Sample records for kan-su nung yeh

  1. Security Analysis of Yeh-Tsai Security Mechanism (United States)

    Yum, Dae Hyun; Shin, Jong Hoon; Lee, Pil Joong

    Yeh and Tsai recently proposed an enhanced mobile commerce security mechanism. They modified the lightweight security mechanism due to Lam, Chung, Gu, and Sun to relieve the burden of mobile clients. However, this article shows that a malicious WAP gateway can successfully obtain the mobile client's PIN by sending a fake public key of a mobile commerce server and exploiting information leakage caused by addition operation. We also present a countermeasure against the proposed attack.

  2. Multinarasi Relief Yeh Pulu Basis Penciptaan Seni Lukis Kontemporer

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    I Wayan Adnyana


    Full Text Available Kajian ini merupakan skema penelitian terapan, yang bertujuan untuk mengungkap konsep multinarasi relief Yeh Pulu, Bedulu, Gianyar, Bali, sebagai basis penciptaan seni lukis kontemporer. Secara metodologis penelitian ini dilakukan dalam dua tahapan: penelitian lapangan (kajian atas narasi relief berdasar perspektif ikonologi Panofsky (1971, dan berikutnya penelitian eksperimen terkait penciptaan seni lukis kontemporer berdasar perspektif ‘art practice as a research’ (Sullivan, 2005 yang menunjuk pada tiga tahapan: eksperimen medium, bahasa visual, dan penyusunan konteks yang relevan. Berdasar kajian ikonologi, terutama tahap analisis ikonografi, ditemukan bahwa narasi relief Yeh Pulu bersifat multinarasi, yakni pahatan relief yang memiliki beragam jenis tema cerita, seperti praktik pertanian, berburu, meditasi, pesta, asmara, dan lain-lain. Kemudian konsep multinarasi dalam penciptaan seni lukis kontemporer, menjadi: (a secara medium menggunakan multiteknik dan medium; (b bahasa visual, menghadirkan berbagai adegan secara berulang, terpadu dan bahkan terkesan saling berlawanan; (c konteks yang relevan, dengan memasukan ikon tokok-toko pahlawan dunia pop, seperti superman, superwomen, dan lain-lain. Secara ikonologis, bangunan visual yang mempertemukan adegan multinarasi relief Yeh Pulu dengan narasi kepahlawanan dunia pop, menjadi semakin menguatkan konsep multinarasi dalam membangun pesan kepahlawanan dunia sehari-hari dalam karya seni lukis kontemporer semakin berhasil. Penelitian ini melibatkan: Anak Agung Rai Remawa (pengumpul data, dan  Ni Luh Desi In Diana Sari (fotografi dan layout. This paper serves as an applied research scheme which aims to reveal the concept of multiple narratives of Yeh Pulu Relief, located in Bedulu, Bali, as the basis for the creation of contemporary painting. Methodologically speaking, this study was conducted in two stages: a field research (a field study on the relief narratives based on Panofsky

  3. Students Learn about Chinese Culture through the Folktale "Yeh-Shen": Emphasizing Figurative Language Interpretation (United States)

    Palmer, Barbara C.; Sun, Lingzhi; Leclere, Judith T.


    This article will analyze the figurative language that reflects Chinese traditional society and culture in "Yeh-Shen." The authors will consider both the figures of speech and the figures of thought (to include symbolism) that provide insight into an understanding of the Chinese culture through a reading of "Yeh-Shen." This analysis can be used by…

  4. YehZYXW of Escherichia coli Is a Low-Affinity, Non-Osmoregulatory Betaine-Specific ABC Transporter. (United States)

    Lang, Shenhui; Cressatti, Marisa; Mendoza, Kris E; Coumoundouros, Chelsea N; Plater, Samantha M; Culham, Doreen E; Kimber, Matthew S; Wood, Janet M


    Transporter-mediated osmolyte accumulation stimulates the growth of Escherichia coli in high-osmolality environments. YehZYXW was predicted to be an osmoregulatory transporter because (1) osmotic and stationary phase induction of yehZYXW is mediated by RpoS, (2) the Yeh proteins are homologous to the components of known osmoregulatory ABC transporters (e.g., ProU of E. coli), and (3) YehZ models based on the structures of periplasmic betaine-binding proteins suggested that YehZ retains key betaine-binding residues. The betaines choline-O-sulfate, glycine betaine, and dimethylsulfoniopropionate bound YehZ and ProX with millimolar and micromolar affinities, respectively, as determined by equilibrium dialysis and isothermal titration calorimetry. The crystal structure of the YehZ apoprotein, determined at 1.5 Å resolution (PDB ID: 4WEP ), confirmed its similarity to other betaine-binding proteins. Small and nonpolar residues in the hinge region of YehZ (e.g., Gly223) pack more closely than the corresponding residues in ProX, stabilizing the apoprotein. Betaines bound YehZ-Gly223Ser an order of magnitude more tightly than YehZ, suggesting that weak substrate binding in YehZ is at least partially due to apo state stabilization. Neither ProX nor YehZ bound proline. Assays based on osmoprotection or proline auxotrophy failed to detect YehZYXW-mediated uptake of proline, betaines, or other osmolytes. However, transport assays revealed low-affinity glycine betaine uptake, mediated by YehZYXW, that was inhibited at high salinity. Thus, YehZYXW is a betaine transporter that shares substrate specificity, but not an osmoregulatory function, with homologues like E. coli ProU. Other work suggests that yehZYXW may be an antivirulence locus whose expression promotes persistent, asymptomatic bacterial infection.


    Directory of Open Access Journals (Sweden)



    Full Text Available ABSTRACT The Bali Sustainable Development Project suggested that the sustainable development concept for Bali should reflect a balance between economy, environment and culture. This should, therefore incorporate the need for continuity of natural resources and production, the need for continuity of culture and the balances within culture, and development as an "optimum process" that can enhance quality of life. The Bali Sustainable Development Project has developed seven special criteria : (1 ecological integrity (2 efficiency (3 equity: (4cultural integrity (5 community (6 to integrate key factors, such as economy, environment, and agriculture and tourism; and (7 to enhance the capabilities of its institutions at all levels to address all needs and improve quality of life. Yeh Gangga Beach, the tourism destination in Tabanan was given a presentation from the Tourism Program of Udayana University about “Tourism Sustainable in Yeh Gangga Beach”. Responses from the people were very enthusiastics and positif because according factual issues in that destination, the people want to participate directly to increase the profit from that tourism activities.

  6. The impact of nonpolar lipids on the regulation of the steryl ester hydrolases Tgl1p and Yeh1p in the yeast Saccharomyces cerevisiae. (United States)

    Klein, Isabella; Korber, Martina; Athenstaedt, Karin; Daum, Günther


    In the yeast Saccharomyces cerevisiae degradation of steryl esters is catalyzed by the steryl ester hydrolases Tgl1p, Yeh1p and Yeh2p. The two steryl ester hydrolases Tgl1p and Yeh1p localize to lipid droplets, a cell compartment storing steryl esters and triacylglycerols. In the present study we investigated regulatory aspects of these two hydrolytic enzymes, namely the gene expression level, protein amount, stability and enzyme activity of Tgl1p and Yeh1p in strains lacking both or only one of the two major nonpolar lipids, steryl esters and triacylglycerols. In a strain lacking both nonpolar lipids and consequently lipid droplets, Tgl1p as well as Yeh1p were present at low amount, became highly unstable compared to wild-type cells, and lost their enzymatic activity. Under these conditions both steryl ester hydrolases were retained in the endoplasmic reticulum. The lack of steryl esters alone was not sufficient to cause an altered intracellular localization of Tgl1p and Yeh1p. Surprisingly, the stability of Tgl1p and Yeh1p was markedly reduced in a strain lacking triacylglycerols, but their capacity to mobilize steryl esters remained unaffected. We also tested a possible cross-regulation of Tgl1p and Yeh1p by analyzing the behavior of each hydrolase in the absence of its counterpart steryl ester hydrolases. In summary, this study demonstrates a strong regulation of the two lipid droplet associated steryl ester hydrolases Tgl1p and Yeh1p due to the presence/absence of their host organelle. Copyright © 2017 Elsevier B.V. All rights reserved.

  7. Karl VI. & Elisabeth Christine: Die böhmische Krönung 1723

    Czech Academy of Sciences Publication Activity Database

    Vácha, Štěpán; Veselá, I.; Vlnas, V.; Vokáčová, P.


    Roč. 21, 1/2 (2010), s. 226-231 ISSN 0940-4007 Institutional research plan: CEZ:AV0Z80330511 Keywords : coronation * emperor Charles VI * empress Elisabeth Christine of Braunschweig-Wolfenbüttel * baroque * festivities Subject RIV: AL - Art, Architecture, Cultural Heritage


    Directory of Open Access Journals (Sweden)



    Full Text Available Livestock is one business that was developed in order to meet basic human needs of the flesh. In its development, livestock will produce waste harmful to the environment. The purpose of this study to determine the characteristics and environmental management of farms, the quality and quantity of waste and its impact on the environment and to know the public perception and labor to the impact of livestock on the environment, economy and social life of communities around the farm and ranch labor. Characteristics and environmental management by the entrepreneur obtained by distributing questionnaires livestock determination of the sample by random sampling, samples for the determination of the quality and quantity of livestock waste with purposive sampling. Samples were taken at three points of different sewage farms and compared with the Minister of State for the Environment No. 11 of 2009 and four points on the body of water and then compared with the Bali gubernatorial No.8 of 2007. Samples were analyzed in situ and laboratory. To know the public perception and labor obtained by distributing questionnaires determination of samples with random sampling. Environmental management by the entrepreneur is less cattle. quality of wastewater from hog farms shows the parameters of TSS (1082.57 mg / 1. quantity of wastewater from pig farms outlet (Qo2 0.004 m3/dt, TSS pollutant load on a pig farm (4330.68 mg / dt. Parameter that exceeds the quality standard on water bodies (TSS, BOD5, COD. Public perception and labor to the impact of farm businesses is positive (good.

  9. Pramana – Journal of Physics | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    -Nung Yang Su-Hsuan Chu Bing-Ling Lu · More Details Abstract Fulltext PDF. Kak's quantum key distribution (QKD) protocol provides not only the distribution but also the integrity of secret key simultaneously in quantum channel.

  10. 專論/From the Viewpoints of People’s Need of Information and Social Activities toDiscuss the Difference between Public Library and Internet/葉乃靜(Nei-Ching Yeh

    Directory of Open Access Journals (Sweden)

    葉乃靜 Nei-Ching Yeh


    Full Text Available This paper aims to discuss the difference and the similarities between the public library and the Internet service, especially focused on web 2.0 websites, and discovered some helpful techniques from the Internet, which could be derived to develop the system used in the public library. This study applied comparative research method to elicit the difference between the public library and Internet service. Based on the following viewpoints, the characteristics of people’s daily life, people’s needs for information and social interaction, and types of resources, this paper elucidated the difference between public libraries and Internet service. This paper suggests that the public library could examine the information defined by the user and know its application in daily life to recognize its method of application in service designs. 本文旨在探討公共圖書館與網路服務的異同,尤其關注web 2.0 網站。基於網路的受歡迎,引發作者試圖由網路服務尋找對公共圖書館服務之啟發動機。本文採用比較研究法的精神,了解公共圖書館與網路服務的差異,再找出可能對提升公共圖書館服務的歡迎度有助益的策略建議。本文進行比較研究的基礎如下:日常生活的特徵、民眾對資訊和社會互動的基礎、公共圖書館與網路提供之資源的類型。文末建議,公共圖書館可以審視讀者認知的資訊,及其如何被應用於日常生活,再由此思考公共圖書館的可行作法。 頁次:4-13

  11. The history of ginseng in the management of erectile dysfunction in ancient China (3500-2600 BCE

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    Rajesh Nair


    Full Text Available Emperor Shen-Nung was the second of China′s mythical emperors (3500-2600 BCE. Widely considered the father of Chinese medicine, he catalogued over 365 species of medicinal plants which he personally tasted. Through his treatise ′Shen Nung Benchau Jing′, we relive Emperor Shen-Nung′s contribution to urology with reference to his management of erectile dysfunction. Time-related sources in medical and historical literature were reviewed, including the ′Shen Nung Benchau Jing′ (The medicine book of Emperor Shen-Nung, archives and manuscripts at the Wellcome History of Medicine Collection, the Royal Society of Medicine, London, The Hong Kong Museum of Medical Sciences, and The Museum of Medical History, Shanghai, China. Chinese traditional herbal medicine began approximately 5000 years ago. Agricultural clan leader, Emperor Shen-Nung, was said to have a ′crystal-like belly′ to watch the reactions in his own stomach of the herbs he collected. Ginseng was among of Shen Nung′s contributions to herbal medicine. He experienced a warm and sexually pleasurable feeling after chewing the root. He advocated this as a treatment for erectile dysfunction and used it to stimulate sexual appetite. The reputation of ginseng as an aphrodisiac is based on the doctrine of signatures, since the adult root has a phallic shape. Shen-Nung believed that ginseng′s resemblance to the human form is proof of its rejuvenative and aphrodisiac properties. It was believed that the closer the similarity to the human figure, the more potent the root. The use of ginseng for erectile dysfunction by Emperor Shen-Nung was unique for its time. It continues to hold parallels as a modern-day herbal aphrodisiac 5000 years on.

  12. Der französische GAV ist unrealistisch

    CERN Multimedia


    "Seit über zwei Wochen ist bei Genf ein Arbeitskonflikt im Gang. Die Arbeiter, die für das CERN eine gigantische Forschungsanlage bauen sollen, verlangen eine bessere Entlönung. Doch das federfürende Baukonsortium will nicht darauf eingehen, und die CERN-Verantwortlichen halten sich aus der Sache raus" (1 page).

  13. AHP 10: Story: A Stolen Journey

    Directory of Open Access Journals (Sweden)

    Blo bzang tshe ring བློ་བཟང་ཚེ་རིང་།


    Full Text Available BIo bzang tshe ring (b 1984 is from A mgon Village, A mchog Town, Bsang chu County, Kan Iho Tibetan Autonomous Prefecture, Kan su'u Province. He says, "I wrote this story based on what I was told by the three men who brought the main character of the story to Zi ling City in their car."

  14. Identification of Human Factors Concerns in Joint Strike Fighter and Training Recommendations (United States)


    thus resulting in attentional capture or tunneling. Yeh, Wickens and Seagull (1999) pointed out that the scanning cost of head-up display clutter...psychophysiological measures. International Journal of Aviation Psychology, 12(1), 3-18. 137 Yeh, M., Wickens, C.D., & Seagull , F.J. (1999, December

  15. Stereoselectivity and substrate specificity in the kinetic resolution of methyl-substituted 1-oxaspiro[2.5]octanes by Rhodotorula glutinis epoxide hydrolase

    NARCIS (Netherlands)

    Weijers, C.A.G.M.; Meeuwse, P.; Herpers, R.L.J.M.; Franssen, M.C.R.; Sudhölter, E.J.R.


    [GRAPHICS] The kinetic resolution of a range of methyl-substituted 1-oxaspiro[2.5]octanes by yeast epoxide hydrolase (YEH) from Rhodotorula glutinis has been investigated. The structural determinants of substrate specificity and stereoselectivity of YEH toward these substrates appeared to be the

  16. Virtual reality simulation for the optimization of endovascular procedures: current perspectives


    Rudarakanchana, Nung; Van Herzeele, Isabelle; Desender, Liesbeth; Cheshire, Nicholas JW


    Nung Rudarakanchana,1 Isabelle Van Herzeele,2 Liesbeth Desender,2 Nicholas JW Cheshire1 1Department of Surgery, Imperial College London, London, UK; 2Department of Thoracic and Vascular Surgery, Ghent University Hospital, Ghent, BelgiumOn behalf of EVEREST (European Virtual reality Endovascular RESearch Team)Abstract: Endovascular technologies are rapidly evolving, often requiring coordination and cooperation between clinicians and technicians from diverse specialties. These multidisciplinary...

  17. Electronic flight bag (EFB) : 2010 industry survey (United States)


    This document provides an overview of Electronic Flight Bag (EFB) systems and capabilities, as of June 2010. This document updates and replaces the April 2007 EFB Industry Review (Yeh and Chandra, 2007). As with the previous industry survey, the focu...

  18. Molecular genetics of schizophrenia: past, present and future

    Indian Academy of Sciences (India)


    leucocyte antigen; IDDM, insulin dependent diabetes mellitus; MAO, monoamine oxidase; MHC, ... In this review, we summarize the evolution of schizophrenia genetics from ...... K, Yeh J I and Hsiao K J 1999 Systematic mutation analysis.

  19. loci for phylogenetic inference and authentication among ...

    African Journals Online (AJOL)


    Apr 1, 2015 ... 2Department of BioIndustry Technology, Da-Yeh University, Changhua 51591, Taiwan. 3Department of Bioresources ... lignum and leaves (Huang, 1984; Ou 1989; Chang, 1995). ... Mo-tuo-wan Mountain (Hualien County).

  20. Analysis of genetic diversity and estimation of inbreeding coefficient ...

    African Journals Online (AJOL)



    Jan 18, 2010 ... Key words: Genetic diversity, microsatellite markers, Caspian horse breed. INTRODUCTION ... heterozygosity, observed and effective number of alleles at each ... computer program version 1.31 (Yeh et al., 1999). Based on ...

  1. Sine Fine: Dios, los Habsburgo y el traspaso de las insignias de poder en el Quinientos


    Mínguez, Víctor


    Partiendo del estudio de una pintura flamenca de Ambrosius Francken, Allegorie auf die Kaiserkrönung Ferdinands II. am 9. September 1619 (Deutsches Historisches Museum de Berlín), se analiza en esta investigación la construcción iconográfica de la entrega divina de las insignias del poder a los emperadores o reyes de la Casa de Habsburgo, a través de diversos grabados y pinturas. Estas imágenes configuran un discurso visual y retórico que pretendía justificar públicamente la...

  2. Cinderella's Lessons on Footbinding: How Tiny Feet Found their Way into the Chinese Cinderella Story

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    Tyler Scott Smith


    Full Text Available The story of Cinderella has had many variants, some dating back to ancient Tibetan trade routes and dynastic China. When the tale is analysed in comparison to other variants it is found that in the Chinese version Yeh-Shen (Cinderella is prized for the small size of her feet. The result of Yeh-Shen having small feet in the story is that she is led her into wealth, power and marriage, the same pursuable goals that led to the custom of footbinding. In southern China the custom of footbinding became a historically defining feature of the society. A women's beauty and her delicacy were judged by the size of her feet, and small feet were the aim of the binding. Small feet played such an important role in the society that it can be found as early as the ninth century C.E., in the traditional oral story, Yeh-Shen.

  3. An Improvement on Remote User Authentication Schemes Using Smart Cards

    Directory of Open Access Journals (Sweden)

    Chin-Ling Chen


    Full Text Available In 2010, Yeh et al. proposed two robust remote user authentication schemes using smart cards; their claims were such that their schemes defended against ID-theft attacks, reply attacks, undetectable on-line password guessing attacks, off-line password guessing attacks, user impersonation attack, server counterfeit attack and man-in-the-middle attack. In this paper, we show that Yeh et al.’s schemes are still vulnerable to ID-theft attack, off-line password guessing attacks, undetectable on-line password guessing attacks and user impersonation attack. Notably, problems remain in situations where the user lost a smart card or the malicious legal user. To remedy these flaws, this paper proposes an improvement on Yeh et al.’s remote user authentication schemes using smart cards.

  4. Cinderella's Lessons on Footbinding: How Tiny Feet Found their Way into the Chinese Cinderella Story


    Tyler Scott Smith


    The story of Cinderella has had many variants, some dating back to ancient Tibetan trade routes and dynastic China. When the tale is analysed in comparison to other variants it is found that in the Chinese version Yeh-Shen (Cinderella) is prized for the small size of her feet. The result of Yeh-Shen having small feet in the story is that she is led her into wealth, power and marriage, the same pursuable goals that led to the custom of footbinding. In southern China the custom of footbinding b...

  5. Conserved ABC Transport System Regulated by the General Stress Response Pathways of Alpha- and Gammaproteobacteria

    Energy Technology Data Exchange (ETDEWEB)

    Herrou, Julien; Willett, Jonathan W.; Czy; #380; , Daniel M.; Babnigg, Gyorgy; Kim, Youngchang; Crosson, Sean (UC)



    Brucella abortusσE1is an EcfG family sigma factor that regulates the transcription of dozens of genes in response to diverse stress conditions and is required for maintenance of chronic infection in a mouse model. A putative ATP-binding cassette transporter operon,bab1_0223-bab1_0226, is among the most highly activated gene sets in the σE1regulon. The proteins encoded by the operon resemble quaternary ammonium-compatible solute importers but are most similar in sequence to the broadly conserved YehZYXW system, which remains largely uncharacterized. Transcription ofyehZYXWis activated by the general stress sigma factor σSinEnterobacteriaceae, which suggests a functional role for this transport system in bacterial stress response across the classesAlphaproteobacteriaandGammaproteobacteria. We present evidence thatB. abortusYehZYXW does not function as an importer of known compatible solutes under physiological conditions and does not contribute to the virulence defect of a σE1-null strain. The solein vitrophenotype associated with genetic disruption of this putative transport system is reduced growth in the presence of high Li+ion concentrations. A crystal structure ofB. abortusYehZ revealed a class II periplasmic binding protein fold with significant structural homology toArchaeoglobus fulgidusProX, which binds glycine betaine. However, the structure

  6. Allozyme variation in Picea mariana from Newfoundland: Discussion (United States)

    William B. Critchfield


    In their recent paper describing the distribution of genetic variation in black spruce (Picea mariana (Mill.) B.S.P.) on the island of Newfoundland, Yeh et el. (1986) concluded that a center of variability in west-central Newfoundland derived from ancestral populations that persisted on the island during the last (Wisconsin) glaciation. They...

