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Sample records for kal renganathan sharma

  1. Juhtimisguru Robin Sharma naudib vaikusehetki / Robin Sharma ; interv. Kristo Kiviorg

    Index Scriptorium Estoniae

    Sharma, Robin

    2008-01-01

    Ilmunud ka: Delovõje Vedomosti 5. märts lk. 12. Juhtimisguru Robin Sharma leiab, et inimesed peaksid leidma päevas tunni iseenese jaoks, sest see aitab leida õiged perspektiivid ning loob eelduse heade ideede tekkeks. Lisa: Robin S. Sharma. Kommenteerivad Kadri Arula ja Asko Talu

  2. Robin Sharma : juhtimine on lihtne / Robin Sharma ; intervjueerinud Nelli Pello

    Index Scriptorium Estoniae

    Sharma, Robin

    2008-01-01

    Eestit külastanud maailma tunnustatumaid koolitajaid Robin Sharma, kes viis läbi seminari "Eestvedamise meistriklass", vastab küsimustele Eesti-muljete ja juhtimise kohta. Lisa: Robin Sharma mõtteteri. Kommenteerivad: Indrek Pertelson, Anne Samlik

  3. Juhtimisguru Robin Sharma naudib vaikusehetki / Robin Sharma ; interv. Kristo Kiviorg

    Index Scriptorium Estoniae

    Sharma, Robin

    2008-01-01

    Ilmunud ka: Delovõje Vedomosti 5. märts lk. 12. Juhtimisguru Robin Sharma leiab, et inimesed peaksid leidma päevas tunni iseenese jaoks, sest see aitab leida õiged perspektiivid ning loob eelduse heade ideede tekkeks. Lisa: Robin S. Sharma. Kommenteerivad Kadri Arula ja Asko Talu

  4. Robin Sharma : juhtimine on lihtne / Robin Sharma ; intervjueerinud Nelli Pello

    Index Scriptorium Estoniae

    Sharma, Robin

    2008-01-01

    Eestit külastanud maailma tunnustatumaid koolitajaid Robin Sharma, kes viis läbi seminari "Eestvedamise meistriklass", vastab küsimustele Eesti-muljete ja juhtimise kohta. Lisa: Robin Sharma mõtteteri. Kommenteerivad: Indrek Pertelson, Anne Samlik

  5. The Sharma-Parthasarathy stochastic two-body problem

    Energy Technology Data Exchange (ETDEWEB)

    Cresson, J. [LMAP/Université de Pau, 64013 Pau (France); SYRTE/Observatoire de Paris, 75014 Paris (France); Pierret, F. [SYRTE/Observatoire de Paris, 75014 Paris (France); Puig, B. [IPRA/Université de Pau, 64013 Pau (France)

    2015-03-15

    We study the Sharma-Parthasarathy stochastic two-body problem introduced by Sharma and Parthasarathy in [“Dynamics of a stochastically perturbed two-body problem,” Proc. R. Soc. A 463, 979-1003 (2007)]. In particular, we focus on the preservation of some fundamental features of the classical two-body problem like the Hamiltonian structure and first integrals in the stochastic case. Numerical simulations are performed which illustrate the dynamical behaviour of the osculating elements as the semi-major axis, the eccentricity, and the pericenter. We also derive a stochastic version of Gauss’s equations in the planar case.

  6. The Sharma-Parthasarathy stochastic two-body problem

    Science.gov (United States)

    Cresson, J.; Pierret, F.; Puig, B.

    2015-03-01

    We study the Sharma-Parthasarathy stochastic two-body problem introduced by Sharma and Parthasarathy in ["Dynamics of a stochastically perturbed two-body problem," Proc. R. Soc. A 463, 979-1003 (2007)]. In particular, we focus on the preservation of some fundamental features of the classical two-body problem like the Hamiltonian structure and first integrals in the stochastic case. Numerical simulations are performed which illustrate the dynamical behaviour of the osculating elements as the semi-major axis, the eccentricity, and the pericenter. We also derive a stochastic version of Gauss's equations in the planar case.

  7. Kaitsetud kurjuse küüsis / Nabila Sharma ; intervjueerinud Krista Link

    Index Scriptorium Estoniae

    Sharma, Nabila

    2013-01-01

    Intervjuus räägib autobiograafilise raamatu autor Nabila Sharma laste seksuaalsest väärkohtlemisest. Tutvustus: Sharma, Nabila. Julmus : traagiline lugu väikese tüdruku süütuse röövimisest. Sinisukk, 2013

  8. Bäcklund Transformation and New Exact Solutions of the Sharma-Tasso-Olver Equation

    Directory of Open Access Journals (Sweden)

    Lin Jianming

    2011-01-01

    Full Text Available The Sharma-Tasso-Olver (STO equation is investigated. The Painlevé analysis is efficiently used for analytic study of this equation. The Bäcklund transformations and some new exact solutions are formally derived.

  9. Sistemik Hipertansiyonlu Olgularda Santral Kornea Kalınl??? ve Retina Sinir Lifi Tabakası Kalınl???

    OpenAIRE

    ERG?N, Ahmet; Çakmak, Yasin; GÜLLÜ, Reyhan

    2007-01-01

    Bu çalışma, sistemik hipertansiyonlu hastalarda santral kornea kalınl??? ve retina sinir lifi tabakası kalınl???nı ara?tırmak için planland?. Olguların santral kornea kalınlıkları (SKK) Pacline Optikon Ultrasonik pakimetre cihazı ile ölçüldü. Retina sinir lifi tabakası kalınl??? (RSLTK) ölçümü ise NFA II, GDx VCC cihazı ile yapıld?. Her olgu için üç ölçüm yapıld?, bunlardan en net olanı hesapland?. Sağlıklı bireyler ile sistemik hipertansiyonu olan hastalar arasında tüm ölçümler açıs?ndan ist...

  10. Expression of the KAL gene in multiple neuronal sites during chicken development.

    OpenAIRE

    Legouis, R; Lievre, C A; Leibovici, M; Lapointe, F.; Petit, C.

    1993-01-01

    The human KAL gene is responsible for the X chromosome-linked Kallmann syndrome. A partial cDNA sequence from the chicken KAL homologue was determined and used to study expression of the KAL gene, by in situ hybridization, during chicken development, from day 6 of incubation. The KAL gene is mainly expressed in neurons of the central nervous system during the second half of embryonic life. High levels of transcript were detected in mitral neurons of the olfactory bulbs, in striatal neurons, i...

  11. The analysis of repeated failures of pipelines in Kal'chinskoe oil field

    Science.gov (United States)

    Shavlov, E. N.; Brusnik, O. V.; Lukjanov, V. G.

    2016-09-01

    The paper presents the chemical analysis of oilfield water and hydraulic analysis of the liquid flow in Kal'chinskoe oil field pipeline that allow detecting the causes of the internal corrosion processes. The inhibitor protection is suggested to reduce the corrosion rate in the pipelines of Kal'chinskoe oil field. Based on the analysis of the pipeline failures, it is suggested to replace steel pipes by fiberglass pipes.

  12. Intersectional Gene Expression in Zebrafish Using the Split KalTA4 System.

    Science.gov (United States)

    Almeida, Rafael Gois; Lyons, David Anthony

    2015-12-01

    In this study, we describe the adaptation of the split Gal4 system for zebrafish. The Gal4-UAS system is widely used for expression of genes-of-interest by crossing driver lines expressing the transcription factor Gal4 (under the control of the promoter of interest) with reporter lines where upstream activating sequence (UAS) repeats (recognized by Gal4) drive expression of the genes-of-interest. In the Split Gal4 system, hemi-drivers separately encode the DNA-binding domain (DBD) and the activation domain (AD) of Gal4. When encoded under two different promoters, only those cells in the intersection of the promoters' expression pattern and in which both promoters are active reconstitute a functional Gal4 and activate expression from a UAS-driven transgene. We split the zebrafish-optimized version of Gal4, KalTA4, and generated a hemi-driver encoding the KalTA4 DBD and a hemi-driver encoding KalTA4's AD. We show that split KalTA4 domains can assemble in vivo and transactivate a UAS reporter transgene and that each hemi-driver alone cannot transactivate the reporter. Also, transactivation can happen in several cell types, with similar efficiency to intact KalTA4. Finally, in transient mosaic expression assays, we show that when hemi-drivers are preceded by two distinct promoters, they restrict the expression of an UAS-driven reporter from a broader pattern (sox10) to its constituent smaller neuronal pattern. The Split KalTA4 system should be useful for expression of genes-of-interest in an intersectional manner, allowing for more refined manipulations of cell populations in zebrafish.

  13. Optical properties of the Bi+ center in KAlCl4

    CERN Document Server

    Veber, A A; Usovich, O V; Fattakhova, Z T; Haula, E V; Korchak, V N; Trusov, L A; Kazin, P E; Sulimov, V B; Tsvetkov, V B

    2013-01-01

    Temperature behavior of the Bi+ center emission, excitation bands and luminescence decay law in KAlCl4 crystal are investigated. Abrupt changes of the monocation optical properties are observed at phase transitions of the host. The observed optical transitions are assigned to the specific energy states of Bi+ ion. It is shown that two thermalized levels are responsible for the luminescence. The experimental temperature behavior of the emission and excitation bands are in agreement with theory of electron-phonon interaction of impurity centers in solids; the effective-phonon frequencies and Huang-Rhys parameters are estimated. The configuration coordinate diagram is determined for the Bi+ center in KAlCl4 crystal.

  14. FAMENNIAN CONODONTS FROM KAL-E-SARDAR SECTION, EASTERN TABAS, CENTRAL IRAN

    Directory of Open Access Journals (Sweden)

    HOSSEIN GHOLAMALIAN

    2009-07-01

    Full Text Available Sixty-three conodont species and subspecies from the Kal-e-Sardar section indicate that the strata span early to late Famennian. Contrary to most of the sections measured in the Shishtu Formation, the icriodid-polygnathid biofacies is restricted to the lower part of Kal-e-Sardar Famennian succession. Palmatolepid and bispathodid-dominated  biofacies in the middle and upper part of section represent a deep shelf to mid-continental slope marine environment. The currently accepted ranges of P. tichonovitchi, P. tenellus and P. inconcinnus are early Famennian, late Frasnian-early Famennian, and early to middle Famennian, respectively, together with middle to late Famennian for P. nodoundatus. Two new species, Polygnathus sardarensis and P. yazdii, are proposed. 

  15. Decreased expression of Kallmann syndrome 1 sequence gene (KAL1) contributes to oral squamous cell carcinoma progression and significantly correlates with poorly differentiated grade.

    Science.gov (United States)

    Liu, Jiannan; Cao, Wei; Chen, Wantao; Xu, Liqun; Zhang, Chenping

    2015-02-01

    Kallmann syndrome 1 sequence gene (KAL1) protein is an extracellular matrix associated protein which plays vital roles in neurons development and cell migration. However, its biological functions and clinical implications have yet not been revealed in oral carcinogenesis. The objective of the study was to evaluate the role of KAL1 in oral cancer and determine clinical significance of KAL1 in oral squamous cell carcinomas (OSCCs). The expression pattern of KAL1 was examined in a testing cohort including OSCCs (n = 42) and paired adjacent tissues (PATs) (n = 14) by real-time PCR. The result was further validated in a validating cohort of OSCCs (n = 32). Correlation between clinicopathological parameters and KAL1 mRNA levels was analyzed by Kruskal-Wallis test. In vitro, the effects of KAL1 ablation through siRNA-mediated knockdown on the proliferation of OSCC cells were determined by CCK-8, BrdU, and colonies formation assays, respectively. In addition, cell cycle distribution was further evaluated by cytometry. We observed that remarkably decreased expression of KAL1 mRNA in two independent cohorts (P = 0.0002 and P = 0.033, respectively). Furthermore, downregulated KAL1 mRNA was significantly associated with worse pathological grade (P = 0.013 and P = 0.035, respectively). Upon KAL1 silencing, the proliferation and colonies formation potentials of OSCC cells were notably promoted by accelerating G1 to M phase transition. These data indicated that KAL1 plays a potential suppressive role on OSCC initiation and progression, and KAL1 gene may serve as an adjuvant biomarker for the identification of pathological grade. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  16. Terrorism and the Crash of KAL Flight 858: A Comparison of U.S. and South Korean Newspaper Coverage.

    Science.gov (United States)

    Salwen, Michael B.; Lee, Jung-Sook

    A case study compared United States and South Korean press coverage of the crash of the November 29, 1987, Korean Air Lines (KAL) flight 858, to examine how the press reported the terrorism angle before evidence supporting the charges of terrorism was uncovered. Stories dealing with the crash reported in four prestigious United States newspapers…

  17. Clinical assessment and molecular analysis of GnRHR and KAL1 genes in males with idiopathic hypogonadotrophic hypogonadism.

    Science.gov (United States)

    Versiani, Beatriz R; Trarbach, Ericka; Koenigkam-Santos, Marcel; Dos Santos, Antonio Carlos; Elias, Lucila L K; Moreira, Ayrton C; Latronico, Ana Claudia; de Castro, Margaret

    2007-02-01

    The pathogenesis of idiopathic hypogonadotrophic hypogonadism (IHH) is mostly unclear. We characterized the clinical findings and molecular analysis of GnRHR and KAL1 genes in 26 Brazilian males with IHH with and without hyposmia/anosmia. Design Clinical assessment was performed for endocrine status, olfactory structure and function, renal lesion, and mirror movement. The diagnosis of Kallmann syndrome (KS) included HH and the clinical complaint of hyposmia/anosmia or decreased olfactory acuity obtained by the Smell Identification Test (SIT). We analysed GnRHR and KAL1 genes using the polymerase chain reaction (PCR) direct sequencing method. A variable degree of HH was observed, including various clinical abnormalities, such as cryptorchidism, hearing loss, strabismus, cleft lip/palate, high-arched palate, dental agenesis, psychiatric disorders, learning dysfunction, and bimanual synkinesia. Twenty-two out of 26 patients with IHH (85%) were classified as KS. Abnormalities of olfactory bulbs/sulci were observed in 79% of KS patients. One-third of KS patients had renal defects and 45.5% had a positive family history. GnRHR gene sequence analysis showed no mutations. KAL1 sequence analysis identified two novel missense mutations: c.1061A to G in exon 7 (N304S) and c.1583C to A in exon 10 (S478X). We also observed a 14-bp deletion within exon 11 that caused a premature termination. According to the National Center for Biotechnology Information (NCBI)-Single Nucleotide Polymorphism (SNP) database, two previously described polymorphisms (rs808119 and rs809446) were detected. KAL1 mutations accounted for 12% of KS patients. This low prevalence of KAL1 mutations indicates that other genes, such as the fibroblast growth factor receptor 1 (FGFR1) gene or other as yet undiscovered genes, epigenetic events and/or environmental factors might be involved in the aetiology and phenotypic variability of KS.

  18. The variational iteration method and the variational homotopy perturbation method for solving the KdV-Burgers equation and the Sharma-Tasso-Olver equation

    Energy Technology Data Exchange (ETDEWEB)

    Zayed, Elsayed M.E. [Dept. of Mathematics, Zagazig Univ. (Egypt); Abdel Rahman, Hanan M. [Dept. of Basic Sciences, Higher Technological Inst., Tenth of Ramadan City (Egypt)

    2010-01-15

    In this article, two powerful analytical methods called the variational iteration method (VIM) and the variational homotopy perturbation method (VHPM) are introduced to obtain the exact and the numerical solutions of the (2+1)-dimensional Korteweg-de Vries-Burgers (KdVB) equation and the (1+1)-dimensional Sharma-Tasso-Olver equation. The main objective of the present article is to propose alternative methods of solutions, which avoid linearization and physical unrealistic assumptions. The results show that these methods are very efficient, convenient and can be applied to a large class of nonlinear problems. (orig.)

  19. Intrauterin Beslenme Durumunun Değerlendirilmesinde Fetal ve Neonatal Antropometrik Ölçümler ve Skinfold Kalınlıkları

    OpenAIRE

    Tunç, Bahattin; Kaya, Hakan; Çalışkan, Sadettin; Öztan, Mediha

    2009-01-01

    Intrauterin Beslenme Durumunun Değerlendirilmesinde Fetal ve Neonatal Antropometrik Ölçümler ve Skinfold Kalınlıkları Bahattin Tunç, Hakan Kaya, Sadettin Çalışkan Mediha Öztan Özet Sağlıklı 29 gebenin normal vajinal yolla dünyaya gelen 29 yenidoğan bebeğinde fetal ve neonatal antropometrik ölçümler yapıldı. Antropometrik değerler neonatal skinfold kalınlıkları ile karşılaştırıldı. Anne skinfold kalınlıkları ile bebeğin skinfold kalınlıkları arasında bir korelasyon yoktu. Beb...

  20. First-principles determination of the K-conductivity pathways in KAlO2

    KAUST Repository

    Peskov, Maxim

    2015-04-30

    Investigation of novel fast ion-conducting materials requires an accurate description of the ionic diffusion. The tiling method proposed by Blatov and coworkers, based on geometric characteristics, is a viable alternative to molecular dynamics simulations, allowing us to build models of the pathway system in crystal structures; however, the reliability is limited. Using first-principles simulations, we calculate the potential barriers of the ionic migration between voids in the structure of KAlO2 with local framework distortions and compare the results with those of the tiling method. We estimate the potential barriers for complex ion-conducting channels including several hopping distances. The effect of Coulomb interaction between charge carriers located in adjacent pathways on the potential barriers is discussed, and the effects of the framework flexibility are analyzed. Quantitative results on the potential barriers of ionic diffusion in a crystal structure and its dependence on the shape of the channels are important for assessing the potential of a specific compound. © 2015 American Chemical Society.

  1. Hollandite II phase in KAlSi 3O 8 as a potential host mineral of potassium in the Earth's lower mantle

    Science.gov (United States)

    Hirao, Naohisa; Ohtani, Eiji; Kondo, Tadashi; Sakai, Takeshi; Kikegawa, Takumi

    2008-01-01

    High-pressure and high-temperature experiments on the KAlSi 3O 8 composition were conducted in a laser-heated diamond-anvil cell at pressures up to 128 GPa, which correspond to the lowermost mantle conditions. In situ synchrotron X-ray diffraction measurements revealed that the hollandite II phase in KAlSi 3O 8 with a monoclinic symmetry of I2/ m was stable over the entire range of mantle conditions, and the tunnel structure formed by the double chains of edge-sharing (Si,Al)O 6 octahedra, which could accommodate a larger cation such as potassium, was sustained. The (Si,Al)O 6 octahedra in the KAlSi 3O 8 hollandite II phase showed a similar compression behavior to those in high-pressure silicate structures, such as rutile-type and perovskite-type phases, and were found to be less compressible than the KO 8 polyhedra. The KAlSi 3O 8 hollandite II phase is a potential host mineral for potassium under lower mantle conditions and, therefore, may have a significant influence on geochemistry if potassium feldspar KAlSi 3O 8 in the Earth's crust is transported into the Earth's mantle through subduction.

  2. Neurexin-Neuroligin Synaptic Complex Regulates Schizophrenia-Related DISC1/Kal-7/Rac1 “Signalosome”

    DEFF Research Database (Denmark)

    Jacobsen, Sylwia Owczarek; Bang, Marie Louise; Berezin, Vladimir

    2015-01-01

    Neurexins (NXs) and neuroligins (NLs) are cell adhesion molecules that are localized at opposite sites of synaptic membranes. They interact with each other to promote the assembly, maintenance, and function of synapses in the central nervous system. Both NX and NL are cleaved from a membrane...... downstream of DISC1. We also show that NL1 binds to a well-characterized DISC1 interaction partner, Kal-7, and this interaction can be compromised by DISC1. Our results indicate that the NX/NL synaptic complex is intrinsically involved in the regulation of DISC1 function, thus contributing to a better...

  3. Mito e realtà della letteratura ebraica al femminile in Germania: Anna Seghers e Mascha Kaléko

    Directory of Open Access Journals (Sweden)

    Karin Birge Gilardoni-Büch

    2014-04-01

    Both of them succeed in emigrating and surviving the destruction of the European Jews. Anna Seghers comes back in 1947 to the Soviet occupied zone and will later hold significant offices inside East Germany's cultural life. Mascha Kaléko will however come back only now and then to the German Federal Republic. Did their writing change after the Shoah? And if so, to what extent? Moreover, do the texts mirror the situation in which their authors found themselves? Aren’t they linked to a specific social condition, that of a woman? To what extent do specific female and Jewish experiences take shape in their works?

  4. Clinical characteristics and follow-up of 5 young Chinese males with gonadotropin-releasing hormone deficiency caused by mutations in the KAL1 gene

    Directory of Open Access Journals (Sweden)

    Juan Li

    2016-02-01

    Full Text Available Isolated gonadotropin-releasing hormone (GnRH deficiency (IGD pertains to a group of genetic disorders consisting of anosmic hypogonadotropic hypogonadism (Kallmann syndrome, KS and normosmic idiopathic hypogonadotropic hypogonadism (nIHH. KS is genetically heterogeneous. We hereby present 5 young male patients with GnRH deficiency caused by mutations in the KAL1 gene. Their ages ranged from 9 months to 16 years. They were referred to our department for an endocrine consultation for micropenis. Hormone assays showed low circulating gonadotropins and testosterone. Molecular studies revealed KAL1 mutations in all cases, three reported nonsense sequence variants in the KAL1 gene were detected in 4 patients, respectively (c.784C > T (p.Arg 262*, c.1267C > T (p.Arg423*, and c.1270C > T (p.Arg424*, and one patient harbored a novel hemizygous sequence variant [c.227G > A (p.Trp76*]. Only one patient presented short stature without growth hormone deficiency and anosmia. Another patient had bilateral eyelid ptosis, trichiasis, and refractive error. This is the first report on the co-occurrence of a KAL1 gene mutation and tent-like upper lip in four patients. All of our cases had normal olfactory bulbs and showed no renal agenesis, cleft lip/palate, and hearing impairment. These cases expand our knowledge of the phenotype associated with KAL1 sequence variations, although the precise mechanism by which KAL1 gene influences the development of this phenotype is still unknown.

  5. X chromosome-linked Kallmann syndrome: clinical heterogeneity in three siblings carrying an intragenic deletion of the KAL-1 gene.

    Science.gov (United States)

    Massin, Nathalie; Pêcheux, Christophe; Eloit, Corinne; Bensimon, Jean-Louis; Galey, Julie; Kuttenn, Frédérique; Hardelin, Jean-Pierre; Dodé, Catherine; Touraine, Philippe

    2003-05-01

    Kallmann syndrome (KS) is characterized by the association of hypogonadotropic hypogonadism and anosmia. The gene underlying the X chromosome-linked form of the disease, KAL-1, consists of 14 coding exons. It encodes a glycoprotein, anosmin-1, which is involved in the embryonic migration of GnRH-synthesizing neurons and the differentiation of the olfactory bulbs. We describe herein the clinical heterogeneity in three affected brothers who carry a large deletion (exons 3-13) in KAL-1. All three had a history of hypogonadotropic hypogonadism with delayed puberty. Although brain magnetic resonance imaging showed hypoplastic olfactory bulbs in the three siblings, variable degrees of anosmia/hyposmia were shown by olfactometry. In addition, these brothers had different phenotypic anomalies, i.e. unilateral renal aplasia (siblings B and C), high-arched palate (sibling A), brachymetacarpia (sibling A), mirror movements (siblings A and B), and abnormal eye movements (sibling C). Last but not least, sibling A suffered from a severe congenital hearing impairment, a feature that had been reported in KS but had not yet been ascribed unambiguously to the X-linked form of the disease. The variable phenotype, both qualitatively and quantitatively, in this family further emphasizes the role of putative modifier genes, and/or epigenetic factors, in the expressivity of the X-linked KS.

  6. Novel application of luciferase assay for the in vitro functional assessment of KAL1 variants in three females with septo-optic dysplasia (SOD)

    Science.gov (United States)

    McCabe, Mark J.; Hu, Youli; Gregory, Louise C.; Gaston-Massuet, Carles; Alatzoglou, Kyriaki S.; Saldanha, José W.; Gualtieri, Angelica; Thankamony, Ajay; Hughes, Ieuan; Townshend, Sharron; Martinez-Barbera, Juan-Pedro; Bouloux, Pierre-Marc; Dattani, Mehul T.

    2015-01-01

    KAL1 is implicated in 5% of Kallmann syndrome cases, a disorder which genotypically overlaps with septo-optic dysplasia (SOD). To date, a reporter-based assay to assess the functional consequences of KAL1 mutations is lacking. We aimed to develop a luciferase assay for novel application to functional assessment of rare KAL1 mutations detected in a screen of 422 patients with SOD. Quantitative analysis was performed using L6-myoblasts stably expressing FGFR1, transfected with a luciferase-reporter vector containing elements of the FGF-responsive osteocalcin promoter. The two variants assayed [p.K185N, p.P291T], were detected in three females with SOD (presenting with optic nerve hypoplasia, midline and pituitary defects). Our novel assay revealed significant decreases in transcriptional activity [p.K185N: 21% (p < 0.01); p.P291T: 40% (p < 0.001)]. Our luciferase-reporter assay, developed for assessment of KAL1 mutations, determined that two variants in females with hypopituitarism/SOD are loss-of-function; demonstrating that this assay is suitable for quantitative assessment of mutations in this gene. PMID:26375424

  7. Comment on “An algorithm for identification and classification of individuals with type 1 and type 2 diabetes mellitus in a large primary care database”, written by Sharma et al

    Directory of Open Access Journals (Sweden)

    Bocquet V

    2017-01-01

    Full Text Available Valéry Bocquet Competence Center for Methodology and Statistics, Luxembourg Institute of Health, LuxembourgDiabetes is a disease whose global prevalence has been rising year after year, and by 2014 more than 400 million individuals were diagnosed with diabetes.1 As a consequence, screening of patients with type 1 or type 2 diabetes has become important, both to estimate the prevalence of diabetes and to treat affected individuals. For that purpose, a two-step algorithm suggested by Sharma et al2 was recently published, whose aims were to identify type 1 or type 2 individuals from a primary care database. The first step of the algorithm was based on the diagnostic records, treatment given, and results obtained from clinical tests. The second part was based on the combination of diagnostic codes, prescribed medications, age at the time of diagnosis, and finally whether the case was prevalent or incident.View original paper by Sharma et al

  8. Plastik Enjeksiyon Kalıpları İçin Bilgisayar Destekli Soğutma Sistemi Tasarımı

    Directory of Open Access Journals (Sweden)

    Hakan GÜRÜN

    2009-02-01

    Full Text Available Plastik enjeksiyon kalıplarının ve soğutma sisteminin tasarımı, hem ürünün boyut, biçim ve kalitesini, hem de çevrim zamanını ve kalıbın maliyetini doğrudan etkilemektedir. Yapılan çalışmada, plastik enjeksiyon kalıplarının ve soğutma sisteminin katı model olarak tasarımı, mümkün olduğu kadar kullanıcı etkileşiminden uzak olarak gerçekleştirilmiştir. Hazırlanan program, kalıp çekirdeklerinin üç farklı tipte soğutma sistemine, farklı göz yerleşimlerine ve parça sayılarına bağlı olarak tasarımının yapılmasına izin vermektedir. Program akışında, AutoCAD 2007 paket programının yanında Visual LISP ve VBA (Visual BASIC for Application dilleri de kullanılmıştır. Çalışma kapsamında yürütülen deneme uygulamaları ile plastik enjeksiyon kalıplarının tasarımında hız, esneklik ve tasarım güvenilirliğinin arttığı tespit edilmiştir.

  9. Five new species of freshwater crabs of the genera Ghatiana Pati & Sharma, 2014, and Gubernatoriana Bott, 1970 (Crustacea, Decapoda, Brachyura: Gecarcinucidae Rathbun, 1904) from the Western Ghats, India.

    Science.gov (United States)

    Pati, S K; Thackeray, T; Khaire, A

    2016-02-23

    Five new species of gecarcinucid freshwater crabs, Ghatiana atropurpurea n. sp., Ghatiana splendida n. sp., Gubernatoriana alcocki Pati n. sp., Gubernatoriana thackerayi Pati n. sp., and Gubernatoriana waghi Pati n. sp. are described from the Western Ghats in Maharashtra and Goa states of India. Ghatiana atropurpurea n. sp. can be differentiated from other species of Ghatiana Pati & Sharma, 2014 by the shape and colour of its carapace, and the sigmoid-shaped male first pleopod (G1). Ghatiana splendida n. sp. is separated from its congeners mainly by its long anterolateral margin of the carapace and short terminal article of the G1. Besides, the colour pattern (deep pink carapace and chelipeds, orange ambulatory legs) of G. splendida n. sp. is exceptional among its congeners. Gubernatoriana alcocki n. sp. is unique among species of Gubernatoriana Bott, 1970 due to its inwardly curved tip of the terminal article of the G1. The stout and cone-shaped terminal article of the G1 of G. thackerayi n. sp. is characteristic among its congeners. In addition, G. thackerayi n. sp. has a unique colouration amongst congeners (violet-red carapace and ambulatory legs, orange-red chelipeds). Gubernatoriana waghi n. sp. can be distinguished from its congeners by the quadrate-shaped carapace, narrow frontal margin, pointed tips of the cheliped fingers, short terminal article of the G1 and very short or vestigial terminal article of the male second pleopod (G2). The body colour (burnt orange carapace and ivory coloured chelipeds and ambulatory legs) of G. waghi n. sp. is also important to distinguish live crabs of the genus. Key to the species of Ghatiana and Gubernatoriana is provided.

  10. 特发性低促性腺激素型性腺功能减退患者KAL1基因突变分析%Mutation of the KAL1 gene in 30 male patients with idiopathic hypogonadotropic hypogonadism

    Institute of Scientific and Technical Information of China (English)

    马超; 蒋召志; 李学付; 云馨; 付超; 刘睿智

    2011-01-01

    Objective: To analyze the mutation of the KAL1 gene in male patients with idiopathic hypogonadotropic hypogonadism (IHH). Methods: We analyzed the exon mutation of the KAL1 gene in 30 IHH patients using polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) combined with the PCR product direct sequencing technique. Results:Three cases of the KAL1 gene mutation were found among the total number of patients, including 1 case of nonsense mutation ( c. 1270C >T,p. R424X), and 2 cases of frameshift mutation, (c. 279_280delAG,p. G94fs) and (c. 1886_1887delTT,p. L629fs). Conclusion: Of the 3 cases of the KAL1 gene mutation we detected, 2 are new and 1 already reported in the literature. The results of our study have provided valuable information on the molecular genetics of the IHH syndrome.%目的:分析男性特发性低促性腺激素型性腺功能减退(IHH)患者KAL1基因突变. 方法:30例IHH患者运用聚合酶链反应-单链构象多态性(PCR-SSCP)结合PCR产物直接测序技术分析KAL1基因外显子突变. 结果:在30例IHH患者中共发现3例KAL1基因突变,其中1例无义突变,为(c.1270C>T,p.R424X);2例移码突变,分别为(c.279_280delAG,p.G94fs)和(c.1886_1887delTr,p.L629fs). 结论:本文检测到3例KAL1基因突变,其中2例突变是新发现的突变,1例是文献报道过的突变,为IHH的分子遗传学研究积累了宝贵资料.

  11. Taxonomy of two endemic Indian skinks, Eutropis bibronii (Gray, 1838)and E. nagarjunensis (Sharma, 1969) (Reptilia: Scincidae), including redescriptions of their types.

    Science.gov (United States)

    Amarasinghe, A A Thasun; Campbell, Patrick D; Chandramouli, S R; Deuti, Kaushik; Raha, Sujoy; Karunarathna, D M S Suranjan; Ineich, Ivan

    2016-08-19

    Tiliqua bibronii was described by J.E. Gray in December, 1838 based on two syntypes (MNHN-RA 2940, 7076), but the details for locality was missing. These syntypes are currently housed at the Muséum national d'Histoire naturelle, Paris, France (MNHN-RA). The same species (based on the same type specimens) was described by A.M.C. Duméril & G. Bibron in November, 1839 nearly one year after Gray's publication. As such, Gray's publication must therefore be given priority. Another species, Euprepis trilineatus, from Madras, Tamil Nadu, India, was described by Gray in 1846, and it is morphologically similar to E. bibronii. Later, Boulenger (1885) synonymised it with E. bibronii. Eutropis bibronii has subsequently been recorded from other parts of India and Sri Lanka by various authors. Many years later, a closely related species, Mabuya nagarjuni (sic) Sharma, 1969, was described from Andhra Pradesh, India, based on two specimens (a holotype and a paratype) housed at the Zoological Survey of India, Kolkata (ZSI). Here we make a correction for the species epithet as "nagarjunensis" which should be a toponym, not a patronym. Among the skink collections at the Natural History Museum, London (BMNH), ZSI, and MNHN-RA we found E. bibronii specimens collected from various locations in India, but we were unable to find any specimens from Sri Lanka. Based on morphological evidence, E. bibronii represents a single, fairly widespread, species which has to be considered endemic to India. Although, recent phylogenetic studies reveal a distinct genetic divergence between E. bibronii and E. nagarjunensis, both species are morphologically very similar to each other. Here, we examine the morphology of E. nagarjunensis based on the ZSI specimens. A comprehensive comparison between the syntypes of E. bibronii and Euprepis trilineatus confirms that the latter nomen is a junior synonym of the former. The original description of E. bibronii is extremely concise and lacks most of the

  12. Aspects of stability of K/Al2O3 catalysts for the transesterification of rapeseed oil in batch and fixed-bed reactors

    Institute of Scientific and Technical Information of China (English)

    Petr Kutálek; Libor Čapek; Lucie Smoláková; David Kubička; Martin Hájek

    2014-01-01

    Catalytically active, stable, and mechanically durable solid K/Al2O3 catalysts for the transesterifica-tion of rapeseed oil with methanol was studied. In a batch reactor, high catalytic activity was ac-companied by leaching of K species, caused by glycerol, and mechanical destruction of the solid catalyst as a result of contact with the stirrer. In a fixed-bed reactor, some leaching of K species into the liquid phases was also observed, but approached 0 during 30 h of time-on-stream; the activity of the K/Al2O3 catalyst (~83% ester yield) was stable for 100 h of time-on-stream and no mechanical destruction of the catalyst was observed. The populations of K2O and K-O-Al species for fresh and used K/Al2O3 catalysts were compared using Fourier transform infrared spectroscopy. It was found that some K2O species leached into the liquid phases at the beginning of the reaction.

  13. Unravelling regolith material types using Mg/Al and K/Al plot to support field regolith identification in the savannah regions of NW Ghana, West Africa

    Science.gov (United States)

    Arhin, Emmanuel; Zango, Saeed M.

    2015-12-01

    The XRF analytical method was used to measure the weight % of the major oxides in regolith samples. The metal weight % of Mg, K and Al were calculated from their oxides and were normalised relative to immobile Al calculated from its oxide. The plot of Mg/Al and K/Al identified the regolith of the study area to consist of 137 transported clays, 4 ferruginous sediments or ferricrete, 2 lateritic duricrust and 4 saprolites. Surface regolith that had undergone secondary transformation and shows compositional overlaps were 4 transported clays with Fe-oxide impregnation may be referred to as nodular laterite and 5 ferruginous saprolites. The variable regolith materials features identified from the 154 samples enabled the characterisation and identification of the different sample materials because an overprint of bedrock geochemistry is reflected in the regolith. Plot of Mg/Al and K/Al highlighted the compositional variability of the regolith samples and refute the notion of the homogeneity of all the sampled materials in the area. The study thus recognized Mg/Al versus K/Al plots to be used in supporting field identification of regolith mapping units particularly in complex regolith terrains of savannah regions of Ghana and in similar areas where geochemical exploration surveys are being carried out under cover.

  14. The Adhesion Molecule KAL-1/anosmin-1 Regulates Neurite Branching through a SAX-7/L1CAM–EGL-15/FGFR Receptor Complex

    Directory of Open Access Journals (Sweden)

    Carlos A. Díaz-Balzac

    2015-06-01

    Full Text Available Neurite branching is essential for correct assembly of neural circuits, yet it remains a poorly understood process. For example, the neural cell adhesion molecule KAL-1/anosmin-1, which is mutated in Kallmann syndrome, regulates neurite branching through mechanisms largely unknown. Here, we show that KAL-1/anosmin-1 mediates neurite branching as an autocrine co-factor with EGL-17/FGF through a receptor complex consisting of the conserved cell adhesion molecule SAX-7/L1CAM and the fibroblast growth factor receptor EGL-15/FGFR. This protein complex, which appears conserved in humans, requires the immunoglobulin (Ig domains of SAX-7/L1CAM and the FN(III domains of KAL-1/anosmin-1 for formation in vitro as well as function in vivo. The kinase domain of the EGL-15/FGFR is required for branching, and genetic evidence suggests that ras-mediated signaling downstream of EGL-15/FGFR is necessary to effect branching. Our studies establish a molecular pathway that regulates neurite branching during development of the nervous system.

  15. Neurexin-Neuroligin Synaptic Complex Regulates Schizophrenia-Related DISC1/Kal-7/Rac1 “Signalosome”

    Directory of Open Access Journals (Sweden)

    Sylwia Owczarek

    2015-01-01

    Full Text Available Neurexins (NXs and neuroligins (NLs are cell adhesion molecules that are localized at opposite sites of synaptic membranes. They interact with each other to promote the assembly, maintenance, and function of synapses in the central nervous system. Both NX and NL are cleaved from a membrane-attached intracellular domain in an activity-dependent manner, generating the soluble ectodomain of NX or NL. Expression of the NX1 and NX3 genes in the brain appears to be regulated by a schizophrenia-related protein, DISC1. Here, we show that soluble ecto-NX1β can regulate the expression of DISC1 and induce signaling downstream of DISC1. We also show that NL1 binds to a well-characterized DISC1 interaction partner, Kal-7, and this interaction can be compromised by DISC1. Our results indicate that the NX/NL synaptic complex is intrinsically involved in the regulation of DISC1 function, thus contributing to a better understanding of the pathology of schizophrenia.

  16. CaCl2对KAlSi3O8-CaSO4-CaCO3反应体系的影响研究%THE INFLUENCE OF CaCl2 AGENT ADDITION ON THE KAlSi3O8-CaSO4-CaCO3 SYSTEM

    Institute of Scientific and Technical Information of China (English)

    石林; 曾小平; 罗汉金

    2010-01-01

    通过CaCl2添加剂对KAlSi3O8-CaSO4-CaCO3体系研究反应温度和反应时间的影响研究,结果表明:随着CaCl2加入量的增多,体系的反应温度下降,反应时间缩短,当CaCl2的加入量为10%时,反应温度可降至1 000℃,反应时问降至25 min,此时KAlSi3O8的转化率仍可高达83.24%.研究CaCl2的加入对KAlSi3O8-CaSO4-CaCO3反应体系动力学过程的影响,得出反应体系符合金斯特林格动力学方程:FK(G)=1-2/3G-(1-G) 2/3=KKt,反应受扩散过程控制,计算出当CaCl2的加入量为10%时,体系的表观活化能可从原来的128.921 kJ/mol下降至58.320 kJ/mol.

  17. In-Situ Studies of Structure Transformation and Al Coordination of KAl(MoO42 during Heating by High Temperature Raman and 27Al NMR Spectroscopies

    Directory of Open Access Journals (Sweden)

    Min Wang

    2017-03-01

    Full Text Available Recent interest in optimizing composition and synthesis conditions of functional crystals, and the further exploration of new possible candidates for tunable solid-state lasers, has led to significant research on compounds in this family MIMIII(MVIO42 (MI = alkali metal, MIII = Al, In, Sc, Fe, Bi, lanthanide; MVI = Mo, W. The vibrational modes, structure transformation, and Al coordination of crystalline, glassy, and molten states of KAl(MoO42 have been investigated by in-situ high temperature Raman scattering and 27Al magic angle spinning nuclear magnetic resonance (MAS NMR spectroscopy, together with first principles density functional simulation of room temperature Raman spectrum. The results showed that, under the present fast quenching conditions, Al is present predominantly in [AlO6] octahedra in both KAl(MoO42 glass and melt, with the tetrahedrally coordinated Al being minor at approximately 2.7%. The effect of K+, from ordered arrangement in the crystal to random distribution in the melt, on the local chemical environment of Al, was also revealed. The distribution and quantitative analysis of different Al coordination subspecies are final discussed and found to be dependent on the thermal history of the glass samples.

  18. KAL8 METAR

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — METAR is a routine scheduled observation and is the primary observation code used in the United States to satisfy requirements for reporting surface meteorological...

  19. ESTUDIO DEL CATALIZADOR K/Al2O3 OPERANDO EN FORMA DE SUSPENSIÓN Y AGITADOR MONOLITICO EN LA TRANSESTERIFICACIÓN DE TRIGLICÉRIDOS

    OpenAIRE

    2011-01-01

    En este trabajo se preparó y caracterizó el catalizador K/Al2O3 y el correspondiente catalizador monolito. Las muestras fueron estudiadas en la transesterificación de aceite de soja con metanol a 60 °C, con una relación molar alcohol:aceite = 30, y una carga de catalizador de 1% para estudios de catalizadores en polvo y de 0,5% en el caso del monolito. El catalizador en polvo reportó un rendimiento de FAME (ésteres metílicos de ácidos grasos) de 73,0 y 64,0% para el primer y segundo uso respe...

  20. Potential for high thermoelectric performance in n-type Zintl compounds: a case study of Ba doped KAlSb 4

    Energy Technology Data Exchange (ETDEWEB)

    Ortiz, Brenden R.; Gorai, Prashun; Krishna, Lakshmi; Mow, Rachel; Lopez, Armando; McKinney, Robert; Stevanović, Vladan; Toberer, Eric S.

    2017-01-01

    High-throughput calculations (first-principles density functional theory and semi-empirical transport models) have the potential to guide the discovery of new thermoelectric materials. Herein we have computationally assessed the potential for thermoelectric performance of 145 complex Zintl pnictides. Of the 145 Zintl compounds assessed, 17% show promising n-type transport properties, compared with only 6% showing promising p-type transport. We predict that n-type Zintl compounds should exhibit high mobility un while maintaining the low thermal conductivity KL typical of Zintl phases. Thus, not only do candidate n-type Zintls outnumber their p-type counterparts, but they may also exhibit improved thermoelectric performance. From the computational search, we have selected n-type KAlSb4 as a promising thermoelectric material. Synthesis and characterization of polycrystalline KAlSb4 reveals non-degenerate n-type transport. With Ba substitution, the carrier concentration is tuned between 1018 and 1019 e- cm-3 with a maximum Ba solubility of 0.7% on the K site. High temperature transport measurements confirm a high un (50 cm2 V-1 s-1) coupled with a near minimum KL (0.5 W m-1 K-1) at 370 degrees C. Together, these properties yield a zT of 0.7 at 370 degrees C for the composition K0.99Ba0.01AlSb4. Based on the theoretical predictions and subsequent experimental validation, we find significant motivation for the exploration of n-type thermoelectric performance in other Zintl pnictides.

  1. Children with idiopathic hypogonadotropic hypogonadism: clinical data analysis and mutations analysis of KAL1 and FGFR1 gene%特发性低促性腺激素性性腺功能减退症临床特点及KAL1与FGFR1基因突变分析

    Institute of Scientific and Technical Information of China (English)

    秦淼; 巩纯秀; 齐展; 吴迪; 刘敏; 谷奕; 曹冰燕; 李文京; 梁学军

    2014-01-01

    Objective To summarize the clinical features of idiopathic hypogonadotropic hypogonadism(IHH) diagnosed during childhood,and detect mutations in KAL1 and FGFR1,acting as key clues for diagnoses.Method We collected and analyzed clinical data of 21 cases (including demographic data,chief complaint,history of present illness,family history,physical examination,laboratory tests and imaging studies,etc.) diagnosed with IHH from December 2008 to February 2013.Polymerase chain reaction and gene sequencing was applied to detect mutations on KAL1 and FGFR1.Fifty healthy unrelated individuals were choosen as controls.Result Of 21 patients with IHH,19 were males and 2 females,they visited us initially from 8-17 years old,with an average of (13.58 ± 2.38)years old.Sixteen cases were KS patients(76%).One boy reported abnormal sense of smelling but having olfactory perfect picture on MRI;2/19 male cases had no puberty when they were over 13-14 years old without abnormal external genitalia.8/19 cases only had small penis,8/19 had both of cryptorchidism and small penis,and the Case 2 also had hypospadias.One boy had cryptorchidism combined with a normal penis.Only 2 girls diagnosed as IHH who visited us because of no puberty signs when they were 13 and 16 years old,respectively.Other clinical manifestations included:one with gynecomastia,2 had mental retardation,and one was deaf; one with high palatal arch; one with mirror-movement and one with left renal agenesis but normal renal function respectively.Laboratory tests showed that the basic testosterone (T) is low and with inappropriately low or normal gonadotropin hormones.The results of cases of standard human chorionic gonadotropin(HCG) test of 7cases out of 19 male children's were normal (testosterone > 1 100 ng/L),and another nine cases continued to complete the extended HCG test,and the testosterone levels of two of them (cases 6,8) were still lower than 1 000 ng/L.Family history:the parents in 9/21 family had delayed

  2. Spectral Psychoanalysis of Speech under Strain | Sharma ...

    African Journals Online (AJOL)

    Spectral Psychoanalysis of Speech under Strain. ... Different voice features from the speech signal to be influenced by strain are: loudness, fundamental frequency, jitter, zero-crossing rate, ... EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT

  3. 632-IJBCS-Article-Shrinivas Sharma

    African Journals Online (AJOL)

    DR GATSING

    1998). PON1 hydrolyzing activity of some activated phospholipids (Watson et al., 1995) and lipid peroxide ... antioxidants preserve serum PON1 level. (Aviram et al. .... was enhanced by glycerol molecules ..... lipid peroxide in animal tissue by.

  4. First-principles prediction of fast migration channels of potassium ions in KAlSi3O8 hollandite: Implications for high conductivity anomalies in subduction zones

    Science.gov (United States)

    He, Yu; Sun, Yang; Lu, Xia; Gao, Jian; Li, Hong; Li, Heping

    2016-06-01

    Materials sharing the hollandite structure were widely reported as fast ionic conductors. However, the ionic conductivity of KAlSi3O8 hollandite (K-hollandite), which can be formed during the subduction process, has not been investigated so far. Here first-principles calculations are used to investigate the potassium ion (K+) transport properties in K-hollandite. The calculated K+ migration barrier energy is 0.44 eV at a pressure of 10 GPa, an energy quite small to block the K+ migration in K-hollandite channels. The calculated ionic conductivity of K-hollandite is highly anisotropic and depends on its concentration of K+ vacancies. About 6% K+ vacancies in K-hollandite can lead to a higher conductivity compared to the conductivity of hydrated wadsleyite and ringwoodite in the mantle. K+ vacancies being commonly found in many K-hollandite samples with maximum vacancies over 30%, the formation of K-hollandite during subduction of continental or alkali-rich oceanic crust can contribute to the high conductivity anomalies observed in subduction zones.

  5. Conditions écophysiologiques de la survie dans la glace des oeufs de corégones du lac Baïkal

    Directory of Open Access Journals (Sweden)

    TCHERNIAEV G. A.

    1977-07-01

    Full Text Available Partant de la constatation que des œufs de corégones du lac Baïkal peuvent survivre et se développer dans la glace, l'auteur montre expérimentalement que des embryons ceillés survivent à des températures de — 4°C à condition que la vitesse de congélation soit rapide (en moins d'une heure. La température de 6°C est par contre léthale. Si la vitesse de congélation est lente (2 heures la mortalité est de 85 % à — 2°C et 98-99 % à — 4°C. L'auteur a aussi observé que le développement embryonnaire était plus rapide dans la glace du lac que dans des bouteilles de Zug en pisciculture et discute des possibilités d'action de l'énergie lumineuse.

  6. ESTUDIO DEL CATALIZADOR K/Al2O3 OPERANDO EN FORMA DE SUSPENSIÓN Y AGITADOR MONOLITICO EN LA TRANSESTERIFICACIÓN DE TRIGLICÉRIDOS

    Directory of Open Access Journals (Sweden)

    Deborath M. Reinoso

    2011-01-01

    Full Text Available En este trabajo se preparó y caracterizó el catalizador K/Al2O3 y el correspondiente catalizador monolito. Las muestras fueron estudiadas en la transesterificación de aceite de soja con metanol a 60 °C, con una relación molar alcohol:aceite = 30, y una carga de catalizador de 1% para estudios de catalizadores en polvo y de 0,5% en el caso del monolito. El catalizador en polvo reportó un rendimiento de FAME (ésteres metílicos de ácidos grasos de 73,0 y 64,0% para el primer y segundo uso respectivamente, luego de 5 hs de reacción. Comparando la muestra monolítica con el catalizador en polvo (en iguales condiciones de reacción, el rendimiento de FAME fue del 58,0% y 60,5% respectivamente. Los ensayos de lixiviación indicaron que el K se pierde en los dos primeros ensayos, permaneciendo estable durante tres ensayos más. Se deduce que las especies homogéneas generadas durante la reacción tuvieron un rol importante en la actividad.

  7. Evre IV küçük hücreli dışı akciğer kanserli hastaların sağkalımını etkileyen faktörler

    Directory of Open Access Journals (Sweden)

    Turgut Kaçan

    2013-09-01

    Full Text Available Amaç. Bu çalışmada evre IV küçük hücreli dışı akciğer kanserli hastalarda tedavi öncesi prognostik faktörlerin sağkalım üzerine etkilerinin incelenmesi amaçlandı. Yöntem. Bu çalışma 2006-2011 tarihleri arasında merkezimize tedavi edilen evre IV küçük hücreli dışı akciğer kanserli 113 hastanın dosyalarının retrospektif incelenmesi ile yapıldı. Hastalara ait demografik, klinik ve histopatolojik veriler hasta dosya ve hastane kayıtları incelenerek elde edildi. Kontrole gelmemiş hastalar sağkalım analizi için, izin alınarak kimlik sorgulama sisteminde sorgulandı. Analiz için sıklık testleri, Mann-Whitney U testi ve Kaplan-Meier analizi kullanıldı. Bulgular. Yüzü (%88 erkek, 13'ü (%12 kadın toplam 113 hastanın verisi analiz edildi. Ortanca yaş 62 (37-82 idi. Sigara kullanımı 90 (%80 hastada, aile hikayesi 27 (%24 hastada, komorbidite 40 (%35 hastada mevcuttu. Histopatolojik alt tip olarak 24 (%21 hasta epidermoid, 30 (%27 hasta adenokarsinom, 3 (%2 hasta nöroendokrin alt tipine sahipti. Ellialtı (%50 hastanın ise histopatolojik alt tipi belirlenememişti. En sık rastalanan Eastern Cooperative Oncology Group Perfromance Statusu ECOG 1 idi. En sık metastaz yerleri beyin (%35, kemik (%32, karaciğer (%21 ve karşı akciğer (%18 idi. Hastaların 83'üne (%73 kemoterapi uygulanırken 30'una (%27 destek tedavisi verildi. Analjezik kullanımı 84 (%74 hastada var iken palyatif radyoterapi 69 (%61 hastaya uygulandı. Ortanca takip 8 ay (1-47, ortanca sağkalım 8 ay idi. Bir yıllık genel sağkalım %35 olarak tespit edildi. Eastern Cooperative Oncology Group Perfromance Statusu (p<0,001, kemoterapi uygulaması (p<0,001, tedavide cisplatin (p<0,001 ve docetaxel (p=0,043 kullanımı, laktik dehidrogenaz yüksekliği (p=0,007 sağkalımı belirleyen prognostik faktörlerdi. Kemoterapi uygulaması (p<0,001 ve laktik dehidrogenaz yüksekliği (p=0,004 ise bağımsız prognostik faktörlerdi. Sonu

  8. Steklite, KAl(SO4)2: A finding at the Tolbachik Volcano, Kamchatka, Russia, validating its status as a mineral species and crystal structure

    Science.gov (United States)

    Murashko, M. N.; Pekov, I. V.; Krivovichev, S. V.; Chernyatyeva, A. P.; Yapaskurt, V. O.; Zadov, A. E.; Zelensky, M. E.

    2013-12-01

    Steklite KAl(SO4)2 has been found in sublimates of the Yadovitaya (Poisonous) fumarole at the second cinder cone of the northern breach of the Great Fissure Tolbachik Eruption, Tolbachik volcano, Kamchatka Peninsula, Russia. Steklite was approved as a valid mineral species by the Commission on New Minerals, Nomenclature, and Mineral Classification of the International Mineralogical Association on June 2, 2011 (IMA no. 2011-041). The name steklite is left for this mineral, as it was named by Chesnokov et al. (1995) for its technogenic analog from a burnt dump of coal mine no. 47 at Kopeisk, the Southern Urals, Russia. It is named after the Russian word steklo, meaning glass, in allusion to the visual similarity of its lamellae to thin glass platelets. At Tolbachik, steklite is associated with alumoklyuchevskite, langbeinite, euchlorine, fedotovite, chalcocyanite, hematite, and lyonsite. It occurs as hexagonal or irregular-shaped lamellar crystals with the major form {001} reaching 30 μm in thickness and 0.2 mm (occasionally up to 1 mm) in width. The crystals are frequently split. They are combined into openwork aggregates or thin crusts up to 1.5 × 2.5 cm in area. Steklite is transparent and colorless, with vitreous luster. The cleavage is perfect, parallel to (001). The mineral is brittle. The Mohs' hardness is 2.5. D calc is 2.797 g/cm3. Steklite is optically uniaxial, (-), ω = 1.546(2), ɛ = 1.533(3). The chemical composition (wt %, electron-microprobe data) is as follows: 0.09 Na2O, 18.12 K2O, 0.08 CaO, 0.03 MnO, 2.02 Fe2O3, 18.18 Al2O3, 61.80 SO3. The total is 100.37. The empirical formula calculated on the basis of eight O atoms is: (K0.997Na0.008Ca0.004)Σ1.009(Al0.925Fe{0.066/3+}Mg0.003Mn0.001)Σ0.995S2.01O8. Steklite is trigonal, space group P321, a = 4.7281(3), c = 7.9936(5) Å, V = 154.76(17)Å3, Z =1. The strongest reflections in the X-ray powder diffraction pattern ( d, Å- I[ hkl]) are: 8.02-34[001], 4.085-11[100], 3.649-100[011, 101], 2

  9. Resultados del estudio PROMESA I: eficacia y seguridad de la aplicación de una dieta de muy bajo aporte calórico y reeducación alimentaria posterior mediante el método PronoKal® en el tratamiento del exceso de peso

    National Research Council Canada - National Science Library

    Amparo Martínez-Riquelme; Ignacio Sajoux; Joan Fondevila

    2014-01-01

    ... con la utilización de dieta de muy bajo aporte calórico cetogénica y posterior reeducación alimentaria según el método PronoKal® en pacientes con sobrepeso y obesidad, y la seguridad durante...

  10. Karabük İçin Dış Duvar Optimum Yalıtım Kalınlığının Enerji Tasarrufu Ve Hava Kirliliğine Etkileri

    Directory of Open Access Journals (Sweden)

    Ali Etem Gürel

    2012-12-01

    Full Text Available ÖzetBina dış duvarlarında yapılacak ısı yalıtım uygulamaları, yakıt tüketimini düşürerek enerji tasarrufu sağlamanın yanında, fosil kaynaklı yakıt kullanımından kaynaklanan ve hava kirliliğine neden olan emisyonların düşürülmesinde de son derece etkilidir. Bu çalışmada Karabük’te kömür ve doğalgaz kullanımında dış duvar optimum yalıtım kalınlığı tespitinin ekonomik ve çevresel analizi yapılmıştır. Çalışmanın ekonomik boyutu, yaşam döngüsü maliyet analizine (LCCA dayanan P1-P2 yöntemi ile gerçekleştirilmiştir. Çalışmanın sonuçları, yakıt olarak kömür kullanıldığında optimum yalıtım kalınlığı ve enerji tasarrufunun sırasıyla 0.134 m ve 117.14 TL/m² olduğunu göstermiştir. Yakıt olarak doğalgaz kullanımında ise bu değerler sırasıyla 0.116 m ve 88.39 TL/m² olarak bulunmuştur. Optimum yalıtım kalınlığının hava kirliliğine olan etkileri incelendiğinde, yalıtımsız bina dış duvarında hesaplanan CO2 ve SO2 emisyonlarının yakıt tipine bağlı olarak optimum yalıtım kalınlığı noktasında %85.4’e kadar azaldığı hesaplanmıştır.AbstractHeat insulation applications carried out on external walls of building provides energy saving by decreasing fuel consumption and also quite important in decreasing emission which results from fossil-based fuel usage and causes air pollution. In this study, economic and environmental analyses were done for determination of external wall optimum thickness in using coal and natural gas usage in Karabük. Economic extent of the study was done with P1-P2 method which is based on life cycle cost analysis (LCCA. The results show that optimum insulation thickness and energy saving are 0.134 m and 117.14 TL/m² respectively when coal is used as a fuel. These values are 0.116 m and 88.39 TL/m² when natural gas is used as fuel. When the effects of optimum insulation thickness on air pollution are observed, CO2

  11. Enabling the Kaleidoscope : Blurring Sexual Aim and Destination in James Baldwin’s Another Country Donner corps au kaléidoscope: But et cible sexuels brouillés dans Another Country de James Baldwin

    Directory of Open Access Journals (Sweden)

    Ben Kiely

    2005-01-01

    Full Text Available En grande partie fondé sur les théories « gender » et « queer », cet article aborde Another Country de Baldwin en tant que lieu signifiant d’une réimagination du but et de la cible sexuels. En effet, Baldwin libère ses personnages d’une sexualité unidimensionnelle, statique et concrète. En évitant de « fixer » les désirs de ses personnages, Baldwin met au jour le potentiel kaléidoscopique de l’identité et du désir sexuels. Cet article explore en sus les problèmes de la race et de l’angoisse liée à cette dernière. Quoique Another Country ait fait l’objet d’attaques pour son absence de contenu racial, le traitement par Baldwin de l’identité masculine blanche et du discours identitaire révèle par la même occasion l’incapacité de la société américaine à valider l’expérience du Noir.

  12. [Results of PROMESA I study; efficacy and safety of a very low calorie diet application and following alimentary reeducation with the PronoKal® method in the treatment of excess of weight].

    Science.gov (United States)

    Martínez-Riquelme, Amparo; Sajoux, Ignacio; Fondevila, Joan

    2014-02-01

    Introducción y Objetivos: El objetivo de este estudio fue evaluar la eficacia en la reducción de peso con la utilización de dieta de muy bajo aporte calórico cetogénica y posterior reeducación alimentaria según el método PronoKal ® en pacientes con sobrepeso y obesidad, y la seguridad durante su aplicación. Métodos: Estudio multicéntrico observacional, retrospectivo en que se analizaron estadísticamente variables descriptivas de los pacientes, variables relacionadas con el cambio ponderal, circunferencia de cintura abdominal, y bioquímica general al final de cada una de las etapas de tratamiento, y los acontecimientos adversos referidos en cada visita a lo largo del tratamiento. Resultados: De los 426 casos evaluables, el 62,3% de los pacientes eran obesos. El 16,7% presentaba hiperlipemia, el 2,3% diabetes mellitus tipo 2, y el 4,8% hipertensión arterial. Al final del tratamiento la media de peso perdido fue de 17,1 ± 8,0 kg (p < 0,001), con una reducción del IMC de 6,2 ± 3,0 kg/m2. El 54,2% de pacientes alcanzó la situación de normopeso (35,9% de los obesos), siendo mayor en mujeres que en hombres (62,5% vs 28,2%, respectivamente; p < 0,001). El perímetro de la cintura se redujo en 17,3 ± 9,5 cm. Hubo mejora de todos los parámetros analíticos en los pacientes diabéticos, hipertensos y dislipémicos, alcanzándose la significación estadística (p < 0,05) en la disminución de glucosa (28,8%) en diabéticos, en la disminución de glucosa (12,7%) y colesterol (14,5%) en hipertensos, y en la disminución de glucosa (11,7%), colesterol total (11,9%), colesterol LDL (11,3%) y triglicéridos (37,9%) en dislipémicos. La aparición de acontecimientos adversos se refirió en el 23,7% de los pacientes, principalmente estreñimiento (23,9%). Conclusiones: El método PronoKal® es un método eficaz y seguro de abordaje del exceso de peso, cuando se realiza de forma completa y bajo estricto control clínico multidisciplinar, mejorando diferentes par

  13. Gender stereotypes in primary school Turkish textbooksİlkokul Türkçe ders kitaplarında toplumsal cinsiyet kalıp yargıları

    Directory of Open Access Journals (Sweden)

    Başak Kasa

    2016-10-01

    örünen bazı metinler ve resimler, bireyler arasında cinsiyet farklılığı gözetebilmektedir. Bu sunulan farklılıklar birey tarafından benimsenerek bireyin kendine ilişkin anlamlar çıkarmasına, değerler yüklemesine ve edindiği bu bilgileri yaşama aktarmasına neden olmaktadır. Bu çalışmada Milli Eğitim Bakanlığı (MEB Devlet Kitapları yayınlarının İlkokul 1-4. sınıf Türkçe ders kitaplarında yer alan metinler ve resimler toplumsal cinsiyet kalıp yargıları açısından incelenmiştir. Nitel araştırma yaklaşımın benimsendiği araştırmada veriler doküman incelemesi yoluyla toplanmıştır. İlkokul Türkçe ders kitaplarında yer alan metinlerdeki ve resimlerdeki karakterler toplumsal cinsiyet kalıp yargıları açısından incelenmiş ve toplanan veriler içerik analizi ile çözümlenmiştir. Elde edilen bulgular sonucunda ilkokul Türkçe ders kitaplarında yer alan metinlerde ve görsellerde toplumsal cinsiyet kalıp yargılarının yer aldığı görülmüştür.

