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Sample records for kamland assuming cpt

  1. Kamland Results

    CERN Document Server

    Inoue, K

    2003-01-01

    The LMA solution of the solar neutrino problem has been explored with the 1,000 ton liquid scinatillator detector, KamLAND. It utilizes nuclear power reactors distributing effectively 180km from the experimental site. Comparing observed neutrino rate with the calculation of reactor operation histories, an evidence for reactor neutrino disapearance has been obtained from 162 ton-year exposure data. This deficit is only compatible with the LMA solution and the other solutions in the two neutrino oscillation hypotheisis are excluded at 99.95% confidence level.

  2. KamLAND's precision neutrino oscillation measurements

    Science.gov (United States)

    Decowski, M. P.

    2016-07-01

    The KamLAND experiment started operation in the Spring of 2002 and is operational to this day. The experiment observes signals from electron antineutrinos from distant nuclear reactors. The program, spanning more than a decade, allowed the determination of LMA-MSW as the solution to the solar neutrino transformation results (under the assumption of CPT invariance) and the measurement of various neutrino oscillation parameters. In particular, the solar mass-splitting Δ m212 was determined to high precision. Besides the study of neutrino oscillation, KamLAND started the investigation of geologically produced antineutrinos (geo-ν‾e). The collaboration also reported on a variety of other topics related to particle and astroparticle physics.

  3. Limits on CPT violation from solar neutrinos

    CERN Document Server

    Diaz, Jorge S

    2016-01-01

    Violations of CPT invariance can induce neutrino-to-antineutrino transitions. We study this effect for solar neutrinos and use the upper bound on the solar neutrino-to-antineutrino transition probability from the KamLAND experiment to constrain CPT-symmetry-violating coefficients of the general Standard-Model Extension. The long propagation distance from the Sun to the Earth allows us to improve existing limits by factors ranging from about a thousand to $10^{11}$.

  4. Precision Measurement of Neutrino Oscillation Parameters with KamLAND

    Energy Technology Data Exchange (ETDEWEB)

    O' Donnell, Thomas [Univ. of California, Berkeley, CA (United States)

    2011-12-01

    This dissertation describes a measurement of the neutrino oscillation parameters m2 21, θ12 and constraints on θ13 based on a study of reactor antineutrinos at a baseline of ~ 180 km with the KamLAND detector. The data presented here was collected between April 2002 and November 2009, and amounts to a total exposure of 2.64 ± 0.07 × 1032 proton-years. For this exposure we expect 2140 ± 74(syst) antineutrino candidates from reactors, assuming standard model neutrino behavior, and 350±88(syst) candidates from background. The number observed is 1614. The ratio of background-subtracted candidates observed to expected is (NObs - NBkg)/ (NExp) = 0.59 ± 0.02(stat) ± 0.045(syst) which confirms reactor neutrino disappearance at greater than 5σ significance. Interpreting this deficit as being due to neutrino oscillation, the best-fit oscillation parameters from a three-flavor analysis are m2 21= 7.60+0.20 -0.19×10-5eV2, θ12 = 32.5 ± 2.9 degrees and sin2 θ13 = 0.025+0.035 -0.035, the 95% confidence-level upper limit on sin2 θ13 is sin2 θ13 < 0.083. Assuming CPT invariance, a combined analysis of KamLAND and solar neutrino data yields best-fit values: m2 21 = 7.60+0.20 -0.20 × 10-5eV2, θ12 = 33.5+1.0 -1.1 degrees, and sin2 θ13 = 0.013 ± 0.028 or sin2 θ13 < 0.06 at the 95% confidence level.

  5. 7Be Solar Neutrino Measurement with KamLAND

    CERN Document Server

    Gando, A; Hanakago, H; Ikeda, H; Inoue, K; Ishidoshiro, K; Ishikawa, H; Kishimoto, Y; Koga, M; Matsuda, R; Matsuda, S; Mitsui, T; Motoki, D; Nakajima, K; Nakamura, K; Obata, A; Oki, A; Oki, Y; Otani, M; Shimizu, I; Shirai, J; Suzuki, A; Tamae, K; Ueshima, K; Watanabe, H; Xu, B D; Yamada, S; Yamauchi, Y; Yoshida, H; Kozlov, A; Takemoto, Y; Yoshida, S; Grant, C; Keefer, G; McKee, D W; Piepke, A; Banks, T I; Bloxham, T; Freedman, S J; Fujikawa, B K; Han, K; Hsu, L; Ichimura, K; Murayama, H; O'Donnell, T; Steiner, H M; Winslow, L A; Dwyer, D; Mauger, C; McKeown, R D; Zhang, C; Berger, B E; Lane, C E; Maricic, J; Miletic, T; Learned, J G; Sakai, M; Horton-Smith, G A; Tang, A; Downum, K E; Tolich, K; Efremenko, Y; Kamyshkov, Y; Perevozchikov, O; Karwowski, H J; Markoff, D M; Tornow, W; Detwiler, J A; Enomoto, S; Heeger, K; Decowski, M P

    2014-01-01

    We report a measurement of the neutrino-electron elastic scattering rate of 862 keV 7Be solar neutrinos based on a 165.4 kton-day exposure of KamLAND. The observed rate is 582 +/- 90 (kton-day)^-1, which corresponds to a 862 keV 7Be solar neutrino flux of (3.26 +/- 0.50) x 10^9 cm^-2s^-1, assuming a pure electron flavor flux. Comparing this flux with the standard solar model prediction and further assuming three flavor mixing, a nu_e survival probability of 0.66 +/- 0.14 is determined from the KamLAND data. Utilizing a global three flavor oscillation analysis, we obtain a total 7Be solar neutrino flux of (5.82 +/- 0.98) x 10^9 cm^-2s^-1, which is consistent with the standard solar model predictions.

  6. 7Be solar neutrino measurement with KamLAND

    NARCIS (Netherlands)

    Gando, A.; et al., [Unknown; Decowski, M.P.

    2015-01-01

    We report a measurement of the neutrino-electron elastic scattering rate of 862 keV Be7 solar neutrinos based on a 165.4 kt d exposure of KamLAND. The observed rate is 582±94(kt d)−1, which corresponds to an 862-keV Be7 solar neutrino flux of (3.26±0.52)×109cm−2s−1, assuming a pure electron-flavor f

  7. Low Background Phase of KamLAND

    Science.gov (United States)

    Keefer, Gregory

    2008-04-01

    The KamLAND collaboration operates a 1 kton liquid scintillation detector in the Kamioka mine in Japan. KamLAND's main scientific results are the precision measurement of the solar δm^2 utilizing reactor anti-neutrinos and first evidence for the observation of geologically produced anti-neutrinos. The KamLAND collaboration has been working toward upgrading the detector for a low background phase. During the spring of 2007, we performed the first phase of purification by circulating 1.3 ktons of KamLAND liquid scintillator through a newly developed distillation and purging system. The ultimate goal of purification is to allow for a direct measurement of the 862 keV, ^7Be neutrinos originating from the Sun. A description of the purification process, liquid scintillator quality control measures, and detector monitoring will be presented. The achieved background reduction after this first phase of purification and planned future work on KamLAND will be discussed.

  8. Tests of CPT with CPLEAR

    CERN Document Server

    Mikuz, M

    2000-01-01

    Measurements of K/sup 0//K/sup 0/ time dependent asymmetries in pionic and semileptonic decays with the CPLEAR detector enabled a complete determination of CPT violation parameters in the neutral kaon system. A global fit using the Bell-Steinberger relation yielded values for the CPT violation parameter in K/sup 0/ mixing Im( delta ) =(2.4+or-5.0)*10/sup -5/ and Re( delta )=(2.4+or-2.8)*10/sup -4/, the determination of the latter relying essentially on CPLEAR measurements. In addition, CPT violation parameters in semileptonic decays Re(y) and Re(x/sub -/) could be measured for the first time. From these results, the equality of K/sup 0/ and K/sup 0/ masses and lifetimes is tested at the 10/sup -18/ GeV level. Assuming CPT conservation in decays, the 90% C.L. limit on m(K/sup 0/)-m(K/sup 0 /) can be pushed down to 5*10/sup -19/ GeV. CPT violation amplitudes in I=0 and I=2 decays into two pions were excluded at the level of 10 /sup -4/ of the corresponding CPT conserving decay amplitudes. (8 refs).

  9. Reactor On-Off Antineutrino Measurement with KamLAND

    CERN Document Server

    ,

    2013-01-01

    The recent long-term shutdown of Japanese nuclear reactors has resulted in a significantly reduced reactor $\\bar{nu}_{e}$ flux at KamLAND. This running condition provides a unique opportunity to confirm and constrain backgrounds for the reactor $\\bar{nu}_{e}$ oscillation analysis. The data set also has improved sensitivity for other $\\bar{nu}_{e}$ signals, in particular $\\bar{nu}_{e}$'s produced in $\\beta$-decays from $^{238}$U and $^{232}$Th within the Earth's interior, whose energy spectrum overlaps with that of reactor $\\bar{nu}_{e}$'s. Including constraints on $\\theta_{13}$ from accelerator and short-baseline reactor neutrino experiments, a combined three-flavor analysis of solar and KamLAND data gives fit values for the oscillation parameters of $tan^{2} \\theta_{12} = 0.436^{+0.029}_{-0.025}$, $\\Delta m^{2}_{21} = 7.53^{+0.18}_{-0.18} \\times 10^{-5} {eV}^{2}$, and $sin^{2} \\theta_{13} = 0.023^{+0.002}_{-0.002}$. Assuming a chondritic Th/U mass ratio, we obtain $116^{+28}_{-27}$ $\\bar{nu}_{e}$ events from...

  10. KamLAND Results and Future

    Science.gov (United States)

    Mitsui, Tadao; KamLAND Collaboration

    2011-12-01

    KamLAND results, current status, and near-future plans are reviewed. For reactor and geoneutrino physics, reduction of the systematic uncertainties is underway, while taking subsequent data. For the detection of 7Be solar neutrinos, purification of the scintillator by distillation will start soon.

  11. Parameter Limits for Neutrino Oscillation with Decoherence in KamLAND

    CERN Document Server

    Gomes, G Balieiro; de Holanda, P C; Oliveira, R L N

    2016-01-01

    In the framework of quantum open systems we analyze data from KamLAND by using a model that considers neutrino oscillation in a three-family approximation with the inclusion of the decoherence effect. Using a $\\chi^2$ test we find new limits for the decoherence parameter which we call $\\gamma$, considering the most recent data by KamLAND. Assuming an energy dependence of the type $ \\gamma = \\gamma_0 \\left( E/E_0 \\right) ^n$, in 95 \\% C.L. the limits found are $3.7 \\times 10^{-27} GeV$ for $ n=-1$, $6.8 \\times 10^{-22} GeV$ for $ n=0$, and $1.5 \\times 10^{-16} GeV$ for $ n=1 $ on the energy dependence.

  12. Solar Neutrino Oscillation Parameters after KamLAND

    CERN Document Server

    Goswami, S; Choubey, S; Goswami, Srubabati; Bandyopadhyay, Abhijit; Choubey, Sandhya

    2003-01-01

    We explore the impact of the data from the KamLAND experiment in constraining neutrino mass and mixing angles involved in solar neutrino oscillations. In particular we discuss the precision with which we can determine the the mass squared difference $\\Delta m^2_{solar}$ and the mixing angle $\\theta_{solar}$ from combined solar and KamLAND data. We show that the precision with which $\\Delta m^_{solar}$ can be determined improves drastically with the KamLAND data but the sensitivity of KamLAND to the mixing angle is not as good. We study the effect of enhanced statistics in KamLAND as well as reduced systematics in improving the precision. We also show the effect of the SNO salt data in improving the precision. Finally we discuss how a dedicated reactor experiment with a baseline of 70 km can improve the $\\theta_{solar}$ sensitivity by a large amount.

  13. Combined analysis of KamLAND and Borexino neutrino signals from Th and U decays in the Earth's interior

    CERN Document Server

    Fogli, G L; Palazzo, A; Rotunno, A M

    2010-01-01

    The KamLAND and Borexino experiments have detected electron antineutrinos produced in the decay chains of natural thorium and uranium (Th and U geoneutrinos). We analyze the energy spectra of current geoneutrino data in combination with solar and long-baseline reactor neutrino data, with marginalized three-neutrino oscillation parameters. We consider the case with unconstrained Th and U event rates in KamLAND and Borexino, as well as cases with fewer degrees of freedom, as obtained by successively assuming for both experiments a common Th/U ratio, a common scaling of Th+U event rates, and a chondritic Th/U value. In combination, KamLAND and Borexino can reject the null hypothesis (no geoneutrino signal) at 5 sigma. Interesting bounds or indications emerge on the Th+U geoneutrino rates and on the Th/U ratio, in broad agreement with typical Earth model expectations. Conversely, the results disfavor the hypothesis of a georeactor in the Earth's core, if its power exceeds a few TW. The interplay of KamLAND and Bo...

  14. CPT Symmetry Without Hermiticity

    CERN Document Server

    Mannheim, Philip D

    2016-01-01

    In the literature the $CPT$ theorem has only been established for Hamiltonians that are Hermitian. Here we extend the $CPT$ theorem to quantum field theories with non-Hermitian Hamiltonians. Our derivation is a quite minimal one as it requires only the time independent evolution of scalar products and invariance under complex Lorentz transformations. The first of these requirements does not force the Hamiltonian to be Hermitian. Rather, it forces its eigenvalues to either be real or to appear in complex conjugate pairs, forces the eigenvectors of such conjugate pairs to be conjugates of each other, and forces the Hamiltonian to admit of an antilinear symmetry. The latter requirement then forces this antilinear symmetry to be $CPT$, with Hermiticity of a Hamiltonian thus only being a sufficient condition for $CPT$ symmetry and not a necessary one. $CPT$ symmetry thus has primacy over Hermiticity, and it rather than Hermiticity should be taken as a guiding principle for constructing quantum theories. With confo...

  15. Extrinsic and intrinsic CPT asymmetries in neutrino oscillations

    Directory of Open Access Journals (Sweden)

    Tommy Ohlsson

    2015-04-01

    Full Text Available We reconsider the extrinsic and possible intrinsic CPT violation in neutrino oscillations, and point out an identity, i.e., AαβCP=AβαCPT+AαβT, among the CP, T, and CPT asymmetries in oscillations. For three-flavor oscillations in matter of constant density, the extrinsic CPT asymmetries AeeCPT, AeμCPT, AμeCPT, and AμμCPT caused by Earth matter effects have been calculated in the plane of different neutrino energies and baseline lengths. It is found that two analytical conditions can be implemented to describe the main structure of the contours of vanishing extrinsic CPT asymmetries. Finally, without assuming intrinsic CPT symmetry in the neutrino sector, we investigate the possibility to constrain the difference of the neutrino CP-violating phase δ and the antineutrino one δ¯ using a low-energy neutrino factory and the super-beam experiment ESSνSB. We find that |δ−δ¯|≲0.35π in the former case and |δ−δ¯|≲0.7π in the latter case can be achieved at the 3σ confidence level if δ=δ¯=π/2 is assumed.

  16. KamLAND results and the radiogenic terrestrial heat

    CERN Document Server

    Fiorentini, G; Mantovani, F; Ricci, B; Fiorentini, Gianni; Lissia, Marcello; Mantovani, Fabio; Ricci, Barbara

    2005-01-01

    We find that recent results from the KamLAND collaboration on geologically produced antineutrinos, N(U+Th) = 28+16-15 events, correspond to a radiogenic heat production from Uranium and Thorium decay chains H(U+Th) = 38+35-33 TW. The 99% confidence limit on the geo-neutrino signal translates into the upper bound H(U+Th) < 162 TW, which is much weaker than that claimed by KamLAND, H(U+Th) < 60 TW, based on a too narrow class of geological models. We also performed an analysis of KamLAND data including recent high precision measurements of the C13(\\alpha,n)O16 cross section. The result, N(U+Th) = 31+14-13, corroborates the evidence (approx 2.5\\sigma) for geo-neutrinos in KamLAND data.

  17. Neutrino Oscillation Parameters After High Statistics KamLAND Results

    CERN Document Server

    Bandyopadhyay, Abhijit; Goswami, Srubabati; Petcov, S T; Roy, D P

    2008-01-01

    We do a re-analysis to asses the impact of the results of the Borexino experiment and the recent 2.8 KTy KamLAND data on the solar neutrino oscillation parameters. The current Borexino results are found to have no impact on the allowed solar neutrino parameter space. The new KamLAND data causes a significant reduction of the allowed range of $\\Delta m^2_{21}$, determining it with an unprecedented precision of 8.3% at 3$\\sigma$. The precision of $\\Delta m^2_{21}$ is controlled practically by the KamLAND data alone. Inclusion of new KamLAND results also improves the upper bound on $\\sin^2\\theta_{12}$, but the precision of this parameter continues to be controlled by the solar data. The third mixing angle is constrained to be $\\sin^2\\theta_{13} < 0.063$ at $3\\sigma$ from a combined fit to the solar, KamLAND, atmospheric and CHOOZ results. We also address the issue of how much further reduction of allowed range of $\\Delta m^2_{21}$ and $\\sin^2\\theta_{12}$ is possible with increased statistics from KamLAND. We ...

  18. CPT 2004 BRISBANE

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Dear Colleagues, On behalf of the National Organizing Committee I am delighted to invite you to CPT2004 which will be hosted by the Australian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) and the Division of Clinical Pharmacology of IUPHAR. The South East Asian Western Pacific regional grouping of pharmacologists will be extensively involved. Major areas to be covered in an exciting scientific program will include drug discovery and development, the latest advances in therapeutic areas, clinical toxicology, pharmacogenomics, political and social pharmacology, education, quality use of medicines, pharmacoepidemiology and pharmacoeconomics. We will provide an outstanding social program and give your accompanying persons a personal welcome and sense of involvement. The 18th World Congress of the Intemational Society for Heart Research (ISHR) will be held at the same venue in Brisbane directly following CPT2004, and the programs will be coordinated to facilitate attendance at both meetings. Come to CPT2004 in Australia and enjoy our unique environment, and attractions that are as varied as skiing in August, Ulum (Ayers Rock) and the Great Barrier Reef. For any further enquiries, please contact: CPT2004 Secretariat, GPO Box 2609 Sydney NSW 2001 Australia Tel: +61-2-9241 1478 Fax: + 61-2-9521 3552 E-mail: reply@icmsaust. com. auIntemet: www. cpt @ icmsaust. com. au

  19. Enhanced Constraints on theta13 from A Three-Flavor Oscillation Analysis of Reactor Antineutrinos at KamLAND

    Energy Technology Data Exchange (ETDEWEB)

    The KamLAND Collaboration; Gando, A.; Gando, Y.; Ichimura, K.; Ikeda, H.; Inoue, K.; Kibe, Y.; Kishimoto, Y.; Koga, M.; Minekawa, Y.; Mitsui, T.; Morikawa, T.; Nagai, N.; Nakajima, K.; Nakamura, K.; Narita, K.; Shimizu, I.; Shimizu, Y.; Shirai, J.; Suekane, F.; Suzuki, A.; Takahashi, H.; Takahashi, N.; Takemoto, Y.; Tamae, K.; Watanabe, H.; Xu, B. D.; Yabumoto, H.; Yoshida, H.; Yoshida, S.; Enomoto, S.; Kozlov, A.; Murayama, H.; Grant, C.; Keefer, G.; Piepke, A.; Banks, T. I.; Bloxham, T.; Detwiler, J. A.; Freedman, S. J.; Fujikawa, B. K.; Han, K.; Kadel, R.; O' Donnell, T.; Steiner, H. M.; Dwyer, D. A.; McKeown, R. D.; Zhang, C.; Berger, B. E.; Lane, C. E.; Maricic, J.; Miletic, T.; Batygov, M.; Learned, J. G.; Matsuno, S.; Sakai, M.; Horton-Smith, G. A.; Downum, K. E.; Gratta, G.; Efremenko, Y.; Perevozchikov, O.; Karwowski, H. J.; Markoff, D. M.; Tornow, W.; Heeger, K. M.; Decowski, M. P.

    2010-09-24

    We present new constraints on the neutrino oscillation parameters {Delta}m{sub 21}{sup 2}, {theta}{sub 12}, and {theta}{sub 13} from a three-flavor analysis of solar and KamLAND data. The KamLAND data set includes data acquired following a radiopurity upgrade and amounts to a total exposure of 3.49 x 10{sup 32} target-proton-year. Under the assumption of CPT invariance, a two-flavor analysis ({theta}{sub 13} = 0) of the KamLAND and solar data yields the best-fit values tan{sup 2} {theta}{sub 12} = 0.444{sub -0.030}{sup +0.036} and {Delta}m{sub 21}{sup 2} = 7.50{sub -0.20}{sup +0.19} x 10{sup -5} eV{sup 2}; a three-flavor analysis with {theta}{sub 13} as a free parameter yields the best-fit values tan{sup 2} {theta}{sub 12} = 0.452{sub -0.033}{sup +0.035}, {Delta}m{sub 21}{sup 2} = 7.50{sub -0.20}{sup +0.19} x 10{sup -5}eV{sup 2}, and sin{sup 2} {theta}{sub 13} = 0.020{sub -0.016}{sup +0.016}. This {theta}{sub 13} interval is consistent with other recent work combining the CHOOZ, atmospheric and long-baseline accelerator experiments. We also present a new global {theta}{sub 13} analysis, incorporating the CHOOZ, atmospheric and accelerator data, which indicates sin{sup 2} {theta}{sub 13} = 0.017{sub -0.009}{sup +0.010}, a nonzero value at the 93% C.L. This finding will be further tested by upcoming accelerator and reactor experiments.

  20. Finsler metrics and CPT

    CERN Document Server

    Sarkar, Sarben

    2010-01-01

    The role of Finsler-like metrics in situations where Lorentz symmetry breaking and also CPT violation are discussed. Various physical instances of such metrics both in quantum gravity and analogue systems are discussed. Both differences and similarities between the cases will be emphasised. In particular the medium of D-particles that arise in string theory will be examined. In this case the breaking of Lorentz invariance, at the level of quantum fluctuations, together with concomitant CPT in certain situations will be analysed. In particular it will be shown correlations for neutral meson pairs will be modified and a new contribution to baryogenesis will appear.

  1. The Solar Neutrino Problem after the first results from Kamland

    CERN Document Server

    Bandyopadhyay, A; Gandhi, R; Goswami, S; Roy, D P; Bandyopadhyay, Abhijit; Choubey, Sandhya; Gandhi, Raj; Goswami, Srubabati

    2003-01-01

    The first results from the KamLAND experiment have provided confirmational evidence for the Large Mixing Angle (LMA) MSW solution to the solar neutrino problem. We do a global analysis of solar and the recently announced KamLAND data (both rate and spectrum) and investigate its effect on the allowed region in the $\\Delta m^2-\\tan^2\\theta$ plane. The best-fit from a combined analysis which uses the KamLAND rate plus global solar data comes at $\\Delta m^2 = 6.06 \\times 10^{-5}$ eV $^2$ and $\\tan^2\\theta=0.42$, very close to the global solar best-fit, leaving a large allowed region within the global solar LMA contour. The inclusion of the KamLAND spectral data in the global fit gives a best-fit $\\Delta m^2 = 7.15 \\times 10^{-5}$ eV $^2$ and $\\tan^2\\theta=0.42$ and constrains the allowed areas within LMA, leaving essentially two allowed zones. Maximal mixing though allowed by the KamLAND data alone is disfavored by the global solar data and remains disallowed at about $3\\sigma$. The LOW solution is now ruled out ...

  2. CPT Results from Ktev

    Science.gov (United States)

    Nguyen, Hogan

    2002-02-01

    We present several preliminary measurements from KTeVREFID="9789812778123_0014FN001"> of the fundamental neutral K parameters, and their implications for CPT violation. A new limit is given on the sidereal time dependence of φ+-. The results are based on data collected in 1996-97.

  3. KamLAND, solar antineutrinos and the solar magnetic field

    CERN Document Server

    Chauhan, B C; Torrente-Lujan, E; Chauhan, Bhag C.; Pulido, Joao

    2003-01-01

    In this work the possibility of detecting solar electron antineutrinos produced by a solar core magnetic field from the KamLAND recent observations is investigated. We find a scaling of the antineutrino probability with respect to the magnetic field profile in the sense that the same probability function can be reproduced by any profile with a suitable peak field value. In this way the solar electron antineutrino spectrum can be unambiguosly predicted. We use this scaling and the negative results indicated by the KamLAND experiment to obtain upper bounds on the solar electron antineutrino flux. We get $\\phi_{\\bar\

  4. Reactor on-off antineutrino measurement with KamLAND

    NARCIS (Netherlands)

    Gando, A.; Gando, Y.; Hanakago, H.; Ikeda, H.; Inoue, K.; Ishidoshiro, K.; Ishikawa, H.; Koga, M.; Matsuda, R.; Matsuda, S.; Mitsui, T.; Motoki, D.; Nakamura, K.; Obata, A.; Oki, A.; Oki, Y.; Otani, M.; Shimizu, I.; Shirai, J.; Suzuki, A.; Takemoto, Y.; Tamae, K.; Ueshima, K.; Watanabe, A.; Xu, B.D.; Yamada, S.; Yamauchi, Y.; Yoshida, H.; Kozlov, A.; Yoshida, S.; Piepke, A.; Banks, T.I.; Fujikawa, B.K.; Han, K.; O'Donnell, T.; Berger, B.E.; Learned, J.G.; Matsuno, S.; Sakai, M.; Efremenko, Y.; Karwowski, H.J.; Markoff, D.M.; Tornow, W.; Detwiler, J.A.; Enomoto, S.; Decowski, M.P.

    2013-01-01

    The recent long-term shutdown of Japanese nuclear reactors has resulted in a significantly reduced reactor ν¯e flux at KamLAND. This running condition provides a unique opportunity to confirm and constrain backgrounds for the reactor ν¯e oscillation analysis. The data set also has improved sensitivi

  5. Analysis of Future KamLAND and Gadolinium Doped SK

    Energy Technology Data Exchange (ETDEWEB)

    Choubey, Sandhya [INFN and SISSA, Trieste (Italy)

    2005-12-15

    We probe in detail the precision expected in the measurement of {delta}m{sub 21}{sup 2} and sin{sup 2}{theta}{sub 12} in the SNO, KamLAND, the proposed SK-Gd and a reactor experiment tuned to the SPMIN.

  6. Neutrino geophysics with KamLAND and future prospects

    CERN Document Server

    Enomoto, S; Inoue, K; Suzuki, A

    2005-01-01

    The Kamioka liquid scintillator anti-neutrino detector (KamLAND) is a low-energy and low-background neutrino detector which could be a useful probe for determining the U and Th abundances of the Earth. We constructed a model of the Earth in order to evaluate the rate of geologically produced anti-neutrinos (geo-neutrinos) detectable by KamLAND. We found that KamLAND can be used to determine the absolute abundances of U and Th in the Earth with an accuracy sufficient for placing important constraints on Earth's accretional process and succeeding thermal history. The present observation of geo-neutrinos with KamLAND is consistent with our model prediction based on the bulk silicate Earth (BSE) composition within the uncertainty of the measurement. If a neutrino detector were to be built in Hawaii, where effects of the continental crust would be negligible, it could be used to estimate the U and Th content in the lower mantle and the core. Our calculation of the geo-neutrino event rate on the Earth's surface ind...

  7. The Status of KamLAND After Purification

    Science.gov (United States)

    Grant, Christopher

    2010-02-01

    KamLAND is a 1-kton liquid scintillation detector located in the Kamioka underground laboratory, in Japan. KamLAND has provided a precision measurement of δm^221 using reactor anti-neutrinos, and yielded first observational evidence of geologically produced anti-neutrinos. Since April of 2007, the collaboration has been working on the purification of the detector with the goal of observing 862 keV, ^7Be solar neutrinos. Two purification campaigns have concluded, with a total of 5.4 ktons of scintillator circulated through a distillation and nitrogen purge system. The results of purification and the overall background reduction factors will be presented, along with an update of the ^7Be solar neutrino analysis. )

  8. The KamLAND Full-Volume Calibration System

    Energy Technology Data Exchange (ETDEWEB)

    KamLAND Collaboration; Berger, B. E.; Busenitz, J.; Classen, T.; Decowski, M. P.; Dwyer, D. A.; Elor, G.; Frank, A.; Freedman, S. J.; Fujikawa, B. K.; Galloway, M.; Gray, F.; Heeger, K. M.; Hsu, L.; Ichimura, K.; Kadel, R.; Keefer, G.; Lendvai, C.; McKee, D.; O' Donnell, T.; Piepke, A.; Steiner, H. M.; Syversrud, D.; Wallig, J.; Winslow, L. A.; Ebihara, T.; Enomoto, S.; Furuno, K.; Gando, Y.; Ikeda, H.; Inoue, K.; Kibe, Y.; Kishimoto, Y.; Koga, M.; Minekawa, Y.; Mitsui, T.; Nakajima, K.; Nakajima, K.; Nakamura, K.; Owada, K.; Shimizu, I.; Shimizu, Y.; Shirai, J.; Suekane, F.; Suzuki, A.; Tamae, K.; Yoshida, S.; Kozlov, A.; Murayama, H.; Grant, C.; Leonard, D. S.; Luk, K.-B.; Jillings, C.; Mauger, C.; McKeown, R. D.; Zhang, C.; Lane, C. E.; Maricic, J.; Miletic, T.; Batygov, M.; Learned, J. G.; Matsuno, S.; Pakvasa, S.; Foster, J.; Horton-Smith, G. A.; Tang, A.; Dazeley, S.; Downum, K. E.; Gratta, G.; Tolich, K.; Bugg, W.; Efremenko, Y.; Kamyshkov, Y.; Perevozchikov, O.; Karwowski, H. J.; Markoff, D. M.; Tornow, W.; Piquemal, F.; Ricol, J.-S.

    2009-03-05

    We have successfully built and operated a source deployment system for the KamLAND detector. This system was used to position radioactive sources throughout the delicate 1-kton liquid scintillator volume, while meeting stringent material cleanliness, material compatibility, and safety requirements. The calibration data obtained with this device were used to fully characterize detector position and energy reconstruction biases. As a result, the uncertainty in the size of the detector fiducial volume was reduced by a factor of two. Prior to calibration with this system, the fiducial volume was the largest source of systematic uncertainty in measuring the number of antineutrinos detected by KamLAND. This paper describes the design, operation and performance of this unique calibration system.

  9. Testing the solar LMA region with KamLAND data

    Energy Technology Data Exchange (ETDEWEB)

    Bandyopadhyay, Abhijit [Saha Institute of Nuclear Physics, 1/AF, Bidhannagar, Calcutta 700064 (India); Choubey, Sandhya [Scuola Internazionale Superiore di Studi Avanzati I-34014, Trieste (Italy); Goswami, Srubabati [Harish-Chandra Research Institute, Chhatnag Road, Jhunsi, Allahabad 211019 (India); Gandhi, Raj [Harish-Chandra Research Institute, Chhatnag Road, Jhunsi, Allahabad 211019 (India); Roy, D P [Tata Institute of Fundamental Research, Homi Bhabha Road, Mumbai 400005 (India)

    2003-11-01

    We investigate the potential of 3 kiloton-years (kTy) of KamLAND data to further constrain the {delta}m{sup 2} and tan{sup 2}{theta} values compared to those presently allowed by existing KamLAND and global solar data. We study the extent, dependence and characteristics of this sensitivity in and around the two parts of the LMA region that are currently allowed. Our analysis with 3 kTy simulated spectra shows that KamLAND spectrum data by itself can constrain {delta}m{sup 2} with high precision. Combining the spectrum with global solar data further tightens the constraints on allowed values of tan{sup 2}{theta} and {delta}m{sup 2}. We also study the effects of future neutral current data with a total error of 7% from the Sudbury Neutrino Observatory. We find that these future measurements offer the potential of considerable precision in determining the oscillation parameters (specially the mass parameter)

  10. Mantle geoneutrinos in KamLAND and Borexino

    CERN Document Server

    Fiorentini, G; Lisi, E; Mantovani, F; Rotunno, A M

    2012-01-01

    The KamLAND and Borexino experiments have observed, each at ~4 sigma level, signals of electron antineutrinos produced in the decay chains of thorium and uranium in the Earth's crust and mantle (Th and U geoneutrinos). Various pieces of geochemical and geophysical information allow an estimation of the crustal geoneutrino flux components with relatively small uncertainties. The mantle component may then be inferred by subtracting the estimated crustal flux from the measured total flux. To this purpose, we analyze in detail the experimental Th and U geoneutrino event rates in KamLAND and Borexino, including neutrino oscillation effects. We estimate the crustal flux at the two detector sites, using state-of-the-art information about the Th and U distribution on global and local scales. We find that crust-subtracted signals show hints of a residual mantle component, emerging at ~2.4 sigma level by combining the KamLAND and Borexino data. The inferred mantle flux slightly favors scenarios with relatively high Th ...

  11. Testing the solar LMA region with KamLAND data

    CERN Document Server

    Bandyopadhyay, A; Gandhi, R; Goswami, S; Roy, D P; Bandyopadhyay, Abhijit; Choubey, Sandhya; Gandhi, Raj; Goswami, Srubabati

    2003-01-01

    In this paper we investigate the potential of 1 and 3 kiloTon-years(kTy) of KamLAND data to further constrain the $\\Delta m^2$ and $\\tan^2\\theta$ values allowed by the post-SNO NC global solar data. We find that although an energy integrated oscillation to no oscillation event-rate ratio in the range $\\sim$ 0.3-0.8 observed in KamLAND can provide support for the Large-Mixing Angle (LMA) solution, sensitive determination of the oscillation parameters will have to wait until the spectrum data is made available. We study the extent, dependence and characteristics of this sensitivity in and around the LMA region. Our analysis with 3 kTy simulated spectra shows that KamLAND spectrum data by itself can constrain $\\Delta m^2$ with a high precision if the simulation point lies around the LMA best-fit from global solar analysis. For spectra generated at lower values of $\\tan^2\\theta$ or higher values of $\\Delta m^2$, multiple regions become allowed indicating a significantly reduced reconstruction efficiency if the tr...

  12. Solar neutrino oscillation parameters after first KamLAND results

    CERN Document Server

    Fogli, G L; Marrone, A; Montanino, D; Palazzo, A; Rotunno, A M

    2003-01-01

    We analyze the energy spectrum of reactor neutrino events recently observed in the Kamioka Liquid scintillator Anti-Neutrino Detector (KamLAND) and combine them with solar and terrestrial neutrino data, in the context of two- and three-family active neutrino oscillations. In the 2-neutrino case, we find that the solution to the solar neutrino problem at large mixing angle (LMA) is basically split into two sub-regions, that we denote as LMA-I and LMA-II. The LMA-I solution, characterized by lower values of the squared neutrino mass gap, is favored by the global data fit. This picture is not significantly modified in the 3-neutrino mixing case. A brief discussion is given about the discrimination of the LMA-I and LMA-II solutions with future KamLAND data. In both the 2- and 3-neutrino cases, we present a detailed analysis of the post-KamLAND bounds on the oscillation parameters.

  13. CPT Tests: Kaon vs neutrinos

    Energy Technology Data Exchange (ETDEWEB)

    Murayama, Hitoshi

    2003-07-09

    CPT violation has an impressive limit in the neutral kaon system |m(K{sup 0})-m({bar K}{sup 0})| < 10{sup -18} m{sub K} = 0.50 x 10{sup -18} GeV. However, if viewed as a constraint on the mass-squared, the bound appears weak, |m{sup 2}(K{sup 0})-m{sup 2}({bar K}{sup 0})| < 0.25 eV{sup 2}. the authors point out that neutrino oscillation offers better limits on CPT violation in this case. The comparison of solar and rector neutrino results puts the best limit on CPT violation by far, |{Delta}m{sub {nu}}{sup 2}-{Delta}m{sub {rho}}{sup 2}| < 1.3 x 10{sup -3} eV{sup 2} (90% CL).

  14. Disappearing neutrinos at KamLAND suport the case for neutrino mass

    CERN Multimedia

    Johnson, G

    2002-01-01

    Measurements from KamLAND, show that anti-neutrinos emanating from nearby nuclear reactors are "disappearing," which indicates they have mass and can oscillate or change from one type to another (2 pages)

  15. On the origin of the discrepancy between the expected and observed results at KamLAND

    CERN Document Server

    Slad, L M

    2016-01-01

    After an elegant solution of the solar neutrino problem was found on the basis of a hypothesis of semiweak interaction between electron neutrinos and nucleons, a question has appeared about the origin of the difference between the expected results and the ones observed at KamLAND. We argue for significant role of light attenuation in the KamLAND liquid scintillator which has not been taken into account in theoretical calculations of the observability of expected events $\\bar{\

  16. Recent Progress in Lorentz and CPT Violation

    CERN Document Server

    Kostelecky, Alan

    2016-01-01

    This contribution to the CPT'16 meeting briefly highlights some of the recent progress in the phenomenology of Lorentz and CPT violation, with emphasis on research performed at the Indiana University Center for Spacetime Symmetries.

  17. On the measurement of solar neutrino oscillation parameters with KamLAND

    Energy Technology Data Exchange (ETDEWEB)

    Bandyopadhyay, Abhijit; Choubey, Sandhya; Goswami, Srubabati; Petcov, S.T

    2004-02-12

    A new reactor power plant Shika-2, with a power of approximately 4 GW and at a distance of about 88 km from the KamLAND detector is scheduled to start operating in March 2006. We study the impact of the {nu}-bar{sub e} flux from this reactor on the sensitivity of the KamLAND experiment to the solar neutrino oscillation parameters. We present results on prospective determination of {delta}m{sup 2}{sub o} and sin{sup 2}{theta}{sub o} using the combined data from KamLAND and the solar neutrino experiments, including the effect of the Shika-2 contribution to the KamLAND signal and the latest data from the salt enriched phase of the SNO experiment. We find that contrary to the expectations, the addition of the Shika-2 reactor flux does not improve the sin{sup 2}{theta}{sub o} sensitivity of KamLAND, while the ambiguity in {delta}m{sup 2}{sub o} measurement may even increase, as a result of the averaging effect between Kashiwazaki and the Shika-2 reactor contributions to the KamLAND signal.

  18. Update of the solar neutrino oscillation analysis with the 766 Ty KamLAND spectrum

    CERN Document Server

    Bandyopadhyay, A; Goswami, S; Petcov, S T; Roy, D P; Bandyopadhyay, Abhijit; Choubey, Sandhya; Goswami, Srubabati

    2004-01-01

    We investigate the impact of the observed spectral distortion in the 766.3 Ty KamLAND data in sharpening the allowed areas in solar neutrino oscillation parameter space. We study the robustness of the allowed regions and mutual consistency between different data sets by doing two generation neutrino oscillation global fits by removing one of the solar neutrino experiments from the analysis. We also examine the change if any in the bound on $\\theta_{13}$ from a three generation analysis with the inclusion of the new KamLAND data. We find that the precision of $\\Delta m^2_{21}$ improves significantly with the new KamLAND data in both two and three generation analysis but there is still scope for improvement for the precision of $\\theta_{12}$. The combined solar and KamLAND data excludes the high-LMA solution at the 4$\\sigma$ level in a one parameter fit. The maximal mixing solution is disfavoured to a greater extent by the new KamLAND data and the solar + KamLAND combination excludes it at about 6$\\sigma$. We d...

  19. Implications of partially degenerate neutrinos at a high scale in the light of KamLAND and WMAP

    CERN Document Server

    Joshipura, A S; Joshipura, Anjan S.; Mohanty, Subhendra

    2003-01-01

    Electroweak radiative corrections can generate the neutrino (mass)$^2$ difference required for the large mixing angle solution (LMA) to the solar neutrino problem if two of the neutrinos are assumed degenerate at high energy. We test this possibility with the existing experimental knowledge of the low energy neutrino mass and mixing parameters. We derive restrictions on ranges of the high scale mixing matrix elements and obtain predictions for the low energy parameters required in order to get the LMA solution of the solar neutrino problem picked out by KamLAND. We find that in the case of standard model this is achieved only when the (degenerate) neutrino masses lie in the range $(0.7-2) \\eV$ which is at odds with the cosmological limit $m_{\

  20. CPT violation implies violation of Lorentz invariance.

    Science.gov (United States)

    Greenberg, O W

    2002-12-02

    A interacting theory that violates CPT invariance necessarily violates Lorentz invariance. On the other hand, CPT invariance is not sufficient for out-of-cone Lorentz invariance. Theories that violate CPT by having different particle and antiparticle masses must be nonlocal.

  1. An Update on Progress at KamLAND

    CERN Document Server

    Dazeley, S A

    2002-01-01

    The first generation of solar neutrino experiments narrowed the allowed flavor mixing and mass parameter solutions (for nu_e nu_x) to a few isolated regions of sin^2*2*theta - delta M^2 parameter space. Recently, the Small Mixing Angle (SMA) solution, and the ``just so'' solutions have been disfavored by results from Super-Kamiokande and SNO. The Kamioka Liquid scintillator Anti-Neutrino Detector (KamLAND) recently became operational, and is particularly sensitive to the Large Mixing Angle (LMA) region. We believe the background impurity levels in the detector are low enough to conduct a successful experiment. The stability of the central balloon and PMTs has also been confirmed.

  2. Constraints on theta 13 from a three-flavor oscillation analysis of reactor antineutrinos at KamLAND

    NARCIS (Netherlands)

    Gando, A.; et al., [Unknown; Decowski, M.P.

    2011-01-01

    We present new constraints on the neutrino oscillation parameters Δm212, θ12, and θ13 from a three-flavor analysis of solar and KamLAND data. The KamLAND data set includes data acquired following a radiopurity upgrade and amounts to a total exposure of 3.49×1032 target-proton-year. Under the assumpt

  3. Be7 solar neutrino measurement with KamLAND

    Energy Technology Data Exchange (ETDEWEB)

    Gando, A.; Gando, Y.; Hanakago, H.; Ikeda, H.; Inoue, K.; Ishidoshiro, K.; Ishikawa, H.; Kishimoto, Y.; Koga, M.; Matsuda, R.; Matsuda, S.; Mitsui, T.; Motoki, D.; Nakajima, K.; Nakamura, K.; Obata, A.; Oki, A.; Oki, Y.; Otani, M.; Shimizu, I.; Shirai, J.; Suzuki, A.; Tamae, K.; Ueshima, K.; Watanabe, H.; Xu, B. D.; Yamada, S.; Yamauchi, Y.; Yoshida, H.; Kozlov, A.; Takemoto, Y.; Yoshida, S.; Grant, C.; Keefer, G.; McKee, D. W.; Piepke, A.; Banks, T. I.; Bloxham, T.; Freedman, S. J.; Fujikawa, B. K.; Han, K.; Hsu, L.; Ichimura, K.; Murayama, H.; O' Donnell, T.; Steiner, H. M.; Winslow, L. A.; Dwyer, D.; Mauger, C.; McKeown, R. D.; Zhang, C.; Berger, B. E.; Lane, C. E.; Maricic, J.; Miletic, T.; Learned, J. G.; Sakai, M.; Horton-Smith, G. A.; Tang, A.; Downum, K. E.; Tolich, K.; Efremenko, Y.; Kamyshkov, Y.; Perevozchikov, O.; Karwowski, H. J.; Markoff, D. M.; Tornow, W.; Detwiler, J. A.; Enomoto, S.; Heeger, K.; Decowski, M. P.

    2015-11-30

    We report a measurement of the neutrino-electron elastic scattering rate of 862 keV 7Be solar neutrinos based on a 165.4 kt d exposure of KamLAND. The observed rate is 582±94(kt d)₋1, which corresponds to an 862-keV 7Be solar neutrino flux of (3.26±0.52)×109cm₋2s₋1, assuming a pure electron-flavor flux. Comparing this flux with the standard solar model prediction and further assuming three-flavor mixing, a νe survival probability of 0.66±0.15 is determined from the KamLAND data. Lastly, utilizing a global three-flavor oscillation analysis, we obtain a total 7Be solar neutrino flux of (5.82±1.02)×109cm₋2s₋1, which is consistent with the standard solar model predictions.

  4. The solar neutrino problem after the first results from KamLAND

    Energy Technology Data Exchange (ETDEWEB)

    Bandyopadhyay, Abhijit; Choubey, Sandhya; Gandhi, Raj; Goswami, Srubabati; Roy, D.P

    2003-05-01

    The first results from the KamLAND experiment have provided confirmational evidence for the Large Mixing Angle (LMA) Mikheyev-Smirnov-Wolfenstein (MSW) solution to the solar neutrino problem. We do a global analysis of solar and the recently announced KamLAND data (both rate and spectrum) and investigate its effect on the allowed region in the {delta}m{sup 2}-tan{sup 2}{theta} plane. The best-fit from a combined analysis which uses the KamLAND rate plus global solar data comes at {delta}m{sup 2}=6.06x10{sup -5} eV{sup 2} and tan{sup 2}{theta}=0.42, very close to the global solar best-fit, leaving a large allowed region within the global solar LMA contour. The inclusion of the KamLAND spectral data in the global fit gives a best-fit {delta}m{sup 2}=7.17x10{sup -5} eV{sup 2} and tan{sup 2}{theta}=0.43 and constrains the allowed areas within LMA, leaving essentially two allowed zones. Maximal mixing though allowed by the KamLAND data alone is disfavored by the global solar data and remains disallowed at about 3{sigma}. The low {delta}m{sup 2} solution (LOW) is now ruled out at about 5{sigma} with respect to the LMA solution.

  5. Experimental Study Of Terrestrial Electron Anti-neutrinos With Kamland

    CERN Document Server

    Tolich, N R

    2005-01-01

    The analysis presented here uses Kamioka Liquid scintillator Anti-Neutrino Detector (KamLAND) to measure the rate of electron anti-neutrinos, ne&d1;' s , produced from terrestrial 238U and 212Th. 238U and 212Th are thought to be the main heat source driving mantle convection in the Earth, which in turn is responsible for plate tectonics. The total terrestrial 238U and 212Th content has been estimated from Earth models and rock samples from a very small fraction of the Earth. Until now there have been no direct measurements. Since ne&d1;' s have an exceedingly small cross section, they propagate undisturbed in the Earth interior, and their measurement near the Earth surface can be used to gain information on their sources. Based on a total of (2.63 ± 0.19) × 1031 target proton-years (0.506 kton- years), the 90% confidence interval for the total number of terrestrial 238U and 212Th ne&d1;' s detected is 4 to 40. This is consistent with the best models of terrestrial 23...

  6. CPT-Odd resonances in neutrino oscillations

    Science.gov (United States)

    Barger; Pakvasa; Weiler; Whisnant

    2000-12-11

    We consider the consequences for future neutrino factory experiments of small CPT-odd interactions in neutrino oscillations. The nu(&mgr;)-->nu(&mgr;) and nu;(&mgr;)-->nu;(&mgr;) survival probabilities at a baseline L = 732 km can test for CPT-odd contributions at orders of magnitude better sensitivity than present neutrino sector limits. Interference between the CPT-violating interaction and CPT-even mass terms in the Lagrangian can lead to a resonant enhancement of the oscillation amplitude. For oscillations in matter, a simultaneous enhancement of both neutrino and antineutrino oscillation amplitudes is possible.

  7. Omnibus experiment: CPT and CP violation with sterile neutrinos

    Science.gov (United States)

    Loo, K. K.; Novikov, N. Yu; Smirnov, M. V.; Trzaska, W. H.; Wurm, M.

    2016-05-01

    We propose to probe both the CPT and CP violation together with the search for sterile neutrinos in one do-it-all experiment. This omnibus experiment would utilize neutrino oscillometry with large scintillator detectors like LENA, JUNO or RENO-50 and manmade radioactive sources similar to the ones used by the GALLEX experiment. Our calculations indicate that such an experiment is realistic and could be performed in parallel to the main research plan for JUNO, LENA, or RENO-50. Assuming as the starting point the values of the oscillation parameters indicated by the current global fit (in 3 active + 1 sterile scenario) and requiring at least 5 sigma confidence level, we estimate that with the proposed experiment we would be able to detect CPT mass anomalies of the order of 1% or larger.

  8. The CP/T Experiment

    CERN Document Server

    Thomson, G

    1999-01-01

    In this talk I describe a proposed Fermilab Main Injector experiment to carry out a program of measurements on the physics of K^0 mesons. The experiment is designed to maximize the interference between K_L and K_S mesons near their production target, and hence have excellent sensitivity to CP violation in many decay modes. The extremely accurate CP violation measurements we will be able to make will allow us to test CPT symmetry violation with sensitivity at the Planck scale. The experiment will use an RF-separated K^+ beam striking a target at the entrance to a hyperon magnet to make the K^0 beam by charge exchange. The decay region, magnetic spectrometer, electromagnetic calorimeter, and muon detector follow immediately to observe interference between K_L and K_S near the target.

  9. Measurement of Neutrino Oscillation with KamLAND: Evidence of Spectral Distortion

    CERN Document Server

    Araki, T; Enomoto, S; Furuno, K; Ichimura, K; Ikeda, H; Inoue, K; Ishihara, K; Iwamoto, T; Kawashima, T; Kishimoto, Y; Koga, M; Koseki, Y; Maeda, T; Mitsui, T; Motoki, M; Nakajima, K; Ogawa, H; Owada, K; Ricol, J S; Shimizu, I; Shirai, J; Suekane, F; Suzuki, A; Tada, K; Tajima, O; Tamae, K; Tsuda, Y; Watanabe, H; Busenitz, J; Classen, T; Djurcic, Z; Keefer, G; McKinny, K; Mei, D M; Piepke, A; Yakushev, E; Berger, B E; Chan, Y D; Decowski, M P; Dwyer, D A; Freedman, S J; Fu, Y; Fujikawa, B K; Goldman, J; Gray, F; Heeger, K M; Lesko, K T; Luk, K B; Murayama, H; Poon, A W P; Steiner, H M; Winslow, L A; Horton-Smith, G A; Mauger, C; McKeown, R D; Vogel, P; Lane, C E; Miletic, T; Gorham, P W; Guillian, G; Learned, J G; Maricic, J; Matsuno, S; Pakvasa, S; Dazeley, S; Hatakeyama, S; Rojas, A; Svoboda, R; Dieterle, B D; Detwiler, J; Gratta, G; Ishii, K; Tolich, N; Uchida, Y; Batygov, M; Bugg, W; Efremenko, Yu V; Kamyshkov, Yu A; Kozlov, A; Nakamura, Y; Gould, C R; Karwowski, H J; Markoff, D M; Messimore, J A; Nakamura, K; Rohm, R M; Tornow, W; Wendell, R; Young, A R; Chen, M J; Wang, Y F; Piquemal, F

    2005-01-01

    We present an improved measurement of the oscillation between the first two neutrino families based on a 766.3 ton-year exposure of KamLAND to reactor anti-neutrinos. KamLAND observes 258 events with nue-bar energies above 3.4MeV compared to 365.2 events expected in the absence of neutrino oscillation. The confidence level for reactor nue-bar disappearance is now 99.995%. The observed energy spectrum disagrees with the expected spectral shape in the absence of neutrino oscillation at the 99.9% confidence level but agrees with the distortion expected from nue-bar oscillation effects. A two-neutrino oscillation analysis of the KamLAND data gives a best-fit point at DeltaMSq=8.3times10^{-5}eV^2 and tan{^2}theta=0.41. A global analysis of data from KamLAND and solar neutrino experiments yields DeltaMSq=8.2^{+0.6}_{-0.5}times10^{-5}eV^2 and tan^{2}theta =0.40^{+0.09}_{-0.07}, the most precise determination to date.

  10. Update of the solar neutrino oscillation analysis with the 766 Ty KamLAND spectrum

    Energy Technology Data Exchange (ETDEWEB)

    Bandyopadhyay, Abhijit [Saha Institute of Nuclear Physics, 1/AF, Bidhannagar, Calcutta 700 064 (India); Choubey, Sandhya [INFN, Sezione di Trieste, Trieste (Italy) and Scuola Internazionale Superiore di Studi Avanzati, I-34014 Trieste (Italy)]. E-mail: sandhya@he.sissa.it; Goswami, Srubabati [Harish-Chandra Research Institute, Chhatnag Road, Jhusi, Allahabad 211 019 (India); Petcov, S.T. [Scuola Internazionale Superiore di Studi Avanzati, I-34014 Trieste (Italy); INFN, Sezione di Trieste, Trieste (Italy); Institute of Nuclear Research and Nuclear Energy, Bulgarian Academy of Sciences, Sofia (Bulgaria); Roy, D.P. [Abdus Salam International Centre for Theoretical Physics, I-34100 Trieste (Italy); Tata Institute of Fundamental Research, Homi Bhabha Road, Mumbai 400 005 (India)

    2005-02-17

    We investigate the impact of the 766.3 Ty KamLAND spectrum data on the determination of the solar neutrino oscillation parameters. We show that the observed spectrum distortion in the KamLAND experiment firmly establishes {delta}m{sub 21}{sup 2} to lie in the low-LMA solution region. The high-LMA solution is excluded at more than 4{sigma} by the global solar neutrino and KamLAND spectrum data. The maximal solar neutrino mixing is ruled out at 6{sigma} level. The 3{sigma} allowed region in the {delta}m{sub 21}{sup 2}-sin{sup 2}{theta}{sub 12} plane is found to be remarkably stable with respect to leaving out the data from one of the solar neutrino experiments from the global analysis. We perform a three flavor neutrino oscillation analysis of the global solar neutrino and KamLAND spectrum data as well. The 3{sigma} upper limit on sin{sup 2}{theta}{sub 13} is found to be sin{sup 2}{theta}{sub 13}<0.055. We derive predictions for the CC to NC event rate ratio and day-night (D-N) asymmetry in the CC event rate, measured in the SNO experiment, and for the suppression of the event rate in the BOREXINO and LowNu experiments. Prospective high precision measurements of the solar neutrino oscillation parameters are also discussed.

  11. On the Measurement of Solar Neutrino Oscillation Parameters with KamLAND

    CERN Document Server

    Bandyopadhyay, A; Goswami, S; Petcov, S T; Bandyopadhyay, Abhijit; Choubey, Sandhya; Goswami, Srubabati

    2004-01-01

    A new reactor power plant Shika-2, with a power of approximately 4 GW and at a distance of about 88 km from the KamLAND detector is scheduled to start operating in March 2006. We study the impact of the $\\bar\

  12. A compact ultra-clean system for deploying radioactive sources inside the KamLAND detector

    NARCIS (Netherlands)

    Banks, T.I.; Freedman, S.J.; Wallig, J.; Ybarrolaza, N.; Gando, A.; Gando, Y.; Ikeda, H.; Inoue, K.; Kishimoto, Y.; Koga, M.; Mitsui, T.; Nakamura, K.; Shimizu, I.; Shirai, J.; Suzuki, A.; Takemoto, Y.; Tamae, K.; Ueshima, K.; Watanabe, H.; Xu, B.D.; Yoshida, H.; Yoshida, S.; Kozlov, A.; Grant, C.; Keefer, G.; Piepke, A.; Bloxham, T.; Fujikawa, B.K.; Han, K.; Ichimura, K.; Murayama, H.; O'Donnell, T.; Steiner, H.M.; Winslow, L.A.; Dwyer, D.A.; McKeown, R.D.; Zhang, C.; Berger, B.E.; Lane, C.E.; Maricic, J.; Miletic, T.; Batygov, M.; Learned, J.G.; Matsuno, S.; Sakai, M.; Horton-Smith, G.A.; Downum, K.E.; Gratta, G.; Efremenko, Y.; Perevozchikov, O.; Karwowski, H.J.; Markoff, D.M.; Tornow, W.; Heeger, K.M.; Detwiler, J.A.; Enomoto, S.; Decowski, M.P.

    2015-01-01

    We describe a compact, ultra-clean device used to deploy radioactive sources along the vertical axis of the KamLAND liquid-scintillator neutrino detector for purposes of calibration. The device worked by paying out and reeling in precise lengths of a hanging, small-gauge wire rope (cable); an assort

  13. Search for extraterrestrial antineutrino sources with the KamLAND detector

    NARCIS (Netherlands)

    Abe, S.; et al., [Unknown; Decowski, M.P.

    2012-01-01

    We present the results of a search for extraterrestrial electron antineutrinos ( 's) in the energy range 8.3 MeV < Eve < 31.8 MeV using the KamLAND detector. In an exposure of 4.53 kton-year, we identify 25 candidate events. All of the candidate events can be attributed to background, most important

  14. Solving the Solar Neutrino Puzzle with KamLAND and Solar Data

    CERN Document Server

    De Gouvêa, A; Gouv\\^ea, Andr\\'e de

    2001-01-01

    We study what will be learnt about the solar neutrino puzzle and solar neutrino oscillations once the data from the KamLAND reactor neutrino experiment (soon to become available) are combined with those from the current solar neutrino experiments. We find that, in agreement with previous estimates, if the solution to the solar neutrino puzzle falls on the LMA region, KamLAND should be able to ``pin-point'' the right solution with unprecedented accuracy after a few years of data taking. Furthermore, the light side ($\\theta\\pi/4$) at the 95% confidence level (CL) for most of the LMA region allowed by the current data at the 99% CL, while the addition of the KamLAND data need not improve our ability to limit a sterile component in ``solar'' oscillations. If KamLAND does not see an oscillation signal, the solar data would point to the LOW/VAC regions, while the SMA region would still lurk at the two sigma CL, meaning we would probably have to wait for Borexino data in order to finally piece the solar neutrino puz...

  15. Web life: If We Assume

    Science.gov (United States)

    2012-10-01

    The title If We Assume refers to physicists' habit of making back-of-the-envelope calculations, but do not let the allusion to assumptions fool you: there are precious few spherical cows rolling around frictionless surfaces in this corner of the Internet.

  16. $CPT$ violation searches and prospects for LHCb

    CERN Document Server

    van Tilburg, Jeroen

    2015-01-01

    An overview of current experimental bounds on $CPT$ violation in neutral meson mixing is given. New values for the $CPT$ asymmetry in the $B^0$ and $B_s^0$ systems are deduced from BaBar, Belle and LHCb data. With dedicated analyses, LHCb will be able to further improve the bounds on $CPT$ violation in the $D^0$, $B^0$ and $B_s^0$ systems. Since $CPT$ violation implies violation of Lorentz invariance, the observed $CPT$ asymmetry will exhibit sidereal- and boost-dependent variations. Such $CPT$-violating and Lorentz-violating effects are accommodated in the framework of the Standard-Model Extension (SME). The large boost of the neutral mesons produced at LHCb results in a high sensitivity to the corresponding SME coefficients. For the $B^0$ and $B_s^0$ systems, using existing LHCb data, we determine with high precision the SME coefficients that are not varying with sidereal time. With a full sidereal analysis, LHCb will be able to improve the existing SME bounds in the $D^0$, $B^0$ and $B_s^0$ systems by up t...

  17. KamLAND Sensitivity to Neutrinos from Pre-Supernova Stars

    CERN Document Server

    Asakura, K; Gando, Y; Hachiya, T; Hayashida, S; Ikeda, H; Inoue, K; Ishidoshiro, K; Ishikawa, T; Ishio, S; Koga, M; Matsuda, S; Mitsui, T; Motoki, D; Nakamura, K; Obara, S; Oura, T; Shimizu, I; Shirahata, Y; Shirai, J; Suzuki, A; Tachibana, H; Tamae, K; Ueshima, K; Watanabe, H; Xu, B D; Kozlov, A; Takemoto, Y; Yoshida, S; Fushimi, K; Piepke, A; Banks, T I; Berger, B E; Fujikawa, B K; O'Donnell, T; Learned, J G; Maricic, J; Matsuno, S; Sakai, M; Winslow, L A; Efremenko, Y; Karwowski, H J; Markoff, D M; Tornow, W; Detwiler, J A; Enomoto, S; Decowski, M P

    2015-01-01

    In the late stages of nuclear burning for massive stars ($M$> 10 $M_{sun}$), the production of neutrino-antineutrino pairs through various processes becomes the dominant mechanism of stellar cooling. As the star evolves, the energy of these neutrinos increases and in the days preceding the supernova a significant fraction of emitted electron anti-neutrinos exceeds the threshold for inverse beta decay on free hydrogen. This is the golden channel for liquid scintillator detectors because the coincidence signature allows for significant reductions in background signals. We find that the kiloton-scale liquid scintillator detector KamLAND can detect these pre-supernova neutrinos from a star with a mass of 25 $M_{sun}$ at a distance less than 660 pc with 3{\\sigma} significance before the supernova. This limit is dependent on the neutrino mass hierarchy and background levels. KamLAND takes data continuously and can provide an alarm for supernovae to the community.

  18. Measurement of the 8B solar neutrino flux with the KamLAND liquid scintillator detector

    NARCIS (Netherlands)

    Abe, S.; et al., [Unknown; Decowski, M.P.

    2011-01-01

    We report a measurement of the neutrino-electron elastic scattering rate from 8B solar neutrinos based on a 123 kton-day exposure of KamLAND. The background-subtracted electron recoil rate, above a 5.5-MeV analysis threshold is 1.49 ± 0.14(stat) ± 0.17(syst) events per kton-day. Interpreted as due t

  19. Searches for sterile component with solar neutrinos and KamLAND

    CERN Document Server

    De Holanda, P C

    2002-01-01

    Possible mixing of the active and sterile neutrinos has been considered both in the single Delta m^2 approximation and in the case of more than one Delta m^2. We perform global fit of the available solar neutrino data with free boron neutrino flux in the single Delta m^2 context. The best fit value corresponds to zero fraction of sterile component eta=0. We get the upper bounds: eta<0.26 (0.64) at 1\\sigma (3 sigma). Due to degeneracy of parameters no one individual experiment restricts eta. The bound appears as an interplay of the SNO and Gallium as well as SuperKamiokande data. Future measurements of the NC/CC ratio at SNO can strengthen the bound down to eta<0.5 (3 sigma). If KamLAND confirms the LMA solution with its best fit point a combined analysis of the KamLAND and solar neutrino results will lead to eta<0.19 (0.56) at 1 sigma (3 sigma). We find that existence of sterile neutrino can explain the intermediate value of suppression of the KamLAND event rate: R_{KL}~0.75-0.90 in the case when mor...

  20. CPT and Decoherence in Quantum Gravity

    CERN Document Server

    Mavromatos, N E

    2007-01-01

    In this review, I first discuss briefly some theoretical motivations for potential Lorentz Violation and deviation from ordinary quantum mechanical behavior (decoherence) of field theoretic systems in the background of some quantum gravity (QG) models. Both types of effects lead to CPT violation, but they can be disentangled experimentally. I, then, proceed to a description of precision tests of CPT symmetry using neutral and charged Kaons, which are of direct relevance to the main theme of this conference. I emphasize the potentially unique r\\^ole of neutral meson factories in providing ``smoking-gun'' evidence of some QG-decoherence models in which the CPT quantum mechanical operator is not well defined. This is achieved by means of potential observations of QG-induced modifications of the pertinent Einstein-Podolsky-Rosen (EPR) particle correlations.

  1. Measurements of CPT Violation at LHCb

    CERN Document Server

    INSPIRE-00260865

    2017-01-01

    Recent measurements of CPT violation and Lorentz symmetry breaking in $B^0-\\bar{B}^0$ mixing and $B^0_s-\\bar{B}^0_s$ mixing, obtained from data taken by the LHCb experiment, are highlighted. The results are expressed in terms of the Standard-Model Extension (SME) coefficients, which incorporate both CPT and Lorentz violation. Due to the large boost of the $B$ mesons at LHCb, the SME coefficients can be determined with high precision. The bounds on these coefficients are improved significantly compared to previous measurements.

  2. First observation of beryllium-7 solar neutrinos with KamLAND

    Science.gov (United States)

    Keefer, Gregory J.

    2009-09-01

    The international KamLAND collaboration operates a 1 kton liquid scintillation detector in the Kamioka mine in Gifu, Japan. KamLAND's main scientific results are the precision measurement of the solar Dm 2 12 = 7.58[Special characters omitted.] (stat) [Special characters omitted.] (syst) and tan 2 [straight theta] 12 = 0.56[Special characters omitted.] (stat) [Special characters omitted.] (syst) utilizing reactor n e and first evidence for the observation of geologically produced anti-neutrinos. In an effort to extend KamLAND's scientific reach, extensive research has been performed on preparing a spectroscopic measurement of 7 Be solar n e s. This work provides the first inclusive analysis of KamLAND's backgrounds below 1 MeV. 85 Kr and 210 Pb, dissolved in KamLAND liquid scintillator, were found to be the dominant source of low energy backgrounds. The concentration of these ultra-trace contaminants were determined to be 10 -20 g/g. This is more than 6 orders of magnitude lower than commercially available ultra-pure liquids. To attain a signal-to-background ratio suitable for the detection of 7 Be solar n e s, the concentration of these contaminants had to be reduced by 5 orders of magnitude. A comprehensive study of 210 Pb removal was undertaken over the course of this thesis. This work further covers techniques for the removal of 220 Rn, 222 Rn and their daughter nuclei from liquid scintillator at concentrations of 10^-18 g/g. Purification techniques studied in this work include water extraction, isotope exchange, adsorption, and distillation. These laboratory studies guided the design and implementation of a large scale purification system in the Kamioka mine. The purification system's design and operation is discussed in detail as well as specific experiments devised to control scintillator quality and radio-purity. The purification system's effectiveness in removing radioactive trace impurities is analyzed in detail. The total scintillator purified over two

  3. Testing Lorentz and CPT invariance with neutrinos

    CERN Document Server

    Diaz, Jorge S

    2016-01-01

    Neutrino experiments can be considered sensitive tools to test Lorentz and CPT invariance. Taking advantage of the great variety of neutrino experiments, including neutrino oscillations, weak decays, and astrophysical neutrinos, the generic experimental signatures of the breakdown of these fundamental symmetries in the neutrino sector are presented.

  4. Maturational delay in ADHD: Evidence from CPT

    Directory of Open Access Journals (Sweden)

    Itai eBerger

    2013-10-01

    Full Text Available While data from behavioural, neuropsychological, and brain studies suggested that Attention-Deficit/Hyperactivity Disorder (ADHD is related to a developmental lag that reduces with age, other studies have proposed that ADHD represents a deviant brain function. The present study used a cross-sectional approach to examine whether ADHD children show a developmental delay in cognitive performance measured by continuous performance test (CPT. We thus compared six age groups of ADHD children (N=559 and their unaffected peers (N=365, aged 6-11, in four parameters of MOXO-CPT performance: Attention, Timing, Hyperactivity and Impulsivity. Results have shown that despite improvement in CPT performance with age, ADHD children continued to demonstrate impaired performance as compared to controls. In most parameters, CPT performance of ADHD children matched that of 1-3 years younger normal controls, with a delay most prominent in older children. However, in the Hyperactivity parameter, ADHD children’s performance resembled that of much younger healthy children, with almost no evidence for a developmental catch up. This study suggests that while some cognitive functions develop slower but normally, other functions (e.g., inhibitory control show a different sequel.

  5. CPT Results from KTeV

    Energy Technology Data Exchange (ETDEWEB)

    Hogan Nguyen

    2002-01-14

    I present several preliminary measurements from KTeV of the fundamental neutral K parameters, and their implications for CPT violation. A new limit is given on the sidereal time dependence of {phi}{sub +-}. The results are based on data collected in 1996-97.

  6. Effects of cannabinoid receptor 1 (brain) on lipid accumulation by transcriptional control of CPT1A and CPT1B.

    Science.gov (United States)

    Zhang, Y-F; Yuan, Z-Q; Song, D-G; Zhou, X-H; Wang, Y-Z

    2014-02-01

    CB1 (also known as CNR1), a main receptor for cannabinoids acting at PPARs, can enhance fat deposition. Carnitine palmitoyltransferase-1 (CPT1), an enzyme responsible for the transport of long-chain fatty acids for β-oxidation, is closely related to fat deposition. Whether CB1 can regulate intramuscular adipocytes lipid accumulation through regulation of CPT1 is unclear. Based on the investigation of tissue- and breed-specific CPT1A and CPT1B mRNA expression levels in Jinhua and Landrace pigs, we studied the effects of CB1 on lipid accumulation and CPT1B expression by treating porcine intramuscular adipocytes with CB1 antagonist Δ9-THC and antagonist SR141716. Results showed that muscle CPT1 mRNA was expressed at higher levels in the longissimus dorsi and subcutaneous fat. Liver CPT1A mRNA expression levels were higher in the pancreas, duodenum and liver. Compared with Landrace pigs, CPT1A and CPT1B in the longissimus dorsi of Jinhua pigs were significantly higher and positively correlated with intramuscular fat content. However, for subcutaneous fat, CPT1 levels were significantly lower and negatively correlated with body fat percentage. Δ9-THC significantly increased CB1 mRNA levels and lipid accumulation but decreased CPT1A and CPT1B mRNA levels. Conversely, SR141716 reduced CB1 mRNA levels but increased CPT1A and CPT1B mRNA levels, resulting in decreased lipid accumulation. The CPT1 antagonist etomoxir did not affect CB1 expression, suggesting that CB1 is likely upstream of CPT1A and CPT1B. Meanwhile, PPARA expression was greatly decreased when CPT1A and CPT1B were inhibited and enhanced when CPT1A and CPT1B were activated. Taken together, these data indicate that CB1 can affect intramuscular fat deposition by regulating both CPT1A and CPT1B mRNA expression, with the PPARA signal pathway likely playing a major role in this process.

  7. LMA MSW solution of the solar neutrino problem and first KamLAND results

    CERN Document Server

    De Holanda, P C

    2003-01-01

    The first KamLAND results are in a very good agreement with the predictions made on the basis of the solar neutrino data and the LMA realization of the MSW mechanism. We perform a combined analysis of the KamLAND (rate, spectrum) and the solar neutrino data with a free boron neutrino flux f_B. The best fit values of neutrino parameters are Delta m^2 = 7.3e-5 eV^2, tg^2 theta = 0.41 and f_B = 1.05 with the 1 sigma intervals: Delta m^2 = (6.2 - 8.4)e-5 eV^2, tg^2 theta = 0.33 - 0.54. We find the 3 sigma upper bounds: Delta m^2 4e-5 eV^2. At 99% C.L. the KamLAND spectral result splits the LMA region into two parts with the preferred one at Delta m^2 < 1e-4 eV^2. The higher Delta m^2 region is accepted at about 2 sigma level. We show that effects of non-zero 13-mixing, sin^2 theta_{13} < 0.04, are small leading to slight improvement of the fit in higher Delta m^2 region. In the best fit point we predict for SNO: CC/NC = 0.33 +0.05-0.03 and A_{DN}(SNO) = 2.8+-0.8 % (68% C.L.), and A_{DN}(SNO) < 9 % at th...

  8. Determination of the age of the earth from Kamland measurement of geo-neutrinos

    OpenAIRE

    Mohanty, Subhendra

    2003-01-01

    The low energy component of the antineutrino spectrum observed in the recent Kamland experiment has significant contribution from the radioactive decay of $^{238}U$ and $^{232}Th$ in the crust and mantle of the earth. By taking the ratio of the antineutrino events obeserved in two different energy ranges we can determine the present value $[Th/U]$ independent of the U,Th distribution in the earth. Comparing with the r-process initial value of $[Th/U]_0$ we determine the age of the earth as a ...

  9. CPT Violation and Decoherence in Quantum Gravity

    CERN Document Server

    Mavromatos, Nick E

    2009-01-01

    In this brief review I discuss ways and tests of CPT-Violation in the context of quantum gravity theories with space-time foam vacua, which entail quantum decoherence of matter propagating in such backgrounds. I cover a wide variety of sensitive probes, ranging from cosmic neutrinos to meson factories. I pay particular emphasis on associating the latter with specific, probably unique ("smoking-gun"), effects of this type of CPT Violation, related to a modification of Einstein-Podolsky-Rosen (EPR) correlations in the entangled states of the relevant neutral mesons. I also present some semi-microscopic estimates of these latter effects, in the context of a specific string-inspired model of space-time foam ("D-particle foam").

  10. LEP tests of CPT in B oscillations

    CERN Document Server

    Jimack, Martin Paul

    1999-01-01

    A review of LEP tests of CPT in the B system is presented. There are published results from OPAL and preliminary results from DELPHI. The combined result for the parameter Im delta /sub B/, determined in B oscillations, is Im delta /sub B/=-0.016+or-0.012. A test of the lifetime difference between b and b hadrons is also presented. (8 refs).

  11. Quantum Gravity, CPT symmetry and Entangled States

    CERN Document Server

    Mavromatos, Nick E

    2008-01-01

    There may unique ("smoking-gun") signatures of the breakdown of CPT symmetry, induced in some models of Quantum Gravity entailing decoherence for quantum matter. Such effects can be observed in entangled states of neutral mesons via modifications of the respective Einstein-Podolsky-Rosen (EPR) correlators ("omega"-effect). In the talk I discuss experimental signatures and bounds of the omega-effect in Phi- and B-factories, and argue that the effect might be falsifiable at the next generation facilities.

  12. Setting Limits On The Power Of A Geo-reactor With Kamland Detector

    CERN Document Server

    Maricic, J

    2005-01-01

    The Earth's magnetic field has existed for at least 3 billion years with high and on average stable intensity, though with many fluctuations and reversals. One of the models, albeit rather controversial, proposed as the energy source of the Earth's magnetic field is a natural nuclear reactor inside the Earth's core [1] and [2]. This author maintains that this is the only model that generates sufficient power to energize the geo-magnetic field for 3 billion years. Even more, the reactor's ability to produce variable power levels including stops and restarts in its operations, provides a viable explanation, according to [2], for the random reversals of the geo-magnetic field that have been recorded numerous times during the Earth's history. In this study, Kamioka Liquid scintillator Anti-Neutrino Detector (KamLAND) is used to set limits on the power of the putative geo-reactor. KamLAND is designed to detect anti-neutrinos from reactors around Japan, and thus can make a direct measurement of the anti-neutrino ra...

  13. Statistically improved Analysis of Neutrino Oscillation Data with the latest KamLAND result

    CERN Document Server

    Aliani, P; Torrente-Lujan, E

    2005-01-01

    We present an updated analysis of all available solar and reactor neutrino data, emphasizing in particular the totality of the KamLAND (314d live time) results and including for the first time the solar $SNO$ (391d live time, phase II NaCl-enhanced) spectrum data. As a novelty of the statistical analysis, we study the variability of the KamLand results with respect the use of diverse statistics. A new statistic, not used before is proposed. Moreover, in the analysis of the SNO spectrum a novel technique is used in order to include full correlated errors among bins. Combining all data, we obtain the following best-fit parameters: we determine individual neutrino mixing parameters and their errors $ \\Delta m^2= 8.2\\pm 0.08\\times 10^{-5} \\eV^2,\\quad \\tan^2\\theta= 0.50^{+0.12}_{-0.07}.$ The impact of these results is discussed. We also estimate the individual elements of the neutrino mass matrix. In the framework of three neutrino oscillations we obtain the mass matrix: \\begin{eqnarray}M&=& eV \\pmatrix{1....

  14. Prospects of probing $\\theta_{13}$ and neutrino mass hierarchy by Supernova Neutrinos in KamLAND

    CERN Document Server

    Bandyopadhyay, A; Goswami, S; Kar, K; Bandyopadhyay, Abhijit; Choubey, Sandhya; Goswami, Srubabati; Kar, Kamales

    2003-01-01

    In this paper we study the physics potential of the KamLAND detector in probing neutrino oscillation parameters through observation of supernova neutrinos. In particular, we discuss the possibilities of probing the mixing angle $\\theta_{13}$ and determining the sign of $\\Delta m^2_{32}$ from the total charged current(CC) event rates on the proton and $^{12}{C}$ target, as well as from the CC spectra. We discuss the chances of probing the earth matter effect induced modulations from the observation of CC spectra in the different CC reactions in KamLAND and find the volume required to get a statistically significant signature of the earth matter effect in different energy bins. We also calculate the event rates expected in the neutral current (NC) reactions on Carbon and free proton and investigate if the charged current to neutral current ratios, which are free of the absolute luminosity uncertainty in the supernova neutrino fluxes, can be useful in probing the oscillation parameters.

  15. Study of the Production of Radioactive Isotopes through Cosmic Muon Spallation in KamLAND

    Energy Technology Data Exchange (ETDEWEB)

    KamLAND Collaboration; Abe, S.; Enomoto, S.; Furuno, K.; Gando, Y.; Ikeda, H.; Inoue, K.; Kibe, Y.; Kishimoto, Y.; Koga, M.; Minekawa, Y.; Mitsui, T.; Nakajima, K.; Nakajima, K.; Nakamura, K.; Nakamura, M.; Shimizu, I.; Shimizu, Y.; Shirai, J.; Suekane, F.; Suzuki, A.; Takemoto, Y.; Tamae, K.; Terashima, A.; Watanabe, H.; Yonezawa, E.; Yoshida, S.; Kozlov, A.; Murayama, H.; Busenitz, J.; Classen, T.; Grant, C.; Keefer, G.; Leonard, D. S.; McKee, D.; Piepke, A.; Banks, T. I.; Bloxham, T.; Detwiler, J. A.; Freedman, S. J.; Fujikawa, B. K.; Gray, F.; Guardincerri, E.; Hsu, L.; Ichimura, K.; Kadel, R.; Lendvai, C.; Luk, K.-B.; O' Donnell, T.; Steiner, H. M.; Winslow, L. A.; Dwyer, D. A.; Jillings, C.; Mauger, C.; McKeown, R. D.; Vogel, P.; Zhang, C.; Berger, B. E.; Lane, C. E.; Maricic, J.; Miletic, T.; Batygov, M.; Learned, J. G.; Matsuno, S.; Pakvasa, S.; Foster, J.; Horton-Smith, G. A.; Tang, A.; Dazeley, S.; Downum, K. E.; Gratta, G.; Tolich, K.; Bugg, W.; Efremenko, Y.; Kamyshkov, Y.; Perevozchikov, O.; Karwowski, H. J.; Markoff, D. M.; Tornow, W.; Heeger, K. M.; Piquemal, F.; Ricol, J.-S.; Decowski, M. P.

    2009-06-30

    Radioactive isotopes produced through cosmic muon spallation are a background for rare event detection in {nu} detectors, double-beta-decay experiments, and dark-matter searches. Understanding the nature of cosmogenic backgrounds is particularly important for future experiments aiming to determine the pep and CNO solar neutrino fluxes, for which the background is dominated by the spallation production of {sup 11}C. Data from the Kamioka Liquid scintillator Anti-Neutrino Detector (KamLAND) provides valuable information for better understanding these backgrounds, especially in liquid scintillator, and for checking estimates from current simulations based upon MUSIC, FLUKA, and Geant4. Using the time correlation between detected muons and neutron captures, the neutron production yield in the KamLAND liquid scintillator is measured to be (2.8 {+-} 0.3) x 10{sup -4} n/({mu} {center_dot} (g/cm{sup 2})). For other isotopes, the production yield is determined from the observed time correlation related to known isotope lifetimes. We find some yields are inconsistent with extrapolations based on an accelerator muon beam experiment.

  16. KamLAND SENSITIVITY TO NEUTRINOS FROM PRE-SUPERNOVA STARS

    Energy Technology Data Exchange (ETDEWEB)

    Asakura, K.; Gando, A.; Gando, Y.; Hachiya, T.; Hayashida, S.; Ikeda, H.; Inoue, K.; Ishidoshiro, K.; Ishikawa, T.; Ishio, S.; Koga, M.; Matsuda, S.; Mitsui, T.; Motoki, D.; Nakamura, K.; Obara, S.; Oura, T.; Shimizu, I.; Shirahata, Y.; Shirai, J. [Research Center for Neutrino Science, Tohoku University, Sendai 980-8578 (Japan); Collaboration: KamLAND Collaboration; and others

    2016-02-10

    In the late stages of nuclear burning for massive stars (M > 8 M{sub ⊙}), the production of neutrino–antineutrino pairs through various processes becomes the dominant stellar cooling mechanism. As the star evolves, the energy of these neutrinos increases and in the days preceding the supernova a significant fraction of emitted electron anti-neutrinos exceeds the energy threshold for inverse beta decay on free hydrogen. This is the golden channel for liquid scintillator detectors because the coincidence signature allows for significant reductions in background signals. We find that the kiloton-scale liquid scintillator detector KamLAND can detect these pre-supernova neutrinos from a star with a mass of 25 M{sub ⊙} at a distance less than 690 pc with 3σ significance before the supernova. This limit is dependent on the neutrino mass ordering and background levels. KamLAND takes data continuously and can provide a supernova alert to the community.

  17. A Monte Carlo approach to Beryllium-7 solar neutrino analysis with KamLAND

    Science.gov (United States)

    Grant, Christopher Peter

    Terrestrial measurements of neutrinos produced by the Sun have been of great interest for over half a century because of their ability to test the accuracy of solar models. The first solar neutrinos detected with KamLAND provided a measurement of the 8B solar neutrino interaction rate above an analysis threshold of 5.5 MeV. This work describes efforts to extend KamLAND's detection sensitivity to solar neutrinos below 1 MeV, more specifically, those produced with an energy of 0.862 MeV from the 7Be electron-capture decay. Many of the difficulties in measuring solar neutrinos below 1 MeV arise from backgrounds caused abundantly by both naturally occurring, and man-made, radioactive nuclides. The primary nuclides of concern were 210Bi, 85Kr, and 39Ar. Since May of 2007, the KamLAND experiment has undergone two separate purification campaigns. During both campaigns a total of 5.4 ktons (about 6440 m3) of scintillator was circulated through a purification system, which utilized fractional distillation and nitrogen purging. After the purification campaign, reduction factors of 1.5 x 103 for 210Bi and 6.5 x 10 4 for 85Kr were observed. The reduction of the backgrounds provided a unique opportunity to observe the 7Be solar neutrino rate in KamLAND. An observation required detailed knowledge of the detector response at low energies, and to accomplish this, a full detector Monte Carlo simulation, called KLG4sim, was utilized. The optical model of the simulation was tuned to match the detector response observed in data after purification, and the software was optimized for the simulation of internal backgrounds used in the 7Be solar neutrino analysis. The results of this tuning and estimates from simulations of the internal backgrounds and external backgrounds caused by radioactivity on the detector components are presented. The first KamLAND analysis based on Monte Carlo simulations in the energy region below 2 MeV is shown here. The comparison of the chi2 between the null

  18. CP and CPT tests with the KLOE detector

    CERN Document Server

    Ambrosino, F; Antonelli, M; Bacci, C; Beltrame, P; Bencivenni, G; Bertolucci, Sergio; Bini, C; Bloise, C; Bocci, V; Bossi, F; Bowring, D; Branchini, P; Caloi, R; Campana, P; Capon, G; Capussela, T; Cera, F; Chi, S; Chiefari, G; Ciambrone, P; Conetti, S; De Lucia, E; De Santis, A; De Simone, P; De Zorzi, G; Dell'Agnello, S; Denig, A; Di Domenico, A; Di Donato, C; Di Falco, S; Di Micco, B; Doria, A; Dreucci, M; Fe, G; Ferrari, A; Ferrer, M L; Finocchiaro, G; Fiore, S; Forti, C; Franzini, P; Gatti, C; Gauzzi, P; Giovannella, S; Gorini, E; Graziani, E; Incagli, M; Kluge, W; Kulikov, V; Lacava, F; Lanfranchi, G; Lee-Franzini, J; Leone, D; Martini, M; Massarotti, P; Mei, W; Meola, S; Miscetti, S; Moulson, M; Müller, S; Murtas, F; Napolitano, M; Nguyen, F; Palutan, M; Pasqualucci, E; Passeri, A; Patera, V; Perfetto, F; Pontecorvo, L; Primavera, M; San, P; Santovetti, E; Saracino, G; Sciascia, B; Sciubba, A; Scuri, F; Sfiligoi, I; Spadaro, T; Testa, M; Tortora, L; Valente, P; Valeriani, B; Venanzoni, G; Veneziano, Stefano; Ventura, A; Versaci, R; Xu, G

    2006-01-01

    Neutral kaons provide one of the most sensitive system to CP and CPT violation. Tests on CP, CPT and quantum mechanics have been performed at KLOE operating at the DAFNE e+e- collider. Results on the quantum interference in the channel phi-> KSKL ->pi+pi-pi+pi-, the measurement of the BR(KL ->pi+pi-) and the related CP violating parameter epsilon are presented. Using the Bell-Steinberger relation, CPT violating parameters have been also obtained

  19. Neutrino Oscillations, Lorentz/CPT Violation, and Dark Energy

    CERN Document Server

    Ando, Shin'ichiro; Mocioiu, Irina

    2009-01-01

    If dark energy (DE) couples to neutrinos, then there may be apparent violations of Lorentz/CPT invariance in neutrino oscillations. The DE-induced Lorentz/CPT violation takes a specific form that introduces neutrino oscillations that are energy independent, differ for particles and antiparticles, and can lead to novel effects for neutrinos propagating through matter. We show that ultra-high-energy neutrinos may provide one avenue to seek this type of Lorentz/CPT violation in \

  20. CP violation: Dalitz interference, CPT and FSI

    CERN Document Server

    Nogueira, J H Alvarenga; Cavalcante, A B R; Frederico, T; Lourenço, O

    2015-01-01

    Resonances and final state interactions (FSI) play a role in the formation of CP violation (CPV) constrained by CPT invariance. We provide a general formulation of CPV including resonances and FSI starting from the CPT constraint. Our discussion is elaborated within a simple $B$ decay model with the $\\rho$ and $f_0(980)$ resonances plus a non resonant background including the $\\pi\\pi \\to KK$ coupled amplitude. We consider few illustrative examples to show the interference patterns appearing in the CP asymmetry, namely, that from the $\\rho$ resonance plus a non-resonant amplitude, and that from the interference of the $\\rho$ and $f_0(980)$ resonances. We perform the fit of the CP asymmetry for the charmless three-body $B^\\pm$ decay channel $B^{\\pm}\\to \\pi^{\\pm} \\pi^+\\pi^-$ and obtain as outcome the $B^{\\pm}\\to \\pi^{\\pm} K^+K^-$ for $\\pi\\pi$ channel asymmetry in the mass region below $1.6$~GeV in fair agreement with the new data LHCb data. Analogously, we also describe the CP asymmetry of the $B^\\pm\\to K^\\pm\\pi...

  1. On the search for CPT violation in the leptonic sector by means of neutrino oscillometry

    CERN Document Server

    Smirnov, Michail V; Novikov, Yuri N; Trzaska, Wladyslaw H; Wurm, Michael

    2015-01-01

    The investigation of the oscillation pattern induced by the sterile neutrinos might, at the same time, allow to probe CPT violation in the leptonic sector. We propose to use a large scintillation detector like JUNO or LENA to detect electron neutrinos and electron antineutrinos from MCi beta decay or electron capture sources similar to the ones used by GALLEX/GNO and SAGE experiments. Our calculations indicate that such an experiment is realistic and could be performed in parallel to the current research plans for JUNO and LENA. Requiring at least 5 sigma confidence level and assuming the values of the oscillation parameters indicated by the current global fit, we would be able to detect CPT anomalies of the order of 0.5% or larger.

  2. Testing Lorentz invariance and CPT conservation with NuMI neutrinos in the MINOS near detector.

    Science.gov (United States)

    Adamson, P; Andreopoulos, C; Arms, K E; Armstrong, R; Auty, D J; Ayres, D S; Baller, B; Barr, G; Barrett, W L; Becker, B R; Belias, A; Bernstein, R H; Bhattacharya, D; Bishai, M; Blake, A; Bock, G J; Boehm, J; Boehnlein, D J; Bogert, D; Bower, C; Buckley-Geer, E; Cavanaugh, S; Chapman, J D; Cherdack, D; Childress, S; Choudhary, B C; Coleman, S J; Culling, A J; de Jong, J K; Diwan, M V; Dorman, M; Dytman, S A; Escobar, C O; Evans, J J; Falk Harris, E; Feldman, G J; Frohne, M V; Gallagher, H R; Goodman, M C; Gouffon, P; Gran, R; Grashorn, E W; Grossman, N; Grzelak, K; Habig, A; Harris, D; Harris, P G; Hartnell, J; Hatcher, R; Heller, K; Himmel, A; Holin, A; Hylen, J; Irwin, G M; Ishitsuka, M; Jaffe, D E; James, C; Jensen, D; Kafka, T; Kasahara, S M S; Kim, J J; Koizumi, G; Kopp, S; Kordosky, M; Koskinen, D J; Kreymer, A; Kumaratunga, S; Lang, K; Ling, J; Litchfield, P J; Litchfield, R P; Loiacono, L; Lucas, P; Ma, J; Mann, W A; Marshak, M L; Marshall, J S; Mayer, N; McGowan, A M; Meier, J R; Messier, M D; Metelko, C J; Michael, D G; Miller, J L; Miller, W H; Mishra, S R; Moore, C D; Morfín, J; Mualem, L; Mufson, S; Murgia, S; Musser, J; Naples, D; Nelson, J K; Newman, H B; Nichol, R J; Nicholls, T C; Ochoa-Ricoux, J P; Oliver, W P; Ospanov, R; Paley, J; Paolone, V; Para, A; Patzak, T; Pavlović, Z; Pawloski, G; Pearce, G F; Peck, C W; Petyt, D A; Pittam, R; Plunkett, R K; Rahaman, A; Rameika, R A; Raufer, T M; Rebel, B; Reichenbacher, J; Rodrigues, P A; Rosenfeld, C; Rubin, H A; Sanchez, M C; Saoulidou, N; Schneps, J; Schreiner, P; Shanahan, P; Smart, W; Sousa, A; Speakman, B; Stamoulis, P; Strait, M; Tagg, N; Talaga, R L; Tavera, M A; Thomas, J; Thompson, J; Thomson, M A; Thron, J L; Tinti, G; Tzanakos, G; Urheim, J; Vahle, P; Viren, B; Watabe, M; Weber, A; Webb, R C; Wehmann, A; West, N; White, C; Wojcicki, S G; Yang, T; Zois, M; Zhang, K; Zwaska, R

    2008-10-10

    A search for a sidereal modulation in the MINOS near detector neutrino data was performed. If present, this signature could be a consequence of Lorentz and CPT violation as predicted by the effective field theory called the standard-model extension. No evidence for a sidereal signal in the data set was found, implying that there is no significant change in neutrino propagation that depends on the direction of the neutrino beam in a sun-centered inertial frame. Upper limits on the magnitudes of the Lorentz and CPT violating terms in the standard-model extension lie between 10(-4) and 10(-2) of the maximum expected, assuming a suppression of these signatures by a factor of 10(-17).

