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Sample records for kan-su nung yeh

  1. K. C. Yeh: Radio Science Editor

    Science.gov (United States)

    Advances in satellite technology and computer science have had the greatest impact on radio science in the last quarter century, according to Kung Chie Yeh, the new editor of Radio Science. Yeh, whose term began July 1 (Eos, April 12, 1983, p. 137, February 22, 1983, p. 73), is a professor in the electrical engineering department at the University of Illinois at Urbana-Champaign.An international authority on ionospheric radio physics, Yeh also is known for his work on trans-ionospheric radio wave propagation as it affects earth-space communications and satellite navigation. Hehas been studying radio science for nearly 30 years.

  2. Students Learn about Chinese Culture through the Folktale "Yeh-Shen": Emphasizing Figurative Language Interpretation

    Science.gov (United States)

    Palmer, Barbara C.; Sun, Lingzhi; Leclere, Judith T.

    2012-01-01

    This article will analyze the figurative language that reflects Chinese traditional society and culture in "Yeh-Shen." The authors will consider both the figures of speech and the figures of thought (to include symbolism) that provide insight into an understanding of the Chinese culture through a reading of "Yeh-Shen." This analysis can be used by…

  3. YehZYXW of Escherichia coli Is a Low-Affinity, Non-Osmoregulatory Betaine-Specific ABC Transporter.

    Science.gov (United States)

    Lang, Shenhui; Cressatti, Marisa; Mendoza, Kris E; Coumoundouros, Chelsea N; Plater, Samantha M; Culham, Doreen E; Kimber, Matthew S; Wood, Janet M

    2015-09-22

    Transporter-mediated osmolyte accumulation stimulates the growth of Escherichia coli in high-osmolality environments. YehZYXW was predicted to be an osmoregulatory transporter because (1) osmotic and stationary phase induction of yehZYXW is mediated by RpoS, (2) the Yeh proteins are homologous to the components of known osmoregulatory ABC transporters (e.g., ProU of E. coli), and (3) YehZ models based on the structures of periplasmic betaine-binding proteins suggested that YehZ retains key betaine-binding residues. The betaines choline-O-sulfate, glycine betaine, and dimethylsulfoniopropionate bound YehZ and ProX with millimolar and micromolar affinities, respectively, as determined by equilibrium dialysis and isothermal titration calorimetry. The crystal structure of the YehZ apoprotein, determined at 1.5 Å resolution (PDB ID: 4WEP ), confirmed its similarity to other betaine-binding proteins. Small and nonpolar residues in the hinge region of YehZ (e.g., Gly223) pack more closely than the corresponding residues in ProX, stabilizing the apoprotein. Betaines bound YehZ-Gly223Ser an order of magnitude more tightly than YehZ, suggesting that weak substrate binding in YehZ is at least partially due to apo state stabilization. Neither ProX nor YehZ bound proline. Assays based on osmoprotection or proline auxotrophy failed to detect YehZYXW-mediated uptake of proline, betaines, or other osmolytes. However, transport assays revealed low-affinity glycine betaine uptake, mediated by YehZYXW, that was inhibited at high salinity. Thus, YehZYXW is a betaine transporter that shares substrate specificity, but not an osmoregulatory function, with homologues like E. coli ProU. Other work suggests that yehZYXW may be an antivirulence locus whose expression promotes persistent, asymptomatic bacterial infection.

  4. Characterization of the yehUT two-component regulatory system of Salmonella enterica Serovar Typhi and Typhimurium.

    Science.gov (United States)

    Wong, Vanessa K; Pickard, Derek J; Barquist, Lars; Sivaraman, Karthikeyan; Page, Andrew J; Hart, Peter J; Arends, Mark J; Holt, Kathryn E; Kane, Leanne; Mottram, Lynda F; Ellison, Louise; Bautista, Ruben; McGee, Chris J; Kay, Sally J; Wileman, Thomas M; Kenney, Linda J; MacLennan, Calman A; Kingsley, Robert A; Dougan, Gordon

    2013-01-01

    Proteins exhibiting hyper-variable sequences within a bacterial pathogen may be associated with host adaptation. Several lineages of the monophyletic pathogen Salmonella enterica serovar Typhi (S. Typhi) have accumulated non-synonymous mutations in the putative two-component regulatory system yehUT. Consequently we evaluated the function of yehUT in S. Typhi BRD948 and S. Typhimurium ST4/74. Transcriptome analysis identified the cstA gene, encoding a carbon starvation protein as the predominantly yehUT regulated gene in both these serovars. Deletion of yehUT had no detectable effect on the ability of these mutant Salmonella to invade cultured epithelial cells (S. Typhi and S. Typhimurium) or induce colitis in a murine model (S. Typhimurium only). Growth, metabolic and antimicrobial susceptibility tests identified no obvious influences of yehUT on these phenotypes.

  5. 越南岱、侬族纺织图案研究%Study on patterns on textiles of Tay and Nung in Vietnam

    Institute of Scientific and Technical Information of China (English)

    张耀军

    2016-01-01

    Textiles of Tay and Nung nation is one of the most important culture heritages of Vietnam. For the craftsmanship of patterns on textiles of Tay and Nung nation. As for the textile patterns and its craftsmanship of Tay and Nung in China-Vietnam borders, this paper comprehensively analyzed culture and patterns on textiles of Tay and Nung from the perspective of technology, sociology and artistic iconology with the method of field investigation, document research and iconology. The research shows that patterns on textiles created by Tay and Nung embodies their unique history, sense of style and religious believes. These textile patterns thus preserve the traditional culture of these ethnic groups. Field investigations and study on collections from museums give us the evidence for studies on cultural connections between Tay, Nung, Zhuang and those who lives in China-Vietnam border.%岱、侬族纺织图案是越南的重要文化遗产之一,针对中越边境地区岱、侬族的纺织图案及其工艺,采用田野考察、文献研究与图像学方法,从工艺学、社会学及艺术图像学角度,对岱、侬族的纺织图案与文化进行全面分析。研究表明:岱、侬族创造的纺织品图案蕴含了独特的历史、审美及宗教价值,这些图案较好地保存了民族传统文化。通过实地调查和博物馆藏品样式的研究,为中越边境地区壮、岱、侬族之间和其他地区同族之间的文化联系研究提供了证据。

  6. Galaxies with Supermassive Binary Black Holes: (III) The Roche Lobes and Jiang-Yeh Lobe in a Core System

    CERN Document Server

    Yeh, Li-Chin

    2016-01-01

    Three-dimensional equi-potential surfaces of a galactic system with supermassive binary black holes are discussed herein. The conditions of topological transitions for the important surfaces, i.e. Roche Lobes and Jiang-Yeh Lobe, are studied in this paper. In addition, the mathematical properties of the Jacobi surfaces are investigated analytically. Finally, a numerical procedure for determining the regions of the Roche Lobes and Jiang-Yeh Lobe is suggested.

  7. Studi Sistem Pengelolaan PLTS 15 kW Stand Alone Dengan Metode Kano Di Dusun Yeh Mampeh Kabupaten Bangli

    Directory of Open Access Journals (Sweden)

    IGA Andita Putra

    2015-06-01

    Full Text Available Management of PLTS 15 kW stand alone at Yeh mampeh village, bangli regency implemented for PLTS can be utilized optimally and sustainable. Sistem management referring to the results of PLTS component with life time of that and results of the questionnaire. Questionnaire were taken by using Kano Method with 50respondent. Kano categoryused in this study are one dimensional, attractive, must be, indiferent, reverse. This method produces the desired management system of PLTS customers are workers will work twince in one week to four hours every day working with two workers, each employee is given a saary of Rp.300.000, PLTS depreciation is Rp. 3.896.000, with the expected quantity of PLTS customer 150th , so the contribution of each customer every mount is Rp. 28.000. If this sistem can be running by society of Yeh Mampeh Village, then PLTS will be utilized optimally and sustainable.

  8. TEKNIK PENAMPUNGAN DAN FERMENTASI AIR KENCING SAPI BALI DI DESA DAUH YEH CANI, BADUNG MENJADI PUPUK ORGANIK RAMAH LINGKUNGAN

    Directory of Open Access Journals (Sweden)

    IM.S. Negara

    2012-09-01

    Full Text Available ABSTRACT The activity was carried out to put to use of the urine cattle bali with fermented technology. The activity of community servece was ccaried out at Dauh Yeh Cani village, Badung regency, on Suturday, 4 August 2007. The participants from the farmers group at Dauh Yeh Cani village. The demo plots was carried out at KUBE KMM. The material of a demo plots i.e. a removal by product (urine with feces and than its were fermented.. The products made from the activity were liquied fertilizer organic (clean governunt. The participants were curious to follow all the activities and hope for the team Unud be able to came again with a news information.

  9. Failure Study of Composite Materials by the Yeh-Stratton Criterion

    Science.gov (United States)

    Yeh, Hsien-Yang; Richards, W. Lance

    1997-01-01

    The newly developed Yeh-Stratton (Y-S) Strength Criterion was used to study the failure of composite materials with central holes and normal cracks. To evaluate the interaction parameters for the Y-S failure theory, it is necessary to perform several biaxial loading tests. However, it is indisputable that the inhomogeneous and anisotropic nature of composite materials have made their own contribution to the complication of the biaxial testing problem. To avoid the difficulties of performing many biaxial tests and still consider the effects of the interaction term in the Y-S Criterion, a simple modification of the Y-S Criterion was developed. The preliminary predictions by the modified Y-S Criterion were relatively conservative compared to the testing data. Thus, the modified Y-S Criterion could be used as a design tool. To further understand the composite failure problem, an investigation of the damage zone in front of the crack tip coupled with the Y-S Criterion is imperative.

  10. Traditional Marriage Customs of The Zhuang Ethnic in China and Nung,Tay Ethnics in Vietnam%中国壮族和越南侬族、岱族的传统婚姻习俗

    Institute of Scientific and Technical Information of China (English)

    覃丽芳

    2014-01-01

    The Zhuang ethnic in China and Nung, Tay ethnics in Vietnam have the same root, many similar or the same in language, culture, etc. Some cultural elements in traditional marriage customs in Zhuang, Nung, Tay ethnics prove that they have the same root, and that’s the natural link to keep friendly exchanges between the border ethnic in China and Vietnam.%中国的壮族和越南的侬族、岱族是同源民族,在语言、文化等方面有许多相同或相似的地方。壮、侬、岱族传统婚姻习俗中一些共有的文化元素体现了这几个民族之间的同源性,也是中越边境民族友好交往的天然纽带。

  11. A Comparison Between Guangxi Zhuang Language and Vietnamese Nung Language%越南高平侬语和广西靖西壮语的初步比较

    Institute of Scientific and Technical Information of China (English)

    彭茹

    2014-01-01

    广西靖西县新靖镇壮语和越南高平省茶岭县广汉村侬语的语言结构特点比较接近,在跨境语言中属于差异较小的类型。二者跨境后之所以还能保持如此高的相似度与跨境历史不长有关,还与两国边民相似的文化、习俗及密切的经济往来有关。%The structural characteristics of Zhuang language in Xinjing , a town of Jingxi County in Guan-gxi, and Nung language in Guanghan , a village in Chanling county of Gaoping province in Vietnam , are quite simi-lar and have fewer differences compared with other cross -border languages .The great similarity they share are re-lated not only to the fact that they have a short cross -border history but also to the likeness of their cultures and traditions as well as the close economic exchanges between them .

  12. Die Bankenunion als Krönung der Wirtschafts- und Währungsunion?

    OpenAIRE

    2015-01-01

    This article analyses the positions of Germany, France and the EU institutions with regard to the negotiations on two of the most important elements agreed: the Single Supervisory Mechanism (SSM) and the Single Resolution Mechanism (SRM). This article highlights the different approaches and lines of conflict on the centralisation of competences, legal basis, and, in case of the SRM, the sources of funding.

  13. The variation of the ground electric field associated with the Mei-Nung earthquake on Feb. 6, 2016

    Science.gov (United States)

    Bing-Chih Chen, Alfred; Yeh, Er-Chun; Chuang, Chia-Wen

    2017-04-01

    Recent studies show that a strong coupling exists between lithosphere, atmosphere and extending up to the ionosphere. Natural phenomena on the ground surface such as oceans variation, volcanic and seismic activities such as earthquakes, and lightning possibly generate significant impacts at ionosphere immediately by electrodynamic processes. The electric field near the ground is one of the potential quantities to explore this coupling process, especially caused by earthquake. Unfortunately, thunderstorm, dust storm or human activities also affect the measured electric field at ground. To investigate the feasibility of a network to monitor the variation of the ground electric field driven by the lightning and earthquake, a filed mill has been deployed in the NCKU campus since Dec. 2015, and luckily experienced the earthquake with a moment magnitude of 6.4 struck 28 km on 6 Feb. 2016. The recorded ground electric field deceased steadily since 1.5 days before the earthquake, and returned to normal level gradually. Moreover, this special feature can not be identified in the other period of the field test. The detail analysis is reported in this presentation.

  14. IDENTIFIKASI SUMBER PENCEMAR DAN ANALISIS KUALITAS AIR TUKAD YEH SUNGI DI KABUPATEN TABANAN DENGAN METODE INDEKS PENCEMARAN

    Directory of Open Access Journals (Sweden)

    Ni Made Setiari

    2015-06-01

    Full Text Available Based on the data of Environmental Status of Bali Province Year 2009, Sungi River is the one of ten rivers that have experience quality degradation which contaminated by waste. Pollution parameters that have exc.eeded the quality standard, are: BOD, COD, Total Phosphate, Total Coliform, and Faecal Coliform. It requires to concerned because Sungi River as the point area for drinking water in Tabanan (data of Environmental Board of Bali Province. Purpose of research is to determine the characteristic of pollution source which will be impact to the changing of water quality in physical, chemical, and biological in middle and down stream area, detern1ine the pollution index in up stream, middle. and dow stream area of Sungi River. Water parameters that will observe are: temperature, pH, turbidity, TDS, TSS, DHL, DO, BOD, COD, Total Phosphate, Total Coliform and Faecal Coliform. The measurement result will compare with the best of water quality, based on the Regulation of Bali Governor Number 8 Year 2007, because of it utilization as drinking water. Result of research shown that the activity in Sungi River dominated by agriculture activity, settlement, animal husbandry, and industry that located in dov.n stream area. The waste that result from the above activities caused the degradation of water quality that shown by the increasing of water parameter indicators, such as: BOD, COD, Total Phosphate, and Faecal Coliform Bacteria. In the middle will increasing and down stream area will get degradation. This condition is inversely proportional to the content of DO as impact of contaminants accumulation, such as: organic waste in middle are, because the water movement is more calm with average water flow is 0,14 m/second compared with the up and down stream area with average water flow are 0,15 m/second and 0,35 m/second. Characteristic of pollution source which effect the water quality at Sungi River in area I caused by llie activities of agriculture, animal husbandry, settlement, and industry, for area II caused by the activities of agriculture, animal husbandry, settlement, and villa. The quality staLus of Sungi Rlver in up stream area still result a good quality water but in the middle and down stream area are get lightly pollution. Water quality parameter which exceeded a good water quality in Sw1gi Rive,· is Total Phosphate with average value is 0,44 mg/I in the middle area, 0,40 mg/l in down stream area and Faecal Coliform with average value is 166/100 ml in the middle area and 152/100 ml in the down stream area.

  15. ANALISIS STATUS LINGKUNGAN IRIGASI TUKAD YEH EMPAS DAN SUBAK MUNDUK LENGGUNG DI DUSUN BOLANGAN DESA BABAHAN KECAMATAN PENEBEL KABUPATEN TABANAN

    Directory of Open Access Journals (Sweden)

    I NYOMAN SUMANTRA

    2015-06-01

    Full Text Available Livestock is one business that was developed in order to meet basic human needs of the flesh. In its development, livestock will produce waste harmful to the environment. The purpose of this study to determine the characteristics and environmental management of farms, the quality and quantity of waste and its impact on the environment and to know the public perception and labor to the impact of livestock on the environment, economy and social life of communities around the farm and ranch labor. Characteristics and environmental management by the entrepreneur obtained by distributing questionnaires livestock determination of the sample by random sampling, samples for the determination of the quality and quantity of livestock waste with purposive sampling. Samples were taken at three points of different sewage farms and compared with the Minister of State for the Environment No. 11 of 2009 and four points on the body of water and then compared with the Bali gubernatorial No.8 of 2007. Samples were analyzed in situ and laboratory. To know the public perception and labor obtained by distributing questionnaires determination of samples with random sampling. Environmental management by the entrepreneur is less cattle. quality of wastewater from hog farms shows the parameters of TSS (1082.57 mg / 1. quantity of wastewater from pig farms outlet (Qo2 0.004 m3/dt, TSS pollutant load on a pig farm (4330.68 mg / dt. Parameter that exceeds the quality standard on water bodies (TSS, BOD5, COD. Public perception and labor to the impact of farm businesses is positive (good.

  16. 77 FR 28880 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2012-05-16

    ..., Inglewood, CA 90301, Officers: Edison Chen, Manager (Qualifying Individual), Wei-Nung (Janus) Lin, Member... A. Case, Vice President (Qualifying Individual), Thomas C. Case, President, Application Type:...

  17. The history of ginseng in the management of erectile dysfunction in ancient China (3500-2600 BCE).

    Science.gov (United States)

    Nair, Rajesh; Sellaturay, Senthy; Sriprasad, Seshadri

    2012-01-01

    Emperor Shen-Nung was the second of China's mythical emperors (3500-2600 BCE). Widely considered the father of Chinese medicine, he catalogued over 365 species of medicinal plants which he personally tasted. Through his treatise 'Shen Nung Benchau Jing', we relive Emperor Shen-Nung's contribution to urology with reference to his management of erectile dysfunction. Time-related sources in medical and historical literature were reviewed, including the 'Shen Nung Benchau Jing' (The medicine book of Emperor Shen-Nung), archives and manuscripts at the Wellcome History of Medicine Collection, the Royal Society of Medicine, London, The Hong Kong Museum of Medical Sciences, and The Museum of Medical History, Shanghai, China. Chinese traditional herbal medicine began approximately 5000 years ago. Agricultural clan leader, Emperor Shen-Nung, was said to have a 'crystal-like belly' to watch the reactions in his own stomach of the herbs he collected. Ginseng was among of Shen Nung's contributions to herbal medicine. He experienced a warm and sexually pleasurable feeling after chewing the root. He advocated this as a treatment for erectile dysfunction and used it to stimulate sexual appetite. The reputation of ginseng as an aphrodisiac is based on the doctrine of signatures, since the adult root has a phallic shape. Shen-Nung believed that ginseng's resemblance to the human form is proof of its rejuvenative and aphrodisiac properties. It was believed that the closer the similarity to the human figure, the more potent the root. The use of ginseng for erectile dysfunction by Emperor Shen-Nung was unique for its time. It continues to hold parallels as a modern-day herbal aphrodisiac 5000 years on.

  18. The history of ginseng in the management of erectile dysfunction in ancient China (3500-2600 BCE

    Directory of Open Access Journals (Sweden)

    Rajesh Nair

    2012-01-01

    Full Text Available Emperor Shen-Nung was the second of China′s mythical emperors (3500-2600 BCE. Widely considered the father of Chinese medicine, he catalogued over 365 species of medicinal plants which he personally tasted. Through his treatise ′Shen Nung Benchau Jing′, we relive Emperor Shen-Nung′s contribution to urology with reference to his management of erectile dysfunction. Time-related sources in medical and historical literature were reviewed, including the ′Shen Nung Benchau Jing′ (The medicine book of Emperor Shen-Nung, archives and manuscripts at the Wellcome History of Medicine Collection, the Royal Society of Medicine, London, The Hong Kong Museum of Medical Sciences, and The Museum of Medical History, Shanghai, China. Chinese traditional herbal medicine began approximately 5000 years ago. Agricultural clan leader, Emperor Shen-Nung, was said to have a ′crystal-like belly′ to watch the reactions in his own stomach of the herbs he collected. Ginseng was among of Shen Nung′s contributions to herbal medicine. He experienced a warm and sexually pleasurable feeling after chewing the root. He advocated this as a treatment for erectile dysfunction and used it to stimulate sexual appetite. The reputation of ginseng as an aphrodisiac is based on the doctrine of signatures, since the adult root has a phallic shape. Shen-Nung believed that ginseng′s resemblance to the human form is proof of its rejuvenative and aphrodisiac properties. It was believed that the closer the similarity to the human figure, the more potent the root. The use of ginseng for erectile dysfunction by Emperor Shen-Nung was unique for its time. It continues to hold parallels as a modern-day herbal aphrodisiac 5000 years on.

  19. A Novel Hand-Held Optical Imager with Real-Time Co-Registration Facilities Towards Diagnostic Mammography

    Science.gov (United States)

    2012-01-01

    spectroscopy,” UCI Undergraduate Res. J. II, pp. 43–49, 1999. [11] B. J. Tromberg, N. Shah, R. Lanning, A. Cerussi, J. Espinoza , T. Pham, L. Svaasand, and J...mammography,” Acad. Ra- diol., vol. 8, pp. 211–218, 2001. [14] N. Shah, A. Cerussi, C. Eker, J. Espinoza , J. Butler, J. Fishkin, R. Hor- nung, and B

  20. Der französische GAV ist unrealistisch

    CERN Multimedia

    1984-01-01

    "Seit über zwei Wochen ist bei Genf ein Arbeitskonflikt im Gang. Die Arbeiter, die für das CERN eine gigantische Forschungsanlage bauen sollen, verlangen eine bessere Entlönung. Doch das federfürende Baukonsortium will nicht darauf eingehen, und die CERN-Verantwortlichen halten sich aus der Sache raus" (1 page).

  1. A Software Pipeline for Protein Structure Prediction

    Science.gov (United States)

    2006-11-01

    Department of Cell Biology and Biochemistry U. S. Army Medical Research Institute of Infectious Diseases Frederick, MD 21702 In-Chul Yeh, Nela ...Suite for Protein Structure Prediction Michael S. Lee U. S. Army Research Laboratory In-Chul Yeh, Nela Zavaljevski, Paul Wilson, and Jaques Reifman

  2. Stereoselectivity and substrate specificity in the kinetic resolution of methyl-substituted 1-oxaspiro[2.5]octanes by Rhodotorula glutinis epoxide hydrolase

    NARCIS (Netherlands)

    Weijers, C.A.G.M.; Meeuwse, P.; Herpers, R.L.J.M.; Franssen, M.C.R.; Sudhölter, E.J.R.

    2005-01-01

    [GRAPHICS] The kinetic resolution of a range of methyl-substituted 1-oxaspiro[2.5]octanes by yeast epoxide hydrolase (YEH) from Rhodotorula glutinis has been investigated. The structural determinants of substrate specificity and stereoselectivity of YEH toward these substrates appeared to be the con

  3. DMPD: LPS/TLR4 signal transduction pathway. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 18304834 LPS/TLR4 signal transduction pathway. Lu YC, Yeh WC, Ohashi PS. Cytokine. ...2008 May;42(2):145-51. Epub 2008 Mar 4. (.png) (.svg) (.html) (.csml) Show LPS/TLR4 signal transduction path...way. PubmedID 18304834 Title LPS/TLR4 signal transduction pathway. Authors Lu YC, Yeh WC, Ohashi PS. Publica

  4. Towards a Formalism for Program Generation 1992 - Final Report

    Science.gov (United States)

    1992-12-01

    Contributors: Raymond Yeh, Peter Ng, Luqi, Joseph Urban, Ron Norman, W.D. Hurley, John Baker, Patrick Bobbie, WT Tsai, Greg Boone, Nick Bourbakis , etc. In...Ltd. Contributors: Raymond Yeh, Peter Ng, Luqi, Joseph Urban, Ron Norman, W.D. Hurley, John Baker, Patrick Bobbie, WT Tsai, Greg Boone, Nick Bourbakis

  5. A unifying framework for the problem of adjudicating conflicting claims

    DEFF Research Database (Denmark)

    Hougaard, Jens Leth; Østerdal, Lars Peter Raahave; Moreno-Terero, Juan D.

    2012-01-01

    In a recent paper, Thomson and Yeh [Thomson, W., Yeh, C.-H., 2008. Operators for the adjudication of conflicting claims. Journal of Economic Theory 143, 177–198] introduced the concept of operators on the space of rules for the problem of adjudicating conflicting claims. They focused on three ope...

  6. Local Ionospheric Scintillation Analysis

    Science.gov (United States)

    2017-03-14

    WORK UNIT NUMBER 7.  PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) ASIAN INSTITUTE OF TECHNOLOGY MOO 9 PHAHOLYOTHIN RD KM.42 KLONG NUNG PATHUM 12120...carried out as part of the densification and maintenance of the SCINDA network in South East Asia. 15.  SUBJECT TERMS Ionosphere, AOARD 16...Theoretical Physics (ICTP), International Civil Aviation Organization (ICAO), Boston College, University of California Los Angeles and AMBER projects

  7. What You Need to Know about Drugs (For Kids)

    Science.gov (United States)

    ... see into the future. Inhalant (say: in-HAY-lent) — An inhalant, such as glue or gasoline, is ... and is very addictive. Stimulant (say: STIM-yeh-lent) — A stimulant speeds up the body and brain. ...

  8. Hormonal Resistance and Metastasis: ER-coregulator-Src Targeted Therapy

    Science.gov (United States)

    2009-09-01

    1. Dimple Chakravarty, Sujit Nair, Binoj Chandrasekhar Nair, Long Wang , Abhik Bandyopadhyay, Joseph K. Agyin, Frank Lee, Lu- Zhe Sun, I-Tien Yeh...Poster Board Number: 11 Author Block: Dimple Chakravarty, Sujit Nair, Binoj Chandrasekhar Nair, Long Wang , Abhik Bandyopadhyay, Joseph K. Agyin, Frank...Lee, Lu- Zhe Sun, I-Tien Yeh, Rajeshwar Rao Tekmal, Ratna K. Vadlamudi. UT Health Science Ctr., San Antonio, TX, Bristol-Myers Squibb Pharmaceutical

  9. Electroactive Polyurea Bearing Oligoaniline Pendants: Electrochromic and Anticorrosive Properties

    Science.gov (United States)

    2014-12-26

    1,3- phenylenedioxy)dianiline were purchased from Aldrich. Ferric chloride, ammonium persulfate (APS), potassium carbonate , so- dium chloride...acetone, diethyl ether and ethanol were purchased from commercial sources and used as received without further purification. Optically transparent Indium...2007;52:5191e200. [59] Chang CH, Huang TC, Peng CW, Yeh TC, Lu HI, Hung WI, et al. Carbon 2012;50: 5044e51. [60] Wei Y, Wang J, Jia X, Yeh JM, Spellane

  10. Conserved ABC Transport System Regulated by the General Stress Response Pathways of Alpha- and Gammaproteobacteria

    Energy Technology Data Exchange (ETDEWEB)

    Herrou, Julien; Willett, Jonathan W.; Czyz, Daniel M.; Babnigg, Gyorgy; Kim, Youngchang; Crosson, Sean

    2017-03-01

    Brucella abortus sigma(E1) is an EcfG family sigma factor that regulates the transcription of dozens of genes in response to diverse stress conditions and is required for maintenance of chronic infection in a mouse model. A putative ATP-binding cassette transporter operon, bab1_0223-bab1_0226, is among the most highly activated gene sets in the sigma(E1) regulon. The proteins encoded by the operon resemble quaternary ammonium-compatible solute importers but are most similar in sequence to the broadly conserved YehZYXW system, which remains largely uncharacterized. Transcription of yehZYXW is activated by the general stress sigma factor sigma(S) in Enterobacteriaceae, which suggests a functional role for this transport system in bacterial stress response across the classes Alphaproteobacteria and Gammaproteobacteria. We present evidence that B. abortus YehZYXW does not function as an importer of known compatible solutes under physiological conditions and does not contribute to the virulence defect of a sigma(E1)- null strain. The sole in vitro phenotype associated with genetic disruption of this putative transport system is reduced growth in the presence of high Li+ ion concentrations. A crystal structure of B. abortus YehZ revealed a class II periplasmic binding protein fold with significant structural homology to Archaeoglobus fulgidus ProX, which binds glycine betaine. However, the structure of the YehZ ligand-binding pocket is incompatible with high-affinity binding to glycine betaine. This is consistent with weak measured binding of YehZ to glycine betaine and related compatible solutes. We conclude that YehZYXW is a conserved, stress-regulated transport system that is phylogenetically and functionally distinct from quaternary ammonium-compatible solute importers

  11. Investigating Ductal Carcinoma in Situ Using Noninvasive Imaging of Genetically Engineered Mouse Models

    Science.gov (United States)

    2013-08-01

    LaMarca H, Edwards D, Kerbawy S, Heestand JC, Young E, Mukhopadhyay P, Yeh HW, Allred DC, Hu M, Polyak K, Rosen JM, Medina D. An intraductal human...2010 134-8. Behbod F, Kittrell F S, Lamarca H, Edwards D, Kerbawy S, Heestand J C, Young E, Mukhopadhyay P, Yeh H W, Allred D C, Hu M, Polyak K, Rosen...Bauerlein E L, Hahn W C, Gelman R S, Allred C, Bissell M J, Schnitt S and Polyak K 2008 Regulation of in situ to invasive breast carcinoma

  12. Conserved ABC Transport System Regulated by the General Stress Response Pathways of Alpha- and Gammaproteobacteria

    Energy Technology Data Exchange (ETDEWEB)

    Herrou, Julien; Willett, Jonathan W.; Czyż, Daniel M.; Babnigg, Gyorgy; Kim, Youngchang; Crosson, Sean; Stock, Ann M.