  14. Resultados del estudio PROMESA I: eficacia y seguridad de la aplicación de una dieta de muy bajo aporte calórico y reeducación alimentaria posterior mediante el método PronoKal® en el tratamiento del exceso de peso

    OpenAIRE

    Amparo Martínez-Riquelme; Ignacio Sajoux; Joan Fondevila

    2014-01-01

    Introducción y Objetivos: El objetivo de este estudio fue evaluar la eficacia en la reducción de peso con la utilización de dieta de muy bajo aporte calórico cetogénica y posterior reeducación alimentaria según el método PronoKal® en pacientes con sobrepeso y obesidad, y la seguridad durante su aplicación. Métodos: Estudio multicéntrico observacional, retrospectivo en que se analizaron estadísticamente variables descriptivas de los pacientes, variables relacionadas con el cambio ponderal, cir...

  15. Karabük İçin Dış Duvar Optimum Yalıtım Kalınlığının Enerji Tasarrufu Ve Hava Kirliliğine Etkileri / The Effect Of External Wall Optimum Insulation Thickness On Energy Saving And Air Pollution For Karabük

    Directory of Open Access Journals (Sweden)

    Ali Etem Gürel

    2012-12-01

    Full Text Available Bina dış duvarlarında yapılacak ısı yalıtım uygulamaları, yakıt tüketimini düşürerek ekonomik kazanç sağlamanın yanında, fosil kaynaklı yakıt kullanımından kaynaklanan ve hava kirliliğine neden olan emisyonların düşürülmesinde de son derece etkilidir. Bu çalışmada Karabük’te kömür ve doğalgaz kullanımında dış duvar optimum yalıtım kalınlığı tespitinin ekonomik ve çevresel analizi yapılmıştır. Çalışmanın ekonomik boyutu, yaşam döngüsü maliyet analizine (LCCA dayanan P1-P2 yöntemi ile gerçekleştirilmiştir. Çalışmanın sonuçları, yakıt olarak kömür kullanıldığında optimum yalıtım kalınlığı ve enerji tasarrufunun sırasıyla 0.135 m ve 129.42 TL/m² olduğunu göstermiştir. Yakıt olarak doğalgaz kullanımında ise bu değerler sırasıyla 0.118 m ve 98.01 TL/m² olarak bulunmuştur. Optimum yalıtım kalınlığının hava kirliliğine olan etkileri incelendiğinde, yalıtımsız bina dış duvarında hesaplanan yıllık yakıt tüketimi, CO2 ve SO2 emisyonlarının yakıt tipine bağlı olarak optimum yalıtım kalınlığı noktasında %86’ya kadar azaldığı hesaplanmıştır. The Effect Of External Wall Optimum Insulation Thickness On Energy Saving And Air Pollution For Karabük Heat insulation applications carried out on external walls of building provides energy saving by decreasing fuel consumption and also quite important in decreasing emission which results from fossil-based fuel usage and causes air pollution. In this study, economic and environmental analyses were done for determination of external wall optimum thickness in using coal and natural gas usage in Karabük. Economic extent of the study was done with P1-P2 method which is based on life cycle cost analysis (LCCA. The results show that optimum insulation thickness and energy saving are 0.134 m and 117.14 TL/m² respectively when coal is used as a fuel. These values are 0.116 m and 88.39 TL

  16. Yeni Tanılı Diyabetes Mellitus Hastalarında Peripapiller Retina Sinir Lifi Tabakası Ve Subfoveal Koroid Kalınlığının Spektralis OCT İle Değerlendirilmesi

    Directory of Open Access Journals (Sweden)

    Muhammed Şahin

    2016-09-01

    Full Text Available Amaç: Bu çalışmada amacımız, yeni tanı alan ve her­hangi bir diyabetik retinopati (DR bulgusu olmayan tip 2 diyabetes mellituslu (DM olgularla sağlıklı bireylerin peri­papiller retina sinir lifi tabakası (pRSLT ve koroid tabaka­sı kalınlıklarını karşılaştırmaktır. Yöntemler: Çalışmaya Endokrin polikliniğinden yeni tanı almış ve DR’si olmayan DM’li hastalar ile sağlıklı kontrol grubu dahil edildi. Olguların Spectral-Domain optik kohe­rens tomografi (spektralis OKT cihazı ile EDI modunda (enhanced depth imaging- artırılmış derinlik görüntüleme­si horizontal düzlemde taraması yapıldı. Alınan görün­tülerden fovea merkezinden, fovea merkezine 1000 μm temporal ve nazalden koroid kalınlıkları ölçümü yapıldı. Ayrıca aynı cihazla pRSLT kalınlık ölçümü yapıldı. Bulgular: Çalışmaya DR’si olmayan 28 yeni tanılı DM hastasının 28 gözü ile 28 kontrol grubunun 28 gözü da­hil edildi. Yaş, cinsiyet, sferik ekivalan, düzeltilmiş en iyi görme keskinliği, göz içi basıncı ve aksiyel uzunluk de­ğerlerinde gruplar arasında anlamlı farklılık saptanmadı. Subfoveal ve temporal alanda koroid kalınlığının yeni ta­nılı DM grubunda kontrol grubuna göre daha ince olduğu saptandı (sırasıyla p=0,04, p=0,006. pRNFL analizinde ise averaj, nazal ve temporal süperior kadranlar yeni tanılı DM grubunda kontrol grubuna göre anlamlı olarak daha ince bulundu. Diğer pRNFL kadranlarında anlamlı bir fark saptanmadı. Sonuç: Çalışmamızın verileri değerlendirildiğinde yeni tanılı DM’li hastalarda DR bulguları olmaksızın koroid ta­bakasında incelmenin yanında pRSLT’de bazı incelmele­rin (özellikle averaj, nazal ve temporal süperior kadranlar­da olabileceğini söylemek mümkün görünmektedir.

  17. Yaşam Temelli Öğretim ve Öğrenme İstasyonları Yönteminin 9. Sınıf Fizik Ders Başarısı ve Kalıcılığa Etkileri

    Directory of Open Access Journals (Sweden)

    Serim KORSACILAR

    2015-08-01

    Full Text Available Bu araştırmada, öğrenme istasyonları yöntemi ile Türkiye’de lise düzeyi fizik öğretim programının temel yapısında yer verilen yaşam temelli öğretim yönteminin, öğrencilerin fiziğin doğası ile ilgili temel bilgilere yönelik ders başarıları ve kalıcılık üzerindeki etkilerini incelemek amaçlanmıştır. Araştırmanın çalışma grubu, bir devlet lisesinde 9. Sınıf düzeyinde üç ayrı sınıfta öğrenim gören 84 öğrenciden oluşmuştur. Araştırmada ön test-son test kontrol gruplu yarı deneysel araştırma modeli kullanılmış; araştırma, Öğrenme İstasyonları Grubu (n=28 ve Yaşam Temelli Öğretim Grubu (n=28 olarak iki deney, Geleneksel Öğretim Grubu olarak bir kontrol grubu (n=28 üzerinde yürütülmüştür. Bu araştırmada veri toplama aracı olarak “Fiziğin Doğası” ünitesindeki temel bilgilere yönelik ders başarılarını ölçmek amacıyla “Fiziğin Doğası Ünitesi Klasik Sınavı” kullanılmıştır. Araştırmanın sonucunda, öğrenme istasyonları grubundaki öğrencilerin başarı puanlarının diğer iki gruba göre anlamlı düzeyde daha yüksek olduğu; her üç grupta da öğrencilerin kalıcı öğrenmeler gerçekleştirdikleri ve gruplar arasında öğrenmelerin kalıcılıkları bakımından anlamlı bir farklılık göstermediği sonucuna ulaşılmıştır. 

  18. Sanal Gerçeklik Programlarının Astronomi Konularının Öğretiminde Kullanılmasının Akademik Başarı ve Kalıcılığa Etkisi

    Directory of Open Access Journals (Sweden)

    Hilal Aktamış

    2012-11-01

    Full Text Available Bu araştırmada üç boyutlu görsel tasarımları içeren sanal gerçeklik programlarının, ilköğretim 7. sınıf öğrencilerinin fen ve teknoloji dersi astronomi konusundaki başarılarına ve kalıcılıklarına etkisini araştırmak amaçlanmıştır. Bu kapsamda ilköğretim 7. sınıf öğrencilerinin zihinlerinde astronomi konularını daha iyi yapılandırabilmesi için sanal gerçeklik programlarına uygun etkinlik yaprakları geliştirilmiş ve Aydın ilinde sosyoekonomik bakımdan alt düzeydeki bir İlköğretim okulunda yer alan yedinci sınıf öğrencilerine uygulanmıştır. Araştırmanın çalışma grubunu deney grubunda 30, kontrol grubunda 30 öğrenci olmak üzere toplam 60 öğrenci oluşturmaktadır. Araştırmada kullanılan 20 maddelik Astronomi Başarı Testi'nin cronbach alfa güvenirlik katsayısı .76 olarak hesaplanmış ve çalışma grubundaki öğrencilere uygulama öncesi ön test, uygulama sonrası son test ve uygulamadan üç ay sonra kalıcılık testi olarak uygulanmıştır. Uygulama sonucuna göre sanal gerçeklik programları kullanılarak yapılan öğretim sonucunda deney grubunun akademik başarısının kontrol grubuna göre daha fazla arttığı görülmüştür. Sanal gerçeklik programları kullanılarak yapılan öğretimin öğrencilerin akademik başarılarını arttırmada daha etkili olduğu ortaya çıkmıştır.

  19. Resultados del estudio PROMESA I: eficacia y seguridad de la aplicación de una dieta de muy bajo aporte calórico y reeducación alimentaria posterior mediante el método PronoKal® en el tratamiento del exceso de peso

    Directory of Open Access Journals (Sweden)

    Amparo Martínez-Riquelme

    2014-02-01

    Full Text Available Introducción y Objetivos: El objetivo de este estudio fue evaluar la eficacia en la reducción de peso con la utilización de dieta de muy bajo aporte calórico cetogénica y posterior reeducación alimentaria según el método PronoKal® en pacientes con sobrepeso y obesidad, y la seguridad durante su aplicación. Métodos: Estudio multicéntrico observacional, retrospectivo en que se analizaron estadísticamente variables descriptivas de los pacientes, variables relacionadas con el cambio ponderal, circunferencia de cintura abdominal, y bioquímica general al final de cada una de las etapas de tratamiento, y los acontecimientos adversos referidos en cada visita a lo largo del tratamiento. Resultados: De los 426 casos evaluables, el 62,3% de los pacientes eran obesos. El 16,7% presentaba hiperlipemia, el 2,3% diabetes mellitus tipo 2, y el 4,8% hipertensión arterial. Al final del tratamiento la media de peso perdido fue de 17,1 ± 8,0 kg (p < 0,001, con una reducción del IMC de 6,2 ± 3,0 kg/m². El 54,2% de pacientes alcanzó la situación de normopeso (35,9% de los obesos, siendo mayor en mujeres que en hombres (62,5% vs 28,2%, respectivamente; p < 0,001. El perímetro de la cintura se redujo en 17,3 ± 9,5 cm. Hubo mejora de todos los parámetros analíticos en los pacientes diabéticos, hipertensos y dislipémicos, alcanzándose la significación estadística (p < 0,05 en la disminución de glucosa (28,8% en diabéticos, en la disminución de glucosa (12,7% y colesterol (14,5% en hipertensos, y en la disminución de glucosa (11,7%, colesterol total (11,9%, colesterol LDL (11,3% y triglicéridos (37,9% en dislipémicos. La aparición de acontecimientos adversos se refirió en el 23,7% de los pacientes, principalmente estreñimiento (23,9%. Conclusiones: El método PronoKal® es un método eficaz y seguro de abordaje del exceso de peso, cuando se realiza de forma completa y bajo estricto control clínico multidisciplinar, mejorando

  20. Sanal Gerçeklik Programlarının Astronomi Konularının Öğretiminde Kullanılmasının Akademik Başarı ve Kalıcılığa Etkisi

    Directory of Open Access Journals (Sweden)

    Hilal Aktamış

    2013-08-01

    Full Text Available Bu araştırmada üç boyutlu görsel tasarımları içeren sanal gerçeklik programlarının, ilköğretim 7. sınıf öğrencilerinin fen ve teknoloji dersi astronomi konusundaki başarılarına ve kalıcılıklarına etkisini araştırmak amaçlanmıştır. Bu kapsamda ilköğretim 7. sınıf öğrencilerinin zihinlerinde astronomi konularını daha iyi yapılandırabilmesi için sanal gerçeklik programlarına uygun etkinlik yaprakları geliştirilmiş ve Aydın ilinde sosyoekonomik bakımdan alt düzeydeki bir İlköğretim okulunda yer alan yedinci sınıf öğrencilerine uygulanmıştır. Araştırmanın çalışma grubunu deney grubunda 30, kontrol grubunda 30 öğrenci olmak üzere toplam 60 öğrenci oluşturmaktadır. Araştırmada kullanılan 20 maddelik Astronomi Başarı Testi'nin cronbach alfa güvenirlik katsayısı .76 olarak hesaplanmış ve çalışma grubundaki öğrencilere uygulama öncesi ön test, uygulama sonrası son test ve uygulamadan üç ay sonra kalıcılık testi olarak uygulanmıştır. Uygulama sonucuna göre sanal gerçeklik programları kullanılarak yapılan öğretim sonucunda deney grubunun akademik başarısının kontrol grubuna göre daha fazla arttığı görülmüştür. Sanal gerçeklik programları kullanılarak yapılan öğretimin öğrencilerin akademik başarılarını arttırmada daha etkili olduğu ortaya çıkmıştır. Normal 0 21 false false false TR X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Normal Tablo"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin-top:0cm; mso-para-margin-right:0cm; mso-para-margin-bottom:10.0pt; mso-para-margin-left:0cm; line-height:115%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso

  1. Sharma's Python Sign: A New Tubal Sign in Female Genital Tuberculosis.

    Science.gov (United States)

    Sharma, Jai Bhagwan

    2016-01-01

    Female genital tuberculosis (FGTB) is an important cause of infertility in developing countries. Various type of TB salpingitis can be endosalpingitis, exosalpingitis, interstitial TB salpingitis, and salpingitis isthmica nodosa. The fallopian tubes are thickened enlarged and tortuous. Unilateral or bilateral hydrosalpinx or pyosalpinx may be formed. A new sign python sign is presented in which fallopian tube looks like a blue python on dye testing in FGTB.

  2. Kalós Dionisos [Theoc.] 20.33

    OpenAIRE

    Montes Cala, José Guillermo

    1999-01-01

    Las presentes páginas tienen por objeto clarificar la mención de Dioniso como pastor en el verso 33 del Idilio 20, la cual ha causado a los críticos problemas textuales e interpretativos. el texto ransmitido en este verso es correcto y no es necesario alterarlo. kaloV DionusoV sugiere la imagen efébica del dios en relación estrecha con el innominado boyerito y portin elaunei, aquí con el sentido metafórico de «hacer el amor», es una expresión no obstante ambigua que el poeta inteligentemente ...

  3. Laparoskopiassisteret ileocøkal resektion ved Crohns sygdom

    DEFF Research Database (Denmark)

    Laursen, Stig Borbjerg; Knudsen, Torben; Poornoroozy, Peiman

    2010-01-01

    Laparoscopic surgery has become more widely used in the treatment of patients with inflammatory bowel disease. The aim of this study is retrospectively to describe the results of laparoscopy-assisted ileocolic resection of nineteen patients with Crohn's disease....

  4. SERVİKAL ARTROZ ENSİDANSI VE SERVİKAL KOLON BİOMEKANİĞİ

    OpenAIRE

    Goksoy, Turgut; Kokino, Siranus; Cevher, Gulriz

    2004-01-01

    The data obtained from our outpatient clinic of Physical Theraphy and Rehabilitation at the Medical Faculty of Cerrahpaşa from May 1977 to May 1978 have been carefully worked out. The insidance of cervical arthrosis in respect to the total arthrosis has been presented. The variations in he course of the disease according to age, sex, vocational problems and months have been showed and the results have been statiscatiy evaluated.

  5. Broadening of a spectrum line by finite spectrometer resolution. [FORTRAN IV; SAL, KAL

    Energy Technology Data Exchange (ETDEWEB)

    Engleman, R. Jr.

    1978-12-01

    The distortion of a spectrum line by the finite resolving power of a spectrometer is discussed in terms of a mathematical model. Particular attention is given to the case where either a Gaussian or Cauchy slit function broadens an isolated Doppler, Lorentz, or Voigt absorption line. Corrections to the peak absorption, the line width, and the integrated absorption coefficient are calculated and discussed for different combinations of slit functions and line shapes. Several new series expansions for the corrections are derived. Two general FORTRAN IV programs that calculate these corrections are described and some sample correction curves are given. 27 references.

  6. Recidiverende Clostridium Difficile infektion behandlet med fækal transplantation

    DEFF Research Database (Denmark)

    Fløe, Andreas; Leutscher, Peter

    2014-01-01

    Treatment of severe Clostridium difficile infection (CDI) poses a clinical challenge. Emerging evidence supports the use of faecal microbiota transplantation (FMT). An 81-year-old man was admitted with a third recurrent episode of CDI within two months. Because of clinical deterioration with deve......Treatment of severe Clostridium difficile infection (CDI) poses a clinical challenge. Emerging evidence supports the use of faecal microbiota transplantation (FMT). An 81-year-old man was admitted with a third recurrent episode of CDI within two months. Because of clinical deterioration...

  7. kal calprotectin er en klinisk anvendelig markør for intestinal inflammation

    DEFF Research Database (Denmark)

    Theede, Klaus; Kiszka-Kanowitz, Marianne; Nordgaard-Lassen, Inge

    2014-01-01

    Faecal calprotectin is a biomarker for inflammation in the intestinal mucosa. Faecal calprotectin has the ability to detect inflammatory causes of gastrointestinal symptoms and to distinguish these from irritable bowel syndrome. The test is very sensitive but not specific to any particular...

  8. [Spatial distribution and species composition of prosthecate bacteria in Lake Baĭkal].

    Science.gov (United States)

    Lapteva, N A; Bel'kova, N L; Parfenova, V V

    2007-01-01

    From the water column of Lake Baikal, several strains of prosthecate bacteria belonging to the genera Caulobacter and Brevundimonas were isolated. In this article, the methods applied for their isolation and cell number determination are described; the occurrence frequency and spatial distribution of these microorganisms in the lake are demonstrated. Characterization of the species composition of cultivable and uncultivable prosthecate bacteria was carried out using the methods of traditional and molecular microbiology, respectively. A comparative phylogenetic analysis of the DNA sequences of uncultivable bacteria, which showed homology to the members of the alpha subclass of proteobacteria, was carried out. It was demonstrated that the lake water column is inhabited by uncultivable alpha-proteobacteria of uncertain phylogenetic affinity, in addition to representatives of the species Caulobacter vibrioides and C. leidyi, which were detected by traditional microbiological methods.

  9. PARAPSORİASİS PLAĞINDA TOPİKAL FOTODİNAMİK TEDAVİ

    OpenAIRE

    Can CEYLAN; ÖZDEMİR, Fezal; KAZANDI, Alican

    2001-01-01

    Photodynamic therapy is a treatment modality mainly effective in epithelial precancerous and cancerous lesions like actinic keratoses, Bovven's disease and nonmelanoma skin cancer. The method is based on the destruction of diseased îissue by reactive oxygen intermediates generated though the interaction of light with a photosensitizer agent. The iarge plaque parapsoriasis is a lesion that may progress to mycosis fungoides. The goa! of îhis study was to determine the effectiveness of photo...

  10. The Shootdown of KAL (Korean Air Lines) 007: Accident or Conspiracy?

    Science.gov (United States)

    1988-04-01

    theory were true; "...most readers will likely agree that it is the only one that makes sense." (10:67) The book review section of the Library Journal finds...ILt, USAP. "Book Reviews." _ Institute Procedings, June 1987, pp. 110-111. 8. Kuhulman, James R. "Book Reviews." Library Journal ., 15 June 1986, p. 60

  11. Suvemõisad keisrinna soolatüükal / Meeli Müüripeal

    Index Scriptorium Estoniae

    Müüripeal, Meeli, 1963-

    2007-01-01

    Romanovitele kuulunud suvemõisatest (Livadija, Massandra - arhitektid M. E. Bouchard ja Maksimilian Messmacher (1842-1906), Oreanda - arhitekt Hans (Andrei) Stackenschneider, 1852 ning Nikolai Krasnovi (1864-1939) projekteeritud Djulber,1897, Livadija, 1911, Haraks ja Tshaiir) Krimmis. Lk. 28: Aaspõllu, Aino. Sära kaotanud kuulsad pargid (Livadija, Oreanda, Massandra)

  12. Plastik Enjeksiyon Kalıplarında PVC (Polivinil Klorür ve PC (Polikarbonat İçin En Uygun Kalıp Çeliği Seçimi

    Directory of Open Access Journals (Sweden)

    Hüseyin Veli DÖNDÜREN

    2015-09-01

    Full Text Available With each passing day, the use of plastics in the life of human beings with a further increase of the field, the plastics gligibly small. In this study, PVC (Polyvinyl Chloride and PC (Poindustry has evolved to the present day. Because of increased demand and competition, plastics technology continues to evolve rapidly. Work on the plastic technology to further grow while maintaining its position in the industry in our country are continuing. In these studies reinforced plastics, heat, temperature, pressure such variables has been working on. But

  13. Variable penetrance of hypogonadism in a sibship with Kallmann syndrome due to a deletion of the KAL gene

    Energy Technology Data Exchange (ETDEWEB)

    Parenti, G.; Rizzolo, M.G.; Ghezzi, M. [Federico II University, Naples (Italy)] [and others

    1995-07-03

    We report on the clinical and molecular characterization of 3 sibs with X-linked ichthyosis and variable expression of Kallmann syndrome. One of the affected brothers had mild hyposmia and showed normal pubertal progression. However, we demonstrated the same partial deletion of the X-linked Kallmann gene, sparing the first exon in the mildly affected patient as well as in one of his severely affected brothers. 13 refs., 1 fig., 1 tab.

  14. Potash alum [KAl(SO4)2.12H2O] catalysed esterification of formylphenoxyaliphatic acids

    Indian Academy of Sciences (India)

    Ganesan Shunmugadhas Suresh Kumar; Sudalaiandi Kumaresan

    2012-07-01

    A convenient and clean procedure for esterification is reported. Direct condensation of formylphenoxyaliphatic acids with low to high boiling alcohols catalysed by potash alum gave moderate to good yields. This catalyst could be recovered and reused without substantial loss in its catalytic activity and the methodology could be used for a range of closely related substrates.

  15. Comment to: Haque S, Khan A, Sharma A, Sundararajan S: Technical tip: tightrope fixation of neer type II distal clavicle fracture supported by a case series. Pol Orthop Traumatol, 2014; 79: 19-22.

    Science.gov (United States)

    Gökkuş, Kemal; Saylik, Murat; Aydin, Ahmet Turan

    2014-04-15

    Additional suture anchor fixation to coracoclaviculer area with precountered distal clavicle locking plate allows an anatomic reduction with bone-bone contact and gives additional neutralisation effect with coracoclavicular suture anchor fixation against the trapezius muscle pulling effect .Event though the effeciency of this technique reported by other authors,still there is a few articles and cases reported.In the terms of proving the efficiency of the combination technique we would like to stress to contribute the published article by Haque et al.

  16. YAYLI ÇALGI EĞİTİMİNDE MÜZİKAL İFADENİN GELİŞTİRİLMESİ

    Directory of Open Access Journals (Sweden)

    Hasan Hakan Okay

    2013-04-01

    Full Text Available In the instrument training process, the development of musical expression is an important requirement. This research aims to determine the effect of the method that is easy to understand that will allow students to create their own strategies for the development of musical expression and which takes its source from the relationship between music and language also the relationship between the instrumental music and song. Studies have indicated with neurophysiological evidence that the language and the music carries a very important partnerships. Instrumental music, stands out as a case that takes its source from song when assessed with the understanding of instruments oppointed as a soloist. Therefore, the method is designed based on this understanding to recognize music and instrumental music. Theoretical aspect of the method used is given in the research report in detail due to its original structure.Pretest - posttest experimental and control group experimental research design was used. The research were applied in Balıkesir University Necatibey Education Faculty Education Department of Fine Arts Music Education Branch on Fall Semester of the 2009-2010 Academic Year in 10-week training period with participation of 20 students. Datas were gathered by “Musical Expression Performance Scale”. In the end of experimental study has resulted in favor of the experimental group.

  17. Optical excitation processes in the near band-edge region of KAlSi3O8 and NaAlSi3O8 feldspar

    DEFF Research Database (Denmark)

    Poolton, N.R.J.; Mauz, B.; Lang, A.;

    2006-01-01

    A complex variety of excitation and relaxation pathways are available for charge in naturally occurring NaAlSi3O8 and KAlpSi(3)O(8) feldspar crystals, when excited with photons in the trans-band-edge energy range 4-12 eV These can involve a mixture of electronic transitions associated with defect...... states, the conduction and valence bands and their associated band-tails. In order to demonstrate that a relationship exists between these processes, combinations of three spectroscopic techniques are deployed in this work: luminescence excitation/emission mapping, energy-resolved photo...... emission in the materials. Luminescence and phosphorescence excitation spectra provide additional, complementary, information regarding the excited states of the blue-emitting defects, including their transition lifetimes and decay paths. Red emission associated with Fe3+ luminescence is mostly isolated...

  18. Tünel Kalıp Teknolojisinin Tasarıma Getirdiği Olanak ve Kısıtlamalar

    OpenAIRE

    Şahin, Berrin

    2016-01-01

    The possibilities and restrictions of the tunnel formwork technology which has been often used in the last two decades in Türkiye, has to be known thoroughly in order to design and produce better projects. This is the reason why, firstly the tunnel formworks are described. The elements constituting the tunnel formworks, the dimensions and the way they get together to form spaces are explained in this paper Later the possibilities and restrictions of the tunnel formworks bring w the design are...

  19. Elektron-Alüminyum Etkileşiminde Depolanan Enerjinin Hedef Kalınlığı ile Değişimi

    Directory of Open Access Journals (Sweden)

    Zehra Nur DEMİRCİ

    2014-07-01

    Full Text Available Accelerators, which are high technology, has been setup in a large number of facility in the world. The accelerated beams can be used in particle or nuclear physics experiment. Thickness of target, which used in production bremsstrahlung photon by accelerated electrons, is important. In this study, the variation of energy deposition with target thickness has been investigated due to interaction of 8 MeV energy accelerated electron beam with aluminum target at different thicknesses. Depending the target thickness of energy deposition on Al target has been simulated using FLUKA code. The energy deposition on the target has increased with increasing thickness of target material

  20. [The new eubacterium Roseomonas baikalica sp. nov. isolated from core samples collected by deep-hole drilling of the bottom of Lake Baĭkal].

    Science.gov (United States)

    Andreeva, I S; Pechurkina, N I; Morozova, O V; Riabchikova, E I; Belikov, S I; Puchkova, L I; Emel'ianova, E K; Torok, T; Repin, V E

    2007-01-01

    Microbiological analysis of samples of sedimentary rocks from various eras of the geological history of the Baikal rift has enabled us to isolate a large number of microorganisms that can be classified into new, previously undescribed species. The present work deals with the identification and study of the morphological, biochemical, and physiological properties of one such strain, Che 82, isolated from sample C-29 of 3.4-3.5 Ma-old sedimentary rocks taken at a drilling depth of 146.74 m. As a result of our investigations, strain Che 82 is described as a new bacterial species, Roseomonas baikalica sp. nov., belonging to the genus Roseomonas within the family Methylobacteriaceae, class Alphaproteobacteria.

  1. Translational implication of Kallmann syndrome-1 gene expression in hepatocellular carcinoma.

    Science.gov (United States)

    Tanaka, Yuri; Kanda, Mitsuro; Sugimoto, Hiroyuki; Shimizu, Dai; Sueoka, Satoshi; Takami, Hideki; Ezaka, Kazuhiro; Hashimoto, Ryoji; Okamura, Yukiyasu; Iwata, Naoki; Tanaka, Chie; Yamada, Suguru; Fujii, Tsutomu; Nakayama, Goro; Koike, Masahiko; Nomoto, Shuji; Fujiwara, Michitaka; Kodera, Yasuhiro

    2015-01-01

    Accumulation of epigenetic alterations causes inactivation of tumor suppressors and contributes to the initiation and progression of hepatocellular carcinoma (HCC). Identification of methylated genes is necessary to improve our understanding of the pathogenesis of HCC and develop novel biomarkers and therapeutic targets. The Kallmann syndrome-1 (KAL1) gene encodes an extracellular matrix-related protein with diverse oncological functions. However, the function of KAL1 in HCC has not been examined. We investigated the methylation status of the KAL1 promoter region in HCC cell lines, and evaluated KAL1 mRNA levels and those of genes encoding potential interacting cell adhesion factors. KAL1 mRNA expression level was heterogeneous in nine HCC cell lines, and reactivation of KAL1 mRNA expression was observed in cells with promoter hypermethylation of KAL1 gene after demethylation. In addition, KAL1 mRNA levels inversely correlated with those of ezrin in all nine HCC cell lines. KAL1 expression levels in 144 pairs of surgically-resected tissues were determined and correlated to clinicopathological parameters. KAL1 mRNA level was independent of the background liver status, whereas HCC tissues showed significantly lower KAL1 mRNA levels than corresponding noncancerous liver tissues. Downregulation of KAL1 mRNA in HCC was significantly associated with malignant phenotype characteristics, including elevated tumor markers, larger tumor size, vascular invasion, and hypermethylation of KAL1. Patients with downregulation of KAL1 were more likely to have a shorter overall survival than other patients, and multivariate analysis identified downregulation of KAL1 as an independent prognostic factor (hazard ratio 2.04, 95% confidence interval 1.11-3.90, P=0.022). Our results indicated that KAL1 may act as a putative tumor suppressor in HCC and is inactivated by promoter hypermethylation. KAL1 may serve as a biomarker of malignant phenotype of HCC.

  2. LEXICAL DETERMINATIONS ON SOME DRINK NAMES IN HISTORICAL TURKIC DIALECTS TARİHÎ TÜRK LEHÇELERİNDE GEÇEN BAZI İÇECEK ADLARI HAKKINDA LEKSİKAL TESPİTLER

    Directory of Open Access Journals (Sweden)

    Mehmet Turgut BERBERCAN

    2010-10-01

    Full Text Available In this article, with a thematic review, in the concept of Turkish language and culture history, as cultural elements of old Turkish culture, ten drink names (baxsum, bāziq, begni, bor, boza, çaqır, seker, suwsuş, sorma, süçig used in texts of historical Turkish dialects (Old and Middle Turkic from 10th century to 16th century are expounded in terms of lexicology by indicating the passages where the names occur. As a result, in the light of all the information accumulated, the names are analysed from the point of morphology, semantics and etymology and the area of their linguistic notions comprised are given in detail. Bu makalede, tematik bir örgü dahilinde, Türk dili ve kültürü tarihi kapsamında, tarihi Türk lehçelerinde geçen (Eski ve Orta Türkçe, yaklaşık olarak 10. yüzyıldan 16. yüzyıla kadar eski Türk kültürünün bir parçası olmak suretiyle Türk dili ve edebiyatında yer bulmuş olan on içecek adı (baxsum, bāziq, begni, bor, boza, çaqır, seker, suwsuş, sorma, süçig, içinde geçtikleri metin parçalarıyla beraber, leksikolojik (kelimebilimsel açıdan incelenmiş, eldeki verilerin ışığında; yapı, anlam ve köken bilgisi açısından analiz edilerek dilbilimsel kavram alanları ortaya konmaya çalışılmıştır.

  3. Kvantifikace produkce výkalů - trusu vybraných jelenovitých v chovech podle zvláštních předpisů.

    OpenAIRE

    2013-01-01

    The work is focused on the production of deer droppings, black, fallow deer and mouflon. For this reason, the aim of this work is to determine the content of selected elements and findings of spring tribal condition of the game in the Highlands and the total amount of excreted droppings. According to collected information it can be concluded that a standard condition of deer causes no environmental pollution. In contrast, when there is an overpopulation of deer it can cause a negative impact ...

  4. Santral Kornea Kalınlığının Ultrasonik Pakimetre, Optik Kohorens Tomografi ve Placido-Disk Korneal Topografi ile Kombine Scheimpflug Kamera ile Karşılaştırılması

    OpenAIRE

    KALAYCI, Mustafa; Güneş, Alime; Özertürk, Yusuf

    2014-01-01

    Background: To compare the results of ultrasonic pachymetry, optical cohorence tomography and Scheimpflug camera combined with Placido-disk corneal topography in central corneal thickness measurement. Material and Methods: Central corneal thickness was measured with ultrasonic pachymetry, optical cohorence tomography and Scheimpflug camera combined with Placido-disk corneal topography in 112 eyes of 112 healthy volunteers between the ages of 15 and 65 years. The measurements of each instrumen...

  5. Koroner Arter Kalsiyum Skor İndeksi ile Karotis ve Yüzeyel Femoral Arterlerin İntima Media Kalınlıkları Arasındaki İlişkinin Değerlendirilmesi

    OpenAIRE

    VARDI, Eşref Cem; BOZGEYİK, Zülkif; POYRAZ, Ahmed Kürşad; Onur, Mehmet Ruhi

    2012-01-01

    Objective: To investigate the relationship between intima-media thicknesses (IMT) of carotid and superficial femoral arteries and coronary artery calcium index quantified using Agatston score. Materials and Methods: Cardiac multidetector computed tomography (MDCT) angiography of 75 patients were included in the study. Coronary artery calcium scores were measured using a workstation. Calcium scores were calculated according to the Agatston method. Bilateral carotid artery and superficial f...

  6. 基于 Kal man 滤波的人体心电跟踪监测系统设计%Design of human ECG monitoring system based on Kalman filter

    Institute of Scientific and Technical Information of China (English)

    刘俊杰; 柳桂国; 宋栓军

    2016-01-01

    Aimed at ECG health care for families ,and improving the accuracy of the low power monitoring ECG monitoring system ,an ECG monitoring system using Kalman filter is designed and implemented .The weak ECG signals are extracted by electrodes and ECG collecting line of three lead ,and then filtered and amplified through the analog front using AD8232 , then the STM32 processor is used for Kalman filter processing . At last , the actual ECG characteristics of biological electrical signals and heart rate are got in the LCD .Tested by the experimental prototype , under the condition of the human body being quiet ,the result in the LCD is clear and stable ,and can reflect the actual electrical characteristics of the human body .The results show that the design successfully completed the ECG signal filter processing ,can meet the needs of home ECG monitoring ,which means a certain reference value for family medical equipment .%针对家庭心电健康监护,以及提高低功耗心电监测系统监测的准确性,设计并实现了一种采用卡尔曼滤波的心电监测系统。该系统采用AD8232作为模拟前段对通过电极和三导联心电采集线提取的微弱心电信号进行滤波放大,再经STM32处理器进行卡尔曼滤波处理,最终在LCD得到清晰稳定的生物电信号及心率。经实验样机初步测试,在人体保持安静的情况下,LCD显示的心电信号清晰稳定,能够反映人体实际心电特征。结果表明该设计较好地完成了心电信号的滤波处理,能够满足家庭心电监测的需求,对于家庭医疗设备有一定参考价值。

  7. GRAMMATICAL AFFIX CATEGORY IN JAPANESE LANGUAGE (IN COMPARISON WITH AZERBAIJANIAN LANGUAGE JAPON DİLİNDE GRAMATİKAL KİP KATEGORİSİ (AZERİCEYLE MÜKAYESEDE

    Directory of Open Access Journals (Sweden)

    O. B. CELİLBEYLİ

    2009-12-01

    Full Text Available In the article, the category of affix in japanese language is looked through according to the context of monography “The grammar of contemporary Japanese language ” (1986 by great soviet and russian japanese critic I.V.Golovnin. In japanese language, the grammatical affix category is given in appropriate morphological forms and their meanings are expressed by certain verbs from original japanese texts. The translations of these text into azerbaijanian language, the surroundings of use of these categories, the ways of their expressions and meanings in azerbaijanian language give us certain imagination as well. Makale ünlü Rus Japon dili uzmanı İ. V. Golovnin¢in “Çağdaş Japon Dilinin Grameri” (1986 kitabındaki temel fikirlere dayanılarak Kip konusu incelenmiş bulunmaktadır. Japon Dilinde Kip¢ler gereken morfoloji ekler yardımıyle türetilse de onların belirttiği anlamları söz konusu Eylemlerin (Kiplerin Japon dilindeki metinlerde açığa kavuşturulabiliyor. Japon Dili metinlerinin Azericeye çevirisi zamanı çeşitli kip eki almış eylemlerin Azericeye çevirisinin özelliği, çeviri yolu ve usulleri belli olmuştur.

  8. Functional characterization of the kinase activation loop in nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) using tandem affinity purification and liquid chromatography-mass spectrometry.

    Science.gov (United States)

    Wang, Peng; Wu, Fang; Ma, Yupo; Li, Liang; Lai, Raymond; Young, Leah C

    2010-01-01

    Previous studies have shown that the kinase activation loop (KAL) of the oncogenic fusion protein NPM-ALK regulates its overall tyrosine phosphorylation status and tumorigenicity. Using tandem affinity purification-mass spectrometry, we assessed how the KAL of NPM-ALK regulates the phosphorylation status of its individual tyrosines. Using the lysates of GP293 cells transfected with NPM-ALK, our highly reproducible results showed evidence of phosphorylation in all 3 tyrosines in KAL and 8 tyrosines outside KAL. We created 7 KAL mutants, each of which carried a Tyr-to-Phe mutation of >or=1 of the 3 tyrosines in KAL. A complete loss of the 8 phosphotyrosines outside KAL was found in 3 KAL mutants, and their oncogenicity (assessed by cell viability, colony formation, and the ability to phosphorylate effector proteins) was abrogated. A partial loss of the 8 phosphotyrosines was found in 4 KAL mutants, but their oncogenicity did not show simple correlation with the number of residual phosphotyrosines. Tyr-to-Phe mutations of each of the 8 phosphotyrosines outside KAL did not result in a significant decrease in the oncogenicity. In conclusion, we have provided details of how the KAL in NPM-ALK regulates its tyrosine phosphorylation pattern. Our results challenge some of the current concepts regarding the relationship between the tyrosine phosphorylation and oncogenicity of NPM-ALK.

  9. Genetic analyses of Acanthamoeba isolates from contact lens storage cases of students in Seoul, Korea.

    Science.gov (United States)

    Yu, H S; Choi, K H; Kim, H K; Kong, H H; Chung, D I

    2001-06-01

    We conducted both the small subunit ribosomal DNA (SSU rDNA) polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and mitochondrial (mt) DNA RFLP analyses for a genetic characterization of Acanthamoeba isolates from contact lens storage cases of students in Seoul, Korea. Twenty-three strains of Acanthamoeba from the American Type Culture Collection and twelve clinical isolates from Korean patients were used as reference strains. Thirty-nine isolates from contact lens storage cases were classified into seven types (KA/LS1, KA/LS2, KA/LS4, KA/LS5, KA/LS7, KA/LS18, KA/LS31). Four types (KA/LS1, KA/LS2, KA/LS5, KA/LS18) including 33 isolates were regarded as A. castellanii complex by riboprints. KA/LS1 type was the most predominant (51.3%) in the present survey area, followed by KA/LS2 (20.9%), and KA/LS5 (7.7%) types. Amoebae of KA/LS1 type had the same mtDNA RFLP and riboprint patterns as KA/E2 and KA/E12 strains, clinical isolates from Korean keratitis patients. Amoebae of KA/LS2 type had the identical mtDNA RFLP patterns with A. castellanii Ma strain, a corneal isolate from an American patient as amoebae of KA/LS5 type, with KA/E3 and KA/E8 strains from other Korean keratitis patients. Amoebae of KA/LS18 type had identical patterns with JAC/E1, an ocular isolate from a Japanese patient. Three types, which remain unidentified at species level, were not corresponded with any clinical isolate in their mtDNA RFLP and riboprint patterns. Out of 39 isolates analyzed in this study, mtDNA RFLP and riboprint patterns of 33 isolates (84.6%) were identical to already known clinical isolates, and therefore, they may be regarded as potentially keratopathogenic. These results suggest that contact lens wearers in Seoul should pay more attention to hygienic maintenance of contact lens storage cases for the prevention of Acanthamoeba keratitis.

  10. Long-term survival following kidney transplantation in previous lung transplant recipients-An analysis of the unos registry.

    Science.gov (United States)

    Osho, Asishana A; Hirji, Sameer A; Castleberry, Anthony W; Mulvihill, Michael S; Ganapathi, Asvin M; Speicher, Paul J; Yerokun, Babatunde; Snyder, Laurie D; Davis, Robert D; Hartwig, Mathew G

    2017-05-01

    Kidney transplantation has been advocated as a therapeutic option in lung recipients who develop end-stage renal disease (ESRD). This analysis outlines patterns of allograft survival following kidney transplantation in previous lung recipients (KAL). Data from the UNOS lung and kidney transplantation registries (1987-2013) were cross-linked to identify lung recipients who were subsequently listed for and/or underwent kidney transplantation. Time-dependent Cox models compared the survival rates in KAL patients with those waitlisted for renal transplantation who never received kidneys. Survival analyses compared outcomes between KAL patients and risk-matched recipients of primary, kidney-only transplantation with no history of lung transplantation (KTx). A total of 270 lung recipients subsequently underwent kidney transplantation (KAL). Regression models demonstrated a lower risk of post-listing mortality for KAL patients compared with 346 lung recipients on the kidney waitlist who never received kidneys (Ploss (Ploss, for KAL patients (P = .86). KAL patients enjoy a significant survival benefit compared with waitlisted lung recipients who do not receive kidneys. However, KAL patients do poorly compared with KTx patients. Decisions about KAL transplantation must be made on a case-by-case basis considering patient and donor factors. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  11. Addiction Risk Low for Seniors Taking Post-Op Opioids

    Science.gov (United States)

    ... explained Dr. Ruchi Sharma. She is a pain management specialist at Winthrop-University Hospital in Mineola, N.Y. However, addiction specialists also ... JAMA Surgery . SOURCES: Ruchi Sharma, M.D., pain management and ... Winthrop-University Hospital, Mineola, N.Y.; Harshal Kirane, M.D., director ...

  12. Comparing two developmental applications of speech technology

    CSIR Research Space (South Africa)

    Sharma Grover, A

    2011-05-01

    Full Text Available stream_source_info Sharma Grover1_2011.pdf.txt stream_content_type text/plain stream_size 6 Content-Encoding ISO-8859-1 stream_name Sharma Grover1_2011.pdf.txt Content-Type text/plain; charset=ISO-8859-1 ...

  13. Identification of Early Response Genes in Human Peripheral Leukocytes Infected with Orientia tsutsugamushi: The Emergent of a Unique Gene Expression Profile for Diagnosis of O. tsutsugamush Infection

    Science.gov (United States)

    2010-01-01

    the inoculum was dispersed uniformly over all the cells. The flasks were incubated at 35 o C with 5% CO2 in M- 199 with Earles salts , 5% fetal bovine...Hyg 2003; 69: 60-6. [7] Sharma A, Mahajan S, Gupta ML, Kanga A, Sharma V. Investigation of an outbreak of scrub typhus in the himalayan region of

  14. Experimentally determined solidi in the Ca-bearing granite system NaAlSi3O8-CaAl2Si2O8-KAlSi3O8-SiO2-H2O-CO2

    Science.gov (United States)

    Bohlen, S.R.; Eckert, J.O.; Hankins, W.B.

    1995-01-01

    The phase relationships of melting of synthetic granite in the presence of an H2O-CO2 fluid were determined. These results provide constraints on the maximum temperatures of regional metamorphism attainable in vapor-saturated metapelitic and quartzofeldspathic rocks that escaped widespread melting. At pressures below 10 kbar, a fluid phase of XH2O = 0.75, 0.5, and 0.25 limits temperatures to below ~700-725, ~800-825, and ~850-875??C, respectively. As a consequence, the formation of granulite does not require CO2 concentrations in a coexisting fluid to exceed an XCO2 of 0.25-0.5. -from Authors

  15. Constructing Control Charts in A Printery Company for Monitoring Paper Thickness and Color Shifts( Bir Basımevinde Kağıt Kalınlığı ve Renk Kaymalarının İzlenmesi İçin Kontrol Kartı Oluşturulması

    Directory of Open Access Journals (Sweden)

    Aşkın ÖZDAĞOĞLU

    2011-01-01

    Full Text Available Assuring the quality of a product is a big problem for all companies. Statistical process control is the main quantitative tool used in TQM. For monitoring the process some statistical process control techniques are used. The most important tool for monitoring the process is quality control chart. Control charts are used in analysis of process changes. Main subject of this study is to construct a quality control chart for offset printing machine in a printery company. Because of the fact that there are some problems in the machines with respect to the color shifting and paper thickness in the output, this study aims at analyzing the production process for decreasing the shifts and the variation in paper thickness. An offset printing machine in the company is selected for constructing the quality control chart. This work focuses on 54*72 Heidelberg offset printing (2 Colors brand printing machine and paper thickness in Advertising and Printing Company.

  16. A Neural Network Learning Algorithm Based on the Extended Kal man Filter Applied to Stock Prediction%基于扩展Kalman滤波的神经网络学习算法在股票预测中的应用

    Institute of Scientific and Technical Information of China (English)

    何芳; 陈收

    2003-01-01

    给出一种新颖的用于股价预测的基于扩展Kalman滤波的神经网络学习算法.与传统的BP算法相比,该方法具有更好的收敛率和学习能力.通过对股票的预测实验验证该方法的可行性和有效性.

  17. The Kinematic Analysis of Zou Kal s Stoop in Shoot And 1/2t. Thr hdst. in Ovgr on Horizontal Bar%邹凯单杠中穿上转体360°经反握倒立动作的运动学分析

    Institute of Scientific and Technical Information of China (English)

    程亮; 常书婉

    2012-01-01

    为了分析邹凯完成单杠“中穿上转体360°经反握倒立”动作的运动学特点,在2012年全国体操锦标赛单杠决赛中,运用三维录像解析法对邹凯完成该动作进行分析,得出运动学参数。在进行运动学技术诊断的同时,把符合体操规则和运动生物力学原理的部分建立运动学技术模型。论证其中运用到的生物力学原理,为广大教练员、运动员提供一些关于邹凯的技术参考数据,也为其他运动员改进技术,丰富单杠运动技术理论起到一定的促进作用。%In order to analyze the kinematic characteristics of stoop in shoot and 1/2t. thr hdst. in ovgr,which is completed by Zou Kai. In the horizontal bar final of the 2012 National Gymnastics Champi- onships, Using three -dimensional video analysis of the connection action from Zou Kai, derived kinematic parameters, carry out a ki- nematics technical diagnosis to Zou Kai's action, and established ki- nematic model by based on the part that be in accordance with the gymnastics rules and Biomechanics Principle. Demonstrated the bio- mechanical principles what have been applied, at the same time, Provided Zou Kai's technical reference data for the majority of coa- ches and athletes, to play a certain advancement role for improving technology for other athletes and rich horizontal bar movement theo- ry.

  18. Bulanık Kazanç Ayarlamalı Nonlineer PI Kontrolörün Kalıcı Mıknatıslı Doğru Akım Motor-Dinamo Sistemine Uygulanması = Applying the Fuzzy Gain Scheduling Nonlinear PI Controller to Permanent Magnet Direct Current Motor - Dynamo System

    Directory of Open Access Journals (Sweden)

    Kamil Burak DALCI

    2004-01-01

    Full Text Available This paper describes the realization of a fuzzy gain scheduling scheme of a PI controller using a RISC microcontroller. Fuzzy rules and reasoning are utilised on-line to determine the PI controller parameters based on the error signal and its first difference. The Fuzzy control algorithm is implemented in the RISC microcontroller to regulate the speed of a permanent magnet DC motor (PMDC and works on-line. The microcontroller directly tunes the motor speed with a chopper converter which changes the motor terminal voltage. Application results demonstrate that better control performance can be achieved in comparison with traditional PI controllers.

  19. İzmir ve Aliağa Körfezinde Mevsimsel Olarak Avlanan Bazı Ekonomik Balık Türlerinde Organik Klorlu Pestisit Kalıntılarının Araştırılması.

    Directory of Open Access Journals (Sweden)

    Belgin H. Uluocak

    2015-12-01

    Full Text Available Bu çalışmada, Aliağa, Foça, Tuzla (Homa, Urla İskele ve Mordoğan’dan dört tür balık (Kefal, Barbun, Çipura, Dil balığı mevsimsel olarak toplanmış ve analize alınmıştır. Balık dokusunda Organik Klorlu (OC pestisitler GC-ECD ile analiz edilmiş ve GCMS ile doğrulanmıştır. Elde edilen bulgulara göre tüm numunelerde OC’lu pestisitlerden DDT nin metaboliti olan DDE bulunmuştur.DDE daha kararlı bir bileşik olup, DDT nin eskiden kullanılmış olduğunu göstermektedir

  20. Atmospheric fine and coarse mode aerosols at different environments of India and the Bay of Bengal during winter-2014: Implications of a coordinated campaign

    Digital Repository Service at National Institute of Oceanography (India)

    Sen, A.; Ahammed, Y.N.; Arya, B.C.; Banerjee, T.; Begam, R.G.; Baruah, B.P.; Chatterjee, A.; Choudhuri, A.K.; Dhir, A.; Das, T.; Dhyani, P.P.; Deb, N.C.; Gadi, R.; Gauns, M.; Ghosh, S.K.; Gupta, A.; Sharma, K.C.; Khan, A.H.; Kumari, K.M.; Kumar, M.; Kumar, A.; Kuniyal, J.C.; Lakhani, A.; Meena, R.K.; Mahapatra, P.S.; Naqvi, S.W.A.; Singh, D.P.; Pal, S.; Panda, S.; Rohtash; Saikia, J.; Saikia, P.; Sharma, A.; Sharma, P.; Saxena, M.; Shenoy, D.M.; Vachaspati, C.V.; Sharma, S.K.; Mandal, T.K

    –12048. [7] M.G. Lawrence, J. Lelieveld, Atmospheric pollutant outflow from southern Asia: a review, Atmos. Chem. Phys. Discuss., 10(4) (2010) 11017–11096. [8] T. Saud, M. Saxena, D.P. Singh, Saraswati, Manisha Dahiya, S.K. Sharma, A. Datta, Ranu Gadi, T.K... aerosols in China and India, Science, 297(5590) (2002) 2250–2253. [10] M.V.S.N. Prasad, C. Sharma, B.C. Arya, T.K. Mandal, S. Singh, M.J. Kulshrestha, R. Agnihotri, S.K. Mishra, S.K. Sharma, Experimental facilities to monitor various types of atmospheric...

  1. Kalirin-7 is necessary for normal NMDA receptor-dependent synaptic plasticity

    KAUST Repository

    Lemtiri-Chlieh, Fouad

    2011-12-19

    Background: Dendritic spines represent the postsynaptic component of the vast majority of excitatory synapses present in the mammalian forebrain. The ability of spines to rapidly alter their shape, size, number and receptor content in response to stimulation is considered to be of paramount importance during the development of synaptic plasticity. Indeed, long-term potentiation (LTP), widely believed to be a cellular correlate of learning and memory, has been repeatedly shown to induce both spine enlargement and the formation of new dendritic spines. In our studies, we focus on Kalirin-7 (Kal7), a Rho GDP/GTP exchange factor (Rho-GEF) localized to the postsynaptic density that plays a crucial role in the development and maintenance of dendritic spines both in vitro and in vivo. Previous studies have shown that mice lacking Kal7 (Kal7 KO) have decreased dendritic spine density in the hippocampus as well as focal hippocampal-dependent learning impairments.Results: We have performed a detailed electrophysiological characterization of the role of Kal7 in hippocampal synaptic plasticity. We show that loss of Kal7 results in impaired NMDA receptor-dependent LTP and long-term depression, whereas a NMDA receptor-independent form of LTP is shown to be normal in the absence of Kal7.Conclusions: These results indicate that Kal7 is an essential and selective modulator of NMDA receptor-dependent synaptic plasticity in the hippocampus. 2011 Lemtiri-Chlieh et al; licensee BioMed Central Ltd.

  2. Kalirin-7 is necessary for normal NMDA receptor-dependent synaptic plasticity

    Directory of Open Access Journals (Sweden)

    Lemtiri-Chlieh Fouad

    2011-12-01

    Full Text Available Abstract Background Dendritic spines represent the postsynaptic component of the vast majority of excitatory synapses present in the mammalian forebrain. The ability of spines to rapidly alter their shape, size, number and receptor content in response to stimulation is considered to be of paramount importance during the development of synaptic plasticity. Indeed, long-term potentiation (LTP, widely believed to be a cellular correlate of learning and memory, has been repeatedly shown to induce both spine enlargement and the formation of new dendritic spines. In our studies, we focus on Kalirin-7 (Kal7, a Rho GDP/GTP exchange factor (Rho-GEF localized to the postsynaptic density that plays a crucial role in the development and maintenance of dendritic spines both in vitro and in vivo. Previous studies have shown that mice lacking Kal7 (Kal7KO have decreased dendritic spine density in the hippocampus as well as focal hippocampal-dependent learning impairments. Results We have performed a detailed electrophysiological characterization of the role of Kal7 in hippocampal synaptic plasticity. We show that loss of Kal7 results in impaired NMDA receptor-dependent LTP and long-term depression, whereas a NMDA receptor-independent form of LTP is shown to be normal in the absence of Kal7. Conclusions These results indicate that Kal7 is an essential and selective modulator of NMDA receptor-dependent synaptic plasticity in the hippocampus.

  3. Browse Title Index - African Journals Online

    African Journals Online (AJOL)

    Items 201 - 250 of 446 ... Vol 8, No 4 (2016), Generalized model for predicting methane conversion to syngas in membrane reactor, Abstract PDF ... P.K. Singhal, R Naresh, V Sharma, G.K. Nadakuditi ... Somticha Panich, Jai Govind Singh.

  4. Determinant of Poverty in Ethiopia

    African Journals Online (AJOL)

    preferred customer

    Teshome Kebede and M. K. Sharma: Determinant of Poverty in Ethiopia. 114. 1. ... share of the population that is multidimensional poor, adjusted by the intensity ... nutrition, as well as clothing, housing and health care and education that can.

  5. Invited paper dedicated to late Prof. M. Tajuddin Phase velocity and ...

    African Journals Online (AJOL)

    user

    M. Tajuddin. Phase velocity and attenuation of plane waves in dissipative elastic media: ... M. D. Sharma. Dept. of Mathematics, Kurukshetra University, INDIA-136 119 ..... Similar will be the situation with alternate iterative relation. ) (1. = x log.

  6. 560-IJBCS-Article-Dr Chandrika N

    African Journals Online (AJOL)

    DR GATSING

    with ferrous sulphate and carbonyl iron in mild iron deficiency anemia ... Maternal mortality continues to be a .... Principle: Non cyanide Hb analysis method, ..... Child.,. 134: 875. Sharma JB. 2003. Progress in obstetrics and gynecology by John ...

  7. Corneal injury

    Science.gov (United States)

    ... Foundations of Clinical Ophthalmology . 2013 ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2013:vol 3; chap 6. Sharma ... EA, eds. Duane's Ophthalmology . 2013 ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2013:vol 5; chap 45. Yanoff ...

  8. Photophobia

    Science.gov (United States)

    ... eds. Duane's Clinical Ophthalmology . 2013 ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2013:vol. 2, chap 16. Godfrey ... eds. Duane's Clinical Ophthalmology . 2013 ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2013:vol. 4, chap 40. Sharma ...

  9. Eye emergencies

    Science.gov (United States)

    ... eds. Duane's Foundations of Clinical Ophthalmology . Philadelphia, PA: Lippincott Williams and Wilkins; 2013:vol. 3, chap 6. ... Practice of Emergency Medicine . 6th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2009:chap 54-61. Sharma R, ...

  10. 2 October 2012 - Egyptian Academy of Scientific Research and Technology President M. Al Sherbiny signing a protocol agreement with CERN Director-General R. Heuer, witnessed by Ambassador to the UN W. Bassim. This signature is followed by the signature of an MoU with ALICE and CMS Collaborations.

    CERN Multimedia

    Maximilien Brice

    2012-01-01

    Where present: ALICE Collaboration: CP. Giubellino, F. Carminati, C. Decosse, and A. N. Tawfik CMS Collaboration: T. Camporesi A. Charkiewicz, A. De Roeck, A. Petrilli, A. Sharma with S. Aly, Y. Assran, M. Attia, R. Masod and A. Radi

  11. Disease: H00722 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available Mutations are identified in KRT9. Mild form of EPPK is linked to KRT1. Skin and c...hgal VN, Sardana K, Sharma S, Raut D Hereditary palmoplantar (epidermolytic) keratoderma: illustration through a familial report. Ski

  12. ENDOSCOPIC TREATMENT OF CHYLURIA USING POVIDONE

    African Journals Online (AJOL)

    IODINE WITH CONTRAST AGENT - A PRELIMINARY EXPERIENCE. G.R. SHARMA AND ... also leads to nutritional deficiency and a state .... risk of renal damage or ureteric strictures using ... parasitic and non parasitic factors can cause.

  13. Biotechnology for Improving Food Security in Rwanda

    African Journals Online (AJOL)

    cntaganda

    workplace, nursery, and green house, and trained manpower. Unfortunately, .... Malaysia and additional income for small growers (Sharma, et al., 2002). In Thailand ... genotypes of diverse groups of plant species (Rani and Raina, 2000). The.

  14. Study of simple sequence repeat (SSR) polymorphism for biotic ...

    African Journals Online (AJOL)

    home

    2013-10-02

    Oct 2, 2013 ... back cross breeding; SSRs, simple sequence repeats; PIC, polymorphism ..... PIC values were reported in barley wheat and rice (Gu et ... doubled-haploid rice population. Theor. ... Grover A, Aishwarya V, Sharma PC (2007).

  15. Genetic analysis of wild and cultivated germplasm of pigeonpea ...

    African Journals Online (AJOL)

    Ezedom Theresa

    Lens sp. (Sharma et al., 1995; Ahmad et al., 1996),. Phaseolus sp. (Beebe et al., 2000; Chiorato et al., 2007), ..... cultivated ICP 7543 and ICP 14144 revealed the highest ... Akkaya MS, Shoemaker RC, Specht JE, Bhagwat AA, Cregan PB.

  16. an analysis of urban irrigation farming and its urban planning ...

    African Journals Online (AJOL)

    DR. AMINU

    integrated into planning processes in the area have been given. .... religious and cultural considerations which discourage ..... Mexico. Research report No. 41.34 p. ISBN 92-9090-404-6. Sharma, R. K., Agrawal, M., and Marshall, F. (2007).

  17. Download this PDF file

    African Journals Online (AJOL)

    GB

    2017-07-01

    Jul 1, 2017 ... management of lung tumors (75.6%). Only 21 (8.4%) of ... Paediatrics) where patients often require .... presented at terminal stage for the procedure coupled .... 15. Sharma D, Newman TG, Aronow WS. Lung cancer screening:.