  7. Author Details - AJOL

    African Journals Online (AJOL)

    Yeh-Gorocica, A. Vol 6, No 1 (2016) - Articles First molecular evidence of Toxoplasma gondii in opossums (Didelphis virginiana) from Yucatan, Mexico Abstract PDF. ISSN: 2218-6050. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's ...

  8. A generalized solution for groundwater head fluctuation in a tidal ...

    Indian Academy of Sciences (India)

    Mo-Hsiung Chuang1 and Hund-Der Yeh2,∗. 1Department of Urban Planning and Disaster Management, Ming-Chuan University,. Gweishan District, Taoyuan, Taiwan. 2Institute of Environmental Engineering, National Chiao Tung University, Hsinchu, Taiwan. ∗. Corresponding author. e-mail:

  9. Exploitation, exploration, and how learning affects strategic intent in multinational enterprises' foreign direct investment decisions: A commentary essay

    NARCIS (Netherlands)

    Kamal, F.; Englis-Danskin, Paula


    Research on foreign direct investment is a rich vein of inquiry in international business and management literature. Scholars explore various aspects of FDI including the reasons for location selection. Chen and Yeh's research is in that tradition. Under the title of “Re-examining location

  10. Zhou et al., Afr J Tradit Complement Altern Med. (2015) 12(4):87-95 ...

    African Journals Online (AJOL)


    containing 10 rats: (1) I/R-ethanol group (IRI), in which the rats were .... Wy14643 Pretreatment Alleviated Liver Pathological Changes in Liver I/R Injury .... IRI in myocardial and cerebral by suppressing inflammation(Yeh CH,2006; Collino M,.

  11. photoautotrophic, photomixotrophic

    African Journals Online (AJOL)

    Dion Daniels

    on the adaptation of papaya plants, strengthening the function of the stomata and with this, allowing .... culture vessels with a total volume of 250 mL with 30 mL of liquid ..... scaling. Physiological parameters: Chlorophyll a, b and carotenoids. In terms ..... Soluble sugars mediate .... Yu TA, Yeh SD, Cheng YH, Yang JS (2000).

  12. Mental Health Help-Seeking Behaviors among Asian American Community College Students: The Effect of Stigma, Cultural Barriers, and Acculturation (United States)

    Han, Meekyung; Pong, Helen


    According to the 2008 U.S. Census, there are 15.5 million Asian Americans in the United States, and 17% are students enrolled in a university (Shea & Yeh, 2008). Asian American college students in higher education are oftentimes perceived as the "model minority" with high academic achievements and few mental and/or behavioral…

  13. A unifying framework for the problem of adjudicating conflicting claims

    DEFF Research Database (Denmark)

    Hougaard, Jens Leth; Østerdal, Lars Peter Raahave; Moreno-Terero, Juan D.


    operators in order to uncover the structure of such a space. In this paper, we generalize their analysis upon presenting and studying a general family of operators inspired by three apparently unrelated approaches to the problem of adjudicating conflicting claims. We study the structural properties......In a recent paper, Thomson and Yeh [Thomson, W., Yeh, C.-H., 2008. Operators for the adjudication of conflicting claims. Journal of Economic Theory 143, 177–198] introduced the concept of operators on the space of rules for the problem of adjudicating conflicting claims. They focused on three...... of this family and show, in particular, that most of Thomson and Yeh’s results are specific cases of our study....

  14. High Entropy Alloys: A Current Evaluation of Founding Ideas and Core Effects and Exploring Nonlinear Alloys (Postprint) (United States)


    299 (2004). 9. S. Ranganathan , Curr. Sci. 85, 1404 (2003). 10. F. Otto, Y. Yang, H. Bei, and E.P. George, Acta Mater. 61, 2628 (2013). 11. O.N...W. Yeh, and S. Ranganathan , High-Entropy Alloys (Oxford: Butterworth-Heinemann, 2014). 33. Y. Zou, S. Maiti, W. Steurer, and R. Spolenak, Acta Mater...Intermetallics 41, 96 (2013). 36. X. Yang and Y. Zhang, Mater. Chem. Phys. 132, 233 (2012). 37. S. Ranganathan , Personal communication (Bangalore: In

  15. Microstructure of Amorphous and Semi-Crystalline Polymers. (United States)


    in IFigure 1. Again. nf evidence ofan ii( hilar featir’s is seen and the comnbinaion of the bright-field and dark-field micrographs provides strfng...S. Y’. Yeh. (’re v1c". Aacrm ,l.m I 1rcm. I, 17311972). 5. S. Krinim and A. V. Tabo sky. Textile Res. J. 21, 805 (1951). 6. A. Bij rnhatig

  16. Controllable Tamm states in magnetophotonic crystal

    Energy Technology Data Exchange (ETDEWEB)

    Merzlikin, A.M. [Institute for Theoretical and Applied Electromagnetics, Russian Academy of Science, 13/19 Izhorskaya ul., 125412 Moscow (Russian Federation); Vinogradov, A.P. [Institute for Theoretical and Applied Electromagnetics, Russian Academy of Science, 13/19 Izhorskaya ul., 125412 Moscow (Russian Federation)]. E-mail:; Dorofeenko, A.V. [Institute for Theoretical and Applied Electromagnetics, Russian Academy of Science, 13/19 Izhorskaya ul., 125412 Moscow (Russian Federation); Inoue, M. [Department of Electrical and Electronic Engineering, Toyohashi University of Technology, 1-1 Hibari-Ga-Oka, Tempaku, Toyohashi 441-8580 (Japan); Levy, M. [Department of Physics, Michigan Technological University, 1400 Townsend Drive Houghton, MI 49931-1295 (United States); Granovsky, A.B. [Faculty of Physics, M.V. Lomonosov Moscow State University, Vorob' evy Gory, 119992 Moscow (Russian Federation)


    We study the Tamm states existing at the interface of a 1D magnetophotonic crystal made of magneto-optic material and a material with natural anisotropy. It is shown that in such a photonic crystal (PC) Yeh's band gap may exist, which causes a special type of the Tamm state. As this state is due to magneto-optic properties, it is controllable by an external magnetic field.

  17. Controllable Tamm states in magnetophotonic crystal

    International Nuclear Information System (INIS)

    Merzlikin, A.M.; Vinogradov, A.P.; Dorofeenko, A.V.; Inoue, M.; Levy, M.; Granovsky, A.B.


    We study the Tamm states existing at the interface of a 1D magnetophotonic crystal made of magneto-optic material and a material with natural anisotropy. It is shown that in such a photonic crystal (PC) Yeh's band gap may exist, which causes a special type of the Tamm state. As this state is due to magneto-optic properties, it is controllable by an external magnetic field

  18. A randomized, double-blind, placebo-controlled study of oral antioxidant supplement therapy in patients with dry eye syndrome


    Huang, Jehn-Yu; Yeh, Po-Ting; Hou, Yu-Chih


    Jehn-Yu Huang, Po-Ting Yeh, Yu-Chih Hou Department of Ophthalmology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan Purpose: To evaluate the efficacy of oral antioxidant supplementation in the treatment of patients with dry eye syndrome (DES). Methods: A prospective, randomized, double-blinded study compared the effects of an antioxidant supplement (containing anthocyanosides, astaxanthin, vitamins A, C, and E, and several herbal extract...

  19. The use of Optical Magnetic Twisting Cytometry and Flourescence Resonance Energy Transfer to quantify force-induced protein dissociation in the nucleus of a living cell




    Authors: Yeh-Chuin Poh & Ning Wang ### Abstract Mechanical forces are known to play a significant role in biological processes. These forces can be transmitted to the cell through the cytoskeletal filament network, inducing different biochemical responses within the cytoplasm. Although there have been ample reports showing that cytoplasmic enzymes can be directly activated by a local stress on the cell surface via integrins, there has been no evidence that mechanical forces can direct...

  20. Supporting Battlefield Situation Assessment Through Attention Guidance and Diagnostic Aiding: A Cost-Benefit and Depth of Processing Analysis (United States)


    conceptual framework proposed by Craik and Lockhart (1972) offers a useful approach for examining depth of processing in an information integration task... processing ( Craik & Lockhart , 1972) for a particular unit (i.e., whether cueing decreased target sensitivity) (Yeh & Wickens, 2001). It was also predicted...F.I.M. & Lockhart , R.S. (1972). Levels of processing : A framework for memory research. Journal of Verbal Learning and Verbal Behavior, 11, 671-684

  1. Supporting Situation Assessment through Attention Guidance: A Cost-Benefit and Depth of Processing Analysis (United States)


    Factors, 30(1), 15-24. Craik , F.I.M. & Lockhart , R.S. (1972). Levels of processing : A framework for memory research. Journal of Verbal Learning and... processing ( Craik & Lockhart , 1972) for a particular unit (i.e., whether cueing would increase or decrease the memory for separate attributes of the cued...without processing these cues at a deeper level . Yeh and Wickens (2001, in press) found a similar response bias (beta) in observers who believed the

  2. Internet Journal of Medical Update - EJOURNAL - Vol 3, No 2 (2008)

    African Journals Online (AJOL)

    Lateralization pattern in patients with Schizophrenia and Depression. B Bhushan, A Prakash, R Gupta. · Gender Determination using Fingertip Features. J-F Wang, C-L Lin, Y-H Chang, ML Nagurka, C-W Yen, C Yeh. · Effects of smoking on ...

  3. The Effect of the Ionosphere on Radiowave Signals and Systems Performance Based on Ionospheric Effects Symposium Held on 1-3 May 1990 (United States)


    extensive computer modeling studies were carried out, as summarized in reports and reviews by Croft, 1972; Testud , 1973; Hines, 1974; Yeh and Liu, 1974...1968) and Testud (1972), as a result of some complicated chemistry changes described by Hooke (1968). if the object of the investigation is to...B)l Testud (1972) showed that in addition to the electron density fluctuation, there are other effects complicating the AGW/TID coupling mechanism His

  4. Evaluation of the pressure difference across the core during PWR-LOCA reflood phase

    International Nuclear Information System (INIS)

    Iguchi, Tadashi; Murao, Yoshio


    The flooding rate of the core influences largely cooling of the core during the reflood phase of a PWR-LOCA. Since the void fraction of two-phase flow in the core is important determining the flooding rate, it is essential to examine this void fraction. The void fraction in the core during the reflood phase obtained by experiment was compared with those predicted by the correlations respectively of Akagawa, Nicklin, Zuber, Yeh, Griffice, Behringer and Jhonson. Only Yeh's correlation was found to be usable for the purpose. The pressure difference of the core during the reflood phase was calculated by reflood analyzing code REFLA-1D using Yeh's correlation. Following are the results: (1) During the steady-state period after quenching of the heaters, the prediction agrees within +-15% with the experiment. (2) During the transient period when the quench front is advancing, the prediction is not in agreement with the experiment, the difference being about +-40%. Influence of the advancing quench front upon the void fraction in the core must further be studied. (author)

  5. Security Enhanced User Authentication Protocol for Wireless Sensor Networks Using Elliptic Curves Cryptography

    Directory of Open Access Journals (Sweden)

    Younsung Choi


    Full Text Available Wireless sensor networks (WSNs consist of sensors, gateways and users. Sensors are widely distributed to monitor various conditions, such as temperature, sound, speed and pressure but they have limited computational ability and energy. To reduce the resource use of sensors and enhance the security of WSNs, various user authentication protocols have been proposed. In 2011, Yeh et al. first proposed a user authentication protocol based on elliptic curve cryptography (ECC for WSNs. However, it turned out that Yeh et al.’s protocol does not provide mutual authentication, perfect forward secrecy, and key agreement between the user and sensor. Later in 2013, Shi et al. proposed a new user authentication protocol that improves both security and efficiency of Yeh et al.’s protocol. However, Shi et al.’s improvement introduces other security weaknesses. In this paper, we show that Shi et al.’s improved protocol is vulnerable to session key attack, stolen smart card attack, and sensor energy exhausting attack. In addition, we propose a new, security-enhanced user authentication protocol using ECC for WSNs.

  6. Security enhanced user authentication protocol for wireless sensor networks using elliptic curves cryptography. (United States)

    Choi, Younsung; Lee, Donghoon; Kim, Jiye; Jung, Jaewook; Nam, Junghyun; Won, Dongho


    Wireless sensor networks (WSNs) consist of sensors, gateways and users. Sensors are widely distributed to monitor various conditions, such as temperature, sound, speed and pressure but they have limited computational ability and energy. To reduce the resource use of sensors and enhance the security of WSNs, various user authentication protocols have been proposed. In 2011, Yeh et al. first proposed a user authentication protocol based on elliptic curve cryptography (ECC) for WSNs. However, it turned out that Yeh et al.'s protocol does not provide mutual authentication, perfect forward secrecy, and key agreement between the user and sensor. Later in 2013, Shi et al. proposed a new user authentication protocol that improves both security and efficiency of Yeh et al.'s protocol. However, Shi et al.'s improvement introduces other security weaknesses. In this paper, we show that Shi et al.'s improved protocol is vulnerable to session key attack, stolen smart card attack, and sensor energy exhausting attack. In addition, we propose a new, security-enhanced user authentication protocol using ECC for WSNs.

  7. Virtual reality simulation for the optimization of endovascular procedures: current perspectives

    Directory of Open Access Journals (Sweden)

    Rudarakanchana N


    Full Text Available Nung Rudarakanchana,1 Isabelle Van Herzeele,2 Liesbeth Desender,2 Nicholas JW Cheshire1 1Department of Surgery, Imperial College London, London, UK; 2Department of Thoracic and Vascular Surgery, Ghent University Hospital, Ghent, BelgiumOn behalf of EVEREST (European Virtual reality Endovascular RESearch TeamAbstract: Endovascular technologies are rapidly evolving, often requiring coordination and cooperation between clinicians and technicians from diverse specialties. These multidisciplinary interactions lead to challenges that are reflected in the high rate of errors occurring during endovascular procedures. Endovascular virtual reality (VR simulation has evolved from simple benchtop devices to full physic simulators with advanced haptics and dynamic imaging and physiological controls. The latest developments in this field include the use of fully immersive simulated hybrid angiosuites to train whole endovascular teams in crisis resource management and novel technologies that enable practitioners to build VR simulations based on patient-specific anatomy. As our understanding of the skills, both technical and nontechnical, required for optimal endovascular performance improves, the requisite tools for objective assessment of these skills are being developed and will further enable the use of VR simulation in the training and assessment of endovascular interventionalists and their entire teams. Simulation training that allows deliberate practice without danger to patients may be key to bridging the gap between new endovascular technology and improved patient outcomes.Keywords: virtual reality, simulation, endovascular, aneurysm

  8. Morphological Variation in the Imperfect of hewâ in Onqelos and Jonathan

    Directory of Open Access Journals (Sweden)

    Jerome A. Lund


    Full Text Available Two morphological types of the imperfect of the verb hewâ appear in Onqelos and Jonathan, namely yihwê and yehê. While the two types distinguish gender in the plural, they do not do so in the singular. Statistically, the waw type is marginal in the second and third persons singular, but well attested in the first person singular. The use of the waw type in the singular appears to be conditioned by stylistic considerations, being employed to give the impression of solemnity. It is suggested that the waw type reflects the language of the proto-targum from which it was retained.

  9. Handbook of fiber optics theory and applications

    CERN Document Server

    Yeh, Chai


    Dr. Yeh supplies a firm theoretical foundation in such topics as propagation of light through fibers, fiber fabrication, loss mechanisms, and dispersion properties. He then expands from this into such practical areas as fiber splicing, measuring loss in fibers, fiber-based communications networks, remote fiber sensors, and integrated optics. Whether involved in fiber optics research, design, or practical implementation of systems, this handbook will be extremely useful.Key Features* Here is a comprehensive, ""one-stop"" reference with state-of-the-art information on fiber optics Included is da

  10. Accelerated Exploration of Multi-principal Element Alloys for Structural Applications (Postprint) (United States)


    S. Ranganathan, High Entropy Alloys, Butterworth-Hei- nemann, London, UK, 2014. [6] B. Cantor , I.T.H. Chang, P. Knight, A.J.B. Vincent, Mater. Sci...Kristallogr.-Cryst. Mater. 230 (2015) 55–68. [14] B. Cantor , Entropy 16 (2014) 4749–4768. [15] O.N. Senkov, C. Woodward, D.B. Miracle, JOM. 66 (2014...2014) 1973–1983. [21] F. Otto, Y. Yang, H. Bei, E.P. George , Acta Mater. 61 (2013) 2628–2638. [22] K.Y. Tsai, M.H. Tsai, J.W. Yeh, Acta Mater. 61

  11. A Unifying Framework for the Problem of Adjudicating Conflicting Claims

    DEFF Research Database (Denmark)

    Hougaard, Jens Leth; Moreno-Ternero, Juan D.; Østerdal, Lars Peter Raahave

    the structure of such a space. In this paper, we generalize their analysis upon presenting and studying a general family of operators inspired by three apparently unrelated approaches to the problem of adjudicating conflicting claims. We study the structural properties of this family and show, in particular......In a recent paper, Thomson and Yeh [Operators for the adjudication of conflicting claims, Journal of Economic Theory 143 (2008) 177-198] introduced the concept of operators on the space of rules for the problem of adjudicating conflicting claims. They focussed on three operators in order to uncover...

  12. Combined Effects of Primary and Tertiary Blast on Rat Brain: Characterization of a Model of Blast-induced Mild Traumatic Brain Injury (United States)


    injury in U.S. military personnel. N Engl J Med 364, 2091–2100 (2011) 27. Lu J, Ng KC , Ling GS, Wu J, Poon JF, Kan EM, Tan MH, Wu YJ, Li P...Moochhala S, Yap E, Lee LK, Teo AL, Yeh IB, Ser- gio DM, Chua F, Kumar SD, Ling EA: Effect of blast exposure on the brain structure and cognition in the...12689448] 32. Henderson D, Bielefeld EC, Harris KC , Hu BH. The role of oxidative stress in noise-induced hearing loss. Ear Hear. 2006;27(1):1–19. [PMID

  13. The Mesosphere and Thermosphere, (United States)


    and Joule heating (Q = J.E) and has been studied by many authors (see e.g. [40] and references therein). Testud [41] found that the efficiency of...K/day, respectively. Testud and Vasseur [611 observed a T.I.D. following a magnetic storm and noted that the ion temperature at the 300 km level rose... Testud [62] and Yeh [30] have estimated that heating rates of the order of 10 - 0 watts/m 3 (10 - 9 ergs/cm 3 sec) occur at F-region heights due

  14. Formation and mobilization of neutral lipids in the yeast Saccharomyces cerevisiae. (United States)

    Wagner, A; Daum, G


    Since energy storage is a basic metabolic process, the synthesis of neutral lipids occurs in all kingdoms of life. The yeast Saccharomyces cerevisiae, widely accepted as a model eukaryotic cell, contains two classes of neutral lipids, namely STEs (steryl esters) and TAGs (triacylglycerols). TAGs are synthesized through two pathways governed by the acyl-CoA diacylglycerol acyltransferase Dga1p and the phospholipid diacylglycerol acyltransferase Lro1p. STEs are formed by two STE synthases Are1p and Are2p, two enzymes with overlapping function, which also catalyse TAG formation, although to a minor extent. Neutral lipids are stored in the so-called lipid particles and can be utilized for membrane formation under conditions of lipid depletion. For this purpose, storage lipids have to be mobilized by TAG lipases and STE hydrolases. A TAG lipase named Tgl3p was identified as a major yeast TAG hydrolytic enzyme in lipid particles. Recently, a new family of hydrolases was detected which is required for STE mobilization in S. cerevisiae. These enzymes, named Yeh1p, Yeh2p and Tgl1p, are paralogues of the mammalian acid lipase family. The role of these proteins in biosynthesis and mobilization of TAG and STE, and the regulation of these processes will be discussed in this minireview.

  15. Comparisons of Particle Tracking Techniques and Galerkin Finite Element Methods in Flow Simulations on Watershed Scales (United States)

    Shih, D.; Yeh, G.