    2016-12-19

    ABSTRACT

    Brucella abortusσE1is an EcfG family sigma factor that regulates the transcription of dozens of genes in response to diverse stress conditions and is required for maintenance of chronic infection in a mouse model. A putative ATP-binding cassette transporter operon,bab1_0223-bab1_0226, is among the most highly activated gene sets in the σE1regulon. The proteins encoded by the operon resemble quaternary ammonium-compatible solute importers but are most similar in sequence to the broadly conserved YehZYXW system, which remains largely uncharacterized. Transcription ofyehZYXWis activated by the general stress sigma factor σSinEnterobacteriaceae, which suggests a functional role for this transport system in bacterial stress response across the classesAlphaproteobacteriaandGammaproteobacteria. We present evidence thatB. abortusYehZYXW does not function as an importer of known compatible solutes under physiological conditions and does not contribute to the virulence defect of a σE1-null strain. The solein vitrophenotype associated with genetic disruption of this putative transport system is reduced growth in the presence of high Li+ion concentrations. A crystal structure ofB. abortusYehZ revealed a class II periplasmic binding protein fold with significant structural homology toArchaeoglobus fulgidusProX, which binds glycine betaine. However, the structure

  13. Control of Venous Thromboembolism and Metastasis in Breast Cancer by Antifibrinolysis Mechanism

    Science.gov (United States)

    2009-09-01

    WJ. Molecular cloning of fibroblast activation protein alpha, a member of the serine protease family selectively expressed in stromal fibroblasts of...Sánchez ML, Salamone M, Yeh YY, Flessate D, Chen W- T. Molecular cloning of seprase: A serine integral membrane protease from human melanoma, Biochimica et

  14. The Fourteenth International Meeting on Time-Resolved Vibrational Spectroscopy (TRVS XIV)

    Science.gov (United States)

    2010-02-03

    617-253-7030 e-mail: tokmakof@MIT.edu Project Manager: Dr. Michael Berman Grant Number: FA9550-09-1-0473 March 2, 2010...Hoffmann, Janos Hebling, Harold Y. Hwang, THz-pump/THz-probe nonlinear spectroscopy Ka-Lo Yeh, Keith A. Nelson, MIT 11:30 AM C Tomonori Nomoto and

  15. EXCEDE Energy Deposition. Theory and Experiment Compared.

    Science.gov (United States)

    1980-11-30

    pillse at an altitude of 123 ki. Sec onda ri 1Y, i t involved a comparison with preliminary photographic data recorded from 1te ground on a s imi lar...Supervisor for K. Yeh BDM Corp ATTN: T. Neighbors Institute for Defense Analyses ATTN: L. Jacobs ATTN: J. Bengston ATTN: J. Aein Berkeley Research

  16. Mental Health Help-Seeking Behaviors among Asian American Community College Students: The Effect of Stigma, Cultural Barriers, and Acculturation

    Science.gov (United States)

    Han, Meekyung; Pong, Helen

    2015-01-01

    According to the 2008 U.S. Census, there are 15.5 million Asian Americans in the United States, and 17% are students enrolled in a university (Shea & Yeh, 2008). Asian American college students in higher education are oftentimes perceived as the "model minority" with high academic achievements and few mental and/or behavioral…

  17. Publication of Papers Presented at URSI 23RD General Assembly as a Special Section of Radio Science

    Science.gov (United States)

    1992-05-15

    Mainardi [1989] to a dissipative medium. In quite similar ways the first and second spatial moments of According to the superposition principle, a wave a...Yeh, Wave Propagation Laboratory, Van Groesen, E., and F. Mainardi , Energy propagation in Department of Electrical and Computer Engineering

  18. Attention Effects on Form Discrimination at Different Eccentricities

    Science.gov (United States)

    1989-01-01

    Eriksen & Hoffman, 1974; Eriksen & St. James, 1986; Eriksen & Yeh, 1985; Holtzman, Sidtis, Volpe, Wilson, & Gazzaniga , 1981; Jonides, 1980, 1983...cross-classified categorical data (2nd ed.). Cambridge, MA: M.I.T. Press. 30 Holtzman, J. D., Sidtis, J. J., Volpe, B. T., Wilson, D. H., & Gazzaniga

  19. Mathematics, Programming, and STEM

    Science.gov (United States)

    Yeh, Andy; Chandra, Vinesh

    2015-01-01

    Learning mathematics is a complex and dynamic process. In this paper, the authors adopt a semiotic framework (Yeh & Nason, 2004) and highlight programming as one of the main aspects of the semiosis or meaning-making for the learning of mathematics. During a 10- week teaching experiment, mathematical meaning-making was enriched when primary…

  20. CAS academician honored at 4th world urban forum

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    @@ Prof. Anthony Yeh, a CAS Member from the University of Hong Kong (HKU), is selected the winner of the 2008 UN-HABITAT Lecture Award--the highest international acclaims in the town planning field. The award is to recognize outstanding and sustained contributions to research, thinking and practice in human settlements development and planning. Prof.

  1. Dynamics of Explosions in Fuel-Air Mixtures.

    Science.gov (United States)

    1977-01-01

    Seattle, July 11-14, 1977. :5. "Detection of Acoustic Waves with a PI-DMOS Transducer," (K. W. Yeh, R. S. luller, and S. H. Kwan) japanese Journal of Applied Physics , Vol. 16, Supplement 16-1, pp. 517-521, 1977.

  2. Age, Emotion Regulation Strategies, Temperament, Creative Drama, and Preschoolers' Creativity

    Science.gov (United States)

    Yeh, Yu-Chu; Li, Me-Lin

    2008-01-01

    Based on Yeh's (2004) "Ecological Systems Model of Creativity Development", this study investigated the effects that age, the use of emotion regulation strategies, temperament, and exposure to creative drama instruction have on the development of creativity among preschool children. Participants were 116 4- to 6-year-old preschool children. This…

  3. On the onset of nano-ordered phase distributions in high-entropy alloys

    NARCIS (Netherlands)

    Rao, J. C.; Ocelík, V.; Vainchtein, D.; Tang, Z.; Liaw, P. K.; De Hosson, J. Th M.

    2017-01-01

    This contribution to the Festschrift concentrates on 'nano-s', a topic which is central in Ilya Ovid'ko scientific work in the field of materials physics. In particular, we concentrate on a rather new alloying design concept of so-called High-Entropy Alloys (HEA) that was proposed by Yeh et al. in

  4. Tsai et al., Afr J Tradit Complement Altern Med. (2014) 11(2):343 ...

    African Journals Online (AJOL)

    cadewumi

    Shiang-Jiun Tsai1*, Ying-Xu Ruan2*, Ching-Chih Lee3,6, Moon-Sing Lee1,6, ..... Tsai, H.L., Chen, C.W., Yeh, Y.S., Ma, C.J., Huang, C.J., and Wang, J.Y. (2012). .... Cancer Patients' Attitudes Towards Chinese Medicine: A Hong Kong Survey.

  5. Regulatory link between steryl ester formation and hydrolysis in the yeast Saccharomyces cerevisiae.

    Science.gov (United States)

    Ploier, Birgit; Korber, Martina; Schmidt, Claudia; Koch, Barbara; Leitner, Erich; Daum, Günther

    2015-07-01

    Steryl esters and triacylglycerols are the major storage lipids of the yeast Saccharomyces cerevisiae. Steryl esters are formed in the endoplasmic reticulum by the two acyl-CoA:sterol acyltransferases Are1p and Are2p, whereas steryl ester hydrolysis is catalyzed by the three steryl ester hydrolases Yeh1p, Yeh2p and Tgl1p. To shed light on the regulatory link between steryl ester formation and hydrolysis in the maintenance of cellular sterol and free fatty acid levels we employed yeast mutants which lacked the enzymes catalyzing the degradation of steryl esters. These studies revealed feedback regulation of steryl ester formation by steryl ester hydrolysis although in a Δtgl1Δyehyeh2 triple mutant the gene expression levels of ARE1 and ARE2 as well as protein levels and stability of Are1p and Are2p were not altered. Nevertheless, the capacity of the triple mutant to synthesize steryl esters was significantly reduced as shown by in vitro and in vivo labeling of lipids with [(14)C]oleic acid and [(14)C]acetate. Enzymatic analysis revealed that inhibition of steryl ester formation occurred at the enzyme level. As the amounts and the formation of sterols and fatty acids were also decreased in the triple mutant we concluded that defects in steryl ester hydrolysis also caused feedback inhibition on the formation of sterols and fatty acids which serve as precursors for steryl ester formation. In summary, this study demonstrates a regulatory link within the steryl ester metabolic network which contributes to non-polar lipid homeostasis in yeast cells.

  6. Proceedings of Neurotox 󈨜, Molecular Basis of Drug and Pesticide Action (3rd) Held in Bath, England on April 10-15, 1988

    Science.gov (United States)

    1988-06-01

    Irving , S. and Olsen, R.W. (1985) Locust ganglia contain [ 3H]flunitrazepam binding sites. Biochem. Soc. Trans. 13, 716-717. 15 Robinson, T.M., MacAllan...channel inactiva- tion: separate sites for the action of grayanotoxin and tetramethrin. Brain Res. in press. 44 Kirsch , G.E., Yeh, J.Z., Farley, J.M...target receptors is specific and can occur at very low concentrations of ligand. Irving [13], for example. observed pyrethroid induced miniature

  7. Laser Covariance Vibrometry for Unsymmetrical Mode Detection

    Science.gov (United States)

    2006-09-01

    machine failure (currently termed “health monitoring ”). Changes in motor or journal bearings PSD’s 11Spectral elimination / reduction (phase averaging) is...ENY, Wright Patterson AFB OH 45433 – 7321, Dec 2004. AFITDSENY04-9. 91. Yariv, Amnon and Poci Yeh. Optical Waves in Crystals, Propagation and Control...WORK UNIT NUMBER 6. AUTHOR(S) 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING / MONITORING

  8. Trees as Filters of Radioactive Fallout from the Chernobyl Accident

    CERN Document Server

    Brownridge, James D

    2011-01-01

    This paper is a copy of an unpublished study of the filtering effect of red maple trees (acer rubrum) on fission product fallout near Binghamton, NY, USA following the 1986 Chernobyl accident. The conclusions of this work may offer some insight into what is happening in the forests exposed to fallout from the Fukushima Daiichi Nuclear Plant accident. This posting is in memory of Noel K. Yeh.

  9. Analysis of Investigational Drugs in Biological Fluids - Method Development and Routine Assay

    Science.gov (United States)

    1994-08-14

    by parasites , including tropical or subtropical zones with drug-resistant forms, the U.S. Army needs to organize programs so that highly active and...has developed resistance towards a number of insecticides widely used for vector control. But, the more alarming reason is that the malarial parasite ...qinghaosu). Planta Med. 1985, 5, 445-6. 47 Brossi A; Venugopalan B; Dominguez Gerpe L; Yeh HIj; Flippen- Anderson JL; Buchs P; Luo XD; Milhous W

  10. DDJC-Sharpe Defense Distribution Depot: FEMWATER 3D Transport Model of TCE Plume Migration with Natural Attenuation

    Science.gov (United States)

    2004-03-01

    the Paducah Gaseous Diffusion Plant , Paducah , Kentucky. Jacobs Environmental Management, Kevil, KY. Lin, H. J., Richards, D. R., Yeh, J., Cheng J...a. Molecular diffusion of TCE, (3.87e - 05 ft2/hr), was practically negligible, but was included for completeness (Jacobs EM Team (1998)). b...Barbara.P.Donnell@erdc.usace.army.mil). REFERENCES Cussler, E. L. (1997). Diffusion – Mass transfer in fluid systems. 2nd ed., Cambridge University Press, 580 pp

  11. Managing Workload in Human-Robot Interaction: A Review of Empirical Studies

    Science.gov (United States)

    2010-01-01

    systems, have the highest possible frame rate and augment the system with cues to another sensory modality (e.g., hearing, tactile ). If speed is...distance in virtual environments. Presence, 7(2), 144–167. *Yeh, M., & Wickens, C. D. (2001). Display signaling in augmented reality : Effects of cue...a bit, the results on FOV are mixed , but do suggest higher levels of performance with wide to moderate FOV over one more narrow. A potential downside

  12. Investigations of Magnetosphere-Ionosphere Coupling Relevant to Operational Systems.

    Science.gov (United States)

    1988-02-01

    time and magnetic activity has been insestigated over to work with, many workers make the assumption of a steady the Nears (among others, Starkov and...Gussenhoven, M. S., D. A. Hardy, F. Rich, V. J. Burke, and H.-C. Yeh. Starkov , G. V., and Y. I. Feldstein, Variations of auroral o\\,al zone bound- High-level... Starkov , and Y. 1. Feldstein, Influences of the inter- IReceised August 4, 1986; planetary magnetic field on the auroral dynamics. Planet. Space Sc

  13. The Sino-Soviet Rivalry and Chinese Security Debate.

    Science.gov (United States)

    1982-10-01

    Victories," Hongqi, No. 15, 16 August 1981, in FBIS- China, 17 September 1981, pp. K10-K23. Sterba , James P., "China’s Army Follows New Marching Orders...provocative and original. Discussions with Rand colleagues Paul Langer, Norman Levin, James Thomson, and K. C. Yeh have also proved very helpful in shap- ing...Parks, 1980; Butterfield, 1980b; Butterfield, 1981; Sterba , 1981. 33 has also been unhappy about the severe downgrading of Mao Zedong’s historical

  14. Diffusion Tensor Imaging and Its Application to Traumatic Brain Injury: Basic Principles and Recent Advances

    Science.gov (United States)

    2012-12-01

    USA 4Center for Neuroscience and Regenerative Medicine, Uniformed Services University of the Health Sciences, Bethesda, USA Email: *pinghongyeh...ORGANIZATION NAME(S) AND ADDRESS(ES) Uniformed Services University of the Health Sciences,Center for Neuroscience and Regenerative Medicine,Bethesda,MD...unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 P.-H. YEH ET AL. 138 Sports-related TBI, particularly in football and

  15. Plasma Synthesis and Sintering of Advanced Ceramics

    Science.gov (United States)

    1990-09-15

    glow discharge, corona discharge, RF or microwave discharge, etc.) and the electron concentration in the plasma are important. The efficiency of... corona discharge, and the low pressure capacitively or inductively coupled RF discharge. It is probable that a low pressure microwave discharge would also...Rhodes, "Agglomerate and Particle Size Effects on Sintering Yttria- Stabilized Zirconia ", J. Am. Ceram. Soc., 64 [1] 19-22 (1981). 4. T. S. Yeh and M

  16. Radon-222 in the lunar atmosphere.

    Science.gov (United States)

    Brodzinski, R. L.

    1972-01-01

    In 1969 Yeh and Van Allen set upper limits for the alpha-particle emissivity of the moon. The equilibrium surface activity reported by Turkevich et al. (1970) for each alpha active Rn-222 daughter at Mare Tranquillitatis cannot be reconciled with existing diffusion theory. The data, therefore, suggest that earth based diffusion constants are not applicable in the vacuum conditions of the moon, or that there are substantial variations in the uranium content of the moon over relatively small distances.

  17. Quasi-Analytic Model of OTHR Clutter from Equatorial Bubbles in the Ionosphere

    Science.gov (United States)

    2006-02-27

    raytrace code developed to study OTH radar clutter is based on the theory provided by Hazelgrove [1954], Yeh and Liu [1972], Jones and Stephenson [1975... radar (OTHR) sky wave becomes Doppler shifted because the ionosphere through which the radio rays are propagating changes. One source of these changes...trace computations to yield predictions for Doppler shifts in the unstable ionosphere. 15. SUBJECT TERMS Over-the-horizon radar Computer model of the

  18. Efficient Methods of Estimating the Operating Characteristics of Item Response Categories and Challenge to a New Model for the Multiple-Choice Item

    Science.gov (United States)

    1981-11-01

    directions of future research. This final report has been completed with the dedicated assistantship by Paul S. Changas, Charles MeCarter, Shiao-Yung Chen...others, Paul S. Changas, C. I. Bonnie Chen, Philip S. Livingston, Charles T. McCarter, Melanie Perkins, Robert L. Trestman and I Ching-Chan Yeh have... Lazarsfeld ( Lazarsfeld , 1959) and others as a theory of social attitude measurement in the area of sociology, and also by the work accomplished by Rasch

  19. The use of Optical Magnetic Twisting Cytometry and Flourescence Resonance Energy Transfer to quantify force-induced protein dissociation in the nucleus of a living cell

    OpenAIRE

    sprotocols

    2015-01-01

    Authors: Yeh-Chuin Poh & Ning Wang ### Abstract Mechanical forces are known to play a significant role in biological processes. These forces can be transmitted to the cell through the cytoskeletal filament network, inducing different biochemical responses within the cytoplasm. Although there have been ample reports showing that cytoplasmic enzymes can be directly activated by a local stress on the cell surface via integrins, there has been no evidence that mechanical forces can di...

  20. The Lessons of East Asian Development and Alternative Development Strategies for Hainan

    Science.gov (United States)

    1991-01-01

    34 in Y. L. Wu and K. C. Yeh (eds.), Growth, Distribution, and Social Change: Essays on The Economy of The Republic of China , Occasional Papers, School...was supported by a grant from the National Research Center for Science and Technology for Development, People’s Republic of China . The RAND...Technology for Development, People’s Republic of China Accesion IFor NTIS CR.,-&! OTtC lA*ý •I, Justi ficjtion By

  1. Security Enhanced User Authentication Protocol for Wireless Sensor Networks Using Elliptic Curves Cryptography

    Directory of Open Access Journals (Sweden)

    Younsung Choi

    2014-06-01

    Full Text Available Wireless sensor networks (WSNs consist of sensors, gateways and users. Sensors are widely distributed to monitor various conditions, such as temperature, sound, speed and pressure but they have limited computational ability and energy. To reduce the resource use of sensors and enhance the security of WSNs, various user authentication protocols have been proposed. In 2011, Yeh et al. first proposed a user authentication protocol based on elliptic curve cryptography (ECC for WSNs. However, it turned out that Yeh et al.’s protocol does not provide mutual authentication, perfect forward secrecy, and key agreement between the user and sensor. Later in 2013, Shi et al. proposed a new user authentication protocol that improves both security and efficiency of Yeh et al.’s protocol. However, Shi et al.’s improvement introduces other security weaknesses. In this paper, we show that Shi et al.’s improved protocol is vulnerable to session key attack, stolen smart card attack, and sensor energy exhausting attack. In addition, we propose a new, security-enhanced user authentication protocol using ECC for WSNs.

  2. Security enhanced user authentication protocol for wireless sensor networks using elliptic curves cryptography.

    Science.gov (United States)

    Choi, Younsung; Lee, Donghoon; Kim, Jiye; Jung, Jaewook; Nam, Junghyun; Won, Dongho

    2014-06-10

    Wireless sensor networks (WSNs) consist of sensors, gateways and users. Sensors are widely distributed to monitor various conditions, such as temperature, sound, speed and pressure but they have limited computational ability and energy. To reduce the resource use of sensors and enhance the security of WSNs, various user authentication protocols have been proposed. In 2011, Yeh et al. first proposed a user authentication protocol based on elliptic curve cryptography (ECC) for WSNs. However, it turned out that Yeh et al.'s protocol does not provide mutual authentication, perfect forward secrecy, and key agreement between the user and sensor. Later in 2013, Shi et al. proposed a new user authentication protocol that improves both security and efficiency of Yeh et al.'s protocol. However, Shi et al.'s improvement introduces other security weaknesses. In this paper, we show that Shi et al.'s improved protocol is vulnerable to session key attack, stolen smart card attack, and sensor energy exhausting attack. In addition, we propose a new, security-enhanced user authentication protocol using ECC for WSNs.

  3. Green tea in dermatology--myths and facts.

    Science.gov (United States)

    Zink, Alexander; Traidl-Hoffmann, Claudia

    2015-08-01

    Green tea consumption has a long tradition in Asian countries--especially China. The epidemiologically and experimentally observed anticarcinogenic and antiinflammatory effects of green tea have led to the implementation of green tea extracts in multiple therapeutic applications - both in dermatological and cosmeceutical preparations. The most abundant evidence exists for the anticarcinogenic and chemopreventive effect of green tea or its major constituent epigallocatechin-3-gallate. Almost equally evident is the effect in infectious diseases such as cutaneous viral infections. For external genital warts, a topical ointment with green tea extracts was licensed in the USA in 2010, and recently also in Europe. Experimental evidence pinpointing the block of central signal transduction factors in inflammatory mechanisms has led to the evaluation of catechins in inflammatory disorders such as atopic dermatitis. The belief of green tea as a "wonder weapon" against diseases dates back thousands of years. According to a Chinese legend, ancient Emperor Shen Nung noted a delightful aroma after some leaves of a nearby tree had fallen into boiling water. He immediately proclaimed the new "drink" as "heaven-sent", starting the belief - persisting until today - of green tea as a medication from nature against many different diseases. This review summarizes biological effects and clinical implications of green tea.

  4. Endocannabinoid immune and vascular signaling

    Institute of Scientific and Technical Information of China (English)

    George B STEFANO

    2000-01-01

    @@HISTORY Hemp has been cultivated for 7000 to 8000 years〔1〕. The Sumerian/Babylonian term for cannabis hemp is K (a)N(a)B(a), and it is one of the longest surviving root words in Indo-Semitic-European language. In 2700 BC, Shen Nung, a contributor to early Chinese medicine, mentions cannabis in the pharmacopoeia. Around 500 BC Zoroaster, a Persian prophet, in the Zend-Avesta, listing 10 000 medicinal plants, includes hemp. In the first century AD the Chinese begin making paper from hemp as an inexpensive means of preserving information. In 800 AD the Islamic prophet Mohammed allows cannabis use. In 1100, Moslems use cannabis to start Europe's first paper mill. In 1430 Saint Joan D'Arc is accused of using herbal drags, ie, cannabis, to hear voices. Pope Innocent VIII (1484) labels cannabis as an unholy sacrament of the Satanic mass and issues a ban on cannabis. Queen Elizabeth I (1563) and King Phillip of Spain (1564) order land owners to grow cannabis. In America, the Jamestown Colony, Virginia (1619), enacts the New World's first marijuana legislation, ordering all farmers to grow Indian hemp seed.

  5. Virtual reality simulation for the optimization of endovascular procedures: current perspectives

    Directory of Open Access Journals (Sweden)

    Rudarakanchana N

    2015-03-01

    Full Text Available Nung Rudarakanchana,1 Isabelle Van Herzeele,2 Liesbeth Desender,2 Nicholas JW Cheshire1 1Department of Surgery, Imperial College London, London, UK; 2Department of Thoracic and Vascular Surgery, Ghent University Hospital, Ghent, BelgiumOn behalf of EVEREST (European Virtual reality Endovascular RESearch TeamAbstract: Endovascular technologies are rapidly evolving, often requiring coordination and cooperation between clinicians and technicians from diverse specialties. These multidisciplinary interactions lead to challenges that are reflected in the high rate of errors occurring during endovascular procedures. Endovascular virtual reality (VR simulation has evolved from simple benchtop devices to full physic simulators with advanced haptics and dynamic imaging and physiological controls. The latest developments in this field include the use of fully immersive simulated hybrid angiosuites to train whole endovascular teams in crisis resource management and novel technologies that enable practitioners to build VR simulations based on patient-specific anatomy. As our understanding of the skills, both technical and nontechnical, required for optimal endovascular performance improves, the requisite tools for objective assessment of these skills are being developed and will further enable the use of VR simulation in the training and assessment of endovascular interventionalists and their entire teams. Simulation training that allows deliberate practice without danger to patients may be key to bridging the gap between new endovascular technology and improved patient outcomes.Keywords: virtual reality, simulation, endovascular, aneurysm

  6. A Unifying Framework for the Problem of Adjudicating Conflicting Claims

    DEFF Research Database (Denmark)

    Hougaard, Jens Leth; Moreno-Ternero, Juan D.; Østerdal, Lars Peter Raahave

    the structure of such a space. In this paper, we generalize their analysis upon presenting and studying a general family of operators inspired by three apparently unrelated approaches to the problem of adjudicating conflicting claims. We study the structural properties of this family and show, in particular......In a recent paper, Thomson and Yeh [Operators for the adjudication of conflicting claims, Journal of Economic Theory 143 (2008) 177-198] introduced the concept of operators on the space of rules for the problem of adjudicating conflicting claims. They focussed on three operators in order to uncover...

  7. The Mesosphere and Thermosphere,

    Science.gov (United States)

    1981-01-01

    and Joule heating (Q = J.E) and has been studied by many authors (see e.g. [40] and references therein). Testud [41] found that the efficiency of...K/day, respectively. Testud and Vasseur [611 observed a T.I.D. following a magnetic storm and noted that the ion temperature at the 300 km level rose... Testud [62] and Yeh [30] have estimated that heating rates of the order of 10 - 0 watts/m 3 (10 - 9 ergs/cm 3 sec) occur at F-region heights due

  8. 営口の巨商東盛和の倒産

    OpenAIRE

    倉橋正直

    1981-01-01

    In November 6, 1907, the Tung-shêng-hê store, based in Newchwang, an important trade port in the Northeast of China, managed by Yeh Liang-ch’ing 薬売卿 went bankrupt. This store was engaged in several kinds of business: wholesaling, finance, oil-milling, marine-transportation, tobacco processing, real estate, etc. The Tung-shêng-hê was one of the leading stores in Newchwang with trade bases in Tientsin, Shanghai, and Canton. This case of insolvency had far reaching effects and caused economic pa...

  9. Handbook of fiber optics theory and applications

    CERN Document Server

    Yeh, Chai

    2013-01-01

    Dr. Yeh supplies a firm theoretical foundation in such topics as propagation of light through fibers, fiber fabrication, loss mechanisms, and dispersion properties. He then expands from this into such practical areas as fiber splicing, measuring loss in fibers, fiber-based communications networks, remote fiber sensors, and integrated optics. Whether involved in fiber optics research, design, or practical implementation of systems, this handbook will be extremely useful.Key Features* Here is a comprehensive, ""one-stop"" reference with state-of-the-art information on fiber optics Included is da

  10. A Unifying Framework for the Problem of Adjudicating Conflicting Claims

    DEFF Research Database (Denmark)

    Hougaard, Jens Leth; Moreno-Ternero, Juan D.; Østerdal, Lars Peter Raahave

    In a recent paper, Thomson and Yeh [Operators for the adjudication of conflicting claims, Journal of Economic Theory 143 (2008) 177-198] introduced the concept of operators on the space of rules for the problem of adjudicating conflicting claims. They focussed on three operators in order to uncover...... the structure of such a space. In this paper, we generalize their analysis upon presenting and studying a general family of operators inspired by three apparently unrelated approaches to the problem of adjudicating conflicting claims. We study the structural properties of this family and show, in particular...

  11. Electron Transporting Semiconductor Dielectric Intramolecular

    Science.gov (United States)

    2012-04-27

    self-organized n-channel OSCs. The first polyimide, a class of polymers generally considered an insulator before this work, was made.( Kola ...Amine Sensing via Synergistic Responses by n and p Organic Semiconductors” Adv. Funct. Mat. 21, 4314-4319 (2011) Kola , S.; Sinha, J.; Katz, H.E...23054 (2012) Kola , S.; Tremblay, N.J.; Yeh, M.-L.; Katz, H.E.; Kirschner, S.B.; Reich, D.H. “Synthesis and Characterization of a Pyromellitic Diimide

  12. Description of Sarasaeschna kaoi sp. nov. in Taiwan, with notes on the proposed differentiating characters of the pyanan-group (Odonata, Aeshnidae).

    Science.gov (United States)

    Yeh, Wen-Chi; Lee, I-Lung; Wong, Kwok-Ching

    2015-03-04

    Sarasaeschna kaoi sp. nov. collected from Yuli, Hualien County in eastern Taiwan, is easily distinguished from all known congeners by its male having short and straight cerci. Judging from male penile structure, it is considered to belong to the pyanan-group of species and resembles in general appearance the Chinese S. zhuae described from Fujian. The only known habitat of S. kaoi is a muddy and grassy swamp in natural evergreen forest. The diagnostic characters of the pyanan-group proposed by Karube & Yeh are also discussed.

  13. Transient Effects in Turbulence Modelling.

    Science.gov (United States)

    1979-12-01

    p. 22. 20. Ibid., pp. 106-121. 21. Yeh, Y., H. Cummins, "Localized Fluid Flow Measurement with a He-Ne Laser Spectrometer ," Appl. Phys. Letters, 4...74 NIuttu ~ ~~ D.Ot’ U xw1 wwwwww ww OOOwwOOwwQOQ M1 (h~O~ O Ch OOw nqr n N OOM **\\I 11 Or1 NN.-eu. i ico I I IIIO N 1 O Nl *^I bWWWWW .r’--.WcooI

  14. Collisions Between Britain And Ottoman Empire In Iraq Front During the World War I (1915)

    OpenAIRE

    Sakin, Serdar

    2010-01-01

    Soon after the outbreak of the World War I, 12th and 13th Army Corps as a power were settled in the Iraq front because a British campaign was not expected in this front. By the beginning of the war, British powers captured Basra in Iraq. However, these powers easily had a rapid advance from South to North because of the weakness of Ottoman Powers. Britain captured this region after defeating Ottoman Powers at the battles of Kurna, Shaibe, Amara, Nasırıyeh and Kut Al Amara. The main reason of ...