  3. Testing Lorentz Invariance and CPT Conservation with NuMI Neutrinos in the MINOS Near Detector

    CERN Document Server

    Adamson, P; Arms, K E; Armstrong, R; Auty, D J; Ayres, D S; Baller, B; Barr, G; Barrett, W L; Becker, B R; Belias, A; Bernstein, R H; Bhattacharya, D; Bishai, M; Blake, A; Bock, G J; Böhm, J; Böhnlein, D J; Bogert, D; Bower, C; Buckley-Geer, E; Cavanaugh, S; Chapman, J D; Cherdack, D; Childress, S; Choudhary, B C; Coleman, S J; Culling, A J; De Jong, J K; Diwan, M V; Dorman, M; Dytman, S A; Escobar, C O; Evans, J J; Falk-Harris, E; Feldman, G J; Frohne, M V; Gallagher, H R; Goodman, M C; Gouffon, P; Gran, R; Grashorn, E W; Grossman, N; Grzelak, K; Habig, A; Harris, D; Harris, P G; Hartnell, J; Hatcher, R; Heller, K; Himmel, A; Holin, A; Hylen, J; Irwin, G M; Ishitsuka, M; Jaffe, D E; James, C; Jensen, D; Kafka, T; Kasahara, S M S; Kim, J J; Koizumi, G; Kopp, S; Kordosky, M; Koskinen, D J; Kreymer, A; Kumaratunga, S; Lang, K; Ling, J; Litchfield, P J; Litchfield, R P; Loiacono, L; Lucas, P; Ma, J; Mann, W A; Marshak, M L; Marshall, J S; Mayer, N; McGowan, A M; Meier, J R; Messier, M D; Metelko, C J; Michael, D G; Miller, J L; Miller, W H; Mishra, S R; Moore, C D; Morfn, J; Mualem, L; Mufson, S; Murgia, S; Musser, J; Naples, D; Nelson, J K; Newman, i H B; Nichol, R J; Nicholls, T C; Ochoa-Ricoux, J P; Oliver, W P; Ospanov, R; Paley, J; Paolone, V; Para, A; Patzak, T; Pavlovi, Z; Pawloski, G; Pearce, G F; Peck, C W; Petyt, cD A; Pittam, R; Plunkett, R K; Rahaman, A; Rameika, R A; Raufer, T M; Rebel, B; Reichenbacher, J; Rodrigues, P A; Rosenfeld, C; Rubin, H A; Sanchez, M C; Saoulidou, N; Schneps, J; Schreiner, P; Shanahan, P; Smart, W; Sousa, A; Speakman, B; Stamoulis, P; Strait, M; Tagg, N; Talaga, R L; Tavera, M A; Thomas, J; Thompson, J; Thomson, M A; Thron, J L; Tinti, G; Tzanakos, G; Urheim, J; Vahle, P; Viren, B; Watabe, M; Weber, A; Webb, R C; Wehmann, A; West, N; White, C; Wojcicki, S G; Yang, T; Zois, M; Zhang, K; Zwaska, R

    2008-01-01

    A search for a sidereal modulation in the MINOS near detector neutrino data was performed. If present, this signature could be a consequence of Lorentz and CPT violation as predicted by a class of extensions to the Standard Model. No evidence for a sidereal signal in the data set was found, implying that there is no significant change in neutrino propagation that depends on the direction of the neutrino beam in a sun-centered inertial frame. Upper limits on the magnitudes of the Lorentz and CPT violating terms in these extensions to the Standard Model lie between 0.01-1% of the maximum expected, assuming a suppression of these signatures by factor of $10^{-17}$. \\

  4. Measurement of the 8B Solar Neutrino Flux with KamLAND

    CERN Document Server

    Abe, S; Gando, A; Gando, Y; Ichimura, K; Ikeda, H; Inoue, K; Kibe, Y; Kimura, W; Kishimoto, Y; Koga, M; Minekawa, Y; Mitsui, T; Morikawa, T; Nagai, N; Nakajima, K; Nakamura, K; Nakamura, M; Narita, K; Shimizu, I; Shimizu, Y; Shirai, J; Suekane, F; Suzuki, A; Takahashi, H; Takahashi, N; Takemoto, Y; Tamae, K; Watanabe, H; Xu, B D; Yabumoto, H; Yonezawa, E; Yoshida, H; Yoshida, S; Enomoto, S; Kozlov, A; Murayama, H; Grant, C; Keefer, G; McKee, D; Piepke, A; Banks, T I; Bloxham, T; Detwiler, J A; Freedman, S J; Fujikawa, B K; Han, K; Kadel, R; O'Donnell, T; Steiner, H M; Winslow, L A; Dwyer, D A; Mauger, C; McKeown, R D; Zhang, C; Berger, B E; Lane, C E; Maricic, J; Miletic, T; Batygov, M; Learned, J G; Matsuno, S; Pakvasa, S; Sakai, M; Horton-Smith, G A; Tang, A; Downum, K E; Gratta, G; Tolich, K; Efremenko, Y; Kamyshkov, Y; Perevozchikov, O; Karwowski, H J; Markoff, D M; Tornow, W; Heeger, K M; Piquemal, F; Ricol, J -S; Decowski, M P

    2011-01-01

    We report a measurement of the neutrino-electron elastic scattering rate from 8B solar neutrinos based on a 123 kton-day exposure of KamLAND. The background-subtracted electron recoil rate, above a 5.5 MeV analysis threshold is 1.49+/-0.14(stat)+/-0.17(syst) events per kton-day. Interpreted as due to a pure electron flavor flux with a 8B neutrino spectrum, this corresponds to a spectrum integrated flux of 2.77+/-0.26(stat)+/-0.32(syst) x 10^6 cm^-2s^-1. The analysis threshold is driven by 208Tl present in the liquid scintillator, and the main source of systematic uncertainty is due to background from cosmogenic 11Be. The measured rate is consistent with existing measurements and with Standard Solar Model predictions which include matter enhanced neutrino oscillation.

  5. Measurement of the 8B Solar Neutrino Flux with KamLAND

    Energy Technology Data Exchange (ETDEWEB)

    Abe, S.; Furuno, K.; Gando, A.; Gando, Y.; Ichimura, K.; Ikeda, H.; Inoue, K.; Kibe, Y.; Kimura, W.; Kishimoto, Y.; Koga, M.; Minekawa, Y.; Mitsui, T.; Morikawa, T.; Nagai, N.; Nakajima, K.; Nakamura, K.; Nakamura, M.; Narita, K.; Shimizu, I.; Shimizu, Y.; Shirai, J.; Suekane, F.; Suzuki, A.; Takahashi, H.; Takahashi, N.; Takemoto, Y.; Tamae, K.; Watanabe, H.; Xu, B.D.; Yabumoto, H.; Yonezawa, E.; Yoshida, H.; Yoshida, S.; Enomoto, S.; Kozlov, A.; Murayama, H.; Grant, C.; Keefer, G.; McKee, D.; Piepke, A.; Banks, T.I.; Bloxham, T.; Detwiler, J.A.; Freedman, S.J.; Fujikawa, B.K.; Han, K.; Kadel, R.; O' Donnell, T.; Steiner, H.M.; Winslow, L.A.; Dwyer, D.A.; Mauger, C.; McKeown, R.D.; Zhang, C.; Berger, B.E.; Lane, C.E.; Maricic, J.; Miletic, T.; Batygov, M.; Learned, J.G.; Matsuno, S.; Pakvasa, S.; Sakai, M.; Horton-Smith, G.A.; Tang, A.; Downum, K.E.; Gratta, G.; Tolich, K.; Efremenko, Y.; Kamyshkov, Y.; Perevozchikov, O.; Karwowski, H.J.; Markoff, D.M.; Tornow, W.; Heeger, K.M.; Piquemal, F.; Ricol, J.-S.; Decowski, M.P.

    2011-06-04

    We report a measurement of the neutrino-electron elastic scattering rate from {sup 8}B solar neutrinos based on a 123 kton-day exposure of KamLAND. The background-subtracted electron recoil rate, above a 5.5-MeV analysis threshold is 1.49 {+-} 0.14(stat) {+-} 0.17(syst) events per kton-day. Interpreted as due to a pure electron flavor flux with a {sup 8}B neutrino spectrum, this corresponds to a spectrum integrated flux of 2.77 {+-} 0.26(stat) {+-} 0.32(syst) x 10{sup 6} cm{sup -2}s{sup -1}. The analysis threshold is driven by {sup 208}Tl present in the liquid scintillator, and the main source of systematic uncertainty is due to background from cosmogenic {sup 11}Be. The measured rate is consistent with existing measurements and with standard solar model predictions which include matter-enhanced neutrino oscillation.

  6. A study of extraterrestrial antineutrino sources with the KamLAND detector

    Energy Technology Data Exchange (ETDEWEB)

    The KamLAND Collaboration; Gando, A.; Gando, Y.; Ichimura, K.; Ikeda, H.; Inoue, K.; Kibe, Y.; Kishimoto, Y.; Koga, M.; Minekawa, Y.; Mitsui, T.; Morikawa, T.; Nagai, N.; Nakajima, K.; Nakamura, K.; Narita, K.; Shimizu, I.; Shimizu, Y.; Shirai, J.; Suekane, F.; Suzuki, A.; Takahashi, H.; Takahashi, N.; Takemoto, Y.; Tamae, K.; Watanabe, H.; Xu, B. D.; Yabumoto, H.; Yoshida, H.; Yoshida, S.; Enomoto, S.; Kozlov, A.; Murayama, H.; Grant, C.; Keefer, G.; Piepke, A.; Banks, T. I.; Bloxham, T.; Detwiler, J. A.; Freedman, S. J.; Fujikawa, B. K.; Han, K.; Kadel, R.; O' Donnell, T.; Steiner, H. M.; Dwyer, D. A.; McKeown, R. D.; Zhang, C.; Berger, B. E.; Lane, C. E.; Maricic, J.; Miletic, T.; Batygov, M.; Learned, J. G.; Matsuno, S.; Sakai, M.; Horton-Smith, G. A.; Downum, K. E.; Gratta, G.; Efremenko, Y.; Kamyshkov, Y.; Perevozchikov, O.; Karwowski, H. J.; Markoff, D. M.; Tornow, W.; Heeger, K. M.; Decowski, M. P.

    2011-05-18

    We present the results of a search for extraterrestrial electron antineutrinos ({bar {nu}}{sub e}'s) in the energy range 8.3 MeV < E{sub {bar {nu}}}{sub e} < 30.8 MeV using the KamLAND detector. In an exposure of 4.53 kton-year, we identify 25 candidate events. All of the candidate events can be attributed to background, most importantly neutral current atmospheric neutrino interactions, setting an upper limit on the probability of {sup 8}B solar {nu}{sub e}'s converting into {bar {nu}}{sub e}'s at 5.3 x 10{sup -5} (90% C.L.). The present data also allows us to set more stringent limits on the diffuse supernova neutrino flux and on the annihilation rates for light dark matter particles.

  7. A compact ultra-clean system for deploying radioactive sources inside the KamLAND detector

    Energy Technology Data Exchange (ETDEWEB)

    Banks, T.I., E-mail: tbanks@berkeley.edu [Physics Department, University of California, Berkeley, CA 94720 (United States); Lawrence Berkeley National Laboratory, Berkeley, CA 94720 (United States); Freedman, S.J. [Physics Department, University of California, Berkeley, CA 94720 (United States); Lawrence Berkeley National Laboratory, Berkeley, CA 94720 (United States); Kavli Institute for the Physics and Mathematics of the Universe (WPI), University of Tokyo, Kashiwa, Chiba 277-8583 (Japan); Wallig, J.; Ybarrolaza, N. [Lawrence Berkeley National Laboratory, Berkeley, CA 94720 (United States); Gando, A.; Gando, Y.; Ikeda, H. [Research Center for Neutrino Science, Tohoku University, Sendai 980-8578 (Japan); Inoue, K. [Research Center for Neutrino Science, Tohoku University, Sendai 980-8578 (Japan); Kavli Institute for the Physics and Mathematics of the Universe (WPI), University of Tokyo, Kashiwa, Chiba 277-8583 (Japan); Kishimoto, Y. [Kavli Institute for the Physics and Mathematics of the Universe (WPI), University of Tokyo, Kashiwa, Chiba 277-8583 (Japan); Research Center for Neutrino Science, Tohoku University, Sendai 980-8578 (Japan); Koga, M. [Research Center for Neutrino Science, Tohoku University, Sendai 980-8578 (Japan); Kavli Institute for the Physics and Mathematics of the Universe (WPI), University of Tokyo, Kashiwa, Chiba 277-8583 (Japan); Mitsui, T. [Research Center for Neutrino Science, Tohoku University, Sendai 980-8578 (Japan); Nakamura, K. [Research Center for Neutrino Science, Tohoku University, Sendai 980-8578 (Japan); Kavli Institute for the Physics and Mathematics of the Universe (WPI), University of Tokyo, Kashiwa, Chiba 277-8583 (Japan); Shimizu, I.; Shirai, J.; Suzuki, A.; Takemoto, Y.; Tamae, K.; Ueshima, K.; Watanabe, H.; Xu, B.D. [Research Center for Neutrino Science, Tohoku University, Sendai 980-8578 (Japan); and others

    2015-01-01

    We describe a compact, ultra-clean device used to deploy radioactive sources along the vertical axis of the KamLAND liquid-scintillator neutrino detector for purposes of calibration. The device worked by paying out and reeling in precise lengths of a hanging, small-gauge wire rope (cable); an assortment of interchangeable radioactive sources could be attached to a weight at the end of the cable. All components exposed to the radiopure liquid scintillator were made of chemically compatible UHV-cleaned materials, primarily stainless steel, in order to avoid contaminating or degrading the scintillator. To prevent radon intrusion, the apparatus was enclosed in a hermetically sealed housing inside a glove box, and both volumes were regularly flushed with purified nitrogen gas. An infrared camera attached to the side of the housing permitted real-time visual monitoring of the cable's motion, and the system was controlled via a graphical user interface.

  8. A compact ultra-clean system for deploying radioactive sources inside the KamLAND detector

    CERN Document Server

    Banks, T I; Wallig, J; Ybarrolaza, N; Gando, A; Gando, Y; Ikeda, H; Inoue, K; Kishimoto, Y; Koga, M; Mitsui, T; Nakamura, K; Shimizu, I; Shirai, J; Suzuki, A; Takemoto, Y; Tamae, K; Ueshima, K; Watanabe, H; Xu, B D; Yoshida, H; Yoshida, S; Kozlov, A; Grant, C; Keefer, G; Piepke, A; Bloxham, T; Fujikawa, B K; Han, K; Ichimura, K; Murayama, H; O'Donnell, T; Steiner, H M; Winslow, L A; Dwyer, D A; McKeown, R D; Zhang, C; Berger, B E; Lane, C E; Maricic, J; Miletic, T; Batygov, M; Learned, J G; Matsuno, S; Sakai, M; Horton-Smith, G A; Downum, K E; Gratta, G; Efremenko, Y; Perevozchikov, O; Karwowski, H J; Markoff, D M; Tornow, W; Heeger, K M; Detwiler, J A; Enomoto, S; Decowski, M P

    2014-01-01

    We describe a compact, ultra-clean device used to deploy radioactive sources along the vertical axis of the KamLAND liquid-scintillator neutrino detector for purposes of calibration. The device worked by paying out and reeling in precise lengths of a hanging, small-gauge wire rope (cable); an assortment of interchangeable radioactive sources could be attached to a weight at the end of the cable. All components exposed to the radiopure liquid scintillator were made of chemically compatible UHV-cleaned materials, primarily stainless steel, in order to avoid contaminating or degrading the scintillator. To prevent radon intrusion, the apparatus was enclosed in a hermetically sealed housing inside a glove box, and both volumes were regularly flushed with purified nitrogen gas. An infrared camera attached to the side of the housing permitted real-time visual monitoring of the cable's motion, and the system was controlled via a graphical user interface.

  9. How much Uranium is in the Earth? Predictions for geo-neutrinos at KamLAND

    CERN Document Server

    Fiorentini, G; Mantovani, F; Vannucci, R; Fiorentini, Gianni; Lissia, Marcello; Mantovani, Fabio; Vannucci, Riccardo

    2005-01-01

    Geo-neutrino detection can determine the amount of long-lived radioactive elements within our planet, thus providing a direct test of the Bulk Silicate Earth (BSE) model and fixing the radiogenic contribution to the terrestrial heat. We present a prediction for the geo-neutrino signal at KamLAND as a function of the Uranium mass in the Earth. The prediction is based on global mass balance, supplemented by a detailed geochemical and geophysical study of the region near the detector. The prediction is weakly dependent on mantle modeling. If BSE is correct, Uranium geo-neutrinos will produce between 25 and 35 events per year and 10^32 protons at Kamioka.

  10. Coherent population trapping (CPT) versus Electromagnetically induced transparency (EIT)

    CERN Document Server

    Khan, Sumanta; Chanu, Sapam Ranjita; Bharti, Vineet; Natarajan, Vasant

    2015-01-01

    We discuss the differences between two well-studied and related phenomena---coherent population trapping (CPT) and electromagnetically induced transparency (EIT). We show experimentally that one does not observe EIT in a Rb vapor cell filled with buffer gas, a kind of cell that is used commonly in CPT experiments because it results in significant linewidth reduction of the resonance.

  11. Irreducible representations of the CPT groups in QED

    CERN Document Server

    Perez, Brenda Carballo

    2009-01-01

    We construct the inequivalent irreducible representations (IIR's) of the CPT groups of the Dirac field operator \\hat{\\psi} and the electromagnetic quantum potential \\hat{A}_\\mu. The results are valid both for free and interacting (QED) fields. Also, and for the sake of completeness, we construct the IIR's of the CPT group of the Dirac equation.

  12. Covariant Quantization of CPT-violating Photons

    CERN Document Server

    Colladay, D; Noordmans, J P; Potting, R

    2016-01-01

    We perform the covariant canonical quantization of the CPT- and Lorentz-symmetry-violating photon sector of the minimal Standard-Model Extension, which contains a general (timelike, lightlike, or spacelike) fixed background tensor $k_{AF}^\\mu$. Well-known stability issues, arising from complex-valued energy states, are solved by introducing a small photon mass, orders of magnitude below current experimental bounds. We explicitly construct a covariant basis of polarization vectors, in which the photon field can be expanded. We proceed to derive the Feynman propagator and show that the theory is microcausal. Despite the occurrence of negative energies and vacuum-Cherenkov radiation, we do not find any runaway stability issues, because the energy remains bounded from below. An important observation is that the ordering of the roots of the dispersion relations is the same in any observer frame, which allows for a frame-independent condition that selects the correct branch of the dispersion relation. This turns ou...

  13. CPT Violation what and where to look for

    CERN Document Server

    Mavromatos, Nikolaos E

    2005-01-01

    In this review I classify the possible ways of CPT violation, and I describe briefly their phenomenology, in both terrestrial and astrophysical experiments, including antimatter factories, neutral mesons and neutrinos, and discuss the various sensitivities. I also pay attention to disentangling genuine quantum-gravity induced CPT violation from `fake' violation due to ordinary matter effects. A particularly interesting situation arises when the breaking of CPT invariance is through unitarity violations, in the sense of the matter theory being viewed as an effective field theory, entangled with decoherening quantum gravity ``environments''. In such a case the quantum mechanical CPT operator is ill defined due to another mathematical theorem, and one has novel effects associated with CPT Violating modifications of Einstein-Podolsky-Rosen type correlations of entangled meson states in B and phi meson factories.

  14. Laboratory Studies on the Removal of Radon-Born Lead from KamLAND's Organic Liquid Scintillator

    CERN Document Server

    Keefer, G; Piepke, A; Ebihara, T; Ikeda, H; Kishimoto, Y; Kibe, Y; Koseki, Y; Ogawa, M; Shirai, J; Takeuchi, S; Mauger, C; Zhang, C; Schweitzer, G; Berger, B E; Dazeley, S; Decowski, M P; Detwiler, J A; Djurcic, Z; Dwyer, D A; Efremenko, Y; Enomoto, S; Freedman, S J; Fujikawa, B K; Furuno, K; Gando, A; Gando, Y; Gratta, G; Hatakeyama, S; Heeger, K M; Hsu, L; Ichimura, K; Inoue, K; Iwamoto, T; Kamyshkov, Y; Karwowski, H J; Koga, M; Kozlov, A; Lane, C E; Learned, J G; Maricic, J; Marko, D M; Matsuno, S; McKee, D; McKeown, R D; Miletic, T; Mitsui, T; Motoki, M; Nakajima, K; Nakamura, K; O'Donnell, T; Ogawa, H; Piquemal, F; Ricol, J -S; Shimizu, I; Suekane, F; Suzuki, A; Svoboda, R; Tajima, O; Takemoto, Y; Tamae, K; Tolich, K; Tornow, W; Watanabe, Hideki; Watanabe, Hiroko; Winslow, L A; Yoshida, S

    2013-01-01

    The removal of radioactivity from liquid scintillator has been studied in preparation of a low background phase of KamLAND. This paper describes the methods and techniques developed to measure and efficiently extract radon decay products from liquid scintillator. We report the radio-isotope reduction factors obtained when applying various extraction methods. During this study, distillation was identified as the most efficient method for removing radon daughters from liquid scintillator.

  15. Search for electron antineutrinos associated with gravitational wave events GW150914 and GW151226 using KamLAND

    CERN Document Server

    Gando, A; Hachiya, T; Hayashi, A; Hayashida, S; Ikeda, H; Inoue, K; Ishidoshiro, K; Karino, Y; Koga, M; Matsuda, S; Mitsui, T; Nakamura, K; Obara, S; Oura, T; Ozaki, H; Shimizu, I; Shirahata, Y; Shirai, J; Suzuki, A; Takai, T; Tamae, K; Teraoka, Y; Ueshima, K; Watanabe, H; Kozolov, A; Takemoto, Y; Yoshida, S; Fushimi, K; Piepke, A; Banks, T I; Berger, B E; Fujikawa, B K; O'Donnell, T; Learned, J G; Maricic, J; Sakai, M; Winslow, L A; Krupczak, E; Ouellet, J; Efremenko, Y; Karwowski, H J; Markoff, D M; Tornow, W; Detwiler, J A; Enomoto, S; Decowski, M P

    2016-01-01

    We present a search for low energy antineutrino events coincident with the gravitational wave events GW150914 and GW151226, and the candidate event LVT151012 using KamLAND, a kiloton-scale antineutrino detector. We find no inverse beta-decay neutrino events within $\\pm 500$ seconds of either gravitational wave signal. This non-detection is used to constrain the electron antineutrino fluence and the luminosity of the astrophysical sources.

  16. Standard model with Lorentz and CPT violations in Finsler spacetime

    CERN Document Server

    Chang, Zhe

    2012-01-01

    Standard model with intrinsic Lorentz and CPT violations is proposed in a Finsler geometric framework. We present explicitly Lorentz and CPT--breaking Lagrangians of the matter fields and the gauge fields in locally Minkowski spacetime. The Lorentz invariance violation is found to be originated from the spacetime background deviating from the Minkowski one. Similarly, the CPT violation is determined by the behaviors of the locally Minkowski metric under the parity and time reversal operations. To help understanding phenomenologies, we compare the Finslerian model with the standard--model extension (SME) term by term at a first order approximation.

  17. Assumed PDF modeling in rocket combustor simulations

    Science.gov (United States)

    Lempke, M.; Gerlinger, P.; Aigner, M.

    2013-03-01

    In order to account for the interaction between turbulence and chemistry, a multivariate assumed PDF (Probability Density Function) approach is used to simulate a model rocket combustor with finite-rate chemistry. The reported test case is the PennState preburner combustor with a single shear coaxial injector. Experimental data for the wall heat flux is available for this configuration. Unsteady RANS (Reynolds-averaged Navier-Stokes) simulation results with and without the assumed PDF approach are analyzed and compared with the experimental data. Both calculations show a good agreement with the experimental wall heat flux data. Significant changes due to the utilization of the assumed PDF approach can be observed in the radicals, e. g., the OH mass fraction distribution, while the effect on the wall heat flux is insignificant.

  18. Testing CPT invariance with correlated neutral B decays

    CERN Document Server

    Balaji, K R S; Paschos, E A; Horn, Wilfried

    2003-01-01

    We study breakdown of $CPT$ symmetry which can occur in the decay process $B \\bar B \\to l^\\pm X^\\mp f$ with $f$ being a CP eigenstate. In this process, the standard model expectations for time ordered semi-leptonic and hadronic events, i.e. which of the two decays takes place first, can be altered in the case that there is a violation of the $CPT$ symmetry. To illustrate this possibility, we identify and study several time integrated observables. We find that an experiment with $10^{9}$ $B\\bar B$ pairs, has the capability for improving the bound on $CPT$ violating parameter or perhaps observe $CPT$ violation.

  19. CPT/Lorentz Invariance Violation and Quantum Field Theory

    CERN Document Server

    Arias, P; Gamboa-Rios, J; López-Sarrion, J; Méndez, F; Arias, Paola; Das, Ashok; Gamboa, Jorge; Lopez-Sarrion, Justo; Mendez, Fernando

    2006-01-01

    Analogies between the noncommutative harmonic oscillator and noncommutative fields are analyzed. Following this analogy we construct examples of quantum fields theories with explicit CPT and Lorentz symmetry breaking. Some applications to baryogenesis and neutrino oscillation are also discussed

  20. DEVELOPMENT OF A WIRELINE CPT SYSTEM FOR MULTIPLE TOOL USAGE

    Energy Technology Data Exchange (ETDEWEB)

    Stephen P. Farrington; Martin L. Gildea; J. Christopher Bianchi

    1999-08-01

    The first phase of development of a wireline cone penetrometer system for multiple tool usage was completed under DOE award number DE-AR26-98FT40366. Cone penetrometer technology (CPT) has received widespread interest and is becoming more commonplace as a tool for environmental site characterization activities at several Department of Energy (DOE) facilities. Although CPT already offers many benefits for site characterization, the wireline system can improve CPT technology by offering greater utility and increased cost savings. Currently the use of multiple CPT tools during a site characterization (i.e. piezometric cone, chemical sensors, core sampler, grouting tool) must be accomplished by withdrawing the entire penetrometer rod string to change tools. This results in multiple penetrations being required to collect the data and samples that may be required during characterization of a site, and to subsequently seal the resulting holes with grout. The wireline CPT system allows multiple CPT tools to be interchanged during a single penetration, without withdrawing the CPT rod string from the ground. The goal of the project is to develop and demonstrate a system by which various tools can be placed at the tip of the rod string depending on the type of information or sample desired. Under the base contract, an interchangeable piezocone and grouting tool was designed, fabricated, and evaluated. The results of the evaluation indicate that success criteria for the base contract were achieved. In addition, the wireline piezocone tool was validated against ASTM standard cones, the depth capability of the system was found to compare favorably with that of conventional CPT, and the reliability and survivability of the system were demonstrated.

  1. The Disquietude of Duty Assuming Kant

    Directory of Open Access Journals (Sweden)

    Max Maureira Pacheco

    2014-11-01

    Full Text Available For Kant, the moral duty is determined universally, that is, on account of its form, in the moral norm. However the moral norm is opposed to particularity, determined by what is not the norm itself, hence being the origin of singularity. The singularized norm is opposed, from experience, by its negation in individual cases. To assume Kant demands the reconciliation of the singular, manifested incases, with the universal. This article deals with this question, demonstrating, above all, the practical difficulties linked to the moral experience in its totality.

  2. CPT invariance and the spin-statistics connection

    CERN Document Server

    Bain, Jonathan

    2016-01-01

    This book seeks to answer the question "What explains CPT invariance and the spin-statistics connection?" These properties play foundational roles in relativistic quantum field theories (RQFTs), are supported by high-precision experiments, and figure into explanations of a wide range of phenomena, from antimatter, to the periodic table of the elements, to superconductors and superfluids. They can be derived in RQFTs by means of the famous CPT and Spin-Statistics theorems; but, the author argues, these theorems cannot be said to explain these properties, at least under standard philosophical accounts of scientific explanation. This is because there are multiple, in some cases incompatible, ways of deriving these theorems, and, secondly, because the theorems fail for the types of theories that underwrite the empirical evidence: non-relativistic quantum theories, and realistic interacting RQFTs. The goal of this book is to work towards an understanding of CPT invariance and the spin-statistics connection by firs...

  3. Camptothecin analog (CPT-11)-sensitive human pancreatic tumor cell line QGP-1N shows resistance to SN-38, an active metabolite of CPT-11.

    Science.gov (United States)

    Takeda, S; Shimazoe, T; Kuga, H; Sato, K; Kono, A

    1992-10-15

    In the course of our study to determine the cross-sensitivity between CPT-11 and its active metabolite, SN-38, we found a SN-38-resistant human pancreatic tumor cell line, QGP-1N, which shows sensitivity to CPT-11. The IC50 of SN-38 was 152 times greater for QGP-1N than for SUIT-2, also a human pancreatic tumor cell line, whose IC50 of CPT-11 was similar to that for QGP-1N. The uptakes of CPT-11 and SN-38 and the intracellular conversion of CPT-11 to SN-38 could not explain the difference in sensitivity. DNA synthesis of QGP-1N cells was inhibited by CPT-11 which did not affect that of SUIT-2, while SN-38 inhibited the DNA synthesis of SUIT-2 at lower concentrations than that of QGP-1N. The inhibition test of topoisomerase I catalytic activity by CPT-11 or SN-38 revealed no difference in the biochemical properties of the topoisomerase I enzymes to the compounds between these two cell lines. These results indicate that CPT-11 should have its own inhibitory effect on DNA synthesis through a yet unknown mechanism in QGP-1N cells, although SN-38 plays an essential role in the antitumor activity of CPT-11 in SUIT-2 cells. In some cases, the antitumor effect of CPT-11 might be consequent not only on SN-38 but also on CPT-11 itself.

  4. Lorentz and CPT violation in the Standard-Model Extension

    CERN Document Server

    Lehnert, Ralf

    2016-01-01

    Lorentz and CPT invariance are among the symmetries that can be investigated with ultrahigh precision in subatomic physics. Being spacetime symmetries, Lorentz and CPT invariance can be violated by minuscule amounts in many theoretical approaches to underlying physics that involve novel spacetime concepts, such as quantized versions of gravity. Regardless of the underlying mechanism, the low-energy effects of such violations are expected to be governed by effective field theory. This talk provides a survey of this idea and includes an overview of experimental efforts in the field.

  5. Search for CPT-odd decays of positronium

    Energy Technology Data Exchange (ETDEWEB)

    Vetter, Paul A.; Freedman, Stuart J.

    2003-07-11

    We have limited a CPT-violating correlation in annihilationsof polarized ortho-positronium. We searched for an asymmetry in thetriple correlations dot k1 cross k2, where k1 and k2 are the two largestphoton momenta, and s is the spin of the positronium. Using theGammasphere array of Compton-suppressed high-purity germanium detectors,we detected 2.65e7 events of ortho-Ps annihila tion. The amplitude of aCPT-violating asymmetry in the data set is found to be 0.0026 plus orminus 0.0031, a factor of 6 smaller than previousexperiments.

  6. The Origin and Diversity of Cpt1 Genes in Vertebrate Species.

    Directory of Open Access Journals (Sweden)

    Mónica Lopes-Marques

    Full Text Available The Carnitine palmitoyltransferase I (Cpt1 gene family plays a crucial role in energy homeostasis since it is required for the occurrence of fatty acid β-oxidation in the mitochondria. The exact gene repertoire in different vertebrate lineages is variable. Presently, four genes are documented: Cpt1a, also known as Cpt1a1, Cpt1a2; Cpt1b and Cpt1c. The later is considered a mammalian innovation resulting from a gene duplication event in the ancestor of mammals, after the divergence of sauropsids. In contrast, Cpt1a2 has been found exclusively in teleosts. Here, we reassess the overall evolutionary relationships of Cpt1 genes using a combination of approaches, including the survey of the gene repertoire in basal gnathostome lineages. Through molecular phylogenetics and synteny studies, we find that Cpt1c is most likely a rapidly evolving orthologue of Cpt1a2. Thus, Cpt1c is present in other lineages such as cartilaginous fish, reptiles, amphibians and the coelacanth. We show that genome duplications (2R and variable rates of sequence evolution contribute to the history of Cpt1 genes in vertebrates. Finally, we propose that loss of Cpt1b is the likely cause for the unusual energy metabolism of elasmobranch.

  7. Prospects for Lorentz and CPT tests with hydrogen and antihydrogen

    CERN Document Server

    Becker, Tobias Frederic

    2017-01-01

    As a summer student for 13 weeks in the ASACUSA-CUSP collaboration, under the supervision of Chloé Malbrunot, my project consisted in a first part on the theoretical treatment of Lorentz and CPT violation in hydrogen & antihydrogen in the framework of the Standard Model Extension SME and in second part on experimental measurements on a hydrogen beam.

  8. Lorentz- and CPT-symmetry studies in subatomic physics

    Energy Technology Data Exchange (ETDEWEB)

    Lehnert, Ralf, E-mail: ralehner@indiana.edu [Leibniz Universität Hannover (Germany)

    2016-12-15

    Subatomic systems provide an exquisite test bench for spacetime symmetries. This work motivates such measurements, reviews the effective field theory test framework for the description of Lorentz and CPT violation, and employs this framework to study the phenomenology of spacetime-symmetry breaking in various subatomic systems.

  9. Testing Lorentz and CPT Symmetries in Penning Traps

    CERN Document Server

    Ding, Yunhua

    2016-01-01

    A modified Dirac equation with general Lorentz- and CPT-violating operators in the electromagnetic field is studied. Constraints on and possible sensitivities to Lorentz-violating coefficients in the nonminimal sector up to mass-dimension six can be obtained by analyzing Penning-trap results involving anomaly frequencies.

  10. Gravity couplings in the standard model: CPT nonconservation

    Energy Technology Data Exchange (ETDEWEB)

    Chang, Lay Nam [Physics Department, Virginia Tech, Blacksburg, Virginia 24061-0435 (United States)] Soo, Chopin [Center for Theoretical Science, National Tsinghua University, Hsinchu, Republic of (China)

    1998-10-01

    Chiral asymmetric couplings are a basic feature of the standard model. We show that gravity couplings which manifestly preserve this feature are necessarily complex, and that as a result parity nonconservation can take place in the gravity sector. Implications for breakdown of CPT symmetry are also discussed. {copyright} {ital 1998 American Institute of Physics.}

  11. Probing CPT in transitions with entangled neutral kaons

    CERN Document Server

    Bernabeu, J; Villanueva-Perez, P

    2015-01-01

    In this paper we present a novel CPT symmetry test in the neutral kaon system based, for the first time, on the direct comparison of the probabilities of a transition and its CPT reverse. The required interchange of "in" $\\leftrightarrow$ "out" states for a given process is obtained exploiting the Einstein-Podolsky-Rosen correlations of neutral kaon pairs produced at a $\\phi$-factory. The observable quantities have been constructed by selecting the two semileptonic decays for flavour tag, the $\\pi\\pi$ and $3\\pi^0$ decays for CP tag and the time orderings of the decay pairs. The interpretation in terms of the standard Weisskopf-Wigner approach to this system, directly connects CPT violation in these observables to the violating $\\Re\\delta$ parameter in the mass matrix of $K^0$-$\\bar{K^0}$, a genuine CPT violating effect independent of $\\Delta \\Gamma$ and not requiring the decay as an essential ingredient. Possible spurious effects induced by CP violation in the decay and/or a violation of the $\\Delta S= \\Delta...

  12. Neutron-antineutron transition as a test-bed for dynamical CPT violations

    Science.gov (United States)

    Addazi, Andrea

    2016-05-01

    We show a simple mechanism for a dynamical CPT violation in the neutron sector. In particular, we show a CPT-violating see-saw mechanism, generating a Majorana mass and a CPT-violating mass for the neutron. CPT-violating see-saw involves a sterile partner of the neutron, living in a hidden sector, in which CPT is spontaneously broken. In particular, neutrons (antineutrons) can communicate with the hidden sector through nonperturbative quantum gravity effects called exotic instantons. Exotic instantons dynamically break R-parity, generating one effective vertex between the neutron and its sterile partner. In this way, we show how a small CPT-violating mass term for the neutron is naturally generated. This model can be tested in the next generation of experiments in neutron-antineutron physics. This strongly motivates researches of CPT-violating effects in neutron-antineutron physics as a test-bed for dynamical CPT-violations in SM.

  13. CP violation and CPT invariance in B+- decays with final state interactions

    CERN Document Server

    Bediaga, I; Lourenço, O

    2013-01-01

    We show that final state interactions together with CPT invariance can play an important role in the recent observation of CP violation in three-body charmless B decays. A significant part of the observed CP asymmetry distribution in the Dalitz plot is located in a region where hadronic channels are strongly coupled. We assume that this CP violation distribution is basically due to the interference of two CP-conserving hadron-hadron amplitudes separated by a CP-noninvariant weak phase. We illustrate our discussion comparing the recent observation of CP violation in the B+-\\to K+-K+K- and B+-\\to K+-{\\pi}+{\\pi}- phase space, with a calculation based on {\\pi}{\\pi}\\to KK scattering.

  14. CPT symmetry and antimatter gravity in general relativity

    CERN Document Server

    Villata, M

    2011-01-01

    The gravitational behavior of antimatter is still unknown. While we may be confident that antimatter is self-attractive, the interaction between matter and antimatter might be either attractive or repulsive. We investigate this issue on theoretical grounds. Starting from the CPT invariance of physical laws, we transform matter into antimatter in the equations of both electrodynamics and gravitation. In the former case, the result is the well-known change of sign of the electric charge. In the latter, we find that the gravitational interaction between matter and antimatter is a mutual repulsion, i.e. antigravity appears as a prediction of general relativity when CPT is applied. This result supports cosmological models attempting to explain the Universe accelerated expansion in terms of a matter-antimatter repulsive interaction.

  15. CPT symmetry and antimatter gravity in general relativity

    Science.gov (United States)

    Villata, M.

    2011-04-01

    The gravitational behavior of antimatter is still unknown. While we may be confident that antimatter is self-attractive, the interaction between matter and antimatter might be either attractive or repulsive. We investigate this issue on theoretical grounds. Starting from the CPT invariance of physical laws, we transform matter into antimatter in the equations of both electrodynamics and gravitation. In the former case, the result is the well-known change of sign of the electric charge. In the latter, we find that the gravitational interaction between matter and antimatter is a mutual repulsion, i.e. antigravity appears as a prediction of general relativity when CPT is applied. This result supports cosmological models attempting to explain the Universe accelerated expansion in terms of a matter-antimatter repulsive interaction.

  16. Lorentz- and CPT-violating extension of the standard model

    CERN Document Server

    Kostelecky, V A

    1999-01-01

    The formulation and some experimental implications of a general Lorentz-violating extension of the standard model are reviewed. The theory incorporates both CPT-preserving and CPT-breaking terms. It is otherwise a conventional quantum field theory, obtained under the assumption that Lorentz symmetry is spontaneously broken in an underlying model. The theory contains the usual standard-model gauge structure, and it is power-counting renormalizable. Energy and momentum are conserved. Despite the violation of Lorentz symmetry, the theory exhibits covariance under Lorentz transformations of the observer inertial frame. A general Lorentz-violating extension of quantum electrodynamics can be extracted. The standard-model extension implies potentially observable effects in a wide variety of experiments, including among others measurements on neutral-meson oscillations, comparative studies in Penning traps, spectroscopy of hydrogen and antihydrogen, bounds on cosmological birefringence, measurements of muon propertie...

  17. CPT-odd Photon in Vacuum-Orthogonal Model

    CERN Document Server

    Albayrak, Soner

    2015-01-01

    Lorentz and CPT violation in the photon sector with the operators of arbitrary mass dimension has been proposed in the context of Standard-Model Extension. The CPT-odd subset of this enlarged model is investigated from a quantum-field theoretical point of view. The generic forms of dispersion relations, polarization vectors and the propagators are obtained for this special subset. Particularly, the general vacuum-orthogonal model is analyzed and it is demonstrated that the vacuum orthogonal model remains vacuum orthogonal at all orders. Although the model has birefringent solutions, they are shown to be spurious. Furthermore, the relevant polarization vectors are shown to be conventional. Leading order model is explicitly analyzed and it is demonstrated that there exists a nontrivial coefficient space satisfying above properties.

  18. Lorentz invariant CPT breaking in the Dirac equation

    CERN Document Server

    Fujikawa, Kazuo

    2016-01-01

    If one modifies the Dirac equation in momentum space to $[\\gamma^{\\mu}p_{\\mu}-m-\\Delta m(\\theta(p_{0})-\\theta(-p_{0})) \\theta(p_{\\mu}^{2})]\\psi(p)=0$, the symmetry of positive and negative energy eigenvalues is lifted by $m\\pm \\Delta m$ for a small $\\Delta m$. The mass degeneracy of the particle and antiparticle is thus lifted in a Lorentz invariant manner since the combinations $\\theta(\\pm p_{0})\\theta(p_{\\mu}^{2})$ with step functions are manifestly Lorentz invariant. We explain an explicit construction of this CPT breaking term in coordinate space, which is Lorentz invariant but non-local at a distance scale of the Planck length. The application of this Lorentz invariant CPT breaking mechanism to the possible mass splitting of the neutrino and antineutrino in the Standard Model is briefly discussed.

  19. Skeletal Muscle-Specific CPT1 Deficiency Elevates Lipotoxic Intermediates but Preserves Insulin Sensitivity

    Directory of Open Access Journals (Sweden)

    Wanchun Shi

    2013-01-01

    Full Text Available Objective. By specific knockout of carnitine palmitoyl transferase 1b (CPT1b in skeletal muscles, we explored the effect of CPT1b deficiency on lipids and insulin sensitivity. Methods. Mice with specific knockout of CPT1b in skeletal muscles (CPT1b M−/− were used for the experiment group, with littermate C57BL/6 as controls (CPT1b. General and metabolic profiles were measured and compared between groups. mRNA expression and CPT1 activity were measured in skeletal muscle tissues and compared between groups. Mitochondrial fatty acid oxidation (FAO, triglycerides (TAGs, diglycerides (DAGs, and ceramides were examined in skeletal muscles in two groups. Phosphorylated AKT (pAkt and glucose transporter 4 (Glut4 were determined with real-time polymerase chain reaction (RT-PCR. Insulin tolerance test, glucose tolerance test, and pyruvate oxidation were performed in both groups. Results. CPT1b M−/− model was successfully established, with impaired muscle CPT1 activity. Compared with CPT1b mice, CPT1b M−/− mice had similar food intake but lower body weight or fat mass and higher lipids but similar glucose or insulin levels. Their mitochondrial FAO of skeletal muscles was impaired. There were lipids accumulations (TAGs, DAGs, and ceramides in skeletal muscle. However, pAkt and Glut4, insulin sensitivity, glucose tolerance, and pyruvate oxidation were preserved. Conclusion. Skeletal muscle-specific CPT1 deficiency elevates lipotoxic intermediates but preserves insulin sensitivity.

  20. Cherenkov Radiation with Massive, CPT-violating Photons

    CERN Document Server

    Colladay, Don; Potting, Robertus

    2016-01-01

    The source of CPT-violation in the photon sector of the Standard Model Extension arises from a Chern-Simons-like contribution that involves a coupling to a fixed background vector field $k_{AF}^\\mu$. These Lorentz- and CPT-violating photons have well-known theoretical issues that arise from missing states at low momenta when $k_{AF}^\\mu$ is timelike. In order to make the theory consistent, a tiny mass for the photon can be introduced, well below current experimental bounds. The implementation of canonical quantization can then be implemented as in the CPT-preserving case by using the St\\"uckelberg mechanism. We explicitly construct a covariant basis of properly-normalized polarization vectors at fixed three-momentum satisfying the momentum space field equations, in terms of which the vector field can be expanded. As an application of the theory, we calculate the Cherenkov radiation rate for the case of purely timelike $k_{AF}^\\mu$, and find a radiation rate at high energies that has a contribution that does n...

  1. Checking T and CPT violation with sterile neutrino

    Directory of Open Access Journals (Sweden)

    Yogita Pant

    2016-08-01

    Full Text Available Post LSND results, sterile neutrinos have drawn attention and motivated the high energy physics, astronomy and cosmology to probe physics beyond the standard model considering minimal 3+1 (3 active and 1 sterile to 3+N neutrino schemes. The analytical equations for neutrino conversion probabilities are developed in this work for 3+1 neutrino scheme. Here, we have tried to explore the possible signals of T and CPT violations with four flavor neutrino scheme at neutrino factory. Values of sterile parameters considered in this analysis are taken from two different types of neutrino experiments viz. long baseline experiments and reactor+atmospheric experiments. In this work golden and discovery channels are selected for the investigation of T violation. While observing T violation we stipulate that neutrino factory working at 50 GeV energy has the potential to observe the signatures of T violation through discovery channel if sterile parameter values are equal to that taken from reactor+atmospheric experiments. The ability of neutrino factory for constraining CPT violation is enhanced with increase in energy for normal neutrino mass hierarchy (NH. Neutrino factory with the exposure time of 500 kt-yr will be able to capture CPT violation with δc31≥3.6×10−23 GeV at 3σ level for NH and for IH with δc31≥4×10−23 GeV at 3σ level.

  2. White paper: CeLAND - Investigation of the reactor antineutrino anomaly with an intense 144Ce-144Pr antineutrino source in KamLAND

    CERN Document Server

    Gando, A; Ichimura, K; Ikeda, H; Inoue, K; Kibe, Y; Kishimoto, Y; Koga, M; Minekawa, Y; Mitsui, T; Morikawa, T; Nagai, N; Nakamura, K Nakajima K; Narita, K; Shimizu, I; Shimizu, Y; Shirai, J; Suekane, F; Suzuki, A; Takahashi, H; Takahashi, N; Takemoto, Y; Tamae, K; Watanabe, H; Xu, B D; Yabumoto, H; Yoshida, H; Yoshida, S; Berger, B E; Cribier, M; Decowski, P; Detwiler, J A; Durero, M; Dwyer, D; Efremenko, Y; Enomoto, S; Fischer, V; Fujikawa, B K; Gaffiot, J; Gelis, V M; Karwowski, H J; Kolomensky, Yu G; Kornoukhov, N; Lasserre, T; Learned, J G; Letourneau, A; Lhuillier, D; Maricic, J; Markoff, D M; Matsuno, S; Mention, G; Milincic, R; O'Donnell, T; Saldikov, I S; Scola, L; Tikhomirov, G V; Veyssiere, Ch; Vivier, M

    2013-01-01

    We propose to test for short baseline neutrino oscillations, implied by the recent reevaluation of the reactor antineutrino flux and by anomalous results from the gallium solar neutrino detectors. The test will consist of producing a 75 kCi 144Ce - 144Pr antineutrino source to be deployed in the Kamioka Liquid Scintillator Anti-Neutrino Detector (KamLAND). KamLAND's 13m diameter target volume provides a suitable environment to measure energy and position dependence of the detected neutrino flux. A characteristic oscillation pattern would be visible for a baseline of about 10 m or less, providing a very clean signal of neutrino disappearance into a yet-unknown, "sterile" state. Such a measurement will be free of any reactor-related uncertainties. After 1.5 years of data taking the Reactor Antineutrino Anomaly parameter space will be tested at > 95% C.L.

  3. Effect of atomic diffusion on the Raman-Ramsey CPT resonances

    CERN Document Server

    Kuchina, Elena; Novikova, Irina

    2015-01-01

    We experimentally investigated the characteristics of two-photon transmission resonances in Rb vapor cells with different amount of buffer gas under the conditions of steady-state coherent population trapping (CPT) and pulsed Raman-Ramsey (RR-) CPT interrogation scheme. We particularly focused on the influence of the Rb atoms diffusing in and out of the laser beam. We showed that this effect modifies the shape of both CPT and Raman-Ramsey resonances, as well as their projected performance for CPT clock applications. In particular we found that at moderate buffer gas pressures RR-CPT did not improved the projected atomic clock stability compare to the regular steady-state CPT resonance.

  4. Constraining CPT-odd nonminimal interactions in the Electroweak sector

    CERN Document Server

    Mouchrek-Santos, Victor E

    2016-01-01

    In this work, we propose two possibilities of CPT-odd and Lorentz-violating (LV) nonminimal couplings in the Electroweak sector. These terms are gauge-invariant and couple a fixed 4-vector to the physical fields of the theory. After determining the LV contributions to the electroweak currents, we reassess the evaluation of the decay rate for the vector mediators $W$ and $Z$. Using the experimental uncertainty in these decay rates, upper bounds of $1$ part in $10^{-15}$ (eV )$^{-1}$ and $10^{-14}$ (eV )$^{-1}$ are imposed on the magnitude of the proposed nonmimal interactions.

  5. Tests of CPT, Lorentz invariance and the WEP with antihydrogen

    Energy Technology Data Exchange (ETDEWEB)

    Holzscheiter, M.H.; ATHENA Collaboration

    1999-03-01

    Antihydrogen atoms, produced near rest, trapped in a magnetic well, and cooled to the lowest possible temperature (kinetic energy) could provide an extremely powerful tool for the search of violations of CPT and Lorentz invariance. Equally well, such a system could be used for searches of violations of the Weak Equivalence Principle (WEP) at high precision. The author describes his plans to form a significant number of cold, trapped antihydrogen atoms for comparative precision spectroscopy of hydrogen and antihydrogen and comment on possible first experiments.

  6. Atmospheric neutrinos as a probe of CPT violation

    Energy Technology Data Exchange (ETDEWEB)

    Datta, Anindya [INFN, Sezione di Roma, Dipartimento di Fisica, Universita La Sapienza, I-00185 Rome (Italy)]. E-mail: anindya.datta@roma1.infn.it; Gandhi, Raj [Harish-Chandra Research Institute, Chhatnag Road, Jhunsi, Allahabad 211 019 (India)]. E-mail: raj@mri.ernet.in; Mehta, Poonam [Department of Physics and Astrophysics, University of Delhi, Delhi 110 019 (India) and Harish-Chandra Research Institute, Chhatnag Road, Jhunsi, Allahabad 211 019 (India)]. E-mail: mpoonam@mri.ernet.in; Sankar, S. Uma [Department of Physics, IIT, Powai, Mumbai 400 076 (India)]. E-mail: uma@phy.iitb.ac.in

    2004-09-16

    We show that atmospheric neutrinos can provide a sensitive and robust probe of CPT violation (CPTV). We perform realistic event-rate calculations and study the variations of the ratio of total muon to antimuon survival rates with L/E and L (L= baseline length, E = neutrino energy) in a detector capable of identifying the muon charge. We demonstrate that measurements of these ratios when coupled with the significant L and E range which characterizes the atmospheric neutrino spectrum provides a method of both detecting the presence of such violations and putting bounds on them which compare very favorably with those possible from a future neutrino factory.

  7. Lorentz and CPT violation in the hydrogen spectrum

    CERN Document Server

    Adkins, Gregory S

    2013-01-01

    We have studied the effect of hypothetical violations of Lorentz and CPT symmetry by calculating the corrections to the energy levels of hydrogen induced by the Standard-Model Extension (SME). Hydrogen studies are interesting because the energy levels of hydrogen can be measured with great precision and the theory for hydrogen based on the Standard Model (SM) is well understood. We obtained corrections through order \\alpha^2 times the SME parameters for all levels of hydrogen and applied them to determine the SME corrections to the transition frequency for the 2S-1S transition.

  8. The Carnitine Palmitoyl Transferase (CPT) System and Possible Relevance for Neuropsychiatric and Neurological Conditions.

    Science.gov (United States)

    Virmani, Ashraf; Pinto, Luigi; Bauermann, Otto; Zerelli, Saf; Diedenhofen, Andreas; Binienda, Zbigniew K; Ali, Syed F; van der Leij, Feike R

    2015-10-01

    The carnitine palmitoyl transferase (CPT) system is a multiprotein complex with catalytic activity localized within a core represented by CPT1 and CPT2 in the outer and inner membrane of the mitochondria, respectively. Two proteins, the acyl-CoA synthase and a translocase also form part of this system. This system is crucial for the mitochondrial beta-oxidation of long-chain fatty acids. CPT1 has two well-known isoforms, CPT1a and CPT1b. CPT1a is the hepatic isoform and CPT1b is typically muscular; both are normally utilized by the organism for metabolic processes throughout the body. There is a strong evidence for their involvement in various disease states, e.g., metabolic syndrome, cardiovascular diseases, and in diabetes mellitus type 2. Recently, a new, third isoform of CPT was described, CPT1c. This is a neuronal isoform and is prevalently localized in brain regions such as hypothalamus, amygdala, and hippocampus. These brain regions play an important role in control of food intake and neuropsychiatric and neurological diseases. CPT activity has been implicated in several neurological and social diseases mainly related to the alteration of insulin equilibrium in the brain. These pathologies include Parkinson's disease, Alzheimer's disease, and schizophrenia. Evolution of both Parkinson's disease and Alzheimer's disease is in some way linked to brain insulin and related metabolic dysfunctions with putative links also with the diabetes type 2. Studies show that in the CNS, CPT1c affects ceramide levels, endocannabionoids, and oxidative processes and may play an important role in various brain functions such as learning.

  9. CPT conservation and atmospheric neutrinos in the MINOS far detector

    Energy Technology Data Exchange (ETDEWEB)

    Becker, Bernard Raymond [Univ. of Minnesota, Minneapolis, MN (United States)

    2006-02-01

    The MINOS Far Detector is a 5400 ton iron calorimeter located at the Soudan state park in Soudan Minnesota. The MINOS far detector can observe atmospheric neutrinos and separate charge current νμ and $\\bar{v}$μ interactions by using a 1.4 T magnetic field to identify the charge of the produced muon. The CPT theorem requires that neutrinos and anti-neutrinos oscillate in the same way. In a fiducial exposure of 5.0 kilo-ton years a total of 41 candidate neutrino events are observed with an expectation of 53.1 ± 7.6(system.) ± 7.2(stat.) unoscillated events or 31.6 ± 4.7(system.) ± 5.6(stat.) events with Δm2 = 2.4 x 10-3 eV2, sin2(2θ) = 1.0 as oscillation parameters. These include 28 events which can have there charge identified with high confidence. These 28 events consist of 18 events consistent with being produced by νμ and 10 events being consistent with being produced by $\\bar{v}$μ. No evidence of CPT violation is observed.

  10. Suppressed $B \\to PV $ CP asymmetry: CPT constraint

    CERN Document Server

    Nogueira, J H Alvarenga; Frederico, T; Magalhães, P C; Rodriguez, J Molina

    2016-01-01

    Charge Parity asymmetry in charmless B meson decays is a key issue to be understood. Many theoretical calculations have been performed using short distance factorization approaches which, in general, do not take into account the CPT invariance constraint. For each channel with CP violation there is an equal amount of CP asymmetry in another channel or other channels, with an opposite sign. This happens if these channels are coupled through final state interactions (FSI). In the specific process $B\\to PV$, involving one pseudo-scalar and one vector particle in the final state, we argue that the CP asymmetry, inherent from a short distance mechanism, could be suppressed due to the CPT constraint. In this case, we propose a sensitive and practical experimental method to identify even a small CP asymmetry, which provides the values for $A_{CP}$ without the need for an amplitude analysis. This method, if applied directly to data, will enable to extract the CP asymmetry information in a model independent way and ch...

  11. The invariance of classical electromagnetism under Charge-conjugation, Parity and Time-reversal (CPT) transformations

    Science.gov (United States)

    Norbury, John W.

    1989-01-01

    The invariance of classical electromagnetism under charge-conjugation, parity, and time-reversal (CPT) is studied by considering the motion of a charged particle in electric and magnetic fields. Upon applying CPT transformations to various physical quantities and noting that the motion still behaves physically demonstrates invariance.

  12. Search for Lorentz and CPT violation effects in muon spin precession

    NARCIS (Netherlands)

    Bennett, G. W.; Bousquet, B.; Brown, H. N.; Bunce, G.; Carey, R. M.; Cushman, P.; Danby, G. T.; Debevec, P. T.; Deile, M.; Deng, H.; Deninger, W.; Dhawan, S. K.; Druzhinin, V. P.; Duong, L.; Efstathiadis, E.; Farley, F. J. M.; Fedotovich, G. V.; Giron, S.; Gray, F. E.; Grigoriev, D.; Grosse-Perdekamp, M.; Grossmann, A.; Hare, M. F.; Hertzog, D. W.; Huang, X.; Hughes, V. W.; Iwasaki, M.; Jungmann, K.; Kawall, D.; Kawamura, M.; Khazin, B. I.; Kindem, J.; Krienen, F.; Kronkvist, I.; Lam, A.; Larsen, R.; Lee, Y. Y.; Logashenko, I.; McNabb, R.; Meng, W.; Mi, J.; Miller, J. P.; Mizumachi, Y.; Morse, W. M.; Nikas, D.; Onderwater, C. J. G.; Orlov, Y.; Oezben, C. S.; Paley, J. M.; Peng, Q.; Polly, C. C.; Pretz, J.; Prigl, R.; Putlitz, G. zu; Qian, T.; Redin, S. I.; Rind, O.; Roberts, B. L.; Ryskulov, N.; Sedykh, S.; Semertzidis, Y. K.; Shagin, P.; Shatunov, Yu. M.; Sichtermann, E. P.; Solodov, E.; Sossong, M.; Steinmetz, A.; Sulak, L. R.; Timmermans, C.; Trofimov, A.; Urner, D.; von Walter, P.; Warburton, D.; Winn, D.; Yamamoto, A.; Zimmerman, D.; Bennet, G.W.; Ozben, C.

    2008-01-01

    The spin precession frequency of muons stored in the (g-2) storage ring has been analyzed for evidence of Lorentz and CPT violation. Two Lorentz and CPT violation signatures were searched for a nonzero Delta omega(a)(=omega(mu+)(a)-omega(mu-)(a)) and a sidereal variation of omega(mu+)(a). No signifi

  13. The Weyl Theory of Fundamental Interactions Is CPT violated?

    CERN Document Server

    Soo, C P; Soo, Chopin; Chang, Lay Nam

    1997-01-01

    We compare the conventional description of the interaction of matter with the four known forces in the standard model with an alternative Weyl description in which the chiral coupling is extended to include gravity. The two are indistinguishable at the low energy classical level of equations of motion, but there are subtle differences at the quantum level when nonvanishing torsion and the Adler-Bell-Jackiw anomaly is taken into account. The spin current and energy-momentum of the chiral theory then contain non-Hermitian terms which are not present in the conventional theory. In the chiral alternative, CPT invariance is not automatic because chirality supersedes Hermiticity but full Lorentz invariance holds. New fermion loop processes associated with the theory are discussed together with a perturbative regularization which explicitly maintains the chiral nature and local symmetries of the theory.

  14. Simultaneously improving the sensitivity and absolute accuracy of CPT magnetometer.

    Science.gov (United States)

    Liang, Shang-Qing; Yang, Guo-Qing; Xu, Yun-Fei; Lin, Qiang; Liu, Zhi-Heng; Chen, Zheng-Xiang

    2014-03-24

    A new method to improve the sensitivity and absolute accuracy simultaneously for coherent population trapping (CPT) magnetometer based on the differential detection method is presented. Two modulated optical beams with orthogonal circular polarizations are applied, in one of which two magnetic resonances are excited simultaneously by modulating a 3.4GHz microwave with Larmor frequency. When a microwave frequency shift is introduced, the difference in the power transmitted through the cell in each beam shows a low noise resonance. The sensitivity of 2pT/Hz @ 10Hz is achieved. Meanwhile, the absolute accuracy of ± 0.5nT within the magnetic field ranging from 20000nT to 100000nT is realized.

  15. Inducing Proactive Control Shifts in the AX-CPT.

    Science.gov (United States)

    Gonthier, Corentin; Macnamara, Brooke N; Chow, Michael; Conway, Andrew R A; Braver, Todd S

    2016-01-01

    The Dual Mechanisms of Control (DMC) account (Braver, 2012) proposes two distinct mechanisms of cognitive control, proactive and reactive. This account has been supported by a large number of studies using the AX-CPT paradigm that have demonstrated not only between-group differences, but also within-subjects variability in the use of the two control mechanisms. Yet there has been little investigation of task manipulations that can experimentally modulate the use of proactive control in healthy young adults; such manipulations could be useful to better understand the workings of cognitive control mechanisms. In the current study, a series of three experiments demonstrate how individuals can be systematically biased toward and away from the utilization of proactive control, via strategy training and no-go manipulations, respectively. These results provide increased support for the DMC framework, and provide a new basis from which to examine group-based differences and neural mechanisms underlying the two control modes.

  16. New medical psychotherapy CPT coding: the tail wagging the dog?

    Science.gov (United States)

    Clemens, Norman A

    2013-03-01

    The implications of the 2013 revised current procedural terminology (CPT) system for coding psychotherapy with medical evaluation and management (E&M) are discussed. The author expresses concern about a potential devaluing of psychotherapy because of the required order of reporting combined codes, with E&M the primary code. Procedural and documentation requirements for using the standard medical E&M codes challenge psychiatrists to be systematic and efficient in order not to interfere with time and attention essential to an effective psychotherapy process. Insensitive use of computers when working with patients can damage rapport and progress. The trend toward sharing personal health information in large systems calls for heightened discretion. Using the psychotherapy notes protected under the Health Insurance Portability and Accountability Act (HIPAA) for highly sensitive personal information is essential to preserve patient privacy.

  17. Discussion on Neutrino Oscillation and CPT/Lorentz Invariance Violation

    CERN Document Server

    Luo, Cui-Bai; Du, Yi-Lun; Wang, Yong-Long; Zong, Hong-Shi

    2016-01-01

    Depending on deformed canonical anticommutation relations, massless neutrino oscillation based on CPT /Lorentz invariance viol ation is discussed. It is found that the deformed canonical anti-commutation relations should satisfy the condition of new Moy al product and new non standard commutation relations. Furthermore, by comparing the neutrino experimental data and the above relations, we find that the orders of magnitude of noncommutative parameters or Lorentz invariant Violation parameters $\\mathi t{A}$ is not self-consistent. This means that the previous studies about Lorentz invariance violation in noncommutative field theory may not naturally explain massless neutrino oscillation. In other words, it should be impossible to explain neutrino os cillation by lorentz invariance violation. This conclusion is supported by the latest atmospheric neutrinos experimental resul ts from Super-Kamiokande Collaboration, which show that no evidence of Lorentz invariance violation on atmospheric neutrinos w as observe...

  18. Case Study of CPT-based Design Methods for Axial Capacity of Driven Piles in Sand

    DEFF Research Database (Denmark)

    Thomassen, Kristina; Ibsen, Lars Bo; Andersen, Lars Vabbersgaard

    2012-01-01

    Today the design of onshore axially loaded driven piles in cohesionless soil is commonly made on basis of CPT-based methods because field investigations have shown strong correlation between the local shaft friction and the CPT cone resistance. However, the recommended design method for axially....... Thus, several CPT-based methods have been proposed for the design of offshore driven piles in cohesionless soil such as the UWA-05, ICP-05, and NGI-99 methods. This article treats a case study where the API-method as well as the UWA-05 and NGI-99 methods are compared using CPT-data from an offshore...... location with dense to very dense sand. The design of the piles in the jacket foundation shows that API-00 for both the tension and the compression loads predicted much longer piles than the CPT-based methods. Variation of the pile length and pile diameter shows that NGI-99 and UWA-05 predicts almost...

  19. Chemotherapeutic agent CPT-11 eliminates peritoneal resident macrophages by inducing apoptosis.

    Science.gov (United States)

    Huang, Mei-Yun; Pan, Hao; Liang, Yi-Dan; Wei, Hong-Xia; Xu, Li-Hui; Zha, Qing-Bing; He, Xian-Hui; Ouyang, Dong-Yun

    2016-02-01

    CPT-11 (Irinotecan) is a first-line chemotherapeutic agent in clinic, but it may induce side effects including diarrhea and enteritis in patients. The underlying mechanism of CPT-11's intestinal toxicity is unclear. Peritoneal resident macrophages have been reported to be important for the maintenance of intestinal homeostasis. In this study, we evaluated the cytotoxic effects of CPT-11 on mouse peritoneal resident macrophages. CPT-11 was administered intraperitoneally to mice and their peritoneal exudate cells were isolated for evaluation. CPT-11 treatment strikingly decreased the ratio of F4/80(hi)MHCII(low) large peritoneal macrophages (LPMs), which are regarded as prenatally-originated peritoneal resident macrophages. Consistent with this, the transcription factor GATA6 specifically expressed in LPMs was barely detectable in the macrophages from CPT-11-treated mice, indicative of elimination of LPMs. Such elimination of LPMs was at least partly due to CPT-induced apoptosis in macrophages, because inhibition of apoptosis by caspase-3 inhibitor z-DEVD-fmk significantly diminished the loss of GATA6(+) LPMs. As GATA6 is a transcription factor that controls expression of multiple genes regulating peritoneal B-1 cell development and translocation, elimination of GATA6(+) LPMs led to a great reduction in B-1 cells in the peritoneal cavity after CPT-11 treatment. These results indicated that CPT-11-induced apoptosis contributed to the elimination of peritoneal resident macrophages, which might in turn impair the function of peritoneal B-1 cells in maintaining intestinal homeostasis. Our findings may at least partly explain why CPT-11 treatment in cancer patients induces diarrhea and enteritis, which may provide a novel avenue to prevent such side effects.

  20. Lorentz-violating vortex solutions in the CPT-even electrodynamics of the Standard Model Extension

    Energy Technology Data Exchange (ETDEWEB)

    Casana, Rodolfo; Ferreira Junior, Manoel M. [Universidade Federal do Maranhao (UFMA), MA (Brazil); Hora, E. da [Universidade Federal da Paraiba (UFPB), PB (Brazil)

    2011-07-01

    Full text: In this work, we investigate the formation of static rotationally symmetric solutions on the (1+3) dimensional CPT-even and Lorentz-violating photonic sector of the Standard Model Extension (SME). The main goal of this work is to show the possibility of obtaining these solutions, even in the presence of Lorentz-breaking fields. A secondary goal is to examine the effects of these fields on topologically non-trivial configurations. In order to obtain these results, we focus on specific components of Lorentz-violating background, dealing with static Euler-Lagrange equations, from which we fix temporal gauge (absence of electric field) as a proper gauge choice. We assume the usual rotationally symmetric Ansatz, inserting it in the Euler-Lagrange equations previously obtained. This Ansatz describes the Higgs and gauge fields via profile functions g(r) and a(r), respectively. From this Ansatz, we construct suitable boundary conditions near the origin. Also, we write the energy density in terms of these two profile functions, obtaining from it asymptotic boundary conditions. This set of conditions is used to numerically solve the Euler-Lagrange equations (by means of the shooting method). Finally, we plot solutions for some physical quantities (Higgs field, magnetic field and energy density) for several values of the Lorentz-violating parameters. From these plots, we discuss the influence of these coefficients on the topologically non-trivial rotationally symmetric configurations, focusing on the profiles of both magnetic field and energy density. (author)

  1. Search for Violation of CPT and Lorentz Invariance in $B^0_s$ Meson Oscillations using the D0 Detector

    CERN Document Server

    ,

    2016-01-01

    A search is presented for CPT-violating effects in the mixing of $B^0_s$ mesons using the D0 detector at the Fermilab Tevatron Collider. The CPT-violating asymmetry in the decay $B^0_s \\rightarrow \\mu^{\\pm} D_s^{\\mp} X$ as a function of sidereal phase is measured. No evidence for CPT-violating effects is observed and limits are placed on CPT- and Lorentz-invariance violating coupling coefficients.

  2. Undamped critical speeds of rotor systems using assumed modes

    Science.gov (United States)

    Nelson, H. D.; Chen, W. J.

    1993-07-01

    A procedure is presented to reduce the DOF of a discrete rotordynamics model by utilizing an assumed-modes Rayleigh-Ritz approximation. Many possibilities exist for the assumed modes and any reasonable choice will yield a reduced-order model with adequate accuracy for most applications. The procedure provides an option which can be implemented with relative ease and may prove beneficial for many applications where computational efficiency is particularly important.

  3. CeLAND: search for a 4th light neutrino state with a 3 PBq 144Ce-144Pr electron antineutrino generator in KamLAND

    CERN Document Server

    Gando, A; Hayashida, S; Ikeda, H; Inoue, K; Ishidoshiro, K; Ishikawa, H; Koga, M; Matsuda, R; Matsuda, S; Mitsui, T; Motoki, D; Nakamura, K; Oki, Y; Otani, M; Shimizu, I; Shirai, J; Suekane, F; Suzuki, A; Takemoto, Y; Tamae, K; Ueshima, K; Watanabe, H; Xu, B D; Yamada, S; Yamauchi, Y; Yoshida, H; Cribier, M; Durero, M; Fischer, V; Gaffiot, J; Jonqueres, N; Kouchner, A; Lasserre, T; Leterme, D; Letourneau, A; Lhuillier, D; Mention, G; Rampal, G; Scola, L; Veyssiere, Ch; Vivier, M; Yala, P; Berger, B E; Kozlov, A; Banks, T; Dwyer, D; Fujikawa, B K; Han, K; Kolomensky, Yu G; Mei, Y; O'Donnell, T; Decowski, P; Markoff, D M; Yoshida, S; Kornoukhov, V N; Gelis, T V M; Tikhomirov, G V; Learned, J G; Maricic, J; Matsuno, S; Milincic, R; Karwowski, H J; Efremenko, Y; Detwiler, A; Enomoto, S

    2013-01-01

    The reactor neutrino and gallium anomalies can be tested with a 3-4 PBq (75-100 kCi scale) 144Ce-144Pr antineutrino beta-source deployed at the center or next to a large low-background liquid scintillator detector. The antineutrino generator will be produced by the Russian reprocessing plant PA Mayak as early as 2014, transported to Japan, and deployed in the Kamioka Liquid Scintillator Anti-Neutrino Detector (KamLAND) as early as 2015. KamLAND's 13 m diameter target volume provides a suitable environment to measure the energy and position dependence of the detected neutrino flux. A characteristic oscillation pattern would be visible for a baseline of about 10 m or less, providing a very clean signal of neutrino disappearance into a yet-unknown, sterile neutrino state. This will provide a comprehensive test of the electron dissaperance neutrino anomalies and could lead to the discovery of a 4th neutrino state for Delta_m^2 > 0.1 eV^2 and sin^2(2theta) > 0.05.

  4. Intestinal glucuronidation protects against chemotherapy-induced toxicity by irinotecan (CPT-11).

    Science.gov (United States)

    Chen, Shujuan; Yueh, Mei-Fei; Bigo, Cyril; Barbier, Olivier; Wang, Kepeng; Karin, Michael; Nguyen, Nghia; Tukey, Robert H

    2013-11-19

    Camptothecin (CPT)-11 (irinotecan) has been used widely for cancer treatment, particularly metastatic colorectal cancer. However, up to 40% of treated patients suffer from severe late diarrhea, which prevents CPT-11 dose intensification and efficacy. CPT-11 is a prodrug that is hydrolyzed by hepatic and intestinal carboxylesterase to form SN-38, which in turn is detoxified primarily through UDP-glucuronosyltransferase 1A1 (UGT1A1)-catalyzed glucuronidation. To better understand the mechanism associated with toxicity, we generated tissue-specific Ugt1 locus conditional knockout mouse models and examined the role of glucuronidation in protecting against irinotecan-induced toxicity. We targeted the deletion of the Ugt1 locus and the Ugt1a1 gene specifically in the liver (Ugt1(ΔHep)) and the intestine (Ugt1(ΔGI)). Control (Ugt1(F/F)), Ugt1(ΔHep), and Ugt1(ΔGI) adult male mice were treated with different concentrations of CPT-11 daily for four consecutive days. Toxicities were evaluated with regard to tissue glucuronidation potential. CPT-11-treated Ugt1(ΔHep) mice showed a similar lethality rate to the CPT-11-treated Ugt1(F/F) mice. However, Ugt1(ΔGI) mice were highly susceptible to CPT-11-induced diarrhea, developing severe and lethal mucositis at much lower CPT-11 doses, a result of the proliferative cell loss and inflammation in the intestinal tract. Comparative expression levels of UGT1A1 in intestinal tumors and normal surrounding tissue are dramatically different, providing for the opportunity to improve therapy by differential gene regulation. Intestinal expression of the UGT1A proteins is critical toward the detoxification of SN-38, whereas induction of the UGT1A1 gene may serve to limit toxicity and improve the efficacy associated with CPT-11 treatment.

  5. Search for Lorentz and CPT Violation Effects in Muon Spin Precession

    CERN Document Server

    Bennett, G W; Brown, H N; Bunce, G; Carey, R M; Cushman, P; Danby, G T; Debevec, P T; Deile, M; Deng, H; Deninger, W; Dhawan, S K; Druzhinin, V P; Duong, L; Efstathiadis, E; Farley, F J M; Fedotovich, G V; Giron, S; Gray, F E; Grigoriev, D; Grosse-Perdekamp, M; Grossmann, A; Hare, M F; Hertzog, D W; Huang, X; Hughes, V W; Iwasaki, M; Jungmann, K; Kawall, D; Kawamura, M; Khazin, B I; Kindem, J; Krienen, F; Kronkvist, I; Lam, A; Larsen, R; Lee, Y Y; Logashenko, I; McNabb, R; Meng, W; Mi, J; Miller, J P; Mizumachi, Y; Morse, W M; Nikas, D; Onderwater, C J G; Orlov, Y; Ozben, C S; Paley, J M; Peng, Q; Polly, C C; Pretz, J; Prigl, R; zu Putlitz, G; Qian, T; Redin, S I; Rind, O; Roberts, B L; Ryskulov, N; Sedykh, S; Semertzidis, Y K; Shagin, P; Shatunov, Yu M; Sichtermann, E P; Solodov, E; Sossong, M; Steinmetz, A; Sulak, L R; Timmermans, C; Trofimov, A; Urner, D; von Walter, P; Warburton, D; Winn, D; Yamamoto, A; Zimmerman, D

    2007-01-01

    The spin precession frequency of muons stored in the (g-2) precision storage ring has been analyzed for evidence of Lorentz and CPT violation. Two Lorentz and CPT violation signatures were searched for: a nonzero \\Delta\\omega_a =\\omega_a ^\\mu^{+} - \\omega_{a}^\\mu^{-} ; and a sidereal variation of \\omega_{a}^\\mu^{\\pm}. No significant effect is found, and several limits on Lorentz and CPT violating parameters for positive and negative muons are set at the level of \\sim 10^{-23} - 10^{-24} GeV.

  6. Separate T, CP, CPT Asymmetries in Neutral Meson Transitions

    Science.gov (United States)

    Bernabéu, José

    2017-07-01

    Symmetries, and Symmetry Breakings, in the Laws of Physics play a crucial role in Fundamental Science. Parity and Charge Conjugation Violations prompted the consideration of Chiral Fields in the construction of the Standard Model, whereas CP-Violation needed at least three families of Quarks leading to Flavour Physics. In this Lecture I will discuss the Conceptual Basis and the present experimental results for a Direct Evidence of Separate Reversal-in-Time T, CP and CPT Genuine Asymmetries in Decaying Particles like Neutral Meson Transitions, using Quantum Entanglement and the Decay as a Filtering Measurement. The eight transitions associated to the Flavour-CP eigenstate decay products of entangled neutral mesons have demonstrated with impressive significance a separate evidence of TRV and CPV in Bd-physics, whereas a CPTV asymmetry shows a 2-σ effect interpreted as an upper limit. Novel CPTV observables are discussed for K and Bd transitions. Their observation would lead to a change of paradigm beyond Quantum Field Theory, however there is nothing in Quantum Mechanics forbidding CPTV. A clean methodology to disentangle CPTV effects in the Hamiltonian dynamics and the ω-effect weakening Entanglement in a given experiment is discussed.

  7. Checking T and CPT violation with sterile neutrino

    CERN Document Server

    Pant, Yogita; Singh, Jyotsna; Singh, R B

    2015-01-01

    Post LSND results, sterile neutrinos have drawn attention and motivated the high energy physics, astronomy and cosmology to probe physics beyond the standard model considering minimal 3+1 (3 active and 1 sterile) to 3+N neutrino schemes. The analytical equations for neutrino conversion probabilities are devloped in this work for 3+1 neutrino scheme. Here we have tried to explore the possible signals of T and CPT violations with four flavor neutrino scheme at neutrino factory. To investigate the T violation we have taken into consideration the golden and discovery channels. In our analysis the optimal values of Jarlskog factor for discovery channel coming from the constrained values of sterile parameters from long baseline and short baseline experiments are 0.169 and 0.163 respectively. Whereas the values of Jarlskog factor for golden channel are 0.0131 and 0.0143 coming from long and short baseline constraints respectively. This obesrevation promotes discovery channel to be the potential channel for probing T...

  8. Bayesian modeling growth curves for quail assuming skewness in errors

    Directory of Open Access Journals (Sweden)

    Robson Marcelo Rossi

    2014-06-01

    Full Text Available Bayesian modeling growth curves for quail assuming skewness in errors - To assume normal distributions in the data analysis is common in different areas of the knowledge. However we can make use of the other distributions that are capable to model the skewness parameter in the situations that is needed to model data with tails heavier than the normal. This article intend to present alternatives to the assumption of the normality in the errors, adding asymmetric distributions. A Bayesian approach is proposed to fit nonlinear models when the errors are not normal, thus, the distributions t, skew-normal and skew-t are adopted. The methodology is intended to apply to different growth curves to the quail body weights. It was found that the Gompertz model assuming skew-normal errors and skew-t errors, respectively for male and female, were the best fitted to the data.

  9. Search for Violation of $CPT$ and Lorentz invariance in ${B_s^0}$ meson oscillations

    CERN Document Server

    Abazov, Victor Mukhamedovich; Acharya, Bannanje Sripath; Adams, Mark Raymond; Adams, Todd; Agnew, James P; Alexeev, Guennadi D; Alkhazov, Georgiy D; Alton, Andrew K; Askew, Andrew Warren; Atkins, Scott; Augsten, Kamil; Avila, Carlos A; Badaud, Frederique; Bagby, Linda F; Baldin, Boris; Bandurin, Dmitry V; Banerjee, Sunanda; Barberis, Emanuela; Baringer, Philip S; Bartlett, JFrederick; Bassler, Ursula Rita; Bazterra, Victor; Bean, Alice L; Begalli, Marcia; Bellantoni, Leo; Beri, Suman B; Bernardi, Gregorio; Bernhard, Ralf Patrick; Bertram, Iain A; Besancon, Marc; Beuselinck, Raymond; Bhat, Pushpalatha C; Bhatia, Sudeep; Bhatnagar, Vipin; Blazey, Gerald Charles; Blessing, Susan K; Bloom, Kenneth A; Boehnlein, Amber S; Boline, Daniel Dooley; Boos, Edward E; Borissov, Guennadi; Borysova, Maryna; Brandt, Andrew; Brandt, Oleg; Brock, Raymond L; Bross, Alan D; Brown, Duncan Paul; Bu, Xue-Bing; Buehler, Marc; Buescher, Volker; Bunichev, Viacheslav Yevgenyevich; Burdin, Sergey; Buszello, Claus Peter; Camacho-Perez, Enrique; Casey, Brendan Cameron Kieran; Castilla-Valdez, Heriberto; Caughron, Seth Aaron; Chakrabarti, Subhendu; Chan, Kwok Ming Leo; Chandra, Avdhesh; Chapon, Emilien; Chen, Guo; Cho, Sung-Woong; Choi, Suyong; Choudhary, Brajesh C; Cihangir, Selcuk; Claes, Daniel R; Clutter, Justace Randall; Cooke, Michael P; Cooper, William Edward; Corcoran, Marjorie D; Couderc, Fabrice; Cousinou, Marie-Claude; Cuth, Jakub; Cutts, David; Das, Amitabha; Davies, Gavin John; de Jong, Sijbrand Jan; De La Cruz-Burelo, Eduard; Deliot, Frederic; Demina, Regina; Denisov, Dmitri S; Denisov, Sergei P; Desai, Satish Vijay; Deterre, Cecile; DeVaughan, Kayle Otis; Diehl, HThomas; Diesburg, Michael; Ding, Pengfei; Dominguez, DAaron M; Dubey, Abhinav Kumar; Dudko, Lev V; Duperrin, Arnaud; Dutt, Suneel; Eads, Michael T; Edmunds, Daniel L; Ellison, John A; Elvira, VDaniel; Enari, Yuji; Evans, Harold G; Evdokimov, Anatoly V; Evdokimov, Valeri N; Faure, Alexandre; Feng, Lei; Ferbel, Thomas; Fiedler, Frank; Filthaut, Frank; Fisher, Wade Cameron; Fisk, HEugene; Fortner, Michael R; Fox, Harald; Fuess, Stuart C; Garbincius, Peter H; Garcia-Bellido, Aran; Garcia-Gonzalez, Jose Andres; Gavrilov, Vladimir B; Geng, Weigang; Gerber, Cecilia Elena; Gershtein, Yuri S; Ginther, George E; Gogota, Olga; Golovanov, Georgy Anatolievich; Grannis, Paul D; Greder, Sebastien; Greenlee, Herbert B; Grenier, Gerald Jean; Gris, Phillipe Luc; Grivaz, Jean-Francois; Grohsjean, Alexander; Gruenendahl, Stefan; Gruenewald, Martin Werner; Guillemin, Thibault; Gutierrez, Gaston R; Gutierrez, Phillip; Haley, Joseph Glenn Biddle; Han, Liang; Harder, Kristian; Harel, Amnon; Hauptman, John Michael; Hays, Jonathan M; Head, Tim; Hebbeker, Thomas; Hedin, David R; Hegab, Hatim; Heinson, Ann; Heintz, Ulrich; Hensel, Carsten; Heredia-De La Cruz, Ivan; Herner, Kenneth Richard; Hesketh, Gavin G; Hildreth, Michael D; Hirosky, Robert James; Hoang, Trang; Hobbs, John D; Hoeneisen, Bruce; Hogan, Julie; Hohlfeld, Mark; Holzbauer, Jenny Lyn; Howley, Ian James; Hubacek, Zdenek; Hynek, Vlastislav; Iashvili, Ia; Ilchenko, Yuriy; Illingworth, Robert A; Ito, Albert S; Jabeen, Shabnam; Jaffre, Michel J; Jayasinghe, Ayesh; Jeong, Min-Soo; Jesik, Richard L; Jiang, Peng; Johns, Kenneth Arthur; Johnson, Emily; Johnson, Marvin E; Jonckheere, Alan M; Jonsson, Per Martin; Joshi, Jyoti; Jung, Andreas Werner; Juste, Aurelio; Kajfasz, Eric; Karmanov, Dmitriy Y; Katsanos, Ioannis; Kaur, Manbir; Kehoe, Robert Leo Patrick; Kermiche, Smain; Khalatyan, Norayr; Khanov, Alexander; Kharchilava, Avto; Kharzheev, Yuri N; Kiselevich, Ivan Lvovich; Kohli, Jatinder M; Kozelov, Alexander V; Kraus, James Alexander; Kumar, Ashish; Kupco, Alexander; Kurca, Tibor; Kuzmin, Valentin Alexandrovich; Lammers, Sabine Wedam; Lebrun, Patrice; Lee, Hyeon-Seung; Lee, Seh-Wook; Lee, William M; Lei, Xiaowen; Lellouch, Jeremie; Li, Dikai; Li, Hengne; Li, Liang; Li, Qi-Zhong; Lim, Jeong Ku; Lincoln, Donald W; Linnemann, James Thomas; Lipaev, Vladimir V; Lipton, Ronald J; Liu, Huanzhao; Liu, Yanwen; Lobodenko, Alexandre; Lokajicek, Milos; Lopes de Sa, Rafael; Luna-Garcia, Rene; Lyon, Adam Leonard; Maciel, Arthur KA; Madar, Romain; Magana-Villalba, Ricardo; Malik, Sudhir; Malyshev, Vladimir L; Mansour, Jason; Martinez-Ortega, Jorge; McCarthy, Robert L; Mcgivern, Carrie Lynne; Meijer, Melvin M; Melnitchouk, Alexander S; Menezes, Diego D; Mercadante, Pedro Galli; Merkin, Mikhail M; Meyer, Arnd; Meyer, Jorg Manfred; Miconi, Florian; Mondal, Naba K; Mulhearn, Michael James; Nagy, Elemer; Narain, Meenakshi; Nayyar, Ruchika

    2015-01-01

    We present the first search for CPT-violating effects in the mixing of ${B_s^0}$ mesons using the full Run II data set with an integrated luminosity of 10.4 fb$^{-1}$ of proton-antiproton collisions collected using the D0 detector at the Fermilab Tevatron Collider. We measure the CPT-violating asymmetry in the decay $B_s^0 \\to \\mu^\\pm D_s^\\pm$ as a function of celestial direction and sidereal phase. We find no evidence for CPT-violating effects and place limits on the direction and magnitude of flavor-dependent CPT- and Lorentz-invariance violating coupling coefficients. We find 95\\% confidence intervals of $\\Delta a_{\\perp} < 1.2 \\times 10^{-12}$ GeV and $(-0.8 < \\Delta a_T - 0.396 \\Delta a_Z < 3.9) \\times 10^{-13}$ GeV.