    This paper applies two numerical approximations, the particle tracking technique and Galerkin finite element method, to solve the diffusive wave equation in both one-dimensional and two-dimensional flow simulations. The finite element method is one of most commonly approaches in numerical problems. It can obtain accurate solutions, but calculation times may be rather extensive. The particle tracking technique, using either single-velocity or average-velocity tracks to efficiently perform advective transport, could use larger time-step sizes than the finite element method to significantly save computational time. Comparisons of the alternative approximations are examined in this poster. We adapt the model WASH123D to examine the work. WASH123D is an integrated multimedia, multi-processes, physics-based computational model suitable for various spatial-temporal scales, was first developed by Yeh et al., at 1998. The model has evolved in design capability and flexibility, and has been used for model calibrations and validations over the course of many years. In order to deliver a locally hydrological model in Taiwan, the Taiwan Typhoon and Flood Research Institute (TTFRI) is working with Prof. Yeh to develop next version of WASH123D. So, the work of our preliminary cooperationx is also sketched in this poster.

  16. Mobilization of steryl esters from lipid particles of the yeast Saccharomyces cerevisiae. (United States)

    Wagner, Andrea; Grillitsch, Karlheinz; Leitner, Erich; Daum, Günther


    In the yeast as in other eukaryotes, formation and hydrolysis of steryl esters (SE) are processes linked to lipid storage. In Saccharomyces cerevisiae, the three SE hydrolases Tgl1p, Yeh1p and Yeh2p contribute to SE mobilization from their site of storage, the lipid particles/droplets. Here, we provide evidence for enzymatic and cellular properties of these three hydrolytic enzymes. Using the respective single, double and triple deletion mutants and strains overexpressing the three enzymes, we demonstrate that each SE hydrolase exhibits certain substrate specificity. Interestingly, disturbance in SE mobilization also affects sterol biosynthesis in a type of feedback regulation. Sterol intermediates stored in SE and set free by SE hydrolases are recycled to the sterol biosynthetic pathway and converted to the final product, ergosterol. This recycling implies that the vast majority of sterol precursors are transported from lipid particles to the endoplasmic reticulum, where sterol biosynthesis is completed. Ergosterol formed through this route is then supplied to its subcellular destinations, especially the plasma membrane. Only a minor amount of sterol precursors are randomly distributed within the cell after cleavage from SE. Conclusively, SE storage and mobilization although being dispensable for yeast viability contribute markedly to sterol homeostasis and distribution.

  17. Comparative analysis of LytS/LytTR-type histidine kinase/response regulator systems in γ-proteobacteria.

    Directory of Open Access Journals (Sweden)

    Stefan Behr

    Full Text Available Bacterial histidine kinase/response regulator systems operate at the interface between environmental cues and physiological states. Escherichia coli contains two LytS/LytTR-type histidine kinase/response regulator systems, BtsS/BtsR (formerly YehU/YehT and YpdA/YpdB, which have been identified as pyruvate-responsive two-component systems. Since they exhibit remarkable similarity, we analyzed their phylogenetic distribution within the γ-proteobacteria, and experimentally characterized them in a set of representative species. We found that BtsS/BtsR is the predominant LytS/LytTR-type two-component system among γ-proteobacteria, whereas YpdA/YpdB primarily appears in a supplementary role. Based on our observations in E. coli, we used the highly conserved DNA-binding motifs to test the in vivo functionality of both systems in various genera, including Salmonella, Enterobacter, Citrobacter, Xenorhabdus, Yersinia, Aeromonas and Vibrio. The results suggest that, in all cases tested, BtsS/BtsR and YpdA/YpdB respond to different levels of pyruvate in the environment.

  18. Root layering in a tropical forest after logging (Central Vietnam

    Directory of Open Access Journals (Sweden)

    Zdeněk Čermák


    Full Text Available Indigenous stands of tropical rain forests in the region of Kon Ha Nung are one of the most preserved forests in the whole Vietnam. Despite the logging activities mainly in the 1970’s, it was possible to preserve intact forests free from any primary harvesting. In the past, other stands were influenced by the logging to various extent. Some of those stands are managed presently; others were left to natural development. This paper deals with the influence of harvesting activities on the root system in forest stands. In primary stands and in stands with known harvest intensity, samples of root systems were collected. The total weight of dry basis and mainly their layering within the soil profile were assessed. The collected roots were divided into three classes: class I – ≤ 1.0 mm, class II 1.1–5.0 mm, class III – over 5.0 mm in the diameter. In the monitored plots, the total weight of dry basis of fine roots to 1.0 mm ranged from 2.34–3.24 t∙ha−1. The weight of dry basis of roots from 1.0–5.0 mm ranged from 6.57–9.69 t∙ha−1. The majority of roots of class I is presented in the top 10.0 cm of the soil and their share drops with the increasing depth. The roots of class II are distributed more equally. It was impossible to prove the influence of the logging on the root system.


    Directory of Open Access Journals (Sweden)

    Alfredo Jácome Roca


    Full Text Available Los estupefacientes han estado presentes en la historia de la medicina desde la antigüedad. La materia médica china (Pen-ts’ao-Ching atribuida al emperador rojo Shen-nung, incluye a la Cannabis indica para reducir el dolor del reumatismo y por sus beneficios en desórdenes digestivos. El láudano (tintura alcohólica de opio, la esponja anestésica (mandrágora con opio, o la teriaca (polifármaco que contenía opio fueron pilar de la lucha contra el dolor y otros males. El opio proviene del jugo de la corteza verde de la adormidera –variedad de amapola- o Papaver somniferum y ha sido reemplazado como potente analgésico de acción central por su alcaloide morfina o por análogos como la meperidina (1. Desde sus orígenes, el ser humano ha buscado alivio en diversas plantas medicinales, la analgesia, la sedación pero también la euforia. El efecto pasajero y la taquifilaxia generada por el uso continuo impulsan un aumento en la frecuencia y en la cantidad de las dosis, perdiéndose sus beneficios y aumentando su toxicidad. En estos casos, disminuye el número y la sensibilidad de los diferentes receptores, fenómeno conocido como down-regulation. Al ser adictivos, el manejo de estos narcóticos debe ser estrictamente médico y fuertemente regulado, cosa de la que se han librado el alcohol y el tabaco. La prohibición del licor solo llevó al enriquecimiento de los contrabandistas. Hay alucinógenos menos villanos como los obtenidos de la Cannabis sativa, aunque no son demasiado benignos.


    Institute of Scientific and Technical Information of China (English)


    @@Natural Toxins   S01 Susceptibility of Edible Bihalves to Paralytic Shellfish Poisons and Their Donor   Ya-Hui Li* , Deng-Fwu Hwang, Jou-Fang Deng, Taibei, China      S02 Food Safety of Grass Carp Bile Juice   Deng-Fwu Hwang* , Yen-Hung Yeh, Jou-Feng Deng, Taibei, China      S03 Differentiation of Muscular Proteins from Toxic and Non Toxic Puffers   Tai-Yuan Chen* , Deng-Fwu Hwang, Taibei, China      S04 Radiation Resistance of Paralytic Shellfish Poison (PSP) Toxins   Terestia P Acevedo, Philippines

  1. Future foam: Nontrivial topology from bubble collisions in eternal inflation

    International Nuclear Information System (INIS)

    Bousso, Raphael; Freivogel, Ben; Yang, I-S.; Sekino, Yasuhiro; Shenker, Stephen; Susskind, Leonard; Yeh, C.-P.


    We study pocket universes which have zero cosmological constant and nontrivial boundary topology. These arise from bubble collisions in eternal inflation. Using a simplified dust model of collisions we find that boundaries of any genus can occur. Using a radiation shell model we perform analytic studies in the thin-wall limit to show the existence of geometries with a single toroidal boundary. We give plausibility arguments that higher genus boundaries can also occur. In geometries with one boundary of any genus a timelike observer can see the entire boundary. Geometries with multiple disconnected boundaries can also occur. In the spherical case with two boundaries the boundaries are separated by a horizon. Our results suggest that the holographic dual description for eternal inflation, proposed by Freivogel, Sekino, Susskind and Yeh, should include summation over the genus of the base space of the dual conformal field theory. We point out peculiarities of this genus expansion compared to the string perturbation series.

  2. Solving potential field problems in composite media with complicated geometries

    International Nuclear Information System (INIS)

    Yeh, H.


    Recently, Yeh developed a method of solving potential field problems for complicated geometries and theorems of piecewise continuous eigenfunctions which can be used to solve boundary-value problems in composite media by the separation of variables. This paper shows that by a proper arrangement of matching conditions and boundary conditions, this method and these theorems can be applied simultaneously so that the problems in composite media with complicated geometries can be solved. To illustrate this, a heat-conduction problem in a composite cylinder with an abrupt change in cross-section area is solved. Also presented in this paper are the method of handling the nonhomogeneous boundary conditions for composite media and the extension of one of the above-mentioned theorems to include imperfect contact on material boundaries

  3. Comments on Ge Zhaoguang’s Reading of the "Yŏnhaeng-nok" (Journeys to Beijing

    Directory of Open Access Journals (Sweden)

    Wen-hsin Yeh


    Full Text Available Ge Zhaoguang 葛兆光. Xiangxiang yiyu: Du Lichao Chaoxian hanwen Yanxing wenxian zhaji 葛兆光,想象异域:读李朝朝鲜韩文燕行文献札记 [Imagining a foreign place: Notes on Korean Yi-dynasty Beijing journals in classical Chinese]. Beijing: Zhonghua shuju, 2014. 302 pp., including three appendices and a reference bibliography. ISBN: 978-7101099430. Cross-Currents co-editor Wen-hsin Yeh (University of California, Berkeley discusses a contemporary Chinese commentary on the Yŏnhaeng-nok (Ch. Yanxinglu, Journeys to Beijing, a collection of Chosŏn-era travelogues written by Korean envoys to China (specifically, Beijing.

  4. Solid-state amorphization of SmFe{sub 3} by hydrogenation

    Energy Technology Data Exchange (ETDEWEB)

    Mueller, K.H.; Kubis, M.; Handstein, A.; Gutfleisch, O.


    Hydrogen-induced amorphization (HIA) has received much attention as a method for the preparation of amorphous compounds since its discovery by Yeh et al. Meanwhile it has been observed for a large number of intermetallic compounds with C15, C23, B8{sub 2}, DO{sub 19} and L1{sub 2} structures. E.G. the C15 Laves-type compounds (MgCu{sub 2}-type structure) of rare earth (R) - transition metal (T) compounds RT{sub 2} show HIA for R = Y, Ce, Pr, Nd, Sm, Gd, Tb, Dy, Ho and Er. Aoki et al. postulated that new amorphizing compounds can be expected at high hydrogen pressures. In this work, the structural changes of SmFe{sub 3} (PuNi{sub 3}-type structure) during heating in high hydrogen pressures are reported.

  5. Solid-state amorphization of SmFe3 by hydrogenation

    International Nuclear Information System (INIS)

    Mueller, K.H.; Kubis, M.; Handstein, A.; Gutfleisch, O.


    Hydrogen-induced amorphization (HIA) has received much attention as a method for the preparation of amorphous compounds since its discovery by Yeh et al. Meanwhile it has been observed for a large number of intermetallic compounds with C15, C23, B8 2 , DO 19 and L1 2 structures. E.G. the C15 Laves-type compounds (MgCu 2 -type structure) of rare earth (R) - transition metal (T) compounds RT 2 show HIA for R = Y, Ce, Pr, Nd, Sm, Gd, Tb, Dy, Ho and Er. Aoki et al. postulated that new amorphizing compounds can be expected at high hydrogen pressures. In this work, the structural changes of SmFe 3 (PuNi 3 -type structure) during heating in high hydrogen pressures are reported

  6. Study of Travelling Interplanetary Phenomena (STIP) workshop travel (United States)

    Wu, S. T.


    Thirty six abstracts are provided from the SCOSTEP/STIP Symposium on Retrospective Analyses and Future Coordinated Intervals held in Switzerland on June 10 to 12, 1985. Six American scientists participated in the symposium and their abstracts are also included. The titles of their papers are: (1) An analysis of near surface and coronal activity during STIP interval 12, by T. E. Gergely; (2) Helios images of STIP intervals 6, B. V. Jackson; (3) Results from the analysis of solar and interplanetary observations during STIP interval 7, S. R. Kane; (4) STIP interval 19, E. Cliver; (5) Hydrodynamic buoyancy force in the solar atmosphere, T. Yeh; and (6) A combined MHD modes for the energy and momentum transport from solar surface to interplanetary space, S. T. Wu.


    Directory of Open Access Journals (Sweden)

    Katia Buffetrille


    Full Text Available Emily Yeh and Chris Coggins have gathered a collection of ten articles published under what appears as a very contradictory title: Mapping Shangrila. Contested Landscapes in the Sino-Tibetan Borderlands. Since Peter Bishop's The Myth of Shangri la (1989 and Donald Lopez's Prisoners of Shangri la (1998, several books have appeared on Tibet and its relation with the mythical realm created by James Hilton (1900-1954. Meanwhile, Tibetans and Chinese officials in Yunnan have succeeded in establishing Hilton's imaginary place on earth in a real place, populated by real people. In 2002, the city of Gyalthang (Rgyal thang; Ch, Zhongdian, was renamed Shangrila, or Xiangelila as it is rendered in Chinese language. The Shangrila of this book covers a geographic area much larger than Rgyal thang and its surroundings, however. It deals with what the editors qualify as the "Sino-Tibetan Borderlands": places in Kham and Amdo that are undertaking a similar process of "Shangrilazation." ..

  8. Updating radon daughter bronchial dosimetry

    International Nuclear Information System (INIS)

    Harley, N.H.; Cohen, B.S.


    It is of value to update radon daughter bronchial dosimetry as new information becomes available. Measurements have now been performed using hollow casts of the human bronchial tree with a larynx to determine convective or turbulent deposition in the upper airways. These measurements allow a more realistic calculation of bronchial deposition by diffusion. Particle diameters of 0.15 and 0.2 μm were used which correspond to the activity median diameters for radon daughters in both environmental and mining atmospheres. The total model incorporates Yeh/Schum bronchial morphometry, deposition of unattached and attached radon daughters, build up and decay of the daughters and mucociliary clearance. The alpha dose to target cells in the bronchial epithelium is calculated for the updated model and compared with previous calculations of bronchial dose

  9. La création séparation comme œuvre de l'origine


    Wénin, André


    La séparation est l'opération adéquate permettant de sortir du chaos. Or, en Genèse 1, quand Dieu met en œuvre son propre nom en disant Yehî, il sépare. Mais ce qui se passe ainsi au commencement a lieu aussi dans l'histoire. D'autres commencements s'y produisent, comme on le voit au début de l'aventure d'Abraham (Gn 12) ou de Moïse (Ex 3), dans l'exode du peuple sortant d'Égypte (Ex 14) et lors de la conclusion de l'alliance au Sinaï (Ex 19-20). A chaque fois, en intimant une séparation, la ...

  10. Review Essay: Knowing Society, Cultivating Citizens, and Making the State in Post-Imperial China

    Directory of Open Access Journals (Sweden)

    Robert Culp


    Full Text Available Tong Lam. A Passion for Facts: Social Surveys and the Construction of the Chinese Nation-State, 1900–1949. Berkeley: University of California Press, 2011. 280 pp. $60 (cloth.Janet Y. Chen. Guilty of Indigence: The Urban Poor in China, 1900–1953. Princeton: Princeton University Press, 2012. 320 pp. $45 (cloth/eBook.Understanding society and building the national community were, in many ways, paired common goals for China’s intellectuals and political leaders during the first half of the twentieth century. Complementary new books by Tong Lam and Janet Chen illuminate key dynamics of those processes. Lam’s A Passion for Facts: Social Surveys and the Construction of the Chinese Nation-State, 1900–1949 tracks the development of the social survey movement (shehui diaocha yundong during the first half of the twentieth century. Chen’s Guilty of Indigence: The Urban Poor in China, 1900–1953 analyzes efforts to explain poverty, categorize the poor, and extend to the needy “active relief,” which was meant to transform them from “parasites” into productive citizens. Together the books demonstrate how new systems of knowledge served to map the social field and how institutions of governance defined and reshaped social groups for the project of national mobilization, with Lam concentrating more on the development of modern technologies of knowledge and Chen focusing more on the development of governmental institutions and the imposition of social discipline. Through their analyses these books help to explain the process whereby abstract academic fields and research methodologies, along with theories and techniques of social governance, had material effects that transformed millions of people’s daily lives. They provide, in other words, striking examples of what Wen-hsin Yeh, Eddy U, and I have elsewhere characterized as “organized knowledge in action” (Culp, U, and Yeh n.d....

  11. Etude sur la prédiction de l'inversion de phase Phase Inversion Behavior for Liquid Dispersions

    Directory of Open Access Journals (Sweden)

    Decarre S.


    Full Text Available En écoulement diphasique eau-huile dans lequel une des phases est dispersée dans l'autre, il peut se produire sous certaine condition d'écoulement une inversion de phase, la phase continue devenant dispersée. Ce phénomène, qui contrôle la nature de la phase mouillant la paroi de la conduite dans laquelle s'écoulent les phases, a des conséquences importantes sur la corrosion et sur la perte de charge. Nous présentons un modèle d'inversion, basé sur une approche thermodynamique, valable pour tous les régimes d'écoulement. Les données expérimentales utilisées pour la validation du modèle sont issues d'une étude bibliographique. En écoulement laminaire, cette approche conduit à des résultats similaires à ceux du modèle de Yeh. Pour la plupart des données disponibles, ce modèle prédit bien la fraction critique pour laquelle l'inversion de phase se produit. In two phase oil-water dispersed flow, a phase inversion may occur whereby the continuous phase becomes dispersed. This phenomenon which controls the nature of the phase in contact with the pipe has a great importance on the corrosion and on the pressure drop. A model for the phase inversion is presented, it is based on a thermodynamic approach, and it is valid for all flow regimes. Experimental data from the litterature are used to validate the model. In laminar flow, this approach gives similar results to those obtained by Yeh. For most data, the model agrees well with the experimental data.

  12. Morphodynamics structures induced by variations of the channel width (United States)

    Duro, Gonzalo; Crosato, Alessandra; Tassi, Pablo


    In alluvial channels, forcing effects, such as a longitudinally varying width, can induce the formation of steady bars (Olesen, 1984). The type of bars that form, such as alternate, central or multiple, will mainly depend on the local flow width-to-depth ratio and on upstream conditions (Struiksma et al., 1985). The effects on bar formation of varying the channel width received attention only recently and investigations, based on flume experiments and mathematical modelling, are mostly restricted to small longitudinal sinusoidal variations of the channel width (e.g. Repetto et al., 2002; Wu and Yeh, 2005, Zolezzi et al., 2012; Frascati and Lanzoni, 2013). In this work, we analyze the variations in equilibrium bed topography in a longitudinal width-varying channel with characteristic scales of the Waal River (The Netherlands) using two different 2D depth-averaged morphodynamic models, one based on the Delft3D code and one on Telemac-Mascaret system. In particular, we explore the effects of changing the wavelength of sinusoidal width variations in a straight channel, focusing on the effects of the spatial lag between bar formation and forcing that is observed in numerical models and laboratory experiments (e.g. Crosato et al, 2011). We extend the investigations to finite width variations in which longitudinal changes of the width-to-depth ratio are such that they may affect the type of bars that become unstable (alternate, central or multiple bars). Numerical results are qualitatively validated with field observations and the resulting morphodynamic pattern is compared with the physics-based predictor of river bar modes by Crosato and Mosselman (2009). The numerical models are finally used to analyse the experimental conditions of Wu and Yeh (2005). The study should be seen as merely exploratory. The aim is to investigate possible approaches for future research aiming at assessing the effects of artificial river widening and narrowing to control bar formation in

  13. Sensitivity of the solution of the Elder problem to density, velocity and numerical perturbations (United States)

    Park, Chan-Hee; Aral, Mustafa M.


    In this paper the Elder problem is studied with the purpose of evaluating the inherent instabilities associated with the numerical solution of this problem. Our focus is first on the question of the existence of a unique numerical solution for this problem, and second on the grid density and fluid density requirements necessary for a unique numerical solution. In particular we have investigated the instability issues associated with the numerical solution of the Elder problem from the following perspectives: (i) physical instability issues associated with density differences; (ii) sensitivity of the numerical solution to idealization irregularities; and, (iii) the importance of a precise velocity field calculation and the association of this process with the grid density levels that is necessary to solve the Elder problem accurately. In the study discussed here we have used a finite element Galerkin model we have developed for solving density-dependent flow and transport problems, which will be identified as TechFlow. In our study, the numerical results of Frolkovič and de Schepper [Frolkovič, P. and H. de Schepper, 2001. Numerical modeling of convection dominated transport coupled with density-driven flow in porous media, Adv. Water Resour., 24, 63-72.] were replicated using the grid density employed in their work. We were also successful in duplicating the same result with a less dense grid but with more computational effort based on a global velocity estimation process we have adopted. Our results indicate that the global velocity estimation approach recommended by Yeh [Yeh, G.-T., 1981. On the computation of Darcian velocity and mass balance in finite element modelling of groundwater flow, Water Resour. Res., 17(5), 1529-1534.] allows the use of less dense grids while obtaining the same accuracy that can be achieved with denser grids. We have also observed that the regularity of the elements in the discretization of the solution domain does make a difference

  14. Endovascular Repair of an Actively Hemorrhaging Stab Wound Injury to the Abdominal Aorta

    International Nuclear Information System (INIS)

    Hussain, Qasim; Maleux, Geert; Heye, Sam; Fourneau, Inge


    Traumatic injury of the abdominal aorta is rare and potentially lethal (Yeh et al., J Vasc Surg 42(5):1007-1009, 2005; Chicos et al., Chirurgia (Bucur) 102(2):237-240, 2007) as it can result in major retroperitoneal hemorrhage, requiring an urgent open surgery. In case of concomitant bowel injury or other conditions of hostile abdomen, endovascular repair can be an alternative treatment. This case report deals with a 50-year-old man presenting at the emergency ward with three stab wounds: two in the abdomen and one in the chest. During explorative laparotomy, liver laceration and bowel perforation were repaired. One day later, abdominal CT-scan revealed an additional retroperitoneal hematoma associated with an aortic pseudoaneurysm, located anteriorly 3 cm above the aortic bifurcation. Because of the risk of graft infection, an endovascular repair of the aortic injury using a Gore excluder stent-graft was performed. Radiological and clinical follow-up revealed a gradual shrinkage of the pseudo-aneurysm and no sign of graft infection at two years' follow-up.