  15. Acute parietal lobe infarction presenting as Gerstmann’s syndrome and cognitive decline mimicking senile dementia

    OpenAIRE

    Chen TY; Chen CY; Yen CH; Kuo SC; Yeh YW; Chang S; Huang SY

    2013-01-01

    Tien-Yu Chen,1 Chun-Yen Chen,1,3 Che-Hung Yen,2,3 Shin-Chang Kuo,1,3 Yi-Wei Yeh,1,3 Serena Chang,1 San-Yuan Huang1,31Department of Psychiatry, 2Department of Neurology, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, 3Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan, Republic of ChinaAbstract: Gerstmann’s syndrome encompasses the tetrad of finger agnosia, agraphia, acalculia, and right-left confusion. An elder...

  16. CANNABIS MEDICINAL

    Directory of Open Access Journals (Sweden)

    Alfredo Jácome Roca

    2014-12-01

    Full Text Available Los estupefacientes han estado presentes en la historia de la medicina desde la antigüedad. La materia médica china (Pen-ts’ao-Ching atribuida al emperador rojo Shen-nung, incluye a la Cannabis indica para reducir el dolor del reumatismo y por sus beneficios en desórdenes digestivos. El láudano (tintura alcohólica de opio, la esponja anestésica (mandrágora con opio, o la teriaca (polifármaco que contenía opio fueron pilar de la lucha contra el dolor y otros males. El opio proviene del jugo de la corteza verde de la adormidera –variedad de amapola- o Papaver somniferum y ha sido reemplazado como potente analgésico de acción central por su alcaloide morfina o por análogos como la meperidina (1. Desde sus orígenes, el ser humano ha buscado alivio en diversas plantas medicinales, la analgesia, la sedación pero también la euforia. El efecto pasajero y la taquifilaxia generada por el uso continuo impulsan un aumento en la frecuencia y en la cantidad de las dosis, perdiéndose sus beneficios y aumentando su toxicidad. En estos casos, disminuye el número y la sensibilidad de los diferentes receptores, fenómeno conocido como down-regulation. Al ser adictivos, el manejo de estos narcóticos debe ser estrictamente médico y fuertemente regulado, cosa de la que se han librado el alcohol y el tabaco. La prohibición del licor solo llevó al enriquecimiento de los contrabandistas. Hay alucinógenos menos villanos como los obtenidos de la Cannabis sativa, aunque no son demasiado benignos.

  17. Magneto-optical parameters of Co 90Fe 10 and Co 50Fe 50 ferromagnetic thin films for 1.3 μm integrated isolator

    Science.gov (United States)

    Lesuffleur, A.; Vanwolleghem, M.; Gogol, P.; Bartenlian, B.; Beauvillain, P.; Harmle, J.; Lagae, L.; Pistora, J.; Postava, K.; Visnovsky, S.; Wirix-Speetjens, R.

    2006-10-01

    In order to optimize a 1.3 μm integrated optical isolator using a CoFe alloy for the non-reciprocal magneto-optical (MO) transverse Kerr effect, we have measured the optical and magneto-optical indices of Co 90Fe 10 and Co 50Fe 50 alloys grown in the Al 2O 3/Al/CoFe/GaAs multilayer structure. The optical reflectivity and MO rotation and ellipticity measurements were performed at variable incidence angle and s and p polarization of the incident light. In order to determine the optical and MO indices, the experimental data were fitted using a Matlab implementation of a standard multilayer Yeh formalism including multiple reflections. This original procedure allows precise determination of the optical and MO indices of CoFe alloys.

  18. Tracing erosion patterns in Taiwan by quantitative provenance and geomorphological analysis

    Science.gov (United States)

    Resentini, Alberto; Goren, Liran; Castelltort, Sebastien; Garzanti, Eduardo

    2016-04-01

    Taiwan is one of the world's foremost natural laboratories for studies of orogenesis. After only a few Ma of ongoing collision between the Chinese continental margin and the Luzon Arc, the associated orogen has reached nearly 4 km in height and 100-150 km in width. High rates of convergence leading to rapid rock uplift combine with the wet stormy climate of the sub-tropical typhoon belt to deliver annually an average detrital mass of 9500 t/km2. The doubly-vergent thrust belt is composed of more than 85% of sedimentary rocks dominant in the pro-wedge, but metamorphic rocks as young as Journal of Geophysical Research: Earth Surface 119:1853-1875. Willett S.D., Fisher D., Fuller C., Yeh E.C., Lu C.Y. 2003. Erosion rates and orogenic-wedge kinematics in Taiwan inferred from fission-track thermochronometry. Geology 31:945-948.

  19. POSTERS

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    @@Natural Toxins   S01 Susceptibility of Edible Bihalves to Paralytic Shellfish Poisons and Their Donor   Ya-Hui Li* , Deng-Fwu Hwang, Jou-Fang Deng, Taibei, China      S02 Food Safety of Grass Carp Bile Juice   Deng-Fwu Hwang* , Yen-Hung Yeh, Jou-Feng Deng, Taibei, China      S03 Differentiation of Muscular Proteins from Toxic and Non Toxic Puffers   Tai-Yuan Chen* , Deng-Fwu Hwang, Taibei, China      S04 Radiation Resistance of Paralytic Shellfish Poison (PSP) Toxins   Terestia P Acevedo, Philippines

  20. Computation of the pseudoskin factor for a restricted-entry well

    Energy Technology Data Exchange (ETDEWEB)

    Ding, W. (Joshi Technologies International Inc., Tulsa, OK (United States)); Reynolds, A.C. Jr. (Univ. of Tulsa, OK (United States))

    1994-03-01

    Wells frequently are completed over a fraction of the oil zone to delay water and gas coning. This type of completion is called a restricted-entry or partially penetrating well. When analyzing well-test data from a restricted-entry well, semilog analysis of pseudoradial flow data yields an estimate of the total skin factor, which is a linear combination of the mechanical skin factor and the pseudoskin factor caused by restricted entry. This work presented two new equations for computing the pseudoskin factor from a restricted-entry well completed in a multilayer reservoir. These equations represent generalization of formulas presented by Papatzacos and Vrbik for single-layer homogeneous reservoirs. For ranges of reservoir and well parameters ordinarily encountered, the new equations provide results approximately equal to those obtained from the Yeh-Reynolds calculation procedure, but are easier to use than this equation.

  1. Determination of permeability distribution from well-test pressure data

    Energy Technology Data Exchange (ETDEWEB)

    Feitosa, G.S.; Chu, L.; Thompson, L.G.; Reynolds, A.C. (Univ. of Tulsa, OK (United States))

    1994-07-01

    The emergence of reservoir characterization has stimulated efforts to obtain improved information on reservoir heterogeneities. This work considers single-phase flow to a well in a reservoir where permeability varies with distance from the well. The authors consider methods for estimating the permeability distribution from well-test pressure data. The methods considered were obtained by modifying and extending elegant seminal works of Oliver and Yeh and Agarwal. This work considers the analysis of pressure data, both drawdown and buildup, obtained at a well producing reservoir in which the absolute permeability varies with position. A new inverse-solution algorithm is presented that can be applied to estimate the reservoir permeability distribution as a function of distance from the well.

  2. 沙发和椅子 疯狂设计创意

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    <正>在许多年前,椅子就成为生活中必不可少的家具,到了如今它展现了更为个性的古灵精怪的表情,让你的生活也多了不少情趣。伦敦设计师Kenyon Yeh:UNIKEA系列家具设计伦敦的设计师Kenyon Yeh设计了一套特别的家具叫做UNIKEA(UniqueIKEA)系列。Kenyon说道:这个系列家具试图通过差异化的形式去塑造个性。使用一套标准的宜家配件,然后随意组装,不用按照

  3. Interpretation of transmission through type II superconducting thin film on dielectric substrate as observed by laser thermal spectroscopy

    Science.gov (United States)

    Šindler, M.; Tesař, R.; Koláček, J.; Skrbek, L.

    2012-12-01

    We provide a thorough analysis of THz properties of BCS-like superconducting thin films. Temperature and frequency dependence of complex conductivity in zero magnetic field is discussed by utilizing the Zimmerman et al. explicit BCS based formula [Physica C 183 (1991) 99]. We extend this approach by employing the effective medium theory and develop a phenomenological model capable of accounting for the influence of external magnetic field. Using Yeh powerful formalism [Surface Sci. 96 (1980) 41] we calculate optical transmission of linearly polarized laser beam normally incident to a multilayered sample consisting of a thin NbN film grown on birefringent sapphire substrate, entirely covering ranges of interest in temperature and frequency. A proposal to exploit linear polarization of the incident beam parallel with principal axes of conductivity tensor is explained and theoretical predictions for a realistic NbN sample are computed and discussed.

  4. Review Essay: Knowing Society, Cultivating Citizens, and Making the State in Post-Imperial China

    Directory of Open Access Journals (Sweden)

    Robert Culp

    2013-03-01

    Full Text Available Tong Lam. A Passion for Facts: Social Surveys and the Construction of the Chinese Nation-State, 1900–1949. Berkeley: University of California Press, 2011. 280 pp. $60 (cloth.Janet Y. Chen. Guilty of Indigence: The Urban Poor in China, 1900–1953. Princeton: Princeton University Press, 2012. 320 pp. $45 (cloth/eBook.Understanding society and building the national community were, in many ways, paired common goals for China’s intellectuals and political leaders during the first half of the twentieth century. Complementary new books by Tong Lam and Janet Chen illuminate key dynamics of those processes. Lam’s A Passion for Facts: Social Surveys and the Construction of the Chinese Nation-State, 1900–1949 tracks the development of the social survey movement (shehui diaocha yundong during the first half of the twentieth century. Chen’s Guilty of Indigence: The Urban Poor in China, 1900–1953 analyzes efforts to explain poverty, categorize the poor, and extend to the needy “active relief,” which was meant to transform them from “parasites” into productive citizens. Together the books demonstrate how new systems of knowledge served to map the social field and how institutions of governance defined and reshaped social groups for the project of national mobilization, with Lam concentrating more on the development of modern technologies of knowledge and Chen focusing more on the development of governmental institutions and the imposition of social discipline. Through their analyses these books help to explain the process whereby abstract academic fields and research methodologies, along with theories and techniques of social governance, had material effects that transformed millions of people’s daily lives. They provide, in other words, striking examples of what Wen-hsin Yeh, Eddy U, and I have elsewhere characterized as “organized knowledge in action” (Culp, U, and Yeh n.d....

  5. Morphodynamics structures induced by variations of the channel width

    Science.gov (United States)

    Duro, Gonzalo; Crosato, Alessandra; Tassi, Pablo

    2014-05-01

    In alluvial channels, forcing effects, such as a longitudinally varying width, can induce the formation of steady bars (Olesen, 1984). The type of bars that form, such as alternate, central or multiple, will mainly depend on the local flow width-to-depth ratio and on upstream conditions (Struiksma et al., 1985). The effects on bar formation of varying the channel width received attention only recently and investigations, based on flume experiments and mathematical modelling, are mostly restricted to small longitudinal sinusoidal variations of the channel width (e.g. Repetto et al., 2002; Wu and Yeh, 2005, Zolezzi et al., 2012; Frascati and Lanzoni, 2013). In this work, we analyze the variations in equilibrium bed topography in a longitudinal width-varying channel with characteristic scales of the Waal River (The Netherlands) using two different 2D depth-averaged morphodynamic models, one based on the Delft3D code and one on Telemac-Mascaret system. In particular, we explore the effects of changing the wavelength of sinusoidal width variations in a straight channel, focusing on the effects of the spatial lag between bar formation and forcing that is observed in numerical models and laboratory experiments (e.g. Crosato et al, 2011). We extend the investigations to finite width variations in which longitudinal changes of the width-to-depth ratio are such that they may affect the type of bars that become unstable (alternate, central or multiple bars). Numerical results are qualitatively validated with field observations and the resulting morphodynamic pattern is compared with the physics-based predictor of river bar modes by Crosato and Mosselman (2009). The numerical models are finally used to analyse the experimental conditions of Wu and Yeh (2005). The study should be seen as merely exploratory. The aim is to investigate possible approaches for future research aiming at assessing the effects of artificial river widening and narrowing to control bar formation in

  6. PTEN insufficiency modulates ER+ breast cancer cell cycle progression and increases cell growth in vitro and in vivo

    Directory of Open Access Journals (Sweden)

    Chiang KC

    2015-08-01

    Full Text Available Kun-Chun Chiang,1,4 Huang-Yang Chen,1 Shu-Yuan Hsu,2 Jong-Hwei S Pang,3 Shang-Yu Wang,4 Jun-Te Hsu,4 Ta-Sen Yeh,4 Li-Wei Chen,5 Sheng-Fong Kuo,6 Chi-Chin Sun,7 Jim-Ming Lee,1 Chun-Nan Yeh,4 Horng-Heng Juang21Department of General Surgery, Chang Gung Memorial Hospital, Chang Gung University, Keelung, 2Department of Anatomy, 3Graduate Institute of Clinical Medical Sciences, 4Department of General Surgery, 5Department of Gastroenterology, 6Department of Endocrinology and Metabolism, 7Department of Ophthalmology, Chang Gung Memorial Hospital, Chang Gung University, Keelung, Taiwan, Republic of China Abstract: Phosphatase and tensin homolog (PTEN, a well-known tumor suppressor gene and frequently mutated or lost in breast cancer, possesses the negative regulation function over the PI3K/Akt/mTOR pathway. PTEN insufficiency has been associated with advanced breast cancer and poor prognosis of breast cancer patients. Recently, target therapies aimed at PI3K/Akt/mTOR pathway to treat breast cancer have got popularity. However, the exact effect of PTEN on breast cancer cells is still not well understood. This study demonstrated that PTEN knockdown in MCF-7 cells strengthened the downstream gene expressions, including p-Akt, p-ERK1/2, p-mTOR, p-p70s6k, and p-GSK3ß. PTEN knockdown MCF-7 cells had increased cell growth and Ki-67 expression. Further Western blot demonstrated that p27 was repressed obviously with p21 slightly inhibited and CDK1, 2, 4, 6, cyclin A, and Cdc25C were upregulated in MCF-7 PTEN knockdown cells, leading to the higher growth rate. More importantly, PTEN knockdown MCF-7 cells had higher tumorigenesis and tumor growth in vivo. From our current work, we provided more detailed PTEN-mediated mechanisms to stimulate ER+ breast cancer cell growth. Our result may pave the way for further target therapy development used alone or in combination with other drugs for ER+ breast cancer with PTEN insufficiency.Keywords: PTEN, breast cancer, MCF-7

  7. Object-Based Attention Guided by An Invisible Object

    Directory of Open Access Journals (Sweden)

    Xilin Zhang

    2011-05-01

    Full Text Available Many studies have demonstrated that attention can be object based. One line of evidence supporting object-based attention showed that observers respond to a target faster when the target and cue are in the same object than when they are in different objects, which is called the same-object advantage. By adopting the double-rectangle cuing paradigm (Egly, Driver, & Rafal, 1994, we tested whether this advantage can occur with invisible rectangles. The original paradigm was slightly modified. Rectangles had a low luminance level against a dark background and were presented for only 10 ms, along with a cue or a target. These two characteristics rendered the rectangles invisible to subjects, as confirmed by a forced-choice test. We found a conventional object-based attention effect even when the rectangles were invisible. We also found that the object-based attention was dependent on the orientation of the rectangles presented along with the target, consistent with the finding by Ho and Yeh (2009. These results suggest that object based attention can be guided by an invisible object in an automatic way, with a minimal influence from the high level top-down control.

  8. Understanding community beliefs of Chinese-Australians about cancer: initial insights using an ethnographic approach.

    Science.gov (United States)

    Yeo, Soo See; Meiser, Bettina; Barlow-Stewart, Kristine; Goldstein, David; Tucker, Katherine; Eisenbruch, Maurice

    2005-03-01

    Ethnography was employed to investigate the hypothesis that the cultural meaning of cancer is one of the possible barriers to access of cancer services. The objectives were to identify indigenous terminologies, taxonomies and illness explanatory models of cancer in a community-based sample of 15 Chinese-Australians and a sample of 16 informants who had been recruited through two Sydney familial cancer clinics. Many of the informants included in their narrative terms that seemed to match Western biomedical explanations for cancer. The majority of informants also maintained traditional Chinese beliefs, despite high acculturation and beliefs in biomedical explanations about cancer. Explanations of illness including cancer, referred to the following concepts: (i) karma (yeh), (ii) retribution (bao ying), (iii) fate (ming yun) or Heaven's or God's will, (iv) geomancy (feng-shui), (v) touched evil (zhong chia), (vi) misfortune or bad luck (shui wan, dong hark); (vii) offending the gods or deities requiring prayers or offerings for appeasement; and (viii) kong-tau (spells invoked through human intervention). Taking into consideration the heterogeneity of the Chinese population, the findings provide an insight into Chinese illness conceptualization that may assist health professionals to develop an understanding of how the cultural explanatory models affect access to screening services, communication of diagnosis of cancer and management of treatment regimen. Copyright 2004 John Wiley & Sons, Ltd.

  9. Integrated Modeling of Groundwater and Surface Water Interactions in a Manmade Wetland

    Directory of Open Access Journals (Sweden)

    Guobiao Huang Gour-Tsyh Yeh

    2012-01-01

    Full Text Available A manmade pilot wetland in south Florida, the Everglades Nutrient Removal (ENR project, was modeled with a physics-based integrated approach using WASH123D (Yeh et al. 2006. Storm water is routed into the treatment wetland for phosphorus removal by plant and sediment uptake. It overlies a highly permeable surficial groundwater aquifer. Strong surface water and groundwater interactions are a key component of the hydrologic processes. The site has extensive field measurement and monitoring tools that provide point scale and distributed data on surface water levels, groundwater levels, and the physical range of hydraulic parameters and hydrologic fluxes. Previous hydrologic and hydrodynamic modeling studies have treated seepage losses empirically by some simple regression equations and, only surface water flows are modeled in detail. Several years of operational data are available and were used in model historical matching and validation. The validity of a diffusion wave approximation for two-dimensional overland flow (in the region with very flat topography was also tested. The uniqueness of this modeling study is notable for (1 the point scale and distributed comparison of model results with observed data; (2 model parameters based on available field test data; and (3 water flows in the study area include two-dimensional overland flow, hydraulic structures/levees, three-dimensional subsurface flow and one-dimensional canal flow and their interactions. This study demonstrates the need and the utility of a physics-based modeling approach for strong surface water and groundwater interactions.

  10. Social Networks and the Maintenance of Conformity: Japanese sojourner women.

    Science.gov (United States)

    Saint Arnault, Denise; Roles, Deborah J

    2012-08-01

    Asian immigrant women have the lowest utilization of mental health services of any ethnic minority (Garland, Lau, Yeh & McCabe 2005). Because help seeking for distress occurs within social networks, we examined how social networks supported or disabled help seeking for Japanese sojourners living in the US. Unfortunately, most of the literature about Japanese social relationships focuses on men in organizational settings. This study used intensive ethnographic interviewing with 49 Japanese expatriate women to examine how social relationships influenced psychosocial distress and help seeking. We found that the women in these samples engaged in complex, highly regulated, complicated and obligatory relationships through their primary affiliation with other "company wives." Like many immigrant women, increased traditional cultural norms (referred to in Japanese as ryoosai kenbo, or good wives and wise mothers), were expected from these modern women, and the enactment of these roles was enforced through scrutiny, gossip and the possibility of ostracism. Fears of scrutiny was described by the women as a primary barrier to their self-disclosure and ultimate help seeking. Understanding the social organization and support within the Japanese women's community is central to understanding how culturally specific social networks can both give support, as well as create social constraints to help seeking. Health oriented prevention programs must consider these social factors when evaluating the immigration stressors faced by these families.

  11. Model analysis of temperature dependence of abnormal resistivity of a multiwalled carbon nanotube interconnection

    Directory of Open Access Journals (Sweden)

    Yi-Chen Yeh

    2010-07-01

    Full Text Available Yi-Chen Yeh1, Lun-Wei Chang2, Hsin-Yuan Miao3, Szu-Po Chen1, Jhu-Tzang Lue11Department of Physics and 2Institute of Electronics Engineering, National Tsing Hua University, Hsinchu, Taiwan; 3Department of Electrical Engineering, Tunghai University, Taichung, TaiwanAbstract: A homemade microwave plasma-enhanced chemical vapor deposition method was used to grow a multiwalled carbon nanotube between two nickel catalyst electrodes. To investigate the transport properties and electron scattering mechanism of this interconnection (of approximately fixed length and fixed diameter, we carried out a model analysis of temperature dependence of resistivity. To explain the abnormal behavior of the negative temperature coefficient of resistivity in our experimental results, we then employed theories, such as hopping conductivity theory and variable range hopping conductivity theory, to describe resistivity in the high- and low-temperature ranges, respectively. Further, the grain boundary scattering model is also provided to fit the entire measured curve of temperature dependence of resistivity.Keywords: multiwalled carbon nanotube, resistivity, hopping conductivity, temperature dependence

  12. System-size corrections for self-diffusion coefficients calculated from molecular dynamics simulations: The case of CO2, n-alkanes, and poly(ethylene glycol) dimethyl ethers

    Science.gov (United States)

    Moultos, Othonas A.; Zhang, Yong; Tsimpanogiannis, Ioannis N.; Economou, Ioannis G.; Maginn, Edward J.

    2016-08-01

    Molecular dynamics simulations were carried out to study the self-diffusion coefficients of CO2, methane, propane, n-hexane, n-hexadecane, and various poly(ethylene glycol) dimethyl ethers (glymes in short, CH3O-(CH2CH2O)n-CH3 with n = 1, 2, 3, and 4, labeled as G1, G2, G3, and G4, respectively) at different conditions. Various system sizes were examined. The widely used Yeh and Hummer [J. Phys. Chem. B 108, 15873 (2004)] correction for the prediction of diffusion coefficient at the thermodynamic limit was applied and shown to be accurate in all cases compared to extrapolated values at infinite system size. The magnitude of correction, in all cases examined, is significant, with the smallest systems examined giving for some cases a self-diffusion coefficient approximately 15% lower than the infinite system-size extrapolated value. The results suggest that finite size corrections to computed self-diffusivities must be used in order to obtain accurate results.

  13. Reaction-Based Reactive Transport Modeling of Iron Reduction and Uranium Immobilization at Area 2 of the NABIR Field Research Center

    Energy Technology Data Exchange (ETDEWEB)

    Burgos, W.D.

    2009-09-02

    This report summarizes research conducted in conjunction with a project entitled “Reaction-Based Reactive Transport Modeling of Iron Reduction and Uranium Immobilization at Area 2 of the NABIR Field Research Center”, which was funded through the Integrative Studies Element of the former NABIR Program (now the Environmental Remediation Sciences Program) within the Office of Biological and Environmental Research. Dr. William Burgos (The Pennsylvania State University) was the overall PI/PD for the project, which included Brian Dempsey (Penn State), Gour-Tsyh (George) Yeh (Central Florida University), and Eric Roden (formerly at The University of Alabama, now at the University of Wisconsin) as separately-funded co-PIs. The project focused on development of a mechanistic understanding and quantitative models of coupled Fe(III)/U(VI) reduction in FRC Area 2 sediments. The work builds on our previous studies of microbial Fe(III) and U(VI) reduction, and was directly aligned with the Scheibe et al. ORNL FRC Field Project at Area 2.

  14. Practical Implementation of New Particle Tracking Method to the Real Field of Groundwater Flow and Transport.

    Science.gov (United States)

    Suk, Heejun

    2012-01-01

    In articles published in 2009 and 2010, Suk and Yeh reported the development of an accurate and efficient particle tracking algorithm for simulating a path line under complicated unsteady flow conditions, using a range of elements within finite elements in multidimensions. Here two examples, an aquifer storage and recovery (ASR) example and a landfill leachate migration example, are examined to enhance the practical implementation of the proposed particle tracking method, known as Suk's method, to a real field of groundwater flow and transport. Results obtained by Suk's method are compared with those obtained by Pollock's method. Suk's method produces superior tracking accuracy, which suggests that Suk's method can describe more accurately various advection-dominated transport problems in a real field than existing popular particle tracking methods, such as Pollock's method. To illustrate the wide and practical applicability of Suk's method to random-walk particle tracking (RWPT), the original RWPT has been modified to incorporate Suk's method. Performance of the modified RWPT using Suk's method is compared with the original RWPT scheme by examining the concentration distributions obtained by the modified RWPT and the original RWPT under complicated transient flow systems.

  15. A study of usability principles and interface design for mobile e-books.

    Science.gov (United States)

    Wang, Chao-Ming; Huang, Ching-Hua

    2015-01-01

    This study examined usability principles and interface designs in order to understand the relationship between the intentions of mobile e-book interface designs and users' perceptions. First, this study summarised 4 usability principles and 16 interface attributes, in order to conduct usability testing and questionnaire survey by referring to Nielsen (1993), Norman (2002), and Yeh (2010), who proposed the usability principles. Second, this study used the interviews to explore the perceptions and behaviours of user operations through senior users of multi-touch prototype devices. The results of this study are as follows: (1) users' behaviour of operating an interactive interface is related to user prior experience; (2) users' rating of the visibility principle is related to users' subjective perception but not related to user prior experience; however, users' ratings of the ease, efficiency, and enjoyment principles are related to user prior experience; (3) the interview survey reveals that the key attributes affecting users' behaviour of operating an interface include aesthetics, achievement, and friendliness. This study conducts experiments to explore the effects of users’ prior multi-touch experience on users’ behaviour of operating a mobile e-book interface and users’ rating of usability principles. Both qualitative and quantitative data analyses were performed. By applying protocol analysis, key attributes affecting users’ behaviour of operation were determined.

  16. Climatic features of atmospheric heat source/sink over theQinghai-Xizang Plateau in 35 years and its relation torainfall in China

    Institute of Scientific and Technical Information of China (English)

    ZHAO; Ping

    2001-01-01

    [1]Yeh, T. C., Gao, Y. X., The Meteorology of the Qinghai-Xizang Plateau (in Chinese), Beijing: Science Press, 1979, 2-59.[2]Ji, G. L., Yao, L. C., Yuan, F. M. et al., Characteristics of surface and atmospheric heating fields over Qinghai-Xizang Plateau during the winter in 1982, Science in China, Ser. B, 1986, 29(8): 876-888.[3]Chen. L. X., Reiter, E. R., Feng, Z. Q., The atmospheric heat source over the Tibetan plateau: May-August 1979. Mon.Wea. Rev., 1985, 113(10): 1771-1790.[4]Yanai, M., Li, C., Song, Z. S., Seasonal heating of the Tibetan plateau and its effects on the evolution of the Asian summer monsoon, Journal of the Meteorological Society of Japan, 1992, 70(1): 319-350.[5]Zhao, P., Chen, L. X., The climate characteristics of surface turbulent exchange coefficients and surface heat source over the Qinghai-Tibetan plateau, Acta Meteorologica Sinica, 2000, 14(1): 13-29.[6]Zhao, P., Chen, L. X., The calculation of solar albedo and radiation balance and the analysis of their climate characteristics over the Qinghai-Tibetan plateau, Advances in Atmospheric Sciences, 2000, 17(1): 140-156.[7]Fu, C. B., Wang, Q., The definition and detection of the abrupt climatic change, Scientia Atmospheria Sinica (in Chinese),1992. 16 (4): 482-493.

  17. Data Analysis in North Campus Research Site: How the Properties of The Aquifer Can be Characterized Best

    Science.gov (United States)

    Tang, H.; Yeh, T. C. J.; Zha, Y.; Tso, C. H. M.

    2015-12-01

    Head data from pumping tests are often used to estimate the properties of the aquifers such as hydraulic conductivity. In this study, data from 15 pumping tests in the North Campus Research Site (NCRS) in Waterloo are analyzed through hydraulic tomography (HT). A mathematical tool, Successive Linear Estimator [SLE, see Yeh et al. 1996] is used, which can effectively interpret the data collected from HT, and has been validated many times [Berg and Illman, 2011, 2013, 2014]. During the analysis, different subsets of 15 pumping tests are used to estimate the parameters (hydraulic conductivity and specific storage), ranging from 15 single tests respectively to total number of 15 tests. By interpreting and comparing the results of inversions (L2, big difference of head, head scatter, hydraulic conductivity and specific storage, etc.), we will be able to determine the importance of the number and the locations of pumping tests that are used to both characterize the aquifers well and avoid redundancy. In addition, hydrographs will also be drawn to validate the head data from pumping tests.

  18. Hydraulic Tomography at North Campus Research Site: Let Data Tell the Story

    Science.gov (United States)

    Tso, C. H. M.; Yeh, T. C. J.

    2014-12-01

    Hydraulic tomography (HT) is a sequential cross-hole hydraulic test followed by inversion of the data to map the spatial distribution of aquifer hydraulic properties (Yeh and Liu, 2000). We provide a focused, qualitative discussion on the hydraulic tomography data reported in Berg and Illman (2011). At the North Campus Research Site (NCRS) of the University of Waterloo, 8 pumping tests are conducted sequentially at different locations of the well field while drawdown is monitored at 44 ports distributed at 8 other wells. Without conducting inverse modeling, we discuss the behavior of the drawdown curves and the temporal evolution head field in response to pumping location, heterogeneity in aquifer parameters (i.e. hydraulic conductivity (K) and specific storage (Ss)), flow regimes, and boundary conditions. We emphasize the importance and direct benefits for conducting hydraulic tomography surveys relies primarily on the collection of non-redundant data, not on the inverse models. This paper attempts to use an intuitive/logical approach to qualitative hydraulic tomography analysis. Our interpretation on the aquifer heterogeneity largely agrees with the intensive core sampling (i.e. local K measurements) and inverse modeling results. We conclude some of the inspection procedures can be beneficial before the inversion of data, while the quantitative and unifying estimation of hydraulic parameter fields can only be done using an inverse model.