  18. Pesticide residues in sediments from the west coast of India

    Digital Repository Service at National Institute of Oceanography (India)

    Sarkar, A.; SenGupta, R.

    Realities and Prospects. R. C. Sharma, Rajesh Pub. New Delhi. Thompson, R. E. (1984). Analytical reference standards and sup- plemental data: The pesticides and Industrial chemicals repository. US Environmental Protection Agency, EPA-600/4-84-082. Las...

  19. Evaluation of Lateral-Flow Clostridium botulinum Neurotoxin Detection Kits for Food Analysis

    Science.gov (United States)

    2005-02-08

    samples for each food type (n 3). No mixed results were observed. 3938 SHARMA ET AL. APPL. ENVIRON. MICROBIOL. histolyticum, Clostridium tetani ...of Lateral-Flow Clostridium botulinum Neurotoxin Detection Kits for Food Analysis Shashi K. Sharma,1* Brian S. Eblen,1 Robert L. Bull,2 Donald H. Burr...detecting Clostridium botulinum neuro- toxins (BoNTs) in an assortment of foods were evaluated. Toxin extraction and preparation methods for various liquid

  20. A Brain-Machine-Brain Interface for Rewiring of Cortical Circuitry after Traumatic Brain Injury

    Science.gov (United States)

    2015-11-01

    Sharma, D. B. McCreery, M. Han, and V. Pikov, “Bidirectional telemetry controller for neuroprosthetic devices,” IEEE Trans. Neural Syst. Rehabil. Eng...Circuits and Systems, 4(3), 149–161. 5. Sharma, V., McCreery, D. B., Han, M., & Pikov, V. (2010). Bidirectional telemetry controller for neuroprosthetic...Sheth, H., Felix, S., Delima, T., et al. (2012). Polymer neural interface with dual -sided electrodes for neural stimulation and recording. Conf. Proc

  1. Subduction recycling of continental sediments and the origin of geochemically enriched reservoirs in the deep mantle

    Energy Technology Data Exchange (ETDEWEB)

    Rapp, R.P.; Irifune, T.; Shimizu, N.; Nishiyama, N.; Norman, M.D.; Inoue, T. (Ehime U); (WHOI); (UC); (ANU)

    2008-10-08

    Isotopic and trace element geochemical studies of ocean island basalts (OIBs) have for many years been used to infer the presence of long-lived ({approx} 1-2 Ga old) compositional heterogeneities in the deep mantle related to recycling of crustal lithologies and marine and terrigenous sediments via subduction [e.g., Zindler, A., Hart, S.R., 1986. Chemical geodynamics. Annu. Rev. Earth Planet. Sci. 14, 493-571; Weaver, B.L., 1991. The origin of ocean island basalt end-member compositions: trace element and isotopic constraints. Earth Planet. Sci. Lett. 104, 381-397; Chauvel, C., Hofmann, A.W., Vidal, P., 1992. HIMU-EM: the French Polynesian connection. Earth Planet. Sci. Lett. 110, 99-119; Hofmann, A.W., 1997. Mantle geochemistry: the message from oceanic volcanism. Nature 385, 219-229; Willbold, M., Stracke, A., 2006. Trace element composition of mantle end-members: Implications for recycling of oceanic and upper and lower continental crust. Geochem. Geophys. Geosyst. Q04004. 7, doi:10.1029/2005GC001005]. In particular, models for the EM-1 type ('enriched mantle') OIB reservoir have invoked the presence of subducted, continental-derived sediment to explain high {sup 87}Sr/{sup 86}Sr ratios, low {sup 143}Nd/{sup 144}Nd and {sup 206}Pb/{sup 204}Pb ratios, and extreme enrichments in incompatible elements observed in OIB lavas from, for example, the Pitcairn Island group in the South Pacific [Woodhead, J.D., McCulloch, M.T., 1989; Woodhead, J.D., Devey, C.W., 1993. Geochemistry of the Pitcairn seamounts, I: source character and temporal trends. Earth Planet. Sci. Lett. 116, 81-99; Eisele, J., Sharma, M., Galer, S.J.G., Blichert-Toft, J., Devey, C.W., Hofmann, A.W., 2002. The role of sediment recycling in EM-1 inferred from Os, Pb, Hf, Nd, Sr isotope and trace element systematics of the Pitcairn hotspot. Earth Planet. Sci. Lett. 196, 197-212]. More recently, ultrapotassic, mantle-derived lavas (lamproites) from Gaussberg, Antarctica have been interpreted as

  2. Kuni 16. VIII toimub Loode-Prantsusmaa rannikulinnas Mont-Saint-Michel'is...

    Index Scriptorium Estoniae

    2004-01-01

    Kunstifestival "Quand l'art change la baie" ("Kui kunst merelahte muudab"). Eestist on kutsutud Alice Kask, Kaie Kal, Laurentsius, Peeter Laurits, Mall Nukke, Kadri Kangilaski, Toomas Tõnissoo, kes lisaks maalide eksponeerimisele teevad kohapeal ka heinalinde

  3. Miniature Airborne Methane Sensor Project

    Data.gov (United States)

    National Aeronautics and Space Administration — KalScott Engineering, and the subcontractor, Princeton University propose the development and demonstration of compact and robust methane sensor for small Unmanned...

  4. Majör ortopedik cerrahilerde venöz tromboemboli profilaksisi: Çokmerkezli, prospektif, gözlem çalışması

    National Research Council Canada - National Science Library

    USTAOĞLU, Recep Gür; ŞAVK, Öner; ALTINTAŞ, Faik; ÖZTÜRK, İrfan; ŞİMŞEK, Aykın; BİLGEN, Ömer Faruk; BAYRAM, Hüseyin; GÖĞÜŞ, Abdullah; ATİLLA, Bülent; ÖZİÇ, Uğur; DABAK, Nevzat; ERDEMLİ, Bülent; GÜRBÜZ, Hakan; KINIK, Hakan; PESTİLCİ, Fatih; SERİN, Erhan; TÖZÜN, Remzi; ÖNDER, Çetin; ARGÜN, Mahmut; MEMİK, Recep; KONAL, Adnan; AKGÜN, Işık

    2008-01-01

    ... çalışmaya alındı. Olguların 316'sında (%35.2) total kalça protezi (TKP), 328'inde (%36.5) total diz protezi (TDP), 255'inde (%28.4) kalça kırığı (KK) cerrahisi uygulandı. Tüm hastalarda farmakolojik DVT profilaksisine...

  5. The Effect of Fluorocarbon Surfactant Additives on the Effective Viscosity of Acetone Solutions of Cellulose Diacetate,

    Science.gov (United States)

    2014-09-26

    34 FOREIGN TECHNOLOGY DIVISION i00 Lfl .. THE EFFECT OF FLUOROCARBON SURFACTANT ADDITIVES ON THE EFFECTIVE VISCOSITY OF ACETONE SOLUTIONS OF CELLULOSE ...ADDITIVES ON TH~ .. t- ’_ ition EFFECTIVE VISCOSITY OF ACETONE SOLUTIONS OF CELLULOSE DIACETATE D~rbt~l By: L.A. Shits, N. Yu. Kal’nova Codesuton English...VISCOSITY OF ACETONE SOLUTIONS OF CELLULOSE DIACETATE L. A. Shits, N. Yu. Kal’nova (Institute of Physical Chemistry of the AS USSR, Moscow) ! - The

  6. KOMPOSISI ZAT GIZI MAKANAN SIAP SANTAP BERBAGAI HIDANGAN NASI/MIE LENGKAP DAN PENGANAN KHAS INDONESIA

    Directory of Open Access Journals (Sweden)

    Dewi Sabita Slamet

    2012-11-01

    Full Text Available Pada tahun anggaran 1989/1990 telah diteliti komposisi zat gizi 14 masakan (mie, dll dan 10 makanan penganan (jajanan. Kandungan zat gizi jenis-jenis masakan berkisar antara 60-291 Kal dengan protein berkisar antara 0.85-15.6 g. Kandungan kalori jenis-jenis penganan berkisar antara 93-310 Kal, dan kandungan protein jenis penganan ini berkisar antara 0.70-8.0 g.

  7. Kalirin Binds the NR2B Subunit of the NMDA Receptor, Altering Its Synaptic Localization and Function

    KAUST Repository

    Kiraly, D. D.

    2011-08-31

    The ability of dendritic spines to change size and shape rapidly is critical in modulating synaptic strength; these morphological changes are dependent upon rearrangements of the actin cytoskeleton. Kalirin-7 (Kal7), a Rho guanine nucleotide exchange factor localized to the postsynaptic density (PSD), modulates dendritic spine morphology in vitro and in vivo. Kal7 activates Rac and interacts with several PSD proteins, including PSD-95, DISC-1, AF-6, and Arf6. Mice genetically lacking Kal7 (Kal7KO) exhibit deficient hippocampal long-term potentiation (LTP) as well as behavioral abnormalities in models of addiction and learning. Purified PSDs from Kal7KO mice contain diminished levels of NR2B, an NMDA receptor subunit that plays a critical role in LTP induction. Here we demonstrate that Kal7KO animals have decreased levels of NR2B-dependent NMDA receptor currents in cortical pyramidal neurons as well as a specific deficit in cell surface expression of NR2B. Additionally, we demonstrate that the genotypic differences in conditioned place preference and passive avoidance learning seen in Kal7KO mice are abrogated when animals are treated with an NR2B-specific antagonist during conditioning. Finally, we identify a stable interaction between the pleckstrin homology domain of Kal7 and the juxtamembrane region of NR2B preceding its cytosolic C-terminal domain. Binding of NR2B to a protein that modulates the actin cytoskeleton is important, as NMDA receptors require actin integrity for synaptic localization and function. These studies demonstrate a novel and functionally important interaction between the NR2B subunit of the NMDA receptor and Kalirin, proteins known to be essential for normal synaptic plasticity.

  8. Inhibition of angiogenesis and HCT-116 xenograft tumor growth in mice by kallistatin

    Institute of Scientific and Technical Information of China (English)

    Yong Diao; Rui-An Xu; Jian Ma; Wei-Dong Xiao; Jia Luo; Xin-Yan Li; Kin-Wah Chu; Peter WC Fung; Nagy Habib; Farzin Farzaneh

    2007-01-01

    AIM: To investigate the inhibitory effect of kallistatin (KAL) on angiogenesis and HCT-116 xenograft tumor growth.METHODS: Heterotopic tumors were induced by subcutaneous injection of 2 × 106 HCT-11 cells in mice.Seven days later, 2 × 1011 rAAV-GFP or rAAV-KAL was injected intratumorally (n = 5 for each group). The mice were sacrificed at d 28, by which time the tumors in the rAAV-GFP group had grown to beyond 5% of the total body weight. Tumor growth was measured by calipers in two dimensions. Tumor angiogenesis was determined with tumor microvessel density (MVD) by immunohistology. Tumor cell proliferation was assessed by Ki-67 staining.RESULTS: Intratumor injection of rAAV-KAL inhibited tumor growth in the treatment group by 78% (171 ±52 mm3) at d 21 after virus infection compared to the control group (776 ± 241 mm3). Microvessel density was significantly inhibited in tumor tissues treated with rAAV-KAL. rAAV-KAL also decreased the proportion of proliferating cells (Ki-67 positive cells) in tumors compared with the control group.CONCLUSION: rAAV-mediated expression of KAL inhibits the growth of colon cancer by reducing angiogenesis and proliferation of tumor cells, and may provide a promising anti-angiogenesis-based approach to the treatment of metastatic colorectal cancer.

  9. Immunomodulatory Role of an Ayurvedic Formulation on Imbalanced Immunometabolics during Inflammatory Responses of Obesity and Prediabetic Disease

    Directory of Open Access Journals (Sweden)

    Kamiya Tikoo

    2013-01-01

    Full Text Available Kal-1 is a polyherbal decoction of seven different natural ingredients, traditionally used in controlling sugar levels, inflammatory conditions particularly regulating metabolic and immunoinflammatory balance which are the major factors involved in obesity and related diseases. In the present study, we aimed to investigate the effect of Kal-1 (an abbreviation derived from the procuring source on diet-induced obesity and type II diabetes using C57BL/6J mice as a model. The present study was performed with two experimental groups involving obese and prediabetic mice as study animals. In one, the mice were fed on high-fat with increased sucrose diet, and different amounts (5, 20, and 75 μL of Kal-1 were administered with monitoring of disease progression over a period of 21 weeks whereas in the second group the mice were first put on the same diet for 21 weeks and then treated with the same amounts of Kal-1. A significant reduction in body weight, fat pads, fasting blood glucose levels, insulin levels, biochemical parameters, immunological parameters, and an array of pro- and anticytokines was observed in obese and diabetic mice plus Kal-1 than control (lean mice fed on normal diet. In conclusion, Kal-1 has immunomodulatory potential for diet-induced obesity and associated metabolic disorders.

  10. Renal abnormalities in patients with Kallmann syndrome.

    Science.gov (United States)

    Zenteno, J C; Méndez, J P; Maya-Núñez, G; Ulloa-Aguirre, A; Kofman-Alfaro, S

    1999-03-01

    To report experience in patients with Kallmann syndrome (KS) in whom urography was used to establish the type and frequency of renal anomalies associated with the disorder. Of 19 patients with KS, 15 had the X-linked recessive form of the disease, whereas the remaining four were sporadic. Each patient underwent intravenous pyelography (IVP) using a non-ionic, low osmolarity contrast medium. Of the 19 patients with KS, 10 had kidney abnormalities; four presented with unilateral renal agenesis and six had less severe forms of renal abnormality (renal malrotation in four and bilateral dilatation of the calyces and pelves in two). One of the patients with unilateral renal agenesis carried a deletion in KAL, the gene responsible for the X-linked type of KS. Three of the four patients with renal malrotation had a confirmed X-linked recessive form and one carried a point mutation in KAL. These results suggest that kidney abnormalities are more frequent and diverse in patients with KS than previously reported. They also indicate that defects in the KAL gene may contribute to abnormal renal development. However, a review of the literature revealed no close correlation between KAL mutations and kidney anomalies in the X-linked type of disease. Taken together, these data suggest that KAL mutations are not invariably associated with failure of renal development and that additional factors (epigenetic or local) may compensate for defects in the KAL protein.

  11. Studies on Sono-Chemical Biodiesel Production Using Smoke Deposited Nano MgO Catalyst

    Directory of Open Access Journals (Sweden)

    P. Sivakumar

    2013-12-01

    Full Text Available The comprehensive study of smoke deposited nano sized MgO as a catalyst for biodiesel production was investigated. The transesterification reaction was studied under constant ultrasonic mixing for different parameters like catalyst quantity, methanol oil molar ratio, reaction temperature and reaction time. An excellent result of conversion was obtained at 1.5 wt% catalyst; 5:1 methanol oil molar ratio at 55°C, a conversion of 98.7% was achieved after 45 min. The conversion was three to five times higher than those are reported for laboratory MgO in literature. This was mainly due to the enhancement of surface area of the catalyst and the activity of ultrasonic waves. Catalyst is easily recovered and reused up to eight times with easy regeneration steps.  © 2013 BCREC UNDIP. All rights reservedReceived: 18th March 2013; Revised: 20th August 2013; Accepted: 9th September 2013[How to Cite: Sivakumar, P., Sankaranarayanan, S., Renganathan, S., Sivakumar, P. (2013. Studies on Sono-Chemical Biodiesel Production Using Smoke Deposited Nano MgO Catalyst. Bulletin of Chemical Re-action Engineering & Catalysis, 8 (2: 89-96.(doi:10.9767/bcrec.8.2.4628.89-96][Permalink/DOI: http://dx.doi.org/10.9767/bcrec.8.2.4628.89-96

  12. VAKUM VE ISI İLE ŞEKİL VERİLEN BİR ÜRÜNDE KARŞILAŞTIRMALI KALINLIK DAĞILIMI TESPİTİ

    Directory of Open Access Journals (Sweden)

    Olcay EKŞİ

    2013-12-01

    Full Text Available Bu çalışmada, vakum ve ısı ile şekil verilen bir ürünün kalınlık dağılımı tespiti karşılaştırmalı olarak belirlenmiştir. Ürün kalınlık dağılımı ilkin proses simülasyonu vasıtasıyla icra edilmiştir. Buna ek olarak, Alansal Çekme Oranı(Areal Draw Ratio kullanılarak ürün kalınlık profili oluşturulmuştur. Elde edilen iki farklı kalınlık dağılımı karşılaştırmalı olarak incelenmiştir. Üretim süreci simülasyonu, kullanılan polimer malzeme özelliklerini ve proses parametrelerini içermekte buna karşın Alansal Çekme Oranı(A.D.R. ile kalınlık tespiti malzeme özelliklerinden bağımsız sadece kalıp veya ürün geometrisine göre sonuç vermektedir. Sonuç olarak; Alansal Çekme Oranı ile tespit edilen kalınlık dağılımı simülasyon vasıtasıyla elde edilen kalınlık dağılımıyla farklı sonuçlar ortaya koymuştur. Ancak her iki metot ile elde edilen en ince cidar kalınlık değeri aynı noktalar arasını göstermektedir. Alansal Çekme Oranının, hassas bir kalınlık dağılımı ifadesinin oluşturulmasında değil ürünün en ince ya da en zayıf olduğu noktanın tespitinde kullanılmasının uygun olacağı sonucuna varılmıştır.

  13. The Rho-GEF Kalirin regulates bone mass and the function of osteoblasts and osteoclasts.

    Science.gov (United States)

    Huang, Su; Eleniste, Pierre P; Wayakanon, Kornchanok; Mandela, Prashant; Eipper, Betty A; Mains, Richard E; Allen, Matthew R; Bruzzaniti, Angela

    2014-03-01

    Bone homeostasis is maintained by the balance between bone resorption by osteoclasts and bone formation by osteoblasts. Dysregulation in the activity of the bone cells can lead to osteoporosis, a disease characterized by low bone mass and an increase in bone fragility and risk of fracture. Kalirin is a novel GTP-exchange factor protein that has been shown to play a role in cytoskeletal remodeling and dendritic spine formation in neurons. We examined Kalirin expression in skeletal tissue and found that it was expressed in osteoclasts and osteoblasts. Furthermore, micro-CT analyses of the distal femur of global Kalirin knockout (Kal-KO) mice revealed significantly reduced trabecular and cortical bone parameters in Kal-KO mice, compared to WT mice, with significantly reduced bone mass in 8, 14 and 36week-old female Kal-KO mice. Male mice also exhibited a decrease in bone parameters but not to the level seen in female mice. Histomorphometric analyses also revealed decreased bone formation rate in 14week-old female Kal-KO mice, as well as decreased osteoblast number/bone surface and increased osteoclast surface/bone surface. Consistent with our in vivo findings, the bone resorbing activity and differentiation of Kal-KO osteoclasts was increased in vitro. Although alkaline phosphatase activity by Kal-KO osteoblasts was increased in vitro, Kal-KO osteoblasts showed decreased mineralizing activity, as well as decreased secretion of OPG, which was inversely correlated with ERK activity. Taken together, our findings suggest that deletion of Kalirin directly affects osteoclast and osteoblast activity, leading to decreased OPG secretion by osteoblasts which is likely to alter the RANKL/OPG ratio and promote osteoclastogenesis. Therefore, Kalirin may play a role in paracrine and/or endocrine signaling events that control skeletal bone remodeling and the maintenance of bone mass.

  14. Polyphenols from Artemisia annua L Inhibit Adhesion and EMT of Highly Metastatic Breast Cancer Cells MDA-MB-231.

    Science.gov (United States)

    Ko, Young Shin; Lee, Won Sup; Panchanathan, Radha; Joo, Young Nak; Choi, Yung Hyun; Kim, Gon Sup; Jung, Jin-Myung; Ryu, Chung Ho; Shin, Sung Chul; Kim, Hye Jung

    2016-07-01

    Recent evidence suggests that polyphenolic compounds from plants have anti-invasion and anti-metastasis capabilities. The Korean annual weed, Artemisia annua L., has been used as a folk medicine for treatment of various diseases. Here, we isolated and characterized polyphenols from Korean A. annua L (pKAL). We investigated anti-metastatic effects of pKAL on the highly metastatic MDA-MB-231 breast cancer cells especially focusing on cancer cell adhesion to the endothelial cell and epithelial-mesenchymal transition (EMT). Firstly, pKAL inhibited cell viability of MDA-MB-231 cells in a dose-dependent manner, but not that of human umbilical vein endothelial cells (ECs). Polyphenols from Korean A. annua L inhibited the adhesion of MDA-MB-231 cells to ECs through reducing vascular cell adhesion molecule-1 expression of MDA-MB-231 and ECs, but not intracellular adhesion molecule-1 at the concentrations where pKAL did not influence the cell viability of either MDA-MB-231 cells nor EC. Further, pKAL inhibited tumor necrosis factor-activated MDA-MB-231 breast cancer cell invasion through inhibition of matrix metalloproteinase-2 and matrix metalloproteinase-9 and EMT. Moreover, pKAL inhibited phosphorylation of Akt, but not that of protein kinase C. These results suggest that pKAL may serve as a therapeutic agent against cancer metastasis at least in part by inhibiting the cancer cell adhesion to ECs through suppression of vascular cell adhesion molecule-1 and invasion through suppression of EMT. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

  15. The genus Macroteleia Westwood (Hymenoptera, Platygastridae s. l., Scelioninae from China

    Directory of Open Access Journals (Sweden)

    Chen Huayan

    2013-05-01

    Full Text Available The genus Macroteleia Westwood (Hymenoptera: Platygastridae s. l., Scelioninae from China is revised. Seventeen species are recognized based on 502 specimens, all of which are new records for China. Seven new species are described: M. carinigena sp. n. (China, M. flava sp. n. (China, M. gracilis sp. n. (China, M. salebrosa sp. n. (China, M. semicircula sp. n. (China, M. spinitibia sp. n. (China and M. striatipleuron sp. n. (China. Ten species are redescribed: M. boriviliensis Saraswat (China, India, Thailand, M. crawfordi Kiefer, stat. n. (China, Philippines, Thailand, Vietnam, M. dolichopa Sharma (China, India, Vietnam, M. emarginata Dodd (China, Malaysia, M. indica Saraswat & Sharma (China, India, Vietnam, M. lamba Saraswat & Sharma (China, India, Thailand, Vietnam, M. livingstoni Saraswat (China, India, M. peliades Kozlov & Lê (China, Vietnam, M. rufa Szelényi (China, Egypt, Georgia, Russia, Thailand, Ukraine and M. striativentris Crawford (China, Philippines, Thailand, Vietnam. The following five new synonyms are proposed: M. crates Kozlov & Lê syn. n. and M. demades Kozlov & Lê syn. n. of M. crawfordi Kieffer; M. cebes Kozlov & Lê syn. n. and M. dones Kozlov & Lê syn. n. of M. indica Saraswat & Sharma; M. dores Kozlov & Lê syn. n. of M. lamba Saraswat & Sharma. A key to the Chinese species of the genus is provided.

  16. Kallmann syndrome and deafness: an uncommon combination: A case report and a literature review

    Science.gov (United States)

    Salama, Nader

    2016-01-01

    Background: Kallmann syndrome (Kal S) is an isolated form of hypogonadotrophic hypogonadism in combination with a defect in smell sensation. Depending on the genetic form of the disease, a number of non-reproductive, non-olfactory abnormalities may also be existent. In the present report, we describe a male with Kal S associated with hearing loss, and the successful treatment of his sexual and reproductive defects. Case: A 23-year-old Caucasian man presented with a lifelong lack of erection and ejaculation. The patient reported also anosmia combined with loss of hearing ability. A diagnostic work-up identified the presence of Kal S associated with sensorineural hearing loss. Administration of gonadotrophins regained the erection and a viable-sperm containing ejaculation. Conclusion: Lack of erection and ejaculation are important components of delayed puberty which could lead to diagnosis of Kal S. The existence of a hearing impairment in the reported patient makes the recommendation to screen the hearing ability in Kal S of utmost importance. PMID:27679830

  17. Isolation and purification of a new kalimantacin/batumin-related polyketide antibiotic and elucidation of its biosynthesis gene cluster.

    Science.gov (United States)

    Mattheus, Wesley; Gao, Ling-Jie; Herdewijn, Piet; Landuyt, Bart; Verhaegen, Jan; Masschelein, Joleen; Volckaert, Guido; Lavigne, Rob

    2010-02-26

    Kal/bat, a polyketide, isolated to high purity (>95%) is characterized by strong and selective antibacterial activity against Staphylococcus species (minimum inhibitory concentration, 0.05 microg/mL), and no resistance was observed in strains already resistant to commonly used antibiotics. The kal/bat biosynthesis gene cluster was determined to a 62 kb genomic region of Pseudomonas fluorescens BCCM_ID9359. The kal/bat gene cluster consists of 16 open reading frames (ORF), encoding a hybrid PKS-NRPS system, extended with trans-acting tailoring functions. A full model for kal/bat biosynthesis is postulated and experimentally tested by gene inactivation, structural confirmation (using NMR spectroscopy), and complementation. The structural and microbiological study of biosynthetic kal/bat analogs revealed the importance of the carbamoyl group and 17-keto group for antibacterial activity. The mechanism of self-resistance lies within the production of an inactive intermediate, which is activated in a one-step enzymatic oxidation upon export. The genetic basis and biochemical elucidation of the biosynthesis pathway of this antibiotic will facilitate rational engineering for the design of novel structures with improved activities. This makes it a promising new therapeutic option to cope with multidrug-resistant clinical infections. Copyright 2010 Elsevier Ltd. All rights reserved.

  18. Results on n-tupled fixed points in complete asymptotically regular metric spaces

    Directory of Open Access Journals (Sweden)

    Anupam Sharma

    2014-10-01

    Full Text Available The notion of n-tupled fixed point is introduced by Imdad, Soliman, Choudhury and Das, Jour. of Operators, Vol. 2013, Article ID 532867. In this manuscript, we prove some n-tupled fixed point theorems (for even n for mappings having mixed monotone property in partially ordered complete asymptotically regular metric spaces. Our main theorem improves the corresponding results of Imdad, Sharma and Rao (M. Imdad, A. Sharma, K.P.R. Rao, Generalized n-tupled fixed point theorems for nonlinear contractions, preprint.

  19. Molecular Profiles for Lung Cancer Pathogenesis and Detection in US Veterans

    Science.gov (United States)

    2011-10-01

    inflammation and lung cancer risk in cigarette smokers. Inhal Toxicol 2006;18:667-677 63. Dubinett SM, Sharma S, Huang M, Dohadwala M, Pold M, Mao JT...L, et al. COX-2-dependent stabilization of survivin in non- small cell lung cancer. FASEB J. 2004;18:206-208 76. Pold M, Krysan K, Pold A, et al...Annual Report: Reporting Period 20 Sept 2010 – 19 Sept 2011 48 78. Pold M, Zhu LX, Sharma S, et al. Cyclooxygenase-2-dependent expression

  20. The electronic structure and optical properties of ABP 2O 7 ( A = Na, Li) double phosphates

    Science.gov (United States)

    Hizhnyi, Yu. A.; Oliynyk, A.; Gomenyuk, O.; Nedilko, S. G.; Nagornyi, P.; Bojko, R.; Bojko, V.

    2008-01-01

    Partial densities of states and reflection spectra of NaAlP 2O 7, KAlP 2O 7 and LiInP 2O 7 double phosphate crystals are calculated by the full-potential linear-augmented-plane-wave (FLAPW) method. Experimental reflection spectra of KAlP 2O 7, CsAlP 2O 7 and NaInP 2O 7 are measured in the 4-20 eV energy range. The values of band gaps, Eg, are found from a comparison of experiment and calculations to be 6.0 eV for NaAlP 2O 7 and KAlP 2O 7, and 4.6 eV for LiInP 2O 7.

  1. Kaliophilite from fly ash: synthesis, characterization and stability

    Indian Academy of Sciences (India)

    Yao Zhitong; Xia Meisheng; Ye Ying; Zhang Lu

    2011-12-01

    Kaliophilite was synthesized by fusion method using fly ash as starting material. In this method, at first, alkaline fusion of fly ash with KOH occurs, followed by hydrothermal treatment in KOH medium. Scanning electron microscopy (SEM) observations revealed that the synthesized kaliophilite (S-KAL) was a plate-like crystal. X-ray diffraction (XRD) results showed three characteristic diffraction peaks located at 2 = 19.56°, 20.78° and 28.71°, respectively. The thermal analysis indicated that the S-KAL had remarkable thermal stability when heated to 1000°C. Leaching test confirmed the high retention rate of potassium for S-KAL in boiling water for 10 h.

  2. Commentary on "common genetic polymorphisms modify the effect of smoking on absolute risk of bladder cancer." Garcia-Closas M, Rothman N, Figueroa JD, Prokunina-Olsson L, Han SS, Baris D, Jacobs EJ, Malats N, De Vivo I, Albanes D, Purdue MP, Sharma S, Fu YP, Kogevinas M, Wang Z, Tang W, Tardón A, Serra C, Carrato A, García-Closas R, Lloreta J, Johnson A, Schwenn M, Karagas MR, Schned A, Andriole G Jr., Grubb R 3rd, Black A, Gapstur SM, Thun M, Diver WR, Weinstein SJ, Virtamo J, Hunter DJ, Caporaso N, Landi MT, Hutchinson A, Burdett L, Jacobs KB, Yeager M, Fraumeni JF Jr., Chanock SJ, Silverman DT, Chatterjee N, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.: Cancer Res 2013;73(7):2211-20 [Epub 2013 Mar 27].

    Science.gov (United States)

    Scherr, Douglas S

    2014-02-01

    Bladder cancer results from the combined effects of environmental and genetic factors, smoking being the strongest risk factor. Evaluating absolute risks resulting from the joint effects of smoking and genetic factors is critical to assess the public health relevance of genetic information. Analyses included up to 3,942 cases and 5,680 controls of European background in seven studies. We tested for multiplicative and additive interactions between smoking and 12 susceptibility loci, individually and combined as a polygenic risk score (PRS). Thirty-year absolute risks and risk differences by levels of the PRS were estimated for U.S. males aged 50 years. Six of 12 variants showed significant additive gene-environment interactions, most notably NAT2 (P = 7×10(-4)) and UGT1A6 (P = 8×10(-4)). The 30-year absolute risk of bladder cancer in U.S. males was 6.2% for all current smokers. This risk ranged from 2.9% for current smokers in the lowest quartile of the PRS to 9.9% for current smokers in the upper quartile. Risk difference estimates indicated that 8,200 cases would be prevented if elimination of smoking occurred in 100,000 men in the upper PRS quartile compared with 2,000 cases prevented by a similar effort in the lowest PRS quartile (P(additive) = 1×10(-4)). Thus, the potential impact of eliminating smoking on the number of bladder cancer cases prevented is larger for individuals at higher than lower genetic risk. Our findings could have implications for targeted prevention strategies. However, other smoking-related diseases, as well as practical and ethical considerations, need to be considered before any recommendations could be made. Copyright © 2014 Elsevier Inc. All rights reserved.

  3. Complex cooperative functions of heparan sulfate proteoglycans shape nervous system development in Caenorhabditis elegans.

    Science.gov (United States)

    Díaz-Balzac, Carlos A; Lázaro-Peña, María I; Tecle, Eillen; Gomez, Nathali; Bülow, Hannes E

    2014-08-05

    The development of the nervous system is a complex process requiring the integration of numerous molecular cues to form functional circuits. Many cues are regulated by heparan sulfates, a class of linear glycosaminoglycan polysaccharides. These sugars contain distinct modification patterns that regulate protein-protein interactions. Misexpressing the homolog of KAL-1/anosmin-1, a neural cell adhesion molecule mutant in Kallmann syndrome, in Caenorhabditis elegans causes a highly penetrant, heparan sulfate-dependent axonal branching phenotype in AIY interneurons. In an extended forward genetic screen for modifiers of this phenotype, we identified alleles in new as well as previously identified genes involved in HS biosynthesis and modification, namely the xylosyltransferase sqv-6, the HS-6-O-sulfotransferase hst-6, and the HS-3-O-sulfotransferase hst-3.2. Cell-specific rescue experiments showed that different HS biosynthetic and modification enzymes can be provided cell-nonautonomously by different tissues to allow kal-1-dependent branching of AIY. In addition, we show that heparan sulfate proteoglycan core proteins that carry the heparan sulfate chains act genetically in a highly redundant fashion to mediate kal-1-dependent branching in AIY neurons. Specifically, lon-2/glypican and unc-52/perlecan act in parallel genetic pathways and display synergistic interactions with sdn-1/syndecan to mediate kal-1 function. Because all of these heparan sulfate core proteins have been shown to act in different tissues, these studies indicate that KAL-1/anosmin-1 requires heparan sulfate with distinct modification patterns of different cellular origin for function. Our results support a model in which a three-dimensional scaffold of heparan sulfate mediates KAL-1/anosmin-1 and intercellular communication through complex and cooperative interactions. In addition, the genes we have identified could contribute to the etiology of Kallmann syndrome in humans.

  4. Õnnitlused Vabariigi Presidendile ja eesti rahvale Eesti Vabariigi 75. aastapäeva puhul

    Index Scriptorium Estoniae

    1993-01-01

    Boriss Jeltsin, kuninganna Elisabeth, kuninganna Margrethe, kuningas Carl Gustaf, M. Koivisto, Th. Klestil (Austria Vabariigi Liidupresident), Yang Shangkun (Hiina Rahvavabariigi President), Shanker Daval Sharma, kuningas Baudouin, A. Ogi (Šveitsi Konföderatsiooni President), kuningas Harald, patriarh Aleksius. Ilmunud ka: Päevaleht 26. veebr. lk. 1

  5. Polypeptides Based Molecular Electronics

    Science.gov (United States)

    2008-10-06

    shows the condensation reaction of silanes onto silicon substrate [26]. The silanes are reversibly physisorbed onto the hydrated silicon substrate...Introduction of alkene functionality into Proteins in-vivo, FEBS Letters 428 (1998) 68. 30. N. Sharma, R. Furter, P. Kast, D. A. Tirrell, Efficient

  6. 48 - 52_Bauchi et al.

    African Journals Online (AJOL)

    User

    health problems in many parts of the world. It is a ... solution of 70% ethyl alcohol and allowed to dry ..... Poisoning Crisis is 'worst in modern history'. ... enzymatic bioassay. Res. Microbial.,160(2):99-106. Sharma PC,Yelne MB, and Dennis TJ.

  7. Sup(10)Be variation in surficial sediments of the Central Indian Basin

    Digital Repository Service at National Institute of Oceanography (India)

    Nath, B.N.; Aldahan, A.; Possnert, G.; Selvaraj, K.; Mascarenhas-Pereira, M.B.L.; Chen, C.T.A.

    , Geochim. Cosmo- chim. Acta 60 (1996) 213. [8] V.K. Banakar, S.M. Gupta, V.K. Padmavathi, Mar. Geol. 96 (1991) 167. [9] D.V. Borole, Deep-Sea Res. 40 (1993) 761. [10] B.L.K. Somayajulu, P. Sharma, J. Beer, G. Bonani, H.J. Hofmann, E. Morenzoni, M. Nessi, M...

  8. Disease: H00805 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available 0519] ICD-10: H35.5 OMIM: 108300 604841 193230 143200 267750 268100 193220 PMID:18309337 Edward...D:18179896 Hejtmancik JF, Jiao X, Li A, Sergeev YV, Ding X, Sharma AK, Chan CC, Medina I, Edwards AO Mutatio

  9. December 2002 EAST AFRICAN MEDICAL JOURNAL 633

    African Journals Online (AJOL)

    2002-12-12

    Dec 12, 2002 ... with malaria. The specimens were cultured and antibiotic sensitivity done using standard ..... this figure of 50% is taken as the upper limit of isolation of NTS, it .... Elliot, E.J., Sharma, A., Price, B11 and Walker-Smith, J.A..

  10. A comparative study of conservative and surgical management of ...

    African Journals Online (AJOL)

    Arun Kumar Agnihotri

    complications of varicose veins and its rate of recurrence with the treatment undergone by the patient in short ... patients in total developed some kind of complication on the post-treatment part. No .... nature and did not require any additional treatment and did not ... We wish to express our thanks to Dr. R. K. Sharma,. Dean ...

  11. QTL Information Table: 767 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available erval RIL Pusa 1121 Pusa 1342 A RM1812 RM209 pha Amarawathi, Y., Singh, R., Singh, A.K., Singh, V.P., Mohapa...tra, T., Sharma, T.R., and Singh, N.K. (2007). Mapping of quantitative trait loci for basmati quality traits in rice ( Oryza sativa L.) Molecular Breeding. ...

  12. Effects of radiation on switchable gratings and CdSe/ZnS nanostructures

    Science.gov (United States)

    Sharma, S. C.; Ramsey, R. A.; Murphree, J.; Chakraborty, T.; Shive, C.

    2008-10-01

    Switchable gratings formed in Polymer-Dispersed Liquid Crystals (PDLCs) and CdSe/ZnS quantum dots are of interest from scientific and technological points of views[1,2].The Bragg reflection and transmission PDLC gratings can be switched on/off by external fields. We present new results on the effects of synthesis parameters and radiation on the forward/reverse-mode gratings and PL spectra of CdSe/ZnS quantum dots. The PL emission from these nanostructures changes as a result of simultaneous irradiation by 532-nm laser and gamma-rays. The results of this study reaffirm the role of radiation-induced charges in modifying thin films, such as the ones studied in this work containing CdSe/ZnS nanostructures and switchable diffractive elements formed in PDLCs[3]. [1] T. J. Bunning, L. V. Natarajan, V. P. Tondiglia, R. L. Sutherland, Ann. Rev. Mat. Sci. 30, 83 (2000), [2] R. A. Ramsey and S. C. Sharma, Opt. Lett. 30, 592-594 (2005); S. C. Sharma, J. Murphree, T. Chakraborty, J. Lumin. 128, 1771,(2008); R. A. Ramsey and S. C. Sharma, Appl. Phys. B (in press)., [3] S. C. Sharma, L. Zhang, A. J. Tapiawala, P. C. Jain, Phys. Rev. Letts. 87, 105501 (2001).

  13. Estrogen and the Dietary Phytoestrogen Resveratrol as Regulators of the Rho GTPase Rac in Breast Cancer Research

    Science.gov (United States)

    2009-06-01

    findi ngs cont a i ned i n thi s repor t are t hose of the autho r (s) and should not be construed as an off ici a l Department of t he Army position...Singh RP, Tyagi A, Sharma G, Mohan S, Agarwal R (2008) Oral silibinin inhibits in vivo human bladder tumor xenograft growth involving down regulation of

  14. Fatty Acid Synthase Activity as a Target for c-Met Driven Prostate Cancer

    Science.gov (United States)

    2013-07-01

    Sharma, and H.E. Bazan , Association of protein tyrosine phosphatases (PTPs)-1B with c-Met receptor and modulation of corneal epithelial wound healing...Luteolin Post-Transcriptionally Downregulates c-Met Expression Independent of Proteosomal/Lysosomal Degradation. Mol. Cancer. Ther. 2009 Jan 1; 8(1

  15. Eluviisi mõjust haigusele / Lilian Hankewitz

    Index Scriptorium Estoniae

    Hankewitz, Lilian

    2004-01-01

    Raamatu "Vähi vastu aitab see, kui me ei anna talle võimalust tekkidagi" autorid meditsiinidoktor Hari Sharma, ayurveda arst Rama Mishra ja dr. James Meade'i annavad nõu haigusvaenuliku pinnase loomises ja inimese organismi tugevdamises. Järgneb 19.,26. okt., 2., 9.,16.,23.,30. nov., 7.,14.,21. dets.

  16. Storage Stability of Jet Fuel Not Containing Anti-Oxidant (AO)

    Science.gov (United States)

    2012-01-31

    tertiary alkyl groups are not as effective as one methyl and one tertiary butyl. 2. Sharma, B.K., Perez, J.M., Erhan, S.V., “Soybean Oil-Based... Kerosene Fuels,” Proceedings of 2nd International Conference on Long Term Storage Stability of Liquid Fuels, Stavinoha, L.L., Southwest Research Institute

  17. Chapter Twelve

    African Journals Online (AJOL)

    User

    dissemination in Nigeria· Some local jingles from Radio Nigeria Purity F.M. .... Indigenous Language in Advertisement: Problems and Prospects – Thecla ... the rural newspapers from performing their role of rural development· The ..... Sharma Raman, M· and, S (2004), Technical Communication Principle and Practice· India:.

  18. Topological Insulators and Superconductors for Innovative Devices

    Science.gov (United States)

    2015-03-20

    and Technology (OIST), Okinawa, May 14, 2014. 6. Yoichi Ando, “Superconducting Topological Insulators”, Theo Murphy International Scientific...D.; Hor, Y. S.; Cava, R. J.; Hasan, M. Z. Nat. Phys. 2009, 5, 398−402. (20) Dash, S. P.; Sharma, S.; Patel, R. S.; Jong, M. P.; Jansen , R. Nature

  19. Do Stemhagen, Reich, and Muth Have Ears to Hear and Eyes to See? Toward the Subaltern and Counternarratives in Curriculum Studies

    Science.gov (United States)

    Malewski, Erik

    2013-01-01

    In this essay, I offer a response to Stemhagen, Reich, and Muth's (see EJ1089246) delineation of disciplined judgment. I draw from my latest obsession with epistemologies of ignorance to complicate their focus on disciplinarity with questions over how non-knowledge gets framed and created. I use Suniti Sharma's seven-year study to highlight the…

  20. Impacts of invasive alien plants on water quality, with particular emphasis on South Africa

    CSIR Research Space (South Africa)

    Chamier, J

    2012-04-01

    Full Text Available , 1997; f) Raid and Munshi, 1979; g) Polomski et al., 2009; h) Tripathi et al., 1991; i) Jadhav et al,. 2008; k) De Groot, 1993; l) Brendock et al., 2003; m) Sridhar and Sharma, 1985; n) Gratwicke and Marshall, 2001; o) De Wet et al., 1990; p) T...

  1. Marianne Mikko sai Gandhilt küllakutse

    Index Scriptorium Estoniae

    2007-01-01

    Euroopa Parlamendi liige Marianne Mikko osales India välisministeeriumi riigiministri Anand Sharma kutsel ainsa europarlamendi esindajana rahvusvahelisel konverentsil "Rahu, vägivallatus ja võim", kus esines kõnega "Haridus - eliidile või kõigile?" Allk.: M. V

  2. Career choice, influence

    African Journals Online (AJOL)

    Information Impact | Journal of Information and Knowledge Management

    Keywords: Career choice, influence, students, academic performance. Introduction ... Sharma (2012) also included that grade, attendance, standard test and .... outgoing. A student's personality must be a self-motivated type”. ..... Mercy Arodovwe Igere is a lecturer at the Department of Library and Information. Science.

  3. Analytic method for solitary solutions of some partial differential equations

    Energy Technology Data Exchange (ETDEWEB)

    Ugurlu, Yavuz [Firat University, Department of Mathematics, 23119 Elazig (Turkey); Kaya, Dogan [Firat University, Department of Mathematics, 23119 Elazig (Turkey)], E-mail: dkaya@firat.edu.tr

    2007-10-22

    In this Letter by considering an improved tanh function method, we found some exact solutions of the clannish random walker's parabolic equation, the modified Korteweg-de Vries (KdV) equation, and the Sharma-Tasso-Olver (STO) equation with its fission and fusion, the Jaulent-Miodek equation.

  4. Õnnitlused Vabariigi Presidendile ja eesti rahvale Eesti Vabariigi 75. aastapäeva puhul

    Index Scriptorium Estoniae

    1993-01-01

    Boriss Jeltsin, kuninganna Elisabeth, kuninganna Margrethe, kuningas Carl Gustaf, M. Koivisto, Th. Klestil (Austria Vabariigi Liidupresident), Yang Shangkun (Hiina Rahvavabariigi President), Shanker Daval Sharma, kuningas Baudouin, A. Ogi (Šveitsi Konföderatsiooni President), kuningas Harald, patriarh Aleksius. Ilmunud ka: Päevaleht 26. veebr. lk. 1

  5. Traveling with and through Your Backpack: A Personal Reflection on the Infrastructure of Science Education

    Science.gov (United States)

    Sammel, Alison

    2008-01-01

    In this paper I respond to Ajay Sharma's "Portrait of a Science Teacher as a Bricoleur: A case study from India," by speaking to two aspects of the bricoleur: the subject and the discursive in relation to pedagogic perspective. I highlight that our subjectivities are negotiated based on the desires of the similar and competing discourses…

  6. Study Habits and Academic Achievement of Kashmiri & Ladakhi Adolescent Girls: A Comparative Study

    Science.gov (United States)

    Nadeem, N. A.; Puja, Javeed Ahamd; Bhat, Shabir Ahmad

    2014-01-01

    The present study was conducted to study the Study Habits and Academic Achievement of Adolescents girls in Jammu and Kashmir. 400 sample subjects were selected randomly from two ethnic groups' viz. Kashmiri and Ladakhi. The investigators used Palsane & Sharma's study habits inventory (PSSHI) to collect data from the field. Certain statistical…

  7. Anti-tumor potential of total alkaloid extract of Prosopis juliflora DC ...

    African Journals Online (AJOL)

    Jane

    2011-08-15

    Aug 15, 2011 ... alkaloids on human cancer cell lines in vitro or in vivo has hitherto not ... excessive damage to normal cells (Sharma et al., 2009). With this ... origin which possess anti-tumor activities with a low ..... Coral reefs, forests, and.

  8. The Scope of the ZnO Growth

    Science.gov (United States)

    2001-01-01

    Characterization, and Applications of Single Crystals, Antoni Rogaski, Krzysztof Adamiec, Pawel Madejczyk, Editors, Proceedings of SPIE Vol. 4412 (2001...42. R.D. Vispute, V. Talansky, S. Choopun, R.P. Sharma, T. Venkatesan, M. He, X. Tang, J.B. Halpern, M.G. Spencer, Y.X. Li, L.G. Salamanca- Riba , A.A

  9. Eluviisi mõjust haigusele / Lilian Hankewitz

    Index Scriptorium Estoniae

    Hankewitz, Lilian

    2004-01-01

    Raamatu "Vähi vastu aitab see, kui me ei anna talle võimalust tekkidagi" autorid meditsiinidoktor Hari Sharma, ayurveda arst Rama Mishra ja dr. James Meade'i annavad nõu haigusvaenuliku pinnase loomises ja inimese organismi tugevdamises. Järgneb 19.,26. okt., 2., 9.,16.,23.,30. nov., 7.,14.,21. dets.

  10. Textile Calendar

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    Indian Commerce and Industry Minister Sharma said that India will not allow more cotton exports at present time on April 9, but the cotton recorded in the government and passed the verification again can be delivered. India as the world's second largest cotton exporter, its cotton export policy will continue to affect the global cotton trade and price trends.

  11. Development of somaclones in sugarcane genotype BF-162 and ...

    African Journals Online (AJOL)

    pris

    2012-02-21

    Feb 21, 2012 ... breeder assessment of genetic diversity, they are very essential in tissue ... Field growing somaclones in R0 generation were screened out for ... respect to culture media formulations, explant source ...... Hussnain Z, Afghan S (2006). ... Lal M, Singh RK, Srivastava S, Singh N, Singh SP, Sharma ML (2008).

  12. The Relationship of Academic Stress with Aggression, Depression and Academic Performance of College Students in Iran

    Science.gov (United States)

    Khanehkeshi, Ali; Basavarajappa

    2011-01-01

    This paper investigates the relationship of academic stress with aggression, depression and academic performance of college students. Using a random sampling technique, 60 students consist of boys and girls were selected as students having academic stress. The scale for assessing academic stress (Sinha, Sharma and Mahendra, 2001); the Buss-Perry…

  13. European Conference on Organized Thin Films (4th) Held in Bangor on September 10 - 12, 1992

    Science.gov (United States)

    1992-09-12

    2eposition ratios close to unity. (in agreement with recent results reported by Aveyard etal. 2) 1 A.Ulman,S.D.Evans,Y.Snidman,R.Sharma and J.E.Eilers...Chemistry, The University of Melbourne, Parkville, Victoria 3052, Australia CARUSO - P L MPI f~r biophysikalische Chemie, Am Fassberg, Postfach 2841, D

  14. Selenium Accumulation and Antioxidant Status of Rice Plants Grown on Seleniferous Soil from Northwestern India

    National Research Council Canada - National Science Library

    Sucheta SHARMA Reeti GOYAL Upkar Singh SADANA

    2014-01-01

    ... NortnWeStern lnala —J 。■一J’●■一■■●●●■■0 Sucheta SHARMA ,Reeti GOYAL ,Upkar Singh SADANA (1Department of Biochemistry,Punjab Agricultural University,Ludhiana 141 004,India...

  15. Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines for the management of patients with bipolar disorder : update 2013

    NARCIS (Netherlands)

    Yatham, Lakshmi N.; Kennedy, Sidney H.; Parikh, Sagar V.; Schaffer, Ayal; Beaulieu, Serge; Alda, Martin; O'Donovan, Claire; MacQueen, Glenda; McIntyre, Roger S.; Sharma, Verinder; Ravindran, Arun; Young, L. Trevor; Milev, Roumen; Bond, David J.; Frey, Benicio N.; Goldstein, Benjamin I.; Lafer, Beny; Birmaher, Boris; Ha, Kyooseob; Nolen, Willem A.; Berk, Michael

    Yatham LN, Kennedy SH, Parikh SV, Schaffer A, Beaulieu S, Alda M, ODonovan C, MacQueen G, McIntyre RS, Sharma V, Ravindran A, Young LT, Milev R, Bond DJ, Frey BN, Goldstein BI, Lafer B, Birmaher B, Ha K, Nolen WA, Berk M. Canadian Network for Mood and Anxiety Treatments (CANMAT) and International

  16. VITAL (Vanguard Investigations of Therapeutic Approaches to Lung Cancer)

    Science.gov (United States)

    2009-01-01

    E2 and thromboxane A2 (44). In addi- tion, Pold et al. (40) reported that cyclooxygenase-2 con- tributes to the progression of NSCLC tumorigenesis by...activity. J Immunol 2000;165:5269–77. 40. Pold M, Zhu LX, Sharma S, et al. Cyclooxygen- ase-2-dependent expression of angiogenic CXC chemokines ENA-78/CXC

  17. Development of an automated scoring system for plant comet assay

    Directory of Open Access Journals (Sweden)

    Bertrand Pourrut

    2015-05-01

    -\tnucleus density: increase the density of nuclei is of importance to increase scoring reliability (Sharma et al., 2012. In conclusion, increasing plant nucleus extraction yield and automated scoring of nuclei do represent big challenges. However, our promising preliminary results open up the perspective of an automated high-throughput scoring of plant nuclei.

  18. Rayleigh lidar investigation of sudden stratospheric warming observed over northern and southern hemisphere stations

    CSIR Research Space (South Africa)

    Sivakumar, V

    2006-07-01

    Full Text Available of sudden stratospheric warming observed over Northern and Southern hemisphere stations V. SIVAKUMAR1,2, H. Bencherif1, D.V.Acharyulu1, A. Hauchecorne3, D.N. Rao4, S. Sharma5 and P. B. Rao6 (1) Laboratoire de l’Atmosphère et des cyclones CNRS–UMR 8105...

  19. Marianne Mikko sai Gandhilt küllakutse

    Index Scriptorium Estoniae

    2007-01-01

    Euroopa Parlamendi liige Marianne Mikko osales India välisministeeriumi riigiministri Anand Sharma kutsel ainsa europarlamendi esindajana rahvusvahelisel konverentsil "Rahu, vägivallatus ja võim", kus esines kõnega "Haridus - eliidile või kõigile?" Allk.: M. V

  20. Childhood growth in boys with congenital hypogonadotropic hypogonadism

    DEFF Research Database (Denmark)

    Varimo, Tero; Hero, Matti; Laitinen, Eeva-Maria;

    2016-01-01

    and 9 from Denmark). Fifteen patients (42%) had representative growth measurements during the first year of life. Genetically verified diagnosis of CHH was made in 15 (42%) patients (KAL1, FGFR1, GNRHR, or PROK2). RESULTS: We found a deceleration of growth rate during early childhood. The mean (SD...

  1. The stoichiometry of synthetic alunite as a function of hydrothermal aging investigated by solid-state NMR spectroscopy, powder X-ray diffraction and infrared spectroscopy

    DEFF Research Database (Denmark)

    Grube, Elisabeth; Nielsen, Ulla Gro

    2015-01-01

    The stoichiometry of a series of synthetic alunite (nominally KAl3(SO4)2(OH)6) samples prepared by hydrothermal methods as a function of reaction time (1 – 31 days) has been investigated by powder X-ray diffraction, Fourier transform infrared spectroscopy as well as solid-state 1H and 27Al magic...

  2. ANKARA’DA ERKEN BİZANS DÖNEMİ MEZAR ALANI KAZISI / EARLY BYZANTINE CEMETERY EXCAVATION IN ANKARA

    National Research Council Canada - National Science Library

    Mahmut AYDIN; Candemir ZOROĞLU

    2016-01-01

    Roma Dönemi’nde Galatia Eyaleti’nin başkentliğini yapan Ankyra kentinin anıtsal yapıları ve diğer çarpıcı kalıntıları ile olası nekropol alanları genellikle Ankara’nın Erken Cumhuriyet...

  3. KA1(SO4)2·12H2O catalyzed efficient synthesis of 3,4,6-trisubstituted 2-pyridone in water

    Institute of Scientific and Technical Information of China (English)

    Majid M.Heravi; Hossein A. Oskooie; Narges Karimi; Hoda Hamidi

    2011-01-01

    An efficient green protocol for the preparation 3,4,6-trisubstituted 2-pyridone of employing a condensation reaction of cyanoacetamide and acetylacetone in the presence of KAl(SO4)2·12H2O in water has been described. The present procedure offers advantage such as shorter reaction time, simple workup, and excellent yields.

  4. Disease: H00255 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available ID:18987492 Hardelin JP, Dode C The complex genetics of Kallmann syndrome: KAL1, FGFR1, FGF8, PROKR2, PROK2,...opin deficiency. Pituitary 10:381-91 (2007) PMID:15722618 Karges B, de Roux N Molecular genetics

  5. The stoichiometry of synthetic alunite as a function of hydrothermal aging investigated by solid-state NMR spectroscopy, powder X-ray diffraction and infrared spectroscopy

    DEFF Research Database (Denmark)

    Grube, Elisabeth; Nielsen, Ulla Gro

    2015-01-01

    The stoichiometry of a series of synthetic alunite (nominally KAl3(SO4)2(OH)6) samples prepared by hydrothermal methods as a function of reaction time (1 – 31 days) has been investigated by powder X-ray diffraction, Fourier transform infrared spectroscopy as well as solid-state 1H and 27Al magic...

  6. KALIP ELEMANLARIN BİLGİSAYAR DESTEKLİ ÜÇ BOYUTLU TASARIMI

    Directory of Open Access Journals (Sweden)

    Kerim ÇETİNKAYA

    2000-02-01

    Full Text Available Saç metal kalıplarının klasik yöntemlerle tasarımı uzun süreli hesaplamalar ve çizimlerden oluşmaktadır. Kalıp tasarımında pekçok elemanın seçimi ve çizimi benzer işlemlerin tekrarı olduğundan zaman alıcıdır. Bu çalışmada, AutoCAD paket programına uyarlanmış olan AutoLISP kullanılarak bir kalıp tasarım programı hazırlanmıştır. Yapılan çalışma ile saç metal kalıplarının tasarımı ve boyutlandırılması gerçekleştirilmiştir.

  7. KECUKUPAN ENERGI DAN POLA KEGIATAN WANITA HAMIL

    Directory of Open Access Journals (Sweden)

    Y. Krisdinamurtirin

    2012-11-01

    Full Text Available Telah dihitung penggunaan energi berdasarkan kegiatan sehari-hari 33 orang wanita hamil triwulan kedua pengunjung Puskesmas Semplak, Bogor, Jawa Barat. Data kegiatan fisik responden dikumpulkan secara "recall" 2x24 jam oleh peneliti pada saat kunjungan rumah. Data antropometri, termasuk tebal lemak bawah kulit, serta data konsumsi makanan juga dikumpulkan. Umur kehamilan responden antara (6-24 minggu (±20,4, rata-rata berat badan 50,54 kg (±5,7 kg atau 4 kg lebih tinggi daripada rata-rata berat badan wanita tidak hamil tidak menyusui di kecamatan yang sama; tinggi badan 149,7 cm (±3,7cm dan tebal lemak badan 27,5% (±1,9% berat badan. Rata-rata masukan energi menurut hasil "recall" hanya 7652 (±527,4 kal, atau 79% dari kecukupan menurut Widya Karya Nasional Pangan dan Gizi 1983. Pengeluaran energi, dihitung berdasarkan kegiatan fisik, rata-rata 2609 Kal; berdasarkan BMR menurut cara FAO/WHO/UNU 1985, juga hampir sama 2611 Kal. Angka kecukupan energi wanita hamil triwulan kedua dengan berat badan 50 kg, menurut penelitian ini adalah 2600 Kal.

  8. Genetics of congenital hypogonadotropic hypogonadism in Denmark

    DEFF Research Database (Denmark)

    Tommiska, Johanna; Känsäkoski, Johanna; Christiansen, Peter

    2014-01-01

    of HH later in life. We examined the genetics and clinical features of CHH in Denmark. Forty-one male patients were screened for mutations in KAL1, FGFR1, FGF8, PROK2, PROKR2, GNRHR, TAC3, TACR3, and KISS1R. CHD7 was screened in two patients with hearing loss. In 12 patients, a molecular genetic cause...

  9. Newspaper Front Page Coverage of "the Korean Airliner Boeing 747 Massacre" in Six Newspapers.

    Science.gov (United States)

    Kang, Jong Geun

    A study investigated three United States and three foreign newspapers to determine the direction or bias of coverage of the 1983 Korean Airline (KAL) incident and any differences in coverage. It was hypothesized (1) that the amount of space allotted to the story in U. S. newspapers would be greater than that in foreign newspapers; (2) that there…

  10. Heavy metals and zooplankton with special reference to Minamata (Japan) mercury pollution - A case study

    Digital Repository Service at National Institute of Oceanography (India)

    Gajbhiye, S.N.; Hirota, R.

    Zooplankton samples were collected from nine stations in the three inland sea regions (Minamata Bay, Yatsushiro-Kai, and Ariake-Kal) along the western coast of Japan Between September 1980 to December 1986 and were analysed for total mercury. Some...

  11. Fundamental Research on a New Process to Remove Al3+ as Potassium Alum during Lithium Extraction from Lepidolite

    Science.gov (United States)

    Guo, Hui; Kuang, Ge; Yang, Jing-Xi; Hu, Song

    2016-12-01

    Sulfuric acid method can effectively extract lithium from lepidolite. However, purification problems make the method still tough before being widely applied. Especially, a considerable amount of Al3+ is contained in leaching solution, which needs to be removed before Li2CO3 precipitation. Based on the characteristic that K+, Rb+, and Cs+ can form corresponding alums with Al3+, an alum crystallization method was introduced and applied in our research. The feasibility of this method was also verified by phase equilibrium investigations in Li2SO4-K2SO4-Al2(SO4)3-H2O and its subternary system, which were typical subsystems of leaching solution. The results showed that Al2(SO4)3 can form potassium alum (KAl(SO4)2·12H2O) with K2SO4 easily, while no alum or double salt was found between Li2SO4 and Al2(SO4)3. Although Li2SO4 can generate KLiSO4 with K2SO4, the crystallization of KAl(SO4)2·12H2O still has priority over KLiSO4 when K2SO4 concentration is relatively low. Therefore, aluminum probably can be removed by regulating the concentration of leaching solution located in the crystallization field of KAl(SO4)2·12H2O. Besides, the effects of controlling factors specifically temperature, pH, and molar ratio of K+/Al3+ ( m (K+/Al3+)) on alum crystallization were investigated. The results indicated that lower temperature and the addition of K2SO4 can accelerate the removal of Al2(SO4)3 obviously. The alum crystallization method turned out to be effective such that about 78 pct of Al2(SO4)3 can be removed mainly as potassium alum (KAl(SO4)2·12H2O) at 278 K (5 °C) with m (K+/Al3+) at 0.9 and pH of 2. A slight loss of lithium was caused by entrainment during alum crystallization. This research can be a promising exploration to purify leaching solution of lepidolite or other aluminosilicates.