  15. Reaction-Based Reactive Transport Modeling of Iron Reduction and Uranium Immobilization at Area 2 of the NABIR Field Research Center, Subproject to Co-PI Eric E. Roden. Final Report

    International Nuclear Information System (INIS)

    Roden, Eric E.


    This report summarizes research conducted in conjunction with a project entitled 'Reaction-Based Reactive Transport Modeling of Iron Reduction and Uranium Immobilization at Area 2 of the NABIR Field Research Center', which was funded through the Integrative Studies Element of the former NABIR Program (now the Environmental Remediation Sciences Program) within the Office of Biological and Environmental Research. Dr. William Burgos (The Pennsylvania State University) was the overall PI/PD for the project, which included Brian Dempsey (Penn State), Gour-Tsyh (George) Yeh (Central Florida University), and Eric Roden (formerly at The University of Alabama, now at the University of Wisconsin) as separately-funded co-PIs. The project focused on development of a mechanistic understanding and quantitative models of coupled Fe(III)/U(VI) reduction in FRC Area 2 sediments. The work builds on our previous studies of microbial Fe(III) and U(VI) reduction, and was directly aligned with the Scheibe et al. ORNL FRC Field Project at Area 2.

  16. A study of usability principles and interface design for mobile e-books. (United States)

    Wang, Chao-Ming; Huang, Ching-Hua


    This study examined usability principles and interface designs in order to understand the relationship between the intentions of mobile e-book interface designs and users' perceptions. First, this study summarised 4 usability principles and 16 interface attributes, in order to conduct usability testing and questionnaire survey by referring to Nielsen (1993), Norman (2002), and Yeh (2010), who proposed the usability principles. Second, this study used the interviews to explore the perceptions and behaviours of user operations through senior users of multi-touch prototype devices. The results of this study are as follows: (1) users' behaviour of operating an interactive interface is related to user prior experience; (2) users' rating of the visibility principle is related to users' subjective perception but not related to user prior experience; however, users' ratings of the ease, efficiency, and enjoyment principles are related to user prior experience; (3) the interview survey reveals that the key attributes affecting users' behaviour of operating an interface include aesthetics, achievement, and friendliness. This study conducts experiments to explore the effects of users’ prior multi-touch experience on users’ behaviour of operating a mobile e-book interface and users’ rating of usability principles. Both qualitative and quantitative data analyses were performed. By applying protocol analysis, key attributes affecting users’ behaviour of operation were determined.

  17. Three-dimensional semi-analytical solution to groundwater flow in confined and unconfined wedge-shaped aquifers (United States)

    Sedghi, Mohammad Mahdi; Samani, Nozar; Sleep, Brent


    The Laplace domain solutions have been obtained for three-dimensional groundwater flow to a well in confined and unconfined wedge-shaped aquifers. The solutions take into account partial penetration effects, instantaneous drainage or delayed yield, vertical anisotropy and the water table boundary condition. As a basis, the Laplace domain solutions for drawdown created by a point source in uniform, anisotropic confined and unconfined wedge-shaped aquifers are first derived. Then, by the principle of superposition the point source solutions are extended to the cases of partially and fully penetrating wells. Unlike the previous solution for the confined aquifer that contains improper integrals arising from the Hankel transform [Yeh HD, Chang YC. New analytical solutions for groundwater flow in wedge-shaped aquifers with various topographic boundary conditions. Adv Water Resour 2006;26:471-80], numerical evaluation of our solution is relatively easy using well known numerical Laplace inversion methods. The effects of wedge angle, pumping well location and observation point location on drawdown and the effects of partial penetration, screen location and delay index on the wedge boundary hydraulic gradient in unconfined aquifers have also been investigated. The results are presented in the form of dimensionless drawdown-time and boundary gradient-time type curves. The curves are useful for parameter identification, calculation of stream depletion rates and the assessment of water budgets in river basins.

  18. 1986 annual information meeting. Abstracts

    International Nuclear Information System (INIS)


    Abstracts are presented for the following papers: Geohydrological Research at the Y-12 Plant (C.S. Haase); Ecological Impacts of Waste Disposal Operations in Bear Creek Valley Near the Y-12 Plant (J.M. Loar); Finite Element Simulation of Subsurface Contaminant Transport: Logistic Difficulties in Handling Large Field Problems (G.T. Yeh); Dynamic Compaction of a Radioactive Waste Burial Trench (B.P. Spalding); Comparative Evaluation of Potential Sites for a High-Level Radioactive Waste Repository (E.D. Smith); Changing Priorities in Environmental Assessment and Environmental Compliance (R.M. Reed); Ecology, Ecotoxicology, and Ecological Risk Assessment (L.W. Barnthouse); Theory and Practice in Uncertainty Analysis from Ten Years of Practice (R.H. Gardner); Modeling Landscape Effects of Forest Decline (V.H. Dale); Soil Nitrogen and the Global Carbon Cycle (W.M. Post); Maximizing Wood Energy Production in Short-Rotation Plantations: Effect of Initial Spacing and Rotation Length (L.L. Wright); and Ecological Communities and Processes in Woodland Streams Exhibit Both Direct and Indirect Effects of Acidification (J.W. Elwood)

  19. Improving the Authentication Scheme and Access Control Protocol for VANETs

    Directory of Open Access Journals (Sweden)

    Wei-Chen Wu


    Full Text Available Privacy and security are very important in vehicular ad hoc networks (VANETs. VANETs are negatively affected by any malicious user’s behaviors, such as bogus information and replay attacks on the disseminated messages. Among various security threats, privacy preservation is one of the new challenges of protecting users’ private information. Existing authentication protocols to secure VANETs raise challenges, such as certificate distribution and reduction of the strong reliance on tamper-proof devices. In 2011, Yeh et al. proposed a PAACP: a portable privacy-preserving authentication and access control protocol in vehicular ad hoc networks. However, PAACP in the authorization phase is breakable and cannot maintain privacy in VANETs. In this paper, we present a cryptanalysis of an attachable blind signature and demonstrate that the PAACP’s authorized credential (AC is not secure and private, even if the AC is secretly stored in a tamper-proof device. An eavesdropper can construct an AC from an intercepted blind document. Any eavesdropper can determine who has which access privileges to access which service. For this reason, this paper copes with these challenges and proposes an efficient scheme. We conclude that an improving authentication scheme and access control protocol for VANETs not only resolves the problems that have appeared, but also is more secure and efficient.

  20. Integrated Modeling of Groundwater and Surface Water Interactions in a Manmade Wetland

    Directory of Open Access Journals (Sweden)

    Guobiao Huang Gour-Tsyh Yeh


    Full Text Available A manmade pilot wetland in south Florida, the Everglades Nutrient Removal (ENR project, was modeled with a physics-based integrated approach using WASH123D (Yeh et al. 2006. Storm water is routed into the treatment wetland for phosphorus removal by plant and sediment uptake. It overlies a highly permeable surficial groundwater aquifer. Strong surface water and groundwater interactions are a key component of the hydrologic processes. The site has extensive field measurement and monitoring tools that provide point scale and distributed data on surface water levels, groundwater levels, and the physical range of hydraulic parameters and hydrologic fluxes. Previous hydrologic and hydrodynamic modeling studies have treated seepage losses empirically by some simple regression equations and, only surface water flows are modeled in detail. Several years of operational data are available and were used in model historical matching and validation. The validity of a diffusion wave approximation for two-dimensional overland flow (in the region with very flat topography was also tested. The uniqueness of this modeling study is notable for (1 the point scale and distributed comparison of model results with observed data; (2 model parameters based on available field test data; and (3 water flows in the study area include two-dimensional overland flow, hydraulic structures/levees, three-dimensional subsurface flow and one-dimensional canal flow and their interactions. This study demonstrates the need and the utility of a physics-based modeling approach for strong surface water and groundwater interactions.

  1. Application of the finite element groundwater model FEWA to three regional aquifers

    International Nuclear Information System (INIS)

    Wong, K.F.V.; Yeh, G.T.


    This report documents the calibration with field data and predictive application of a finite element model of water through aquifers (FEWA). FEWA was described in a report written by G.T. Yeh and D.D. Huff in 1983. The model was first compared with the United States Geological Survey (USGS) two-dimensional model and found superior in treating anisotropic media when the coordinates cannot be made to coincide with the principal directions of hydraulic conductivities. In addition, there was no necessity to define nodal points outside the region, as required by the USGS model. FEWA was next calibrated with measured potentiometric surfaces from the Love Canal area in New York and the Conesville area in Ohio. There were satisfactory matches between computed results and available field data. The calibration and predictive runs of FEWA were then accomplished with the Hialeah-Preston well field data over the Biscayne aquifer in south Florida. The calibration run yielded two values of hydraulic conductivity in the area, and the predictive run gave results that matched well with available data. 18 refs., 28 figs

  2. Social Networks and the Maintenance of Conformity: Japanese sojourner women. (United States)

    Saint Arnault, Denise; Roles, Deborah J


    Asian immigrant women have the lowest utilization of mental health services of any ethnic minority (Garland, Lau, Yeh & McCabe 2005). Because help seeking for distress occurs within social networks, we examined how social networks supported or disabled help seeking for Japanese sojourners living in the US. Unfortunately, most of the literature about Japanese social relationships focuses on men in organizational settings. This study used intensive ethnographic interviewing with 49 Japanese expatriate women to examine how social relationships influenced psychosocial distress and help seeking. We found that the women in these samples engaged in complex, highly regulated, complicated and obligatory relationships through their primary affiliation with other "company wives." Like many immigrant women, increased traditional cultural norms (referred to in Japanese as ryoosai kenbo, or good wives and wise mothers), were expected from these modern women, and the enactment of these roles was enforced through scrutiny, gossip and the possibility of ostracism. Fears of scrutiny was described by the women as a primary barrier to their self-disclosure and ultimate help seeking. Understanding the social organization and support within the Japanese women's community is central to understanding how culturally specific social networks can both give support, as well as create social constraints to help seeking. Health oriented prevention programs must consider these social factors when evaluating the immigration stressors faced by these families.

  3. Acute parietal lobe infarction presenting as Gerstmann’s syndrome and cognitive decline mimicking senile dementia

    Directory of Open Access Journals (Sweden)

    Chen TY


    Full Text Available Tien-Yu Chen,1 Chun-Yen Chen,1,3 Che-Hung Yen,2,3 Shin-Chang Kuo,1,3 Yi-Wei Yeh,1,3 Serena Chang,1 San-Yuan Huang1,31Department of Psychiatry, 2Department of Neurology, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, 3Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan, Republic of ChinaAbstract: Gerstmann’s syndrome encompasses the tetrad of finger agnosia, agraphia, acalculia, and right-left confusion. An elderly man with a history of several cardiovascular diseases was initially brought to the psychiatric outpatient department by his family because of worsening of recent memory, executive function, and mixed anxious-depressive mood. Gerstmann’s syndrome without obvious motor function impairment and dementia-like features could be observed at first. Emergent brain computed tomography scan revealed new left-middle cerebral artery infarction over the left posterior parietal lobe. This case reminds us that acute cerebral infarction involving the parietal lobe may present as Gerstmann’s syndrome accompanied by cognitive decline mimicking dementia. As a result, emergent organic workups should be arranged, especially for elderly patients at high risk for cerebral vascular accident.Keywords: Gerstmann’s syndrome, dementia, parietal lobe infarction

  4. Upper bound for the span of pencil graph (United States)

    Parvathi, N.; Vimala Rani, A.


    An L(2,1)-Coloring or Radio Coloring or λ coloring of a graph is a function f from the vertex set V(G) to the set of all nonnegative integers such that |f(x) ‑ f(y)| ≥ 2 if d(x,y) = 1 and |f(x) ‑ f(y)| ≥ 1 if d(x,y)=2, where d(x,y) denotes the distance between x and y in G. The L(2,1)-coloring number or span number λ(G) of G is the smallest number k such that G has an L(2,1)-coloring with max{f(v) : v ∈ V(G)} = k. [2]The minimum number of colors used in L(2,1)-coloring is called the radio number rn(G) of G (Positive integer). Griggs and yeh conjectured that λ(G) ≤ Δ2 for any simple graph with maximum degree Δ>2. In this article, we consider some special graphs like, n-sunlet graph, pencil graph families and derive its upper bound of (G) and rn(G).

  5. The simulation of a two-dimensional (2D) transport problem in a rectangular region with Lattice Boltzmann method with two-relaxation-time (United States)

    Sugiyanto, S.; Hardyanto, W.; Marwoto, P.


    Transport phenomena are found in many problems in many engineering and industrial sectors. We analyzed a Lattice Boltzmann method with Two-Relaxation Time (LTRT) collision operators for simulation of pollutant moving through the medium as a two-dimensional (2D) transport problem in a rectangular region model. This model consists of a 2D rectangular region with 54 length (x), 27 width (y), and it has isotropic homogeneous medium. Initially, the concentration is zero and is distributed evenly throughout the region of interest. A concentration of 1 is maintained at 9 < y < 18, whereas the concentration of zero is maintained at 0 < y < 9 and 18 < y < 27. A specific discharge (Darcy velocity) of 1.006 is assumed. A diffusion coefficient of 0.8333 is distributed uniformly with a uniform porosity of 0.35. A computer program is written in MATLAB to compute the concentration of pollutant at any specified place and time. The program shows that LTRT solution with quadratic equilibrium distribution functions (EDFs) and relaxation time τa=1.0 are in good agreement result with other numerical solutions methods such as 3DLEWASTE (Hybrid Three-dimensional Lagrangian-Eulerian Finite Element Model of Waste Transport Through Saturated-Unsaturated Media) obtained by Yeh and 3DFEMWATER-LHS (Three-dimensional Finite Element Model of Water Flow Through Saturated-Unsaturated Media with Latin Hypercube Sampling) obtained by Hardyanto.

  6. Application of the finite element groundwater model FEWA to three regional aquifers

    Energy Technology Data Exchange (ETDEWEB)

    Wong, K.F.V.; Yeh, G.T.


    This report documents the calibration with field data and predictive application of a finite element model of water through aquifers (FEWA). FEWA was described in a report written by G.T. Yeh and D.D. Huff in 1983. The model was first compared with the United States Geological Survey (USGS) two-dimensional model and found superior in treating anisotropic media when the coordinates cannot be made to coincide with the principal directions of hydraulic conductivities. In addition, there was no necessity to define nodal points outside the region, as required by the USGS model. FEWA was next calibrated with measured potentiometric surfaces from the Love Canal area in New York and the Conesville area in Ohio. There were satisfactory matches between computed results and available field data. The calibration and predictive runs of FEWA were then accomplished with the Hialeah-Preston well field data over the Biscayne aquifer in south Florida. The calibration run yielded two values of hydraulic conductivity in the area, and the predictive run gave results that matched well with available data. 18 refs., 28 figs.

  7. Estimating back to front ratio of wire screen for measurement of thoron decay products

    International Nuclear Information System (INIS)

    Koli, Amruta; Khandare, Pallavi; Joshi, Manish; Mariam; Khan, Arshad; Sapra, B.K.


    Wire screens are widely used for measuring the fine fraction of radon/thoron decay products. Their capture efficiencies are generally defined at low aerosol concentration conditions as well as at low sampling flow rates. Effect of changes in sampling flow rate and aerosol concentration on wire screen capture efficiencies and counting correction factor has been studied in this work. Controlled experiments have been conducted using two different mesh sizes at two different aerosol concentration conditions. Experimental results were compared with the existing theories for capture efficiencies of wire screens given by Cheng and Yeh (1980) and Alonso et al. (2001); and semi empirical relation for the front to total ratio given by Solomon and Ren (1992). Theoretical predictions have been found to be relatively close to the experimental findings for moderate aerosol conditions but disagreement was observed in case of high aerosol concentration. The possible reasons for these differences have been discussed in this work. - Highlights: • Effect of Fiber Reynolds number on capture efficiency and back to front ratio of wire screen. • Experiments with Thoron decay products at moderate and elevated aerosol concentrations. • Comparison with theoretical estimates. • Fair agreement observed for moderate aerosol concentration.

  8. A novel glycated hemoglobin A1c-lowering traditional Chinese medicinal formula, identified by translational medicine study.

    Directory of Open Access Journals (Sweden)

    Hsin-Yi Lo

    Full Text Available Diabetes is a chronic metabolic disorder that has a significant impact on the health care system. The reduction of glycated hemoglobin A1c is highly associated with the improvements of glycemic control and diabetic complications. In this study, we identified a traditional Chinese medicinal formula with a HbA1c-lowering potential from clinical evidences. By surveying 9,973 diabetic patients enrolled in Taiwan Diabetic Care Management Program, we found that Chu-Yeh-Shih-Kao-Tang (CYSKT significantly reduced HbA1c values in diabetic patients. CYSKT reduced the levels of HbA1c and fasting blood glucose, and stimulated the blood glucose clearance in type 2 diabetic mice. CYSKT affected the expressions of genes associated with insulin signaling pathway, increased the amount of phosphorylated insulin receptor in cells and tissues, and stimulated the translocation of glucose transporter 4. Moreover, CYSKT affected the expressions of genes related to diabetic complications, improved the levels of renal function indexes, and increased the survival rate of diabetic mice. In conclusion, this was a translational medicine study that applied a "bedside-to-bench" approach to identify a novel HbA1c-lowering formula. Our findings suggested that oral administration of CYSKT affected insulin signaling pathway, decreased HbA1c and blood glucose levels, and consequently reduced mortality rate in type 2 diabetic mice.

  9. Study of the nonequilibrium state of superconductors by large quasiparticle injection from an external current source

    International Nuclear Information System (INIS)

    Iguchi, I.


    We have studied the nonequilibrium state of superconductors by injecting large numbers of quasiparticles from an external current source into a superconducting film of a tunnel junction with low tunnel resistance (typically 0.1--1 Ω for junction area approx. = 10 -4 cm 2 ). It was observed that there was a critical tunnel current density at which a voltage appeared locally in the part of a superconducting film confined to the junction area. Its values ranged from 10 2 to 10 3 A/cm 2 for bath temperatures well below T/sub c/. Followed by this voltage onset, a transition region corresponding to the nonequilibrium intermediate resistive state was also observed. For further increase of the tunnel current, the local film resistance developed beyond the value of its normal resistance, suggesting that the nonequilibrium state extends far beyond the voltage onset point. A theory based on the modified Rothwarf-Taylor equations and Parker's T* model is presented to compare with the experimental results. The calculated critical current density yielded almost the same order of magnitude as those found experimentally. The detailed behavior, however, deviates from the theoretical predictions although the film makes a second-order transition in the broad range of temperatures. It is also shown using four-terminal analysis that our observations and those by Wong, Yeh, and Langenberg are essentially the same

  10. System-size corrections for self-diffusion coefficients calculated from molecular dynamics simulations: The case of CO{sub 2}, n-alkanes, and poly(ethylene glycol) dimethyl ethers

    Energy Technology Data Exchange (ETDEWEB)

    Moultos, Othonas A.; Economou, Ioannis G. [Chemical Engineering Program, Texas A& M University at Qatar, P.O. Box 23847, Doha (Qatar); Zhang, Yong; Maginn, Edward J., E-mail: [Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, Indiana 46556 (United States); Tsimpanogiannis, Ioannis N. [Chemical Engineering Program, Texas A& M University at Qatar, P.O. Box 23847, Doha (Qatar); Environmental Research Laboratory, National Center for Scientific Research “Demokritos,” 15310 Aghia Paraskevi Attikis (Greece)


    Molecular dynamics simulations were carried out to study the self-diffusion coefficients of CO{sub 2}, methane, propane, n-hexane, n-hexadecane, and various poly(ethylene glycol) dimethyl ethers (glymes in short, CH{sub 3}O–(CH{sub 2}CH{sub 2}O){sub n}–CH{sub 3} with n = 1, 2, 3, and 4, labeled as G1, G2, G3, and G4, respectively) at different conditions. Various system sizes were examined. The widely used Yeh and Hummer [J. Phys. Chem. B 108, 15873 (2004)] correction for the prediction of diffusion coefficient at the thermodynamic limit was applied and shown to be accurate in all cases compared to extrapolated values at infinite system size. The magnitude of correction, in all cases examined, is significant, with the smallest systems examined giving for some cases a self-diffusion coefficient approximately 15% lower than the infinite system-size extrapolated value. The results suggest that finite size corrections to computed self-diffusivities must be used in order to obtain accurate results.