  19. Physics prospects of the Jinping neutrino experiment

    Science.gov (United States)

    Beacom, John F.; Chen, Shaomin; Cheng, Jianping; Doustimotlagh, Sayed N.; Gao, Yuanning; Gong, Guanghua; Gong, Hui; Guo, Lei; Han, Ran; He, Hong-Jian; Huang, Xingtao; Li, Jianmin; Li, Jin; Li, Mohan; Li, Xueqian; Liao, Wei; Lin, Guey-Lin; Liu, Zuowei; McDonough, William; Šrámek, Ondřej; Tang, Jian; Wan, Linyan; Wang, Yuanqing; Wang, Zhe; Wang, Zongyi; Wei, Hanyu; Xi, Yufei; Xu, Ye; Xu, Xun-Jie; Yang, Zhenwei; Yao, Chunfa; Yeh, Minfang; Yue, Qian; Zhang, Liming; Zhang, Yang; Zhao, Zhihong; Zheng, Yangheng; Zhou, Xiang; Zhu, Xianglei; Zuber, Kai

    2017-02-01

    The China Jinping Underground Laboratory (CJPL), which has the lowest cosmic-ray muon flux and the lowest reactor neutrino flux of any laboratory, is ideal to carry out low-energy neutrino experiments. With two detectors and a total fiducial mass of 2000 tons for solar neutrino physics (equivalently, 3000 tons for geo-neutrino and supernova neutrino physics), the Jinping neutrino experiment will have the potential to identify the neutrinos from the CNO fusion cycles of the Sun, to cover the transition phase for the solar neutrino oscillation from vacuum to matter mixing, and to measure the geo-neutrino flux, including the Th/U ratio. These goals can be fulfilled with mature existing techniques. Efforts on increasing the target mass with multi-modular neutrino detectors and on developing the slow liquid scintillator will increase the Jinping discovery potential in the study of solar neutrinos, geo-neutrinos, supernova neutrinos, and dark matter. Supported by the National Natural Science Foundation of China (11235006, 11475093, 11135009, 11375065, 11505301, and 11620101004), the Tsinghua University Initiative Scientific Research Program (20121088035, 20131089288, and 20151080432), the Key Laboratory of Particle & Radiation Imaging (Tsinghua University), the CAS Center for Excellence in Particle Physics (CCEPP), U.S. National Science Foundation Grant PHY-1404311 (Beacom), and U.S. Department of Energy under contract DE-AC02-98CH10886 (Yeh).

  20. 平面上一类两指标随机微分积方程

    Institute of Scientific and Technical Information of China (English)

    左继宏

    2000-01-01

    Yeh.J较详细地研究了方程{dX(Z)=a(Z,Xz)+β(Z,Xz)dBzz∈R+2-ЭR+2X(z)=φ(z)z∈ЭR+2系数α、β满足Lip条件和线性增长条件下方程有唯一强解。把上述方程推广到更一般方程中去(此类方程包含了一般二阶随机微分方程作为特例){dX(Z)=F(Z,X(Z),∫Rf1(Z,ξ,X(ξ))dξ,∫Rf2(Z,ξ,X(ξ))dB(ξ))dZ+G(Z,X(Z),∫Rzg1(Z,ξ,X(ξ))dξ,∫Rzg2(Z,ξ,X(ξ))dB(ξ))dB(Z)z∈R+2-ЭR+2X(z)=φ(z)z∈ЭR+2运用较Lip条件弱的条件得到强解的存在性和轨道唯一性。

  1. Acute parietal lobe infarction presenting as Gerstmann’s syndrome and cognitive decline mimicking senile dementia

    Directory of Open Access Journals (Sweden)

    Chen TY

    2013-07-01

    Full Text Available Tien-Yu Chen,1 Chun-Yen Chen,1,3 Che-Hung Yen,2,3 Shin-Chang Kuo,1,3 Yi-Wei Yeh,1,3 Serena Chang,1 San-Yuan Huang1,31Department of Psychiatry, 2Department of Neurology, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, 3Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan, Republic of ChinaAbstract: Gerstmann’s syndrome encompasses the tetrad of finger agnosia, agraphia, acalculia, and right-left confusion. An elderly man with a history of several cardiovascular diseases was initially brought to the psychiatric outpatient department by his family because of worsening of recent memory, executive function, and mixed anxious-depressive mood. Gerstmann’s syndrome without obvious motor function impairment and dementia-like features could be observed at first. Emergent brain computed tomography scan revealed new left-middle cerebral artery infarction over the left posterior parietal lobe. This case reminds us that acute cerebral infarction involving the parietal lobe may present as Gerstmann’s syndrome accompanied by cognitive decline mimicking dementia. As a result, emergent organic workups should be arranged, especially for elderly patients at high risk for cerebral vascular accident.Keywords: Gerstmann’s syndrome, dementia, parietal lobe infarction

  2. Context-free Grammars for Triangular Arrays

    Institute of Scientific and Technical Information of China (English)

    Robert X. J. HAO; Larry X. W. WANG; Harold R. L. YANG

    2015-01-01

    We consider context-free grammars of the form G={f →fb1+b2+1ga1+a2, g→fb1ga1+1}, where ai and bi are integers subject to certain positivity conditions. Such a grammar G gives rise to triangular arrays {T (n, k)}0≤k≤n satisfying a three-term recurrence relation. Many combinatorial sequences can be generated in this way. Let Tn(x)=? nk=0 T (n, k)xk. Based on the diff erential operator with respect to G, we define a sequence of linear operators Pn such that Tn+1(x)=Pn(Tn(x)). Applying the characterization of real stability preserving linear operators on the multivariate polynomials due to Borcea and Bra¨nd´en, we obtain a necessary and suffi cient condition for the operator Pn to be real stability preserving for any n. As a consequence, we are led to a suffi cient condition for the real-rootedness of the polynomials defined by certain triangular arrays, obtained by Wang and Yeh. Moreover, as special cases we obtain grammars that lead to identities involving the Whitney numbers and the Bessel numbers.

  3. A molecular model for the active site of S-adenosyl- l-homocysteine hydrolase

    Science.gov (United States)

    Yeh, Jerry C.; Borchardt, Ronald T.; Vedani, Angelo

    1991-06-01

    S-adenosyl- l-homocysteine hydrolase (AdoHcy hydrolase, EC 3.3.1.1.), a specific target for antiviral drug design, catalyzes the hydrolysis of AdoHcy to adenosine (Ado) and homocysteine (Hcy) as well as the synthesis of AdoHcy from Ado and Hcy. The enzyme isolated from different sources has been shown to contain tightly bound NAD+. Based on the 2.0 Å-resolution X-ray crystal structure of dogfish lactate dehydrogenase (LDH), which is functionally homologous to AdoHcy hydrolase, and the primary sequence of rat liver AdoHcy hydrolase, we have derived a molecular model of an extended active site for AdoHcy hydrolase. The computational mutation was performed using the software MUTAR (Yeh et al., University of Kansas, Lawrence), followed by molecular mechanics optimizations using the programs AMBER (Singh et al., University of California, San Francisco) and YETI (Vedani, University of Kansas). Solvation of the model structure was achieved by use of the program SOLVGEN (Jacober, University of Kansas); 56 water molecules were explicitly included in all refinements. Some of these may be involved in the catalytic reaction. We also studied a model of the complex of AdoHcy hydrolase with NAD+, as well as the ternary complexes of the redox reaction catalyzed by AdoHcy hydrolase and has been used to differentiate the relative binding strength of inhibitors.

  4. Commercialization of computer assisted detection: the path from science to product.

    Science.gov (United States)

    Menhardt, Wido

    2004-01-01

    Computer Assisted Detection (CAD) is a rapidly growing field with applications in a growing number of diseases, modalities, and anatomies. Academic and industrial research groups worldwide are proposing and publishing new approaches, techniques, and paradigms at an ever-increasing rate: The results are encouraging and imply the potential for dramatic improvements in disease detection and tracking. To researchers, it often seems curious that commercialization of these advances lags far behind academic progress, but there are many obstacles to be overcome, from IP management to QSR (Quality Systems Regulations) compliance, from image data and truth collection to GCP (Good Clinical Practices), from bio-statistics to proof of Safety & Effectiveness with regulatory agencies. This two-hour session is designed to shed light on experiences in CAD commercialization of innovative CAD technologies into the marketplace. The goal is to share best practices, non-competitive ideas, and "mistakes not to be repeated" among the seminar participants and with researchers in industry and academia. All speakers are involved in bringing a variety of CAD applications to market. Panelists are: Susan Wood--R2 Peter Whitehead--Quantitative Imaging Michael Yeh--Deus Chris Wood--Confirma Fred Lachmann--Medipattern Alok Gupta--Siemens Patrick Hess--Imatx Wido Menhardt--Eastman Kodak.

  5. Dietary Niche Partitioning of Euphaea formosa and Matrona cyanoptera (Odonata: Zygoptera) on the Basis of DNA Barcoding of Larval Feces.

    Science.gov (United States)

    Cheng, Yun-Chieh; Lin, Chung-Ping

    2016-01-01

    Odonate larvae are commonly considered opportunistic general predators in freshwater ecosystems. However, the dietary breadth of most odonate larvae in forest streams is still poorly documented. We characterized the prey species and estimated the level of dietary niche overlap of two damselflies, Euphaea formosa Hagen 1869 and Matrona cyanoptera Hämäläinen and Yeh, 2000 in a forest stream of central Taiwan on the basis of DNA barcoding of larval feces. A collection of 23 successfully identified cytochrome c oxidase 1 (CO1) barcoding sequences suggested that the mayflies (Ephemeroptera), caddisflies (Trichoptera), and midges (Diptera) comprise the majority (43%, 6/14) of prey species consumed by E. formosa larvae, whereas the identified prey for M. cyanoptera were mainly zooplankton (56%, 5/9). Statistical analysis of dietary overlap indicated that these two species occupy different dietary niches (Pianka's index = 0.219). DNA barcoding analysis of damselfly larval feces was effective in detecting less sclerotized prey such as vertebrates (fish and frog) and small zooplankton. However, a moderately successful rate (<70%) of PCR amplification by universal CO1 primers and a low percentage (<60%) of identifiable sequences in public databases indicate the limitations of naive DNA barcoding in fecal analysis.

  6. Intermediate divergence levels maximize the strength of structure-sequence correlations in enzymes and viral proteins.

    Science.gov (United States)

    Jackson, Eleisha L; Shahmoradi, Amir; Spielman, Stephanie J; Jack, Benjamin R; Wilke, Claus O

    2016-07-01

    Structural properties such as solvent accessibility and contact number predict site-specific sequence variability in many proteins. However, the strength and significance of these structure-sequence relationships vary widely among different proteins, with absolute correlation strengths ranging from 0 to 0.8. In particular, two recent works have made contradictory observations. Yeh et al. (Mol. Biol. Evol. 31:135-139, 2014) found that both relative solvent accessibility (RSA) and weighted contact number (WCN) are good predictors of sitewise evolutionary rate in enzymes, with WCN clearly out-performing RSA. Shahmoradi et al. (J. Mol. Evol. 79:130-142, 2014) considered these same predictors (as well as others) in viral proteins and found much weaker correlations and no clear advantage of WCN over RSA. Because these two studies had substantial methodological differences, however, a direct comparison of their results is not possible. Here, we reanalyze the datasets of the two studies with one uniform analysis pipeline, and we find that many apparent discrepancies between the two analyses can be attributed to the extent of sequence divergence in individual alignments. Specifically, the alignments of the enzyme dataset are much more diverged than those of the virus dataset, and proteins with higher divergence exhibit, on average, stronger structure-sequence correlations. However, the highest structure-sequence correlations are observed at intermediate divergence levels, where both highly conserved and highly variable sites are present in the same alignment.

  7. A HYBRID METHOD FOR ANALYZING THE DYNAMIC RESPONSES OF CAVITIES OR SHELLS BURIED IN AN ELASTIC HALF-PLANE

    Institute of Scientific and Technical Information of China (English)

    Chau-ShioungYeh; Tsung-JenTeng; Wen-ShinnShyu; I-ChangTsai

    2002-01-01

    In this paper, based on a variational formalism which originally proposed by Mei [1] for infinite elastic medium and extended by Yeh, et al. [2,3] for elastic half-plane, a hybrid method which combines the finite element and series expansion method is implemented to solve the diffraction of plane waves by a cavity buried in an elastic half-plane. The finite domain which encloses all inhomogeneities including the cavity can be easily formulated by finite element methods. The unknown boundary data obtained by subtracting the known free fields from the total fields which include the boundary nodal displacements and tractions at the interface between the finite domain and the surrounding elastic half-plane are not independent of each other and can be correlated through aseries repre sentation. Due to the continuity condition at the interface, the same series representation is still valid for the exterior elastic half-plane to represents the scattered wave. The unknown coefficients of this series are treated as generalized coordinates and can be easily formulated by the same variational principle. The expansion function of the series is composed of basis function. Each basis function is constructed from the basis function for an infinite plane by superimposing an additional homogeneous reflective term to satisfy both traction free conditions at ground surface and radiation conditions at infinity. The numerical results are made against those obtained by boundary element methods, and good agreements are found.

  8. Dietary Niche Partitioning of Euphaea formosa and Matrona cyanoptera (Odonata: Zygoptera) on the Basis of DNA Barcoding of Larval Feces

    Science.gov (United States)

    Cheng, Yun-Chieh; Lin, Chung-Ping

    2016-01-01

    Odonate larvae are commonly considered opportunistic general predators in freshwater ecosystems. However, the dietary breadth of most odonate larvae in forest streams is still poorly documented. We characterized the prey species and estimated the level of dietary niche overlap of two damselflies, Euphaea formosa Hagen 1869 and Matrona cyanoptera Hämäläinen and Yeh, 2000 in a forest stream of central Taiwan on the basis of DNA barcoding of larval feces. A collection of 23 successfully identified cytochrome c oxidase 1 (CO1) barcoding sequences suggested that the mayflies (Ephemeroptera), caddisflies (Trichoptera), and midges (Diptera) comprise the majority (43%, 6/14) of prey species consumed by E. formosa larvae, whereas the identified prey for M. cyanoptera were mainly zooplankton (56%, 5/9). Statistical analysis of dietary overlap indicated that these two species occupy different dietary niches (Pianka’s index = 0.219). DNA barcoding analysis of damselfly larval feces was effective in detecting less sclerotized prey such as vertebrates (fish and frog) and small zooplankton. However, a moderately successful rate (<70%) of PCR amplification by universal CO1 primers and a low percentage (<60%) of identifiable sequences in public databases indicate the limitations of naive DNA barcoding in fecal analysis. PMID:27432350

  9. Taxonomic corrections to species of Rhyparochromidae (Hemiptera: Heteroptera) described by Carl Peter Thunberg.

    Science.gov (United States)

    Kondorosy, Előd; Rédei, Dávid; Mejlon, Hans

    2014-07-22

    Types of Rhyparochromidae (Hemiptera: Heteroptera: Lygaeoidea) species described by Carl Peter Thunberg, deposited in the Museum of Evolution (formerly Zoologiska Institut), Uppsala University, Uppsala, Sweden, were reexamined and the taxonomic and nomenclatural problems that existed among those species discussed and resolved as required. Lectotypes are designated for Cimex caffer Thunberg, 1784, Lygaeus ater Thunberg, 1822, Lygaeus biguttatus Thunberg, 1822, and Pendulinus guttatus Thunberg, 1825. The lectotype of Pendulinus (now Metochus) guttatus is designated as neotype of Pendulinus (now Metochus) uniguttatus Thunberg, 1822; as a result the former name becomes junior objective synonym of the latter. The following taxonomic changes are proposed: Lethaeus ater (Thunberg, 1822), new combination (from Lygaeus); Migdilybs biguttatus (Thunberg, 1822), new combination (from Lygaeus) = Migdilybs furcifer Hesse, 1925, new subjective synonym; Metochus uniguttatus (Thunberg, 1822) = Metochus bengalensis (Dallas, 1852), confirmed subjective synonym = Metochus yeh (Dohrn, 1860), confirmed subjective synonym; Raglius alboacuminatus (Goeze, 1778) = Cimex caffer Thunberg, 1874, confirmed subjective synonym. Lethaeus barberi Slater, 1964 does not belong to Lethaeus Dallas, 1852 but currently it cannot be placed with confidence in any existing genus. 

  10. A new approach to the spatial analysis of temporal change using todes and neural nets.

    Directory of Open Access Journals (Sweden)

    Peter J Halls

    2000-10-01

    Full Text Available The term 'temporal' in spatial analysis has a number of potential meanings, each of which requires an alternative approach for the provision of analytic support. Much present work in spatio-temporal information is concerned with transaction versioning. Object based representations often demand a high level of initial understanding of object relationships. Many GIS users are seeking to understand the object relationships over time, past, present and future ; their research focus is how real-world features interact in time and space. Despite this requirement, little present work will support this requirement to understand the drivers of change, rather than simply to report what changed. A number of workers have / are attempting to formalise a theory of spatio-temporal reasoning (eg Hermosilla, 1994, Qian, et al, 1997, Claramunt et al, 1997, in the most part working from a theoretical abstraction. Worboys, 1998, uses a problem oriented approach, as does Halls and Miller (1995, 1996. Representation of change over time by means of spline curves offers possibilities for this type of work, Neural Networks are explored as an implementation solution. We show that the AURA neural network architecture offers particular hope and that the proposals of Yeh & de Cambray and Halls & Miller need to be recast in terms of the AURA architecture.

  11. Comparison of approaches for predicting solute transport: sandbox experiments.

    Science.gov (United States)

    Illman, Walter A; Berg, Steven J; Yeh, Tian-Chyi Jim

    2012-01-01

    The main purpose of this paper was to compare three approaches for predicting solute transport. The approaches include: (1) an effective parameter/macrodispersion approach (Gelhar and Axness 1983); (2) a heterogeneous approach using ordinary kriging based on core samples; and (3) a heterogeneous approach based on hydraulic tomography. We conducted our comparison in a heterogeneous sandbox aquifer. The aquifer was first characterized by taking 48 core samples to obtain local-scale hydraulic conductivity (K). The spatial statistics of these K values were then used to calculate the effective parameters. These K values and their statistics were also used for kriging to obtain a heterogeneous K field. In parallel, we performed a hydraulic tomography survey using hydraulic tests conducted in a dipole fashion with the drawdown data analyzed using the sequential successive linear estimator code (Yeh and Liu 2000) to obtain a K distribution (or K tomogram). The effective parameters and the heterogeneous K fields from kriging and hydraulic tomography were used in forward simulations of a dipole conservative tracer test. The simulated and observed breakthrough curves and their temporal moments were compared. Results show an improvement in predictions of drawdown behavior and tracer transport when the K tomogram from hydraulic tomography was used. This suggests that the high-resolution prediction of solute transport is possible without collecting a large number of small-scale samples to estimate flow and transport properties that are costly to obtain at the field scale.

  12. Ioannes Rauber, Oratio ad principem et senatum Venetum, 1507 : Rede eines Renaissance-Diplomaten

    Directory of Open Access Journals (Sweden)

    Primož Simoniti

    2010-12-01

    Full Text Available Kaiser Maximilian I. wollte im Jahr 1507 mit einer großen militärischen Eskorte nach Rom reisen, um sich dort endlich zum Oberhaupt des Heiligen römischen Reiches deutscher Nation krönen zu lassen. Zu diesem Zweck sandte er vom Reichstag in Konstanz eine Gesandtschaft nach Venedig, um die Durchreise durch das venezianische Territorium auszuhandeln. Er trug sich dabei mit dem Gedanken, mit Hilfe der Serenissima das von den Franzosen besetzte Mailand zurückzuerobern, die Franzosen aus Italien zu vertreiben und den Papst zur Kaiserkrönung zu zwingen. Laut Notizen des venezianischen Patriziers und Chronisten Marino Sanuto erschienen die kaiserlichen Gesandten am 21. Juni in offizieller Audienz vor dem Dogen und dem Großen Rat und Ioannes Rauber, ein Krainer aus der bekannten Krainer Adelsfamilie, Cousin des bekannten Humanisten und Mäzens, des zweiten Laibacher Bischofs Christoph Rauber, hielt die Antrittsrede. Er studierte und erwarb sich den Doktortitel beider Rechte offensichtlich in Italien und war kaiserlicher Rat und Sekretär. Während der darauf folgenden Verhandlungen, die von den Venezianern bis Mitte August hinausgezogen und schließlich mit einer abschlägigen Antwort beschieden wurden, ließ er die Rede drucken und sie in Venedig zum Kauf anbieten. In Eile und wohl versehentlich veränderte der Drucker seinen Namen in Ioannes Rebler. Raubers Oratio ad principem et senatum Venetum (am Schluß des Artikels ediert stellt ein schönes Beispiel einer zwar kurzen, rhetorisch jedoch sehr könnerisch verfassten und diplomatisch geschickt formulierten Ansprache dar, die den hohen Standards der humanistischen Rhetorik entspricht, wie sie in Italien schon längst zur Norm geworden waren. Auf die Anfangskomplimente an die Republik Venedig und den Lob der Germanen werden im Zentralabschnitt Kaiser Maximilians kriegerische und menschliche Herrschertugenden mit überschwänglichem Pomp gerühmt, um dann zur Sache zu kommen: der Redner

  13. Beneficial effects of prolonged blood pressure control after carotid artery stenting

    Directory of Open Access Journals (Sweden)

    Chang A

    2017-01-01

    Full Text Available Anna Chang,1 Huei-Fong Hung,2 Fang-I Hsieh,3 Wei-Hung Chen,1,4 Hsu-Ling Yeh,1,5 Jiann-Horng Yeh,1,6 Hou-Chang Chiu,1,6 Li-Ming Lien1,4 1Department of Neurology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, 2Department of Cardiology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, 3School of Public Health, College of Public Health, Taipei Medical University, Taipei, 4School of Medicine, College of Medicine, Taipei Medical University, Taipei, 5Institute of Public Health, National Yang-Ming University, Taipei, 6School of Medicine, College of Medicine, Fu Jen Catholic University, Taipei, Taiwan Objectives: The main purpose of this study was to investigate whether carotid artery stenting (CAS plus medicine in patients with severe carotid artery stenosis provide a better long-term blood pressure (BP control compared to other medical treatments alone. The other aim was to explore the correlation between post-CAS hypotension within 6 h and long-term BP reductions after CAS. Materials and methods: Patients with severe carotid stenosis were recruited either in the CAS group or in the medication group. BPs and the number of classes of antihypertensive agents were recorded at baseline, 6, and 12 months. Extra BP information was collected at 6 h, 3 days, and 1 month after CAS. Univariate and multivariate linear regressions were performed to test the relationship of BP changes among CAS and medication groups after 6 and 12 months of follow-up. Univariate linear regressions were also used to determine the correlations between the mean or maximal systolic BP (SBP reductions at 6 h and 1 year post-CAS. Results: In total, 72 members in the CAS group and 82 members in the medication group were recruited. Compared with the medication group, patients in the CAS group had greater BP reductions at 6 and 12 months of follow-up after adjusting for confounding factors (13.56 mmHg at 6 months, P=0.0002; 16.98 mmHg at 12 months, P<0.0001. This study also shows significant

  14. Effects of a selective educational system on fatigue, sleep problems, daytime sleepiness, and depression among senior high school adolescents in Taiwan

    Directory of Open Access Journals (Sweden)

    Chen TY

    2015-03-01

    Full Text Available Tien-Yu Chen,1,2 Yu-Ching Chou,3 Nian-Sheng Tzeng,1,2,4 Hsin-An Chang,1,2,4 Shin-Chang Kuo,1,2,5 Pei-Yin Pan,1,2 Yi-Wei Yeh,1,2,5 Chin-Bin Yeh,1,2 Wei-Chung Mao1,2,6 1Department of Psychiatry, Tri-Service General Hospital, 2School of Medicine, National Defense Medical Center, 3School of Public Health, National Defense Medical Center, 4Student Counseling Center, National Defense Medical Center, 5Graduate Institute of Medical Sciences, National Defense Medical Center, 6Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan, Republic of China Objective: The aim of the study reported here was to clarify the effects of academic pressure on fatigue, sleep problems, daytime sleepiness, and depression among senior high school adolescents in Taiwan. Methods: This cross-sectional study enrolled 757 senior high school adolescents who were classified into four groups: Grade 1 (n=261, Grade 2 (n=228, Grade 3T (n=199; Grade 3 students who had another college entrance test to take, and Grade 3S (n=69; Grade 3 students who had succeeded in their college application. Fatigue, sleep quality, daytime sleepiness, and depression were assessed using the Chinese version of the Multidimensional Fatigue Symptom Inventory – Short Form, Pittsburgh Sleep Quality Index-Taiwan Form, the Chinese version of the Epworth Sleepiness Scale, and the Chinese version of the Beck Depression Inventory®-II (BDI-II, respectively. Results: Physical, emotional, and mental fatigue scores were all higher in higher-grade groups. The Grade 3T (test students had the worst fatigue severity, and the Grade 3S (success students had the least fatigue severity. More than half of the students (60.9% went to bed after 12 am, and they had on average 6.0 hours of sleep per night. More than 30% of the students in Grade 2 (37.3% and Grades 3T/S (30.2%/30.4% possibly had daily sleepiness problems. The students in Grade 3T had the worst BDI-II score (13.27±9.24, and the Grade 3S

  15. Gaps, masses, polarization and relaxation near ν=1/2, 1/4: calculations and interpretation of experiments

    Science.gov (United States)

    Shankar, R.

    2000-03-01

    Recent experiments have determined the magnetic fields B^c at which gapped quantum Hall states jump from one quantized value of polarization P to another[1- 3] and for gapless states, the B^c's for saturation of P, [3], and the temperature dependence of P [4-5], and 1/T_1[4]. New questions arise: why is m_p, the polarization mass, so different from and m_a, the activation mass? At T>0, which should be used? Are CF's free ? I answer them using the hamiltonian theory of Composite Fermions (CF) [6-7], focusing ν=p/(2ps+ 1). This theory encodes in a hamiltonian ( of unusual form) the binding of electrons to vortices to form CF [8-9]. I compute ma near ν=1/2 and 1/4, using Zhang-Das Sarma's v(q)=2 π e^2 e^-qΛ/q (where Λ measures sample thickness), and B^c for transition from one quantized value of P to the next. I find, as Park and Jain [10] did, that the energy differences can be fit to a free fermions of mass mp though the underlying theory is interacting. I show how rotational invariance and d=2 are behind this. This tells us not to attempt to fit all data to free-field form. I compare my Hartree-Fock B^c (at T = 0); and P and 1/T1 at T>0, to experiments, taking L as a free parameter for each sample, fitting the theory to one data point. This single parameter is able to subsume the effects of interaction, disorder, and LL mixing. 1. R.R. Du, A.S. Yeh, H.L. Stormer, D.C. Tsui, L.N. Pfeifer and K.W. West, Phys. Rev. Lett., 75, 3926, (1995). 2. A.S. Yeh, H.L. Stormer, D.C. Tsui, L.N. Pfeifer, K.W. Baldwin and K.W. West, Phys. Rev. Lett. 82, 592, (1998.) 3. I.V. Kukushkin, K.V. Klitzing and K. Eberl, Phys. Rev. Lett. 82, 3 665, (1999.) 4. A.E. Dementyev, N.N. Kuzma, P. Khandelwal, S.E. Barrett, L.N. Pfeifer, and K. W. West, cond-mat/9907280. 5. S.Melinte, N. Freytag, M. Horvatic, C. Berthier, L.P. Levy, V. Bayot and M. Shayegan, cond-mat/9908098. 6. R. Shankar and G. Murthy, Phys.Rev. Lett. 79, 4437,(1997). G. Murthy and R. Shankar, in ``Composite Fermions", Editor

  16. Impact of river-lake-groundwater interaction on boundless carbon cycle in continental basin

    Science.gov (United States)

    Nakayama, T.; Shankman, D.