  10. Search for Violation of CPT and Lorentz Invariance in Bs(0) Meson Oscillations.

    Science.gov (United States)

    Abazov, V M; Abbott, B; Acharya, B S; Adams, M; Adams, T; Agnew, J P; Alexeev, G D; Alkhazov, G; Alton, A; Askew, A; Atkins, S; Augsten, K; Avila, C; Badaud, F; Bagby, L; Baldin, B; Bandurin, D V; Banerjee, S; Barberis, E; Baringer, P; Bartlett, J F; Bassler, U; Bazterra, V; Bean, A; Begalli, M; Bellantoni, L; Beri, S B; Bernardi, G; Bernhard, R; Bertram, I; Besançon, M; Beuselinck, R; Bhat, P C; Bhatia, S; Bhatnagar, V; Blazey, G; Blessing, S; Bloom, K; Boehnlein, A; Boline, D; Boos, E E; Borissov, G; Borysova, M; Brandt, A; Brandt, O; Brock, R; Bross, A; Brown, D; Bu, X B; Buehler, M; Buescher, V; Bunichev, V; Burdin, S; Buszello, C P; Camacho-Pérez, E; Casey, B C K; Castilla-Valdez, H; Caughron, S; Chakrabarti, S; Chan, K M; Chandra, A; Chapon, E; Chen, G; Cho, S W; Choi, S; Choudhary, B; Cihangir, S; Claes, D; Clutter, J; Cooke, M; Cooper, W E; Corcoran, M; Couderc, F; Cousinou, M-C; Cuth, J; Cutts, D; Das, A; Davies, G; de Jong, S J; De La Cruz-Burelo, E; Déliot, F; Demina, R; Denisov, D; Denisov, S P; Desai, S; Deterre, C; DeVaughan, K; Diehl, H T; Diesburg, M; Ding, P F; Dominguez, A; Dubey, A; Dudko, L V; Duperrin, A; Dutt, S; Eads, M; Edmunds, D; Ellison, J; Elvira, V D; Enari, Y; Evans, H; Evdokimov, A; Evdokimov, V N; Fauré, A; Feng, L; Ferbel, T; Fiedler, F; Filthaut, F; Fisher, W; Fisk, H E; Fortner, M; Fox, H; Fuess, S; Garbincius, P H; Garcia-Bellido, A; García-González, J A; Gavrilov, V; Geng, W; Gerber, C E; Gershtein, Y; Ginther, G; Gogota, O; Golovanov, G; Grannis, P D; Greder, S; Greenlee, H; Grenier, G; Gris, Ph; Grivaz, J-F; Grohsjean, A; Grünendahl, S; Grünewald, M W; Guillemin, T; Gutierrez, G; Gutierrez, P; Haley, J; Han, L; Harder, K; Harel, A; Hauptman, J M; Hays, J; Head, T; Hebbeker, T; Hedin, D; Hegab, H; Heinson, A P; Heintz, U; Hensel, C; Heredia-De La Cruz, I; Herner, K; Hesketh, G; Hildreth, M D; Hirosky, R; Hoang, T; Hobbs, J D; Hoeneisen, B; Hogan, J; Hohlfeld, M; Holzbauer, J L; Howley, I; Hubacek, Z; Hynek, V; Iashvili, I; Ilchenko, Y; Illingworth, R; Ito, A S; Jabeen, S; Jaffré, M; Jayasinghe, A; Jeong, M S; Jesik, R; Jiang, P; Johns, K; Johnson, E; Johnson, M; Jonckheere, A; Jonsson, P; Joshi, J; Jung, A W; Juste, A; Kajfasz, E; Karmanov, D; Katsanos, I; Kaur, M; Kehoe, R; Kermiche, S; Khalatyan, N; Khanov, A; Kharchilava, A; Kharzheev, Y N; Kiselevich, I; Kohli, J M; Kozelov, A V; Kraus, J; Kumar, A; Kupco, A; Kurča, T; Kuzmin, V A; Lammers, S; Lebrun, P; Lee, H S; Lee, S W; Lee, W M; Lei, X; Lellouch, J; Li, D; Li, H; Li, L; Li, Q Z; Lim, J K; Lincoln, D; Linnemann, J; Lipaev, V V; Lipton, R; Liu, H; Liu, Y; Lobodenko, A; Lokajicek, M; Lopes de Sa, R; Luna-Garcia, R; Lyon, A L; Maciel, A K A; Madar, R; Magaña-Villalba, R; Malik, S; Malyshev, V L; Mansour, J; Martínez-Ortega, J; McCarthy, R; McGivern, C L; Meijer, M M; Melnitchouk, A; Menezes, D; Mercadante, P G; Merkin, M; Meyer, A; Meyer, J; Miconi, F; Mondal, N K; Mulhearn, M; Nagy, E; Narain, M; Nayyar, R; Neal, H A; Negret, J P; Neustroev, P; Nguyen, H T; Nunnemann, T; Orduna, J; Osman, N; Osta, J; Pal, A; Parashar, N; Parihar, V; Park, S K; Partridge, R; Parua, N; Patwa, A; Penning, B; Perfilov, M; Peters, Y; Petridis, K; Petrillo, G; Pétroff, P; Pleier, M-A; Podstavkov, V M; Popov, A V; Prewitt, M; Price, D; Prokopenko, N; Qian, J; Quadt, A; Quinn, B; Ratoff, P N; Razumov, I; Ripp-Baudot, I; Rizatdinova, F; Rominsky, M; Ross, A; Royon, C; Rubinov, P; Ruchti, R; Sajot, G; Sánchez-Hernández, A; Sanders, M P; Santos, A S; Savage, G; Savitskyi, M; Sawyer, L; Scanlon, T; Schamberger, R D; Scheglov, Y; Schellman, H; Schott, M; Schwanenberger, C; Schwienhorst, R; Sekaric, J; Severini, H; Shabalina, E; Shary, V; Shaw, S; Shchukin, A A; Simak, V; Skubic, P; Slattery, P; Smirnov, D; Snow, G R; Snow, J; Snyder, S; Söldner-Rembold, S; Sonnenschein, L; Soustruznik, K; Stark, J; Stoyanova, D A; Strauss, M; Suter, L; Svoisky, P; Titov, M; Tokmenin, V V; Tsai, Y-T; Tsybychev, D; Tuchming, B; Tully, C; Uvarov, L; Uvarov, S; Uzunyan, S; Van Kooten, R; van Leeuwen, W M; Varelas, N; Varnes, E W; Vasilyev, I A; Verkheev, A Y; Vertogradov, L S; Verzocchi, M; Vesterinen, M; Vilanova, D; Vokac, P; Wahl, H D; Wang, M H L S; Warchol, J; Watts, G; Wayne, M; Weichert, J; Welty-Rieger, L; Williams, M R J; Wilson, G W; Wobisch, M; Wood, D R; Wyatt, T R; Xie, Y; Yamada, R; Yang, S; Yasuda, T; Yatsunenko, Y A; Ye, W; Ye, Z; Yin, H; Yip, K; Youn, S W; Yu, J M; Zennamo, J; Zhao, T G; Zhou, B; Zhu, J; Zielinski, M; Zieminska, D; Zivkovic, L

    2015-10-16

    We present the first search for CPT-violating effects in the mixing of Bs(0) mesons using the full Run II data set with an integrated luminosity of 10.4  fb(-1) of proton-antiproton collisions collected using the D0 detector at the Fermilab Tevatron Collider. We measure the CPT-violating asymmetry in the decay Bs(0)→μ(±)Ds(±) as a function of celestial direction and sidereal phase. We find no evidence for CPT-violating effects and place limits on the direction and magnitude of flavor-dependent CPT- and Lorentz-invariance violating coupling coefficients. We find 95% confidence intervals of Δa⊥<1.2×10(-12)  GeV and (-0.8<ΔaT-0.396ΔaZ<3.9)×10(-13)  GeV.

  11. Finite Temperature CPT-even Electrodynamics of the Standard Model Extension

    CERN Document Server

    Casana, Rodolfo; Rodrigues, Josberg S; Silva, Madson R O

    2009-01-01

    In this work, we examine the finite temperature properties of the non-birefringent coefficients of the CPT-even and Lorentz-invariance-violating (LIV) electrodynamics of the standard model extension, represented by the term $W_{\\alpha \

  12. Search for Violation of $CPT$ and Lorentz invariance in ${B_s^0}$ meson oscillations

    CERN Document Server

    Abazov, Victor Mukhamedovich; Acharya, Bannanje Sripath; Adams, Mark Raymond; Adams, Todd; Agnew, James P; Alexeev, Guennadi D; Alkhazov, Georgiy D; Alton, Andrew K; Askew, Andrew Warren; Atkins, Scott; Augsten, Kamil; Avila, Carlos A; Badaud, Frederique; Bagby, Linda F; Baldin, Boris; Bandurin, Dmitry V; Banerjee, Sunanda; Barberis, Emanuela; Baringer, Philip S; Bartlett, JFrederick; Bassler, Ursula Rita; Bazterra, Victor; Bean, Alice L; Begalli, Marcia; Bellantoni, Leo; Beri, Suman B; Bernardi, Gregorio; Bernhard, Ralf Patrick; Bertram, Iain A; Besancon, Marc; Beuselinck, Raymond; Bhat, Pushpalatha C; Bhatia, Sudeep; Bhatnagar, Vipin; Blazey, Gerald Charles; Blessing, Susan K; Bloom, Kenneth A; Boehnlein, Amber S; Boline, Daniel Dooley; Boos, Edward E; Borissov, Guennadi; Borysova, Maryna; Brandt, Andrew; Brandt, Oleg; Brock, Raymond L; Bross, Alan D; Brown, Duncan Paul; Bu, Xue-Bing; Buehler, Marc; Buescher, Volker; Bunichev, Viacheslav Yevgenyevich; Burdin, Sergey; Buszello, Claus Peter; Camacho-Perez, Enrique; Casey, Brendan Cameron Kieran; Castilla-Valdez, Heriberto; Caughron, Seth Aaron; Chakrabarti, Subhendu; Chan, Kwok Ming Leo; Chandra, Avdhesh; Chapon, Emilien; Chen, Guo; Cho, Sung-Woong; Choi, Suyong; Choudhary, Brajesh C; Cihangir, Selcuk; Claes, Daniel R; Clutter, Justace Randall; Cooke, Michael P; Cooper, William Edward; Corcoran, Marjorie D; Couderc, Fabrice; Cousinou, Marie-Claude; Cuth, Jakub; Cutts, David; Das, Amitabha; Davies, Gavin John; de Jong, Sijbrand Jan; De La Cruz-Burelo, Eduard; Deliot, Frederic; Demina, Regina; Denisov, Dmitri S; Denisov, Sergei P; Desai, Satish Vijay; Deterre, Cecile; DeVaughan, Kayle Otis; Diehl, HThomas; Diesburg, Michael; Ding, Pengfei; Dominguez, DAaron M; Dubey, Abhinav Kumar; Dudko, Lev V; Duperrin, Arnaud; Dutt, Suneel; Eads, Michael T; Edmunds, Daniel L; Ellison, John A; Elvira, VDaniel; Enari, Yuji; Evans, Harold G; Evdokimov, Anatoly V; Evdokimov, Valeri N; Faure, Alexandre; Feng, Lei; Ferbel, Thomas; Fiedler, Frank; Filthaut, Frank; Fisher, Wade Cameron; Fisk, HEugene; Fortner, Michael R; Fox, Harald; Fuess, Stuart C; Garbincius, Peter H; Garcia-Bellido, Aran; Garcia-Gonzalez, Jose Andres; Gavrilov, Vladimir B; Geng, Weigang; Gerber, Cecilia Elena; Gershtein, Yuri S; Ginther, George E; Gogota, Olga; Golovanov, Georgy Anatolievich; Grannis, Paul D; Greder, Sebastien; Greenlee, Herbert B; Grenier, Gerald Jean; Gris, Phillipe Luc; Grivaz, Jean-Francois; Grohsjean, Alexander; Gruenendahl, Stefan; Gruenewald, Martin Werner; Guillemin, Thibault; Gutierrez, Gaston R; Gutierrez, Phillip; Haley, Joseph Glenn Biddle; Han, Liang; Harder, Kristian; Harel, Amnon; Hauptman, John Michael; Hays, Jonathan M; Head, Tim; Hebbeker, Thomas; Hedin, David R; Hegab, Hatim; Heinson, Ann; Heintz, Ulrich; Hensel, Carsten; Heredia-De La Cruz, Ivan; Herner, Kenneth Richard; Hesketh, Gavin G; Hildreth, Michael D; Hirosky, Robert James; Hoang, Trang; Hobbs, John D; Hoeneisen, Bruce; Hogan, Julie; Hohlfeld, Mark; Holzbauer, Jenny Lyn; Howley, Ian James; Hubacek, Zdenek; Hynek, Vlastislav; Iashvili, Ia; Ilchenko, Yuriy; Illingworth, Robert A; Ito, Albert S; Jabeen, Shabnam; Jaffre, Michel J; Jayasinghe, Ayesh; Jeong, Min-Soo; Jesik, Richard L; Jiang, Peng; Johns, Kenneth Arthur; Johnson, Emily; Johnson, Marvin E; Jonckheere, Alan M; Jonsson, Per Martin; Joshi, Jyoti; Jung, Andreas Werner; Juste, Aurelio; Kajfasz, Eric; Karmanov, Dmitriy Y; Katsanos, Ioannis; Kaur, Manbir; Kehoe, Robert Leo Patrick; Kermiche, Smain; Khalatyan, Norayr; Khanov, Alexander; Kharchilava, Avto; Kharzheev, Yuri N; Kiselevich, Ivan Lvovich; Kohli, Jatinder M; Kozelov, Alexander V; Kraus, James Alexander; Kumar, Ashish; Kupco, Alexander; Kurca, Tibor; Kuzmin, Valentin Alexandrovich; Lammers, Sabine Wedam; Lebrun, Patrice; Lee, Hyun-Su; Lee, Seh-Wook; Lee, William M; Lei, Xiaowen; Lellouch, Jeremie; Li, Dikai; Li, Hengne; Li, Liang; Li, Qi-Zhong; Lim, Jeong Ku; Lincoln, Donald W; Linnemann, James Thomas; Lipaev, Vladimir V; Lipton, Ronald J; Liu, Huanzhao; Liu, Yanwen; Lobodenko, Alexandre; Lokajicek, Milos; Lopes de Sa, Rafael; Luna-Garcia, Rene; Lyon, Adam Leonard; Maciel, Arthur KA; Madar, Romain; Magana-Villalba, Ricardo; Malik, Sudhir; Malyshev, Vladimir L; Mansour, Jason; Martinez-Ortega, Jorge; McCarthy, Robert L; Mcgivern, Carrie Lynne; Meijer, Melvin M; Melnitchouk, Alexander S; Menezes, Diego D; Mercadante, Pedro Galli; Merkin, Mikhail M; Meyer, Arnd; Meyer, Jorg Manfred; Miconi, Florian; Mondal, Naba K; Mulhearn, Michael James; Nagy, Elemer; Narain, Meenakshi; Nayyar, Ruchika; Neal, Homer A; Negret, Juan Pablo; Neustroev, Petr V; Nguyen, Huong Thi; Nunnemann, Thomas P; Orduna, Jose de Jesus Hernandez; Osman, Nicolas Ahmed; Osta, Jyotsna; Pal, Arnab; Parashar, Neeti; Parihar, Vivek; Park, Sung Keun; Partridge, Richard A; Parua, Nirmalya; Patwa, Abid; Penning, Bjoern; Perfilov, Maxim Anatolyevich; Peters, Reinhild Yvonne Fatima; Petridis, Konstantinos; Petrillo, Gianluca; Petroff, Pierre; Pleier, Marc-Andre; Podstavkov, Vladimir M; Popov, Alexey V; Prewitt, Michelle; Price, Darren; Prokopenko, Nikolay N; Qian, Jianming; Quadt, Arnulf; Quinn, Gene Breese; Ratoff, Peter N; Razumov, Ivan A; Ripp-Baudot, Isabelle; Rizatdinova, Flera; Rominsky, Mandy Kathleen; Ross, Anthony; Royon, Christophe; Rubinov, Paul Michael; Ruchti, Randal C; Sajot, Gerard; Sanchez-Hernandez, Alberto; Sanders, Michiel P; Santos, Angelo Souza; Savage, David G; Savitskyi, Mykola; Sawyer, HLee; Scanlon, Timothy P; Schamberger, RDean; Scheglov, Yury A; Schellman, Heidi M; Schott, Matthias; Schwanenberger, Christian; Schwienhorst, Reinhard H; Sekaric, Jadranka; Severini, Horst; Shabalina, Elizaveta K; Shary, Viacheslav V; Shaw, Savanna; Shchukin, Andrey A; Simak, Vladislav J; Skubic, Patrick Louis; Slattery, Paul F; Smirnov, Dmitri V; Snow, Gregory R; Snow, Joel Mark; Snyder, Scott Stuart; Soldner-Rembold, Stefan; Sonnenschein, Lars; Soustruznik, Karel; Stark, Jan; Stoyanova, Dina A; Strauss, Michael G; Suter, Louise; Svoisky, Peter V; Titov, Maxim; Tokmenin, Valeriy V; Tsai, Yun-Tse; Tsybychev, Dmitri; Tuchming, Boris; Tully, Christopher George T; Uvarov, Lev; Uvarov, Sergey L; Uzunyan, Sergey A; Van Kooten, Richard J; van Leeuwen, Willem M; Varelas, Nikos; Varnes, Erich W; Vasilyev, Igor A; Verkheev, Alexander Yurievich; Vertogradov, Leonid S; Verzocchi, Marco; Vesterinen, Mika; Vilanova, Didier; Vokac, Petr; Wahl, Horst D; Wang, Michael HLS; Warchol, Jadwiga; Watts, Gordon Thomas; Wayne, Mitchell R; Weichert, Jonas; Welty-Rieger, Leah Christine; Williams, Mark Richard James; Wilson, Graham Wallace; Wobisch, Markus; Wood, Darien Robert; Wyatt, Terence R; Xie, Yunhe; Yamada, Ryuji; Yang, Siqi; Yasuda, Takahiro; Yatsunenko, Yuriy A; Ye, Wanyu; Ye, Zhenyu; Yin, Hang; Yip, Kin; Youn, Sungwoo; Yu, Jiaming; Zennamo, Joseph; Zhao, Tianqi Gilbert; Zhou, Bing; Zhu, Junjie; Zielinski, Marek; Zieminska, Daria; Zivkovic, Lidija

    2015-01-01

    We present the first search for CPT-violating effects in the mixing of ${B_s^0}$ mesons using the full Run II data set with an integrated luminosity of 10.4 fb$^{-1}$ of proton-antiproton collisions collected using the D0 detector at the Fermilab Tevatron Collider. We measure the CPT-violating asymmetry in the decay $B_s^0 \\to \\mu^\\pm D_s^\\pm$ as a function of celestial direction and sidereal phase. We find no evidence for CPT-violating effects and place limits on the direction and magnitude of flavor-dependent CPT- and Lorentz-invariance violating coupling coefficients. We find 95\\% confidence intervals of $\\Delta a_{\\perp} < 1.2 \\times 10^{-12}$ GeV and $(-0.8 < \\Delta a_T - 0.396 \\Delta a_Z < 3.9) \\times 10^{-13}$ GeV.

  13. On Dirac-like Monopoles in a Lorentz- and CPT-violating Electrodynamics

    CERN Document Server

    Barraz, N M; Moura-Melo, W A; Helay"el-Neto, J A

    2007-01-01

    We study magnetic monopoles in a Lorentz- and CPT-odd electrodynamical framework in (3+1) dimensions. This is the standard Maxwell model extended by means of a Chern-Simons-like term, $b_\\mu\\tilde{F}^{\\mu\

  14. Mutation and biochemical analysis in carnitine palmitoyltransferase type II (CPT II) deficiency

    DEFF Research Database (Denmark)

    Olpin, S E; Afifi, A; Clark, S

    2003-01-01

    Carnitine palmitoyltransferase type II (CPT II) deficiency has three basic phenotypes, late-onset muscular (mild), infantile/juvenile hepatic (intermediate) and severe neonatal. We have measured fatty acid oxidation and CPT II activity and performed mutation studies in 24 symptomatic patients......, the implication being that they may significantly influence the manifestation of clinical disease and could therefore potentially be considered as a susceptibility variants. Among myopathic individuals, males comprised 88% of patients, suggesting increased susceptibility to clinical disease. A small number...

  15. Crystal Structure of the Geobacillus stearothermophilus Carboxylesterase Est55 and Its Activation of Prodrug CPT-11

    OpenAIRE

    Liu, Ping; Ewis, Hosam E.; Tai, Phang C.; Lu, Chung-Dar; Weber, Irene T.

    2006-01-01

    Several mammalian carboxylesterases were shown to activate the prodrug irinotecan (CPT-11) to produce SN-38, a topoisomerase inhibitor used in cancer therapy. However, the potential use of bacterial carboxylesterases, which have the advantage of high stability, has not been explored. We present the crystal structure of the carboxyesterase Est55 from Geobacillus stearothermophilus and evaluation of its enzyme activity on CPT-11. Crystal structures were determined at pH 6.2 and 6.8 and resoluti...

  16. DEFORMATION RIGIDITY OF ASSUMED STRESS MODES IN HYBRID ELEMENTS

    Institute of Scientific and Technical Information of China (English)

    ZHANG Can-hui; HUANG Qian; FENG Wei

    2006-01-01

    The new methods to determine the zero-energy deformation modes in the hybrid elements and the zero-energy stress modes in their assumed stress fields are presented by the natural deformation modes of the elements. And the formula of the additional element deformation rigidity due to additional mode into the assumed stress field is derived.Based on, it is concluded in theory that the zero-energy stress mode cannot suppress the zero-energy deformation modes but increase the extra rigidity to the nonzero-energy deformation modes of the element instead. So they should not be employed to assume the stress field. In addition, the parasitic stress modes will produce the spurious parasitic energy and result the element behaving over rigidity. Thus, they should not be used into the assumed stress field even though they can suppress the zero-energy deformation modes of the element. The numerical examples show the performance of the elements including the zero-energy stress modes or the parasitic stress modes.

  17. Statistical motor number estimation assuming a binomial distribution.

    NARCIS (Netherlands)

    Blok, J.H.; Visser, G.H.A.; Graaf, S.S.N. de; Zwarts, M.J.; Stegeman, D.F.

    2005-01-01

    The statistical method of motor unit number estimation (MUNE) uses the natural stochastic variation in a muscle's compound response to electrical stimulation to obtain an estimate of the number of recruitable motor units. The current method assumes that this variation follows a Poisson distribution.

  18. Status and prospects for CPT and Lorentz invariance violation searches in neutral meson mixing

    Directory of Open Access Journals (Sweden)

    Jeroen van Tilburg

    2015-03-01

    Full Text Available An overview of current experimental bounds on CPT violation in neutral meson mixing is given. New values for the CPT asymmetry in the B0 and Bs0 systems are deduced from published BaBar, Belle and LHCb results. With dedicated analyses, LHCb will be able to further improve the bounds on CPT violation in the D0, B0 and Bs0 systems. Since CPT violation implies violation of Lorentz invariance in an interacting local quantum field theory, the observed CPT asymmetry will exhibit sidereal- and boost-dependent variations. Such CPT-violating and Lorentz-violating effects are accommodated in the framework of the Standard Model Extension (SME. The large boost of the neutral mesons produced at LHCb results in a high sensitivity to the corresponding SME coefficients. For the B0 and Bs0 systems, using existing LHCb results, we determine with high precision the SME coefficients that are not varying with sidereal time. With a full sidereal analysis, LHCb will be able to improve the existing SME bounds in the D0, B0 and Bs0 systems by up to two orders of magnitude.

  19. Modeling turbulent/chemistry interactions using assumed pdf methods

    Science.gov (United States)

    Gaffney, R. L, Jr.; White, J. A.; Girimaji, S. S.; Drummond, J. P.

    1992-01-01

    Two assumed probability density functions (pdfs) are employed for computing the effect of temperature fluctuations on chemical reaction. The pdfs assumed for this purpose are the Gaussian and the beta densities of the first kind. The pdfs are first used in a parametric study to determine the influence of temperature fluctuations on the mean reaction-rate coefficients. Results indicate that temperature fluctuations significantly affect the magnitude of the mean reaction-rate coefficients of some reactions depending on the mean temperature and the intensity of the fluctuations. The pdfs are then tested on a high-speed turbulent reacting mixing layer. Results clearly show a decrease in the ignition delay time due to increases in the magnitude of most of the mean reaction rate coefficients.

  20. Automated Assume-Guarantee Reasoning by Abstraction Refinement

    Science.gov (United States)

    Pasareanu, Corina S.; Giannakopoulous, Dimitra; Glannakopoulou, Dimitra

    2008-01-01

    Current automated approaches for compositional model checking in the assume-guarantee style are based on learning of assumptions as deterministic automata. We propose an alternative approach based on abstraction refinement. Our new method computes the assumptions for the assume-guarantee rules as conservative and not necessarily deterministic abstractions of some of the components, and refines those abstractions using counter-examples obtained from model checking them together with the other components. Our approach also exploits the alphabets of the interfaces between components and performs iterative refinement of those alphabets as well as of the abstractions. We show experimentally that our preliminary implementation of the proposed alternative achieves similar or better performance than a previous learning-based implementation.

  1. Chemically reacting supersonic flow calculation using an assumed PDF model

    Science.gov (United States)

    Farshchi, M.

    1990-01-01

    This work is motivated by the need to develop accurate models for chemically reacting compressible turbulent flow fields that are present in a typical supersonic combustion ramjet (SCRAMJET) engine. In this paper the development of a new assumed probability density function (PDF) reaction model for supersonic turbulent diffusion flames and its implementation into an efficient Navier-Stokes solver are discussed. The application of this model to a supersonic hydrogen-air flame will be considered.

  2. Assume-Guarantee Synthesis for Digital Contract Signing

    CERN Document Server

    Chatterjee, Krishnendu

    2010-01-01

    We study the automatic synthesis of fair non-repudiation protocols, a class of fair exchange protocols, used for digital contract signing. First, we show how to specify the objectives of the participating agents and the trusted third party (TTP) as path formulas in LTL and prove that the satisfaction of these objectives imply fairness and abuse-freeness; properties required of fair exchange protocols. We then show that weak (co-operative) co-synthesis and classical (strictly competitive) co-synthesis fail, whereas assume-guarantee synthesis (AGS) succeeds. We demonstrate the success of assume-guarantee synthesis as follows: (a) any solution of assume-guarantee synthesis is attack-free; no subset of participants can violate the objectives of the other participants; (b) the Asokan-Shoup-Waidner (ASW) certified mail protocol that has known vulnerabilities is not a solution of AGS; (c) The Garay-Jakobsson-MacKenzie (GJM) protocol, while fair and abuse-free, is not attack-free by our definition and is hence not a ...

  3. Expression of a cDNA isolated from rat brown adipose tissue and heart identifies the product as the muscle isoform of carnitine palmitoyltransferase I (M-CPT I). M-CPT I is the predominant CPT I isoform expressed in both white (epididymal) and brown adipocytes.

    Science.gov (United States)

    Esser, V; Brown, N F; Cowan, A T; Foster, D W; McGarry, J D

    1996-03-22

    We set out to determine if the cDNA encoding a carnitine palmitoyltransferase (CPT)-like protein recently isolated from rat brown adipose tissue (BAT) by Yamazaki et al. (Yamazaki, N., Shinohara, Y., Shima, A., and Terada, H. (1995) FEBS Lett. 363, 41-45) actually encodes the muscle isoform of mitochondrial CPT I (M-CPT I). To this end, a cDNA essentially identical to the original BAT clone was isolated from a rat heart library. When expressed in COS cells, the novel cDNA and our previously described cDNA for rat liver CPT I (L-CPT I) gave rise to products with the same kinetic characteristics (sensitivity to malonyl-CoA and Km for carnitine) as CPT I in skeletal muscle and liver mitochondria, respectively. When labeled with [3H]etomoxir, recombinant L-CPT I and putative M-CPT I, although having approximately the same predicated masses (88.2 kDa), migrated differently on SDS gels, as did CPT I from liver and muscle mitochondria. The same was true for the products of in vitro transcription and translation of the L-CPT I and putative M-CPT I cDNAs. We conclude that the BAT cDNA does in fact encode M-CPT I. Northern blots using L- and M-CPT I cDNA probes revealed the presence of L-CPT I mRNA in liver and heart and its absence from skeletal muscle and BAT. M-CPT I mRNA, which was absent from liver, was readily detected in skeletal muscle and was particularly strong in heart and BAT. Whereas the signal for L-CPT I was more abundant than that for M-CPT I in RNA isolated from whole epididymal fat pad, this was reversed in purified adipocytes from this source. These findings, coupled with the kinetic properties and migration profiles on SDS gels of CPT I in brown and white adipocytes, indicate that the muscle form of the enzyme is the dominant, if not exclusive, species in both cell types.

  4. Intestinal alkalization as a possible preventive mechanism in irinotecan (CPT-11)-induced diarrhea.

    Science.gov (United States)

    Ikegami, Tadashi; Ha, Linan; Arimori, Kazuhiko; Latham, Patricia; Kobayashi, Kunihiko; Ceryak, Susan; Matsuzaki, Yasushi; Bouscarel, Bernard

    2002-01-01

    The therapeutic efficacy of irinotecan (CPT-11), a DNA topoisomerase inhibitor, is often limited by the induction of severe late-onset diarrhea. This prodrug and its active metabolite, 7-ethyl-10-hydroxy-camptothecin (SN-38), have a labile alpha-hydroxy-lactone ring that undergoes pH-dependent reversible hydrolysis. At physiological pH and higher, equilibrium favors the less toxic carboxylate form, whereas at acidic pH, the more potent lactone form is favored. We have reported previously that the initial uptake rate of CPT-11 and SN-38 by intestinal cells was significantly different between the respective lactone and carboxylate form. Results from the present study in HT-29 cells further demonstrate the correlation between the CPT-11/SN-38 initial uptake rate and the induced toxicity, cell cycle alteration, apoptosis, and colony-forming efficiency. The exposure of HT-29 cells to SN-38 for a limited period of time (carboxylate resulted in a reduced cellular toxicity, we postulated that the CPT-11-induced diarrhea was preventable by influencing the equilibrium toward the carboxylate form and, thus, reducing its intestinal uptake. In the golden Syrian hamster model, p.o. sodium bicarbonate supplementation (5 mg/ml in drinking water) led to alkalization of the intestinal contents. In addition, this alkalization resulted in the reduction of the histopathological damage to the mucosa of the small and large intestine, as well as a 20% reduction of the intestinal SN-38 lactone concentration of animals receiving CPT-11 (20-50 mg/kg x 7 days). Taken together, these results from in vitro and in vivo studies support intestinal alkalization by sodium bicarbonate supplementation as a preventive mechanism against CPT-11-induced diarrhea. In addition, this provides a strong rationale for the usage of this measure as an adjunct to CPT-11 treatment.

  5. Effect of Cellular Location of Human Carboxylesterase 2 on CPT-11 Hydrolysis and Anticancer Activity.

    Directory of Open Access Journals (Sweden)

    Yuan-Ting Hsieh

    Full Text Available CPT-11 is an anticancer prodrug that is clinically used for the treatment of metastatic colorectal cancer. Hydrolysis of CPT-11 by human carboxylesterase 2 (CE2 generates SN-38, a topoisomerase I inhibitor that is the active anti-tumor agent. Expression of CE2 in cancer cells is under investigation for the tumor-localized activation of CPT-11. CE2 is normally expressed in the endoplasmic reticulum of cells but can be engineered to direct expression of active enzyme on the plasma membrane or as a secreted form. Although previous studies have investigated different locations of CE2 expression in cancer cells, it remains unclear if CE2 cellular location affects CPT-11 anticancer activity. In the present study, we directly compared the influence of CE2 cellular location on substrate hydrolysis and CPT-11 cytotoxicity. We linked expression of CE2 and enhanced green fluorescence protein (eGFP via a foot-and-mouth disease virus 2A (F2A peptide to facilitate fluorescence-activated cell sorting to achieve similar expression levels of ER-located, secreted or membrane-anchored CE2. Soluble CE2 was detected in the medium of cells that expressed secreted and membrane-anchored CE2, but not in cells that expressed ER-retained CE2. Cancer cells that expressed all three forms of CE2 were more sensitive to CPT-11 as compared to unmodified cancer cells, but the membrane-anchored and ER-retained forms of CE2 were consistently more effective than secreted CE2. We conclude that expression of CE2 in the ER or on the membrane of cancer cells is suitable for enhancing CPT-11 anticancer activity.

  6. CPT1A methylation is associated with plasma adiponectin.

    Science.gov (United States)

    Aslibekyan, S; Do, A N; Xu, H; Li, S; Irvin, M R; Zhi, D; Tiwari, H K; Absher, D M; Shuldiner, A R; Zhang, T; Chen, W; Tanner, K; Hong, C; Mitchell, B D; Berenson, G; Arnett, D K

    2017-03-01

    Adiponectin, an adipose-secreted protein that has been linked to insulin sensitivity, plasma lipids, and inflammatory patterns, is an established biomarker for metabolic health. Despite clinical relevance and high heritability, the determinants of plasma adiponectin levels remain poorly understood. We conducted the first epigenome-wide cross-sectional study of adiponectin levels using methylation data on 368,051 cytosine-phosphate-guanine (CpG) sites in CD4+ T-cells from the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN, n = 991). We fit linear mixed models, adjusting for age, sex, study site, T-cell purity, and family. We have identified a positive association (regression coefficient ± SE = 0.01 ± 0.001, P = 3.4 × 10(-13)) between plasma adiponectin levels and methylation of a CpG site in CPT1A, a key player in fatty acid metabolism. The association was replicated (n = 474, P = 0.0009) in whole blood samples from the Amish participants of the Heredity and Phenotype Intervention (HAPI) Heart Study as well as White (n = 592, P = 0.0005) but not Black (n = 243, P = 0.18) participants of the Bogalusa Heart Study (BHS). The association remained significant upon adjusting for BMI and smoking in GOLDN and HAPI but not BHS. We also identified associations between methylation loci in RNF145 and UFM1 and plasma adiponectin in GOLDN and White BHS participants, although the association was not robust to adjustment for BMI or smoking. We have identified and replicated associations between several biologically plausible loci and plasma adiponectin. These findings support the importance of epigenetic processes in metabolic traits, laying the groundwork for future translational applications. Copyright © 2016 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All

  7. A New Assumed Interaction. Experiments and Manifestations in Astrophysics

    CERN Document Server

    Baurov, Yu A

    2008-01-01

    Results of experimental investigations of a new assumed interaction in nature with the aid of high-current magnets, torsion and piezoresonance balances, high-precision gravimeter, fluctuations in intensity of betta-decay of radioactive elements, plasma devices and manifestations in astrophysics are presented. A possible explanation of the results obtained based on a hypothesis of global anisotropy of physical space caused by the existence of a cosmological vectorial potential A_g, is given. It is shown that the vector A_g has the following coordinates in the second equatorial coordinate system: right ascension alpha = 293 +- 10, declination delta = 36 +- 10.

  8. Statistical motor number estimation assuming a binomial distribution.

    Science.gov (United States)

    Blok, Joleen H; Visser, Gerhard H; de Graaf, Sándor; Zwarts, Machiel J; Stegeman, Dick F

    2005-02-01

    The statistical method of motor unit number estimation (MUNE) uses the natural stochastic variation in a muscle's compound response to electrical stimulation to obtain an estimate of the number of recruitable motor units. The current method assumes that this variation follows a Poisson distribution. We present an alternative that instead assumes a binomial distribution. Results of computer simulations and of a pilot study on 19 healthy subjects showed that the binomial MUNE values are considerably higher than those of the Poisson method, and in better agreement with the results of other MUNE techniques. In addition, simulation results predict that the performance in patients with severe motor unit loss will be better for the binomial than Poisson method. The adapted method remains closer to physiology, because it can accommodate the increase in activation probability that results from rising stimulus intensity. It does not need recording windows as used with the Poisson method, and is therefore less user-dependent and more objective and quicker in its operation. For these reasons, we believe that the proposed modifications may lead to significant improvements in the statistical MUNE technique.

  9. CPT-based probabilistic and deterministic assessment of in situ seismic soil liquefaction potential

    Science.gov (United States)

    Moss, R.E.S.; Seed, R.B.; Kayen, R.E.; Stewart, J.P.; Der Kiureghian, A.; Cetin, K.O.

    2006-01-01

    This paper presents a complete methodology for both probabilistic and deterministic assessment of seismic soil liquefaction triggering potential based on the cone penetration test (CPT). A comprehensive worldwide set of CPT-based liquefaction field case histories were compiled and back analyzed, and the data then used to develop probabilistic triggering correlations. Issues investigated in this study include improved normalization of CPT resistance measurements for the influence of effective overburden stress, and adjustment to CPT tip resistance for the potential influence of "thin" liquefiable layers. The effects of soil type and soil character (i.e., "fines" adjustment) for the new correlations are based on a combination of CPT tip and sleeve resistance. To quantify probability for performancebased engineering applications, Bayesian "regression" methods were used, and the uncertainties of all variables comprising both the seismic demand and the liquefaction resistance were estimated and included in the analysis. The resulting correlations were developed using a Bayesian framework and are presented in both probabilistic and deterministic formats. The results are compared to previous probabilistic and deterministic correlations. ?? 2006 ASCE.

  10. Plasma expansion into vacuum assuming a steplike electron energy distribution.

    Science.gov (United States)

    Kiefer, Thomas; Schlegel, Theodor; Kaluza, Malte C

    2013-04-01

    The expansion of a semi-infinite plasma slab into vacuum is analyzed with a hydrodynamic model implying a steplike electron energy distribution function. Analytic expressions for the maximum ion energy and the related ion distribution function are derived and compared with one-dimensional numerical simulations. The choice of the specific non-Maxwellian initial electron energy distribution automatically ensures the conservation of the total energy of the system. The estimated ion energies may differ by an order of magnitude from the values obtained with an adiabatic expansion model supposing a Maxwellian electron distribution. Furthermore, good agreement with data from experiments using laser pulses of ultrashort durations τ(L)Maxwellian electron distribution is assumed.

  11. Examining roles pharmacists assume in disasters: a content analytic approach.

    Science.gov (United States)

    Ford, Heath; Dallas, Cham E; Harris, Curt

    2013-12-01

    Numerous practice reports recommend roles pharmacists may adopt during disasters. This study examines the peer-reviewed literature for factors that explain the roles pharmacists assume in disasters and the differences in roles and disasters when stratified by time. Quantitative content analysis was used to gather data consisting of words and phrases from peer-reviewed pharmacy literature regarding pharmacists' roles in disasters. Negative binomial regression and Kruskal-Wallis nonparametric models were applied to the data. Pharmacists' roles in disasters have not changed significantly since the 1960s. Pharmaceutical supply remains their preferred role, while patient management and response integration roles decrease in context of common, geographically widespread disasters. Policy coordination roles, however, significantly increase in nuclear terrorism planning. Pharmacists' adoption of nonpharmaceutical supply roles may represent a problem of accepting a paradigm shift in nontraditional roles. Possible shortages of personnel in future disasters may change the pharmacists' approach to disaster management.

  12. ELEMENTS OF CONTROL OVER HIERARCHIE SYSTEMS WITH ASSUMED HIERARCHY

    Directory of Open Access Journals (Sweden)

    Kushnir N. V.

    2015-05-01

    Full Text Available The article presents a mathematical model of control over dynamic hierarchy system. The model was proposed for dealing with systems with assumed order in the technical problem of predicting destructions depending onto the amount of defects on different scale levels. The problem of the closest to a certain point of shelf life of hierarchy system is solved. The example of approach control during the given time is given. The problem concerns mathematic programming. Formulation of multi-parameter vector optimization criteria (improvement with its own hierarchy and the formal exercise of multi-criteria optimization of the model parameters. The research can achieve clarity about the conditions under which the structure is preserved. Managing sustainable development system with a given level of the hierarchy for the technical systems can only be achieved in keeping

  13. Beyond an assumed mother–child symbiosis in nutritional guidelines

    DEFF Research Database (Denmark)

    Nielsen, Annemette; Michaelsen, Kim F.; Holm, Lotte

    2014-01-01

    of the child and the interest and focus of the mother. The aim of this qualitative study was to explore mothers’ concerns and feeding practices in the context of everyday life. A total of 45 mothers with children either seven months old or 13 months old participated. The results showed that the need to find......Researchers question the implications of the way in which “motherhood” is constructed in public health discourse. Current nutritional guidelines for Danish parents of young children are part of this discourse. They are shaped by an assumed symbiotic relationship between the nutritional needs...... practical solutions for the whole family in a busy everyday life, to socialise the child into the family and society at large, and to create personal relief from the strain small children put on time and energy all served as socially acceptable reasons for knowingly departing from nutritional...

  14. Tracing of the 1st IEC Secretariat Assumed by China

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    @@ Introduction The IEC central office informed in 7/543/AC that the secretariat of TC 7 would be taken over by the Chinese National Committee on January 10, 2003 and affirmed subsequently in 7/544/AC that the secretariat of TC 7 has been taken over by the Chinese National Committee which appointing secretary in Shanghai Electric Cable Research Institute as no objection has been raised by the Standardization Management Board members. It's the first IEC secretariat that assumed by China, with great significance, just as commented by the media that the commitment indicate undoubtedly China is to play a much more active and important role in the world especially after its entry into world trade organization as well as the trend of global economic integration.

  15. Gauge invariant electromagnetic properties of fermions induced by CPT violation in the Standard Model Extension

    CERN Document Server

    Moyotl, A; Toscano, J J; Tututi, E S

    2013-01-01

    Low-energy Lorentz-invariant quantities could receive contributions from a fundamental theory producing small Lorentz-violating effects. Within the Lorentz-violating extension of quantum electrodynamics, we investigate, perturbatively, the contributions to the one-loop ffgamma vertex from the CPT-violating axial coupling of a vector background field to fermions. We find that the resulting vertex function has a larger set of Lorentz structures than the one characterizing the usual, Lorentz invariant, parametrization of the ffgamma vertex. We prove gauge invariance of the resulting one-loop expression through a set of gauge invariant nonrenormalizable operators introducing new-physics effects at the first and second orders in Lorentz violation, and which generate tree-level contributions to the ffgamma vertex. Whereas loop contributions involving parameters that violate Lorentz invariance at the first order are CPT-odd, those arising at the second order are CPT-even, so that contributions to low-energy physics ...

  16. Strict limit on CPT violation from polarization of γ-ray bursts.

    Science.gov (United States)

    Toma, Kenji; Mukohyama, Shinji; Yonetoku, Daisuke; Murakami, Toshio; Gunji, Shuichi; Mihara, Tatehiro; Morihara, Yoshiyuki; Sakashita, Tomonori; Takahashi, Takuya; Wakashima, Yudai; Yonemochi, Hajime; Toukairin, Noriyuki

    2012-12-14

    We report the strictest observational verification of CPT invariance in the photon sector, as a result of γ-ray polarization measurement of distant gamma-ray bursts (GRBs), which are the brightest stellar-sized explosions in the Universe. We detected γ-ray polarization of three GRBs with high significance levels, and the source distances may be constrained by a well-known luminosity indicator for GRBs. For the Lorentz- and CPT-violating dispersion relation E(±)(2) = p(2) ± 2ξp(3)/M(Pl), where ± denotes different circular polarization states of the photon, the parameter ξ is constrained as |ξ|violating effect leads to the expectation that quantum gravity presumably respects the CPT invariance.

  17. Models and (some) Searches for CPT Violation: From Early Universe to the Present Era

    Science.gov (United States)

    Mavromatos, Nick E.

    2017-07-01

    In the talk, I review theoretical models, inspired by quantum gravity, that may violate CPT symmetry. The amount of violation today (which is constrained severely by a plethora of experiments that I will not describe due to lack of space) need not be the same with the one that occurred in the Early Universe,. In certain models, one can obtain a precise temperature dependence of CPT violating effects, which is such that these effects are significant during the radiation era of the Universe, but are damped quickly so that they do not to affect nucleosynthesis and are negligible in the present epoch (that is, beyond experimental detection with the current experimental sensitivity). The CPT Violation (CPTV) in these models may arise from special properties of the background over which the fields of the model are propagating upon and be responsible for the generation of a matter-antimatter asymmetry, where any CP violation effects could only assist in the creation of the asymmetry, the dominant effect being CPTV. However, there are cases, where the CPTV arises as a consequence of an ill-defined CPT operator due to decoherence as a result of quantum gravity environmental degrees of freedom, inaccessible to a low-energy observer. I also discuss briefly the current-era phenomenology of some of the above models; in particular, for the ones involving decoherence-induced CPT violation, I argue that entangled states of neutral mesons (Kaons or B-systems) can provide smoking-gun sensitive tests or even falsify some of these models. If CPT is ill-defined one may also encounter violations of the spin-statistics theorem, with possible consequences for the Pauli Exclusion Principle.

  18. Assumed Probability Density Functions for Shallow and Deep Convection

    Directory of Open Access Journals (Sweden)

    Steven K Krueger

    2010-10-01

    Full Text Available The assumed joint probability density function (PDF between vertical velocity and conserved temperature and total water scalars has been suggested to be a relatively computationally inexpensive and unified subgrid-scale (SGS parameterization for boundary layer clouds and turbulent moments. This paper analyzes the performance of five families of PDFs using large-eddy simulations of deep convection, shallow convection, and a transition from stratocumulus to trade wind cumulus. Three of the PDF families are based on the double Gaussian form and the remaining two are the single Gaussian and a Double Delta Function (analogous to a mass flux model. The assumed PDF method is tested for grid sizes as small as 0.4 km to as large as 204.8 km. In addition, studies are performed for PDF sensitivity to errors in the input moments and for how well the PDFs diagnose some higher-order moments. In general, the double Gaussian PDFs more accurately represent SGS cloud structure and turbulence moments in the boundary layer compared to the single Gaussian and Double Delta Function PDFs for the range of grid sizes tested. This is especially true for small SGS cloud fractions. While the most complex PDF, Lewellen-Yoh, better represents shallow convective cloud properties (cloud fraction and liquid water mixing ratio compared to the less complex Analytic Double Gaussian 1 PDF, there appears to be no advantage in implementing Lewellen-Yoh for deep convection. However, the Analytic Double Gaussian 1 PDF better represents the liquid water flux, is less sensitive to errors in the input moments, and diagnoses higher order moments more accurately. Between the Lewellen-Yoh and Analytic Double Gaussian 1 PDFs, it appears that neither family is distinctly better at representing cloudy layers. However, due to the reduced computational cost and fairly robust results, it appears that the Analytic Double Gaussian 1 PDF could be an ideal family for SGS cloud and turbulence

  19. Search for Lorentz invariance and CPT violation with the MINOS far detector.

    Science.gov (United States)

    Adamson, P; Auty, D J; Ayres, D S; Backhouse, C; Barr, G; Barrett, W L; Bishai, M; Blake, A; Bock, G J; Boehnlein, D J; Bogert, D; Bower, C; Budd, S; Cavanaugh, S; Cherdack, D; Childress, S; Choudhary, B C; Coelho, J A B; Cobb, J H; Coleman, S J; Corwin, L; Cravens, J P; Cronin-Hennessy, D; Danko, I Z; de Jong, J K; Devenish, N E; Diwan, M V; Dorman, M; Escobar, C O; Evans, J J; Falk, E; Feldman, G J; Frohne, M V; Gallagher, H R; Gomes, R A; Goodman, M C; Gouffon, P; Gran, R; Grant, N; Grzelak, K; Habig, A; Harris, D; Harris, P G; Hartnell, J; Hatcher, R; Himmel, A; Holin, A; Huang, X; Hylen, J; Ilic, J; Irwin, G M; Isvan, Z; Jaffe, D E; James, C; Jensen, D; Kafka, T; Kasahara, S M S; Koizumi, G; Kopp, S; Kordosky, M; Krahn, Z; Kreymer, A; Lang, K; Lefeuvre, G; Ling, J; Litchfield, P J; Loiacono, L; Lucas, P; Mann, W A; Marshak, M L; Mayer, N; McGowan, A M; Mehdiyev, R; Meier, J R; Messier, M D; Michael, D G; Miller, J L; Miller, W H; Mishra, S R; Mitchell, J; Moore, C D; Mualem, L; Mufson, S; Musser, J; Naples, D; Nelson, J K; Newman, H B; Nichol, R J; Oliver, W P; Orchanian, M; Paley, J; Patterson, R B; Patzak, T; Pawloski, G; Pearce, G F; Pittam, R; Plunkett, R K; Ratchford, J; Raufer, T M; Rebel, B; Rodrigues, P A; Rosenfeld, C; Rubin, H A; Ryabov, V A; Sanchez, M C; Saoulidou, N; Schneps, J; Schreiner, P; Semenov, V K; Shanahan, P; Smart, W; Sousa, A; Strait, M; Tagg, N; Talaga, R L; Thomas, J; Thomson, M A; Tinti, G; Toner, R; Tzanakos, G; Urheim, J; Vahle, P; Viren, B; Weber, A; Webb, R C; White, C; Whitehead, L; Wojcicki, S G; Wright, D M; Yang, T; Zois, M; Zwaska, R

    2010-10-08

    We searched for a sidereal modulation in the MINOS far detector neutrino rate. Such a signal would be a consequence of Lorentz and CPT violation as described by the standard-model extension framework. It also would be the first detection of a perturbative effect to conventional neutrino mass oscillations. We found no evidence for this sidereal signature, and the upper limits placed on the magnitudes of the Lorentz and CPT violating coefficients describing the theory are an improvement by factors of 20-510 over the current best limits found by using the MINOS near detector.

  20. A CPT-even Lorentz-violating nonminimal coupling between fermions and photons

    CERN Document Server

    Casana, R; Santos, E Passos F E P Dos; Silva, E O

    2013-01-01

    We propose a CPT-even and Lorentz-violating dimension-five nonminimal coupling between fermionic and gauge fields, involving the CPT-even and Lorentz-violating gauge tensor of the Standard-Model Extension. This nonminimal coupling modifies the nonrelativistic regime of Dirac particles, inducing new effects such as an electric-Zeeman-like spectrum splitting and an anomalous-like contribution to the electron magnetic moment. These new effects allow to constrain the magnitude of this nonminimal coupling in 1 part in $10^{16}.$

  1. a Cpt-Even Lorentz-Violating Nonminimal Coupling Between Fermions and Photons

    Science.gov (United States)

    Casana, R.; Ferreira, M. M.; Dos Santos, F. E. P.; Silva, E. O.; Passos, E.

    2014-01-01

    We propose a CPT-even and Lorentz-violating dimension-five nonminimal coupling between fermionic and gauge fields, involving the CPT-even and Lorentz-violating gauge tensor of the Standard-Model Extension. This nonminimal coupling modifies the nonrelativistic regime of Dirac particles, inducing new effects such as an electric-Zeeman-like spectrum splitting and an anomalous-like contribution to the electron magnetic moment. These new effects allow to constrain the magnitude of this nonminimal coupling in 1 part in 1016.

  2. New CPT-even and Lorentz-violating nonminimal coupling in the Dirac equation

    Science.gov (United States)

    Casana, R.; Ferreira, M. M., Jr.; Passos, E.; dos Santos, F. E. P.; Silva, E. O.

    2013-02-01

    In this work, we propose a CPT-even and Lorentz-violating dimension-five nonminimal coupling between fermionic and gauge fields, involving the CPT-even and Lorentz-violating gauge tensor of the Standard Model extension. This nonminimal coupling modifies the Dirac equation, whose nonrelativistic regime is governed by a Hamiltonian which induces new effects, such as an electric-Zeeman-like spectrum splitting and an anomalouslike contribution to the electron magnetic moment, among others. Some of these new effects allow one to constrain the magnitude of this nonminimal coupling in 1 part in 1016(eV)-1.

  3. Sensitivity of continuous performance test (CPT) at age 14years to developmental methylmercury exposure

    DEFF Research Database (Denmark)

    Julvez, Jordi; Debes, Frodi; Weihe, Pal

    2010-01-01

    different time intervals after test initiation. A total of 878 adolescents (87% of birth cohort members) completed the CPT. The RT latencies were recorded for 10min, with visual targets presented at 1000ms intervals. After confounder adjustment, regression coefficients showed that CPT-RT outcomes differed...... in their associations with exposure biomarkers of prenatal methylmercury exposure: During the first 2min, the average HRT was weakly associated with methylmercury (beta (SE) for a ten-fold increase in exposure, (3.41 (2.06)), was strongly for the 3-to-6min interval (6.10 (2.18)), and the strongest during 7-10min after...

  4. Testing CPT and Lorentz Invariance with the Anomalous Spin Precession of the Muon

    CERN Document Server

    Deile, M

    2001-01-01

    This article discusses tests of CPT and Lorentz invariance with data from the muon g-2 experiment at Brookhaven National Laboratory. According to an extension of the Standard Model by Kostelecky et al., CPT/Lorentz violating terms in the Lagrangian induce a shift of the anomaly frequency omega_a of muons in a magnetic field. This shift is predicted to be different for positive and negative muons and to oscillate with the Earth's sidereal frequency. We discuss the sensitivity of the g-2 experiment to different parameters of this Standard Model extension and propose an analysis method to search for sidereal variations of omega_a.

  5. Lorentz Invariant CPT Violating Effects for a Class of Gauge-invariant Nonlocal Thirring Models

    CERN Document Server

    Patra, Pinaki

    2013-01-01

    CPT violation and Lorentz invariance can coexist in the framework of non-local field theory. Local gauge-invariance may not hold for the few non-local interaction terms. However, the gauge-invariance for the non-local interaction term can be formulated by the inclusion of Swinger non-integrable phase factor. In this article we have proposed a class of CPT violating Lorentz invariant Nonlocal Gauge-invariant models which can be termed as non-local gauge-invariant Thirring models. The inclusion of non-locality will modify the current conservation laws. Also, the possible particle antiparticle mass-splitting in this respect is discussed.

  6. Testing violation of CPT and quantum mechanics in the K(0) - bar-K(0) system

    Science.gov (United States)

    Huet, P.

    1994-05-01

    I report a recent study made in collaboration with M.E. Peskin, on the time dependence of a kaon beam propagating according to a generalization of quantum mechanics due to Ellis, Hagelin, Nanopoulos and Srednicki, in which CP- and CPT-violating signatures arise from the evolution of pure states to mixed states. Constraints on the magnitude of its parameters are established on the basis of existing experimental data. New facilities such as phi factories are shown to be particularly adequate to study this generalization from quantum mechanics and to disentangle its parameters from other CPT violating perturbations of the kaon system.

  7. A Search for Lorentz Invariance and CPT Violation with the MINOS Far Detector

    CERN Document Server

    Adamson, P; Ayres, D S; Backhouse, C; Barr, G; Barrett, W L; Bishai, M; Blake, A; Bock, G J; Boehnlein, D J; Bogert, D; Bower, C; Budd, S; Cavanaugh, S; Cherdack, D; Childress, S; Choudhary, B C; Coelho, J A B; Cobb, J H; Coleman, S J; Corwin, L; Cravens, J P; Cronin-Hennessy, D; Danko, I Z; de Jong, J K; Devenish, N E; Diwan, M V; Dorman, M; Escobar, C O; Evans, J J; Falk, E; Feldman, G J; Frohne, M V; Gallagher, H R; Gomes, R A; Goodman, M C; Gouffon, P; Gran, R; Grant, N; Grzelak, K; Habig, A; Harris, D; Harris, P G; Hartnell, J; Hatcher, R; Himmel, A; Holin, A; Huang, X; Hylen, J; Ilic, J; Irwin, G M; Isvan, Z; Jaffe, D E; James, C; Jensen, D; Kafka, T; Kasahara, S M S; Koizumi, G; Kopp, S; Kordosky, M; Krahn, Z; Kreymer, A; Lang, K; Lefeuvre, G; Ling, J; Litchfield, P J; Loiacono, L; Lucas, P; Mann, W A; Marshak, M L; Mayer, N; McGowan, A M; Mehdiyev, R; Meier, J R; Messier, M D; Michael, D G; Miller, J L; Miller, W H; Mishra, S R; Mitchell, J; Moore, C D; Mualem, L; Mufson, S; Musser, J; Naples, D; Nelson, J K; Newman, H B; Nichol, R J; Oliver, W P; Orchanian, M; Paley, J; Patterson, R B; Patzak, T; Pawloski, G; Pearce, G F; Pittam, R; Plunkett, R K; Ratchford, J; Raufer, T M; Rebel, B; Rodrigues, P A; Rosenfeld, C; Rubin, H A; Ryabov, V A; Sanchez, M C; Saoulidou, N; Schneps, J; Schreiner, P; Semenov, V K; Shanahan, P; Smart, W; Sousa, A; Strait, M; Tagg, N; Talaga, R L; Thomas, J; Thomson, M A; Tinti, G; Toner, R; Tzanakos, G; Urheim, J; Vahle, P; Viren, B; Weber, A; Webb, R C; White, C; Whitehead, L; Wojcicki, S G; Wright, D M; Yang, T; Zois, M; Zwaska, R

    2010-01-01

    We searched for a sidereal modulation in the MINOS far detector neutrino rate. Such a signal would be a consequence of Lorentz and CPT violation as described by the Standard-Model Extension framework. It also would be the first detection of a perturbative effect to conventional neutrino mass oscillations. We found no evidence for this sidereal signature and the upper limits placed on the magnitudes of the Lorentz and CPT violating coefficients describing the theory are an improvement by factors of $20-510$ over the current best limits found using the MINOS near detector.

  8. Schr\\"odinger-Pauli Equation for the Standard Model Extension CPT-Violating Dirac Equation

    CERN Document Server

    Gutierrez, Thomas D

    2015-01-01

    It is instructive to investigate the non-relativistic limit of the simplest Standard Model Extension (SME) CPT-violating Dirac-like equation but with minimal coupling to the electromagnetic fields. In this limit, it becomes an intuitive Schr\\"odinger-Pauli-like equation. This is comparable to the free particle treatment as explored by Kostelecky and Lane, but this exercise only considers the $a$ and $b$ CPT-violating terms and $\\vec{p}/m$ terms to first order. Several toy systems are discussed.

  9. Search for CPT and Lorentz-Symmetry Violation in Entangled Neutral Kaons

    CERN Document Server

    Di Domenico, Antonio

    2016-01-01

    The neutral-kaon system constitutes a fantastic and unique laboratory for the study of CPT symmetry and the basic principles of quantum mechanics, and a $\\phi$-factory represents a unique opportunity to push forward these studies. The experimental results show no deviation from the expectations of quantum mechanics and CPT symmetry, while the extreme precision of the measure- ments, in some cases, reaches the interesting Planck-scale region. At present the KLOE-2 experiment is collecting data with an upgraded detector with the aim of significantly improving these kinds of experimental tests.

  10. On one-loop corrections in the CPT-even extension of QED

    CERN Document Server

    Belich, H; Nascimento, J R; Petrov, A Yu

    2016-01-01

    In this paper, we describe the generation of the CPT-even, aether-like terms via the new CPT-even magnetic-like coupling. We have carried out a study the loop corrections generated by this coupling. Previous investigations has been initiated on this issue and we have extended, first promoting the study to five dimensions where the theory is one-loop finite, second, in studying of higher-point functions, third, in studying of quantum corrections to vertices of the interaction.

  11. Method for Predicting Void Ratio and Triaxial Friction Angle from Laboratory CPT at Shallow Depths

    DEFF Research Database (Denmark)

    Larsen, Kim André; Ibsen, Lars Bo

    In this report an investigation of the relationship between the tip resistance, qc of a laboratory CPT-probe versus the relative density, Dr and friction angle, ∏ of Aalborg University Sand No. 0 is carried out. A method for estimating the relative density and the triaxial friction angle from...... the cone resistance of the laboratory probe is proposed. The suggested method deals with the fact that the friction angle is depended of the stress level especially at low stresses. The method includes a calibration of the cone resistance from the laboratory CPT at shallow depths i.e. low values of d...

  12. General CPT-even dimension-five nonminimal couplings between fermions and photons yielding EDM and MDM

    CERN Document Server

    Araujo, Jonas B; Ferreira, Manoel M

    2016-01-01

    In this letter, we examine general CPT-even nonminimal interactions, between fermions and photons, that yield electric dipole moment (EDM) and magnetic dipole moment (MDM) in the context of the Dirac equation. The couplings are dimension-five CPT-even and Lorentz-violating nonminimal structures, composed of a rank-2 tensor, $T_{\\mu\

  13. Maps and documentation of seismic CPT soundings in the central, eastern, and western United States

    Science.gov (United States)

    Holzer, Thomas L.; Noce, Thomas E.; Bennett, Michael J.

    2010-01-01

    Nine hundred twenty seven seismic cone penetration tests (CPT) in a variety of geologic deposits and geographic locations were conducted by the U.S. Geological Survey (USGS) primarily between 1998 and 2008 for the purpose of collecting penetration test data to evaluate the liquefaction potential of different types of surficial geologic deposits (table 1). The evaluation is described in Holzer and others (in press). This open-file report summarizes the seismic CPT and geotechnical data that were collected for the evaluation, outlines the general conditions under which the data were acquired, and briefly describes the geographic location of each study area and local geologic conditions. This report also describes the field methods used to obtain the seismic CPT data and summarizes the results of shear-wave velocities measurements at 2-m intervals in each sounding. Although the average depth of the 927 soundings was 18.5 m, we estimated a time-averaged shear-wave velocity to depths of 20 m and 30 m, VS20 and VS30, respectively, for soundings deeper than 10 m and 20 m. Soil sampling also was selectively conducted in many of the study areas at representative seismic CPT soundings. These data are described and laboratory analyses of geotechnical properties of these samples are summarized in table 2.

  14. Parity-odd and CPT-even electrodynamics of the SME at Finite Temperature

    CERN Document Server

    Casana, Rodolfo; Silva, Madson R O

    2009-01-01

    This work examines the finite temperature properties of the CPT-even and parity-odd electrodynamics of the standard model extension. We start from the partition function written into the functional integral formalism in Ref. \\cite{Finite}. After specializing the Lorentz-violating tensor $ W_{\\alpha \

  15. Crystal Structure of the Geobacillus stearothermophilus Carboxylesterase Est55 and Its Activation of Prodrug CPT-11

    Science.gov (United States)

    Liu, Ping; Ewis, Hosam E.; Tai, Phang C.; Lu, Chung-Dar; Weber, Irene T.

    2007-01-01

    Several mammalian carboxylesterases were shown to activate the prodrug irinotecan (CPT-11) to produce SN-38, a topoisomerase inhibitor used in cancer therapy. However, the potential use of bacterial carboxylesterases, which have the advantage of high stability, has not been explored. We present the crystal structure of the carboxyesterase Est55 from Geobacillus stearothermophilus and evaluation of its enzyme activity on CPT-11. Crystal structures were determined at pH 6.2 and 6.8 and resolution of 2.0 and 1.58 Å, respectively. Est55 folds into three domains, a catalytic domain, an α/β domain and a regulatory domain. The structure is in an inactive form; the side chain of His409, one of the catalytic triad residues, is directed away from the other catalytic residues Ser194 and Glu310. Moreover, the adjacent Cys408 is triply oxidized and lies in the oxyanion hole, which would block the binding of substrate, suggesting a regulatory role. However, Cys408 is not essential for enzyme activity. Mutation of Cys408 showed that hydrophobic side chains were favorable, while polar serine was unfavorable for enzyme activity. Est55 was shown to hydrolyze CPT-11 into the active form SN-38. The mutant C408V provided a more stable enzyme for activation of CPT-11. Therefore, engineered thermostable Est55 is a candidate for use with irinotecan in enzyme-prodrug cancer therapy. PMID:17239398

  16. Augmenting CPT to Improve Sleep Impairment in PTSD: A Randomized Clinical Trial

    Science.gov (United States)

    Galovski, Tara E.; Mott, Juliette; Blain, Leah M.; Elwood, Lisa; Gloth, Chelsea; Fletcher, Thomas

    2015-01-01

    Objective Despite the success of empirically supported treatments for posttraumatic stress disorder (PTSD), sleep impairment frequently remains refractory following treatment for PTSD. This single-site, randomized controlled trial examined the effectiveness of sleep-directed hypnosis as a complement to an empirically supported psychotherapy for PTSD (cognitive processing therapy; CPT). Method Participants completed either 3 weeks of hypnosis (n = 52) or a symptom monitoring control condition (n = 56) before beginning standard CPT. Multilevel modeling was used to investigate differential patterns of change to determine whether hypnosis resulted in improvements in sleep, PTSD, and depression. An intervening variable approach was then used to determine whether improvements in sleep achieved during hypnosis augmented change in PTSD and depression during CPT. Results After the initial phase of treatment (hypnosis or symptom monitoring), the hypnosis condition showed significantly greater improvement than the control condition in sleep and depression, but not PTSD. After CPT, both conditions demonstrated significant improvement in sleep and PTSD; however, the hypnosis condition demonstrated greater improvement in depressive symptoms. As sleep improved, there were corresponding improvements in PTSD and depression, with a stronger relationship between sleep and PTSD. Conclusion Hypnosis was effective in improving sleep impairment, but those improvements did not augment gains in PTSD recovery during the trauma-focused intervention. Public Health Significance: This study suggests that hypnosis may be a viable treatment option in a stepped-care approach for treating sleep impairment in individuals suffering from PTSD. PMID:26689303

  17. A general review of the role of irinotecan (CPT11) in the treatment of gastric cancer.

    Science.gov (United States)

    Farhat, Fadi Sami

    2007-01-01

    The prognosis of gastric tumor is generally poor because most tumors are diagnosed at an advanced stage. Chemotherapy has a proven palliative role in advanced gastric cancer and several combination regimens were explored in the last 10 yr. Nevertheless, none of them showed a convincing improvement resulting in an enhancement of response rate and overall survival without discrimination of the quality of life. Irinotecan (CPT11) has been evaluated in multiple trials alone or in combined therapy with promising results and good tolerance. Thus, a review of the importance and impact of CPT11 in this indication is detailed. This article reviews the evidence for the use of CPT11 in the treatment of gastric cancer based on a computerized MEDLINE search of literature published until August 2006 leading to a total of 91 publications. CPT11 was frequently used and showed a good response rate varying from 14% to 23% as single agent and 45% to 70% in combination with a median time to progression of 3 mo in single agent and 4-6 mo in combination, and median overall survival of approx 7 mo in single agent and up to 10.58 mo in combination. The overall response of irinotecan-based chemotherapy in advanced gastric cancer was shown to be as effective as other combined chemotherapy. The hematological and digestive toxicity were tolerable and mild, especially in weekly regimen. Thus, irinotecan-based chemotherapy should be considered as one of the preferred choices in front line chemotherapy in advanced gastric cancer.

  18. $K_S$ semileptonic decays and test of $\\mathcal{CPT}$ symmetry with the KLOE detector

    CERN Document Server

    Kamińska, D

    2015-01-01

    Study of semileptonic decays of neutral kaons allows to perform a test of discrete symmetries, as well as basic principles of the Standard Model. In this paper a general review on dependency between charge asymmetry constructed for semileptonic decays of short- and long-lived kaons and $\\mathcal{CPT}$ symmetry is given.

  19. Symmetry violating kaon decays. [Muon number violation, review, T, and CPT invariance

    Energy Technology Data Exchange (ETDEWEB)

    Herczeg, P.

    1979-01-01

    An analysis of the muon number violating decay modes of the K-mesons is given. Subsequently, some new developments in the field of CP-violation are reviewed and the question of time-reversal invariance and the status of CPT-invariance are briefly considered. 42 references.

  20. A CPT-even and Lorentz-Violating nonminimal coupling in the Dirac equation

    Energy Technology Data Exchange (ETDEWEB)

    Ferreira Junior, Manoel; Casana, M.R.; Santos, Frederico E.P. dos; Silva, E.O. [UFMA, Sao Luis (Brazil); Passos, E. [UFCG, Campina Grande, PB (Brazil)

    2013-07-01

    Full text: The Standard Model Extension (SME) has been the usual framework for investigating signals of Lorentz violation in physical systems. It is the natural framework for studying properties of physical systems with Lorentz-violation since it includes Lorentz-violating terms in all sectors of the minimal standard model. The Lorentz-violating (LV) terms are generated as vacuum expectation values of tensors defined in a high energy scale. This framework has inspired a great deal of investigation in recent years. Such works encompass several distinct aspects involving fermion systems and radiative corrections, CPT- probing experiments, the electromagnetic CPT- and Lorentz-odd term, the 19 electromagnetic CPT-even coefficients. Recently, some studies involving higher dimensional operators have also been reported with great interest, including nonminimal interactions. These many contributions have elucidated the effects induced by Lorentz violation and served to set up stringent upper bounds on the LV coefficients. In the present work, we propose a new CPT-even, dimension-five, nonminimal coupling linking the fermionic and gauge fields in the context of the Dirac equation, involving the CPT-even tensor of the gauge term of the SME. By considering the nonrelativistic limit of the modified Dirac equation, we explicitly evaluate the new contributions to the nonrelativistic Hamiltonian. These new terms imply a direct correction on the anomalous magnetic moment, a kind of electrical Zeeman-like effect on the atomic spectrum, and a Rashba-like coupling term. These effects are then used to impose upper bounds on the magnitude of the non minimally coupled LV coefficients at the level of 1 part in 10{sub 16}. (author)

  1. 茂金属催化剂Cpt2MCl2(Cpt=tBuC5H4,M=Ti、zr、Hf)聚合丁烯-1的研究%Polymerization of Butene-1 Catalyzed byCpt2MCl2[Cpt=tBuC5H4,M=Ti(Ⅰ),Zr(Ⅱ),Hf(Ⅲ)

    Institute of Scientific and Technical Information of China (English)

    周光远; 程延祥; 金国新

    2001-01-01

    The synthesis and characterization of metallocene complexes Cpt2MC12[Cpt=tBuC5H4,M=Ti(Ⅰ), Zr(Ⅱ), Hr(Ⅲ)] are presented in catalyzation polymerization of butene-1. The metallocenecatalysts and polybutenes have been characterized by IR, 1H NMR and EI-MS spectra and DSCmeasurements. The catalytic features for butene-1 polymerization were studied under differentconditions. The results showed that Cpt2MCl2/MAO had high activity for butene-1 polymerization,improving the tacticity and molecular weight of the polymers obtained.%探讨了茂金属催化剂Cpt2MCl2(CPt=tBuC5H4,M=Ti,zr,Hf)的合成以及用于聚合丁烯-1的研究,研究了几种不同的茂金属催化剂和不同聚合条件下的催化行为,并通过IR、1H NMR、EI-MS、DSC、粘度法测分子量和正庚烷抽提等测试手段对催化剂和聚合物进行了表征.结果表明,叔丁基取代的茂金属催化剂催化丁烯-1聚合具有较高的催化活性,叔丁基的引入提高了聚合物的等规度和分子量.

  2. Phase II study of neoadjuvant 5-FU + leucovorin + CPT-11 in patients with resectable liver metastases from colorectal adenocarcinoma

    Directory of Open Access Journals (Sweden)

    Bigam David

    2004-07-01

    Full Text Available Abstract Background Following resection of liver metastases from colorectal cancer, 5-year survivals are reportedly 30 – 39%. It can be assumed that this clinical situation represents systemic disease. Therefore, it is postulated that systemic chemotherapy would improve outcomes, particularly in those whose disease is sensitive to the agents administered. One potential advantage of neoadjuvant chemotherapy is that it provides in vivo chemosensitivity data. Response to neoadjuvant chemotherapy could therefore guide adjuvant chemotherapy following resection of liver metastases from colorectal cancer. Methods and design This is a prospective Phase II evaluation of outcomes in patients with potentially resectable liver metastases. Patients will receive neoadjuvant chemotherapy and will undergo resection. Postoperative chemotherapy will be directed by the degree of response to preoperative chemotherapy. All patients with Stage IV colorectal adenocarcinoma isolated to the liver that have disease that is amenable to complete ablation by resection, radiofrequency ablation, and/or cryoablation will be candidates for the trial. Patients will receive CPT-11 180 mg/m2 IV (over 90 minutes on day 1 with 5-FU 400 mg/m2 bolus and 600 mg/m2 by 22 hour infusion and calcium folinate 200 mg/m2 on days 1 and 2, every 2 weeks. Altogether, six cycles of chemotherapy will be administered. Patients will then undergo resection and/or radiofrequency ablation. Patients who had stable disease or a clinical response with preoperative chemotherapy will receive an additional 12 cycles of CPT-11 180 mg/m2 IV (over 90 minutes on day 1 with 5-FU 400 mg/m2 bolus and 600 mg/m2 by 22 hour infusion and calcium folinate 200 mg/m2 on days 1 and 2 (given every 2 weeks. Patients with resectable disease who had progressive disease during neoadjuvant chemotherapy will receive best supportive care or an alternative agent, at the discretion of the treating physician. Those patients who are

  3. Liquefaction assessment based on combined use of CPT and shear wave velocity measurements

    Science.gov (United States)

    Bán, Zoltán; Mahler, András; Győri, Erzsébet

    2017-04-01

    Soil liquefaction is one of the most devastating secondary effects of earthquakes and can cause significant damage in built infrastructure. For this reason liquefaction hazard shall be considered in all regions where moderate-to-high seismic activity encounters with saturated, loose, granular soil deposits. Several approaches exist to take into account this hazard, from which the in-situ test based empirical methods are the most commonly used in practice. These methods are generally based on the results of CPT, SPT or shear wave velocity measurements. In more complex or high risk projects CPT and VS measurement are often performed at the same location commonly in the form of seismic CPT. Furthermore, VS profile determined by surface wave methods can also supplement the standard CPT measurement. However, combined use of both in-situ indices in one single empirical method is limited. For this reason, the goal of this research was to develop such an empirical method within the framework of simplified empirical procedures where the results of CPT and VS measurements are used in parallel and can supplement each other. The combination of two in-situ indices, a small strain property measurement with a large strain measurement, can reduce uncertainty of empirical methods. In the first step by careful reviewing of the already existing liquefaction case history databases, sites were selected where the records of both CPT and VS measurement are available. After implementing the necessary corrections on the gathered 98 case histories with respect to fines content, overburden pressure and magnitude, a logistic regression was performed to obtain the probability contours of liquefaction occurrence. Logistic regression is often used to explore the relationship between a binary response and a set of explanatory variables. The occurrence or absence of liquefaction can be considered as binary outcome and the equivalent clean sand value of normalized overburden corrected cone tip

  4. Search for Lorentz and CPT violation effects in Muon spin precession.

    Science.gov (United States)

    Bennett, G W; Bousquet, B; Brown, H N; Bunce, G; Carey, R M; Cushman, P; Danby, G T; Debevec, P T; Deile, M; Deng, H; Deninger, W; Dhawan, S K; Druzhinin, V P; Duong, L; Efstathiadis, E; Farley, F J M; Fedotovich, G V; Giron, S; Gray, F E; Grigoriev, D; Grosse-Perdekamp, M; Grossmann, A; Hare, M F; Hertzog, D W; Huang, X; Hughes, V W; Iwasaki, M; Jungmann, K; Kawall, D; Kawamura, M; Khazin, B I; Kindem, J; Krienen, F; Kronkvist, I; Lam, A; Larsen, R; Lee, Y Y; Logashenko, I; McNabb, R; Meng, W; Mi, J; Miller, J P; Mizumachi, Y; Morse, W M; Nikas, D; Onderwater, C J G; Orlov, Y; Ozben, C S; Paley, J M; Peng, Q; Polly, C C; Pretz, J; Prigl, R; zu Putlitz, G; Qian, T; Redin, S I; Rind, O; Roberts, B L; Ryskulov, N; Sedykh, S; Semertzidis, Y K; Shagin, P; Shatunov, Yu M; Sichtermann, E P; Solodov, E; Sossong, M; Steinmetz, A; Sulak, L R; Timmermans, C; Trofimov, A; Urner, D; von Walter, P; Warburton, D; Winn, D; Yamamoto, A; Zimmerman, D

    2008-03-07

    The spin precession frequency of muons stored in the (g-2) storage ring has been analyzed for evidence of Lorentz and CPT violation. Two Lorentz and CPT violation signatures were searched for a nonzero delta omega a(=omega a mu+ - omega a mu-) and a sidereal variation of omega a mu+/-). No significant effect is found, and the following limits on the standard-model extension parameters are obtained: bZ = -(1.0+/-1.1) x 10(-23) GeV; (m mu dZ0 + HXY)=(1.8+/-6.0) x 10(-23) GeV; and the 95% confidence level limits b perpendicular mu+ <1.4 x 10(-24) GeV and b perpendicular mu- <2.6 x 10(-24) GeV.

  5. Strong Equivalence, Lorentz and CPT Violation, Anti-Hydrogen Spectroscopy and Gamma-Ray Burst Polarimetry

    CERN Document Server

    Shore, G M

    2004-01-01

    The strong equivalence principle, local Lorentz invariance and CPT symmetry are fundamental ingredients of the quantum field theories used to describe elementary particle physics. Nevertheless, each may be violated by simple modifications to the dynamics while apparently preserving the essential fundamental structure of quantum field theory itself. In this paper, we analyse the construction of strong equivalence, Lorentz and CPT violating Lagrangians for QED and review and propose some experimental tests in the fields of astrophysical polarimetry and precision atomic spectroscopy. In particular, modifications of the Maxwell action predict a birefringent rotation of the direction of linearly polarised radiation from synchrotron emission which may be studied using radio galaxies or, potentially, gamma-ray bursts. In the Dirac sector, changes in atomic energy levels are predicted which may be probed in precision spectroscopy of hydrogen and anti-hydrogen atoms, notably in the Doppler-free, two-photon $1s-2s$ and...

  6. Gauge invariance and the Pauli-Villars regulator in Lorentz- and CPT-violating electrodynamics

    Science.gov (United States)

    Altschul, B.

    2004-11-01

    We examine the nonperturbative structure of the radiatively induced Chern-Simons term in a Lorentz- and CPT-violating modification of QED. Although the coefficient of the induced Chern-Simons term is in general undetermined, the nonperturbative theory appears to generate a definite value. However, the CPT-even radiative corrections in this same formulation of the theory generally break gauge invariance. We show that gauge invariance may yet be preserved through the use of a Pauli-Villars regulator, and, contrary to earlier expectations, this regulator does not necessarily give rise to a vanishing Chern-Simons term. Instead, two possible values of the Chern-Simons coefficient are allowed, one zero and one nonzero. This formulation of the theory therefore allows the coefficient to vanish naturally, in agreement with experimental observations.

  7. Testing violation of CPT and quantum mechanics in the K$_{0}\\overline{K}_{0}$ system

    CERN Document Server

    Huet, Patrick

    1994-01-01

    I report a recent study done in collaboration with M.E. Peskin, on the time dependence of a kaon beam propagating according to a generalization of quantum mechanics due to Ellis, Hagelin, Nanopoulos and Srednicki, in which CP- and CPT-violating signatures arise from the evolution of pure states to mixed states. Constraints on the magnitude of its parameters are established on the basis of existing experimental data. New facilities such as phi-factories are shown to be particularly adequate to study this generalization from \\qm\\ and to disentangle its parameters from other CPT violating perturbations of the kaon system. ( To appear in Proceedings of the First International Conference on Phenomenology of Unification from Present to Future, Roma, ITALY -- March 23-26, 1994.)

  8. Search for CPT and Lorentz Violation in B0-B0bar Oscillations with Dilepton Events

    Energy Technology Data Exchange (ETDEWEB)

    Collaboration, The BABAR; Aubert, B.

    2007-11-28

    We report results of a search for CPT and Lorentz violation in B{sup 0}-{bar B}{sup 0} oscillations using inclusive dilepton events from 232 million {Upsilon}(4S) {yields} B{bar B} decays recorded by the BABAR detector at the PEP-II B Factory at SLAC. We find 2.8{sigma} significance, compatible with no signal, for variations in the complex CPT violation parameter z at the Earth's sidereal frequency and extract values for the quantities {Delta}a{sub {mu}} in the general Lorentz-violating standard-model extension. The spectral powers for variations in z over the frequency range 0.26 year{sup -1} to 2.1 day{sup -1} are also compatible with no signal.

  9. Indirect Violation of CP, T and CPT in the Bd-system

    CERN Document Server

    Bañuls, M C

    2001-01-01

    The problem of indirect violation of discrete symmeties CP, T and CPT in a neutral meson system can be described using two complex parameters epsilon and delta, which are invariant under rephasing of meson and quark fields. For the Bd system, where the width difference between the physical states is negligible, only Re(delta) and Im(epsilon) survive. As a consequence, the traditional observables constructed for kaons, which are based on flavour tag, are not useful for the analogous study in this system. We describe how using a CP tag and studying CP-to-flavour transitions of the B mesons, we may build asymmetries, alternative to those used for the kaon, which enable us to test T and CPT invariances of the effective hamiltonian for the Bd system.

  10. Dimensional reduction of a Lorentz and CPT-violating Maxwell-Chern-Simons model

    Energy Technology Data Exchange (ETDEWEB)

    Belich, H. Jr.; Helayel Neto, J.A. [Centro Brasileiro de Pesquisas Fisicas (CBPF), Rio de Janeiro, RJ (Brazil). Coordenacao de Teoria de Campos e Particulas; Grupo de Fisica Teorica Jose Leite Lopes, Petropolis, RJ (Brazil); E-mails: belich@cbpf.br; helayel@cbpf.br; Ferreira, M.M. Jr. [Grupo de Fisica Teorica Jose Leite Lopes, Petropolis, RJ (Brazil); Maranhao Univ., Sao Luiz, MA (Brazil). Dept. de Fisica]. E-mail: manojr@cbpf.br; Orlando, M.T.D. [Grupo de Fisica Teorica Jose Leite Lopes, Petropolis, RJ (Brazil); Espirito Santo Univ., Vitoria, ES (Brazil). Dept. de Fisica e Quimica; E-mail: orlando@cce.ufes.br

    2003-01-01

    Taking as starting point a Lorentz and CPT non-invariant Chern-Simons-like model defined in 1+3 dimensions, we proceed realizing its dimensional to D = 1+2. One then obtains a new planar model, composed by the Maxwell-Chern-Simons (MCS) sector, a Klein-Gordon massless scalar field, and a coupling term that mixes the gauge field to the external vector, {nu}{sup {mu}}. In spite of breaking Lorentz invariance in the particle frame, this model may preserve the CPT symmetry for a single particular choice of {nu}{sup {mu}} . Analyzing the dispersion relations, one verifies that the reduced model exhibits stability, but the causality can be jeopardized by some modes. The unitary of the gauge sector is assured without any restriction , while the scalar sector is unitary only in the space-like case. (author)

  11. Resistance to irinotecan (CPT-11) activates epidermal growth factor receptor/nuclear factor kappa B and increases cellular metastasis and autophagy in LoVo colon cancer cells.

    Science.gov (United States)

    Chen, Ming-Cheng; Lee, Nien-Hung; Ho, Tsung-Jung; Hsu, Hsi-Hsien; Kuo, Chia-Hua; Kuo, Wei-Wen; Lin, Yueh-Min; Tsai, Fuu-Jen; Tsai, Chang-Hai; Huang, Chih-Yang

    2014-07-10

    Chemotherapy is usually applied to treat colon cancer but leads to chemoresistance, and increased metastasis and invasion. The main focus of this study is to observe effects of resistance to irinotecan (CPT-11) on metastasis, invasion and autophagy in CPT-11 resistant (CPT-11-R) LoVo colon cancer cells. CPT-11, a topoisomerase I inhibitor and a first-line chemotherapeutic drug, is used to treat colon cancer. CPT-11-R cells were constructed in a step-wise fashion with increasing CPT-11 doses. The CPT-11-R strain had a significantly lower expression of Wnt/β-catenin pathway, but induced an EGFR/IKKα/β/NF-κB pathway with elevated cell cycle, metastasis and basal autophagy.