  12. Orbitofrontal cortex 5-HT2A receptor mediates chronic stress-induced depressive-like behaviors and alterations of spine density and Kalirin7.

    Science.gov (United States)

    Xu, Chang; Ma, Xin-Ming; Chen, Hui-Bin; Zhou, Meng-He; Qiao, Hui; An, Shu-Cheng

    2016-10-01

    Neuroimaging studies show that patients with major depression have reduced volume of the orbitofrontal cortex (OFC). Although the serotonin (5-HT) 2A receptor, which is abundant in the OFC, has been implicated in depression, the underlying mechanisms in the development of stress-induced depression remain unclear. Kalirin-7 (Kal7) is an essential component of mature excitatory synapses for maintaining dendritic spines density, size and synaptic functions. The aim of this study was to investigate the role of orbitofrontal 5-HT and 5-HT2A receptors in depressive-like behaviors and their associations with Kal7 and dendritic spines using chronic unpredictable mild stress (CUMS), an established animal model of depression. CUMS had no effect on the levels of 5-HT or the 5-HT2A receptor in the OFC. However, CUMS or microinjection of the 5-HT2A/2C receptor agonist (±)-1-(2, 5-Dimethoxy-4-iodophenyl)- 2-aminopropane hydrochloride (DOI, 5 μg/0.5 μL) into the OFC induced depressive-like behaviors, including anhedonia in the sucrose preference test and behavioral despair in the tail suspension test, a significant reduction in body weight gain and locomotor activity in the open field test, which were accompanied by decreased expression of Kal7 and PSD95 as well as decreased density of dendritic spines in the OFC. These alterations induced by CUMS were reversed by pretreatment with the 5-HT2A receptor antagonist Ketanserin (Ket, 5 μg/0.5 μL into the OFC). These results suggest that CUMS alters structural plasticity through activation of the orbital 5-HT2A receptor and is associated with decreased expression of Kal7, thereby resulting in depressive-like behaviors in rats, suggesting an important role of Kal7 in the OFC in depression.

  13. Photocatalytic degradation of acetaminophen in modified TiO2 under visible irradiation.

    Science.gov (United States)

    Dalida, Maria Lourdes P; Amer, Kristine Marfe S; Su, Chia-Chi; Lu, Ming-Chun

    2014-01-01

    This study investigated the photocatalytic degradation of acetaminophen (ACT) in synthetic titanium dioxide (TiO2) solution under a visible light (λ >440 nm). The TiO2 photocatalyst used in this study was synthesized via sol-gel method and doped with potassium aluminum sulfate (KAl(SO4)2) and sodium aluminate (NaAlO2). The influence of some parameters on the degradation of acetaminophen was examined, such as initial pH, photocatalyst dosage, and initial ACT concentration. The optimal operational conditions were also determined. Results showed that synthetic TiO2 catalysts presented mainly as anatase phase and no rutile phase was observed. The results of photocatalytic degradation showed that LED alone degraded negligible amount of ACT but with the presence of TiO2/KAl(SO4)2, 95% removal of 0.10-mM acetaminophen in 540-min irradiation time was achieved. The synthetic TiO2/KAl(SO4)2 presented better photocatalytic degradation of acetaminophen than commercially available Degussa P-25. The weak crystallinity of synthesized TiO2/NaAlO2 photocatalyst showed low photocatalytic degradation than TiO2/KAl(SO4)2. The optimal operational conditions were obtained in pH 6.9 with a dose of 1.0 g/L TiO2/KAl(SO4)2 at 30 °C. Kinetic study illustrated that photocatalytic degradation of acetaminophen fits well in the pseudo-first order model. Competitive reactions from intermediates affected the degradation rate of ACT, and were more obvious as the initial ACT concentration increased.

  14. Fungi Encountered on Footwear and Defence Articles

    Directory of Open Access Journals (Sweden)

    O. P. Sharma

    1980-10-01

    Full Text Available A study of mycoflora on footwears and defence articles from Agra city was made. In all 38 fungi belonging to different genera were recorded. Out of these, 17 fungal species were isolated for the first on these articles. A new variety i.e., Aspergillus sydowii var. agraii Sharma and Sharma was also created. Species of Aspergillus, Penicillium, Paecilomyces, Drechslera, Alternaria, Fusarium and Trichoderma were found to be dominant in all the cases. Maximum species were recorded from gents footwear and books ankle in comparison to ladies footwear. All these fungi were grouped as (i active (15 isolates, (iimoderate (15 isolates and (iii slow leather deteriogens (8 isolates on the basis of screening.

  15. A Novel Ranking Algorithm of Query Words Stored in QIIIEP Server

    Directory of Open Access Journals (Sweden)

    Dilip Kumar Sharma

    2010-11-01

    Full Text Available This paper proposes a novel algorithm for the ranking of query words stored in QIIIEP server which are used for posting the query to extract the contents from deep web (Sharma and Sharma, 2009. These words can be collected from either by auto query words extraction module or submitted by web master of third party sites. This paperanalyze different existing algorithms for ranking of query words and suggest an improved algorithm for the same by including newer parameters for ranking of query words. An elaborate analysis is carried on the concept of query words ranking so as to come up with an improved algorithm with enhanced efficiency and one in conformance with the global standards. Proposed algorithm analyzes the context of web page with respect to the supplied keywords and frequency of simultaneous occurrence for same keyword on surface web to assign a numerical weighting to each query word with the purpose of "measuring" its relative importance within the set.

  16. A New Anisotropic Compact Star Model having Matese \\& Whitman Mass Function

    CERN Document Server

    Bhar, Piyali

    2015-01-01

    A new singularity free model of anisotroipic compact star is proposed. The Einstein field equations are solved in closed form by utilizing Matese \\& Whitman mass function. The model parameters $\\rho$, $p_r$ and $p_t$ all are well behaved inside the stellar interior and our model satisfies all the required conditions to be physically acceptable. The model given in the present work is compatible with observational data of compact objects like SAX J 1808.4-3658 (SS1), SAX J 1808.4-3658 (SS2) and 4U 1820-30. A particular model of 4U 1820-30 is studied in detail and found that it satisfies all the condition needed for physically acceptable model. The present work is the generalization of Sharma and Ratanpal\\cite{sharma13} model for compact stars admitting quadratic equation of state.

  17. A systematic updated review of scientifically tested selected plants used for anxiety disorders

    OpenAIRE

    Sharma A; Cardoso-Taketa A; García G; Villarreal ML

    2012-01-01

    Ashutosh Sharma, Alexandre Cardoso-Taketa, Griselda García, María Luisa VillarrealCentro de Investigación en Biotecnología, Universidad Autónoma del Estado de Morelos, Cuernavaca, MexicoAbstract: The aim of this review is to provide a summary on multidisciplinary scientific information obtained from medicinal plants used worldwide to treat anxiety, focusing on pharmacological and clinical studies. The bibliographical investigation was car...

  18. A Study on Ethnocentric Tendencies of Ethopian Consumers

    OpenAIRE

    V.S. Mangnale; Rajasekhara Mouly Potluri; Habtamu Degufu

    2011-01-01

    The purpose of this research is to deduce and analyze the ethnocentric inclinations of the Ethiopian consumers for products and services by determining the applicability of Consumer Ethnocentric Tendencies Scale (CETSCALE). This study thoroughly reviews the existing literature on ethnocentrisms. The CETSCALE (Consumer Ethnocentric Tendencies Scale) developed by Shimp and Sharma was adopted to measure the magnitude of ethnocentrism in both the product and service markets. 500 questionnaires we...

  19. Using standard CETSCALE and other adapted versions of the scale for measuring consumers’ ethnocentric tendencies: An analysis of dimensionality

    OpenAIRE

    José Felipe Jiménez-Guerrero; Juan Carlos Gázquez-Abad; Emilia del Carmen Linares-Agüera

    2014-01-01

    The consumer ethnocentrism tendencies scale (CETSCALE) was developed by Shimp and Sharma in 1987 to measure consumer ethnocentrism. It is one of the most commonly used scales in the marketing literature. As well as the original 17-item version, there are many empirical applications using other adapted versions of CETSCALE. These versions differ in terms of the number (and composition) of items, incorporating additional items and even accounting for the nationality of the foreign products unde...

  20. Enhancing graphene/CNT based electrochemical detection using magneto-nanobioprobes

    OpenAIRE

    sprotocols

    2015-01-01

    Authors: Priyanka Sharma, V Bhalla, E Senthil Prasad, V Dravid, G Shekhawat & C. Raman Suri ### Abstract This protocol describes an optimized signal amplification strategy to develop an ultra-sensitive magneto-electrochemical biosensing platform. The new protocol combines the advantages of carbon nanotube (CNT) and reduced graphene oxide (rGO) together with electrochemical bursting of magnetic nanoparticles. The method involves synthesis of gold-iron (Au/Fe) nano-structures func...

  1. An Interactive Bayesian Geostatistical Inverse Protocol for Hydraulic Tomography

    Science.gov (United States)

    2008-07-25

    Boise State University, Boise, Idaho, USA. 3Civil and Environmental Engineering , Stanford University, Stanford, California, USA. Copyright 2008 by...probabilistic approach acknowledges the nonuniqueness of the parameter estimation problem and incorporates uncertainty from multiple sources into the...compression and image focusing, Geophysics, 67(5), 1532–1541, doi:10.1190/1.1512749. Sharma, P. V. (1997), Environmental and Engineering Geophysics, Cam

  2. Core Logistics Capability Policy Applied to USAF Combat Aircraft Avionics Software: A Systems Engineering Analysis

    Science.gov (United States)

    2010-06-01

    cannot make a distinction between software maintenance and development” (Sharma, 2004). ISO/ IEC 12207 Software Lifecycle Processes offers a guide to...synopsis of ISO/ IEC 12207, Raghu Singh of the Federal Aviation Administration states “Whenever a software product needs modifications, the development...Sustainment for the F-35 Lightning II. (C. Johnstun, Ed.) Crosstalk: The Journal of Defense Software Engineering , 20 (12), 9-14. 130

  3. Acoustic properties of Indian Ocean manganese nodules in relation to physical constitution and chemical composition

    Digital Repository Service at National Institute of Oceanography (India)

    Mukhopadhyay, R.; Ramana, Y.V.

    , 1984; MA et al., 1986). This paper attempts to study the acoustical properties of nodules from different sediment environments in the Indian Ocean, because the physical constitution of nodules provides information on it's crystallochemical structure..., respectively. The above measurements were carried out following pulse transmit time method (SUBBARAJU and RAMANA, 1986) and verified by the compen- sated ultrasonic timer technique (RAMAt~A and SHARMA, 1984). Physical and acoustic properties were determined...

  4. A procedure to construct exact solutions of nonlinear fractional differential equations.

    Science.gov (United States)

    Güner, Özkan; Cevikel, Adem C

    2014-01-01

    We use the fractional transformation to convert the nonlinear partial fractional differential equations with the nonlinear ordinary differential equations. The Exp-function method is extended to solve fractional partial differential equations in the sense of the modified Riemann-Liouville derivative. We apply the Exp-function method to the time fractional Sharma-Tasso-Olver equation, the space fractional Burgers equation, and the time fractional fmKdV equation. As a result, we obtain some new exact solutions.

  5. Exp-function method for solving fractional partial differential equations.

    Science.gov (United States)

    Zheng, Bin

    2013-01-01

    We extend the Exp-function method to fractional partial differential equations in the sense of modified Riemann-Liouville derivative based on nonlinear fractional complex transformation. For illustrating the validity of this method, we apply it to the space-time fractional Fokas equation and the nonlinear fractional Sharma-Tasso-Olver (STO) equation. As a result, some new exact solutions for them are successfully established.

  6. Environmental issues of deep-sea mining

    Digital Repository Service at National Institute of Oceanography (India)

    Sharma, R.

    responsibility of organizing committee of the Global Challenges, Policy Framework & Sustainable Development for Mining of Mineral and Fossil Energy Resources. doi: 10.1016/j.proeps.2015.06.026 Available online at www.sciencedirect.com ScienceDirect *OREDO...-review under responsibility of organizing committee of the Global Challenges, Policy Framework & Sustainable Development for Mining of Mineral and Fossil Energy Resources. 205 Rahul Sharma / Procedia Earth and Planetary Science 11 ( 2015 ) 204 – 211 ZDYHV...

  7. The H-Function and Probability Density Functions of Certain Algebraic Combinations of Independent Random Variables with H-Function Probability Distribution

    Science.gov (United States)

    1981-05-01

    involving modified Bessel function and Fox’s H- function," Rivista di Matematica della Universita di Parma. Italie, (3) 2, 109-113 (1973). function...Ciencias Matematicas , A(2) 14, 105-111 (1971-72). 100. Dahiya, R. S., "ultiple integrals and the transformations involving H- functions and Tchebichef...transform," R di Matematica della Universita di Parma. Italie, 5, 159- 164 (1964). 117. Gupta, R. K., and S. D. Sharma, "Some infinite integrals involv- ing

  8. Review of the theoretical and empirical literature of consumer ethnocentrism

    OpenAIRE

    Stamule Stere; Bora Trajani

    2015-01-01

    This article presents an analysis of the concept of consumer ethnocentrism measured by the researchers with the use of the Consumer Ethnocentric Tendencies Scale (CETSCALE) developed by Shimp and Sharma in 1987. The communication campaigns promoting the consumption of goods produced in Romania were revised together with the European legislation regarding this type of campaigns. While country-of-origin and ethnocentrism have been extensively researched, the link between CE and the attitude tow...

  9. Quadrature formulas for Fourier coefficients

    KAUST Repository

    Bojanov, Borislav

    2009-09-01

    We consider quadrature formulas of high degree of precision for the computation of the Fourier coefficients in expansions of functions with respect to a system of orthogonal polynomials. In particular, we show the uniqueness of a multiple node formula for the Fourier-Tchebycheff coefficients given by Micchelli and Sharma and construct new Gaussian formulas for the Fourier coefficients of a function, based on the values of the function and its derivatives. © 2009 Elsevier B.V. All rights reserved.

  10. The Second Moments for the Meyer-Konig and Zeller Operators on the Simplex

    Institute of Scientific and Technical Information of China (English)

    张春苟

    2002-01-01

    @@ The moments for positive linear operators, in particular the second order's, is an interest topic in theory of approximation. In 1984, Alkemade[1] succeed in deriving an explicit expression of the second moment in terms of a hypergeomctric series for the Meyer-Konig and Zeller operators. Later in 1995, Abel[2] extend it to arbitrary order. The Meyer-Konig and Zeller operators in slight modification of Cheney and Sharma[a] are defined as follows

  11. Terrain Classification and Identification of Tree Stems Using Ground-Based Lidar

    Science.gov (United States)

    2012-12-01

    enhance UGV localization (Vandapel et al., 2006; Carle et al., 2010). In the forestry domain, tree stem modeling can be used for estimating biomass ...Surface lidar remote sensing of basal area and biomass in deciduous forests of eastern Maryland, USA. Remote Sensing of Environment, 67, 83-98...Microsoft Research. Sharma, M., Parton, J. (2009). Modeling Stand Density Effects on Taper for Jack Pine and Black Spruce Plantations Using

  12. Novel Nomogram That Predicts Aggressive Disease and Treatment Failure Among African-American Men with Prostate Cancer

    Science.gov (United States)

    2015-12-01

    association study to identify single nucleo - tide polymorphisms (SNPs) associated with the development of erectile dysfunction in African- American men...prostate needle biopsy beyond that provided by basal cell markers? Am J Surg Pathol 28:239-243, 2004 34. Sharma A, Yeow WS, Ertel A, et al: The... basal cell marker and is required for prostate development. Am J Pathol 157:1769-1775, 2000 44. Fisher G, Yang ZH, Kudahetti S, et al: Prog- nostic

  13. CASES ON GLOBAL E-LEARNING PRACTICES:Successes and Pitfalls

    OpenAIRE

    Yavuz Akbulut

    2007-01-01

    “Cases on Global E-Learning Practices: Successes and Pitfalls” look into the global practices of e-learning which has assumed a considerable role in the education sector recently. It is edited by Ramesh C. Sharma and Sanjaya Mishra from Indira Gandhi National Open University in New Delhi, India. It is published by Information Science Publishing, which is an imprint of Idea Group, an international publishing company specializing in research publications in the fields of technology, management ...

  14. Reflection of animosities among countries on consumers: A conceptual study on consumer animosity conceptÜlkeler arasındaki düşmanlıkların tüketicilere yansıması: Tüketici düşmanlığı kavramı üzerine kavramsal bir çalışma

    OpenAIRE

    Kiracı, Hakan

    2017-01-01

    Consumer animosity which was firstly defined by Klein et al. (1998) is often used to explain consumers’ buying behavior from a foreign country. Considering the findings and results of past empirical studies, it could be seen that consumer animosity especially was a stronger predictor of willingness to buy foreign (target country-ies) products and consumer animosity was significantly distinct structure from consumer ethnocentrism which was previously conceptualized by Shimp and Sharma (1987). ...

  15. Acute pneumonitis secondary to subcutaneous silicone injection

    Directory of Open Access Journals (Sweden)

    Gopie P

    2011-06-01

    Full Text Available Priya Gopie, Sateesh Sakhamuri, Anu Sharma, Sanjeev Solomon, Surujpal TeelucksinghClinical Medical Sciences, University of the West Indies, St Augustine, TrinidadAbstract: Following silicone injection, end organ toxicity can occur. To our knowledge this report documents the first case of silicone embolization in the Caribbean and serves to highlight an emergent danger associated with its illicit use for cosmetic purposes in this region.Keywords: silicone, silicone embolism, silicone pneumonitis, alveolar hemorrhage, pneumonitis

  16. Novel and emerging approaches to combat adolescent obesity

    OpenAIRE

    Manoj Sharma; Paul Branscum

    2010-01-01

    Manoj Sharma, Paul BranscumHealth Promotion and Education and Public Health Sciences, University of Cincinnati, Cincinnati, OH, USAAbstract: Overweight and obesity continue to be health concerns facing today’s adolescent population. Along with metabolic and physical problems associated with obesity, today’s obese adolescents also face many psychological issues such as high rates of depression, anxiety, and social discrimination. Obesity is commonly recognized as having man...

  17. Enhancing graphene/CNT based electrochemical detection using magneto-nanobioprobes

    OpenAIRE

    sprotocols

    2015-01-01

    Authors: Priyanka Sharma, V Bhalla, E Senthil Prasad, V Dravid, G Shekhawat & C. Raman Suri ### Abstract This protocol describes an optimized signal amplification strategy to develop an ultra-sensitive magneto-electrochemical biosensing platform. The new protocol combines the advantages of carbon nanotube (CNT) and reduced graphene oxide (rGO) together with electrochemical bursting of magnetic nanoparticles. The method involves synthesis of gold-iron (Au/Fe) nano-structures func...

  18. [A new Habronematidae parasite of Acryllium vulturinum: Sicarius renatae sp.n].

    Science.gov (United States)

    Cancrini, G; Balbo, T; Iori, A

    1991-12-01

    A new Nematode Habronematidae, Sicarius renatae sp.n., is described in Acryllium vulturinum from Somalia. This new species can be distinguished from S. dipterum (Popova, 1927), S. hoopoe Sharma, 1971 and S. caudatus Quentin and Wertheim, 1975 by its smaller body dimensions, the size of the spicula, the distribution and number of male caudal papillae, and by the morphology of the female posterior end.

  19. Computational Studies of Energetic Organic Molecules

    Science.gov (United States)

    1993-12-27

    1986]. They are hypothetical chemical processes in which the number of bonds of each formal type remains the same on each side of the equation , but...Politzer, Abrahmsen, Sjoberg, and Laurence, 1983; Politzer, Bar- Adon and Miller, 1987; Politzer, Jayasuriya and Zilles , 1985; Politzer...Isothermal Differential Scanning Calorimetry Analysis." J. Org. Chem. 42, 4201. 38 Sharma, J., Hoffsomer, J. C., Glover, D. J., Coffey, C. S., Santiago, F

  20. Hand in Hand, to Achieve Win-Win

    Institute of Scientific and Technical Information of China (English)

    Yang Wei

    2007-01-01

    @@ Mr.Thomas J.Donohue.President and CEO of the U.S.Chamber of Commerce,Mr.Yasuo Hayashi,Chairman and CEO of the Japan External Trade Organization, and Mr.Madhav Sharma,Chief Representative of the Confederation of Indian Industries Shanghai Representative Office,will have a busy late October as all of these senior officers will take part in the 2007 China (Wuxi) International Cooperation Forum for Commercial Associations & International Business Exchange Conference.

  1. Le "peuple cernois"

    CERN Multimedia

    Kiviuk; CERN

    2007-01-01

    Sur une idée de Philippe Bohn avec la collaboration du CERN. Clip présenté lors de la cérémonie officielle de l'inauguration du LHC Avec Maria Fidecaro (physicienne italienne), Marcos Marino Beiras (mathematicien espagnol), Francois Grey (informaticien canadien), Maarit White (ingénieure finlandaise), Michel Caccioppoli (technicien construction italien), Archana Sharma (physicienne indienne)

  2. Environmental studies for deep seabed mining

    Digital Repository Service at National Institute of Oceanography (India)

    Sharma, R.

    and re- colonization of deep-sea environment and animal communities. A comparison of the sediment resuspended during these experiments, shows that these were much smaller in scale than a commercial mining system (Yamazaki and Sharma). Potential... of mining system and the difference in the scale of test mining as well as of the experiments conducted, many questions remain unanswered, which need to be considered in future. Introduction Deepsea mining has been a subject of interest around...

  3. Fully Coupled Thermomechanical Finite Element Analysis of Material Evolution During Friction-Stir Welding of AA5083

    Science.gov (United States)

    2009-09-03

    Sharma, S. R., and Mishra, R. S. Effect of friction stir processing on the microstructure of cast A356 aluminum . Mater. Sci. Engng A, 2006, 433, 269...J. and Thomas, W. M. Friction stir process welds aluminum alloys. Welding J., 1996, 75, 41–52. 3 Thomas, W. M. and Dolby, R. E. Friction stir welding...273. 8 Su, J. Q., Nelson, T. W., Mishra, R., and Mahoney, M. Microstructural investigation of friction stir welded 7050-T651 aluminum . Acta Mater., 2003

  4. Stability of binaries. Part II: Rubble-pile binaries

    Science.gov (United States)

    Sharma, Ishan

    2016-10-01

    We consider the stability of the binary asteroids whose members are granular aggregates held together by self-gravity alone. A binary is said to be stable whenever both its members are orbitally and structurally stable to both orbital and structural perturbations. To this end, we extend the stability analysis of Sharma (Sharma [2015] Icarus, 258, 438-453), that is applicable to binaries with rigid members, to the case of binary systems with rubble members. We employ volume averaging (Sharma et al. [2009] Icarus, 200, 304-322), which was inspired by past work on elastic/fluid, rotating and gravitating ellipsoids. This technique has shown promise when applied to rubble-pile ellipsoids, but requires further work to settle some of its underlying assumptions. The stability test is finally applied to some suspected binary systems, viz., 216 Kleopatra, 624 Hektor and 90 Antiope. We also see that equilibrated binaries that are close to mobilizing their maximum friction can sustain only a narrow range of shapes and, generally, congruent shapes are preferred.

  5. Guidance, Navigation and Control. Digital Emulation Technology Laboratory. Volume 3. Part 2. Task 3. Special Studies

    Science.gov (United States)

    1991-09-27

    kal, ka2, ka3, ka4, ka5IREAL kv, kvl, kv2, kv3 , kv4, kv5 REAL pm(3), psier, thter, attlm DATA kal/.0015/, ka2/.0015/, ka3/.0013/, ka4I.0ll/, ka5/.0045...DATA kvlI.00013/, kv2I.000131, kv3 /O.O/, kv4IO.0/, kv5/0.O/IDATA tc/0.751, ts/14.5/, t5/46.0/, t2s/58.21, tcd & /60.2/ DATA iminsf/0/, vwlim/10.0...THEN ka = ka3Ikv = kv3 ELSEIF (t .LE. t2s) THEN ka = ka4 kv = kv4I ELSE ka = ka5 kv = kv5 ENDI FI c launch steering mode IF (t .LE. tc) THEN CALL

  6. TÜRK İNŞAAT SEKTÖRÜNDEKİ TÜNEL KALIP TEKNOLOJİSİ   UYGULAMALARINDA PREKAST YAPI BİLEŞENLERİ PROJELENDİRME VE   UYGULAMA SORUNLARININ NEDEN VE ÇÖZÜMLERİ

    OpenAIRE

    KORUR, Saim; OĞUZALP, Ercan H.; SIRAMKAYA, Süheyla Büyükşahin

    2006-01-01

    Bu çalışmanın kapsamı içinde ele alınan araştırmanın konusu, tünel kalıp sistemle üretilen konutlarda kullanılan prekast yapı bileşenlerinin taşıyıcı sisteme entegrasyonu ve birleşim yeri sorunlarının belirlenmesidir. Bu amaç doğrultusunda, tünel kalıp sistemin üretim hızını olumlu yönde etkileyen prefabrike yapı bileşenleri tanıtılarak, özellikle prekast cephe panelleri ve merdivenlerde projelendirme ve uygulama hatalarından dolayı karşılaşılan problemler yerinde yapılan t...

  7. A Novel Inorganic Low Melting Electrolyte for Secondary-Aluminum-Nickel Sulfide Batteries

    DEFF Research Database (Denmark)

    Hjuler, H.A.; Winbrush, S. von; Berg, Rolf W.;

    1989-01-01

    A new, inorganic low melting electrolyte with the composition LiAlCl4-NaAlCl4-NaAlBr4-KAlCl4 (3:2:3:2) [or equivalentlyLiAlBr4-NaAlCl4-KAlCl4 (3:5:2)] has been developed. The melting point for this neutral melt is 86°C; the decompositionpotential is approximately 2.0V; the ionic conductivity...... ±10% from their combination expectations. The low melting electrolyte is employed in the rechargeable batterysystem Al/electrolyte/Ni3S2 at 100°C. The open-circuit voltage of this system is from 0.82 to 1.0V. Dendrite-free aluminumdeposits are obtained. The cycling behavior of the battery system...

  8. Investigation of the mineral components of porcelain raw material and their phase evolution during a firing process by using a Rietveld quantitative analysis

    Science.gov (United States)

    Kim, Jaegyeom; Heo, Eunae; Kim, Seung-Joo; Kim, Jong-Young

    2016-01-01

    A ceramic raw material for white porcelain and its phase evolution during a firing process were investigated by using Rietveld method based on powder X-ray diffraction data. The raw material was mainly composed of five mineral phases: quartz (SiO2), microcline (KAlSi3O8), albite (NaAlSi3O8), muscovite (KAl2(AlSi3O10)(OH)2), and kaolinite (Al2Si2O5(OH)4). The amount of each mineral phase could be determined by using Rietveld quantitative phase analyses. During the firing process, the microcline, albite, muscovite and kaolinite phases started to react with each other to produce the mullite phase embedded in an amorphous matrix. The amount of quartz remained nearly unchanged until a temperature above 1200 °C; then, it converted to an amorphous phase at higher temperatures.

  9. Microstructure Assessment of Metakaolin Based-Geopolymers Produced with Alternative Silica Sources Exposed to High Temperatures

    Directory of Open Access Journals (Sweden)

    Villaquirán-Caicedo Mónica Alejandra

    2015-01-01

    Full Text Available Ceramic materials more environment friendly and with similar or even better performance than traditional ones can be produced by alkali activation of natural minerals, wastes or industrial by-products. The present study assesses the effect of exposure at 600° and 1200°C of a MK-based geopolymers. Rice husk ash (RHA and silica fume were modified chemically in order to obtain an alternative alkali activator. Exposure to elevated temperatures leads to dehydration of the reaction products and structural reorganization associated with the crystallization of the gel to leucite (KAlSi2O6 and kalsilite (KAlSiO4. The structural changes associated with the thermal treatment also promote a densification and reduction of porosity. The unreacted MK particles embedded into the geopolymeric gel lead to the formation of mullite (2Al2O3 × SiO2 after the thermal treatment at 1200°C.

  10. Implant marketing: cost effective implant dentistry.

    Science.gov (United States)

    Wohrle, P S; Levin, R P

    1996-01-01

    The application of the KAL-Technique to the field of implant dentistry allows both patients and dental practices to benefit. It is an exciting advance that decreases frustration and stress in providing implant procedures and lowers overall costs. Professionals using the KAL-Technique report significant predictability in achieving passive framework fit. They are also lowering overall cost of implant cases, which increases the number of patients who can accept implant treatment. It has been well established that the more individuals in a practice that receive implants, the more referrals a practice will gain. This is because implant patients find tremendous advances in the quality of life, and do not hesitate to tell others who can take advantage of this opportunity. Implant dentistry is one of the fastest growing fields in dentistry today. While some other areas of dentistry begin to decline in volume and need, implant dentistry provides the opportunity to keep practices strong and to insure long-term success.

  11. CTC Sentinel. Volume 8, Issue 6, June 2015

    Science.gov (United States)

    2015-06-01

    intensified during Algeria’s bitter civil war during the 1990s. As Algerian leaders sought to consolidate their rule after crushing the decade-long...start of the first Russo-Chechen war that began Contents FEATURE ARTICLE 1 The Islamic State Raises Its Black Flag Over The Caucasus By Derek...Approaches in Algerian Security Cooperation By Kal Ben Khalid 21 Haunted by their Past: Kurds and the Islamic State By Hoshang Waziri and Lydia

  12. Refinement of the localization of the X-linked ocular albinism gene

    Energy Technology Data Exchange (ETDEWEB)

    Bergen, A.A.B.; Zijp, P.; Schuurman, E.J.M.; Bleeker-Wagemakers, E.M.; Apkarian, P. (Netherlands Ophthalmic Research Inst., Amsterdam (Netherlands)); Ommen, G.J.B. van (Univ. of Leiden (Netherlands))

    1993-04-01

    Although physical and genetic mapping studies assigned the X-linked ocular albinism gene to Xp22.3, the exact gene order in this region is still unclear. The authors present additional genetic mapping data concerning X-linked ocular albinism that suggests the consensus order Xpter-STS-DXS237-KAL-(OA1, DXS143)- DXS85-DXS16-Xcen. 14 refs., 1 fig.

  13. EVALUACION DEL COMPORTAMIENTO BIOLOGICO, CLINICO Y MICROBIOLOGICO DE RESINAS DE ULTIMA GENERACION

    OpenAIRE

    Velermoro, Victor; Profesores de la Facultad de Odontología. UNMSM.; Moromi, Hilda; Profesores de la Facultad de Odontología. UNMSM.; Gálvez, Luis; Profesores de la Facultad de Odontología. UNMSM.; Salcedo, Doris; Profesores de la Facultad de Odontología. UNMSM.; Paz F., Juan José; Profesores de la Facultad de Odontología. UNMSM.; Quintana, Carmen; Profesores de la Facultad de Odontología. UNMSM.; Ayala, Gerardo; Profesores de la Facultad de Odontología. UNMSM.

    2014-01-01

    An study of three clases of resins of last generation was done evaluating the clinical conduct histological, microbiological and microfiltración through electronical microscopic concluting that the clinical answer in the three tippies of resins in casties of 3 mm of intensity were not present, in histologic grade you cannot see qualitive changes, in the microbiological aspect it was verified y kal the efect antimi crobianie is only produced with direct contact with the resens through the shap...

  14. Variable stoichiometry in tectosilicates having the leucite/pollucite-type structure with particular emphasis on modelling the interframework cavity cation environment

    Science.gov (United States)

    Henderson, C. M. B.; Bell, A. M. T.; Knight, K. S.

    2017-07-01

    Unit cell data for synthetic samples of I41/a or Ia-3d AAlSi2O6 (A=K,Rb,Tl,Cs) leucite/pollucites are compared to those for feldspar-stoichiometry leucite analogues (Rb,Tl,Cs)0.75□0.25Al0.75Si2.25O6. I41/a solid solutions between KAlSi2O6 and KAlSi3O8 (orthoclase feldspar, Or) and between K(Al0.85Fe0.15)Si2O6 and Or both show increasing volumes and decreasing c/a with increasing Or. Phase relations are given for KAlSi3O8-RbAlSi3O8; monoclinic feldspars occur at low temperatures and I41/a leucites at higher temperatures; volumes of leucite solid solutions increase with increasing Rb. The cell volume of Rb0.75□0.25Al0.75Si2.25O6 leucite is larger than that of RbAlSi2O6 leucite. Published leucite/pollucite structures belonging to different Space Group symmetries are treated as having the cubic Ia-3d topology with a 'pseudocell' edge V1/3 (V = unit cell volume); inequivalent site bond lengths and angles provide mean structural parameters for the cubic 'pseudocells'. Multivariant linear regression equations using mean A - O distances as the independent variable were obtained using other structural parameters as dependent variables. Only two independent variables (V and mean tetrahedral ionic radius) are required to account for >90% of the variation. These regression equations can be used to predict the sizes of the cavity cation sites in leucite/pollucite-type phases of any stoichiometry.

  15. Interactions and Spreading of Adjacent Large Area Fires

    Science.gov (United States)

    1986-03-31

    1985] and a city such as Hamburg for which the load was estimated at 157 kg/m 2 [Carrier, Fendell , and Feldman, 1985]. The caloric equivalent of those...Protec- tion Association, Boston, Massachusetts, 1951. Carrier, G. F., F. E. Fendell , and P. S. Feldman, "Firestorms," J. Heat Trans., Vol. 107, 1985...ATTN: C SCAWTHORN TRW ELECTRONICS & DEFENSE SECTOR ATTN: F FENDELL FACTORY MUTUAL RESEARCH CORP ATTN: R FRIEDMAN 37 KAL""h -XZ1 38 1 I

  16. The Israeli Approach to Irregular Warfare and Implications for the United States

    Science.gov (United States)

    2007-02-01

    tabula - rasa strategy later resulted in recriminations and reevaluation. In Tall Afar and Ramadi, U.S. forces implemented tactics to secure and gain...Sayeret Golani, and possi- bly Sayeret Mat’Kal.17 Israeli special units played a large role in a highly successful counterinsurgency campaign along...transmissions. The Aman plays a predominate role in setting missions of small special forces. A tendency within the Israeli SOF community that has been less

  17. Corrigendum to ;The redox budget of crust-derived fluid phases at the slab-mantle interface; [Geochim. Cosmochim. Acta 209 (2017) 70-84

    Science.gov (United States)

    Malaspina, N.; Langenhorst, F.; Tumiati, S.; Campione, M.; Frezzotti, M. L.; Poli, S.

    2017-09-01

    On page 76, line 13 of Section 4.1.2. and caption of Figure 6, the sentence ;chemographic representation for the system Fe3O4-CaMgO2-KAlSiO4 at fixed SiO2 chemical potential, projected through the FeMg-1 exchange vector; must be completed adding; and projected from CaMgO2

  18. 7039 ALÜMİNYUM ALAŞIMININ KAYNAK ÖNCESİ VE SONRASI MEKANİK VE BALİSTİK ÖZELLİKLERİNİN ARAŞTIRILMASI

    OpenAIRE

    2013-01-01

    Bu çalışmada, kalınlıkları farklı (12,7 ve 38 mm) 7039 Al-Zn zırh levhalarına özel kaynak ağzı açılarak MIG kaynak yöntemiyle çoklu paso kaynak yapıldı. Bu kaynaklı levhaların balistik ve mekanik özellikleri araştırıldı. 38 mm kalınlığındaki kaynaklı levhanın ana metal, geçiş bölgesi ve kaynak metali kısımlarına 12,7 mm’lik zırh delici mermilerle atış yapılarak bu bölgelerin V50 balistik sınır değerleri tespit edildi. Mekanik özelliklerin belirlenmesinde ise 12.7 mm kalınlığındaki kaynaklı le...

  19. KENARLARI MASİFLİ VE MASİFSİZ MDF LEVHALARINDA KAVELA ÇAPLARININ ÇEKME DİRENCİNE ETKİLERİ

    Directory of Open Access Journals (Sweden)

    Yalçın ÖRS

    1999-03-01

    Full Text Available Bu çalışmada, kenarları 5, 8 ve 12 mm kalınlığında kayın masif malzeme ile masiflenmiş ve masiflenmemiş orta yoğunlukta lif levha (MDF deney örneklerine 6, 8 ve 10 mm çapındaki kavelalar, 25 mm derinlikte delikler açılarak PVAc tutkalı ile yapıştırılmıştır. Hazırlanan örneklere aynı amaçla yapılmış bir çalışma örnek alınarak çekme deneyi uygulanmış ve kavela çapı ile masif malzeme kalınlığının kavela çekme direncine etkileri araştırılmıştır. Sonuç olarak kavela çekme direnci; en yüksek ? 6 mm kavela ve 8 mm kalınlıkta masifli MDF?de (2.294 N/mm 2 , en düşük ?10 mm kavela ve masifsiz MDF?de (1.314 N/mm 2 gerçekleşmiştir.

  20. An online photographic catalog of primary types of Platygastroidea (Hymenoptera in the National Museum of Natural History, Smithsonian Institution

    Directory of Open Access Journals (Sweden)

    Elijah J. Talamas

    2017-06-01

    Full Text Available A photographic catalog of primary types of Platygastroidea housed in the National Insect Collection, National Museum of Natural History, is here made available online at the image database at The Ohio State University (specimage.osu.edu. Following examination of this collection we enact the following taxonomic changes: Leptacis piniella MacGown syn. n. is treated as a junior synonym of Leptacis pinicola MacGown; Sacespalus indicus Mani is transferred to Platygaster Latreille; Platygaster indica Mukerjee is given the replacement name Platygaster chaos Talamas, n. n.; Synopeas rugiceps (Ashmead, comb. n. is transferred from Leptacis Förster; Axea atriclava (Kieffer, comb. n. is transferred from Psilanteris Kieffer; Chakra pachmarhica (Sharma, comb. n. is transferred from Paridris Kieffer; Paridris dubeyi Sharma, syn. n. is treated as a junior synonym of Chakra pachmarhica; Holoteleia indica (Mani is transferred to Opisthacantha Ashmead and given a replacement name, Opisthacantha nomados Talamas, n. n.; Psilanteris nigriclavata (Ashmead, comb. n. is transferred from Anteris Förster; Probaryconus grenadensis (Ashmead, comb. n. is transferred from Monoteleia Kieffer; Monoteleia syn.n. is treated as a junior synonym of Probaryconus Kieffer; Paridris karnatakensis Sharma, syn. n is treated as a junior synonym of Probaryconus cauverycus Saraswat; Probaryconus punctatus (Ashmead, comb. n. is transferred from Oxyteleia Kieffer; Triteleia bengalensis (Saraswat, comb. n. is transferred from Alloteleia Kieffer; Trimorus varius Fouts, syn. n. and Trimorus pulchricornis Fouts, syn. n. are treated as junior synonyms of Trimorus annulicornis (Ashmead; Neotypes are designated for Gryon leptocorisae (Howard, Idris seminiger (Ashmead, Telenomus graptae Howard, Telenomus persimilis Ashmead, and Telenomus rileyi Howard; lectotypes are designated for Cremastobaeus bicolor Ashmead, Oethecoctonus insularis (Ashmead, Oethecoctonus laticinctus (Ashmead and Probaryconus

  1. Comparative NIR Detector Characterization for NGST

    Science.gov (United States)

    Greenhouse, Matthew (Technical Monitor); Figer, Donald

    2004-01-01

    List of publications for final perfomance report are: Detectors for the JWST Near-Infrared Spectrometer Rauscher, B.J., Strada, P., Regan, M.W., Figer, D.F., Jakobsen, P., Moseley, H.S., & Boeker, T. 2004, SPIE Detectors for the JWST Near-Infrared Spectrometer Rauscher, B.J., Strada, P., Regan, M.W., Figer, D.F., Jakobsen, P., Moseley, H.S., & Boeker, T. 2004, AAS, 203, 124.07 Independent Testing of JWST Detector Prototypes Figer, D.F., Rauscher, B. J., Regan, M. W., Morse, E., Balleza, J., Bergeron, L., & Stockman, H. S. 2003 , SPIE, 5 167 The Independent Detector Testing Laboratory and the NGST Detector Program Figer, D.F., Agronin, M., Balleza, J., Barkhouser, R., Bergeron, L., Greene, G. R., McCandliss, S. R., Rauscher, B. J., Reeves, T., Regan, M. W., Sharma, U., Stockman, H. S. 2003, SPIE, 4850,981 Intra-Pixel Sensitivity in NIR Detectors for NGST Sharma, U., Figer, D.F., Sivaramakrishnan, A., Agronin, M., Balleza, J., Barkhouser, R., Bergeron, L., Greene, G. R., McCandliss, S. R., Rauscher, B. J., Reeves, T., Regan, M. W., Stockman, H. S. 2003, SPIE, 4850,1001 NIRCAM Image Simulations for NGST Wavefiont SensinglPS A. Sivaramakrishnan, D. Figer, H. Bushouse, H. S. Stockman (STScI),C. Ohara , D. Redding (JPL), M. Im (IPAC), & J. Offenberg (Raytheon) 2003, SPIE, 4850,388 Ultra-Low Background Operation of Near-Infrared Detectors for NGS Rauscher, B. J., Figer, D. F., Agronin, M., Balleza, J., Barkhouser, R., Bergeron, L., Greene, G. R., McCandliss, S. R., Reeves, T., Regan, M. W., Sharma, U., Stockman, H. S. 2003, SPIE, 4850,962 The Independent Detector Testing Laboratory and the JWST Detector Program Figer, D.F. et a1.2003, AAS201, #131.05

  2. Characteristics of Optic Nerve Damage Induced by Chronic Intraocular Hypertension in Rat

    Institute of Scientific and Technical Information of China (English)

    Jiantao Wang; Jian Ge; A.A. Sadun; T.T. Lam

    2004-01-01

    Purpose:To set up the Sharma's chronic intraocular hypertension model and investigate the intraocular pressure (lOP) as well as the optic nerve damage of this model in rat.Methods:The operations of the chronic intraocular hypertension model were performed as described by Sharma in 60 male Lewis albino rats. IOP was measured using the TonoPen XL immediately after surgery and then at 5 day, 2 week or 4 week intervals. Cresyl violet staining of whole-mounted retinas was used to label retinal ganglion cells (RGCs),then RGCs were counted. Paraphenylenediamine (PPD) staining was performed in the semi-thin cross sections of optic nerve of rat, in order to know whether the axons of optic nerve were degenerated or not. Results:There were 47 rats with higher IOP after the episcleral veins cauterized in 60rats. The ratio of elevated IOP was 78.3%. The IOPs were stable in 4 weeks. After cresyl violet staining, the RGCs loss was 11.0% and 11.3% was found in the central and peripheral retina respectively after 2 weeks of increased IOP. After 4 weeks of increased lOP, the loss of RGCs was 17% for the central retina and 24.6% for the peripheral retina. In the retinas without higher IOP, there was no loss of RGCs. PPD staining showed that optic nerve of rat with about 5.3% damage of axons located at the superior temporal region. Region of affected optic nerve 1 mm posterior to the globe by light microscope showed evidence of damaged axons with axonal swelling and myelin debris.Conclusion:Sharma's chronic intraocular hypertension model is a reproducible and effective glaucoma model, which mimics human glaucoma with chronically elevation IOP and induced RGCs loss and damage of optic nerve. Eye Science 2004;20:25-29.

  3. Development of merchantable volume equations for natural brutian pine and black pine stands in Eğirdir District

    Directory of Open Access Journals (Sweden)

    Ramazan Özçelik

    2016-01-01

    Full Text Available Determination of stem standing volume is very useful for both sustainable management of timber resources and practical purposes in forestry. Brutian pine (Pinus brutia Ten. and black pine (Pinus nigra Arnold. are important raw material of forest products industry of Turkey. With ever changing market conditions, there is a need to accurately estimate tree volumes utilizing multiple upper stem merchantability limits. This is not currently possible with the existing total stem volume tables for these three species. Nowadays, taper equations are the best way to estimate volume for saw timber and biomass purposes. In this study, variable exponent taper equations evaluated and fitted to data come from 253 destructively sampled trees which were collected in natural brutian pine and black pine stands in Eğirdir district. For this aim, the taper equations of Lee et al. (2003, Kozak (2004, and Sharma and Zhang (2004 were used. A second-order continuous-time autoregressive error structure was used to correct the inherent autocorrelation in the hierarchical data. The proposed models generally performed better for Merchantable tree volume. Results show that the Kozak (2004 taper equation was superior to the other equations in predicting diameter and merchantable height, while The Sharma and Zhang (2004 taper model provided the best predictions for merchantable volume than the other models. The one of the important results of this study, the importance of checking fit statistics of taper equations for both diameters and volume estimations.As a results, Sharma and Zhang (2004 taper model recommended for estimating diameter at a specific height, height to a specific diameter along the stem, and merchantable volume for brutian pine and black pine stands in Eğirdir analyzed

  4. Diffusivity in silicon 1953 to 2009

    CERN Document Server

    Fisher, David J

    2010-01-01

    This work is essentially an update of previous compilations of information on the diffusivity of elements in semiconductor-grade silicon. It subsumes the data contained in B.L.Sharma's monograph on 'Diffusion in Semiconductors' (Trans Tech Publications, 1970), plus the data contained in Diffusion and Defect Data (Diffusion in Silicon) Volume 45 (1986), Defect and Diffusion Forum (Diffusion in Silicon - 10 years of Research) Volumes 153-155 (1998), Defect and Diffusion Forum (Diffusion in Silicon - a Seven-Year Retrospective) Volume 241 (2005) and the latest data from recent Semiconductor Retro

  5. Low-dimensional representations of exact coherent states of the Navier-Stokes equations

    CERN Document Server

    Sharma, Ati S; McKeon, Beverley J; Park, Jae Sung; Graham, Michael D; Willis, Ashley P

    2015-01-01

    We report that many exact invariant solutions of the Navier-Stokes equations for both pipe and channel flows are well represented by just few modes of the model of McKeon & Sharma J. Fl. Mech. 658, 356 (2010). This model provides modes that act as a basis to decompose the velocity field, ordered by their amplitude of response to forcing arising from the interaction between scales. The model was originally derived from the Navier-Stokes equations to represent turbulent flows. This establishes a new link between the exact invariant solutions and the theory of turbulent flow and provides new evidence of the former's continuing organising importance in that regime.

  6. Product Summability Transform of Conjugate Series of Fourier Series

    Directory of Open Access Journals (Sweden)

    Vishnu Narayan Mishra

    2012-01-01

    Full Text Available A known theorem, Nigam (2010 dealing with the degree of approximation of conjugate of a signal belonging to Lipξ(t-class by (E,1(C,1 product summability means of conjugate series of Fourier series has been generalized for the weighted W(Lr,ξ(t, (r≥1,(t>0-class, where ξ(t is nonnegative and increasing function of t, by En1Cn1~ which is in more general form of Theorem 2 of Nigam and Sharma (2011.

  7. Nordic Noir - Location, Identity and Emotion

    DEFF Research Database (Denmark)

    Agger, Gunhild

    2016-01-01

    Understanding and discussing the impact of the Nordic element in ‘Nordic Noir’ is the main purpose of this article. This is pursued by tracing the concepts of location, identity and emotion in selected episodes of TV series and serials representative of Nordic Noir – Wallander (2005-) Forbrydelsen...... and emotion (Sharma & Dahl 2013, Tygstrup 2013, Pribram 2011, Laine 2011). Their concepts are applied in the analyses. The article concludes with a perspective considering the role of Nordic Noir vis-à-vis international TV drama productions....

  8. Editorial

    DEFF Research Database (Denmark)

    Audoly, Basile; Castañeda, Pedro Ponte; Kuhl, Ellen;

    2016-01-01

    After 12 years of distinguished service, Kaushik Bhattacharya has decided to step down as co-editor of the Journal of the Mechanics and Physics of Solids. A new editorial team, with Huajian Gao as editor and Basile Audoly, Pedro Ponte Castañeda, Ellen Kuhl, Christian Niordson and Pradeep Sharma...... of the editorial board for the Journal. He wisely steered the Journal through a rapidly evolving research landscape with his personal dedication, fairness, scientific judgment and open-mindedness. While being an editor of JMPS, he maintained a prolific research activity and also took on significant leadership...

  9. Symmetry analysis of a system of modified shallow-water equations

    CERN Document Server

    Szatmari, Simon

    2012-01-01

    We revise the symmetry analysis of a modified system of one-dimensional shallow-water equations (MSWE) recently considered by Raja Sekhar and Sharma [Commun. Nonlinear Sci. Numer. Simulat. 20 (2012) 630-636]. Only a finite dimensional subalgebra of the maximal Lie invariance algebra of the MSWE, which in fact is infinite dimensional, was found in the aforementioned paper. The MSWE can be linearized using a hodograph transformation. An optimal list of inequivalent one-dimensional subalgebras of the maximal Lie invariance algebra is constructed and used for Lie reductions. Non-Lie solutions are found from solutions of the linearized MSWE.

  10. Acute effects of alcohol on sleep are mediated by components of homeostatic sleep regulatory system: An Editorial Highlight for 'Lesions of the basal forebrain cholinergic neurons attenuates sleepiness and adenosine after alcohol consumption' on page 710.

    Science.gov (United States)

    Alam, Md Noor; McGinty, Dennis

    2017-09-01

    Alcohol causes adenosine buildup, which inhibits wake-active neurons via adenosine A1 receptors thus disinhibiting sleep active neurons and also stimulates sleep-active neurons via A2A receptors, causing sleep. This editorial highlights the study entitled, "Lesions of the basal forebrain cholinergic neurons attenuates sleepiness and adenosine after alcohol consumption" by Sharma and colleagues. They report that the wake-promoting basal forebrain (BF) cholinergic neurons play a crucial role in mediating acute alcohol-induced sleep via adenosinergic signaling. © 2017 International Society for Neurochemistry.

  11. Defects and diffusion in semiconductors XII

    CERN Document Server

    Fisher, David J

    2010-01-01

    This twelfth volume in the series covering the latest results in the field includes abstracts of papers which have appeared since the publication of Annual Retrospective XI (Volume 282). As well as the 565 semiconductor-related abstracts, the issue includes - in line with the policy of including original papers on all of the major material groups: ""Study of Conduction Mechanism in Amorphous Se85-xTe15Bix Thin Films"" (A.Sharma and P.B.Barman), ""Structure and Optical Properties of Magnetron-Sputtered SiOx Layers with Silicon Nanoparticles"" (L.Khomenkova, N.Korsunska, T.Stara, Y.Goldstein, J.

  12. Near East/South Asia Report

    Science.gov (United States)

    2007-11-02

    THE HINDU in English 17 Mar 85 p 12 [Text] ^’^St^pft^ Afivenrierriber Congress (D Ministry,’foraded ■by MK M; O. H Farbok^artt^/Wäs ^installed...Governor, Mr K.M. Chandy, at a function in the Raj Bhavan here are: Mr Shiv VhanU Singh Solanki, Dr K.L. Sharma, Mr Balendu Shukla and Mr Durgadas...Mr Shyama Charan Shukla .—UNI [Text] [Madras THE HINDU in English 23 Mar 85 p 9] 1ND0-NEPAL PACT EXTENDED—New Delhi, March 22—The existing treaty of

  13. Influence of seabed topography on the distribution of manganese nodules and associated features in the Central Indian Basin: A study based on photographic observations

    Digital Repository Service at National Institute of Oceanography (India)

    Sharma, R.; Kodagali, V.N.

    ) 153-162 153 Elsevier Science Publishers B.V., Amsterdam Influence of seabed topography on the distribution of manganese nodules and associated features in the Central Indian Basin: A study based on photographic observations Rahul Sharma and V... and associated features in the Central Indian Basin: A study based on photographic observations. Mar. Geol., 110: 153-162. The distribution of manganese nodules and associated rock outcrops and sediment cover in the Central Indian Basin (10°-16°S, 73°-82°E...

  14. Regular

    Indian Academy of Sciences (India)

    Ratanpal B S; Sharma Jaita

    2016-03-01

    The charged anisotropic star on paraboloidal space-time is reported by choosing a particular form of radial pressure and electric field intensity. The non-singular solution of Einstein–Maxwell system of equation has been derived and it is shown that the model satisfies all the physical plausibility conditions. It is observed that in the absence of electric field intensity, the model reducesto a particular case of uncharged Sharma and Ratanpal model. It is also observed that the parameter used in the electric field intensity directly affects mass of the star.

  15. A review of the genus Paraleptomenes Giordani Soika, 1970 (Hymenoptera: Vespidae: Eumeninae: Odynerini) from the Indian subcontinent,with the description of a new species from the eastern Himalayas.

    Science.gov (United States)

    Kumar, Girish P; Carpenter, James M; Sharma, Gaurav

    2014-05-23

    The genus Paraleptomenes Giordani Soika, 1970 is reviewed for the Indian subcontinent. A new species Paraleptomenes darugiriensis Kumar, Carpenter & Sharma, sp. nov. is described. The male of P. rufoniger Giordani Soika, 1994 is described for the first time. The distribution records of P. humbertianus (de Saussure, 1867), P. miniatus mephitis (Cameron, 1901), P. miniatus miniatus (de Saussure, 1855), and P. rufoniger Giordani Soika, 1994 in the Indian states are augmented. A key to species of the Indian subcontinent and a world checklist of species are provided.

  16. An introduction to biomaterials

    CERN Document Server

    Hollinger, Jeffrey O

    2011-01-01

    Consensus Definitions, Fundamental Concepts, and a Standardized Approach to Applied Biomaterials Sciences, J.O. HollingerBiology, Biomechanics, Biomaterial Interactions: Wound Healing BiologyCutaneous Wound Pathobiology: Raison d'etre for Tissue Engineering, L.K. Macri and R.A.F. ClarkOsseous Wound Healing, A. Nawab, M. Wong, D. Kwak, L. Schutte, A. Sharma, and J.O. HollingerBiology, Biomechanics, Biomaterial Interactions: Cellular MechanicsCell and Tissue Mechanobiology, W. Guo, P. Alvarez, and Y. WangBiology, Biomechanics, Biomaterial Interactions: Materials-Host InteractionsCell-Material In

  17. UNA EXPLICACIÓN DEL EFECTO HERDING DESDE EL MERCADO DE DERIVADOS

    OpenAIRE

    NATIVIDAD BLASCO DE LAS HERAS; SANDRA FERRERUELA GARCÉS; PILAR CORREDOR CASADO

    2010-01-01

    El objetivo de este trabajo es contribuir a la explicación del comportamiento imitador (herding) aportando la perspectiva del mercado de derivados. Para ello se analiza la intensidad de herding en el mercado de contado en momentos especialmente relevantes en el mercado de derivados como es el vencimiento. La medida de herding empleada es la propuesta por Patterson y Sharma (2006). El periodo analizado comprende desde el año 1997 hasta el 2003, lo que permite estudiar aspectos como la madurez ...

  18. Rayleigh lidar observations of double stratopause structure over three different northern hemisphere stations

    CSIR Research Space (South Africa)

    Sivakumar, V

    2006-09-01

    Full Text Available observations of double stratopause structure over three different northern hemisphere stations V. Sivakumar1, H. Bencherif1, A. Hauchecorne2, P. Keckhut2, D. N. Rao3, S. Sharma4, H. Chandra4, A. Jayaraman4, and P. B. Rao5 1Laboratoire de l’Atmosphe`re et... des Cyclones, CNRS–UMR 8105, Universite´ de La Re´union, La Reunion, France 2Service d’Ae´ronomie, CNRS, Paris, France 3National Atmospheric Research Laboratory, P. B. No: 123, Tirupati-517 502, India 4Physical Research Laboratory, Navarangapura...

  19. Electronic Band Structures and Optical Properties of Type-II Superlattice Photodetectors with Interfacial Effect

    Science.gov (United States)

    2012-01-18

    MWIR and LWIR superlattice photodiodes,” Infrared Phys. Techn. 50, 187–190 (2007). 21. A. Khoshakhlagh, E. Plis, S. Myers, Y. D. Sharma, L. R. Dawson...quantum efficiency (QE) spectra [19,20] for a mid-wave infrared (MWIR) detector with a 3.6 μm cutoff wavelength and a long-wave infrared detector ( LWIR ...1016 cm−3 (dashed), NA = 5×1015 cm−3 (solid). different thicknesses, and the calibration is automatically included during the spectral response

  20. Conditional Second Order Short-crested Water Waves Applied to Extreme Wave Episodes

    DEFF Research Database (Denmark)

    Jensen, Jørgen Juncher

    2005-01-01

    A derivation of the mean second order short-crested wave pattern and associated wave kinematics, conditional on a given magnitude of the wave crest, is presented. The analysis is based on the second order Sharma and Dean finite water wave theory. A comparison with a measured extreme wave profile......, the Draupner New Year Wave, shows a good agreement in the mean, indicating that this second order wave can be a good identifier of the shape and occurrence of extreme wave events. A discussion on its use as an initial condition for a fully non-linear three-dimensional surface wave analysis is given....

  1. Low-dimensional representations of exact coherent states of the Navier-Stokes equations from the resolvent model of wall turbulence.

    Science.gov (United States)

    Sharma, Ati S; Moarref, Rashad; McKeon, Beverley J; Park, Jae Sung; Graham, Michael D; Willis, Ashley P

    2016-02-01

    We report that many exact invariant solutions of the Navier-Stokes equations for both pipe and channel flows are well represented by just a few modes of the model of McKeon and Sharma [J. Fluid Mech. 658, 336 (2010)]. This model provides modes that act as a basis to decompose the velocity field, ordered by their amplitude of response to forcing arising from the interaction between scales. The model was originally derived from the Navier-Stokes equations to represent turbulent flows and has been used to explain coherent structure and to predict turbulent statistics. This establishes a surprising new link between the two distinct approaches to understanding turbulence.

  2. Artifact versus arrhythmia in pseudo-polymorphic tachycardia; case report

    Directory of Open Access Journals (Sweden)

    Ahmed V

    2015-04-01

    Full Text Available Vaseem Ahmed, Anish Patel, Abhishek Sharma, Dennis Bloomfield Department of Medicine, Richmond University Medical Center, Staten Island, NY, USA Abstract: We present the case of a young male patient in sinus rhythm whose electrocardiogram (ECG was initially misinterpreted as ventricular tachycardia. Electrocardiographic artifact appearing to be ventricular tachycardia commonly occurs and ECG criteria have been described to aid in the discrimination between artifact and true arrhythmia. There are many causes of artifacts and prompt recognition is important to prevent unnecessary interventions. Keywords: artifact, ventricular tachycardia, pseudo-ventricular tachycardia, notch sign, sinus sign

  3. Airflow and Contaminant Distribution in Hospital Wards with a Displacement Ventililation System

    DEFF Research Database (Denmark)

    Qian, H.; Nielsen, Peter Vilhelm; Li, Y.

    2004-01-01

    an appropriate turbulent model to simulate and reproduce the process of contaminant dispersion. The low Reynolds-number (LRN) k-e (Launder and Sharma, 1978) turbulence model with a damping function (Chikamoto et al., 1992) was considered and evaluated by experiment. We carried out an experimental study to test...... wards probably due to its inability to remove large particles and risk of particle deposition on horizontal surfaces in the occupied regions. However, the existing downward ventilation system commonly used in isolation rooms does not deliver the required performance. There is a need to develop effective...

  4. Thermo elastic waves with thermal relaxation in isotropic micropolar plate

    Indian Academy of Sciences (India)

    Soumen Shaw; Basudeb Mukhopadhyay

    2011-04-01

    In the present investigation, we have discussed about the features of waves in different modes of wave propagation in an infinitely long thermoelastic, isotropic micropolar plate, when the generalized theory of Lord–Shulman (L–S) is considered. A more general dispersion equation is obtained. The different analytic expressions in symmetric and anti-symmetric vibration for short as well as long waves are obtained in different regions of phase velocities. It is found that results agree with that of the existing results predicted by Sharma and Eringen in the context of various theories of classical as well as micropolar thermoelasticity.

  5. Charged Anisotropic Star on Paraboloidal Spacetime

    CERN Document Server

    Ratanpal, B S

    2015-01-01

    The charged anisotropic star on paraboloidal spacetime is reported by choosing particular form of radial pressure and electric field intensity. The non-singular solution of Einstein-Maxwell system of equation have been derived and it is shown that model satisfy all the physical plausibility conditions. It is observed that in the absence of electric field intensity, model reduces to particular case of uncharged Sharma \\& Ratanpal model. It is also observed that the parameter used in electric field intensity directly effects the mass of the star.