    2012-12-01

    In the Changjiang River in south China, deforestation and land reclamation have induced serious soil erosion and increased floods. Although the Three Gorges Dam (TGD) will provide flood control, the aquatic environment might be changed by discharge control and pollutant loads caused by the deposition of large amounts of sediment in the upper dam (Yang et al., 2006). Some research implies that seepage of groundwater along the lower regions plays important role in maintaining stream flow and after TGD impounding by using natural radionuclides (Dai et al., 2010). It is effective to clarify complicated river-lake-groundwater interaction (Eltahir and Yeh, 1999; Dai et al., 2010), and to evaluate optimum amount of transferred water and environmental consequences in the basin. The authors have so far developed the process-based National Integrated Catchment-based Eco-hydrology (NICE) model (Nakayama, 2008a, 2008b, 2010, 2011a-b, 2012a-c; Nakayama and Fujita, 2010; Nakayama and Hashimoto, 2011; Nakayama and Watanabe, 2004, 2006, 2008a, 2008b; Nakayama et al., 2006, 2007, 2010, 2012), which includes complex interactions between the forest canopy, surface water, the unsaturated zone, aquifers, lakes, and rivers. The objective of this research is to estimate the impact of river-lake-groundwater interaction on hydrologic cycle and to predict the impact of TGD on the hydrologic change in the downstream Dongting and Poyang Lakes region by using a process-based model. Analysis of power spectra in river discharge also helps to understand its complex mechanism. This integrated system also throws some light on the improvement in boundless biogeochemical cycle along terrestrial-aquatic continuum (Cole et al., 2007). References; Cole, J.J. et al., Ecosystems, doi:10.1007/s10021-006-9013-8, 2007. Dai, Z. et al., Hydrogeol. J., 18, 359-369, 2010. Eltahir, E.A.B.& Yeh, P.J.-F., Water Resour. Res., 35(4), 1199-1217, 1999. Nakayama, T., Ecol. Model., doi:10.1016/j.ecolmodel.2008

  17. Peritumoral SPARC expression and patient outcome with resectable intrahepatic cholangiocarcinoma

    Directory of Open Access Journals (Sweden)

    Cheng CT

    2015-07-01

    Full Text Available Chi-Tung Cheng,1,* Yin-Yi Chu,2,* Chun-Nan Yeh,1 Shih-Chiang Huang,3 Ming Huang Chen,4 Shang-Yu Wang,1 Chun-Yi Tsai,1 Kun-Chun Chiang,5 Yen-Yang Chen,6,7 Ming-Chun Ma,6,7 Chien-Ting Liu,6,7 Tsung-Wen Chen,1 Ta-Sen Yeh11Department of Surgery, 2Department of Gastroenterology and Hepatology, 3Department of Pathology, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan; 4Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; 5Department of Surgery, Chang Gung Memorial Hospital, Chang Gung University, Keelung, Taiwan; 6Division of Hematology and Oncology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan; 7Chang Gung University, Taoyuan, Taiwan*These authors contributed equally to this workBackground and objectives: Cholangiocarcinoma (CCA affects thousands worldwide with increasing incidence. SPARC (secreted protein acidic and rich in cysteine plays an important role in cellular matrix interactions, wound repair, and cellular migration, and has been reported to prevent malignancy from growth. SPARC undergoes epigenetic silencing in pancreatic malignancy, but is frequently expressed by stromal fibroblasts adjacent to infiltrating pancreatic adenocarcinomas. CCA is also a desmoplastic tumor, similar to pancreatic adenocarcinoma. SPARC’s clinical influence on clinicopathological characteristics of mass-forming (MF-CCA still remains unclear. In this study, we evaluate the expression of SPARC in tumor and stromal tissue to clarity its relation with prognosis.Methods: Seventy-eight MF-CCA patients who underwent hepatectomy with curative intent were enrolled for an immunohistochemical study of SPARC. The expression of immunostaining of SPARC was characterized for both tumor and stromal tissues. We conducted survival analysis with 16 clinicopathological variables. The overall survival (OS was analyzed by Kaplan–Meier analysis and Cox

  18. دور وسائل الإعلام في مكافحة الفساد العراق أنموذجاً The Role Of The Media In The Fight Against Corruption Iraq as a Model

    Directory of Open Access Journals (Sweden)

    Hatem Bedaiwi Al-Shammari حاتم بديوي الشمري

    2016-12-01

    Full Text Available still the phenomenon of corruption is a threat to citizens in all parts of the globe and growing pressure in his living and limit his freedom and became one of the most serious risks that threaten life everywhere, as far as the corruption of the factors and causes of the spread remains the media 's role to eliminate it because of its active role in raising awareness and disclosure of his hideouts and mroger and reduce zhardh through matnqlh media diverse and specialized audience of news and events variety, which is one of the main functions to him, hence the relationship between the media and society, if the media have a directive in its destruction and the warning in a broad sense so described methods of the most dangerous methods are not very effective and with a broad impact, according to media definition as an attempt to influence the minds of the masses and their souls and to control their behavior , so the address is ( the media the role of our research in the fight against the phenomenon of corruption in iraq model are searching three sections included the first part , the research methodology of the problem and the importance of the objectives and methodology and terminology as well as research tools and assumptions. the second section on corruption its causes the forms, methods and ways of its spread and the third section to ensure the media 's role in reducing these phenomenon outlined goals and means media yeh to limit this phenomenon in addition the findings and recommendations and sources for research.

  19. Effects of soil heterogeneity on steady state soil water pressure head under a surface line source

    Science.gov (United States)

    Zhang, Z. Fred; Parkin, Gary W.; Kachanoski, R. Gary; Smith, James E.

    2002-07-01

    There are numerous analytical solutions available for flow in unsaturated homogeneous porous media. In this paper, the stream tube model for one-dimensional water movement is extended to two-dimensional (2-D) water movement from a line source as the stream plane model. As well, new solutions are derived to predict the mean and variance of pressure head of water movement under a surface line source in heterogeneous soil using the perturbation method with first-order approximation (PM1) and with second-order approximation (PM2). A variance expression was also developed based on the spectral relationship presented by Yeh et al. [1985a]. The new solutions were tested using the 2-D stream plane model with parameters A = ln(α) and Y = ln(KS) and measurements from field experiments. Results show that the mean of steady state pressure head below the line source is not only a function of the mean parameter values but also a function of the variances of A and Y and the linear cross-correlation coefficient (ρ) between A and Y. The PM2 model can predict the mean pressure head accurately in heterogeneous soils at any level of correlation between A and Y, except when both the soil variability and ρ are high. The pressure head variance estimation based on the PM1 model predicts the measured variance well only when both the soil variability and ρ are low. The field experimental results show that both the PM1 and the spectral models give reasonable predictions of the pressure head variance. Both the measured and predicted values of the variance of pressure head using the two models increase with the depth of soil. Both models show that the variance of pressure head decreases as the source strength increases, but on average, the pressure head variance was underestimated by both models.

  20. Reducing drug–herb interaction risk with a computerized reminder system

    Directory of Open Access Journals (Sweden)

    Lin SS

    2015-02-01

    Full Text Available Sheng-Shing Lin,1,2 Chiu-Lin Tsai,3 Ching-Yeh Tu,3 Ching-Liang Hsieh2,4,5 1Graduate Institute of Chinese Medicine, College of Chinese Medicine, China Medical University, 2Department of Chinese Medicine, China Medical University Hospital, 3Division of Chinese Medicine, Department of Pharmacy, China Medical University Hospital, 4Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, 5Research Center for Chinese Medicine and Acupuncture, China Medical University, Taichung, Taiwan Background: Traditional Chinese medicine (TCM and Western medicine are both popular in Taiwan. Approximately 14.1% of Taiwanese residents use Western drugs and Chinese herbs concurrently; therefore, drug–herb interaction is critical to patient safety. This paper presents a new procedure for reducing the risk of drug interactions.Methods: Hospital computer systems are modified to ensure that drug–herb interactions are automatically detected when a TCM practitioner is writing a prescription. A pop-up reminder appears, warning of interactions, and the practitioner may adjust doses, delete herbs, or leave the prescription unchanged. A pharmacist will receive interaction information through the system and provide health education to the patient.Results: During the 2011–2013 study period, 256 patients received 891 herbal prescriptions with potential drug–herb interactions. Three of the 50 patients who concurrently used ginseng and antidiabetic drugs manifested hypoglycemia (fasting blood sugar level ≤70 mg/dL.Conclusion: Drug–herb interactions can cause adverse reactions. A computerized reminder system can enable TCM practitioners to reduce the risk of drug–herb interactions. In addition, health education for patients is crucial in avoiding adverse reaction by the interactions. Keywords: Traditional Chinese medicine, Western medicine, adverse reaction

  1. Neglect of the foreign invisible: Historiography and the navigation of conflicting sensibilities.

    Science.gov (United States)

    Burman, Jeremy Trevelyan

    2015-05-01

    This essay is intended first as a contribution to historiography, and only second as a contribution to the history of developmental psychology. It is therefore a discussion--primarily--of the doing of the history of psychology, rather than of its content. Briefly put: American psychology, including its associated approaches to the history of psychology, is not adequately equipped to benefit fully from the contributions of foreign scholars. To make the resulting argument clear, two archive-driven microhistories are reviewed, contrasted, augmented with new archival research, and synthesized: Yeh Hsueh's (2004) examination of the nomination process at Harvard University that led to the awarding of an honorary doctorate to Jean Piaget in 1936, and Marc Ratcliff and Paloma Borella's (2013) examination-just recently published in French-of a similar process that resulted in Piaget's hiring at Geneva in 1929 and his eventual promotion in 1940. Comparing the authors' different approaches to similar content then affords this article's larger argument: we need to broaden our sensibilities so we can see high-quality foreign contributions for what they are. Several interesting insights result if we do. Among them: although Piaget's theory is today mistakenly criticized for being asocial, and this serves as justification for countering his early works with Vygotsky's posthumous critique, it emerges from these archival studies that Piaget may have in fact chosen to present himself and his work as nonsociological (when this was not the case) for reasons unrelated to his intellectual project. Such examples then broaden the discussion of "neglect of the foreign invisible" to include suppression--even censorship (by self or other)--which in turn reflects the primary problem afforded by internationalization: by what standards are we to judge the contributions of "foreigners" into "our" discipline? (c) 2015 APA, all rights reserved).

  2. Two tyrosyl radicals stabilize high oxidation states in cytochrome c oxidase for efficient energy conservation and proton translocation

    Science.gov (United States)

    Rousseau, Denis

    2012-02-01

    The reaction of hydrogen peroxide (H2O2) with oxidized bovine cytochrome c oxidase (bCcO) was studied by electron paramagnetic resonance (EPR) to determine the properties of radical intermediates. Two distinct radicals with widths of 12 and 46 G are directly observed by X-band CW-EPR in the reaction of bCcO with H2O2 at pH 6 and pH 8. High-frequency EPR (D-band) provides assignments to tyrosine for both radicals based on well-resolved g-tensors. The 46 G wide radical has extensive hyperfine structure and can be fit with parameters consistent with Y129. However, the 12 G wide radical has minimal hyperfine structure and can be fit using parameters unique to the post-translationally modified Y244 in CcO. The results are supported by mixed quantum mechanics and molecular mechanics calculations. This study reports spectroscopic evidence of a radical formed on the modified tyrosine in CcO and resolves the much debated controversy of whether the wide radical seen at low pH in the bovine system is a tyrosine or tryptophan. A model is presented showing how radical formation and migration may play an essential role in proton translocation. This work was done in collaboration with Michelle A. Yu, Tsuyoshi Egawa, Syun-Ru Yeh and Gary J. Gerfen from Albert Einstein College of Medicine; Kyoko Shinzawa-Itoh and Shinya Yoshikawa from the University of Hyogo; and Victor Guallar from the Barcelona Supercomputing Center.

  3. Redox-controlled proton gating in bovine cytochrome c oxidase

    Science.gov (United States)

    Rousseau, Denis

    2015-03-01

    Cytochrome c oxidase is the terminal enzyme in the electron transfer chain of essentially all organisms that utilize oxygen to generate energy. It reduces oxygen to water and harnesses the energy to pump protons across the mitochondrial membrane in eukaryotes and the plasma membrane in prokaryotes. The mechanism by which proton pumping is coupled to the oxygen reduction reaction remains unresolved, owing to the difficulty of visualizing proton movement within the massive membrane-associated protein matrix. Here, with a novel hydrogen/deuterium exchange resonance Raman spectroscopy method, we have identified two critical elements of the proton pump: a proton loading site near the propionate groups of heme a, which is capable of transiently storing protons uploaded from the negative-side of the membrane prior to their release into the positive-side of the membrane and a conformational gate that controls proton translocation in response to the change in the redox state of heme a. These findings form the basis for a postulated molecular model describing a detailed mechanism by which unidirectional proton translocation is coupled to electron transfer from heme a to heme a3, associated with oxygen chemistry occurring in the heme a3 site, during enzymatic turnover. Each time heme a undergoes an oxidation-reduction transition a proton is translocated across the membrane accounting for the observation that two protons are translocated during the oxidative phase of the enzymatic cycle and two more are translocated during the reductive phase. This work was done in collaboration with Drs. Tsuyoshi Egawa and Syun-Ru Yeh. This work was supported the National Institutes of Health Grant GM098799 to D.L.R and National Science Foundation Grant NSF 0956358 to S.-R.Y.

  4. Phylogenetic and molecular analysis of food-borne shiga toxin-producing Escherichia coli.

    Science.gov (United States)

    Hauser, Elisabeth; Mellmann, Alexander; Semmler, Torsten; Stoeber, Helen; Wieler, Lothar H; Karch, Helge; Kuebler, Nikole; Fruth, Angelika; Harmsen, Dag; Weniger, Thomas; Tietze, Erhard; Schmidt, Herbert

    2013-04-01

    Seventy-five food-associated Shiga toxin-producing Escherichia coli (STEC) strains were analyzed by molecular and phylogenetic methods to describe their pathogenic potential. The presence of the locus of proteolysis activity (LPA), the chromosomal pathogenicity island (PAI) PAI ICL3, and the autotransporter-encoding gene sabA was examined by PCR. Furthermore, the occupation of the chromosomal integration sites of the locus of enterocyte effacement (LEE), selC, pheU, and pheV, as well as the Stx phage integration sites yehV, yecE, wrbA, z2577, and ssrA, was analyzed. Moreover, the antibiotic resistance phenotypes of all STEC strains were determined. Multilocus sequence typing (MLST) was performed, and sequence types (STs) and sequence type complexes (STCs) were compared with those of 42 hemolytic-uremic syndrome (HUS)-associated enterohemorrhagic E. coli (HUSEC) strains. Besides 59 STs and 4 STCs, three larger clusters were defined in this strain collection. Clusters A and C consist mostly of highly pathogenic eae-positive HUSEC strains and some related food-borne STEC strains. A member of a new O26 HUS-associated clone and the 2011 outbreak strain E. coli O104:H4 were found in cluster A. Cluster B comprises only eae-negative food-borne STEC strains as well as mainly eae-negative HUSEC strains. Although food-borne strains of cluster B were not clearly associated with disease, serotypes of important pathogens, such as O91:H21 and O113:H21, were in this cluster and closely related to the food-borne strains. Clonal analysis demonstrated eight closely related genetic groups of food-borne STEC and HUSEC strains that shared the same ST and were similar in their virulence gene composition. These groups should be considered with respect to their potential for human infection.

  5. Electroretinographic findings in transplant chorioretinopathy

    Directory of Open Access Journals (Sweden)

    Brian T Chan-Kai

    2010-07-01

    Full Text Available Brian T Chan-Kai1, Steven Yeh2, Richard G Weleber2, Peter J Francis2, Grazyna Adamus2, S Robert Witherspoon3, Andreas K Lauer11Cullen Eye Institute, Baylor College of Medicine, Houston, Texas; 2Casey Eye Institute, Oregon Health and Science University, Portland, Oregon; 3Retina Institute of Texas, Dallas, Texas, USAAim: Transplant chorioretinopathy is a rare complication following solid organ or bone ­marrow transplantation and can result in severe vision loss. This series presents electroretinogram (ERG results in patients with this condition.Methods: Patients who presented with bilateral vision loss following bone marrow or solid organ transplantation were identified. A complete ophthalmologic examination, fundus ­photography, and fluorescein angiography (FA were performed. Full-field ERG was obtained in all patients and a multifocal ERG (mfERG was obtained in two patients.Results: Four patients were identified. All patients had bilateral vision loss and displayed a characteristic pattern of mottled hyperfluorescence on FA. Three patients developed ­progressive vision loss ranging from 20/60 to hand motions whereas one retained 20/40 vision. All patients exhibited moderate to severe cone dysfunction, while the degree of rod abnormalities was varied. Two patients with severe cone dysfunction showed mild clinical changes initially, but later developed progressive vision loss and chorioretinal atrophy.Conclusion: Transplant chorioretinopathy patients undergoing ERG testing show cone ­dysfunction with a variable degree of rod dysfunction. ERG abnormalities preceded the visual acuity and clinical changes in two patients, suggesting that ERG may be a helpful predictor of the clinical course in this rare disease.Keywords: transplant, chorioretinopathy, electroretinogram, ERG, mfERG

  6. Análisis de las condiciones de fisuración en las estructuras de hormigón armado y su relación con la probabilidad de corrosión de las armaduras

    Directory of Open Access Journals (Sweden)

    Rodríguez Santiago, Jesús

    1984-12-01

    Full Text Available Cracks appears in reinforced concrete structures as something inherent to the material they are composed. Causes of diverse kind advise to control this cracking, considering it can not be prevented. The durability of reinforcements is, till now, the reason that has determined, in most structures, the study and the control of this cracking. In this report, the information contained in certain standards in force (CP-110; ACI-318-83; B.A.E.L. 80; MODEL CODE AND EH-82 about the characteristics the concrete must have and about the cracking in pieces of reinforced concrete under pliability attempts, are analysed and resumed, trying to judge later its connection with the corrosion phenomenon in reinforcements.La aparición de fisuras en las estructuras de hormigón armado es algo inherente al material de que están compuestas. Razones de índole diversa aconsejan controlar esta fisuración, ya que no puede evitarse. La durabilidad de las armaduras es hasta el momento el motivo que más ha condicionado, para la mayor parte de las estructuras, el estudio y control de dicha fisuración. En esta ponencia se analiza y compendia la información contenida en algunas normativas vigentes (CP-110; ACI-318-83; B.A.E.L. 80; CÓDIGO MODELO YEH-82 sobre las características que debe tener el hormigón y sobre la fisuración en piezas de hormigón armado bajo solicitaciones deflexión, para posteriormente tratar de enjuiciar su relación con el fenómeno de corrosión de las armaduras.

  7. Simulation of field injection experiments in heterogeneous unsaturated media using cokriging and artificial neural network

    Science.gov (United States)

    Ye, Ming; Khaleel, Raziuddin; Schaap, Marcel G.; Zhu, Jianting

    2007-07-01

    Simulations of moisture flow in heterogeneous soils are often hampered by lack of measurements of soil hydraulic parameters, making it necessary to rely on other sources of information. In this paper, we develop a methodology to integrate data that can be easily obtained (for example, initial moisture content, θi, bulk density, and soil texture) with data on soil hydraulic properties via cokriging and Artificial Neural Network (ANN)-based pedotransfer functions. The method is applied to generate heterogeneous soil hydraulic parameters at a field injection site in southeastern Washington State. Stratigraphy at the site consists of imperfectly stratified layers with irregular layer boundaries. Cokriging is first used to generate three-dimensional heterogeneous fields of bulk density and soil texture using an extensive data set of field-measured θi, which carry signature about site heterogeneity and stratigraphy. Soil texture and bulk density are subsequently input into an ANN-based site-specific pedotransfer function to generate three-dimensional heterogeneous soil hydraulic parameter fields. The stratigraphy at the site is well represented by the estimated pedotransfer variables and soil hydraulic parameters. The parameter estimates are then used to simulate a field injection experiment at the site. A relatively good agreement is obtained between the simulated and observed moisture contents. The spatial distribution pattern of observed moisture content as well as the southeastward moisture movement is captured well in the simulations. In contrast to earlier work using an effective parameter approach (Yeh et al., 2005), we are able to reproduce the observed splitting of the moisture plume in a coarse sand unit that is sandwiched between two fine-textured units. The simple method of combining cokriging and ANN for site characterization provides unbiased prediction of the observed moisture plume and is flexible so that additional measurements of various types can be

  8. Detection of Biological Materials Using Ion Mobility Spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Rodacy, P.J.; Sterling, J.P.; Butler, M.A.

    1999-03-01

    Traditionally, Ion Mobility Spectroscopy has been used to examine ions of relatively low molecular weight and high ion mobility. In recent years, however, biomolecules such as bradykinin, cytochrome c, bovine pancreatic trypsin inhibitor (BPTI), apomyoglobin, and lysozyme, have been successfully analyzed, but studies of whole bio-organisms have not been performed. In this study an attempt was made to detect and measure the mobility of two bacteriophages, {lambda}-phage and MS2 using electrospray methods to inject the viruses into the ion mobility spectrometer. Using data from Yeh, et al., which makes a comparison between the diameter of non-biologic particles and the specific particle mobility, the particle mobility for the MS2 virus was estimated to be 10{sup {minus}2} cm{sup 2}/volt-sec. From this mobility the drift time of these particles in our spectrometer was calculated to be approximately 65 msec. The particle mobility for the {lambda}-phage virus was estimated to be 10{sup {minus}3} cm{sup 2}/volt-sec. which would result in a drift time of 0.7 sec. Spectra showing the presence of a viral peak at the expected drift time were not observed. However, changes in the reactant ion peak that could be directly attributed to the presence of the viruses were observed. Virus clustering, excessive collisions, and the electrospray injection method limited the performance of this IMS. However, we believe that an instrument specifically designed to analyze such bioagents and utilizing other injection and ionization methods will succeed in directly detecting viruses and bacteria.

  9. 中国萨蜓属分类研究并记述一新种(蜻蜓目,蜓科)%NOTES ON THE CHINESE SARASAESCHNA, WITH DESCRIPTION OF A NEW SPECIES FROM FUJIAN (ODONATA, AESHNIDAE)

    Institute of Scientific and Technical Information of China (English)

    徐奇涵

    2008-01-01

    This paper treats six species of the genus Sarasaeschna Karube & Yeh in China. Sarasaeschna zhuae sp. nov. is described and illustrated from a single male. A key to the Chinese species of the genus is provided.%记述萨蜓属Sarasaeschna Karube & Yeh的中国种类共计6种,其中包括1新种,即朱氏萨蜓S.zhuae sp.nov..正模♂,福建省华安县,2007-07-05,徐奇涵采.模式标本存放在漳州城市职业学院生物标本室.给出了萨蜓属中国已知种的名录、地理分布和检索表.新种区别于萨蜓属其它种的主要特征如下:1)在萨蜓属中个体最大;2)脸部总体为棕色,仅后唇基上缘具狭小黄色横带;3)腹部第3~7节基部侧面具大而明显的黄绿色斑;4)上肛附器腹侧亚端部具1半圆形突起.正中处和近基部2/5处各具1小齿;下肛附器长达上肛附器的5/6,为萨蜓属中最长者.

  10. Enhancing E. coli isobutanol tolerance through engineering its global transcription factor cAMP receptor protein (CRP).

    Science.gov (United States)

    Chong, Huiqing; Geng, Hefang; Zhang, Hongfang; Song, Hao; Huang, Lei; Jiang, Rongrong

    2014-04-01

    The limited isobutanol tolerance of Escherichia coli is a major drawback during fermentative isobutanol production. Different from classical strain engineering approaches, this work was initiated to improve E. coli isobutanol tolerance from its transcriptional level by engineering its global transcription factor cAMP receptor protein (CRP). Random mutagenesis libraries were generated by error-prone PCR of crp, and the libraries were subjected to isobutanol stress for selection. Variant IB2 (S179P, H199R) was isolated and exhibited much better growth (0.18 h(-1) ) than the control (0.05 h(-1) ) in 1.2% (v/v) isobutanol (9.6 g/L). Genome-wide DNA microarray analysis revealed that 58 and 308 genes in IB2 had differential expression (>2-fold, p < 0.05) in the absence and presence of 1% (v/v) isobutanol, respectively. When challenged with isobutanol, genes related to acid resistance (gadABCE, hdeABD), nitrate reduction (narUZYWV), flagella and fimbrial activity (lfhA, yehB, ycgR, fimCDF), and sulfate reduction and transportation (cysIJH, cysC, cysN) were the major functional groups that were up-regulated, whereas most of the down-regulated genes were enzyme (tnaA) and transporters (proVWX, manXYZ). As demonstrated by single-gene knockout experiments, gadX, nirB, rhaS, hdeB, and ybaS were found associated with strain isobutanol resistance. The intracellular reactive oxygen species (ROS) level in IB2 was only half of that of the control when facing stress, indicating that IB2 can withstand toxic isobutanol much better than the control.

  11. The preparation and characterization of gold-conjugated polyphenol nanoparticles as a novel delivery system

    Directory of Open Access Journals (Sweden)

    Hsieh DS

    2012-03-01

    Full Text Available Dar-Shih Hsieh1,2, Hsiu-Chin Lu5, Cheng-Cheung Chen1,3, Chang-Jer Wu1,*, Ming-Kung Yeh4,* 1Department of Food Science, National Taiwan Ocean University, Keelung, Taiwan; 2Division of Urology, 3Department of Pathology, Tri-Service General Hospital, 4Institute of Preventive Medicine, National Defence Medical Center, Taipei, Taiwan; 5Department of Laboratory Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan*These authors contributed equally to this workAbstract: Nanogold particles are commonly used in nanomedicine. We generated physical nanogold (pNG conjugated with different ratios of epigallocatechin-3-gallate (EGCG and evaluated its physicochemical properties, antioxidant activity, and cytotoxicity in vitro as well as anticancer activity in vivo. Results showed that the EGCG-pNG conjugates were successfully prepared at ratios between 23:1 and 23:5, with the percentage of EGCG content increasing with the EGCG:pNG ratio from 23:1 (2.0% ± 0.02% to 23:5 (28% ± 0.3%. EGCG-pNG particles at ratios of 23:1 and 23:5 demonstrated significantly decreased size from 500 to 20 nm and decreasing zeta potentials of 21 mV to –22 mV, respectively. At a ratio of 23:2.5, the EGCG-pNG particles (27% EGCG, 50 nm in size, zeta potential of –8 mV showed longer EGCG activity half-life (110 days vs 5 hours, controlled release (2 hours vs 30 minutes, and higher antioxidant activity (four times, as well as inhibition of tumor cell growth, than controls. The present study indicated that EGCG-pNG possesses promising therapeutic potential, based on its strong free-radical scavenging and anticancer activities.Keywords: EGCG, nanoparticles, antioxidant, antitumor activity, nanogold

  12. Enhancement of tendon–bone healing via the combination of biodegradable collagen-loaded nanofibrous membranes and a three-dimensional printed bone-anchoring bolt

    Directory of Open Access Journals (Sweden)

    Chou YC

    2016-08-01

    Full Text Available Ying-Chao Chou,1,2 Wen-Lin Yeh,2 Chien-Lin Chao,1 Yung-Heng Hsu,1,2 Yi-Hsun Yu,1,2 Jan-Kan Chen,3 Shih-Jung Liu1,2 1Department of Mechanical Engineering, Chang Gung University, 2Department of Orthopedic Surgery, Chang Gung Memorial Hospital, 3Department of Physiology and Pharmacology, Chang Gung University, Taoyuan, Taiwan Abstract: A composite biodegradable polymeric model was developed to enhance tendon graft healing. This model included a biodegradable polylactide (PLA bolt as the bone anchor and a poly(D,L-lactide-co-glycolide (PLGA nanofibrous membrane embedded with collagen as a biomimic patch to promote tendon–bone interface integration. Degradation rate and compressive strength of the PLA bolt were measured after immersion in a buffer solution for 3 months. In vitro biochemical characteristics and the nanofibrous matrix were assessed using a water contact angle analyzer, pH meter, and tetrazolium reduction assay. In vivo efficacies of PLGA/collagen nanofibers and PLA bolts for tendon–bone healing were investigated on a rabbit bone tunnel model with histological and tendon pullout tests. The PLGA/collagen-blended nanofibrous membrane was a hydrophilic, stable, and biocompatible scaffold. The PLA bolt was durable for tendon–bone anchoring. Histology showed adequate biocompatibility of the PLA bolt on a medial cortex with progressive bone ingrowth and without tissue overreaction. PLGA nanofibers within the bone tunnel also decreased the tunnel enlargement phenomenon and enhanced tendon–bone integration. Composite polymers of the PLA bolt and PLGA/collagen nanofibrous membrane can effectively promote outcomes of tendon reconstruction in a rabbit model. The composite biodegradable polymeric system may be useful in humans for tendon reconstruction. Keywords: polylactide–polyglycolide nanofibers, PLGA, collagen, 3D printing, polylactide, PLA, bone-anchoring bolts, tendon healing

  13. 玩味设计%WITH RUMINATION

    Institute of Scientific and Technical Information of China (English)

    吴韵

    2010-01-01

    @@ 设计是一种玩味的哲学.人们日常生活中使用的家具、陈设品,被现代设计师们重新审视制作,便成为了人们生活中极具趣味性的存在.现代人看待设计的方式是如此的不同,设计的价值已经不仅仅涵盖其功能本身.而从设计师们的设计中,人们可以清楚地看到他们的梦想甚至个性,可以说他们的作品便是其最鲜明的个人标签. 设计师Kenyon Yeh,2007年毕业于台湾东海大学,2009年获得伦敦金斯顿大学艺术硕士学位,主修工业设计.如今他在伦敦生活,是一个活跃在家具和产品设计界的自由设计师. 当今这个时代,设计与艺术正处在一个不断影响和融合的过程当中.艺术家也是设计师,设计师也是艺术家,也可以说设计正在寻求新的定义.

  14. The L(2,1)-labeling Problem on Several Classes of Graphs%关于几类图的L(2,1)标号问题

    Institute of Scientific and Technical Information of China (English)

    邵振东; 刘家壮

    2004-01-01

    An L(2,1) labeling of a graph G is a function f from the vertex set V(G) to the set of all nonnegative integers such that | f(x) - f(y)|≥ 2 ifd(x,y) = 1 and |f(x) - f(y) |≥ 1 if d(x,y) = 2. The L(2,1)- labeling number λ(G) of G is the smallest number k such that G has an L(2,1)-labeling with max{ f(v): v ∈ V(G)) = k. Griggs and Yeh conjecture thatλ(G) ≤△2 for any simple graph with maximum degree△. In this paper, we derive the upper bounds of λ(G) of Kneser graph,Mycielski graph,Descartes graph, Halin graph, and prove that the conjecture is true for the above several classes of graphs.%图G的L(2,1)标号是一个从顶点集V(G)到非负整数集的函数f(x),使得若d(x,y)=1,则 |f(x)-f(y)|≥2;若d(x,y)=2,则 |f(x)-f(y)|≥1.图G的L(2,1)-标号数λ(G)是使得G有max{f(v):v∈V(G)}=k的L(2,1)标号中的最小数k.Griggs和Yeh猜想对最大度为△的一般图G,有λ(G)≤△2.本文给出了Kneser图,Mycieklski图,Descartes图,Halin图的λ值的上界,并证明了上述猜想对以上几类图成立.

