Physical Science, Hiroshima University, Japan). C.G. Bassa is also affiliated with the Radboud University Nijmegen, the Netherlands. ESO, the European Southern Observatory, is the foremost intergovernmental astronomy organisation in Europe and the world's most productive astronomical observatory. It is supported by 14 countries: Austria, Belgium, the Czech Republic, Denmark, France, Finland, Germany, Italy, the Netherlands, Portugal, Spain, Sweden, Switzerland and the United Kingdom. ESO carries out an ambitious programme focused on the design, construction and operation of powerful ground-based observing facilities enabling astronomers to make important scientific discoveries. ESO also plays a leading role in promoting and organising cooperation in astronomical research. ESO operates three unique world-class observing sites in Chile: La Silla, Paranal and Chajnantor. At Paranal, ESO operates the Very Large Telescope, the world's most advanced visible-light astronomical observatory. ESO is the European partner of a revolutionary astronomical telescope ALMA, the largest astronomical project in existence. ESO is currently planning a 42-metre European Extremely Large optical/near-infrared Telescope, the E-ELT, which will become "the world's biggest eye on the sky".

  2. EDITORIAL: Message from the Editor Message from the Editor

    Science.gov (United States)

    Thomas, Paul

    2010-02-01

    award was Steven A. Sabbagh et al for the paper entitled 'Resistive wall stabilized operation in rotating high beta NSTX plasmas' (Nucl. Fusion 46 635-644). Reviews Last year I announced a revival of Nuclear Fusion Reviews, following a decision by the Board of Editors. 'A review of zonal flow experiments', by Akihide Fujisawa was the first fruit of this. In 2010, we are expecting to publish further review articles, the first of which is entitled 'Gyrokinetic simulations of turbulent transport' by Xavier Garbet, Yasuhiro Idomura, Laurent Villard and Tomo-Hiko Watanabe. Letters At the 2009 Board of Editors Meeting in Atlanta, the current letters procedure was summarized and it was noted that the peer review time for Letters is quite variable. Some are accepted within a month of submission, others take longer. Since the purpose of Letters is to provide a route for rapid communication, this is quite an important matter. It was agreed that the Board of Editors would play a more active role in the Letter approval process. If a reviewer asks for a second revision the Editor or a Board of Editors member will be queried as to whether the submission should still be treated as a Letter rather than a regular Paper. The Board of Editors The following Board of Editors members reached the end of their term in 2009: Amanda Hubbard, Yaroslav Kolesnichenko, Kunioki Mima, Boris Sharkov and Michael Ulrickson. On behalf of the Nuclear Fusion Office and the Chairman of the Board of Editors, Mitsuru Kikuchi, I would like to thank them for their efforts in support of the journal. At the same time, we welcomed: Hiroshi Azechi, Xuru Duan, Richard Hawryluk, Sergey Konovalov, Bruce Lipschultz, Peter Norreys, Francesco Romanelli, Tony Taylor and Hartmut Zohm. I am sure that such an illustrious group does not need any introduction to the readers of Nuclear Fusion and I am confident that the new members can only further the success of the journal. It is with great sadness that I have to note the

  3. PREFACE: Fourth Meeting on Constrained Dynamics and Quantum Gravity

    Science.gov (United States)

    Cadoni, Mariano; Cavaglia, Marco; Nelson, Jeanette E.