  6. Veeravalli Venkata Ranga Varadachari (01 July 1925- 04 August 2007)

    Digital Repository Service at National Institute of Oceanography (India)

    Murty, C.S.

    of the doctoral degree by the members of the board of adjudicators - Sir George Deacon from UK, Professor Walter H Munk from USA - for the dissertation submitted in geophysics. PROFESSIONAL CAREER VVR had an in-born passion towards teaching. According to his own... for their doctoral dissertation work in India and made significant progress in research and in teaching faculties. These include Dr C Balarama Murty (Defence R&D, GOI); Prof, GS Sharma (ex-Cochin Univ.); Prof. PG Kurup and Mr. B Rami Reddy (Cochin Univ.) Prof. MPM...

  7. Defects and diffusion in semiconductors XIII an annual retrospective

    CERN Document Server

    Fisher, D J

    2011-01-01

    This thirteenth volume in the series covering the latest results in the field includes abstracts of papers which have appeared since the publication of Annual Retrospective XII (Volumes 303-304). As well as the over 300 semiconductor-related abstracts, the issue includes the original papers: ""Effect of KCl Addition upon the Photocatalytic Activity of Zinc Sulphide"" (D.Vaya, A.Jain, S.Lodha, V.K.Sharma, S.C.Ameta), ""Localized Vibrational Mode in Manganese-Doped Zinc Sulphide and Cadmium Sulphide Nanoparticles"" (M.Ragam, N.Sankar, K.Ramachandran), ""The Effect of a Light Impurity on the Elec

  8. 6063铝合金氧化膜与CsF-AlF3及KF-AlF3钎剂的反应机制%Mechanism of CsF-AIF3 and KF-AIF3 fluxes reacting with oxide films of 6063 aluminum alloy

    Institute of Scientific and Technical Information of China (English)

    朱宏; 薛松柏; 盛重

    2009-01-01

    选用CsF-AlF3和KF-AlF3钎剂,研究了两种钎剂在6063铝合金表面不同温度下的去膜效果,并分析和探讨了钎剂与6063铝合金表面氧化膜的反应机制.研究发现,CsF-AlF3,钎剂是以反应、溶解的机制去除6063铝合金表面氧化膜的,NHIF在高温下生成的HF是CsF-AlF3钎剂去膜的关键化合物.此外,H2O的存在或形成促进了HF的生成,从而加速了钎剂的去膜进程.CsF-AlF3,,钎剂反应产物中没有发现CsF和AlF3,只有少量的CsAlF4存在.在570℃下,KF-AlF3钎剂反应产物中以KAlF4为主,而在610℃条件下,KAlF4已不存在,只有少量的KMgF3生成.结果表明,在610℃条件下,Mg,Mn元素和KAlF4将逐渐地消耗掉,使得钎剂熔点急剧升高,导致钎剂流动性变差.

  9. Anosmin-1 contributes to brain tumor malignancy through integrin signal pathways

    Science.gov (United States)

    Choy, Catherine T; Kim, Haseong; Lee, Ji-Young; Williams, David M; Palethorpe, David; Fellows, Greg; Wright, Alan J; Laing, Ken; Bridges, Leslie R; Howe, Franklyn A; Kim, Soo-Hyun

    2014-01-01

    Anosmin-1, encoded by the KAL1 gene, is an extracellular matrix (ECM)-associated protein which plays essential roles in the establishment of olfactory and GNRH neurons during early brain development. Loss-of-function mutations of KAL1 results in Kallmann syndrome with delayed puberty and anosmia. There is, however, little comprehension of its role in the developed brain. As reactivation of developmental signal pathways often takes part in tumorigenesis, we investigated if anosmin-1-mediated cellular mechanisms associated with brain tumors. Our meta-analysis of gene expression profiles of patients' samples and public microarray datasets indicated that KAL1 mRNA was significantly upregulated in high-grade primary brain tumors compared with the normal brain and low-grade tumors. The tumor-promoting capacity of anosmin-1 was demonstrated in the glioblastoma cell lines, where anosmin-1 enhanced cell motility and proliferation. Notably, anosmin-1 formed a part of active β1 integrin complex, inducing downstream signaling pathways. ShRNA-mediated knockdown of anosmin-1 attenuated motility and growth of tumor cells and induced apoptosis. Anosmin-1 may also enhance the invasion of tumor cells within the ECM by modulating cell adhesion and activating extracellular proteases. In a mouse xenograft model, anosmin-1-expressing tumors grew faster, indicating the role of anosmin-1 in tumor microenvironment in vivo. Combined, these data suggest that anosmin-1 can facilitate tumor cell proliferation, migration, invasion, and survival. Therefore, although the normal function of anosmin-1 is required in the proper development of GNRH neurons, overexpression of anosmin-1 in the developed brain may be an underlying mechanism for some brain tumors. PMID:24189182

  10. Gene expression profile in the muscles of patients with inflammatory myopathies: effect of therapy with IVIg and biological validation of clinically relevant genes.

    Science.gov (United States)

    Raju, Raghavan; Dalakas, Marinos C

    2005-08-01

    To explore the biological significance of gene expression in the pathogenesis of inflammatory myopathies, we performed microarray experiments followed by real-time PCR and immunohistochemistry on muscle biopsies obtained before and after therapy from patients with dermatomyositis (DM) who improved and patients with inclusion body myositis (sIBM) who did not improve after controlled trials with three monthly intravenous immunoglobulin (IVIg) infusions. The pretreatment biopsies showed high expression of immunoglobulin, adhesion molecules, chemokines and cytokine genes in both sIBM and DM (sIBM > DM). In the repeated biopsies of DM patients who clinically improved, 2206 genes were downregulated more than 1.5-fold; in contrast, 1700 of the same genes remained unchanged in sIBM patients who did not improve. Genes markedly downregulated in DM, but not sIBM, were interleukin 22, Kallmann syndrome 1 (KAL-1), an adhesion molecule shown for the first time in muscle, ICAM-1, complement C1q, and several structural protein genes. Because mRNA for KAL-1 was selectively upregulated in vitro by transforming growth factor (TGF) beta1, a fibrogenic cytokine immunolocalized in the endomysial connective tissue of pretreatment DM muscles, the downregulation of both TGF-beta and KAL-1 after IVIg only in DM suggests that these molecules have a functional role in connective tissue proliferation and fibrosis. The improved muscles of DM, but not sIBM, showed upregulation of chemokines CXCL9 (Mig) and CXCL11, and several immunoglobulin-related genes, suggesting an effect on muscle remodelling and regeneration. The results suggest that IVIg modulates several immunoregulatory or structural muscle genes, but only a subset of them associated with inflammatory mediators, fibrosis and muscle remodelling are connected with the clinical response. Gene arrays, when combined with clinical assessments, may provide important information in the pathogenesis of inflammatory myopathies.

  11. Global navigation satellite systems, inertial navigation, and integration

    CERN Document Server

    Grewal, Mohinder S; Bartone, Chris G

    2013-01-01

    An updated guide to GNSS, and INS, and solutions to real-world GNSS/INS problems with Kalman filtering Written by recognized authorities in the field, this third edition of a landmark work provides engineers, computer scientists, and others with a working familiarity of the theory and contemporary applications of Global Navigation Satellite Systems (GNSS), Inertial Navigational Systems, and Kalman filters. Throughout, the focus is on solving real-world problems, with an emphasis on the effective use of state-of-the-art integration techniques for those systems, especially the application of Kal

  12. SUPPRESSION OF LIGASE4 OR XRCC6 ACTIVITIES ENHANCES THE DNA HOMOLOGOUS RECOMBINATION EFFICIENCY IN ZEBRAFISH PRIMORDIAL GERM CELLS%抑制Ligase4或Xrcc6活性增强斑马鱼原始生殖细胞中DNA同源重组的效率

    Institute of Scientific and Technical Information of China (English)

    魏志强; 熊凤; 何牡丹; 王厚鹏; 朱作言; 孙永华

    2015-01-01

    Primordial germ cells (PGCs) give rise to gametes which transmit the genetic information to next generation, therefore PGCs provide us an ideal cell type for genetic manipulation. Homologous recombina-tion (HR) is the most efficient technique to create designed genetic modifications, however, its efficiency is rather low in vertebrates. In this study, by using zebrafish as an in vivo model, we aimed to enhance the effi-ciency of HR in zebrafish PGCs. First, we injected UAS:mRFP-nos1 construct into Tg (kop:KalTA4) embryos to label the transgenic PGCs, and we showed that screening of PGCs-specific mRFP expression led to rela-tively high-efficient germline transmission of transgene. Then we established an in vivo assay to evaluate the HR frequency in PGCs. We further revealed that suppression of the activities of DNA ligase IV (Lig4) and Xrcc6 (previously known as Ku70) could significantly increase the HR efficiency, not only at whole embryo level but also in PGCs. We proposed that the Tg(kop:KalTA4) line could be used as an effective platform for HR-mediated gene targeting.%利用斑马鱼作为体内模型,研究旨在提高斑马鱼原始生殖细胞(Primordial germ cells, PGCs)中同源重组(Homologous recombination, HR)的效率。首先,将 UAS:mRFP-nos1载体显微注射到 Tg (kop:KalTA4)转基因胚胎中标记转基因PGCs,结果表明筛选PGCs特异表达mRFP的胚胎能够相对提高转基因的生殖系传递效率。随后建立了 PGCs 中 HR 效率的评估体系,并且证明抑制 DNA ligase IV(Lig4)和Xrcc6(曾用名Ku70)的活性不但在全胚胎水平,而且在PGCs水平都能够显著提高HR的效率。研究表明Tg (kop:KalTA4)转基因品系是开展HR介导的基因打靶的一个有效平台。

  13. Chinese-English Electronics and Telecommunications Dictionary. Volume 1

    Science.gov (United States)

    1976-06-01

    Jao rac kung gong ho ha ** ra to. guo hou hou jan ran k’a k. M xi Jang rang k’al kal haU xla Jih rl k’an kan haiang xlang Jo ruo k’ang kang...repeating signal 30 fuahu «» complex number 31 fuahu changfa M«f*!£ complex multiplication 32 468 *-£Z. ■>!».- ^Sfci •vim fuahu chengfa Jlcunqi... guo ]i dlanbao zlmu guojl dlanhuaju guojl dianlu guojl dlanma Guojl dlanma xlnhao guojl dlanxln yevu guojl fala tu m i Öä lif- ^ « i^i»j

  14. Ammonium ytterbium(III diphosphate(V

    Directory of Open Access Journals (Sweden)

    Michal Dušek

    2008-12-01

    Full Text Available The title compound, NH4YbP2O7, crystallizes in the KAlP2O7 structure type and consists of distorted YbO6 octahedra and bent P2O74− diphosphate units forming together a three-dimensional network. There are channels in the structure running along the c axis, where the NH4+ cations are located. They are connected via N—H...O hydrogen bonds to the terminal O atoms of the diphosphate anions.

  15. Theoretical Study on Reaction Mechanism of H2S with Hydroxide Radical and Cl in the Absence and Presence of Water Molecule%理论研究H2S与羟基和Cl在没有水分子和有水分子条件下的反应机理

    Institute of Scientific and Technical Information of China (English)

    毛文雪; 隆正文

    2011-01-01

    The quantum chemical calculations were applied to study the two reactions of Cl + H2S and OH + H2S without water and with a single water molecule. The computed results predict that the activated barriers for two reactions of Cl + H2S and OH + H2S are reduced by 4.3 kal/mol and 3.6 kal/mol respectively. In addition, the calculated results show that the rate constant are increased by 2.5 × 10-9cm3 molecule-1 s-1 and increased 5.18× 10-12cm3 molecule-1 s-1, respectively. The calculation results agree well with theoretical value of literature.Thus, the calculations show that the single water would play a catalytic role in the reaction of Cl + H2S , but pro duce negative influence to the reaction of OH + H2S.%本文用量子化学计算方法研究没有水分子和有水分子条件下对Cl+H2S和OH+H2S这两个反应产生的影响.在wb97xd/aug-cc-pvtz水平下的计算结果表明,单个水分子加到反应中会使Cl+H2S和OH+H2S这两个反应的能垒分别减小3.0kal/mol和2.2kal/mol.同时两个反应的速率常数在水分子影响下也分别增加了2.5×10-9cm3 molecule-1s-1和减小了5.18×10-12cm3 molecule-1s-1,计算结果和文献理论值符合得很好.说明水分子对Cl+H2S反应体系有催化的效果,对OH+H2S反应体系没有催化的效果,反而具有减缓反应.

  16. Eco-friendly and efficient one-pot synthesis of alkyl- or aryl-14H-dibenzo[a,j]xanthenes in water.

    Science.gov (United States)

    Dabiri, Minoo; Baghbanzadeh, Mostafa; Nikcheh, Maryam Shakouri; Arzroomchilar, Elham

    2008-01-01

    Alkyl- or aryl-14H-dibenzo[a,j]xanthene derivatives are synthesized efficiently by the reaction of beta-naphthol and aliphatic and aromatic aldehydes in the presence of KAl(SO4)2 x 12 H2O (alum) under aqueous condition at 100 degrees C. Different types of aromatic and aliphatic aldehydes are used in the reaction and in all cases the products synthesized successfully. Several solvents were examined for this reaction; however, in terms of reaction yield and time, water was found to be the optimum solvent.

  17. Characterization of the lapis lazuli from the Egyptian treasure of Tôd and its alteration using external μ-PIXE and μ-IBIL

    Science.gov (United States)

    Calligaro, T.; Coquinot, Y.; Pichon, L.; Pierrat-Bonnefois, G.; de Campos, P.; Re, A.; Angelici, D.

    2014-01-01

    Lapis lazuli is among the earliest and most priced ornamental stone worked to produce carvings, beads and inlays as early as the 4th millennium BC. It is an heterogeneous rock composed of blue lazurite Na3Ca(Si3Al3O12)S mixed with other minerals like calcite, diopside and pyrite. The historical source of lapis lazuli in antiquity is supposedly located in Afghanistan, in the Sar-e-Sang district, while other sources are known in Tajikistan and Russia (Baïkal area).

  18. La Didáctica de la Literatura en Colombia: un caleidoscopio en construcción

    Directory of Open Access Journals (Sweden)

    Mónica Moreno Torres

    2011-12-01

    Full Text Available El concepto de caleidoscopio proviene del griego kalós -bella- , éidos –imagen- y scopéo -observar-. Esta triada ";imagológica"; permite sustentar cómo al analizar algunas concepciones de la didáctica de la literatura en Colombia aparecen diversas relaciones y enfoques de esta disciplina en construcción. Sus tonalidades y énfasis ponen en movimiento singulares preguntas que quedaran esbozadas en el presente artículo.

  19. [X-linked Kallmann's syndrome: intra and interfamilial heterogeneity].

    Science.gov (United States)

    Vidal, Alfonso; Loidi, Lourdes; Colino, Esmeralda; del Carmen Miranda, María; Barrio, Raquel

    2007-05-26

    Hypogonadotropic hypogonadism and anosmia characterize Kallmann's syndrome, whose X-linked form is due to mutations in the KAL1 gene. We studied a family with 6 affected members. We compare their clinical (chryptorchidism, micropenis, puberty, associated malformations), analytical (gonadotrophin releasing hormone test, and human chorionic gonadotropin test), genetic (cariotype), and radiological data of the described familiar cases with other reported sporadic cases. The described cases carried the R191X mutation. We found phenotypic heterogeneity between the patients. We report the first familiar cases of Kallmann's syndrome due to the R191X mutation. Probably other genes and/or epigenetic factors determine the phenotype.

  20. Study on migration behavior of alkali metals during co-gasification of corn stalk and PE%玉米秸秆与塑料PE共气化过程中碱金属迁移行为的研究

    Institute of Scientific and Technical Information of China (English)

    杨天华; 肖蕾; 开兴平; 丁一; 陈志敏; 李润东

    2013-01-01

    The migration behavior of alkali metals during co-gasification of cornstalk and PE in a fixed bed at different temperatures was studied on the thermodynamic equilibrium calculation,the X-ray power diffraction and scanning electron microscope/energy dispersive spectrometer.The results indicat that the alkali chlorides (KCl、K2Cl2 、NaCl)are the main components in gaseous.There is a large amounts of C and H in the fules with the mixed of plastic PE.The H makes the C1 prefer HC1 to KC1,meanwhile,the release radio of K is lower than the cornstalk gasification cause of the C easily reacted with K than Na.Alkali metal compounds in ashes are mainly in the forms of KCl,NaCl,K2SO4,KAlSi3O8,KAlSiO4,NaAlSi3O8,NaAlSiO4.The KCl,NaC1 begin to release when the reacting temperature above 800 ℃ and most of K,Na,Cl are easily deposited on the edge of the hole.%选取一定混合比例的玉米秸秆与塑料PE制成混合燃料,采用固定床实验台,通过改变反应温度,并结合化学热力学平衡分析、X射线衍射及扫描电子显微电镜能谱分析技术对共气化过程中碱金属的迁移行为进行研究.结果表明,气化气中碱金属以气态组元KCl、K2Cl2、NaCl形式存在.混合燃料中掺入塑料PE后,C、H含量增加,H使得共气化反应中更容易与Cl反应生成HCl,而非KCl,同时C更容易与K结合,导致K的释放率低于单独玉米秸秆气化,但使Na释放率增加.灰中碱金属化合物以KCl、NaCl、K2SO4、KAlSi3O8、KAlSiO4、NaAlSi3O8、NaAlSiO4为主,气化温度高于800℃后灰中K、Na、Cl更易沉积于微孔边缘.

  1. Strategy as Story: Judgment, Bias, and the Narrative Behind the Decision to Invade Iraq

    Science.gov (United States)

    2011-05-06

    Dldul:e of such uso and Che Jikcly U.S.EillpOOIIO. MaugeJB!jt Qflt’!D Ia erl!kal tg 8iiSiiYJ liM\\ iS(~ • "’OO’Irm’• and-A.merbafsm could be edamed...34 Managing the International System Over the Next Ten Years: Three Essays. (New York: Trilateral Commission, July 1997): 43-62 Woodward, Bob. Plan...paradigms." (Kindle LOC 739) v Paul Wolfowitz. "Managing Our Way to a Peaceful Century." Managing the International System Over the Next Ten Years: Three

  2. European League Against Rheumatism recommendations for terminology and diagnosis of calcium pyrophosphate crystal deposition disease: An expert's comments

    Directory of Open Access Journals (Sweden)

    Viktoriya Georgievna Barskova

    2011-09-01

    Full Text Available V etoy stat'e my provodim obsuzhdenie 9 rekomendatsiy, kotorye razrabotany standartnym metodom sochetaniya dokazatel'nykh issledovaniy i konsensusa ekspertov. V svyazi s bol'shim spektrom klinicheskikh fenotipov deponirovaniya kristallov pirofosfata kal'tsiya (PFK terapiya bolezni predstavlyaet slozhnuyu zadachu, tem bolee chto, v otlichie ot podagry, v nastoyashchee vremya net spetsificheskoy terapii, sposobstvuyushchey ischeznoveniyu PFK. Poetomu lechenie sfokusirovano na kontrole klinicheskikh simptomov kak ostrogo, tak i khronicheskogo artrita. Ispol'zuyutsya podkhody, analogichnye takovym pri terapii ostrogo podagricheskogo artrita, kontrole boli i simptomov pri osteoartroze (OA.

  3. European League Against Rheumatism recommendations for terminology and diagnosis of calcium pyrophosphate crystal deposition disease: An expert's comments

    Directory of Open Access Journals (Sweden)

    Viktoriya Georgievna Barskova

    2011-01-01

    Full Text Available V etoy stat'e my provodim obsuzhdenie 9 rekomendatsiy, kotorye razrabotany standartnym metodom sochetaniya dokazatel'nykh issledovaniy i konsensusa ekspertov. V svyazi s bol'shim spektrom klinicheskikh fenotipov deponirovaniya kristallov pirofosfata kal'tsiya (PFK terapiya bolezni predstavlyaet slozhnuyu zadachu, tem bolee chto, v otlichie ot podagry, v nastoyashchee vremya net spetsificheskoy terapii, sposobstvuyushchey ischeznoveniyu PFK. Poetomu lechenie sfokusirovano na kontrole klinicheskikh simptomov kak ostrogo, tak i khronicheskogo artrita. Ispol'zuyutsya podkhody, analogichnye takovym pri terapii ostrogo podagricheskogo artrita, kontrole boli i simptomov pri osteoartroze (OA.

  4. Wirkung von Starter- und Schutzkulturen sowie ihrer Metabolite auf die Infektiosität von murinem Norovirus S 99 und Influenzavirus H1N1 in kurzgereiften Rohwürsten

    OpenAIRE

    2014-01-01

    Viren haben als Ursache lebensmittelassoziierter Infektionen eine große Bedeutung. Sie können vor allem über rohe oder unzureichend erhitzte Lebensmittel übertragen werden. In diesem Zusammenhang werden grüner Salat, Erdbeeren, Himbeeren, Frühlingszwiebeln, Muscheln, halbgetrocknete Tomaten, fäkal verunreinigtes Trinkwasser, Backwaren und Rohwürste als häufige Infektionsquellen genannt. Vor allem kurzgereifte Rohwürste gehören aus mikrobiologischer Sicht zu Risikoprodukten. Um eine gleichblei...

  5. Croatian Traditional Herbal Dyes For Textile Dyeing

    OpenAIRE

    Sutrlović, Ana

    2011-01-01

    Textiles, namely protein fibers, in continental part of central Europe have been traditionally dyed by natural dyes. In the process textile materials were pre or after treated by metal salts – mordants (usually: KAl(SO4)2•12H2O, SnCl2•2H2O, FeSO4•7H2O, CuSO4•5H2O). Most represented active substances in herbal extracts are flavonoid derivatives, which by complexing with metal ions constitute colored complexes. Depending on herb species and mordant applied, a wide palette of colors is available...

  6. Effect of alum on free-living and copepod-associated Vibrio cholerae O1 and O139.

    OpenAIRE

    Chowdhury, M A; Huq, A.; Xu, B.; Madeira, F J; Colwell, R R

    1997-01-01

    The effects of alum [KAl(SO4)2] on free-living and copepod-associated Vibrio cholerae O1 and O139 were investigated by using plate counts and immunofluorescence direct viable counting (DVC). Growth of alum-treated cells in 0.5/1000 Instant Ocean seawater was inhibited, i.e., no growth was obtained on Luria-Bertani (LB) agar or thiosulfate-citrate-bile salt-sucrose (TCBS) agar. However, a significant number of the inhibited cells maintained viability, as measured by DVC. In comparison, a signi...

  7. Molecular strategies to engineer transgenic rice seed compartments for large-scale production of plant-made pharmaceuticals.

    Science.gov (United States)

    Greenham, Trevor; Altosaar, Illimar

    2013-01-01

    The use of plants as bioreactors for the large-scale production of recombinant proteins has emerged as an exciting area of research. The current shortages in protein therapeutics due to the capacity and economic bottlenecks faced with modern protein production platforms (microbial, yeast, mammalian) has driven considerable attention towards molecular pharming. Utilizing plants for the large-scale production of recombinant proteins is estimated to be 2-10% the cost of microbial platforms, and up to 1,000-fold more cost effective than mammalian platforms (Twyman et al. Trends Biotechnol 21:570-578, 2003; Sharma and Sharma, Biotechnol Adv 27:811-832, 2009). In order to achieve an economically feasible plant production host, protein expression and accumulation must be optimized. The seed, and more specifically the rice seed has emerged as an ideal candidate in molecular pharming due to its low protease activity, low water content, stable protein storage environment, relatively high biomass, and the molecular tools available for manipulation (Lau and Sun, Biotechnol Adv 27:1015-1022, 2009).

  8. Diagnosis and management of miliary tuberculosis: current state and future perspectives [Retraction

    Directory of Open Access Journals (Sweden)

    Ray S

    2015-09-01

    Full Text Available Ray S, Talukdar A, Kundu S, Khanra D, Sonthalia N. Ther Clin Risk Mngmt. 2013;9:9–26.The editor of the Indian Journal of Medical Research has brought to our attention the unacknowledged re-use of significant portions of text in the above article. The source of much of the text appears to be from:Sharma SK, Mohan A, Sharma A. Challenges in the diagnosis and treatment of miliary tuberculosis. Indian J Med Res. 135, May 2012, pp 703–730.Dr Ray comments thus: “Regarding the similarities found we want to clarify that this apparent plagiarism is not an intentional act and likely to be factual error. In any way, we do not want to undermine scientific pursuit or vitiate the investigational spirit of hard work and creativity. Please be informed that the different portions of the review were written by different co-authors and most of them were postgraduate students at that time. It seems that they have taken materials/ideas from previously published source unaware of the issues of plagiarism.” This retraction relates to this paper

  9. Knowledge regarding postexposure prophylaxis of HIV among nurses

    Directory of Open Access Journals (Sweden)

    Dhital PS

    2017-04-01

    Full Text Available Puja Sharma Dhital,1 Sarojini Sharma,2 Pratik Poudel,3 Pankaj Raj Dhital4 1Adult Health Nursing, Nepal Polytechnic Institute, College of Nursing, 2Adult Health Nursing, BP Koirala Memorial Cancer Hospital, 3Department of Radiology, College of Medical Sciences, Bharatpur, 4Department of Agricultural Extension and Rural Sociology, Agriculture and Forestry University, Rampur, Nepal Abstract: Fifty nurses working in BP Koirala Memorial Cancer Hospital, Bharatpur, were selected by probability simple random sampling technique for determining the knowledge level about postexposure prophylaxis (PEP of HIV among nurses during 2014. A descriptive design, semistructured self-administered questionnaire was used for the study. The study showed that 48% of respondents had knowledge on the meaning of PEP, only 39.39% respondents were aware of the first aid management getting needle prick injury, 60% were aware of the best time to start PEP of HIV and 56% respondents had knowledge about the time schedule of HIV test after exposure. Although the respondents answered most of the questions correctly, they had knowledge deficit in certain areas. The respondents’ knowledge in this regard needs to be improved with time-to-time awareness program and periodic training, which ultimately helps to decrease the transmission of disease and reduces mortality and morbidity. Keywords: needle prick injury, transmission, PEP, HIV 

  10. Estado actual de la investigación sobre la gestión del conocimiento en empresas familiares

    Directory of Open Access Journals (Sweden)

    Ketty Navarro de Granadillo

    2008-01-01

    Full Text Available En este artículo se expone el resultado de un trabajo de carácter exploratorio con dos objetivos: examinar el estado actual de la investigación sobre gestión del conocimiento en empresas familiares, con especial énfasis en aquellas experiencias relacionadas con la gestión del conocimiento y actualizar la clasificación de los estudios de empresas familiares propuesta por Sharma (2004. Representa la etapa inicial de una investigación mayor que tiene el propósito de estudiar a las empresas familiares españolas desde el enfoque de la gestión del conocimiento. Para los efectos se tomó como referencia el modelo de Sharma (2004 para la clasificación de los estudios sobre empresas familiares. Se realizó una búsqueda de publicaciones académicas registradas en las diversas bases de datosmultidisciplinarias y sobre negocios, disponibles desde la biblioteca de la Universidad Castilla la Mancha (UCLM España, en el área de empresa familiar. Los resultados encontrados, indican que a partir del año 2000 se incrementa considerablemente el número de publicaciones sobre las empresas familiares, no obstante, se observa la inexistencia de estudios sobre gestión del conocimiento en este tipo de empresa.

  11. Improved complexity bounds for real root isolation using Continued Fractions

    CERN Document Server

    Tsigaridas, Elias

    2010-01-01

    We consider the problem of isolating the real roots of a square-free polynomial with integer coefficients using (variants of) the continued fraction algorithm (CF). We introduce a novel way to compute a lower bound on the positive real roots of univariate polynomials. This allows us to derive a worst case bound of $\\sOB(d^6 + d^4\\tau^2 + d^3\\tau^2)$ for isolating the real roots of a polynomial with integer coefficients using the classic variant of CF, where $d$ is the degree of the polynomial and $\\tau$ the maximum bitsize of its coefficients. This improves the previous bound by Sharma \\cite{sharma-tcs-2008} by a factor of $d^3$ and matches the bound derived by Mehlhorn and Ray \\cite{mr-jsc-2009} for another variant of CF; it also matches the worst case bound of the subdivision-based solvers. We present a new variant of CF, we call it iCF, that isolates the real roots of a polynomial with integer coefficients in $\\sOB(d^5+d^4\\tau)$, thus improving the current known bound for the problem by a factor of $d$. If...

  12. Improved complexity bounds for real root isolation using Continued Fractions

    CERN Document Server

    Tsigaridas, Elias

    2010-01-01

    We consider the problem of isolating the real roots of a square-free polynomial with integer coefficients using (variants of) the continued fraction algorithm (CF). We introduce a novel way to compute a lower bound on the positive real roots of univariate polynomials. This allows us to derive a worst case bound of $\\sOB( d^6 + d^4\\tau^2 + d^3\\tau^2)$ for isolating the real roots of a polynomial with integer coefficients using the classic variant of CF, where $d$ is the degree of the polynomial and $\\tau$ the maximum bitsize of its coefficients. This improves the previous bound by Sharma \\cite{sharma-tcs-2008} by a factor of $d^3$ and matches the bound derived by Mehlhorn and Ray \\cite{mr-jsc-2009} for another variant of CF; it also matches the worst case bound of the subdivision-based solvers. We present a new variant of CF, we call it iCF, that isolates the real roots of a polynomial with integer coefficients in $\\sOB(d^5+d^4\\tau)$, thus improving the current known bound for the problem by a factor of $d$. I...

  13. Identification of Pathogen Species in the Fruit Rot of Mango Ivory Cultivar in Guangxi Province%广西杧果象牙品种果腐病病原菌种类鉴定

    Institute of Scientific and Technical Information of China (English)

    贺冰; 贺运春; 李志岗

    2012-01-01

    The pathogens isolated from the infected mango flesh of Ivory cultivar in Guangxi province, were identified as Col- letotrichum gloeosporioides (Penz.) Sacc. And Macrophoma mangiferae Hingoroai et Sharma. The fruit rot of Ivory mango caused commonly by Colletotrichum gloeosporioides and Macrophoma mangiferae, the symptoms between two pathogens showed similarity, however, symptoms of pathogens marked distinction. Disease spots of the mango fruit rot (Colletotrichum gloeosporioides ) had ring liked black points and protruding ochre particles; disease spots of the mango fruit rot (Macrophoma mangiferae ) had densely scattered small black dots and with no protruding particles.%广西杧果象牙品种发生的果腐病,经病原鉴定,其种类为杧果炭疽菌(Colletotrichum gloeosporioides (Penz.) Sacc.)和杧果大茎点菌(Macrophoma mangiferae Hingoroai et Sharma).这2种菌均可侵染杧果引起果腐病,其病状虽有相似性,但病症有明显差异.杧果炭疽菌果腐病病斑上生轮纹状小黑点,其顶端有黄褐色颗粒状物;杧果大茎点菌果腐病病斑生小黑点,小而密,其上无颗粒状物.

  14. A numerical simulation analysis of the effect of the interface drag function on cluster evolution in a CFB riser gas-solid flow

    Directory of Open Access Journals (Sweden)

    L. C. Gómez

    2004-12-01

    Full Text Available The dynamics of formation, dissipation and breaking of coherent structures in the riser gas-solid flow of a circulating fluidized bed (CFB are evaluated by numerical simulation. The simulation is performed using the MICEFLOW code, which includes IIT's two-fluid hydrodynamic model B. The methodology for cluster characterization is used from Sharma et al. and is based on determination of four characteristics, average lifetime, average volumetric fraction of solid, existence time fraction and frequency of occurrence. Clusters are identified applying a criterion for the time average value of the volumetric solid fraction. A qualitative analysis of the influence of different drag function correlations on the hydrodynamics of the flow, including the evolution of coherent structures, is performed. The simulation predictions are also compared to experimental results. The results indicate that the choice of a correlation for drag function should be quite judicious. Finally it is shown that the mean clustering criteria of Sharma et al. should be modified to take into account other factors that influence cluster dynamics.

  15. Review - The Sherthukpens of Arunachal Pradesh

    Directory of Open Access Journals (Sweden)

    Christopher Weedall

    2013-12-01

    Full Text Available Review of: Anita Sharma. 2013. The Sherthukpens of Arunachal Pradesh: A Narrative of Cultural Heritage and Folklore. New Delhi: Indian National Trust for Art and Cultural Heritage and Aryan Books International. Scheduled tribes – indigenous people who are acknowledged to some formal extent by national legislation – of Arunachal Pradesh, formerly part of the North-East Frontier Association, in North-East India, have been largely neglected in terms of cultural and linguistic study, with a few exceptions, such as Elwin (1958, 1959, 1988, Das (1995, and Chowdhury (1973. This region, however, is home to a diverse group of individuals who have only recently been introduced to modernization. For this reason, until recently, most tribes in the area have retained traditions that were maintained for centuries or longer. Due to the contemporary influx of roads, electricity, and television, these traditions have been threatened and are gradually giving way to modern (largely Western ideas and practices. It is for this reason that Anita Sharma's The Sherthukpens of Arunachal Pradesh: A Narrative of Cultural Heritage and Folklore (henceforth Sherthukpens comes at an opportune time to investigate and record the heritage of the Sherthukpen people as it was and is now becoming. Sherthukpens is a hardbound book with a well-made, ...

  16. Numerical simulation of flow around square cylinder using different low-Reynolds number turbulence models

    Institute of Scientific and Technical Information of China (English)

    ZHANG Ling; ZHOU Jun-li; CHEN Xiao-chun; LAN Li; ZHANG Nan

    2008-01-01

    ABE-KONDOH-NAGANO, ABID, YANG-SHIH and LAUNDER-SHARMA low-Reynolds number turbulence models were applied to simulating unsteady turbulence flow around a square cylinder in different phases flow field and time-averaged unsteady flow field. Meanwhile, drag and lift coefficients of the four different low-Reynolds number turbulence models were analyzed. The simulated results of YANG-SHIH model are close to the large eddy simulation results and experimental results, and they are significantly better than those of ABE-KONDOH-NAGANO, ABID and LAUNDER-SHARMR models. The modification of the generation of turbulence kinetic energy is the key factor to a successful simulation for YANG-SHIH model, while the correction of the turbulence near the wall has minor influence on the simulation results. For ABE-KONDOH-NAGANO, ABID and LAUNDER-SHARMA models satisfactory simulation results cannot be obtained due to lack of the modification of the generation of turbulence kinetic energy. With the joint force of wall function and the turbulence models with the adoption of corrected swirl stream,flow around a square cylinder can be fully simulated with less grids by the near-wall.

  17. BALİSTİK ÇARPMA ETKİSİNİN SONLU ELEMANLAR YÖNTEMİYLE İNCELENMESİ

    OpenAIRE

    2013-01-01

    Bu çalışmada yüksek hızlı darbeye maruz Titanyum, TI 6%AL4%V ve Çelik 4340 levhalarının artan levha kalınlığı ve değişen vurucu geometrisine bağlı olarak dinamik cevabı sonlu elemanlar yöntemi kullanılarak araştırılmıştır. Darbe uygulanacak levhalar 200×200 mm ebatlarında ve 1 mm, 2 mm, 3 mm, 4 mm, 5 mm, 6 mm ve 7 mm kalınlık değerlerine sahip olacak şekilde modellenmiştir. Vurucu malzemesi olarak Çelik 4340 seçilmiş olup bütün analizler 350 m/s’lik çarpma hızlarında gerçekleştirilmiştir. Kul...

  18. TOPLU KONUT ÜRETİMİNDE TÜNEL KALIP SİSTEMİ UYGULAMALARI VE KARŞILAŞILAN SORUNLAR

    OpenAIRE

    OĞUZALP, Ercan H.; KORUR, Saim

    2005-01-01

    Bu çalışma, her geçen gün daha da çok artan konut ihtiyacının karşılanmasında yaygın olarak kullanılan tünel kalıp sisteminin uygulama ve kullanımında karşılaşılan sorunlarla ilgilidir. Ülkemiz ve üretim adına kazandırdıklarının yanında üretici firmaların maliyeti düşünerek uygulayamadıkları detaylar sonucunda halen çözülemeyen sorunlarının bulunması sistem açısından dezavantaj oluşturmaktadır. Çalışmanın oluşmasında, endüstrileşmiş yapım teknikleri ve tünel kalıp üretim sistemiyle ilgili ola...

  19. BEBERAPA PILIHAN MAKANAN FORMULA LANJUTAN UNTUK ANAK USIA 1-3 TAHUN

    Directory of Open Access Journals (Sweden)

    Rossi R. Apriyantono

    2012-11-01

    Full Text Available Hasil penelitian terdahulu menunjukkan adanya khasiat makanan formula tempe (MFT dalam membantu penyembuhan diare kronik pada penderita gizi kurang dan gizi buruk, disamping dapat menaikkan berat badan, kadar hemoglobin dan status immunitas. Laporan pelaksanaan pemberian MFT pada anak KEP, diketahui bahwa setelah tercapai berat badan normal anak satu tahun maka percepatan kenaikannya melambat. Suatu makanan formula lanjutan yang sesuai untuk anak usia 1-3 tahun akan sangat membantu perkembangan berat badan selanjutnya, sehingga diharapkan tidak akan terjadi hambatan pertumbuhan. Penelitian ini bertujuan untuk memformulasikan makanan campuran yang siap hidang yang memenuhi syarat makanan untuk anak usia 1-3 tahun dari segi gizi, cita rasa dan tampilan fisiknya. Dari hasil penghitungan dan formulasi diperoleh 7 formula yang sesuai dengan persyaratan Codex Alimentarius Commission. Setelah dianalisis kandungan zat gizi makro, kadar karotin, mutu organoleptik dan tampilan fisiknya, maka terpilih 3 formula terbaik yaitu campuran tempe + terigu + susu skim + pisang ambon; tempe + terigu + susu skim + pisang ambon + wortel dan tempe + tepung beras + susu skim + wortel. Dalam 100 g ketiga formula ini mengandung energi sebesar 423±13 kal, protein 18±1.2 g, lemak 11.1±2.7 g, karotin 1393±1140 ug, dengan nilai NDpKal sebesar 7.8±0.1. Untuk pengembangan selanjutnya akan dipikirkan kemungkinan penambahan sumber asam lemak n-3 dan bahan pemantap dari jenis gum, sehingga formula yang dihasilkan akan lebih mempunyai nilai tambah.

  20. HİRSUTİSM TEDAVİSİNDE YÜKSEK FREKANSLI ALTERNATiF • • AKIMLARININ KULLANIMI VE YENI BIR METOD : COOL-FLASH

    Directory of Open Access Journals (Sweden)

    ALİ ÖZGÜÇ GÖKSU

    2003-12-01

    Full Text Available Hirsutism (Aşırı kıllanma; yüz, göğüs, karın, sırt, kol ve hacakları n üst kısmında uzun, kalın ve sert kılların çıknıasıdır. Bu duruınun temel sebebi erkeklik hormonunun çeşitli nedenlerle artmasıdır. Günümüzde bu hastalığın kalıcı tedavisi için kullanılmakta olan en güvenilir ve etkili metot, Elektro-Epilasyoo ile kılların yok edilmesidir. Kıl foliküllerinin doğru şekilde imha edilmesinde foliküle verilen akımın özellikleri ve uygulanıa şekli çok önemlidir. İşte bu noktada geliştirmiş olduğumuz yeni metodun avantajları ile karşılaşmaktayız: Uygulama esnasında hastanın hissettiği acıda azalma ve uygulama paramet relerinin cihaz tarafından belirlenmesi sonucu en doğru ve verimli tedavi.

  1. Asthma caused by potassium aluminium tetrafluoride: a case series.

    Science.gov (United States)

    Laštovková, Andrea; Klusáčková, Pavlina; Fenclová, Zdenka; Bonneterre, Vincent; Pelclová, Daniela

    2015-01-01

    The objective of this study is to describe a case-series of potassium aluminium tetrafluoride (KAlF(4))-induced occupational asthma (OA) and/or occupational rhinitis (OR). The study involves five patients from a heat-exchanger production line who were examined (including specific inhalation challenge tests) for suspected OA and/or OR caused by a flux containing almost 100% KAlF(4) - with fluorides' workplace air concentrations ranging between 1.7 and 2.8 mg/m(3). No subject had a previous history of asthma. All five patients had a positive specific challenge test (three patients were diagnosed with OA alone, one with OR and one with both OR and OA). At the follow-up visit, after three years on average, all patients needed permanent corticosteroid therapy (four topical, one oral). After elimination from the exposure, only one of the observed subjects gave an indication of an improvement, two subjects stabilized and two worsened. Our case series focuses on the correlation between patients' exposure to fluorides in air-conditioner production and the subsequent occurrence of OR/OA. Currently, it is uncertain whether these OR/OA were caused by hypersensitivity or irritation.

  2. Long-range restriction map of the terminal part of the short arm of the human X chromosome

    Energy Technology Data Exchange (ETDEWEB)

    Petit, C.; Levilliers, J.; Weissenbach, J. (Institut Pasteur, Paris (France))

    1990-05-01

    The terminal part of the short arm of the human X chromosome has been mapped by pulsed-field gel electrophoresis (PFGE). The map, representing the distal two-thirds of Xp22.3 spans a total of 10,000 kilobases (kb) from Xpter to the DXS143 locus. A comparison with linkage data indicates that 1 centimorgan (cM) in this region corresponds to about 600 kb. CpG islands were essentially concentrated in the 1,500 kb immediately proximal to the pseudoautosomal boundary. Several loci, including the gene encoding steroid sulfatase (STS) and the loci for the X-linked recessive form of chondrodysplasia punctata (CDPX) and for Kallmann syndrome (KAL) have been placed relative to the Xp telomere. CDPX is located between 2,650 and 5,550 kb from Xpter, and STS is located between 7,250 and 7,830 kb from Xpter. KAL maps to an interval of 350 kb between 8,600 and 8,950 kb from the telomere. The X-chromosomal breakpoints of a high proportion of XX males resulting from X-Y interchange cluster to a 920-kb region proximal and close to the pseudoautosomal boundary.

  3. Phase relationships in the area of the beta aluminate of the system K{sub 2}O-MgO-AL{sub 2}O{sub 3}; Phasenbeziehungen im Bereich der Beta-Aluminate des Systems K{sub 2}O-MgO-Al{sub 2}O{sub 3}

    Energy Technology Data Exchange (ETDEWEB)

    Kroon, P. de

    1996-12-01

    The aim of this work was to be able to make statements about the thermodynamic stability of K-{beta}``-Al{sub 2}O{sub 3} in the pseudo-binary system K{sub 2}O-Al{sub 2}O{sub 3} and in the pseudo-ternary system K{sub 2}O-MgO-Al{sub 2}O{sub 3} relative to the adjacent phases of KAlO{sub 2} {alpha}-Al{sub 2}O{sub 3}, MgAl{sub 2}O{sub 4} and K-{beta}-Al{sub 2}O{sub 3}. (orig./MM) [Deutsch] Ziel dieser Arbeit war es, Aussagen ueber die thermodynamische Stabilitaet von K-{beta}``-Al{sub 2}O{sub 3} im pseudobinaeren System K{sub 2}O-Al{sub 2}O{sub 3} und im pseudoternaeren System K{sub 2}O-MgO-Al{sub 2}O{sub 3} relativ zu den benachbarten Phasen KAlO{sub 2}, {alpha}-Al{sub 2}O{sub 3}, MgAl{sub 2}O{sub 4} und K-{beta}-Al{sub 2}O{sub 3} machen zu koennen. (orig./MM)

  4. 快速测定COD最佳催化消解体系研究%Study on the optimal catalytic system for rapiddetermination of COD

    Institute of Scientific and Technical Information of China (English)

    许健; 周春洪; 屠一锋

    2001-01-01

    通过正交试验,确定了测定环境水样中COD的最佳回流消解条件.以CuSO4作催化剂,Kal(SO4)2-Na2MoO4作助催化剂(0.18 g CuSO4·5H2O-0.10 g Kal(SO4)2·12H2O-0.10 g Na2MoO4·2H2O),在H2SO4-H3PO4体系中可很好地实现对样品的消解.该体系将回流时间由国标法的2 h缩短至20min,实现了快速测定的目的且大幅度降低测定成本.样品10次平行测定的相对标准偏差为1.1%;加标回收率为97.7%~103.3%,均与国标法无显著性差异.

  5. Su Ürünleri Yetiştiriciliğinde Büyüme Artırıcı Olarak Sarımsak (Allium sativum Kullanımı

    Directory of Open Access Journals (Sweden)

    Suat Dikel

    2015-07-01

    Full Text Available Antibiyotik ve medikamentlerin yaygın kullanımı sonucu balıklarda kimyasal kalıntılar ve dirençli patojenler ortaya çıkmaktadır. Kimyasal kalıntılar sadece çevre kirliliği yaratmamakta bununla birlikte tüketici sağlığını da tehdit etmektedir. Buna karşın doğal bir antibiyotik olarak bilinen sarımsak insan ve hayvanlarda birçok hastalığın tedavisinde etkilidir ve her hangi bir çevresel ya da fiziksel yan etkiye sahip değildir. Su ürünleri yetiştiriciliği uygulamalarında sarımsak, büyümeyi artırmakta, bağışıklık sistemini güçlendirmekte, iştahı artırmakta, mantar ve bakteriyel patojenlerin kontrolünü desteklemektedir. Bu derleme yetiştiricilikte sarımsak uygulamalarının balıklarda, beklenen büyüme artırıcı etkilerini ortaya koyma üzerine yoğunlaşmıştır.

  6. WEIGHTED LEAST SQUARE CONVERGENCE OF LAGRANGE INTERPOLATION ON THE UNIT CIRCLE

    Institute of Scientific and Technical Information of China (English)

    Xie Siqing

    2001-01-01

    In the paper, a result of Walsh and Sharma on least squareconvergence of Lagrange interpolation polynomials based on the n-th roots of unity is extended to Lagrange interpolation on the sets obtained by pro-jecting vertically the zeros of (1-x)2P.β (x),α>0,β>0, (1-x)p β (x),α>0,β>-1, (1+x)p ,(x) ,α>-1 ,β>0, and P (x ) ,α> - 1 ,β> - 1, respectively, onto the unit circle, where p ( ,β) (x ) ,α> - 1 , β> - 1, stands for the n-th Jacobi polynomial. Moreover, a result of Saff and Walsh is also extended.CLC Number:O17 Document ID:AFoundation Item:Project supported by NSFC under grant 10071039, and by Education Committee of Jiangsu Province under grant 00KJB110005.References:[1]Walsh,J.L. and Sharma,A.,Least Square Approximation and Interpolation in Roots of Unity,Pacific J. Math. ,14(1964),727-730.[2]Erdos,P. and Turán,P. ,On Interpolation I ,Ann. Math. ,38(1937),142-155.[3]Lozinsi,S.M.,Uber Interpolation (in Russian),Math. Sbornik (N.S.),8(1940),57-68.[4]Saff,E.B. and Walsh,J.L. ,On the Convergence of Rational Functions which Interpolate in the Roots of Unity,Pacific J. Math. 45(1973),639-641.[5]Sharma,A. and Vertesi,P. ,Mean Convergence and Interpolation in Roots of Unity,SIAM J.Math. Anal. ,14(1983),800-806.[6]Natason,I.P. ,Constructive Theory of Functions,Gostekhizdat,Moscow,1949.[7]Szego,G. ,Orthogoral Polynomials,Math. Soc. Colloq. Publ. ,Vol.[2]3 4th ed. Math. Soc. ,Providence,RI. ,1975.Manuscript Received:1999年9月13日Manuscript Revised:2001年5月8日Published:2001年9月1日

  7. SDCLIREF - A sub-daily gridded reference dataset

    Science.gov (United States)

    Wood, Raul R.; Willkofer, Florian; Schmid, Franz-Josef; Trentini, Fabian; Komischke, Holger; Ludwig, Ralf

    2017-04-01

    Climate change is expected to impact the intensity and frequency of hydrometeorological extreme events. In order to adequately capture and analyze extreme rainfall events, in particular when assessing flood and flash flood situations, data is required at high spatial and sub-daily resolution which is often not available in sufficient density and over extended time periods. The ClimEx project (Climate Change and Hydrological Extreme Events) addresses the alteration of hydrological extreme events under climate change conditions. In order to differentiate between a clear climate change signal and the limits of natural variability, unique Single-Model Regional Climate Model Ensembles (CRCM5 driven by CanESM2, RCP8.5) were created for a European and North-American domain, each comprising 50 members of 150 years (1951-2100). In combination with the CORDEX-Database, this newly created ClimEx-Ensemble is a one-of-a-kind model dataset to analyze changes of sub-daily extreme events. For the purpose of bias-correcting the regional climate model ensembles as well as for the baseline calibration and validation of hydrological catchment models, a new sub-daily (3h) high-resolution (500m) gridded reference dataset (SDCLIREF) was created for a domain covering the Upper Danube and Main watersheds ( 100.000km2). As the sub-daily observations lack a continuous time series for the reference period 1980-2010, the need for a suitable method to bridge the gap of the discontinuous time series arouse. The Method of Fragments (Sharma and Srikanthan (2006); Westra et al. (2012)) was applied to transform daily observations to sub-daily rainfall events to extend the time series and densify the station network. Prior to applying the Method of Fragments and creating the gridded dataset using rigorous interpolation routines, data collection of observations, operated by several institutions in three countries (Germany, Austria, Switzerland), and the subsequent quality control of the observations

  8. Reviewer Database

    Directory of Open Access Journals (Sweden)

    Chief Editor

    2016-06-01

    Full Text Available REVIEWER DATABASEA S PaddaAarati KrishnanAarti KapilAbdul JilaniAbhaya JoglekarAbhijit PakhareAbhisek MishraAbhishek ArunAbhishek GuptaAbhishek JadhavAbhishek SinghAditi SinghAdrija RoyAdwitiya MukhopadhyayAhmed MandilA SubramanianAjit SahaiAkanksha GautamAkela MohamedAkhila GopinathanAkshay KumarAlankrata JainAli AbediAlisha SyiemliehAmal BasuAmandeep KaurA ChauhanAmarnath GuptaAmar SinhaAmir M KhanAmit KaushikAmit PawaiyaAmit SinghAmrita KansalAmrita SougaijamA WadheraAnand DixtA NeelakantanAnil PurtyAnimesh JainAnisha MohanAnjali AroraAnjan DattaAnju GahlotAnkita BajpaiAnku SaikiaAnmol GoyalAnu AgrawalAnu BhardwajAnuj JangraAnupama AryaA MohokarAnurag ChaudaryA SrivastavaAr BondArnab GhoshArpan YagnikArpit PrajapatiArshad AyubArti RauthanArun SainiArun SharmaArun ShiraliArun SugumaranArun VargheseArun WanjpeArvind NathArvind SinghAsha RAshish ChauhanAshish SinhaAshish SrivastavaAshish YadavAshok BhardwajAshok SrivastavaAshu GroverAshutosh SarwaAshwani SinhaAshwini KumarAthar AnsariAtul PuthiaAustin OkpanmaAvijit DasAvijit SinghaAvinash SunthliaB P MathurB VermaBabu DilipBadri MisraBaridalyne NongkynrihBhaswati SenguptaBhavana PandeyBhavana PantBhola NathBhupinder AnandBhupinder SinghBhuwan SharmaBiju SomanBimlesh KumarBinod KumarBinod PatroBishwas AcharyaBiswajit PaulB ChakravarthyB MannaC M S RawatC P MishraC M SinghChandra PrabhaChibi RushithaChitrangada MistryD SrivastavaDaksh SharmaDaneshwar SinghDanish ImtiazDebabrata RoyDeep ShikhaDeepa NairDeepak ChopraDeepak GuptaDeepak SharmaDeepika MittalNandanwarD SharmaDevi NairDharma BhattaD GahwaiDheeraj SharmaDhiraj SrivastavaDhrubajyotiDileepanDinesh BhatnagarDipanjan DeyDivya RajaseharanEkta GuptaEmanuel CummingsEnakshi GanguliFabrice JotterandFatma KarasuFomboh RichardGagan GargGajendra GuptaGarima MittalG BandyopadhyayGeetanjali KapoorGeetu SinghGhos AhmedGirish ChavanGirjesh YadavGita NegiGmsubba RaoGnanakshiGobezie TemesgenGokul ShindeGouri PadhyKassa GideboGunjan NathH ChopraHameeda Ali

  9. A COMPARATIVE STUDY ON COMPOUND NOUN AND SEMI-COMPOUND NOUN IN TURKEY TURKISH TÜRKİYE TÜRKÇESİNDE BİRLEŞİK İSİM VE YARI-BİRLEŞİK İSİM ÜZERİNE KARŞILAŞTIRMALI BİR İNCELEME

    Directory of Open Access Journals (Sweden)

    Ahmet AKÇATAŞ

    2010-07-01

    Full Text Available Compound nouns are nouns that are formed by two different words that come together by coalescing and taking a fixed form, gaining another meaning from their own. In this study, the semi-compound noun term is proposed for the phrases that are not fixed. After that, the semi-compound nouns are examined in terms of their structure. Then, how phrases establish the semi-compound nouns, passing to word level than phrases level, only by nominalisation, without having a fixed form is determined. After these examinations and identifications, the suffixes and postpositions that the semi-compound nouns have are emphasized. In the conclusion, by adding semi-compound nouns to the classification such as simple, derived and compound nouns a deficiency term and issue is put forward (simple noun, derived noun; compound noun, semi-compound noun. Birleşik isimler, iki farklı sözcüğün bir araya gelerek kendi anlamlarından farklı bir anlam oluşturacak biçimde kaynaşıp kalıplaşmasıyla oluşan isimlerdir. Bu çalışmada birleşik isim dışında kalan, kalıplaşmamış öbek yapıdaki isimler için yarı-birleşik isim terimi önerilmiştir. Daha sonra yarı-birleşik isimler, yapıları bakımından incelenmiş. Sözcük öbeklerinin, öbek düzleminden sözcük düzlemine geçerken, kalıplaşmadan, sadece isimleşerek yarı-birleşik isimleri nasıl kurduğu belirlenmiştir. Bu inceleme ve belirlemelerden sonra yarı-birleşik isimlerin aldıkları ek ve edatlar üzerinde durulmuştur. Sonuçta basit, türemiş ve birleşik isimler şeklindeki sınıflamaya yarı-birleşik isimler de eklenerek eksik kalmış bir terim ve konu ortaya konulmuştur (basit isim, türemiş isim; birleşik isim, yarı-birleşik isim.

  10. Yapay Eskitmenin Bazı Odun Esaslı Levhaların Fiziksel Özelliklerine Etkisi

    Directory of Open Access Journals (Sweden)

    A. ALİ VAR

    2009-04-01

    Full Text Available Bu çalışmada yapay eskitmenin, yönlendirilmiş yongalılevha (OSB, yatık yongalılevha (PTB ve orta yoğunlukta liflilevha (MDF'nın bazı fizikî özelliklerine etkisinin araştırılması amaçlanmıştır. Bu maksatla, piyasadan temin edilen odun esaslı bu üç levha, ASTM D-1037'e göre 6 turlu eskitme işlemine maruz bırakılmıştır. Levhaların kalınlıkları, ağırlıkları, yoğunlukları ve rutubetleri eskitmeden önce ve sonra tayin edilmiştir. Elde edilen bulgular, bilgisayarda SPSS istatistik programı kullanılarak tahlil edilmiştir. Sonuç olarak; her levha türü için, bütün deney parçaları yapay eskitmenin birinci turundaki ikinci kurutmanın sonunda dağılmıştır. Bu nedenle kalan 5 tura devam edilememiştir. OSB, en az kütle ve rutubet kayıbına uğramıştır. En yüksek kalınlık artışı ve yoğunluk kayıbı MDF'de gerçekleşmiştir. Rutubet kayıbı yüzdesi MDF ve PTB'de hemen hemen aynı oranda kalmıştır. Yapay eskitmede, levha türünün kalınlık artışı, kütle, yoğunluk ve rutubet kayıpları üzerine etkisi 0.01 düzeyinde önemli bulunmuştur.

  11. 典型蓄电池的建模与荷电状态估算的对比研究%Comparison study on model and state of charge estimation of typical battery

    Institute of Scientific and Technical Information of China (English)

    吴红斌; 顾缃; 赵波; 朱承治

    2014-01-01

    研究不同蓄电池荷电状态(state of charge, SOC)的变化特征有助于在实际应用过程中对蓄电池类型进行选择。基于铅酸电池、磷酸铁锂电池、全钒液流电池3种典型蓄电池模型,采用电池容量修正过的改进安时计量法和改进安时-卡尔曼预测法( Ah-Kal法),对各电池在不同充放电模式下,用MATLAB软件编程得到两种估算方法下的SOC变化曲线。通过SOC对比曲线可以发现铅酸电池的自放电较严重,循环寿命短;磷酸铁锂电池可迅速提供大功率;而全钒液流电池适合作为长期大容量储能支持。同时,改进安时计量法和Ah-Kal的估算结果基本相同,验证了Ah-Kal法的正确性。%It is helpful to make the reasonable choice on types of battery in actual application through studying on state of charge (SOC) of the different batteries.Based on the models of Lead-acid battery, LiFePO4Li-ion battery and Vanadium Redox Flow battery(VRB), the SOC of each battery was estimated through the improved Ah count-ing method and the method of combined improved Ah counting-Kalman filtering(Ah-kal method).Under the differ-ent charging or discharging modes, it obtained the curves of SOC with MATLAB software.It can be found that the Lead-acid battery has the serious self-discharge and short cycle life, the LiFePO4Li-ion battery could supply rapidly high power, and VRB has the large-capacity energy storage support for long-term.With the simulation results, it validates that the improved Ah counting method and Ah-Kal method have almost equal result .And it verifies the correctness of the Ah-Kal method.

  12. West Nile virus infection and diplopia: a case report and review of literature

    Directory of Open Access Journals (Sweden)

    Dahal U

    2013-05-01

    Full Text Available Udip Dahal,1 Neville Mobarakai,1 Dikshya Sharma,2 Bandana Pathak11Department of Medicine, Staten Island University Hospital, Staten Island, New York, NY, USA; 2Department of Medicine, Nepalgunj Medical College, Banke, NepalAbstract: West Nile virus is a neurotropic virus transmitted to humans via an infected mosquito bite. The increase in the incidences and fatalities of West Nile virus disease has made West Nile virus an important pathogen. Here we describe a case of a 65-year-old man with fever and diplopia presenting to the emergency department during a fall season and who was later diagnosed with West Nile virus infection. Diplopia is an uncommon manifestation of West Nile virus and recognition of the different modes of presentation, especially the uncommon ones like diplopia, will aid in the diagnosis of this emerging infectious disease.Keywords: West Nile virus, diplopia, ocular manifestations, infectious disease, Flaviviridae

  13. Ritual, Performance, and Transmission: The Gaddi Shepherds of Himachal Himalayas

    Directory of Open Access Journals (Sweden)

    Mahesh Sharma

    2015-10-01

    Full Text Available Nawala, a sacrificial ritual offering made to Shiva, is central to the identity of the Gaddis, nomadic mountain shepherds of Himachal Pradesh in Northern India. Over a long period of time the Gaddis were encouraged to abandon shepherding and settle on the plains among agricultural communities. Displaced from their ancestral habitat and nomadic ways, the focus of their ritual performances changed. Examining one ritual text as a prism for folklore and social change, Sharma analyzes how dislocated “identity” negotiates and reinvents itself through ritual performance. The transformation of ritual text, disappearing lineages of traditional singers and ritual specialists, new interpretations and transmission agencies, as well as the eventual preservation and transmission of ritual-lore through audio and video technology, chart the trajectory of identity transformation and engagement with modernity.