  15. The Communication Link and Error ANalysis (CLEAN) simulator

    Science.gov (United States)

    Ebel, William J.; Ingels, Frank M.; Crowe, Shane

    1993-01-01

    During the period July 1, 1993 through December 30, 1993, significant developments to the Communication Link and Error ANalysis (CLEAN) simulator were completed and include: (1) Soft decision Viterbi decoding; (2) node synchronization for the Soft decision Viterbi decoder; (3) insertion/deletion error programs; (4) convolutional encoder; (5) programs to investigate new convolutional codes; (6) pseudo-noise sequence generator; (7) soft decision data generator; (8) RICE compression/decompression (integration of RICE code generated by Pen-Shu Yeh at Goddard Space Flight Center); (9) Markov Chain channel modeling; (10) percent complete indicator when a program is executed; (11) header documentation; and (12) help utility. The CLEAN simulation tool is now capable of simulating a very wide variety of satellite communication links including the TDRSS downlink with RFI. The RICE compression/decompression schemes allow studies to be performed on error effects on RICE decompressed data. The Markov Chain modeling programs allow channels with memory to be simulated. Memory results from filtering, forward error correction encoding/decoding, differential encoding/decoding, channel RFI, nonlinear transponders and from many other satellite system processes. Besides the development of the simulation, a study was performed to determine whether the PCI provides a performance improvement for the TDRSS downlink. There exist RFI with several duty cycles for the TDRSS downlink. We conclude that the PCI does not improve performance for any of these interferers except possibly one which occurs for the TDRS East. Therefore, the usefulness of the PCI is a function of the time spent transmitting data to the WSGT through the TDRS East transponder.

  16. The Role of Intraseasonal Atmosphere Variability in ENSO Generation in Future Climate

    Science.gov (United States)

    Matveeva, Tatiana; Gushchina, Daria

    2016-04-01

    The intraseasonal tropical variability (ITV) is a general component of the atmospheric circulation in the tropics, particularly, it plays the main role in the formation of El Niño-Southern Oscillation (ENSO). The ENSO is the general mode of interannual climate variability. It appears in two kinds of large-scale sea surface temperature (SST) anomalies in the equatorial Pacific Ocean: East Pacific (EP) El Niño (named also Canonical El Niño) characterized by anomalous warming in the eastern Pacific, and Central Pacific (CP) El Niño (so-called El Niño Modoki) with maximum SST anomalous in the center of the Pacific Ocean [Kao and Yu, 2009; Kug et al., 2009]. The ability of CMIP5 coupled ocean-atmosphere general circulation models (CGCMs) to simulate two flavors of El Niño is estimated using Empirical orthogonal functions (EOFs) analysis of SST anomalies fields (Experiment Pi-Control), in this study we assessed 20 CGCMs. Spatial distribution of the first mode (EOF 1) represents SST anomalies field structure of EP El Niño and the second mode (EOF 2) is analogue of SST anomalies spatial distribution during CP El Niño [Ashok et al., 2007]. To identify intensity and frequency ENSO we also considered both NINO3 and NINO4 SST indices. NINO3 and NINO4 regions have been defined based on EOF-analysis (EOF 1 and EOF 2, resp.). It's shown that only several models were able to simulate two kinds of ENSO. Then we tested chosen CGCMs' ability to correct simulation of ITV components. For identification ITV components in the tropical troposphere we applied double space-time Fourier analysis to zonal wind at 850 hPa (U850), following the method of WK99 [Wheler and Kiladis, 1999]. Then we defined wave activity and analyzed spatial pattern of the waves and relationship between the waves and ENSO. Besides, it is shown that the ITV characteristics are altered during different flavors of ENSO [Gushchina and Dewitte, 2012]. In [Yeh et al., 2009] it has been established that the ratio

  17. Multiple Sclerosis in Children

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    Soroor INALOO

    2013-06-01

    ;59(7:1006-10.10. Yavari MJ, Inaloo S, Saboori S. Multiple sclerosis in children: A review of clinical and paraclinical features in26 cases. Iran J Child Neurol 2008;2(4:41-46.11. Oksenberg JR, Baranzini SE, Sawcer S, Hauser SL. The genetics of multiple sclerosis: SNPs to pathways to pathogenesis. Nat Rev Genet 2008 Jul;9(7:516-26.12. Willer CJ, Dyment DA, Risch NJ, Sadovnick AD, Ebers GC; Canadian Collaborative Study Group. Twin concordance and sibling recurrence rates in multiple sclerosis. Proc Natl Acad Sci USA 2003 Oct 28;100(22:12877-82.13. Ramagopalan SV, Knight JC, Ebers GC. Multiple sclerosis and the major histocompatibility complex. Curr Opin Neurol 2009 Jun;22(3:219-25.14. Banwell B, Krupp L, Kennedy J, Tellier R, Tenembaum S, Ness J, et al. Clinical features and viral serologies in children with multiple sclerosis: a multinational observational study. Lancet Neurol 2007 Sep;6(9:773-81.15. Alotaibi S, Kennedy J, Tellier R, Stephens D, Banwell B. Epstein Barr virus in pediatric multiple sclerosis. JAMA2004;291(15:1875-9.16. Pohl D, Knone B, Rostasy K, Kahler E, Brunner E, Lehnert M, et al. High seroprevalence of Epstein-Barr virus in children with multiple sclerosis. Neurology 2006 Dec12;67(11:2063-5.17. Waubant E, Mowry EM, Krupp L, Chitnis T, Yeh EA, Kuntz N,et al. Antibody response to common viruses and human leukocyte antigen-DRB1 in pediatric multiple sclerosis. Mult Scler. 2012 Dec 11.18. Waubant E, Mowry EM, Krupp L, Chitnis T, Yeh EA, Kuntz N, et al. Common viruses associated with lower pediatric multiple sclerosis risk. Neurology 2011 Jun 7;76(23:1989-95.19. Mikaeloff Y, Caridade G, Rossier M, Suissa S, Tardieu M. Hepatitis B vaccination and the risk of childhoodonsetmultiple sclerosis. Arch Pediatric Adolesc Med 2007;161:1176-82.20. Hammord SR, English DR, Moleod JG. The age-range of risk of developing multiple sclerosis. Brain. 2000 May;123 (Pt 5:968-74.21. Van Amerongen BM, Dijkstra CD, Lips P, Polman CH. Multiple sclerosis and vitamin D: an update. Eur J Clin

  18. Quadro clínico do lobo orbitário com crises cerebelares: Cisticercose racemosa do ângulo ponto-cerebelar

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    Aníbal Silveira

    1960-06-01

    após a primeira discussão clínica do quadro, quando obtido o exame completo do líquor, o diagnóstico etiológico pôde ser aventado. O exame neuro-oftalmológico foi ainda negativo. A evolução dos sintomas levou o doente à obnubilação e ao embotamento intelectuais, à espurcícia; e, pelo lado neurológico, à impossibilidade de locomoção, à ataxia do tronco, ao relaxamento dos esfincteres. Diagnóstico: quadro neuropsiquiátrico orbitario, como repercussão de alterações ponto-cerebelares; cisticercose provável. O paciente faleceu 11 meses após a internação. A necropsia revelou, quanto ao sistema nervoso central, um cacho de vesículas de cisticerco racemoso ao nível do ângulo ponto-cerebelar direito (fig. 1 e espessamento das leptomeninges na base do encéfalo até a dos lobos temporais. Nenhuma alteração histológica do córtex cerebral ou das vias intra-hemisféricas (Nissl e Weil. Quanto ao aspecto patogênico, o quadro orbitario descrito por Kleist era representado pela falência na manutenção do esfôrço e da atividade em geral (Ausdauer, na regência instintiva dos atos (gesinnungsmässige Handlungen, bem como pelo distúrbio teatral, tipo pitiático, do caráter (Gesin-nung. Os transtornos neurológicos e mesmo neurovegetativos correspondiam, na opinião dos autores, à falência paleocerebelar.

  19. Repeated adjacent segment diseases and fractures in osteoporotic patients: a case report

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    Chen HY

    2016-07-01

    Full Text Available Hsin-Yao Chen,1 Chiu-Liang Chen,1,2 Wei-Liang Chen3 1Department of Orthopedic Surgery, Changhua Christian Hospital, Changhua City, 2Liberal Arts Center of Da Yeh University, Dacun Township, Changhua County, Taiwan; 3Department of Clinical Image, Changhua Christian Hospital, Changhua City, Changhua County, Taiwan Background: Pedicle screw instrumentation for treating spinal disorder is becoming increasingly widespread. Many studies have advocated its use to facilitate rigid fixation for spine; however, adjacent segmental disease is a known complication. Instrumented fusion for osteoporotic spines remains a significant challenge for spine surgeons. Prophylactic vertebroplasty for adjacent vertebra has been reported to reduce the complications of junctional compression fractures but has raised a new problem of vertebral subluxation. This case report is a rare and an extreme example with many surgical complications caused by repeated instrumented fusion for osteoporotic spine in a single patient. This patient had various complications including adjacent segmental disease, vertebral subluxation, and junctional fractures on radiographs and magnetic resonance images.Case presentation: An 81-year-old Taiwanese woman underwent decompression and instrumented fusion of L4-L5 in Taiwan 10 years ago. Due to degenerative spinal stenosis of L3-L4 and L2-L3, she had decompression with instrumented fusion from L5 to L1 at the previous hospital. However, catastrophic vertebral subluxations with severe neurologic compromise occurred, and she underwent salvage surgeries twice with prolonged instrumented fusion from L5 to T2. The surgeries did not resolve her problems of spinal instability and neurologic complications. Eventually, the patient remained with a Frankel Grade C spinal cord injury.Conclusion: Adjacent segmental disease, junctional fracture, and vertebral subluxation are familiar complications following instrumented spinal fusion surgeries for

  20. Influence of charge on FITC-BSA-loaded chondroitin sulfate-chitosan nanoparticles upon cell uptake in human Caco-2 cell monolayers

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    Hu CS

    2012-09-01

    Full Text Available Chieh-shen Hu,1 Chiao-hsi Chiang,2 Po-da Hong,1,4,* Ming-kung Yeh1–3,*1Biomedical Engineering Program, Graduate Institute of Applied Science and Technology, National Taiwan University of Science and Technology; 2School of Pharmacy, National Defence Medical Center; 3Bureau of Pharmaceutical Affairs, Ministry of National Defence Medical Affairs Bureau; 4Department of Materials Science and Engineering, National Taiwan University of Science and Technology, Taiwan, Republic of China*These authors contributed equally to this workBackground and methods: Chondroitin sulfate-chitosan (ChS-CS nanoparticles and positively and negatively charged fluorescein isothiocyanate-conjugated bovine serum albumin (FITC-BSA-loaded ChS-CS nanoparticles were prepared and characterized. The properties of ChS-CS nanoparticles, including cellular uptake, cytotoxicity, and transepithelial transport, as well as findings on field emission-scanning electron microscopy, transmission electron microscopy, and confocal laser scanning microscopy were evaluated in human epithelial colorectal adenocarcinoma (Caco-2 fibroblasts. ChS-CS nanoparticles with a mean particle size of 250 nm and zeta potentials ranging from –30 to +18 mV were prepared using an ionic gelation method.Results: Standard cell viability assays demonstrated that cells incubated with ChS-CS and FITC-BSA-loaded ChS-CS nanoparticles remained more than 95% viable at particle concentrations up to 0.1 mg/mL. Endocytosis of nanoparticles was confirmed by confocal laser scanning microscopy and measured by flow cytometry. Ex vivo transepithelial transport studies using Caco-2 cells indicated that the nanoparticles were effectively transported into Caco-2 cells via endocytosis. The uptake of positively charged FITC-BSA-loaded ChS-CS nanoparticles across the epithelial membrane was more efficient than that of the negatively charged nanoparticles.Conclusion: The ChS-CS nanoparticles fabricated in this study were

  1. Amsacrine analog-loaded solid lipid nanoparticle to resolve insolubility for injection delivery: characterization and pharmacokinetics

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    Fang YP

    2016-03-01

    Full Text Available Yi-Ping Fang,1 Chih-Hung Chuang,2 Pao-Chu Wu,1 Yaw-Bin Huang,1 Cherng-Chyi Tzeng,3 Yeh-Long Chen,3 Ya-Ting Liu,1 Yi-Hung Tsai,1 Ming-Jun Tsai4–6 1School of Pharmacy, College of Pharmacy, 2Department of Biomedical and Environment Biology, College of Life Science, 3School of Medicinal and Applied Chemistry, College of Life Science, Kaohsiung Medical University, Kaohsiung, 4Department of Neurology, China Medical University Hospital, 5School of Medicine, Medical College, China Medical University, Taichung, 6Department of Neurology, China Medical University An-Nan Hospital, Tainan, Taiwan Abstract: Amsacrine analog is a novel chemotherapeutic agent that provides potentially broad antitumor activity when compared to traditional amsacrine. However, the major limitation of amsacrine analog is that it is highly lipophilic, making it nonconductive to intravenous administration. The aim of this study was to utilize solid lipid nanoparticles (SLN to resolve the delivery problem and to investigate the biodistribution of amsacrine analog-loaded SLN. Physicochemical characterizations of SLN, including particle size, zeta potential, entrapment efficiency, and stability, were evaluated. In vitro release behavior was also measured by the dialysis method. In vivo pharmacokinetics and biodistribution behavior of amsacrine analog were investigated and incorporated with a non invasion in vivo imaging system to confirm the localization of SLN. The results showed that amsacrine analog-loaded SLN was 36.7 nm in particle size, 0.37 in polydispersity index, and 34.5±0.047 mV in zeta potential. More than 99% of amsacrine analog was successfully entrapped in the SLN. There were no significant differences in the physicochemical properties after storage at room temperature (25°C for 1 month. Amsacrine analog-loaded SLN maintained good stability. An in vitro release study showed that amsacrine analog-loaded SLN sustained a release pattern and followed the zero equation. An

  2. Self-nanoemulsifying drug delivery systems ameliorate the oral delivery of silymarin in rats with Roux-en-Y gastric bypass surgery

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    Chen CH

    2015-03-01

    Full Text Available Chun-Han Chen,1,2 Cheng-Chih Chang,1 Tsung-Hsien Shih,2 Ibrahim A Aljuffali,3 Ta-Sen Yeh,4,5 Jia-You Fang6–8 1Division of General Surgery, Department of Surgery, Chang Gung Memorial Hospital, Chiayi, 2Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Kweishan, Taoyuan, Taiwan; 3Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia; 4Department of Surgery, Chang Gung Memorial Hospital, 5School of Medicine, College of Medicine, 6Pharmaceutics Laboratory, Graduate Institute of Natural Products, 7Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, 8Research Center for Industry of Human Ecology, Chang Gung University of Science and Technology, Kweishan, Taoyuan, Taiwan Abstract: Roux-en-Y gastric bypass (RYGB is a popular surgery to reduce the body weight of obese patients. Although food intake is restricted by RYGB, drug absorption is also decreased. The purpose of this study was to develop novel self-nanoemulsifying drug delivery systems (SNEDDS for enhancing the oral delivery of silymarin, which has poor water solubility. The SNEDDS were characterized by size, zeta potential, droplet number, and morphology. A technique of RYGB was performed in Sprague-Dawley rats. SNEDDS were administered at a silymarin dose of 600 mg/kg in normal and RYGB rats for comparison with silymarin aqueous suspension and polyethylene glycol (PEG 400 solution. Plasma silibinin, the main active ingredient in silymarin, was chosen for estimating the pharmacokinetic parameters. SNEDDS diluted in simulated gastric fluid exhibited a droplet size of 190 nm with a spherical shape. The nanocarriers promoted silibinin availability via oral ingestion in RYGB rats by 2.5-fold and 1.5-fold compared to the suspension and PEG 400 solution, respectively. A significant double-peak concentration of silibinin was detected for RYGB rats receiving SNEDDS. Fluorescence

  3. The comparison of protein-entrapped liposomes and lipoparticles: preparation, characterization, and efficacy of cellular uptake

    Directory of Open Access Journals (Sweden)

    Chang WK

    2011-10-01

    Full Text Available Wei-Kuo Chang1, Yu-Ju Tai2, Chiao-Hsi Chiang3, Chieh-Shen Hu2, Po-Da Hong2, Ming-Kung Yeh3,4 1Division of Gastroenterology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taiwan, ROC; 2Graduate Institute of Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan, ROC; 3School of Pharmacy, National Defense Medical Center, Taipei, Taiwan, ROC; 4Institute of Preventive Medicine, National Defense Medical Center, Sanhsia, Taipei, Taiwan, ROC Abstract: Fluorescein isothiocyanate-conjugated bovine serum albumin (FITC-BSA-loaded polyethylene glycol (PEG-modified liposomes and lipoparticles with high protein entrapment were developed. The lipid formula of the liposomes contained PEGylated lipids and unsaturated fatty acids for enhancing membrane fluidity and effective delivery into cells. The preparation techniques, lipid content, and PEG-modified lipoparticle ratios were evaluated. The PEG-modified lipoparticles prepared by ethanol injection extrusion (100 nm pore size achieve a population of blank liposomes with a mean size of 125 ± 2.3 nm and a zeta potential of —12.4 ± 1.5 mV. The average particle size of the PEG-modified lipoparticles was 133.7 ± 8.6 nm with a zeta potential of +13.3 mV. Lipoparticle conformation was determined using transmission electron microscopy and field-emission scanning electron microscopy. The FITC-BSA encapsulation efficiency was dramatically increased from 19.0% for liposomes to 59.7% for lipoparticles. Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE results confirmed the preparation process, and an 8-hour leaching test did not harm the protein structure. Once prepared, the physical and chemical stability of the PEG-modified lipoparticle formulations was satisfactory over 90 days. In vitro retention tests indicated that the 50% retention time for the protein-containing lipoparticles was 7.9 hours, substantially longer than

  4. Social support received by multidrug-resistant tuberculosis patients and related factors: a cross-sectional study in Zhejiang Province, People's Republic of China

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    Chen B

    2016-06-01

    Full Text Available Bin Chen,1 Yin Peng,1 Lin Zhou,1 Chengliang Chai,1 Hui-Chi Yeh,2 Songhua Chen,1 Fei Wang,1 Mingwu Zhang,1 Tieniu He,1 Xiaomeng Wang1 1Department of Tuberculosis Control and Prevention, Zhejiang Provincial Center for Disease Control and Prevention, Binjiang District, Hangzhou, People’s Republic of China; 2Politics & International Relations, Social Sciences, University of Southampton, Southampton, UK Objectives: The objective of this study is to assess the social support received by patients diagnosed with multidrug-resistant tuberculosis (MDR-TB in Zhejiang Province, People’s Republic of China and the factors that may have influenced it. Methods: A total of 220 MDR-TB patients participated in the questionnaire-based survey, and the data from 212 valid questionnaires were analyzed. The respondents reported their sociodemographic status, disease features, and attitudes toward the disease. The social support rating scale was used to measure the patients’ social support scores. An Independent Samples t-test, one-way analysis of variance, and a multiple linear regression model were used to analyze the related factors for the social support scores. Result: The average social support score of each MDR-TB patient was 32.56±7.86. Participants who were single, widowed or divorced, retired, and had fewer family members and lower family income were found to have lower social support scores. Participants unwilling to disclose their disease tended to have less social support (31.59<34.23, P=0.010. Participants who perceived great help from health care workers reported higher social support rating scale scores than those who perceived no help (35.36>29.89, P=0.014. Conclusion: MDR-TB patients in Zhejiang Province were shown to have a low level of social support. Patients who were not married, had smaller families, and lower family income received less social support, suggesting that family harmony could be an important source of social support. Patients

  5. FOLFIRI and regorafenib combination therapy with dose escalation of irinotecan as fourth-line treatment for patients with metastatic colon cancer according to UGT1A1 genotyping

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    Lu CY

    2014-11-01

    Full Text Available Chien-Yu Lu,1,2 Yung-Sung Yeh,3–5 Ching-Wen Huang,5,6, Cheng-Jen Ma,4,5 Fang-Jung Yu,1,2 Jaw-Yuan Wang4–10 1Division of Gastroenterology, Department of Internal Medicine, 2Department of Internal Medicine, Faculty of Medicine, College of Medicine, 3Department of Emergency Medicine, Kaohsiung Municipal Hsiao-Kang Hospital, 4Graduate Institute of Clinical Medicine, College of Medicine, 5Division of Gastroenterology and General Surgery, Department of Surgery, Kaohsiung Medical University Hospital, 6Graduate Institute of Medicine, College of Medicine, 7Cancer Center, Kaohsiung Medical University Hospital, 8Department of Genomic Medicine, 9Department of Surgery, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; 10Center for Biomarkers and Biotech Drugs, Kaohsiung Medical University, Kaohsiung, Taiwan Abstract: Here we report a case of metastatic colon cancer treated with 5-fluorouracil, leucovorin, and escalated doses of irinotecan (FOLFIRI combined with regorafenib in the fourth-line setting after uridine diphosphate glucuronosyltransferase (UGT1A1 genotyping analysis. A 66-year-old male was initially diagnosed with Union Internationale Contre le Cancer stage III descending colon cancer and underwent curative surgery. He received postoperative adjuvant chemotherapy; however, liver metastasis developed and a partial hepatectomy was performed thereafter. Unfortunately, pulmonary metastases and recurrent liver tumors were found despite a series of systemic treatments with multiple combinations of cytotoxic and biologic agents. Recently, a novel multikinase inhibitor, regorafenib, was approved for the treatment of metastatic colorectal cancer refractory to other therapeutic modalities. As further treatment, we combined regorafenib with FOLFIRI, which included dose escalations of irinotecan, after UGT1A1 genotyping analysis. The therapeutic results were promising, with the improvement in liver and pulmonary metastases being

  6. 3D seismic structure of the Zhenbei-Huangyan seamount chain in the East sub-basin of the South China Sea and its mechanism of formation

    Science.gov (United States)

    Zhao, M.; Wang, J.; Qiu, X.; Sibuet, J. C.; He, E.; Zhang, J.

    2015-12-01

    The post-spreading volcanic ridge (PSVR) is oriented approximately E-W in its western part called the Zhenbei-Huangyan seamount chain. Where is the extinct spreading ridge (ESR) of the East Sub-basin located? beneath the PSVR (Li et al., 2014)? Or intersecting with the PSVR by N055° orientation (Sibuet et al., submitted)? A three-dimensional Ocean Bottom Seismometer (OBS) survey covered both the central extinct spreading ridge and the Zhenbei-Huangyan seamount chain, the IODP Site U1431 (Li et al., 2014) being located just north of the chain. The results of this experiment will provide the essential information to understand the emplacement of the PSVR within the previously formed oceanic crust. The comprehensive seismic record sections of 39 OBSs are of high quality and show clear and reliable P-wave seismic phases, such as Pg, Pn and PmP. These seismic arrivals provide strong constrains for modeling the detailed three-dimensional velocity structure. We will show that the crust is oceanic on each side of the Zhenbei-Huangyan seamount chain, where is the location of the ESR and what is the genetic relationship between the magma chambers and the overlying Zhenbei-Huangyan seamount chain. We suggest that the large thickness of the upper crust is possibly due to volcanic extrusions and the thickened lower crust to magmatic underplating. Combining previous geochemical study of PSVR outcropping samples, the formation mechanism of the seamount chain might be explained by a buoyancy decompression melting mechanism (Castillo et al., 2010). This research was granted by the Natural Science Foundation of China (91028002, 91428204, 41176053). ReferencesSibuet J.-C., Yeh Y.-C. and Lee C.-S., 2015 submitted. Geodynamics of the South China Sea: A review with emphasis on solved and unsolved questions. Tectonophysics. Li, C. F., et al. 2014. Ages and magnetic structures of the South China Sea constrained by deep tow magnetic surveys and IODP Expedition 349. Geochemistry

  7. Image-guided intensity-modulated radiotherapy for refractory bilateral breast cancer in a patient with extensive cutaneous metastasis in the chest and abdominal walls

    Directory of Open Access Journals (Sweden)

    Lu YF

    2016-05-01

    Full Text Available Yueh-Feng Lu,1 Yu-Chin Lin,2 Kuo-Hsin Chen,3,4 Pei-Wei Shueng,1 Hsin-Pei Yeh,1 Chen-Hsi Hsieh1,5,6 1Division of Radiation Oncology, Department of Radiology, 2Division of Oncology and Hematology, Department of Medicine, 3Department of Surgery, Far Eastern Memorial Hospital, New Taipei City, 4Department of Electrical Engineering, Yuan-Ze University, Taoyuan, 5Department of Medicine, 6Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan Abstract: Treatment for bilateral breast cancer with chest wall and abdominal skin invasion normally involves conventional radiotherapy (RT; however, conventional RT provides inadequate target volume coverage and excessive treatment of large volumes of normal tissue. Helical tomotherapy (HT has the ability to deliver continuous craniocaudal irradiation that suppresses junction problems and provides good conformity of dose distribution. A 47-year-old female with stage IV bilateral breast cancer with chest wall and pectoralis major muscle invasion, lymphadenopathy, bilateral pleural effusion, and multiple bone metastases received chemotherapy and target therapy beginning in January 2014; 4 months after the initiation of chemotherapy, computed tomography revealed progression of chest and abdominal wall invasion. A total dose of 70.2 Gy was delivered to both breasts, the chest wall, the abdominal wall, and the bilateral supraclavicular nodal areas in 39 fractions via HT. The total planning target volume was 4,533.29 cm3. The percent of lung volume receiving at least 20 Gy (V20 was 28%, 22%, and 25% for the right lung, left lung, and whole lung, respectively. The mean dose to the heart was 8.6 Gy. Follow-up computed tomography revealed complete response after the RT course. Grade 1 dysphagia, weight loss, grade 2 neutropenia, and grade 3 dermatitis were noted during the RT course. Pain score decreased from 6 to 1. No cardiac, pulmonary, liver, or intestinal toxicity

  8. Rogue wave variational modelling through the interaction of two solitary waves

    Science.gov (United States)

    Gidel, Floriane; Bokhove, Onno

    2016-04-01

    The extreme and unexpected characteristics of Rogue waves have made them legendary for centuries. It is only on the 1st of January 1995 that these mariners' tales started to raise scientist's curiosity, when such a wave was recorded in the North Sea; a sudden wall of water hit the Draupner offshore platform, more than twice higher than the other waves, providing evidence of the existence of rogue or freak waves. Since then, studies have shown that these surface gravity waves of high amplitude (at least twice the height of the other sea waves [Dyste et al., 2008]) appear in non-linear dispersive water motion [Drazin and Johnson, 1989], at any depth, and have caused a lot of damage in recent years [Nikolkina and Didenkulova, 2011 ]. So far, most of the studies have tried to determine their probability of occurrence, but no conclusion has been achieved yet, which means that we are currently unenable to predict or avoid these monster waves. An accurate mathematical and numerical water-wave model would enable simulation and observation of this external forcing on boats and offshore structures and hence reduce their threat. In this work, we aim to model rogue waves through a soliton splash generated by the interaction of two solitons coming from different channels at a specific angle. Kodama indeed showed that one way to produce extreme waves is through the intersection of two solitary waves, or one solitary wave and its oblique reflection on a vertical wall [Yeh, Li and Kodama, 2010 ]. While he modelled Mach reflection from Kadomtsev-Petviashvili (KP) theory, we aim to model rogue waves from the three-dimensional potential flow equations and/or their asymptotic equivalent described by Benney and Luke [Benney and Luke, 1964]. These theories have the advantage to allow wave propagation in several directions, which is not the case with KP equations. The initial solitary waves are generated by removing a sluice gate in each channel. The equations are derived through a

  9. Identifying the hotspots of non-renewable water use using HiGW-MAT: A new land surface model coupled with human interventions and ground water reservoir

    Science.gov (United States)

    Oki, T.; Pokhrel, Y. N.; Yeh, P. J.; Koirala, S.; Kanae, S.; Hanasaki, N.