  11. Age-dependent lung dosimetry of radon progeny

    International Nuclear Information System (INIS)

    Hofmann, W.; Martonen, T.B.; Menache, M.G.


    Two morphometric models differing in the tracheobronchial region, were compared in the present paper: Model 1 is based on the adult morphology of Weibel, assuming that all bronchial airways grow in equal proportion; while Model 2 adopts the adult structure proposed by Yeh and Schum, using measured airway dimensions in the right upper lobe as a function of age. Tidal volume and respiratory frequency also vary with age: while the breathing frequency decreases with rising age, tidal volume increases. Radiation doses in each bronchial airway generation were computed for the deep lying basal cells as well as for the more uniformly distributed serous (SMGS) cells, which are currently assumed to be the progenitor cells for bronchial carcinomas. Radiation doses to both target cells were significantly higher in the newborn than in the adult, for all simulated breathing patterns, showing the highest relative increase in upper bronchial airways. Comparing both tracheobronchial growth models, Model 1 predicts higher doses at early ages, but produced lower doses in the adult lung

  12. Reaction-Based Reactive Transport Modeling of Iron Reduction and Uranium Immobilization at Area 2 of the NABIR Field Research Center

    Energy Technology Data Exchange (ETDEWEB)

    Burgos, W.D.


    This report summarizes research conducted in conjunction with a project entitled “Reaction-Based Reactive Transport Modeling of Iron Reduction and Uranium Immobilization at Area 2 of the NABIR Field Research Center”, which was funded through the Integrative Studies Element of the former NABIR Program (now the Environmental Remediation Sciences Program) within the Office of Biological and Environmental Research. Dr. William Burgos (The Pennsylvania State University) was the overall PI/PD for the project, which included Brian Dempsey (Penn State), Gour-Tsyh (George) Yeh (Central Florida University), and Eric Roden (formerly at The University of Alabama, now at the University of Wisconsin) as separately-funded co-PIs. The project focused on development of a mechanistic understanding and quantitative models of coupled Fe(III)/U(VI) reduction in FRC Area 2 sediments. The work builds on our previous studies of microbial Fe(III) and U(VI) reduction, and was directly aligned with the Scheibe et al. ORNL FRC Field Project at Area 2.

  13. Dirac Coulomb Green's function and its application to relativistic Rayleigh scattering

    International Nuclear Information System (INIS)

    Wong, M.K.F.; Yeh, E.H.Y.


    The Dirac Coulomb Green's function is obtained in both coordinate and momentum space. The Green's function in coordinate space is obtained by the eigenfunction expansion method in terms of the wave functions obtained by Wong and Yeh. The result is simpler than those obtained previously by other authors, in that the radial part for each component contains one term only instead of four terms. Our Green's function reduces to the Schroedinger Green's function upon some simple conditions, chiefly by neglecting the spin and replacing lambda by l. The Green's function in momentum space is obtained as the Fourier transform of the coordinate space Green's function, and is expressed in terms of basically three types of functions: (1) F/sub A/ (α; β 1 β 2 β 3 ; γ 1 γ 2 γ 3 ; z 1 z 2 z 3 ), (2) the hypergeometric function, and (3) spherical harmonics. The matrix element for Rayleigh scattering, or elastic Compton scattering, from relativistically bound electrons is then obtained in analytically closed form. The matrix element is written basically in terms of the coordinate space Dirac Coulomb Green's function. The technique used in the evaluation of the matrix element is based on the calculation of the momentum space Dirac Coulomb Green's function. Finally the relativistic result is compared with the nonrelativistic result

  14. Comparing and improving proper orthogonal decomposition (POD) to reduce the complexity of groundwater models (United States)

    Gosses, Moritz; Nowak, Wolfgang; Wöhling, Thomas


    reduced model space, thereby allowing the recalculation of system matrices at every time-step necessary for non-linear models while retaining the speed of the reduced model. This makes POD-DEIM applicable for groundwater models simulating unconfined aquifers. However, in our analysis, the method struggled to reproduce variable river boundaries accurately and gave no advantage for variable Dirichlet boundaries compared to the original POD method. We have developed another extension for POD that targets to address these remaining problems by performing a second POD operation on the model matrix on the left-hand side of the equation. The method aims to at least reproduce the accuracy of the other methods where they are applicable while outperforming them for setups with changing river boundaries or variable Dirichlet boundaries. We compared the new extension with original POD and POD-DEIM for different combinations of model structures and boundary conditions. The new method shows the potential of POD extensions for applications to non-linear groundwater systems and complex boundary conditions that go beyond the current, relatively limited range of applications. References: Siade, A. J., Putti, M., and Yeh, W. W.-G. (2010). Snapshot selection for groundwater model reduction using proper orthogonal decomposition. Water Resour. Res., 46(8):W08539. Stanko, Z. P., Boyce, S. E., and Yeh, W. W.-G. (2016). Nonlinear model reduction of unconfined groundwater flow using pod and deim. Advances in Water Resources, 97:130 - 143.

  15. Effects of a selective educational system on fatigue, sleep problems, daytime sleepiness, and depression among senior high school adolescents in Taiwan

    Directory of Open Access Journals (Sweden)

    Chen TY


    Full Text Available Tien-Yu Chen,1,2 Yu-Ching Chou,3 Nian-Sheng Tzeng,1,2,4 Hsin-An Chang,1,2,4 Shin-Chang Kuo,1,2,5 Pei-Yin Pan,1,2 Yi-Wei Yeh,1,2,5 Chin-Bin Yeh,1,2 Wei-Chung Mao1,2,6 1Department of Psychiatry, Tri-Service General Hospital, 2School of Medicine, National Defense Medical Center, 3School of Public Health, National Defense Medical Center, 4Student Counseling Center, National Defense Medical Center, 5Graduate Institute of Medical Sciences, National Defense Medical Center, 6Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan, Republic of China Objective: The aim of the study reported here was to clarify the effects of academic pressure on fatigue, sleep problems, daytime sleepiness, and depression among senior high school adolescents in Taiwan. Methods: This cross-sectional study enrolled 757 senior high school adolescents who were classified into four groups: Grade 1 (n=261, Grade 2 (n=228, Grade 3T (n=199; Grade 3 students who had another college entrance test to take, and Grade 3S (n=69; Grade 3 students who had succeeded in their college application. Fatigue, sleep quality, daytime sleepiness, and depression were assessed using the Chinese version of the Multidimensional Fatigue Symptom Inventory – Short Form, Pittsburgh Sleep Quality Index-Taiwan Form, the Chinese version of the Epworth Sleepiness Scale, and the Chinese version of the Beck Depression Inventory®-II (BDI-II, respectively. Results: Physical, emotional, and mental fatigue scores were all higher in higher-grade groups. The Grade 3T (test students had the worst fatigue severity, and the Grade 3S (success students had the least fatigue severity. More than half of the students (60.9% went to bed after 12 am, and they had on average 6.0 hours of sleep per night. More than 30% of the students in Grade 2 (37.3% and Grades 3T/S (30.2%/30.4% possibly had daily sleepiness problems. The students in Grade 3T had the worst BDI-II score (13.27±9.24, and the Grade 3S

  16. Beneficial effects of prolonged blood pressure control after carotid artery stenting

    Directory of Open Access Journals (Sweden)

    Chang A


    Full Text Available Anna Chang,1 Huei-Fong Hung,2 Fang-I Hsieh,3 Wei-Hung Chen,1,4 Hsu-Ling Yeh,1,5 Jiann-Horng Yeh,1,6 Hou-Chang Chiu,1,6 Li-Ming Lien1,4 1Department of Neurology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, 2Department of Cardiology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, 3School of Public Health, College of Public Health, Taipei Medical University, Taipei, 4School of Medicine, College of Medicine, Taipei Medical University, Taipei, 5Institute of Public Health, National Yang-Ming University, Taipei, 6School of Medicine, College of Medicine, Fu Jen Catholic University, Taipei, Taiwan Objectives: The main purpose of this study was to investigate whether carotid artery stenting (CAS plus medicine in patients with severe carotid artery stenosis provide a better long-term blood pressure (BP control compared to other medical treatments alone. The other aim was to explore the correlation between post-CAS hypotension within 6 h and long-term BP reductions after CAS. Materials and methods: Patients with severe carotid stenosis were recruited either in the CAS group or in the medication group. BPs and the number of classes of antihypertensive agents were recorded at baseline, 6, and 12 months. Extra BP information was collected at 6 h, 3 days, and 1 month after CAS. Univariate and multivariate linear regressions were performed to test the relationship of BP changes among CAS and medication groups after 6 and 12 months of follow-up. Univariate linear regressions were also used to determine the correlations between the mean or maximal systolic BP (SBP reductions at 6 h and 1 year post-CAS. Results: In total, 72 members in the CAS group and 82 members in the medication group were recruited. Compared with the medication group, patients in the CAS group had greater BP reductions at 6 and 12 months of follow-up after adjusting for confounding factors (13.56 mmHg at 6 months, P=0.0002; 16.98 mmHg at 12 months, P<0.0001. This study also shows significant

  17. A comprehensive investigation of the pseudo-skin factor for partially completed vertical wells

    International Nuclear Information System (INIS)

    Farokhi, Vahid; Gerami, Shahab


    To prohibit gas and/or water coning, it is very common for wells to be completed over only a portion of their productive zone. Such a procedure causes an additional pressure drop, termed the pseudo-skin factor, which reduces the well productivity. In order to ascertain whether or not a partially penetrated well requires stimulation, one has to quantitatively determine the different components of the total skin. Hence, an accurate evaluation of the pseudo-skin factor as one of the main components of the total skin is critical. Many authors have employed different mathematics to find expressions for estimating the pseudo-skin factor, however, since a comprehensive investigation of the available models has not as yet been performed, the diversity of these expressions could be very confusing. This paper first aims to propose an analytical model which accurately estimates the pseudo-skin factor in a partially penetrated well. In model development, the impacts of anisotropy and the arbitrariness of the open interval location are all taken into account, and the model is validated against a numerical simulator (ECLIPSE). Its second aim is to take the results of the numerical simulator as the comparison basis, and make a comprehensive investigation of the available models to check their accuracy for estimating the pseudo-skin factor. The results of the investigation show that, in comparison to other methods, this proposed model, Streltsova's method and that of Yeh and Reynolds, estimate the pseudo-skin factor favourably close to that obtained by the simulator. (paper)

  18. Enhancement of tendon–bone healing via the combination of biodegradable collagen-loaded nanofibrous membranes and a three-dimensional printed bone-anchoring bolt

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    Chou YC


    Full Text Available Ying-Chao Chou,1,2 Wen-Lin Yeh,2 Chien-Lin Chao,1 Yung-Heng Hsu,1,2 Yi-Hsun Yu,1,2 Jan-Kan Chen,3 Shih-Jung Liu1,2 1Department of Mechanical Engineering, Chang Gung University, 2Department of Orthopedic Surgery, Chang Gung Memorial Hospital, 3Department of Physiology and Pharmacology, Chang Gung University, Taoyuan, Taiwan Abstract: A composite biodegradable polymeric model was developed to enhance tendon graft healing. This model included a biodegradable polylactide (PLA bolt as the bone anchor and a poly(D,L-lactide-co-glycolide (PLGA nanofibrous membrane embedded with collagen as a biomimic patch to promote tendon–bone interface integration. Degradation rate and compressive strength of the PLA bolt were measured after immersion in a buffer solution for 3 months. In vitro biochemical characteristics and the nanofibrous matrix were assessed using a water contact angle analyzer, pH meter, and tetrazolium reduction assay. In vivo efficacies of PLGA/collagen nanofibers and PLA bolts for tendon–bone healing were investigated on a rabbit bone tunnel model with histological and tendon pullout tests. The PLGA/collagen-blended nanofibrous membrane was a hydrophilic, stable, and biocompatible scaffold. The PLA bolt was durable for tendon–bone anchoring. Histology showed adequate biocompatibility of the PLA bolt on a medial cortex with progressive bone ingrowth and without tissue overreaction. PLGA nanofibers within the bone tunnel also decreased the tunnel enlargement phenomenon and enhanced tendon–bone integration. Composite polymers of the PLA bolt and PLGA/collagen nanofibrous membrane can effectively promote outcomes of tendon reconstruction in a rabbit model. The composite biodegradable polymeric system may be useful in humans for tendon reconstruction. Keywords: polylactide–polyglycolide nanofibers, PLGA, collagen, 3D printing, polylactide, PLA, bone-anchoring bolts, tendon healing

  19. Neglect of the foreign invisible: Historiography and the navigation of conflicting sensibilities. (United States)

    Burman, Jeremy Trevelyan


    This essay is intended first as a contribution to historiography, and only second as a contribution to the history of developmental psychology. It is therefore a discussion--primarily--of the doing of the history of psychology, rather than of its content. Briefly put: American psychology, including its associated approaches to the history of psychology, is not adequately equipped to benefit fully from the contributions of foreign scholars. To make the resulting argument clear, two archive-driven microhistories are reviewed, contrasted, augmented with new archival research, and synthesized: Yeh Hsueh's (2004) examination of the nomination process at Harvard University that led to the awarding of an honorary doctorate to Jean Piaget in 1936, and Marc Ratcliff and Paloma Borella's (2013) examination-just recently published in French-of a similar process that resulted in Piaget's hiring at Geneva in 1929 and his eventual promotion in 1940. Comparing the authors' different approaches to similar content then affords this article's larger argument: we need to broaden our sensibilities so we can see high-quality foreign contributions for what they are. Several interesting insights result if we do. Among them: although Piaget's theory is today mistakenly criticized for being asocial, and this serves as justification for countering his early works with Vygotsky's posthumous critique, it emerges from these archival studies that Piaget may have in fact chosen to present himself and his work as nonsociological (when this was not the case) for reasons unrelated to his intellectual project. Such examples then broaden the discussion of "neglect of the foreign invisible" to include suppression--even censorship (by self or other)--which in turn reflects the primary problem afforded by internationalization: by what standards are we to judge the contributions of "foreigners" into "our" discipline? (c) 2015 APA, all rights reserved).

  20. Angry characters and frightened souls: Patients and family explanatory models of bipolar disorder in Taiwan. (United States)

    Lan, Yi-Feng Carol; Zelman, Diane C; Chao, Wen-Tao


    Bipolar disorder (BD) affects a significant proportion of Taiwanese individuals (Weissman et al., 1996; Yang, Yeh, & Hwu, 2012). Psychotropic medications are typically the mainstay of treatment for BD, and there is an abundance of international research on biological etiology and medication options. However, there is comparatively little research on psychosocial aspects of BD, including how it is understood and managed within families. As culture provides the context in which psychiatric disease is managed, there is a need to identify distinct Chinese psychosocial perspectives that might shed light on intervention options. This research explored how Taiwanese patients and family members comprehend and cope with BD. A sample of 42 participants, including 20 Taiwanese patients diagnosed with Bipolar Disorder-I (BD-I) for at least 4 years, and 22 family members, participated in separate interviews on explanatory models of illness. Qualitative thematic analysis focused on features that were distinct from those in current Western research literature. Five themes were identified that represented Taiwanese conceptualizations of BD, notions of etiology, views regarding treatment, and the difficulties in managing the disorder. Participants used Chinese language terms and descriptions of BD that reflected greater concerns about irritability, anger, and family conflict than about other symptoms, and participants also emphasized characterological trait descriptions of the condition. Their responses reflected their acceptance of lifelong family responsibility for caretaking, clashing beliefs regarding biomedical versus traditional Chinese medical and spiritual models of etiology and cure, profound concerns about the effects of psychiatric medication on the liver and kidney systems, and a focus on stress rather than genetic or biological models of etiology.

  1. A randomized, double-blind, placebo-controlled study of oral antioxidant supplement therapy in patients with dry eye syndrome

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    Huang JY


    Full Text Available Jehn-Yu Huang, Po-Ting Yeh, Yu-Chih Hou Department of Ophthalmology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan Purpose: To evaluate the efficacy of oral antioxidant supplementation in the treatment of patients with dry eye syndrome (DES. Methods: A prospective, randomized, double-blinded study compared the effects of an antioxidant supplement (containing anthocyanosides, astaxanthin, vitamins A, C, and E, and several herbal extracts, including Cassiae semen and Ophiopogonis japonicus with placebo on patients with DES. We assessed dry eye symptoms, visual acuity, Schirmer’s test, tear film breakup time, cornea and conjunctiva fluorescein staining, serum anti-SSA/anti-SSB antibodies, and the level of reactive oxygen species (ROS in tears. The supplementation period was 8 weeks and patients were followed up every 4 weeks for 16 weeks. A linear mixed model was used to compare the groups, while within-group differences were tested by repeated-measures analysis of variance. Results: Forty-three patients, 20 and 23 in treatment and placebo groups, respectively, completed the study. Liver and renal functions were normal. Diastolic blood pressure decreased in the treatment group. There were no significant differences in systolic blood pressure, dry eye symptoms, serum anti-SSA and anti-SSB, visual acuity, intraocular pressure, or fluorescein corneal staining between the groups. Tear film breakup time scores and Schirmer’s test without topical anesthesia significantly improved in the treatment group. Tear ROS level differed between the groups and decreased after treatment. Overall subjective impression revealed a significant improvement with treatment compared with placebo. Conclusion: Oral antioxidant supplementations may increase tear production and improve tear film stability by reducing tear ROS. The vegetable-based antioxidant supplement used in this study is safe and can be utilized as

  2. Development of interactive graphic user interfaces for modeling reaction-based biogeochemical processes in batch systems with BIOGEOCHEM (United States)

    Chang, C.; Li, M.; Yeh, G.


    The BIOGEOCHEM numerical model (Yeh and Fang, 2002; Fang et al., 2003) was developed with FORTRAN for simulating reaction-based geochemical and biochemical processes with mixed equilibrium and kinetic reactions in batch systems. A complete suite of reactions including aqueous complexation, adsorption/desorption, ion-exchange, redox, precipitation/dissolution, acid-base reactions, and microbial mediated reactions were embodied in this unique modeling tool. Any reaction can be treated as fast/equilibrium or slow/kinetic reaction. An equilibrium reaction is modeled with an implicit finite rate governed by a mass action equilibrium equation or by a user-specified algebraic equation. A kinetic reaction is modeled with an explicit finite rate with an elementary rate, microbial mediated enzymatic kinetics, or a user-specified rate equation. None of the existing models has encompassed this wide array of scopes. To ease the input/output learning curve using the unique feature of BIOGEOCHEM, an interactive graphic user interface was developed with the Microsoft Visual Studio and .Net tools. Several user-friendly features, such as pop-up help windows, typo warning messages, and on-screen input hints, were implemented, which are robust. All input data can be real-time viewed and automated to conform with the input file format of BIOGEOCHEM. A post-processor for graphic visualizations of simulated results was also embedded for immediate demonstrations. By following data input windows step by step, errorless BIOGEOCHEM input files can be created even if users have little prior experiences in FORTRAN. With this user-friendly interface, the time effort to conduct simulations with BIOGEOCHEM can be greatly reduced.