  14. Influence of mycorhization and soil organic matters on lead and antimony transfers to vegetables cultivated in urban gardens: environmental and sanitary consequences

    Science.gov (United States)

    Pierart, Antoine; Braud, Armelle; Lebeau, Thierry; Séjalon-Delmas, Nathalie; Dumat, Camille

    2014-05-01

    The European Environment Agency estimates that c.a. 250 000 sites required clean up and that about 100 000 ha could have been contaminated by metals in Europe. Numerous remediation techniques have been therefore tested and phytoremediation appears as a sustainable and low cost in situ technique particularly for large-scale remediation of polluted arable soils. Arbuscular Mycorrhizal Fungi (AMF) are already used in phytoextraction or phytostabilisation of many metal(loid)s (GU ET AL., 2013, SHARMA AND SHARMA, 2013). However, while plant inoculation with AMF will mostly result of an increase of the plant biomass, the response for lead accumulation in shoots is contrasted (LEBEAU ET AL., 2008). Furthermore, nothing is actually known for Sb transfer to plants phytoremediation-assisted AMF. Yet recently, many researches concern the accumulation of Sb in the environment, its (eco)toxicity and the risk of bioaccumulation in vegetables (FENG ET AL., 2013), especially in some China areas where Sb mining activities have widely contaminated arable lands (WU ET AL., 2011). Our research project, which is part of a national program for urban gardens (JASSUR, http://www.agence-nationale-recherche.fr), focused on polluted soils in associative urban gardens with both geogenic and anthropogenic origins for Pb and Sb. The impact of Pb and Sb on AMF density and diversity was studied using morphological and biomolecular approaches. The role of AMF symbiosis with Lettuce (Lactuca sativa L.) on Pb and Sb compartmentalization, speciation and phytoavailability was investigated. The influence of soil organic matters on these processes was examined. Eventually, the part of metal(loid)s available for humans in case of ingestion of lettuces unfit for human consumption (FOUCAULT ET AL., 2013; XIONG ET AL., 2013) will be assessed in relation with the influence of AMF symbiosis and organic matter. Key Words: Mycorrhiza, Antimony, Compartmentation, Speciation, Edible Plants, Urban Agriculture

  15. Using standard CETSCALE and other adapted versions of the scale for measuring consumers’ ethnocentric tendencies: An analysis of dimensionality

    Directory of Open Access Journals (Sweden)

    José Felipe Jiménez-Guerrero

    2014-07-01

    Full Text Available The consumer ethnocentrism tendencies scale (CETSCALE was developed by Shimp and Sharma in 1987 to measure consumer ethnocentrism. It is one of the most commonly used scales in the marketing literature. As well as the original 17-item version, there are many empirical applications using other adapted versions of CETSCALE. These versions differ in terms of the number (and composition of items, incorporating additional items and even accounting for the nationality of the foreign products under study. Some of these papers question the unidimensionality of such a scale. We intend to analyse the dimensionality of the CETSCALE. In order to do this, an extensive review of previous studies that have considered CETSCALE—whatever the version—is developed. In addition, we analyse the dimensionality of an adapted version of the CETSCALE including the product category (vegetables under study. Our results support the multidimensionality of the CETSCALE.

  16. Review of the theoretical and empirical literature of consumer ethnocentrism

    Directory of Open Access Journals (Sweden)

    Stamule Stere

    2015-08-01

    Full Text Available This article presents an analysis of the concept of consumer ethnocentrism measured by the researchers with the use of the Consumer Ethnocentric Tendencies Scale (CETSCALE developed by Shimp and Sharma in 1987. The communication campaigns promoting the consumption of goods produced in Romania were revised together with the European legislation regarding this type of campaigns. While country-of-origin and ethnocentrism have been extensively researched, the link between CE and the attitude toward locally made products, as well as the link between CE and the attitude toward a buy local campaign has not been fully explored. The results will be useful for marketers, policy makers and businessmen to find what is especially important in consuming local products in Romania, why consumer ethnocentrism is relevant and what is influenced by consumer ethnocentrism. Such information could help them in taking strategically decisions.

  17. Dynamical passage to approximate equilibrium shapes for spinning, gravitating rubble asteroids

    Science.gov (United States)

    Sharma, Ishan; Jenkins, James T.; Burns, Joseph A.

    2009-03-01

    Many asteroids are thought to be particle aggregates held together principally by self-gravity. Here we study — for static and dynamical situations — the equilibrium shapes of spinning asteroids that are permitted for rubble piles. As in the case of spinning fluid masses, not all shapes are compatible with a granular rheology. We take the asteroid to always be an ellipsoid with an interior modeled as a rigid-plastic, cohesion-less material with a Drucker-Prager yield criterion. Using an approximate volume-averaged procedure, based on the classical method of moments, we investigate the dynamical process by which such objects may achieve equilibrium. We first collapse our dynamical approach to its statical limit to derive regions in spin-shape parameter space that allow equilibrium solutions to exist. At present, only a graphical illustration of these solutions for a prolate ellipsoid following the Drucker-Prager failure law is available [Sharma, I., Jenkins, J.T., Burns, J.A., 2005a. Bull. Am. Astron. Soc. 37, 643; Sharma, I., Jenkins, J.T., Burns, J.A., 2005b. Equilibrium shapes of ellipsoidal soil asteroids. In: García-Rojo, R., Hermann, H.J., McNamara, S. (Eds.), Proceedings of the 5th International Conference on Micromechanics of Granular Media, vol. 1. A.A. Balkema, UK; Holsapple, K.A., 2007. Icarus 187, 500-509]. Here, we obtain the equilibrium landscapes for general triaxial ellipsoids, as well as provide the requisite governing formulae. In addition, we demonstrate that it may be possible to better interpret the results of Richardson et al. [Richardson, D.C., Elankumaran, P., Sanderson, R.E., 2005. Icarus 173, 349-361] within the context of a Drucker-Prager material. The graphical result for prolate ellipsoids in the static limit is the same as those of Holsapple [Holsapple, K.A., 2007. Icarus 187, 500-509] because, when worked out, his final equations will match ours. This is because, though the formalisms to reach these expressions differ, in statics

  18. Crouzon’s Syndrome: A Rare Genetic Disorder

    Science.gov (United States)

    Bhatia, Hindpal; Sharma, Naresh

    2016-01-01

    Crouzon’s syndrome, also known as brachial arch syndrome, is an autosomal dominant disorder with complete penetrance and variable expressivity. Described by a French neurosurgeon in 1912, it is a rare genetic disorder. Crouzon’s syndrome is caused by mutation in the fibroblast growth factor receptor 2 (FGFR2) gene. Normally, the sutures in the human skull fuse after the complete growth of the brain, but if any of these sutures close early, then it may interfere with the growth of the brain. The disease is characterized by craniosynostosis, with associated dentofacial anomalies. This report describes the different clinical features in a 10-year-old male patient, with particular reference to characteristic findings of this syndrome. How to cite this article Kaushik A, Bhatia H, Sharma N. Crouzon’s Syndrome: A Rare Genetic Disorder. Int J Clin Pediatr Dent 2016;9(4):384-387. PMID:28127173

  19. Tribology of nanocomposites

    Energy Technology Data Exchange (ETDEWEB)

    Davim, J. Paulo (ed.) [Aveiro Univ. (Portugal). Dept. of Mechanical Engineering

    2013-02-01

    This book provides a comprehensive review of the latest developments in nanotribology. It contains the following five chapters: 1. Tribology of bulk polymer nanocomposites and nanocomposite coatings (M. D. Bermudez, F. J. Carrion, C. Espejo, J. Sanes); 2. Nano and micro PTFE for surface lubrication of carbon fabric reinforced polyethersulphone composites (Jayashree Bijwe, Mohit Sharma); 3. Tribology of MoS{sub 2}-based nanocomposites (Kunhong Hu, Xianguo Hu, Yufu Xu, Xiaojun Sun, Yang Jiang); 4. Friction and wear of Al{sub 2}O{sub 3}-based composites with dispersed and agglomerated nanoparticles (Jinjun Lu, Jian Shang, Junhu Meng, Tao Wang); and 5. Wear of multi-scale phase reinforced composites (Zhenyu Jiang, Zhong Zhang).

  20. Second-Order Solutions for Random Interfacial Waves Under Steady Uniform Currents

    Institute of Scientific and Technical Information of China (English)

    SONG Jin-bao

    2005-01-01

    In the present research, the study of Song (2004) for random interfacial waves in two-layer fluid is extended to the case of fluids moving at different steady uniform speeds. The equations describing the random displacements of the density interface and the associated velocity potentials in two-layer fluid are solved to the second order, and the wave-wave interactions of the wave components and the interactions between the waves and currents are described. As expected, the extended solutions include those obtained by Song (2004) as one special case where the steady uniform currents of the two fluids are taken as zero, and the solutions reduce to those derived by Sharma and Dean (1979) for random surface waves if the density of the upper fluid and the current of the lower fluid are both taken as zero.

  1. AN EXPERIMENTAL STUDY ON HEAT TRANSFER AND FRICTION FACTOR OF AL2O3 NANOFLUID

    Directory of Open Access Journals (Sweden)

    K.V. Sharma

    2011-12-01

    Full Text Available L. Syam Sundar1 and K.V. Sharma2This paper reports experimental investigations of fully developed laminar convective heat transfer and friction factor characteristics of different volume concentrations of Al2O3 nanofluid in a plain tube, fitted with different twist ratios of twisted tape inserts. Experiments are conducted with water and nanofluid in the range of 700

  2. Almost Graded Prime Ideals

    Directory of Open Access Journals (Sweden)

    Ameer Jaber

    2008-01-01

    Full Text Available Problem Statement: Graded commutative ring with unity over an abelian group were introduced by many authors such as T. Y. Lam and C. T. C. Wall, and almost prime ideals over commutative rings with unity were introduced by S.M. Batwadeker and P.K. Sharma, and this forced us to try to extend the theory of almost and n-almost prime ideals to the graded case. Approach: We develop the theory of almost and n-almost prime ideals to the graded case. Results: We extended some basic results about almost and n-almost prime ideals to the graded case, and then we gave a relationship between n-almost graded prime ideals and weakly graded prime ideals. Conclusion: The extended results about almost and n-almost graded prime ideals allow us to classify further properties about almost graded prime ideals. 2000 AMS Mathematics Subject Classification: 13 A 02.

  3. Interacting electrons in ballistic conformal billiard quantum dots

    Science.gov (United States)

    Murthy, Ganpathy; Mathur, Harsh; Shankar, Ramamurti

    2004-03-01

    Interacting electrons in a ballistic quantum dot present a novel regime of disorder + interactions. An instability of the ground state towards a spontaneous deformation of the Fermi surface (the Pomeranchuk transition) has been found by the present authors[1], by assuming that Random Matrix Theory describes the states in the Thouless shell near the Fermi energy. However, the question of whether the mesoscopic transition occurs before the bulk transition remains open[2]. Here we describe calculations on the conformal billiard[3] and attempt to see how well RMT assumptions hold, and to what extent the physics of the transition is described by our previous work. 1. G. Murthy, R. Shankar, D. Herman, and H. Mathur, cond-mat/0306529. 2. S. Adam, P. W. Brouwer, and P. Sharma, cond-mat/0309074. 3. M. V. Berry and M. Robnik, J. Phys. A19, 669 (1986).

  4. A Study To Evaluate Skills Of Ophthalmic Assistants For Assessment Of Cup Disc Ratio

    Directory of Open Access Journals (Sweden)

    Malik J.S

    1999-01-01

    Full Text Available Research question: 1. Whether paramedical ophthalmic assistants can be trained to examine vertical cup disc ratio? 2. Can the PMO As detect abnormal cup disc ratio after training? Objectives: 1. T o train ophthalmic assistants in cup disc ratio examination 2. To evaluate skills of trained ophthalmic assistants in cup disc ratio examination Study design: Cross sectional Setting: OPD of Ophthalmology department, Pt. B.D. Sharma PGIMS, Rohtak Participants: Five paramedical ophthalmic assistants, one ophthalmologist and 322 patients above 40 years of age. Statistical analysis: Sensitivity, specificity, Kappa values. Results: Data analysis of 322 cases was found by PMO As and ophthalmologist revealed sensitivity between 50-65% and specificity between 84.5-92.62%. A good agreement was found among all the examiners on computation of Kappa Values. It was concluded that ophthalmic assistants can examine vertical cup disc ratio after five days training.

  5. Resolving the mesospheric nighttime 4.3 µm emission puzzle: Laboratory demonstration of new mechanism for OH(υ) relaxation

    Science.gov (United States)

    Kalogerakis, Konstantinos S.; Matsiev, Daniel; Sharma, Ramesh D.; Wintersteiner, Peter P.

    2016-09-01

    We report laboratory results that support a recently proposed mechanism for relaxation of highly vibrationally excited hydroxyl radical by ground-state oxygen atoms (Sharma et al., GRL 42, 4639-4647 (2015)). According to this mechanism, which eventually leads to an enhancement of nocturnal 4.3 µm CO2 emissions in the mesosphere, the deactivation of OH(high υ) by O(3P) involves a fast, spin-allowed, multiquantum vibration-to-electronic (V-E) energy transfer process generating O(1D). We present laser-based experiments that demonstrate these energy transfer processes in action and discuss some implications of the new mechanism for mesospheric OH. These developments represent a breakthrough addressing the long-standing problem of unacceptably large discrepancies between models and observations of the nocturnal mesospheric 4.3 µm emission.

  6. Abnormal Waves Modelled as Second-order Conditional Waves

    DEFF Research Database (Denmark)

    Jensen, Jørgen Juncher

    2005-01-01

    The paper presents results for the expected second order short-crested wave conditional of a given wave crest at a specific point in time and space. The analysis is based on the second order Sharma and Dean shallow water wave theory. Numerical results showing the importance of the spectral density......, the water depth and the directional spreading on the conditional mean wave profile are presented. Application of conditional waves to model and explain abnormal waves, e.g. the well-known New Year Wave measured at the Draupner platform January 1st 1995, is discussed. Whereas the wave profile can be modelled...... quite well by the second order conditional wave including directional spreading and finite water depth the probability to encounter such a wave is still, however, extremely rare. The use of the second order conditional wave as initial condition to a fully non-linear three-dimensional analysis...

  7. COMPUTATIONAL TECHNIQUE FOR FLOW IN BLOOD VESSELS WITH POROUS EFFECTS

    Institute of Scientific and Technical Information of China (English)

    Anil Kumar; C.L.Varshney; G.C.Sharma

    2005-01-01

    A finite element solution for the Navier-Stokes equations for steady flow under the porosity effects through a double branched two-dimensional section of a threedimensional model of a canine aorta was obtained. The numerical solution involves transforming a physical coordinates to a curvilinear boundary fitted coordinate system. The steady flow, branch flow and shear stress under the porous effects were discussed in detail.The shear stress at the wall was calculated for Reynolds number of 1 000 with branch to main aortic flow rate ratio as a parameter. The results are compared with earlier works involving experimental data and it has been observed that our results are very close to the exact solutions. This work is in fact an improvement of the work of Sharma et al. (2001) in the sense that computational technique is economic and Reynolds number is large.

  8. Bladder injuries frequently missed in polytrauma patients

    Directory of Open Access Journals (Sweden)

    Tanweer Karim

    2010-05-01

    Full Text Available Tanweer Karim, Margaret Topno, Vinod Sharma, Raymond Picardo, Ankur HastirSurgery, MGM Medical College, Kamothe, Navi Mumbai, IndiaAbstract: Bladder injuries are very common in patients who have had road traffic accidents. The method of diagnosis and management of such injuries is well established and accepted. However, trauma to the bladder can be associated with other life-threatening injuries which are frequently missed, and often diagnosed during laparotomy for other reasons. The aim of this study was to diagnose bladder injury in polytrauma patients as early as possible, taking into consideration the fact that these patients are hemodynamically unstable and require rapid evaluation and management. In order to achieve our objective, we used bedside sonography with retrograde instillation of normal saline to diagnose bladder injury in addition to use of the conventional retrograde cystogram.Keywords: bladder injury, bladder rupture, retrograde cystogram

  9. A new exact anisotropic solution of embedding class one

    Energy Technology Data Exchange (ETDEWEB)

    Maurya, S.K.; Smitha, T.T. [University of Nizwa, Department of Mathematical and Physical Sciences, College of Arts and Science, Nizwa (Oman); Gupta, Y.K. [Raj Kumar Goel Institute of Technology, Department of Mathematics, Ghaziabad (India); Rahaman, Farook [Jadavpur University, Department of Mathematics, Kolkata, West Bengal (India)

    2016-07-15

    We have presented a new anisotropic solution of Einstein's field equations for compact-star models. Einstein's field equations are solved by using the class-one condition (S.N. Pandey, S.P. Sharma, Gen. Relativ. Gravit. 14, 113 (1982)). We constructed the expression for the anisotropy factor (Δ) by using the pressure anisotropy condition and thereafter we obtained the physical parameters like energy density, radial and transverse pressure. These models parameters are well-behaved inside the star and satisfy all the required physical conditions. Also we observed the very interesting result that all physical parameters depend upon the anisotropy factor (Δ). The mass and radius of the present compact-star models are quite compatible with the observational astrophysical compact stellar objects like Her X-1, RXJ 1856-37, SAX J1808.4-3658(SS1), SAX J1808.4-3658(SS2). (orig.)

  10. Riding pontic: a tool to keep patients smiling.

    Science.gov (United States)

    Sharma, Narendra Shriram

    2013-05-01

    All patients expect a beautiful smile at the completion of orthodontic treatment, but some patients show concern regarding their appearance while undergoing treatment. The appearance of a gap from a missing tooth can be a concern, especially if it is in the display zone of a patient's smile. If the treatment plan includes prosthetic replacement of the missing tooth rather then space closure, then space maintenance is also an issue. In an appearance conscious patient use of riding pontic as space maintainers is a good option during treatment. How to cite this article: Sharma NS. Riding Pontic: A Tool to Keep Patients Smiling. Int J Clin Pediatr Dent 2013;6(2): 127-131.

  11. Riding Pontic: A Tool to Keep Patients Smiling

    Science.gov (United States)

    Sharma, Narendra Shriram

    2013-01-01

    ABSTRACT All patients expect a beautiful smile at the completion of orthodontic treatment, but some patients show concern regarding their appearance while undergoing treatment. The appearance of a gap from a missing tooth can be a concern, especially if it is in the display zone of a patient's smile. If the treatment plan includes prosthetic replacement of the missing tooth rather then space closure, then space maintenance is also an issue. In an appearance conscious patient use of riding pontic as space maintainers is a good option during treatment. How to cite this article: Sharma NS. Riding Pontic: A Tool to Keep Patients Smiling. Int J Clin Pediatr Dent 2013;6(2): 127-131. PMID:25206207

  12. FINITE ELEMENT GALERKIN APPROACH FOR A COMPUTATIONAL STUDY OF ARTERIAL FLOW

    Institute of Scientific and Technical Information of China (English)

    G.C.Sharma(G.C.夏玛); Madhu Jain(马德胡·珍); Anil Kumar(阿尼尔·克乌玛)

    2001-01-01

    A finite element solution for the Navier-Stokes equations for steady flow through a double branched two dimensional section of three dimensional model of canine aorta is obtained. The numerical technique involves transformation of the physical coordinates to a curvilinear boundary fitted coordinate system. The shear stress at the wall is calculated for Reynolds number of 1000 with branch to main aortic flow rate ratio as a parameter. The results are compared with earlier works involving experimental data and it is observed that the results are very close to their solutions. This work in fact is an improvement of the work of Sharma and Kapoor (1995) in the sense that computations scheme is economic and Reynolds number is large.

  13. Conditional Short-crested second order waves in shallow water and with superimposed current

    DEFF Research Database (Denmark)

    Jensen, Jørgen Juncher

    2004-01-01

    For bottom-supported offshore structures like oil drilling rigs and oil production platforms, a deterministic design wave approach is often applied using a regular non-linear Stokes' wave. Thereby, the procedure accounts for non-linear effects in the wave loading but the randomness of the ocean...... wave, given the value of the wave crest at a specific point in time or space. In the present paper a derivation of the expected second order short-crested wave riding on a uniform current is given. The analysis is based on the second order Sharma and Dean shallow water wave theory and the direction...... of the main wind direction can make any direction with the current. Numerical results showing the importance of the water depth, the directional spreading and the current on the conditional mean wave profile and the associated wave kinematics are presented. A discussion of the use of the conditional wave...

  14. Pericardio-diaphragmatic rupture following blunt abdominal trauma: Case report and review of literature

    Science.gov (United States)

    Abou Hussein, Bassem; Khammas, Ali; Kaiyasah, Hadiel; Swaleh, Abeer; Al Rifai, Nazim; Al-Mazrouei, Alya; Badri, Faisal

    2015-01-01

    Introduction Traumatic diaphragmatic rupture (TDR) occurs in 0–5% of patients with major blunt thoraco-abdominal trauma, in most of them on the left side, and an early correct diagnosis is made in less than half of the cases (Meyers and McCabe, 1993; Ball et al., 1982). Presentation of the case We report a case of a forty-eight years old man who had a pericardio-diaphragmatic rupture after a high-velocity blunt abdominal trauma that was diagnosed and treated successfully. Discussion Pericardio-diaphragmatic rupture (PDR) is an uncommon problem that poses a diagnostic challenge to surgeons. The incidence of PDR is between 0.2% and 3.3% of cases with TDR (Sharma, 1999 [3]). Conclusion PDR should be suspected in any patient with high velocity thoraco-abdominal trauma. Early diagnosis is essential and needs a high index of suspicion. Early Management is important in decreasing morbidity and mortality. PMID:26773877

  15. On coherent structure in wall turbulence

    CERN Document Server

    Sharma, A S

    2013-01-01

    A new theory of coherent structure in wall turbulence is presented. The theory is the first to predict packets of hairpin vortices and other structure in turbulence, and their dynamics, based on an analysis of the Navier-Stokes equations, under an assumption of a turbulent mean profile. The assumption of the turbulent mean acts as a restriction on the class of possible structures. It is shown that the coherent structure is a manifestation of essentially low-dimensional flow dynamics, arising from a critical layer mechanism. Using the decomposition presented in McKeon & Sharma (J. Fluid Mech, 658, 2010), complex coherent structure is recreated from minimal superpositions of response modes predicted by the analysis, which take the form of radially-varying travelling waves. By way of example, simple combinations of these modes are offered that predicts hairpins and modulated hairpin packets. The phase interaction also predicts important skewness and correlation results known in the literature. It is also sho...

  16. Stochastic multi-reference perturbation theory with application to linearized coupled cluster method

    CERN Document Server

    Jeanmairet, Guillaume; Alavi, Ali

    2016-01-01

    In this article we report a stochastic evaluation of the recently proposed LCC multireference perturbation theory [Sharma S., and Alavi A., J. Chem. Phys. 143, 102815, (2015)]. In this method both the zeroth order and first order wavefunctions are sampled stochastically by propagating simultaneously two populations of signed walkers. The sampling of the zeroth order wavefunction follows a set of stochastic processes identical to the one used in the FCIQMC method. To sample the first order wavefunction, the usual FCIQMC algorithm is augmented with a source term that spawns walkers in the sampled first order wavefunction from the zeroth order wavefunction. The second order energy is also computed stochastically but requires no additional overhead outside of the added cost of sampling the first order wavefunction. This fully stochastic method opens up the possibility of simultaneously treating large active spaces to account for static correlation and recovering the dynamical correlation using perturbation theory...

  17. Combining internally contracted states and matrix product states to perform multireference perturbation theory

    CERN Document Server

    Sharma, Sandeep; Guo, Sheng; Alavi, Ali

    2016-01-01

    We present two efficient and intruder-free methods for treating dynamic correlation on top of general multi-configuration reference wave functions---including such as obtained by the density matrix renormalization group (DMRG) with large active spaces. The new methods are the second order variant of the recently proposed multi-reference linearized coupled cluster method (MRLCC) [S. Sharma, A. Alavi, J. Chem. Phys. 143, 102815 (2015)], and of N-electron valence perturbation theory (NEVPT2), with expected accuracies similar to MRCI+Q and (at least) CASPT2, respectively. Great efficiency gains are realized by representing the first-order wave function with a combination of internal contraction (IC) and matrix product state perturbation theory (MPSPT). With this combination, only third order reduced density matrices (RDMs) are required. Thus, we obviate the need for calculating (or estimating) RDMs of fourth or higher order; these had so far posed a severe bottleneck for dynamic correlation treatments involving t...

  18. On eccentric connectivity index

    CERN Document Server

    Zhou, Bo

    2010-01-01

    The eccentric connectivity index, proposed by Sharma, Goswami and Madan, has been employed successfully for the development of numerous mathematical models for the prediction of biological activities of diverse nature. We now report mathematical properties of the eccentric connectivity index. We establish various lower and upper bounds for the eccentric connectivity index in terms of other graph invariants including the number of vertices, the number of edges, the degree distance and the first Zagreb index. We determine the n-vertex trees of diameter with the minimum eccentric connectivity index, and the n-vertex trees of pendent vertices, with the maximum eccentric connectivity index. We also determine the n-vertex trees with respectively the minimum, second-minimum and third-minimum, and the maximum, second-maximum and third-maximum eccentric connectivity indices for

  19. Electron transport and Goos-Haenchen shift in graphene with electric and magnetic barriers: optical analogy and band structure

    Energy Technology Data Exchange (ETDEWEB)

    Sharma, Manish [Centre for Applied Research in Electronics, Indian Institute of Technology Delhi, New Delhi-110016 (India); Ghosh, Sankalpa [Department of Physics, Indian Institute of Technology Delhi, New Delhi-110016 (India)

    2011-02-09

    Transport of massless Dirac fermions in graphene monolayers is analysed in the presence of a combination of singular magnetic barriers and applied electrostatic potential. Extending a recently proposed (Ghosh and Sharma 2009 J. Phys.: Condens. Matter 21 292204) analogy between the transmission of light through a medium with modulated refractive index and electron transmission in graphene through singular magnetic barriers to the present case, we find the addition of a scalar potential profoundly changes the transmission. We calculate the quantum version of the Goos-Haenchen shift that the electron wave suffers upon being totally reflected by such barriers. The combined electric and magnetic barriers substantially modify the band structure near the Dirac point. This affects transport near the Dirac point significantly and has important consequences for graphene-based electronics.

  20. Electron transport and Goos-Hänchen shift in graphene with electric and magnetic barriers: optical analogy and band structure.

    Science.gov (United States)

    Sharma, Manish; Ghosh, Sankalpa

    2011-02-09

    Transport of massless Dirac fermions in graphene monolayers is analysed in the presence of a combination of singular magnetic barriers and applied electrostatic potential. Extending a recently proposed (Ghosh and Sharma 2009 J. Phys.: Condens. Matter 21 292204) analogy between the transmission of light through a medium with modulated refractive index and electron transmission in graphene through singular magnetic barriers to the present case, we find the addition of a scalar potential profoundly changes the transmission. We calculate the quantum version of the Goos-Hänchen shift that the electron wave suffers upon being totally reflected by such barriers. The combined electric and magnetic barriers substantially modify the band structure near the Dirac point. This affects transport near the Dirac point significantly and has important consequences for graphene-based electronics.

  1. Conference held in Memory of U. N. Singh

    CERN Document Server

    Singh, D

    1992-01-01

    From the Contents: A. Lambert: Weighted shifts and composition operators on L2; - A.S.Cavaretta/A.Sharma: Variation diminishing properties and convexityfor the tensor product Bernstein operator; - B.P. Duggal: A note on generalised commutativity theorems in the Schatten norm; - B.S.Yadav/D.Singh/S.Agrawal: De Branges Modules in H2(Ck) of the torus; - D. Sarason: Weak compactness of holomorphic composition operators on H1; - H.Helson/J.E.McCarthy: Continuity of seminorms; - J.A. Siddiqui: Maximal ideals in local Carleman algebras; - J.G. Klunie: Convergence of polynomials with restricted zeros; - J.P. Kahane: On a theorem of Polya; - U.N. Singh: The Carleman-Fourier transform and its applications; - W. Zelasko: Extending seminorms in locally pseudoconvex algebras;

  2. Conditional Short-crested second order waves in shallow water and with superimposed current

    DEFF Research Database (Denmark)

    Jensen, Jørgen Juncher

    2004-01-01

    wave, given the value of the wave crest at a specific point in time or space. In the present paper a derivation of the expected second order short-crested wave riding on a uniform current is given. The analysis is based on the second order Sharma and Dean shallow water wave theory and the direction......For bottom-supported offshore structures like oil drilling rigs and oil production platforms, a deterministic design wave approach is often applied using a regular non-linear Stokes' wave. Thereby, the procedure accounts for non-linear effects in the wave loading but the randomness of the ocean...... waves is poorly represented, as the shape of the wave spectrum does not enter the wave kinematics. To overcome this problem and still keep the simplicity of a deterministic approach, Tromans, Anaturk and Hagemeijer (1991) suggested the use of a deterministic wave, defined as the expected linear Airy...

  3. New species and records of Asymmetrasca (Hemiptera: Cicadellidae: Typhlocybinae: Empoascini) from China and name changes in Empoasca (Matsumurasca).

    Science.gov (United States)

    Liu, Yang; Fletcher, Murray J; Dietrich, Christopher H; Zhang, Ya-Lin

    2014-01-01

    Six new species of Asymmetrasca Dlabola are described from China: A. dahaituoensis, A. helica, A. hypercurvata, A. liaoensis, A. reflexilis, A. uncus spp. nov. In addition, A. cienka Dworakowska, 1982, n. comb.; A. decedens Paoli, 1932 and A. sakaii Dworakowska 1971, n. comb., are recorded from China for the first time. The following additional new combinations from Empoasca are also proposed: A. cisiana (Dworakowska, 1971); A. kaicola (Dworakowska, 1982), A. lutowa (Dworakowska, 1971), A. mona (Dworakowska, 1994), A. nipponica (Dworakowska 1982), A. rybiogon (Dworakowska, 1971), and A. uniprossicae (Sohi, 1977). Empoasca (Empoasca) kishtwarensis Sharma, 1984 is proposed as a new synonym of Asymmetrasca kaicola (Dworakowska, 1982). Habitus photos and illustrations of the male genitalia of the new species and a key to Chinese species are provided. New names are proposed to replace two junior homonyms in Empoasca (Matsumurasca).

  4. Asthma control limitations in selected primary health care clinics

    Directory of Open Access Journals (Sweden)

    Jan J. Gerber

    2009-04-01

    Full Text Available Primary health care services worldwide are currently experiencing many quality-related problems. Efforts to improve these services appear to be sporadic and unsatisfactory. Investigations have revealed (Sharma & Sharma 2007 that one of the main causes for this state of affairs can be identif ed as neglected or inadequate documentation of patient/case history. The health care provider (HCP should be equipped to improve the quality of health care and to take the lead in assuaging the predicament.

    The present study was undertaken to assess the correlation between asthma control and patient-related case history notes as recorded via the HCP. The data were obtained retrospectively from the patient notes of all asthmatic patients (including children and pregnant women who attended six selected clinics in the North West Province of South Africa (Dr Kenneth Kaunda Municipal District.

    The analysis of the data collected from the patient clinic books confirmed the suspicion of poor quality of documentation, although the documentation in certain categories rendered some positive results. When compared to the GINA® guidelines, none of the patients had been controlled properly and only a small number (18.4% had been controlled partly (GINA 2008. Asthma control may be enhanced when a standard template is developed for completion by the HCP. It is envisaged that this will ensure that vital information regarding asthma control is documented in order to contribute to satisfactory chronic disease control.

    Opsomming

    Primêre gesondheidsorgdienste wêreldwyd ondervind tans menige gehaltediens-verwante probleme, terwyl pogings om dit te verbeter sporadies en onbevredigend voorkom. Navorsing toon (Sharma & Sharma, 2007 dat een van die hoofoorsake hiervan die onvoldoende dokumentasie van die pasiënt of die geval se geskiedenis of nalating om te dokumenteer, is. Die gesondheidsorgverskaffer (GSV moet toegerus word om die gehalte

  5. Four newly recorded species of Dryopteridaceae from Kashmir valley, India

    Directory of Open Access Journals (Sweden)

    SHAKOOR AHMAD MIR

    2014-04-01

    Full Text Available Mir SA, Mishra AK, Reshi ZA, Sharma MP. 2014. Four newly recorded species of Dryopteridaceae from Kashmir valley, India. Biodiversitas 15: 6-11. Habitat diversity, elevation, cloud cover, rainfall, seasonal and temperature variations have created many ideal sites for the luxuriant growth of pteridophytes in the Kashmir valley, yet all the regions of the valley have not been surveyed. In Kashmir valley the family Dryopteridaceae is represented by 31 species. During the recent extensive field surveys of Shopian district four more species viz., Dryopteris caroli-hopei Fraser-Jenkins, Dryopteris blanfordii subsp. nigrosquamosa (Ching Fraser-Jenkins, Dryopteris pulvinulifera (Bedd. Kuntze and Polystichum Nepalense (Spreng C. Chr. have been recorded for the first time from the valley. The taxonomic description, synonyms, distribution and photographs of each species are given in this article.

  6. Plants utilization by the communities of Bharsar and adjoining area of Pauri Garhwal District, Uttarakhand, India

    Directory of Open Access Journals (Sweden)

    ANAND S. BISHT

    2014-04-01

    Full Text Available Bisht AS, Sharma KD. 2014. Plants utilization by the communities of Bharsar and adjoining area of Pauri Garhwal District, Uttarakhand, India. Biodiversitas 15: 92-98. Garhwal Himalaya possesses luxuriant a varied vegetation with in the Himalaya region. Almost every plant has economic value in the form of shelter, food, water, medicine, fuel and industrial products and fodder. Surveys were conducted in entire Bharsar, Pauri Garhwal district of Uttarakhand, India in order to get information on traditional uses of plants by local inhabitants. A total of 169 plants were collected of which 40 species of vegetables, 19 species of forest and agroforestry, 24 species of ornamental flower, 71 species of less known medicinal plants and 15 species of agricultural crops were found economically important as they are used by the people frequently for various purposes.

  7. A new thermogeomechanical theory for gravity drainage in SAGD

    Energy Technology Data Exchange (ETDEWEB)

    Cokar, M.; Kallos, M.S.; Gates, I.D. [Dept. of Chemical and Petroleum Engineering, University of Calgary (Canada)

    2011-07-01

    In the heavy oil and bitumen industry, the steam assisted gravity drainage (SAGD) process is often used to enhance oil recovery. In such deposits, oil usually has no mobility due to its high viscosity and the injection of steam leads to an increase in the mobility of bitumen. Since the thermogeomechanical evolution of the oil sand at the chamber edge is important to the SAGD's performance, this paper aimed at taking these effects into account in a new SAGD drainage formula. The SAGD theory was modified to incorporate the effects of geomechanics and the results were then compared with Butler's model and the Sharma and Gates model. Results showed that thermal expansion has an important impact on oil rates and that geomechanical effects need to be considered when analysing the flow at the edge of steam chambers. This study developed a SAGD drainage formula and demonstrated the importance of geomechanics in the SAGD's performance.

  8. Model-based scaling and prediction of the streamwise energy intensity in high-Reynolds number turbulent channels

    CERN Document Server

    Moarref, Rashad; Tropp, Joel A; McKeon, Beverley J

    2013-01-01

    We study the Reynolds number scaling of a gain-based, low-rank approximation to turbulent channel flows, determined by the resolvent formulation of McKeon & Sharma (2010), in order to obtain a description of the streamwise turbulence intensity from direct consideration of the Navier-Stokes equations. Under this formulation, the velocity field is decomposed into propagating waves (with single streamwise and spanwise wavelengths and wave speed) whose wall-normal shapes are determined from the principal singular function of the corresponding resolvent operator. We establish that the resolvent formulation admits three classes of wave parameters that induce universal behavior with Reynolds number on the low-rank model, and which are consistent with scalings proposed throughout the wall turbulence literature. For the rank-1 model subject to broadband forcing, the integrated streamwise energy density takes a universal form which is consistent with the dominant near-wall turbulent motions. When the shape of the f...

  9. Roscovitine regulates invasive breast cancer cell (MDA-MB231) proliferation and survival through cell cycle regulatory protein cdk5.

    Science.gov (United States)

    Goodyear, Shaun; Sharma, Mahesh C

    2007-02-01

    Roscovitine, a purine analogue, has been considered for the treatment of cancer. Anti-cancer therapeutic efficacy is being evaluated in clinical trials. However, the mechanisms remain unclear. In the present study, cyclic-dependent kinase 5 (cdk5) proved to be a molecular target for roscovitine-triggered apoptosis for highly invasive breast cancer cell death. Because our previous studies have shown a potential role of cdk5 in endothelial cell proliferation/apoptosis [Sharma, M.R., Tuszynski, G.P., Sharma, M.C. (2004). Angiostatin-induced inhibition of endothelial cell proliferation/apoptosis is associated with the down-regulation of cell cycle regulatory protein cdk5. J. Cell Biochem. 91, 398-409], here we not only demonstrate first that Cdk5, p35, and p25 proteins were all expressed in invasive breast cancer cells MDA-MB231 but also showed that cdk5 expression regulates MDA-MB231 cell proliferation. In addition, potent mitogen bFGF up-regulates cdk5 expression. Roscovitine specifically inhibits cdk5 expression/activity in a dose-dependent manner with concomitant inhibition of MDA-MB231 cell proliferation and induction of apoptosis. By contrast, the roscovitine analog olomoucine, a specific inhibitor of cdk4, failed to affect MDA-MB231 cell proliferation and apoptosis which implies the specific involvement of cdk5 in roscovitine-triggered cell death/proliferation. Additionally, roscovitine-mediated inhibition of proliferation is irreversible. These data suggest that cdk5 may have a significant role in the regulation of breast cancer cell proliferation and apoptosis and extend beyond its role in neurogenesis. These results suggest that Cdk5 is a novel player in roscovitine-triggered breast cancer cell apoptosis and inhibition of proliferation, therefore, may be a potential therapeutic target.

  10. Understanding the application of stem cell therapy in cardiovascular diseases

    Directory of Open Access Journals (Sweden)

    Sharma RK

    2012-10-01

    Full Text Available Rakesh K Sharma, Donald J Voelker, Roma Sharma, Hanumanth K ReddyUniversity of Arkansas for Medical Sciences, Medical Center of South Arkansas, El Dorado, AR, USAAbstract: Throughout their lifetime, an individual may sustain many injuries and recover spontaneously over a period of time, without even realizing the injury in the first place. Wound healing occurs due to a proliferation of stem cells capable of restoring the injured tissue. The ability of adult stem cells to repair tissue is dependent upon the intrinsic ability of tissues to proliferate. The amazing capacity of embryonic stem cells to give rise to virtually any type of tissue has intensified the search for similar cell lineage in adults to treat various diseases including cardiovascular diseases. The ability to convert adult stem cells into pluripotent cells that resemble embryonic cells, and to transplant those in the desired organ for regenerative therapy is very attractive, and may offer the possibility of treating harmful disease-causing mutations. The race is on to find the best cells for treatment of cardiovascular disease. There is a need for the ideal stem cell, delivery strategies, myocardial retention, and time of administration in the ideal patient population. There are multiple modes of stem cell delivery to the heart with different cell retention rates that vary depending upon method and site of injection, such as intra coronary, intramyocardial or via coronary sinus. While there are crucial issues such as retention of stem cells, microvascular plugging, biodistribution, homing to myocardium, and various proapoptotic factors in the ischemic myocardium, the regenerative potential of stem cells offers an enormous impact on clinical applications in the management of cardiovascular diseases.Keywords: stem cell therapy, stem cell delivery, cardiovascular diseases, myocardial infarction, cardiomyopathy

  11. Variability of drought characteristics in Europe over the last 250 years

    Science.gov (United States)

    Hanel, Martin; Rakovec, Oldrich; Máca, Petr; Markonis, Yannis; Samaniego, Luis; Kumar, Rohini

    2017-04-01

    The mesoscale hydrological model (mHM) with spatial resolution 0.5deg is applied to simulate water balance across large part of continental Europe (excluding Scandinavia and Russia) for the period 1766-2015. The model is driven by available European gridded monthly temperature and precipitation reconstructions (Casty et al, 2007), which are disaggregated into daily time step using k-nearest neighbour resampling (Lall and Sharma, 1996). To quantify the uncertainty due to temporal disaggregation, several replicates of precipitation and temperature fields for the whole period are considered. In parallel, model parameter uncertainty is addressed by an ensemble of parameter realizations provided by Rakovec et al (2016). Deficit periods with respect to total runoff and soil moisture are identified at each grid cell using the variable threshold method. We assess the severity and intensity of drought, spatial extent of area under drought as well as the length of deficit periods. In addition, we also determine the occurrence of multi-year droughts during the period and evaluate the extremity of recent droughts in Europe (i.e., 2003, 2015) in the context of the whole multi-decadal record. References: Casty, C., Raible, C.C., Stocker, T.F., Luterbacher, J. and H. Wanner (2007), A European pattern climatology 1766-2000, Climate Dynamics, 29(7), DOI:10.1007/s00382-007-0257-6. Lall, U., and A. Sharma (1996), A Nearest neighbor bootstrap for resampling hydrologic time series, Water Resour. Res., 32(3), 679-693, DOI:10.1029/95WR02966. Rakovec, O., Kumar, R., Attinger, S. and Samaniego, L. (2016), Improving the realism of hydrologic model functioning through multivariate parameter estimation, Water Resour. Res., 52, DOI:10.1002/2016WR019430

  12. Basavarajeeyam: A historical perspective.

    Science.gov (United States)

    Nishteswar, K

    2011-10-01

    Basavarajeeyam is an important handbook for an Ayurvedic physician of Andhra region. It is a bilingual work and the content was presented in Sanskrit and Telugu languages. With regard to the place and date of Basavarajeeyam there is no common opinion among the present day scholars. Pt Govardhana Sharma Changani in his introduction to the Sanskrit version of Basavarajeeyam exposed a historical profile of Basavrajeeyam picturising him as Basava who was a staunch follower of Veerashaivism and a contemporary of king Bijjala (end of 12(th) cent. AD). The same statement is carried out in the works of Ayurvedic Itihasa written by Atredeva Vidyawalkan and Acharya Priyavrata Sharma. It appears that the historical evidence shown by these scholars is one sided and cannot stand any reason. Basavraju stated that he had started writing this work after a thorough study of many works such as Charaka, Nithyanatheeyam (1360 AD), Revenakalpam, Pujyapadiyam, Bahatam, Kashikhandam (1435 AD) etc. Basavraju has faithfully reproduced certain chapter of Vaidyachintamani, which is considered to be a work of 15(th) century. Basavraju not only mentioned Phirangiroga in the index of diseases described by him at the end of the book, but also indicated Phirangichekka (Madhusnuhi) in the management of Meharoga and Granthi. By this evidence Basavarajiyam should be considered as the work of post Bhavaprakasha period. Basavraju indicates in the Gulmaroga Chikitsa that Sankhadravaka should be administered in the dose of 'Ekanni'. The name Ekanni was given for a copper coin which came in to circulation of money during British India produced from Madras mint (1794 AD). Based on these internal evidences, it can be safely concluded that Basavraju belong to 18(th)century.

  13. Childhood obesity: prevention is better than cure

    Directory of Open Access Journals (Sweden)

    Pandita A

    2016-03-01

    Full Text Available Aakash Pandita,1 Deepak Sharma,2 Dharti Pandita,3 Smita Pawar,4 Mir Tariq,5 Avinash Kaul6 1Department of Pediatrics, SMGS Hospital Jammu, Jammu and Kashmir, India; 2Department of Pediatrics, Pt Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India; 3Department of Microbiology Jammu University, Jammu, Jammu and Kashmir, India; 4Department of OBG Fernandez Hospital, Hyderabad,Telangana, India; 5Department of Orthopedics, Kokilaben Dhirubhai Ambani Hospital, Mumbai, India; 6Department of Surgery, Acharya Shri Chander College of Medical Sciences and Hospital, Jammu, Jammu and Kashmir, India Abstract: Obesity and its associated comorbidities have emerged as a major health problem garnering interests from both public health agencies and mainstream media consumers. With increasing awareness on its impact on health, finances, and community at large, it has come to the forefront for scientific research and development of health plans. The need for better strategies and novel interventions to manage obesity is now being recognized by the entire health care system. Obesity and overweight is now the fifth leading global risk factor for mortality. Strategic investment is thus urgently needed to implement population-based childhood obesity prevention programmes which are effective and also culturally appropriate. Population-based prevention is crucial to stem this rising tide of childhood obesity which is fast reaching epidemic proportions. Obesity has its onset very early in life; therefore, children constitute a major group of this disease. It is thus imperative to lay utmost importance on prevention of obesity in children and herald its progress, if present already. Furthermore, treatment is still in preliminary stage, so early prevention holds better than treatment at later stages. This article is an attempt to lay emphasis on childhood obesity as a problem that needs to be recognized early and measures for its

  14. Effects of Roads on Amphibian Populations

    DEFF Research Database (Denmark)

    Hels, T.

    to have experienced the wonders of early summer sunrises in the field - and the joy of thawing out frozen fingers after hours of field work around freezing point. Amphibian populations are declining. This worrying fact is what has initiated this work. Some fifty years ago, the life history of frogs...... is the result of my three year PhD study at the National Environmental Research Institute, Kalø, and University of Copenhagen. Funded by NERI, the Danish Research Academy, and the Danish Road Directorate, it has dealt mainly with the effects of traffic and roads on amphibian populations. The Spadefoot toad...... of Spadefoot toads (Pelobates fuscus Laur.) II The effect of road kills on amphibian populations III Simulating viability of a Spadefoot toad (P. fuscus) metapopulation in a landscape fragmented by a road The manuscripts are preceded by a synopsis which sums up the work and puts it into a broader perspective...

  15. KIRSAL ve KENTSEL KESİMLERDE TÜKETİM VE TASARRUF KALIPLARI GENİŞLETİLMİŞ DOĞRUSAL HARCAMA SİSTEMİ UYGULAMASI

    OpenAIRE

    Nışancı, Murat

    2010-01-01

    Özet: Bu çalışmada ELES modeli kullanılarak, Türkiye'de kırsal vckentsel kesimlerde bölgelere göre gelir, fiyat ve tasarruf esneklik tahminleribulunarak tüketici davranış kalıpları analiz edilmeye çalışılmıştır. Kırsal vekentsel bölgelerde marjinal tüketim eğiliminin çok değişken ve önemli ölçüdekliçük değerlere sahip olduğu bulunmuştur...

  16. Kinetics Model of Thermal Decomposition Reaction of Aluminum Potassim Sulphate%硫酸铝钾热分解反应动力学模型

    Institute of Scientific and Technical Information of China (English)

    张建军; 魏海玉; 任志强

    2001-01-01

    The thermal decomposition process of KAl(SO4)2·12H2O and its kinetics has been studied by TG-DTG. By Dollimore method, D3 is defined as the second step of thermal decomposition kinetic model and its kinetic equation is dα/dT=(1/β)CTm(3/2(1-a)2/3[1-(1-α)1/3]-1). At the same time, it has been found that the apparent activation energy E increases with the increases of fraction of conversion α and the absolute temperature T, and then it shows that a linear relationship with the temperature T has been obtained.

  17. KOMPAKT ISI EŞANJÖRLERİNDE KANATÇIK DÜZENLEMELERİNİN BASINÇ KAYBINA ETKİS

    Directory of Open Access Journals (Sweden)

    Yasin VAROL

    2002-01-01

    Full Text Available Bu çalışmada, Kompakt ısı eşanjörlerinde kanatçık kalınlıkları ve kanatçıklar arası mesafe değiştirilerek basınç kayıplarının analizi yapılmıştır. Silindirik koordinatlarda, eksenel simetrik akış için Navier-Stokes denklemleri sonlu farklar yöntemlerinden İmplisit Değişen Yönler Metoduyla çözülmüştür.

  18. Forlægning ved Kolind

    DEFF Research Database (Denmark)

    Steenfelt, Jørgen S.; Thøgersen, Lotte

    I forbindelse med Kalø-Kolind, km 8,2-10,O : Forlægning ved Kolind skal der etableres en vej ud over et blødbundsområde med 3-9 m blødbund. Den nye vej forventes placeret 1,5 á 2,O m over eksisterende terræn og forventes forbelastet med en overhøjde på ca 2 m, svarende til en tillægsspænding Δσ ´1...... materialet fra disse prøverør er der udført 3 konsolideringsforsøg og 2 triaksialforsøg ved Geotekniklaboratoriet på Aalborg Universitet svarende til COWIs beskrivelse i fax dateret 1997- 08-28 og 97-09-23. Datarapport 1 indeholder de bearbejdede resultater fra disse forsøg....

  19. Amfetamin türevleri içeren yasa dışı üretilmiş tabletlerin kromatografik ve spektroskopik yöntemlerle analizleri

    OpenAIRE

    SAİN DÜLGER, Sevda

    2008-01-01

    Bu çalısmada; öncelikle son bes yıl içerisinde değisik illerde yapılan uyusturucuoperasyonlarında ele geçirilen, yasadısı üretilmis çesitli amfetamin grubu maddeiçeren 36 adet ekstazi tabletin renk, logo, ağırlık, çap ve kalınlık gibi fizikselözellikleri belirlendi. Spektroskopik yöntemlerle nitel analizleri ile kromatografikyöntemlerle nicel analizlerinin yapılabilmesi için metot gelistirildi. Kromatografiktekniklerin validasyonu yapıldı ve karsılastırıldı.Uygun çözücü (kloroform ve...

  20. Luminescence excitation characteristics of Ca-, Na- and K-aluminosilicates (feldspars), in the stimulation range 20-500 eV: optical detection of XAS

    CERN Document Server

    Poolton, N R J; Quinn, F M; Pantos, E; Andersen, C E; Bøtter-Jensen, L; Johnsen, O; Murray, A S

    2003-01-01

    We demonstrate that the visible/UV luminescence from common feldspar crystals (NaAlSi sub 3 O sub 8 , KAlSi sub 3 O sub 8 and CaAl sub 2 Si sub 2 O sub 8) can be used to detect detailed L-edge and associated near-edge absorption structure of the main constituent atoms (Ca, K, Na, Al, Si), when exciting in the energy range 20-500 eV. Comparisons of the spectral features are drawn with similar measurements made on the associated materials SiO sub 2 , Al sub 2 O sub 3 and CaCO sub 3. The potential for using optically detected x-ray absorption spectroscopy as a method for identifying the luminescent components of mixed mineral samples is considered.

  1. Three new species of Pergalumna (Acari: Oribatida: Galumnidae) from the tropical rainforest of Veracruz, Mexico.

    Science.gov (United States)

    Palacios-Vargas, José G; Villagomez, Fernando

    2017-03-09

    Three new species of oribatid mites of the genus Pergalumna from a tropical rain forest in Veracruz, Mexico are described. Pergalumna hypergranulosa sp. nov. differs from Pergalumna granulatus Balogh & Mahunka, 1967 by unilaterally barbulated bothridial setae, elongated notogastric porose areas, and also a more profuse granulation of the cerotegument. Pergalumna obsidiana sp. nov. differs from P. granulatus by the unilateral barbulation of bothridial setae and the presence of protuberances on the genital plates; from Pergalumna paralongisetosa Ermilov & Kalúz, 2012 by a diverging cerotegumental granulation on the notogaster. Pergalumna dactylaris sp. nov. differs from Pergalumna striata (Pérez-Íñigo & Baggio, 1980) by its bigger size and the presence of three notogastric porose areas instead of four and from Pergalumna decorata Balogh & Mahunka, 1977, also by the bigger size, a different position of setae lm and la and smaller but not minute interlamellar setae. These are the first Mexican species descriptions of this genus.

  2. Study on Potassium Fluoaluminate Eutectic Flux

    Institute of Scientific and Technical Information of China (English)

    张韻慧; 尹淑梅; 肖莉; 李宁; 张则甡

    2004-01-01

    In this study, Nocolok eutectic flux,used widely in the process of the brazing of aluminum and its alloy, was prepared by the reaction between Al(OH)3/KOH resolution and HF. A series of KF-AlF3 eutectic productions at various reaction temperatures were prepared. The melting points of the products were measured by differential thermal analysis (DTA), and the composites were characterized by X-ray diffraction (XRD). The results suggest that the temperature control is important to produce an ideal flux consisting of K2AlF5, H2O and KAlF4, with a low melting point of 560 ℃,which is suitable for the brazing of aluminum and its alloy as the aluminum fluxes.

  3. LESCH-NYHAN SENDROMU VE 2 OLGU TAKDİMİ- THE LESCH-NYHAN SYNDROME AND REPORT OF TWO CASES

    OpenAIRE

    ERBAY, Elif; ERBAY, Şevket; UĞUR, Türköz

    2013-01-01

    Anahtar Kelimeler : Kalıtımsal ve Metabolik Hastalık, Ürik Asit Miktarının Artması, Zorla Kendi Kendine Zarar Verme,Lesch-Nyhan Sendromu, santral sinir sistemindeki düzensizliklerin belirgin olduğu, purine metabolizmasının bozukluğudur. Sendrom 1964 yılında Micheal Lesch ve William L. Nyhan tarafından tanımlanmıştır.Key Words : The metabolic basis of inherited disease, Hyperuricemia, Self-injurious behavior.The Lesch-Nyhan syndrome is a disorder of purine metabolism in which abnormalities of ...

  4. Low-Energy Polymeric Phases of Alanates

    Science.gov (United States)

    Huan, Tran Doan; Amsler, Maximilian; Marques, Miguel A. L.; Botti, Silvana; Willand, Alexander; Goedecker, Stefan

    2013-03-01

    Low-energy structures of alanates are currently known to be described by patterns of isolated, nearly ideal tetrahedral [AlH4] anions and metal cations. We discover that the novel polymeric motif recently proposed for LiAlH4 plays a dominant role in a series of alanates, including LiAlH4, NaAlH4, KAlH4, Mg(AlH4)2, Ca(AlH4)2, and Sr(AlH4)2. In particular, most of the low-energy structures discovered for the whole series are characterized by networks of corner-sharing [AlH6] octahedra, forming wires and/or planes throughout the materials. Finally, for Mg(AlH4)2 and Sr(AlH4)2, we identify two polymeric phases to be lowest in energy at low temperatures.

  5. Plasminogen activation independent of uPA and tPA maintains wound healing in gene-deficient mice

    DEFF Research Database (Denmark)

    Lund, Leif R; Green, Kirsty A; Stoop, Allart A

    2006-01-01

    Simultaneous ablation of the two known activators of plasminogen (Plg), urokinase-type (uPA) and the tissue-type (tPA), results in a substantial delay in skin wound healing. However, wound closure and epidermal re-epithelialization are significantly less impaired in uPA;tPA double-deficient mice...... than in Plg-deficient mice. Skin wounds in uPA;tPA-deficient mice treated with the broad-spectrum matrix metalloproteinase (MMP) inhibitor galardin (N-[(2R)-2-(hydroxamido-carbonylmethyl)-4-methylpentanoyl]-L-tryptophan methylamide) eventually heal, whereas skin wounds in galardin-treated Plg......-deficient mice do not heal. Furthermore, plasmin is biochemically detectable in wound extracts from uPA;tPA double-deficient mice. In vivo administration of a plasma kallikrein (pKal)-selective form of the serine protease inhibitor ecotin exacerbates the healing impairment of uPA;tPA double-deficient wounds...

  6. Pietro Lupis Valentiano’nun İtalyanca-Türkçe Çeviri Yazılı Sözlüğünde Ses Olayları (1520-1527)

    OpenAIRE

    Yağmur, Ömer

    2015-01-01

    Batı Türkçesinin tarihî gelişimini çoğu zaman Arap harfli imla ile yazılan metinlerden takip etmek güçtür. Türkçe ya da alıntı kelimelerde kalıplaşmış Osmanlı imlasının gölgelediği değişim ve gelişmeler Batılılar tarafından Latin, Kiril, Grek gibi alfabe sistemleri ile yazılan çeviri yazılı metinlerden kolaylıkla takip edilebilmektedir. Bu çalışma erken dönem çeviri yazılı metinlerden biri olan Pietro Lupis Valentiano’nun Opera Nova de M. Pietro Lvpis Valentiano La qual insegna...

  7. Pietro Lupis Valentiano’nun İtalyanca-Türkçe Çeviri Yazılı Sözlüğünde Ses Olayları (1520-1527)

    OpenAIRE

    Yağmur, Ömer

    2016-01-01

    Batı Türkçesinin tarihî gelişimini çoğu zaman Arap harfli imla ile yazılan metinlerden takip etmek güçtür. Türkçe ya da alıntı kelimelerde kalıplaşmış Osmanlı imlasının gölgelediği değişim ve gelişmeler Batılılar tarafından Latin, Kiril, Grek gibi alfabe sistemleri ile yazılan çeviri yazılı metinlerden kolaylıkla takip edilebilmektedir. Bu çalışma erken dönem çeviri yazılı metinlerden biri olan Pietro Lupis Valentiano’nun Opera Nova de M. Pietro Lvpis Valentiano La qual insegna a parlare T...

  8. Thermoluminescence properties of Chile Guajillo (paprika) Mexicano

    Energy Technology Data Exchange (ETDEWEB)

    Kitis, G. [Nuclear Physics Laboratory, Aristotle University of Thessaloniki, Thessaloniki 54124 (Greece)]. E-mail: gkitis@auth.gr; Cruz Zaragoza, E. [Institute of Nuclear Science, UNAM, PO Box 70-753, Mexico DF (Mexico); Furetta, C. [Physics Department, University La Sapienza, P.le A. Moro 2. 00187 Rome (Italy)

    2005-08-01

    The thermoluminescence properties of the inorganic dust extracted from the Chile Guajillo (paprika) Mexicano, were studied in order to verify the possibility of using the TL technique to discriminate between irradiated and non irradiated peppers. The inorganic dust was found to consist of quartz 60%, albite (NaAlSi{sub 3}O{sub 8}) 30%, and ortose (KAlSi{sub 3}O{sub 8}) 10%. Its thermoluminescence dose response covers the wide dose range of 1Gy-10kGy, which was attributed mainly to feldspars. Its high sensitivity and its stability over 10 irradiation-readout cycles allow the application of a single grain-single aliquot regeneration dosimetry in Chile Guajillo (paprika). Evaluations based on trapping parameters show that thermal fading at room temperature for glow-peaks above 180 deg.. C, is not a problem in the dosimetry of paprika.

  9. KARAKTERISASI TEPUNG BUAH LINDUR (Brugeira gymnorrhiza SEBAGAI BERAS ANALOG DENGAN PENAMBAHAN SAGU DAN KITOSAN

    Directory of Open Access Journals (Sweden)

    taufik - hidayat

    2014-06-01

    Full Text Available Penelitian ini bertujuan untuk mengkarakterisasi tepung lindur,menentukan formulasi beras analog, dan karakterisasi produk beras analog terpilih. Penelitian dilakukanmelalui 3 tahap yaitu pembuatan dan karakterisasi tepung buah lindur, formulasi beras analog dan pembuatananalog, serta karakterisasi produk. Hasil penelitian menunjukkan bahwa tepung lindur memiliki karbohidrat(86,10%, tanin (0,21%, amilosa (29,96%, total gula (14,75%, dan HCN (1,98 ppm. Formulasi terbaikadalah kombinasi dari tepung lindur 70% dan tepung sagu 30% dengan penambahan kitosan 0,5%. Berasanalog terpilih memiliki karbohidrat (81,58%, densitas kamba (0,80 g/mL, bobot seribu butir (18,08 g,amilosa 20,36%, serat pangan 8,16%, energi bruto (3.240 kal/g dan daya cerna pati (55,22%.Kata kunci: beras analog, buah lindur, formulasi, kitosan, sagu

  10. Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 Are Identified in Individuals with Congenital Hypogonadotropic Hypogonadism

    DEFF Research Database (Denmark)

    Miraoui, Hichem; Dwyer, Andrew A.; Sykiotis, Gerasimos P.

    2013-01-01

    Congenital hypogonadotropic hypogonadism (CHH) and its anosmia-associated form (Kallmann syndrome [KS]) are genetically heterogeneous. Among the >15 genes implicated in these conditions, mutations in FGF8 and FGFR1 account for ∼12% of cases; notably, KAL1 and HS6ST1 are also involved in FGFR1...... of the so-called “FGF8 synexpression” group and (2) validate the ability of a bioinformatics algorithm on the basis of protein-protein interactome data (interactome-based affiliation scoring [IBAS]) to identify high-quality candidate genes. On the basis of sequence homology, expression, and structural...... and functional data, seven genes were selected and sequenced in 386 unrelated CHH individuals and 155 controls. Except for FGF18 and SPRY2, all other genes were found to be mutated in CHH individuals: FGF17 (n = 3 individuals), IL17RD (n = 8), DUSP6 (n = 5), SPRY4 (n = 14), and FLRT3 (n = 3). Independently, IBAS...