    2011-12-01

    The real hydrological cycles on the Earth are not natural anymore. Global hydrological model simulations of the water cycle and available water resources should have an ability to consider the effects of human interventions on hydrological cycles. Anthropogenic activity modules (Hanasaki et al., 2008), such as reservoir operation, crop growth and water demand in crop lands, and environmental flows, were incorporated into a land surface model called MATSIRO (Takata et al., 2003), to form a new model, MAT-HI (Pokhrel et al., 2011). Total terrestrial water storages (TWS) in large river basins were estimated using the new model by off-line simulation, and compared with the TWS observed by GRACE for 2002-2007. The results showed MAT-HI has an advantage estimating TWS particularly in arid river basins compared with H08 (Hanasaki et al., 2008). MAT-HI was further coupled with a module representing the ground water level fluctuations (Yeh et al., 2005), and consists a new land surface scheme HiGW-MAT (Human Intervention and Ground Water coupled MATSIRO). HiGW-MAT is also associated with a scheme tracing the origin and flow path with the consideration on the sources of water withdrawal from stream flow, medium-size reservoirs and nonrenewable groundwater in addition to precipitation to croplands enabled the assessment of the origin of water producing major crops as Hanasaki et al. (2010). Areas highly dependent on nonrenewable groundwater are detected in the Pakistan, Bangladesh, western part of India, north and western parts of China, some regions in the Arabian Peninsula and the western part of the United States through Mexico. Cumulative nonrenewable groundwater withdrawals estimated by the model are corresponding fairly well with the country statistics of total groundwater withdrawals. Ground water table depletions in large aquifers in US estimated by HiGW-MAT were compared with in-situ observational data, and the correspondences are very good. Mean global exploitation

  10. 复合材料蜂窝夹芯板低速冲击损伤研究%Studies on Low-velocity Impact damage of Composite Honeycomb Sandwich Panel

    Institute of Scientific and Technical Information of China (English)

    李进亚; 许希武; 毛春见

    2012-01-01

    A 3D dynamic finite element model is proposed to predict the progressive damage of composites honeycomb core sandwich due to low impact. The core of this model was equivalent to a uniform orthogonal anisotropic materials. This model consists of Hashin damage criterion and Yeh failure criterion for face-plate, and deg-radate the material property which is damaged. Combined with the user-defined material constitutive program of Abaqus , the failure criterion and degra dation of material property are simulated . The dynamic response and dam-age propagation of comp osites honeycomb core sandwich due to low impact were simulated with this method. The numerical results is compared with the experiment results, it prove that the method was reasonable. The effects of the parameters on the dynamic response and damage evolution of composites honeycomb core sandwich are discussed in this paper.%通过三维动力学有限元建立了复合材料蜂窝夹芯板在低速冲击作用下的渐进损伤分析模型.该模型中将蜂窝夹芯等效为均匀的正交各项异性材料.采用基于应变的Hashin三维失效准则和Yeh分层失效准则对面板损伤进行判断.使用部分刚度折减对损伤材料性能进行退化.利用用户子程序将损伤判据和刚度折减方案引入到ABAQUS软件中.模拟了复合材料蜂窝夹芯板低速冲击损伤渐进过程,并与试验结果进行验证.证明了该方法的合理性,最后讨论了各种参数对冲击响应和冲击损伤的影响.

  11. Intracerebroventricular urocortin 3 counteracts central acyl ghrelin-induced hyperphagic and gastroprokinetic effects via CRF receptor 2 in rats

    Directory of Open Access Journals (Sweden)

    Yeh C

    2016-10-01

    Full Text Available Chun Yeh,1 Ching-Heng Ting,2 Ming-Luen Doong,3 Chin-Wen Chi,4,5 Shou-Dong Lee,1 Chih-Yen Chen6–8 1Division of Gastroenterology, Department of Internal Medicine, Cheng-Hsin General Hospital, 2Department of Pathology, Mackay Memorial Hospital, 3Institute of Physiology, 4Institute of Pharmacology, National Yang-Ming University School of Medicine, 5Department of Medical Research, Taipei Veterans General Hospital, 6Division of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, 7Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei, 8Taiwan Association for the Study of Small Intestinal Diseases, Guishan, Taiwan Purpose: Urocortin 3 is a key neuromodulator in the regulation of stress, anxiety, food intake, gut motility, and energy homeostasis, while ghrelin elicits feeding behavior and enhances gastric emptying, adiposity, and positive energy balance. However, the interplays between urocortin 3 and ghrelin on food intake and gastric emptying remain uninvestigated.Methods: We examined the differential effects of central O-n-octanoylated ghrelin, des-Gln14-ghrelin, and urocortin 3 on food intake, as well as on charcoal nonnutrient semiliquid gastric emptying in conscious rats that were chronically implanted with intracerebroventricular (ICV catheters. The functional importance of corticotropin-releasing factor (CRF receptor 2 in urocortin 3-induced responses was examined by ICV injection of the selective CRF receptor 2 antagonist, astressin2-B.Results: ICV infusion of urocortin 3 opposed central acyl ghrelin-elicited hyperphagia via CRF receptor 2 in satiated rats. ICV injection of O-n-octanoylated ghrelin and des-Gln14-ghrelin were equally potent in accelerating gastric emptying in fasted rats, whereas ICV administration of urocortin 3 delayed gastric emptying. In addition, ICV infusion of urocortin 3 counteracted central acyl ghrelin-induced gastroprokinetic effects via CRF receptor 2

  12. Colossal dielectric constant in high entropy oxides

    Energy Technology Data Exchange (ETDEWEB)

    Berardan, David; Franger, Sylvain; Dragoe, Diana; Meena, Arun Kumar; Dragoe, Nita [ICMMO (UMR 8182 CNRS), Universite Paris-Sud, Universite Paris-Saclay, 91405, Orsay (France)

    2016-04-15

    Entropic contributions to the stability of solids are very well understood and the mixing entropy has been used for forming various solids, for instance such as inverse spinels, see Nawrotsky et al., J. Inorg. Nucl. Chem. 29, 2701 (1967) [1]. A particular development was related to high entropy alloys by Yeh et al., Adv. Eng. Mater. 6, 299 (2004) [2] and Cantor et al., Mater. Sci. Eng. A 375-377, 213 (2004) [3] (for recent reviews see Zhang et al., Prog. Mater. Sci. 61, 1 (2014) [4] and Tsai et al., Mater. Res. Lett. 2, 107 (2014) [5]) in which the configurational disorder is responsible for forming simple solid solutions and which are thoroughly studied for various applications especially due to their mechanical properties, e.g. Gludovatz et al., Science 345, 1153 (2014) [6] and Lu et al., Sci. Rep. 4, 6200 (2014) [7], but also electrical properties, Kozelj et al., Phys. Rev. Lett. 113, 107001 (2014) [8], hydrogen storage, Kao et al., Int. J. Hydrogen Energy 35, 9046 (2010) [9], magnetic properties, Zhang et al., Sci. Rep. 3, 1455 (2013) [10]. Many unexplored compositions and properties still remain for this class of materials due to their large phase space. In a recent report it has been shown that the configurational disorder can be used for stabilizing simple solid solutions of oxides, which should normally not form solid solutions, see Rost et al., Nature Commun. 6, 8485 (2015) [11] these new materials were called ''entropy-stabilized oxides''. In this pioneering report, it was shown that mixing five equimolar binary oxides yielded, after heating at high temperature and quenching, an unexpected rock salt structure compound with statistical distribution of the cations in a face centered cubic lattice. Following this seminal study, we show here that these high entropy oxides (named HEOx hereafter) can be substituted by aliovalent elements with a charge compensation mechanism. This possibility largely increases the potential development of new

  13. Secondary glaucoma in CAPN5-associated neovascular inflammatory vitreoretinopathy

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    Cham A

    2016-06-01

    Full Text Available Abdourahman Cham,1,2 Mayank Bansal,3 Himanshu K Banda,4 Young Kwon,1 Paul S Tlucek,1 Alexander G Bassuk,5 Stephen H Tsang,6,7 Warren M Sobol,8 James C Folk,1 Steven Yeh,4 Vinit B Mahajan1,2 1Department of Ophthalmology and Visual Sciences, 2Omics Laboratory, University of Iowa, Iowa City, IA, USA; 3Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India; 4Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA, 5Department of Pediatrics, University of Iowa, Iowa City, IA, 6Barbara and Donald Jonas Laboratory of Stem Cells and Regenerative Medicine and Bernard and Shirlee Brown Glaucoma Laboratory, Department of Pathology and Cell Biology, Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, 7Edward S Harkness Eye Institute, New York-Presbyterian Hospital, New York, NY, 8Retina Physicians & Surgeons, Inc., Dayton, OH, USA Objective: The objective of this study was to review the treatment outcomes of patients with secondary glaucoma in cases of autosomal dominant neovascular inflammatory vitreoretinopathy (ADNIV, a hereditary autoimmune uveitis due to mutations in CAPN5. Patients and methods: A retrospective, observational case series was assembled from ADNIV patients with secondary glaucoma. The main outcome measures were intraocular pressure (IOP, visual acuity, use of antiglaucoma medications, ocular surgeries, and adverse outcomes. Perimetry and optic disk optical coherence tomography (OCT were also analyzed. Results: Nine eyes of five ADNIV patients with secondary glaucoma were reviewed. Each received a fluocinolone acetonide (FA implant for the management of posterior uveitis. Following implantation, no eyes developed neovascular glaucoma. Five eyes (in patients 1, 2, and 5 required Ahmed glaucoma valve surgery for the management of steroid-responsive glaucoma. Patient 2 also developed angle closure with iris bombe and underwent laser

  14. Virtual Impactor for Sub-micron Aerosol Particles

    Science.gov (United States)

    Bolshakov, A. A.; Strawa, A. W.; Hallar, A. G.

    2005-12-01

    , B.A. Paldus, J. Atm. Ocean. Technol., 20, 454-465 (2003). 2. V.A. Marple, K.L. Rubow, B.A. Olson, Aerosol Sci. Technol., 22, 140-150 (1995). 3. B.T. Chen, H.C. Yeh, Y.S. Cheng, J. Aerosol Sci., 16, 343-354 (1985). 4. V.A. Marple, C.M. Chien, Environ. Sci. Technol., 14, 976-985 (1980).

  15. Hannibal Rosselli - professor of the Cracov Academy and author of "Pymander"

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    Wiesław Murawiec

    1989-12-01

    ; der Band V - dem polnischen König Stefan Batory; der Band VI /u.d.T. "Asclepius"/ - dem Erzbischof von Lemberg, Dan Dimitrij Solikowski; der Band IX - dem Kanonikus am Krakauer Dom Hieronymus Powodowski. Die übrigen fehlenden Bände /VII, VIII und X/ waren zwar druckfertig, erschienen jedoch nicht, auch die Manuskripte gingen verloren. Die ersten sechs Bände des "Pymander1’ erschienen dann noch einmal 1630 in Köln .in der Offizin des P. Cholinius, mitredigiert von F. Foix de Candal, einem klassischen Philologen. Rosselli stand in seiner Versöhnungsbereitschaft gegenüber anderen Konfessionen Erasmus von Rotterdam sehr nahe. Dennoch stiess er in Krakau auf keinen Widerstand, weder seitens seiner Mitbrüder noch seitens der Krakauer Professoren. Seine Widersacher, wie z.B. Podwodowski oder der Rektor der Universität, Jakub Görski, teilten zwar seine Einstellung nicht, begegnetem ihm aber stets mit grösser Freundlichkeit. Nicht ohne Bedeutung dürfte dabei der Umstand gewesen sein, dass Rosselli im Auftrag des Generalministers der Observanten nach Polen gekommen war und 1585 zum Generalkommissar und Visitator der polnischen Provinz zur Durchführung der tridentinischen Reform ernannt wurde. Im Bereich des Provinzkapitel in Warschau wurde 1585 eine Neuordnung des Studiums beschlossen und mit dem Lehrauf - trag jene Ordensbrüder betraut, die ihr Theologiestudium in Wilna abgeschlossen hatten. Rosselli machte sich einen Namen auch als Prediger. Zwei seiner Predigten sind uns in schriftlicher Form erhalten geblieben, die eine als Manuskript über die Auferstehung Christi aus dem Jahre 1582 /Ossolineum- Bibliothek, Hnds. 229, S. 123-129/, die andere wurde 1590 in Krakau u.d.T. "Oratio fuebralis ... in sepultra Stephani I Regis Poloniae. 1586" veröffentlicht. Die letztere hielt er bei der Bestattungszeremonie des polnischen Königs Bathory. Er soll auch bei der Krönung des Königs Sigismund III Waza gepredigt haben. Aus seiner Feder stammten weiters die uns heute

  16. MART-10, a newly synthesized vitamin D analog, represses metastatic potential of head and neck squamous carcinoma cells

    Directory of Open Access Journals (Sweden)

    Yang SW

    2016-06-01

    Full Text Available Shih-Wei Yang,1,* Chi-Ying Tsai,2,* Yi-Chun Pan,3 Chun-Nan Yeh,4 Jong-Hwei S Pang,5 Masashi Takano,6 Atsushi Kittaka,6 Horng-Heng Juang,7 Tai C Chen,8 Kun-Chun Chiang4,9 1Department of Otolaryngology – Head and Neck Surgery, Chang Gung Memorial Hospital, Keelung, 2Department of Oral and Maxillofacial Surgery, Chang Gung Memorial Hospital, Taoyuan, 3Department of General Dentistry, Chang Gung Memorial Hospital, Chang Gung University, Keelung, 4General Surgery Department, Chang Gung Memorial Hospital, Keelung, 5Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan, Republic of China; 6Faculty of Pharmaceutical Sciences, Teikyo University, Tokyo, Japan; 7Department of Anatomy, College of Medicine, Chang Gung University, Taoyuan, Taiwan, Republic of China; 8Endocrine Core Laboratory, Boston University School of Medicine, Boston, MA, USA; 9Zebrafish Center, Chang Gung Memorial Hospital, Keelung, Taiwan, Republic of China *These authors contributed equally to this work Abstract: Even with multidisciplinary treatment, the prognosis and quality of life of patients diagnosed with head and neck squamous cell carcinoma (HNSCC are still not satisfactory. Previously, 19-Nor-2α-(3-hydroxypropyl-1α,25(OH2D3 (MART-10, the new brand 1α,25(OH2D3 analog, has been demonstrated to be an effective drug to inhibit HNSCC growth in vitro. Since most cancer patients die of metastasis, in this study, the antimetastatic effect of MART-10 on HNSCC was investigated. Our results reveal that both 1α,25(OH2D3 and MART-10 effectively repressed the migration and invasion of HNSCC cells, with MART-10 being much more potent than 1α,25(OH2D3. The antimetastatic effect of 1α,25(OH2D3 and MART-10 was mediated by attenuation of epithelial–mesenchymal transition (EMT, which was supported by the finding that the expression of EMT-inducing transcriptional factors, Sail and Twist, was inhibited by 1α,25(OH2D3 and MART

  17. Atmospheric circulation remote response during two types of El Niño in changing climate

    Science.gov (United States)

    Zheleznova, Irina

    2017-04-01

    Germany: Germany, 2016. — P. EGU2016-235-2. 3. Weng H., Behera S. K. and Yamagata T. Anomalous winter climate conditions in the Pacific Rim during recent El Nino Modoki and El Nino events. - Clim. Dyn., 2009, vol. 32, pp. 663-674. 4. Yeh, S.-W., S.-J. Kug, B. Dewitte,M.-H. Kwon, B. P. Kirtman, and F.-F. Jin, 2009: El Niño in a changing climate. Nature, 461, 511-514. 5. Zheleznova I. V., Gushchina D. Y. The response of global atmospheric circulation to two types of El Niño // Russian Meteorology and Hydrology. — 2015. — Vol. 40, no. 3. — P. 170-179. 6. Zheleznova I. V., Gushchina D. Y. Circulation anomalies in the atmospheric centers of action during the eastern pacific and central pacific El Nino // Russian Meteorology and Hydrology. — 2016. — Vol. 41, no. 11-12. — P. 760-769. 7. Zheleznova I. V., Gushchina D. Y. , Matveeva T.A. Remote response on the two types of el niño in coupled model intercomparison project phase 5 models // 33 International Geographical Congress : Book of Abstracts. — Beijing, China, 2016.

  18. Alternative theories of atmospheric telecommunications and low-frequency fluctuations

    Science.gov (United States)

    Frederiksen, Jorgen S.; Webster, Peter J.

    1988-08-01

    Observational studies have revealed a rich low-frequency structure in the atmosphere. A review of the theories, observations, and model studies of this low-frequency atmospheric variability is presented. On time scales of weeks or longer the atmosphere appears to possess distinct oscillatory behavior in well-defined and persistent "centers of action." This behavior is also an endemic feature of surrogate atmospheric data sets emerging from experiments with complicated climate models. Many theories have attempted to determine the dominant physical processes responsible for the low-frequency variance but have usually failed when compared carefully with observations. For example, simple linear steady state and Rossby wave dispersion theories have been used in an attempt to explain the observed global response to low-latitude perturbation. However, the observed structures of mature anomalies are often quite distinct from the vertical structures of disturbances predicted in these theories. Also, in general circulation and model studies, the sign of the nonlinear response is not simply related to the sign of the forcing as predicted by linear steady state theories. It is argued that the theories fail because either the full three-dimensional complexity of the basic state is not considered or its inherent instability structure is not recognized or is, in fact, ignored. It is shown that three-dimensional instability theory provides a natural generalization and marriage of the zonally averaged instability theory of Charney and Eady and the Rossby wave dispersion theory of Rossby and Yeh. As such, it provides a formalism which may be used to understand a wide variety of atmospheric fluctuations including the locations of eddy flux covariance maxima and storm tracks in both the tropics and extratropics and the generation of blocking, teleconnection patterns, and other quasi-stationary anomaly features. Attention is focused on two particular mechanisms within this formalism

  19. Development of Yersinia pestis F1 antigen-loaded microspheres vaccine against plague

    Directory of Open Access Journals (Sweden)

    Huang SS

    2014-02-01

    Full Text Available Shih-shiung Huang,1 I-Hsun Li,2,3 Po-da Hong,1 Ming-kung Yeh1,2,41Biomedical Engineering Program, Graduate Institute of Engineering, Department of Materials Science and Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan, Republic of China; 2School of Pharmacy, 3Department of Pharmacy Practice, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China; 4Food and Drug Administration, Ministry of Health and Welfare, Taipei, Taiwan, Republic of ChinaAbstract: Yersinia pestis F1 antigen-loaded poly(DL-lactide-co-glycolide/polyethylene glycol (PEG (PLGA/PEG microspheres were produced using a water-in-oil-in-water emulsion/solvent extraction technique and assayed for their percent yield, entrapment efficiency, surface morphology, particle size, zeta potential, in vitro release properties, and in vivo animal protect efficacy. The Y. pestis F1 antigen-loaded microspheres (mean particle size 3.8 µm exhibited a high loading capacity (4.5% w/w, yield (85.2%, and entrapment efficiency (38.1%, and presented a controlled in vitro release profile with a low initial burst (18.5%, then continued to release Y. pestis F1 antigen over 70 days. The distribution (% of Y. pestis F1 on the microspheres surface, outer layer, and core was 3.1%, 28.9%, and 60.7%, respectively. A steady release rate was noticed to be 0.55 µg Y. pestis F1 antigen/mg microspheres/day of Y. pestis F1 antigen release maintained for 42 days. The cumulative release amount at the 1st, 28th, and 42nd days was 8.2, 26.7, and 31.0 µg Y. pestis F1 antigen/mg microspheres, respectively. The 100 times median lethal dose 50% (LD50 of Y. pestis Yokohama-R strain by intraperitoneal injection challenge in mice test, in which mice received one dose of 40 µg F1 antigen content of PLGA/PEG microspheres, F1 antigen in Al(OH3, and in comparison with F1 antigen in Al(OH3 vaccine in two doses, was evaluated after given by subcutaneous

  20. Evaluation of protective efficacy using a nonstructural protein NS1 in DNA vaccine–loaded microspheres against dengue 2 virus

    Directory of Open Access Journals (Sweden)

    Huang SS

    2013-08-01

    Full Text Available Shih-shiung Huang,1 I-Hsun Li,2,3 Po-da Hong,1 Ming-kung Yeh1,2 1Biomedical Engineering Program, Graduate Institute of Applied Science and Technology, and Department of Materials Science and Engineering, National Taiwan University of Science and Technology, Taiwan; 2School of Pharmacy, National Defence Medical Center and Bureau of Pharmaceutical Affairs, Military of National Defence Medical Affairs Bureau, Taipei, Taiwan; 3Department of Pharmacy Practice, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan Abstract: Dengue virus results in dengue fever or severe dengue hemorrhagic fever/dengue shock syndrome in humans. The purpose of this work was to develop an effective antidengue virus delivery system, by designing poly (dl-lactic-co-glycolic acid/polyethylene glycol (PLGA/PEG microspheres using a double-emulsion solvent extraction method, for vaccination therapy based on locally and continuously sustained biological activity. Nonstructural protein 1 (NS1 in deoxyribonucleic acid (DNA vaccine–loaded PLGA/PEG microspheres exhibited a high loading capacity (4.5% w/w, yield (85.2%, and entrapment efficiency (39%, the mean particle size 4.8 µm, and a controlled in vitro release profile with a low initial burst (18.5%, lag time (4 days, and continued released protein over 70 days. The distribution of protein on the microspheres surface, outer layer, and core were 3.0%, 28.5%, and 60.7%, respectively. A release rate was noticed to be 1.07 µg protein/mg microspheres/day of protein release, maintained for 42 days. The cumulative release amount at Days 1, 28, and 42 was 18.5, 53.7, and 62.66 µg protein/mg microspheres, respectively. The dengue virus challenge in mice test, in which mice received one dose of 20 µg NS1 protein content of microspheres, in comparison with NS1 protein in Al(OH3 or PBS solution, was evaluated after intramuscular immunization of BALB/c mice. The study results show that the greatest survival was

  1. Increased risk of pernicious anemia following scabies: a nationwide population-based matched-cohort study

    Directory of Open Access Journals (Sweden)

    Liu JM

    2017-09-01

    Full Text Available Jui-Ming Liu,1–3,* Ren-Jun Hsu,3–5,* Fung-Wei Chang,6 Feng-Hsiang Chiu,7,8 Chia-Lun Yeh,1 Chun-Fa Huang,9,10 Shu-Ting Chang,11 Hung-Chang Lee,12 Hsin Chi,12,13 Chien-Yu Lin14,15 1Division of Urology, Department of Surgery, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, 2Department of Medicine, National Yang-Ming University, 3Graduate Institute of Life Sciences, 4Department of Pathology and Graduate Institute of Pathology and Parasitology, the Tri-Service General Hospital, National Defense Medical Center, 5Biobank Management Center of the Tri-Service General Hospital, 6Department of Obstetrics and Gynecology, Tri-Service General Hospital, National Defense Medical Center, Taipei, 7Department of Emergency Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan; 8Superintendent office, Lihuili Eastern Hospital, Ningbo, Zhejiang province, People’s Republic of China; 9School of Chinese Medicine, College of Chinese Medicine, China Medical University, 10Department of Nursing, College of Medical and Health Science, Asia University, Taichung City, 11Department of Gastroenterology, BinKun Women’s and Children’s Hospital, Taoyuan City, 12Department of Infectious Disease, MacKay Children’s Hospital, Taipei, 13Department of Medicine, MacKay Medical College, New Taipei city, 14Department of Pediatrics and Infectious Disease, Hsinchu MacKay Memorial Hospital, Hsinchu City, Taiwan; 15Division of Infection and Pathway Medicine, College of Medicine and Veterinary Medicine, The University of Edinburgh, Scotland, UK *These authors contributed equally to this work Objectives: Scabies is a common and annoying disorder. Pernicious anemia (PA is a serious disease which, when untreated, leads to death. Mounting evidence suggests that immune-mediated inflammatory processes play a role in the pathophysiology of both diseases. The relationship between these two diseases has not been investigated. We conducted this

  2. Final Scientific/Technical Report – DE-FG02-06ER64172 – Reaction-Based Reactive Transport Modeling of Iron Reduction and Uranium Immobilization at Area 2 of the NABIR Field Research Center – Subproject to Co-PI Eric E. Roden

    Energy Technology Data Exchange (ETDEWEB)

    Eric E. Roden

    2009-03-17

    This report summarizes research conducted in conjunction with a project entitled “Reaction-Based Reactive Transport Modeling of Iron Reduction and Uranium Immobilization at Area 2 of the NABIR Field Research Center”, which was funded through the Integrative Studies Element of the former NABIR Program (now the Environmental Remediation Sciences Program) within the Office of Biological and Environmental Research. Dr. William Burgos (The Pennsylvania State University) was the overall PI/PD for the project, which included Brian Dempsey (Penn State), Gour-Tsyh (George) Yeh (Central Florida University), and Eric Roden (formerly at The University of Alabama, now at the University of Wisconsin) as separately-funded co-PIs. The project focused on development of a mechanistic understanding and quantitative models of coupled Fe(III)/U(VI) reduction in FRC Area 2 sediments. The work builds on our previous studies of microbial Fe(III) and U(VI) reduction, and was directly aligned with the Scheibe et al. ORNL FRC Field Project at Area 2. Area 2 is a shallow pathway for migration of contaminated groundwater to seeps in the upper reach of Bear Creek at ORNL, mainly through a ca. 1 m thick layer of gravel located 4-5 m below the ground surface. The gravel layer is sandwiched between an overlying layer of disturbed fill material, and 2-3 m of undisturbed shale saprolite derived from the underlying Nolichucky Shale bedrock. The fill was put in place when contaminated soils were excavated and replaced by native saprolite from an uncontaminated area within Bear Creek Valley; the gravel layer was presumably installed prior to addition of the fill in order to provide a stable surface for the operation of heavy machinery. The undisturbed saprolite is highly weathered bedrock that has unconsolidated character but retains much of the bedding and fracture structure of the parent rock (shale with interbedded limestone). Hydrological tracer studies conducted during the Scheibe et al. field

  3. How can coastal parks contain the destructive impact of a tsunami? A numerical approach to the understanding of tsunami-triggered waves in the presence of coastal hills

    Science.gov (United States)

    Marras, Simone; Suckale, Jenny; Lunghino, Brent; Giraldo, Francis X.; Constantinescu, Emil

    2016-04-01

    reducing it. Nevertheless, without a thorough understanding of the behavior of non-linear waves when they approach coastal configurations such as hills, coastal parks may still be far from a safe reality. References [1] P. Lynett (2007) "Effect of shallow water obstruction on long wave run-up and overland flow velocity" J. Waterway, Port, Coastal, Ocean Engrg. 136:455-462 [2] G. F. Carrier, T. T. Wu, H. Yeh (2003) "Tsunami run-up and draw-down on a plane beach" J. Fluid Mech. 475:79-99. [3] F. X. Giraldo and M. Restelli (2010) "High-order semi- implicit time-integrators for a triangular discontinuous Galerkin oceanic shallow water model" Int. J. Numer. Methods Fluids, 63:1077-1102. [4] F X. Giraldo, J F.. Kelly, and E. Constantinescu. "Implicit-explicit formulations of a three-dimensional Nonhydrostatic Unified Model of the Atmosphere (NUMA)" SIAM J. Sci. Comput., 35:1162-1194, 2013.

  4. How to upscale the coupling between hydrology and vegetation at the hillslope scale with an equivalent soil-vegetation column model

    Science.gov (United States)

    Maquin, Mathilde; Mugler, Claude; Mouche, Emmanuel; Ducharne, Agnès

    2014-05-01

    term is added to Richards' equation at the bottom of the column to model groundwater discharge to streams. Contrary to what has already been proposed (Liang et al., Journal of Geophysical Research, 1994; Yeh and Eltahir, Journal of Climate, 2005; Niu et al., Journal of Geophysical Research, 2007), this sink term is deduced from Darcy's law and Van Genuchten's relationships. Through the approximation of a linear groundwater table profile in two dimensions, a differential equation of the water table depth at a fixed distance from the river has been determined. It depends on topographic and soil parameters, and on the distance between the stream and the modelled column. Different types of soil and climate forcing (especially precipitations) have been tested in the above framework. Comparisons between the 2D reference model and a few 1D columns show good agreement in water table depth and evapotranspiration fluxes. This justifies using an equivalent column to replace the set of independent columns, with respect to evapotranspiration fluxes.

  5. [Predictive factors in social adaptation disorders in anorexic and bulimic patients].