  12. No Contact Terms for the Magnetic Field in Lorentz- and CPT-Violating Electrodynamics

    CERN Document Server

    Schober, Karl

    2016-01-01

    In a Lorentz- and CPT-violating modification of electrodynamics, the fields of a moving charge are known to have unusual singularities. This raises the question of whether the singular behavior may include $\\delta$-function contact terms, similar to those that appear in the fields of idealized dipoles. However, by calculating the magnetic field of an infinite straight wire in this theory, we demonstrate that there are no such contact terms in the magnetic field of a moving point charge

  13. Search for Violations of Lorentz Invariance and CPT Symmetry in B-(s)(0) Mixing

    NARCIS (Netherlands)

    Aaij, R.; Beteta, C. Abellan; Adeva, B.; Adinolfi, M.; Ajaltouni, Z.; Akar, S.; Albrecht, J.; Alessio, F.; Alexander, M.; Ali, S.; Alkhazov, G.; Cartelle, P. Alvarez; Alves, A. A.; Amato, S.; Amerio, S.; Amhis, Y.; An, L.; Anderlini, L.; Andreassi, G.; Andreotti, M.; Andrews, J. E.; Appleby, R. B.; Gutierrez, O. Aquines; Archilli, F.; d'Argent, P.; Artamonov, A.; Artuso, M.; Aslanides, E.; Auriemma, G.; Baalouch, M.; Bachmann, S.; Back, J. J.; Badalov, A.; Baesso, C.; Baker, S.; Baldini, W.; Barlow, R. J.; Barschel, C.; Barsuk, S.; Barter, W.; Batozskaya, V.; Battista, V.; Beaucourt, L.; Beddow, J.; Bedeschi, F.; Bediaga, I.; Bel, L. J.; Bellee, V.; Belloli, N.; Belyaev, I.; Ben-Haim, E.; Bencivenni, G.; Benson, S.; Benton, J.; Berezhnoy, A.; Bernet, R.; Bertolin, A.; Betti, F.; Bettler, M. -O.; van Beuzekom, M.; Bifani, S.; Billoir, P.; Bird, T.; Birnkraut, A.; Bizzeti, A.; Blake, T.; Blanc, F.; Blouw, J.; Blusk, S.; Bocci, V.; Bondar, A.; Bondar, N.; Bonivento, W.; Borgheresi, A.; Borghi, S.; Borisyak, M.; Borsato, M.; Boubdir, M.; Bowcock, T. J. V.; Bowen, E.; Bozzi, C.; Braun, S.; Britsch, M.; Britton, T.; Brodzicka, J.; Buchanan, E.; Burr, C.; Bursche, A.; Buytaert, J.; Cadeddu, S.; Calabrese, R.; Calvi, M.; Calvo Gomez, M.; Campana, P.; Perez, D. Campora; Capriotti, L.; Carbone, A.; Carboni, G.; Cardinale, R.; Cardini, A.; Carniti, P.; Carson, L.; Carvalho Akiba, K.; Casse, G.; Cassina, L.; Garcia, L. Castillo; Cattaneo, M.; Cauet, Ch.; Cavallero, G.; Cenci, R.; Charles, M.; Charpentier, Ph.; Chatzikonstantinidis, G.; Chefdeville, M.; Cheung, S. -F.; Chrzaszcz, M.; Vidal, X. Cid; Ciezarek, G.; Clarke, P. E. L.; Clemencic, M.; Cliff, H. V.; Closier, J.; Coco, V.; Cogan, J.; Cogneras, E.; Cogoni, V.; Cojocariu, L.; Collazuol, G.; Collins, P.; Comerma-Montells, A.; Contu, A.; Cook, A.; Coombes, M.; Coquereau, S.; Corti, G.; Corvo, M.; Couturier, B.; Cowan, G. A.; Craik, D. C.; Crocombe, A.; Torres, M. Cruz; Cunliffe, S.; Currie, R.; D'Ambrosio, C.; Dall'Occo, E.; Dalseno, J.; David, P. N. Y.; Davis, A.; De Aguiar Francisco, O.; De Bruyn, K.; De Capua, S.; De Cian, M.; De Miranda, J. M.; De Paula, L.; De Simone, P.; Dean, C. -T.; Decamp, D.; Deckenhoff, M.; Del Buono, L.; Deleage, N.; Demmer, M.; Derkach, D.; Deschamps, O.; Dettori, F.; Dey, B.; Di Canto, A.; Di Ruscio, F.; Dordei, F.; Dorigo, M.; Dosil Suarez, A.; Dovbnya, A.; Dreimanis, K.; Dufour, L.; Dujany, G.; Dungs, K.; Durante, P.; Dzhelyadin, R.; Dziurda, A.; Dzyuba, A.; Easo, S.; Egede, U.; Egorychev, V.; Eidelman, S.; Eisenhardt, S.; Eitschberger, U.; Ekelhof, R.; Eklund, L.; El Rifai, I.; Elsasser, Ch.; Ely, S.; Esen, S.; Evans, H. M.; Evans, T.; Falabella, A.; Farber, C.; Farley, N.; Farry, S.; Fay, R.; Fazzini, D.; Ferguson, D.; Fernandez Albor, V.; Ferrari, F.; Ferreira Rodrigues, F.; Ferro-Luzzi, M.; Filippov, S.; Fiore, M.; Fiorini, M.; Firlej, M.; Fitzpatrick, C.; Fiutowski, T.; Fleuret, F.; Fohl, K.; Fontana, M.; Fontanelli, F.; Forshaw, D. C.; Forty, R.; Frei, C.; Frosini, M.; Furfaro, E.; Gallas Torreira, A.; Galli, D.; Gallorini, S.; Gambetta, S.; Gandelman, M.; Gandini, P.; Garcia Pardinas, J.; Tico, J. Garra; Garrido, L.; Garsed, P. J.; Gascon, D.; Gaspar, C.; Gavardi, L.; Gazzoni, G.; Gerick, D.; Gersabeck, E.; Gersabeck, M.; Gershon, T.; Ghez, Ph.; Giani, S.; Gibson, V.; Girard, O. G.; Giubega, L.; Gligorov, V. V.; Gobel, C.; Golubkov, D.; Golutvin, A.; Gotti, C.; Gandara, M. Grabalosa; Graciani Diaz, R.; Cardoso, L. A. Granado; Grauges, E.; Graverini, E.; Graziani, G.; Grecu, A.; Griffith, P.; Grillo, L.; Gruenberg, O.; Gushchin, E.; Guz, Yu.; Gys, T.; Hadavizadeh, T.; Hadjivasiliou, C.; Haefeli, G.; Haen, C.; Haines, S. C.; Hall, S.; Hamilton, B.; Hansmann-Menzemer, S.; Harnew, N.; Harnew, S. T.; Harrison, J.; He, J.; Head, T.; Heister, A.; Hennessy, K.; Henrard, P.; Henry, L.; Hernando Morata, J. A.; van Herwijnen, E.; Hess, M.; Hicheur, A.; Hill, D.; Hoballah, M.; Hombach, C.; Hongming, L.; Hulsbergen, W.; Humair, T.; Hushchyn, M.; Hutchcroft, D.; Idzik, M.; Ilten, P.; Jacobsson, R.; Jalocha, J.; Jans, E.; Jawahery, A.; John, M.; Johnson, D.; Jones, C. R.; Joram, C.; Jost, B.; Jurik, N.; Kandybei, S.; Kanso, W.; Karacson, M.; Karbach, T. M.; Karodia, S.; Kecke, M.; Kelsey, M.; Kenyon, I. R.; Kenzie, M.; Ketel, T.; Khairullin, E.; Khanji, B.; Khurewathanakul, C.; Kirn, T.; Klaver, S.; Klimaszewski, K.; Kolpin, M.; Komarov, I.; Koppenburg, P.; Kozeiha, M.; Kravchuk, L.; Kreplin, K.; Kreps, M.; Krokovny, P.; Krzemien, W.; Kucewicz, W.; Kucharczyk, M.; Kudryavtsev, V.; Kuonen, A. K.; Kurek, K.; Kvaratskheliya, T.; Lacarrere, D.; Lafferty, G.; Lai, A.; Lambert, D.; Lanfranchi, G.; Langenbruch, C.; Langhans, B.; Latham, T.; Lazzeroni, C.; Le Gac, R.; van Leerdam, J.; Lees, J. -P.; Lefevre, R.; Leflat, A.; Lefrancois, J.; Cid, E. Lemos; Leroy, O.; Lesiak, T.; Leverington, B.; Likhomanenko, T.; Lindner, R.; Linn, C.; Lionetto, F.; Loh, D.; Longstaff, I.; Lopes, J. H.; Lucchesi, D.; Lucio Martinez, M.; Luo, H.; Lupato, A.; Luppi, E.; Lupton, O.; Lusardi, N.; Lusiani, A.; Lyu, X.; Machefert, F.; Maciuc, F.; Maev, O.; Maguire, K.; Malde, S.; Malinin, A.; Manca, G.; Mancinelli, G.; Manning, P.; Mapelli, A.; Maratas, J.; Marchand, J. F.; Marconi, U.; Marin Benito, C.; Marino, P.; Marks, J.; Martellotti, G.; Martinelli, M.; Martinez Santos, D.; Martinez Vidal, F.; Martins Tostes, D.; Massacrier, L. M.; Massafferri, A.; Matev, R.; Mathad, A.; Mathe, Z.; Matteuzzi, C.; Mauri, A.; Maurin, B.; Mazurov, A.; McCann, M.; McCarthy, J.; Mcnab, A.; McNulty, R.; Meadows, B.; Meier, F.; Melnychuk, D.; Merk, M.; Merli, A.; Michielin, E.; Milanes, D. A.; Minard, M. -N.; Mitzel, D. S.; Molina Rodriguez, J.; Monroy, I. A.; Monteil, S.; Morandin, M.; Morawski, P.; Morda, A.; Morello, M. J.; Moron, J.; Morris, A. B.; Mountain, R.; Muheim, F.; Mueller, J.; Mueller, K.; Mueller, V.; Mussini, M.; Muster, B.; Naik, P.; Nakada, T.; Nandakumar, R.; Nandi, A.; Nasteva, I.; Needham, M.; Neri, N.; Neubert, S.; Neufeld, N.; Neuner, M.; Nguyen, A. D.; Nguyen-Mau, C.; Niess, V.; Nieswand, S.; Niet, R.; Nikitin, N.; Nikodem, T.; Novoselov, A.; O'Hanlon, D. P.; Oblakowska-Mucha, A.; Obraztsov, V.; Ogilvy, S.; Okhrimenko, O.; Oldeman, R.; Onderwater, C. J. G.; Osorio Rodrigues, B.; Otalora Goicochea, J. M.; Otto, A.; Owen, P.; Oyanguren, A.; Palano, A.; Palombo, F.; Palutan, M.; Papanestis, A.; Pappagallo, M.; Pappalardo, L. L.; Pappenheimer, C.; Parker, W.; Parkes, C.; Passaleva, G.; Patel, G. D.; Patrignani, C.; Pearce, A.; Pellegrino, A.; Penso, G.; Altarelli, M. Pepe; Perazzini, S.; Perret, P.; Pescatore, L.; Petridis, K.; Petrolini, A.; Petruzzo, M.; Picatoste Olloqui, E.; Pietrzyk, B.; Pikies, M.; Pinci, D.; Pistone, A.; Piucci, A.; Playfer, S.; Plo Casasus, M.; Poikela, T.; Polci, F.; Poluektov, A.; Polyakov, I.; Polycarpo, E.; Popov, A.; Popov, D.; Popovici, B.; Potterat, C.; Price, E.; Price, J. D.; Prisciandaro, J.; Pritchard, A.; Prouve, C.; Pugatch, V.; Navarro, A. Puig; Punzi, G.; Qian, W.; Quagliani, R.; Rachwal, B.; Rademacker, J. H.; Rama, M.; Ramos Pernas, M.; Rangel, M. S.; Raniuk, I.; Raven, G.; Redi, F.; Reichert, S.; dos Reis, A. C.; Renaudin, V.; Ricciardi, S.; Richards, S.; Rihl, M.; Rinnert, K.; Rives Molina, V.; Rodrigues, A. B.; Rodrigues, E.; Rodriguez Lopez, J. A.; Perez, P. Rodriguez; Rogozhnikov, A.; Roiser, S.; Romanovsky, V.; Romero Vidal, A.; Ronayne, J. W.; Rotondo, M.; Ruf, T.; Valls, P. Ruiz; Saborido Silva, J. J.; Sagidova, N.; Saitta, B.; Salustino Guimaraes, V.; Sanchez Mayordomo, C.; Sanmartin Sedes, B.; Santacesaria, R.; Santamarina Rios, C.; Santimaria, M.; Santovetti, E.; Sarti, A.; Satriano, C.; Satta, A.; Saunders, D. M.; Savrina, D.; Schael, S.; Schindler, H.; Schlupp, M.; Schmelling, M.; Schmelzer, T.; Schmidt, B.; Schneider, O.; Schopper, A.; Schubiger, M.; Schune, M. -H.; Schwemmer, R.; Sciascia, B.; Sciubba, A.; Semennikov, A.; Sergi, A.; Serra, N.; Serrano, J.; Sestini, L.; Seyfert, P.; Shapkin, M.; Shapoval, I.; Shcheglov, Y.; Shears, T.; Shekhtman, L.; Shevchenko, V.; Shires, A.; Siddi, B. G.; Coutinho, R. Silva; Silva de Oliveira, L.; Simi, G.; Sirendi, M.; Skidmore, N.; Skwarnicki, T.; Smith, I. T.; Snoek, H.; Sokoloff, M. D.; Soler, F. J. P.; Soomro, F.; Souza, D.; Souza De Paula, B.; Spaan, B.; Spradlin, P.; Sridharan, S.; Stagni, F.; Stahl, M.; Stahl, S.; Stefkova, S.; Steinkamp, O.; Stenyakin, O.; Stevenson, S.; Stone, S.; Storaci, B.; Stracka, S.; Straticiuc, M.; Straumann, U.; Sutcliffe, W.; Swientek, K.; Swientek, S.; Syropoulos, V.; Szczekowski, M.; Szumlak, T.; T'Jampens, S.; Tayduganov, A.; Tekampe, T.; Tellarini, G.; Teubert, F.; van Tilburg, J.; Tisserand, V.; Tobin, M.; Tolk, S.; Tomassetti, L.; Tonelli, D.; Topp-Joergensen, S.; Tournefier, E.; Tourneur, S.; Trabelsi, K.; Traill, M.; Tresch, M.; Trisovic, A.; Tsaregorodtsev, A.; Tsopelas, P.; Tuning, N.; Ukleja, A.; Ustyuzhanin, A.; Uwer, U.; Vacca, C.; Vagnoni, V.; Valat, S.; Valenti, G.; Vallier, A.; Gomez, R. Vazquez; Vazquez Regueiro, P.; Vazquez Sierra, C.; Vecchi, S.; Velthuis, J. J.; Veltri, M.; Veneziano, G.; Vesterinen, M.; Viaud, B.; Vieira, D.; Vieites Diaz, M.; Vilasis-Cardona, X.; Volkov, V.; Vollhardt, A.; Voong, D.; Vorobyev, A.; Vorobyev, V.; Voss, C.; Waldi, R.; Wallace, C.; Wallace, R.; Ward, D. R.; Watson, N. K.; Websdale, D.; Weiden, A.; Whitehead, M.; Wicht, J.; Wilkinson, G.; Williams, T.; Wilson, F. F.; Wimberley, J.; Wishahi, J.; Wislicki, W.; Witek, M.; Wormser, G.; Wotton, S. A.; Wraight, K.; Wright, S.; Wyllie, K.; Xie, Y.; Yang, Z.; Yu, J.; Yuan, X.; Yushchenko, O.; Zangoli, M.; Zavertyaev, M.; Zhelezov, A.; Zheng, Y.; Zhokhov, A.; Zhong, L.; Zhukov, V.; Zucchelli, S.

    2016-01-01

    Violations of CPT symmetry and Lorentz invariance are searched for by studying interference effects in B-0 mixing and in B-s(0) mixing. Samples of B-0 -> J/psi K-S(0) and B-0(s) -> J/psi K+K- decays are recorded by the LHCb detector in proton-proton collisions at center-of-mass energies of 7 and 8

  14. No contact terms for the magnetic field in Lorentz- and CPT-violating electrodynamics

    Science.gov (United States)

    Schober, Karl; Altschul, Brett

    2016-09-01

    In a Lorentz- and CPT-violating modification of electrodynamics, the fields of a moving charge are known to have unusual singularities. This raises the question of whether the singular behavior may include δ-function contact terms, similar to those that appear in the fields of idealized dipoles. However, by calculating the magnetic field of an infinite straight wire in this theory, we demonstrate that there are no such contact terms in the magnetic field of a moving point charge.

  15. Violation of CPT and Quantum Mechanics in the K0--K0bar System

    OpenAIRE

    1994-01-01

    We reconsider the model of quantum mechanics violation in the $\\ko$--$\\kob$ system, due to Ellis, Hagelin, Nanopoulos, and Srednicki, in which \\cp- and \\cpt-violating signatures arise from the evolution of pure states into mixed states. We present a formalism for computing time-dependent asymmetries in this model and show that present data constrains its parameters significantly. In the future, this model will be put to very stringent tests at a $\\phi$ factory. We present the theory of these ...

  16. Search for Violations of Lorentz Invariance and CPT Symmetry in B_{(s)}^{0} Mixing.

    Science.gov (United States)

    Aaij, R; Abellán Beteta, C; Adeva, B; Adinolfi, M; Ajaltouni, Z; Akar, S; Albrecht, J; Alessio, F; Alexander, M; Ali, S; Alkhazov, G; Alvarez Cartelle, P; Alves, A A; Amato, S; Amerio, S; Amhis, Y; An, L; Anderlini, L; Andreassi, G; Andreotti, M; Andrews, J E; Appleby, R B; Aquines Gutierrez, O; Archilli, F; d'Argent, P; Artamonov, A; Artuso, M; Aslanides, E; Auriemma, G; Baalouch, M; Bachmann, S; Back, J J; Badalov, A; Baesso, C; Baker, S; Baldini, W; Barlow, R J; Barschel, C; Barsuk, S; Barter, W; Batozskaya, V; Battista, V; Bay, A; Beaucourt, L; Beddow, J; Bedeschi, F; Bediaga, I; Bel, L J; Bellee, V; Belloli, N; Belyaev, I; Ben-Haim, E; Bencivenni, G; Benson, S; Benton, J; Berezhnoy, A; Bernet, R; Bertolin, A; Betti, F; Bettler, M-O; van Beuzekom, M; Bifani, S; Billoir, P; Bird, T; Birnkraut, A; Bizzeti, A; Blake, T; Blanc, F; Blouw, J; Blusk, S; Bocci, V; Bondar, A; Bondar, N; Bonivento, W; Borgheresi, A; Borghi, S; Borisyak, M; Borsato, M; Boubdir, M; Bowcock, T J V; Bowen, E; Bozzi, C; Braun, S; Britsch, M; Britton, T; Brodzicka, J; Buchanan, E; Burr, C; Bursche, A; Buytaert, J; Cadeddu, S; Calabrese, R; Calvi, M; Calvo Gomez, M; Campana, P; Campora Perez, D; Capriotti, L; Carbone, A; Carboni, G; Cardinale, R; Cardini, A; Carniti, P; Carson, L; Carvalho Akiba, K; Casse, G; Cassina, L; Castillo Garcia, L; Cattaneo, M; Cauet, Ch; Cavallero, G; Cenci, R; Charles, M; Charpentier, Ph; Chatzikonstantinidis, G; Chefdeville, M; Chen, S; Cheung, S-F; Chrzaszcz, M; Cid Vidal, X; Ciezarek, G; Clarke, P E L; Clemencic, M; Cliff, H V; Closier, J; Coco, V; Cogan, J; Cogneras, E; Cogoni, V; Cojocariu, L; Collazuol, G; Collins, P; Comerma-Montells, A; Contu, A; Cook, A; Coombes, M; Coquereau, S; Corti, G; Corvo, M; Couturier, B; Cowan, G A; Craik, D C; Crocombe, A; Cruz Torres, M; Cunliffe, S; Currie, R; D'Ambrosio, C; Dall'Occo, E; Dalseno, J; David, P N Y; Davis, A; De Aguiar Francisco, O; De Bruyn, K; De Capua, S; De Cian, M; De Miranda, J M; De Paula, L; De Simone, P; Dean, C-T; Decamp, D; Deckenhoff, M; Del Buono, L; Déléage, N; Demmer, M; Derkach, D; Deschamps, O; Dettori, F; Dey, B; Di Canto, A; Di Ruscio, F; Dijkstra, H; Dordei, F; Dorigo, M; Dosil Suárez, A; Dovbnya, A; Dreimanis, K; Dufour, L; Dujany, G; Dungs, K; Durante, P; Dzhelyadin, R; Dziurda, A; Dzyuba, A; Easo, S; Egede, U; Egorychev, V; Eidelman, S; Eisenhardt, S; Eitschberger, U; Ekelhof, R; Eklund, L; El Rifai, I; Elsasser, Ch; Ely, S; Esen, S; Evans, H M; Evans, T; Falabella, A; Färber, C; Farley, N; Farry, S; Fay, R; Fazzini, D; Ferguson, D; Fernandez Albor, V; Ferrari, F; Ferreira Rodrigues, F; Ferro-Luzzi, M; Filippov, S; Fiore, M; Fiorini, M; Firlej, M; Fitzpatrick, C; Fiutowski, T; Fleuret, F; Fohl, K; Fontana, M; Fontanelli, F; Forshaw, D C; Forty, R; Frank, M; Frei, C; Frosini, M; Fu, J; Furfaro, E; Gallas Torreira, A; Galli, D; Gallorini, S; Gambetta, S; Gandelman, M; Gandini, P; Gao, Y; García Pardiñas, J; Garra Tico, J; Garrido, L; Garsed, P J; Gascon, D; Gaspar, C; Gavardi, L; Gazzoni, G; Gerick, D; Gersabeck, E; Gersabeck, M; Gershon, T; Ghez, Ph; Gianì, S; Gibson, V; Girard, O G; Giubega, L; Gligorov, V V; Göbel, C; Golubkov, D; Golutvin, A; Gomes, A; Gotti, C; Grabalosa Gándara, M; Graciani Diaz, R; Granado Cardoso, L A; Graugés, E; Graverini, E; Graziani, G; Grecu, A; Griffith, P; Grillo, L; Grünberg, O; Gushchin, E; Guz, Yu; Gys, T; Hadavizadeh, T; Hadjivasiliou, C; Haefeli, G; Haen, C; Haines, S C; Hall, S; Hamilton, B; Han, X; Hansmann-Menzemer, S; Harnew, N; Harnew, S T; Harrison, J; He, J; Head, T; Heister, A; Hennessy, K; Henrard, P; Henry, L; Hernando Morata, J A; van Herwijnen, E; Heß, M; Hicheur, A; Hill, D; Hoballah, M; Hombach, C; Hongming, L; Hulsbergen, W; Humair, T; Hushchyn, M; Hussain, N; Hutchcroft, D; Idzik, M; Ilten, P; Jacobsson, R; Jaeger, A; Jalocha, J; Jans, E; Jawahery, A; John, M; Johnson, D; Jones, C R; Joram, C; Jost, B; Jurik, N; Kandybei, S; Kanso, W; Karacson, M; Karbach, T M; Karodia, S; Kecke, M; Kelsey, M; Kenyon, I R; Kenzie, M; Ketel, T; Khairullin, E; Khanji, B; Khurewathanakul, C; Kirn, T; Klaver, S; Klimaszewski, K; Kolpin, M; Komarov, I; Koopman, R F; Koppenburg, P; Kozeiha, M; Kravchuk, L; Kreplin, K; Kreps, M; Krokovny, P; Kruse, F; Krzemien, W; Kucewicz, W; Kucharczyk, M; Kudryavtsev, V; Kuonen, A K; Kurek, K; Kvaratskheliya, T; Lacarrere, D; Lafferty, G; Lai, A; Lambert, D; Lanfranchi, G; Langenbruch, C; Langhans, B; Latham, T; Lazzeroni, C; Le Gac, R; van Leerdam, J; Lees, J-P; Lefèvre, R; Leflat, A; Lefrançois, J; Lemos Cid, E; Leroy, O; Lesiak, T; Leverington, B; Li, Y; Likhomanenko, T; Lindner, R; Linn, C; Lionetto, F; Liu, B; Liu, X; Loh, D; Longstaff, I; Lopes, J H; Lucchesi, D; Lucio Martinez, M; Luo, H; Lupato, A; Luppi, E; Lupton, O; Lusardi, N; Lusiani, A; Lyu, X; Machefert, F; Maciuc, F; Maev, O; Maguire, K; Malde, S; Malinin, A

    2016-06-17

    Violations of CPT symmetry and Lorentz invariance are searched for by studying interference effects in B^{0} mixing and in B_{s}^{0} mixing. Samples of B^{0}→J/ψK_{S}^{0} and B_{s}^{0}→J/ψK^{+}K^{-} decays are recorded by the LHCb detector in proton-proton collisions at center-of-mass energies of 7 and 8 TeV, corresponding to an integrated luminosity of 3  fb^{-1}. No periodic variations of the particle-antiparticle mass differences are found, consistent with Lorentz invariance and CPT symmetry. Results are expressed in terms of the standard model extension parameter Δa_{μ} with precisions of O(10^{-15}) and O(10^{-14})  GeV for the B^{0} and B_{s}^{0} systems, respectively. With no assumption on Lorentz (non)invariance, the CPT-violating parameter z in the B_{s}^{0} system is measured for the first time and found to be Re(z)=-0.022±0.033±0.005 and Im(z)=0.004±0.011±0.002, where the first uncertainties are statistical and the second systematic.

  17. A Test Of Cpt And Lorentz Symmetry Using A Potassium- Helium-3 Co-magnetometer

    CERN Document Server

    Kornack, T W

    2005-01-01

    A K-3He co-magnetometer has been developed for a test of Lorentz and CPT symmetry. Polarized K vapor forms a spin-exchange relaxation-free (SERF) magnetometer that has record sensitivity of about 1 fT/ Hz . The polarized 3He effectively suppresses sensitivity to the magnetic fields and gradients. Together, the K-3He co-magnetometer retains sensitivity to anomalous, CPT- and Lorentz- violating fields that couple to electron and nuclear spins differently than a normal magnetic field. Data over the course of 15 months provide upper limits on the coupling energy of a CPT-violating field to neutron spin, b˜n < 1.4 × 10−31 GeV, to proton spin, b˜p < 4.4 × 10−30 GeV, and to electron spin, b˜e < 1.0 × 10−28 GeV. These limits are consistent with the existing limits of b˜n < 1.1 × 10−31 GeV (Bear et al., 2002) and b˜ e < 3.0 × 10−29 Ge...

  18. Search for violations of Lorentz invariance and $CPT$ symmetry in $B^0_{(s)}$ mixing

    CERN Document Server

    Aaij, Roel; Adeva, Bernardo; Adinolfi, Marco; Ajaltouni, Ziad; Akar, Simon; Albrecht, Johannes; Alessio, Federico; Alexander, Michael; Ali, Suvayu; Alkhazov, Georgy; Alvarez Cartelle, Paula; Alves Jr, Antonio Augusto; Amato, Sandra; Amerio, Silvia; Amhis, Yasmine; An, Liupan; Anderlini, Lucio; Andreassi, Guido; Andreotti, Mirco; Andrews, Jason; Appleby, Robert; Aquines Gutierrez, Osvaldo; Archilli, Flavio; d'Argent, Philippe; Artamonov, Alexander; Artuso, Marina; Aslanides, Elie; Auriemma, Giulio; Baalouch, Marouen; Bachmann, Sebastian; Back, John; Badalov, Alexey; Baesso, Clarissa; Baker, Sophie; Baldini, Wander; Barlow, Roger; Barschel, Colin; Barsuk, Sergey; Barter, William; Batozskaya, Varvara; Battista, Vincenzo; Bay, Aurelio; Beaucourt, Leo; Beddow, John; Bedeschi, Franco; Bediaga, Ignacio; Bel, Lennaert; Bellee, Violaine; Belloli, Nicoletta; Belyaev, Ivan; Ben-Haim, Eli; Bencivenni, Giovanni; Benson, Sean; Benton, Jack; Berezhnoy, Alexander; Bernet, Roland; Bertolin, Alessandro; Betti, Federico; Bettler, Marc-Olivier; van Beuzekom, Martinus; Bifani, Simone; Billoir, Pierre; Bird, Thomas; Birnkraut, Alex; Bizzeti, Andrea; Blake, Thomas; Blanc, Frédéric; Blouw, Johan; Blusk, Steven; Bocci, Valerio; Bondar, Alexander; Bondar, Nikolay; Bonivento, Walter; Borgheresi, Alessio; Borghi, Silvia; Borisyak, Maxim; Borsato, Martino; Boubdir, Meriem; Bowcock, Themistocles; Bowen, Espen Eie; Bozzi, Concezio; Braun, Svende; Britsch, Markward; Britton, Thomas; Brodzicka, Jolanta; Buchanan, Emma; Burr, Christopher; Bursche, Albert; Buytaert, Jan; Cadeddu, Sandro; Calabrese, Roberto; Calvi, Marta; Calvo Gomez, Miriam; Campana, Pierluigi; Campora Perez, Daniel; Capriotti, Lorenzo; Carbone, Angelo; Carboni, Giovanni; Cardinale, Roberta; Cardini, Alessandro; Carniti, Paolo; Carson, Laurence; Carvalho Akiba, Kazuyoshi; Casse, Gianluigi; Cassina, Lorenzo; Castillo Garcia, Lucia; Cattaneo, Marco; Cauet, Christophe; Cavallero, Giovanni; Cenci, Riccardo; Charles, Matthew; Charpentier, Philippe; Chatzikonstantinidis, Georgios; Chefdeville, Maximilien; Chen, Shanzhen; Cheung, Shu-Faye; Chrzaszcz, Marcin; Cid Vidal, Xabier; Ciezarek, Gregory; Clarke, Peter; Clemencic, Marco; Cliff, Harry; Closier, Joel; Coco, Victor; Cogan, Julien; Cogneras, Eric; Cogoni, Violetta; Cojocariu, Lucian; Collazuol, Gianmaria; Collins, Paula; Comerma-Montells, Albert; Contu, Andrea; Cook, Andrew; Coombes, Matthew; Coquereau, Samuel; Corti, Gloria; Corvo, Marco; Couturier, Benjamin; Cowan, Greig; Craik, Daniel Charles; Crocombe, Andrew; Cruz Torres, Melissa Maria; Cunliffe, Samuel; Currie, Robert; D'Ambrosio, Carmelo; Dall'Occo, Elena; Dalseno, Jeremy; David, Pieter; Davis, Adam; De Aguiar Francisco, Oscar; De Bruyn, Kristof; De Capua, Stefano; De Cian, Michel; De Miranda, Jussara; De Paula, Leandro; De Simone, Patrizia; Dean, Cameron Thomas; Decamp, Daniel; Deckenhoff, Mirko; Del Buono, Luigi; Déléage, Nicolas; Demmer, Moritz; Derkach, Denis; Deschamps, Olivier; Dettori, Francesco; Dey, Biplab; Di Canto, Angelo; Di Ruscio, Francesco; Dijkstra, Hans; Dordei, Francesca; Dorigo, Mirco; Dosil Suárez, Alvaro; Dovbnya, Anatoliy; Dreimanis, Karlis; Dufour, Laurent; Dujany, Giulio; Dungs, Kevin; Durante, Paolo; Dzhelyadin, Rustem; Dziurda, Agnieszka; Dzyuba, Alexey; Easo, Sajan; Egede, Ulrik; Egorychev, Victor; Eidelman, Semen; Eisenhardt, Stephan; Eitschberger, Ulrich; Ekelhof, Robert; Eklund, Lars; El Rifai, Ibrahim; Elsasser, Christian; Ely, Scott; Esen, Sevda; Evans, Hannah Mary; Evans, Timothy; Falabella, Antonio; Färber, Christian; Farley, Nathanael; Farry, Stephen; Fay, Robert; Fazzini, Davide; Ferguson, Dianne; Fernandez Albor, Victor; Ferrari, Fabio; Ferreira Rodrigues, Fernando; Ferro-Luzzi, Massimiliano; Filippov, Sergey; Fiore, Marco; Fiorini, Massimiliano; Firlej, Miroslaw; Fitzpatrick, Conor; Fiutowski, Tomasz; Fleuret, Frederic; Fohl, Klaus; Fontana, Marianna; Fontanelli, Flavio; Forshaw, Dean Charles; Forty, Roger; Frank, Markus; Frei, Christoph; Frosini, Maddalena; Fu, Jinlin; Furfaro, Emiliano; Gallas Torreira, Abraham; Galli, Domenico; Gallorini, Stefano; Gambetta, Silvia; Gandelman, Miriam; Gandini, Paolo; Gao, Yuanning; García Pardiñas, Julián; Garra Tico, Jordi; Garrido, Lluis; Garsed, Philip John; Gascon, David; Gaspar, Clara; Gavardi, Laura; Gazzoni, Giulio; Gerick, David; Gersabeck, Evelina; Gersabeck, Marco; Gershon, Timothy; Ghez, Philippe; Gianì, Sebastiana; Gibson, Valerie; Girard, Olivier Göran; Giubega, Lavinia-Helena; Gligorov, V.V.; Göbel, Carla; Golubkov, Dmitry; Golutvin, Andrey; Gomes, Alvaro; Gotti, Claudio; Grabalosa Gándara, Marc; Graciani Diaz, Ricardo; Granado Cardoso, Luis Alberto; Graugés, Eugeni; Graverini, Elena; Graziani, Giacomo; Grecu, Alexandru; Griffith, Peter; Grillo, Lucia; Grünberg, Oliver; Gushchin, Evgeny; Guz, Yury; Gys, Thierry; Hadavizadeh, Thomas; Hadjivasiliou, Christos; Haefeli, Guido; Haen, Christophe; Haines, Susan; Hall, Samuel; Hamilton, Brian; Han, Xiaoxue; Hansmann-Menzemer, Stephanie; Harnew, Neville; Harnew, Samuel; Harrison, Jonathan; He, Jibo; Head, Timothy; Heister, Arno; Hennessy, Karol; Henrard, Pierre; Henry, Louis; Hernando Morata, Jose Angel; van Herwijnen, Eric; Heß, Miriam; Hicheur, Adlène; Hill, Donal; Hoballah, Mostafa; Hombach, Christoph; Hongming, Li; Hulsbergen, Wouter; Humair, Thibaud; Hushchyn, Mikhail; Hussain, Nazim; Hutchcroft, David; Idzik, Marek; Ilten, Philip; Jacobsson, Richard; Jaeger, Andreas; Jalocha, Pawel; Jans, Eddy; Jawahery, Abolhassan; John, Malcolm; Johnson, Daniel; Jones, Christopher; Joram, Christian; Jost, Beat; Jurik, Nathan; Kandybei, Sergii; Kanso, Walaa; Karacson, Matthias; Karbach, Moritz; Karodia, Sarah; Kecke, Matthieu; Kelsey, Matthew; Kenyon, Ian; Kenzie, Matthew; Ketel, Tjeerd; Khairullin, Egor; Khanji, Basem; Khurewathanakul, Chitsanu; Kirn, Thomas; Klaver, Suzanne; Klimaszewski, Konrad; Kolpin, Michael; Komarov, Ilya; Koopman, Rose; Koppenburg, Patrick; Kozeiha, Mohamad; Kravchuk, Leonid; Kreplin, Katharina; Kreps, Michal; Krokovny, Pavel; Kruse, Florian; Krzemien, Wojciech; Kucewicz, Wojciech; Kucharczyk, Marcin; Kudryavtsev, Vasily; Kuonen, Axel Kevin; Kurek, Krzysztof; Kvaratskheliya, Tengiz; Lacarrere, Daniel; Lafferty, George; Lai, Adriano; Lambert, Dean; Lanfranchi, Gaia; Langenbruch, Christoph; Langhans, Benedikt; Latham, Thomas; Lazzeroni, Cristina; Le Gac, Renaud; van Leerdam, Jeroen; Lees, Jean-Pierre; Lefèvre, Regis; Leflat, Alexander; Lefrançois, Jacques; Lemos Cid, Edgar; Leroy, Olivier; Lesiak, Tadeusz; Leverington, Blake; Li, Yiming; Likhomanenko, Tatiana; Lindner, Rolf; Linn, Christian; Lionetto, Federica; Liu, Bo; Liu, Xuesong; Loh, David; Longstaff, Iain; Lopes, Jose; Lucchesi, Donatella; Lucio Martinez, Miriam; Luo, Haofei; Lupato, Anna; Luppi, Eleonora; Lupton, Oliver; Lusardi, Nicola; Lusiani, Alberto; Lyu, Xiao-Rui; Machefert, Frederic; Maciuc, Florin; Maev, Oleg; Maguire, Kevin; Malde, Sneha; Malinin, Alexander; Manca, Giulia; Mancinelli, Giampiero; Manning, Peter Michael; Mapelli, Alessandro; Maratas, Jan; Marchand, Jean François; Marconi, Umberto; Marin Benito, Carla; Marino, Pietro; Marks, Jörg; Martellotti, Giuseppe; Martin, Morgan; Martinelli, Maurizio; Martinez Santos, Diego; Martinez Vidal, Fernando; Martins Tostes, Danielle; Massacrier, Laure Marie; Massafferri, André; Matev, Rosen; Mathad, Abhijit; Mathe, Zoltan; Matteuzzi, Clara; Mauri, Andrea; Maurin, Brice; Mazurov, Alexander; McCann, Michael; McCarthy, James; McNab, Andrew; McNulty, Ronan; Meadows, Brian; Meier, Frank; Meissner, Marco; Melnychuk, Dmytro; Merk, Marcel; Merli, Andrea; Michielin, Emanuele; Milanes, Diego Alejandro; Minard, Marie-Noelle; Mitzel, Dominik Stefan; Molina Rodriguez, Josue; Monroy, Ignacio Alberto; Monteil, Stephane; Morandin, Mauro; Morawski, Piotr; Mordà, Alessandro; Morello, Michael Joseph; Moron, Jakub; Morris, Adam Benjamin; Mountain, Raymond; Muheim, Franz; Müller, Dominik; Müller, Janine; Müller, Katharina; Müller, Vanessa; Mussini, Manuel; Muster, Bastien; Naik, Paras; Nakada, Tatsuya; Nandakumar, Raja; Nandi, Anita; Nasteva, Irina; Needham, Matthew; Neri, Nicola; Neubert, Sebastian; Neufeld, Niko; Neuner, Max; Nguyen, Anh Duc; Nguyen-Mau, Chung; Niess, Valentin; Nieswand, Simon; Niet, Ramon; Nikitin, Nikolay; Nikodem, Thomas; Novoselov, Alexey; O'Hanlon, Daniel Patrick; Oblakowska-Mucha, Agnieszka; Obraztsov, Vladimir; Ogilvy, Stephen; Okhrimenko, Oleksandr; Oldeman, Rudolf; Onderwater, Gerco; Osorio Rodrigues, Bruno; Otalora Goicochea, Juan Martin; Otto, Adam; Owen, Patrick; Oyanguren, Maria Aranzazu; Palano, Antimo; Palombo, Fernando; Palutan, Matteo; Panman, Jacob; Papanestis, Antonios; Pappagallo, Marco; Pappalardo, Luciano; Pappenheimer, Cheryl; Parker, William; Parkes, Christopher; Passaleva, Giovanni; Patel, Girish; Patel, Mitesh; Patrignani, Claudia; Pearce, Alex; Pellegrino, Antonio; Penso, Gianni; Pepe Altarelli, Monica; Perazzini, Stefano; Perret, Pascal; Pescatore, Luca; Petridis, Konstantinos; Petrolini, Alessandro; Petruzzo, Marco; Picatoste Olloqui, Eduardo; Pietrzyk, Boleslaw; Pikies, Malgorzata; Pinci, Davide; Pistone, Alessandro; Piucci, Alessio; Playfer, Stephen; Plo Casasus, Maximo; Poikela, Tuomas; Polci, Francesco; Poluektov, Anton; Polyakov, Ivan; Polycarpo, Erica; Popov, Alexander; Popov, Dmitry; Popovici, Bogdan; Potterat, Cédric; Price, Eugenia; Price, Joseph David; Prisciandaro, Jessica; Pritchard, Adrian; Prouve, Claire; Pugatch, Valery; Puig Navarro, Albert; Punzi, Giovanni; Qian, Wenbin; Quagliani, Renato; Rachwal, Bartolomiej; Rademacker, Jonas; Rama, Matteo; Ramos Pernas, Miguel; Rangel, Murilo; Raniuk, Iurii; Raven, Gerhard; Redi, Federico; Reichert, Stefanie; dos Reis, Alberto; Renaudin, Victor; Ricciardi, Stefania; Richards, Sophie; Rihl, Mariana; Rinnert, Kurt; Rives Molina, Vincente; Robbe, Patrick; Rodrigues, Ana Barbara; Rodrigues, Eduardo; Rodriguez Lopez, Jairo Alexis; Rodriguez Perez, Pablo; Rogozhnikov, Alexey; Roiser, Stefan; Romanovsky, Vladimir; Romero Vidal, Antonio; Ronayne, John William; Rotondo, Marcello; Ruf, Thomas; Ruiz Valls, Pablo; Saborido Silva, Juan Jose; Sagidova, Naylya; Saitta, Biagio; Salustino Guimaraes, Valdir; Sanchez Mayordomo, Carlos; Sanmartin Sedes, Brais; Santacesaria, Roberta; Santamarina Rios, Cibran; Santimaria, Marco; Santovetti, Emanuele; Sarti, Alessio; Satriano, Celestina; Satta, Alessia; Saunders, Daniel Martin; Savrina, Darya; Schael, Stefan; Schiller, Manuel; Schindler, Heinrich; Schlupp, Maximilian; Schmelling, Michael; Schmelzer, Timon; Schmidt, Burkhard; Schneider, Olivier; Schopper, Andreas; Schubiger, Maxime; Schune, Marie Helene; Schwemmer, Rainer; Sciascia, Barbara; Sciubba, Adalberto; Semennikov, Alexander; Sergi, Antonino; Serra, Nicola; Serrano, Justine; Sestini, Lorenzo; Seyfert, Paul; Shapkin, Mikhail; Shapoval, Illya; Shcheglov, Yury; Shears, Tara; Shekhtman, Lev; Shevchenko, Vladimir; Shires, Alexander; Siddi, Benedetto Gianluca; Silva Coutinho, Rafael; Silva de Oliveira, Luiz Gustavo; Simi, Gabriele; Sirendi, Marek; Skidmore, Nicola; Skwarnicki, Tomasz; Smith, Eluned; Smith, Iwan Thomas; Smith, Jackson; Smith, Mark; Snoek, Hella; Sokoloff, Michael; Soler, Paul; Soomro, Fatima; Souza, Daniel; Souza De Paula, Bruno; Spaan, Bernhard; Spradlin, Patrick; Sridharan, Srikanth; Stagni, Federico; Stahl, Marian; Stahl, Sascha; Stefkova, Slavomira; Steinkamp, Olaf; Stenyakin, Oleg; Stevenson, Scott; Stoica, Sabin; Stone, Sheldon; Storaci, Barbara; Stracka, Simone; Straticiuc, Mihai; Straumann, Ulrich; Sun, Liang; Sutcliffe, William; Swientek, Krzysztof; Swientek, Stefan; Syropoulos, Vasileios; Szczekowski, Marek; Szumlak, Tomasz; T'Jampens, Stephane; Tayduganov, Andrey; Tekampe, Tobias; Tellarini, Giulia; Teubert, Frederic; Thomas, Christopher; Thomas, Eric; van Tilburg, Jeroen; Tisserand, Vincent; Tobin, Mark; Tolk, Siim; Tomassetti, Luca; Tonelli, Diego; Topp-Joergensen, Stig; Tournefier, Edwige; Tourneur, Stephane; Trabelsi, Karim; Traill, Murdo; Tran, Minh Tâm; Tresch, Marco; Trisovic, Ana; Tsaregorodtsev, Andrei; Tsopelas, Panagiotis; Tuning, Niels; Ukleja, Artur; Ustyuzhanin, Andrey; Uwer, Ulrich; Vacca, Claudia; Vagnoni, Vincenzo; Valat, Sebastien; Valenti, Giovanni; Vallier, Alexis; Vazquez Gomez, Ricardo; Vazquez Regueiro, Pablo; Vázquez Sierra, Carlos; Vecchi, Stefania; van Veghel, Maarten; Velthuis, Jaap; Veltri, Michele; Veneziano, Giovanni; Vesterinen, Mika; Viaud, Benoit; Vieira, Daniel; Vieites Diaz, Maria; Vilasis-Cardona, Xavier; Volkov, Vladimir; Vollhardt, Achim; Voong, David; Vorobyev, Alexey; Vorobyev, Vitaly; Voß, Christian; de Vries, Jacco; Waldi, Roland; Wallace, Charlotte; Wallace, Ronan; Walsh, John; Wang, Jianchun; Ward, David; Watson, Nigel; Websdale, David; Weiden, Andreas; Whitehead, Mark; Wicht, Jean; Wilkinson, Guy; Wilkinson, Michael; Williams, Mark Richard James; Williams, Matthew; Williams, Mike; Williams, Timothy; Wilson, Fergus; Wimberley, Jack; Wishahi, Julian; Wislicki, Wojciech; Witek, Mariusz; Wormser, Guy; Wotton, Stephen; Wraight, Kenneth; Wright, Simon; Wyllie, Kenneth; Xie, Yuehong; Xu, Zhirui; Yang, Zhenwei; Yin, Hang; Yu, Jiesheng; Yuan, Xuhao; Yushchenko, Oleg; Zangoli, Maria; Zavertyaev, Mikhail; Zhang, Liming; Zhang, Yanxi; Zhelezov, Alexey; Zheng, Yangheng; Zhokhov, Anatoly; Zhong, Liang; Zhukov, Valery; Zucchelli, Stefano

    2016-01-01

    Violations of $ CPT$ symmetry and Lorentz invariance are searched for by studying interference effects in $ B^0$ mixing and in $ B^0_s$ mixing. Samples of $ B^0\\to J/\\psi K^0_{\\mathrm{S}}$ and $ B^0_s\\to J/\\psi K^+ K^-$ decays are recorded by the LHCb detector in proton--proton collisions at centre-of-mass energies of 7 and 8 TeV, corresponding to an integrated luminosity of 3 fb$^{-1}$. No periodic variations of the particle-antiparticle mass differences are found, consistent with Lorentz invariance and $ CPT$ symmetry. Results are expressed in terms of the Standard Model Extension parameter $\\Delta a_{\\mu}$ with precisions of $ \\mathcal{O}(10^{-15})$ and $ \\mathcal{O}(10^{-14})$ GeV for the $ B^0$ and $ B^0_s$ systems, respectively. With no assumption on Lorentz (non-)invariance, the $ CPT$-violating parameter $z$ in the $ B^0_s$ system is measured for the first time and found to be $ \\mathcal{R}e(z) = -0.022 \\pm 0.033 \\pm 0.005$ and $ \\mathcal{I}m(z) = 0.004 \\pm 0.011\\pm 0.002$, where the first uncertainti...

  19. Extension of the $CPT$ Theorem to non-Hermitian Hamiltonians and Unstable States

    CERN Document Server

    Mannheim, Philip D

    2016-01-01

    We extend the $CPT$ theorem to quantum field theories with non-Hermitian Hamiltonians and unstable states. Our derivation is a quite minimal one as it requires only the time independent evolution of scalar products, invariance under complex Lorentz transformations, and a non-standard but nonetheless perfectly legitimate interpretation of charge conjugation as an anti-linear operator. The first of these requirements does not force the Hamiltonian to be Hermitian. Rather, it forces its eigenvalues to either be real or to appear in complex conjugate pairs, forces the eigenvectors of such conjugate pairs to be conjugates of each other, and forces the Hamiltonian to admit of an anti-linear symmetry. The latter two requirements then force this anti-linear symmetry to be $CPT$, while forcing the Hamiltonian to be real rather than Hermitian. Our work justifies the use of the $CPT$ theorem in establishing the equality of the lifetimes of unstable particles that are charge conjugates of each other. We show that the Euc...

  20. Probing Lorentz and CPT Violation in a Magnetized Iron Detector using Atmospheric Neutrinos

    CERN Document Server

    Chatterjee, Animesh; Singh, Jyotsna

    2014-01-01

    We study the sensitivity of the Iron Calorimeter (ICAL) at the India-Based Neutrino Observatory (INO) to Lorentz and CPT violation in the neutrino sector. Its ability to identify the charge of muons in addition to their direction and energy makes ICAL a useful tool in putting constraints on these fundamental symmetries. Using resolution, efficiencies, errors and uncertainties obtained from ICAL detector simulations, we determine sensitivities to $\\delta{b}_{31}$, which parametizes the violations in the muon neutrino sector. We carry out calculations for three generic cases representing mixing in the CPT violating part of the hamiltonian, specifically, when the mixing is 1) small, 2) large, 3) the same as that in the PMNS matrix. We find that for both types of hierarchy, ICAL at INO should be sensitive to $\\delta{b}_{31}$ $\\gtrsim$ $4\\times10^{-23}$ GeV at 99% C.L. for 500 kt-yr exposure, unless the mixing in the CPT violation sector is small.

  1. Density and undrained shear strength of bed sediment from ND-CPT

    Science.gov (United States)

    Jia, Rui; Hino, Takenori; Hamada, Takaharu; Chai, Jinchun; Yoshimura, Mitsugu

    2013-05-01

    The density and the undrained shear strength ( s u) of bed sediments at either side of the Isahaya Bay dike in the Ariake Sea, Japan, were investigated using nuclear density cone penetration tests (ND-CPTs). The nuclear density cone penetrometer (ND-CP) was operated from a boat, conducting 71 ND-CPTs. Furthermore, 26 undisturbed samples were obtained for soil density and s u measurements to calibrate the ND-CPT data. The results show that the density and s u obtained from in situ with the ND-CPTs agree well with those from the laboratory tests on undisturbed samples, and the obtained density profiles show good repeatability. The vertical variation in density and s u of the bed sediment can be obtained from the ND-CPT results. The relations between the density and s u show that s u increases with an increase in density, but that this relation is site specific. The values of s u show an exponentially growing trend and the values of log s u show a linearly increasing trend with density. The vertical distribution of the bed sediments can be described using the density values obtained with the ND-CPT.

  2. Impediments to Enhancement of CPT-11 Anticancer Activity by E. coli Directed Beta-Glucuronidase Therapy

    Science.gov (United States)

    Hsieh, Yuan-Ting; Chen, Kai-Chuan; Cheng, Chiu-Min; Cheng, Tian-Lu; Tao, Mi-Hua; Roffler, Steve R.

    2015-01-01

    CPT-11 is a camptothecin analog used for the clinical treatment of colorectal adenocarcinoma. CPT-11 is converted into the therapeutic anti-cancer agent SN-38 by liver enzymes and can be further metabolized to a non-toxic glucuronide SN-38G, resulting in low SN-38 but high SN-38G concentrations in the circulation. We previously demonstrated that adenoviral expression of membrane-anchored beta-glucuronidase could promote conversion of SN-38G to SN-38 in tumors and increase the anticancer activity of CPT-11. Here, we identified impediments to effective tumor therapy with E. coli that were engineered to constitutively express highly active E. coli beta-glucuronidase intracellularly to enhance the anticancer activity of CPT-11. The engineered bacteria, E. coli (lux/βG), could hydrolyze SN-38G to SN-38, increased the sensitivity of cultured tumor cells to SN-38G by about 100 fold and selectively accumulated in tumors. However, E. coli (lux/βG) did not more effectively increase CPT-11 anticancer activity in human tumor xenografts as compared to non-engineered E. coli. SN-38G conversion to SN-38 by E. coli (lux/βG) appeared to be limited by slow uptake into bacteria as well as by segregation of E. coli in necrotic regions of tumors that may be relatively inaccessible to systemically-administered drug molecules. Studies using a fluorescent glucuronide probe showed that significantly greater glucuronide hydrolysis could be achieved in mice pretreated with E. coli (lux/βG) by direct intratumoral injection of the glucuronide probe or by intratumoral lysis of bacteria to release intracellular beta-glucuronidase. Our study suggests that the distribution of beta-glucuronidase, and possibly other therapeutic proteins, in the tumor microenvironment might be an important barrier for effective bacterial-based tumor therapy. Expression of secreted therapeutic proteins or induction of therapeutic protein release from bacteria might therefore be a promising strategy to enhance anti

  3. Impediments to enhancement of CPT-11 anticancer activity by E. coli directed beta-glucuronidase therapy.

    Science.gov (United States)

    Hsieh, Yuan-Ting; Chen, Kai-Chuan; Cheng, Chiu-Min; Cheng, Tian-Lu; Tao, Mi-Hua; Roffler, Steve R

    2015-01-01

    CPT-11 is a camptothecin analog used for the clinical treatment of colorectal adenocarcinoma. CPT-11 is converted into the therapeutic anti-cancer agent SN-38 by liver enzymes and can be further metabolized to a non-toxic glucuronide SN-38G, resulting in low SN-38 but high SN-38G concentrations in the circulation. We previously demonstrated that adenoviral expression of membrane-anchored beta-glucuronidase could promote conversion of SN-38G to SN-38 in tumors and increase the anticancer activity of CPT-11. Here, we identified impediments to effective tumor therapy with E. coli that were engineered to constitutively express highly active E. coli beta-glucuronidase intracellularly to enhance the anticancer activity of CPT-11. The engineered bacteria, E. coli (lux/βG), could hydrolyze SN-38G to SN-38, increased the sensitivity of cultured tumor cells to SN-38G by about 100 fold and selectively accumulated in tumors. However, E. coli (lux/βG) did not more effectively increase CPT-11 anticancer activity in human tumor xenografts as compared to non-engineered E. coli. SN-38G conversion to SN-38 by E. coli (lux/βG) appeared to be limited by slow uptake into bacteria as well as by segregation of E. coli in necrotic regions of tumors that may be relatively inaccessible to systemically-administered drug molecules. Studies using a fluorescent glucuronide probe showed that significantly greater glucuronide hydrolysis could be achieved in mice pretreated with E. coli (lux/βG) by direct intratumoral injection of the glucuronide probe or by intratumoral lysis of bacteria to release intracellular beta-glucuronidase. Our study suggests that the distribution of beta-glucuronidase, and possibly other therapeutic proteins, in the tumor microenvironment might be an important barrier for effective bacterial-based tumor therapy. Expression of secreted therapeutic proteins or induction of therapeutic protein release from bacteria might therefore be a promising strategy to enhance anti

  4. Entangled Bd mesons and genuine T, CP and CPT asymmetry parameters

    Science.gov (United States)

    Nebot, Miguel

    2017-07-01

    We establish the precise connection between the theoretical T, CP, CPT asymmetries, in terms of transition probabilities between the neutral meson Bd states, and the experimental asymmetries, in terms of the double decay rate intensities for Flavour-CP eigenstate decay products in a B-Factory of entangled states. Genuine asymmetry parameters in the time distribution of the asymmetries are identified and their measurability analysed, disentangling genuine and possible fake terms. The nine asymmetry parameters - three different observables for each one of the three symmetries - are expressed in terms of the ingredients of the Weisskopf-Wigner dynamical description of the entangled Bd -meson states and we obtain a global fit to their values from the BaBar Collaboration experimental results. The possible fake terms are all compatible with zero. The information content of the nine asymmetry parameters is indeed different. The non-vanishing {{Δ }}{{\\mathscr{l}}}c{{T}}=-0.687+/- 0.020 and {{Δ }}{{\\mathscr{l}}}c{{CP}}=-0.680+/- 0.021 are impressive separate direct evidence of Time-Reversal-Violation and CP-Violation in these transitions (and compatible with Standard Model expectations). A 2σ effect for the Re(θ) parameter responsible of CPT-Violation appears; interpreted as an upper limit, it leads to |{M}{\\bar{B}0{\\bar{B}}0}-{M}{B0{B}0}|adding an Entanglement-weakening term of the wrong exchange symmetry, the ω-effect. The analysis is extended to identify how to probe the complex ω when the connection between the Intensities for the two time-ordered decays (f, g) and (g, f) is lost (f flavour and g CP eigenstate decay channels), and how the ω-effect is disentangled from CPT violation in the evolution Hamiltonian.

  5. Aspects of CPT-even Lorentz-symmetry violating physics in a supersymmetric scenario

    Energy Technology Data Exchange (ETDEWEB)

    Belich, H. [Universidade Federal do Espirito Santo, Departamento de Fisica e Quimica, Vitoria, ES (Brazil); Universidade Federal do Para, Faculdade de Fisica, Belem, Para (Brazil); Bernald, L.D.; Helayel-Neto, J.A. [Centro Brasileiro de Pesquisas Fisicas, Rio de Janeiro, RJ (Brazil); Gaete, Patricio [Universidad Tecnica Federico Santa Maria, Departmento de Fisica and Centro Cientifico-Tecnologico de Valparaiso, Valparaiso (Chile); Leal, F.J.L. [Ciencia e Tecnologia do Espirito Santo, Instituto Federal de Educacao, Vitoria, ES (Brazil)

    2015-06-15

    Background fermion condensates in a landscape dominated by global supersymmetry are reassessed in connection with a scenario where Lorentz symmetry is violated in the bosonic sector (actually, the photon sector) by a CPT-even k{sub F} term. An effective photonic action is discussed that originates from the supersymmetric background fermion condensates. Also, the photino mass emerges in terms of a particular condensate contrary to what happens in the case of k{sub AF}-violation. Finally, the interparticle potential induced by the effective photonic action is investigated and a confining profile is identified. (orig.)

  6. Bound on Lorentz and CPT violating boost effects for the neutron.

    Science.gov (United States)

    Canè, F; Bear, D; Phillips, D F; Rosen, M S; Smallwood, C L; Stoner, R E; Walsworth, R L; Kostelecký, V Alan

    2004-12-03

    A search for an annual variation of a daily sidereal modulation of the frequency difference between colocated 129Xe and 3He Zeeman masers sets a stringent limit on boost-dependent Lorentz and CPT violation involving the neutron, consistent with no effect at the level of 150 nHz. In the framework of the general standard-model extension, the present result provides the first clean test for the fermion sector of the symmetry of spacetime under boost transformations at a level of 10(-27) GeV.

  7. A new CPT-even and Lorentz-Violating nonminimal coupling in the Dirac equation

    CERN Document Server

    Casana, R; Silva, E O; Passos, E; Santos, F E P dos

    2013-01-01

    In this work, we propose a CPT-even and Lorentz-violating dimension-five nonminimal coupling between fermionic and gauge fields, involving the CTP-even and Lorentz-violating gauge tensor of the SME. This nonminimal coupling modifies the Dirac equation, whose nonrelativistic regime is governed by a Hamiltonian which induces new effects, such as an electric-Zeeman-like spectrum splitting and an anomalous-like contribution to the electron magnetic moment, between others. Some of these new effects allows to constrain the magnitude of this nonminimal coupling in 1 part in 10^16.

  8. Aspects of a planar nonbirefringent and CPT-even electrodynamics stemming from the Standard Model Extension

    CERN Document Server

    Casana, Rodolfo; Moreira, Roemir P M

    2011-01-01

    We have studied a (1+2)-dimensional Lorentz-violating model which is obtained from the dimensional reduction of the nonbirefringent sector of the CPT-even electrodynamics of the standard model extension (SME). The planar theory contains a gauge sector and a scalar sector which are linearly coupled by means of a Lorentz-invariance violating (LIV) vector, $S^{\\mu}$, while the kinetic terms of both sectors are affected by the components of a Lorentz-violating symmetric tensor, $\\kappa^{\\mu\

  9. On the duality in CPT-even Lorentz-breaking theories

    Energy Technology Data Exchange (ETDEWEB)

    Scarpelli, A.P.B. [Departamento de Policia Federal, Sao Paulo (Brazil); Ribeiro, R.F.; Nascimento, J.R.; Petrov, A.Yu. [Universidade Federal da Paraiba, Departamento de Fisica (Brazil)

    2015-07-15

    We generalize the duality between self-dual and Maxwell-Chern-Simons theories for the case of a CPT-even Lorentz-breaking extension of these theories. The duality is shown using the gauge embedding procedure, both in free and coupled cases, and with the master action approach. The physical spectra of both Lorentz-breaking theories are studied. The massive poles are shown to coincide and to respect the requirements for unitarity and causality at tree level. The extra massless poles which are present in the dualized model are shown to be nondynamical. (orig.)

  10. Consistency in Perturbative Calculations and Radiatively Induced Lorentz and CPT Violations

    CERN Document Server

    Battistel, O A

    2002-01-01

    The origin of the radiatively induced Lorentz and CPT violations, in perturbative evaluations, of an extended version of QED, is investigated. Using a very general calculational method, concerning the manipulations and calculations involving divergent amplitudes, we clearly identify the possible sources of contributions for the violating terms. We show that consistency in the perturbative calculations, in a broader sense, leaves no room for the existence of radiatively induced contributions which is in accordance with what was previously conjectured and recently advocated by some authors supported on general arguments.

  11. Investigation of Dense Sand Properties in Shallow Depth using CPT and DMT

    DEFF Research Database (Denmark)

    Gaydadzhiew, Dimitar Todorov; Puscasu, Ionut; Vaitkunaite, Evelina;

    2015-01-01

    ABSTRACT: The present paper is an investigation of the soil parameters of the given Aalborg University Sand No. 1 using the Flat Dilatometer Test (DMT) and the Cone Penetration Test (CPT). This clean sand type is considered to be similar to the sands found in the North Sea area. The research...... is mainly based on experimental laboratory testing, followed by computer assisted data interpretation. The mentioned tools are used in testing the sand properties in shallow depth and examining any occurrence of an effect induced by the limited size of the laboratory set-up....

  12. Testing CPT and Quantum Mechanics in the K_0-Kbar_0 System

    OpenAIRE

    1994-01-01

    I report a recent study done in collaboration with M.E. Peskin, on the time dependence of a kaon beam propagating according to a generalization of quantum mechanics due to Ellis, Hagelin, Nanopoulos and Srednicki, in which CP- and CPT-violating signatures arise from the evolution of pure states to mixed states. Constraints on the magnitude of its parameters are established on the basis of existing experimental data. New facilities such as phi-factories are shown to be particularly adequate to...

  13. Violation of CPT and quantum mechanics in the K$_{0}$-$\\overline{K}_{0}$ system

    CERN Document Server

    Huet, Patrick; Patrick Huet; Michael E Peskin

    1994-01-01

    We reconsider the model of quantum mechanics violation in the K.sup(0)-K.bar.sup(0) system, due to Ellis, Hagelin, Nanopoulos, and Srednicki, in which CP- and CPT-violating signatures arise from the evolution of pure states into mixed states. We present a formalism for computing time-dependent asymmetries in this model and show that present data constrains its parameters signficantly. In the future, this model will be put to very stringent tests at a phi factory. We present the theory of these tests and show the relation between particular phi decay correlations and the parameters of quantum mechanics violation.

  14. Aspects of CPT-even Lorentz-symmetry violating physics in a supersymmetric scenario

    CERN Document Server

    Belich, H; Helayël-Neto, Patricio Gaete J A; Leal, F J L

    2015-01-01

    Background fermion condensates in a landscape dominated by global SUSY are reassessed in connection with a scenario where Lorentz symmetry is violated in the bosonic sector (actually, the photon sector) by a $CPT$-even $k_F$-term. An effective photonic action is discussed that originates from the supersymmetric background fermion condensates. Also, the photino mass emerges in terms of a particular condensate contrary to what happens in the $k_{AF}$-violation. Finally, the interparticle potential induced by the effective photonic action is investigated and a confining profile is identified.

  15. Tests of Lorentz and CPT Violation in the Medium Baseline Reactor Antineutrino Experiment

    CERN Document Server

    Li, Yu-Feng

    2014-01-01

    Tests of Lorentz and CPT violation in the medium baseline reactor antineutrino experiment are presented in the framework of the Standard Model Extension (SME). Both the spectral distortion and sidereal variation are employed to derive the limits of Lorentz violation (LV) coefficients. We do the numerical analysis of the sensitivity of LV coefficients by taking the Jiangmen Underground Neutrino Observatory (JUNO) as an illustration, which can improve the sensitivity by more than two orders of magnitude compared with the current limits from reactor antineutrino experiments.

  16. Study of KS semileptonic decays and CPT test with the KLOE detector

    CERN Document Server

    Kamińska, Daria

    2015-01-01

    Study of semileptonic decays of neutral kaons allows to perform a test of discrete symmetries, as well as basic principles of the Standard Model. In this paper a general review on dependency between charge asymmetry constructed for semileptonic decays of short- and long-lived kaons and CPT symmetry is given. The current status of determination of charge asymmetry for short-lived kaon, obtained by reconstruction of about 10^5 KS -> pen decays collected at DAFNE with the KLOE detector is also reviewed.

  17. Prospects of In-Flight Hyperfine Spectroscopy of (Anti)Hydrogen for Tests of CPT Symmetry

    CERN Document Server

    Widmann, Eberhard

    2016-01-01

    The ground-state hyperfine splitting of antihydrogen promises one of the most sensitive tests of CPT symmetry. The ASACUSA collaboration is pursuing a measurement of this splitting in a Rabi-type experiment using a polarized beam from a CUSP magnet at the Antiproton Decelerator of CERN. With the initial intention of characterizing the Rabi apparatus, a polarized source of cold hydrogen was built and the $\\sigma_1$ transition of hydrogen was measured to a few ppb precision. A measurement of the $\\pi_1$ transition is being prepared. The availability of this beam opens the possibility to perform first measurements of some coefficients within the nonminimal Standard-Model Extension.

  18. Consistency in perturbative calculations and radiatively induced Lorentz and CPT violations

    Energy Technology Data Exchange (ETDEWEB)

    Battistel, O.A. [Department of Physics-CCNE, Universidade Federal de Santa Maria, Santa Maria, RS (Brazil)]. E-mail: orimar@ccne.ufsm.br; Dallabona, G. [Department of Physics-ICEx, Universidade Federal de Minas Gerais, Belo Horizonte (Brazil)]. E-mail: dalla@fisica.ufmg.br

    2002-08-01

    The origin of the radiatively induced Lorentz and CPT violations, in perturbative evaluations, of an extended version of QED, is investigated. Using a very general calculational method, concerning the manipulations and calculations involving divergent amplitudes, we clearly identify the possible sources of contributions for the violating terms. We show that consistency in the perturbative calculations, in a broader sense, leaves no room for the existence of radiatively induced contributions, which is in accordance with what was previously conjectured and recently advocated by some authors supported on general arguments. (author). Letter-to-the-editor.

  19. Ananas comosus L. Leaf Phenols and p-Coumaric Acid Regulate Liver Fat Metabolism by Upregulating CPT-1 Expression

    Directory of Open Access Journals (Sweden)

    Weidong Xie

    2014-01-01

    Full Text Available In this study, we aimed to investigate the effect and action mechanisms of pineapple leaf phenols (PLPs on liver fat metabolism in high-fat diet-fed mice. Results show that PLP significantly reduced abdominal fat and liver lipid accumulation in high-fat diet-fed mice. The effects of PLP were comparable with those of FB. Furthermore, at the protein level, PLP upregulated the expression of carnitine palmitoyltransferase 1 (CPT-1, whereas FB had no effects on CPT-1 compared with the HFD controls. Regarding mRNA expression, PLP mainly promoted the expression of CPT-1, PGC1a, UCP-1, and AMPK in the mitochondria, whereas FB mostly enhanced the expression of Ech1, Acox1, Acaa1, and Ehhadh in peroxisomes. PLP seemed to enhance fat metabolism in the mitochondria, whereas FB mainly exerted the effect in peroxisomes. In addition, p-coumaric acid (CA, one of the main components from PLP, significantly inhibited fat accumulation in oleic acid-induced HepG2 cells. CA also significantly upregulated CPT-1 mRNA and protein expressions in HepG2 cells. We, firstly, found that PLP enhanced liver fat metabolism by upregulating CPT-1 expression in the mitochondria and might be promising in treatment of fatty liver diseases as alternative natural products. CA may be one of the active components of PLP.

  20. Ananas comosus L. Leaf Phenols and p-Coumaric Acid Regulate Liver Fat Metabolism by Upregulating CPT-1 Expression.

    Science.gov (United States)

    Xie, Weidong; Zhang, Shaobo; Lei, Fan; Ouyang, Xiaoxi; Du, Lijun

    2014-01-01

    In this study, we aimed to investigate the effect and action mechanisms of pineapple leaf phenols (PLPs) on liver fat metabolism in high-fat diet-fed mice. Results show that PLP significantly reduced abdominal fat and liver lipid accumulation in high-fat diet-fed mice. The effects of PLP were comparable with those of FB. Furthermore, at the protein level, PLP upregulated the expression of carnitine palmitoyltransferase 1 (CPT-1), whereas FB had no effects on CPT-1 compared with the HFD controls. Regarding mRNA expression, PLP mainly promoted the expression of CPT-1, PGC1a, UCP-1, and AMPK in the mitochondria, whereas FB mostly enhanced the expression of Ech1, Acox1, Acaa1, and Ehhadh in peroxisomes. PLP seemed to enhance fat metabolism in the mitochondria, whereas FB mainly exerted the effect in peroxisomes. In addition, p-coumaric acid (CA), one of the main components from PLP, significantly inhibited fat accumulation in oleic acid-induced HepG2 cells. CA also significantly upregulated CPT-1 mRNA and protein expressions in HepG2 cells. We, firstly, found that PLP enhanced liver fat metabolism by upregulating CPT-1 expression in the mitochondria and might be promising in treatment of fatty liver diseases as alternative natural products. CA may be one of the active components of PLP.

  1. 25 CFR 224.65 - How may a tribe assume additional activities under a TERA?

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false How may a tribe assume additional activities under a TERA... Procedures for Obtaining Tribal Energy Resource Agreements Tera Requirements § 224.65 How may a tribe assume additional activities under a TERA? A tribe may assume additional activities related to the development...

  2. Feynman propagator for the planar version of the CPT-even electrodynamics of Standard Model Extension

    Energy Technology Data Exchange (ETDEWEB)

    Casana, Rodolfo; Ferreira Junior, Manoel M.; Moreira, Roemir P.M. [Universidade Federal do Maranhao (UFMA), MA (Brazil); Gomes, Adalto R. [Instituto Federal de Educacao Ciencia e Tecnologia do Maranhao (IFMA), MA (Brazil)

    2011-07-01

    Full text: In a recent work, we have accomplished the dimensional reduction of the non birefringent CPT-even gauge sector of the Standard Model Extension. As well-known, the CPT-even gauge sector is composed of nineteen components comprised by the fourth-rank tensor, (K{sub F} ){sub μνρσ}, of which nine do not yield birefringence. These nine components can be parametrized in terms of the symmetric and traceless tensor, k{sub μν} = (K{sub F}){sup ρ} νρσ. Starting from this parametrization, and applying the dimensional reduction procedure, we obtain a planar theory corresponding to the non birefringent sector, composed of a gauge and scalar sectors, mutually coupled. These sectors possess six and three independent components, respectively. Some interesting properties of this theory, concerning classical stationary solutions, were examined recently. In the present work, we explicitly evaluate the Feynman propagator for this model, in a tensor closed way, using a set of operators defined in terms of three 3-vectors. We use this propagator to examine the dispersion relations of this theory, and analyze some properties related to its causality, stability, and unitarity. (author)

  3. Feynman propagator for the nonbirefringent CPT-even electrodynamics of the standard model extension

    Science.gov (United States)

    Casana, Rodolfo; Ferreira, Manoel M., Jr.; Gomes, Adalto R.; Dos Santos, Frederico E. P.

    2010-12-01

    The CPT-even gauge sector of the standard model extension is composed of 19 components comprised in the tensor (KF)μνρσ, of which nine do not yield birefringence. In this work, we examine the Maxwell electrodynamics supplemented by these nine nonbirefringent CPT-even components in aspects related to the Feynman propagator and full consistency (stability, causality, unitarity). We adopt a prescription that parametrizes the nonbirefringent components in terms of a symmetric and traceless tensor, Kμν, and second parametrization that writes Kμν in terms of two arbitrary four-vectors, Uμ and Vν. We then explicitly evaluate the gauge propagator of this electrodynamics in a tensor closed way. In the sequel, we show that this propagator and involved dispersion relations can be specialized for the parity-odd and parity-even sectors of the tensor (KF)μνρσ. In this way, we reassess some results of the literature and derive some new outcomes showing that the parity-even anisotropic sector engenders a stable, noncausal and unitary electrodynamics.

  4. Test of CPT and Lorentz symmetry in entangled neutral kaons with the KLOE experiment

    CERN Document Server

    :,; Balwierz-Pytko, I; Bencivenni, G; Bloise, C; Bossi, F; Branchini, P; Budano, A; Balkestahl, L Caldeira; Capon, G; Ceradini, F; Ciambrone, P; Curciarello, F; Czerwinski, E; Danè, E; De Leo, V; De Lucia, E; De Robertis, G; De Santis, A; De Simone, P; Di Cicco, A; Di Domenico, A; Di Donato, C; Di Salvo, R; Domenici, D; Erriquez, O; Fanizzi, G; Fantini, A; Felici, G; Fiore, S; Franzini, P; Gajos, A; Gauzzi, P; Giardina, G; Giovannella, S; Graziani, E; Happacher, F; Heijkenskjold, L; Hoistad, B; Jacewicz, M; Johansson, T; Kacprzak, K; Kaminska, D; Kupsc, A; Lee-Franzini, J; Loddo, F; Loffredo, S; Mandaglio, G; Martemianov, M; Martini, M; Mascolo, M; Messi, R; Miscetti, S; Morello, G; Moricciani, D; Moskal, P; Nguyen, F; Palladino, A; Passeri, A; Patera, V; Longhi, I Prado; Ranieri, A; Santangelo, P; Sarra, I; Schioppa, M; Sciascia, B; Silarski, M; Taccini, C; Tortora, L; Venanzoni, G; Wislicki, W; Wolke, M; Zdebik, J

    2014-01-01

    Neutral kaon pairs produced in phi decays in anti-symmetric entangled state can be exploited to search for violation of CPT symmetry and Lorentz invariance. We present an analysis of the CP-violating process phi->K_S K_L->pi+pi-pi+pi- based on 1.7 fb-1 of data collected by the KLOE experiment at the Frascati phi-factory DAFNE. The data are used to perform a measurement of the CPT-violating parameters Delta_amu for neutral kaons in the contest of the Standard Model Extension framework. The parameters measured in the reference frame of the fixed stars are: Delta_ao = (-6.0 +- 7.7_{stat} +- 3.1_{syst}) x 10^{-18} GeV Delta_ax = ( 0.9 +- 1.5_{stat} +- 0.6_{syst}) x 10^{-18} GeV Delta_ay = (-2.0 +- 1.5_{stat} +- 0.5_{syst}) x 10^{-18} GeV Delta_az = ( 3.1 +- 1.7_{stat} +- 0.5_{syst}) x 10^{-18} GeV These are presently the most precise measurements in the quark sector of the Standard Model Extension.

  5. Precise Measurements of Direct CP Violation, CPT Symmetry, and Other Parameters in the Neutral Kaon System

    CERN Document Server

    Abouzaid, E; Barker, A R; Barrio, M; Bellantoni, L; Blucher, E; Bock, G J; Bown, C; Cheu, E; Coleman, R; Corcoran, M D; Cox, B; Erwin, A R; Escobar, C O; Glazov, A; Golossanov, A; Gomes, R A; Gouffon, P; Graham, J; Hamm, J; Hsiung, Y B; Jensen, D A; Kessler, R; Kotera, K; LaDue, J; Ledovskoy, A; McBride, P L; Monnier, E; Nguyen, H; Niclasen, R; Phillips, D G; Prasad, V; Qi, X R; Ramberg, E J; Ray, R E; Ronquest, M; Roodman, A; Santos, E; Shanahan, P; Shawhan, P S; Slater, W; Smith, D; Solomey, N; Swallow, E C; Taegar, S A; Toale, P A; Tschirhart, R; Wah, Y W; Wang, J; White, H B; Whitmore, J; Wilking, M J; Winstein, B; Winston, R; Worcester, E T; Yamanaka, T; Zimmerman, E D; Zukanovich, R F

    2010-01-01

    We present precise tests of CP and CPT symmetry based on the full dataset of K to pipi decays collected by the KTeV experiment at Fermi National Accelerator Laboratory during 1996, 1997, and 1999. This dataset contains 16 million K to 2pi0 and 69 million K to pi+pi- decays. We measure the direct CP violation parameter Re(epsilon'/epsilon) = (19.2 pm 2.1)x10-4. We find the KL-KS mass difference Deltam = (5270 pm 12)x10^6 hbar/s and the KS lifetime tauS = (89.62 pm 0.05)x10-12 s. We also measure several parameters that test CPT invariance. We find the difference between the phase of the indirect CP violation parameter, epsilon, and the superweak phase, phi epsilon - phiSW = (0.40 pm 0.56) degrees. We measure the difference of the relative phases between the CP violating and CP conserving decay amplitudes for K to pi+pi- (phi+-) and for K to 2pi0 (phi00), Delta phi = (0.30 pm 0.35) degrees. From these phase measurements, we place a limit on the mass difference between K0 and K0bar, DeltaM < 4.8 x 10-19 GeV/c^...

  6. Measurements of Direct CP Violation, CPT Symmetry, and Other Parameters in the Neutral Kaon System

    CERN Document Server

    Alavi-Harati, A

    2003-01-01

    We present a series of measurements based on K -> pi+pi- and K -> pi0pi0 decays collected in 1996-1997 by the KTeV experiment (E832) at Fermilab. We compare these four K -> pipi decay rates to measure the direct CP violation parameter Re(e'/e) = (20.7 +- 2.8) x 10^-4. We also test CPT symmetry by measuring the relative phase between the CP violating and CP conserving decay amplitudes for K->pi+pi- (phi+-) and for K -> pi0pi0 (phi00). We find the difference between the relative phases to be Delta-phi = phi00 - phi+- = (+0.39 +- 0.50) degrees and the deviation of phi+- from the superweak phase to be phi+- - phi_SW =(+0.61 +- 1.19) degrees; both results are consistent with CPT symmetry. In addition, we present new measurements of the KL-KS mass difference and KS lifetime: Delta-m = (5261 +- 15) x 10^6 hbar/s and tauS = (89.65 +- 0.07) x 10^-12 s.

  7. Measurements of Direct CP Violation, CPT Symmetry, and Other Parameters in the Neutral Kaon System

    Energy Technology Data Exchange (ETDEWEB)

    Worcester, Elizabeth Turner [Univ. of Chicago, IL (United States)

    2007-12-01

    The authors present precision measurements of the direct CP violation parameter, Re(ϵ'/ϵ), the kaon parameters, Δm and τS, and the CPT tests, Φ± and ΔΦ, in neutral kaon decays. These results are based on the full dataset collected by the KTeV experiment at Fermi National Accelerator Laboratory during 1996, 1997, and 1999. This dataset contains ~ 15 million K → π0π0 decays and ~ 69 million K → π+π- decays. They describe significant improvements to the precision of these measurements relative to previous KTeV analyses. They find Re(ϵ'/ϵ = [19.2 ± 1.1(stat) ± 1.8(syst)] x 10-4, Δm = (5265 ± 10) x 106 hs-1, and τS = (89.62 ± 0.05) x 10-12 s. They measure Φ± = (44.09 ± 1.00)° and ΔΦ = (0.29 ± 0.31)°; these results are consistent with CPT symmetry.

  8. Dimensional Reduction of a Lorentz- and CPT-violating Chern-Simons Model

    CERN Document Server

    Belich, H; Orlando, M T D

    2003-01-01

    Taking as starting point a Lorentz and CPT non-invariant Chern-Simons-like model defined in 1+3 dimensions, we proceed realizing its dimensional reduction to D=1+2. One then obtains a new planar model, composed by the Maxwell-Chern-Simons (MCS)sector, a Klein-Gordon massless scalar field, and a coupling term that mixes the gauge field to the external vector, $v^{\\mu}$. In spite of breaking Lorentz invariance in the particle frame, this model may preserve the CPT symmetry for a single particular choice of $v^{\\mu}$. The solution of the wave equations shows a behavior similar but which deviates from the usual MCS electrodynamics by some correction-terms (dependent on the background field). These solutions also indicate the existence of spatial-anisotropy in the case $v^{\\mu}$ is purely space-like, which is consistent with the determination of a privileged direction is space, v. The reduced model exhibits stability, but the causality can be jeopardized by some modes. PACS numbers: 11.10.Kk; 11.30.Cp; 11.30.Er; 1...

  9. Effects of a CPT-even and Lorentz-violating nonminimal coupling on electron-positron scattering

    Science.gov (United States)

    Casana, R.; Ferreira, M. M., Jr.; Maluf, R. V.; dos Santos, F. E. P.

    2012-12-01

    We propose a new CPT-even and Lorentz-violating nonminimal coupling between fermions and Abelian gauge fields involving the CPT-even tensor (KF)μναβ of the standard model extension. We thus investigate its effects on the cross section of the electron-positron scattering by analyzing the process e++e-→μ++μ-. Such a study was performed for the parity-odd and parity-even nonbirefringent components of the Lorentz-violating (KF)μναβ tensor. Finally, by using experimental data available in the literature, we have imposed upper bounds as tight as 10-12(eV)-1 on the magnitude of the CPT-even and Lorentz-violating parameters while nonminimally coupled.

  10. A phase II trial of CPT-11 in recurrent squamous carcinoma of the cervix: a gynecologic oncology group study.

    Science.gov (United States)

    Look, K Y; Blessing, J A; Levenback, C; Kohler, M; Chafe, W; Roman, L D

    1998-09-01

    To determine the response rate and associated toxicity of weekly CPT-11 in squamous carcinoma of the cervix. From October 1994 to May 1996, the Gynecologic Oncology Group (GOG) conducted a Phase II trial in patients with recurrent squamous cervix carcinoma. The schedule employed weekly x4 intravenous CPT-11 at 125 mg/m2 followed with a 2-week rest, to be repeated until disease progression or unacceptable toxicity. Eligibility criteria were a GOG performance status of 0-2, adequate bone marrow reserve, adequate liver function, and serum creatinine OFFis schedule of CPT-11 exhibits modest activity with moderate toxicity in patients with recurrent squamous carcinoma of the cervix. Copyright 1998 Academic Press.

  11. Distinct CPT-induced deaths in lung cancer cells caused by clathrin-mediated internalization of CP micelles

    Science.gov (United States)

    Liu, Yu-Sheng; Cheng, Ru-You; Lo, Yu-Lun; Hsu, Chin; Chen, Su-Hwei; Chiu, Chien-Chih; Wang, Li-Fang

    2016-02-01

    We previously synthesized a chondroitin sulfate-graft-poly(ε-caprolactone) copolymer (H-CP) with a high content of poly(ε-caprolactone) (18.7 mol%), which self-assembled in water into a rod-like micelle to encapsulate hydrophobic camptothecin (CPT) in the core (micelle/CPT) for tumor-targeted drug delivery. As a result of the recognition of the micelle by CD44, the micelle/CPT entered CRL-5802 cells efficiently and released CPT efficaciously, resulting in higher tumor suppression than commercial CPT-11. In this study, H1299 cells were found to have a higher CD44 expression than CRL-5802 cells. However, the lower CD44-expressing CRL-5802 cells had a higher percentage of cell death and higher cellular uptake of the micelle/CPT than the higher CD44-expressing H1299 cells. Examination of the internalization pathway of the micelle/CPT in the presence of different endocytic chemical inhibitors showed that the CRL-5802 cells involved clathrin-mediated endocytosis, which was not found in the H1299 cells. Analysis of the cell cycle of the two cell lines exposed to the micelle/CPT revealed that the CRL-5802 cells arrested mainly in the S phase and the H1299 cells arrested mainly in the G2-M phase. A consistent result was also found in the evaluation of γ-H2AX expression, which was about three-fold higher in the CRL-5802 cells than in the H1299 cells. A near-infrared dye, IR780, was encapsulated into the micelle to observe the in vivo biodistribution of the micelle/IR780 in tumor-bearing mice. The CRL-5802 tumor showed a higher fluorescence intensity than the H1299 tumor at any tracing time after 1 h. Thus we tentatively concluded that CRL-5802 cells utilized the clathrin-mediated internalization pathway and arrested in the S phase on exposure to the micelle/CPT; all are possible reasons for the better therapeutic outcome in CRL-5802 cells than in H1299 cells.We previously synthesized a chondroitin sulfate-graft-poly(ε-caprolactone) copolymer (H-CP) with a high content of

  12. Adenoviral vector-mediated expression of a gene encoding secreted, EpCAM-targeted carboxylesterase-2 sensitises colon cancer spheroids to CPT-11

    NARCIS (Netherlands)

    Oosterhoff, D; Overmeer, RM; de Graaf, M; van der Meulen, IH; Giaccone, G; van Beusechem, VW; Haisma, HJ; Pinedo, HM; Gerritsen, WR

    2005-01-01

    CPT-11 (irinotecan or 7-ethyl-10[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin) is an anticancer agent in use for the treatment of colon cancer. In order to be fully active, CPT-11 needs to be converted into SN-38 (7-ethyl-10-hydroxycamptothecin) by the enzyme carboxylesterase (CE). In human

  13. 76 FR 4933 - Environmental Review Procedures for Entities Assuming HUD Environmental Review Responsibilities...

    Science.gov (United States)

    2011-01-27

    ... Responsibilities; Notice of Proposed Information Collection: Comment Request AGENCY: Office of the Assistant...: Environmental Review Procedures for Entities Assuming HUD Environmental Responsibilities. OMB Control...

  14. First Search for Lorentz and CPT Violation in Double Beta Decay with EXO-200

    CERN Document Server

    :,; Barbeau, P S; Beck, D; Belov, V; Breidenbach, M; Brunner, T; Burenkov, A; Cao, G F; Chambers, C; Cleveland, B; Coon, M; Craycraft, A; Daniels, T; Danilov, M; Daugherty, S J; Davis, C G; Davis, J; Delaquis, S; Der Mesrobian-Kabakian, A; DeVoe, R; Díaz, J S; Didberidze, T; Dilling, J; Dolgolenko, A; Dolinski, M J; Dunford, M; Fairbank, W; Farine, J; Feyzbkhsh, S; Feldmeier, W; Fierlinger, P; Fudenberg, D; Gornea, R; Graham, K; Gratta, G; Hall, C; Homiller, S; Hughes, M; Jewell, M J; Jiang, X S; Johnson, A; Johnson, T N; Johnston, S; Karelin, A; Kaufman, L J; Killick, R; Koffas, T; Kravitz, S; Krücken, R; Kuchenkov, A; Kumar, K S; Leonard, D S; Lin, Y H; Ling, J; MacLellan, R; Marino, M G; Mong, B; Moore, D; Nelson, R; Njoya, O; Odian, A; Ostrovskiy, I; Piepke, A; Pocar, A; Prescott, C Y; Retiére, F; Rowson, P C; Russell, J J; Schubert, A; Sinclair, D; Smith, E; Stekhanov, V; Tarka, M; Tolba, T; Tsang, R; Twelker, K; Vuilleumier, J -L; Vogel, P; Waite, A; Walton, J; Walton, T; Weber, M; Wen, L J; Wichoski, U; Wood, J; Yang, L; Yen, Y -R; Zeldovich, O Ya

    2016-01-01

    A search for Lorentz- and CPT-violating signals in the double beta decay spectrum of $^{136}$Xe has been performed using an exposure of 100 kg$\\cdot$yr with the EXO-200 detector. No significant evidence of the spectral modification due to isotropic Lorentz-violation was found, and a two-sided limit of $-2.65 \\times 10^{-5 } \\; \\textrm{GeV} < \\mathring{a}^{(3)}_{\\text{of}} < 7.60 \\times 10^{-6} \\; \\textrm{GeV}$ is placed on the relevant coefficient within the Standard-Model Extension (SME). This is the first experimental study of the effect of the SME-defined oscillation-free and momentum-independent neutrino coupling operator on the double beta decay process.

  15. Constraints on CPT violation from WMAP three year polarization data: a wavelet analysis

    CERN Document Server

    Cabella, Paolo; Silk, Joseph

    2007-01-01

    We perform a wavelet analysis of the temperature and polarization maps of the Cosmic Microwave Background (CMB) delivered by the WMAP experiment in search for a parity violating signal. Such a signal could be seeded by new physics beyond the standard model, for which the Lorentz and CPT symmetries may not hold. Under these circumstances, the linear polarization direction of a CMB photon may get rotated during its cosmological journey, a phenomenon also called cosmological birefringence. Recently, Feng et al. have analyzed a subset the WMAP and BOOMERanG 2003 angular power spectra of the CMB, deriving a constraint that mildly favors a non zero rotation. By using wavelet transforms we set a tighter limit on the CMB photon rotation angle \\Delta\\alpha= -2.5 \\pm 3.0 (\\Delta\\alpha= -2.5 \\pm 6.0) at the one (two) \\sigma level, consistent with a null detection.

  16. Information-Entropic for Travelling Solitons in Lorentz and CPT Breaking Systems

    CERN Document Server

    Correa, R A C; Dutra, A de Souza

    2015-01-01

    In this work we group three research topics apparently disconnected, namely solitons, Lorentz symmetry breaking and entropy. Following a recent work [Phys. Lett. B 713 (2012) 304], we show that it is possible to construct in the context of travelling wave solutions a configurational entropy measure in functional space, from the field configurations. Thus, we investigate the existence and properties of travelling solitons in Lorentz and CPT breaking scenarios for a class of models with two interacting scalar fields. Here, we obtain a complete set of exact solutions for the model studied which display both double and single-kink configurations. In fact, such models are very important in applications that include Bloch branes, Skyrmions, Yang-Mills, Q-balls, oscillons and various superstring-motivated theories. We find that the so-called Configurational Entropy (CE) for travelling solitons, which we name as travelling Configurational Entropy (TCE), shows that the best value of parameter responsible to break the ...

  17. CPT site characterization for seismic hazards in the New Madrid seismic zone

    Science.gov (United States)

    Liao, T.; Mayne, P.W.; Tuttle, M.P.; Schweig, E.S.; Van Arsdale, R.B.

    2002-01-01

    A series of cone penetration tests (CPTs) were conducted in the vicinity of the New Madrid seismic zone in central USA for quantifying seismic hazards, obtaining geotechnical soil properties, and conducting studies at liquefaction sites related to the 1811-1812 and prehistoric New Madrid earthquakes. The seismic piezocone provides four independent measurements for delineating the stratigraphy, liquefaction potential, and site amplification parameters. At the same location, two independent assessments of soil liquefaction susceptibility can be made using both the normalized tip resistance (qc1N) and shear wave velocity (Vs1). In lieu of traditional deterministic approaches, the CPT data can be processed using probability curves to assess the level and likelihood of future liquefaction occurrence. ?? 2002 Elsevier Science Ltd. All rights reserved.

  18. A unified classification model for modeling of seismic liquefaction potential of soil based on CPT.

    Science.gov (United States)

    Samui, Pijush; Hariharan, R

    2015-07-01

    The evaluation of liquefaction potential of soil due to an earthquake is an important step in geosciences. This article examines the capability of Minimax Probability Machine (MPM) for the prediction of seismic liquefaction potential of soil based on the Cone Penetration Test (CPT) data. The dataset has been taken from Chi-Chi earthquake. MPM is developed based on the use of hyperplanes. It has been adopted as a classification tool. This article uses two models (MODEL I and MODEL II). MODEL I employs Cone Resistance (q c) and Cyclic Stress Ratio (CSR) as input variables. q c and Peak Ground Acceleration (PGA) have been taken as inputs for MODEL II. The developed MPM gives 100% accuracy. The results show that the developed MPM can predict liquefaction potential of soil based on q c and PGA.

  19. Nonorthogonality and κ-Dependence Eccentricity of Polarized Electromagnetic Waves in CPT-Even Lorentz Violation

    Directory of Open Access Journals (Sweden)

    Thiago Prudêncio

    2017-01-01

    Full Text Available We discuss the modified Maxwell action of a KF-type Lorentz symmetry breaking theory and present a solution of Maxwell equations derived in the cases of linear and elliptically polarized electromagnetic waves in the vacuum of CPT-even Lorentz violation. We show in this case that the Lorentz violation has the effect of changing the amplitude of one component of the magnetic field, while leaving the electric field unchanged, leading to nonorthogonal propagation of electromagnetic fields and dependence of the eccentricity on κ-term. Further, we exhibit numerically the consequences of this effect in the cases of linear and elliptical polarization, in particular, the regimes of nonorthogonality of the electromagnetic wave fields and the eccentricity of the elliptical polarization of the magnetic field with dependence on the κ-term.

  20. Maxwell-Chern-Simons vortices in a CPT-odd Lorentz-violating Higgs Electrodynamics

    CERN Document Server

    Casana, R; da Hora, E; Neves, A B F

    2014-01-01

    We have studied BPS vortices in a CPT-odd and Lorentz-violating Maxwell-Chern-Simons-Higgs (MCSH) electrodynamics attained from the dimensional reduction of the Carroll-Field-Jackiw-Higgs model. The Lorentz-violating parameter induces a pronounced behavior at origin (for the magnetic/electric fields and energy density) which is absent in the MCSH vortices. For some combination of the Lorentz-violating coefficients there always exist a sufficiently large winding number $n_{0}$ such that for all $% |n|\\geq |n_{0}|$ the magnetic field flips its signal, yielding two well defined regions with opposite magnetic flux. However, the total magnetic flux remains quantized and proportional to the winding number.

  1. Gauge propagator and physical consistency of the CPT-even part of the Standard Model Extension

    CERN Document Server

    Casana, Rodolfo; Gomes, Adalto R; Pinheiro, Paulo R D

    2009-01-01

    In this work, we explicitly evaluate the gauge propagator of the Maxwell theory supplemented by the CPT-even term of the SME. We begin evaluating the propagator of the parity-odd sector as $4\\times 4$ matrix using a parametrization that retains only three parity-odd coefficients. Starting from the poles of the propagator, it is shown that this electrodynamics is stable, non-causal and unitary. In the sequel, we carry out the parity-even gauge propagator as $4\\times 4$ matrix working with only the isotropic non-birefringent element. In this case, we show that the parity-even sector of the tensor $W$ is causal, stable and unitary.

  2. Uncharged vortex solutions in a CPT-even Lorentz-violating electrodynamics

    CERN Document Server

    Casana, R; da Hora, E; Cantanhede, C M

    2011-01-01

    In this work, we investigate the existence stable uncharged vortex solutions in the framework of the Lorentz-breaking and CPT-even electrodynamics of the Standard Model Extension in the presence of the Higgs sector endowed with a fourth order self-interacting potential. We verify the possibility of attaining uncharged non-BPS and BPS solutions in this LIV environment, whose profiles are obtained numerically. It is observed that the Lorentz-violating parameter alters the radial extension of the defect (core of the solution) and the amplitude of the magnetic field, a result also observed in k-field defects. This new result opens the possibility of controlling the extension of the defect without altering neither the Higgs potential nor the kinetic sector of the theory.

  3. Maxwell-Chern-Simons vortices in a CPT-odd Lorentz-violating Higgs electrodynamics

    Energy Technology Data Exchange (ETDEWEB)

    Casana, R.; Ferreira, M.M.; Hora, E. da; Neves, A.B.F. [Universidade Federal do Maranhao, Departamento de Fisica, Sao Luis, Maranhao (Brazil)

    2014-09-15

    We study BPS vortices in a CPT-odd and Lorentz-violating Maxwell-Chern-Simons-Higgs (MCSH) electrodynamics attained from the dimensional reduction of the Carroll-Field-Jackiw-Higgs model. The Lorentz-violating parameter induces a pronounced behavior at origin (for the magnetic/electric fields and energy density) which is absent in the MCSH vortices. For some combination of the Lorentz-violating coefficients there always exists a sufficiently large winding number n{sub 0} such that for all vertical stroke n vertical stroke ≥ vertical stroke n{sub 0} vertical stroke the magnetic field flips sign, yielding two well-defined regions with opposite magnetic flux. However, the total magnetic flux remains quantized and proportional to the winding number. (orig.)