  11. An approach to avascular necrosis by Saghṛta kṣīrabasti

    Directory of Open Access Journals (Sweden)

    Sreelaksmi Chaganti

    2013-01-01

    Full Text Available A 62-year-old, male patient radiologically diagnosed as a case of avascular necrosis of femur head with grade 4, presented the following chief complaints. Pain in the left hip joint radiating to thigh (anterior part, of grade ′9′ on “visual analog scale (VAS” associated with swelling in bilateral feet and decreased range of movements in the hip joint. This presentation was correlated with Asthi-majjagata vāta (musculo-skeletal disorder and treated accordingly. Initially, patient had been administered dīpana and pācana followed by nityavirecana (therapeutic purgation. Further Saghrita kṣīrabasti (medicated enema prepared with milk and ghee was administered in kalābasti schedule (16 in number. This resulted with relief of pain to grade “3” on “VAS” and complete resolution of pedal edema and improvement in range of movement of hip joint.

  12. OLDEST IN THE WORLD MEDIA: LEVEL AND PERCEPTIONS OF ORGANIZATION FUNCTION IN GOSSIP: A FIELD RESEARCH IN HEALTH ORGANIZATION

    Directory of Open Access Journals (Sweden)

    Yücel EROL

    2015-08-01

    Full Text Available Communication in organizations, within the limits specified and configured in accordance with certain rules arising from the formal channels of communication and interpersonal relationships, and are not included in any configuration takes place through informal channels of communication. Known as the world's oldest media rumor and gossip is the size of the informal communication process. Kalınamayan everyday life, away from the gossip and rumors, sometimes complained, but in a way, sometimes including the Red Crescent owned social media. In fact, rumor and gossip is a way of communication. Despite being one of the most common activities in organizations gossip much studied in the literature of the Turkish government issue. Examine this issue, a descriptive framework in order to contribute to the relevant literature is presented. In this study, informal and non-viral rumor that the perception of a means of communication, the functions of individual and organizational point of view, attitudes were assessed on individual merits.

  13. Kalman原理在数据库性能中的应用研究

    Institute of Scientific and Technical Information of China (English)

    高平; 刘竹林

    2012-01-01

    受系统环境的影响和制约,数据库系统在运行过程中性能会慢慢下降,为减小数据库管理员工作盲目性,应用Kalman原理提出预测数据库性能模型。数据库查询划分为三个“静态SQL模型”,介绍kalman(卡尔曼)滤波原理和优化器分析中利用kalman原理预测数据库性能的方法。

  14. Luminescence excitation characteristics of Ca-, Na- and K-aluminosilicates (feldspars), in the stimulation range 20-500 eV: optical detection of XAS

    Energy Technology Data Exchange (ETDEWEB)

    Poolton, N R J [Synchrotron Radiation Department, Daresbury Laboratory, Warrington WA4 4AD, Cheshire (United Kingdom); Malins, A E R [Synchrotron Radiation Department, Daresbury Laboratory, Warrington WA4 4AD, Cheshire (United Kingdom); Quinn, F M [Synchrotron Radiation Department, Daresbury Laboratory, Warrington WA4 4AD, Cheshire (United Kingdom); Pantos, E [Synchrotron Radiation Department, Daresbury Laboratory, Warrington WA4 4AD, Cheshire (United Kingdom); Andersen, C E [Radiation Research Department, Riso National Laboratory, 4000 Roskilde (Denmark); Botter-Jensen, L [Radiation Research Department, Riso National Laboratory, 4000 Roskilde (Denmark); Johnsen, O [Geological Museum, University of Copenhagen, Oster Voldgade 5-7, 1350 Copenhagen (Denmark); Murray, A S [Nordic Laboratory for Luminescence Dating, Aarhus University, Riso National Laboratory, 4000 Roskilde (Denmark)

    2003-05-07

    We demonstrate that the visible/UV luminescence from common feldspar crystals (NaAlSi{sub 3}O{sub 8}, KAlSi{sub 3}O{sub 8} and CaAl{sub 2}Si{sub 2}O{sub 8}) can be used to detect detailed L-edge and associated near-edge absorption structure of the main constituent atoms (Ca, K, Na, Al, Si), when exciting in the energy range 20-500 eV. Comparisons of the spectral features are drawn with similar measurements made on the associated materials SiO{sub 2}, Al{sub 2}O{sub 3} and CaCO{sub 3}. The potential for using optically detected x-ray absorption spectroscopy as a method for identifying the luminescent components of mixed mineral samples is considered.

  15. Synchronous and stochastic oscillations in a nonautonomous transistor oscillator with delayed feedback

    Science.gov (United States)

    Kal'Ianov, E. V.

    1986-11-01

    The stimulation by an external signal of stochastic self-excited oscillations in a nonautonomous transistor oscillator with delayed feedback is investigated experimentally, with a focus on the case of parametric pumping, where the frequency of the external signal is close to the interval between the natural frequencies of the system. The experimental technique and apparatus are similar to those employed by Kal'ianov and Starkov (1985), and the results are presented graphically. Phenomena observed include both (1) enrichment of the oscillation spectrum by excitation of additional, asynchronously interacting modes until a transition to chaos occurs; and (2) parametric suppression of oscillations at certain modes, with phase locking of the mode oscillations and the establishment of synchronous oscillations (i.e., destochastization).

  16. Asset Princes and Wealth Dynamics with Heterogeneous Beliefs - Varlýk Fiyatlarý ve Heterojen Düþünceler ile Servet Dinamikleri

    OpenAIRE

    COGLEY, Timothy; Sargent, Thomas J.; Viktor TSYRENNIKOV

    2015-01-01

    Biz, bu makalede hibeler, öncellerin (priors) ve bilgi akýþlarýnýn özdeþ kalýplarýyla ancak tam piyasalar ve tüketicilerin sadece tekil risksiz tahvillerle iþlem yapabildikleri iki farklý piyasa yapýlarý ile risk piyasa fiyatlarýný karþýlaþtýracaðýz. Makalede spekülasyon fýrsatlarýnýn, olaðandýþý önceki olaylarýn ve öðrenmenin risk piyasa fiyatlarýný nasýl etkilediði incelenmektedir. Ýki tip tüketici, rastgele bir dýþ kaynaklý hibe konusunda devinim yasalarý ile ilgili çeþitli inançlara sahip...

  17. Asset Princes and Wealth Dynamics with Heterogeneous Beliefs [Varlık Fiyatları ve Heterojen Düşünceler ile Servet Dinamikleri

    OpenAIRE

    COGLEY, Timothy; Sargent, Thomas J.; Viktor TSYRENNIKOV

    2015-01-01

    Biz, bu makalede hibeler, öncellerin (priors) ve bilgi akışlarının özdeş kalıplarıyla ancak tam piyasalar ve tüketicilerin sadece tekil risksiz tahvillerle işlem yapabildikleri iki farklı piyasa yapıları ile risk piyasa fiyatlarını karşılaştıracağız. Makalede spekülasyon fırsatlarının, olağandışı önceki olayların ve öğrenmenin risk piyasa fiyatlarını nasıl etkilediği incelenmektedir. İki tip tüketici, rastgele bir dış kaynaklı hibe konusunda devinim yasaları ile ilgili çeşitli inançlara sahip...

  18. PERANAN PEMBELAJARAN MATA KULIAH BAHASA ARAB PADA KEMAMPUAN MENULIS BERBAHASA ARAB BAGI MAHASISWA PROGRAM STUDI PENDIDIKAN BAHASA ARAB (PBA ANGKATAN 2009 JURUSAN TARBIYAH STAIN PEKALONGAN

    Directory of Open Access Journals (Sweden)

    Ali Burhan

    2014-03-01

    Full Text Available This study focused on the role of Arabic teaching in increasing academic writing skill of the students of 2009 who were studying at Arabic Teaching Program of STAIN Pekalongan. The result showed that most of them (60% declared not ready to write their minithesis in Arabic. They were not enough well-prepared in Arabic academic writing. Their grades in overall Arabic subject were 68 in range 0 - 100: starting at General Arabic (Arabic I, II, and III; structure (nahwu and Sharf, pronounciation (Qirâ-ah, listening (Istimâ’, speaking (Kalâm, up to writing skill (kitâbah. It verified that student who had a good grade in a lingual subject, like Arabics, is not equal with his language skill, especially in writing skill.

  19. Pemanfaatan Biji Buah Nyamplung (Callophylum Inophylum Sebagai Bahan Baku Pembuatan Biodisel

    Directory of Open Access Journals (Sweden)

    Bayu Biru Chandra

    2013-03-01

    Full Text Available Indonesia merupakan negara kepulauan dengan garis pantai terpanjang keempat di dunia. Sepanjang sekitar 95000 Km merupakan habitat penting bagi vegetasi mangrove dan biota nya. Sebuah survei tahun 2007 menunjukkan bahwa 20% dari garis pantai rusak, dan tanah aktif terancam oleh erosi. Reboisasi penanaman vegetasi pantai dilakukan oleh pemerintah daerah. Salah satunya adalah Calophyllum Inophyllum. Potensi penggunaan benih C.Inophyllum tidak jelas sampai sekarang. Oleh karena itu, komposisi dan analisia C. Inophyllum dan minyak akan diselidiki. Dari hasil, ditemukan bahwa biji buah C. inophyllum mengandung lemak kasar (63,1%, serat kasar (16,64%, abu (3,22%, protein (3,42%, kelembaban (4,15%, dan ekstrak nitrogen bebas (13.62%. Itu juga memiliki nilai kalori 6092 kal / g. Its lipid asam lemak bebas yang terkandung (8,23%, monogliserida (3,93%, digliserida (3,37%, trigliserida (81.06% dan bioactive (3,4%.

  20. Kalių piometra

    OpenAIRE

    Gentvilaitė, Rasa

    2014-01-01

    Šio darbo uždaviniai įvertinti kalių, sergančių piometra, makšties citologinius ir kraujo parametrų pakitimus. Įvertinti amžiaus įtaką piometros pasireiškimui. Nustatyti laiką po rujos iki piometros klinikinių požymių atsiradimo. Nustatyti mirties atvejus dėl patologijos. Buvo tiriamos trys grupės kalių. I grupė – 16 piometra sergančių patelių. II grupė – 4 kalės, porujo periode, kliniškai sveikos. III grupė 4 – patelės, anestrus periode, kurioms kraujyje nustatyta leukocitozė, bet dėl kitų p...

  1. Ispartada meme kanserli hastalarda BRCA1 ve BRCA2 ekspresyonu

    OpenAIRE

    Çandır, Özden; Karahan, Nermin; Bülbül, Mahmut; Kılınç, Fahriye; Başpınar, Şirin

    2009-01-01

    SüleymanDemirel Üniversitesi TIP FAKÜLTESİ DERGİSİ: 2005 Haziran; 12(2) Ispartada meme kanserli hastalarda BRCA1 ve BRCA2 ekspresyonu Özden Çandır, Nermin Karahan, Mahmut Bülbül, Fahriye Kılınç, Şirin Başpınar, Özet Amaç: BRCA1 ve BRCA2 genlerindeki mutasyonlar, kalıtımsal meme kanserlerinde predispozan faktördür. Sporadik meme kanserlerinde de BRCA proteini ekpresyonunda kayıp olduğu görülmektedir. Bu çalışmada amacımız, Isparta'da meme kanserleri...

  2. Alum as a Catalyst for the Synthesis of Bispyrazole Derivatives

    Directory of Open Access Journals (Sweden)

    Mohammad Ali Zolfigol

    2016-01-01

    Full Text Available Compounds with pyrazolemoieties as nitrogen-containing heterocyclic systems have received attention owing to their diverse biological activities. Alum (KAl(SO42∙12H2O is an inexpensive, reusable and nontoxic catalyst used to synthesize 1H-pyrazole derivatives via the reaction of 3-methyl-1-phenyl-1H-pyrazol-5(4H-one and carbonyl compound under solvent-free conditions at 60 °C. The proposed method has been used for the preparation of 1H-pyrazole derivatives to yield green products for cleaning-in-place and to avoid toxic catalysts and hazardous solvents in accordance with the philosophy of sustainable chemistry.

  3. Temmuz-Ağu. 2010ek

    OpenAIRE

    ,

    2010-01-01

    tutmuştu. Hep aynısını yaşamakta olduğunu düşündü. Koca kupa içindeki çay birkaç yudum aldıktan sonra bir kenarda kalıyor, çay içtiğini, çayının yarım kaldığını fark ettiğinde çayını çoktan buz kesmiş buluyordu. Yine de bir yudum almak istedi yabancı bir markanın Karadeniz Bölgesi çayından

  4. Transcriptome analysis of feline infectious peritonitis virus infection.

    Science.gov (United States)

    Mehrbod, Parvaneh; Harun, Mohammad Syamsul Reza; Shuid, Ahmad Naqib; Omar, Abdul Rahman

    2015-01-01

    Feline infectious peritonitis (FIP) is a lethal systemic disease caused by FIP virus (FIPV). There are no effective vaccines or treatment available, and the virus virulence determinants and pathogenesis are not fully understood. Here, we describe the sequencing of RNA extracted from Crandell Rees Feline Kidney (CRFK) cells infected with FIPV using the Illumina next-generation sequencing approach. Bioinformatics analysis, based on Felis catus 2X annotated shotgun reference genome, using CLC bio Genome Workbench is used to map both control and infected cells. Kal's Z test statistical analysis is used to analyze the differentially expressed genes from the infected CRFK cells. In addition, RT-qPCR analysis is used for further transcriptional profiling of selected genes in infected CRFK cells and Peripheral Blood Mononuclear Cells (PBMCs) from healthy and FIP-diagnosed cats.

  5. Potassium alum and aluminum sulfate micro-inclusions in polar ice from Dome Fuji, East Antarctica

    Science.gov (United States)

    Ohno, Hiroshi; Iizuka, Yoshinori; Horikawa, Shinichiro; Sakurai, Toshimitsu; Hondoh, Takeo; Motoyama, Hideaki

    2014-03-01

    Water-soluble trace constituents affect the physicochemical properties of polar ice. Their structural distribution provides important insights into the formation history of ice and inclusions. We report the first finding of KAl(SO4)2·12H2O (potassium alum) and Al2(SO4)3·nH2O (aluminum sulfate) micro-inclusions in the Dome Fuji ice core, East Antartica, using a micro-Raman technique. Eutectic temperatures of these water-soluble species determined using thermal analysis were -0.4 °C for potassium alum and -8.0 °C for aluminum sulfate. Although the formation process of the aluminum-bearing sulfates remains unclear, the occurrence of these salts largely depends on ice depth.

  6. Ibn Qutayba en al-Andalus. La préface à I 'Adab al-Kātib dans le commentaire d'Ibn al-Sīd al-Baṭalyawsī

    Directory of Open Access Journals (Sweden)

    Soravia, Bruna

    2004-12-01

    Full Text Available Ibn Qutayba's preface to his Adab al-kātib has been considered for centuries the most important section of this work and it has been the object of many commentaries, both in the Muslim East and West. This paper deals with Ibn al-Sīd al-Baṭalyawsī´s commentary al-Iqtiḍāb, trying to show the peculiar way in which Ibn al-Sīd develops his own critique of Ibn Qutayba's controversial thesis on the relation between orthodoxy, falsafa and kalām. At the same time, the Andalusi author works out his own conception of adab, deeply influenced by his biographical experience. Finally a full translation of Ibn Qutayba's preface is proposed, half a century after G. Lecomte's partial one.

    El prefacio de Ibn Qutayba a su Adab al-Kātib ha sido considerado durante siglos como el fragmento más importante de su obra, y ha sido objeto de muchos comentarios, tanto orientales como occidentales. Este artículo trata del comentario que Ibn al-Sīd al-Baṭalyawsī hizo de ese texto de Ibn Qutayba, e intenta mostrar la forma peculiar en que Ibn al-Sīd desarrolla su propia crítica a la polémica tesis de Ibn Qutayba sobre la relación entre ortodoxia, falsafa y kalām. Al mismo tiempo, el autor andalusí elabora su propia concepción del adab, profundamente influida por su experiencia biográfica. Para concluir, se presenta una traducción completa del prefacio de Ibn Qutayba, medio siglo después de la parcial realizada por G. Lecomte.

  7. Endothelial cell permeability during hantavirus infection involves factor XII-dependent increased activation of the kallikrein-kinin system.

    Directory of Open Access Journals (Sweden)

    Shannon L Taylor

    Full Text Available Hemorrhagic fever with renal syndrome (HFRS and hantavirus pulmonary syndrome (HPS are diseases caused by hantavirus infections and are characterized by vascular leakage due to alterations of the endothelial barrier. Hantavirus-infected endothelial cells (EC display no overt cytopathology; consequently, pathogenesis models have focused either on the influx of immune cells and release of cytokines or on increased degradation of the adherens junction protein, vascular endothelial (VE-cadherin, due to hantavirus-mediated hypersensitization of EC to vascular endothelial growth factor (VEGF. To examine endothelial leakage in a relevant in vitro system, we co-cultured endothelial and vascular smooth muscle cells (vSMC to generate capillary blood vessel-like structures. In contrast to results obtained in monolayers of cultured EC, we found that despite viral replication in both cell types as well as the presence of VEGF, infected in vitro vessels neither lost integrity nor displayed evidence of VE-cadherin degradation. Here, we present evidence for a novel mechanism of hantavirus-induced vascular leakage involving activation of the plasma kallikrein-kinin system (KKS. We show that incubation of factor XII (FXII, prekallikrein (PK, and high molecular weight kininogen (HK plasma proteins with hantavirus-infected EC results in increased cleavage of HK, higher enzymatic activities of FXIIa/kallikrein (KAL and increased liberation of bradykinin (BK. Measuring cell permeability in real-time using electric cell-substrate impedance sensing (ECIS, we identified dramatic increases in endothelial cell permeability after KKS activation and liberation of BK. Furthermore, the alterations in permeability could be prevented using inhibitors that directly block BK binding, the activity of FXIIa, or the activity of KAL. Lastly, FXII binding and autoactivation is increased on the surface of hantavirus-infected EC. These data are the first to demonstrate KKS activation

  8. Ring distributions in alkali- and alkaline-earth aluminosilicate framework glasses- a raman spectroscopic study

    Science.gov (United States)

    Sharma, S.K.; Philpotts, J.A.; Matson, D.W.

    1985-01-01

    Raman spectra of crystalline polymorphs of a number of tectosilicate minerals having various sizes of smallest rings of TO4 tetrahedra (T = Si, Al) have been investigated to identify the bands that are sensitive indicators of the smallest rings in the network. The information obtained from the Raman spectra of tectosilicate minerals (e.g., SiO2 polymorphs, NaAlSi3O8 (Ab), NaAlSiO4 (Ne), KAlSi3O8 (Or), and KAlSi2O6 (Lc)) is used to interpret the Raman spectra of the isochemical glasses. It is shown that the frequency of the dominant ??s (TOT) band in the spectra of both crystals and glasses is related to the dominant size of TO4 rings in the structure. In agreement with previous X-ray RDF work, it is found that in the glasses of Ab and Jd (NaAlSi2O6) compositions, six-membered rings of TO4 tetrahedra predominate. The Raman spectrum of Or glass, however, indicates that clusters of intermixed four- and six-membered rings of TO4 tetrahedra, similar to those existing in crystalline leucite, are also present in the glass. Raman evidence indicates that four-membered rings of TO4 tetrahedra predominate in the glass of An composition. Similarly, the higher frequency of the ??s (TOT) band in the spectrum of Ne glass as compared with the frequency the ??s (TOT) band in the spectra of crystalline cargenieite and nephelite indicates either an admixture of the four- and six-membered rings or the puckering of six-membered rings in the glass structure. ?? 1985.

  9. Italian Dermestidae: notes on some species and an updated checklist (Coleoptera).

    Science.gov (United States)

    Nardi, Gianluca; Háva, Jiří

    2013-01-01

    An up-to-date checklist of the Italian Dermestidae is provided. The presence of 95 species in Italy is confirmed, while further 5 species (Dermestes (Dermestes) vorax Motschulsky, 1860, Thorictuspilosus Peyron, 1857, T. wasmanni Reitter, 1895, Attagenus (Attagenus) simonis Reitter, 1881 and Globicornis (G.) breviclavis (Reitter, 1878)) and 1 subspecies (A. (A.) tigrinus pulcher Faldermann, 1835) are excluded from the Italian fauna. Attagenus (Attagenus) calabricus Reitter, 1881 and A. (A.) lobatus Rosenhauer, 1856 are for the first time recorded from Abruzzi and Tuscany respectively; A. (A.) silvaticus Zhantiev, 1976 is recorded for the first time from mainland Italy (Apulia); Anthrenus (Anthrenus) angustefasciatus Ganglbauer, 1904 is new to northern Italy (Friuli-Venezia Giulia), central Italy (Tuscany), Apulia and Basilicata; A. (A.) munroi Hinton, 1943 is new to central Italy (Elba Island); A. (A.) delicatus Kiesenwetter, 1851 is for the first time recorded from Apulia; Globicornis (Globicornis) fasciata (Fairmaire & Brisout de Barneville, 1859) is new to southern Italy (Basilicata); G. (Hadrotoma) sulcata (C.N.F. Brisout de Barneville, 1866) is for the first time recorded from central Italy (Abruzzi), Campania and Sicily, whileTrogoderma inclusum LeConte, 1854 is new to Apulia. Seven species (Dermestes (Dermestes) peruvianus Laporte de Castelnau, 1840, D. (Dermestinus) carnivorus Fabricius, 1775, D. (Dermestinus) hankae Háva, 1999, D. (Dermestinus) intermedius intermedius Kalík, 1951, D. (Dermestinus) szekessyi Kalík, 1950, Anthrenus (Anthrenops) coloratus Reitter, 1881 and Trogodermaangustum (Solier, 1849)) recently recorded from Italy (without further details) are discussed. The lectotype and a paralectotype are designated forAttagenus (A.) calabricus Reitter, 1881 from Calabria. Attagenus pellio (Linnaeus, 1758) var. pilosissimus Roubal, 1932 is removed from synonymy with A. (A.) pellio and recognized as a valid species (stat. prom.); it is known from

  10. Italian Dermestidae: notes on some species and an updated checklist (Coleoptera

    Directory of Open Access Journals (Sweden)

    Gian Luca Nardi

    2013-12-01

    Full Text Available An up-to-date checklist of the Italian Dermestidae is provided. The presence of 95 species in Italy is confirmed, while further 5 species (Dermestes (Dermestes vorax Motschulsky, 1860, Thorictus pilosus Peyron, 1857, T. wasmanni Reitter, 1895, Attagenus (Attagenus simonis Reitter, 1881 and Globicornis (G. breviclavis (Reitter, 1878 and 1 subspecies (A. (A. tigrinus pulcher Faldermann, 1835 are excluded from the Italian fauna.Attagenus (Attagenus calabricus Reitter, 1881 and A. (A. lobatus Rosenhauer, 1856 are for the first time recorded from Abruzzi and Tuscany respectively; A. (A. silvaticus Zhantiev, 1976 is recorded for the first time from mainland Italy (Apulia; Anthrenus (Anthrenus angustefasciatus Ganglbauer, 1904 is new to northern Italy (Friuli-Venezia Giulia, central Italy (Tuscany, Apulia and Basilicata; A. (A. munroi Hinton, 1943 is new to central Italy (Elba Island; A. (A. delicatus Kiesenwetter, 1851 is for the first time recorded from Apulia; Globicornis (Globicornis fasciata (Fairmaire & Brisout de Barneville, 1859 is new to southern Italy (Basilicata; G. (Hadrotoma sulcata (C.N.F. Brisout de Barneville, 1866 is for the first time recorded from central Italy (Abruzzi, Campania and Sicily, while Trogoderma inclusum LeConte, 1854 is new to Apulia.Seven species (Dermestes (Dermestes peruvianus Laporte de Castelnau, 1840, D. (Dermestinus carnivorus Fabricius, 1775, D. (Dermestinus hankae Háva, 1999, D. (Dermestinus intermedius intermedius Kalík, 1951, D. (Dermestinus szekessyi Kalík, 1950, Anthrenus (Anthrenops coloratus Reitter, 1881 and Trogoderma angustum (Solier, 1849 recently recorded from Italy (without further details are discussed.The lectotype and a paralectotype are designated for Attagenus (A. calabricus Reitter, 1881 from Calabria.Attagenus pellio (Linnaeus, 1758 var. pilosissimus Roubal, 1932 is removed from synonymy with A. (A. pellio and recognized as a valid species (stat. prom.; it is known from Lombardy, Apulia

  11. Effects of different catalysts on steam gasification of biomass char at low temperature%不同催化剂对生物质半焦低温气化效果的影响

    Institute of Scientific and Technical Information of China (English)

    俞元元; 肖军; 沈来宏; 杜玉照

    2013-01-01

    study. In which, Al2O3 was used as carrier of the catalyst, and potassium carbonate and sodium carbonate were used as active ingredient, respectively. In addition, the catalyst components were detected by X-ray diffraction analysis (XRD). Using the prepared catalysts, catalytic steam gasification of biomass char was carried out in a lab-scale fluidized bed reactor at the temperature between 600 and 700℃ ℃ to investigate the performance of catalysts. And the effects of catalyst parameters including active ingredient, ingredient contents and calcination temperature, and gasification temperature on the behavior of char gasification were also studied. The results revealed that both potassium based catalyst and sodium based one have significant catalytic action on biomass char conversion. Moreover, potassium based catalyst exhibited better catalytic performance than sodium based one with the same content of active component in rice husk char gasification process. Compared with non-catalytic rice husk char gasification, carbon conversion efficiency was increased by 18.2% and 13.5% using 30KAl(600) and 30NaAl(600), respectively. Increasing K2CO3 content was beneficial to improving char conversion efficiency, and also increasing CO and H2 yield. However the active component contents were inadvisable beyond 30%. The catalyst prepared at different calcination temperature generated the different existing forms of active components. 30KAl(800) catalyst calcinated at 800℃ showed the optimal catalytic action on the char gasification. X-ray diffraction analysis (XRD) showed that the 30KAl(800) catalyst contained K2Al2O2(CO3)2·3H2O, and thus it may be a more effective component. The results showed that both gas yield and carbon conversion efficiency of wheat straw char were higher than those of rice husk char under the same gasification conditions. Thus it also reveals that alkali metal contained in biomass ash has catalytic action on char gasification. The gas yield and carbon

  12. MODELS OF TOURIST DEVELOPMENT IN THE CONTEXT OF REGIONAL DEVELOPMENT

    Directory of Open Access Journals (Sweden)

    Borma Afrodita

    2012-07-01

    Full Text Available Third year PhD candidate at the University of Oradea, under the guidance of Professor Mrs. Alina Bădulescu in the doctoral research project entitled: "Doctoral studies and Ph.D. candidates for competitive research on a knowledge based society", a co-financed project by the European Social Fund through the Sectoral Operational Program for Human Resources Development 2007 - 2013, Priority Axis 1. "Education and training in support for growth and development of a knowledge based society" I chose to present this subject in order to demonstrate the connection that exists between tourism and regional development. Having as research topic "Tourism and development in the Euro regional context” I felt it would be appropriate to devote a subchapter in presenting the impact of tourism in regional development. Thus I have analysed a number of specialised papers found at national and international level in order to achieve a synthesis on the approached topic. Authors such as Williams and Shaw (1991, Sharma (2004, Keskin and Cansiz (2010 were concerned with presenting the positive aspects of tourism in regional development. Condes (2004 presents on one hand the secrets regarding success in matter of tourist development, and on the other side he presents the possible risks that follow the development of tourism in a country / region (Condes 2004. Following the gathered information we found that indeed tourism plays an important role in regional development. The used research methodology consisted in using specialised literature in order to identify some models that illustrate the potential success of tourism in regional development. The space-temporal development model of tourism proposed by Opperman (1993, although it was developed at national level represents a useful tool in illustrating the potential success of tourism in regional development. Miossec's model (Sharma 2004:300 describes the structural evolution of touristic regions in

  13. Development of enteric submicron particle formulation of papain for oral delivery

    Directory of Open Access Journals (Sweden)

    Sharma M

    2011-09-01

    Full Text Available Manu Sharma1, Vinay Sharma2, Amulya K Panda3, Dipak K Majumdar41Department of Pharmacy, Banasthali Vidhyapith, Banasthali, India; 2Department of Bioscience and Biotechnology, Banasthali Vidhyapith, Banasthali, India; 3National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, India; 4Department of Pharmaceutics, Delhi Institute of Pharmaceutical Sciences and Research, University of Delhi, New Delhi, IndiaBackground: Particulate systems have received increasing attention for oral delivery of biomolecules. The objective of the present study was to prepare submicron particulate formulations of papain for pH-dependent site-specific release using pH-sensitive polymers.Methods: Enteric submicron particle formulations of papain were prepared by w/o/w emulsion solvent evaporation using hydroxypropyl methylcellulose phthalate (HPMCP, Eudragit L100, and Eudragit S100, to avoid gastric inactivation of papain.Results: Smaller internal and external aqueous phase volumes provided maximum encapsulation efficiency (75.58%–82.35%, the smallest particle size (665.6–692.4 nm, and 25%–30% loss of enzyme activity. Release studies in 0.1 N HCl confirmed the gastroresistance of the formulations. The anionic submicron particles aggregated in 0.1 N HCl (ie, gastric pH 1.2 due to protonation of carboxylic groups in the enteric polymer. Aggregates < 500 µm size would not impede gastric emptying. However, at pH > 5.0 (duodenal pH, the submicron particles showed deaggregation due to restoration of surface charge. HPMCP submicron particles facilitated almost complete release of papain within 30 minutes at pH 6.0, while Eudragit L100 and Eudragit S100 particles released 88.82% and 53.00% of papain at pH 6.8 and pH 7.4, respectively, according to the Korsmeyer–Peppas equation. Sodium dodecyl sulfate polyacrylamide gel electrophoresis and fluorescence spectroscopy confirmed that the structural integrity of the enzyme was maintained during encapsulation. Fourier

  14. Binary asteroid population. 3. Secondary rotations and elongations

    Science.gov (United States)

    Pravec, P.; Scheirich, P.; Kušnirák, P.; Hornoch, K.; Galád, A.; Naidu, S. P.; Pray, D. P.; Világi, J.; Gajdoš, Š.; Kornoš, L.; Krugly, Yu. N.; Cooney, W. R.; Gross, J.; Terrell, D.; Gaftonyuk, N.; Pollock, J.; Husárik, M.; Chiorny, V.; Stephens, R. D.; Durkee, R.; Reddy, V.; Dyvig, R.; Vraštil, J.; Žižka, J.; Mottola, S.; Hellmich, S.; Oey, J.; Benishek, V.; Kryszczyńska, A.; Higgins, D.; Ries, J.; Marchis, F.; Baek, M.; Macomber, B.; Inasaridze, R.; Kvaratskhelia, O.; Ayvazian, V.; Rumyantsev, V.; Masi, G.; Colas, F.; Lecacheux, J.; Montaigut, R.; Leroy, A.; Brown, P.; Krzeminski, Z.; Molotov, I.; Reichart, D.; Haislip, J.; LaCluyze, A.

    2016-03-01

    We collected data on rotations and elongations of 46 secondaries of binary and triple systems among near-Earth, Mars-crossing and small main belt asteroids. 24 were found or are strongly suspected to be synchronous (in 1:1 spin-orbit resonance), and the other 22, generally on more distant and/or eccentric orbits, were found or are suggested to have asynchronous rotations. For 18 of the synchronous secondaries, we constrained their librational angles, finding that their long axes pointed to within 20° of the primary on most epochs. The observed anti-correlation of secondary synchroneity with orbital eccentricity and the limited librational angles agree with the theories by Ćuk and Nesvorný (Ćuk, M., Nesvorný, D. [2010]. Icarus 207, 732-743) and Naidu and Margot (Naidu, S.P., Margot, J.-L. [2015]. Astron. J. 149, 80). A reason for the asynchronous secondaries being on wider orbits than synchronous ones may be longer tidal circularization time scales at larger semi-major axes. The asynchronous secondaries show relatively fast spins; their rotation periods are typically VH, the secondary rotations are single-periodic with no signs of chaotic rotation and their periods are constant on timescales from weeks to years. The secondary equatorial elongations show an upper limit of a2 /b2 ∼ 1.5 . The lack of synchronous secondaries with greater elongations appears consistent, considering uncertainties of the axis ratio estimates, with the theory by Ćuk and Nesvorný that predicts large regions of chaotic rotation in the phase space for a2 /b2 ≳√{ 2 } . Alternatively, secondaries may not form or stay very elongated in gravitational (tidal) field of the primary. It could be due to the secondary fission mechanism suggested by Jacobson and Scheeres (Jacobson, S.A., Scheeres, D.J. [2011]. Icarus 214, 161-178), as its efficiency is correlated with the secondary elongation. Sharma (Sharma, I. [2014]. Icarus 229, 278-294) found that rubble-pile satellites with a2 /b2 ≲ 1

  15. 重组人组织激肽释放酶结合蛋白的高密度毕赤酵母表达、纯化和生物学活性%Expression of recombinant human kallistatin in Pichia pastoris by high density cell culture, and its purification and characterization

    Institute of Scientific and Technical Information of China (English)

    张倩; 邢永梅; 刘嘉; 刁勇

    2013-01-01

    研究重组人组织激肽释放酶结合蛋白(rHKal)的高密度毕赤酵母表达、纯化以及生物学活性.以质粒pPIC9-Kal/GS1 15 (His4)转化毕赤酵母细胞,在7.5L培养罐内高密度细胞发酵,以1%~2%的甲醇诱导表达rHKal.发酵上清液经疏水层析、亲和层析和凝胶层析分离rHKal.通过MTT及小管形成实验评价rHKal对HUVEC的生物学活性.收获发酵上清液内rHKal的表达水平为50 mg·L-1,纯化后rHKal原液的纯度达98%以上.rHKal对HUVEC的增殖抑制活性呈剂量依赖性,但对其小管形成抑制作用的量效关系呈U型曲线.rHKal 具有新生血管形成抑制活性,本研究为rHKal的生产提供了有效方法.%Kallistatin (Kal) is a negative acute phase endogenous protein which can inhibit tumor angiogenesis,growth and metastasis effectively.To express and purify recombinant human kallistatin (rHKal),and characterize its biological activity,P.pastoris was transformed with pPIC9-Kal/GSll5 (His4) to express rHKal.The fermentation was carried out in a 7.5 L bioreactor with high density cell culture.1%-2% methanol was added to the medium to induce the expression of rHKal.The secretion was purified with phenyl sepharose,G-25 sepharose,heparin sepharose and Sephacryl S-100 chromatography.The biological activity of purified bulk rHKal on HUVEC was evaluated with MTT and tube formation assays.The final expression of rHKal in the supernatant reached 50 mg·L-1,the purity of bulk rHKal after purification was above 98%.A dose-dependent inhibition of rHKal on HUVEC proliferation was observed,however,a U-shaped dose-response curve of rHKal on capillary formation of HUVEC was revealed.The described protocol provides an effective means for preparing rHKal that could be used for anti-angiogenesis therapy in the future.

  16. The Place of Games in Teaching Grammar and Vocabulary Activities (Sample of 5th Grade Textbooks / Oyunların Dil Bilgisi Öğretiminde ve Kelime Serveti Etkinliklerindeki Yeri (Yenilenen İlköğretim 5. Sınıf Ders Kitapları Örneği

    Directory of Open Access Journals (Sweden)

    Mehtap SOLAK SAĞLAM

    2013-12-01

    Full Text Available Turkish Language lesson exists at all levels of elementary curriculum. Grammar education and vocabulary enhancement activities are the most common acquisitions at elementary level. The first part of elementary level is consisted of students aged between 6–11, second part of students between 11–15. Elementary education starting at the age when students are fond of playing games continue until adolescence. These students acquire what they learn through games more easily and keep them in their memories for long. Some activities are organized to this end, and these activities draw attention of students, in turn, the learning process is faster as the attention level of students is quite high. When we study the game samples in Turkish Language textbooks, we will see that they are not adequate. The function of games in teaching grammar and vocabulary enhancement activities should be increased by having new games, so learning will be more efficient and permanent. Türkçe dersi ilköğretimin her kademesinde müfredatta yer alan bir derstir. Dilbilgisi öğretimi ve kelime serveti geliştirme çalışmaları ilköğretim aşamasında en çok karşımıza çıkan kazanımlardır. İlköğretimin birinci kademesi 6–11, ikinci kademesi ise 11–15 yaş arasındaki öğrencileri kapsamaktadır. Oyun çağında başlayan ilköğretim eğitimi gelişme dönemine kadar devam etmektedir. Bu yaş grubundaki öğrenciler, oyunla öğrendiklerini çok daha kısa sürede belleklerine yerleştirmekte ve bu kazanımları çok daha uzun süre hafızalarında tutmaktadırlar. Bu amaçla ilköğretimde bazı etkinlikler bu yönde düzenlenmektedir. Bu etkinlikler öğrencilerin dikkatini çekmekte ve öğrencilerin ilgi düzeyi yüksek olduğu için de öğrenme süreci hızlanmakta, daha kalıcı olmaktadır. Günümüzde okullarda kullanılan Türkçe ders kitaplarında bulunan oyun örnekleri incelenip değerlendirildiğinde oyunların kısıtlı kaldığı g

  17. LATE QUATERNARY EAST ASIAN MONSOONAL EVOLUTION RECORDED BY HIGH RESOLUTION ELEMENTAL RATIOS IN THE NORTHERN SOUTH CHINA SEA%南海北部晚第四纪高分辨率元素比值反映的东亚季风演变

    Institute of Scientific and Technical Information of China (English)

    金海燕; 翦知湣; 谢昕; 田军

    2011-01-01

    选取大洋钻探ODP 184航次在南海北部钻取的1144站(20°3.18'N,117°25.14'E;水深2037m)上部岩芯为研究材料.通过X荧光光谱(XRF)岩芯扫描仪获取晚第四纪100ka以来时间分辨率高达10年的元素记录,并与德国"太阳号"95航次在同一站位获得的17940-2柱状样(20°07.0'N,117°23.0'E;水深1728m)的相关数据(包括底栖有孔虫Uvigerina+Bulimina的丰度、有机碳通量和粘土含量)进行比较,发现Ba/Ti和K/Al比值可以分别反映表层生产力和陆地化学风化的变化,且都具有明显的岁差和半岁差周期,呈现典型的热带气候特征,可能与东亚夏季风的变化有关.特别是,Ba/Ti和K/Al比值还具有类似D/O事件的千年尺度(1.4~2.0ka)周期和与太阳活动相关的百年尺度(约200a和500a)变化周期,且其千年尺度的变化特征在形态上更接近于南极冰芯中的氧同位素记录,反映了低纬海区与南半球高纬区的古气候联系.%The Ocean Drilling Program Site 1144 ( 20°3. 18'N. 117°25. 14'E; water depth 2037m) from the Northern South China Sea was selected for the measurements on elemental contents in deep-sea sediments of the last lOOkaB. P. ,by using a nondestructive X-ray fluorescence ( XRF ) core scanner with an interval of 1cm ( time resolution ca. lOa) . Compared with the relevant data ( benthic foraminifera Uvigerina+Bulimina abundance , organic carbon flux and clay percentage) from Core 17940 -2 ( 20°07. O'N . 117°23. O'E ; water depth 1728m ) recovered during the German SONNE Cruise 95 at almost the same position , our data demonstrated that the elemental ratios such as Ba/Ti and K/Al could be used to indicate the Late Quaternary changes in surface paleoproductivity and chemical weathering ,respectively, and hence to reflect the variations of the East Asian summer monsoon. On the orbital time-scale , the changes of Ba/Ti and K/Al ratios showed remarkable ca. 19. 5ka processional and obvious ca. 10. 9ka semi

  18. Işık ve Optik Konuları ile İlgili Üniversite Öğrencilerinin Kavramsal Anlama Düzeyleri

    Directory of Open Access Journals (Sweden)

    Neşet DEMİRCİ

    2016-06-01

    Full Text Available Bu çalışmanın amacı üniversite öğrencilerinin ışık ve optik konuları ile ilgili kavramsal anlama düzeylerini belirlemektir. Bu çalışma, Türkiye’nin farklı bölgelerinde bulunan dört adet üniversiteden (Balıkesir Üniversitesi, Atatürk Üniversitesi, Dicle Üniversitesi ve Sütçü İmam Üniversitesi toplam 252 kişi ile gerçekleştirilmiştir. Çalışmaya katılan öğrencilerin ışık ve optik konularıyla ilgili kavramsal anlama düzeylerini belirlemek amacıyla; görüntü oluşumu, yansıma, kırılma, ince kenarlı ve kalın kenarlı mercekler, polarizasyon, tek yarıkta kırınım ve çift yarıkta girişim konularını kapsayan optik kavram testi kullanılmıştır. Verilerin analizi sonucunda, üniversite öğrencilerinin ışık ve optik konularında (görüntü oluşumu, yansıma, kırılma, ince kenarlı ve kalın kenarlı mercekler, polarizasyon, tek yarıkta kırınım ve çift yarıkta girişim birçok problemleri olduğu ve öğrencilerin kavramsal anlama düzeylerinin de düşük olduğu tespit edilmiştir. Kavramsal anlama düzeylerinin düşük olmasında öğrencilerin sahip oldukları kavram yanılgılarının büyük etkisinin olduğu düşünülmektedir.

  19. Gana’da bazı topluluklarında elektromanyetik ve elektrik rezistivite yöntemlerle kullunılarak yeraltı su kaynakları araştırması

    Directory of Open Access Journals (Sweden)

    Hafiz Mohammed Nazifi

    2016-08-01

    Full Text Available Gana’ nın merkez bölgesinde bulunan Twifo – Hemang Lower Denkyira ilçesindeki bazı topluluklardan yüksek yeraltı su potansiyeline sahip bölgeleri belirlemek ve belirlenen bu yerler doğrultusunda toplulukların su ihtiyacını karşılayabilecek uygun sondaj yerleri önermek için Elektromanyetik (EM Profili ve Düşey Elektrik Sondajı (DES verileri alınmıştır. Bu çalışmada, sırasıyla Esukese Ekyire, Kwanyarko ve Nyameyeadom kasabalarına ait etüd sonuçları tartışılacaktır. İlk olarak, EM ölçülerin alımı gerçekleştirilmiştir. Daha sonra EM verileri nitelik olarak yorumlanmış ve bunun sonucunda çatlak ve/veya kırık zonları tespit edilmiştir. Schlumberger elektrot dizilimi kullanılarak DES ölçümleri kayaç bozunması gözlenen noktalarda elektromanyetik ölçüm alınan yerlerde yapılmıştır. ZONDIP1D yazılımı, sondaj noktaları altındaki jeolojik yeraltı yapılarının 1D sondaj eğri modellerinin üretilmesinde kullanılmıştır. Modellemenin sonuçları bölgede üç veya dört jeolojik zon bulunduğunu göstermiştir. DES verilerinin 1D ters çözümü yorumlamaları katmanlarının özdirenç ve kalınlık değerlerini vermektedir. Su temini için gerekli olan sondaj kuyu yerleri 1D sondaj eğrisi modeli ve yeraltı katmanlarının kalınlıklarına göre önerilmiştir.

  20. Radiopaque strontium fluoroapatite glass-ceramics

    Directory of Open Access Journals (Sweden)

    Wolfram eHöland

    2015-10-01

    Full Text Available The controlled precipitation of strontium fluoroapatite crystals, was studied in four base glass compositions derived from the SiO2 – Al2O3 – Y2O3 – SrO – Na2O – K2O/Rb2O/Cs2O – P2O5 – F system. The crystal phase formation of these glasses and the main properties of the glass-ceramics, such as thermal and optical properties and radiopacity were compared with a fifth, a reference glass-ceramic. The reference glass-ceramic was characterized as Ca-fluoroapatite glass-ceramic. The four strontium fluoroapatite glass-ceramics showed the following crystal phases: a Sr5(PO43F – leucite, KAlSi2O6 , b Sr5(PO43F – leucite, KAlSi2O6, and nano-sized NaSrPO4 c Sr5(PO43F – pollucite, CsAlSiO4 , and nano-sized NaSrPO4, d Sr5(PO43F – Rb-leucite, RbAlSi2O6, and nano-sized NaSrPO4.The proof of crystal phase formation was possible by X-ray diffraction (XRD. The microstructures, which were studied using scanning electron microscopy (SEM demonstrated a uniform distribution of the crystals in the glass matrix. The Sr-fluoroapatites were precipitated based on an internal crystallization process, and the crystals demonstrated a needlelike morphology. The study of the crystal growth of needlelike Sr-fluoroapatites gave a clear evidence of an Ostwald ripening mechanism.The formation of leucite, pollucite and Rb-leucite was based on a surface crystallization mechanism. Therefore, a twofold crystallization mechanism was successfully applied to develop these types of glass-ceramics. The main focus of this study was the controlled development of glass-ceramics exhibiting high radiopacity in comparison to the reference glass-ceramic. This goal could be achieved with all four glass-ceramics with the preferred development of the Sr-fluoroapatite – pollucite-type glass-ceramic. In addition to this main development, it was possible to control the thermal properties. Especially the Rb-leucite containing glass-ceramic showed the highest coefficient of thermal

  1. Recent and Late Quaternary sedimentation processes in the area of the SE Mediterranean Sea

    Science.gov (United States)

    Hamann, Y.; Ehrmann, W.; Schmiedl, G.; Dulski, P.; Kuhnt, T.

    2007-12-01

    The present distribution of clay minerals in the southeastern Levantine Sea reveals a complex pattern of different source areas and dispersions of the main clay minerals smectite, illite, kaolinite, chlorite, and palygorskite. Smectite dominates the suspension load of the Nile River and rivers of the Near East. Sources of illite are dust- bearing winds blowing from the Saharan desert and the northern mainland of the Levantine Sea. Kaolinite is prevalent in the sediment yield of rivers which drain the Sinai, in sediments of wadis which discharge into the Nile River, and in dust loads of African storms. Palygorskite and chlorite are mainly derived from several dust bearing wind systems of the North and Central African continent, whereas chlorite is also provided by dust-bearing winds of the northeastern Mediterranean mainland. The clay mineral distributions and XRF element data of a sediment core from the southeastern Levantine Sea, spanning the last 27,000 years, show that the sediments are mainly affected by the discharge of the Nile River. The provenance of clay minerals provides a sensitive recorder of changes in the Nile River discharge and therefore in the climate conditions in the catchment of its tributaries. The glacial section of the core is characterized by low smectite concentrations, high K/Al ratios and low linear sedimentation rates when compared to the Holocene suggesting a low influence by the Nile outflow. Subsequently, during the early and middle Holocene, when the North African continent was influenced by more humid conditions during the African Humid Period, our record shows high proportions of smectite and low K/Al ratios which likely reflect higher discharge rates of the River Nile. In contrast to the sharp beginning and end of the African Humid Period as recorded in West African records at 15 and 5.5 kyr BP, our record in the southeastern Levantine Sea shows more transitional patterns and trend towards slightly lower Nile discharge rates at

  2. Lif Takviyeli Plastik Levhalar ile Güçlendirilmiş Betonarme Kirişlerde Arayüz Gerilmelerini Etkileyen Parametreler

    Directory of Open Access Journals (Sweden)

    Barış Sayın

    2010-01-01

    Full Text Available Betonarme kirişlerin, dıştan FRP (Lif Takviyeli Plastik levhalarla güçlendirilmesi, güçlendirmede etkin bir yöntem olarak kabul edilmektedir. Yöntem, FRP malzemesinin, yüksek dayanım-ağırlık oranı, iyi korozyon direnci, farklı kesit şekilleri ve köşelere uygulanabilirlik avantajlarından dolayı kullanılır olmuştur. Konuyla ilgili birçok çalışma 1990'lı yılların başlarından itibaren yürütülmüştür. Gerçekleştirilecek olan çalışma kapsamında, FRP ile güçlendirilen betonarme kirişlerin arayüz gerilmelerini etkileyen parametreler deneysel ve nümerik olarak incelenecektir. FRP'nin kirişe uygulanmasında kullanılan yapıştırıcı kalınlığı, yapıştırıcı türü ve beton yüzeyinin durumu, üretilen deney numuneleri üzerinde eğilme etkisine maruz bırakılarak mukayeseli olarak incelenecektir. Sonrasında, ANSYS® WB sonlu elemanlar programı kullanılarak FRP'li betonarme kirişler modellenecek ve analizler gerçekleştirilecektir. Yapıştırıcı kalınlığı, yapıştırıcı türü, beton yüzeyi parametreleri girilerek yapılacak analizler neticesinde gerilme değerleri elde edilecektir. Böylece, analitik ifadelerde yer alan kayma gerilmesi ve normal gerilme bağıntılarının modifiye edilmesi gerekliliği ortaya konulacaktır. Sonlu eleman analizleri ile deneysel sonuçlar karşılaştırılacak, uyumluluğu irdelenip, sonuçlar ve önerilerin sunulması suretiyle çalışma tamamlanacaktır.

  3. POSSESIVE CONSTRUCTIONS IN AFGHANISTAN TURKMEN TEXTS AFGANİSTAN TÜRKMENCESİ METİNLERİNDEKİ EKSİZ AD TAMLAMALARI

    Directory of Open Access Journals (Sweden)

    Rıdvan ÖZTÜRK

    2010-01-01

    Full Text Available Generally, Afghanistan Turkmen is compatible with Turkmenistan Turkmen. It hasn’t been standardization in literary yet, so it reflects some features its own unique. One of these features is possesive constructions without suffixes. Possesive constructions without suffixes were researched in terms of constituted permanent nouns entitle “goşma noun” (combined noun, compound word in Turkmen language resources. It wasn’t dealed with possesive constructions which did not constitute permanent nouns and was constututed by removing of third person possesive suffix. In this article, it was researched into possesive constructions without suffix determined in Turkmen puplished works in Afghanistan. Afganistan Türkmencesi genel itibariyle Türkmenistan Türkmencesine uygundur. Ancak yazılı geleneğe ve standartlaşmaya henüz geçememiş olması, onun kendisine has bazı sıra dışı özellikleri eselere yansıtmasını sağlamıştır. Bu özelliklerden birisini eksiz ad tamlamaları oluşturmaktadır. Eksiz ad tamlamaları, Türkmence dil bilgisi kaynaklarında “goşma ad” (birleşik ad, birleşik kelime başlığı altında kalıcı adlar oluşturmaları yönü ile incelenmiştir. İyelik üçüncü şahıs ekinin düşürülmesi ile oluşturulan ve kalıcı ad konumuna geçmemiş ad tamlamalarına ise temas edilmemiştir. Bu yazıda, Afganistan Türkmencesi ile yayımlanmış eserlerden tespit ettiğimiz eksiz ad tamlamaları incelenmiştir.

  4. Interaction of chiral rafts in self-assembled colloidal membranes

    Science.gov (United States)

    Xie, Sheng; Hagan, Michael F.; Pelcovits, Robert A.

    2016-03-01

    Colloidal membranes are monolayer assemblies of rodlike particles that capture the long-wavelength properties of lipid bilayer membranes on the colloidal scale. Recent experiments on colloidal membranes formed by chiral rodlike viruses showed that introducing a second species of virus with different length and opposite chirality leads to the formation of rafts—micron-sized domains of one virus species floating in a background of the other viruses [Sharma et al., Nature (London) 513, 77 (2014), 10.1038/nature13694]. In this article we study the interaction of such rafts using liquid crystal elasticity theory. By numerically minimizing the director elastic free energy, we predict the tilt angle profile for both a single raft and two rafts in a background membrane, and the interaction between two rafts as a function of their separation. We find that the chiral penetration depth in the background membrane sets the scale for the range of the interaction. We compare our results with the experimental data and find good agreement for the strength and range of the interaction. Unlike the experiments, however, we do not observe a complete collapse of the data when rescaled by the tilt angle at the raft edge.

  5. A Comparative Study of Patriotism, Protectionism, Social Economic Conservatism between Indian and Vietnamese Consumers: The Effects of these Constructs on Buying Inclinations

    Directory of Open Access Journals (Sweden)

    John E. SPILLAN

    2013-11-01

    Full Text Available The current study’s emphasis is intended to provide researchers with a point of departure for understanding specific cultural differences associated with the ethnocentrism scale. Consumer characteristics such as patriotism, protectionism and social economic conservatism are analyzed. This manuscript empirically compares these three dimensions of the ethnocentrism scale (Shimp, T. A. and Sharma, S. 1987 using data furnished by Vietnamese and Indian consumers. Using confirmatory factor analysis (CFA, the findings indicate that the three dimensions of the ethnocentrism model are validated in both countries. The study results indicated that there are discernable attitudinal differences between Vietnamese and Indian consumers. The study also explores the relationship between CETSCALE subscales (patriotism, protectionism and social economic conservatism of Vietnamese and Indian consumers and the underlying dimensions of ethnocentrism construct with different countries. The results showed that all loadings in the model were significant, leading us to conclude that the relationships between the items and latent factors were confirmed by the two datasets obtained from different countries.

  6. Raman spectroscopy measurements of the vibrational properties of uv-polymerized C60 thin film and C60 powder compressed in a diamond anvil cell

    Science.gov (United States)

    Li, Y.; Singh, D.; Sharma, S. C.

    2002-03-01

    We present results from a series of experiments designed to further study the effects of pressure on the vibrational properties of C60 compressed under high pressures (10 GPa) in a diamond anvil cell. The Raman scattering measurements were made by using a high resolution optical spectrometer that consists of a 1.25 m, f/11 monochromator, 2400 g/mm, ion-etched blazed holographic diffraction grating, 2048x512 pixel back illuminated liquid nitrogen cooled CCD camera, Super-Notch-Plus filter, argon-ion laser operating at 514.5 nm, and SpectraMax for Windows software. The Raman scattering measurements on C60 thin films show a large ( 10 cm-1) and characteristic red shift in the pentagonal pinch mode Ag(2) of pristine C60 upon irradiation by 21.2 eV photons. Upon heating this film under 10(-3) Torr vacuum at 413 and 473 K, the Raman spectra shift towards the pentagonal pinch mode of pristine C60. These results are in agreement with previously published data (1,2) and they show that the film is polymerized because of uv irradiation. We have also measured spectra for C60 powder compressed under high pressures in a diamond anvil cell. We present results for several frequencies of the Raman active modes of C60. 1. A. M. Rao et al, Science 259, 955 (1993); 2. S. C. Sharma et al, Mat. Res. Symp. Proc. 695, L3.10 (2002)

  7. Max-Sum Diversification, Monotone Submodular Functions and Dynamic Updates

    CERN Document Server

    Borodin, Allan; Ye, Yuli

    2012-01-01

    Result diversification has many important applications in databases, operations research, information retrieval, and finance. In this paper, we study and extend a particular version of result diversification, known as max-sum diversification. More specifically, we consider the setting where we are given a set of elements in a metric space and a set valuation function $f$ defined on every subset. For any given subset $S$, the overall objective is a linear combination of $f(S)$ and the sum of the distances induced by $S$. The goal is to find a subset $S$ satisfying some constraints that maximizes the overall objective. This problem is first studied by Gollapudi and Sharma for modular set functions and for sets satisfying a cardinality constraint. We consider an extension of the modular case to the monotone submodular case, for which the previous algorithm no longer applies. Interestingly, we are able to match the 2-approximation using a natural, but different greedy algorithm. We then further extend the problem...

  8. Targeting the androgen receptor in triple-negative breast cancer: current perspectives

    Directory of Open Access Journals (Sweden)

    Mina A

    2017-09-01

    Full Text Available Alain Mina,1 Rachel Yoder,2 Priyanka Sharma1 1Division of Medical Oncology, Department of Internal Medicine, University of Kansas Medical Center, Westwood, 2University of Kansas Cancer Center, Kansas City, KS, USA Abstract: Triple-negative breast cancer (TNBC is an aggressive subtype associated with frequent recurrence and metastasis. Unlike hormone receptor-positive subtypes, treatment of TNBC is currently limited by the lack of clinically available targeted therapies. Androgen signaling is necessary for normal breast development, and its dysregulation has been implicated in breast tumorigenesis. In recent years, gene expression studies have identified a subset of TNBC that is enriched for androgen receptor (AR signaling. Interference with androgen signaling in TNBC is promising, and AR-inhibiting drugs have shown antitumorigenic activity in preclinical and proof of concept clinical studies. Recent advances in our understanding of androgenic signaling in TNBC, along with the identification of interacting pathways, are allowing development of the next generation of clinical trials with AR inhibitors. As novel AR-targeting agents are developed and evaluated in clinical trials, it is equally important to establish a robust set of biomarkers for identification of TNBC tumors that are most likely to respond to AR inhibition. Keywords: triple-negative breast cancer, androgen signaling, targeted therapy, biomarkers, prognosis 

  9. Effect of turbulence models on predicting convective heat transfer to hydrocarbon fuel at supercritical pressure

    Institute of Scientific and Technical Information of China (English)

    Tao Zhi; Cheng Zeyuan; Zhu Jianqin; Li Haiwang

    2016-01-01

    A variety of turbulence models were used to perform numerical simulations of heat transfer for hydrocarbon fuel flowing upward and downward through uniformly heated vertical pipes at supercritical pressure. Inlet temperatures varied from 373 K to 663 K, with heat flux rang-ing from 300 kW/m2 to 550 kW/m2. Comparative analyses between predicted and experimental results were used to evaluate the ability of turbulence models to respond to variable thermophys-ical properties of hydrocarbon fuel at supercritical pressure. It was found that the prediction per-formance of turbulence models is mainly determined by the damping function, which enables them to respond differently to local flow conditions. Although prediction accuracy for experimental results varied from condition to condition, the shear stress transport (SST) and launder and sharma models performed better than all other models used in the study. For very small buoyancy-influenced runs, the thermal-induced acceleration due to variations in density lead to the impairment of heat transfer occurring in the vicinity of pseudo-critical points, and heat transfer was enhanced at higher temperatures through the combined action of four thermophysical properties: density, viscosity, thermal conductivity and specific heat. For very large buoyancy-influenced runs, the thermal-induced acceleration effect was over predicted by the LS and AB models.

  10. The role of cell transplantation in modifying the course of limb girdle muscular dystrophy: a longitudinal 5-year study

    Directory of Open Access Journals (Sweden)

    Sharma A

    2015-09-01

    Full Text Available Alok Sharma,1 Hemangi Sane,2 Nandini Gokulchandran,1 Sushant Gandhi,3 Pradnya Bhovad,3 Dipti Khopkar,2 Amruta Paranjape,2 Khushboo Bhagwanani,3 Prerna Badhe1 1Department of Medical Services and Clinical Research, 2Department of Research and Development, 3Department of Neurorehabilitation, NeuroGen Brain and Spine Institute, Stemasia Hospital and Research Centre, Nerul, Navi Mumbai, Maharashtra, India Abstract: Limb girdle muscular dystrophy (LGMD, a group of progressive degenerative disorders, causes functional limitation affecting the quality of life. Cell therapy is being widely explored and preliminary studies have shown beneficial effects. Cell therapy induces trophic-factors release, angiogenesis, anti-inflammation, and protein synthesis, which helps in the reparative process at the microcellular level. In this 5-year longitudinal study, the effect of autologous bone marrow mononuclear cells is studied on the natural course of 65 patients with LGMD. Functional Independence Measure and manual muscle testing showed statistically significant improvement, post-cell transplantation. The key finding of this study was demonstration of a plateau phase in the disease progression of the patients. No adverse events were noted. Autologous bone marrow mononuclear cells may be a novel, safe, and effective treatment approach to control the rate of progression of LGMD, thus improving the functional outcomes. Further randomized controlled trials are required. Keywords: cell therapy, autologous, bone marrow

  11. Industrial application of the decomposition of CO2 . NOx by large flow atmospheric microwave plasma LAMP employed in motorcar

    Science.gov (United States)

    Pandey, Anil; Niwa, Syunta; Morii, Yoshinari; Ikezawa, Shunjiro

    2012-10-01

    In order to decompose CO2 . NOx [1], we have developed the large flow atmospheric microwave plasma; LAMP [2]. It is very important to apply it for industrial innovation, so we have studied to apply the LAMP into motorcar. The characteristics of the developed LAMP are that the price is cheap and the decomposition efficiencies of CO2 . NOx are high. The mechanism was shown as the vertical configuration between the exhaust gas pipe and the waveguide was suitable [2]. The system was set up in the car body with a battery and an inverter. The battery is common between the engine and the inverter. In the application of motorcar, the flow is large, so the LAMP which has the merits of large flow, high efficient decomposition, and cheap apparatus will be superior.[4pt] [1] H. Barankova, L. Bardos, ISSP 2011, Kyoto.[0pt] [2] S. Ikezawa, S. Parajulee, S. Sharma, A. Pandey, ISSP 2011, Kyoto (2011) pp. 28-31; S. Ikezawa, S. Niwa, Y. Morii, JJAP meeting 2012, March 16, Waseda U. (2012).