  3. Diversity of Shiga Toxin-Producing Escherichia coli (STEC) O26:H11 Strains Examined via stx Subtypes and Insertion Sites of Stx and EspK Bacteriophages (United States)

    Bonanno, Ludivine; Loukiadis, Estelle; Mariani-Kurkdjian, Patricia; Oswald, Eric; Garnier, Lucille; Michel, Valérie


    Shiga toxin-producing Escherichia coli (STEC) is a food-borne pathogen that may be responsible for severe human infections. Only a limited number of serotypes, including O26:H11, are involved in the majority of serious cases and outbreaks. The main virulence factors, Shiga toxins (Stx), are encoded by bacteriophages. Seventy-four STEC O26:H11 strains of various origins (including human, dairy, and cattle) were characterized for their stx subtypes and Stx phage chromosomal insertion sites. The majority of food and cattle strains possessed the stx1a subtype, while human strains carried mainly stx1a or stx2a. The wrbA and yehV genes were the main Stx phage insertion sites in STEC O26:H11, followed distantly by yecE and sbcB. Interestingly, the occurrence of Stx phages inserted in the yecE gene was low in dairy strains. In most of the 29 stx-negative E. coli O26:H11 strains also studied here, these bacterial insertion sites were vacant. Multilocus sequence typing of 20 stx-positive or stx-negative E. coli O26:H11 strains showed that they were distributed into two phylogenetic groups defined by sequence type 21 (ST21) and ST29. Finally, an EspK-carrying phage was found inserted in the ssrA gene in the majority of the STEC O26:H11 strains but in only a minority of the stx-negative E. coli O26:H11 strains. The differences in the stx subtypes and Stx phage insertion sites observed in STEC O26:H11 according to their origin might reflect that strains circulating in cattle and foods are clonally distinct from those isolated from human patients. PMID:25819955

  4. Reducing drug–herb interaction risk with a computerized reminder system

    Directory of Open Access Journals (Sweden)

    Lin SS


    Full Text Available Sheng-Shing Lin,1,2 Chiu-Lin Tsai,3 Ching-Yeh Tu,3 Ching-Liang Hsieh2,4,5 1Graduate Institute of Chinese Medicine, College of Chinese Medicine, China Medical University, 2Department of Chinese Medicine, China Medical University Hospital, 3Division of Chinese Medicine, Department of Pharmacy, China Medical University Hospital, 4Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, 5Research Center for Chinese Medicine and Acupuncture, China Medical University, Taichung, Taiwan Background: Traditional Chinese medicine (TCM and Western medicine are both popular in Taiwan. Approximately 14.1% of Taiwanese residents use Western drugs and Chinese herbs concurrently; therefore, drug–herb interaction is critical to patient safety. This paper presents a new procedure for reducing the risk of drug interactions.Methods: Hospital computer systems are modified to ensure that drug–herb interactions are automatically detected when a TCM practitioner is writing a prescription. A pop-up reminder appears, warning of interactions, and the practitioner may adjust doses, delete herbs, or leave the prescription unchanged. A pharmacist will receive interaction information through the system and provide health education to the patient.Results: During the 2011–2013 study period, 256 patients received 891 herbal prescriptions with potential drug–herb interactions. Three of the 50 patients who concurrently used ginseng and antidiabetic drugs manifested hypoglycemia (fasting blood sugar level ≤70 mg/dL.Conclusion: Drug–herb interactions can cause adverse reactions. A computerized reminder system can enable TCM practitioners to reduce the risk of drug–herb interactions. In addition, health education for patients is crucial in avoiding adverse reaction by the interactions. Keywords: Traditional Chinese medicine, Western medicine, adverse reaction

  5. دور وسائل الإعلام في مكافحة الفساد العراق أنموذجاً The Role Of The Media In The Fight Against Corruption Iraq as a Model

    Directory of Open Access Journals (Sweden)

    Hatem Bedaiwi Al-Shammari حاتم بديوي الشمري


    Full Text Available still the phenomenon of corruption is a threat to citizens in all parts of the globe and growing pressure in his living and limit his freedom and became one of the most serious risks that threaten life everywhere, as far as the corruption of the factors and causes of the spread remains the media 's role to eliminate it because of its active role in raising awareness and disclosure of his hideouts and mroger and reduce zhardh through matnqlh media diverse and specialized audience of news and events variety, which is one of the main functions to him, hence the relationship between the media and society, if the media have a directive in its destruction and the warning in a broad sense so described methods of the most dangerous methods are not very effective and with a broad impact, according to media definition as an attempt to influence the minds of the masses and their souls and to control their behavior , so the address is ( the media the role of our research in the fight against the phenomenon of corruption in iraq model are searching three sections included the first part , the research methodology of the problem and the importance of the objectives and methodology and terminology as well as research tools and assumptions. the second section on corruption its causes the forms, methods and ways of its spread and the third section to ensure the media 's role in reducing these phenomenon outlined goals and means media yeh to limit this phenomenon in addition the findings and recommendations and sources for research.

  6. The ubiquitin-homology protein, DAP-1, associates with tumor necrosis factor receptor (p60) death domain and induces apoptosis. (United States)

    Liou, M L; Liou, H C


    The tumor necrosis factor receptor, p60 (TNF-R1), transduces death signals via the association of its cytoplasmic domain with several intracellular proteins. By screening a mammalian cDNA library using the yeast two-hybrid cloning technique, we isolated a ubiquitin-homology protein, DAP-1, which specifically interacts with the cytoplasmic death domain of TNF-R1. Sequence analysis reveals that DAP-1 shares striking sequence homology with the yeast SMT3 protein that is essential for the maintenance of chromosome integrity during mitosis (Meluh, P. B., and Koshland, D. (1995) Mol. Biol. Cell 6, 793-807). DAP-1 is nearly identical to PIC1, a protein that interacts with the PML tumor suppressor implicated in acute promyelocytic leukemia (Boddy, M. N., Howe, K., Etkin, L. D., Solomon, E., and Freemont, P. S. (1996) Oncogene 13, 971-982), and the sentrin protein, which associates with the Fas death receptor (Okura, T., Gong, L., Kamitani, T., Wada, T., Okura, I., Wei, C. F., Chang, H. M., and Yeh, E. T. (1996) J. Immunol. 157, 4277-4281). The in vivo interaction between DAP-1 and TNF-R1 was further confirmed in mammalian cells. In transient transfection assays, overexpression of DAP-1 suppresses NF-kappaB/Rel activity in 293T cells, a human kidney embryonic carcinoma cell line. Overexpression of either DAP-1 or sentrin causes apoptosis of TNF-sensitive L929 fibroblast cell line, as well as TNF-resistant osteosarcoma cell line, U2OS. Furthermore, the dominant negative Fas-associated death domain protein (FADD) protein blocks the cell death induced by either DAP-1 or FADD. Collectively, these observations highly suggest a role for DAP-1 in mediating TNF-induced cell death signaling pathways, presumably through the recruitment of FADD death effector.

  7. Study on corrosion resistance of high - entropy alloy in medium acid liquid and chemical properties

    International Nuclear Information System (INIS)

    Florea, I; Buluc, G; Florea, R M; Carcea, I; Soare, V


    High-entropy alloy is a new alloy which is different from traditional alloys. The high entropy alloys were started in Tsing Hua University of Taiwan since 1995 by Yeh et al. Consisting of a variety of elements, each element occupying a similar compared with other alloy elements to form a high entropy. We could define high entropy alloys as having approximately equal concentrations, made up of a group of 5 to 11 major elements. In general, the content of each element is not more than 35% by weight of the alloy. During the investigation it turned out that this alloy has a high hardness and is also corrosion proof and also strength and good thermal stability. In the experimental area, scientists used different tools, including traditional casting, mechanical alloying, sputtering, splat-quenching to obtain the high entropy alloys with different alloying elements and then to investigate the corresponding microstructures and mechanical, chemical, thermal, and electronic performances. The present study is aimed to investigate the corrosion resistance in a different medium acid and try to put in evidence the mechanical properties. Forasmuch of the wide composition range and the enormous number of alloy systems in high entropy alloys, the mechanical properties of high entropy alloys can vary significantly. In terms of hardness, the most critical factors are: hardness/strength of each composing phase in the alloy, distribution of the composing phases. The corrosion resistance of an high entropy alloy was made in acid liquid such as 10%HNO 3 -3%HF, 10%H 2 SO 4 , 5%HCl and then was investigated, respectively with weight loss experiment. Weight loss test was carried out by put the samples into the acid solution for corrosion. The solution was maintained at a constant room temperature. The liquid formulations used for tests were 3% hydrofluoric acid with 10% nitric acid, 10% sulphuric acid, 5% hydrochloric acid. Weight loss of the samples was measured by electronic scale. (paper)

  8. Electroretinographic findings in transplant chorioretinopathy

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    Brian T Chan-Kai


    Full Text Available Brian T Chan-Kai1, Steven Yeh2, Richard G Weleber2, Peter J Francis2, Grazyna Adamus2, S Robert Witherspoon3, Andreas K Lauer11Cullen Eye Institute, Baylor College of Medicine, Houston, Texas; 2Casey Eye Institute, Oregon Health and Science University, Portland, Oregon; 3Retina Institute of Texas, Dallas, Texas, USAAim: Transplant chorioretinopathy is a rare complication following solid organ or bone ­marrow transplantation and can result in severe vision loss. This series presents electroretinogram (ERG results in patients with this condition.Methods: Patients who presented with bilateral vision loss following bone marrow or solid organ transplantation were identified. A complete ophthalmologic examination, fundus ­photography, and fluorescein angiography (FA were performed. Full-field ERG was obtained in all patients and a multifocal ERG (mfERG was obtained in two patients.Results: Four patients were identified. All patients had bilateral vision loss and displayed a characteristic pattern of mottled hyperfluorescence on FA. Three patients developed ­progressive vision loss ranging from 20/60 to hand motions whereas one retained 20/40 vision. All patients exhibited moderate to severe cone dysfunction, while the degree of rod abnormalities was varied. Two patients with severe cone dysfunction showed mild clinical changes initially, but later developed progressive vision loss and chorioretinal atrophy.Conclusion: Transplant chorioretinopathy patients undergoing ERG testing show cone ­dysfunction with a variable degree of rod dysfunction. ERG abnormalities preceded the visual acuity and clinical changes in two patients, suggesting that ERG may be a helpful predictor of the clinical course in this rare disease.Keywords: transplant, chorioretinopathy, electroretinogram, ERG, mfERG

  9. The preparation and characterization of gold-conjugated polyphenol nanoparticles as a novel delivery system

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    Hsieh DS


    Full Text Available Dar-Shih Hsieh1,2, Hsiu-Chin Lu5, Cheng-Cheung Chen1,3, Chang-Jer Wu1,*, Ming-Kung Yeh4,* 1Department of Food Science, National Taiwan Ocean University, Keelung, Taiwan; 2Division of Urology, 3Department of Pathology, Tri-Service General Hospital, 4Institute of Preventive Medicine, National Defence Medical Center, Taipei, Taiwan; 5Department of Laboratory Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan*These authors contributed equally to this workAbstract: Nanogold particles are commonly used in nanomedicine. We generated physical nanogold (pNG conjugated with different ratios of epigallocatechin-3-gallate (EGCG and evaluated its physicochemical properties, antioxidant activity, and cytotoxicity in vitro as well as anticancer activity in vivo. Results showed that the EGCG-pNG conjugates were successfully prepared at ratios between 23:1 and 23:5, with the percentage of EGCG content increasing with the EGCG:pNG ratio from 23:1 (2.0% ± 0.02% to 23:5 (28% ± 0.3%. EGCG-pNG particles at ratios of 23:1 and 23:5 demonstrated significantly decreased size from 500 to 20 nm and decreasing zeta potentials of 21 mV to –22 mV, respectively. At a ratio of 23:2.5, the EGCG-pNG particles (27% EGCG, 50 nm in size, zeta potential of –8 mV showed longer EGCG activity half-life (110 days vs 5 hours, controlled release (2 hours vs 30 minutes, and higher antioxidant activity (four times, as well as inhibition of tumor cell growth, than controls. The present study indicated that EGCG-pNG possesses promising therapeutic potential, based on its strong free-radical scavenging and anticancer activities.Keywords: EGCG, nanoparticles, antioxidant, antitumor activity, nanogold


    Directory of Open Access Journals (Sweden)

    Reviewed by Bill Bleisch


    Full Text Available Liu Jianqiang (Ian Rowen, Cyrus K Hui, and Emily T Yeh, translators 2015. Tibetan Environmentalists in China: The King of Dzi. Lanham, Boulder, New York, London: Lexington Books. xxi + 327 pp, index. ISBN 978-0-7391-9973-2 (hardback 105USD - ISBN 978-0-7391-9974-9 (electronic 103.35USD. This translation is an edited and updated version of Sky Beads - Tibetan Legends by Chinese journalist Liu Jianqiang, an accomplished investigative reporter (Fowler and Dean 2006; Shapiro 2016:126. The author began work on the book in 2006 when he was a visiting scholar at Peking University. He subsequently conducted a series of lengthy in-depth interviews with several remarkable individuals from various regions of Tibet - Tashi Dorje Hashi (Tador; Rukai Karma Samdrup (Karma and his older brother, Rinchen Samdrup (Rinchen; Tsewang Gendun Denba (Gendun, Musuo Lobsang Tsundru (Musuo, and others. What may have begun for the author as an investigation of local Tibetan environmental activism soon became something very different and more interesting: an exploration of the "remarkable lives" of individuals who had chosen to play a vibrant part in shaping the present and future of their home. The book explores not only their activities and thoughts on environmental and cultural conservation, but how these were shaped by their pasts and their current beliefs. The narrative digs unabashedly into all aspects of their lives, successes and mistakes, commitments and doubts. There is even an entire chapter devoted to the most intimate details of their complicated love lives, remarkable for the honesty and openness of the interviews.

  11. Quadro clínico do lobo orbitário com crises cerebelares: Cisticercose racemosa do ângulo ponto-cerebelar

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    Aníbal Silveira


    após a primeira discussão clínica do quadro, quando obtido o exame completo do líquor, o diagnóstico etiológico pôde ser aventado. O exame neuro-oftalmológico foi ainda negativo. A evolução dos sintomas levou o doente à obnubilação e ao embotamento intelectuais, à espurcícia; e, pelo lado neurológico, à impossibilidade de locomoção, à ataxia do tronco, ao relaxamento dos esfincteres. Diagnóstico: quadro neuropsiquiátrico orbitario, como repercussão de alterações ponto-cerebelares; cisticercose provável. O paciente faleceu 11 meses após a internação. A necropsia revelou, quanto ao sistema nervoso central, um cacho de vesículas de cisticerco racemoso ao nível do ângulo ponto-cerebelar direito (fig. 1 e espessamento das leptomeninges na base do encéfalo até a dos lobos temporais. Nenhuma alteração histológica do córtex cerebral ou das vias intra-hemisféricas (Nissl e Weil. Quanto ao aspecto patogênico, o quadro orbitario descrito por Kleist era representado pela falência na manutenção do esfôrço e da atividade em geral (Ausdauer, na regência instintiva dos atos (gesinnungsmässige Handlungen, bem como pelo distúrbio teatral, tipo pitiático, do caráter (Gesin-nung. Os transtornos neurológicos e mesmo neurovegetativos correspondiam, na opinião dos autores, à falência paleocerebelar.

  12. Identifying the hotspots of non-renewable water use using HiGW-MAT: A new land surface model coupled with human interventions and ground water reservoir (United States)

    Oki, T.; Pokhrel, Y. N.; Yeh, P. J.; Koirala, S.; Kanae, S.; Hanasaki, N.


    The real hydrological cycles on the Earth are not natural anymore. Global hydrological model simulations of the water cycle and available water resources should have an ability to consider the effects of human interventions on hydrological cycles. Anthropogenic activity modules (Hanasaki et al., 2008), such as reservoir operation, crop growth and water demand in crop lands, and environmental flows, were incorporated into a land surface model called MATSIRO (Takata et al., 2003), to form a new model, MAT-HI (Pokhrel et al., 2011). Total terrestrial water storages (TWS) in large river basins were estimated using the new model by off-line simulation, and compared with the TWS observed by GRACE for 2002-2007. The results showed MAT-HI has an advantage estimating TWS particularly in arid river basins compared with H08 (Hanasaki et al., 2008). MAT-HI was further coupled with a module representing the ground water level fluctuations (Yeh et al., 2005), and consists a new land surface scheme HiGW-MAT (Human Intervention and Ground Water coupled MATSIRO). HiGW-MAT is also associated with a scheme tracing the origin and flow path with the consideration on the sources of water withdrawal from stream flow, medium-size reservoirs and nonrenewable groundwater in addition to precipitation to croplands enabled the assessment of the origin of water producing major crops as Hanasaki et al. (2010). Areas highly dependent on nonrenewable groundwater are detected in the Pakistan, Bangladesh, western part of India, north and western parts of China, some regions in the Arabian Peninsula and the western part of the United States through Mexico. Cumulative nonrenewable groundwater withdrawals estimated by the model are corresponding fairly well with the country statistics of total groundwater withdrawals. Ground water table depletions in large aquifers in US estimated by HiGW-MAT were compared with in-situ observational data, and the correspondences are very good. Mean global exploitation

  13. Artificial Intelligence Learning Semantics via External Resources for Classifying Diagnosis Codes in Discharge Notes. (United States)

    Lin, Chin; Hsu, Chia-Jung; Lou, Yu-Sheng; Yeh, Shih-Jen; Lee, Chia-Cheng; Su, Sui-Lung; Chen, Hsiang-Cheng


    extracted enough concepts to predict the diagnosis codes. Word embedding combined with a CNN showed outstanding performance compared with traditional methods, needing very little data preprocessing. This shows that future studies will not be limited by incomplete dictionaries. A large amount of unstructured information from free-text medical writing will be extracted by automated approaches in the future, and we believe that the health care field is about to enter the age of big data. ©Chin Lin, Chia-Jung Hsu, Yu-Sheng Lou, Shih-Jen Yeh, Chia-Cheng Lee, Sui-Lung Su, Hsiang-Cheng Chen. Originally published in the Journal of Medical Internet Research (, 06.11.2017.

  14. Groundwater Salinity Simulation of a Subsurface Reservoir in Taiwan (United States)

    Fang, H. T.


    The subsurface reservoir is located in Chi-Ken Basin, Pescadores (a group islands located at western part of Taiwan). There is no river in these remote islands and thus the freshwater supply is relied on the subsurface reservoir. The basin area of the subsurface reservoir is 2.14 km2 , discharge of groundwater is 1.27×106m3 , annual planning water supplies is 7.9×105m3 , which include for domestic agricultural usage. The annual average temperature is 23.3oC, average moisture is 80~85%, annual average rainfall is 913 mm, but ET rate is 1975mm. As there is no single river in the basin; the major recharge of groundwater is by infiltration. Chi-Ken reservoir is the first subsurface reservoir in Taiwan. Originally, the water quality of the reservoir is good. The reservoir has had the salinity problem since 1991 and it became more and more serious from 1992 until 1994. Possible reason of the salinity problem was the shortage of rainfall or the leakage of the subsurface barrier which caused the seawater intrusion. The present study aimed to determine the leakage position of subsurface barrier that caused the salinity problem. In order to perform the simulation for different possible leakage position of the subsurface reservoir, a Groundwater Modeling System (GMS) is used to define soils layer data, hydro-geological parameters, initial conditions, boundary conditions and the generation of three dimension meshes. A three dimension FEMWATER(Yeh , 1996) numerical model was adopted to find the possible leakage position of the subsurface barrier and location of seawater intrusion by comparing the simulation of different possible leakage with the observations. 1.By assuming the leakage position in the bottom of barrier, the simulated numerical result matched the observation better than the other assumed leakage positions. It showed that the most possible leakage position was at the bottom of the barrier. 2.The research applied three dimension FEMWATER and GMS as an interface

  15. The Use of Benzodiazepine Receptor Agonists and Risk of Respiratory Failure in Patients with Chronic Obstructive Pulmonary Disease: A Nationwide Population-Based Case-Control Study (United States)

    Chen, Su-Jung; Yeh, Chiu-Mei; Chao, Tze-Fan; Liu, Chia-Jen; Wang, Kang-Ling; Chen, Tzeng-Ji; Chou, Pesus; Wang, Fu-Der


    Study Objectives: Insomnia is prevalent in patients with chronic obstructive pulmonary disease (COPD), and benzodiazepine receptor agonists (BZRAs) are the most commonly used drugs despite their adverse effects on respiratory function. The aim of this study was to investigate whether the use of BZRAs was associated with an increased risk of respiratory failure (RF) in COPD patients. Design: Matched case-control study. Setting: National Health Insurance Research Database (NHIRD) in Taiwan. Participants: The case group consisted of 2,434 COPD patients with RF, and the control group consisted of 2,434 COPD patients without RF, matched for age, sex, and date of enrollment. Measurements and Results: Exposure to BZRAs during the 180-day period preceding the index date was analyzed and compared in the case and control groups. Conditional logistic regression was performed, and the use of BZRAs was associated with an increased risk of RF (adjusted odds ratio [aOR] 1.56, 95% confidence interval [CI] 1.14–2.13). In subgroup analysis, we found that the benzodiazepine (BZD) users had a higher risk of RF (aOR 1.58, 95% CI 1.14–2.20), whereas the risk in non-benzodiazepine (non-BZD) users was insignificant (aOR 0.85, 95% CI 0.51–1.44). A greater than 2-fold increase in risk was found in those who received two or more kinds of BZRAs and those using a combination of BZD and non-BZD medications. Conclusions: The use of benzodiazepine receptor agonists was a significant risk factor for respiratory failure in patients with chronic obstructive pulmonary disease (COPD). Compared to benzodiazepine, the prescription of non-benzodiazepine may be safer for the management of insomnia in COPD patients. Citation: Chen SJ, Yeh CM, Chao TF, Liu CJ, Wang KL, Chen TJ, Chou P, Wang FD. The use of benzodiazepine receptor agonists and risk of respiratory failure in patients with chronic obstructive pulmonary disease: a nationwide population-based case-control study. SLEEP 2015;38(7):1045–1050

  16. Self-nanoemulsifying drug delivery systems ameliorate the oral delivery of silymarin in rats with Roux-en-Y gastric bypass surgery

    Directory of Open Access Journals (Sweden)