  4. Maxwell-Chern-Simons vortices in a CPT-odd Lorentz-violating Higgs electrodynamics

    Science.gov (United States)

    Casana, R.; Ferreira, M. M.; da Hora, E.; Neves, A. B. F.

    2014-09-01

    We have studied BPS vortices in a CPT-odd and Lorentz-violating Maxwell-Chern-Simons-Higgs (MCSH) electrodynamics attained from the dimensional reduction of the Carroll-Field-Jackiw-Higgs model. The Lorentz-violating parameter induces a pronounced behavior at origin (for the magnetic/electric fields and energy density) which is absent in the MCSH vortices. For some combination of the Lorentz-violating coefficients there always exist a sufficiently large winding number $n_{0}$ such that for all $% |n|\\geq |n_{0}|$ the magnetic field flips its signal, yielding two well defined regions with opposite magnetic flux. However, the total magnetic flux remains quantized and proportional to the winding number.

  5. Gauge propagator and physical consistency of the CPT-even part of the standard model extension

    Science.gov (United States)

    Casana, Rodolfo; Ferreira, Manoel M., Jr.; Gomes, Adalto R.; Pinheiro, Paulo R. D.

    2009-12-01

    In this work, we explicitly evaluate the gauge propagator of the Maxwell theory supplemented by the CPT-even term of the standard model extension. First, we specialize our evaluation for the parity-odd sector of the tensor Wμνρσ, using a parametrization that retains only the three nonbirefringent coefficients. From the poles of the propagator, it is shown that physical modes of this electrodynamics are stable, noncausal and unitary. In the sequel, we carry out the parity-even gauge propagator using a parametrization that allows to work with only the isotropic nonbirefringent element. In this case, we show that the physical modes of the parity-even sector of the tensor W are causal, stable and unitary for a limited range of the isotropic coefficient.

  6. First Search for Lorentz and CPT Violation in Double Beta Decay with EXO-200

    CERN Document Server

    Kaufman, L J

    2016-01-01

    This proceedings contribution reports the first experimental search for Lorentz- and CPT-violating signals specifically studying the effect of the Standard-Model Extension (SME) oscillation-free momentum-independent neutrino coupling operator in the double beta decay process. The search has been performed using an exposure of 100 kg yr of $^{136}$Xe with the EXO-200 detector. No significant evidence of the spectral modification due to isotropic Lorentz violation was found. A two-sided limit of $-2.65 \\times 10^{-5}$ GeV $<$ $\\mathring{a}_{\\mathrm{of}}^{(3)}$ $< 7.60 \\times 10^{-6}$ GeV (90% C.L.) is placed on the relevant coefficient within the SME.

  7. CPT coding patterns at nurse-managed health centers: data from a national survey.

    Science.gov (United States)

    Vonderheid, Susan C; Pohl, Joanne M; Tanner, Clare; Newland, Jamesetta A; Gans, Dave N

    2009-01-01

    Nurse-managed health centers (NMHCs) play an important role in delivering health care services to a wide range of communities and often serve as our nation's safety net providers. Unfortunately, NMHCs struggle to remain in business for a variety of reasons, including underdeveloped business practices. Until now, NMHCs had only data from the Centers for Medicare and Medicaid Services and the Medical Group Management Assocation for comparison with coding patterns in individual centers. This article is the first published report of national data for NMHCs that is available for comparison. Providers need to possess financial acumen to remain open for business. Assessment of CPT coding patterns is a key strategy to support long-term sustainability.

  8. CPT violation in entangled B0-B0bar states and the demise of flavour tagging

    CERN Document Server

    Alvarez, E; Mavromatos, Nikolaos E; Nebot, M; Papavassiliou, J

    2004-01-01

    We discuss the demise of flavour tagging due to the loss of the particle-antiparticle identity of neutral B-mesons in the Einstein-Podolsky-Rosen correlated states. Such a situation occurs in cases where the CPT operator is ill-defined, as happens, for example, in quantum gravity models with induced decoherence in the matter sector. The time evolution of the perturbed B0-B0bar initial state, as produced in B-factories, is sufficient to generate new two-body states. For flavour specific decays at equal times, we discuss two definite tests of the two body entanglement: (i) search for the would-be forbidden B0 B0 and B0bar B0bar states; (ii) deviations from the indistinguishable probability between the permuted states B0bar B0 and B0 B0bar.

  9. Vibrio cholerae bacteriophage CP-T1: characterization of bacteriophage DNA and restriction analysis.

    Science.gov (United States)

    Guidolin, A; Morelli, G; Kamke, M; Manning, P A

    1984-01-01

    Temperature bacteriophage CP-T1 of Vibrio cholerae has a capsid that is 45 nm in diameter, a contractile tail 65 nm long and 9.5 nm wide, and a baseplate with several spikes or short tail fibers. The linear double-stranded DNA is 43.5 +/- 1.4 kilobases long, and the phage genome is both terminally redundant and partially circularly permuted. The extent of terminal redundancy is ca. 4%, and circular permutation is up to ca. 44%. Circular restriction maps have been constructed for the enzymes HindIII, EcoRI, BamHI, and PstI. By restriction endonuclease and heteroduplex analyses of phage DNA, the presence and location of a site (pac) at which packaging of phage DNA is initiated was established. Images PMID:6328035

  10. Vibrio cholerae bacteriophage CP-T1: characterization of bacteriophage DNA and restriction analysis.

    Science.gov (United States)

    Guidolin, A; Morelli, G; Kamke, M; Manning, P A

    1984-07-01

    Temperature bacteriophage CP-T1 of Vibrio cholerae has a capsid that is 45 nm in diameter, a contractile tail 65 nm long and 9.5 nm wide, and a baseplate with several spikes or short tail fibers. The linear double-stranded DNA is 43.5 +/- 1.4 kilobases long, and the phage genome is both terminally redundant and partially circularly permuted. The extent of terminal redundancy is ca. 4%, and circular permutation is up to ca. 44%. Circular restriction maps have been constructed for the enzymes HindIII, EcoRI, BamHI, and PstI. By restriction endonuclease and heteroduplex analyses of phage DNA, the presence and location of a site (pac) at which packaging of phage DNA is initiated was established.

  11. IMPROVED DOWN-HOLE CPT TOOLS FOR THE DETECTION OF CHLORINATED SOLVENTS

    Energy Technology Data Exchange (ETDEWEB)

    Martin L. Gildea; Stephen P. Farrington, P.E.; Wesley L. Bratton, Ph.D., PE

    1998-09-01

    Conventional soil and groundwater sampling procedures present many opportunities for loss of volatile organic compounds (VOC) by exposing sample media to the atmosphere during transfers between sampling devices and containers, ultimately affecting the quality of the analytical results. Inaccurate characterization data often leads to improperly designed remedial systems that slow the clean-up process and increase the cost. For these reasons, in situ methods for sample extraction and real time analysis provide attractive alternatives to conventional sampling and analysis. Under funding from the U.S. Department of Energy's Federal Energy Technology Center (FETC), the investigators continued development of a system that combines High Speed Gas Chromatography techniques with Cone Penetration Testing to achieve near-real time analysis of soils and groundwater for chlorinated and aromatic hydrocarbon contamination (PCE, TCE, BTEX) during site characterization. The system combines three new CPT tools with an up-hole analyzer. The Dynamic Thermal Desorption (DTD) probe provides the up-hole analyzer with continuously sampled soil gas, enhancing detection limits by heating the soil matrix during penetration to thermally desorb volatile organic contaminants. The CPT In Situ Purge Probe (CISP) purges a water sample in situ, transferring the purge gas up-hole for analysis. Alternatively, soil gas or purge gas from the DTD probe or the CISP can be diverted to a Downhole Trap Module (DTM), which traps contaminants on conventional trap media for later analysis in a fixed laboratory. While the effectiveness of the CISP was hampered by the tendency of fine grained materials to clog its sample inlet filter, the DTD probe and the DTM were demonstrated to perform their intended functions well.

  12. Genuine T, CP, CPT asymmetry parameters for the entangled B d system

    Science.gov (United States)

    Bernabéu, José; Botella, Francisco J.; Nebot, Miguel

    2016-06-01

    The precise connection between the theoretical T, CP, CPT asymmetries, in terms of transition probabilities between the filtered neutral meson B d states, and the experimental asymmetries, in terms of the double decay rate intensities for Flavour-CP eigenstate decay products in a B-factory of entangled states, is established. This allows the identification of genuine Asymmetry Parameters in the time distribution of the asymmetries and their measurability by disentangling genuine and possible fake terms. We express the nine asymmetry parameters — three different observables for each one of the three symmetries — in terms of the ingredients of the Weisskopf-Wigner dynamical description of the entangled B d -meson states and we obtain a global fit to their values from the BaBar collaboration experimental results. The possible fake terms are all compatible with zero and the information content of the nine asymmetry parameters is indeed different. The non-vanishing [InlineMediaObject not available: see fulltext.] and [InlineMediaObject not available: see fulltext.] are impressive separate direct evidence of Time-Reversal-violation and CP-violation in these transitions and compatible with Standard Model expectations. An intriguing 2 σ effect for the Re( θ) parameter responsible of CPT-violation appears which, interpreted as an upper limit, leads to |{M}_{{overline{B}}^0{overline{B}}^0}-{M}_B{{{}{^0}}_B}{^0}|<4.0× 1{0}^{-5} eV at 95% C.L. for the diagonal flavour terms of the mass matrix. It contributes to the CP-violating [InlineMediaObject not available: see fulltext.] asymmetry parameter in an unorthodox manner — in its cos(Δ M t) time dependence —, and it is accessible in facilities with non-entangled B d 's, like the LHCb experiment.

  13. Effects of Antidepressants on DSP4/CPT-Induced DNA Damage Response in Neuroblastoma SH-SY5Y Cells.

    Science.gov (United States)

    Wang, Yan; Hilton, Benjamin A; Cui, Kui; Zhu, Meng-Yang

    2015-08-01

    DNA damage is a form of cell stress and injury. Increased systemic DNA damage is related to the pathogenic development of neurodegenerative diseases. Depression occurs in a relatively high percentage of patients suffering from degenerative diseases, for whom antidepressants are often used to relieve depressive symptoms. However, few studies have attempted to elucidate why different groups of antidepressants have similar effects on relieving symptoms of depression. Previously, we demonstrated that neurotoxins N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP4)- and camptothecin (CPT) induced the DNA damage response in SH-SY5Y cells, and DSP4 caused cell cycle arrest which was predominately in the S-phase. The present study shows that CPT treatment also resulted in similar cell cycle arrest. Some classic antidepressants could reduce the DNA damage response induced by DSP4 or CPT in SH-SY5Y cells. Cell viability examination demonstrated that both DSP4 and CPT caused cell death, which was prevented by spontaneous administration of some tested antidepressants. Flow cytometric analysis demonstrated that a majority of the tested antidepressants protect cells from being arrested in S-phase. These results suggest that blocking the DNA damage response may be an important pharmacologic characteristic of antidepressants. Exploring the underlying mechanisms may allow for advances in the effort to improve therapeutic strategies for depression appearing in degenerative and psychiatric diseases.

  14. Limit on lorentz and CPT violation of the neutron using a two-species noble-Gas maser

    Science.gov (United States)

    Bear; Stoner; Walsworth; Kostelecky; Lane

    2000-12-11

    A search for sidereal variations in the frequency difference between co-located 129Xe and 3He Zeeman masers sets the most stringent limit to date on leading-order Lorentz and CPT violation involving the neutron, consistent with no effect at the level of 10(-31) GeV.

  15. Ambiguities of the CPT-even aether-like Lorentz-breaking term at the finite temperature

    CERN Document Server

    Mariz, T; Petrov, A Yu; Serafim, W

    2014-01-01

    In this paper, we consider the finite temperature behaviour of the CPT-even aether-like Lorentz-breaking term in the extended Lorentz-breaking QED and demonstrate that its ambiguities whose presence has been shown earlier in the zero temperature case stay also at the finite temperature.

  16. MBL-II-141, a chromone derivative, enhances irinotecan (CPT-11) anticancer efficiency in ABCG2-positive xenografts

    Science.gov (United States)

    Honorat, Mylène; Guitton, Jérôme; Gauthier, Charlotte; Bouard, Charlotte; Lecerf-Schmidt, Florine; Peres, Basile; Terreux, Raphaël; Gervot, Héloïse; Rioufol, Catherine; Boumendjel, Ahcène; Puisieux, Alain; Di Pietro, Attilio; Payen, Léa

    2014-01-01

    ABCG2 is responsible for the multidrug resistance (MDR) phenotype, and strongly modulates cancer outcomes. Its high expression at a number of physiological barriers, including blood-brain and intestinal barriers, impacts on drug pharmacokinetics parameters. We characterized MBL-II-141, a specific and potent ABCG2 inhibitor. Combination of 10 mg/kg MBL-II-141 with the anticancer agent CPT-11 completely blocked the growth of 90% freshly implanted ABCG2-positive tumors. Moreover, the same combination slowed the growth of already established tumors. As required for preclinical development, we defined the main pharmacokinetics parameters of MBL-II-141 and its influence on the kinetics of CPT-11 and its active metabolite SN-38 in mice. MBL-II-141 distribution into the brain occurred at a low, but detectable, level. Interestingly, preliminary data suggested that MBL-II-141 is well tolerated (at 50 mg/kg) and absorbed upon force-feeding. MBL-II-141 induced a potent sensitization of ABCG2-positive xenografts to CPT-11 through in vivo ABCG2 inhibition. MBL-II-141 strongly increased CPT-11 levels in the brain, and therefore would be a valuable agent to improve drug distribution into the brain to efficiently treat aggressive gliomas. Safety and other pharmacological data strongly support the reglementary preclinical development of MBL-II-141. PMID:25474134

  17. Exploration of CPT violation via time-dependent geometric quantities embedded in neutrino oscillation through fluctuating matter

    Science.gov (United States)

    Wang, Zisheng; Pan, Hui

    2017-02-01

    We propose a new approach to explore CPT violation of neutrino oscillations through a fluctuating matter based on time-dependent geometric quantities. By mapping the neutrino oscillations onto a Poincaré sphere structure, we obtain an analytic solution of master equation and further define the geometric quantities, i.e., radius of Poincaré sphere and geometric phase. We find that the mixing process between electron and muon neutrinos can be described by the radius of Poincaré sphere that depends on the intrinsic CP-violating angle. Such a radius reveals a dynamic mechanism of CPT-violation, i.e., both spontaneous symmetry breaking and Majorana-Dirac neutrino confusion. We show that the time-dependent geometric phase can be used to find the neutrino nature and observe the CPT-violation because it is strongly enhanced under the neutrino propagation. We further show that the time-dependent geometric phase can be easily detected by simulating the neutrino oscillation based on fluctuating magnetic fields in nuclear magnetic resonance, which makes the experimental observation of CPT-violation possible in the neutrino mixing and oscillations.

  18. Convection-enhanced delivery of nanoliposomal CPT-11 (irinotecan) and PEGylated liposomal doxorubicin (Doxil) in rodent intracranial brain tumor xenografts.

    Science.gov (United States)

    Krauze, Michal T; Noble, Charles O; Kawaguchi, Tomohiro; Drummond, Daryl; Kirpotin, Dmitri B; Yamashita, Yoji; Kullberg, Erika; Forsayeth, John; Park, John W; Bankiewicz, Krystof S

    2007-10-01

    We have previously shown that convection-enhanced delivery (CED) of highly stable nanoparticle/liposome agents encapsulating chemotherapeutic drugs is effective against intracranial rodent brain tumor xenografts. In this study, we have evaluated the combination of a newly developed nanoparticle/liposome containing the topoisomerase I inhibitor CPT-11 (nanoliposomal CPT-11 [nLs-CPT-11]), and PEGylated liposomal doxorubicin (Doxil) containing the topoisomerase II inhibitor doxorubicin. Both drugs were detectable in the CNS for more than 36 days after a single CED application. Tissue half-life was 16.7 days for nLs-CPT-11 and 10.9 days for Doxil. The combination of the two agents produced synergistic cytotoxicity in vitro. In vivo in U251MG and U87MG intracranial rodent xenograft models, CED of the combination was also more efficacious than either agent used singly. Analysis of the parameters involved in this approach indicated that tissue pharmacokinetics, tumor microanatomy, and biochemical interactions of the drugs all contributed to the therapeutic efficacy observed. These findings have implications for further clinical applications of CED-based treatment of brain tumors.

  19. Pre-Service Teachers' Personal Epistemic Beliefs and the Beliefs They Assume Their Pupils to Have

    Science.gov (United States)

    Rebmann, Karin; Schloemer, Tobias; Berding, Florian; Luttenberger, Silke; Paechter, Manuela

    2015-01-01

    In their workaday life, teachers are faced with multiple complex tasks. How they carry out these tasks is also influenced by their epistemic beliefs and the beliefs they assume their pupils hold. In an empirical study, pre-service teachers' epistemic beliefs and those they assume of their pupils were investigated in the setting of teacher…

  20. 复方斑蝥胶囊联合CPT-11+CF+5Fu治疗晚期大肠癌的临床观察%Comparative study on treatment of advanced colorectal cancer by Banmao capsule combined with CPT-11+CF+5Fu regimen and by CPT-11+CF+5Fu regimen alone

    Institute of Scientific and Technical Information of China (English)

    林燕; 陆明

    2011-01-01

    Objective To evaluate the therapeutic efficacy and adverse reaction of Banmao capsule combined with CPT-11+CF+5Fu regimen for treatment of patients with advanced colorectal cancer and controlled with those of CPT-11 + CF+5Fu regimen alone. Methods 87 patients were randomly devided into two groups. All the patients received CPT-11 + CF+5Fu regimen,I , e. CPT-11 150-180 mg/m2 intravenous dropping in on day 1,C F 200 mg/m2 intravenous dropping and 5-FU 40 mg/m2 intravenous injection followed with 600 mg/m2 continuous infusion by micro-pump in 22 h on day 1 and 2,14 days as one course. Besides,to the treatment group (47 patients ), Banmao capsules was PO for 15 successive days,while to the control group(40 patients),no additional medication was given. Results The response rate in the treatment group was 44. 81% and in the control group 33. 6% (P = 0. 3355). The KPS score improving rate in the two groups was 65. 96% and 40%, respectively (P<0. 005). The lyear survival rate was 53. 19% and 40. 38% , respectively (P=0. 2193),and the adverse reaction presented in the treatment group was greatly less than that in the control group (P<0. 05). Conclusion Banmao capsules in combining with CPT-11+CF+5Fu regimen can enhance the efficacy, reduce the adverse reaction of chemotherapy in treating advanced colorectal cancer, and could also improve the quality of life and prolong the survival time of patients.%目的 观察复方斑蝥胶囊联合CPT-11+CF+5Fu化疗治疗晚期大肠癌的近期疗效和不良反应,方法将87例大肠癌患者随机分两组,对照组40例,单用CPT-11+CF+5Fu化疗方案,用法:CPT-11150~180 mg/m2,第1、8天,亚叶酸钙200 mg/m2静脉滴注2h,第1、2天,5-氟脲嘧啶300mg/m2静脉推注,第1、2天,600mg/m2持续微泵推入22 h,第1、2天,21天为1个周期;治疗组47例,在对照组治疗基础上加用复方斑蝥胶囊0.75 g,2次/日,连用15天.结果 治疗组和对照组有效率分别是44.81%和33.6%,差异无显著性(P=0

  1. A Concept Analysis: Assuming Responsibility for Self-Care among Adolescents with Type 1 Diabetes

    Science.gov (United States)

    Hanna, Kathleen M.; Decker, Carol L.

    2009-01-01

    Purpose This concept analysis clarifies “assuming responsibility for self-care” by adolescents with type 1 diabetes. Methods Walker and Avant’s (2005) methodology guided the analysis. Results Assuming responsibility for self-care was defined as a process specific to diabetes within the context of development. It is daily, gradual, individualized to person, and unique to task. The goal is ownership that involves autonomy in behaviors and decision-making. Practice Implications Adolescents with type 1 diabetes need to be assessed for assuming responsibility for self-care. This achievement has implications for adolescents’ diabetes management, short- and long-term health, and psychosocial quality of life. PMID:20367781

  2. The CPT1C 5'UTR contains a repressing upstream open reading frame that is regulated by cellular energy availability and AMPK.

    Directory of Open Access Journals (Sweden)

    Ines Lohse

    Full Text Available BACKGROUND: Translational control is utilized as a means of regulating gene expression in many species. In most cases, posttranscriptional regulatory mechanisms play an important role in stress response pathways and can lead to dysfunctional physiology if blocked by mutations. Carnitine Palmitoyltransferase 1 C (CPT1C, the brain-specific member of the CPT 1 family, has previously been shown to be involved in regulating metabolism in situations of energy surplus. PRINCIPAL FINDINGS: Sequence analysis of the CPT1C mRNA revealed that it contains an upstream open reading frame (uORF in the 5' UTR of its mRNA. Using CPT1C 5' UTR/luciferase constructs, we investigated the role of the uORF in translational regulation. The results presented here show that translation from the CPT1C main open reading frame (mORF is repressed by the presence of the uORF, that this repression is relieved in response to specific stress stimuli, namely glucose deprivation and palmitate-BSA treatment, and that AMPK inhibition can relieve this uORF-dependent repression. SIGNIFICANCE: The fact that the mORF regulation is relieved in response to a specific set of stress stimuli rather than general stress response, hints at an involvement of CPT1C in cellular energy-sensing pathways and provides further evidence for a role of CPT1C in hypothalamic regulation of energy homeostasis.

  3. Genuine T, CP, CPT asymmetry parameters for the entangled B{sub d} system

    Energy Technology Data Exchange (ETDEWEB)

    Bernabéu, José; Botella, Francisco J.; Nebot, Miguel [Departament de Fśica Teòrica & IFIC, Universitat de València & CSIC,E-46100, València (Spain)

    2016-06-17

    The precise connection between the theoretical T, CP, CPT asymmetries, in terms of transition probabilities between the filtered neutral meson B{sub d} states, and the experimental asymmetries, in terms of the double decay rate intensities for Flavour-CP eigenstate decay products in a B-factory of entangled states, is established. This allows the identification of genuine Asymmetry Parameters in the time distribution of the asymmetries and their measurability by disentangling genuine and possible fake terms. We express the nine asymmetry parameters — three different observables for each one of the three symmetries — in terms of the ingredients of the Weisskopf-Wigner dynamical description of the entangled B{sub d}-meson states and we obtain a global fit to their values from the BaBar collaboration experimental results. The possible fake terms are all compatible with zero and the information content of the nine asymmetry parameters is indeed different. The non-vanishing ΔS{sub c}{sup T}=−0.687±0.020 and ΔS{sub c}{sup CP}=−0.680±0.021 are impressive separate direct evidence of Time-Reversal-violation and CP-violation in these transitions and compatible with Standard Model expectations. An intriguing 2σ effect for the Re(θ) parameter responsible of CPT-violation appears which, interpreted as an upper limit, leads to |M{sub B̄{sup 0}B̄{sup 0}}−M{sub B{sup 0}B{sup 0}}|<4.0×10{sup −5} eV at 95% C.L. for the diagonal flavour terms of the mass matrix. It contributes to the CP-violating ΔC{sub c}{sup CP} asymmetry parameter in an unorthodox manner — in its cos (ΔM t) time dependence —, and it is accessible in facilities with non-entangled B{sub d}’s, like the LHCb experiment.

  4. Preparing for Upheaval in North Korea: Assuming North Korean Regime Collapse

    Science.gov (United States)

    2013-12-01

    defense agreement between North Korea and China but also pro-Chinese North Korean elites’ requests for Chinese help are likely to justify Chinese...PREPARING FOR UPHEAVAL IN NORTH KOREA : ASSUMING NORTH KOREAN REGIME COLLAPSE by Kwonwoo Kim December 2013 Thesis Advisor: Wade Huntley Second...REPORT TYPE AND DATES COVERED Master’s Thesis 4. TITLE AND SUBTITLE PREPARING FOR UPHEAVAL IN NORTH KOREA : ASSUMING NORTH KOREAN REGIME COLLAPSE 5

  5. First observation of quantum interference in the process phi -> KS KL ->pi+pi-pi+pi-: a test of quantum mechanics and CPT symmetry

    CERN Document Server

    Ambrosino, F; Antonelli, M; Bacci, C; Beltrame, P; Bencivenni, G; Bertolucci, S; Bini, C; Bloise, C; Bocchetta, S; Bocci, V; Bossi, F; Bowring, D; Branchini, P; Caloi, R; Campana, P; Capon, G; Capussela, T; Ceradini, F; Chi, S; Chiefari, G; Ciambrone, P; Conetti, S; De Lucia, E; De Santis, A; De Simone, P; De Zorzi, G; Dell'Agnello, S; Denig, A; Di Domenico, A; Di Donato, C; Di Falco, S; Di Micco, B; Doria, A; Dreucci, M; Felici, G; Ferrari, A; Ferrer, M L; Finocchiaro, G; Fiore, S; Forti, C; Franzini, P; Gatti, C; Gauzzi, P; Giovannella, S; Gorini, E; Graziani, E; Incagli, M; Kluge, W; Kulikov, V; Lacava, F; Lanfranchi, G; Lee-Franzini, J; Leone, D; Martini, M; Massarotti, P; Mei, W; Meola, S; Miscetti, S; Moulson, M; Müller, S; Murtas, F; Napolitano, M; Nguyen, F; Palutan, M; Pasqualucci, E; Passeri, A; Patera, V; Perfetto, F; Pontecorvo, L; Primavera, M; Santangelo, P; Santovetti, E; Saracino, G; Sciascia, B; Sciubba, A; Scuri, F; Sfiligoi, I; Sibidanov, A L; Spadaro, T; Testa, M; Tortora, L; Valente, P; Valeriani, B; Venanzoni, G; Veneziano, Stefano; Ventura, A; Versaci, R; Xu, G

    2006-01-01

    We present the first observation of quantum interference in the process phi -> KS KL ->pi+pi-pi+pi-. This analysis is based on data collected with the KLOE detector at the e^+e^- collider DAFNE in 2001--2002 for an integrated luminosity of about 380pb^-1. Fits to the distribution of Delta t, the difference between the two kaon decay times, allow tests of the validity of quantum mechanics and CPT symmetry. No deviations from the expectations of quantum mechanics and CPT symmetry have been observed. New or improved limits on various decoherence and CPT violation parameters have been obtained

  6. A selective sweep on a deleterious mutation in CPT1A in Arctic populations

    KAUST Repository

    Clemente, Florian J.

    2014-11-01

    Arctic populations live in an environment characterized by extreme cold and the absence of plant foods for much of the year and are likely to have undergone genetic adaptations to these environmental conditions in the time they have been living there. Genome-wide selection scans based on genotype data from native Siberians have previously highlighted a 3 Mb chromosome 11 region containing 79 protein-coding genes as the strongest candidates for positive selection in Northeast Siberians. However, it was not possible to determine which of the genes might be driving the selection signal. Here, using whole-genome high-coverage sequence data, we identified the most likely causative variant as a nonsynonymous G>A transition (rs80356779; c.1436C>T [p.Pro479Leu] on the reverse strand) in CPT1A, a key regulator of mitochondrial long-chain fatty-acid oxidation. Remarkably, the derived allele is associated with hypoketotic hypoglycemia and high infant mortality yet occurs at high frequency in Canadian and Greenland Inuits and was also found at 68% frequency in our Northeast Siberian sample. We provide evidence of one of the strongest selective sweeps reported in humans; this sweep has driven this variant to high frequency in circum-Arctic populations within the last 6-23 ka despite associated deleterious consequences, possibly as a result of the selective advantage it originally provided to either a high-fat diet or a cold environment.

  7. CPT Profiling and Laboratory Data Correlations for Deriving of Selected Geotechnical Parameter

    Science.gov (United States)

    Bulko, Roman; Drusa, Marián; Vlček, Jozef; Mečár, Martin

    2015-12-01

    Currently, can be seen a new trend in engineering geological survey, where laboratory analysis are replaced by in situ testing methods, which are more efficient and cost effective, and time saving too. A regular engineering geological survey cannot be provided by simple core drillings, macroscopic description (sometimes very subjective), and then geotechnical parameters are established based on indicative standardized values or archive values from previous geotechnical standards. The engineering geological survey is trustworthy if is composed of laboratory and in-situ testing supplemented by indirect methods of testing, [1]. The prevalence of rotary core drilling for obtaining laboratory soil samples from various depths (every 1 to 3 m), cannot be a more enhanced as continues evaluation of strata and properties e.g. by CPT Piezocone (every 1 cm). Core drillings survey generally uses small amounts of soil samples, but this is resulting to a lower representation of the subsoil and underestimation of parameters. Higher amounts of soil samples make laboratory testing time-consuming and results from this testing can be influenced by the storage and processing of the soil samples. Preference for geotechnical surveys with in situ testing is therefore a more suitable option. In situ testing using static and dynamic penetration tests can be used as a supplement or as a replacement for the (traditional) methods of surveying.

  8. Parity-odd and CPT-even electrodynamics of the standard model extension at finite temperature

    Science.gov (United States)

    Casana, Rodolfo; Ferreira, Manoel M., Jr.; Silva, Madson R. O.

    2010-05-01

    This work examines the finite temperature properties of the CPT-even and parity-odd electrodynamics of the standard model extension. The starting point is the partition function computed for an arbitrary and sufficiently small tensor (kF)ανρφ [see R. Casana, M. M. Ferreira, Jr., J. S. Rodrigues, and M. R. O. Silva, Phys. Rev. DPRVDAQ1550-7998 80, 085026 (2009).10.1103/PhysRevD.80.085026]. After specializing the Lorentz-violating tensor (kF)ανρφ for the leading-order-nonbirefringent and parity-odd coefficients, the partition function is explicitly carried out, showing that it is a power of the Maxwell partition function. Also, it is observed that the Lorentz invariance violation coefficients induce an anisotropy in the black-body angular energy density distribution. Planck’s radiation law retains its usual frequency dependence and the Stefan-Boltzmann law keeps the same form, except for a global proportionality constant.

  9. Dimensional reduction of the CPT-even electromagnetic sector of the standard model extension

    Science.gov (United States)

    Casana, Rodolfo; Carvalho, Eduardo S.; Ferreira, Manoel M., Jr.

    2011-08-01

    The CPT-even Abelian gauge sector of the standard model extension is represented by the Maxwell term supplemented by (KF)μνρσFμνFρσ, where the Lorentz-violating background tensor, (KF)μνρσ, possesses the symmetries of the Riemann tensor. In the present work, we examine the planar version of this theory, obtained by means of a typical dimensional reduction procedure to (1+2) dimensions. The resulting planar electrodynamics is composed of a gauge sector containing six Lorentz-violating coefficients, a scalar field endowed with a noncanonical kinetic term, and a coupling term that links the scalar and gauge sectors. The dispersion relation is exactly determined, revealing that the six parameters related to the pure electromagnetic sector do not yield birefringence at any order. In this model, the birefringence may appear only as a second order effect associated with the coupling tensor linking the gauge and scalar sectors. The equations of motion are written and solved in the stationary regime. The Lorentz-violating parameters do not alter the asymptotic behavior of the fields but induce an angular dependence not observed in the Maxwell planar theory.

  10. Aspects of a planar nonbirefringent and CPT-even electrodynamics stemming from the standard model extension

    Science.gov (United States)

    Casana, Rodolfo; Ferreira, Manoel M., Jr.; Moreira, Roemir P. M.

    2011-12-01

    We have studied a (1+2)-dimensional Lorentz-violating model which is obtained from the dimensional reduction of the nonbirefringent sector of the CPT-even electrodynamics of the standard model extension. The planar theory contains a gauge sector and a scalar sector which are linearly coupled by means of a Lorentz-invariance violating (LIV) vector, Sμ, while the kinetic terms of both sectors are affected by the components of a Lorentz-violating symmetric tensor, κμν. The energy-momentum tensor reveals that both sectors present energy stability for sufficiently small values of the Lorentz-violating parameters. The full dispersion relation equations are exactly determined and analyzed for some special configurations of the LIV backgrounds, showing that the planar model is entirely nonbirefringent at any order in the LIV parameters. At first order, the gauge and scalar sectors are described by the same dispersion relations. Finally, the equations of motion have been solved in the stationary regime and at first order in the LIV parameters. It is observed that the Lorentz-violating parameters do not alter the asymptotical behavior of the electric and magnetic fields but induce an angular dependence which is not present in Maxwell’s planar theory.

  11. CPT Profiling and Laboratory Data Correlations for Deriving of Selected Geotechnical Parameter

    Directory of Open Access Journals (Sweden)

    Bulko Roman

    2015-12-01

    Full Text Available Currently, can be seen a new trend in engineering geological survey, where laboratory analysis are replaced by in situ testing methods, which are more efficient and cost effective, and time saving too. A regular engineering geological survey cannot be provided by simple core drillings, macroscopic description (sometimes very subjective, and then geotechnical parameters are established based on indicative standardized values or archive values from previous geotechnical standards. The engineering geological survey is trustworthy if is composed of laboratory and in-situ testing supplemented by indirect methods of testing, [1]. The prevalence of rotary core drilling for obtaining laboratory soil samples from various depths (every 1 to 3 m, cannot be a more enhanced as continues evaluation of strata and properties e.g. by CPT Piezocone (every 1 cm. Core drillings survey generally uses small amounts of soil samples, but this is resulting to a lower representation of the subsoil and underestimation of parameters. Higher amounts of soil samples make laboratory testing time-consuming and results from this testing can be influenced by the storage and processing of the soil samples. Preference for geotechnical surveys with in situ testing is therefore a more suitable option. In situ testing using static and dynamic penetration tests can be used as a supplement or as a replacement for the (traditional methods of surveying.

  12. Genuine T, CP, CPT asymmetry parameters for the entangled $\\boldsymbol{B_d}$ system

    CERN Document Server

    Bernabeu, Jose; Nebot, Miguel

    2016-01-01

    The precise connection between the theoretical T, CP, CPT asymmetries, in terms of transition probabilities between the filtered neutral meson $B_d$ states and the experimental asymmetries between the double decay rate Intensities for Flavour-CP eigenstate decay products in a B-Factory of entangled states, is established. This allows the identification of Genuine Asymmetry Parameters in the time distribution of the Asymmetries and their measurability by disentangling genuine and possible fake terms. We express the nine asymmetry parameters -- three different observables for each one of the three symmetries -- in terms of the ingredients of the Weisskopf-Wigner dynamical description of the entangled $B_d$-meson states and we obtain a global fit to their values from the BaBar Collaboration experimental results. The possible fake terms are all compatible with zero and the information content of the nine asymmetry parameters is indeed different. The non-vanishing $\\Delta\\mathscr S_c^{\\rm T} =-0.687\\pm 0.020 $ and...

  13. Simulating pile load-settlement behavior from CPT data using intelligent computing

    Science.gov (United States)

    Alkroosh, I.; Nikraz, H.

    2011-09-01

    Analysis of pile load-settlement behavior is a complex problem due to the participation of many factors involved. This paper presents a new procedure based on artificial neural networks (ANNs) for simulating the load-settlement behavior of pile foundations embedded in sand and mixed soils (subjected to axial loads). Three ANN models have been developed, a model for bored piles and two other models for driven piles (a model for each of concrete and steel piles). The data used for development of the ANN models is collected from the literature and comprise a series of in-situ piles load tests as well as cone penetration test (CPT) results. The data of each model is divided into two subsets: Training set for model calibration and independent validation set for model verification. Predictions from the ANN models are compared with the results of experimental data and with predictions of number of currently adopted load-transfer methods. Statistical analysis is used to verify the performance of the models. The results indicate that the ANN model performs very well and able to predict the pile load-settlement behaviour accurately.

  14. Task I: Dark Matter Search Experiments with Cryogenic Detectors: CDMS-I and CDMS-II Task II: Experimental Study of Neutrino Properties: EXO and KamLAND

    Energy Technology Data Exchange (ETDEWEB)

    Cabrera, Blas [Stanford Univ., CA (United States); Gratta, Giorgio [Stanford Univ., CA (United States)

    2013-08-30

    design and optimize the analysis. Neutrino Physics – In the period of performance the neutrino group successfully completed the construction of EXO-200 and commissioned the detector. Science data taking started on Jun 1, 2011. With the discovery of the 2-neutrino double-beta decay in 136-Xe and the first measurement of the 0-neutrino mode resulting in the most stringent limit of Majorana masses, our group continues to be a leading innovator in the field of neutrino physics which is central to DOE-HEP Intensity Frontier program. The phenomenon of neutrino oscillations, in part elucidated by our earlier efforts with the Palo Verde and KamLAND experiments, provides the crucial information that neutrino masses are non-zero and, yet, it contains no information on the value of the neutrino mass scale. In recent times our group has therefore shifted its focus to a high sensitivity 0-neutrino double beta decay program, EXO. The 0-neutrino double beta decay provides the best chance of extending the sensitivity to the neutrino mass scale below 10 meV but, maybe more importantly, it tests the nature of the neutrino wave function, providing the most sensitive probe for Majorana particles and lepton number violation. The EXO program, formulated by our group several years ago, plans to use up to tonnes of the isotope 136-Xe to study the 0-neutrino double beta decay mode. The EXO-200 detector is the first step in this program and it represents the only large US-led and based experiment taking data. The EXO-200 isotope enrichment program broke new grounds for the enterprise of double beta decay. The detector design and material selection program paid off, resulting in a background that is among the very best in the field. The “first light" of EXO-200 was very exciting with the discovery -in the first month of data- of the rarest 2-neutrino double beta decay mode ever observed. The lower limit on the 0-neutrino double beta decay half-life, published in Phys. Rev. Lett. and based on

  15. Search for T, CP, and CPT violation in B0-B0 mixing with inclusive dilepton events.

    Science.gov (United States)

    Aubert, B; Barate, R; Bona, M; Boutigny, D; Couderc, F; Karyotakis, Y; Lees, J P; Poireau, V; Tisserand, V; Zghiche, A; Grauges, E; Palano, A; Pappagallo, M; Chen, J C; Qi, N D; Rong, G; Wang, P; Zhu, Y S; Eigen, G; Ofte, I; Stugu, B; Abrams, G S; Battaglia, M; Brown, D N; Button-Shafer, J; Cahn, R N; Charles, E; Day, C T; Gill, M S; Groysman, Y; Jacobsen, R G; Kadyk, J A; Kerth, L T; Kolomensky, Yu G; Kukartsev, G; Lynch, G; Mir, L M; Oddone, P J; Orimoto, T J; Pripstein, M; Roe, N A; Ronan, M T; Wenzel, W A; Barrett, M; Ford, K E; Harrison, T J; Hart, A J; Hawkes, C M; Morgan, S E; Watson, A T; Goetzen, K; Held, T; Koch, H; Lewandowski, B; Pelizaeus, M; Peters, K; Schroeder, T; Steinke, M; Boyd, J T; Burke, J P; Cottingham, W N; Walker, D; Cuhadar-Donszelmann, T; Fulsom, B G; Hearty, C; Knecht, N S; Mattison, T S; McKenna, J A; Khan, A; Kyberd, P; Saleem, M; Teodorescu, L; Blinov, V E; Bukin, A D; Druzhinin, V P; Golubev, V B; Onuchin, A P; Serednyakov, S I; Skovpen, Yu I; Solodov, E P; Todyshev, K Yu; Best, D S; Bondioli, M; Bruinsma, M; Chao, M; Curry, S; Eschrich, I; Kirkby, D; Lankford, A J; Lund, P; Mandelkern, M; Mommsen, R K; Roethel, W; Stoker, D P; Abachi, S; Buchanan, C; Foulkes, S D; Gary, J W; Long, O; Shen, B C; Wang, K; Zhang, L; Hadavand, H K; Hill, E J; Paar, H P; Rahatlou, S; Sharma, V; Berryhill, J W; Campagnari, C; Cunha, A; Dahmes, B; Hong, T M; Kovalskyi, D; Richman, J D; Beck, T W; Eisner, A M; Flacco, C J; Heusch, C A; Kroseberg, J; Lockman, W S; Nesom, G; Schalk, T; Schumm, B A; Seiden, A; Spradlin, P; Williams, D C; Wilson, M G; Albert, J; Chen, E; Dvoretskii, A; Hitlin, D G; Narsky, I; Piatenko, T; Porter, F C; Ryd, A; Samuel, A; Andreassen, R; Mancinelli, G; Meadows, B T; Sokoloff, M D; Blanc, F; Bloom, P C; Chen, S; Ford, W T; Hirschauer, J F; Kreisel, A; Nauenberg, U; Olivas, A; Ruddick, W O; Smith, J G; Ulmer, K A; Wagner, S R; Zhang, J; Chen, A; Eckhart, E A; Soffer, A; Toki, W H; Wilson, R J; Winklmeier, F; Zeng, Q; Altenburg, D D; Feltresi, E; Hauke, A; Jasper, H; Spaan, B; Brandt, T; Klose, V; Lacker, H M; Mader, W F; Nogowski, R; Petzold, A; Schubert, J; Schubert, K R; Schwierz, R; Sundermann, J E; Volk, A; Bernard, D; Bonneaud, G R; Grenier, P; Latour, E; Thiebaux, Ch; Verderi, M; Bard, D J; Clark, P J; Gradl, W; Muheim, F; Playfer, S; Robertson, A I; Xie, Y; Andreotti, M; Bettoni, D; Bozzi, C; Calabrese, R; Cibinetto, G; Luppi, E; Negrini, M; Petrella, A; Piemontese, L; Prencipe, E; Anulli, F; Baldini-Ferroli, R; Calcaterra, A; de Sangro, R; Finocchiaro, G; Pacetti, S; Patteri, P; Peruzzi, I M; Piccolo, M; Rama, M; Zallo, A; Buzzo, A; Capra, R; Contri, R; Lo Vetere, M; Macri, M M; Monge, M R; Passaggio, S; Patrignani, C; Robutti, E; Santroni, A; Tosi, S; Brandenburg, G; Chaisanguanthum, K S; Morii, M; Wu, J; Dubitzky, R S; Marks, J; Schenk, S; Uwer, U; Bhimji, W; Bowerman, D A; Dauncey, P D; Egede, U; Flack, R L; Gaillard, J R; Nash, J A; Nikolich, M B; Panduro Vazquez, W; Chai, X; Charles, M J; Mallik, U; Meyer, N T; Ziegler, V; Cochran, J; Crawley, H B; Dong, L; Eyges, V; Meyer, W T; Prell, S; Rosenberg, E I; Rubin, A E; Gritsan, A V; Fritsch, M; Schott, G; Arnaud, N; Davier, M; Grosdidier, G; Höcker, A; Le Diberder, F; Lepeltier, V; Lutz, A M; Oyanguren, A; Pruvot, S; Rodier, S; Roudeau, P; Schune, M H; Stocchi, A; Wang, W F; Wormser, G; Cheng, C H; Lange, D J; Wright, D M; Chavez, C A; Forster, I J; Fry, J R; Gabathuler, E; Gamet, R; George, K A; Hutchcroft, D E; Payne, D J; Schofield, K C; Touramanis, C; Bevan, A J; Di Lodovico, F; Menges, W; Sacco, R; Brown, C L; Cowan, G; Flaecher, H U; Hopkins, D A; Jackson, P S; McMahon, T R; Ricciardi, S; Salvatore, F; Brown, D N; Davis, C L; Allison, J; Barlow, N R; Barlow, R J; Chia, Y M; Edgar, C L; Kelly, M P; Lafferty, G D; Naisbit, M T; Williams, J C; Yi, J I; Chen, C; Hulsbergen, W D; Jawahery, A; Lae, C K; Roberts, D A; Simi, G; Blaylock, G; Dallapiccola, C; Hertzbach, S S; Li, X; Moore, T B; Saremi, S; Staengle, H; Willocq, S Y; Cowan, R; Koeneke, K; Sciolla, G; Sekula, S J; Spitznagel, M; Taylor, F; Yamamoto, R K; Kim, H; Patel, P M; Potter, C T; Robertson, S H; Lazzaro, A; Lombardo, V; Palombo, F; Bauer, J M; Cremaldi, L; Eschenburg, V; Godang, R; Kroeger, R; Reidy, J; Sanders, D A; Summers, D J; Zhao, H W; Brunet, S; Côté, D; Simard, M; Taras, P; Viaud, F B; Nicholson, H; Cavallo, N; De Nardo, G; del Re, D; Fabozzi, F; Gatto, C; Lista, L; Monorchio, D; Piccolo, D; Sciacca, C; Baak, M; Bulten, H; Raven, G; Snoek, H L; Jessop, C P; LoSecco, J M; Allmendinger, T; Benelli, G; Gan, K K; Honscheid, K; Hufnagel, D; Jackson, P D; Kagan, H; Kass, R; Pulliam, T; Rahimi, A M; Ter-Antonyan, R; Wong, Q K; Blount, N L; Brau, J; Frey, R; Igonkina, O; Lu, M; Rahmat, R; Sinev, N B; Strom, D; Strube, J; Torrence, E; Galeazzi, F; Gaz, A; Margoni, M; Morandin, M; Pompili, A; Posocco, M; Rotondo, M; Simonetto, F; Stroili, R; Voci, C; Benayoun, M; Chauveau, J; David, P; Del Buono, L; de la Vaissière, Ch; Hamon, O; Hartfiel, B L; John, M J J; Leruste, Ph; Malclès, J; Ocariz, J; Roos, L; Therin, G; Behera, P K; Gladney, L; Panetta, J; Biasini, M; Covarelli, R; Pioppi, M; Angelini, C; Batignani, G; Bettarini, S; Bucci, F; Calderini, G; Carpinelli, M; Cenci, R; Forti, F; Giorgi, M A; Lusiani, A; Marchiori, G; Mazur, M A; Morganti, M; Neri, N; Paoloni, E; Rizzo, G; Walsh, J; Haire, M; Judd, D; Wagoner, D E; Biesiada, J; Danielson, N; Elmer, P; Lau, Y P; Lu, C; Olsen, J; Smith, A J S; Telnov, A V; Bellini, F; Cavoto, G; D'Orazio, A; Di Marco, E; Faccini, R; Ferrarotto, F; Ferroni, F; Gaspero, M; Li Gioi, L; Mazzoni, M A; Morganti, S; Piredda, G; Polci, F; Safai Tehrani, F; Voena, C; Ebert, M; Schröder, H; Waldi, R; Adye, T; De Groot, N; Franek, B; Olaiya, E O; Wilson, F F; Emery, S; Gaidot, A; Ganzhur, S F; Hamel de Monchenault, G; Kozanecki, W; Legendre, M; Mayer, B; Vasseur, G; Yèche, Ch; Zito, M; Park, W; Purohit, M V; Weidemann, A W; Wilson, J R; Allen, M T; Aston, D; Bartoldus, R; Bechtle, P; Berger, N; Boyarski, A M; Claus, R; Coleman, J P; Convery, M R; Cristinziani, M; Dingfelder, J C; Dong, D; Dorfan, J; Dubois-Felsmann, G P; Dujmic, D; Dunwoodie, W; Field, R C; Glanzman, T; Gowdy, S J; Graham, M T; Halyo, V; Hast, C; Hryn'ova, T; Innes, W R; Kelsey, M H; Kim, P; Kocian, M L; Leith, D W G S; Li, S; Libby, J; Luitz, S; Luth, V; Lynch, H L; MacFarlane, D B; Marsiske, H; Messner, R; Muller, D R; O'grady, C P; Ozcan, V E; Perazzo, A; Perl, M; Ratcliff, B N; Roodman, A; Salnikov, A A; Schindler, R H; Schwiening, J; Snyder, A; Stelzer, J; Su, D; Sullivan, M K; Suzuki, K; Swain, S K; Thompson, J M; Va'vra, J; van Bakel, N; Weaver, M; Weinstein, A J R; Wisniewski, W J; Wittgen, M; Wright, D H; Yarritu, A K; Yi, K; Young, C C; Burchat, P R; Edwards, A J; Majewski, S A; Petersen, B A; Roat, C; Wilden, L; Ahmed, S; Alam, M S; Bula, R; Ernst, J A; Jain, V; Pan, B; Saeed, M A; Wappler, F R; Zain, S B; Bugg, W; Krishnamurthy, M; Spanier, S M; Eckmann, R; Ritchie, J L; Satpathy, A; Schilling, C J; Schwitters, R F; Izen, J M; Kitayama, I; Lou, X C; Ye, S; Bianchi, F; Gallo, F; Gamba, D; Bomben, M; Bosisio, L; Cartaro, C; Cossutti, F; Della Ricca, G; Dittongo, S; Grancagnolo, S; Lanceri, L; Vitale, L; Azzolini, V; Martinez-Vidal, F; Banerjee, Sw; Bhuyan, B; Brown, C M; Fortin, D; Hamano, K; Kowalewski, R; Nugent, I M; Roney, J M; Sobie, R J; Back, J J; Harrison, P F; Latham, T E; Mohanty, G B; Band, H R; Chen, X; Cheng, B; Dasu, S; Datta, M; Eichenbaum, A M; Flood, K T; Hollar, J J; Johnson, J R; Kutter, P E; Li, H; Liu, R; Mellado, B; Mihalyi, A; Mohapatra, A K; Pan, Y; Pierini, M; Prepost, R; Tan, P; Wu, S L; Yu, Z; Neal, H

    2006-06-30

    We report the results of a search for T, CP, CPT, and violation in B0-B0 mixing using an inclusive dilepton sample collected by the BABAR experiment at the PEP-II factory. Using a sample of 232 x 10(6) BB pairs, we measure the T and CP violation parameter |q/p| - 1 = (-0.8 +/- 2.7(stat) +/- 1.9(syst) x 10(-3), and the CPT and CP parameters Imz = (13.9 +/- 7.3(stat) +/- 3.2(syst)) x 10(-3) and Delta Gamma x Rez = (7.1 +/- 3.9(stat) +/- 2.0(stat)) x 10(-3) ps(-1). The statistical correlation between the measurements of Imz and Delta Gamma x Rez is 76%.

  16. Search for CPT and lorentz violation in B0-B[over ]0 oscillations with dilepton events.

    Science.gov (United States)

    Aubert, B; Bona, M; Boutigny, D; Karyotakis, Y; Lees, J P; Poireau, V; Prudent, X; Tisserand, V; Zghiche, A; Garra Tico, J; Grauges, E; Lopez, L; Palano, A; Pappagallo, M; Eigen, G; Stugu, B; Sun, L; Abrams, G S; Battaglia, M; Brown, D N; Button-Shafer, J; Cahn, R N; Groysman, Y; Jacobsen, R G; Kadyk, J A; Kerth, L T; Kolomensky, Yu G; Kukartsev, G; Lopes Pegna, D; Lynch, G; Mir, L M; Orimoto, T J; Osipenkov, I L; Ronan, M T; Tackmann, K; Tanabe, T; Wenzel, W A; Del Amo Sanchez, P; Hawkes, C M; Watson, A T; Koch, H; Schroeder, T; Walker, D; Asgeirsson, D J; Cuhadar-Donszelmann, T; Fulsom, B G; Hearty, C; Mattison, T S; McKenna, J A; Barrett, M; Khan, A; Saleem, M; Teodorescu, L; Blinov, V E; Bukin, A D; Druzhinin, V P; Golubev, V B; Onuchin, A P; Serednyakov, S I; Skovpen, Yu I; Solodov, E P; Todyshev, K Yu; Bondioli, M; Curry, S; Eschrich, I; Kirkby, D; Lankford, A J; Lund, P; Mandelkern, M; Martin, E C; Stoker, D P; Abachi, S; Buchanan, C; Gary, J W; Liu, F; Long, O; Shen, B C; Vitug, G M; Zhang, L; Paar, H P; Rahatlou, S; Sharma, V; Berryhill, J W; Campagnari, C; Cunha, A; Dahmes, B; Hong, T M; Kovalskyi, D; Richman, J D; Beck, T W; Eisner, A M; Flacco, C J; Heusch, C A; Kroseberg, J; Lockman, W S; Schalk, T; Schumm, B A; Seiden, A; Wilson, M G; Winstrom, L O; Chen, E; Cheng, C H; Fang, F; Hitlin, D G; Narsky, I; Piatenko, T; Porter, F C; Andreassen, R; Mancinelli, G; Meadows, B T; Mishra, K; Sokoloff, M D; Blanc, F; Bloom, P C; Chen, S; Ford, W T; Hirschauer, J F; Kreisel, A; Nagel, M; Nauenberg, U; Olivas, A; Smith, J G; Ulmer, K A; Wagner, S R; Zhang, J; Gabareen, A M; Soffer, A; Toki, W H; Wilson, R J; Winklmeier, F; Altenburg, D D; Feltresi, E; Hauke, A; Jasper, H; Merkel, J; Petzold, A; Spaan, B; Wacker, K; Klose, V; Kobel, M J; Lacker, H M; Mader, W F; Nogowski, R; Schubert, J; Schubert, K R; Schwierz, R; Sundermann, J E; Volk, A; Bernard, D; Bonneaud, G R; Latour, E; Lombardo, V; Thiebaux, Ch; Verderi, M; Clark, P J; Gradl, W; Muheim, F; Playfer, S; Robertson, A I; Watson, J E; Xie, Y; Andreotti, M; Bettoni, D; Bozzi, C; Calabrese, R; Cecchi, A; Cibinetto, G; Franchini, P; Luppi, E; Negrini, M; Petrella, A; Piemontese, L; Prencipe, E; Santoro, V; Anulli, F; Baldini-Ferroli, R; Calcaterra, A; de Sangro, R; Finocchiaro, G; Pacetti, S; Patteri, P; Peruzzi, I M; Piccolo, M; Rama, M; Zallo, A; Buzzo, A; Contri, R; Lo Vetere, M; Macri, M M; Monge, M R; Passaggio, S; Patrignani, C; Robutti, E; Santroni, A; Tosi, S; Chaisanguanthum, K S; Morii, M; Wu, J; Dubitzky, R S; Marks, J; Schenk, S; Uwer, U; Bard, D J; Dauncey, P D; Flack, R L; Nash, J A; Panduro Vazquez, W; Tibbetts, M; Behera, P K; Chai, X; Charles, M J; Mallik, U; Cochran, J; Crawley, H B; Dong, L; Eyges, V; Meyer, W T; Prell, S; Rosenberg, E I; Rubin, A E; Gao, Y Y; Gritsan, A V; Guo, Z J; Lae, C K; Denig, A G; Fritsch, M; Schott, G; Arnaud, N; Béquilleux, J; D'Orazio, A; Davier, M; Grosdidier, G; Höcker, A; Lepeltier, V; Le Diberder, F; Lutz, A M; Pruvot, S; Rodier, S; Roudeau, P; Schune, M H; Serrano, J; Sordini, V; Stocchi, A; Wang, L; Wang, W F; Wormser, G; Lange, D J; Wright, D M; Bingham, I; Burke, J P; Chavez, C A; Fry, J R; Gabathuler, E; Gamet, R; Hutchcroft, D E; Payne, D J; Schofield, K C; Touramanis, C; Bevan, A J; George, K A; Di Lodovico, F; Sacco, R; Cowan, G; Flaecher, H U; Hopkins, D A; Paramesvaran, S; Salvatore, F; Wren, A C; Brown, D N; Davis, C L; Allison, J; Barlow, N R; Barlow, R J; Chia, Y M; Edgar, C L; Lafferty, G D; West, T J; Yi, J I; Anderson, J; Chen, C; Jawahery, A; Roberts, D A; Simi, G; Tuggle, J M; Dallapiccola, C; Hertzbach, S S; Li, X; Moore, T B; Salvati, E; Saremi, S; Cowan, R; Dujmic, D; Fisher, P H; Koeneke, K; Sciolla, G; Spitznagel, M; Taylor, F; Yamamoto, R K; Zhao, M; Zheng, Y; McLachlin, S E; Patel, P M; Robertson, S H; Lazzaro, A; Palombo, F; Bauer, J M; Cremaldi, L; Eschenburg, V; Godang, R; Kroeger, R; Sanders, D A; Summers, D J; Zhao, H W; Brunet, S; Côté, D; Simard, M; Taras, P; Viaud, F B; Nicholson, H; De Nardo, G; Fabozzi, F; Lista, L; Monorchio, D; Sciacca, C; Baak, M A; Raven, G; Snoek, H L; Jessop, C P; Knoepfel, K J; Losecco, J M; Benelli, G; Corwin, L A; Honscheid, K; Kagan, H; Kass, R; Morris, J P; Rahimi, A M; Regensburger, J J; Sekula, S J; Wong, Q K; Blount, N L; Brau, J; Frey, R; Igonkina, O; Kolb, J A; Lu, M; Rahmat, R; Sinev, N B; Strom, D; Strube, J; Torrence, E; Gagliardi, N; Gaz, A; Margoni, M; Morandin, M; Pompili, A; Posocco, M; Rotondo, M; Simonetto, F; Stroili, R; Voci, C; Ben-Haim, E; Briand, H; Calderini, G; Chauveau, J; David, P; Del Buono, L; de la Vaissière, Ch; Hamon, O; Leruste, Ph; Malclès, J; Ocariz, J; Perez, A; Prendki, J; Gladney, L; Biasini, M; Covarelli, R; Manoni, E; Angelini, C; Batignani, G; Bettarini, S; Carpinelli, M; Cenci, R; Cervelli, A; Forti, F; Giorgi, M A; Lusiani, A; Marchiori, G; Mazur, M A; Morganti, M; Neri, N; Paoloni, E; Rizzo, G; Walsh, J J; Biesiada, J; Elmer, P; Lau, Y P; Lu, C; Olsen, J; Smith, A J S; Telnov, A V; Baracchini, E; Bellini, F; Cavoto, G; Del Re, D; Di Marco, E; Faccini, R; Ferrarotto, F; Ferroni, F; Gaspero, M; Jackson, P D; Mazzoni, M A; Morganti, S; Piredda, G; Polci, F; Renga, F; Voena, C; Ebert, M; Hartmann, T; Schröder, H; Waldi, R; Adye, T; Castelli, G; Franek, B; Olaiya, E O; Roethel, W; Wilson, F F; Emery, S; Escalier, M; Gaidot, A; Ganzhur, S F; Hamel de Monchenault, G; Kozanecki, W; Vasseur, G; Yèche, Ch; Zito, M; Chen, X R; Liu, H; Park, W; Purohit, M V; White, R M; Wilson, J R; Allen, M T; Aston, D; Bartoldus, R; Bechtle, P; Claus, R; Coleman, J P; Convery, M R; Dingfelder, J C; Dorfan, J; Dubois-Felsmann, G P; Dunwoodie, W; Field, R C; Glanzman, T; Gowdy, S J; Graham, M T; Grenier, P; Hast, C; Innes, W R; Kaminski, J; Kelsey, M H; Kim, H; Kim, P; Kocian, M L; Leith, D W G S; Li, S; Luitz, S; Luth, V; Lynch, H L; Macfarlane, D B; Marsiske, H; Messner, R; Muller, D R; Nelson, S; O'Grady, C P; Ofte, I; Perazzo, A; Perl, M; Pulliam, T; Ratcliff, B N; Roodman, A; Salnikov, A A; Schindler, R H; Schwiening, J; Snyder, A; Su, D; Sullivan, M K; Suzuki, K; Swain, S K; Thompson, J M; Va'vra, J; Wagner, A P; Weaver, M; Wisniewski, W J; Wittgen, M; Wright, D H; Yarritu, A K; Yi, K; Young, C C; Ziegler, V; Burchat, P R; Edwards, A J; Majewski, S A; Miyashita, T S; Petersen, B A; Wilden, L; Ahmed, S; Alam, M S; Bula, R; Ernst, J A; Pan, B; Saeed, M A; Wappler, F R; Zain, S B; Spanier, S M; Wogsland, B J; Eckmann, R; Ritchie, J L; Ruland, A M; Schilling, C J; Schwitters, R F; Izen, J M; Lou, X C; Ye, S; Bianchi, F; Gallo, F; Gamba, D; Pelliccioni, M; Bomben, M; Bosisio, L; Cartaro, C; Cossutti, F; Della Ricca, G; Lanceri, L; Vitale, L; Azzolini, V; Lopez-March, N; Martinez-Vidal, F; Milanes, D A; Oyanguren, A; Albert, J; Banerjee, Sw; Bhuyan, B; Hamano, K; Kowalewski, R; Nugent, I M; Roney, J M; Sobie, R J; Harrison, P F; Ilic, J; Latham, T E; Mohanty, G B; Band, H R; Chen, X; Dasu, S; Flood, K T; Hollar, J J; Kutter, P E; Pan, Y; Pierini, M; Prepost, R; Wu, S L; Neal, H

    2008-04-04

    We report results of a search for CPT and Lorentz violation in B(0)-B[over ](0) oscillations using inclusive dilepton events from 232 x 10(6) Upsilon(4S)-->BB[over ] decays recorded by the BABAR detector at the PEP-II B Factory at SLAC. We find 2.8sigma significance, compatible with no signal, for variations in the complex CPT violation parameter z at the Earth's sidereal frequency and extract values for the quantities Deltaa(micro) in the general Lorentz-violating standard-model extension. The spectral powers for variations in z over the frequency range 0.26 yr(-1) to 2.1 solar day(-1) are also compatible with no signal.

  17. Search for T, CP and CPT Violation in B0-B0bar Mixing with Inclusive Dilepton Events

    CERN Document Server

    Aubert, B; Barate, R; Bóna, M; Boutigny, D; Couderc, F; Karyotakis, Yu; Lees, J P; Poireau, V; Tisserand, V; Zghiche, A; Graugès-Pous, E; Palano, A; Pappagallo, M; Chen, J C; Qi, N D; Rong, G; Wang, P; Zhu, Y S; Eigen, G; Ofte, I; Stugu, B; Abrams, G S; Battaglia, M; Brown, D N; Button-Shafer, J; Cahn, R N; Charles, E; Day, C T; Gill, M S; Groysman, Y; Jacobsen, R G; Kadyk, J A; Kerth, L T; Kolomensky, Yu G; Kukartsev, G; Lynch, G; Mir, L M; Oddone, P J; Orimoto, T J; Pripstein, M; Roe, N A; Ronan, M T; Wenzel, W A; Barrett, M; Ford, K E; Harrison, T J; Hart, A J; Hawkes, C M; Morgan, S E; Watson, A T; Goetzen, K; Held, T; Koch, H; Lewandowski, B; Pelizaeus, M; Peters, K; Schröder, T; Steinke, M; Boyd, J T; Burke, J P; Cottingham, W N; Walker, D; Çuhadar-Dönszelmann, T; Fulsom, B G; Hearty, C; Knecht, N S; Mattison, T S; McKenna, J A; Khan, A; Kyberd, P; Saleem, M; Teodorescu, L; Blinov, V E; Bukin, A D; Druzhinin, V P; Golubev, V B; Onuchin, A P; Serednyakov, S I; Skovpen, Yu I; Solodov, E P; Todyshev, Yu K; Best, D S; Bondioli, M; Bruinsma, M; Chao, M; Curry, S; Eschrich, I; Kirkby, D; Lankford, A J; Lund, P; Mandelkern, M A; Mommsen, R K; Röthel, W; Stoker, D P; Abachi, S; Buchanan, C; Foulkes, S D; Gary, J W; Long, O; Shen, B C; Wang, K; Zhang, L; Hadavand, H K; Hill, E J; Paar, H P; Rahatlou, S; Sharma, V; Berryhill, J W; Campagnari, C; Cunha, A; Dahmes, B; Hong, T M; Kovalskyi, D; Richman, J D; Beck, T W; Eisner, A M; Flacco, C J; Heusch, C A; Kroseberg, J; Lockman, W S; Nesom, G; Schalk, T; Schumm, B A; Seiden, A; Spradlin, P; Williams, D C; Wilson, M G; Albert, J; Chen, E; Dvoretskii, A; Hitlin, D G; Narsky, I; Piatenko, T; Porter, F C; Ryd, A; Samuel, A; Andreassen, R; Mancinelli, G; Meadows, B T; Sokoloff, M D; Blanc, F; Bloom, P C; Chen, S; Ford, W T; Hirschauer, J F; Kreisel, A; Nauenberg, U; Olivas, A; Ruddick, W O; Smith, J G; Ulmer, K A; Wagner, S R; Zhang, J; Chen, A; Eckhart, E A; Soffer, A; Toki, W H; Wilson, R J; Winklmeier, F; Zeng, Q; Altenburg, D D; Feltresi, E; Hauke, A; Jasper, H; Spaan, B; Brandt, T; Klose, V; Lacker, H M; Mader, W F; Nogowski, R; Petzold, A; Schubert, J; Schubert, K R; Schwierz, R; Sundermann, J E; Volk, A; Bernard, D; Bonneaud, G R; Grenier, P; Latour, E; Thiebaux, C; Verderi, M; Bard, D J; Clark, P J; Gradl, W; Muheim, F; Playfer, S; Robertson, A I; Xie, Y; Andreotti, M; Bettoni, D; Bozzi, C; Calabrese, R; Cibinetto, G; Luppi, E; Negrini, M; Petrella, A; Piemontese, L; Prencipe, E; Anulli, F; Baldini-Ferroli, R; Calcaterra, A; De Sangro, R; Finocchiaro, G; Pacetti, S; Patteri, P; Peruzzi, I M; Piccolo, M; Rama, M; Zallo, A; Buzzo, A; Capra, R; Contri, R; Lo Vetere, M; Macri, M M; Monge, M R; Passaggio, S; Patrignani, C; Robutti, E; Santroni, A; Tosi, S; Brandenburg, G; Chaisanguanthum, K S; Morii, M; Wu, J; Dubitzky, R S; Marks, J; Schenk, S; Uwer, U; Bhimji, W; Bowerman, D A; Dauncey, P D; Egede, U; Flack, R L; Gaillard, J R; Nash, J A; Nikolich, M B; Panduro-Vazquez, W; Chai, X; Charles, M J; Mallik, U; Meyer, N T; Ziegler, V; Cochran, J; Crawley, H B; Dong, L; Eyges, V; Meyer, W T; Prell, S; Rosenberg, E I; Rubin, A E; Gritsan, A V; Fritsch, M; Schott, G; Arnaud, N; Davier, M; Grosdidier, G; Höcker, A; Le Diberder, F R; Lepeltier, V; Lutz, A M; Oyanguren, A; Pruvot, S; Rodier, S; Roudeau, P; Schune, M H; Stocchi, A; Wang, W F; Wormser, G; Cheng, C H; Lange, D J; Wright, D M; Chavez, C A; Forster, I J; Fry, J R; Gabathuler, E; Gamet, R; George, K A; Hutchcroft, D E; Payne, D J; Schofield, K C; Touramanis, C; Bevan, A J; Di Lodovico, F; Menges, W; Sacco, R; Brown, C L; Cowan, G; Flächer, H U; Hopkins, D A; Jackson, P S; McMahon, T R; Ricciardi, S; Salvatore, F; Davis, C L; Allison, J; Barlow, N R; Barlow, R J; Chia, Y M; Edgar, C L; Kelly, M P; Lafferty, G D; Naisbit, M T; Williams, J C; Yi, J I; Chen, C; Hulsbergen, W D; Jawahery, A; Lae, C K; Roberts, D A; Simi, G; Blaylock, G; Dallapiccola, C; Hertzbach, S S; Li, X; Moore, T B; Saremi, S; Stängle, H; Willocq, S Y; Cowan, R; Koeneke, K; Sciolla, G; Sekula, S J; Spitznagel, M; Taylor, F; Yamamoto, R K; Kim, H; Patel, P M; Potter, C T; Robertson, S H; Lazzaro, A; Lombardo, V; Palombo, F; Bauer, J M; Cremaldi, L; Eschenburg, V; Godang, R; Kroeger, R; Reidy, J; Sanders, D A; Summers, D J; Zhao, H W; Brunet, S; Côté, D; Simard, M; Taras, P; Viaud, F B; Nicholson, H; Cavallo, N; De Nardo, Gallieno; Del Re, D; Fabozzi, F; Gatto, C; Lista, L; Monorchio, D; Piccolo, D; Sciacca, C; Baak, M; Bulten, H; Raven, G; Snoek, H L; Jessop, C P; LoSecco, J M; Allmendinger, T; Benelli, G; Gan, K K; Honscheid, K; Hufnagel, D; Jackson, P D; Kagan, H; Kass, R; Pulliam, T; Rahimi, A M; Ter-Antonian, R; Wong, Q K; Blount, N L; Brau, J E; Frey, R; Igonkina, O; Lu, M; Rahmat, R; Sinev, N B; Strom, D; Strube, J; Torrence, E; Galeazzi, F; Gaz, A; Margoni, M; Morandin, M; Pompili, A; Posocco, M; Rotondo, M; Simonetto, F; Stroili, R; Voci, C; Benayoun, M; Chauveau, J; David, P; Del Buono, L; La Vaissière, C de; Hamon, O; Hartfiel, B L; John, M J J; Leruste, P; Malcles, J; Ocariz, J; Roos, L; Therin, G; Behera, P K; Gladney, L; Panetta, J; Biasini, M; Covarelli, R; Pioppi, M; Angelini, C; Batignani, G; Bettarini, S; Bucci, F; Calderini, G; Carpinelli, M; Cenci, R; Forti, F; Giorgi, M A; Lusiani, A; Marchiori, G; Mazur, M A; Morganti, M; Neri, N; Paoloni, E; Rizzo, G; Walsh, J; Haire, M; Judd, D; Wagoner, D E; Biesiada, J; Danielson, N; Elmer, P; Lau, Y P; Lü, C; Olsen, J; Smith, A J S; Telnov, A V; Bellini, F; Cavoto, G; D'Orazio, A; Di Marco, E; Faccini, R; Ferrarotto, F; Ferroni, F; Gaspero, M; Li Gioi, L; Mazzoni, M A; Morganti, S; Piredda, G; Polci, F; Safai-Tehrani, F; Voena, C; Ebert, M; Schröder, H; Waldi, R; Adye, T; De Groot, N; Franek, B; Olaiya, E O; Wilson, F F; Emery, S; Gaidot, A; Ganzhur, S F; Hamel de Monchenault, G; Kozanecki, Witold; Legendre, M; Mayer, B; Vasseur, G; Yéche, C; Zito, M; Park, W; Purohit, M V; Weidemann, A W; Wilson, J R; Allen, M T; Aston, D; Bartoldus, R; Bechtle, P; Berger, N; Boyarski, A M; Claus, R; Coleman, J P; Convery, M R; Cristinziani, M; Dingfelder, J C; Dong, D; Dorfan, J; Dubois-Felsmann, G P; Dujmic, D; Dunwoodie, W M; Field, R C; Glanzman, T; Gowdy, S J; Graham, M T; Halyo, V; Hast, C; Hrynóva, T; Innes, W R; Kelsey, M H; Kim, P; Kocian, M L; Leith, D W G S; Li, S; Libby, J; Luitz, S; Lüth, V; Lynch, H L; MacFarlane, D B; Marsiske, H; Messner, R; Müller, D R; O'Grady, C P; Ozcan, V E; Perazzo, A; Perl, M; Ratcliff, B N; Roodman, A; Salnikov, A A; Schindler, R H; Schwiening, J; Snyder, A; Stelzer, J; Su, D; Sullivan, M K; Suzuki, K; Swain, S K; Thompson, J M; Vavra, J; Van Bakel, N; Weaver, M; Weinstein, A J R; Wisniewski, W J; Wittgen, M; Wright, D H; Yarritu, A K; Yi, K; Young, C C; Burchat, P R; Edwards, A J; Majewski, S A; Petersen, B A; Roat, C; Wilden, L; Ahmed, S; Alam, M S; Bula, R; Ernst, J A; Jain, V; Pan, B; Saeed, M A; Wappler, F R; Zain, S B; Bugg, W; Krishnamurthy, M; Spanier, S M; Eckmann, R; Ritchie, J L; Satpathy, A; Schilling, C J; Schwitters, R F; Izen, J M; Kitayama, I; Lou, X C; Ye, S; Bianchi, F; Gallo, F; Gamba, D; Bomben, M; Bosisio, L; Cartaro, C; Cossutti, F; Della Ricca, G; Dittongo, S; Grancagnolo, S; Lanceri, L; Vitale, L; Azzolini, V; Martínez-Vidal, F; Banerjee, Sw; Bhuyan, B; Brown, C M; Fortin, D; Hamano, K; Kowalewski, R V; Nugent, I M; Roney, J M; Sobie, R J; Back, J J; Harrison, P F; Latham, T E; Mohanty, G B; Band, H R; Chen, X; Cheng, B; Dasu, S; Datta, M; Eichenbaum, A M; Flood, K T; Hollar, J J; Johnson, J R; Kutter, P E; Li, H; Liu, R; Mellado, B; Mihályi, A; Mohapatra, A K; Pan, Y; Pierini, M; Prepost, R; Tan, P; Wu, S L; Yu, Z; Neal, H

    2006-01-01

    We report the results of a search for T, CP and CPT violation in B0-B0bar mixing using an inclusive dilepton sample collected by the BaBar experiment at the PEP-II B Factory. Using a sample of 232 million BBbar pairs, with a simultaneous likelihood fit of the same-sign and opposite-sign dileptons, we measure the T and CP violation parameter |q/p|-1 = (-0.8 +/- 2.7(stat.) +/- 1.9(syst.))e-03, and the CPT and CP parameters Im(z) = (-13.9 +/- 7.3 (stat.) +/- 3.2(syst.))e-03 and DeltaGamma x Re(z) = (-7.1 +/- 3.9(stat.) +/- 2.0(syst.))e-03 ps^{-1}. The statistical correlation between the measurements of Im(z) and DeltaGamma x Re(z) is 76%.

  18. General CPT-even dimension-five nonminimal couplings between fermions and photons yielding EDM and MDM

    Directory of Open Access Journals (Sweden)

    Jonas B. Araujo

    2016-09-01

    Full Text Available In this letter, we examine a new class of CPT-even nonminimal interactions, between fermions and photons, deprived of higher order derivatives, that yields electric dipole moment (EDM and magnetic dipole moment (MDM in the context of the Dirac equation. The couplings are dimension-five CPT-even and Lorentz-violating nonminimal structures, composed of a rank-2 tensor, Tμν, the electromagnetic tensor, and gamma matrices, being addressed in its axial and non-axial Hermitian versions, and also comprising general possibilities. We then use the electron's anomalous magnetic dipole moment and electron electric dipole moment measurements to reach upper bounds of 1 part in 1020 and 1025 (eV−1.

  19. General CPT-even dimension-five nonminimal couplings between fermions and photons yielding EDM and MDM

    Science.gov (United States)

    Araujo, Jonas B.; Casana, Rodolfo; Ferreira, Manoel M.

    2016-09-01

    In this letter, we examine a new class of CPT-even nonminimal interactions, between fermions and photons, deprived of higher order derivatives, that yields electric dipole moment (EDM) and magnetic dipole moment (MDM) in the context of the Dirac equation. The couplings are dimension-five CPT-even and Lorentz-violating nonminimal structures, composed of a rank-2 tensor, Tμν, the electromagnetic tensor, and gamma matrices, being addressed in its axial and non-axial Hermitian versions, and also comprising general possibilities. We then use the electron's anomalous magnetic dipole moment and electron electric dipole moment measurements to reach upper bounds of 1 part in 1020 and 1025 (eV) - 1.

  20. Search for T, CP and CPT Violation in B0-B0bar Mixingwith Inclusive Dilepton Events

    Energy Technology Data Exchange (ETDEWEB)

    Aubert, B.

    2006-03-31

    The authors report the results of a search for T, CP and CPT violation in B{sup 0}-{bar B}{sup 0} mixing using an inclusive dilepton sample collected by the BABAR experiment at the PEP-II B Factory. Using a sample of 232 million B{bar B} pairs, with a simultaneous likelihood fit of the same-sign and opposite-sign dileptons, they measure the T and Cp violation parameter |q/p|-1 = (-0.8 {+-} 2.7(stat.) {+-} 1.9(syst.)) x 10{sup -3}, and the CPT and CP parameters Im z = (-13.9 {+-} 7.3(stat.) {+-} 3.2(syst.)) x 10{sup -3} and {Delta}{Lambda} x Re z = (-7.1 {+-} 3.9(stat.) {+-} 2.0(syst.)) x 10{sup -3} ps{sup -1}. The statistical correlation between the measurements of Im z and {Delta}{Lambda} x Re z is 76%.

  1. Topological BPS vortices in a Maxwell-Higgs model with a CPT-odd and Lorentz-violating nonminimal coupling

    CERN Document Server

    Casana, Rodolfo; Mota, Alexsandro Lucena

    2015-01-01

    We have studied the existence of topological self-dual vortices in a nonminimal CPT-odd and Lorentz-violating Maxwell-Higgs model. The Lorentz-violating nonminimal interaction is introduced via a modification of the usual covariant derivative coupling the Higgs and the gauge sectors. The self-dual solutions behave similarly to the Abrikosov-Nielsen-Olesen vortices, are electrically neutral and their total energy is proportional to the quantized magnetic flux.

  2. Exploration of CPT violation via time-dependent geometric quantities embedded in neutrino oscillation through fluctuating matter

    CERN Document Server

    Wang, Zisheng

    2015-01-01

    We propose a new approach to explore CPT violation of neutrino oscillation through a fluctuating matter based on time-dependent geometric quantities. By mapping the neutrino oscillation onto a Poincare sphere structure, we obtain an analytic solution of master equation and further define the geometric quantities, i.e., radius of Poincare sphere and geometric phase. We find that the mixing process between electron and muon neutrinos can be described by the radius of Poincare sphere that depends on the intrinsic CP-violating angle. Such a radius reveals a dynamic mechanism of CPT-violation, i.e., both spontaneous symmetry breaking and Majorana-Dirac neutrino confusion. We show that the time-dependent geometric phase can be used to find the neutrino nature and observe the CPT-violation because it is strongly enhanced under the neutrino propagation. We further show that the time-dependent geometric phase can be easily detected by simulating the neutrino oscillation based on fluctuating magnetic fields in nuclear ...

  3. Adverse immunoregulatory effects of 5FU and CPT11 chemotherapy on myeloid-derived suppressor cells and colorectal cancer outcomes.

    Science.gov (United States)

    Kanterman, Julia; Sade-Feldman, Moshe; Biton, Moshe; Ish-Shalom, Eliran; Lasry, Audrey; Goldshtein, Aviya; Hubert, Ayala; Baniyash, Michal

    2014-11-01

    Colorectal cancer is associated with chronic inflammation and immunosuppression mediated by myeloid-derived suppressor cells (MDSC). Although chemotherapy reduces tumor burden at early stages, it tends to have limited effect on a progressive disease, possibly due to adverse effects on the immune system in dictating disease outcome. Here, we show that patients with advanced colorectal cancer display enhanced MDSC levels and reduced CD247 expression and that some conventional colorectal cancer chemotherapy supports the immunosuppressive tumor microenvironment. A FOLFOX combined therapy reduced immunosuppression, whereas a FOLFIRI combined therapy enhanced immunosuppression. Mechanistic studies in a colorectal cancer mouse model revealed that FOLFIRI-like therapy including the drugs CPT11 and 5-fluorouracil (5FU) damaged host immunocompetence in a manner that limits treatment outcomes. CPT11 blocked MDSC apoptosis and myeloid cell differentiation, increasing MDSC immunosuppressive features and mouse mortality. In contrast, 5FU promoted immune recovery and tumor regression. Thus, CPT11 exhibited detrimental immunoregulatory effects that offset 5FU benefits when administered in combination. Our results highlight the importance of developing therapeutic regimens that can target both the immune system and tumor towards improved personalized treatments for colorectal cancer.

  4. Search for CPT and Lorentz Violation in B0-B0bar Oscillations with Inclusive Dilepton Events

    CERN Document Server

    Aubert, B; Bóna, M; Boutigny, D; Couderc, F; Karyotakis, Yu; Lees, J P; Poireau, V; Tisserand, V; Zghiche, A; Graugès-Pous, E; Palano, A; Chen, J C; Qi, N D; Rong, G; Wang, P; Zhu, Y S; Eigen, G; Ofte, I; Stugu, B; Abrams, G S; Battaglia, M; Brown, D N; Button-Shafer, J; Cahn, R N; Charles, E; Gill, M S; Groysman, Y; Jacobsen, R G; Kadyk, J A; Kerth, L T; Kolomensky, Yu G; Kukartsev, G; Lynch, G; Mir, L M; Orimoto, T J; Pripstein, M; Roe, N A; Ronan, M T; Wenzel, W A; Del Amo-Sánchez, P; Barrett, M; Ford, K E; Hart, A J; Harrison, T J; Hawkes, C M; Morgan, S E; Watson, A T; Held, T; Koch, H; Lewandowski, B; Pelizaeus, M; Peters, K; Schröder, T; Steinke, M; Boyd, J T; Burke, J P; Cottingham, W N; Walker, D; Asgeirsson, D J; Çuhadar-Dönszelmann, T; Fulsom, B G; Hearty, C; Knecht, N S; Mattison, T S; McKenna, J A; Khan, A; Kyberd, P; Saleem, M; Sherwood, D J; Teodorescu, L; Blinov, V E; Bukin, A D; Druzhinin, V P; Golubev, V B; Onuchin, A P; Serednyakov, S I; Skovpen, Yu I; Solodov, E P; Todyshev, K Yu; Best, D S; Bondioli, M; Bruinsma, M; Chao, M; Curry, S; Eschrich, I; Kirkby, D; Lankford, A J; Lund, P; Mandelkern, M A; Mommsen, R K; Röthel, W; Stoker, D P; Abachi, S; Buchanan, C; Foulkes, S D; Gary, J W; Long, O; Shen, B C; Wang, K; Zhang, L; Hadavand, H K; Hill, E J; Paar, H P; Rahatlou, S; Sharma, V; Berryhill, J W; Campagnari, C; Cunha, A; Dahmes, B; Hong, T M; Kovalskyi, D; Richman, J D; Beck, T W; Eisner, A M; Flacco, C J; Heusch, C A; Kroseberg, J; Lockman, W S; Nesom, G; Schalk, T; Schumm, B A; Seiden, A; Spradlin, P; Williams, D C; Wilson, M G; Albert, J; Chen, E; Dvoretskii, A; Fang, F; Hitlin, D G; Narsky, I; Piatenko, T; Porter, F C; Ryd, A; Samuel, A; Mancinelli, G; Meadows, B T; Mishra, K; Sokoloff, M D; Blanc, F; Bloom, P C; Chen, S; Ford, W T; Hirschauer, J F; Kreisel, A; Nagel, M; Nauenberg, U; Olivas, A; Ruddick, W O; Smith, J G; Ulmer, K A; Wagner, S R; Zhang, J; Chen, A; Eckhart, E A; Soffer, A; Toki, W H; Wilson, R J; Winklmeier, F; Zeng, Q; Altenburg, D D; Feltresi, E; Hauke, A; Jasper, H; Merkel, J; Petzold, A; Spaan, B; Brandt, T; Klose, V; Lacker, H M; Mader, W F; Nogowski, R; Schubert, J; Schubert, K R; Schwierz, R; Sundermann, J E; Volk, A; Bernard, D; Bonneaud, G R; Latour, E; Thiebaux, C; Verderi, M; Clark, P J; Gradl, W; Muheim, F; Playfer, S; Robertson, A I; Xie, Y; Andreotti, M; Bettoni, D; Bozzi, C; Calabrese, R; Cibinetto, G; Luppi, E; Negrini, M; Petrella, A; Piemontese, L; Prencipe, E; Anulli, F; Baldini-Ferroli, R; Calcaterra, A; De Sangro, R; Finocchiaro, G; Pacetti, S; Patteri, P; Peruzzi, I M; Piccolo, M; Rama, M; Zallo, A; Buzzo, A; Capra, R; Contri, R; Lo Vetere, M; Macri, M M; Monge, M R; Passaggio, S; Patrignani, C; Robutti, E; Santroni, A; Tosi, S; Brandenburg, G; Chaisanguanthum, K S; Morii, M; Wu, J; Dubitzky, R S; Marks, J; Schenk, S; Uwer, U; Bard, D J; Bhimji, W; Bowerman, D A; Dauncey, P D; Egede, U; Flack, R L; Nash, J A; Nikolich, M B; Panduro-Vazquez, W; Behera, P K; Chai, X; Charles, M J; Mallik, U; Meyer, N T; Ziegler, V; Cochran, J; Crawley, H B; Dong, L; Eyges, V; Meyer, W T; Prell, S; Rosenberg, E I; Rubin, A E; Gritsan, A V; Denig, A G; Fritsch, M; Schott, G; Arnaud, N; Davier, M; Grosdidier, G; Höcker, A; Le Diberder, F R; Lepeltier, V; Lutz, A M; Oyanguren, A; Pruvot, S; Rodier, S; Roudeau, P; Schune, M H; Stocchi, A; Wang, W F; Wormser, G; Cheng, C H; Lange, D J; Wright, D M; Chavez, C A; Forster, I J; Fry, J R; Gabathuler, E; Gamet, R; George, K A; Hutchcroft, D E; Payne, D J; Schofield, K C; Touramanis, C; Bevan, A J; Di Lodovico, F; Menges, W; Sacco, R; Cowan, G; Flächer, H U; Hopkins, D A; Jackson, P S; McMahon, T R; Ricciardi, S; Salvatore, F; Wren, A C; Davis, C L; Allison, J; Barlow, N R; Barlow, R J; Chia, Y M; Edgar, C L; Lafferty, G D; Naisbit, M T; Williams, J C; Yi, J I; Chen, C; Hulsbergen, W D; Jawahery, A; Lae, C K; Roberts, D A; Simi, G; Blaylock, G; Dallapiccola, C; Hertzbach, S S; Li, X; Moore, T B; Saremi, S; Stängle, H; Cowan, R; Sciolla, G; Sekula, S J; Spitznagel, M; Taylor, F; Yamamoto, R K; Kim, H; Mclachlin, S E; Patel, P M; Robertson, S H; Lazzaro, A; Lombardo, V; Palombo, F; Bauer, J M; Cremaldi, L; Eschenburg, V; Godang, R; Kroeger, R; Sanders, D A; Summers, D J; Zhao, H W; Brunet, S; Côté, D; Simard, M; Taras, P; Viaud, F B; Nicholson, H; Cavallo, N; De Nardo, Gallieno; Fabozzi, F; Gatto, C; Lista, L; Monorchio, D; Paolucci, P; Piccolo, D; Sciacca, C; Baak, M A; Raven, G; Snoek, H L; Jessop, C P; LoSecco, J M; Allmendinger, T; Benelli, G; Corwin, L A; Gan, K K; Honscheid, K; Hufnagel, D; Jackson, P D; Kagan, H; Kass, R; Rahimi, A M; Regensburger, J J; Ter-Antonian, R; Wong, Q K; Blount, N L; Brau, J E; Frey, R; Igonkina, O; Kolb, J A; Lu, M; Rahmat, R; Sinev, N B; Strom, D; Strube, J; Torrence, E; Gaz, A; Margoni, M; Morandin, M; Pompili, A; Posocco, M; Rotondo, M; Simonetto, F; Stroili, R; Voci, C; Benayoun, M; Briand, H; Chauveau, J; David, P; Del Buono, L; La Vaissière, C de; Hamon, O; Hartfiel, B L; John, M J J; Leruste, P; Malcles, J; Ocariz, J; Roos, L; Therin, G; Gladney, L; Panetta, J; Biasini, M; Covarelli, R; Angelini, C; Batignani, G; Bettarini, S; Bucci, F; Calderini, G; Carpinelli, M; Cenci, R; Forti, F; Giorgi, M A; Lusiani, A; Marchiori, G; Mazur, M A; Morganti, M; Neri, N; Paoloni, E; Rizzo, G; Walsh, J J; Haire, M; Judd, D; Wagoner, D E; Biesiada, J; Danielson, N; Elmer, P; Lau, Y P; Lü, C; Olsen, J; Smith, A J S; Telnov, A V; Bellini, F; Cavoto, G; D'Orazio, A; Del Re, D; Di Marco, E; Faccini, R; Ferrarotto, F; Ferroni, F; Gaspero, M; Li Gioi, L; Mazzoni, M A; Morganti, S; Piredda, G; Polci, F; Safai-Tehrani, F; Voena, C; Ebert, M; Schröder, H; Waldi, R; Adye, T; De Groot, N; Franek, B; Olaiya, E O; Wilson, F F; Aleksan, R; Emery, S; Gaidot, A; Ganzhur, S F; Hamel de Monchenault, G; Kozanecki, Witold; Legendre, M; Vasseur, G; Yéche, C; Zito, M; Chen, X R; Liu, H; Park, W; Purohit, M V; Wilson, J R; Allen, M T; Aston, D; Bartoldus, R; Bechtle, P; Berger, N; Claus, R; Coleman, J P; Convery, M R; Cristinziani, M; Dingfelder, J C; Dorfan, J; Dubois-Felsmann, G P; Dujmic, D; Dunwoodie, W M; Field, R C; Glanzman, T; Gowdy, S J; Graham, M T; Grenier, P; Halyo, V; Hast, C; Hrynóva, T; Innes, W R; Kelsey, M H; Kim, P; Leith, D W G S; Li, S; Luitz, S; Lüth, V; Lynch, H L; MacFarlane, D B; Marsiske, H; Messner, R; Müller, D R; O'Grady, C P; Ozcan, V E; Perazzo, A; Perl, M; Pulliam, T; Ratcliff, B N; Roodman, A; Salnikov, A A; Schindler, R H; Schwiening, J; Snyder, A; Stelzer, J; Su, D; Sullivan, M K; Suzuki, K; Swain, S K; Thompson, J M; Vavra, J; Van Bakel, N; Weaver, M; Weinstein, A J R; Wisniewski, W J; Wittgen, M; Wright, D H; Yarritu, A K; Yi, K; Young, C C; Burchat, P R; Edwards, A J; Majewski, S A; Petersen, B A; Roat, C; Wilden, L; Ahmed, S; Alam, M S; Bula, R; Ernst, J A; Jain, V; Pan, B; Saeed, M A; Wappler, F R; Zain, S B; Bugg, W; Krishnamurthy, M; Spanier, S M; Eckmann, R; Ritchie, J L; Satpathy, A; Schilling, C J; Schwitters, R F; Izen, J M; Lou, X C; Ye, S; Bianchi, F; Gallo, F; Gamba, D; Bomben, M; Bosisio, L; Cartaro, C; Cossutti, F; Della Ricca, G; Dittongo, S; Lanceri, L; Vitale, L; Azzolini, V; Lopez-March, N; Martínez-Vidal, F; Banerjee, Sw; Bhuyan, B; Brown, C M; Fortin, D; Hamano, K; Kowalewski, R V; Nugent, I M; Roney, J M; Sobie, R J; Back, J J; Harrison, P F; Latham, T E; Mohanty, G B; Pappagallo, M; Band, H R; Chen, X; Cheng, B; Dasu, S; Datta, M; Flood, K T; Hollar, J J; Kutter, P E; Mellado, B; Mihályi, A; Pan, Y; Pierini, M; Prepost, R; Wu, S L; Yu, Z; Neal, H; al, et

    2006-01-01

    We report preliminary results of a search for CPT and Lorentz violation in B0-B0bar oscillations using an inclusive dilepton sample collected by the BABAR experiment at the PEP-II B Factory. Using a sample of 232 million BBbar pairs, we search for time-dependent variations in the complex CPT parameter z = z0 + z1*cos(Omega*t^ + phi) where Omega is the Earth's sidereal frequency and t^ is sidereal time. We measure Im(z0) = (-14.1 +- 7.3(stat) +- 2.4(syst)) x 10E-3, DeltaGamma*Re(z0) = (-7.2 +- 4.1(stat) +- 2.1(syst)) x 10E-3 ps-1, Im(z1) = (-24.0 +- 10.7(stat) +- 5.9(syst)) x 10E-3, and DeltaGamma*Re(z1) = (-18.8 +- 5.5(stat) +- 4.0(syst)) x 10E-3 ps-1, where DeltaGamma is the difference between the decay rates of the neutral B mass eigenstates. The statistical correlation between the measurements of Im(z0) and DeltaGamma*Re(z0) is 76%; between Im(z1) and DeltaGamma*Re(z1) it is 79%. These results are used to evaluate expressions involving coefficients for Lorentz and CPT violation in the general Lorentz-viola...