    2006-04-01

    , France) Michael Mueller (Sardinien.com, Cagliari, Italy) Mario Nadalini (Università di Trento, Italy) José Navarro-Salas (Universidad de Valencia, Spain) Jeanette E. Nelson (Università di Torino, Italy) Alexander Nesterov (Universidad de Guadalajara, Mexico) Hermann Nicolai (Albert-Einstein-Institut, Golm, Germany) Daniele Oriti (DAMTP, University of Cambridge, UK) Marcello Ortaggio (Charles University, Prague, Czech Republic) Silvio Pallua (University of Zagreb, Croatia) Matej Pavsic (Jozef Stefan Institute, Ljubljana, Slovenia) Wlodzimierz Piechocki (Soltan Inst. for Nuclear Studies, Warsaw, Poland) Nicola Pinamonti (Università di Trento, Italy) J. Brian Pitts (University of Notre Dame, Indiana, USA) Vojtech Pravda (Academy of Sciences, Praha, Czech Rep.) Gianpaolo Procopio (DAMTP, University of Cambridge, UK) Alice Rogers (King's College London, UK) Efrain Rojas (Universidad Veracruzana, Mexico) James Ryan (DAMTP, University of Cambridge, UK) Augusto Sagnotti (Università di Roma Tor Vergata, Italy) Wenceslao Santiago-German (University of California at Davis, USA) Stefano Sciuto (Università di Torino, Italy) Domenico Seminara (Università di Firenze, Italy) Lorenzo Sindoni (Università di Udine, Italy) Kellogg S. Stelle (Imperial College, London, UK) Cosimo Stornaiolo (INFN, Sezione di Napoli, Italy) Ward Struyve (Perimeter Institute, Waterloo, Canada) Makoto Tanabe (Waseda University, Tokyo, Japan) Daniel Terno (Perimeter Institute, Waterloo, Canada) Charles Wang (Lancaster University, UK) Silke Weinfurtner (Victoria University, Wellington, New Zealand) Hans Westman (Perimeter Institute, Waterloo, Canada) Ruth Williams (DAMTP, University of Cambridge, UK) Tetsuyuki Yukawa (Graduate U. for Adv. Studies, Kanagawa, Japan) Jorge Zanelli (CECS, Santiago, Chile)

  4. 3rd International Conference on Turbulent Mixing and Beyond

    Science.gov (United States)

    Abarzhi, Snezhana I.; Gauthier, Serge; Keane, Christopher J.; Niemela, Joseph J.

    2013-07-01

    the accepted contributions have been reviewed by the international team of 27 members of the Scientific Committee, with every contribution considered by four to eleven experts. In the majority of cases, the opinions of referees with diverse backgrounds and expertise converged. In 2011, the award 'Turbulent Mixing and Beyond for Youth' was issued to Gregory P Bewley (Max Plank Institute for Dynamics and Self-Organization, Germany) and Robert Zimmermann (Ecole Normale Superieure de Lyon, France) in recognition of their contributions to TMB-related scientific problems. The Best Poster Award was issued by Physica Scripta to Michael Winkler (University of Potsdam, Germany) in recognition of their poster presentation at TMB-2011. 5. Organization and acknowledgments The Third International Conference on Turbulent Mixing and Beyond was organized by the following members of the Organizing Committee: • Snezhana I Abarzhi (Chairperson, University of Chicago, USA) • Malcolm J Andrews (Los Alamos National Laboratory, USA) • Hiroshi Azechi (Institute for Laser Engineering, Osaka, Japan) • Vladimir E Fortov (Institute for High Energy Density, Russia) • Boris Galperin (Organizer of the Special Course, University of South Florida, USA) • Serge Gauthier (Commissariat à l'Energie Atomique, France) • Christopher J Keane (Lawrence Livermore National Laboratory, USA) • Joseph J Niemela (Local Organizer, International Centre for Theoretical Physics, Italy) • Katepalli R Sreenivasan (New York University, USA) The conference and course were sponsored by several agencies and institutions in the USA, Europe, Russia and Japan. The Organizing Committee of the TMB-2011 gratefully acknowledges support of the: • National Science Foundation (NSF), USA. Programmes: Plasma Physics; Physics Education and Interdisciplinary Research; Astronomy and Astrophysics; Applied Mathematics; Particulate and Multiphase Processes; Combustion, Fire and Plasma Systems • European Office of

  5. PREFACE Turbulent Mixing and Beyond

    Science.gov (United States)

    Abarzhi, Snezhana I.; Gauthier, Serge; Niemela, Joseph J.