    Chen CH


    Full Text Available Chun-Han Chen,1,2 Cheng-Chih Chang,1 Tsung-Hsien Shih,2 Ibrahim A Aljuffali,3 Ta-Sen Yeh,4,5 Jia-You Fang6–8 1Division of General Surgery, Department of Surgery, Chang Gung Memorial Hospital, Chiayi, 2Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Kweishan, Taoyuan, Taiwan; 3Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia; 4Department of Surgery, Chang Gung Memorial Hospital, 5School of Medicine, College of Medicine, 6Pharmaceutics Laboratory, Graduate Institute of Natural Products, 7Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, 8Research Center for Industry of Human Ecology, Chang Gung University of Science and Technology, Kweishan, Taoyuan, Taiwan Abstract: Roux-en-Y gastric bypass (RYGB is a popular surgery to reduce the body weight of obese patients. Although food intake is restricted by RYGB, drug absorption is also decreased. The purpose of this study was to develop novel self-nanoemulsifying drug delivery systems (SNEDDS for enhancing the oral delivery of silymarin, which has poor water solubility. The SNEDDS were characterized by size, zeta potential, droplet number, and morphology. A technique of RYGB was performed in Sprague-Dawley rats. SNEDDS were administered at a silymarin dose of 600 mg/kg in normal and RYGB rats for comparison with silymarin aqueous suspension and polyethylene glycol (PEG 400 solution. Plasma silibinin, the main active ingredient in silymarin, was chosen for estimating the pharmacokinetic parameters. SNEDDS diluted in simulated gastric fluid exhibited a droplet size of 190 nm with a spherical shape. The nanocarriers promoted silibinin availability via oral ingestion in RYGB rats by 2.5-fold and 1.5-fold compared to the suspension and PEG 400 solution, respectively. A significant double-peak concentration of silibinin was detected for RYGB rats receiving SNEDDS. Fluorescence

  17. Secondary glaucoma in CAPN5-associated neovascular inflammatory vitreoretinopathy

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    Cham A


    Full Text Available Abdourahman Cham,1,2 Mayank Bansal,3 Himanshu K Banda,4 Young Kwon,1 Paul S Tlucek,1 Alexander G Bassuk,5 Stephen H Tsang,6,7 Warren M Sobol,8 James C Folk,1 Steven Yeh,4 Vinit B Mahajan1,2 1Department of Ophthalmology and Visual Sciences, 2Omics Laboratory, University of Iowa, Iowa City, IA, USA; 3Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India; 4Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA, 5Department of Pediatrics, University of Iowa, Iowa City, IA, 6Barbara and Donald Jonas Laboratory of Stem Cells and Regenerative Medicine and Bernard and Shirlee Brown Glaucoma Laboratory, Department of Pathology and Cell Biology, Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, 7Edward S Harkness Eye Institute, New York-Presbyterian Hospital, New York, NY, 8Retina Physicians & Surgeons, Inc., Dayton, OH, USA Objective: The objective of this study was to review the treatment outcomes of patients with secondary glaucoma in cases of autosomal dominant neovascular inflammatory vitreoretinopathy (ADNIV, a hereditary autoimmune uveitis due to mutations in CAPN5. Patients and methods: A retrospective, observational case series was assembled from ADNIV patients with secondary glaucoma. The main outcome measures were intraocular pressure (IOP, visual acuity, use of antiglaucoma medications, ocular surgeries, and adverse outcomes. Perimetry and optic disk optical coherence tomography (OCT were also analyzed. Results: Nine eyes of five ADNIV patients with secondary glaucoma were reviewed. Each received a fluocinolone acetonide (FA implant for the management of posterior uveitis. Following implantation, no eyes developed neovascular glaucoma. Five eyes (in patients 1, 2, and 5 required Ahmed glaucoma valve surgery for the management of steroid-responsive glaucoma. Patient 2 also developed angle closure with iris bombe and underwent laser

  18. Image-guided intensity-modulated radiotherapy for refractory bilateral breast cancer in a patient with extensive cutaneous metastasis in the chest and abdominal walls

    Directory of Open Access Journals (Sweden)

    Lu YF


    Full Text Available Yueh-Feng Lu,1 Yu-Chin Lin,2 Kuo-Hsin Chen,3,4 Pei-Wei Shueng,1 Hsin-Pei Yeh,1 Chen-Hsi Hsieh1,5,6 1Division of Radiation Oncology, Department of Radiology, 2Division of Oncology and Hematology, Department of Medicine, 3Department of Surgery, Far Eastern Memorial Hospital, New Taipei City, 4Department of Electrical Engineering, Yuan-Ze University, Taoyuan, 5Department of Medicine, 6Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan Abstract: Treatment for bilateral breast cancer with chest wall and abdominal skin invasion normally involves conventional radiotherapy (RT; however, conventional RT provides inadequate target volume coverage and excessive treatment of large volumes of normal tissue. Helical tomotherapy (HT has the ability to deliver continuous craniocaudal irradiation that suppresses junction problems and provides good conformity of dose distribution. A 47-year-old female with stage IV bilateral breast cancer with chest wall and pectoralis major muscle invasion, lymphadenopathy, bilateral pleural effusion, and multiple bone metastases received chemotherapy and target therapy beginning in January 2014; 4 months after the initiation of chemotherapy, computed tomography revealed progression of chest and abdominal wall invasion. A total dose of 70.2 Gy was delivered to both breasts, the chest wall, the abdominal wall, and the bilateral supraclavicular nodal areas in 39 fractions via HT. The total planning target volume was 4,533.29 cm3. The percent of lung volume receiving at least 20 Gy (V20 was 28%, 22%, and 25% for the right lung, left lung, and whole lung, respectively. The mean dose to the heart was 8.6 Gy. Follow-up computed tomography revealed complete response after the RT course. Grade 1 dysphagia, weight loss, grade 2 neutropenia, and grade 3 dermatitis were noted during the RT course. Pain score decreased from 6 to 1. No cardiac, pulmonary, liver, or intestinal toxicity

  19. Interpreting whether isoclinal folds are antiforms or synforms using FIA succession (United States)

    Cao, H.


    Using the asymmetries of the overprinting foliations preserved as inclusion trails that define the FIAs to investigate whether an enigmatic isoclinal fold in the region is an antiform or synform. This approach also reveals when the fold first formed during the tectonic history of the region. Multiply deformed and isoclinally folded interlayered high metamorphic grade gneisses and schists can be very difficult rocks for resolving early formed stratigraphic and structural relationships. When such rocks contain porphyroblasts a new approach is possible because of the way in which porphyroblast growth is affected by crenulation versus reactivation of compositional layering (Bell et al., 2003). Isoclinally folded rocks in the Arkansas River region of South Central Colorado contain relics of fold hinges that have been very difficult to ascertain whether they are antiforms or synforms because of younger refolding effects and the locally truncated nature of coarse compositional layering. With the realization that rocks with a schistosity parallel to bedding (S0 parallel S1) have undergone lengthy histories of deformation that predate the obvious first deformation (e.g. Bell et al., 2003; Sayab, 2006; Yeh, 2007) came recognition that large scale regional folds can form early during this process and be preserved throughout orogenesis (e.g., Ham and Bell, 2004; Bell and Newman, 2006. This extensive history is lost within the matrix because of reactivational shear on the compositional layering (Bell et al., 1998, 2003, 2004, 2005; Ham and Bell, 2004). However, it can be extracted by measuring FIAs. Recent work using this approach has revealed that the trends of axial planes of all map scale folds, when plotted on a rose diagram, strikingly reflect the FIA trends (e.g., Sanislav, 2009; Shah, 2009). That is, although it was demonstrated by Bell et al. (2003) that the largest scale regional folds commonly form early in the total history, other folds can form and be preserved from

  20. FOLFIRI and regorafenib combination therapy with dose escalation of irinotecan as fourth-line treatment for patients with metastatic colon cancer according to UGT1A1 genotyping

    Directory of Open Access Journals (Sweden)

    Lu CY


    Full Text Available Chien-Yu Lu,1,2 Yung-Sung Yeh,3–5 Ching-Wen Huang,5,6, Cheng-Jen Ma,4,5 Fang-Jung Yu,1,2 Jaw-Yuan Wang4–10 1Division of Gastroenterology, Department of Internal Medicine, 2Department of Internal Medicine, Faculty of Medicine, College of Medicine, 3Department of Emergency Medicine, Kaohsiung Municipal Hsiao-Kang Hospital, 4Graduate Institute of Clinical Medicine, College of Medicine, 5Division of Gastroenterology and General Surgery, Department of Surgery, Kaohsiung Medical University Hospital, 6Graduate Institute of Medicine, College of Medicine, 7Cancer Center, Kaohsiung Medical University Hospital, 8Department of Genomic Medicine, 9Department of Surgery, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; 10Center for Biomarkers and Biotech Drugs, Kaohsiung Medical University, Kaohsiung, Taiwan Abstract: Here we report a case of metastatic colon cancer treated with 5-fluorouracil, leucovorin, and escalated doses of irinotecan (FOLFIRI combined with regorafenib in the fourth-line setting after uridine diphosphate glucuronosyltransferase (UGT1A1 genotyping analysis. A 66-year-old male was initially diagnosed with Union Internationale Contre le Cancer stage III descending colon cancer and underwent curative surgery. He received postoperative adjuvant chemotherapy; however, liver metastasis developed and a partial hepatectomy was performed thereafter. Unfortunately, pulmonary metastases and recurrent liver tumors were found despite a series of systemic treatments with multiple combinations of cytotoxic and biologic agents. Recently, a novel multikinase inhibitor, regorafenib, was approved for the treatment of metastatic colorectal cancer refractory to other therapeutic modalities. As further treatment, we combined regorafenib with FOLFIRI, which included dose escalations of irinotecan, after UGT1A1 genotyping analysis. The therapeutic results were promising, with the improvement in liver and pulmonary metastases being

  1. Antiglycation, radical scavenging, and semicarbazide-sensitive amine oxidase inhibitory activities of acetohydroxamic acid in vitro

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    Liu YH


    Full Text Available Yuh-Hwa Liu,1,2,* Yeh-Lin Lu,3,* Der-Zen Liu,4 Wen-Chi Hou5 1Division of Gastroenterology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan; 2Department of General Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; 3Department of Pharmacy, Taipei Medical University, Taipei, Taiwan; 4Graduate Institute of Biomedical Materials and Tissue Engineering, Taipei Medical University, Taipei, Taiwan; 5Graduate Institute of Pharmacognosy, Taipei Medical University, Taipei, Taiwan *These authors contributed equally to this work Abstract: Advanced glycation endproducts (AGEs can promote intracellular reactive oxygen species production, and the levels of AGEs are highly correlated with cardiovascular disease and diabetes complications. Acetohydroxamic acid (acetH is a bacterial urease inhibitor drug used to treat kidney stones and infections in the urinary tract, and hydroxyurea (HU is a drug used for antineoplasm and sickle cell diseases. Both acetH and HU are hydroxamic acid derivatives. It was found that acetH and HU at 2.5 or 5 mM showed anti-AGE formation by lowering the AGEs’ fluorescent intensities and Nε-(carboxymethyllysine formation in bovine serum albumin/galactose models, and both showed better and significant differences (P<0.05 compared to the positive control of aminoguanidine. Regarding radical scavenging activities, the half-inhibition concentrations (IC50 of acetH against α,α-diphenyl-β-picrylhydrazyl radical and hydroxyl radical were 34.86 and 104.42 µM, respectively. The IC50 of acetH against semicarbazide-sensitive amine oxidase was 10.56 µM, and acetH showed noncompetitive inhibition respective to the substrates (benzylamine. The antiglycation, antioxidant, and semicarbazide-sensitive amine oxidase inhibitory activities of acetH prove that it has the potential for treating cardiovascular disease and diabetes complications and it needs further investigation in animal models. Keywords: acetH, AGEs, Nε

  2. Social support received by multidrug-resistant tuberculosis patients and related factors: a cross-sectional study in Zhejiang Province, People's Republic of China

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    Chen B


    Full Text Available Bin Chen,1 Yin Peng,1 Lin Zhou,1 Chengliang Chai,1 Hui-Chi Yeh,2 Songhua Chen,1 Fei Wang,1 Mingwu Zhang,1 Tieniu He,1 Xiaomeng Wang1 1Department of Tuberculosis Control and Prevention, Zhejiang Provincial Center for Disease Control and Prevention, Binjiang District, Hangzhou, People’s Republic of China; 2Politics & International Relations, Social Sciences, University of Southampton, Southampton, UK Objectives: The objective of this study is to assess the social support received by patients diagnosed with multidrug-resistant tuberculosis (MDR-TB in Zhejiang Province, People’s Republic of China and the factors that may have influenced it. Methods: A total of 220 MDR-TB patients participated in the questionnaire-based survey, and the data from 212 valid questionnaires were analyzed. The respondents reported their sociodemographic status, disease features, and attitudes toward the disease. The social support rating scale was used to measure the patients’ social support scores. An Independent Samples t-test, one-way analysis of variance, and a multiple linear regression model were used to analyze the related factors for the social support scores. Result: The average social support score of each MDR-TB patient was 32.56±7.86. Participants who were single, widowed or divorced, retired, and had fewer family members and lower family income were found to have lower social support scores. Participants unwilling to disclose their disease tended to have less social support (31.59<34.23, P=0.010. Participants who perceived great help from health care workers reported higher social support rating scale scores than those who perceived no help (35.36>29.89, P=0.014. Conclusion: MDR-TB patients in Zhejiang Province were shown to have a low level of social support. Patients who were not married, had smaller families, and lower family income received less social support, suggesting that family harmony could be an important source of social support. Patients

  3. Influence of charge on FITC-BSA-loaded chondroitin sulfate-chitosan nanoparticles upon cell uptake in human Caco-2 cell monolayers

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    Hu CS


    Full Text Available Chieh-shen Hu,1 Chiao-hsi Chiang,2 Po-da Hong,1,4,* Ming-kung Yeh1–3,*1Biomedical Engineering Program, Graduate Institute of Applied Science and Technology, National Taiwan University of Science and Technology; 2School of Pharmacy, National Defence Medical Center; 3Bureau of Pharmaceutical Affairs, Ministry of National Defence Medical Affairs Bureau; 4Department of Materials Science and Engineering, National Taiwan University of Science and Technology, Taiwan, Republic of China*These authors contributed equally to this workBackground and methods: Chondroitin sulfate-chitosan (ChS-CS nanoparticles and positively and negatively charged fluorescein isothiocyanate-conjugated bovine serum albumin (FITC-BSA-loaded ChS-CS nanoparticles were prepared and characterized. The properties of ChS-CS nanoparticles, including cellular uptake, cytotoxicity, and transepithelial transport, as well as findings on field emission-scanning electron microscopy, transmission electron microscopy, and confocal laser scanning microscopy were evaluated in human epithelial colorectal adenocarcinoma (Caco-2 fibroblasts. ChS-CS nanoparticles with a mean particle size of 250 nm and zeta potentials ranging from –30 to +18 mV were prepared using an ionic gelation method.Results: Standard cell viability assays demonstrated that cells incubated with ChS-CS and FITC-BSA-loaded ChS-CS nanoparticles remained more than 95% viable at particle concentrations up to 0.1 mg/mL. Endocytosis of nanoparticles was confirmed by confocal laser scanning microscopy and measured by flow cytometry. Ex vivo transepithelial transport studies using Caco-2 cells indicated that the nanoparticles were effectively transported into Caco-2 cells via endocytosis. The uptake of positively charged FITC-BSA-loaded ChS-CS nanoparticles across the epithelial membrane was more efficient than that of the negatively charged nanoparticles.Conclusion: The ChS-CS nanoparticles fabricated in this study were

  4. Hannibal Rosselli - professor of the Cracov Academy and author of "Pymander"

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    Wiesław Murawiec


    ; der Band V - dem polnischen König Stefan Batory; der Band VI /u.d.T. "Asclepius"/ - dem Erzbischof von Lemberg, Dan Dimitrij Solikowski; der Band IX - dem Kanonikus am Krakauer Dom Hieronymus Powodowski. Die übrigen fehlenden Bände /VII, VIII und X/ waren zwar druckfertig, erschienen jedoch nicht, auch die Manuskripte gingen verloren. Die ersten sechs Bände des "Pymander1’ erschienen dann noch einmal 1630 in Köln .in der Offizin des P. Cholinius, mitredigiert von F. Foix de Candal, einem klassischen Philologen. Rosselli stand in seiner Versöhnungsbereitschaft gegenüber anderen Konfessionen Erasmus von Rotterdam sehr nahe. Dennoch stiess er in Krakau auf keinen Widerstand, weder seitens seiner Mitbrüder noch seitens der Krakauer Professoren. Seine Widersacher, wie z.B. Podwodowski oder der Rektor der Universität, Jakub Görski, teilten zwar seine Einstellung nicht, begegnetem ihm aber stets mit grösser Freundlichkeit. Nicht ohne Bedeutung dürfte dabei der Umstand gewesen sein, dass Rosselli im Auftrag des Generalministers der Observanten nach Polen gekommen war und 1585 zum Generalkommissar und Visitator der polnischen Provinz zur Durchführung der tridentinischen Reform ernannt wurde. Im Bereich des Provinzkapitel in Warschau wurde 1585 eine Neuordnung des Studiums beschlossen und mit dem Lehrauf - trag jene Ordensbrüder betraut, die ihr Theologiestudium in Wilna abgeschlossen hatten. Rosselli machte sich einen Namen auch als Prediger. Zwei seiner Predigten sind uns in schriftlicher Form erhalten geblieben, die eine als Manuskript über die Auferstehung Christi aus dem Jahre 1582 /Ossolineum- Bibliothek, Hnds. 229, S. 123-129/, die andere wurde 1590 in Krakau u.d.T. "Oratio fuebralis ... in sepultra Stephani I Regis Poloniae. 1586" veröffentlicht. Die letztere hielt er bei der Bestattungszeremonie des polnischen Königs Bathory. Er soll auch bei der Krönung des Königs Sigismund III Waza gepredigt haben. Aus seiner Feder stammten weiters die uns heute

  5. Final Scientific/Technical Report - DE-FG02-06ER64172 - Reaction-Based Reactive Transport Modeling of Iron Reduction and Uranium Immobilization at Area 2 of the NABIR Field Research Center - Subproject to Co-PI Eric E. Roden

    International Nuclear Information System (INIS)

    Roden, Eric E.


    This report summarizes research conducted in conjunction with a project entitled 'Reaction-Based Reactive Transport Modeling of Iron Reduction and Uranium Immobilization at Area 2 of the NABIR Field Research Center', which was funded through the Integrative Studies Element of the former NABIR Program (now the Environmental Remediation Sciences Program) within the Office of Biological and Environmental Research. Dr. William Burgos (The Pennsylvania State University) was the overall PI/PD for the project, which included Brian Dempsey (Penn State), Gour-Tsyh (George) Yeh (Central Florida University), and Eric Roden (formerly at The University of Alabama, now at the University of Wisconsin) as separately-funded co-PIs. The project focused on development of a mechanistic understanding and quantitative models of coupled Fe(III)/U(VI) reduction in FRC Area 2 sediments. The work builds on our previous studies of microbial Fe(III) and U(VI) reduction, and was directly aligned with the Scheibe et al. ORNL FRC Field Project at Area 2. Area 2 is a shallow pathway for migration of contaminated groundwater to seeps in the upper reach of Bear Creek at ORNL, mainly through a ca. 1 m thick layer of gravel located 4-5 m below the ground surface. The gravel layer is sandwiched between an overlying layer of disturbed fill material, and 2-3 m of undisturbed shale saprolite derived from the underlying Nolichucky Shale bedrock. The fill was put in place when contaminated soils were excavated and replaced by native saprolite from an uncontaminated area within Bear Creek Valley; the gravel layer was presumably installed prior to addition of the fill in order to provide a stable surface for the operation of heavy machinery. The undisturbed saprolite is highly weathered bedrock that has unconsolidated character but retains much of the bedding and fracture structure of the parent rock (shale with interbedded limestone). Hydrological tracer studies conducted during the Scheibe et al. field

  6. Depression and family support in breast cancer patients

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    Su JA


    Full Text Available Jian-An Su,1–3,* Dah-Cherng Yeh,4,* Ching-Chi Chang,5,* Tzu-Chin Lin,6,7 Ching-Hsiang Lai,8 Pei-Yun Hu,8 Yi-Feng Ho,9 Vincent Chin-Hung Chen,1,2 Tsu-Nai Wang,10,11 Michael Gossop12 1Chang Gung Medical Foundation, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan; 2Department of Medicine, School of Medicine, Chang Gung University, Taoyuan, Taiwan; 3Department of Nursing, Chang Gung Institute of Technology, Taoyuan, Taiwan; 4Department of Surgery, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung, Taiwan; 5Institute of Medicine, Chung Shan Medical University and Department of Psychiatry, Chung Shan Medical University Hospital, Taichung, Taiwan; 6Department of Psychiatry, Chung Shan Medical University Hospital, Taichung, Taiwan; 7Department of Psychiatry, School of Medicine, Chung Shan Medical University, Taichung, Taiwan; 8Department of Medical Informatics, Chung Shan Medical University, Taichung, Taiwan; 9Tsaotun Psychiatric Center, Ministry of Health and Welfare, Nan-Tou,Taiwan; 10Department of Public Health, College of Health Science, Kaohsiung Medical University, Kaohsiung, Taiwan; 11Center of Excellence for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; 12King’s College London, Institute of Psychiatry, London, UK *These authors contributed equally to this work Background: Breast cancer is the most common cancer in women. Among the survivors, depression is one of the most common psychiatric comorbidities. This paper reports the point prevalence of major depressive disorder among breast cancer patients and the association between family support and major depressive disorder.Methods: Clinical data were collected from a breast cancer clinic of a general hospital in central Taiwan. Participants included 300 patients who were older than 18 years and diagnosed with breast cancer. Among these individuals, we used Mini International Neuropsychiatric Interview (a structural diagnostic tool for

  7. Tobacco-Smoking, Alcohol-Drinking, and Betel-Quid-Chewing Behaviors: Development and Use of a Web-Based Survey System. (United States)

    Hsu, Kuo-Yao; Tsai, Yun-Fang; Huang, Chu-Ching; Yeh, Wen-Ling; Chang, Kai-Ping; Lin, Chen-Chun; Chen, Ching-Yen; Lee, Hsiu-Lan


    family members or friends took 7.7 minutes (SD 2.8; range 3-18). Most of the participants completed the survey within 5-10 minutes. The Web-based survey was easy to self-administer. Health care providers can use this Web-based survey system to save time in assessing these risk behaviors in clinical settings. All smokers had mild-to-severe nicotine addiction, and 5.6%-12.3% of patients and their family members or friends were at risk of alcohol dependence. Considering that these three behaviors, particularly in combination, dramatically increase the risk of esophageal cancer, appropriate and convenient interventions are necessary for preserving public health in Taiwan. ©Kuo-Yao Hsu, Yun-Fang Tsai, Chu-Ching Huang, Wen-Ling Yeh, Kai-Ping Chang, Chen-Chun Lin, Ching-Yen Chen, Hsiu-Lan Lee. Originally published in JMIR Mhealth and Uhealth (, 11.06.2018.