  5. Assuming a Pharmacy Organization Leadership Position: A Guide for Pharmacy Leaders.

    Science.gov (United States)

    Shay, Blake; Weber, Robert J

    2015-11-01

    Important and influential pharmacy organization leadership positions, such as president, board member, or committee chair, are volunteer positions and require a commitment of personal and professional time. These positions provide excellent opportunities for leadership development, personal promotion, and advancement of the profession. In deciding to assume a leadership position, interested individuals must consider the impact on their personal and professional commitments and relationships, career planning, employer support, current and future department projects, employee support, and personal readiness. This article reviews these factors and also provides an assessment tool that leaders can use to determine their readiness to assume leadership positions. By using an assessment tool, pharmacy leaders can better understand their ability to assume an important and influential leadership position while achieving job and personal goals.

  6. Preparation, characterization, and cytotoxicity of CPT/Fe2O3-embedded PLGA ultrafine composite fibers: a synergistic approach to develop promising anticancer material

    Directory of Open Access Journals (Sweden)

    Amna T

    2012-03-01

    Full Text Available Touseef Amna1, M Shamshi Hassan2, Ki-Taek Nam2, Yang You Bing3, Nasser AM Barakat2, Myung-Seob Khil2, Hak Yong Kim1,21Center for Healthcare Technology Development, 2Department of Organic Materials and Fiber Engineering, Chonbuk National University, Jeonju, Korea; 3Animal Science and Technology College, Henan University of Science and Technology, Luoyang, ChinaAbstract: The aim of this study was to fabricate camptothecin/iron(III oxide (CPT/Fe2O3-loaded poly(D,L-lactide-co-glycolide (PLGA composite mats to modulate the CPT release and to improve the structural integrity and antitumor activity of the released drug. The CPT/ Fe2O3-loaded PLGA ultrafine fibers were prepared for the first time by electrospinning a composite solution of CPT/Fe2O3 and neat PLGA (4 weight percent. The physicochemical characterization of the electrospun composite mat was carried out by scanning electron microscopy, energy dispersive X-ray spectroscopy, electron probe microanalysis, thermogravimetry, transmission electron microscopy, ultraviolet-visible spectroscopy, and X-ray diffraction pattern. The medicated composite fibers were evaluated for their cytotoxicity on C2C12 cells using Cell Counting Kit-8 assay (Sigma-Aldrich Corporation, St Louis, MO. The in vitro studies indicated a slow and prolonged release over a period of 96 hours with mild initial burst. Scanning electron microscopy, thermogravimetry, and X-ray diffraction studies confirmed the interaction of CPT/Fe2O3 with the PLGA matrix and showed that the crystallinity of CPT decreased after loading. Incorporation of CPT in the polymer media affected both the morphology and the size of the CPT/Fe2O3-loaded PLGA composite fibers. Electron probe microanalysis and energy dispersive X-ray spectroscopy results confirmed well-oriented composite ultrafine fibers with good incorporation of CPT/Fe2O3. The cytotoxicity results illustrate that the pristine PLGA did not exhibit noteworthy cytotoxicity; conversely, the CPT

  7. A URI 4-NODE QUADRILATERAL ELEMENT BY ASSUMED STRAIN METHOD FOR NONLINEAR PROBLEMS

    Institute of Scientific and Technical Information of China (English)

    WANG Jinyan; CHEN Jun; LI Minghui

    2004-01-01

    In this paper one-point quadrature "assumed strain" mixed element formulation based on the Hu-Washizu variational principle is presented. Special care is taken to avoid hourglass modes and volumetric locking as well as shear locking. The assumed strain fields are constructed so that those portions of the fields which lead to volumetric and shear locking phenomena are eliminated by projection, while the implementation of the proposed URI scheme is straightforward to suppress hourglass modes. In order to treat geometric nonlinearities simply and efficiently, a corotational coordinate system is used. Several numerical examples are given to demonstrate the performance of the suggested formulation, including nonlinear static/dynamic mechanical problems.

  8. Numerical Simulation of Wind Fields Calculated from Assumed Mode S Data Link Inputs.

    Science.gov (United States)

    1982-01-01

    U) JAN 82 A CARRO . R C G0FF UNLSIIDFAA/CT-a/?, FAA-RD-81/100 N I31 uuuHu.. 2 DOT/FAA/RD81/lOO Numerical Simulation of Wind Fields Calculated From...Assumed Mode S Data Link Inputs Anthony Carro R. Craig Goff ~IIE~Prepared By FAA Technical Center Atlantic City Airport, N.J. 08405 January 1982 Final...FROM January 1982 ASSUMED MODE S DATA LINK INPUTS 6. Performing Organization Code 8. Performing Organization Report No. 7. Author{ s) Anthony Carro and K

  9. How Public High School Students Assume Cooperative Roles to Develop Their EFL Speaking Skills

    Directory of Open Access Journals (Sweden)

    Julie Natalie Parra Espinel

    2010-12-01

    Full Text Available This study describes an investigation we carried out in order to identify how the specific roles that 7th grade public school students assumed when they worked cooperatively were related to their development of speaking skills in English. Data were gathered through interviews, field notes, students’ reflections and audio recordings. The findings revealed that students who were involved in cooperative activities chose and assumed roles taking into account preferences, skills and personality traits. In the same manner, when learners worked together, their roles were affected by each other and they put into practice some social strategies with the purpose of supporting their embryonic speaking development.

  10. Optimal Control for TB disease with vaccination assuming endogeneous reactivation and exogeneous reinfection

    Science.gov (United States)

    Anggriani, N.; Wicaksono, B. C.; Supriatna, A. K.

    2016-06-01

    Tuberculosis (TB) is one of the deadliest infectious disease in the world which caused by Mycobacterium tuberculosis. The disease is spread through the air via the droplets from the infectious persons when they are coughing. The World Health Organization (WHO) has paid a special attention to the TB by providing some solution, for example by providing BCG vaccine that prevent an infected person from becoming an active infectious TB. In this paper we develop a mathematical model of the spread of the TB which assumes endogeneous reactivation and exogeneous reinfection factors. We also assume that some of the susceptible population are vaccinated. Furthermore we investigate the optimal vaccination level for the disease.

  11. Combination treatment with TRA-8 anti death receptor 5 antibody and CPT-11 induces tumor regression in an orthotopic model of pancreatic cancer.

    Science.gov (United States)

    DeRosier, Leo Christopher; Buchsbaum, Donald J; Oliver, Patsy G; Huang, Zhi-Qiang; Sellers, Jeffrey C; Grizzle, William E; Wang, Wenquan; Zhou, Tong; Zinn, Kurt R; Long, Joshua W; Vickers, Selwyn M

    2007-09-15

    Evaluate the response of human pancreatic cancer cell lines and orthotopic tumors to TRA-8, an agonistic antibody to death receptor 5, in combination with irinotecan (CPT-11). MIA PaCa-2 and S2VP10 cells were treated with TRA-8 and/or CPT 11. Cell viability was determined by ATP assay. JC-1 mitochondrial depolarization and Annexin V assays confirmed cell death by apoptosis. Immunoblotting was used to evaluate protein changes. MIA PaCa-2 cells were injected into the pancreas of severe combined immunodeficient mice. Mice underwent abdominal ultrasound to quantitate tumor size before and after treatment with twice weekly injections of 200 microg TRA-8 and/or 25 mg/kg CPT-11 for one or two treatment cycles, each lasting 2 weeks. MIA PaCa-2 cells were more sensitive to TRA-8 and showed additive cytotoxicity, whereas S2VP10 cells showed synergistic cytotoxicity when treated with TRA-8 and CPT-11. Cell death occurred via apoptosis with increased cleavage of caspase-3, caspase-8, and caspase-9 and proapoptotic proteins Bid and poly(ADP)ribose polymerase after combination treatment compared with either agent alone. XIAP and Bcl-XL inhibitors of apoptosis were down-regulated. After a single cycle of in vivo combination therapy, tumor sizes had diminished significantly (PTRA-8; and there was a 50-day increase in survival with combination treatment over untreated controls (P=0.0002), 30 days over TRA-8, and a 36-day increase over CPT-11 monotherapy (P=0.0003). With two cycles of TRA-8/CPT-11 treatment, mean survival time increased significantly (PTRA-8 or CPT-11 (76, 121, or 108 days, respectively). Combination TRA-8 and CPT-11 therapy produced enhanced cytotoxicity and survival in the MIA PaCa-2 orthotopic model of pancreatic cancer.

  12. The Working Principle of Deinked Pulp CPT Flotation Column And Industrialization%脱墨浆渣CPT浮选柱的工作原理及工业化

    Institute of Scientific and Technical Information of China (English)

    孙丽英; 李琼砚; 陈倩

    2011-01-01

    分析了加拿大CPT浮选柱的工作原理、自动控制系统,并分析了脱墨浆渣浮选柱工业化的难点。%Abstract. The thesis discusses the working principle of deinked pulp CPT flotation column, automatic control system, Meanwhile discussing the difficulties in developing industry in deinked pulp CPT flotation column.

  13. Determination of CP and CPT violation parameters in the neutral kaon system using the Bell-Steinberger relation and data from the KLOE experiment

    CERN Document Server

    D'Ambrosio, G; Antonelli, A; Antonelli, M; Bacci, C; Beltrame, P; Bencivenni, G; Bertolucci, S; Bini, C; Bloise, C; Bocchetta, S; Bocci, V; Bossi, F; Bowring, D; Branchini, P; Caloi, R; Campana, P; Capon, G; Capussela, T; Ceradini, F; Chi, S; Chiefari, G; Ciambrone, P; Conetti, S; De Lucia, E; De Santis, A; De Simone, P; De Zorzi, G; Dell'Agnello, S; Denig, A; Di Domenico, A; Di Donato, C; Di Falco, a S; Di Micco, B; Doria, A; Dreucci, M; Felici, G; Ferrari, A; Ferrer, M L; Finocchiaro, G; Fiore, S; Forti, C; Franzini, P; Gatti, C; Gauzzi, P; Giovannella, S; Gorini, E; Graziani, E; Incagli, M; Kluge, W; Kulikov, V; Lacava, F; Lanfranchi, G; Lee-Franzini, J; Leone, D; Martini, M; Massarotti, P; Mei, W; Meola, S; Miscetti, S; Moulson, M; Müller, S; Murtas, F; Napolitano, M; Nguyen, F; Palutan, M; Pasqualucci, E; Passeri, A; Patera, V; Perfetto, F; Pontecorvo, L; Primavera, M; Santangelo, P; Santovetti, E; Saracino, G; Sciascia, B; Sciubba, A; Scuri, F; Sfiligoi, I; Sibidanov, A L; Spadaro, T; Testa, M; Tortora, L; Valente, P; Valeriani, B; Venanzoni, G; Veneziano, S; Ventura, A; Versaci, R; Xu, G; D'Ambrosio, G; Isidori, Gino

    2006-01-01

    We present an improved determination of the CP and CPT violation parameters Re(epsilon) and Im(delta) based on the unitarity condition (Bell-Steinberger relation) and on recent results from the KLOE experiment. We find Re(epsilon) = (159.6 \\pm 1.3)10^-5 and Im(delta) = (0.4 \\pm 2.1)10^-5, consistent with no CPT violation.

  14. Comparison of ELCAP data with lighting and equipment load levels and profiles assumed in regional models

    Energy Technology Data Exchange (ETDEWEB)

    Taylor, Z.T.; Pratt, R.G.

    1990-09-01

    The analysis in this report was driven by two primary objectives: to determine whether and to what extent the lighting and miscellaneous equipment electricity consumption measured by metering in real buildings differs from the levels assumed in the various prototypes used in power forecasting; and to determine the reasons for those differences if, in fact, differences were found. 13 refs., 47 figs., 4 tabs.

  15. On the Estimation of Complex Speech DFT Coefficients Without Assuming Independent Real and Imaginary Parts

    NARCIS (Netherlands)

    Erkelens, J.S.; Hendriks, R.C.; Heusdens, R.

    2008-01-01

    This letter considers the estimation of speech signals contaminated by additive noise in the discrete Fourier transform (DFT) domain. Existing complex-DFT estimators assume independency of the real and imaginary parts of the speech DFT coefficients, although this is not in line with measurements. In

  16. Application of the Perturbation Method for Determination of Eigenvalues and Eigenvectors for the Assumed Static Strain

    Directory of Open Access Journals (Sweden)

    Major Izabela

    2014-12-01

    Full Text Available The paper presents the perturbation method which was used for computation of eigenvalues and eigenvectors for the assumed homogeneous state of strain in the hyperelastic Murnaghan material. The values calculated might be used for determination of the rate of propagation of unit vectors of wave amplitude for other non-linear

  17. ASSUMED OXYGEN-CONSUMPTION BASED ON CALCULATION FROM DYE DILUTION CARDIAC-OUTPUT - AN IMPROVED FORMULA

    NARCIS (Netherlands)

    BERGSTRA, A; VANDIJK, RB; HILLEGE, HL; LIE, KI; MOOK, GA

    1995-01-01

    This study was performed because of observed differences between dye dilution cardiac output and the Fick cardiac output, calculated from estimated oxygen consumption according to LaFarge and Miettinen, and to find a better formula for assumed oxygen consumption. In 250 patients who underwent left a

  18. Partial sums of the M\\"obius function in arithmetic progressions assuming GRH

    CERN Document Server

    Halupczok, Karin

    2011-01-01

    We consider Mertens' function M(x,q,a) in arithmetic progression, Assuming the generalized Riemann hypothesis (GRH), we show an upper bound that is uniform for all moduli which are not too large. For the proof, a former method of K. Soundararajan is extended to L-series.

  19. A Model for Teacher Effects from Longitudinal Data without Assuming Vertical Scaling

    Science.gov (United States)

    Mariano, Louis T.; McCaffrey, Daniel F.; Lockwood, J. R.

    2010-01-01

    There is an increasing interest in using longitudinal measures of student achievement to estimate individual teacher effects. Current multivariate models assume each teacher has a single effect on student outcomes that persists undiminished to all future test administrations (complete persistence [CP]) or can diminish with time but remains…

  20. Testing CPT conservation using the NuMI neutrino beam with the MINOS experiment

    Energy Technology Data Exchange (ETDEWEB)

    Auty, David John [Univ. of Sussex, Brighton (United Kingdom)

    2010-03-01

    The MINOS experiment was designed to measure neutrino oscillation parameters with muon neutrinos. It achieves this by measuring the neutrino energy spectrum and flavor composition of the man-made NuMI neutrino beam 1km after the beam is formed and again after 735 km. By comparing the two spectra it is possible to measure the oscillation parameters. The NuMI beam is made up of 7.0%$\\bar{v}$μ, which can be separated from the vμ because the MINOS detectors are magnetized. This makes it possible to study $\\bar{v}$μ oscillations separately from those of muon neutrinos, and thereby test CPT invariance in the neutrino sector by determining the $\\bar{v}$μ oscillation parameters and comparing them with those for vμ, although any unknown physics of the antineutrino would appear as a difference in oscillation parameters. Such a test has not been performed with beam $\\bar{v}$μ before. It is also possible to produce an almost pure $\\bar{v}$μ beam by reversing the current through the magnetic focusing horns of the NuMI beamline, thereby focusing negatively, instead of positively charged particles. This thesis describes the analysis of the 7% $\\bar{v}$μ component of the forward horn current NuMI beam. The $\\bar{v}$μ of a data sample of 3.2 x 10{sup 20} protons on target analysis found 42 events, compared to a CPT conserving prediction of 58.3-7.6+7.6(stat.)-3.6+3.6(syst.) events. This corresponds to a 1.9 σ deficit, and a best fit value of Δ$\\bar{m}$322 = 18 x 10-3 eV2 and sin2 2$\\bar{θ}$23 = 0.55. This thesis focuses particularly on the selection of $\\bar{v}$μ events, and investigates possible improvements of the selection algorithm. From this a different selector was chosen, which corroborated the findings of the original selector. The

  1. Planar version of the CPT-even gauge sector of the standard model extension

    Energy Technology Data Exchange (ETDEWEB)

    Ferreira Junior, Manoel M.; Casana, Rodolfo; Gomes, Adalto Rodrigues; Carvalho, Eduardo S. [Universidade Federal do Maranhao (UFMA), Sao Luis, MA (Brazil). Dept. de Fisica

    2011-07-01

    The CPT-even abelian gauge sector of the Standard Model Extension is represented by the Maxwell term supplemented by (K{sub F} ){sub {mu}}{nu}{rho}{sigma} F{sup {mu}}{nu} F{sup {rho}}{sigma}, where the Lorentz-violating background tensor, (K{sub F} ){sub {mu}}{nu}{rho}{sigma}, possesses the symmetries of the Riemann tensor and a double null trace, which renders nineteen independent components. From these ones, ten components yield birefringence while nine are nonbirefringent ones. In the present work, we examine the planar version of this theory, obtained by means of a typical dimensional reduction procedure to (1 + 2) dimensions. We obtain a kind of planar scalar electrodynamics, which is composed of a gauge sector containing six Lorentz-violating coefficients, a scalar field endowed with a noncanonical kinetic term, and a coupling term that links the scalar and gauge sectors. The dispersion relation is exactly determined, revealing that the six parameters related to the pure electromagnetic sector do not yield birefringence at any order. In this model, the birefringence may appear only as a second order effect associated with the coupling tensor linking the gauge and scalar sectors.The equations of motion are written and solved in the stationary regime. The Lorentz-violating parameters do not alter the asymptotic behavior of the fields but induce an angular dependence not observed in the Maxwell planar theory. The energy-momentum tensor was evaluated as well, revealing that the theory presents energy stability. (author)

  2. Finite temperature CPT-even electrodynamics of the standard model extension

    Energy Technology Data Exchange (ETDEWEB)

    Casana, Rodolfo; Ferreira Junior, Manoel M.; Rodrigues, Josberg S.; Silva, Madson R.O. [Universidade Federal do Maranhao (UFMA), Sao Luiz, MA (Brazil)

    2009-07-01

    Full text. In this work, we examine the finite temperature properties of the non-birefringent coefficients of the CPT- even and Lorentz-invariance-violating (LIV) electrodynamics of the standard model extension, represented by the term W{sub {mu}}{sub {nu}}{sub {alpha}}{sub {beta}}F{sub {mu}}{sub {nu}}F{sub {alpha}}{sub {beta}}. We begin analyzing the Hamiltonian structure following the Diracs procedure for constrained systems. The partition function for this model in the functional integral formalism is properly written and explicitly carried out both for the parity-odd and parity-even sectors of the tensor WW{sub {mu}}{sub {nu}}{sub {alpha}}{sub {beta}}i. The modified partition function is a power of the Maxwell partition function. It is observed that the LIV coefficients induce an anisotropy in the black body energy density angular distribution in two cases of interest. The Planck radiation law, however, retains its frequency dependence and the Stefan-Boltzmann law keeps the usual form, except for a change in the Stefan-Boltzmann constant by a factor containing the LIV contributions. Since the LIV coefficients are constrained by very stringent upper bounds, the lower order non-null LIV contribution for the Maxwell thermodynamics would give a good information about the thermodynamical properties of the non birefringent sector the model. It is clearly observed for the parity-odd sector, where the lower correction is quadratic in the LIV parameter {kappa}. On the other hand, in the parity-even sector, the isotropic contribution gives a linear correction in n, whereas the anisotropic contribution coming from the matrix {kappa}{sub e-} only is manifest at fourth order. Hence, the pure anisotropic contribution is irrelevant when compared with the isotropic one. (author)

  3. Uniform convergence and a posteriori error estimation for assumed stress hybrid finite element methods

    CERN Document Server

    Yu, Guozhu; Carstensen, Carsten

    2011-01-01

    Assumed stress hybrid methods are known to improve the performance of standard displacement-based finite elements and are widely used in computational mechanics. The methods are based on the Hellinger-Reissner variational principle for the displacement and stress variables. This work analyzes two existing 4-node hybrid stress quadrilateral elements due to Pian and Sumihara [Int. J. Numer. Meth. Engng, 1984] and due to Xie and Zhou [Int. J. Numer. Meth. Engng, 2004], which behave robustly in numerical benchmark tests. For the finite elements, the isoparametric bilinear interpolation is used for the displacement approximation, while different piecewise-independent 5-parameter modes are employed for the stress approximation. We show that the two schemes are free from Poisson-locking, in the sense that the error bound in the a priori estimate is independent of the relevant Lame constant $\\lambda$. We also establish the equivalence of the methods to two assumed enhanced strain schemes. Finally, we derive reliable ...

  4. COUPLING OF ASSUMED STRESS FINITE ELEMENT AND BOUNDARY ELEMENT METHODS WITH STRESS-TRACTION EQUILIBRIUM

    Institute of Scientific and Technical Information of China (English)

    GUZELBEY Ibrahim H.; KANBER Bahattin; AKPOLAT Abdullah

    2004-01-01

    In this study, the stress based finite element method is coupled with the boundary element method in two different ways. In the first one, the ordinary distribution matrix is used for coupling. In the second one, the stress traction equilibrium is used at the interface line of both regions as a new coupling process. This new coupling procedure is presented without a distribution matrix. Several case studies are solved for the validation of the developed coupling procedure. The results of case studies are compared with the distribution matrix coupling, displacement based finite element method, assumed stress finite element method, boundary element method, ANSYS and analytical results whenever possible. It is shown that the coupling of the stress traction equilibrium with assumed stress finite elements gives as accurate results as those by the distribution matrix coupling.

  5. Three-dimensional base isolation system for assumed FBR reactor building

    Energy Technology Data Exchange (ETDEWEB)

    Tokuda, N.; Kashiwazaki, A.; Omata, I. [Ishikawajima-Harima Heavy Industries Co. Ltd., Yokohama (Japan); Ohnaka, T. [Yokohama Rubber Co. Ltd., Hiratsuka (Japan)

    1995-12-31

    A three-dimensional base isolation system for an assumed FBR reactor building is proposed, where a horizontally isolated building by laminated rubber bearings is supported by an intermediate slab which is vertically isolated by using air springs of high pressure. From some fundamental investigations on the above system, it is concluded that the system can be sufficiently practical by using the current industrially available techniques. (author). 4 refs., 6 figs., 1 tab.

  6. Polysaccharopeptides derived from Coriolus versicolor potentiate the S-phase specific cytotoxicity of Camptothecin (CPT on human leukemia HL-60 cells

    Directory of Open Access Journals (Sweden)

    Jiang Pingping

    2010-04-01

    Full Text Available Abstract Background Polysaccharopeptide (PSP from Coriolus versicolor (Yunzhi is used as a supplementary cancer treatment in Asia. The present study aims to investigate whether PSP pre-treatment can increase the response of the human leukemia HL-60 cells to apoptosis induction by Camptothecin (CPT. Methods We used bivariate bromodeoxyuridine/propidium iodide (BrdUrd/PI flow cytometry analysis to measure the relative movement (RM of the BrdUrd positively labeled cells and DNA synthesis time (Ts on the HL-60 cell line. We used annexin V/PI flow cytometry analysis to quantify the viable, necrotic and apoptotic cells. The expression of cyclin E and cyclin B1 was determined with annexin V/PI flow cytometry and western blotting. Human peripheral blood mononuclear cells were used to test the cytotoxicity of PSP and CPT. Results PSP reduced cellular proliferation; inhibited cells progression through both S and G2 phase, reduced 3H-thymidine uptake and prolonged DNA synthesis time (Ts in HL-60 cells. PSP-pretreated cells enhanced the cytotoxicity of CPT. The sensitivity of cells to the cytotoxic effects of CPT was seen to be the highest in the S-phase and to a small extent of the G2 phase of the cell cycle. On the other hand, no cell death (measured by annexin V/PI was evident with the normal human peripheral blood mononuclear cells with treatment of either PSP or CPT. Conclusion The present study shows that PSP increases the sensitization of the HL-60 cells to undergo effective apoptotic cell death induced by CPT. The pattern of sensitivity of cancer cells is similar to that of HL-60 cells. PSP rapidly arrests and/or kills cells in S-phase and did not interfere with the anticancer action of CPT. PSP is a potential adjuvant to treat human leukemia as rapidly proliferating tumors is characterized by a high proportion of S-phase cells.

  7. Dopamine D1 receptor activation improves PCP-induced performance disruption in the 5C-CPT by reducing inappropriate responding.

    Science.gov (United States)

    Barnes, S A; Young, J W; Bate, S T; Neill, J C

    2016-03-01

    Attentional deficits contribute significantly to the functional disability of schizophrenia patients. The 5-choice continuous performance test (5C-CPT) measures attention in mice, rats, and humans, requiring the discrimination of trial types that either require a response or the inhibition of a response. The 5C-CPT, one version of human continuous performance tests (CPT), enables attentional testing in rodents in a manner consistent with humans. Augmenting the prefrontal cortical dopaminergic system has been proposed as a therapeutic target to attenuate the cognitive disturbances associated with schizophrenia. Using translational behavioural tasks in conjunction with inducing conditions relevant to schizophrenia pathophysiology enable the assessment of pro-attentive properties of compounds that augment dopaminergic activity. Here, using a repeated phencyclidine (PCP) treatment regimen and the 5C-CPT paradigm, we assess the pro-attentive properties of SKF 38393, a dopamine D1 receptor agonist, in rats. We show that repeated PCP treatment induces robust deficits in 5C-CPT performance indicative of impaired attention. Pre-treatment with SKF 38393 partially attenuates the PCP-induced deficits in 5C-CPT performance by reducing false alarm responding and increasing response accuracy. Impaired target detection was still evident in SKF 38393-treated rats however. Thus, augmentation of the dopamine D1 system improves PCP-induces deficits in 5C-CPT performance by selectively reducing aspects of inappropriate responding. These findings provide evidence to support the hypothesis that novel therapies targeting the dopamine D1 receptor system could improve aspects of attentional deficits in schizophrenia patients. Copyright © 2015 Elsevier B.V. All rights reserved.

  8. Search for CPT and Lorentz Violation in B0-B0bar Oscillations with Inclusive Dilepton Events

    Energy Technology Data Exchange (ETDEWEB)

    Aubert, B.

    2006-09-26

    We report preliminary results of a search for CPT and Lorentz violation in B{sup 0}-{bar B}{sup 0} oscillations using an inclusive dilepton sample collected by the BABAR experiment at the PEP-II B Factory. Using a sample of 232 million B{bar B} pairs, we search for time-dependent variations in the complex CPT parameter z = z{sub 0} +z{sub 1} cos ({Omega}{cflx t} + {phi}) where {Omega} is the Earth's sidereal frequency and {cflx t} is sidereal time. We measure Imz{sub 0} = (-14.1 {+-} 7.3(stat.) {+-} 2.4(syst.)) x 10{sup -3}, {Delta}{Lambda} x Rez{sub 0} = (-7.2 {+-} 4.1(stat.) {+-} 2.1(syst.)) x 10{sup -3} ps{sup -1}, Im z{sub 1} = (-24.0 {+-} 10.7(stat.) {+-} 5.9(syst.)) x 10{sup -3}, and {Delta}{Lambda} x Re z{sub 1} = (-18.8 {+-} 5.5(stat.) {+-} 4.0(syst.)) x 10{sup -3} ps{sup -1}, where {Delta}{Lambda} is the difference between the decay rates of the neutral B mass eigenstates. The statistical correlation between the measurements of Imz{sub 0} and {Delta}{Lambda} x Rez{sub 0} is 76%; between Imz{sub 1} and {Delta}{Lambda} x Rez{sub 1} it is 79%. These results are used to evaluate expressions involving coefficients for Lorentz and CPT violation in the general Lorentz-violating standard-model extension. In a complementary approach, we examine the spectral power of periodic variations in z over a wide range of frequencies and find no significant signal.

  9. High fructose consumption induces DNA methylation at PPARα and CPT1A promoter regions in the rat liver

    Energy Technology Data Exchange (ETDEWEB)

    Ohashi, Koji [Department of Clinical Biochemistry, Fujita Health University School of Health Sciences, Toyoake (Japan); Munetsuna, Eiji [Department of Biochemistry, Fujita Health University School of Medicine, Toyoake (Japan); Yamada, Hiroya, E-mail: hyamada@fujita-hu.ac.jp [Department of Hygiene, Fujita Health University School of Medicine, Toyoake (Japan); Ando, Yoshitaka [Department of Joint Research Laboratory of Clinical Medicine, Fujita Health University Hospital, Toyoake (Japan); Yamazaki, Mirai; Taromaru, Nao; Nagura, Ayuri; Ishikawa, Hiroaki [Department of Clinical Biochemistry, Fujita Health University School of Health Sciences, Toyoake (Japan); Suzuki, Koji [Department of Public Health, Fujita Health University School of Health Sciences, Toyoake (Japan); Teradaira, Ryoji [Department of Clinical Biochemistry, Fujita Health University School of Health Sciences, Toyoake (Japan); Hashimoto, Shuji [Department of Hygiene, Fujita Health University School of Medicine, Toyoake (Japan)

    2015-12-04

    DNA methylation status is affected by environmental factors, including nutrition. Fructose consumption is considered a risk factor for the conditions that make up metabolic syndrome such as dyslipidemia. However, the pathogenetic mechanism by which fructose consumption leads to metabolic syndrome is unclear. Based on observations that epigenetic modifications are closely related to induction of metabolic syndrome, we hypothesized that fructose-induced metabolic syndrome is caused by epigenetic alterations. Male SD rats were designated to receive water or 20% fructose solution for 14 weeks. mRNA levels for peroxisome proliferator-activated receptor alpha (PPARα) and carnitine palmitoyltransferase 1A (CPT1A) was analyzed using Real-time PCR. Restriction digestion and real-time PCR (qAMP) was used for the analysis of DNA methylation status. Hepatic lipid accumulation was also observed by fructose intake. Fructose feeding also significantly decreased mRNA levels for PPARα and CPT1A. qAMP analysis demonstrated the hypermethylation of promoter regions of PPARα and CTP1A genes. Fructose-mediated attenuated gene expression may be mediated by alterations of DNA methylation status, and pathogenesis of metabolic syndrome induced by fructose relates to DNA methylation status. - Highlights: • No general consensus has been reached regarding the molecular mechanisms of the pathogenesis of fructose-induced diseases. • Significant increase in hepatic total methylation level was observed after fructose-supplemented feeding. • Fructose feeding significantly decreased mRNA levels for PPARα and CPT1A. • qAMP analysis demonstrated the hypermethylation of promoter regions of PPARα and CTP1A genes. • Fructose-mediated attenuated gene expression may be mediated by alterations of DNA methylation status in rat liver.

  10. Virtual-reality-based attention assessment of ADHD: ClinicaVR: Classroom-CPT versus a traditional continuous performance test.

    Science.gov (United States)

    Neguț, Alexandra; Jurma, Anda Maria; David, Daniel

    2017-08-01

    Virtual-reality-based assessment may be a good alternative to classical or computerized neuropsychological assessment due to increased ecological validity. ClinicaVR: Classroom-CPT (VC) is a neuropsychological test embedded in virtual reality that is designed to assess attention deficits in children with attention deficit hyperactivity disorder (ADHD) or other conditions associated with impaired attention. The present study aimed to (1) investigate the diagnostic validity of VC in comparison to a traditional continuous performance test (CPT), (2) explore the task difficulty of VC, (3) address the effect of distractors on the performance of ADHD participants and typically-developing (TD) controls, and (4) compare the two measures on cognitive absorption. A total of 33 children diagnosed with ADHD and 42 TD children, aged between 7 and 13 years, participated in the study and were tested with a traditional CPT or with VC, along with several cognitive measures and an adapted version of the Cognitive Absorption Scale. A mixed multivariate analysis of covariance (MANCOVA) revealed that the children with ADHD performed worse on correct responses had more commissions and omissions errors than the TD children, as well as slower target reaction times . The results showed significant differences between performance in the virtual environment and the traditional computerized one, with longer reaction times in virtual reality. The data analysis highlighted the negative influence of auditory distractors on attention performance in the case of the children with ADHD, but not for the TD children. Finally, the two measures did not differ on the cognitive absorption perceived by the children.

  11. Association of the CPT1B gene with skeletal muscle fat infiltration in Afro-Caribbean men.

    Science.gov (United States)

    Miljkovic, Iva; Yerges, Laura M; Li, Hu; Gordon, Christopher L; Goodpaster, Bret H; Kuller, Lewis H; Nestlerode, Cara S; Bunker, Clareann H; Patrick, Alan L; Wheeler, Victor W; Zmuda, Joseph M

    2009-07-01

    Skeletal muscle fat is greater in African ancestry individuals compared with whites, is associated with diabetes, and is a heritable polygenic trait. However, specific genetic factors contributing to skeletal muscle fat in humans remain to be defined. Muscle carnitine palmitoyltransferase-1B (CPT1B) is a key enzyme in the regulation of skeletal muscle mitochondrial beta-oxidation of long-chain fatty acids, and as such is a reasonable biological candidate gene for skeletal muscle fat accumulation. Therefore, we examined the association of three nonsynonymous coding variants in CPT1B (G531L, I66V, and S427C; a fourth, A320G, could not be genotyped) and quantitative computed tomography measured tibia skeletal muscle composition and BMI among 1,774 Afro-Caribbean men aged > or =40, participants of the population-based Tobago Health Study. For all variants, no significant differences were observed for BMI or total adipose tissue. Among individuals who were homozygous for the minor allele at G531L or I66V, intermuscular adipose tissue (IMAT) was 87% (P = 0.03) and 54% lower (P = 0.03), respectively. In contrast, subcutaneous adipose tissue (SAT) was 11% (P = 0.017) and 7% (P = 0.049) higher, respectively, than among individuals without these genotypes. These associations were independent of age, body size, and muscle area. Finally, no individuals with type 2 diabetes were found among those who were homozygous for the minor allele of either at G531L and I66V whereas 14-18% of men with the major alleles had type 2 diabetes (P = 0.03 and 0.007, respectively). Our results suggest a novel association between common nonsynonymous coding variants in CPT1B and ectopic skeletal muscle fat among middle-aged and older African ancestry men.

  12. Gupta--Bleuler's quantization of the anisotropic parity-even and CPT-even electrodynamics of standard model extension

    CERN Document Server

    Casana, R; Santos, F E P dos

    2014-01-01

    We have established the Gupta-Bleuler quantization of the photon belonging to the anisotropic parity-even sector of the CPT-even and Lorentz-violating nonbirefringent electrodynamics of the standard model extension. We first present a rule for the Maxwell electrodynamics to be successfully quantized via Gupta-Bleuler technique in the Lorentz gauge. Recognizing the failure of the Gupta-Bleuler method in the Lorentz gauge, $\\partial _{\\mu }A^{\\mu }=0$, for this massless LV theory, we argue that Gupta-Bleuler can be satisfactorily implemented by choosing a modified Lorentz condition, $\\partial _{\\mu }A^{\\mu }+\\kappa ^{\\mu \

  13. Classical solutions for the Lorentz-violating and CPT-even term of the Standard Model Extension

    CERN Document Server

    Casana, R; Santos, C E H

    2008-01-01

    In this work, we calculate the classical solutions for the electrodynamics stemming from the Lorentz-violating (LV) and CPT-even term of the Standard Model Extension. The solutions for point-like and extended charges are obtained from the wave equations by means of the Green method. A dipolar expansion is written for the field strengths. It is explicitly shown that charge and current generate first order effects for the magnetic and electric fields, respectively. Using the magnetic field generated by a macroscopic 1C charged sphere, we establish a stringent bound for the LV parameter:$\\kappa \\leq 10^{-16}.$

  14. Classical solutions for the Lorentz-violating and CPT-even term of the standard model extension

    Science.gov (United States)

    Casana, Rodolfo; Ferreira, Manoel M., Jr.; Santos, Carlos E. H.

    2008-11-01

    In this work, we calculate the classical solutions for the electrodynamics stemming from the Lorentz-violating (LV) and CPT-even term of the standard model extension. Static and stationary solutions for pointlike and extended charges are obtained from the wave equations by means of the Green method. A dipolar expansion is written for the field strengths. It is explicitly shown that charge and current generate LV first order effects for the magnetic and electric fields, respectively. Using the magnetic field generated by a macroscopic 1C charged sphere, we establish a stringent bound for the LV parameter: κ≤10-16.

  15. Radiative generation of the CPT-even gauge term of the SME from a dimension-five nonminimal coupling term

    Science.gov (United States)

    Casana, R.; Ferreira, M. M.; Maluf, R. V.; dos Santos, F. E. P.

    2013-11-01

    In this Letter we show for the first time that the usual CPT-even gauge term of the Standard Model Extension (SME), in its full structure, can be radiatively generated, in a gauge invariant level, in the context of a modified QED endowed with a dimension-five nonminimal coupling term recently proposed in the literature. As a consequence, the existing upper bounds on the coefficients of the tensor (KF) can be used to improve the bounds on the magnitude of the nonminimal coupling, λ(K), by the factors 105 or 1025. The nonminimal coupling also generates higher-order derivative contributions to the gauge field effective action quadratic terms.

  16. Cpt1a gene expression in peripheral blood mononuclear cells as an early biomarker of diet-related metabolic alterations

    Directory of Open Access Journals (Sweden)

    Rubén Díaz-Rúa

    2016-11-01

    Full Text Available Background: Research on biomarkers that provide early information about the development of future metabolic alterations is an emerging discipline. Gene expression analysis in peripheral blood mononuclear cells (PBMC is a promising tool to identify subjects at risk of developing diet-related diseases. Objective: We analysed PBMC expression of key energy homeostasis-related genes in a time-course analysis in order to find out early markers of metabolic alterations due to sustained intake of high-fat (HF and high-protein (HP diets. Design: We administered HF and HP diets (4 months to adult Wistar rats in isocaloric conditions to a control diet, mainly to avoid overweight associated with the intake of hyperlipidic diets and, thus, to be able to characterise markers of metabolically obese normal-weight (MONW syndrome. PBMC samples were collected at different time points of dietary treatment and expression of relevant energy homeostatic genes analysed by real-time reverse transcription-polymerase chain reaction. Serum parameters related with metabolic syndrome, as well as fat deposition in liver, were also analysed. Results: The most outstanding results were those obtained for the expression of the lipolytic gene carnitine palmitoyltransferase 1a (Cpt1a. Cpt1a expression in PBMC increased after only 1 month of exposure to both unbalanced diets, and this increased expression was maintained thereafter. Interestingly, in the case of the HF diet, Cpt1a expression was altered even in the absence of increased body weight but correlated with alterations such as higher insulin resistance, alteration of serum lipid profile and, particularly, increased fat deposition in liver, a feature characteristic of metabolic syndrome, which was even observed in animals fed with HP diet. Conclusions: We propose Cpt1a gene expression analysis in PBMC as an early biomarker of metabolic alterations associated with MONW phenotype due to the intake of isocaloric HF diets, as

  17. Federal and state management of inland wetlands: Are states ready to assume control?

    Science.gov (United States)

    Glubiak, Peter G.; Nowka, Richard H.; Mitsch, William J.

    1986-03-01

    As inland wetlands face increasing pressure for development, both the federal government and individual states have begun reevaluating their respective wetland regulatory schemes. This article focuses first on the effectiveness of the past, present, and proposed federal regulations, most notably the Section 404, Dredge and Fill Permit Program, in dealing with shrinking wetland resources. The article then addresses the status of state involvement in this largely federal area, as well as state preparedness to assume primacy should federal priorities change. Finally, the subject of comprehensive legislation for wetland protection is investigated, and the article concludes with some procedural suggestions for developing a model law.

  18. Phase tuning in Michelson-Morley experiments performed in vacuum, assuming length contraction

    CERN Document Server

    Levy, Joseph

    2010-01-01

    In agreement with Michelson-Morley experiments performed in vacuum, we show that, assuming the existence of a fundamental aether frame and of a length contraction affecting the material bodies in the direction of the Earth absolute velocity, the light signals, travelling along the arms of the interferometer arrive in phase whatever their orientation, a result which responds to an objection opposed to the non-entrained aether theory. This result constitutes a strong argument in support of length contraction and of the existence of a model of aether non-entrained by the motion of celestial bodies.

  19. Oxidation of hepatic carnitine palmitoyl transferase-I (CPT-I impairs fatty acid beta-oxidation in rats fed a methionine-choline deficient diet.

    Directory of Open Access Journals (Sweden)

    Gaetano Serviddio

    Full Text Available There is growing evidence that mitochondrial dysfunction, and more specifically fatty acid β-oxidation impairment, is involved in the pathophysiology of non-alcoholic steatohepatitis (NASH. The goal of the present study was to achieve more understanding on the modification/s of carnitinepalmitoyltransferase-I (CPT-I, the rate-limiting enzyme of the mitochondrial fatty acid β-oxidation, during steatohepatitis. A high fat/methionine-choline deficient (MCD diet, administered for 4 weeks, was used to induce NASH in rats.We demonstrated that CPT-I activity decreased, to the same extent, both in isolated liver mitochondria and in digitonin-permeabilized hepatocytes from MCD-diet fed rats.At the same time, the rate of total fatty acid oxidation to CO(2 and ketone bodies, measured in isolated hepatocytes, was significantly lowered in treated animals when compared to controls. Finally, an increase in CPT-I mRNA abundance and protein content, together with a high level of CPT-I protein oxidation was observed in treated rats. A posttranslational modification of rat CPT-I during steatohepatitis has been here discussed.

  20. Children's Everyday Learning by Assuming Responsibility for Others: Indigenous Practices as a Cultural Heritage Across Generations.

    Science.gov (United States)

    Fernández, David Lorente

    2015-01-01

    This chapter uses a comparative approach to examine the maintenance of Indigenous practices related with Learning by Observing and Pitching In in two generations--parent generation and current child generation--in a Central Mexican Nahua community. In spite of cultural changes and the increase of Western schooling experience, these practices persist, to different degrees, as a Nahua cultural heritage with close historical relations to the key value of cuidado (stewardship). The chapter explores how children learn the value of cuidado in a variety of everyday activities, which include assuming responsibility in many social situations, primarily in cultivating corn, raising and protecting domestic animals, health practices, and participating in family ceremonial life. The chapter focuses on three main points: (1) Cuidado (assuming responsibility for), in the Nahua socio-cultural context, refers to the concepts of protection and "raising" as well as fostering other beings, whether humans, plants, or animals, to reach their potential and fulfill their development. (2) Children learn cuidado by contributing to family endeavors: They develop attention and self-motivation; they are capable of responsible actions; and they are able to transform participation to achieve the status of a competent member of local society. (3) This collaborative participation allows children to continue the cultural tradition and to preserve a Nahua heritage at a deeper level in a community in which Nahuatl language and dress have disappeared, and people do not identify themselves as Indigenous.

  1. Aseismic Slips Preceding Ruptures Assumed for Anomalous Seismicities and Crustal Deformations

    Science.gov (United States)

    Ogata, Y.

    2007-12-01

    If aseismic slips occurs on a fault or its deeper extension, both seismicity and geodetic records around the source should be affected. Such anomalies are revealed to have occurred during the last several years leading up to the October 2004 Chuetsu Earthquake of M6.8, the March 2007 Noto Peninsula Earthquake of M6.9, and the July 2007 Chuetsu-Oki Earthquake of M6.8, which occurred successively in the near-field, central Japan. Seismic zones of negative and positive increments of the Coulomb failure stress, assuming such slips, show seismic quiescence and activation, respectively, relative to the predicted rate by the ETAS model. These are further supported by transient crustal movement around the source preceding the rupture. Namely, time series of the baseline distance records between a numbers of the permanent GPS stations deviated from the predicted trend, with the trend of different slope that is basically consistent with the horizontal displacements of the stations due to the assumed slips. References Ogata, Y. (2007) Seismicity and geodetic anomalies in a wide area preceding the Niigata-Ken-Chuetsu Earthquake of October 23, 2004, central Japan, J. Geophys. Res. 112, in press.

  2. Perceiving others' personalities: examining the dimensionality, assumed similarity to the self, and stability of perceiver effects.

    Science.gov (United States)

    Srivastava, Sanjay; Guglielmo, Steve; Beer, Jennifer S

    2010-03-01

    In interpersonal perception, "perceiver effects" are tendencies of perceivers to see other people in a particular way. Two studies of naturalistic interactions examined perceiver effects for personality traits: seeing a typical other as sympathetic or quarrelsome, responsible or careless, and so forth. Several basic questions were addressed. First, are perceiver effects organized as a global evaluative halo, or do perceptions of different traits vary in distinct ways? Second, does assumed similarity (as evidenced by self-perceiver correlations) reflect broad evaluative consistency or trait-specific content? Third, are perceiver effects a manifestation of stable beliefs about the generalized other, or do they form in specific contexts as group-specific stereotypes? Findings indicated that perceiver effects were better described by a differentiated, multidimensional structure with both trait-specific content and a higher order global evaluation factor. Assumed similarity was at least partially attributable to trait-specific content, not just to broad evaluative similarity between self and others. Perceiver effects were correlated with gender and attachment style, but in newly formed groups, they became more stable over time, suggesting that they grew dynamically as group stereotypes. Implications for the interpretation of perceiver effects and for research on personality assessment and psychopathology are discussed.

  3. 42 CFR 137.292 - How do Self-Governance Tribes assume environmental responsibilities for construction projects...

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false How do Self-Governance Tribes assume environmental...-Governance Tribes assume environmental responsibilities for construction projects under section 509 of the Act ? Self-Governance Tribes assume environmental responsibilities by: (a) Adopting a resolution...

  4. A CPT-based Cs vapor cell atomic clock with a short-term fractional frequency stability of 3 x 10-13 τ-1/2

    Science.gov (United States)

    Abdel Hafiz, Moustafa; Liu, Xiaochi; Guérandel, Stéphane; De Clercq, Emeric; Boudot, Rodolphe

    2016-06-01

    This article reports on the development and short-term fractional frequency stability of a continuous-regime (CW) Cs vapor cell atomic clock based on coherent population trapping (CPT). The push-pull optical pumping technique is used to increase the number of atoms that participate to the clock transition, yielding a typical CPT resonance contrast of 25% for a CPT linewidth of about 450 Hz. The clock short-term fractional frequency stability is measured to be 3 x 10-13 τ-1/2 up to 100 seconds averaging time, in correct agreement with the signal-to-noise ratio limit. The mid-term frequency stability results are currently mainly limited by laser power effects. The detection of high-contrast narrow Raman-Ramsey fringes is demonstrated with this setup by making the atoms interact with a light pulse sequence.

  5. An assumed pdf approach for the calculation of supersonic mixing layers

    Science.gov (United States)

    Baurle, R. A.; Drummond, J. P.; Hassan, H. A.

    1992-01-01

    In an effort to predict the effect that turbulent mixing has on the extent of combustion, a one-equation turbulence model is added to an existing Navier-Stokes solver with finite-rate chemistry. To average the chemical-source terms appearing in the species-continuity equations, an assumed pdf approach is also used. This code was used to analyze the mixing and combustion caused by the mixing layer formed by supersonic coaxial H2-air streams. The chemistry model employed allows for the formation of H2O2 and HO2. Comparisons are made with recent measurements using laser Raman diagnostics. Comparisons include temperature and its rms, and concentrations of H2, O2, N2, H2O, and OH. In general, good agreement with experiment was noted.

  6. Analysis of an object assumed to contain “Red Mercury”

    Science.gov (United States)

    Obhođaš, Jasmina; Sudac, Davorin; Blagus, Saša; Valković, Vladivoj

    2007-08-01

    After having been informed about an attempt of illicit trafficking, the Organized Crime Division of the Zagreb Police Authority confiscated in November 2003 a hand size metal cylinder suspected to contain "Red Mercury" (RM). The sample assumed to contain RM was analyzed with two nondestructive analytical methods in order to obtain information about the nature of the investigated object, namely, activation analysis with 14.1 MeV neutrons and EDXRF analysis. The activation analysis with 14.1 MeV neutrons showed that the container and its contents were characterized by the following chemical elements: Hg, Fe, Cr and Ni. By using EDXRF analysis, it was shown that the elements Fe, Cr and Ni were constituents of the capsule. Therefore, it was concluded that these three elements were present in the capsule only, while the content of the unknown material was Hg. Antimony as a hypothetical component of red mercury was not detected.

  7. Estimating option values of solar radiation management assuming that climate sensitivity is uncertain.

    Science.gov (United States)

    Arino, Yosuke; Akimoto, Keigo; Sano, Fuminori; Homma, Takashi; Oda, Junichiro; Tomoda, Toshimasa

    2016-05-24

    Although solar radiation management (SRM) might play a role as an emergency geoengineering measure, its potential risks remain uncertain, and hence there are ethical and governance issues in the face of SRM's actual deployment. By using an integrated assessment model, we first present one possible methodology for evaluating the value arising from retaining an SRM option given the uncertainty of climate sensitivity, and also examine sensitivities of the option value to SRM's side effects (damages). Reflecting the governance challenges on immediate SRM deployment, we assume scenarios in which SRM could only be deployed with a limited degree of cooling (0.5 °C) only after 2050, when climate sensitivity uncertainty is assumed to be resolved and only when the sensitivity is found to be high (T2x = 4 °C). We conduct a cost-effectiveness analysis with constraining temperature rise as the objective. The SRM option value is originated from its rapid cooling capability that would alleviate the mitigation requirement under climate sensitivity uncertainty and thereby reduce mitigation costs. According to our estimates, the option value during 1990-2049 for a +2.4 °C target (the lowest temperature target level for which there were feasible solutions in this model study) relative to preindustrial levels were in the range between $2.5 and $5.9 trillion, taking into account the maximum level of side effects shown in the existing literature. The result indicates that lower limits of the option values for temperature targets below +2.4 °C would be greater than $2.5 trillion.

  8. [cAMP analogue 8-CPT-cAMP inducing differentiation in the M2b subtype of acute myeloid leukemia cell line Kasumi-1].

    Science.gov (United States)

    Zhu, Qi; Hu, Jun-Pei; Jia, Pei-Min; Wang, Zhen-Yi; Tong, Jian-Hua

    2008-02-01

    This study was aimed to investigate the possible effects of cyclic adenosine monophosphate (cAMP) analogue 8-(4-chlorophenylthio) adenosine 3', 5'-cyclic monophosphate (8-CPT-cAMP) on the M(2b) subtype of acute myeloid leukemia (AML-M(2b)) cells. AML-M(2b) is characterized by the non-random chromosome translocation t (8; 21) (q22; q22), through which AML1 (acute myeloid leukemia 1) gene on chromosome 21 is fused with ETO (eight twenty-one) gene on chromosome 8, coding correspondent AML1-ETO fusion protein, which plays a crucial role in the leukemogenesis of AML-M(2b). The AML-M(2b) cell line Kasumi-1 cells were used as an in vitro model. The influences of 8-CPT-cAMP on the proliferation and differentiation of Kasumi-1 cells were evaluated according to cellular morphology, changes in cell surface antigen and cell cycle, as well as nitroblue-tetrazolium (NBT) assay. Meanwhile, semi-quantity RT-PCR and Western blot assay were used to detect the degradation of AML1-ETO fusion protein in Kasumi-1 cells before and after the treatment. The results showed that 8-CPT-cAMP (200 micromol/L) could significantly inhibit cell growth and induce differentiation of Kasumi-1 cells. However, it must be pointed out that 8-CPT-cAMP-induced differentiation in Kasumi-1 is not a typical terminal differentiation. Furthermore, 8-CPT-cAMP exerted little influence on the expression of AML1-ETO fusion gene and its product in Kasumi-1 cells. In conclusion, the 8-CPT-cAMP induced differentiation in Kasumi-1 cells. This results may provide experimental and theoretical basis for the breakthrough of differentiation-induced therapy extended to another leukemia.

  9. Tsunami Waveform Inversion without Assuming Fault Models- Application to Recent Three Earthquakes around Japan

    Science.gov (United States)

    Namegaya, Y.; Ueno, T.; Satake, K.; Tanioka, Y.

    2010-12-01

    Tsunami waveform inversion is often used to study the source of tsunamigenic earthquakes. In this method, subsurface fault planes are divided into small subfaults, and the slip distribution, then seafloor deformation are estimated. However, it is sometimes difficult to judge the actual fault plane for offshore earthquake such as those along the eastern margin of Japan Sea. We developed an inversion method to estimate vertical seafloor deformation directly from observed tsunami waveforms. The tsunami source area is divided into many nodes, and the vertical seafloor deformation is calculated around each node by using the B-spline functions. The tsunami waveforms are calculated from each node, and used as the Green’s functions for inversion. To stabilize inversion or avoid overestimation of data errors, we introduce smoothing equations like Laplace’s equations. The optimum smoothing strength is estimated from the Akaike’s Bayesian information criterion (ABIC) Method. Advantage of this method is to estimate the vertical seafloor deformation can be estimated without assuming a fault plane. We applied the method to three recent earthquakes around Japan: the 2007 Chuetsu-oki, 2007 Noto Hanto, and 2003 Tokachi-oki earthquakes. The Chuetsu-oki earthquake (M6.8) occurred off the Japan Sea coast of central Japan on 16 July 2007. For this earthquake, complicated aftershock distribution makes it difficult to judge which of the southeast dipping fault or the northwest dipping fault was the actual fault plane. The tsunami inversion result indicates that the uplifted area extends about 10 km from the coastline, and there are two peaks of uplift: about 40 cm in the south and about 20 cm in the north. TheNoto Hanto earthquake (M6.9) occurred off Noto peninsula, also along the Japan Sea coast of central Japan, on 25 March 2007. The inversion result indicates that the uplifted area extends about 10 km off the coast, and the largest uplift amount is more than 40 cm. Location of

  10. THM Coupled Modeling in Near Field of an Assumed HLW Deep Geological Disposal Repository

    Institute of Scientific and Technical Information of China (English)

    Shen Zhenyao; Li Guoding; Li Shushen

    2004-01-01

    One of the most suitable ways under study for the disposal of high-level radioactive waste (HLW) is isolation in deep geological repositories. It is very important to research the thermo-hydro-mechanical (THM) coupled processes associated with an HLW disposal repository. Non-linear coupled equations, which are used to describe the THM coupled process and are suited to saturated-unsaturated porous media, are presented in this paper. A numerical method to solve these equations is put forward, and a finite element code is developed. This code is suited to the plane strain or axis-symmetry problem. Then this code is used to simulate the THM coupled process in the near field of an ideal disposal repository. The temperature vs. time, hydraulic head vs. time and stress vs. time results show that, in this assumed condition, the impact of temperature is very long (over 10 000 a) and the impact of the water head is short (about 90 d). Since the stress is induced by temperature and hydraulic head in this condition, the impact time of stress is the same as that of temperature. The results show that THM coupled processes are very important in the safety analysis of an HLW deep geological disposal repository.

  11. Wetware, Hardware, or Software Incapacitation: Observational Methods to Determine When Autonomy Should Assume Control

    Science.gov (United States)

    Trujillo, Anna C.; Gregory, Irene M.

    2014-01-01

    Control-theoretic modeling of human operator's dynamic behavior in manual control tasks has a long, rich history. There has been significant work on techniques used to identify the pilot model of a given structure. This research attempts to go beyond pilot identification based on experimental data to develop a predictor of pilot behavior. Two methods for pre-dicting pilot stick input during changing aircraft dynamics and deducing changes in pilot behavior are presented This approach may also have the capability to detect a change in a subject due to workload, engagement, etc., or the effects of changes in vehicle dynamics on the pilot. With this ability to detect changes in piloting behavior, the possibility now exists to mediate human adverse behaviors, hardware failures, and software anomalies with autono-my that may ameliorate these undesirable effects. However, appropriate timing of when au-tonomy should assume control is dependent on criticality of actions to safety, sensitivity of methods to accurately detect these adverse changes, and effects of changes in levels of auto-mation of the system as a whole.

  12. Radial diffusion in Saturn's radiation belts - A modeling analysis assuming satellite and ring E absorption

    Science.gov (United States)

    Hood, L. L.

    1983-01-01

    A modeling analysis is carried out of six experimental phase space density profiles for nearly equatorially mirroring protons using methods based on the approach of Thomsen et al. (1977). The form of the time-averaged radial diffusion coefficient D(L) that gives an optimal fit to the experimental profiles is determined under the assumption that simple satellite plus Ring E absorption of inwardly diffusing particles and steady-state radial diffusion are the dominant physical processes affecting the proton data in the L range that is modeled. An extension of the single-satellite model employed by Thomsen et al. to a model that includes multisatellite and ring absorption is described, and the procedures adopted for estimating characteristic satellite and ring absorption times are defined. The results obtained in applying three representative solid-body absorption models to evaluate D(L) in the range where L is between 4 and 16 are reported, and a study is made of the sensitivity of the preferred amplitude and L dependence for D(L) to the assumed model parameters. The inferred form of D(L) is then compared with that which would be predicted if various proposed physical mechanisms for driving magnetospheric radial diffusion are operative at Saturn.

  13. Artificially introduced aneuploid chromosomes assume a conserved position in colon cancer cells.

    Directory of Open Access Journals (Sweden)

    Kundan Sengupta

    Full Text Available BACKGROUND: Chromosomal aneuploidy is a defining feature of carcinomas. For instance, in colon cancer, an additional copy of Chromosome 7 is not only observed in early pre-malignant polyps, but is faithfully maintained throughout progression to metastasis. These copy number changes show a positive correlation with average transcript levels of resident genes. An independent line of research has also established that specific chromosomes occupy a well conserved 3D position within the interphase nucleus. METHODOLOGY/PRINCIPAL FINDINGS: We investigated whether cancer-specific aneuploid chromosomes assume a 3D-position similar to that of its endogenous homologues, which would suggest a possible correlation with transcriptional activity. Using 3D-FISH and confocal laser scanning microscopy, we show that Chromosomes 7, 18, or 19 introduced via microcell-mediated chromosome transfer into the parental diploid colon cancer cell line DLD-1 maintain their conserved position in the interphase nucleus. CONCLUSIONS: Our data is therefore consistent with the model that each chromosome has an associated zip code (possibly gene density that determines its nuclear localization. Whether the nuclear localization determines or is determined by the transcriptional activity of resident genes has yet to be ascertained.

  14. Automated Assume-Guarantee Reasoning for Omega-Regular Systems and Specifications

    Science.gov (United States)

    Chaki, Sagar; Gurfinkel, Arie

    2010-01-01

    We develop a learning-based automated Assume-Guarantee (AG) reasoning framework for verifying omega-regular properties of concurrent systems. We study the applicability of non-circular (AGNC) and circular (AG-C) AG proof rules in the context of systems with infinite behaviors. In particular, we show that AG-NC is incomplete when assumptions are restricted to strictly infinite behaviors, while AG-C remains complete. We present a general formalization, called LAG, of the learning based automated AG paradigm. We show how existing approaches for automated AG reasoning are special instances of LAG.We develop two learning algorithms for a class of systems, called infinite regular systems, that combine finite and infinite behaviors. We show that for infinity-regular systems, both AG-NC and AG-C are sound and complete. Finally, we show how to instantiate LAG to do automated AG reasoning for infinite regular, and omega-regular, systems using both AG-NC and AG-C as proof rules

  15. Cardiovascular Responses during Head-Down Crooked Kneeling Position Assumed in Muslim Prayers

    Directory of Open Access Journals (Sweden)

    Adamu Ahmad Rufa’i

    2013-06-01

    Full Text Available Background: Movement dysfunction may be expressed in terms of symptoms experienced in non-physiological postures, and head-down crooked kneeling (HDCK is a posture frequently assumed by Muslims during prayer activities. The purpose of this study was to investigate the cardiovascular responses in the HDCK posture. Methods: Seventy healthy volunteers, comprising 35 males and 35 females, participated in the study. Cardiovascular parameters of blood pressure and pulse rate of the participants were measured in rested sitting position and then at one and three minutes into the HDCK posture. Two-way ANOVA was used to determine the differences between cardiovascular responses at rest and in the HDCK posture, and the Student t test was utilized to determine gender difference in cardiovascular responses at rest and at one and three minutes into the HDCK posture. Results: The study showed a significant decrease in systolic and diastolic blood pressures at one minute into the HDCK posture and an increase in pulse rate at one and three minutes into the HDCK posture, as compared to the resting values. Rate pressure product also rose at one minute into the HDCK posture, whereas pulse pressure increased at one and three minutes into the HDCK posture, as compared with the resting values. However, no significant change was observed in the mean arterial pressure values. Conclusion: The findings from this study suggest that no adverse cardiovascular event can be expected to occur for the normal duration of this posture during Muslim prayer activities.

  16. Cardiovascular Responses during Head-Down Crooked Kneeling Position Assumed in Muslim Prayers

    Science.gov (United States)

    Ahmad Rufa’i, Adamu; Hamu Aliyu, Hadeezah; Yunoos Oyeyemi, Adetoyeje; Lukman Oyeyemi, Adewale

    2013-01-01

    Background: Movement dysfunction may be expressed in terms of symptoms experienced in non-physiological postures, and head-down crooked kneeling (HDCK) is a posture frequently assumed by Muslims during prayer activities. The purpose of this study was to investigate the cardiovascular responses in the HDCK posture. Methods: Seventy healthy volunteers, comprising 35 males and 35 females, participated in the study. Cardiovascular parameters of blood pressure and pulse rate of the participants were measured in rested sitting position and then at one and three minutes into the HDCK posture. Two-way ANOVA was used to determine the differences between cardiovascular responses at rest and in the HDCK posture, and the Student t test was utilized to determine gender difference in cardiovascular responses at rest and at one and three minutes into the HDCK posture. Results: The study showed a significant decrease in systolic and diastolic blood pressures at one minute into the HDCK posture and an increase in pulse rate at one and three minutes into the HDCK posture, as compared to the resting values. Rate pressure product also rose at one minute into the HDCK posture, whereas pulse pressure increased at one and three minutes into the HDCK posture, as compared with the resting values. However, no significant change was observed in the mean arterial pressure values. Conclusion: The findings from this study suggest that no adverse cardiovascular event can be expected to occur for the normal duration of this posture during Muslim prayer activities. PMID:24031108

  17. The Role of Psychometrics in Individual Differences Research in Cognition: A Case Study of the AX-CPT

    Directory of Open Access Journals (Sweden)

    Shelly R. Cooper

    2017-09-01

    Full Text Available Investigating individual differences in cognition requires addressing questions not often thought about in standard experimental designs, especially regarding the psychometric properties of the task. Using the AX-CPT cognitive control task as a case study example, we address four concerns that one may encounter when researching the topic of individual differences in cognition. First, we demonstrate the importance of variability in task scores, which in turn directly impacts reliability, particularly when comparing correlations in different populations. Second, we demonstrate the importance of variability and reliability for evaluating potential failures to replicate predicted correlations, even within the same population. Third, we demonstrate how researchers can turn to evaluating psychometric properties as a way of evaluating the feasibility of utilizing the task in new settings (e.g., online administration. Lastly, we show how the examination of psychometric properties can help researchers make informed decisions when designing a study, such as determining the appropriate number of trials for a task.

  18. The Role of Psychometrics in Individual Differences Research in Cognition: A Case Study of the AX-CPT

    Science.gov (United States)

    Cooper, Shelly R.; Gonthier, Corentin; Barch, Deanna M.; Braver, Todd S.

    2017-01-01

    Investigating individual differences in cognition requires addressing questions not often thought about in standard experimental designs, especially regarding the psychometric properties of the task. Using the AX-CPT cognitive control task as a case study example, we address four concerns that one may encounter when researching the topic of individual differences in cognition. First, we demonstrate the importance of variability in task scores, which in turn directly impacts reliability, particularly when comparing correlations in different populations. Second, we demonstrate the importance of variability and reliability for evaluating potential failures to replicate predicted correlations, even within the same population. Third, we demonstrate how researchers can turn to evaluating psychometric properties as a way of evaluating the feasibility of utilizing the task in new settings (e.g., online administration). Lastly, we show how the examination of psychometric properties can help researchers make informed decisions when designing a study, such as determining the appropriate number of trials for a task. PMID:28928690

  19. Gupta-Bleuler's quantization of a parity-odd CPT-even electrodynamics of the standard model extension

    CERN Document Server

    Casana, R; Santos, F E P dos

    2016-01-01

    {Following a successfully quantization scheme previously }{{% developed {\\ in Ref. \\cite{GUPTAEVEN} for a}} parity-even {gauge sector} {of the SME, we}} have established the Gupta-Bleuler {% quantization {of a} {\\ parity-odd} and CPT-even }electrodynamics of {the }standard model extension (SME) {without recoursing to a small photon mass regulator}. {Keeping the photons massless,} {% {we have adopted the gauge fixing condition:}} $G(A_{\\mu })=(\\partial _{0}+\\kappa^{0j}\\partial _{j}) (A_{0}+\\kappa ^{0k}A_{k})+\\partial _{i}A^{i}$% . The{\\ four} polarization vectors of the gauge field are {% exactly} determined by solving an eigenvalue problem,{\\ exhibiting birefringent second order contributions in the Lorentz-violating parameters}% . They allow to express the Hamiltonian in terms of annihilation and creation operators whose positivity is guaranteed by imposing a weak Gupta-Bleuler constraint, defining the physical states. Consequently, we compute the field commutation relation which has been expressed in terms ...

  20. Non-orthogonality and $\\kappa$-dependence eccentricity of polarized electromagnetic waves in CPT-even Lorentz violation

    CERN Document Server

    Prudencio, Thiago

    2016-01-01

    We discuss the modified Maxwell action of a $K_{F}$-type Lorentz symmetry breaking theory and present a solution of Maxwell equations derived in the cases of linear and elliptically polarized electromagnetic waves in the vacuum of CPT-even Lorentz violation. We show in this case the Lorentz violation has the effect of changing the amplitude of one component of the magnetic field, while leaving the electric field unchanged, leading to non-orthogonal propagation of eletromagnetic fields and dependence of the eccentricity on $\\kappa$-term. Further, we exhibit numerically the consequences of this effect in the cases of linear and elliptical polarization, in particular, the regimes of non-orthogonality of the electromagnetic wave fields and the eccentricity of the elliptical polarization of the magnetic field with dependence on the $\\kappa$-term.

  1. Radiative generation of the CPT-even gauge term of the SME from a dimension-five nonminimal coupling term

    Energy Technology Data Exchange (ETDEWEB)

    Casana, R., E-mail: rodolfo.casana@gmail.com [Universidade Federal do Maranhão (UFMA), Departamento de Física, Campus Universitário do Bacanga, São Luís, MA, 65085-580 (Brazil); Ferreira, M.M., E-mail: manojr07@ibest.com.br [Universidade Federal do Maranhão (UFMA), Departamento de Física, Campus Universitário do Bacanga, São Luís, MA, 65085-580 (Brazil); Maluf, R.V., E-mail: robertovinhaes@fisica.ufc.br [Universidade Federal do Ceará (UFC), Departamento de Física, Campus do Pici, Fortaleza, CE, C.P. 6030, 60455-760 (Brazil); Santos, F.E.P. dos, E-mail: fredegol@ibest.com.br [Universidade Federal do Maranhão (UFMA), Departamento de Física, Campus Universitário do Bacanga, São Luís, MA, 65085-580 (Brazil)

    2013-11-04

    In this Letter we show for the first time that the usual CPT-even gauge term of the Standard Model Extension (SME), in its full structure, can be radiatively generated, in a gauge invariant level, in the context of a modified QED endowed with a dimension-five nonminimal coupling term recently proposed in the literature. As a consequence, the existing upper bounds on the coefficients of the tensor (K{sub F}) can be used to improve the bounds on the magnitude of the nonminimal coupling, λ(K{sub σF}), by the factors 10{sup 5} or 10{sup 25}. The nonminimal coupling also generates higher-order derivative contributions to the gauge field effective action quadratic terms.

  2. Radiative generation of the CPT-even gauge term of the SME from a dimension-five nonminimal coupling term

    CERN Document Server

    Casana, R; Maluf, R V; Santos, F E P dos

    2013-01-01

    In this letter we show for the first time that the usual CPT-even gauge term of the standard model extension (SME) can be radiatively generated, \\textbf{}in a gauge invariant level, in the context of a modified QED endowed with a dimension-five nonminimal coupling term recently proposed in the literature. As a consequence, the existing upper bounds on the coefficients of the tensor $(K_{F}) $ can be used improve the bounds on the magnitude of the nonminimal coupling, $\\lambda(K_{F}),$ by the factors $10^{5}$ or $10^{25}.$ The nonminimal coupling also generates higher-order derivative contributions to the gauge field effective action quadratic terms.

  3. Limit on Lorentz-Invariance- and CPT-Violating Neutron Spin Interactions Using a $^3$He-$^{129}$Xe Comagnetometer

    CERN Document Server

    Allmendinger, Fabian; Heil, Werner; Karpuk, Sergej; Sobolev, Yuri

    2016-01-01

    We performed a search for a Lorentz-invariance- and CPT-violating coupling of the $^3$He and $^{129}$Xe nuclear spins to posited background fields. Our experimental approach is to measure the free precession of nuclear spin polarized $^3$He and $^{129}$Xe atoms using SQUID detectors. As the laboratory reference frame rotates with respect to distant stars, we look for a sidereal modulation of the Larmor frequencies of the co-located spin samples. As a result we obtain an upper limit on the equatorial component of the background field $\\tilde{b}^n_{\\bot}< 8.4 \\cdot 10^{-34}$ GeV (68\\% C.L.). Furthermore, this technique was modified to search for an electric dipole moment (EDM) of $^{129}$Xe.

  4. Engineering evaluation of alternatives: Managing the assumed leak from single-shell Tank 241-T-101

    Energy Technology Data Exchange (ETDEWEB)

    Brevick, C.H. [ICF Kaiser Hanford Co., Richland, WA (United States); Jenkins, C. [Westinghouse Hanford Co., Richland, WA (United States)

    1996-02-01

    At mid-year 1992, the liquid level gage for Tank 241-T-101 indicated that 6,000 to 9,000 gal had leaked. Because of the liquid level anomaly, Tank 241-T-101 was declared an assumed leaker on October 4, 1992. SSTs liquid level gages have been historically unreliable. False readings can occur because of instrument failures, floating salt cake, and salt encrustation. Gages frequently self-correct and tanks show no indication of leak. Tank levels cannot be visually inspected and verified because of high radiation fields. The gage in Tank 241-T-101 has largely corrected itself since the mid-year 1992 reading. Therefore, doubt exists that a leak has occurred, or that the magnitude of the leak poses any immediate environmental threat. While reluctance exists to use valuable DST space unnecessarily, there is a large safety and economic incentive to prevent or mitigate release of tank liquid waste into the surrounding environment. During the assessment of the significance of the Tank 241-T-101 liquid level gage readings, Washington State Department of Ecology determined that Westinghouse Hanford Company was not in compliance with regulatory requirements, and directed transfer of the Tank 241-T-101 liquid contents into a DST. Meanwhile, DOE directed WHC to examine reasonable alternatives/options for safe interim management of Tank 241-T-101 wastes before taking action. The five alternatives that could be used to manage waste from a leaking SST are: (1) No-Action, (2) In-Tank Stabilization, (3) External Tank Stabilization, (4) Liquid Retrieval, and (5) Total Retrieval. The findings of these examinations are reported in this study.

  5. The Effects on Tsunami Hazard Assessment in Chile of Assuming Earthquake Scenarios with Spatially Uniform Slip

    Science.gov (United States)

    Carvajal, Matías; Gubler, Alejandra

    2016-12-01

    We investigated the effect that along-dip slip distribution has on the near-shore tsunami amplitudes and on coastal land-level changes in the region of central Chile (29°-37°S). Here and all along the Chilean megathrust, the seismogenic zone extends beneath dry land, and thus, tsunami generation and propagation is limited to its seaward portion, where the sensitivity of the initial tsunami waveform to dislocation model inputs, such as slip distribution, is greater. We considered four distributions of earthquake slip in the dip direction, including a spatially uniform slip source and three others with typical bell-shaped slip patterns that differ in the depth range of slip concentration. We found that a uniform slip scenario predicts much lower tsunami amplitudes and generally less coastal subsidence than scenarios that assume bell-shaped distributions of slip. Although the finding that uniform slip scenarios underestimate tsunami amplitudes is not new, it has been largely ignored for tsunami hazard assessment in Chile. Our simulations results also suggest that uniform slip scenarios tend to predict later arrival times of the leading wave than bell-shaped sources. The time occurrence of the largest wave at a specific site is also dependent on how the slip is distributed in the dip direction; however, other factors, such as local bathymetric configurations and standing edge waves, are also expected to play a role. Arrival time differences are especially critical in Chile, where tsunamis arrive earlier than elsewhere. We believe that the results of this study will be useful to both public and private organizations for mapping tsunami hazard in coastal areas along the Chilean coast, and, therefore, help reduce the risk of loss and damage caused by future tsunamis.

  6. Secretome profile analysis of hypervirulent Mycobacterium tuberculosis CPT31 reveals increased production of EsxB and proteins involved in adaptation to intracellular lifestyle.

    Science.gov (United States)

    Vargas-Romero, Fernado; Guitierrez-Najera, Nora; Mendoza-Hernández, Guillermo; Ortega-Bernal, Daniel; Hernández-Pando, Rogelio; Castañón-Arreola, Mauricio

    2016-03-01

    Epidemiological information and animal models have shown various Mycobacterium tuberculosis phenotypes ranging from hyper- to hypovirulent forms. Recent genomic and proteomic studies suggest that the outcome of infection depends on the M. tuberculosis fitness, which is a direct consequence of its phenotype. However, little is known about the molecular and cellular mechanisms used by mycobacteria to survive, replicate and persist during infection. The aim of this study was to perform a comprehensive proteomic analysis of culture filtrate from hypo- (CPT23) and hypervirulent (CPT31) M. tuberculosis isolates. Using two-dimensional electrophoresis we observed that 70 proteins were unique, or more abundant in culture filtrate of CPT31, and 15 of these were identified by mass spectrometry. Our analysis of protein expression showed that most of the proteins identified are involved in lipid metabolism (FadA3, FbpB and EchA3), detoxification and adaptation (GroEL2, SodB and HspX) and cell wall processes (LprA, Tig and EsxB). These results suggest that overrepresented proteins in M. tuberculosis CPT31 secretome could facilitate mycobacterial infection and persistence.

  7. Off-target effect of the Epac agonist 8-pCPT-2'-O-Me-cAMP on P2Y12 receptors in blood platelets.

    Science.gov (United States)

    Herfindal, Lars; Nygaard, Gyrid; Kopperud, Reidun; Krakstad, Camilla; Døskeland, Stein Ove; Selheim, Frode

    2013-08-09

    The primary target of the cAMP analogue 8-pCPT-2'-O-Me-cAMP is exchange protein directly activated by cAMP (Epac). Here we tested potential off-target effects of the Epac activator on blood platelet activation signalling. We found that the Epac analogue 8-pCPT-2'-O-Me-cAMP inhibits agonist-induced-GPCR-stimulated, but not collagen-stimulated, P-selectin surface expression on Epac1 deficient platelets. In human platelets, 8-pCPT-2'-O-Me-cAMP inhibited P-selectin expression elicited by the PKC activator PMA. This effect was abolished in the presence of the extracellular ADP scavenger system CP/CPK. In silico modelling of 8-pCPT-2'O-Me-cAMP binding into the purinergic platelet receptor P2Y12 revealed that the analogue docks similar to the P2Y12 antagonist 2MeSAMP. The 8-pCPT-2'-O-Me-cAMP analogue per se, did not provoke Rap 1 (Rap 1-GTP) activation or phosphorylation on the vasodilator-stimulated phosphoprotein (VASP) at Ser-157. In addition, the protein kinase A (PKA) antagonists Rp-cAMPS and Rp-8-Br-cAMPS failed to block the inhibitory effect of 8-pCPT-2'-O-Me-cAMP on thrombin- and TRAP-induced Rap 1 activation, thus suggesting that PKA is not involved. We conclude that the 8-pCPT-2'-O-Me-cAMP analogue is able to inhibit agonist-induced-GPCR-stimulated P-selectin independent from Epac1; the off-target effect of the analogue appears to be mediated by antagonistic P2Y12 receptor binding. This has implications when using cAMP analogues on specialised system involving such receptors. We found, however that the Epac agonist 8-Br-2'-O-Me-cAMP did not affect platelet activation at similar concentrations.

  8. Internal Structure and Mineralogy of Differentiated Asteroids Assuming Chondritic Bulk Composition: The Case of Vesta

    Science.gov (United States)

    Toplis, M. J.; Mizzon, H.; Forni, O.; Monnereau, M.; Prettyman, T. H.; McSween, H. Y.; McCoy, T. J.; Mittlefehldt, D. W.; DeSanctis, M. C.; Raymond, C. A.; Russell, C. T.

    2012-01-01

    Bulk composition (including oxygen content) is a primary control on the internal structure and mineralogy of differentiated asteroids. For example, oxidation state will affect core size, as well as Mg# and pyroxene content of the silicate mantle. The Howardite-Eucrite-Diogenite class of meteorites (HED) provide an interesting test-case of this idea, in particular in light of results of the Dawn mission which provide information on the size, density and differentiation state of Vesta, the parent body of the HED's. In this work we explore plausible bulk compositions of Vesta and use mass-balance and geochemical modelling to predict possible internal structures and crust/mantle compositions and mineralogies. Models are constrained to be consistent with known HED samples, but the approach has the potential to extend predictions to thermodynamically plausible rock types that are not necessarily present in the HED collection. Nine chondritic bulk compositions are considered (CI, CV, CO, CM, H, L, LL, EH, EL). For each, relative proportions and densities of the core, mantle, and crust are quantified. Considering that the basaltic crust has the composition of the primitive eucrite Juvinas and assuming that this crust is in thermodynamic equilibrium with the residual mantle, it is possible to calculate how much iron is in metallic form (in the core) and how much in oxidized form (in the mantle and crust) for a given bulk composition. Of the nine bulk compositions tested, solutions corresponding to CI and LL groups predicted a negative metal fraction and were not considered further. Solutions for enstatite chondrites imply significant oxidation relative to the starting materials and these solutions too are considered unlikely. For the remaining bulk compositions, the relative proportion of crust to bulk silicate is typically in the range 15 to 20% corresponding to crustal thicknesses of 15 to 20 km for a porosity-free Vesta-sized body. The mantle is predicted to be largely

  9. Identification of a novel malonyl-CoA IC(50) for CPT-I: implications for predicting in vivo fatty acid oxidation rates.

    Science.gov (United States)

    Smith, Brennan K; Perry, Christopher G R; Koves, Timothy R; Wright, David C; Smith, Jeffrey C; Neufer, P Darrell; Muoio, Deborah M; Holloway, Graham P

    2012-11-15

    Published values regarding the sensitivity (IC(50)) of CPT-I (carnitine palmitoyltransferase I) to M-CoA (malonyl-CoA) inhibition in isolated mitochondria are inconsistent with predicted in vivo rates of fatty acid oxidation. Therefore we have re-examined M-CoA inhibition kinetics under various P-CoA (palmitoyl-CoA) concentrations in both isolated mitochondria and PMFs (permeabilized muscle fibres). PMFs have an 18-fold higher IC(50) (0.61 compared with 0.034 μM) in the presence of 25 μM P-CoA and a 13-fold higher IC(50) (6.3 compared with 0.49 μM) in the presence of 150 μM P-CoA compared with isolated mitochondria. M-CoA inhibition kinetics determined in PMFs predicts that CPT-I activity is inhibited by 33% in resting muscle compared with >95% in isolated mitochondria. Additionally, the ability of M-CoA to inhibit CPT-I appears to be dependent on P-CoA concentration, as the relative inhibitory capacity of M-CoA is decreased with increasing P-CoA concentrations. Altogether, the use of PMFs appears to provide an M-CoA IC(50) that better reflects the predicted in vivo rates of fatty acid oxidation. These findings also demonstrate that the ratio of [P-CoA]/[M-CoA] is critical for regulating CPT-I activity and may partially rectify the in vivo disconnect between M-CoA content and CPT-I flux within the context of exercise and Type 2 diabetes.

  10. Identification of a novel malonyl-CoA IC50 for CPT-1: implications for predicting in vivo fatty acid oxidation rates

    Science.gov (United States)

    Smith, Brennan K.; Perry, Christopher G.R.; Koves, Timothy R.; Wright, David C.; Smith, Jeffrey C.; Neufer, P. Darrell; Muoio, Deborah M.; Holloway, Graham P.

    2013-01-01

    Synopsis Published values regarding the sensitivity (IC50) of carnitine palmitoyl transferase I (CPT-I) to malonyl-CoA (M-CoA) inhibition in isolated mitochondria are inconsistent with predicted in vivo rates of fatty acid oxidation. Therefore, we have re-examined M-CoA inhibition kinetics under varying palmitoyl-CoA (P-CoA) concentrations in both isolated mitochondria and permeabilized muscle fibres (PMF). PMF have an 18-fold higher IC50 (0.61 vs 0.034 μM) in the presence of 25 μM P-CoA and a 13-fold higher IC50 (6.3 vs 0.49 μM) in the presence of 150 μM P-CoA compared to isolated mitochondria. M-CoA inhibition kinetics determined in PMF predicts that CPT-I activity is inhibited by 33% in resting muscle compared to >95% in isolated mitochondria. Additionally, the ability of M-CoA to inhibit CPT-I appears to be dependent on P-CoA concentration, as the relative inhibitory capacity of M-CoA is decreased with increasing P-CoA concentrations. Altogether, the use of PMF appears to provide a M-CoA IC50 that better reflects the predicted in vivo rates of fatty acid oxidation. These findings also demonstrate the ratio of [P-CoA]/[M-CoA] is critical for regulating CPT-I activity and may partially rectify the in vivo disconnect between M-CoA content and CPT-I flux within the context of exercise and type II diabetes. PMID:22928974

  11. 25 CFR 224.64 - How may a tribe assume management of development of different types of energy resources?

    Science.gov (United States)

    2010-04-01

    ... Requirements § 224.64 How may a tribe assume management of development of different types of energy resources... 25 Indians 1 2010-04-01 2010-04-01 false How may a tribe assume management of development of different types of energy resources? 224.64 Section 224.64 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT...

  12. Validation of Fick cardiac output calculated with assumed oxygen consumption : a study of cardiac output during epoprostenol

    NARCIS (Netherlands)

    Bergstra, A; van den Heuvel, A F M; Zijlstra, F; Berger, R M F; Mook, G A; van Veldhuisen, D J

    2004-01-01

    OBJECTIVE: To test the validity of using assumed oxygen consumption for Fick cardiac output during administration of epoprostenol. METHODS: In 24 consecutive patients Fick cardiac output calculated with assumed oxygen consumption according to LaFarge and Miettinen (COLM) and according to Bergstra et

  13. 42 CFR 137.291 - May Self-Governance Tribes carry out construction projects without assuming these Federal...

    Science.gov (United States)

    2010-10-01

    ...-Governance Tribes carry out construction projects without assuming these Federal environmental... 42 Public Health 1 2010-10-01 2010-10-01 false May Self-Governance Tribes carry out construction projects without assuming these Federal environmental responsibilities? 137.291 Section 137.291...

  14. Self-other agreement and assumed similarity in neuroticism, extraversion, and trait affect: distinguishing the effects of form and content.

    Science.gov (United States)

    Beer, Andrew; Watson, David; McDade-Montez, Elizabeth

    2013-12-01

    Trait Negative Affect (NA) and Positive Affect (PA) are strongly associated with Neuroticism and Extraversion, respectively. Nevertheless, measures of the former tend to show substantially weaker self-other agreement-and stronger assumed similarity correlations-than scales assessing the latter. The current study separated the effects of item content versus format on agreement and assumed similarity using two different sets of Neuroticism and Extraversion measures and two different indicators of NA and PA (N = 381 newlyweds). Neuroticism and Extraversion consistently showed stronger agreement than NA and PA; in addition, however, scales with more elaborated items yielded significantly higher agreement correlations than those based on single adjectives. Conversely, the trait affect scales yielded stronger assumed similarity correlations than the personality scales; these coefficients were strongest for the adjectival measures of trait affect. Thus, our data establish a significant role for both content and format in assumed similarity and self-other agreement.

  15. Self-dual solitons in a $CPT$-odd and Lorentz-violating gauged $O(3)$ sigma model

    CERN Document Server

    Casana, R; Ferreira, M M; Lazar, G

    2016-01-01

    We have performed a complete study of self-dual configurations in a $CPT$-odd and Lorentz-violating gauged $O(3)$ nonlinear sigma model. We have consistently implemented the Bogomol'nyi-Prasad-Sommerfield (BPS) formalism and obtained the correspondent differential first-order equations describing electrically charged self-dual configurations. The total energy and magnetic flux of the vortices, besides being proportional to the winding number, also depend explicitly on the Lorentz-violating coefficients belonging to the sigma sector. The total electrical charge is proportional to the magnetic flux such as it occurs in Chern-Simons models. The Lorentz violation in the sigma sector allows one to interpolate between Lorentz-violating versions of some sigma models: the gauged $O(3)$ sigma model and the Maxwell-Chern-Simons $O(3)$ sigma model. The Lorentz violation enhances the amplitude of the magnetic field and BPS energy density near the origin, augmenting the deviation in relation to the solutions deprived of L...

  16. Uncharged compactlike and fractional Lorentz-violating BPS vortices in the CPT-even sector of the standard model extension

    Science.gov (United States)

    Miller, C.; Casana, R.; Ferreira, M. M., Jr.; da Hora, E.

    2012-09-01

    We have investigated and verified the existence of stable uncharged Bogomol’nyi-Prasad-Sommerfeld (BPS) vortices in the framework of an Abelian Maxwell-Higgs model supplemented with CPT-even and Lorentz-violating (LV) terms belonging to the gauge and Higgs sectors of the standard model extension. The analysis is performed in two situations: first, by considering the Lorentz violation only in the gauge sector, and then in both gauge and Higgs sectors. In the first case, it is observed that the model supports vortices somehow equivalent to the ones appearing in a dielectric medium. The Lorentz violation controls the radial extension (core of the solution) and the magnetic field amplitude of the Abrikosov-Nielsen-Olesen vortices, yielding compactlike defects in an alternative and simpler way than that of k-field models. At the end, we consider the Lorentz-violating terms in the gauge and Higgs sectors. It is shown that the full model also supports compactlike uncharged BPS vortices in a modified vacuum, but this time there are two LV parameters controlling the defect structure. Moreover, an interesting novelty is introduced by the LV-Higgs sector: fractional vortex solutions.