    Science.gov (United States)

    Godart, N T; Flament, M F; Perdereau, F; Jeammet, P

    2003-01-01

    A lifetime diagnosis of at least one anxiety disorder has been found in 13% to 75% of women with BN (Herzog, Keller, Sacks, Yeh, & Lavori, 1992; Schwalberg, Barlow, Alger, & Howard, 1992), and in 20% to 55% of women with AN, (Herzog et al., 1992, Laessle et al., 1989). Wittchen et al., 1998) have observed that the frequency and degree of disabilities and impairments associated with mental disorders in adolescence are strongly related to comorbidity (notably with anxiety disorders). However, as noted by Wonderlich et al., 1997, no study has compared ED individuals with and without comorbid anxiety disorders in terms of clinical or general functioning. The current study was designed to determine whether social avoidance symptoms and/or comorbid lifetime anxiety disorders were predictive factors of social disability in subjects with ED (AN or BN). We focused on two main dimensions of social adaptation, regarding social and professional life. 63 subjects with anorexia nervosa or bulimia nervosa were assessed for lifetime diagnoses of anxiety disorders, childhood history of separation anxiety disorder, social avoidance symptoms, and social disability. Sociodemographic characteristics, lifetime diagnoses of ED and anxiety disorders, and ages at onset of each disorder present, were assessed using the French version of the Composite International Diagnostic Interview (CIDI) (Robins et al., 1988; WHO, 1990). In addition, childhood history of separation anxiety disorder, not included in the CIDI, was assessed using the appropriate section of the Schedule for Schizophrenia and Affective Disorders Lifetime Version--Modified for the study of Anxiety Disorders (SADS-LA-R) (Endicott, Spitzer, 1978; Mannuzza, Fyer, Klein, 1985). Social anxiety symptoms were measured on Liebowitz Social Phobia Scale (Liebowitz, 1987). Social adjustment was assessed using a semi-structured interview, the Groningen Social Disabilities Schedule-Second version (GSDS-II) (Wiersma, De Jong, Ormel

  6. PLGA nanoparticles codeliver paclitaxel and Stat3 siRNA to overcome cellular resistance in lung cancer cells

    Directory of Open Access Journals (Sweden)

    Su WP

    2012-08-01

    Full Text Available Wen-Pin Su,1,2 Fong-Yu Cheng,3 Dar-Bin Shieh,3–6 Chen-Sheng Yeh,5–7 Wu-Chou Su1,2,81Graduate Institute of Clinical Medicine, College of Medicine, National Cheng Kung University; 2Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University; 3Institute of Oral Medicine, College of Medicine, National Cheng Kung University; 4Department of Stomatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University; 5Advanced Optoelectronic Technology Center; 6Center for Frontier Materials and Micro/Nano Science and Technology, and 7Department of Chemistry, National Cheng Kung University; 8Cancer Center, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.Abstract: Background: Effective cancer chemotherapy remains an important issue in cancer treatment, and signal transducer and activator of transcription-3 (Stat3 activation leads to cellular resistance of anticancer agents. Polymers are ideal vectors to carry both chemotherapeutics and small interfering ribonucleic acid (siRNA to enhance antitumor efficacy. In this paper, poly(lactic-co-glycolic acid (PLGA nanoparticles loaded with paclitaxel and Stat3 siRNA were successfully synthesized, and their applications in cancer cells were investigated.Methods: Firstly, paclitaxel was enclosed by PLGA nanoparticles through solvent evaporation. They were then coated with cationic polyethylenimine polymer (PLGA-PEI-TAX, enabling it to carry Stat3 siRNA on its surface through electrostatic interactions (PLGA-PEI-TAX-S3SI. The size, zeta potential, deliver efficacy, and release profile of the PLGA nanocomplexes were characterized in vitro. The cellular uptake, intracellular nanoparticle trajectory, and subsequent cellular events were evaluated after treatment with various PLGA nanocomplexes in human lung cancer A549 cells and A549-derived paclitaxel

  7. Design of acid-responsive polymeric nanoparticles for 7,3',4'-trihydroxyisoflavone topical administration

    Directory of Open Access Journals (Sweden)

    Huang PH

    2016-04-01

    Full Text Available Pao-Hsien Huang,1,* Stephen Chu-Sung Hu,2,3,* Chiang-Wen Lee,4,5 An-Chi Yeh,6 Chih-Hua Tseng,7 Feng-Lin Yen1,8,9 1Department of Fragrance and Cosmetic Science, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, 2Department of Dermatology, College of Medicine, Kaohsiung Medical University, Kaohsiung, 3Department of Dermatology, Kaohsiung Medical University Hospital, Kaohsiung, 4Research Center for Industry of Human Ecology, Chang Gung University of Science and Technology, Kweishan, Taoyuan, 5Department of Nursing, Division of Basic Medical Sciences, Chang Gung University of Science and Technology, Chia-Yi, 6Department of Cosmetics and Fashion Styling, Cheng Shiu University, Kaohsiung, 7School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, 8Lipid Science and Aging Research Center, Kaohsiung Medical University, Kaohsiung, 9Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan *These authors contributed equally to this work Abstract: 7,3',4'-Trihydroxyisoflavone (734THIF is a secondary metabolite of daidzein and has been recently found to possess antioxidant, melanin inhibition, and skin cancer chemopreventive activities. However, the poor water solubility of 734THIF impedes its absorption and skin penetration and, therefore, limits its pharmacological effects when applied topically to the skin. We seek to use the nanoprecipitation method to prepare optimal eudragit E100 (EE–polyvinyl alcohol (PVA-loaded 734THIF nanoparticles (734N to improve its physicochemical properties and thereby increase its water solubility, skin penetration, and biological activities. EE–PVA-loaded 734THIF nanoparticles (734N were prepared, and their morphology and particle size were evaluated using a particle size analyzer and by electron microscopy. The drug loading and encapsulation efficiencies and in vitro solubility were determined using high-performance liquid chromatography. Hydrogen

  8. Fluid-rock interaction: A reactive transport approach

    Energy Technology Data Exchange (ETDEWEB)

    Steefel, C.; Maher, K.

    2009-04-01

    irreversible. Helgeson's pioneering approach was given a more formal kinetic basis (including the introduction of real time rather than reaction progress as the independent variable) in subsequent studies (Lasaga 1981; Aagaard and Helgeson 1982; Lasaga 1984). The reaction path approach can be used to describe chemical processes in a batch or closed system (e.g., a laboratory beaker), but such systems are of limited interest in the Earth sciences where the driving force for most reactions is transport. Lichtner (1988) clarified the application of the reaction path models to water-rock interaction involving transport by demonstrating that they could be used to describe pure advective transport through porous media. By adopting a reference frame which followed the fluid packet as it moved through the medium, the reaction progress variable could be thought of as travel time instead. Multi-component reactive transport models that could treat any combination of transport and biogeochemical processes date back to the early 1980s. Berner and his students applied continuum reactive transport models to describe processes taking place during the early diagenesis of marine sediments (Berner 1980). Lichtner (1985) outlined much of the basic theory for a continuum model for multicomponent reactive transport. Yeh and Tripathi (1989) also presented the theoretical and numerical basis for the treatment of reactive contaminant transport. Steefel and Lasaga (1994) presented a reactive flow and transport model for nonisothermal, kinetically-controlled water-rock interaction and fracture sealing in hydrothermal systems based on simultaneous numerical solution of both reaction and transport This chapter begins with a review of the important transport processes that affect or even control fluid-rock interaction. This is followed by a general introduction to the governing equations for reactive transport, which are broadly applicable to both qualitative and quantitative interpretations of fluid

  9. Physical Hydraulic Model of Side-Channel Spillway of Lambuk DAM, Bali

    Science.gov (United States)

    Harifa, A. C.; Sholichin, M.; Othman, F. B.

    2013-12-01

    The spillway is among the most important structures of a dam project. A spillway is designed to prevent overtopping of a dam at a place that is not designed for overtopping. Side-channel spillways are commonly used to release water flow from a reservoir in places where the sides are steep and have a considerable height above the dam. Experimental results were collected with a hydraulic model of the side-channel spillway for releasing the peak overflow of Lambuk Dam. This dam is, located on the Lambuk River, which is a tributary of the Yeh Hoo River ~ 34.6 km north of Denpasar on the island of Bali. The bituminous geomembrane faced dam is 24 m in height, with a 35-m wide spillway. The length of the side channel is 35 m long, with 58 m of transition channel, 67.37 m of chuteway channel and 22.71 m of stilling basin. The capacity of the spillway is 231.91 m3/s and the outlet works capacity is 165.28 m3/s. The reservoir is designed for irrigation and water supply. The purpose of this study was to optimize the designed of the structure and to ensure its safe operation. In hydraulic model may help the decision-makers to visualize the flow field before selecting a ';suitable' design. The hydraulic model study was performed to ensure passage of the maximum discharge at maximum reservoir capacity; to study the spillway approach conditions, water surface profiles, and flow patterns in the chuteway; and to reveal potential demerits of the proposed hydraulic design of various structures and explore solutions. The model was constructed at 1 : 40 scale, Reservoir topography was modeled using concrete, the river bed using sand and some gravel, the river berm using concrete, and the spillway and channel using Plexiglas. Water was measured using Rectangular contracted weir. Design floods (with return period in year) were Q2 = 111.40 m3/s, Q5 = 136.84 m3/s, Q10 = 159.32 m3/s, Q25 = 174.61 m3/s, Q50 = 185.13 m3/s, Q100 = 198.08 m3/s, Q200 = 210.55 m3/s, Q1000 = 231.91 m3/s and the

  10. Model reduction in coupled groundwater-surface water systems - potentials and limitations of the applied proper orthogonal decomposition (POD) method

    Science.gov (United States)

    Gosses, Moritz; Moore, Catherine; Wöhling, Thomas

    2016-04-01

    . The subspace is generated by sampling full-model variation via snapshots in time, which requires only a few runs of the complex model. In theory, straight-forward POD methods are only applicable to linear problems. To test the limits of the POD method, we apply it to a complex non-linear synthetic groundwater model using MODFLOW and compare the loss of model accuracy to the accuracy of the complex model. Success of the applied POD method is evaluated by estimating the tradeoff between reduction of computing times and the deterioration of simulation accuracy. Preliminary results have shown that run time reductions of two orders of magnitude are possible while retaining acceptable precision levels. References: Doherty, J. and Christensen, S. (2011). Use of paired simple and complex models to reduce predictive bias and quantify uncertainty. Water Resour. Res., 47(12):W12534. Sahuquillo, A. (1983). An eigenvalue numerical technique for solving un-steady linear groundwater models continuously in time. Water Resour. Res.,19(1):87-93. Siade, A. J., Putti, M., and Yeh, W. W.-G. (2010). Snapshot selection for groundwater model reduction using proper orthogonal decomposition. Water Resour. Res., 46(8):W08539.

  11. Mössbauer characterization of an unusual high-spin side-on peroxo-Fe3+ species in the active site of superoxide reductase from Desulfoarculus Baarsii. Density functional calculations on related models.

    Science.gov (United States)

    Horner, Olivier; Mouesca, Jean-Marie; Oddou, Jean-Louis; Jeandey, Claudine; Nivière, Vincent; Mattioli, Tony A; Mathé, Christelle; Fontecave, Marc; Maldivi, Pascale; Bonville, Pierre; Halfen, Jason A; Latour, Jean-Marc

    2004-07-13

    Superoxide reductase (SOR) is an Fe protein that catalyzes the reduction of superoxide to give H(2)O(2). Recently, the mutation of the Glu47 residue into alanine (E47A) in the active site of SOR from Desulfoarculus baarsii has allowed the stabilization of an iron-peroxo species when quickly reacted with H(2)O(2) [Mathé et al. (2002) J. Am. Chem. Soc. 124, 4966-4967]. To further investigate this non-heme peroxo-iron species, we have carried out a Mössbauer study of the (57)Fe-enriched E47A SOR from D. baarsii reacted quickly with H(2)O(2). Considering the Mössbauer data, we conclude, in conjunction with the other spectroscopic data available and with the results of density functional calculations on related models, that this species corresponds to a high-spin side-on peroxo-Fe(3+) complex. This is one of the first examples of such a species in a biological system for which Mössbauer parameters are now available: delta(/Fe) = 0.54 (1) mm/s, DeltaE(Q) = -0.80 (5) mm/s, and the asymmetry parameter eta = 0.60 (5) mm/s. The Mössbauer and spin Hamiltonian parameters have been evaluated on a model from the side-on peroxo complex (model 2) issued from the oxidized iron center in SOR from Pyrococcus furiosus, for which structural data are available in the literature [Yeh et al. (2000) Biochemistry 39, 2499-2508]. For comparison, similar calculations have been carried out on a model derived from 2 (model 3), where the [CH(3)-S](1)(-) group has been replaced by the neutral [NH(3)](0) group [Neese and Solomon (1998) J. Am. Chem. Soc. 120, 12829-12848]. Both models 2 and 3 contain a formally high-spin Fe(3+) ion (i.e., with empty minority spin orbitals). We found, however, a significant fraction ( approximately 0.6 for 2, approximately 0.8 for 3) of spin (equivalently charge) spread over two occupied (minority spin) orbitals. The quadrupole splitting value for 2 is found to be negative and matches quite well the experimental value. The computed quadrupole tensors are

  12. Modification of polyethylene glycol onto solid lipid nanoparticles encapsulating a novel chemotherapeutic agent (PK-L4 to enhance solubility for injection delivery

    Directory of Open Access Journals (Sweden)

    Fang YP

    2012-09-01

    Full Text Available Yi-Ping Fang,1 Pao-Chu Wu,2 Yaw-Bin Huang,3 Cherng-Chyi Tzeng,4 Yeh-Long Chen,4 Yu-Han Hung,2 Ming-Jun Tsai,5,6 Yi-Hung Tsai31Department of Biotechnology, Yuanpei University, Hsinchu, Taiwan; 2School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan; 3Graduate Institute of Clinical Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan; 4School of Medicinal and Applied Chemistry, College of Life Science, Kaohsiung Medical University, Kaohsiung, Taiwan; 5Department of Neurology, China Medical University Hospital, Taichung, Taiwan; 6School of Medicine, Medical College, China Medical University, Taichung, TaiwanBackground: The synthetic potential chemotherapeutic agent 3-Chloro-4-[(4-methoxyphenylamino]furo[2,3-b]quinoline (PK-L4 is an analog of amsacrine. The half-life of PK-L4 is longer than that of amsacrine; however, PK-L4 is difficult to dissolve in aqueous media, which is problematic for administration by intravenous injection.Aims: To utilize solid lipid nanoparticles (SLNs modified with polyethylene glycol (PEG to improve the delivery of PK-L4 and investigate its biodistribution behavior after intravenous administration.Results: The particle size of the PK-L4-loaded SLNs was 47.3 nm and the size of the PEGylated form was smaller, at 28 nm. The entrapment efficiency (EE% of PK-L4 in SLNs with and without PEG showed a high capacity of approximately 100% encapsulation. Results also showed that the amount of PK-L4 released over a prolonged period from SLNs both with and without PEG was comparable to the non-formulated group, with 16.48% and 30.04%, respectively, of the drug being released, which fit a zero-order equation. The half-maximal inhibitory concentration values of PK-L4-loaded SLNs with and those without PEG were significantly reduced by 45%–64% in the human lung carcinoma cell line (A549, 99% in the human breast adenocarcinoma cell line with estrogen receptor (MCF7, and 95% in

  13. Increased risk of community-acquired pneumonia in COPD patients with comorbid cardiovascular disease

    Directory of Open Access Journals (Sweden)

    Lin SH

    2016-12-01

    Full Text Available Sheng-Hao Lin,1,2 Diahn-Warng Perng,3,4 Ching-Pei Chen,5,6 Woei-Horng Chai,1 Chin-Shui Yeh,1 Chew-Teng Kor,7 Shih-Lung Cheng,8,9 Jeremy JW Chen,2,* Ching-Hsiung Lin1,10,11,* 1Department of Internal Medicine, Division of Chest Medicine, Changhua Christian Hospital, Changhua, 2Institute of Biomedical Sciences, National Chung Hsing University, Taichung, 3Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, 4School of Medicine, National Yang-Ming University, Taipei, 5Department of Internal Medicine, Division of Cardiology, Changhua Christian Hospital, 6Department of Beauty Science and Graduate Institute of Beauty Science Technology, Chien-Kuo Technology University, 7Department of Internal Medicine, Internal Medicine Research Center, Changhua Christian Hospital, Changhua, 8Department of Internal Medicine, Far Eastern Memorial Hospital, Taipei, 9Department of Chemical Engineering and Materials Science, Yuan Ze University, Zhongli City, Taoyuan, 10Department of Respiratory Care, College of Health Sciences, Chang Jung Christian University, Tainan, 11School of Medicine, Chung Shan Medical University, Taichung, Taiwan *These authors contributed equally to this work Background and objective: COPD patients with community-acquired pneumonia (CAP have worse clinical outcomes, as compared to those without COPD. Cardiovascular disease (CVD is a common comorbidity for COPD patients. Whether COPD with comorbid CVD will increase the risk of CAP is not well investigated. The incidence and factors associated with CAP in COPD patients with and without CVD were analyzed. Methods: The medical records of patients with newly diagnosed COPD between 2007 and 2010 were reviewed. The patients’ characteristics, medical history of CVD, occurrence of CAP, and type of medication were recorded. Kaplan–Meier curves were used to assess the differences in cumulative incidence of CAP. Cox’s proportional hazards regression model was used to determine the

  14. The formation of post-spreading volcanic ridges in the South China Sea

    Science.gov (United States)

    Zhao, Minghui; Sibuet, Jean-Claude; He, Enyuan; Tan, Pingchuan; Wang, Jian; Qiu, Xuelin

    2016-04-01

    , 41176053). References Sibuet J.-C., Yeh Y.-C. and Lee C.-S., 2016 revised. Geodynamics of the South China Sea. Tectonophysics. Holbrook, W. S., H. C. Larsen, J. Korenaga, et al., 2001. Mantle thermal structure and active upwelling during continental breakup in the North Atlantic, Earth Planet. Sci. Lett., 190, 251-266. Korenaga, J., P.B.Kelemen, W.S. Holbrook., 2002. Methods for resolving the origin of large igneous provinces from crustal seismology. Journal of Geophysical research: Solid Earth (1978-2012), 107(B9), 2178,doi:10.1029/2001JB001030. Castillo, P. R., Clague, D. A., Davis, A. S., et al., 2010. Petrogenesis of Davidson Seamount lavas and its implications for fossil spreading center and intraplate magmatism in the eastern Pacific. Geochemistry, Geophysics, Geosystems, 11, Q02005, doi:10.1029/2009GC002992.

  15. Urban Vulnerability Assessment to Seismic Hazard through Spatial Multi-Criteria Analysis. Case Study: the Bucharest Municipality/Romania

    Science.gov (United States)

    Armas, Iuliana; Dumitrascu, Silvia; Bostenaru, Maria

    2010-05-01

    conditions). In effect, the example of Bucharest demonstrates how the results shape the ‘vulnerability to seismic hazard profile of the city, based on which decision makers could develop proper mitigation strategies. To sum up, the use of an analytical framework as the standard Spatial Multi-Criteria Analysis (SMCA) - despite all difficulties in creating justifiable weights (Yeh et al., 1999) - results in accurate estimations of the state of the urban system. Although this method was often mistrusted by decision makers (Janssen, 2001), we consider that the results can represent, based on precisely the level of generalization, a decision support framework for policy makers to critically reflect on possible risk mitigation plans. Further study will lead to the improvement of the analysis by integrating a series of daytime and nighttime scenarios and a better definition of the constructed space variables.

  16. Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015; Budapest (Hungary; September 16-20, 2015; Session “Pharmacology”

    Directory of Open Access Journals (Sweden)

    Various Authors

    2015-09-01

    Full Text Available Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015; Budapest (Hungary; September 16-20, 2015ORGANIZING INSTITUTIONSEuropean Society for Neonatology (ESN, European Society for Paediatric Research (ESPR, Union of European Neonatal & Perinatal Societies (UENPS, European Foundation for the Care of Newborn Infants (EFCNI, with the local host of Hungarian Society of Perinatology and Obstetric Anesthesiology, Hungarian Society of Perinatology (MPT, supported by Council of International Neonatal Nurses (COINN, organizing secretariat MCA Scientific EventsPROGRAMME COMMITTEEArtúr Beke (Hungarian Society, Morten Breindahl (ESN, Giuseppe Buonocore (UENPS, Pierre Gressens (ESPR, Silke Mader (EFCNI, Manuel Sánchez Luna (UENPS, Miklós Szabó (Hungarian Society of Perinatology, Luc Zimmermann (ESPR Session “Pharmacology”ABS 1. BABY SKIN CARE PRODUCTS • P. Doro, R. Abraham, D. Agoston, J. Balog, R.Z. CsomaABS 2. MATHEMATICAL MODELING TO PREDICT IN-HOSPITAL NATURAL WEIGHT CHANGES IN TERM NEONATES • S. Kasser, M. Wilbaux, C. De Angelis, H. Rickenbacher, N. Klarer, J.N. Van Den Anker, M. Pfister, S. WellmannABS 3. IMPROVING PARENTERAL NUTRITION IN THE NEONATE – A PRACTICAL GUIDELINE • H. Reigstad, D. Moster, I. Grønlie, A. BlystadABS 4. INVOLUTION OF RETINOPATHY OF PREMATURITY AND NEURODEVELOPMENTAL OUTCOME AFTER BEVACIZUMAB TREATMENT • Y.-S. Chang, P.-N. Tsao, C.-Y. Chen, H.-C. Chou, W.-S. Hsieh, P.-T. YehABS 5. RELATIONSHIP BETWEEN ADVERSE DRUG REACTIONS AND OFF-LABEL/UNLICENSED DRUG USE IN HOSPITALISED CHILDREN. EREMI STUDY • K.A. Nguyen, Y. Mimouni, A. Lajoinie, N. Paret, S. Malik, L. El-Amrani, L. Milliat-Guittard, C. Carcel, A. Portefaix, A.M. Schott, T. Vial, B. KassaiABS 6. A SYSTEMATIC REVIEW OF OFF-LABEL AND UNLICENSED DRUGS USE AND ADVERSE DRUG REACTIONS IN HOSPITALIZED CHILDREN • N. David, K.A. Nguyen, Y. Mimouni, A. Lajoinie, S. Malik, B. KassaiABS 7. EFFICACY AND SAFETY OF PROPOFOL SEDATION

  17. Closure of Tethys and early stages of Himalayan evolution: constraints from the detrital record, Ladakh, India

    Science.gov (United States)

    Jenks, D.; Najman, Y.; Godin, L.; Parrish, R.; Horstwood, M.; Green, O.; Bown, P.; Garzanti, E.; Willems, H.

    2009-04-01

    , R. I., Stephenson, B., and McCarron, J., 1997, Geological Magazine, 134 (3), 297-316. [6]Rowley, D.B., 1998. Journal of Geology 106, 229-235. [7] Hodges, K. V., 2000, Geological Society of America Bulletin, 112, (3), 324-350. [8] Garzanti, E., Baud, A., and Mascle, G., 1987, Geodinamica Acta, 1, (4-5), 297-312. [9] Nicora, A., Garzanti, E., Fois, E., 1987, Riv. It. Peleont. Strat., 92, 439-496. [10] Fuchs, G., Willems, H., 1990, Jahrbuche Geologische Bundenstalt, 133, 259-273. [11] Critelli, S., and Garzanti, E., 1994, Sedimentary Geology, 89, (3-4), 265-284. [12] Zhu, B., Kidd, W. S. F., Rowley, D., Currie, B., and Shafique, N., 2005, Journal of Geology, 113, 265-285. [13] Najman, Y., unpublished data. [14] Wen, D.-R., Liu, D., Chung, S-L., Chu, M-F., Ji, J., Zhang, Q., Song, B., Lee, T-Y., Yeh, M-W. and Lo, C-H., 2008, Chemical Geology, 252, 191-201.

  18. Fluid-rock interaction: A reactive transport approach

    Energy Technology Data Exchange (ETDEWEB)

    Steefel, C.; Maher, K.

    2009-04-01

    irreversible. Helgeson's pioneering approach was given a more formal kinetic basis (including the introduction of real time rather than reaction progress as the independent variable) in subsequent studies (Lasaga 1981; Aagaard and Helgeson 1982; Lasaga 1984). The reaction path approach can be used to describe chemical processes in a batch or closed system (e.g., a laboratory beaker), but such systems are of limited interest in the Earth sciences where the driving force for most reactions is transport. Lichtner (1988) clarified the application of the reaction path models to water-rock interaction involving transport by demonstrating that they could be used to describe pure advective transport through porous media. By adopting a reference frame which followed the fluid packet as it moved through the medium, the reaction progress variable could be thought of as travel time instead. Multi-component reactive transport models that could treat any combination of transport and biogeochemical processes date back to the early 1980s. Berner and his students applied continuum reactive transport models to describe processes taking place during the early diagenesis of marine sediments (Berner 1980). Lichtner (1985) outlined much of the basic theory for a continuum model for multicomponent reactive transport. Yeh and Tripathi (1989) also presented the theoretical and numerical basis for the treatment of reactive contaminant transport. Steefel and Lasaga (1994) presented a reactive flow and transport model for nonisothermal, kinetically-controlled water-rock interaction and fracture sealing in hydrothermal systems based on simultaneous numerical solution of both reaction and transport This chapter begins with a review of the important transport processes that affect or even control fluid-rock interaction. This is followed by a general introduction to the governing equations for reactive transport, which are broadly applicable to both qualitative and quantitative interpretations of fluid

  19. 青少年疏离感与病理性互联网使用的关系:家庭功能和同伴接纳的调节效应检验%Relationship between Adolescents' Alienation and Pathological Internet Use:Testing the Moderating Effect of Family Functioning and Peer Acceptance

    Institute of Scientific and Technical Information of China (English)

    徐夫真; 张文新

    2011-01-01

    通过对549名初一至高二年级城市青少年的问卷调查,考察了青少年病理性互联网使用的特点及其与疏离感之间的关系,并对家庭功能和同伴接纳是否可以调节疏离感与病理性互联网使用之间的关系进行了检验.结果发现:(1)在所有使用互联网的青少年被试中,网络成瘾群体的检出率为8.93%;(2)女青少年病理性互联网使用的突显性水平高于男青少年.在病理性互联网使用的消极后果上,初一青少年高于高一、初三和高二青少年.但青少年病理性互联网使用总体上不存在显著的性别和年级差异;(3)疏离感较高的青少年病理性互联网使用的水平也较高,健康的家庭功能可以保护疏离感高的青少年减少病理性互联网使用,但同伴接纳对高疏离感青少年减少病理性互联网使用不具有保护性作用.%Internet as an important media has become an inevitable part of adolescents' lives. Although Internet meet various needs of adolescents, such as expressing emotions and seeking sense of belonging, misuse of Internet could result in psychological, social and academic problems during adolescence (Young & Rodgers, 1998; Davis,2001; Lei & Yang, 2007). In this study, we use the term of pathological Internet use (PIU) to refer to the degree of adolescents' misuse of Internet and its negative outcomes.Alienation is a negative emotional state, reflecting individual incompetence in dealing with others and establishing an effective bond with social groups. Existing researches demonstrated that adolescents with high alienation were inclined to use Internet excessively. Researches on the relationship between pathological Internet use and adolescents' negative emotions reveal that positive factors of family and peer groups may be of important buffering effects (Thomas & Schare, 2000; Slater, 2003; Gross, 2004; Gao & Chen, 2006; Yeh et al.,2008). Thus it is reasonable to assume that family functioning and

  20. Contributions of GRACE to Climate Monitoring

    Science.gov (United States)

    Rodell, Matthew; Famiglietti, James; Chambers, Don P.; Wahr, John

    2011-01-01

    western Antarctica. For 2002 to present, the rate of ice mass loss has been 200 to 300 GT/yr in Greenland and 70 to 210 GT/yr in Antarctica, and some scientists are suggesting that the rates are accelerating. Similarly, GRACE has been used to monitor mass changes in alpine glaciers. Tamisiea et al. first characterized glacier melt along the southern coast of Alaska, more recently estimated to be occurring at a rate of 84 GT/yr. Chen et al. estimated that Patagonian glaciers are melting at a rate of 28 GT/yr, and estimated that the high mountains of central Asia lose ice at a rate of 47 GT/yr. Tapley et al. and Wahr et al. presented the first GRACE based estimates of changes in column-integrated terrestrial water storage (TWS; the sum of ground-water, soil moisture, surface waters, snow, ice, and water stored in vegetation) at continental scales. Since then, dozens of studies have shown that GRACE based estimates of regional to continental scale TWS variations agree with independent information, and some innovative uses of GRACE data have been developed. Rodell et al. (2004) and Swenson and Wahr (2006) demonstrated that by combining GRACE derived terrestrial water storage changes with observations of precipitation and runoff in a river basin scale water budget, it was possible to produce new estimates of evapotranspiration and atmospheric moisture convergence, essential climate variables that are difficult to estimate accurately. Similarly, GRACE has been used to constrain estimates of global river discharge and the contribution of changes in TWS to sea level rise. Crowley et al. observed a negative correlation between interannual TWS anomalies in the Amazon and the Congo River basin. Yeh et al. and Rodell et al. estimated regionally averaged groundwater storage variations based on GRACE and auxiliary observations. Rodell et al. and Tiwari et al. applied that method to quantify massive groundwater depletion in northern India caused by over reliance on aquifers for irration

  1. Direct CP violation in hadronic B decays

    Institute of Scientific and Technical Information of China (English)

    HONG; Bihai

    2006-01-01

    .Extraction of Vub from decay B0 → K+π-lepton neutrino.Phys Rev Lett,1995,74:4388-4391[18]Li H N,Yu H L.PQCD analysis of exclusive charmless B meson decay spectra.Phys Lett B,1995,353:301-305[19]Li H N,Yu H L.Perturbative QCD analysis of B meson decays.Phys Rev D,1996,53:2480-2490[20]Chang C H,Li H N.Three-scale factorization theorem and effective field theory.Phys Rev D,1997,55:5577-5580[21]Yeh T W,Li H N.Factorization theorems,effective field theory and nonleptonic heavy meson decays.Phys Rev D,1997,56:1615-1631[22]Cheng H Y,Li H N,Yang K C.Gauge invariant and infrared finite theory of nonleptonic heavy meson decays.Phys Rev D,1999,60:094005[23]Buchalla G,Buras A J,Lautenbacher M E.Weak decays beyond leading logarithms.Rev Mod Phys,1996,68:1125-1144[24]Neubert M,Rieckert V,Stech B,et al.Exclusive Weak Decays of B Mesons,Heavy Flavors.Singapore:World Scientific Publishing Co.,1998.294-344[25]Neubert M,Stech B.Nonleptonic weak decays of B mesons.High Energy Phys,1998,15:294-344[26]Ali A,Kramer G,Lu C D.CP-violating asymmetries for charmless non-leptonic decays B0 → PP,PV,VV in the factorization approach.Phys Rev D,1999,59:014005[27]Lu C D.Calculation of direct CP violation in B decays.In:Chen H Y,Hou W S,eds.Proceedings of 3rd International Conference on B Physics and CP Violation.Singapore:World Scientific Publishing Co.,1999,245-251[28]Bander M,Silverman D,Soni A.CP noninvariance in the decays of heavy charged quark systems.Phys Rev Lett,1979,43:242-245[29]Gerard J M,Hou W S.CP violation in inclusive and exclusive charmless B decays.Phys Rev D,1991,43:2909-2930[30]Simma H,Eilam G,Wyler D.On the rate asymmetries in charged B decays.Nucl Phys B,1991,352:367-384[31]Du D S,Huang C S,Wei Z T,et al.Sudakov effects in BBNS approach.Phys Lett B,2001,520:50-58[32]Lu C D,Ukai K,Yang M Z.Branching ratio and CP violation of B →ππ decays in perturbative QCD approach.Phys Rev D,2001,63:074009[33]Lu C D,Yang M Z.B →πρ,πω decays in perturbative QCD approach.Eur Phys J C,2002