    2010-12-01

    confined plasmas, magneto-convection, magneto-rotational instability, dynamo; Canonical plasmas: coupled plasmas, anomalous resistance, ionosphere; Physics of atmosphere: environmental fluid dynamics, weather forecasting, turbulent flows in stratified media and atmosphere, non-Boussinesq convection; Geophysics and Earth science: mantle-lithosphere tectonics, oceanography, turbulent convection under rotation, planetary interiors; Combustion: dynamics of flames and fires, deflagration-to-detonation transition, blast waves and explosions, flows with chemical reactions, flows in jet engines; Mathematical aspects of non-equilibrium dynamics: vortex dynamics, singularities, discontinuities, asymptotic dynamics, weak solutions, well- and ill-posedness, continuous transports out of thermodynamic equilibrium; Stochastic processes and probabilistic description: long-tail distributions and anomalous diffusion, data assimilation and processing methodologies, error estimate and uncertainty quantification, statistically unsteady processes; Advanced numerical simulations: continuous DNS/LES/RANS, molecular dynamics, Monte-Carlo, predictive modeling, validation and verification of numerical models; Experimental diagnostics: model experiments in high energy density and low energy density regimes, plasma diagnostics, fluid flow visualizations and control, opto-fluidics, novel optical methods, holography, advanced technologies. TMB-2009 was organized by the following members of the Organizing Committee: Snezhana I Abarzhi (chairperson, Chicago, USA) Malcolm J Andrews (Los Alamos National Laboratory, USA) Sergei I Anisimov (Landau Institute for Theoretical Physics, Russia) Hiroshi Azechi (Institute of Laser Engineering, Osaka, Japan) Serge Gauthier (Commissariat à l'Energie Atomique, France) Christopher J Keane (Lawrence Livermore National Laboratory, USA) Robert Rosner (Argonne National Laboratory, USA) Katepalli R Sreenivasan (International Centre for Theoretical Physics, Italy) Alexander

  6. Original Inventions based on Chemical scaffolds and electro-physical activity-derived biosimilars interacting with specialties in biology yielding platforms for analysis in virology and antiviral compounds

    Directory of Open Access Journals (Sweden)

    Yamaji N

    2014-11-01

    cater the need to prevent the spreading of contagious viruses during epidemics which may occur in the future. However it is essential to study the specific targets of Clinister in viruses at a molecular level, and the same is under progress. Invention – II : A unique polymer invented by a chemical engineer A chemical engineer Prof. Yuichi Mori jointly with polymer scientist Dr Hiroshi Yoshioka developed a thermoreversible polymer (TGP hydrogel composed of thermoresponsive polymer block [poly (Nisopropylacrylamide- co-n-butyl methacrylate (poly NIPAAm-co-BMA] and the hydrophilic polymer block [polyethylene glycol (PEG] (commercial name :Mebiol gel [5]. This Mebiol gel provides a suitable in vitro environment enabling culture expansion of cells in the lab without the use of biological components such as amniotic membrane or feeder layers. TGP has been earlier employed for the three-dimensional culture of many cell types like corneal limbal stem cells [6], chondrocytes [7], embryonic stem cells [8], hepatocytes [9], induced pluripotent stem (iPS cells [8] and bone marrow mononuclear cells [10]. TGP has been used for transportation of corneal endothelial precursor cells over long distances without cool preservation [11], for micro-encapsulation of islet cells [12] and as a wound dressing [13]. TGP has been intralesionally applied along with stem cells in an animal model of spinal cord in injury [10]. TGP is a unique polymer capable of maintaining stem cells in an undifferentiated manner for a longer period of time [14]. It does not affect the gene expression profile [15] and the karyotype of the cells is maintained even after long term culture [16]. The safety and efficacy of TGP as a valuable scaffold material has been established in the various in vitro and translational studies [5]. Inter-Disciplinary-Interaction based on the Invention-II: Mebiol Gel as a 3D scaffold for hepatocytes and viral replication Mebiol Gel was used as a 3D scaffold for growing hepatocyte cell