  17. Finite temperature behavior of the CPT-even and parity-even electrodynamics of the standard model extension

    Science.gov (United States)

    Casana, Rodolfo; Ferreira, Manoel M., Jr.; Rodrigues, Josberg S.; Silva, Madson R. O.

    2009-10-01

    In this work, we examine the finite temperature properties of the CPT-even and Lorentz-invariance-violating (LIV) electrodynamics of the standard model extension, represented by the term WανρφFανFρφ. We begin analyzing the Hamiltonian structure following the Dirac’s procedure for constrained systems and construct a well-defined and gauge invariant partition function in the functional integral formalism. Next, we specialize for the nonbirefringent coefficients of the tensor Wανρφ. In the sequel, the partition function is explicitly carried out for the parity-even sector of the tensor Wανρφ. The modified partition function is a power of the Maxwell’s partition function. It is observed that the LIV coefficients induce an anisotropy in the black body angular energy density distribution. The Planck’s radiation law, however, retains its frequency dependence and the Stefan-Boltzmann law keeps the usual form, except for a change in the Stefan-Boltzmann constant by a factor containing the LIV contributions.

  18. Performance monitoring and executive control of attention in euthymic bipolar disorder: employing the CPT-AX paradigm.

    Science.gov (United States)

    Robinson, Lucy J; Thompson, Jill M; Gallagher, Peter; Gray, John M; Young, Allan H; Ferrier, I Nicol

    2013-12-15

    Reduced cognitive test performance has been demonstrated in patients with bipolar disorder (BD), even when euthymic. Several studies have explored aspects of attention, including sustained attention, and reported patients show lower accuracy compared to controls. It is necessary to modify existing attentional paradigms to fully characterise such deficits. The present study sought to examine if there are changes in the profile of performance and error-types during a sustained attention task in BD. Twenty-two euthymic patients with DSM-IV diagnosed BD and 21 healthy controls were recruited. Participants completed a modified CPT-AX paradigm with a high proportion of target trials (70%) with cues and probes presented at continuous intervals. This modification increases the demands on response inhibition and permits the deconstruction of attentional/executive deficits previously described. Overall, BD patients showed significantly poorer target discriminability compared to controls. In block one (first quarter) of the task, patients showed no significant differences to controls, but by the final fourth block (last quarter) they made significantly fewer hits and more errors (both 'AX' misses and 'BX' false alarms). BD patients completed initial stages of the task similarly to controls, but as demands on the attentional system continued difficulties emerged, consistent with problems in context-maintenance.

  19. Tests of CPT symmetry in B0-B0bar mixing and in B0 to c cbar K0 decays

    CERN Document Server

    Schubert, Klaus R

    2016-01-01

    Using the time dependences for the decays Y(4S) to B0B0bar to (ell^+- X)(c cbar K_S,L), we determine the three CPT-sensitive parameters Re (z) and Im (z) in B0-B0bar mixing and |Abar/A| in B0 to c cbar K0 decays. We find Im(z) = 0.010 +- 0.030 +- 0013, Re(z) = -0:065 +- 0.028 +- 0.014, and |Abar/A| = 0.999 +- 0.023 +- 0.017, in agreement with CPT symmetry. The Re(z) result provides a limit on one component of Lorentz-symmetry violation.

  20. Pay attention to impulsivity: modelling low attentive and high impulsive subtypes of adult ADHD in the 5-choice continuous performance task (5C-CPT) in female rats.

    Science.gov (United States)

    Tomlinson, Anneka; Grayson, Ben; Marsh, Samuel; Harte, Michael K; Barnes, Samuel A; Marshall, Kay M; Neill, Joanna C

    2014-08-01

    Varying levels of attention and impulsivity deficits are core features of the three subtypes of adult attention deficit-hyperactivity disorder (ADHD). To date, little is known about the neurobiological correlates of these subtypes. Development of a translational animal model is essential to improve our understanding and improve therapeutic strategies. The 5-choice continuous performance task (5C-CPT) in rats can be used to examine different forms of attention and impulsivity. Adult rats were trained to pre-set 5C-CPT criterion and subsequently separated into subgroups according to baseline levels of sustained attention, vigilance, premature responding and response disinhibition in the 5C-CPT. The behavioural subgroups were selected to represent the different subtypes of adult ADHD. Consequently, effects of the clinically used pharmacotherapies (methylphenidate and atomoxetine) were assessed in the different subgroups. Four subgroups were identified: low-attentive (LA), high-attentive (HA), high-impulsive (HI) and low-impulsive (LI). Methylphenidate and atomoxetine produced differential effects in the subgroups. Methylphenidate increased sustained attention and vigilance in LA animals, and reduced premature responding in HI animals. Atomoxetine also improved sustained attention and vigilance in LA animals, and reduced response disinhibition and premature responding in HI animals. This is the first study using adult rats to demonstrate the translational value of the 5C-CPT to select subgroups of rats, which may be used to model the subtypes observed in adult ADHD. Our findings suggest that this as an important paradigm to increase our understanding of the neurobiological underpinnings of adult ADHD-subtypes and their response to pharmacotherapy.

  1. Lower Expression of SLC27A1 Enhances Intramuscular Fat Deposition in Chicken via Down-Regulated Fatty Acid Oxidation Mediated by CPT1A

    Science.gov (United States)

    Qiu, Fengfang; Xie, Liang; Ma, Jing-e; Luo, Wen; Zhang, Li; Chao, Zhe; Chen, Shaohao; Nie, Qinghua; Lin, Zhemin; Zhang, Xiquan

    2017-01-01

    Intramuscular fat (IMF) is recognized as the predominant factor affecting meat quality due to its positive correlation with tenderness, juiciness, and flavor. Chicken IMF deposition depends on the balance among lipid synthesis, transport, uptake, and subsequent metabolism, involving a lot of genes and pathways, however, its precise molecular mechanisms remain poorly understood. In the present study, the breast muscle tissue of female Wenchang chickens (WC) (higher IMF content, 1.24 in D120 and 1.62 in D180) and female White Recessive Rock chickens (WRR; lower IMF content, 0.53 in D120 and 0.90 in D180) were subjected to RNA-sequencing (RNA-seq) analysis. Results showed that many genes related to lipid catabolism, such as SLC27A1, LPL, ABCA1, and CPT1A were down-regulated in WC chickens, and these genes were involved in the PPAR signaling pathway and formed an IPA® network related to lipid metabolism. Furthermore, SLC27A1 was more down-regulated in WRR.D180.B than in WRR.D120.B. Decreased cellular triglyceride (TG) and up-regulated CPT1A were observed in the SLC27A1 overexpression QM-7 cells, and increased cellular triglyceride (TG) and down-regulated CPT1A were observed in the SLC27A1 knockdown QM-7 cells. These results suggest that lower lipid catabolism exists in WC chickens but not in WRR chickens, and lower expression of SLC27A1 facilitate IMF deposition in chicken via down-regulated fatty acid oxidation mediated by CPT1A. These findings indicate that reduced lipid catabolism, rather than increased lipid anabolism, contributes to chicken IMF deposition. PMID:28706492

  2. Thymoquinone induces caspase-independent, autophagic cell death in CPT-11-resistant lovo colon cancer via mitochondrial dysfunction and activation of JNK and p38.

    Science.gov (United States)

    Chen, Ming-Cheng; Lee, Nien-Hung; Hsu, Hsi-Hsien; Ho, Tsung-Jung; Tu, Chuan-Chou; Hsieh, Dennis Jine-Yuan; Lin, Yueh-Min; Chen, Li-Mien; Kuo, Wei-Wen; Huang, Chih-Yang

    2015-02-11

    Chemotherapy causes unwanted side effects and chemoresistance, limiting its effectiveness. Therefore, phytochemicals are now used as alternative treatments. Thymoquinone (TQ) is used to treat different cancers, including colon cancer. The irinotecan-resistant (CPT-11-R) LoVo colon cancer cell line was previously constructed by stepwise CPT-11 challenges to untreated parental LoVo cells. TQ dose-dependently increased the total cell death index and activated apoptosis at 2 μM, which then diminished at increasing doses. The possibility of autophagic cell death was then investigated. TQ caused mitochondrial outer membrane permeability (MOMP) and activated autophagic cell death. JNK and p38 inhibitors (SP600125 and SB203580, respectively) reversed TQ autophagic cell death. TQ was also found to activate apoptosis before autophagy, and the direction of cell death was switched toward autophagic cell death at initiation of autophagosome formation. Therefore, TQ resulted in caspase-independent, autophagic cell death via MOMP and activation of JNK and p38 in CPT-11-R LoVo colon cancer cells.

  3. Topological self-dual configurations in a Maxwell–Higgs model with a CPT-odd and Lorentz-violating nonminimal coupling

    Energy Technology Data Exchange (ETDEWEB)

    Casana, Rodolfo, E-mail: rodolfo.casana@gmail.com; Ferreira, Manoel M., E-mail: manojr.ufma@gmail.com; Mota, Alexsandro Lucena, E-mail: lucenalexster@gmail.com

    2016-12-15

    We have studied the existence of topological self-dual configurations in a nonminimal CPT-odd and Lorentz-violating (LV) Maxwell–Higgs model, where the LV interaction is introduced by modifying the minimal covariant derivative. The Bogomol’nyi–Prasad–Sommerfield formalism has been implemented, revealing that the scalar self-interaction implying self-dual equations contains a derivative coupling. The CPT-odd self-dual equations describe electrically neutral configurations with finite total energy proportional to the total magnetic flux, which differ from the charged solutions of other CPT-odd and LV models previously studied. In particular, we have investigated the axially symmetrical self-dual vortex solutions altered by the LV parameter. For large distances, the profiles possess general behavior similar to the vortices of Abrikosov–Nielsen–Olesen. However, within the vortex core, the profiles of the magnetic field and energy can differ substantially from ones of the Maxwell–Higgs model depending if the LV parameter is negative or positive.

  4. Topological self-dual configurations in a Maxwell-Higgs model with a CPT-odd and Lorentz-violating nonminimal coupling

    Science.gov (United States)

    Casana, Rodolfo; Ferreira, Manoel M.; Mota, Alexsandro Lucena

    2016-12-01

    We have studied the existence of topological self-dual configurations in a nonminimal CPT-odd and Lorentz-violating (LV) Maxwell-Higgs model, where the LV interaction is introduced by modifying the minimal covariant derivative. The Bogomol'nyi-Prasad-Sommerfield formalism has been implemented, revealing that the scalar self-interaction implying self-dual equations contains a derivative coupling. The CPT-odd self-dual equations describe electrically neutral configurations with finite total energy proportional to the total magnetic flux, which differ from the charged solutions of other CPT-odd and LV models previously studied. In particular, we have investigated the axially symmetrical self-dual vortex solutions altered by the LV parameter. For large distances, the profiles possess general behavior similar to the vortices of Abrikosov-Nielsen-Olesen. However, within the vortex core, the profiles of the magnetic field and energy can differ substantially from ones of the Maxwell-Higgs model depending if the LV parameter is negative or positive.

  5. Limits on the Lifetime Difference of Neutral B Mesons and on CP, T, and CPT Violation in B0-B0bar Mixing

    CERN Document Server

    Aubert, Bernard; Boutigny, D; Gaillard, J M; Hicheur, A; Karyotakis, Yu; Lees, J P; Robbe, P; Tisserand, V; Zghiche, A; Palano, A; Pompili, A; Chen, J C; Qi, N D; Rong, G; Wang, P; Zhu, Y S; Eigen, G; Ofte, I; Stugu, B; Abrams, G S; Borgland, A W; Breon, A B; Brown, D N; Button-Shafer, J; Cahn, R N; Charles, E; Day, C T; Gill, M S; Gritsan, A V; Groysman, Y; Jacobsen, R G; Kadel, R W; Kadyk, J; Kerth, L T; Kolomensky, Yu G; Kral, J F; Kukartsev, G; Le Clerc, C; Levi, M E; Lynch, G; Mir, L M; Oddone, P J; Orimoto, T J; Pripstein, M; Roe, N A; Romosan, A; Ronan, Michael T; Shelkov, V G; Telnov, A V; Wenzel, W A; Harrison, T J; Hawkes, C M; Knowles, D J; Penny, R C; Watson, A T; Watson, N K; Deppermann, T; Goetzen, K; Koch, H; Lewandowski, B; Pelizaeus, M; Peters, K; Schmücker, H; Steinke, M; Barlow, N R; Bhimji, W; Boyd, J T; Chevalier, N; Cottingham, W N; MacKay, C; Wilson, F F; Hearty, C; Mattison, T S; McKenna, J A; Thiessen, D; Kyberd, P; McKemey, A K; Blinov, V E; Bukin, A D; Golubev, V B; Ivanchenko, V N; Kravchenko, E A; Onuchin, A P; Serednyakov, S I; Skovpen, Yu I; Solodov, E P; Yushkov, A N; Best, D; Chao, M; Kirkby, D; Lankford, A J; Mandelkern, M A; McMahon, S; Mommsen, R K; Röthel, W; Stoker, D P; Buchanan, C; Hadavand, H K; Hill, E J; MacFarlane, D B; Paar, H P; Rahatlou, S; Schwanke, U; Sharma, V; Berryhill, J W; Campagnari, C; Dahmes, B; Kuznetsova, N; Levy, S L; Long, O; Lu, A; Mazur, M A; Richman, J D; Verkerke, W; Beringer, J; Eisner, A M; Heusch, C A; Lockman, W S; Schalk, T; Schmitz, R E; Schumm, B A; Seiden, A; Turri, M; Walkowiak, W; Williams, D C; Wilson, M G; Albert, J; Chen, E; Dorsten, M P; Dubois-Felsmann, G P; Dvoretskii, A; Hitlin, D G; Narsky, I; Porter, F C; Ryd, A; Samuel, A; Yang, S; Jayatilleke, S M; Mancinelli, G; Meadows, B T; Sokoloff, M D; Barillari, T; Blanc, F; Bloom, P; Clark, P J; Ford, W T; Nauenberg, U; Olivas, A; Rankin, P; Roy, J; Smith, J G; Van Hoek, W C; Zhang, L; Harton, J L; Hu, T; Soffer, A; Toki, W H; Wilson, R J; Zhang, J; Altenburg, D; Brandt, T; Brose, J; Colberg, T; Dickopp, M; Dubitzky, R S; Hauke, A; Lacker, H M; Maly, E; Müller-Pfefferkorn, R; Nogowski, R; Otto, S; Schubert, Klaus R; Schwierz, R; Spaan, B; Wilden, L; Bernard, D; Bonneaud, G R; Brochard, F; Cohen-Tanugi, J; Thiebaux, C; Vasileiadis, G; Verderi, M; Khan, A; Lavin, D; Muheim, F; Playfer, S; Swain, J E; Tinslay, J; Bozzi, C; Piemontese, L; Sarti, A; Treadwell, E; Anulli, F; Baldini-Ferroli, R; Calcaterra, A; De Sangro, R; Falciai, D; Finocchiaro, G; Patteri, P; Peruzzi, I M; Piccolo, M; Zallo, A; Buzzo, A; Contri, R; Crosetti, G; Lo Vetere, M; Macri, M; Monge, M R; Passaggio, S; Pastore, F C; Patrignani, C; Robutti, E; Santroni, A; Tosi, S; Bailey, S; Morii, M; Grenier, G J; Lee, S J; Mallik, U; Cochran, J; Crawley, H B; Lamsa, J; Meyer, W T; Prell, S; Rosenberg, E I; Yi, J; Davier, M; Grosdidier, G; Höcker, A; Laplace, S; Le Diberder, F R; Lepeltier, V; Lutz, A M; Petersen, T C; Plaszczynski, S; Schune, M H; Tantot, L; Wormser, G; Bionta, R M; Brigljevic, V; Cheng, C H; Lange, D J; Wright, D M; Bevan, A J; Fry, J R; Gabathuler, Erwin; Gamet, R; Kay, M; Payne, D J; Sloane, R J; Touramanis, C; Aspinwall, M L; Bowerman, D A; Dauncey, P D; Egede, U; Eschrich, I; Morton, G W; Nash, J A; Sanders, P; Taylor, G P; Back, J J; Bellodi, G; Harrison, P F; Shorthouse, H W; Strother, P; Vidal, P B; Cowan, G; Flächer, H U; George, S; Green, M G; Kurup, A; Marker, C E; McMahon, T R; Ricciardi, S; Salvatore, F; Vaitsas, G; Winter, M A; Brown, D; Davis, C L; Allison, J; Barlow, R J; Forti, A C; Hart, P A; Jackson, F; Lafferty, G D; Lyon, A J; Weatherall, J H; Williams, J C; Farbin, A; Jawahery, A; Kovalskyi, D; Lae, C K; Lillard, V; Roberts, D A; Blaylock, G; Dallapiccola, C; Flood, K T; Hertzbach, S S; Kofler, R; Koptchev, V B; Moore, T B; Stängle, H; Willocq, S; Cowan, R; Sciolla, G; Taylor, F; Yamamoto, R K; Mangeol, D J J; Milek, M; Patel, P M; Lazzaro, A; Palombo, F; Bauer, J M; Cremaldi, L M; Eschenburg, V; Godang, R; Kroeger, R; Reidy, J; Sanders, D A; Summers, D J; Zhao, H W; Hast, C; Taras, P; Nicholson, H; Cartaro, C; Cavallo, N; De Nardo, Gallieno; Fabozzi, F; Gatto, C; Lista, L; Paolucci, P; Piccolo, D; Sciacca, C; Baak, M A; Raven, G; LoSecco, J M; Gabriel, T A; Brau, B; Pulliam, T; Brau, J E; Frey, R; Iwasaki, M; Potter, C T; Sinev, N B; Strom, D; Torrence, E; Colecchia, F; Dorigo, A; Galeazzi, F; Margoni, M; Morandin, M; Posocco, M; Rotondo, M; Simonetto, F; Stroili, R; Tiozzo, G; Voci, C; Benayoun, M; Briand, H; Chauveau, J; David, P; La Vaissière, C de; Del Buono, L; Hamon, O; Leruste, P; Ocariz, J; Pivk, M; Roos, L; Stark, J; T'Jampens, S; Manfredi, P F; Re, V; Gladney, L; Guo, Q H; Panetta, J; Angelini, C; Batignani, G; Bettarini, S; Bondioli, M; Bucci, F; Calderini, G; Carpinelli, M; Forti, F; Giorgi, M A; Lusiani, A; Marchiori, G; Martínez-Vidal, F; Morganti, M; Neri, N; Paoloni, E; Rama, M; Rizzo, G; Sandrelli, F; Walsh, J; Haire, M; Judd, D; Paick, K; Wagoner, D E; Danielson, N; Elmer, P; Lü, C; Miftakov, V; Olsen, J; Smith, A J S; Varnes, E W; Bellini, F; Cavoto, G; Del Re, D; Faccini, R; Ferrarotto, F; Ferroni, F; Gaspero, M; Leonardi, E; Mazzoni, M A; Morganti, S; Pierini, M; Piredda, G; Safai-Tehrani, F; Serra, M; Voena, C; Christ, S; Wagner, G; Waldi, R; Adye, T; De Groot, N; Franek, B J; Geddes, N I; Gopal, G P; Olaiya, E O; Xella, S M; Aleksan, Roy; Emery, S; Gaidot, A; Ganzhur, S F; Giraud, P F; Hamel de Monchenault, G; Kozanecki, Witold; Langer, M; London, G W; Mayer, B; Schott, G; Vasseur, G; Yéche, C; Zito, M; Purohit, M V; Weidemann, A W; Yumiceva, F X; Aston, D; Bartoldus, R; Berger, N; Boyarski, A M; Buchmüller, O L; Convery, M R; Coupal, D P; Dong, D; Dorfan, J; Dujmic, D; Dunwoodie, W M; Field, R C; Glanzman, T; Gowdy, S J; Graugès-Pous, E; Hadig, T; Halyo, V; Hrynóva, T; Innes, W R; Jessop, C P; Kelsey, M H; Kim, P; Kocian, M L; Langenegger, U; Leith, D W G S; Luitz, S; Lüth, V; Lynch, H L; Marsiske, H; Menke, S; Messner, R; Müller, D R; O'Grady, C P; Ozcan, V E; Perazzo, A; Perl, M; Petrak, S; Ratcliff, B N; Robertson, S H; Roodman, A; Salnikov, A A; Schindler, R H; Schwiening, J; Simi, G; Snyder, A; Soha, A; Stelzer, J; Su, D; Sullivan, M K; Tanaka, H A; Vavra, J; Wagner, S R; Weaver, M; Weinstein, A J R; Wisniewski, W J; Wright, D H; Young, C C; Burchat, Patricia R; Meyer, T I; Roat, C; Ahmed, S; Ernst, J A; Bugg, W; Krishnamurthy, M; Spanier, S M; Eckmann, R; Kim, H; Ritchie, J L; Schwitters, R F; Izen, J M; Kitayama, I; Lou, X C; Ye, S; Bianchi, F; Bóna, M; Gallo, F; Gamba, D; Borean, C; Bosisio, L; Della Ricca, G; Dittongo, S; Grancagnolo, S; Lanceri, L; Poropat, P; Vitale, L; Vuagnin, G; Panvini, R S; Banerjee, Sw; Brown, C M; Fortin, D; Jackson, P D; Kowalewski, R V; Roney, J M; Band, H R; Dasu, S; Datta, M; Eichenbaum, A M; Hu, H; Johnson, J R; Liu, R; Di Lodovico, F; Mohapatra, A K; Pan, Y; Prepost, R; Sekula, S J; Von Wimmersperg-Töller, J H; Wu, J; Wu Sau Lan; Yu, Z; Neal, H

    2003-01-01

    Using events in which one of two neutral B mesons from the decay of an Y(4S) resonance is fully reconstructed, we set limits on the lifetime difference between the two neutral-B mass eigenstates and on CP, T, and CPT violation in B0-B0bar mixing. Both CP and non-CP eigenstates were obtained from the 88 million Y(4S)->B0B0bar decays collected between 1999 and 2002 with the BABAR detector at the PEP-II asymmetric-energy B-Factory at SLAC. We determine six independent parameters governing mixing (dm, dGamma/Gamma), CPT/CP violation (Re(z), Im(z)), and CP/T violation (Im\\lambda(CP), |q/p|), where \\lambda(CP) characterizes B0 and B0bar decays to states of charmonium plus K_S or K_L. The preliminary results are: sgn(Re\\lambda(CP))*dGamma/Gamma = -0.008+-0.037(stat)+-0.018(syst) [-0.084,0.068], |q/p| = 1.029+-0.013(stat)+-0.011(syst) [1.001,1.057], (Re\\lambda(CP)/|\\lambda (CP)|)*Rez = 0.014+-0.035(stat)+-0.034(syst) [-0.072,0.101], Imz = 0.038+-0.029(stat)+-0.025(syst) [-0.028, 0.104] . The values inside square brac...

  6. The neural circuitry supporting goal maintenance during cognitive control: a comparison of expectancy AX-CPT and dot probe expectancy paradigms.

    Science.gov (United States)

    Lopez-Garcia, Pilar; Lesh, Tyler A; Salo, Taylor; Barch, Deanna M; MacDonald, Angus W; Gold, James M; Ragland, J Daniel; Strauss, Milton; Silverstein, Steven M; Carter, Cameron S

    2016-02-01

    Goal maintenance is an aspect of cognitive control that has been identified as critical for understanding psychopathology according to criteria of the NIMH-sponsored CNTRICS (Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia) and Research Domain Criteria (RDoC) initiatives. CNTRICS proposed the expectancy AX-CPT, and its visual-spatial parallel the dot probe expectancy (DPX), as valid measures of the cognitive and neural processes thought to be relevant for goal maintenance. The goal of this study was to specifically examine the functional neural correlates and connectivity patterns of both goal maintenance tasks in the same subset of subjects to further validate their neural construct validity and clarify our understanding of the nature and function of the neural circuitry engaged by the tasks. Twenty-six healthy control subjects performed both the letter (AX) and dot pattern (DPX) variants of the CPT during fMRI. Behavioral performance was similar between tasks. The 2 tasks engaged the same brain networks including dorsolateral prefrontal cortex (DLPFC) and dorsal parietal regions, supporting their validity as complementary measures of the goal maintenance construct. Interestingly there was greater engagement of the frontal opercular insula region during the expectancy AX-CPT (letter) and greater functional connectivity between the PFC and medial temporal lobe in the DPX (dot pattern). These differences are consistent with differential recruitment of phonological and visual-spatial processes by the two tasks and suggest that additional long-term memory systems may be engaged by the dot probe version.

  7. Limits on the Lifetime Difference of Neutral B Mesons and on CP, T, and CPT Violation in B0-B0bar Mixing

    Energy Technology Data Exchange (ETDEWEB)

    Kirkby, David P.

    2003-03-27

    Using events in which one of two neutral B mesons from the decay of an {Upsilon}(4S) resonance is fully reconstructed, they set limits on the lifetime difference between the two neutral-B mass eigenstates and on CP, T, and CPT violation in B{sup 0}{bar B}{sup 0} mixing. Both CP and non-CP eigenstates were obtained from the 88 million {Upsilon}(4S) {yields} B{bar B} decays collected between 1999 and 2002 with the BABAR detector at the PEP-II asymmetric-energy B-Factory at SLAC. They determine six independent parameters governing mixing ({Delta}m, {Delta}{Lambda}/{Lambda}), CPT/CP violation (Rez, Imz), and CP/T violation (Im{lambda}{sub CP}, |q/p|), where {lambda}{sub CP} characterizes B{sup 0} and {bar B}{sup 0} decays to states of charmonium plus K{sub S}{sup 0} or K{sub L}{sup 0}.

  8. [Docetaxel (TXT) and irinotecan (CPT-11) as a second-line chemotherapy for platinum-pretreated squamous cell carcinoma of the head and neck].

    Science.gov (United States)

    Sakoda, Takema; Morizane, Rie; Nosaka, Aya; Nakahara, Kei; Fukutsuji, Kenji; Yamanishi, Mie; Ikeda, Hiroki; Shibano, Akira; Enomoto, Tadao; Kitano, Hiroya

    2008-08-01

    Cisplatin(CDDP), combined with 5-fluorouracil, is considered one of the most active chemotherapeutic combinations in the treatment of patients with squamous cell carcinoma of the head and neck(SCCHN)and is accepted today as a standard regimen. But second-line chemotherapy for platinum-pretreated patients has not yet been established. Eighteen patients with recurrent SCCHN were treated using docetaxel (TXT) and irinotecan (CPT-11). All of them had been pretreated with platinum included regimen. In principle, our regimen consisted of TXT(50-60 mg/m(2), day 1) and CPT-11(60-90 mg/m(2), day 1, 8, 15). The adverse events were significant, including 13(72.2%)of grade 3 and 4 neutropenia, but acceptable. Seventeen patients were eligible for evaluation of response. Two complete responses (CR; 11.8%)and 6 partial responses (PR; 35.3%)were observed with an overall response rate of 47.1%. Patients pretreated with TXT had a 25.0% response rate (1 PR and 3 progressive disease). We conclude that the combination of TXT and CPT-11 is a worthwhile treatment for platinum-pretreated SCCHN as a 2nd-line-chemotherapy.

  9. [An effective treatment by chemotherapy with CDDP+CPT-11 for recurrent gastric cancer which S-1 cannot be used owing to adverse effects].

    Science.gov (United States)

    Matsui, Toshihiro; Aoyagi, Haruhiko; Kaneko, Jun; Yoshida, Tsuyoshi; Hasegawa, Kumi; Isogai, Jun; Maejima, Shizuaki

    2013-11-01

    We report a case of a 64-year-old man with multiple lung metastases after gastric cancer surgery. This patient was initially treated with S-1. However, he experienced adverse effects, and subsequently, he was effectively treated with cisplatin (CDDP) and irinotecan (CPT-11). In July 2010, the patient experienced a decrease in appetite and underwent a detailed examination. He also underwent distal gastrectomy in the same month. The postoperative diagnosis was T4a( SE), N2, M0, Stage IIIB. In November 2010, adjuvant chemotherapy with S-1 was initiated. In February 2011, the patient developed a skin disorder( grade 3) and generalized edema along with walking difficulty, which were identified as adverse effects of S-1. Evidently, S-1 was contraindicated for this patient, and adjuvant therapy was discontinued. In September 2011, contrast -enhanced thoracoabdominal computed tomography( CT) was performed and para-aortic lymph node metastasis and multiple lung metastases were detected. CDDP+CPT-11 therapy was initiated. By June 2012, 8 courses had been administered, and the patient had a good partial response. With regard to chemotherapy for advanced or recurrent gastric cancer, there is no consensus on a treatment policy for cases in which S-1 cannot be used owing to adverse effects. CDDP+CPT-11 therapy is considered a safe and effective choice.

  10. 孕早期高中链脂肪酸膳食对子代CPT1的影响%Effect of high dietary intake of medium-chain fatty acids during the first trimester of pregnancy on CPT 1 of offspring

    Institute of Scientific and Technical Information of China (English)

    董艳梅; 孙长颢; 钞虹; 刘吉成

    2012-01-01

    Objective: To explore the effect of high dietary intake of medium - chain fatty (HMF) acids during the first trimester of pregnancy on obesity of offspring and obesity - related gene - carnitine palmityl transferase 1 ( CPT1 ) , and find out the target of preventing and treating obesity early and reasonable gestational diet. Methods: Wistar rats were fed with standard diet (SD) and high medium -chain fatty diet ( HMCFAD) during the first trimester of pregnancy, the female neonatal rats were divided into control group and HMF group, all the neonatal rats were fed to adult with SD afler stopping milk supply; the rats in control group were randomly divided into two groups; control group(SD) and high fatty control group ( HFC group) . Obese models of rats were established by using HMCFAD in HFC group and HMF group. The rats were killed, real - time polymerase chain reaction (PCR) was used to detect the expression of CPT1 mRNA. Results: Compared with control group and HFC group, body weight of rats in HMF group decreased significantly ( P < 0. 05) , the expression of CPT1 increased significantly. Conclusion: HMCFAD can increase the expression of CFT1 gene of offspring and reduce the occurrence of adulthood obesity.%目的:探讨孕早期高中链脂肪酸膳食(HMCFAD)对子代肥胖和肥胖相关基因肉毒碱棕榈酰基转移酶1(CPT1)表达的影响,寻找早期防治肥胖的靶标及合理的孕期膳食.方法:Wistar大鼠孕早期分别食用标准膳食(SD)和HMC-FAD,所产雄性子鼠分别为对照(CON)组和高中链脂肪酸(HMF)组,断乳后食用SD至成年;将CON组大鼠随机分为两组:CON组(食用SD)和高脂对照(HFC)组.HFC和HMF组大鼠高脂膳食诱导肥胖.分期处死大鼠取材,Real-Time PCR法检测骨骼肌中CPT1 mRNA的表达.结果:与CON和HFC组相比,HMF组大鼠的体重降低(P <0.05); CPT1表达持续升高.结论:孕早期HMCFAD可程序性升高子代CPT1基因的表达,降低成年肥胖的发生.

  11. Inversion assuming weak scattering

    DEFF Research Database (Denmark)

    Xenaki, Angeliki; Gerstoft, Peter; Mosegaard, Klaus

    2013-01-01

    The study of weak scattering from inhomogeneous media or interface roughness has long been of interest in sonar applications. In an acoustic backscattering model of a stationary field of volume inhomogeneities, a stochastic description of the field is more useful than a deterministic description...... due to the complex nature of the field. A method based on linear inversion is employed to infer information about the statistical properties of the scattering field from the obtained cross-spectral matrix. A synthetic example based on an active high-frequency sonar demonstrates that the proposed...

  12. The molecular, electronic, bonding, and photophysical features of the [(c-Pt3)Tl(c-Pt3)]+ inorganic metallocenes.

    Science.gov (United States)

    Tsipis, Athanassios C; Gkekas, George N

    2013-06-21

    The molecular, electronic, bonding and photophysical properties of a series of inorganic metallocenes with the general formula {[Pt3(μ2-L)3(L')3]2(μ6-Tl)}(+) (L = CO, CH3CN, PH2, C6F5, or SO2 and L' = CO, PH3, CH3CN, C6F5) have been studied by means of DFT electronic structure calculations. The estimated Tl-cd distances between Tl(+) cations and the centroids (cd) of the trimetallic Pt3(μ2-L)3(L')3 {3 : 3 : 3} decks were found in the range 2.932-3.397 Å. The predicted bond dissociation energy, D0, of the (c-Pt3)···Tl(+) bonds was found to lie within the range -31.5 up to -77.5 kcal mol(-1) at the B3LYP/LANL2TZ(f)(Pt) ∪ 6-31G(d,p)(E) ∪ SRLC(Tl) level of theory. Most of the [(c-Pt3)Tl(c-Pt3)](+) inorganic metallocenes adopt a bend titanocene-like structure. The Localized Orbital Locator (LOL) contour maps along with the 3D contour plots of the Reduced Gradient Density (RDG) mirror the composite nature of the interaction of Tl(+) with the triangular Pt3 metallic ring cores consisting of electrostatic, covalent and dispersion interaction components. The Pt3···Tl(+)···Pt3 bonding mode was further validated by Energy Decomposition Analysis (EDA) calculations which demonstrated that the electrostatic and covalent components of the interaction contribute almost equally to the bonding interactions. Furthermore, Charge Decomposition Analysis (CDA) and Natural Bond Orbital Analysis (NBO) calculations indicated that charge transfer from the Tl(+) cation to the Pt3(0) {3 : 3 : 3} decks also occurs. The {[Pt3(μ2-L)3(L')3]2(μ6-Tl)}(+) sandwiches absorb in the UV-Vis region (300-500 nm) and emit in the visible-near IR region (600-1000 nm). The absorption bands are mainly of MLCT/MC character while phosphorescence is predicted to occur via the first triplet excited state, T1, since the spin density of this excited state could be described as a SOMO - 1/SOMO combination. Generally, no significant distortions occur upon excitation of these systems

  13. A phase II experience with neoadjuvant irinotecan (CPT-11, 5-fluorouracil (5-FU and leucovorin (LV for colorectal liver metastases

    Directory of Open Access Journals (Sweden)

    Bigam David

    2009-05-01

    Full Text Available Abstract Background Chemotherapy may improve survival in patients undergoing resection of colorectal liver metastases (CLM. Neoadjuvant chemotherapy may help identify patients with occult extrahepatic disease (averting unnecessary metastasectomy, and it provides in vivo chemosensitivity data. Methods A phase II trial was initiated in which patients with resectable CLM received CPT-11, 5-FU and LV for 12 weeks. Metastasectomy was performed unless extrahepatic disease appeared. Postoperatively, patients with stable or responsive disease received the same regimen for 12 weeks. Patients with progressive disease received either second-line chemotherapy or best supportive care. The primary endpoint was disease-free survival (DFS; secondary endpoints included overall survival (OS and safety. Results 35 patients were accrued. During preoperative chemotherapy, 16 patients (46% had grade 3/4 toxicities. Resection was not possible in 5 patients. One patient died of arrhythmia following surgery, and 1 patient had transient liver failure. During the postoperative treatment phase, 12 patients (55% had grade 3/4 toxicities. Deep venous thrombosis (DVT occurred in 11 patients (34% at various times during treatment. Of those who underwent resection, median DFS was 23.0 mo. and median OS has not been reached. The overall survival from time of diagnosis of liver metastases was 51.6 mo for the entire cohort. Conclusion A short course of chemotherapy prior to hepatic metastasectomy may serve to select candidates best suited for resection and it may also direct postoperative systemic treatment. Given the significant incidence of DVT, alternative systemic neoadjuvant regimens should be investigated, particularly those that avoid the use of a central venous line. Trial Registration ClinicalTrials.gov NCT00168155.

  14. 9 CFR 72.15 - Owners assume responsibility; must execute agreement prior to dipping or treatment waiving all...

    Science.gov (United States)

    2010-01-01

    ....15 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE INTERSTATE TRANSPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS TEXAS (SPLENETIC) FEVER IN... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Owners assume responsibility;...

  15. 42 CFR 137.286 - Do Self-Governance Tribes become Federal agencies when they assume these Federal environmental...

    Science.gov (United States)

    2010-10-01

    ... Self-Governance Tribes are required to assume Federal environmental responsibilities for projects in... performing these Federal environmental responsibilities, Self-Governance Tribes will be considered the... 42 Public Health 1 2010-10-01 2010-10-01 false Do Self-Governance Tribes become Federal...

  16. 42 CFR 137.300 - Since Federal environmental responsibilities are new responsibilities, which may be assumed by...

    Science.gov (United States)

    2010-10-01

    ... Federal environmental responsibilities assumed by the Self-Governance Tribe. ... 42 Public Health 1 2010-10-01 2010-10-01 false Since Federal environmental responsibilities are... additional funds available to Self-Governance Tribes to carry out these formerly inherently...

  17. High mortality risk among individuals assumed to be TB-negative can be predicted using a simple test

    DEFF Research Database (Denmark)

    Rabna, Paulo; Andersen, Andreas; Wejse, Christian

    2009-01-01

    OBJECTIVES: To determine mortality among assumed TB negative (aTBneg) individuals in Guinea-Bissau and to investigate whether plasma levels of soluble urokinase receptor (suPAR) can be used to determine post-consultation mortality risk. METHODS: This prospective West-African cohort study included...

  18. Is it reasonable to assume a uniformly distributed cooling-rate along the microslide of a directional solidification stage?

    Science.gov (United States)

    Rabin

    2000-10-01

    It is commonly assumed that the cooling-rate along the microslide of a directional solidification stage is uniformly distributed, an assumption which is typically applied in low cooling-rates studies. A new directional solidification stage has recently been presented, which is specified to achieve high cooling-rates of up to 1.8 x 104 degrees C min-1, where cooling-rates are still assumed to be uniformly distributed. The current study presents a closed-form solution to the temperature distribution and to the cooling-rate in the microslide. Thermal analysis shows that the cooling-rate is by no means uniformly distributed and can vary by several hundred percent along the microslide in some cases. Therefore, the mathematical solution presented in this study is essential for experimental planning of high cooling-rate experiments.

  19. Development and validation of reversed phase liquid chromatographic method utilizing ultraviolet detection for quantification of irinotecan (CPT-11) and its active metabolite, SN-38, in rat plasma and bile samples: application to pharmacokinetic studies.

    Science.gov (United States)

    Bansal, Tripta; Awasthi, Anshumali; Jaggi, Manu; Khar, Roop K; Talegaonkar, Sushama

    2008-09-15

    A new, simple, sensitive and specific reversed-phase high performance liquid chromatographic (HPLC) method using ultraviolet detection was developed and validated for the analysis of CPT-11 (lambda(max)=254 nm, 365 nm) and its major active metabolite, SN-38 (lambda(max)=380 nm) in rat plasma and bile. The sample pre-treatment from plasma involved a single protein precipitation step with cold acetonitrile. In case of bile, liquid-liquid extraction with dichloromethane: tert-butyl methyl ether (3:7) was carried out. Topotecan, a structurally related camptothecin, was used as an internal standard. An aliquot of 50 microL was injected onto a C-18 column. The chromatographic separation was achieved by gradient elution consisting of acetonitrile and water (pH 3.0 adjusted with 20% o-phosphoric acid) at a flow rate of 1.0 ml/min. Total run time for each sample was 30 min. All the analytes viz. topotecan, CPT-11, SN-38 were well separated with retention times of 11.4, 13.4 and 15.5 min, respectively. Method was found to be selective, linear (R(2) approximately 0.999), accurate (recovery+/-15%) and precise (<5% C.V.) in the selected concentration ranges for both the analytes. The quantification limit for CPT-11 was 40 ngml(-1) and for SN-38 was 25 ngml(-1). The percent extraction efficiency was approximately 97% for CPT-11 and SN-38 from plasma while extraction recovery of CPT-11 and SN-38 from bile was approximately 70% and approximately 60%, respectively. The method was successfully used to determine plasma and biliary excretion time profiles of CPT-11 and SN-38, following oral and intravenous CPT-11 administration in rats. In the present study, irinotecan showed an absolute bioavailability of 30% as calculated from the pharmacokinetic data.

  20. Treatment of human colon cancer xenografts with TRA-8 anti-death receptor 5 antibody alone or in combination with CPT-11.

    Science.gov (United States)

    Oliver, Patsy G; LoBuglio, Albert F; Zinn, Kurt R; Kim, Hyunki; Nan, Li; Zhou, Tong; Wang, Wenquan; Buchsbaum, Donald J

    2008-04-01

    This study was designed to evaluate the in vitro cytotoxicity and in vivo efficacy of TRA-8, a mouse monoclonal antibody that binds to the DR5 death receptor for tumor necrosis factor-related apoptosis-inducing ligand (also called Apo2L), alone and in combination with CPT-11, against human colon cancer cells and xenografts. DR5 expression was assessed on human colon cancer cell lines using flow cytometry, and cellular cytotoxicity after TRA-8 treatment, alone and in combination with SN-38, was determined by measuring cellular ATP levels. Tumor growth inhibition and regression rates of well-established subcutaneous COLO 205, SW948, HCT116, and HT-29 colon cancer xenografts in athymic nude mice treated with TRA-8 or CPT-11 alone and in combination were determined. (99m)Tc-TRA-8 was used to examine tumor localization of TRA-8 in animals bearing each of the four xenografts. In addition, whole-body biodistribution and imaging was carried out in COLO 205-bearing animals using in vivo single-photon emission computed tomography imaging and tissue counting. DR5 expression was highest on HCT116, intermediate on SW948 and COLO 205 cells, and lowest on HT-29 cells. COLO 205 cells were the most sensitive to TRA-8-induced cytotoxicity in vitro, SW948 and HCT116 cell lines were moderately sensitive, and HT-29 cells were resistant. Combination treatment with TRA-8 and SN-38 produced additive to synergistic cytotoxicity against all cell lines compared with either single agent. The levels of apoptosis in all cell lines, including HT-29, were increased by combination treatment with SN-38. In vivo, combination therapy with TRA-8 and CPT-11 was superior to either single-agent regimen for three of the xenografts: COLO 205, SW948, and HCT116. COLO 205 tumors were most responsive to therapy with 73% complete regressions after combination therapy. HT-29 cells derived no antitumor efficacy from TRA-8 therapy. Tumor xenografts established from the four colon cancer cell lines had comparable

  1. Analysis of results of IVA-CPT for 100 children with ADHD diagnosis%ADHD儿童100例IVA-CPT测试结果分析

    Institute of Scientific and Technical Information of China (English)

    李影; 岳亿玲; 魏晓春

    2012-01-01

    目的 探讨视听整合连续执行测试(IVA-CPT)在临床诊断儿童注意力缺陷多动障碍(ADHD)中的应用.方法 对2009 年1 月-2010 年12 月我院多动症门诊主诉以多动、注意力不集中的、符合ADHD 诊断标准的100例儿童进行IVA-CPT 测试,对其结果 进行分析.结果 男童中注意缺陷型占28%,多动型占45%,混合型占27%;女童中注意缺陷型占40%,多动型占25%,混合型占35%.差异有显著性(P<0.005).男童的综合反应控制商数和综合注意力商数分别为80.50±20.01和66.93±17.30;女童的综合反应控制商数和综合注意力商数分别为86.45±19.50和64.54±15.20,各项数值比较,差异均有显著性(P<0.01).结论 IVA-CPT 是一种对儿童ADHD 具有诊断价值的客观检查方法.

  2. Study of T and CPT symmetries in semileptonic disintegrations of kaons neutral K{sup 0} and anti K{sup 0}; Etude des symetries T et CPT dans les desintegrations semileptoniques des kaons neutres K{sup 0} et anti K{sup 0}

    Energy Technology Data Exchange (ETDEWEB)

    Soares-Svagelski, A.

    1996-06-05

    This thesis begins by a presentation of the different symmetries such P, C, T, CP and CPT. Then, there is a phenomenon description of violation parameters of T, CPT and CP in the system of kaons neutral, the study system. It is shown how the violation of CP has been introduced in the super weak model then, in the standard model. Then, we have a description of the experience called CP LEAR with the presentation of apparatus and devices and the data acquisition. Before the analysis of semileptonic events, the selection of these events is detailed. The determination of parameters is followed by a discussion of gained values. The other measures of the experience are only little discussed. (N.C.). 67 refs., 65 figs., 14 tabs.

  3. Addendum: Classical solutions for the parity-even sector of the CPT-even term of the standard model extension gauge sector

    CERN Document Server

    Casana, Rodolfo; Gomes, A R; Pinheiro, Paulo R D

    2008-01-01

    In this work, we focus on some properties of the parity-even sector of the CPT-even term of the standard model extension. We analyze how the six non-birefringent terms belonging to this sector modify the the static and stationary classical solutions of the usual Maxwell theory. We observe that the parity-even terms do not couple the electric and magnetic sectors (at least in the stationary regime). The Green method is used to obtain solutions for the field strengths E and B at first order in the LV parameters. Explicit solutions are attained for pointlike and spatially extended sources, for which a dipolar expansion is achieved.

  4. New cancer-treatment model of photodynamic therapy combined with a type I topoisomerase inhibitor, CPT-11, against HeLa cell tumors in nude mice used by OPO parametric tunable laser

    Science.gov (United States)

    Yoshida, Takato O.; Matsuzawa, Eiji; Matsuo, Tetsumichi; Koide, Yukio; Terakawa, Susumu; Yokokura, Teruo; Hirano, Toru

    1995-03-01

    A new cancer-treatment model, photodynamic therapy (PDT) combined with a type I topoisomerase inhibitor, camptothecin derivative (CPT-11), against HeLa cell tumors in BALB/c nude mice has been developed using a wide-band tunable coherent light source operated on optical parametric oscillation (OPO parametric tunable laser). The Photosan-3 PDT and CPT-11 combined therapy was remarkably effective, that is the inhibition rate (I.R.) 40 - 80%, as compared to PDT only in vivo. The analysis of HpD (Photosan-3) and CPT-11 effects on cultured HeLa cells in vitro has been studied by a video-enhanced contrast differential interference contrast microscope (VEC-DIC). Photosan-3 with 600 nm light killed cells by mitochondrial damage within 50 min, but not with 700 nm light. CPT-11 with 700 - 400 nm light killed cells within 50 min after nucleolus damage appeared after around 30 min. The localization of CPT-11 in cells was observed as fluorescence images in the nucleus, particularly the nucleoral area produced clear images using an Argus 100.

  5. Comparing nadir and limb observations of polar mesospheric clouds: The effect of the assumed particle size distribution

    Science.gov (United States)

    Bailey, Scott M.; Thomas, Gary E.; Hervig, Mark E.; Lumpe, Jerry D.; Randall, Cora E.; Carstens, Justin N.; Thurairajah, Brentha; Rusch, David W.; Russell, James M.; Gordley, Larry L.

    2015-05-01

    Nadir viewing observations of Polar Mesospheric Clouds (PMCs) from the Cloud Imaging and Particle Size (CIPS) instrument on the Aeronomy of Ice in the Mesosphere (AIM) spacecraft are compared to Common Volume (CV), limb-viewing observations by the Solar Occultation For Ice Experiment (SOFIE) also on AIM. CIPS makes multiple observations of PMC-scattered UV sunlight from a given location at a variety of geometries and uses the variation of the radiance with scattering angle to determine a cloud albedo, particle size distribution, and Ice Water Content (IWC). SOFIE uses IR solar occultation in 16 channels (0.3-5 μm) to obtain altitude profiles of ice properties including the particle size distribution and IWC in addition to temperature, water vapor abundance, and other environmental parameters. CIPS and SOFIE made CV observations from 2007 to 2009. In order to compare the CV observations from the two instruments, SOFIE observations are used to predict the mean PMC properties observed by CIPS. Initial agreement is poor with SOFIE predicting particle size distributions with systematically smaller mean radii and a factor of two more albedo and IWC than observed by CIPS. We show that significantly improved agreement is obtained if the PMC ice is assumed to contain 0.5% meteoric smoke by mass, in agreement with previous studies. We show that the comparison is further improved if an adjustment is made in the CIPS data processing regarding the removal of Rayleigh scattered sunlight below the clouds. This change has an effect on the CV PMC, but is negligible for most of the observed clouds outside the CV. Finally, we examine the role of the assumed shape of the ice particle size distribution. Both experiments nominally assume the shape is Gaussian with a width parameter roughly half of the mean radius. We analyze modeled ice particle distributions and show that, for the column integrated ice distribution, Log-normal and Exponential distributions better represent the range

  6. On Integral Upper Limits Assuming Power-law Spectra and the Sensitivity in High-energy Astronomy

    Science.gov (United States)

    Ahnen, Max L.

    2017-02-01

    The high-energy non-thermal universe is dominated by power-law-like spectra. Therefore, results in high-energy astronomy are often reported as parameters of power-law fits, or, in the case of a non-detection, as an upper limit assuming the underlying unseen spectrum behaves as a power law. In this paper, I demonstrate a simple and powerful one-to-one relation of the integral upper limit in the two-dimensional power-law parameter space into the spectrum parameter space and use this method to unravel the so-far convoluted question of the sensitivity of astroparticle telescopes.

  7. Phase field modeling of brittle fracture for enhanced assumed strain shells at large deformations: formulation and finite element implementation

    Science.gov (United States)

    Reinoso, J.; Paggi, M.; Linder, C.

    2017-02-01

    Fracture of technological thin-walled components can notably limit the performance of their corresponding engineering systems. With the aim of achieving reliable fracture predictions of thin structures, this work presents a new phase field model of brittle fracture for large deformation analysis of shells relying on a mixed enhanced assumed strain (EAS) formulation. The kinematic description of the shell body is constructed according to the solid shell concept. This enables the use of fully three-dimensional constitutive models for the material. The proposed phase field formulation integrates the use of the (EAS) method to alleviate locking pathologies, especially Poisson thickness and volumetric locking. This technique is further combined with the assumed natural strain method to efficiently derive a locking-free solid shell element. On the computational side, a fully coupled monolithic framework is consistently formulated. Specific details regarding the corresponding finite element formulation and the main aspects associated with its implementation in the general purpose packages FEAP and ABAQUS are addressed. Finally, the applicability of the current strategy is demonstrated through several numerical examples involving different loading conditions, and including linear and nonlinear hyperelastic constitutive models.

  8. Phase field modeling of brittle fracture for enhanced assumed strain shells at large deformations: formulation and finite element implementation

    Science.gov (United States)

    Reinoso, J.; Paggi, M.; Linder, C.

    2017-06-01

    Fracture of technological thin-walled components can notably limit the performance of their corresponding engineering systems. With the aim of achieving reliable fracture predictions of thin structures, this work presents a new phase field model of brittle fracture for large deformation analysis of shells relying on a mixed enhanced assumed strain (EAS) formulation. The kinematic description of the shell body is constructed according to the solid shell concept. This enables the use of fully three-dimensional constitutive models for the material. The proposed phase field formulation integrates the use of the (EAS) method to alleviate locking pathologies, especially Poisson thickness and volumetric locking. This technique is further combined with the assumed natural strain method to efficiently derive a locking-free solid shell element. On the computational side, a fully coupled monolithic framework is consistently formulated. Specific details regarding the corresponding finite element formulation and the main aspects associated with its implementation in the general purpose packages FEAP and ABAQUS are addressed. Finally, the applicability of the current strategy is demonstrated through several numerical examples involving different loading conditions, and including linear and nonlinear hyperelastic constitutive models.

  9. Reasons People Surrender Unowned and Owned Cats to Australian Animal Shelters and Barriers to Assuming Ownership of Unowned Cats.

    Science.gov (United States)

    Zito, Sarah; Morton, John; Vankan, Dianne; Paterson, Mandy; Bennett, Pauleen C; Rand, Jacquie; Phillips, Clive J C

    2016-01-01

    Most cats surrendered to nonhuman animal shelters are identified as unowned, and the surrender reason for these cats is usually simply recorded as "stray." A cross-sectional study was conducted with people surrendering cats to 4 Australian animal shelters. Surrenderers of unowned cats commonly gave surrender reasons relating to concern for the cat and his/her welfare. Seventeen percent of noncaregivers had considered adopting the cat. Barriers to assuming ownership most commonly related to responsible ownership concerns. Unwanted kittens commonly contributed to the decision to surrender for both caregivers and noncaregivers. Nonowners gave more surrender reasons than owners, although many owners also gave multiple surrender reasons. These findings highlight the multifactorial nature of the decision-making process leading to surrender and demonstrate that recording only one reason for surrender does not capture the complexity of the surrender decision. Collecting information about multiple reasons for surrender, particularly reasons for surrender of unowned cats and barriers to assuming ownership, could help to develop strategies to reduce the number of cats surrendered.

  10. Limits on the Decay-Rate Difference of Neutral-B Mesons and on CP, T, and CPT Violation in B0-antiB0 Oscillations

    CERN Document Server

    Aubert, Bernard; Abrams, G S; Adye, T; Ahmed, S; Alam, M S; Albert, J; Aleksan, Roy; Allison, J; Allmendinger, T; Altenburg, D; Andreotti, M; Angelini, C; Aston, D; Azzolini, V; Baak, M; Back, J J; Bailey, S; Baldini-Ferroli, R; Band, H R; Banerjee, Sw; Barate, R; Bard, D J; Barlow, N R; Barlow, R J; Bartoldus, R; Batignani, G; Bauer, J M; Beck, T W; Behera, P K; Bellini, F; Benayoun, M; Berger, N; Bernard, D; Berryhill, J W; Best, D; Bettarini, S; Bettoni, D; Bevan, A J; Bhimji, W; Bianchi, F; Blanc, F; Blaylock, G; Blinov, V E; Bloom, P; Bóna, M; Bondioli, M; Bonneaud, G R; Borean, C; Borgland, A W; Bosisio, L; Boutigny, D; Bowerman, D A; Boyarski, A M; Boyd, J T; Bozzi, C; Brandenburg, G; Brandt, T; Brau, B; Brau, J E; Breon, A B; Briand, H; Brochard, F; Brose, J; Brown, C L; Brown, C M; Brown, D N; Bruinsma, M; Brunet, S; Bucci, F; Buchmüller, O L; Bugg, W; Bukin, A D; Bulten, H J; Burchat, Patricia R; Button-Shafer, J; Buzzo, A; Côté, D; Cahn, R N; Calabrese, R; Calcaterra, A; Calderini, G; Campagnari, C; Capra, R; Carpinelli, M; Cartaro, C; Cavallo, N; Cavoto, G; Chao, M; Charles, E; Chauveau, J; Chen, A; Chen, E; Chen, J C; Chen, S; Cheng, C H; Chevalier, N; Christ, S; Cibinetto, G; Clark, P J; Cochran, J; Colberg, T; Colecchia, F; Coleman, J P; Contri, R; Convery, M R; Cormack, C M; Cossutti, F; Cottingham, W N; Couderc, F; Cowan, G; Cowan, R; Crawley, H B; Cremaldi, L M; Cristinziani, M; Crosetti, G; Çuhadar-Dönszelmann, T; Dahmes, B; Dallapiccola, C; Danielson, N; Dasu, S; Datta, M; Dauncey, P D; David, P; Davier, M; Davis, D; Day, C T; De Groot, N; De Nardo, Gallieno; Del Buono, L; Del Gamba, V; Della Ricca, G; Di Lodovico, F; Dickopp, M; Dittongo, S; Dong, D; Dorfan, J; Dorigo, A; Druzhinin, V P; Dubois-Felsmann, G P; Dujmic, D; Dunwoodie, W M; Dvoretskii, A; Eckmann, R; Edwards, A J; Egede, U; Eichenbaum, A M; Eigen, G; Eisner, A M; Elmer, P; Elsen, E E; Emery, S; Ernst, J A; Eschenburg, V; Eschrich, I; Fabozzi, F; Faccini, R; Fan, S; Farbin, A; Feltresi, E; Ferrarotto, F; Ferroni, F; Field, R C; Finocchiaro, G; Flack, R L; Flächer, H U; Flood, K T; Ford, K; Ford, W T; Forti, F; Fortin, D; Franek, B J; Frey, R; Fritsch, M; Fry, J R; Gabathuler, Erwin; Gabriel, T A; Gaidot, A; Gaillard, J M; Gaillard, J R; Galeazzi, F; Gallo, F; Gamba, D; Gamet, R; Gan, K K; Ganzhur, S F; Gary, J W; Gaspero, M; Gatto, C; Geddes, N I; Gill, M S; Giorgi, M A; Giraud, P F; Gladney, L; Glanzman, T; Godang, R; Goetzen, K; Golubev, V B; Gopal, G P; Gowdy, S J; Grancagnolo, S; Green, M G; Grenier, P; Gritsan, A V; Grosdidier, G; Groysman, Y; Guo, Q H; Hadavand, H K; Hadig, T; Haire, M; Halyo, V; Hamel de Monchenault, G; Hamon, O; Harrison, P F; Harrison, T J; Hart, P A; Hartfiel, C; Buchanan, B L; Harton, J L; Hast, C; Hauke, A; Hawkes, C M; Hearty, C; Held, T; Hertzbach, S S; Heusch, C A; Hicheur, A; Hill, E J; Hitlin, D G; Höcker, A; Hodgkinson, M C; Hollar, J J; Honscheid, K; Hrynóva, T; Hufnagel, D; Hulsbergen, W D; Igonkina, O; Innes, W R; Ivanchenko, V N; Izen, J M; Jackson, P D; Jacobsen, R G; Jawahery, A; Jayatilleke, S M; John, M J J; Johnson, J R; Judd, D; Kadel, R W; Kadyk, J; Kagan, H; Karyotakis, Yu; Kass, R; Kelly, M P; Kelsey, M H; Kerth, L T; Khan, A; Kim, H; Kim, P; Kirkby, D; Kitayama, I; Koch, H; Kocian, M L; Kofler, R; Kolomensky, Yu G; Koptchev, V B; Kovalskyi, D; Kowalewski, R V; Kozanecki, Witold; Kravchenko, E A; Krishnamurthy, M; Kroeger, R; Kukartsev, G; Kutter, P E; Lacker, H M; Lae, C K; Lafferty, G D; Lamsa, J; Lanceri, L; Lange, D J; Langenegger, R S; Dubitzky, U; Langer, M; Lankford, A J; Laplace, S; Latham, T E; Lavin, D; Le Clerc, C; Le Diberder, F R; Lees, J P; Legendre, M; Leith, D W G S; Lepeltier, V; Leruste, P; Levesque, J A; Levy, S L; Lewandowski, B; Li Gioi, L; Li, H; Libby, J; Lillard, V; Lista, L; Liu, R; Lo Secco, C P; Jessop, J M; Lo Vetere, M; Lockman, W S; London, G W; Long, O; Lou, X C; Lu, A; Lü, C; Luitz, S; Luppi, E; Lusiani, A; Lüth, V; Lutz, A M; Lynch, G; Lynch, H L; Lyon, A J; MacFarlane, D B; Macri, M; Mallik, G J; Grenier, U; Maly, E; Mancinelli, G; Mandelkern, M A; Mangeol, D J J; Marchiori, G; Margoni, M; Marker, C E; Marsiske, H; Martínez-Vidal, F; Mattison, T S; Mayer, B; Mazur, M A; Mazzoni, M A; McKenna, J A; McMahon, T R; Meadows, B T; Merchant, A M; Messner, R; Meyer, T I; Meyer, W T; Miftakov, V; Mihályi, A; Mir, L M; Mohanty, G B; Mohapatra, A K; Mommsen, R K; Monge, M R; Monorchio, D; Moore, T B; Morandin, M; Morgan, S E; Morganti, M; Morganti, S; Morii, M; Morton, G W; Muheim, F; Müller, D R; Müller-Pfefferkorn, R; Narsky, I; Nash, J A; Nauenberg, U; Neal, H; Negrini, M; Neri, N; Nicholson, H; Nogowski, R; O'Grady, C P; Ocariz, J; Oddone, P J; Ofte, I; Olaiya, E O; Olivas, A; Olsen, J; Onuchin, A P; Orimoto, T J; Otto, S; Ozcan, V E; Paar, H P; Paick, K; Palombo, A; Lazzaro, F; Pan, Y; Panetta, J; Panvini, R S; Paoloni, E; Paolucci, P; Parry, R J; Passaggio, S; Patel, P M; Patrignani, C; Patteri, P; Payne, D J; Pelizaeus, M; Perazzo, A; Perl, M; Peruzzi, F; Anulli, I M; Petersen, B A; Petersen, T C; Petrak, S; Petzold, A; Piatenko, T; Piccolo, D; Piccolo, M; Piemontese, L; Pierini, M; Pioppi, M; Biasini, M; Piredda, G; Pivk, M; Plaszczynski, S; Playfer, S; Pompili, A; Palano, A; Poropat, P; Porter, F C; Posocco, M; Potter, C T; Prell, S; Prepost, R; Pripstein, M; Pulliam, T; Purohit, M V; Qi, N D; Rahatlou, S; Rahimi, A M; Rama, M; Rankin, P; Ratcliff, B N; Raven, G; Re, P F; Manfredi, V R; Reidy, J; Ricciardi, S; Richman, J D; Ritchie, J L; Rizzo, G; Roat, C; Roberts, D A; Robertson, S H; Robutti, E; Roe, N A; Röthel, W; Ronan, Michael T; Roney, J M; Rong, G; Roodman, A; Roos, L; Rosenberg, E I; Rotondo, M; Ryd, A; Saeed, M A; Tehrani, F S; Saleem, M; Salnikov, A A; Salvatore, F; Samuel, A; Sanders, D A; Sandrelli, F; Santroni, A; Saremi, S; Sarti, A; Satpathy, A; Schalk, T; Schindler, R H; Schmitz, R E; Schott, G; Schrenk, S; Schubert, J; Schubert, Klaus R; Schumm, B A; Schune, M H; Schwiening, J; Schwierz, R; Schwitters, R F; Sciacca, C; Sciolla, G; Seiden, A; Sekula, S J; Serednyakov, S I; Sharma, V; Shelkov, V G; Shen, B C; Simani, M C; Simi, G; Simonetto, F; Sinev, N B; Skovpen, Yu I; Sloane, R J; Smith, A J S; Smith, J G; Snyder, A; Soffer, A; Soha, A; Sokoloff, M D; Solodov, E P; Spaan, B; Spanier, S M; Spradlin, P; Stängle, H; Steinke, M; Stelzer, J; Stoker, D P; Stroili, R; Strom, D; Stugu, B; Su, D; Sullivan, M K; Summers, D J; Sundermann, J E; T'Jampens, S; Tan, P; Tantot, L; Taras, P; Taylor, F; Taylor, G P; Telnov, A V; Teodorescu, P; Kyberd, L; Ter-Antonian, R; Therin, G; Thiebaux, C; Thiessen, D; Tiozzo, G; Tisserand, V; Toki, W H; Torrence, E; Tosi, S; Touramanis, C; Treadwell, E; Vaitsas, G; Vasileiadis, G; Vasseur, G; Vavra, J; Verderi, M; Verkerke, W; Vitale, L; Voci, C; Voena, C; Vuagnin, G; Wagner, G; Wagner, S R; Wagoner, D E; Waldi, R; Walsh, J; Wang, K; Wang, P; Wappler, F R; Watson, A T; Weaver, M; Weidemann, A W; Weinstein, A J R; Wenzel, W A; Wilden, L; Williams, D C; Williams, J C; Willocq, S; Wilson, F F; Wilson, M G; Wilson, R J; Winter, M A; Wisniewski, W J; Wittgen, M; Won, E; Wong, Q K; Wormser, G; Wright, D H; Wright, D M; Wu, J; Wu Sau Lan; Yamamoto, R K; Yang, S; Yarritu, A K; Ye, S; Yéche, C; Yi, J; Young, C C; Yu, Z; Yumiceva, F X; Yushkov, A N; Zallo, A; Zeng, Q L; Zghiche, A; Zhang, L; Zhao, H W; Zhu, Y S; Zito, M; De Sangro, R; Del Re, D; La Vaissière, C de; Von Wimmersperg-Töller, J H

    2004-01-01

    Using events in which one of two neutral-B mesons from the decay of an Y(4S) resonance is fully reconstructed, we set limits on the difference between the decay rates of the two neutral-B mass eigenstates and on CP, T, and CPT violation in B0-antiB0 mixing. The reconstructed decays, comprising both CP and flavor eigenstates, are obtained from 88 million Y(4S) --> Banti-B decays collected with the BABAR detector at the PEP-II asymmetric-energy B Factory at SLAC. We determine six independent parameters governing oscillations (Deltam, DeltaGamma/Gamma), CPT and CP violation (Re Z, Im Z), and CP and T violation (Im lambdaCP, |q/p|), where lambdaCP characterizes B0 and anti-B0 decays to states of charmonium plus K0S or K0L. The results are sgn(Re lambdaCP)xDeltaGamma/Gamma = -0.008 +/- 0.037(stat) +/- 0.018(syst) [-0.084,0.068], |q/p| = 1.029 +/- 0.013(stat) +/- 0.011(syst) [ 1.001,1.057], (Re lambdaCP)/|lambdaCP|xRe z = 0.014 +/- 0.035(stat) +/- 0.034(syst) [-0.072,0.101], Im z = 0.038 +/- 0.029(stat) +/- 0.025(s...

  11. Polymorphism located between CPT1B and CHKB, and HLA-DRB1*1501-DQB1*0602 haplotype confer susceptibility to CNS hypersomnias (essential hypersomnia.

    Directory of Open Access Journals (Sweden)

    Taku Miyagawa

    Full Text Available BACKGROUND: SNP rs5770917 located between CPT1B and CHKB, and HLA-DRB1*1501-DQB1*0602 haplotype were previously identified as susceptibility loci for narcolepsy with cataplexy. This study was conducted in order to investigate whether these genetic markers are associated with Japanese CNS hypersomnias (essential hypersomnia: EHS other than narcolepsy with cataplexy. PRINCIPAL FINDINGS: EHS was significantly associated with SNP rs5770917 (P(allele = 3.6x10(-3; OR = 1.56; 95% c.i.: 1.12-2.15 and HLA-DRB1*1501-DQB1*0602 haplotype (P(positivity = 9.2x10(-11; OR = 3.97; 95% c.i.: 2.55-6.19. No interaction between the two markers (SNP rs5770917 and HLA-DRB1*1501-DQB1*0602 haplotype was observed in EHS. CONCLUSION: CPT1B, CHKB and HLA are candidates for susceptibility to CNS hypersomnias (EHS, as well as narcolepsy with cataplexy.

  12. A case of bone metastasis of colon cancer that markedly responded to S-1/CPT-11 combination chemotherapy and became curable by resection

    Directory of Open Access Journals (Sweden)

    Masuda Hideki

    2006-01-01

    Full Text Available Abstract Background An oral combined fluoropyrimidine anticancer drug, tegafur/gimeracil/oteracil potassium (S-1, has recently been used alone or in combination for colon cancer. Case presentation The patient was a 42-year-old man with sigmoid colon cancer with direct invasion of the urinary bladder and multiple costal metastases. A diagnosis of T4, M1, stage IV sigmoid colon cancer was made, and curative resection was considered impossible. S-1 at 50 mg/m2 was administered by oral route from day 1 to day 14. Irinotecan (CPT-11 at 40 mg/m2 was administered by intravenous day 1 and 15. This treatment was followed by 2 weeks absent period, and repeated every 4 weeks. Six cycles of administration were performed in total. Following this treatment, the multiple costal metastases resolved. Down-staging to T3, M0, stage IIA was achieved, and curative resection was judged to be possible. Conclusion Occasional cases in which S-1/CPT-11 therapy was effective have been recently reported. The patient's tumor became resectable despite the discovery of colon cancer associated with bone metastasis at the initial examination, offering hope for cancer patients.

  13. Acetyl-L-carnitine supplementation reverses the age-related decline in carnitine palmitoyltransferase 1 (CPT1) activity in interfibrillar mitochondria without changing the L-carnitine content in the rat heart.

    Science.gov (United States)

    Gómez, Luis A; Heath, Shi-Hua D; Hagen, Tory M

    2012-01-01

    The aging heart displays a loss of bioenergetic reserve capacity partially mediated through lower fatty acid utilization. We investigated whether the age-related impairment of cardiac fatty acid catabolism occurs, at least partially, through diminished levels of L-carnitine, which would adversely affect carnitine palmitoyltransferase 1 (CPT1), the rate-limiting enzyme for fatty acyl-CoA uptake into mitochondria for β-oxidation. Old (24-28 mos) Fischer 344 rats were fed±acetyl-L-carnitine (ALCAR; 1.5% [w/v]) for up to four weeks prior to sacrifice and isolation of cardiac interfibrillar (IFM) and subsarcolemmal (SSM) mitochondria. IFM displayed a 28% (pcarnitine. ALCAR supplementation restored CPT1 activity in heart IFM, but not apparently through remediation of L-carnitine levels. Rather, ALCAR influenced enzyme activity over time, potentially by modulating conditions in the aging heart that ultimately affect palmitoyl-CoA binding and CPT1 kinetics.

  14. Search for CPT Violation with the FOCUS Experiment and Measurement of Λb lifetime in the decay Λb → J / Ψ Lambda with the D0 Experiment

    Energy Technology Data Exchange (ETDEWEB)

    Kryemadhi, Abaz [Indiana Univ., Bloomington, IN (United States)

    2004-12-01

    This dissertation describes two different projects from two different experiments. We have performed a search for CPT violation in neutral charm meson oscillations using data from the FOCUS Experiment. While flavor mixing in the charm sector is predicted to be small in the Standard Model, it is still possible to investigate CPT violation through a study of the proper time dependence of a CPT asymmetry in right-sign decay rates for D0 → K- π+ and $\\bar{D}$0 → K+π-. This asymmetry is related to the CPT violating complex parameter ξ and the mixing parameters x and y: ACPT ∞ Reξy - Imξx. We determine a 95% confidence level limit of -0.0068 < Reξy - Imξx < 0.0234. Within the framework of the Standard Model Extension incorporating general CPT violation, we also find 95% confidence level limits for the expressions involving coefficients of Lorentz violation of (-2.8 < N(x,y,δ))(Δa0 + 0.6 ΔaZ< 4.8) x 10-16 GeV, (-7.0 < N(x,y,δ)Δax < 3.8) x 10-16 GeV, and (-7.0 < N(x,y,δ)Δay < 3.8) x 10-16 GeV, where N(x,y,δ) is a normalization factor that incorporates mixing parameters x, y and the doubly Cabibbo suppressed to Cabibbo favored relative strong phase δ.

  15. Explicit theory of mind is even more unified than previously assumed: belief ascription and understanding aspectuality emerge together in development.

    Science.gov (United States)

    Rakoczy, Hannes; Bergfeld, Delia; Schwarz, Ina; Fizke, Ella

    2015-01-01

    Existing evidence suggests that children, when they first pass standard theory-of-mind tasks, still fail to understand the essential aspectuality of beliefs and other propositional attitudes: such attitudes refer to objects only under specific aspects. Oedipus, for example, believes Yocaste (his mother) is beautiful, but this does not imply that he believes his mother is beautiful. In three experiments, 3- to 6-year-olds' (N = 119) understanding of aspectuality was tested with a novel, radically simplified task. In contrast to all previous findings, this task was as difficult as and highly correlated with a standard false belief task. This suggests that a conceptual capacity more unified than previously assumed emerges around ages 4-5, a full-fledged metarepresentational scheme of propositional attitudes.

  16. Attitude assumed by nurses in regards to end of life decisions of people: Case of Costa Rica, 2011

    Directory of Open Access Journals (Sweden)

    Jerik Andrade Espinales

    2012-10-01

    Full Text Available The research problem was to analyze what is the attitude assumed by nurses in regards to end of life decisions of people in Costa Rica during 2011. A quantitative exploratory and transactional methodology was developed, with a random sample and a subsample multistage taking into account the national hospitals Class A; obtaining a sample of 86 nursing professionals who completed a questionnaire. The obtained data was tabulated using a statistical package. The data demonstrated that although most of the participants were unfamiliar with the concept of end of life decisions, they related the said concept to the respect for the dignity, the rights and the autonomy of people in the same way they apply such ethical values when providing care. The research team concluded that the sampled nursing professionals favored the mentioned ethical values over their own personal ethics and morals.

  17. 重整热力学理论的方案%Assume of Reconstructing the Thermodynamic Theory

    Institute of Scientific and Technical Information of China (English)

    何沛平; 朱顶余

    2012-01-01

    “热寂说”是热力学第二定律的宇宙学推论,由于涉及到宇宙未来、人类命运等重大问题,引起了科学界和哲学界一百多年持续不断的争论.本文从重力场影响介质温度分布出发,研究系统处于外力场中的热力学规律,给出重整热力学理论的方案,该方案涉及到热力学第二定律、第零定律、热流定律.重整后的热力学定律更具普适性.%"Heat Death" is the second law of thermodynamics cosmological inferences. As it relates to the future of the universe and the destiny of mankind, the scientific community and the philosophical community have debated hundred years. A famous scholar pointed out that " With gravitation, thermodynamics should how to reconstruct? "in the article "why not heat death " . In order to study the subject, based on force field affecting the medium temperature, we study thermodynamics laws when the system staying in the external force field, obtaining the reconstructing assume of the thermodynamic theory. The assume is related to the second law of thermodynamics, zero law, heat flow law. After the reconstructing, the law of thermodynamics is more universal.

  18. Forage preservation (grazing vs. hay fed to ewes affects the fatty acid profile of milk and CPT1B gene expression in the sheep mammary gland

    Directory of Open Access Journals (Sweden)

    Dervishi Elda

    2012-07-01

    Full Text Available Abstract Background Alterations in lipid metabolism occur when animals are exposed to different feeding systems. In the last few decades, the characterisation of genes involved in fat metabolism and technological advances have enabled the study of the effect of diet on the milk fatty acid (FA profile in the mammary gland and aided in the elucidation of the mechanisms of the response to diet. The aim of this study was to evaluate the effect of different forage diets (grazing vs. hay near the time of ewe parturition on the relationship between the fatty acid profile and gene expression in the mammary gland of the Churra Tensina sheep breed. Results In this study, the forage type affected the C18:2 cis-9 trans-11 (CLA and long-chain saturated fatty acid (LCFA content, with higher percentages during grazing than during hay feeding. This may suggest that these FAs act as regulatory factors for the transcriptional control of the carnitine palmitoyltransferase 1B (CPT1B gene, which was more highly expressed in the grazing group (GRE. The most highly expressed gene in the mammary gland at the fifth week of lactation is CAAT/ enhancer- binding protein beta (CEBPB, possibly due to its role in milk fat synthesis in the mammary gland. More stable housekeeping genes in the ovine mammary gland that would be appropriate for use in gene expression studies were ribosomal protein L19 (RPL19 and glyceraldehyde- 3- phosphate dehydrogenase (GAPDH. Conclusions Small changes in diet, such as the forage preservation (grazing vs. hay, can affect the milk fatty acid profile and the expression of the CPT1B gene, which is associated with the oxidation of fatty acids. When compared to hay fed indoors, grazing fresh low mountain pastures stimulates the milk content of CLA and LCFA via mammary uptake. In this sense, LCFA in milk may be acting as a regulatory factor for transcriptional control of the CPT1B gene, which was more highly expressed in the grazing group.

  19. The canonical Luminous Blue Variable AG Car and its neighbor Hen 3-519 are much closer than previously assumed

    CERN Document Server

    Smith, Nathan

    2016-01-01

    The strong mass loss of Luminous Blue Variables (LBVs) is thought to play a critical role in the evolution of massive stars, but the physics of their instability and their place in the evolutionary sequence remains uncertain and debated. A key to understanding their peculiar instability is their high observed luminosity, which for Galactic LBVs often depends on an uncertain distance estimate. Here we report direct distances and space motions of four canonical Milky Way LBVs---AG Car, HR Car, HD 168607, and (the LBV candidate) Hen 3-519---whose parallaxes and proper motions have been provided by the Gaia first data release. Whereas the distances of HR Car and HD 168607 are consistent with those previously adopted in the literature within the uncertainty, we find that the distances to Hen 3-519 and AG Car, both at $\\sim$2 kpc, are much closer than the 6--8 kpc distances previously assumed. For Hen 3-519, this moves the star far from the locus of LBVs on the HR Diagram. AG Car has been considered a defining exam...

  20. Importance of the habitat choice behavior assumed when modeling the effects of food and temperature on fish populations

    Science.gov (United States)

    Wildhaber, Mark L.; Lamberson, Peter J.

    2004-01-01

    Various mechanisms of habitat choice in fishes based on food and/or temperature have been proposed: optimal foraging for food alone; behavioral thermoregulation for temperature alone; and behavioral energetics and discounted matching for food and temperature combined. Along with development of habitat choice mechanisms, there has been a major push to develop and apply to fish populations individual-based models that incorporate various forms of these mechanisms. However, it is not known how the wide variation in observed and hypothesized mechanisms of fish habitat choice could alter fish population predictions (e.g. growth, size distributions, etc.). We used spatially explicit, individual-based modeling to compare predicted fish populations using different submodels of patch choice behavior under various food and temperature distributions. We compared predicted growth, temperature experience, food consumption, and final spatial distribution using the different models. Our results demonstrated that the habitat choice mechanism assumed in fish population modeling simulations was critical to predictions of fish distribution and growth rates. Hence, resource managers who use modeling results to predict fish population trends should be very aware of and understand the underlying patch choice mechanisms used in their models to assure that those mechanisms correctly represent the fish populations being modeled.

  1. Distance determination for RAVE stars using stellar models II: Most likely values assuming a standard stellar evolution scenario

    CERN Document Server

    Zwitter, T; Breddels, M A; Smith, M C; Helmi, A; Munari, U; Bienaym\\'{e), O; Bland-Hawthorn, J; Boeche, C; Brown, A G A; Campbell, R; Freeman, K C; Fulbright, J; Gibson, B; Gilmore, G; Grebel, E K; Navarro, J F; Parker, Q A; Seabroke, G M; Siebert, A; Siviero, A; Steinmetz, M; Watson, F G; Williams, M; Wyse, R F G

    2010-01-01

    The RAdial Velocity Experiment (RAVE) is a spectroscopic survey of the Milky Way. We use the subsample of spectra with spectroscopically determined values of stellar parameters to determine the distances to these stars. The list currently contains 235,064 high quality spectra which show no peculiarities and belong to 210,872 different stars. The numbers will grow as the RAVE survey progresses. The public version of the catalog will be made available through the CDS services along with the ongoing RAVE public data releases. The distances are determined with a method based on the work by Breddels et al.~(2010). Here we assume that the star undergoes a standard stellar evolution and that its spectrum shows no peculiarities. The refinements include: the use of either of the three isochrone sets, a better account of the stellar ages and masses, use of more realistic errors of stellar parameter values, and application to a larger dataset. The derived distances of both dwarfs and giants match within ~21% to the astr...

  2. Controlling a transfer trajectory with realistic impulses assumming perturbations in the Sun-Earth-Moon Quasi-Bicircular Problem

    Science.gov (United States)

    Leiva, A. M.; Briozzo, C. B.

    In a previous work we successfully implemented a control algorithm to stabilize unstable periodic orbits in the Sun-Earth-Moon Quasi-Bicircular Problem (QBCP). Applying the same techniques, in this work we stabilize an unstable trajectory performing fast transfers between the Earth and the Moon in a dynamical system similar to the QBCP but incorporating the gravitational perturbation of the planets Mercury, Venus, Mars, Jupiter, Saturn, Uranus, and Neptune, assumed to move on circular coplanar heliocentric orbits. In the control stage we used as a reference trajectory an unstable periodic orbit from the unperturbed QBCP. We performed 400 numerical experiments integrating the trajectories over time spans of ~40 years, taking for each one random values for the initial positions of the planets. In all cases the control impulses applied were larger than 20 cm/s, consistently with realistic implementations. The minimal and maximal yearly mean consumptions were ~10 m/s and ~71 m/s, respectively. FULL TEXT IN SPANISH

  3. Stationary solutions for the parity-even sector of the CPT-even and Lorentz-covariance-violating term of the standard model extension

    Energy Technology Data Exchange (ETDEWEB)

    Casana, Rodolfo; Ferreira, Manoel M.; Pinheiro, Paulo R.D. [Universidade Federal do Maranhao (UFMA), Departamento de Fisica, Sao Luis, MA (Brazil); Gomes, A.R. [Centro Federal de Educacao Tecnologica do Maranhao, Departamento de Ciencias Exatas, Sao Luis, Maranhao (Brazil)

    2009-08-15

    In this work, we focus on some properties of the parity-even sector of the CPT-even electrodynamics of the standard model extension. We analyze how the six non-birefringent terms belonging to this sector modify the static and stationary classical solutions of the usual Maxwell theory. We observe that the parity-even terms do not couple the electric and magnetic sectors (at least in the stationary regime). The Green's method is used to obtain solutions for the field strengths E and B at first order in the Lorentz-covariance-violating parameters. Explicit solutions are attained for point-like and spatially extended sources, for which a dipolar expansion is achieved. Finally, an Earth-based experiment is presented that can lead (in principle) to an upper bound on the anisotropic coefficients as stringent as ({kappa}{sub e-}){sup ij}<2.9 x 10{sup -20}. (orig.)

  4. Stationary solutions for the parity-even sector of the CPT-even and Lorentz-covariance-violating term of the standard model extension

    Science.gov (United States)

    Casana, Rodolfo; Ferreira, Manoel M.; Gomes, A. R.; Pinheiro, Paulo R. D.

    2009-08-01

    In this work, we focus on some properties of the parity-even sector of the CPT-even electrodynamics of the standard model extension. We analyze how the six non-birefringent terms belonging to this sector modify the static and stationary classical solutions of the usual Maxwell theory. We observe that the parity-even terms do not couple the electric and magnetic sectors (at least in the stationary regime). The Green’s method is used to obtain solutions for the field strengths E and B at first order in the Lorentz-covariance-violating parameters. Explicit solutions are attained for point-like and spatially extended sources, for which a dipolar expansion is achieved. Finally, an Earth-based experiment is presented that can lead (in principle) to an upper bound on the anisotropic coefficients as stringent as left(widetilde{kappa}_{e-}right)^{ij}<2.9×10^{-20}.

  5. A prospective randomized study of irinotecan (CPT-11), leucovorin (LV) and 5-fluorouracil (5FU) versus leucovorin and 5-fluorouracil in patients with advanced colorectal carcinoma.

    Science.gov (United States)

    Gennatas, C; Papaxoinis, G; Michalaki, V; Mouratidou, D; Andreadis, C; Tsavaris, N; Pafiti, A

    2006-10-01

    The purpose of this study was to compare the activity and toxicity of an irinotecan (CPT-11), leucovorin (LV) and 5-fluorouracil (5FU) combination with a standard regimen of 5FU and LV, in patients with advanced colorectal carcinoma. One hundred and sixty patients were randomized; 80 patients (group A) received LV 20 mg/m(2) bolus i.v. and 5FU 425 mg/m(2) bolus i.v. on days 1-5, every 28 days; 80 patients (group B) received CPT-11 80 mg/m(2) (30-90 min i.v. infusion), followed by LV 20 mg/m(2) bolus i.v. and 5FU 425 mg/m(2) bolus i.v. on days 1, 8, 15, 22, 29, and 36, every 8 weeks. The overall response rate was 30% and 47.5% in groups A and B respectively. Progression-free survival was significantly higher in the triple-drug combination arm (median 7.5 vs. 4.5 months; p= 0. 0335). However, overall survival did not differ significantly between the two arms (15 months vs. 14 months for the groups B and A respectively; p=0.3531). The main grade 3 adverse events were diarrhea (19%, in group A vs. 35% in group B; p=0.032) and mucositis (2% vs. 14%; p=0.017). The regimen containing irinotecan showed activity in advanced colorectal cancer. The overall safety data confirm this combination as a well-tolerated treatment.

  6. Activation of the aryl hydrocarbon receptor by carbaryl: Computational evidence of the ability of carbaryl to assume a planar conformation.

    Science.gov (United States)

    Casado, Susana; Alonso, Mercedes; Herradón, Bernardo; Tarazona, José V; Navas, José

    2006-12-01

    It has been accepted that aryl hydrocarbon receptor (AhR) ligands are compounds with two or more aromatic rings in a coplanar conformation. Although general agreement exists that carbaryl is able to activate the AhR, it has been proposed that such activation could occur through alternative pathways without ligand binding. This idea was supported by studies showing a planar conformation of carbaryl as unlikely. The objective of the present work was to clarify the process of AhR activation by carbaryl. In rat H4IIE cells permanently transfected with a luciferase gene under the indirect control of AhR, incubation with carbaryl led to an increase of luminescence. Ligand binding to the AhR was studied by means of a cell-free in vitro system in which the activation of AhR can occur only by ligand binding. In this system, exposure to carbaryl also led to activation of AhR. These results were similar to those obtained with the AhR model ligand beta-naphthoflavone, although this compound exhibited higher potency than carbaryl in both assays. By means of computational modeling (molecular mechanics and quantum chemical calculations), the structural characteristics and electrostatic properties of carbaryl were described in detail, and it was observed that the substituent at C-1 and the naphthyl ring were not coplanar. Assuming that carbaryl would interact with the AhR through a hydrogen bond, this interaction was studied computationally using hydrogen fluoride as a model H-bond donor. Under this situation, the stabilization energy of the carbaryl molecule would permit it to adopt a planar conformation. These results are in accordance with the mechanism traditionally accepted for AhR activation: Binding of ligands in a planar conformation.

  7. The Canonical Luminous Blue Variable AG Car and Its Neighbor Hen 3-519 are Much Closer than Previously Assumed

    Science.gov (United States)

    Smith, Nathan; Stassun, Keivan G.

    2017-03-01

    The strong mass loss of Luminous Blue Variables (LBVs) is thought to play a critical role in massive-star evolution, but their place in the evolutionary sequence remains debated. A key to understanding their peculiar instability is their high observed luminosities, which often depends on uncertain distances. Here we report direct distances and space motions of four canonical Milky Way LBVs—AG Car, HR Car, HD 168607, and (candidate) Hen 3-519—from the Gaia first data release. Whereas the distances of HR Car and HD 168607 are consistent with previous literature estimates within the considerable uncertainties, Hen 3-519 and AG Car, both at ∼2 kpc, are much closer than the 6–8 kpc distances previously assumed. As a result, Hen 3-519 moves far from the locus of LBVs on the Hertzsprung–Russell diagram, making it a much less luminous object. For AG Car, considered a defining example of a classical LBV, its lower luminosity would also move it off the S Dor instability strip. Lower luminosities allow both AG Car and Hen 3-519 to have passed through a previous red supergiant phase, lower the mass estimates for their shell nebulae, and imply that binary evolution is needed to account for their peculiarities. These results may also impact our understanding of LBVs as potential supernova progenitors and their isolated environments. Improved distances will be provided in the Gaia second data release, which will include additional LBVs. AG Car and Hen 3-519 hint that this new information may alter our traditional view of LBVs.

  8. Expression of HSP27, HSP72 and MRP proteins in in vitro co-culture of colon tumour cell spheroids with normal cells after incubation with rhTGF- beta1 and/or CPT-11.

    Science.gov (United States)

    Paduch, Roman; Jakubowicz-Gil, Joanna; Kandefer-Szerszen, Martyna

    2009-12-01

    We studied the expression of inducible heat shock protein (HSP27, HSP72) and multidrug-resistance protein (MRP) in co-cultures of human colon carcinoma cell spheroids obtained from different grades of tumour with normal human colon epithelium, myofibroblast and endothelial cell monolayers. We also measured the influence of recombinant human transforming growth factor beta1 (rhTGF-beta1) and camptothecin (CPT-11), added as single agents or in combination, on the levels of the HSPs, MRP, interleukin (IL)-6 and nitric oxide (NO). An immunoblotting analysis with densitometry showed that rhTGF-beta1 and/or CPT-11 increased HSP27, HSP72 and MRP expression in tumour cells and myofibroblasts, as well as in co-cultures compared with appropriate controls. By contrast, in colonic epithelium, inhibition of HSPs and MRP was comparable with that of the control. In endothelial cells, HSP72 was undetectable. Direct interaction of colon tumour spheroids with normal myofibroblasts caused a significant, tumour-grade dependent increase in IL-6 production. Production of IL-6 was significantly lowered by rhTGF-beta1 and/or CPT-11. Tumour cell spheroids cultivated alone produced larger amounts of NO than normal cells. In co-culture, the level of the radical decreased compared with the sum of NO produced by the monocultures of the two types of cells. rhTGF-beta1 and/or CPT-11 decreased NO production both in tumour and normal cell monocultures and their co-cultures. In conclusion, direct interactions between tumour and normal cells influence the expression of HSP27, HSP72 and MRP, and alter IL-6 and NO production. rhTGF-beta1 and/or CPT-11 may potentate resistance to chemotherapy by increasing HSP and MRP expression but, on the other hand, they may limit tumour cell spread by decreasing the level of some soluble mediators of inflammation (IL-6 and NO).