  8. Importance-Performance Analysis of Personal Health Records in Taiwan: A Web-Based Survey. (United States)

    Rau, Hsiao-Hsien; Wu, Yi-Syuan; Chu, Chi-Ming; Wang, Fu-Chung; Hsu, Min-Huei; Chang, Chi-Wen; Chen, Kang-Hua; Lee, Yen-Liang; Kao, Senyeong; Chiu, Yu-Lung; Wen, Hsyien-Chia; Fuad, Anis; Hsu, Chien-Yeh; Chiu, Hung-Wen


    participants, 56.6%), with a monthly income of less than NT $30,000 (230 of 350 participants, 65.7%), and living in the North Taiwan (236 of 350 participants, 67.4%), with a good self-identified health status (171 of 350 participants, 48.9%). After performing the importance-performance analysis, we found the following: (1) instead of complex functions, people just want to have a platform that can let them integrate and manage their medical visit, health examination, and life behavior records; (2) they do not care whether their PHR is shared with others; and (3) most of the participants think the system security design is not important, but they also do not feel satisfied with the current security design. Overall, the issues receiving the most user attention were the system functions, circulation, integrity, ease of use, and continuity of the PHRs, data security, and privacy protection. ©Hsiao-Hsien Rau, Yi-Syuan Wu, Chi-Ming Chu, Fu-Chung Wang, Min-Huei Hsu, Chi-Wen Chang, Kang-Hua Chen, Yen-Liang Lee, Senyeong Kao, Yu-Lung Chiu, Hsyien-Chia Wen, Anis Fuad, Chien-Yeh Hsu, Hung-Wen Chiu. Originally published in the Journal of Medical Internet Research (, 27.04.2017.

  9. Physical Hydraulic Model of Side-Channel Spillway of Lambuk DAM, Bali (United States)

    Harifa, A. C.; Sholichin, M.; Othman, F. B.


    The spillway is among the most important structures of a dam project. A spillway is designed to prevent overtopping of a dam at a place that is not designed for overtopping. Side-channel spillways are commonly used to release water flow from a reservoir in places where the sides are steep and have a considerable height above the dam. Experimental results were collected with a hydraulic model of the side-channel spillway for releasing the peak overflow of Lambuk Dam. This dam is, located on the Lambuk River, which is a tributary of the Yeh Hoo River ~ 34.6 km north of Denpasar on the island of Bali. The bituminous geomembrane faced dam is 24 m in height, with a 35-m wide spillway. The length of the side channel is 35 m long, with 58 m of transition channel, 67.37 m of chuteway channel and 22.71 m of stilling basin. The capacity of the spillway is 231.91 m3/s and the outlet works capacity is 165.28 m3/s. The reservoir is designed for irrigation and water supply. The purpose of this study was to optimize the designed of the structure and to ensure its safe operation. In hydraulic model may help the decision-makers to visualize the flow field before selecting a ';suitable' design. The hydraulic model study was performed to ensure passage of the maximum discharge at maximum reservoir capacity; to study the spillway approach conditions, water surface profiles, and flow patterns in the chuteway; and to reveal potential demerits of the proposed hydraulic design of various structures and explore solutions. The model was constructed at 1 : 40 scale, Reservoir topography was modeled using concrete, the river bed using sand and some gravel, the river berm using concrete, and the spillway and channel using Plexiglas. Water was measured using Rectangular contracted weir. Design floods (with return period in year) were Q2 = 111.40 m3/s, Q5 = 136.84 m3/s, Q10 = 159.32 m3/s, Q25 = 174.61 m3/s, Q50 = 185.13 m3/s, Q100 = 198.08 m3/s, Q200 = 210.55 m3/s, Q1000 = 231.91 m3/s and the

  10. MART-10, a newly synthesized vitamin D analog, represses metastatic potential of head and neck squamous carcinoma cells

    Directory of Open Access Journals (Sweden)

    Yang SW


    Full Text Available Shih-Wei Yang,1,* Chi-Ying Tsai,2,* Yi-Chun Pan,3 Chun-Nan Yeh,4 Jong-Hwei S Pang,5 Masashi Takano,6 Atsushi Kittaka,6 Horng-Heng Juang,7 Tai C Chen,8 Kun-Chun Chiang4,9 1Department of Otolaryngology – Head and Neck Surgery, Chang Gung Memorial Hospital, Keelung, 2Department of Oral and Maxillofacial Surgery, Chang Gung Memorial Hospital, Taoyuan, 3Department of General Dentistry, Chang Gung Memorial Hospital, Chang Gung University, Keelung, 4General Surgery Department, Chang Gung Memorial Hospital, Keelung, 5Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan, Republic of China; 6Faculty of Pharmaceutical Sciences, Teikyo University, Tokyo, Japan; 7Department of Anatomy, College of Medicine, Chang Gung University, Taoyuan, Taiwan, Republic of China; 8Endocrine Core Laboratory, Boston University School of Medicine, Boston, MA, USA; 9Zebrafish Center, Chang Gung Memorial Hospital, Keelung, Taiwan, Republic of China *These authors contributed equally to this work Abstract: Even with multidisciplinary treatment, the prognosis and quality of life of patients diagnosed with head and neck squamous cell carcinoma (HNSCC are still not satisfactory. Previously, 19-Nor-2α-(3-hydroxypropyl-1α,25(OH2D3 (MART-10, the new brand 1α,25(OH2D3 analog, has been demonstrated to be an effective drug to inhibit HNSCC growth in vitro. Since most cancer patients die of metastasis, in this study, the antimetastatic effect of MART-10 on HNSCC was investigated. Our results reveal that both 1α,25(OH2D3 and MART-10 effectively repressed the migration and invasion of HNSCC cells, with MART-10 being much more potent than 1α,25(OH2D3. The antimetastatic effect of 1α,25(OH2D3 and MART-10 was mediated by attenuation of epithelial–mesenchymal transition (EMT, which was supported by the finding that the expression of EMT-inducing transcriptional factors, Sail and Twist, was inhibited by 1α,25(OH2D3 and MART

  11. Synthesis and evaluation of ortho-[18F]fluorocelecoxib for COX-2 cholangiocarcinoma imaging

    Directory of Open Access Journals (Sweden)

    Chang CW


    Full Text Available Chi-Wei Chang,1,* Chun-Nan Yeh,2,* Yi-Hsiu Chung,3,* Yong-Ren Chen,4 Shi-Wei Tien,4 Tsung-Wen Chen,2 Shiou-Shiow Farn,4,5 Ying-Cheng Huang,6 Chung-Shan Yu4,7 1Department of Nuclear Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; 2Department of Surgery, Liver Research Center, Chang-Gung Memorial Hospital at Linkou, Chang Gung University, Taoyuan, Taiwan; 3Center for Advanced Molecular Imaging and Translation, Chang Gung Memorial Hospital, Taoyuan, Taiwan; 4Department of Biomedical Engineering and Environmental Sciences, National Tsinghua University, Hsinchu, Taiwan; 5Isotope Application Division, Institute of Nuclear Energy Research, Taoyuan, Taiwan; 6Department of Neurosurgery, Chang-Gung Memorial Hospital at Linkou, Chang Gung University, Taoyuan, Taiwan; 7Institute of Nuclear Engineering and Science, National Tsinghua University, Hsinchu, Taiwan *These authors contributed equally to this work Background: An 18F-tagged NSAID analog was prepared for use as a probe for COX-2 expression, which is associated with tumor development. Methods: The in vivo uptake of celecoxib was monitored with ortho-[18F]fluorocelecoxib using positron emission tomography (PET. The binding affinity of ortho-[18F]fluorocelecoxib to COX-1 and COX-2 enzymes were assessed using the competitor celecoxib. Results: The IC50 values were 0.039 μM and 0.024 μM, respectively. A selectivity index of 1.63 was obtained (COX-2 vs COX-1. COX-2 overexpressed cholangiocarcinoma (CCA murine cells took up more ortho-[18F]fluorocelecoxib than that by usual CCA cells from 10 to 60 minutes post incubation. Competitive inhibition (blocking of the tracer uptake of ortho-[18F]fluorocelecoxib in the presence of celecoxib by the COX-2 overexpressed CCA cells and the usual CCA cells gave the IC50 values of 0.5 μM and 46.5 μM, respectively. Based on the in vitro accumulation data and in vivo metabolism half-life (30 min, PET scanning was performed 30–60 min after the

  12. Urban Vulnerability Assessment to Seismic Hazard through Spatial Multi-Criteria Analysis. Case Study: the Bucharest Municipality/Romania (United States)

    Armas, Iuliana; Dumitrascu, Silvia; Bostenaru, Maria


    conditions). In effect, the example of Bucharest demonstrates how the results shape the ‘vulnerability to seismic hazard profile of the city, based on which decision makers could develop proper mitigation strategies. To sum up, the use of an analytical framework as the standard Spatial Multi-Criteria Analysis (SMCA) - despite all difficulties in creating justifiable weights (Yeh et al., 1999) - results in accurate estimations of the state of the urban system. Although this method was often mistrusted by decision makers (Janssen, 2001), we consider that the results can represent, based on precisely the level of generalization, a decision support framework for policy makers to critically reflect on possible risk mitigation plans. Further study will lead to the improvement of the analysis by integrating a series of daytime and nighttime scenarios and a better definition of the constructed space variables.

  13. Design of acid-responsive polymeric nanoparticles for 7,3',4'-trihydroxyisoflavone topical administration

    Directory of Open Access Journals (Sweden)

    Huang PH


    Full Text Available Pao-Hsien Huang,1,* Stephen Chu-Sung Hu,2,3,* Chiang-Wen Lee,4,5 An-Chi Yeh,6 Chih-Hua Tseng,7 Feng-Lin Yen1,8,9 1Department of Fragrance and Cosmetic Science, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, 2Department of Dermatology, College of Medicine, Kaohsiung Medical University, Kaohsiung, 3Department of Dermatology, Kaohsiung Medical University Hospital, Kaohsiung, 4Research Center for Industry of Human Ecology, Chang Gung University of Science and Technology, Kweishan, Taoyuan, 5Department of Nursing, Division of Basic Medical Sciences, Chang Gung University of Science and Technology, Chia-Yi, 6Department of Cosmetics and Fashion Styling, Cheng Shiu University, Kaohsiung, 7School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, 8Lipid Science and Aging Research Center, Kaohsiung Medical University, Kaohsiung, 9Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan *These authors contributed equally to this work Abstract: 7,3',4'-Trihydroxyisoflavone (734THIF is a secondary metabolite of daidzein and has been recently found to possess antioxidant, melanin inhibition, and skin cancer chemopreventive activities. However, the poor water solubility of 734THIF impedes its absorption and skin penetration and, therefore, limits its pharmacological effects when applied topically to the skin. We seek to use the nanoprecipitation method to prepare optimal eudragit E100 (EE–polyvinyl alcohol (PVA-loaded 734THIF nanoparticles (734N to improve its physicochemical properties and thereby increase its water solubility, skin penetration, and biological activities. EE–PVA-loaded 734THIF nanoparticles (734N were prepared, and their morphology and particle size were evaluated using a particle size analyzer and by electron microscopy. The drug loading and encapsulation efficiencies and in vitro solubility were determined using high-performance liquid chromatography. Hydrogen

  14. Renal targeting potential of a polymeric drug carrier, poly-L-glutamic acid, in normal and diabetic rats

    Directory of Open Access Journals (Sweden)

    Chai HJ


    Full Text Available Hann-Juang Chai,1 Lik-Voon Kiew,1 Yunni Chin,1 Anwar Norazit,2 Suzita Mohd Noor,2 Yoke-Lin Lo,3,4 Chung-Yeng Looi,1 Yeh-Siang Lau,1 Tuck-Meng Lim,5 Won-Fen Wong,6 Nor Azizan Abdullah,1 Munavvar Zubaid Abdul Sattar,7 Edward J Johns,8 Zamri Chik,1 Lip-Yong Chung3 1Department of Pharmacology, 2Department of Biomedical Science, 3Department of Pharmacy, Faculty of Medicine, University of Malaya, 4School of Pharmacy, International Medical University, Kuala Lumpur, 5Department of Chemical Science, Faculty of Science, Universiti Tunku Abdul Rahman, Kampar, 6Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, 7School of Pharmaceutical Sciences, Universiti Sains Malaysia, Minden, Malaysia; 8Department of Physiology, University College Cork, Cork, Republic of Ireland Background and purpose: Poly-L-glutamic acid (PG has been used widely as a carrier to deliver anticancer chemotherapeutics. This study evaluates PG as a selective renal drug carrier.Experimental approach: 3H-deoxycytidine-labeled PGs (17 or 41 kDa and 3H-deoxycytidine were administered intravenously to normal rats and streptozotocin-induced diabetic rats. The biodistribution of these compounds was determined over 24 h. Accumulation of PG in normal kidneys was also tracked using 5-(aminoacetamido fluorescein (fluoresceinyl glycine amide-labeled PG (PG-AF. To evaluate the potential of PGs in ferrying renal protective anti-oxidative stress compounds, the model drug 4-(2-aminoethylbenzenesulfonyl fluoride hydrochloride (AEBSF was conjugated to 41 kDa PG to form PG-AEBSF. PG-AEBSF was then characterized and evaluated for intracellular anti-oxidative stress efficacy (relative to free AEBSF.Results: In the normal rat kidneys, 17 kDa radiolabeled PG (PG-Tr presents a 7-fold higher, while 41 kDa PG-Tr shows a 15-fold higher renal accumulation than the free radiolabel after 24 h post injection. The accumulation of PG-AF was primarily found in the renal tubular

  15. Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015; Budapest (Hungary; September 16-20, 2015; Session “Pharmacology”

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    Various Authors


    Full Text Available Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015; Budapest (Hungary; September 16-20, 2015ORGANIZING INSTITUTIONSEuropean Society for Neonatology (ESN, European Society for Paediatric Research (ESPR, Union of European Neonatal & Perinatal Societies (UENPS, European Foundation for the Care of Newborn Infants (EFCNI, with the local host of Hungarian Society of Perinatology and Obstetric Anesthesiology, Hungarian Society of Perinatology (MPT, supported by Council of International Neonatal Nurses (COINN, organizing secretariat MCA Scientific EventsPROGRAMME COMMITTEEArtúr Beke (Hungarian Society, Morten Breindahl (ESN, Giuseppe Buonocore (UENPS, Pierre Gressens (ESPR, Silke Mader (EFCNI, Manuel Sánchez Luna (UENPS, Miklós Szabó (Hungarian Society of Perinatology, Luc Zimmermann (ESPR Session “Pharmacology”ABS 1. BABY SKIN CARE PRODUCTS • P. Doro, R. Abraham, D. Agoston, J. Balog, R.Z. CsomaABS 2. MATHEMATICAL MODELING TO PREDICT IN-HOSPITAL NATURAL WEIGHT CHANGES IN TERM NEONATES • S. Kasser, M. Wilbaux, C. De Angelis, H. Rickenbacher, N. Klarer, J.N. Van Den Anker, M. Pfister, S. WellmannABS 3. IMPROVING PARENTERAL NUTRITION IN THE NEONATE – A PRACTICAL GUIDELINE • H. Reigstad, D. Moster, I. Grønlie, A. BlystadABS 4. INVOLUTION OF RETINOPATHY OF PREMATURITY AND NEURODEVELOPMENTAL OUTCOME AFTER BEVACIZUMAB TREATMENT • Y.-S. Chang, P.-N. Tsao, C.-Y. Chen, H.-C. Chou, W.-S. Hsieh, P.-T. YehABS 5. RELATIONSHIP BETWEEN ADVERSE DRUG REACTIONS AND OFF-LABEL/UNLICENSED DRUG USE IN HOSPITALISED CHILDREN. EREMI STUDY • K.A. Nguyen, Y. Mimouni, A. Lajoinie, N. Paret, S. Malik, L. El-Amrani, L. Milliat-Guittard, C. Carcel, A. Portefaix, A.M. Schott, T. Vial, B. KassaiABS 6. A SYSTEMATIC REVIEW OF OFF-LABEL AND UNLICENSED DRUGS USE AND ADVERSE DRUG REACTIONS IN HOSPITALIZED CHILDREN • N. David, K.A. Nguyen, Y. Mimouni, A. Lajoinie, S. Malik, B. KassaiABS 7. EFFICACY AND SAFETY OF PROPOFOL SEDATION

  16. Fluid-rock interaction: A reactive transport approach

    Energy Technology Data Exchange (ETDEWEB)

    Steefel, C.; Maher, K.


    irreversible. Helgeson's pioneering approach was given a more formal kinetic basis (including the introduction of real time rather than reaction progress as the independent variable) in subsequent studies (Lasaga 1981; Aagaard and Helgeson 1982; Lasaga 1984). The reaction path approach can be used to describe chemical processes in a batch or closed system (e.g., a laboratory beaker), but such systems are of limited interest in the Earth sciences where the driving force for most reactions is transport. Lichtner (1988) clarified the application of the reaction path models to water-rock interaction involving transport by demonstrating that they could be used to describe pure advective transport through porous media. By adopting a reference frame which followed the fluid packet as it moved through the medium, the reaction progress variable could be thought of as travel time instead. Multi-component reactive transport models that could treat any combination of transport and biogeochemical processes date back to the early 1980s. Berner and his students applied continuum reactive transport models to describe processes taking place during the early diagenesis of marine sediments (Berner 1980). Lichtner (1985) outlined much of the basic theory for a continuum model for multicomponent reactive transport. Yeh and Tripathi (1989) also presented the theoretical and numerical basis for the treatment of reactive contaminant transport. Steefel and Lasaga (1994) presented a reactive flow and transport model for nonisothermal, kinetically-controlled water-rock interaction and fracture sealing in hydrothermal systems based on simultaneous numerical solution of both reaction and transport This chapter begins with a review of the important transport processes that affect or even control fluid-rock interaction. This is followed by a general introduction to the governing equations for reactive transport, which are broadly applicable to both qualitative and quantitative interpretations of fluid

  17. Contributions of GRACE to Climate Monitoring (United States)

    Rodell, Matthew; Famiglietti, James; Chambers, Don P.; Wahr, John


    western Antarctica. For 2002 to present, the rate of ice mass loss has been 200 to 300 GT/yr in Greenland and 70 to 210 GT/yr in Antarctica, and some scientists are suggesting that the rates are accelerating. Similarly, GRACE has been used to monitor mass changes in alpine glaciers. Tamisiea et al. first characterized glacier melt along the southern coast of Alaska, more recently estimated to be occurring at a rate of 84 GT/yr. Chen et al. estimated that Patagonian glaciers are melting at a rate of 28 GT/yr, and estimated that the high mountains of central Asia lose ice at a rate of 47 GT/yr. Tapley et al. and Wahr et al. presented the first GRACE based estimates of changes in column-integrated terrestrial water storage (TWS; the sum of ground-water, soil moisture, surface waters, snow, ice, and water stored in vegetation) at continental scales. Since then, dozens of studies have shown that GRACE based estimates of regional to continental scale TWS variations agree with independent information, and some innovative uses of GRACE data have been developed. Rodell et al. (2004) and Swenson and Wahr (2006) demonstrated that by combining GRACE derived terrestrial water storage changes with observations of precipitation and runoff in a river basin scale water budget, it was possible to produce new estimates of evapotranspiration and atmospheric moisture convergence, essential climate variables that are difficult to estimate accurately. Similarly, GRACE has been used to constrain estimates of global river discharge and the contribution of changes in TWS to sea level rise. Crowley et al. observed a negative correlation between interannual TWS anomalies in the Amazon and the Congo River basin. Yeh et al. and Rodell et al. estimated regionally averaged groundwater storage variations based on GRACE and auxiliary observations. Rodell et al. and Tiwari et al. applied that method to quantify massive groundwater depletion in northern India caused by over reliance on aquifers for irration