  9. Brain Delivery of Drug and MRI Contrast Agent: Detection and Quantitative Determination of Brain Deposition of CPT-Glu Using LC-MS/MS and Gd-DTPA Using Magnetic Resonance Imaging

    Science.gov (United States)

    Tabanor, Kayann; Lee, Phil; Kiptoo, Paul; Choi, In-Young; Sherry, Erica B.; Eagle, Cheyenne Sun; Williams, Todd D.; Siahaan, Teruna J.

    2015-01-01

    Successful treatment and diagnosis of neurological diseases depend on reliable delivery of molecules across the blood-brain barrier (BBB), which restricts penetration of pharmaceutical drugs and diagnostic agents into the brain. Thus, developing new non-invasive strategies to improve drug delivery across the BBB is critically needed. This study was aimed at evaluating the activity of HAV6 peptide (Ac-SHAVSS-NH2) in improving brain delivery of camptothecin-glutamate (CPT-Glu) conjugate and gadolinium-diethylenetriaminepentaacetate (Gd-DTPA) contrast agent in Sprague-Dawley rats. Brain delivery of both CPT-Glu and Gd-DTPA was evaluated in an in situ rat brain perfusion model in the presence and absence of HAV6 peptide (1.0 mM). Gd-DTPA (0.6 mmol/kg) was intravenously (i.v.) administered with and without HAV6 peptide (0.019 mmol/kg) in rats. The detection and quantification of CPT-Glu and Gd-DTPA in the brain were carried out by LC-MS/MS and quantitative magnetic resonance imaging (MRI), respectively. Rats perfused with CPT-Glu in combination with HAV6 had significantly higher deposition of drug in the brain compared to CPT-Glu alone. MRI results also showed that administration of Gd-DTPA in the presence of HAV6 peptide led to significant accumulation of Gd-DTPA in various regions of the brain in both the in situ rat brain perfusion and in vivo studies. All observations taken together indicate that HAV6 peptide can disrupt the BBB and enhance delivery of small molecules into the brain. PMID:26705088

  10. Expression of HSP27, HSP72 and MRP proteins in in vitro co-culture of colon tumour cell spheroids with normal cells after incubation with rhTGF-1 and/or CPT-11

    Indian Academy of Sciences (India)

    Roman Paduch; Joanna Jakubowicz-Gil; Martyna Kandefer-Szerszeń

    2009-12-01

    We studied the expression of inducible heat shock protein (HSP27, HSP72) and multidrug-resistance protein (MRP) in co-cultures of human colon carcinoma cell spheroids obtained from different grades of tumour with normal human colon epithelium, myofibroblast and endothelial cell monolayers. We also measured the influence of recombinant human transforming growth factor 1 (rhTGF-1) and camptothecin (CPT-11), added as single agents or in combination, on the levels of the HSPs, MRP, interleukin (IL)-6 and nitric oxide (NO). An immunoblotting analysis with densitometry showed that rhTGF-1 and/or CPT-11 increased HSP27, HSP72 and MRP expression in tumour cells and myofibroblasts, as well as in co-cultures compared with appropriate controls. By contrast, in colonic epithelium, inhibition of HSPs and MRP was comparable with that of the control. In endothelial cells, HSP72 was undetectable. Direct interaction of colon tumour spheroids with normal myofibroblasts caused a significant, tumour-grade dependent increase in IL-6 production. Production of IL-6 was significantly lowered by rhTGF-1 and/or CPT-11. Tumour cell spheroids cultivated alone produced larger amounts of NO than normal cells. In co-culture, the level of the radical decreased compared with the sum of NO produced by the monocultures of the two types of cells. rhTGF-1 and/or CPT-11 decreased NO production both in tumour and normal cell monocultures and their co-cultures. In conclusion, direct interactions between tumour and normal cells influence the expression of HSP27, HSP72 and MRP, and alter IL-6 and NO production. rhTGF-1 and/or CPT-11 may potentate resistance to chemotherapy by increasing HSP and MRP expression but, on the other hand, they may limit tumour cell spread by decreasing the level of some soluble mediators of inflammation (IL-6 and NO).

  11. Effects of an assumed cosmic ray-modulated low global cloud cover on the Earth's temperature

    Energy Technology Data Exchange (ETDEWEB)

    Ramirez, J.; Mendoza, B. [Instituto de Geofisica, Universidad Nacional Autonoma de Mexico, Mexico, D.F. (Mexico); Mendoza, V.; Adem, J. [Centro de Ciencias de la Atmosfera, Universidad Nacional Autonoma de Mexico, Mexico, D.F. (Mexico)]. E-mail: victor@atmosfera.unam.mx

    2006-07-15

    We have used the Thermodynamic Model of the Climate to estimate the effect of variations in the low cloud cover on the surface temperature of the Earth in the Northern Hemisphere during the period 1984-1994. We assume that the variations in the low cloud cover are proportional to the variation of the cosmic ray flux measured during the same period. The results indicate that the effect in the surface temperature is more significant in the continents, where for July of 1991, we have found anomalies of the order of 0.7 degrees Celsius for the southeastern of Asia and 0.5 degrees Celsius for the northeast of Mexico. For an increase of 0.75% in the low cloud cover, the surface temperature computed by the model in the North Hemisphere presents a decrease of {approx} 0.11 degrees Celsius; however, for a decrease of 0.90% in the low cloud cover, the model gives an increase in the surface temperature of {approx} 0.15 degrees Celsius, these two cases correspond to a climate sensitivity factor for the case of forcing by duplication of atmospheric CO{sub 2}. These decreases or increases in surface temperature by increases of decreases in low clouds cover are ten times greater than the overall variability of the non-forced model time series. [Spanish] Hemos usado el Modelo Termodinamico del Clima para estimar el efecto de variaciones en la cubierta de nubes bajas sobre la temperatura superficial de la Tierra en el Hemisferio Norte durante el periodo 1984 - 1994. Suponemos que las variaciones en la cubierta de nubes bajas son proporcionales a las variaciones del flujo de rayos cosmicos medido durante el mismo periodo. Los resultados indican que el efecto en la temperatura es mas significativo en los continentes, donde para julio de 1991, hemos encontrado anomalias del orden de 0.7 grados Celsius sobre el sureste de Asia y 0.5 grados Celsius al noreste de Mexico. Para un incremento de 0.75% en la cubierta de nubes bajas, la temperatura de la superficie calculada por el modelo en

  12. Application of 2D electrical resistivity imaging and cone penetration test (CPT) to assess the harzadous effect of near surface water on foundations in Lagos Nigeria

    Science.gov (United States)

    Adewoyin, O. O.; Joshua, E. O.; Akinyemi, M. L.; Omeje, M.; Joel, E. S.

    2017-05-01

    Adequate information on the condition of the subsurface is very important for site evaluation for engineering purposes. In this study two dimensional (2D) geoelectrical resistivity survey and cone penetration tests were conducted to study the hazardous effect of excess near surface water on the foundation of building in a reclaimed land located at Victoria Island area of Lagos State. The results of the inverted 2D geoelectrical resistivity data revealed three distinct geoelectrical layers characterized by low to moderate electrical resistivity of 2.23 and 129Ωm and 9.46 to 636Ωm respectively. The topsoil is characterized by wet sandy soil, which is underlain by sandy clay and banded at the below by a geologic formation of low resistivity which is suspected to be clay. The clay material may be responsible for the excess water retention observed in the area. The CPT method on the other hand revealed a geological formation of low resistance to penetration between 2-3 kg/cm2 from the topsoil to a depth of 7 m, which may be the effect of excess water in the near surface. This study revealed that the foundation of building may not be founded directly on the soil in any reclaimed land as this may result in collapse as a result of upward migration of water to the near surface.

  13. Systematic CpT (ApG depletion and CpG excess are unique genomic signatures of large DNA viruses infecting invertebrates.

    Directory of Open Access Journals (Sweden)

    Mohita Upadhyay

    Full Text Available Differences in the relative abundance of dinucleotides, if any may provide important clues on host-driven evolution of viruses. We studied dinucleotide frequencies of large DNA viruses infecting vertebrates (n = 105; viruses infecting mammals = 99; viruses infecting aves = 6; viruses infecting reptiles = 1 and invertebrates (n = 88; viruses infecting insects = 84; viruses infecting crustaceans = 4. We have identified systematic depletion of CpT(ApG dinucleotides and over-representation of CpG dinucleotides as the unique genomic signature of large DNA viruses infecting invertebrates. Detailed investigation of this unique genomic signature suggests the existence of invertebrate host-induced pressures specifically targeting CpT(ApG and CpG dinucleotides. The depletion of CpT dinucleotides among large DNA viruses infecting invertebrates is at least in part, explained by non-canonical DNA methylation by the infected host. Our findings highlight the role of invertebrate host-related factors in shaping virus evolution and they also provide the necessary framework for future studies on evolution, epigenetics and molecular biology of viruses infecting this group of hosts.

  14. Comparison of 2015 Medicare relative value units for gender-specific procedures: Gynecologic and gynecologic-oncologic versus urologic CPT coding. Has time healed gender-worth?

    Science.gov (United States)

    Benoit, M F; Ma, J F; Upperman, B A

    2017-02-01

    In 1992, Congress implemented a relative value unit (RVU) payment system to set reimbursement for all procedures covered by Medicare. In 1997, data supported that a significant gender bias existed in reimbursement for gynecologic compared to urologic procedures. The present study was performed to compare work and total RVU's for gender specific procedures effective January 2015 and to evaluate if time has healed the gender-based RVU worth. Using the 2015 CPT codes, we compared work and total RVU's for 50 pairs of gender specific procedures. We also evaluated 2015 procedure related provider compensation. The groups were matched so that the procedures were anatomically similar. We also compared 2015 to 1997 RVU and fee schedules. Evaluation of work RVU's for the paired procedures revealed that in 36 cases (72%), male vs female procedures had a higher wRVU and tRVU. For total fee/reimbursement, 42 (84%) male based procedures were compensated at a higher rate than the paired female procedures. On average, male specific surgeries were reimbursed at an amount that was 27.67% higher for male procedures than for female-specific surgeries. Female procedure based work RVU's have increased minimally from 1997 to 2015. Time and effort have trended towards resolution of some gender-related procedure worth discrepancies but there are still significant RVU and compensation differences that should be further reviewed and modified as surgical time and effort highly correlate. Copyright © 2016. Published by Elsevier Inc.

  15. Limits on the Decay-Rate Difference of Neutral B Mesons and on CP, T, and CPT Violation in B0-B0bar Oscillations

    CERN Document Server

    Aubert, Bernard; Boutigny, D; Gaillard, J M; Hicheur, A; Karyotakis, Yu; Lees, J P; Robbe, P; Tisserand, V; Zghiche, A; Palano, A; Pompili, A; Chen, J C; Qi, N D; Rong, G; Wang, P; Zhu, Y S; Eigen, G; Ofte, I; Stugu, B; Abrams, G S; Borgland, A W; Breon, A B; Brown, D N; Button-Shafer, J; Cahn, R N; Charles, E; Day, C T; Gill, M S; Gritsan, A V; Groysman, Y; Jacobsen, R G; Kadel, R W; Kadyk, J; Kerth, L T; Kolomensky, Yu G; Kral, J F; Kukartsev, G; Le Clerc, C; Levi, M E; Lynch, G; Mir, L M; Oddone, P J; Orimoto, T J; Pripstein, M; Roe, N A; Romosan, A; Ronan, Michael T; Shelkov, V G; Telnov, A V; Wenzel, W A; Ford, K; Harrison, T J; Hawkes, C M; Knowles, D J; Morgan, S E; Penny, R C; Watson, A T; Watson, N K; Deppermann, T; Goetzen, K; Koch, H; Lewandowski, B; Pelizaeus, M; Peters, K; Schmücker, H; Steinke, M; Barlow, N R; Boyd, J T; Chevalier, N; Cottingham, W N; Kelly, M P; Latham, T E; MacKay, C; Wilson, F F; Abe, K; Çuhadar-Dönszelmann, T; Hearty, C; Mattison, T S; McKenna, J A; Thiessen, D; Kyberd, P; McKemey, A K; Blinov, V E; Bukin, A D; Golubev, V B; Ivanchenko, V N; Kravchenko, E A; Onuchin, A P; Serednyakov, S I; Skovpen, Yu I; Solodov, E P; Yushkov, A N; Best, D; Bruinsma, M; Chao, M; Kirkby, D; Lankford, A J; Mandelkern, M A; Mommsen, R K; Röthel, W; Stoker, D P; Buchanan, C; Hartfiel, B L; Shen, B C; Del Re, D; Hadavand, H K; Hill, E J; MacFarlane, D B; Paar, H P; Rahatlou, S; Schwanke, U; Sharma, V; Berryhill, J W; Campagnari, C; Dahmes, B; Kuznetsova, N; Levy, S L; Long, O; Lu, A; Mazur, M A; Richman, J D; Verkerke, W; Beck, T W; Beringer, J; Eisner, A M; Heusch, C A; Lockman, W S; Schalk, T; Schmitz, R E; Schumm, B A; Seiden, A; Turri, M; Walkowiak, W; Williams, D C; Wilson, M G; Albert, J; Chen, E; Dubois-Felsmann, G P; Dvoretskii, A; Hitlin, D G; Narsky, I; Porter, F C; Ryd, A; Samuel, A; Yang, S; Jayatilleke, S M; Mancinelli, G; Meadows, B T; Sokoloff, M D; Abe, T; Blanc, F; Bloom, P; Chen, S; Clark, P J; Ford, W T; Nauenberg, U; Olivas, A; Rankin, P; Roy, J; Smith, J G; Van Hoek, W C; Zhang, L; Harton, J L; Hu, T; Soffer, A; Toki, W H; Wilson, R J; Zhang, J; Altenburg, D; Brandt, T; Brose, J; Colberg, T; Dickopp, M; Dubitzky, R S; Hauke, A; Lacker, H M; Maly, E; Müller-Pfefferkorn, R; Nogowski, R; Otto, S; Schubert, J; Schubert, Klaus R; Schwierz, R; Spaan, B; Wilden, L; Bernard, D; Bonneaud, G R; Brochard, F; Cohen-Tanugi, J; Grenier, P; Thiebaux, C; Vasileiadis, G; Verderi, M; Khan, A; Lavin, D; Muheim, F; Playfer, S; Swain, J E; Tinslay, J; Andreotti, M; Azzolini, V; Bettoni, D; Bozzi, C; Calabrese, R; Cibinetto, G; Luppi, E; Negrini, M; Piemontese, L; Sarti, A; Treadwell, E; Anulli, F; Baldini-Ferroli, R; Biasini, M; Calcaterra, A; De Sangro, R; Falciai, D; Finocchiaro, G; Patteri, P; Peruzzi, I M; Piccolo, M; Pioppi, M; Zallo, A; Buzzo, A; Capra, R; Contri, R; Crosetti, G; Lo Vetere, M; Macri, M; Monge, M R; Passaggio, S; Patrignani, C; Robutti, E; Santroni, A; Tosi, S; Bailey, S; Morii, M; Won, E; Bhimji, W; Bowerman, D A; Dauncey, P D; Egede, U; Eschrich, I; Gaillard, J R; Morton, G W; Nash, J A; Sanders, P; Taylor, G P; Grenier, G J; Lee, S J; Mallik, U; Cochran, J; Crawley, H B; Lamsa, J; Meyer, W T; Prell, S; Rosenberg, E I; Yi, J; Davier, M; Grosdidier, G; Höcker, A; Laplace, S; Le Diberder, F R; Lepeltier, V; Lutz, A M; Petersen, T C; Plaszczynski, S; Schune, M H; Tantot, L; Wormser, G; Brigljevic, V; Cheng, C H; Lange, D J; Wright, D M; Bevan, A J; Coleman, J P; Fry, J R; Gabathuler, Erwin; Gamet, R; Kay, M; Parry, R J; Payne, D J; Sloane, R J; Touramanis, C; Back, J J; Harrison, P F; Shorthouse, H W; Strother, P; Vidal, P B; Brown, C L; Cowan, G; Flack, R L; Flächer, H U; George, S; Green, M G; Kurup, A; Marker, C E; McMahon, T R; Ricciardi, S; Salvatore, F; Vaitsas, G; Winter, M A; Brown, D; Davis, C L; Allison, J; Barlow, R J; Forti, A C; Hart, P A; Jackson, F; Lafferty, G D; Lyon, A J; Weatherall, J H; Williams, J C; Farbin, A; Jawahery, A; Kovalskyi, D; Lae, C K; Lillard, V; Roberts, D A; Blaylock, G; Dallapiccola, C; Flood, K T; Hertzbach, S S; Kofler, R; Koptchev, V B; Moore, T B; Saremi, S; Stängle, H; Willocq, S; Cowan, R; Sciolla, G; Taylor, F; Yamamoto, R K; Mangeol, D J J; Milek, M; Patel, P M; Lazzaro, A; Palombo, F; Bauer, J M; Cremaldi, L M; Eschenburg, V; Godang, R; Kroeger, R; Reidy, J; Sanders, D A; Summers, D J; Zhao, H W; Brunet, S; Cote-Ahern, D; Hast, C; Taras, P; Nicholson, H; Cartaro, C; Cavallo, N; De Nardo, Gallieno; Fabozzi, F; Gatto, C; Lista, L; Paolucci, P; Piccolo, D; Sciacca, C; Baak, M A; Raven, G; LoSecco, J M; Gabriel, T A; Brau, B; Gan, K K; Honscheid, K; Hufnagel, D; Kagan, H; Kass, R; Pulliam, T; Wong, Q K; Brau, J E; Frey, R; Potter, C T; Sinev, N B; Strom, D; Torrence, E; Colecchia, F; Dorigo, A; Galeazzi, F; Margoni, M; Morandin, M; Posocco, M; Rotondo, M; Simonetto, F; Stroili, R; Tiozzo, G; Voci, C; Benayoun, M; Briand, H; Chauveau, J; David, P; La Vaissière, C de; Del Buono, L; Hamon, O; John, M J J; Leruste, P; Ocariz, J; Pivk, M; Roos, L; Stark, J; T'Jampens, S; Therin, G; Manfredi, P F; Re, V; Behera, P K; Gladney, L; Guo, Q H; Panetta, J; Angelini, C; Batignani, G; Bettarini, S; Bondioli, M; Bucci, F; Calderini, G; Carpinelli, M; Forti, F; Giorgi, M A; Lusiani, A; Marchiori, G; Martínez-Vidal, F; Morganti, M; Neri, N; Paoloni, E; Rama, M; Rizzo, G; Sandrelli, F; Walsh, J; Haire, M; Judd, D; Paick, K; Wagoner, D E; Danielson, N; Elmer, P; Lü, C; Miftakov, V; Olsen, J; Smith, A J S; Tanaka, H A; Varnes, E W; Bellini, F; Cavoto, G; Faccini, R; Ferrarotto, F; Ferroni, F; Gaspero, M; Mazzoni, M A; Morganti, S; Pierini, M; Piredda, G; Safai-Tehrani, F; Voena, C; Christ, S; Wagner, G; Waldi, R; Adye, T; De Groot, N; Franek, B J; Geddes, N I; Gopal, G P; Olaiya, E O; Xella, S M; Aleksan, Roy; Emery, S; Gaidot, A; Ganzhur, S F; Giraud, P F; Hamel de Monchenault, G; Monchenault; Kozanecki, Witold; Langer, M; Legendre, M; London, G W; Mayer, B; Schott, G; Vasseur, G; Yéche, C; Zito, M; Purohit, M V; Weidemann, A W; Yumiceva, F X; Aston, D; Bartoldus, R; Berger, N; Boyarski, A M; Buchmüller, O L; Convery, M R; Coupal, D P; Dong, D; Dorfan, J; Dujmic, D; Dunwoodie, W M; Field, R C; Glanzman, T; Gowdy, S J; Graugès-Pous, E; Hadig, T; Halyo, V; Hrynóva, T; Innes, W R; Jessop, C P; Kelsey, M H; Kim, P; Kocian, M L; Langenegger, U; Leith, D W G S; Luitz, S; Lüth, V; Lynch, H L; Marsiske, H; Messner, R; Müller, D R; O'Grady, C P; Ozcan, V E; Perazzo, A; Perl, M; Petrak, S; Ratcliff, B N; Robertson, S H; Roodman, A; Salnikov, A A; Schindler, R H; Schwiening, J; Simi, G; Snyder, A; Soha, A; Stelzer, J; Su, D; Sullivan, M K; Vavra, J; Wagner, S R; Weaver, M; Weinstein, A J R; Wisniewski, W J; Wright, D H; Young, C C; Burchat, Patricia R; Edwards, A J; Meyer, T I; Petersen, B A; Roat, C; Ahmed, S; Alam, M S; Ernst, J A; Saleem, M; Wappler, F R; Bugg, W; Krishnamurthy, M; Spanier, S M; Eckmann, R; Kim, H; Ritchie, J L; Schwitters, R F; Izen, J M; Kitayama, I; Lou, X C; Ye, S; Bianchi, F; Bóna, M; Gallo, F; Gamba, D; Borean, C; Bosisio, L; Della Ricca, G; Dittongo, S; Grancagnolo, S; Lanceri, L; Poropat, P; Vitale, L; Vuagnin, G; Panvini, R S; Banerjee, Sw; Brown, C M; Fortin, D; Jackson, P D; Kowalewski, R V; Roney, J M; Band, H R; Dasu, S; Datta, M; Eichenbaum, A M; Johnson, J R; Kutter, P E; Li, H; Liu, R; Di Lodovico, F; Mihályi, A; Mohapatra, A K; Pan, Y; Prepost, R; Sekula, S J; Von Wimmersperg-Töller, J H; Wu, J; Wu Sau Lan; Yu, Z; Neal, H

    2003-01-01

    Using events in which one of two neutral B mesons from the decay of an Y(4S) meson is fully reconstructed, we determine parameters governing decay (\\Delta\\Gamma_d/\\Gamma_d), CP and T violation (|q/p|), and CP and CPT violation (Rez,Imz). The results, obtained from an analysis of 88 million Y(4S) decays recorded by BABAR, are -- sgn(Re(lambdaCP))\\Delta\\Gamma_d/Gamma_d = -0.008 +- 0.037 +- 0.018 [ -0.084, 0.068 ] |q/p| = 1.029 +- 0.013 +- 0.011 [ 1.001, 1.057 ] Re(lambdaCP)/|lambdaCP| Rez = 0.014 +- 0.035 +- 0.034 [ -0.072, 0.101 ] Imz = 0.038 +- 0.029 +- 0.025 [ -0.028, 0.104 ]. -- The values inside square brackets indicate the 90% confidence-level intervals. These results are consistent with Standard Model expectations.

  16. 视听整合持续测试的诊断价值%Value of Diagnosis on IVA——CPT.

    Institute of Scientific and Technical Information of China (English)

    张姝

    2009-01-01

    目的 探讨视听整合持续潮试(IVA-CPT)在儿童注意缺陷多动障碍(attention deficit hyperactivity disorder ADHD)辅助诊断中的评估价值.方法 应用IVA-CPT操作评估软件对一组符合DSM--Ⅳ诊断标准的多动症儿童和一些正常儿童进行洲试.结果 根据DSM--Ⅳ诊断标准,76例ADHD患儿经IVA-CPT测试,结果 异常,符合临床诊断的有69例,敏感度为90.79%;40例正常儿童中结果 有异常的5例,特异度为87.5%;假阴性率为9.11%;假阳性率为12.5%.结论 IVA--CPT是客观、标准、高精确度的持续性操作测试,在ADHD诊断中有较理想的辅助诊断意义,值得推广应用.

  17. Working memory updating occurs independently of the need to maintain task-context: accounting for triggering updating in the AX-CPT paradigm.

    Science.gov (United States)

    Kessler, Yoav; Baruchin, Liad J; Bouhsira-Sabag, Anat

    2017-01-01

    Theoretical models suggest that maintenance and updating are two functional states of working memory (WM), which are controlled by a gate between perceptual information and WM representations. Opening the gate enables updating WM with input, while closing it enables keeping the maintained information shielded from interference. However, it is still unclear when gate opening takes place, and what is the external signal that triggers it. A version of the AX-CPT paradigm was used to examine a recent proposal in the literature, suggesting that updating is triggered whenever the maintenance of the context is necessary for task performance (context-dependent tasks). In four experiments using this paradigm, we show that (1) a task-switching cost takes place in both context-dependent and context-independent trials; (2) task-switching is additive to the dependency effect, and (3) unlike switching cost, the dependency effect is not affected by preparation and, therefore, does not reflect context-updating. We suggest that WM updating is likely to be triggered by a simple mechanism that occurs in each trial of the task regardless of whether maintaining the context is needed or not. The implications for WM updating and its relationship to task-switching are discussed.

  18. New limit on Lorentz and CPT violating neutron spin interactions using a free precession 3He-129Xe co-magnetometer

    CERN Document Server

    Allmendinger, F; Karpuk, S; Kilian, W; Scharth, A; Schmidt, U; Schnabel, A; Sobolev, Yu; Tullney, K

    2013-01-01

    We report on the search for a CPT and Lorentz invariance violating coupling of the 3He and 129Xe nuclear spins (each largely determined by a valence neutron) to background tensor fields which permeate the universe. Our experimental approach is to measure the free precession of nuclear spin polarized 3He and 129Xe atoms in a homogeneous magnetic guiding field of about 400 nT using LTC SQUIDs as low-noise magnetic flux detectors. As the laboratory reference frame rotates with respect to distant stars, we look for a sidereal modulation of the Larmor frequencies of the co-located spin samples. As a result we obtain an upper limit on the equatorial component of the background field interacting with the spin of the bound neutron bn< 6.7*10^-34 GeV (68% C.L.). Our result improves our previous limit (data measured in 2009) by a factor of 30 and the world's best limit by a factor of 5.

  19. Assessment on attention deficiency for anxiety patients by IVA-CPT%视听整合连续执行测试对焦虑症患者注意力障碍的评价

    Institute of Scientific and Technical Information of China (English)

    母代斌; 阿丽童·苏来曼; 张萍; 阿斯古丽·沙依提

    2012-01-01

    目的 探讨视听整合连续执行测试(integrated visual and auditory continuous performance test,IVA-CPT)在焦虑症患者治疗前后的注意缺陷特征及改善情况中的价值.方法 对56例住院焦虑症患者(研究组)及40例正常健康者(对照组)进行视听整合连续执行测试(IVA-CPT),采用PEMS 3.1软件对常用的12个商数数据进行统计分析.结果 (1)治疗前,研究组患者IVA-CPT 12个商数中9个低于对照组,差异有统计学意义(P<0.05).(2)治疗后,研究组患者IVA-CPT 12个商数中有9个升高,与治疗前相比差异有统计学意义(P<0.05).(3)治疗前IVA-CPT大部分商数与汉密尔顿焦虑量表(HAMA)分值呈负性相关趋势.结论 焦虑症患者存在注意力缺陷,经过治疗可以得到改善.IVA-CPT对焦虑症患者注意功能缺陷有较好的、客观的辅助评估价值.

  20. Utility of Genetic Testing for Confirmation of Abnormal Newborn Screening in Disorders of Long-Chain Fatty Acids: A Missed Case of Carnitine Palmitoyltransferase 1A (CPT1A) Deficiency

    OpenAIRE

    Dowsett, Leah; Lulis, Lauren; Ficicioglu, Can; Cuddapah, Sanmati

    2017-01-01

    An 18-month-old male was evaluated after presenting with disproportionately elevated liver transaminases in the setting of acute gastroenteritis. He had marked hepatomegaly on physical exam that was later confirmed with an abdominal ultrasound. Given this clinical picture, suspicion for a fatty acid oxidation disorder was raised. Further investigation revealed that his initial newborn screen was positive for carnitine palmitoyltransferase 1A (CPT1A) deficiency?a rare autosomal recessive disor...

  1. Search For Cpt Violation With The Focus Experiment And Measurement Of Lambda(b) Lifetime In The Decay Lambda(b) Decaying To J/psi Lambda With The Do Experiment

    CERN Document Server

    Kryemadhi, A

    2004-01-01

    This dissertation describes two different projects from two different experiments. We have performed a search for CPT violation in neutral charm meson oscillations using data from the FOCUS Experiment. While flavor mixing in the charm sector is predicted to be small in the Standard Model, it is still possible to investigate CPT violation through a study of the proper time dependence of a CPT asymmetry in right-sign decay rates for D0 → K−π + and D¯0 → K +π−. We also present measurements of the L0b lifetime in the exclusive decay channel L0b → J/ yL with J/ y → μ+μ− and Λ → pπ−, the B0 lifetime in the decay B0d → J/ yK0S with J/ y → μ+μ− and K0S → π+π−, and the ratio of these lifetimes. The analysis is based on approximately 225 pb−1 of data recorded with the D&O...

  2. Impact of the magnetic potential transformer (MPT) substitution by capacitive potential transformers (CPT) on the three phase re closing of the 765 kV lines; Impacto del cambio de los TPM por TPC en el recierre trifasico de las lineas a 765 kV

    Energy Technology Data Exchange (ETDEWEB)

    Carrasco, Gustavo; Tarazona, Javier [C.V.G. Electrification del Caroni, C.A. (EDELCA), Caracas (Venezuela)]. E-mail: gcarrasco@edelca.com.ve

    2001-07-01

    This paper evaluates trough simulations of energization manoeuvres and three phase reclosing (TPR), the impact of replacing the magnetic potential transformers (MPT) by capacitive potential transformers (CPT) on the 765 kV lines of the Venezuelan transmission system from the viewpoint of overvoltage. The obtained results allows the conclusion that the replacement of CPT by MPT transformers does not represents a restriction for the implementation of the three phase scheme in the 765 kV system.

  3. CQ synergistically sensitizes human colorectal cancer cells to SN-38/CPT-11 through lysosomal and mitochondrial apoptotic pathway via p53-ROS cross-talk.

    Science.gov (United States)

    Chen, Pinjia; Luo, Xiaoyong; Nie, Peipei; Wu, Baoyan; Xu, Wei; Shi, Xinpeng; Chang, Haocai; Li, Bing; Yu, Xiurong; Zou, Zhengzhi

    2017-03-01

    Autophagy plays a key role in supporting cell survival against chemotherapy-induced apoptosis. In this study, we found the chemotherapy agent SN-38 induced autophagy in colorectal cancer (CRC) cells. However, inhibition of autophagy using a small molecular inhibitor 3-methyladenine (3-MA) and ATG5 siRNA did not increase SN-38-induced cytotoxicity in CRC cells. Notably, another autophagy inhibitor chloroquine (CQ) synergistically enhanced the anti-tumor activity of SN-38 in CRC cells with wild type (WT) p53. Subsequently, we identified a potential mechanism of this cooperative interaction by showing that CQ and SN-38 acted together to trigger reactive oxygen species (ROS) burst, upregulate p53 expression, elicit the loss of lysosomal membrane potential (LMP) and mitochondrial membrane potential (∆ψm). In addition, ROS induced by CQ plus SN-38 upregulated p53 levels by activating p38, conversely, p53 stimulated ROS. These results suggested that ROS and p53 reciprocally promoted each other's production and cooperated to induce CRC cell death. Moreover, we showed induction of ROS and p53 by the two agents provoked the loss of LMP and ∆ψm. Altogether, all results suggested that CQ synergistically sensitized human CRC cells with WT p53 to SN-38 through lysosomal and mitochondrial apoptotic pathway via p53-ROS cross-talk. Lastly, we showed that CQ could enhance CRC cells response to CPT-11 (a prodrug of SN-38) in xenograft models. Thus the combined treatment might represent an attractive therapeutic strategy for the treatment of CRC.

  4. A Search for Lorentz and CPT Violation in the Neutrino Sector of the Standard Model Extension Using the Near Detectors of the Tokai to Kamioka Neutrino Oscillation Experiment

    Science.gov (United States)

    Clifton, Gary Alexander

    The Tokai to Kamioka (T2K) neutrino experiment is designed to search for electron neutrino appearance oscillations and muon neutrino disappearance oscillations. While the main physics goals of T2K fall into conventional physics, T2K may be used to search for more exotic physics. One exotic physics analysis that can be performed is a search for Lorentz and CPT symmetry violation (LV and CPTV) through short baseline neutrino oscillations. The theoretical framework which describes these phenomena is the Standard Model Extension (SME). Due to its off-axis nature, T2K has two near detectors. A search for LV and CPTV is performed in each detector. The search utilizes charged-current inclusive (CC inclusive) neutrino events to search for sidereal variations in the neutrino event rate at each detector. Two methods are developed; the first being a Fast Fourier Transform method to perform a hypothesis test of the data with a set of 10,000 toy Monte-Carlo simulations that do not have any LV signal in them. The second is a binned likelihood fit. Using three data sets, both analysis methods are consistent with no sidereal variations. One set of data is used to calculate upper limits on combinations of the SME coefficients while the other two are used to constrain the SME coefficients directly. Despite not seeing any indication of LV in the T2K near detectors, the upper limits provided are useful for the theoretical field to continue improving theories which include LV and CPTV.

  5. Common aspects and differences in the behaviour of classical configuration versus canard configuration aircraft in the presence of vertical gusts, assuming the hypothesis of an elastic fuselage

    Directory of Open Access Journals (Sweden)

    Octavian PREOTU

    2011-06-01

    Full Text Available The paper analyzes, in parallel, common aspects and differences in the behavior of classical configuration versus canard configuration aircraft in the presence of vertical gusts, assuming the hypothesis of an elastic fuselage. The effects of the main constructional dimensions of the horizontal empennage on lift cancelling and horizontal empennage control are being analyzed

  6. Assumed white blood cell count of 8,000 cells/μL overestimates malaria parasite density in the Brazilian Amazon.

    Directory of Open Access Journals (Sweden)

    Eduardo R Alves-Junior

    Full Text Available Quantification of parasite density is an important component in the diagnosis of malaria infection. The accuracy of this estimation varies according to the method used. The aim of this study was to assess the agreement between the parasite density values obtained with the assumed value of 8,000 cells/μL and the automated WBC count. Moreover, the same comparative analysis was carried out for other assumed values of WBCs. The study was carried out in Brazil with 403 malaria patients who were infected in different endemic areas of the Brazilian Amazon. The use of a fixed WBC count of 8,000 cells/μL to quantify parasite density in malaria patients led to overestimated parasitemia and resulted in low reliability when compared to the automated WBC count. Assumed values ranging between 5,000 and 6,000 cells/μL, and 5,500 cells/μL in particular, showed higher reliability and more similar values of parasite density when compared between the 2 methods. The findings show that assumed WBC count of 5,500 cells/μL could lead to a more accurate estimation of parasite density for malaria patients in this endemic region.

  7. Father time; 2, A physical basis behind Feynman's idea of antiparticles moving backward in time, and an extension of the CPT theorem to include non-local gauge fields

    CERN Document Server

    Rai-Dastidar, T K; Dastidar, Krishna Rai

    1999-01-01

    It has been demonstrated in a recent paper (Mod.Phys.Lett. A13, 1265 (1998); hep-th/9902020) that the existence of a non-thermodynamic arrow of time at the atomic level is a fundamental requirement for conservation of energy in matter-radiation interaction. Since the universe consists of two things only --- energy and massive matter --- we argue that as a consequence of this earlier result, particles and antiparticles must necessarily move in opposite directions in time. Our result further indicates that the CPT theorem can be extended to cover non-local gauge fields.

  8. 河南省高校可承担债务比例分析%AN ANALYSIS OF THE RATIO OF DEBT UNIVERSITIES CAN ASSUME IN HENAN PROVINCE

    Institute of Scientific and Technical Information of China (English)

    任新平

    2012-01-01

    以高校债务与收入资料为基础,对当前高校可承担债务比例与风险状况进行了测算,揭示出还款期限与还款比例之间的关系。%The paper measures and calculates the ratio of debt universities can assume at present and the current condition of risks based on their debt and revenue and then it reveals the relationship between reimbursement deadline and ratio.

  9. Influence of DMBA-induced mammary cancer on the liver CPT I, mit HMG-CoA synthase and PPARalpha mRNA expression in rats fed a low or high corn oil diet.

    Science.gov (United States)

    Moral, Raquel; Solanas, Montserrat; Manzanares, Eva Mónica; Haro, Diego; Escrich, Eduard

    2004-08-01

    Hepatic mitochondrial outer membrane carnitine palmitoyltransferase I (CPT I) and mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase (HMG-CoA synthase) enzymes play a key role in regulation of fatty acid oxidation and in ketogenic pathways, respectively. Their expression are regulated by fatty acids mainly by the peroxisome proliferator-activated receptor alpha (PPARalpha). To investigate possible mechanisms through which cancer alters the lipid metabolism, we analyzed by Northern blot, the mRNA relative abundance of these proteins in liver from healthy and DMBA-induced mammary tumor-bearing rats fed a low or high corn oil diet. Serum levels of lipids, body weight and mass were also determined. Whereas mRNA steady-state levels of CPT I and mit HMG-CoA synthase were unaffected by the presence of the extra-hepatic tumor, the cancer state seemed to modify the regulation of the expression of these genes by high fat diet. We hypothesize that putative changes in PPARalpha mRNA levels could have contributed to such alterations. These results, together with changes in serum lipid profiles, body weight and mass, indicate fat mobilization and non-enhanced oxidation rates despite a high-fat feeding. This effect of the cancer state could be related to tumor aggressiveness and suggest a preferential redirection of long-chain fatty acids into energetic and specific pathways of the cancer cells.

  10. A novel membrane-bound toxin for cell division, CptA (YgfX), inhibits polymerization of cytoskeleton proteins, FtsZ and MreB, in Escherichia coli.

    Science.gov (United States)

    Masuda, Hisako; Tan, Qian; Awano, Naoki; Yamaguchi, Yoshihiro; Inouye, Masayori

    2012-03-01

    Nearly all free-living bacteria carry toxin-antitoxin (TA) systems on their genomes, through which cell growth and death are regulated. Toxins target a variety of essential cellular functions, including DNA replication, translation, and cell division. Here, we identified a novel toxin, YgfX, on the Escherichia coli genome. The toxin, consisting of 135 residues, is composed of the N-terminal membrane domain, which encompasses two transmembrane segments, and the C-terminal cytoplasmic domain. Upon YgfX expression, the cells were initially elongated and then the middle portion of the cells became inflated to form a lemon shape. YgfX was found to interact with MreB and FtsZ, two essential cytoskeletal proteins in E. coli. The cytoplasmic domain [YgfX(C)] was found to be responsible for the YgfX toxicity, as purified YgfX(C) was found to block the polymerization of FtsZ and MreB in vitro. YgfY, located immediately upstream of YgfX, was shown to be the cognate antitoxin; notably, YgfX is the first membrane-associating toxin in bacterial TA systems. We propose to rename the toxin and the antitoxin as CptA and CptB (for Cytoskeleton Polymerization inhibiting Toxin), respectively.

  11. The Originality of Regionalism in Castile and Leon Between 1931 and 1932. A Genuine Proyect or the Need to Assume a Second Best?

    Directory of Open Access Journals (Sweden)

    Luis Felipe PALACIOS

    2016-05-01

    Full Text Available Between 1931 and 1932, as in other regions of Spain, Castile and Leon saw the resurgence of a regionalism that, so far, had hardly shown any signs of vitality. From this point, the question that arises is whether the renewed regionalist activity in Castile and Leon reflected an original feeling or was the consequence of the political advancement in Catalonia and of the new model of territorial organization regulated by the 1931 Constitution. Considering the behavior and the statements of the political, social and institutional forces, we can say that the regionalism in Castile and Leon did not respond to a genuine feeling but it was the result of the necessity of assuming a second best.

  12. Discussion on the Scope of Legal Fictions to Assume Executives and Employees of Entrusted Agencies Are Civil Servants in the Application of Punishments

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Sang-won; Jang, Gun-hyeon; Kim, Chang-beom; Go, Jae-dong; Ahn, Hyeong-jun; Rhyu, Jung; Chung, Sang-ki [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2008-05-15

    Article 122 of the Atomic Energy Act sets forth that 'executives and employees of an agency engaged in an entrusted work or its associated specialized agency, in the application of any punishment as per the Criminal Act or other laws, shall be regarded as civil servants,' stipulating that the scope of legal fictions to assume such persons are civil servants should be applicable to any punishment as per the Criminal Act or other laws. Accordingly, the executives and employees of an entrusted agency or its associated specialized agency are subject to the punishments not only for acceptance of graft but also for dereliction of duty or divulgence of classified information. In addition, they are also subject to increased punishment in accordance with other laws, for example, such special laws as Law Concerning Increased Punishment for Specified Crimes and Law Concerning Increased Punishment for Specified Economic Crimes.

  13. New insight into fat, muscle and bone relationship in women: determining the threshold at which body fat assumes negative relationship with bone mineral density.

    Science.gov (United States)

    Liu, Pei-Yang; Ilich, Jasminka Z; Brummel-Smith, Ken; Ghosh, Sunita

    2014-11-01

    The aim was to investigate the relationships among lean mass (LM), fat mass (FM), and bone mineral density (BMD) in women stratified by body mass index (BMI) (BMI - normal-weight, overweight, obese) and to determine threshold at which body fat assumes negative relationship with BMD. This was a cross-sectional study in 471 healthy Caucasian women, aged 18-67 years. BMD, LM, and FM were measured using dual-energy X-ray absorptiometry. Analysis of variance with Bonferroni corrections was used to test the BMI group differences. Linear regression was used to examine independent contributions of LM and FM on BMD of various skeletal sites (controlling for age and height). In overweight/obese women PROC LOESS plots were used to determine the inflection points at which either LM or FM relationship with BMD changes direction. Separate analyses in pre- and post-menopausal women were conducted as well. Spine and femoral neck BMD were not different among three BMI groups while total body, femur and radius BMD were statistically different (the highest in the obese group). Linear regression revealed that LM had significant positive association with BMD of various skeletal sites in all groups. FM showed a negative association with BMD of femoral neck and femur in normal-weight and spine in overweight women, but a positive association with radius in obese women. Inflection points showed that body fat between 33% and 38% assumed negative relationship with BMD for most skeletal sites in overweight and obese women. Although LM has strong positive relationship with BMD, FM above 33% in overweight/obese women is negatively related to BMD of most skeletal sites. Therefore, overweight/obesity after certain amount of FM, may not be a protective factor against osteoporosis in females. For clinical practice in women, it is important to maintain LM and keep FM accrual below ~30% body fat to maintain good skeletal health.

  14. 基于假设模态法的风力机动力学分析%Dynamic analysis of a wind turbine base on assumed mode method

    Institute of Scientific and Technical Information of China (English)

    王磊; 陈柳; 何玉林; 刘桦; 金鑫

    2012-01-01

    The structural dynamic model of a wind turbine was investigated by using assumed mode method. Veer turbulence model was created for generating time history of three-dimensional wind speed. Along with a wind field model and a modified BEM model, aero-elastic system dynamic model of a wind turbine was constructed with fortran. This model described the dynamics of the wind turbine more correctly than the subsystem model did. A 2.5 MW wind turbine model was calculated and the results were compared with those using GH bladed data. The results showed that the proposed method has excellent capacity to simulate dynamic characteristics of a wind turbine based on the theory of assumed mode method with less computing time and higher accuracy.%采用Kane方法建立风力机系统动力学模型,并使用假设模态离散化方法对其进行柔性化.结合修正的BEM理论计算得到的风轮气动载荷,并在Fortran环境下编程建立风力机整机的系统动力学数学模型,完成对风力机的随机响应分析.以某型2.5MW风力发电机组为研究对象进行分析计算,将分析数据同国际权威计算软件GH Bladed数据比较.比较表明,该分析模型可以较好的模拟风力机的动力学特性,同时兼顾了较少建模计算时间和较高分析精度两个优点,近而验证采用假设模态法进行风力机动力学分析是一种行之有效的方法.

  15. On the analytical solution of the S{sub N} equation in a rectangle assuming an exponential exiting angular flux boundary

    Energy Technology Data Exchange (ETDEWEB)

    Goncalez, Tifani T. [Universidade Federal do Rio Grande do Sul (PROMEC/UFRGS), Porto Alegre, RS (Brazil). Programa de Pos-Graduacao em Engenharia Mecanica; Segatto, Cynthia F.; Vilhena, Marco Tullio, E-mail: csegatto@pq.cnpq.b, E-mail: vilhena@pq.cnpq.b [Universidade Federal do Rio Grande do Sul (DMPA/UFRGS), Porto Alegre, RS (Brazil). Programa de Pos-Graduacao em Matematica Aplicada

    2011-07-01

    In this work, we report an analytical solution for the set of S{sub N} equations for the angular flux, in a rectangle, using the double Laplace transform technique. Its main idea comprehends the steps: application of the Laplace transform in one space variable, solution of the resulting equation by the LTS{sub N} method and reconstruction of the double Laplace transformed angular flux using the inversion theorem of the Laplace transform. We must emphasize that we perform the Laplace inversion by the LTS{sub N} method in the x direction, meanwhile we evaluate the inversion in the y direction performing the calculation of the corresponding line integral solution by the Stefest method. We have also to figure out that the application of Laplace transform to this type of boundary value problem introduces additional unknown functions associated to the partial derivatives of the angular flux at boundary. Based on the good results attained by the nodal LTS{sub N} method, we assume that the angular flux at boundary is also approximated by an exponential function. By analytical we mean that no approximation is done along the solution derivation except for the exponential hypothesis for the exiting angular flux at boundary. For sake of completeness, we report numerical comparisons of the obtained results against the ones of the literature. (author)

  16. Natural beauty of the standard model -A derivation of electro-weak unified and quantum-gravity theory without assuming a Higgs particle-

    CERN Document Server

    Nishikawa, M

    2004-01-01

    We study the asymptotic behavior of a singular potential that arises under several frequently occurring analytic behaviors of the eigenfunctions without introducing cut-offs. Instead, in our analyses we focus on power behaviors of eigenfunctions. Then, we discuss the self-consistency condition for the spherical symmetric Klein-Gordon equation, and discuss a natural possibility that gravity and weak coupling constants $g_G$ and $g_W$ may be defined after $g_{EM}$. In this point of view, gravity and the weak force are subsidiary derived from electricity. Particularly, $SU(2)_L\\times U(1)$ unification is derived without assuming a phase transition. A possible origin of the Higgs mechanism is proposed. Each particle pair of the standard model is associated with the corresponding asymptotic expansion of an eigenfunction. Next we consider the meaning of internal and external degreesof freedom for a two body problem, and find two degrees of freedom which can not reduce to the local motion of one frame. These two deg...

  17. Is it growing exponentially fast? -- Impact of assuming exponential growth for characterizing and forecasting epidemics with initial near-exponential growth dynamics.

    Science.gov (United States)

    Chowell, Gerardo; Viboud, Cécile

    2016-10-01

    The increasing use of mathematical models for epidemic forecasting has highlighted the importance of designing models that capture the baseline transmission characteristics in order to generate reliable epidemic forecasts. Improved models for epidemic forecasting could be achieved by identifying signature features of epidemic growth, which could inform the design of models of disease spread and reveal important characteristics of the transmission process. In particular, it is often taken for granted that the early growth phase of different growth processes in nature follow early exponential growth dynamics. In the context of infectious disease spread, this assumption is often convenient to describe a transmission process with mass action kinetics using differential equations and generate analytic expressions and estimates of the reproduction number. In this article, we carry out a simulation study to illustrate the impact of incorrectly assuming an exponential-growth model to characterize the early phase (e.g., 3-5 disease generation intervals) of an infectious disease outbreak that follows near-exponential growth dynamics. Specifically, we assess the impact on: 1) goodness of fit, 2) bias on the growth parameter, and 3) the impact on short-term epidemic forecasts. Designing transmission models and statistical approaches that more flexibly capture the profile of epidemic growth could lead to enhanced model fit, improved estimates of key transmission parameters, and more realistic epidemic forecasts.

  18. Compensation crisis related to the onsite adequacy evaluation during FNA procedures-Urgent proactive input from cytopathology community is critical to establish appropriate reimbursement for CPT code 88172 (or its new counterpart if introduced in the future

    Directory of Open Access Journals (Sweden)

    Dhillon Inderpreet

    2010-01-01

    Full Text Available The confusion centered around appropriate use of the CPT billing code 88172 is addressed in the commentary from the Economic and Government Affairs Committee of the American Society of Cytopathology (ASC who have written a timely commentary in this issue of Cytojournal, "Adequate Reimbursement is Crucial to Support Cost-Effective Rapid Onsite Cytopathology Evaluations". Currently, lack of standardized use within and between pathology departments is stirring unhealthy practices of denying reimbursements for this critical and legitimate cytopathology service. This editorial discusses the important concerns raised in this commentary and recommends immediate corrective action. (See also Al-Abbadi MA, et al. Adequate reimbursement is crucial to support cost-effective rapid on-site cytopathology evaluations. CytoJournal 2010;7:22

  19. AMPKα, C/EBPβ, CPT1β, GPR43, PPARγ, and SCD Gene Expression in Single- and Co-cultured Bovine Satellite Cells and Intramuscular Preadipocytes Treated with Palmitic, Stearic, Oleic, and Linoleic Acid.

    Science.gov (United States)

    Choi, S H; Park, S K; Johnson, B J; Chung, K Y; Choi, C W; Kim, K H; Kim, W Y; Smith, B

    2015-03-01

    We previously demonstrated that bovine subcutaneous preadipocytes promote adipogenic gene expression in muscle satellite cells in a co-culture system. Herein we hypothesize that saturated fatty acids would promote adipogenic/lipogenic gene expression, whereas mono- and polyunsaturated fatty acids would have the opposite effect. Bovine semimembranosus satellite cells (BSC) and intramuscular preadipocytes (IPA) were isolated from crossbred steers and cultured with 10% fetal bovine serum (FBS)/Dulbecco's Modified Eagle Medium (DMEM) and 1% antibiotics during the 3-d proliferation period. After proliferation, cells were treated for 3 d with 3% horse serum/DMEM (BSC) or 5% FBS/DMEM (IPA) with antibiotics. Media also contained 10 μg/mL insulin and 10 μg/mL pioglitazone. Subsequently, differentiating BSC and IPA were cultured in their respective media with 40 μM palmitic, stearic, oleic, or linoleic acid for 4 d. Finally, BSC and IPA were single- or co-cultured for an additional 2 h. All fatty acid treatments increased (p = 0.001) carnitine palmitoyltransferase-1 beta (CPT1β) gene expression, but the increase in CPT1β gene expression was especially pronounced in IPA incubated with palmitic and stearic acid (6- to 17- fold increases). Oleic and linoleic acid decreased (p = 0.001) stearoyl-CoA desaturase (SCD) gene expression over 80% in both BSC and IPA. Conversely, palmitic and stearic acid increased SCD gene expression three fold in co-cultured in IPA, and stearic acid increased AMPKα gene expression in single- and co-cultured BSC and IPA. Consistent with our hypothesis, saturated fatty acids, especially stearic acid, promoted adipogenic and lipogenic gene expression, whereas unsaturated fatty acids decreased expression of those genes associated with fatty acid metabolism.

  20. Observation charts with overlapping blood pressure and heart rate graphs do not yield the performance advantage that health professionals assume: an experimental study.

    Science.gov (United States)

    Christofidis, Melany J; Hill, Andrew; Horswill, Mark S; Watson, Marcus O

    2014-03-01

    To investigate whether overlapping blood pressure and heart rate graphs improve chart-users' ability to recognize derangements in these vital signs on hospital observation charts. Many health professionals prefer blood pressure and heart rate graphs to overlap. One justification is the use of a visual cue called the 'Seagull Sign' to detect physiological abnormalities. A 3 × 2 × 2 mixed-design experiment, with three independent variables: participant group, graph format (separate vs. overlapping) and alerting system (integrated colour-based track-and-trigger system present vs. absent). Over 64 experimental trials, 'Seagull-trained' nurses and novices randomly assigned to receive 'Seagull training' or remain untrained, viewed sequences of blood pressure and heart rate observations recorded on four different chart design extracts. The designs represented a crossing of the graph format and alerting system variables. For each design, eight cases contained normal data and eight contained an abnormal systolic blood pressure or heart rate observation (half of which yielded a Seagull Sign on overlapping plots). Participants (tested between January-May 2011) judged whether observations were physiologically normal or abnormal. Across all cases, participants from all groups responded faster and made fewer errors when blood pressure and heart rate observations were graphed separately, especially when a track-and-trigger system was present. Even for 'Seagull-trained' participants viewing 'Seagull Sign available' cases, no advantage of overlapping graphs was found. These findings suggest that overlapping graphs do not yield the performance advantage that many health professionals assume, either for novices or experienced nurses, even when the Seagull Sign is used. © 2013 John Wiley & Sons Ltd.

  1. Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops

    Energy Technology Data Exchange (ETDEWEB)

    Kwon, Young Do; Finzi, Andrés; Wu, Xueling; Dogo-Isonagie, Cajetan; Lee, Lawrence K.; Moore, Lucas R.; Schmidt, Stephen D.; Stuckey, Jonathan; Yang, Yongping; Zhou, Tongqing; Zhu, Jiang; Vicic, David A.; Debnath, Asim K.; Shapiro, Lawrence; Bewley, Carole A.; Mascola, John R.; Sodroski, Joseph G.; Kwong, Peter D. (Harvard-Med); (NIH); (Hawaii); (L.F. Kimball); (Columbia); (VCCRI); (Arkansas); (DFCI)

    2013-03-04

    The HIV-1 envelope (Env) spike (gp120{sub 3}/gp41{sub 3}) undergoes considerable structural rearrangements to mediate virus entry into cells and to evade the host immune response. Engagement of CD4, the primary human receptor, fixes a particular conformation and primes Env for entry. The CD4-bound state, however, is prone to spontaneous inactivation and susceptible to antibody neutralization. How does unliganded HIV-1 maintain CD4-binding capacity and regulate transitions to the CD4-bound state? To define this mechanistically, we determined crystal structures of unliganded core gp120 from HIV-1 clades B, C, and E. Notably, all of these unliganded HIV-1 structures resembled the CD4-bound state. Conformational fixation with ligand selection and thermodynamic analysis of full-length and core gp120 interactions revealed that the tendency of HIV-1 gp120 to adopt the CD4-bound conformation was restrained by the V1/V2- and V3-variable loops. In parallel, we determined the structure of core gp120 in complex with the small molecule, NBD-556, which specifically recognizes the CD4-bound conformation of gp120. Neutralization by NBD-556 indicated that Env spikes on primary isolates rarely assume the CD4-bound conformation spontaneously, although they could do so when quaternary restraints were loosened. Together, the results suggest that the CD4-bound conformation represents a 'ground state' for the gp120 core, with variable loop and quaternary interactions restraining unliganded gp120 from 'snapping' into this conformation. A mechanism of control involving deformations in unliganded structure from a functionally critical state (e.g., the CD4-bound state) provides advantages in terms of HIV-1 Env structural diversity and resistance to antibodies and inhibitors, while maintaining elements essential for entry.

  2. Clinical application of K-CPT on preschool children with attention deficit hyperactivity disorder%持续性操作测验在学龄前儿童注意缺陷多动障碍诊断中应用价值探讨

    Institute of Scientific and Technical Information of China (English)

    谈晓轶; 池霞; 梁沂; 徐亚琴; 王丽; 周影; 张蕾

    2012-01-01

    Objective:To explore the clinical application of Conners' kiddie continuous performance test (K-CPT) on diagnosis in preschool children with attention deficit hyperactivity (ADHD). Methods:Using the diagnostic and statistical manual of Mental disorders (DSM-IV) as a gold standard, K-CPT and parent symptom questionnaire (PSQ) were tested in 41 cases of preschool children with ADHD and evaluated. Results:Compared with DSM-IV,the sensitivity for K-CPT in diagnosing ADHD reached 73.3%, specificity for K-CPT was 81.8%,the false negative rate was 26.7%,and the false positive rate was 18.2%. The coincidence rate amounted 75.7%. The value of kappa was 0.470 (P 0.05) in the detection rate of K-CPT and PSQ. Discussion:K-CPT could be used as an objective diagnostic tool and applied in diagnosis of preschool ADHD.%目的:探讨4~5岁儿童注意力持续测试软件(Conners' kiddie continuous performance test,K-CPT)在诊断学龄前儿童注意缺陷多动障碍(attention deficit hyperactivity disorder,ADHD)中的临床应用价值.方法:以美国精神障碍诊断和统计手册第4版(DSM-IV)为诊断标准,对41例临床诊断ADHD的儿童,进行Conners'父母用简明症状问卷(parent symptom questionnaire,PSQ)调查和K-CPT评估.结果:K-CPT评估结果与DSM-IV诊断标准比较,在ADHD检出率方面无显著性差异(P>0.05).K-CPT诊断学龄前ADHD的灵敏度为73.3%,特异度为81.8%,假阳性率为18.2%,假阴性率为26.7%,符合率为75.7%,Kappa值为0.470 (P< 0.001),K-CPT与金标准之间存在中度一致性.K-CPT和PSQ在患儿阳性检出率方面,差异均无显著性(P>0.05).结论:K-CPT测试结果可作为客观诊断指标,用于学龄前ADHD的协助诊断.

  3. HPLC Determination of CPT-11 and Its Metabolite 7-ethyl-10 HCPT in Incubation System of Rat Liver Microsomes%高效液相色谱法测定大鼠肝微粒体酶孵育体系中伊立替康及其代谢产物的浓度

    Institute of Scientific and Technical Information of China (English)

    张程亮; 徐艳娇; 李喜平; 吴涛; 刘东

    2013-01-01

    目的 建立大鼠肝微粒体酶孵育体系中伊立替康(CPT-11)及其活性代谢产物7-乙基-10羟基喜树碱(SN-38)的HPLC检测方法,并对体外孵育条件进行优化.方法 采用HPLC测定微粒体酶孵育体系中伊立替康及其代谢产物的浓度,用单因素法对各孵育条件进行优化,采用Lineweaver-Burk双倒数法研究羧酸酯酶(CES)的酶促动力学.结果 伊立替康、7-乙基-10羟基喜树碱分别在20~4000、2 ~400 ng·mL-1内线性关系良好.体外酶孵育条件为:伊立替康10 μmol·L-1,肝微粒体蛋白含量0.02mg,孵育时间为15 min.结论 本实验建立的HPLC的方法快捷、灵敏,适用于伊立替康及其代谢产物的测定.体外酶孵育条件的优化,同时也为研究其他多种经羧酸酯酶代谢的药物对伊立替康代谢影响及相互作用的体外研究奠定了基础.%OBJECTIVE To establish an HPLC method for determing irinotecan (CPT-11) and its metabolite 7-ethyl-10 HCPT in rat liver microsome incubation system, and to optimize the incubation conditions. METHODS CPT-11 and SN-38 were determined by HPLC. Single factor design was used to optimize the incubation conditions. RESULTS The linear range of CPT-11 and 7-ethyl-10 HCPT in rat liver microsome incubation system were 20-4 000 ng · mL and 2 -400 ng · mL , respectively. The optimal incubation conditions were as follows; 10 μmol · L CPT-11 , 0. 02 mg liver microsomes and incubation for 15 min. CONCLUSION The HPLC method is accurate and suitable for the determination of CPT-11 and 7-ethyl-10 HCPT in rat liver microsomes. The incubation condition can be applied in drug interaction studies of irinotecan.

  4. Educational Risk Management: Eliminate, Assume, or Transfer.

    Science.gov (United States)

    Shoop, Robert J.; Dunklee, Dennis R.

    1989-01-01

    An Educational Risk Management Plan (ERMP) should be incorporated throughout every school district. Discusses property and liability insurance classifications and features of a good ERMP. (12 references) (MLF)

  5. Assume-Guarantee Reasoning for Deadlock

    Science.gov (United States)

    2006-09-01

    Lecture Notes in Computer Science . Edinburgh, Scotland, July 6–10, 2005. New York... Lecture Notes in Computer Science . Marseille, France, September 3–5, 2003. New York, NY: Springer-Verlag, September 2003. [Angluin 87] Angluin, D...Etessami, K. & Rajamani, S. K. Proceedings of the 17th International Conference on Computer Aided Verification (CAV ’05), Volume 3576 of Lecture Notes in Computer Science .

  6. Winnipeg pediatrician prepares to assume CMA presidency

    OpenAIRE

    Stewart, Jane

    1995-01-01

    The CMA's incoming president is Dr. Jack Armstrong, a Winnipeg pediatrician with a particular interest in aboriginal issues. Armstrong, who graduated from the University of Manitoba in 1966, considers himself a team player. “You have to be a part of a team. My job is to try to be as good a spokesperson as possible, along with the other team members, for the physicians of the country.”

  7. Luther's thought assumed form in polemics

    DEFF Research Database (Denmark)

    Vind, Anna

    2014-01-01

    genres Luther’s versatile use of a range of polemical devices countered positions he regarded as false. The necessity of opposing such positions provoked his expansion and deepening of formulations of doctrine and ecclesiastical practice on various topics, including Christian freedom, the external...... character of God’s Word, and other doctrines. Luther’s polemic also served pastoral purposes, defending the faithful against error....

  8. Tunnel Face Stability & New CPT Applications

    NARCIS (Netherlands)

    Broere, W.

    2001-01-01

    Nearly all tunnels bored in soft soils have encountered problems with the stability of the tunnel face. In several cases these problems led to an extended stand-still of the boring process. A better understanding of the face stability, and of the soil conditions around the tunnel boring machine, can

  9. Flat roof integration. CPT solar (AET IV)

    Energy Technology Data Exchange (ETDEWEB)

    Chianese, D.; Pola, I.; Bernasconi, A.; Bura, E.; Cereghetti, N.; Realini, A.; Pasinelli, P.; Rioggi, S.

    2007-11-15

    This illustrated final report for the Swiss Federal Office of Energy (SFOE) takes a look at a 15.4 kWp solar power installation in Trevano, Switzerland, that features flexible amorphous silicon triple-junction modules, mounted nearly horizontally and directly laminated to flexible polyolefin membranes that form the covering of a flat roof. The main objective of this study was to verify in which order of magnitude the better thermal behaviour of amorphous silicon cells can compensate for losses due to the quasi-horizontal roof integration (lower irradiation and higher reflection), and thus be competitive in the flat roof construction and refurbishment markets. The modules used and their characteristics are described. Performance, temperature levels and energy-production are reviewed for the panels of the installation. The performance of the inverter used is also reviewed. Data on temperatures and production are presented in graphical form and optical losses are examined.

  10. CPT Magnetometer with Atomic Energy Level Modulation

    Institute of Scientific and Technical Information of China (English)

    LIU Guo-Bin; DU Run-Chang; LIU Chao-Yang; GU Si-Hong

    2008-01-01

    We propose and experimentally investigate a coherent population trapping state based magnetometer prototype with87 Rb atoms.Through modulating Zeeman sublevels with an ac magnetic field,not only a phase sensitive detection scheme suitable for miniature magnetometer is realized,but also the detection resolution of magnetic field intensity could be improved by a factor of two.Our study result indicates that it is a promising low power consumption miniature sensitive low magnetic field sensor offering spatially resolved measurement at the sub-millimetre level.

  11. An Alternative Method for Estimation of Gurney Velocity Based on Assumed Detonation Products%基于不同爆轰产物的格尼速度估算新方法

    Institute of Scientific and Technical Information of China (English)

    Mohammad Hossein Keshavarz

    2006-01-01

    A new method for prediction of Gurney velocity of explosives is introduced in which energy output is correlated with the heat of detonation,the number of moles of gaseous products of detonation per gram of explosive and the average molecular weight of gaseous products. It is assumed that the CHNO explosive reacts to form products composed of N2,CO,H2O,CO2,H2,O2 and C(s) as determined by the oxygen balance of the unreacted compound. Good agreement is obtained between measured and calculated values of Gurney velocity as compared to previous correlations which assumed the reaction products to consist of N2,H2O,CO2 and either C(s) or O2.

  12. Phase II study of irinotecan (CPT-11) administered every 2 weeks as treatment for patients with colorectal cancer resistant to previous treatment with 5-fluorouracil-based therapies: comparison of two different dose schedules (250 and 200 mg/m2) according to toxicity prognostic factors.

    Science.gov (United States)

    Saigi, Eugeni; Salut, Antonieta; Campos, Juan Manuel; Losa, Ferran; Manzano, Hermini; Batiste-Alentorn, Eduard; Acusa, Angels; Vélez de Mendizabal, Edelmira; Guasch, Inmaculada; Antón, Isabel

    2004-10-01

    Our objective was to assess the antitumoral activity and toxicity of irinotecan (CPT-11) 60-min i.v. infusion every 2 weeks as second-line monotherapy of advanced colorectal cancer. Two doses were studied (250 and 200 mg/m) according to the risk of developing toxicity. Two groups of patients were studied: high-risk group (HR, 200 mg/m, n = 45; Karnofsky score 60-80% and/or the record of prior pelvic irradiation) and low-risk-group (LR, 250 mg/m, n = 51; Karnofsky score >80% and without prior pelvic irradiation). The mean number of cycles per patient was 7: 6.6 (HR group) and 8.3 (LR group). Median RDI was 0.96. The overall response rate was 8.9% [95% confidence interval (CI) 2.5-21.2%; HR group] and 15.7% (95% CI 7.0-28.5%; LR group), respectively. The LR group showed two complete responses and a higher percentage of stable disease (56.9 versus 33.3% in HR group). The median survival was 7.1 months (95% CI 5.2-8.9 months, HR group) and 11.7 months (95% CI 8.4-15.1 months, LR group). The median time to disease progression was 3.2 months (95% CI 1.0-5.4 months, HR group) and 5.3 months (95% CI 3.8-6.7 months, LR group). Both CPT-11 treatments were well tolerated. Grade 3/4 toxicity incidence was low, e.g. granulocytopenia (7% of patients in HR group and 9% in LR group) and delayed diarrhea (18% of patients in HR group and 14% in LR group). We conclude that the treatment of patients with the adjusted dose of CPT-11 according to prognostic factors for toxicity resulted in the improved toxicity profile, but showed poorer efficacy outcome. Therefore, the dose reduction in patients with low performance and treated with radiotherapy needs further investigation to provide some new insights on the benefit:risk ratio of such treatment.

  13. Registration of hydrogen-like leptonic bound states (e sup -mu sup +) and (e sup +mu sup -) in reactions of high-energy scattering of polarized electrons and positrons by nuclei with Z propor to 100 and analysis of CPT invariance

    CERN Document Server

    Choban, E A

    2003-01-01

    The cross-sections for the reactions of muonium (anti-muonium) production in the high-energy electron (positron) scattering by nuclei e sup - (e sup +)+Z->Z + M sup 0 (anti M sup 0)+mu sup - (mu sup +) are calculated in dependence on energy and polarization of the initial electron (positron) and polarization of the final mu sup - (mu sup +)-meson. Since this is a coherent phenomenon the cross-sections are proportional to Z sup 2. For Z propor to 100, due to the factor Z sup 2 , the cross-sections are large enough to be measured at the energies available for the HERA Collider at DESY. The results are discussed in connection with a test of CPT invariance. (orig.)

  14. 中国应对全球气候变化的伦理责任评估%Assessment of Ethical Responsibility Assumed by China to Address Climate Change

    Institute of Scientific and Technical Information of China (English)

    艾瑞克·斯奇克; 郝晓雅; 史军

    2011-01-01

    It is a global task to address climate change. China also assumes the responsibility. From eight ethical dimensions, the Ethical Dimensions of Climate Change (EDCC) analyzes the ethical responsibilities China needs take in the context of global climate change, points out the great challenges that China faces while performing the duty, including liability for damage, the development of new technology and new energy, international and domestic participation, and the fairness and justice of procedure, constructs a multi-level climate governance framework that is composed of Chinese government, other domestic participants and foreign institutions, and provides proposals and references for policy-making.%应对气候变化是一项全球性的任务,中国承担着不可推卸的责任。从《伦理维度应对气候的变化》(EDCC)白皮书提出的八个伦理维度分析了中国应对全球气候变化需承担的伦理责任,指出了中国特例下履行责任所面临的赔偿责任、开发新技术与新能源、国际国内参与、程序公平与正义等重大挑战,构建了中国政府、国内其他参与者及境外参与机构组成的多层次气候治理框架,提供了决策参考和建议。

  15. Constraints on flavor-dependent long range forces from solar neutrinos and KamLAND

    CERN Document Server

    Bandyopadhyay, A; Joshipura, A S; Bandyopadhyay, Abhijit; Dighe, Amol; Joshipura, Anjan S.

    2006-01-01

    Flavor-dependent long range (LR) leptonic forces, like those mediated by the $L_e-L_\\mu$ or $L_e -L_\\tau$ gauge bosons, constitute a minimal extension of the standard model that preserves its renormalizability. We study the impact of such interactions on the solar neutrino oscillations when the interaction range $R_{LR}$ is much larger than the Earth-Sun distance. The LR potential can dominate over the standard charged current potential inside the Sun in spite of strong constraints on the coupling $\\alpha$ of the LR force coming from the atmospheric neutrino data and laboratory search for new forces. We demonstrate that the solar and atmospheric neutrino mass scales do not get trivially decoupled even if $\\theta_{13}$ is vanishingly small. In addition, for $\\alpha \\gsim 10^{-52}$ and normal hierarchy, resonant enhancement of $\\theta_{13}$ results in nontrivial energy dependent effects on the $\

  16. Predizendo redução da CPT em pacientes com CVF reduzida e relação VEF1/CVF normal ou elevada Predicting reduced TLC in patients with low FVC and a normal or elevated FEV1/FVC ratio

    Directory of Open Access Journals (Sweden)

    Luiz Carlos D'Aquino

    2010-08-01

    Full Text Available OBJETIVO: Utilizar os dados clínicos e espirométricos para distinguir entre os padrões restritivo e inespecífico dos resultados dos testes de função pulmonar em pacientes com CVF reduzida e relação VEF1/CVF normal ou elevada. MÉTODOS: Foram avaliados resultados de testes de função pulmonar de 211 pacientes adultos submetidos à espirometria e a medidas de volumes pulmonares. O diagnóstico clínico na solicitação do exame e diversos dados funcionais foram utilizados para diferenciar pacientes com o padrão restritivo "verdadeiro" (CPT reduzida daqueles com o padrão inespecífico (CPT normal. RESULTADOS: Na amostra estudada, a CPT estava reduzida em 144 casos e estava dentro da faixa normal em 67. As causas mais comuns do padrão inespecífico foram doenças pulmonares obstrutivas, insuficiência cardíaca congestiva, obesidade, bronquiolite, doenças intersticiais e doenças neuromusculares. Em pacientes com hipótese diagnóstica de fibrose pulmonar, doenças pleurais ou doenças da parede torácica, o valor preditivo positivo (VPP para restrição foi > 90%. Em homens, a CVF 0% teve um VPP para restrição de 89,5%. Após regressão logística, uma escala de pontos foi desenvolvida para predizer o padrão restritivo. CONCLUSÕES: O padrão restritivo pode ser identificado com segurança em diversos casos com VEF1 e CVF reduzidos e relação VEF1/CVF normal usando-se um algoritmo que leva em conta o diagnóstico clínico e alguns achados espirométricos.OBJECTIVE: To use clinical and spirometry findings in order to distinguish between the restrictive and nonspecific patterns of pulmonary function test results in patients with low FVC and a normal or elevated FEV1/FVC ratio. METHODS: We analyzed the pulmonary function test results of 211 adult patients submitted to spirometry and lung volume measurements. We used the clinical diagnosis at the time spirometry was ordered, together with various functional data, in order to

  17. 上海地区土体抗剪强度与静力触探比贯入阻力相关关系研究%Correlations of soil shear strength with specific penetration resistance of CPT in Shanghai area

    Institute of Scientific and Technical Information of China (English)

    马海鹏; 陈祖煜; 于沭

    2014-01-01

    基于上海地区19个工程共201组数据,通过黏土、粉质黏土和粉砂在上海地区土层中的分布,比贯入阻力Ps,室内固结快剪试验黏聚力cu和摩擦角u,孔隙比e,塑性指数Ip沿土层深度的变化,分析得到3种土类的抗剪强度与比贯入阻力的相关关系,并总结了国内软土地区土体抗剪强度与静力触探比贯入阻力之间的相关关系。本文得到黏土的相关关系与以往的经验公式相近,同时给出了原位土层粉质黏土和粉砂的相关关系。区别不同土类使得相关关系可用性提高,在工程应用中更加合理。根据本文相关关系,通过静力触探比贯入阻力可以得到不同土层的抗剪强度值,进而应用于基坑稳定计算。本文研究的结果可以应用于海相沉积土的勘察和工程设计工作。%Two hundred and one groups of cone penetration test (CPT) data from 19 projects in Shanghai are adopted. The distribution of clay, silty clay and silt in Shanghai area are obtained. The specific penetration resistance (Ps), cohesive strength (cu) and frictional angle (u) of consolidated quick shear test, void ratio (e), and plasticity index (Ip) are varied along the soil depth. The soil shear strength (Su) of clay, silty clay and silt are correlated with specific penetration resistance (Ps) of CPT. The correlations between Su and Ps are summarized for various types of soft soils in China. It has been found that the correlation coefficients of clays obtained from this study are similar to the published data. Also the in situ soil correlations of silty clay and silt are given. These correlations of Su with Ps are useful for classified soil and valuable to engineering application. According to correlations in this paper, the calibrated correlation coefficients can be used to determine Su based on Ps for foundation pit stability calculation. The results of the study can be used for geological investigation and

  18. Improving Technology Education: Understanding Reform--Assuming Responsibility.

    Science.gov (United States)

    Bybee, Rodger W.

    2003-01-01

    Presents a strategic framework for standards-based reform: (1) dissemination (develop awareness); (2) interpretation (increase understanding and support); (3) implementation (change policies, programs, and practices); (4) evaluation (monitor and adjust); and (5) revision (improve efficiency and influence of standards). Outlines roles for various…

  19. Parameterizing deep convection using the assumed probability density function method

    Directory of Open Access Journals (Sweden)

    R. L. Storer

    2014-06-01

    Full Text Available Due to their coarse horizontal resolution, present-day climate models must parameterize deep convection. This paper presents single-column simulations of deep convection using a probability density function (PDF parameterization. The PDF parameterization predicts the PDF of subgrid variability of turbulence, clouds, and hydrometeors. That variability is interfaced to a prognostic microphysics scheme using a Monte Carlo sampling method. The PDF parameterization is used to simulate tropical deep convection, the transition from shallow to deep convection over land, and mid-latitude deep convection. These parameterized single-column simulations are compared with 3-D reference simulations. The agreement is satisfactory except when the convective forcing is weak. The same PDF parameterization is also used to simulate shallow cumulus and stratocumulus layers. The PDF method is sufficiently general to adequately simulate these five deep, shallow, and stratiform cloud cases with a single equation set. This raises hopes that it may be possible in the future, with further refinements at coarse time step and grid spacing, to parameterize all cloud types in a large-scale model in a unified way.

  20. Listeners Invest in an Assumed Other's Perspective Despite Cognitive Cost

    Science.gov (United States)

    Duran, Nicholas D.; Dale, Rick; Kreuz, Roger J.

    2011-01-01

    We explored perspective-taking behavior in a visuospatial mental rotation task that requires listeners to adopt an egocentric or "other-centric" frame of reference. In the current task, objects could be interpreted relative to the point-of-view of the listener (egocentric) or of a simulated partner (other-centric). Across three studies, we…

  1. Assuming too much? Participatory water resource governance in South Africa.

    Science.gov (United States)

    Brown, Julia

    2011-01-01

    This paper argues that participation in natural resource management, which is often coupled with moves for more local ownership of decision making, is based on three sets of assumptions: about the role of the state, the universality of application of such approaches and the transformatory potential of institutional reform. The validity of these assumptions requires investigation in view of the rapid institutionalisation and scaling-up of participatory approaches, particularly in developing country contexts. Post-apartheid South Africa is widely recognised as a pioneer of participatory and devolutionary approaches, particularly in the field of water resources. It is 12 years since the promulgation of the forward-thinking 1998 National Water Act, and thus an opportune moment to reflect on South Africa's experiences of participatory governance. Drawing on empirical research covering the establishment of the first Catchment Management Agency, and the transformation of existing Irrigation Boards into more inclusive Water User Associations in the Inkomati Water Management Area, it emerges that there may be fundamental weaknesses in the participatory model and underlying assumptions, and indeed such approaches may actually reinforce inequitable outcomes: the legacy of long-established institutional frameworks and powerful actors therein continues to exert influence in post-apartheid South Africa, and has the potential to subvert the democratic and redistributive potential of the water reforms. It is argued that a reassessment of the role of the state is necessary: where there is extreme heterogeneity in challenging catchments more, rather than less, state intervention may be required to uphold the interests of marginalised groups and effect redistribution.

  2. The assumed relation between occupation and inequality in health

    DEFF Research Database (Denmark)

    Madsen, Jacob; Kanstrup, Anne Marie; Josephsson, Staffan

    2016-01-01

    Background: Occupational science and therapy scholars have argued that research on inequality in health is needed. Simultaneously, a knowledge gap between how to understand and take action on health inequalities exists in occupational science and therapy. Objective: To identify how inequality...... in health, high-risk areas of health, and engagement in health for low-income adult citizens have been described and conceptualized in contemporary occupational science and therapy literature. Material and methods: A structured literature review of 37 publications in occupational science and therapy...... on assumptions regarding the relation between occupation and inequality in health, and statements on the need to explore this relation. Conclusion: Basic theory and reasoning, as well as empirical studies, on inequality in health are missing in occupational science and therapy. Based on the findings...

  3. Technology Transfer Center to Assume Patenting and Licensing Responsibilities | Poster

    Science.gov (United States)

    The NCI Technology Transfer Center (TTC) is undergoing a reorganization that will bring patenting and licensing responsibilities to the Shady Grove and Frederick offices by October 2015. The reorganization is a result of an effort begun in 2014 by NIH to improve the organizational structure of technology transfer at NIH to meet the rapid rate of change within science, technology, and industry, and to better align the science and laboratory goals with the licensing and patenting process.

  4. From Relational Interfaces to Assume-Guarantee Contracts

    Science.gov (United States)

    2014-03-18

    surprisingly, the ba - sic operation of serial composition of interfaces is not pre- served. Specifically, composing two interfaces I1 and I2, and then...Rapport de recherche RR-8147, Nov. 2012. [7] S. S. Bauer , A. David, R. Hennicker, K. G. Larsen, A. Legay et al., “Moving from specifications to

  5. Don't Assume Deaf Students are Visual Learners.

    Science.gov (United States)

    Marschark, Marc; Paivio, Allan; Spencer, Linda J; Durkin, Andreana; Borgna, Georgianna; Convertino, Carol; Machmer, Elizabeth

    2017-02-01

    In the education of deaf learners, from primary school to postsecondary settings, it frequently is suggested that deaf students are visual learners. That assumption appears to be based on the visual nature of signed languages-used by some but not all deaf individuals-and the fact that with greater hearing losses, deaf students will rely relatively more on vision than audition. However, the questions of whether individuals with hearing loss are more likely to be visual learners than verbal learners or more likely than hearing peers to be visual learners have not been empirically explored. Several recent studies, in fact, have indicated that hearing learners typically perform as well or better than deaf learners on a variety of visual-spatial tasks. The present study used two standardized instruments to examine learning styles among college deaf students who primarily rely on sign language or spoken language and their hearing peers. The visual-verbal dimension was of particular interest. Consistent with recent indirect findings, results indicated that deaf students are no more likely than hearing students to be visual learners and are no stronger in their visual skills and habits than their verbal skills and habits, nor are deaf students' visual orientations associated with sign language skills. The results clearly have specific implications for the educating of deaf learners.

  6. Technology Transfer Center to Assume Patenting and Licensing Responsibilities | Poster

    Science.gov (United States)

    The NCI Technology Transfer Center (TTC) is undergoing a reorganization that will bring patenting and licensing responsibilities to the Shady Grove and Frederick offices by October 2015. The reorganization is a result of an effort begun in 2014 by NIH to improve the organizational structure of technology transfer at NIH to meet the rapid rate of change within science, technology, and industry, and to better align the science and laboratory goals with the licensing and patenting process.

  7. The assumed relation between occupation and inequality in health

    DEFF Research Database (Denmark)

    Madsen, Jacob Østergaard; Kanstrup, Anne Marie; Josephsson, Staffan

    2015-01-01

    Background: Occupational science and therapy scholars have argued that research on inequality in health is needed. Simultaneously, a knowledge gap between how to understand and take action on health inequalities exists in occupational science and therapy. Objective: To identify how inequality...... in health, high-risk areas of health, and engagement in health for low-income adult citizens have been described and conceptualized in contemporary occupational science and therapy literature. Material and methods: A structured literature review of 37 publications in occupational science and therapy...... on assumptions regarding the relation between occupation and inequality in health, and statements on the need to explore this relation. Conclusion: Basic theory and reasoning, as well as empirical studies, on inequality in health are missing in occupational science and therapy. Based on the findings...

  8. Assuming the role of mitochondria in mycobacterial infection.

    Science.gov (United States)

    Dubey, Rikesh K

    2016-12-01

    Tuberculosis is one of the leading causes of death by Mycobacterium tuberculosis (Mtb) affecting millions of people worldwide. Mycobacterium species enter host macrophages during infection and target various cellular organelles and their function for their own benefit. Mitochondria appear to be among the important targets for bacterial pathogens. Mtb and other pathogenic bacteria secrete various proteins that initiate structural changes in mitochondria to modulate its function. Additionally, virulent mycobacteria interfere with the balance between pro- and anti-apoptotic factors to inhibit apoptosis and, in later stages, promote necrosis. Furthermore, mitochondria perform multiple biological functions in the cell, and the inhibition of these functions by bacterial proteins promotes Mtb survival, growth, and successful infection. Copyright © 2016 Asian-African Society for Mycobacteriology. Published by Elsevier Ltd. All rights reserved.

  9. Knowing, Assuming, and Theorizing: Activities To Teach about Theory.

    Science.gov (United States)

    Beins, Bernard C.

    The two-part activity outlined in this paper reveals to undergraduate students that assumptions made in theory building remain unquestioned until one steps outside the initial realm of expectations, and that theories adopted have a demonstrable impact on behaviors. Part I defines a theory, describes the roles of assumptions and knowledge in…

  10. Inferring word meanings by assuming that speakers are informative.

    Science.gov (United States)

    Frank, Michael C; Goodman, Noah D

    2014-12-01

    Language comprehension is more than a process of decoding the literal meaning of a speaker's utterance. Instead, by making the assumption that speakers choose their words to be informative in context, listeners routinely make pragmatic inferences that go beyond the linguistic data. If language learners make these same assumptions, they should be able to infer word meanings in otherwise ambiguous situations. We use probabilistic tools to formalize these kinds of informativeness inferences-extending a model of pragmatic language comprehension to the acquisition setting-and present four experiments whose data suggest that preschool children can use informativeness to infer word meanings and that adult judgments track quantitatively with informativeness.

  11. Chinese Enterprises:Time to Assume More Social Responsibilit

    Institute of Scientific and Technical Information of China (English)

    金碚

    2008-01-01

    On November 28th and 29th, the Annual Meeting onEnterprise Competitiveness sponsored by China BusinessJournal was held with the theme "corporate profitability,going global and social responsibility."Seeminglyunconnected, these three issues, which would otherwise

  12. Some Assumed Characteristics of Voluntarily Childfree Women and Men.

    Science.gov (United States)

    Jamison, Pollyann H.; And Others

    1979-01-01

    Experiments were conducted to assess students' perceptions from written descriptions of voluntarily childfree women and men. Ratings of the childfree man were less favorable than those for the childfree woman, suggesting greater bias against childfree men than women. (Author)

  13. Trajectory Simulation of Meteors Assuming Mass Loss and Fragmentation

    Science.gov (United States)

    Allen, Gary A., Jr.; Prabhu, Dinesh K.; Saunders, David A

    2015-01-01

    Program used to simulate atmospheric flight trajectories of entry capsules [1] Includes models of atmospheres of different planetary destinations - Earth, Mars, Venus, Jupiter, Saturn, Uranus, Titan, ... Solves 3-­-degrees of freedom (3DoF) equations for a single body treated as a point mass. Also supports 6-DoF trajectory simula4on and Monte Carlo analyses. Uses Fehlberg-­-Runge-­-Kuna (4th-5th order) time integraion with automaic step size control. Includes rotating spheroidal planet with gravitational field having a J2 harmonic. Includes a variety of engineering aerodynamic and heat flux models. Capable of specifying events - heatshield jettison, parachute deployment, etc. - at predefined altitudes or Mach number. Has material thermal response models of typical aerospace materials integrated.

  14. Letter: Accuracy of Glucometers Should Not Be Assumed

    Science.gov (United States)

    2007-11-01

    patients in our study had glucose differences of at least 10 mg/dL between the POC and laboratory methods , which may be a large enough difference for the...M, et al. Evaluation of sev- eral blood glucose monitoring systems for whole blood glucose measurements at the point of care. 52nd Annual AACC Meeting

  15. Sonic CPT Probing in Support of DNAPL Characterization

    Science.gov (United States)

    2012-05-22

    which then causes either de-coupling of the soil /shaft system or liquefaction of adjacent soi I s . This greatly diminishes shaft friction, which...resistance of the soil along the side of the rod string. The reduction of the frictional resistance allows a greater proportion of available push force to...better in sands and gravels, whereas lower frequencies/higher amplitudes yield better results in clayey soils . In addition, a new rod clamping

  16. Remarks on Lorentz and CPT violation in field theory

    CERN Document Server

    Mariz, T; Passos, E

    2006-01-01

    In this brief review we explicitly calculate the radiative corrections to the Chern-Simons-like term in the cases of zero and finite temperature, and in the gravity theory. Our results are obtained under the general guidance of dimensional regularization.

  17. CPT-Violating Leptogenesis induced by Gravitational Defects

    CERN Document Server

    Mavromatos, Nick E

    2012-01-01

    We explore leptogenesis induced by the propagation of neutrinos in gravitational backgrounds that may occur in string theory. The first background is due to linear dilatons and the associated Kalb-Ramond field (axion) in four non-compact space-time dimensions of the string, and can be described within the framework of local effective lagrangians. The axion is linear in the time coordinate of the Einstein frame and gives rise to a constant torsion which couples to the fermion spin through a gravitational covariant derivative. This leads to different energy-momentum dispersion relations for fermions and anti-fermions and hence leptogenesis. The next two backgrounds go beyond the local effective lagrangian framework. One is a stochastic (Lorentz Violating) Finsler metric which again leads to different dispersion relations between fermions and antifermions. The third background of primary interest is the one due to populations of stochastically fluctuating point-like space-time defects that can be encountered in ...

  18. CPT White Paper on Tier-1 Computing Resource Needs

    CERN Document Server

    CERN. Geneva. CPT Project

    2006-01-01

    In the summer of 2005, CMS like the other LHC experiments published a Computing Technical Design Report (C-TDR) for the LHCC, which describes the CMS computing models as a distributed system of Tier-0, Tier-1, and Tier-2 regional computing centers, and the CERN analysis facility, the CMS-CAF. The C-TDR contains information on resource needs for the different computing tiers that are derived from a set of input assumptions and desiderata on how to achieve high-throughput and a robust computing environment. At the CERN Computing Resources Review Board meeting in October 2005, the funding agencies agreed on a Memorandum of Understanding (MoU) describing the worldwide collaboration on LHC computing (WLCG). In preparation for this meeting the LCG project had put together information from countries regarding their pledges for computing resources at Tier-1 and Tier-2 centers. These pledges include the amount of CPU power, disk storage, tape storage library space, and network connectivity for each of the LHC experime...

  19. The possibility to observe the non-standard interaction by the Hyperkamiokande atmospheric neutrino experiment

    Directory of Open Access Journals (Sweden)

    Shinya Fukasawa

    2017-01-01

    Full Text Available It was suggested that a tension between the mass-squared differences obtained from the solar neutrino and KamLAND experiments can be solved by introducing the non-standard flavor-dependent interaction in neutrino propagation. In this paper we discuss the possibility to test such a hypothesis by atmospheric neutrino observations at the future Hyper-Kamiokande experiment. Assuming that the mass hierarchy is known, we find that the best-fit value from the solar neutrino and KamLAND data can be tested at more than 8σ, while the one from the global analysis can be examined at 5.0σ (1.4σ for the normal (inverted mass hierarchy.

  20. Sensitivity of atmospheric neutrino experiments to neutrino non-standard interactions

    CERN Document Server

    Fukasawa, Shinya

    2016-01-01

    We study the sensitivity of atmospheric neutrino experiments to the neutrino non-standard interactions (NSI) which is motivated by the tension between the two mass squared differences extracted from the KamLAND and solar neutrino experiments. In this study the sensitivity of the future Hyper-Kamiokande experiments for 4438 days to NSI is shown. Assuming that the mass hierarchy is known, we find that the best-fit value from the solar neutrino and KamLAND data can be tested at more than 8 $\\sigma$, while the one from the global analysis can be examined at 5.0 $\\sigma$ (1.4 $\\sigma$) for the normal (inverted) mass hierarchy.