  12. Minnesota Multiphasic Personality Inventory-2-Restructured Form (MMPI-2-RF) normative elevation rates: comparisons with epidemiological prevalence rates.

    Science.gov (United States)

    Tarescavage, Anthony M; Marek, Ryan J; Finn, Jacob A; Hicks, Adam; Rapier, Jessica L; Ben-Porath, Yossef S

    2013-01-01

    Odland, Berthelson, Sharma, Martin, and Mittenberg ( 2013 ) caution that clinically elevated scale scores produced by members of the Minnesota Multiphasic Personality Inventory-2-Restructured Form (MMPI-2-RF; Ben-Porath & Tellegen, 2008 /2011) normative sample raise concerns about the potential for false positive findings of psychopathology. However, the MMPI-2-RF normative sample is intended to represent the general population of the United States, 26.2% of which met criteria for a Diagnostic and Statistical Manual-IV (APA, 1994 ) disorder in a 12-month period (Kessler, Chiu, Demler, & Walters, 2005 ). In the current study we compare scale elevation rates in the MMPI-2-RF normative sample to prevalence rates of mental disorders primarily drawn from the National Comorbidity Study Replication (Kessler et al., 2005 ). Our objective was to evaluate MMPI-2-RF elevation rates in an epidemiological context. Results indicate that MMPI-2-RF scale elevation rates were generally consistent with epidemiological data when examined in the context of standard interpretation guidelines for the inventory. We also reiterate Ben-Porath and Tellegen's (2008/2011) caution that MMPI-2-RF scale elevations alone are not sufficient to indicate the presence of psychiatric disorder. Rather they are best viewed as indications of the need to evaluate the individual for possible disorder(s). Implications of these results, limitations of this study, and future directions in research are discussed.

  13. Some Results of Fixed Points in Generalized Metric Space by Methods of Suzuki and Samet

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    Hojjat Afshari

    2015-08-01

    Full Text Available In 1992 Dhage introduced the notion of generalized metric or D-metric spaces and claimed that D-metric convergence define a Hausdorff topology and that $D$-metric is sequentially continuous in all the three variables. Many authors have taken these claims for granted and used them in proving fixed point theorems in $D$-metric spaces. In 1996 Rhoades generalized Dhages contractive condition by increasing the number of factors and proved the existence of unique fixed point of a self map in $D$-metric space. Recently motivated by the concept of compatibility for metric space. In 2002 Sing and Sharma introduced the concept of $D$-compatibility of maps in $D$-metric space and proved some fixed point theorems using a contractive condition. In this paper ,we prove some fixed point theorems and common fixed point theorems in $D^*$-complete metric spaces under particular conditions among weak compatibility. Also by Using method of Suzuki and Samet we prove some theorems in generalised metric spaces.

  14. Numerical and experimental investigations on the heat transfer enhancement in corrugated channels using SiO2–water nanofluid

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    M.A. Ahmed

    2015-09-01

    Full Text Available In this paper, convective heat transfer of SiO2–water nanofluid flow in channels with different shapes is numerically and experimentally studied over Reynolds number ranges of 400–4000. Three different channels such as trapezoidal, sinusoidal and straight were fabricated and tested. The SiO2–water nanofluid with different volume fractions of 0%, 0.5% and 1.0% were prepared and examined. All physical properties of nanofluid which are required to evaluate the flow and thermal characteristics have been measured. In the numerical aspect of the current work, the governing equations are discretized by using the collocated finite volume method and solved iteratively by using the SIMPLE algorithm. In addition, the low Reynolds number k–ε model of Launder and Sharma is employed to compute the turbulent non-isothermal flow in the present study. The results showed that the average Nusselt number and the heat transfer enhancement increase as the nanoparticles volume fraction increases, however, at the expense of increasing pressure drop. Furthermore, the trapezoidal-corrugated channel has the highest heat transfer enhancement followed by the sinusoidal-corrugated channel and straight channel. The numerical results are compared with the corresponding experimental data, and the results are in a good agreement.

  15. Translation by polysome: theory of ribosome profile on a single mRNA transcript

    CERN Document Server

    Sharma, Ajeet K

    2011-01-01

    The process of polymerizing a protein by a ribosome, using a messenger RNA (mRNA) as the corresponding template, is called {\\it translation}. Ribosome may be regarded as a molecular motor for which the mRNA template serves also as the track. Often several ribosomes may translate the same (mRNA) simultaneously. The ribosomes bound simultaneously to a single mRNA transcript are the members of a polyribosome (or, simply, {\\it polysome}). Experimentally measured {\\it polysome profile} gives the distribution of polysome {\\it sizes}. Recently a breakthrough in determining the instantaneous {\\it positions} of the ribosomes on a given mRNA track has been achieved and the technique is called {\\it ribosome profiling} \\cite{ingolia10,guo10}. Motivated by the success of these techniques, we have studied the spatio-temporal organization of ribosomes by extending a theoretical model that we have reported elsewhere \\cite{sharma11}. This extended version of our model incorporates not only (i) mechano-chemical cycle of indivi...

  16. Kinetic Study of Esterification of Acetic Acid with n-butanol and isobutanol Catalyzed by Ion Exchange Resin

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    Amrit Pal Toor

    2011-05-01

    Full Text Available Esters are an important pharmaceutical intermediates and very useful perfumery agents. In this study the esterification of acetic acid with n-butanol and iso-butanol over an acidic cation exchange resin, Amberlyst 15 were carried out. The effects of certain parameters such as temperature, catalyst loading, initial molar ratio between reactants on the rate of reaction were studied. The experiments were conducted in a stirred batch reactor in the temperature range of 351.15 K to 366.15K.Variation of parameters on rate of reaction demonstrated that the reaction was intrinsically controlled.The activation energy for the esterification of acetic acid with n-butanol and iso butanol is found to be 28.45 k J/mol and 23.29 kJ/mol respectively. ©2011 BCREC UNDIP. All rights reserved.(Received: 16th December 2010, Revised: 19th March 2011; Accepted: 7th April 2011[How to Cite: A.P. Toor, M. Sharma, G. Kumar, and R. K. Wanchoo. (2011. Kinetic Study of Esterification of Acetic Acid with n-butanol and isobutanol Catalyzed by Ion Exchange Resin. Bulletin of Chemical Reaction Engineering and Catalysis, 6(1: 23-30. doi:10.9767/bcrec.6.1.665.23-30][How to Link / DOI: http://dx.doi.org/10.9767/bcrec.6.1.665.23-30 || or local: http://ejournal.undip.ac.id/index.php/bcrec/article/view/665 ] | View in 

  17. Ceria-Based Mixed Oxide Supported Nano-Gold as an Efficient and Durable Heterogeneous Catalyst for Oxidative Dehydrogenation of Amines to Imines Using Molecular Oxygen

    Directory of Open Access Journals (Sweden)

    Bashir Ahmad Dar

    2012-06-01

    Full Text Available The present work is intended to determine the catalytic activity of Mixed Oxide supported gold for aerobic oxidative dehydrogenation of amines to imines using Ceria as a main constituent of the each support. The model catalysts Au/CeO2:TiO2 Au/CeO2:SiO2, Au/CeO2:ZrO2 and Au/CeO2:Al2Os were prepared by deposition co-precipitation method and deposition of gold was determined by EDEX analysis. The supported nano-gold catalyzes the dehydrogenation of secondary amines to imines without loss of activity. On recycling good amount of product yield is obtained. Oxidation of secondary amines to imines is carried at 100˚C and almost 90 % conversion was obtained with >99% selectivity. © 2012 BCREC UNDIP. All rights reservedReceived: 26th December 2011; Revised: 7th June 2012; Accepted: 13rd June 2012[How to Cite: B.A. Dar, M. Sharma, B. Singh. (2012. Ceria-Based Mixed Oxide Supported Nano-Gold as an Efficient and Durable Heterogeneous Catalyst for Oxidative Dehydrogenation of Amines to Imines Using Molecular Oxygen. Bulletin of Chemical Reaction Engineering & Catalysis, 7(1: 79-84.  doi:10.9767/bcrec.7.1.1257.79-84][How to Link / DOI: http://dx.doi.org/10.9767/bcrec.7.1.1257.79-84 ] | View in 

  18. Book Review ~ Supporting Students in Open and Distance Learning. Author: Ormond Simpson

    Directory of Open Access Journals (Sweden)

    Reviewed by Ramesh C. Sharma

    2002-04-01

    Full Text Available The Open and Distance Learning (ODL system has come a long way, emerging as an acceptable mode of extending the outreach of educational opportunities globally, ranging from China with the world’s largest population to Tuvalu with a population of only 11,000. In terms of geographic area, Sharma (1997 reported that ODL institutions are operating in countries large and small, the largest being Russia, to Israel, one of the smallest. In terms of population, Costa Rica boasts of one of the smallest populations served by ODL, whereas China’s ODL system undoubtedly serves the largest. Owing to the diverse nature of demographic variables in terms of placement, job, socio-economic conditions, open university students often find it inconvenient to be physically present in a classroom setting for face-to-face instruction at stipulated times and places. However, to help overcome barriers of time and space, students studying using the distance mode, nonetheless require periodic guidance as well as counseling on academic and non-academic matters. In addition to print materials, students also require administrative, academic and library support services. Quite simply, effective student support helps to increase student retention (Brindley, 1985; Hara and Kling, 1999 and is clearly an indicator of success for any educational institution.

  19. Thrombocytopenia absent radius syndrome with Tetralogy of Fallot: a rare association

    Directory of Open Access Journals (Sweden)

    Kumar C

    2015-03-01

    Full Text Available Chetan Kumar,1 Deepak Sharma,2 Aakash Pandita,2 Sanjay Bhalerao1 1Department of Pediatrics, Madras Institute of Orthopedic and Trauma, Manapakkam, Chennai, India; 2Department of Neonatology, Fernandez Hospital, Hyderabad, India Abstract: Thrombocytopenia absent radius (TAR syndrome is a very rare and infrequently seen congenital disorder with an approximate frequency of 0.42/100,000 live births. It is associated with bilateral absence of radii, hypo-megakaryocytic thrombocytopenia, and presence of both thumbs. The other systems which are affected by TAR syndrome include skeletal, hematologic, and cardiac systems. Intracranial hemorrhages due to thrombocytopenia and cardiac disorders are a common association usually seen with this syndrome and are usual cause of death. We describe a 3-month-old infant who was diagnosed with TAR syndrome on the basis of clinical features (thrombocytopenia and bilateral absent radius bone and confirmed by genetic analysis. The patient was diagnosed to have Tetralogy of Fallot, for which the infant was managed with definitive repair and thrombocytopenia was managed with platelet transfusion. Infants with TAR syndrome should be assessed for other associated malformations of various systems and followed up regularly and parents should be counseled for associated expected complications in these patients. We report an infant with TAR syndrome with Tetralogy of Fallot, which has not been reported in medical literature until now and this is the first case of its type. Keywords: thrombocytopenia absent radius syndrome, Tetralogy of Fallot, microdeletion 1q21.1, RBM8A

  20. Optical-bistability-enabled control of resonant light transmission for an atom-cavity system

    Science.gov (United States)

    Sawant, Rahul; Rangwala, S. A.

    2016-02-01

    The control of light transmission through a standing-wave Fabry-Pérot cavity containing atoms is theoretically and numerically investigated, when the cavity mode beam and an intersecting control beam are both close to specific atomic resonances. A four-level atomic system is considered and its interaction with the cavity mode is studied by solving for the cavity field and atomic state populations. The conditions for optical bistability of the atom-cavity system are obtained. The response of the intracavity intensity to an intersecting beam on atomic resonance is understood in the presence of stationary atoms (closed system) and nonstatic atoms (open system) in the cavity. The nonstatic system of atoms is modelled by adjusting the atomic state populations to represent the exchange of atoms in the cavity mode, which corresponds to a thermal environment where atoms are moving in and out of the cavity mode volume. The control behavior with three- and two-level atomic systems is also studied, and the rich physics arising out of these systems for closed and open atomic systems is discussed. The solutions to the models are used to interpret the steady-state and transient behavior observed by Sharma et al. [Phys. Rev. A 91, 043824 (2015)], 10.1103/PhysRevA.91.043824.

  1. Optical bistability enabled control of resonant light transmission for an atom-cavity system

    CERN Document Server

    Sawant, Rahul

    2015-01-01

    The control of light transmission through a Fabry-Perot cavity containing atoms is theoretically investigated, when the cavity mode beam and an intersecting control beam are both close to specific atomic resonances. A four-level atomic system is considered and its interaction with the cavity mode is studied by solving for the time dependent cavity field and atomic state populations. The conditions for optical bistability of the atom-cavity system are obtained in steady state limit. For an ensemble of atoms in the cavity mode, the response of the intra-cavity light intensity to the intersecting resonant beam is understood for stationary atoms (closed system) and non-static atoms (open system). The open system is modelled by adjusting the atomic state populations to represent the exchange of atoms in the cavity mode, with the thermal environment. The solutions to the model are used to qualitatively explain the observed steady state and transient behaviour of the light in the cavity mode, in Sharma et. al. [1]. ...

  2. Quality of life among people living with acquired immune deficiency syndrome receiving anti-retroviral therapy: a study from Nepal

    Directory of Open Access Journals (Sweden)

    Giri S

    2013-09-01

    Full Text Available Smith Giri, Maniraj Neupane, Sushil Pant, Utsav Timalsina, Sagar Koirala, Santosh Timalsina, Sashi Sharma Department of Medicine, Tribhuvan University Teaching Hospital, Kathmandu, Nepal Purpose: The present study was undertaken to determine the impact of acquired immune deficiency syndrome (AIDS on the quality of life of affected individuals in Nepal. Patients and methods: A cross sectional study was done among 70 individuals attending the Anti-Retroviral Therapy clinic of the University Hospital in Nepal. Quality of life (QOL was evaluated using World Health Organization Quality of life questionnaire (WHO QOL-BREF instrument. Statistical analysis was done using SPSS Version 17.0. Results: The median scores with interquartile range (IQR in four domains of QOL in descending order were physical (61; IQR 22, social (58; IQR 33, environmental (56; IQR 13, and psychological (54; IQR 8. Older age was associated with lower perceived overall QOL. Females were more likely to have lower QOL scores in the social and psychological domains. Higher CD4 counts and a married status were significant predictors of higher QOL scores in the environmental domain. Conclusion: Being older, female, single, and having advanced clinical stage is associated with lower QOL scores in people living with AIDS. Lowest QOL scores were seen in the psychological domain suggesting the need of psychological interventions. Keywords: quality of life, AIDS, Nepal, WHO QOL-BREF

  3. Influence of Delhi Pollution on Aerosol Properties Over Greater Noida

    Science.gov (United States)

    Sharma, M.; Singh, R. P.; Kumar, R.

    2015-12-01

    Influence of Delhi Pollution on Aerosol Properties over Greater NoidaManish Sharma1, Ramesh P. Singh2 and Rajesh Kumar3 1Research and Technology Development Centre, Sharda University, Greater Noida, India. 2School of Earth and Environmental Sciences, Schmid College of Science, Chapman University, Orange 92866, USA 3School of Basic Sciences and Research, Sharda University, Greater Noida, India. Delhi capital of India is highly polluted during winter and summer seasons. Due to dominant westerly winds the air mass influence its neighboring city Greater Noida which is located 60 km south east of Delhi. Detailed analysis of multi satellite data and ground observations have been carried out during 2001-2015. The ground observation and satellite data show dynamic aerosol optical parameters over Greater Noida. During winter and summer seasons, dominant westerly wind outflow pollutants of Delhi that mix with the local anthropogenic emissions of Greater Noida influencing aerosol properties at different pressure levels. The characteristics of trace gases and aerosol parameters over Delhi and Greater Noida will be presented. The air quality is severely affected from the outflow of pollutants from Delhi which is threat to people living in the area. Due to dominant winds the air mass further transported towards eastern parts of Indo-Gangetic plains affecting weather conditions of the major cities.

  4. Focused ion beams using a high-brightness plasma source

    Science.gov (United States)

    Guharay, Samar

    2002-10-01

    High-brightness ion beams, with low energy spread, have merits for many new applications in microelectronics, materials science, and biology. Negative ions are especially attractive for the applications that involve beam-solid interactions. When negative ions strike a surface, especially an electrically isolated surface, the surface charging voltage is limited to few volts [1]. This property can be effectively utilized to circumvent problems due to surface charging, such as device damage and beam defocusing. A compact plasma source, with the capability to deliver either positive or negative ion beams, has been developed. H- beams from this pulsed source showed brightness within an order of magnitude of the value for beams from liquid-metal ion sources. The beam angular intensity is > 40 mAsr-1 and the corresponding energy spread is 1 Acm-2 and a spot size of 100 nm. Such characteristics of focused beam parameters, using a dc source, will immediately open up a large area of new applications. [1] P. N. Guzdar, A. S. Sharma, S. K. Guharay, "Charging of substrates irradiated by particle beams" Appl. Phys. Lett. 71, 3302 (1997). [2] S. K. Guharay, E. Sokolovsky, J. Orloff, "Characteristics of ion beams from a Penning source for focused ion beam applications" J. Vac. Sci Technol. B17, 2779 (1999).

  5. Phase relations of triadic scale interactions in turbulent flows

    Science.gov (United States)

    Duvvuri, Subrahmanyam; McKeon, Beverley

    2014-11-01

    The quadratic nature of non-linearity in the Navier-Stokes (NS) equations dictates the coupling between scales in a turbulent flow to be of triadic form. An understanding of the triadic coupling affords good insights into the dynamics of turbulence, as demonstrated by Sharma & McKeon (J. Fluid Mech., 2013) through analysis of the NS resolvent operator; a set of three triadically consistent spatio-temporal modes was shown to produce complex structures such as modulating packets of hairpin vortices observed in wall-bounded turbulent flows. Here we interpret Skewness (Sk) of velocity fluctuations and the Amplitude Modulation coefficient (Ram), proposed by Mathis, Hutchins & Marusic (J. Fluid Mech., 2009), to be a measure of the large- and small-scale phase relationship. Through a simple decomposition of scales, both Sk and Ram are shown to be amplitude weighted (and normalized) measures of phase between scales that have direct triadic coupling. An analytical relationship is established between the two quantities and the result is demonstrated using experimental data from canonical and dynamically forced turbulent boundary layers presented in Duvvuri and McKeon (AIAA 2014-2883). The support of AFOSR (Grant No. FA 9550-12-1-0469) and Resnick Institute Graduate Research Fellowship (S.D.) is gratefully acknowledged.

  6. Reynolds shear stress near its maxima, turbulent bursting process and associated velocity profle in a turbulent boundary layer

    Science.gov (United States)

    Afzal, Noor

    2014-11-01

    The Reynolds shear stress around maxima, turbulent bursting process and associate velocity profile in ZGP turbulent boundary layer is considered in the intermediate layer/mesolayer proposed by Afzal (1982 Ing. Arch. 53, 355-277), in addition to inner and outer layers. The intermediate length scale δm = δRτ- 1 / 2 having velocity Um = mUe with 1 / 2 AIAA J). For channel/pipe flow, Sreenivasan et al. (1981989, 1997, 2006a,b) proposed critical layer / mesolayer, cited/adopted work Long and Chen and McKeon, B.J. & Sharma, A. 2010 JFM 658, page 370 stated ``retaining the assumption that the critical layer occurs when U (y) = (2 / 3) UCL (i.e. that the critical layer scales with y+ ~Rτ+ 2 / 3),'' both untenable assumptions, but ignored citation of papers Afzal 1982 onwards on pipe flow. The present turbulent boundary layer work shows that Reynolds shear maxima, shape factor and turbulent bursting time scale with mesolayer variables and Taylor length/time scale. Residence, Embassy Hotel Rasal Gang Aligarh 202001 UP India.

  7. Efecto del etnocentrismo sobre la tendencia a usar el nombre de marca en las decisiones de compra. Una aplicación al caso del calzado en España y Rusia

    Directory of Open Access Journals (Sweden)

    Liudmila Ostrovskaya

    2013-09-01

    Full Text Available El presente trabajo analiza el grado en que la Tendencia a usar el Nombre de Marca (TBN se ve afectada por el etnocentrismo del consumidor (CET y se pretende determinar si esta influencia varía en función de la edad o el sexo. Para ello se emplea una encuesta basada en la Web y realizada en dos países (España y Rusia, utilizando un muestreo adaptativo. Los datos, provenientes de 321 españoles y 375 rusos, fueron evaluados haciendo uso de la escala de Bristow, D.N., Schneider, K.C. & Schuler, D.K. (2002, para medir la TBN, y la escala de Shimp & Sharma (1987, para la CET, verificando sus invariancias. De este modo se advierte que el CET no tiene influencia sobre la TBN, aun haciendo una discriminación por grupos de edad o sexo. Los resultados obtenidos se refieren a dos países con diferentes valores culturales y distinto nivel de desarrollo económico, lo que ofrece una nueva perspectiva, que va más allá de estudios aislados sobre las marcas o países específicos. El trabajo muestra que existen, entre los dos países, algunos rasgos similares respecto al BN y al CET, sirviendo como input para desarrollar estrategias de diferenciación y segmentación.

  8. A case report of aphallia with urorectal septum malformation sequence in a newborn: a very rarely seen condition

    Directory of Open Access Journals (Sweden)

    Sharma D

    2015-12-01

    Full Text Available Deepak Sharma,1 Ravinder Singh,2 Sweta Shastri3 1Department of Neonatology, Fernandez Hospital, Hyderabad, 2Department of Pediatrics, Civil Hospital, Hisar, Haryana, 3Department of Pathology, NKP Salve Medical College, Nagpur, Maharashtra, India Abstract: Aphallia (absence of penis is an extremely rare abnormality which has rarely been described in medical literature and can be part of the urorectal septum malformation sequence (URSMS. URSMS has hardly been reported in medical literature and includes the absence of perineal and anal openings in association with ambiguous genitalia and urogenital, colonic, and lumbosacral anomalies. This case report tells the importance of detailed examination of infants that are diagnosed with aphallia. We report a case of a newborn who was diagnosed as aphallia with the URSMS syndrome after birth. The neonate had an endocardial cushion defect (atrial septal defect and ventricular septal defect and bilateral agenesis of the kidney. The neonate succumbed to death secondary to hypoplastic lung leading to respiratory failure. Keywords: aphallia, urorectal septum malformation sequence, cloacal membrane, hindgut development, congenital aphallia, anorectal malformation

  9. Effect of turbulence models on predicting convective heat transfer to hydrocarbon fuel at supercritical pressure

    Directory of Open Access Journals (Sweden)

    Tao Zhi

    2016-10-01

    Full Text Available A variety of turbulence models were used to perform numerical simulations of heat transfer for hydrocarbon fuel flowing upward and downward through uniformly heated vertical pipes at supercritical pressure. Inlet temperatures varied from 373 K to 663 K, with heat flux ranging from 300 kW/m2 to 550 kW/m2. Comparative analyses between predicted and experimental results were used to evaluate the ability of turbulence models to respond to variable thermophysical properties of hydrocarbon fuel at supercritical pressure. It was found that the prediction performance of turbulence models is mainly determined by the damping function, which enables them to respond differently to local flow conditions. Although prediction accuracy for experimental results varied from condition to condition, the shear stress transport (SST and launder and sharma models performed better than all other models used in the study. For very small buoyancy-influenced runs, the thermal-induced acceleration due to variations in density lead to the impairment of heat transfer occurring in the vicinity of pseudo-critical points, and heat transfer was enhanced at higher temperatures through the combined action of four thermophysical properties: density, viscosity, thermal conductivity and specific heat. For very large buoyancy-influenced runs, the thermal-induced acceleration effect was over predicted by the LS and AB models.

  10. Comparison of Shear Bond Strength and Estimation of Adhesive Remnant Index between Light-cure Composite and Dual-cure Composite: An in vitro Study.

    Science.gov (United States)

    Verma, Geeta; Trehan, Mridula; Sharma, Sunil

    2013-09-01

    To measure and compare the shear bond strength and adhesive remnant index of light-cure composite. (Enlight, Ormco.) and dual-cure composite (Phase II dual cure, Reliance Ortho). Sixty extracted human premolar teeth were divided into two groups: group I (blue): conventional light cure composite resin. (Enlight, Ormco.) and group II (green): dual cure composite resin. (Phase II dual cure, Reliance Ortho.) with 30 teeth in each group. These samples were tested on the universal testing machine to measure the shear bond strength. Student t-test showed that the mean shear bond strength of the conventional light cure group (8.54 MPa - 10.42 MPa) was significantly lower than dual cure group (10.45 MPa -12.17 MPa). These findings indicate that the shear bond strength of dual-cure composite resin (Phase II dual cure, Reliance Ortho) is comparatively higher than conventional light-cure composite resin (Enlight, Ormco). In the majority of the samples, adhesive remnant index (ARI) scores were 4 and 5 in both the groups whereas score 1 is attained by the least number of samples in both the groups. How to cite this article: Verma G, Trehan M, Sharma S. Comparison of Shear Bond Strength and Estimation of Adhesive Remnant Index between Light-cure Composite and Dual-cure Composite: An in vitro Study. Int J Clin Pediatr Dent 2013;6(3):166-170.

  11. Association between body mass index and risk of breast cancer among females of north India

    Science.gov (United States)

    Singh, Mahavir; Jangra, Babita

    2013-01-01

    Background: Worldwide, breast cancer is most common cancer among women. In India and other developing countries, breast carcinoma ranks second only to cervical carcinoma among women. Although studies have been done globally, to find association between BMI and breast cancer, very few studies in India document any such association. Purpose: To find out the association between BMI and breast cancer. Materials and Methods: A Case-control study was done from August 2009 - July 2010 in the wards of General Surgery and Oncosurgery at Pt.B.D.Sharma, PGIMS Rohtak, Haryana. A total of 128 histopathologically confirmed new cases of breast cancer during the study period were taken as cases. Equal number of controls was selected by simple random sampling. Controls were matched for age with range of ±2 years. Subjects were interviewed using a pretested questionnaire after obtaining written informed consent. Data were analyzed by applying appropriate statistical tests using SPSS version 17. Results: Age group of the cases was 25 - 78 years, while that of the controls was 24 - 79 years. Proportion of cases and controls living in rural areas were more than those living in urban areas. A significant association of breast cancer cases was found with high BMI and high fat intake Conclusion: Obesity and high fat intake are the significant risk factors, which are modifiable. So women should be encouraged to take care of all these factors. Maximum cases presented in late stages so public awareness of this fatal disease must be developed. PMID:24455581

  12. Subperiosteal hematoma from peribulbar block during cataract surgery leading to optic nerve compression in a patient with parahemophilia

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    Khokhar S

    2015-12-01

    Full Text Available Sudarshan Khokhar,1 Bhagabat Nayak,1 Bharat Patil,1 Milind Devidas Changole,1 Gautam Sinha,1 Reetika Sharma,1 Lipika Nayak2 1Dr RP Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India; 2Department of Pediatrics, Loknayak Hospital, Maulana Azad Medical College, Delhi, India Abstract: A 17-year-old male presented with gradual painless diminution of vision since childhood. Slit lamp examination revealed both eyes having congenital cataract. Right eye lens aspiration was performed but was uneventful, and he prepared for left eye surgery after 7 days. Immediately after giving a peribulbar block, a complete akinesia, tight eyelids, and stony hard eyeball was noted. An abaxial proptosis of 7 mm was noted. Lateral canthotomy and inferior cantholysis were done and proptosis reduced to 5 mm. Bleeding time–clotting time was normal. Proptosis worsened to 8 mm the next day. Contrast-enhanced computed tomography scan showed inferolateral subperiosteal hematoma, but drainage could not be performed due to prolonged prothrombin time and activated prothrombin time. Fresh frozen plasma was transfused. Tarsorrhaphy was performed for exposure keratopathy after his coagulation profile became normal. Hematology evaluation after 2 weeks detected factor V deficiency, and was diagnosed as Owren's disease or parahemophilia. Keywords: peribulbar block, hematoma, subperiosteal, parahemophilia, optic nerve compression

  13. New non-LTE model of OH(v) in the mesopshere/lower thermosphere

    Science.gov (United States)

    Panka, Peter; Kutepov, Alexander; Kalogerakis, Konstantinos; Janches, Diego; Feofilov, Artem; Rezac, Ladi; Marsh, Daniel; Yigit, Erdal

    2017-04-01

    We present a new detailed non-LTE model of OH(v) for the nighttime mesosphere/lower thermosphere. The model accounts for chemical production of vibrationally excited OH and for various vibrational-vibrational (VV) and vibrational-translational (VT) energy exchanges with main atmospheric constituents. The new feature was added to account for the "indirect" vibrational-electronic (VE) mechanism OH(v)→O(1D)→N2(v) of the OH vibrational energy transfer to N2, recently suggested by Sharma et al. [2015] and confirmed through laboratory studies by Kalogerakis et al. [2016]. We study the impact of this mechanism on the OH(v) populations and emissions in the two SABER channels at 1.6 and 2.0 μm. We also discuss the implications this mechanism will have on the retrieval of OH and O densities, as well as its effects on the nighttime CO2 density retrievals from the SABER 4.3 μm channel.

  14. Ferns and fern allies of District Shopian, Kashmir Valley, India

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    SHAKOOR A. MIR

    2015-04-01

    Full Text Available Abstract. Mir SA, Mishra AK, Pala SA, Reshi ZA, Sharma MP. Ferns and fern allies of District Shopian, Kashmir Valley, India Biodiversitas 16: 27-43. Shopian, recently created hilly district of Kashmir valley, Jammu and Kashmir is surrounded by the lofty mountains of Pir-Panjal range. More than half area of district is occupied by different forests, subalpine, alpine and mountainous zones. Great altitudinal variation, adequate rainfall, high forest cover, large number of streams, springs and topographic variations render the district worthy for supporting rich fern flora. Therefore, the current study was aimed to undertake in-depth systematic survey of different habitats of Shopian for the collection of diversity of pteridophytes. Specimens were collected during 2010, 2011 and 2012 growing seasons from June to November. A total 81 species of ferns and fern allies belonging 27 genera and 11 families were reported. The dominant families of the region are Dryopteridaceae (25 species followed by Woodsiaceae (16 species, Aspleniaceae (13 species and Pteridaceae (12 species. Similarly, the dominant genera collected from here are Dryopteris (14 species, Asplenium (13, Polystichum (11 species and Athyrium (6 species. A list of the fern and fern allies, along with update nomenclature, their selected Synonym, diagnostic features, distributional and ecological notes have been provided here.

  15. Characterization of perceived hyperoxia in isolated primary cardiac fibroblasts and in the reoxygenated heart.

    Science.gov (United States)

    Roy, Sashwati; Khanna, Savita; Wallace, William A; Lappalainen, Jani; Rink, Cameron; Cardounel, Arturo J; Zweier, Jay L; Sen, Chandan K

    2003-11-21

    Under normoxic conditions, pO2 ranges from 90 to Bierl, M., Pendyala, S., Levy, D., Sharma, N., Venojarvi, M., Strauch, A., Orosz, C. G., and Sen, C. K. (2003) Circ. Res. 92, 264-271). Here, we sought to characterize the genomic response to perceived hyperoxia in CF using GeneChips trade mark. Candidate genes were identified, confirmed and clustered. Cell cycle- and differentiation-associated genes represented a key target of perceived hyperoxia. Bioinformatics-assisted pathway reconstruction revealed the specific signaling processes that were sensitive to perceived hyperoxia. To test the significance of our in vitro findings, a survival model of rat heart focal ischemia-reperfusion (I-R) was investigated. A significant induction in p21 mRNA expression was observed in I-R tissue. The current results provide a comprehensive molecular definition of perceived hyperoxia in cultured CF. Furthermore, the first evidence demonstrating activation of perceived hyperoxia sensitive genes in the cardiac I-R tissue is presented.

  16. A STUDY TO FIND CORRELATION BETWEEN DERMATOGLYPHIC PATTERNS AND ABO BLOOD GROUPS

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    Usha Verma

    2015-09-01

    Full Text Available Background: Dermatoglyphics, the study of fingerprints are constant and individualistic. It has been found useful in forensic medicine and identification purpose. It is useful in medical diagnosis of genetically inherited diseases and in detection of crimes. Objectives: The present study was conducted to correlate between digital dermatoglyphics patterns in ABO, Rh blood groups and to evaluate their significance. Methods: A total of 200 first year MBBS students of Pt. B.D. Sharma PGIMS, Rohtak with known blood groups from age group 17-22 yrs were included in the study. Fingerprints were obtained by Ink method. Parameters studied were arches, whorls, loops. Results: Majority of the subjects (43.5% in the study were of blood group A followed by blood group O, A and AB of whom 94.5% were Rh-positive. The general distribution of pattern of finger print showed high frequency (51.87% of loops followed by whorls and arches. Almost same order was noticed in both Rh-positive and Rh-negative individuals or A, B, AB and O blood groups, except blood group O-ve which showed more whorls. Conclusion: There is an association between distribution of finger print pattern and blood groups.

  17. Epidemiology of chronic obstructive pulmonary disease: a descriptive study in the mid-western region of Nepal

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    Bhandari R

    2012-04-01

    Full Text Available Ramjee Bhandari1, Rajan Sharma21Health Research and Social Development Forum, 2Integrated Rural Health Development Training Center, Kathmandu, NepalBackground: The purpose of this study was to analyze the distribution of chronic obstructive pulmonary disease (COPD in terms of time, place, and person among inpatients at the Mid Western Regional Hospital (MWRH in Nepal.Methods: A descriptive cross-sectional study was carried out by analyzing trends using secondary data for the fiscal years 2006–2009 in the inpatient department of the MWRH.Results: The majority of patients admitted for treatment of COPD were women (60% and from higher ethnic groups (having a comparative advantage in terms of social and economic status, with a greater prevalence among those aged 60–69 years (37% of overall cases. The incidence of COPD increased in consecutive years, with the highest load during the winter months. The cases were most concentrated in places with easiest access to the hospital.Conclusion: COPD was found in higher proportions among women, those aged 60–69 years, and upper caste groups, during the cold months, and among residents of areas near the hospital in the mid-western region of Nepal. It is recommended that further detailed research and health education regarding COPD be carried out to reduce its burden and associated losses.Keywords: chronic obstructive pulmonary disease, Mid Western Regional Hospital, Surkhet, trend

  18. An updated conspectus of grasses of Punjab (India

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    Amarjit Singh Soodan

    2013-01-01

    Full Text Available Poaceae is the fourth largest family of the flowering plants. It includes about 700-800 genera and 11000-13000 species distributed worldwide. The family has unmatched ecological and economic importance. With its origin in the early cretaceous and major diversification in the mid Cenozoic, the family at present covers nearly a fifth of land surface and occurs in nearly all the habitats of the world. With a sub tropical ecology and an agrarian economy of Punjab, grasses comprise the most significant group in the region. Despite an overwhelming significance, taxonomic studies in grasses have not received sufficient attention in the region. It is only in the work of Sharma and Khosla (1989 that grass species have been classified into subfamilies and tribes. However, after the establishment of the Grass Phylogeny Working Group (GPWG the world has witnessed a renaissance in grass systematics. But, India remains an ‘undercollected’ country as far as grass diversity is concerned. Our work on the exploration and systematics of the grass flora of the region is an effort to consolidate and update the information on the diversity of grasses of the studied area. The present studies have brought the cumulative species number to 192 including seven new reports. The species representation of subfamilies is: Aristidoideae (5 Arundinoideae (5 Bambusoideae (4, Centothecoideae (1, Chloridoideae (55 Erhartoideae (3, Panicoideae (98 and Pooideae (21.

  19. Clinical neurorestorative progresses in cerebral palsy

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    Sharma A

    2017-02-01

    Full Text Available Alok Sharma,1 Tongchao Geng,2 Hemangi Sane,3 Pooja Kulkarni3 1Department of Medical Services & Clinical Research, NeuroGen Brain and Spine Institute, Mumbai, India; 2Department of Neurology, Yuquan Hospital, Tsinghua University, Beijing, People’s Republic of China; 3Department of Research and Development, Neurogen Brain and Spine Institute, Mumbai, India Abstract: Cerebral palsy (CP, group of permanent nonprogressive clinical disorders in children, is caused by damage to the immature brain. Conventionally available treatments for CP are mainly targeted toward management of its symptoms. With the upcoming field of neurorestorative strategies, we are now able to repair the core brain damage in CP. There are various drugs, stem cells, etc, which have been implicated to have neurorestorative properties. Autologous bone marrow stem cells, umbilical cord stem cells, neural stem cells, and olfactory ensheathing cells have shown the safety and efficacy in preliminary studies. Here, we review the different medicines and cell types that have shown beneficial effects in clinical studies. We propose that combination strategies may be the future of neurorestoration. Keywords: stem cell therapy, bone marrow, umbilical cord, neural cells, regenerative medicine, brain

  20. A Multi-Objective Optimization Technique to Model the Pareto Front of Organic Dielectric Polymers

    Science.gov (United States)

    Gubernatis, J. E.; Mannodi-Kanakkithodi, A.; Ramprasad, R.; Pilania, G.; Lookman, T.

    Multi-objective optimization is an area of decision making that is concerned with mathematical optimization problems involving more than one objective simultaneously. Here we describe two new Monte Carlo methods for this type of optimization in the context of their application to the problem of designing polymers with more desirable dielectric and optical properties. We present results of applying these Monte Carlo methods to a two-objective problem (maximizing the total static band dielectric constant and energy gap) and a three objective problem (maximizing the ionic and electronic contributions to the static band dielectric constant and energy gap) of a 6-block organic polymer. Our objective functions were constructed from high throughput DFT calculations of 4-block polymers, following the method of Sharma et al., Nature Communications 5, 4845 (2014) and Mannodi-Kanakkithodi et al., Scientific Reports, submitted. Our high throughput and Monte Carlo methods of analysis extend to general N-block organic polymers. This work was supported in part by the LDRD DR program of the Los Alamos National Laboratory and in part by a Multidisciplinary University Research Initiative (MURI) Grant from the Office of Naval Research.

  1. Observational study to calculate addictive risk to opioids: a validation study of a predictive algorithm to evaluate opioid use disorder

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    Brenton A

    2017-05-01

    Full Text Available Ashley Brenton,1 Steven Richeimer,2,3 Maneesh Sharma,4 Chee Lee,1 Svetlana Kantorovich,1 John Blanchard,1 Brian Meshkin1 1Proove Biosciences, Irvine, CA, 2Keck school of Medicine, University of Southern California, Los Angeles, CA, 3Departments of Anesthesiology and Psychiatry, University of Southern California, Los Angeles, CA, 4Interventional Pain Institute, Baltimore, MD, USA Background: Opioid abuse in chronic pain patients is a major public health issue, with rapidly increasing addiction rates and deaths from unintentional overdose more than quadrupling since 1999. Purpose: This study seeks to determine the predictability of aberrant behavior to opioids using a comprehensive scoring algorithm incorporating phenotypic risk factors and neuroscience-associated single-nucleotide polymorphisms (SNPs. Patients and methods: The Proove Opioid Risk (POR algorithm determines the predictability of aberrant behavior to opioids using a comprehensive scoring algorithm incorporating phenotypic risk factors and neuroscience-associated SNPs. In a validation study with 258 subjects with diagnosed opioid use disorder (OUD and 650 controls who reported using opioids, the POR successfully categorized patients at high and moderate risks of opioid misuse or abuse with 95.7% sensitivity. Regardless of changes in the prevalence of opioid misuse or abuse, the sensitivity of POR remained >95%. Conclusion: The POR correctly stratifies patients into low-, moderate-, and high-risk categories to appropriately identify patients at need for additional guidance, monitoring, or treatment changes. Keywords: opioid use disorder, addiction, personalized medicine, pharmacogenetics, genetic testing, predictive algorithm

  2. Cushing's syndrome: epidemiology and developments in disease management

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    Sharma ST

    2015-04-01

    Full Text Available Susmeeta T Sharma,1 Lynnette K Nieman,1 Richard A Feelders2 1Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA; 2Division of Endocrinology, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands Abstract: Cushing’s syndrome is a rare disorder resulting from prolonged exposure to excess glucocorticoids. Early diagnosis and treatment of Cushing’s syndrome is associated with a decrease in morbidity and mortality. Clinical presentation can be highly variable, and establishing the diagnosis can often be difficult. Surgery (resection of the pituitary or ectopic source of adrenocorticotropic hormone, or unilateral or bilateral adrenalectomy remains the optimal treatment in all forms of Cushing’s syndrome, but may not always lead to remission. Medical therapy (steroidogenesis inhibitors, agents that decrease adrenocorticotropic hormone levels or glucocorticoid receptor antagonists and pituitary radiotherapy may be needed as an adjunct. A multidisciplinary approach, long-term follow-up, and treatment modalities customized to each individual are essential for optimal control of hypercortisolemia and management of comorbidities. Keywords: Cushing’s syndrome, hypercortisolemia, treatment, epidemiology

  3. Image registration and averaging of low laser power two-photon fluorescence images of mouse retina.

    Science.gov (United States)

    Alexander, Nathan S; Palczewska, Grazyna; Stremplewski, Patrycjusz; Wojtkowski, Maciej; Kern, Timothy S; Palczewski, Krzysztof

    2016-07-01

    Two-photon fluorescence microscopy (TPM) is now being used routinely to image live cells for extended periods deep within tissues, including the retina and other structures within the eye . However, very low laser power is a requirement to obtain TPM images of the retina safely. Unfortunately, a reduction in laser power also reduces the signal-to-noise ratio of collected images, making it difficult to visualize structural details. Here, image registration and averaging methods applied to TPM images of the eye in living animals (without the need for auxiliary hardware) demonstrate the structural information obtained with laser power down to 1 mW. Image registration provided between 1.4% and 13.0% improvement in image quality compared to averaging images without registrations when using a high-fluorescence template, and between 0.2% and 12.0% when employing the average of collected images as the template. Also, a diminishing return on image quality when more images were used to obtain the averaged image is shown. This work provides a foundation for obtaining informative TPM images with laser powers of 1 mW, compared to previous levels for imaging mice ranging between 6.3 mW [Palczewska G., Nat Med.20, 785 (2014) Sharma R., Biomed. Opt. Express4, 1285 (2013)].

  4. Novel and emerging approaches to combat adolescent obesity

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    Manoj Sharma

    2010-02-01

    Full Text Available Manoj Sharma, Paul BranscumHealth Promotion and Education and Public Health Sciences, University of Cincinnati, Cincinnati, OH, USAAbstract: Overweight and obesity continue to be health concerns facing today’s adolescent population. Along with metabolic and physical problems associated with obesity, today’s obese adolescents also face many psychological issues such as high rates of depression, anxiety, and social discrimination. Obesity is commonly recognized as having many causes, such as genetic, lifestyle and environmental. There are four major modalities for management of overweight and obesity in adolescents: dietary management, increasing physical activity, pharmacological therapy, and bariatric surgery. The purpose of this study was to conduct a review of novel and emerging approaches for preventing and managing adolescent obesity. It was found that while not always the case, theory driven approaches are being better utilized in newer interventions especially by those directed toward prevention. New theories that are being used are the theories of reasoned action, planned behavior, intervention mapping, and social marketing. Schools are found to be the most common place for such interventions, which is appropriate since virtually all children attend some form of private or public school. Limitations found in many studies include the underuse of process evaluations, the low number of studies attempted, environmental or policy changes, and that not all studies used a similar control group for comparison.Keywords: adolescent overweight, adolescent obesity, interventions

  5. Challenges to developing effective streptococcal vaccines to prevent rheumatic fever and rheumatic heart disease

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    Sharma A

    2014-05-01

    Full Text Available Abhinay Sharma, D Patric Nitsche-SchmitzDepartment of Medical Microbiology, Helmholtz Center for Infection Research, Braunschweig, GermanyAbstract: Acute rheumatic fever is a sequela of Streptococcus pyogenes and potentially of Streptococcus dysgalactiae subsp. equisimilis infections. Acute rheumatic fever is caused by destructive autoimmunity and inflammation in the extracellular matrix and can lead to rheumatic heart disease, which is the most frequent cardiologic disease that is acquired in youth. Although effective treatments are available, acute rheumatic fever and rheumatic heart disease remain serious threats to human health, which affect millions and cause high economic losses. This has motivated the search for a vaccine that prevents the causative streptococcal infections. A variety of potential vaccine candidates have been identified and investigated in the past. Today, new approaches are applied to find alternative candidates. Nevertheless, several obstacles lie in the way of an approved S. pyogenes vaccine for use in humans. Herein, a subjective selection of promising vaccine candidates with respect to the prevention of acute rheumatic fever/rheumatic heart disease and safety regarding immunological side effects is discussed.Keywords: autoimmune disease, side effects, M protein vaccine, molecular mimicry, coiled-coil, collagen binding, PARF

  6. Theory of dynamic force spectroscopy for kinetochore-microtubule attachments: rupture force distribution

    CERN Document Server

    Ghanti, Dipanwita

    2016-01-01

    Application of pulling force, under force-clamp conditions, to kinetochore-microtubule attachments {\\it in-vitro} revealed a catch-bond-like behavior. In an earlier paper ({\\it Sharma et al. Phys. Biol. (2014)} the physical origin of this apparently counter-intuitive phenomenon was traced to the nature of the force-dependence of the (de-)polymerization kinetics of the microtubules. In this brief communication that work is extended to situations where the external forced is ramped up till the attachment gets ruptured. In spite of the fundamental differences in the underlying mechanisms, the trend of variation of the rupture force distribution observed in our model kinetochore-microtubule attachment with the increasing loading rate is qualitatively similar to that displayed by the catch bonds formed in some other ligand-receptor systems. Our theoretical predictions can be tested experimentally by a straightforward modification of the protocol for controlling the force in the optical trap set up that was used in...

  7. Extraglottic airway devices: technology update

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    Sharma B

    2017-08-01

    Full Text Available Bimla Sharma, Chand Sahai, Jayashree Sood Department of Anaesthesiology, Pain and Perioperative Medicine, Sir Ganga Ram Hospital, New Delhi, India Abstract: Extraglottic airway devices (EADs have revolutionized the field of airway management. The invention of the laryngeal mask airway was a game changer, and since then, there have been several innovations to improve the EADs in design, functionality, safety and construction material. These have ranged from changes in the shape of the mask, number of cuffs and material used, like rubber, polyvinylchloride and latex. Phthalates, which were added to the construction material in order to increase device flexibility, were later omitted when this chemical was found to have serious adverse reproductive outcomes. The various designs brought out by numerous companies manufacturing EADs resulted in the addition of several devices to the airway market. These airway devices were put to use, many of them with inadequate or no evidence base regarding their efficacy and safety. To reduce the possibility of compromising the safety of the patient, the Difficult Airway Society (DAS formed the Airway Device Evaluation Project Team (ADEPT to strengthen the evidence base for airway equipment and vet the new extraglottic devices. A preuse careful analysis of the design and structure may help in better understanding of the functionality of a particular device. In the meantime, the search for the ideal EAD continues. Keywords: extraglottic airway devices, laryngeal mask airway, other extraglottic airway devices, safety, technology update

  8. Association between body mass index and risk of breast cancer among females of north India

    Directory of Open Access Journals (Sweden)

    Mahavir Singh

    2013-01-01

    Full Text Available Background: Worldwide, breast cancer is most common cancer among women. In India and other developing countries, breast carcinoma ranks second only to cervical carcinoma among women. Although studies have been done globally, to find association between BMI and breast cancer, very few studies in India document any such association. Purpose: To find out the association between BMI and breast cancer. Materials and Methods: A Case-control study was done from August 2009 - July 2010 in the wards of General Surgery and Oncosurgery at Pt.B.D.Sharma, PGIMS Rohtak, Haryana. A total of 128 histopathologically confirmed new cases of breast cancer during the study period were taken as cases. Equal number of controls was selected by simple random sampling. Controls were matched for age with range of ±2 years. Subjects were interviewed using a pretested questionnaire after obtaining written informed consent. Data were analyzed by applying appropriate statistical tests using SPSS version 17. Results: Age group of the cases was 25 - 78 years, while that of the controls was 24 - 79 years. Proportion of cases and controls living in rural areas were more than those living in urban areas. A significant association of breast cancer cases was found with high BMI and high fat intake Conclusion: Obesity and high fat intake are the significant risk factors, which are modifiable. So women should be encouraged to take care of all these factors. Maximum cases presented in late stages so public awareness of this fatal disease must be developed.

  9. Thoracic combined spinal epidural anesthesia for laparoscopic cholecystectomy in a geriatric patient with ischemic heart disease and renal insufficiency

    Directory of Open Access Journals (Sweden)

    Mehta N

    2015-12-01

    Full Text Available Nandita Mehta, Sunana Gupta, Atul Sharma, Mohd Reidwan Dar Department of Anesthesiology and Intensive Care, Acharya Shri Chander College of Medical Sciences and Hospital, Jammu, Jammu and Kashmir, India Abstract: Older people undergoing any surgery have a higher incidence of morbidity and mortality, resulting from a decline in physiological reserves, associated comorbidities, polypharmacy, cognitive dysfunction, and frailty. Most of the clinical trials comparing regional versus general anesthesia in elderly have failed to establish superiority of any single technique. However, the ideal approach in elderly is to be least invasive, thus minimizing alterations in homeostasis. The goal of anesthetic management in laparoscopic procedures includes management of pneumoperitoneum, achieving an adequate level of sensory blockade without any respiratory compromise, management of shoulder tip pain, provision of adequate postoperative pain relief, and early ambulation. Regional anesthesia fulfills all the aforementioned criteria and aids in quick recovery and thus has been suggested to be a suitable alternative to general anesthesia for laparoscopic surgeries, particularly in patients who are at high risk while under general anesthesia or for patients unwilling to undergo general anesthesia. In conclusion, we report results of successful management with thoracic combined spinal epidural for laparoscopic cholecystectomy of a geriatric patient with ischemic heart disease with chronic obstructive pulmonary disease and renal insufficiency. Keywords: geriatric anesthesia, bupivacaine, segmental anesthesia, laparoscopic surgery

  10. Collodion Baby with TGM1 gene mutation

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    Sharma D

    2015-09-01

    Full Text Available Deepak Sharma,1 Basudev Gupta,2 Sweta Shastri,3 Aakash Pandita,1 Smita Pawar4 1Department of Neonatology, Fernandez Hospital, Hyderguda, Hyderabad, Andhra Pradesh, 2Department of Pediatrics, Civil Hospital, Palwal, Haryana, 3Department of Pathology, NKP Salve Medical College, Nagpur, Maharashtra, 4Department of Obstetrics and Gynaecology, Fernandez Hospital, Hyderguda, Hyderabad, Andhra Pradesh, IndiaAbstract: Collodion baby (CB is normally diagnosed at the time of birth and refers to a newborn infant that is delivered with a lambskin-like membrane encompassing the total body surface. CB is not a specific disease entity, but is a common phenotype in conditions like harlequin ichthyosis, lamellar ichthyosis, nonbullous congenital ichthyosiform erythroderma, and trichothiodystrophy. We report a CB that was brought to our department and later diagnosed to have TGM1 gene c.984+1G>A mutation. However, it could not be ascertained whether the infant had lamellar ichthyosis or congenital ichthyosiform erythroderma (both having the same mutation. The infant was lost to follow-up.Keywords: cellophane membrane, c.984+1G>A mutation, lamellar ichthyosis, nonbullous congenital ichthyosiform erythroderma, parchment membrane, TGM1 gene

  11. International Competitiveness Based on Resources – Study of the Relation amog Resources and The International Dtrategies in the Biggest Exporting Companies of the Brazilian Footwear Sector

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    Sérgio Henrique Arruda Cavalcante Forte

    2007-01-01

    Full Text Available The internationalization of companies refers to a strategy to get greater presence in the international market. As the companies need to make use of strategical resources for their insertion in the international market, was searched to answer: Is there a relation between the evolution of the strategical resources and the strategies of internationalization in great exporting companies of the Brazilian footwear sector? For the theoretical base were used the classifications of the resources of Fahy (2002 and the strategies of internationalization of Sharma and Erramilli (2004. The study searched to rescue the dynamic character of the Resouce-based View. The method of the research was the quantitative and explicative nature. The data were collected from 2004 to 2005, with 15 great exporting companies of the Brazilian footwear sector and had been analyzed by the Cluster Analysis in the entrance in the international market, in the current situation and in 2010. It was concluded that the companies which use more complex strategies of internationalization, at the entrance moment and in the future, consider more strategical the capabilities, then the tangible resources and finally the intangible resources. However, in the current situation, they consider more strategical the capabilities, then the intangible resources and finally, the tangible resources.

  12. L x-ray production cross sections in Th and U at 17.8, 25.8 and 46.9 keV photon energies

    Energy Technology Data Exchange (ETDEWEB)

    Kumar, Ajay; Shahi, J.S.; Mehta, D.; Singh, Nirmal [Department of Physics, Panjab University, Chandigarh (India); Puri, Sanjiv [Department of Physics, SLIET, Longowal (India); Garg, M.L. [Department of Biophysics, Panjab University, Chandigarh (India)

    2001-02-28

    The L x-ray production (XRP) differential cross sections in Th and U have been measured at the 17.8 keV incident photon energy (E{sub L3}Sharma and Allawadhi 1999 J. Phys. B: At. Mol. Opt. Phys. 32 2343), the present measurements rule out the possibility of a strong angular dependence of differential cross sections for various L{sub 3} subshell x-rays following selective photoionization of the L{sub 3} subshell. Integral L XRP cross sections at the 17.8, 25.8 and 46.9 keV photon energies, deduced assuming isotropic emission of the L x-rays, are found to be in good agreement with those evaluated using the most reliable theoretical values of L{sub i} (i=1,2,3) subshell photoionization cross sections, fluorescence yields, x-ray emission rates and Coster-Kronig transition probabilities. (author)

  13. A study of synthetic large scales in turbulent boundary layers

    Science.gov (United States)

    Duvvuri, Subrahmanyam; Luhar, Mitul; Barnard, Casey; Sheplak, Mark; McKeon, Beverley

    2013-11-01

    Synthetic spanwise-constant spatio-temporal disturbances are excited in a turbulent boundary layer through a spatially impulsive patch of dynamic wall-roughness. The downstream flow response is studied through hot wire anemometry, pressure measurements at the wall and direct measurements of wall-shear-stress made using a novel micro-machined capacitive floating element sensor. These measurements are phase-locked to the input perturbation to recover the synthetic large-scale motion and characterize its structure and wall signature. The phase relationship between the synthetic large scale and small scale activity provides further insights into the apparent amplitude modulation effect between them, and the dynamics of wall-bounded turbulent flows in general. Results from these experiments will be discussed in the context of the critical-layer behavior revealed by the resolvent analysis of McKeon & Sharma (J Fluid Mech, 2010), and compared with similar earlier work by Jacobi & McKeon (J Fluid Mech, 2011). Model predictions are shown to be in broad agreement with experiments. The support of AFOSR grant #FA 9550-12-1-0469, Resnick Institute Graduate Research Fellowship (S.D.) and Sandia Graduate Fellowship (C.B.) are gratefully acknowledged.

  14. A Comparative Evaluation of Effect of Different Chemical Solvents on the Shear Bond Strength of Glass Fiber reinforced Post to Core Material.

    Science.gov (United States)

    Sharma, Ashish; Samadi, Firoza; Jaiswal, Jn; Saha, Sonali

    2014-01-01

    To compare the effect of different chemical solvents on glass fiber reinforced posts and to study the effect of these solvents on the shear bond strength of glass fiber reinforced post to core material. This study was conducted to evaluate the effect of three chemical solvents, i.e. silane coupling agent, 6% H2O2 and 37% phosphoric acid on the shear bond strength of glass fiber post to a composite resin restorative material. The changes in post surface characteristics after different treatments were also observed, using scanning electron microscopy (SEM) and shear bond strength was analyzed using universal testing machine (UTM). Surface treatment with hydrogen peroxide had greatest impact on the post surface followed by 37% phosphoric acid and silane. On evaluation of the shear bond strength, 6% H2O2 exhibited the maximum shear bond strength followed in descending order by 37% phosphoric acid and silane respectively. The surface treatment of glass fiber post enhances the adhesion between the post and composite resin which is used as core material. Failure of a fiber post and composite resin core often occurs at the junction between the two materials. This failure process requires better characterization. How to cite this article: Sharma A, Samadi F, Jaiswal JN, Saha S. A Comparative Evaluation of Effect of Different Chemical Solvents on the Shear Bond Strength of Glass Fiber Reinforced Post to Core Material. Int J Clin Pediatr Dent 2014;7(3):192-196.

  15. Correction of a Severely Rotated Maxillary Incisor by Elastics in Mixed Dentition Complicated by a Mesiodens.

    Science.gov (United States)

    Sidiq, Mohsin; Yousuf, Asif; Bhat, Manohar; Sharma, Rajesh; Bhargava, Neha; Ganta, Shravani

    2015-01-01

    The aim of this case study was to report a potentially convenient approach instead of a conventional orthodontic procedure for correcting severe rotation of anterior tooth of an 11-year-old Indian boy, with a mixed dentition class I malocclusion. The child reported seeking treatment for severely rotated upper right central incisor with mesiodens and a single tooth crossbite. The supernumerary tooth was first extracted and bondable buttons were placed on the rotated tooth, an appliance composed of a removable plate with Adam's clasp with distal extension and a loop for engagement of elastics was delivered. Circumferential supracrestal fibrotomy was performed on the corrected derotated tooth. Then, Hawley's appliance with a z-spring and posterior bite plane was fabricated and placed for correction of crossbite. Thus, this removable appliance can be a simplified and a cost-effective treatment alternative for derotation of anterior tooth, especially during the mixed dentition period. How to cite this article: Sidiq M, Yousuf A, Bhat M, Sharma R, Bhargava N, Ganta S. Correction of a Severely Rotated Maxillary Incisor by Elastics in Mixed Dentition Complicated by a Mesiodens. Int J Clin Pediatr Dent 2015;8(3):234-238.

  16. Applicability of Bolton's Analysis: A Study on Jaipur Population.

    Science.gov (United States)

    Trehan, Mridula; Agarwal, Sonahita; Sharma, Sunil

    2012-05-01

    This study was undertaken to compare the Bolton's anterior and overall ratios among males and females in Jaipur population. One hundred study models (50 males and 50 females) of orthodontic patients were randomly selected from the Department of Orthodontics, Mahatma Gandhi Dental College, Jaipur. The normative data for the mesiodistal widths of males and females were established and the anterior and overall ratios were obtained for both males and females. It was observed that were no significant differences in both the ratios in males and females. Hence, both the ratios were obtained for the sample as a whole. These ratios were found to be similar to the Boltons standard with no significant differences. Therefore, it can be concluded that Boltons standards can be applied to this population irrespective of sex or ethnic background. How to cite this article: Trehan M, Agarwal S, Sharma S. Applicability of Bolton's Analysis: A Study on Jaipur Population. Int J Clin Pediatr Dent 2012;5(2):113-117.

  17. Case of early-disseminated Rhizopus microsporus var. microsporus mucormycosis in a renal transplant patient

    Directory of Open Access Journals (Sweden)

    Sharma D

    2016-06-01

    Full Text Available Dikshya Sharma,1 Kumud Dahal,2 Bandana Pathak,3 Udip Dahal4 1Staten Island University Hospital, Staten Island, NY, 2University of Illinois College of Medicine, 3OSF Saint Francis Medical Center, Peoria, IL, 4University of Utah, Salt Lake City, UT, USA Abstract: Mucormycosis is a rare infection caused by the ubiquitous filamentous fungi of the order Mucorales and class Zygomycetes. These species are vasotropic, causing rapid onset of tissue infarctions and necrosis and subsequent thrombosis by invading vascular bed. The disease spectrum ranges from involvement of skin, sinuses, lung, and brain to disseminated and mostly fatal infections, especially in immunocompromised hosts. Here, we present a case of a fatal disseminated mucormycosis in a 56-year-old female who had deceased donor renal allograft transplantation ~2 weeks prior to presentation. She presented with shortness of breath and dry cough. Despite being on broad-spectrum antibiotics/antifungals and proper management by transplant, infectious disease, and primary team, she died within 3 weeks of admission. Autopsy showed disseminated mucormycosis of lungs and thyroid. Disseminated infection within 2 weeks of solid organ transplantation in this patient was one of the rare features of mucormycosis. Keywords: Zygomycetes, immunocompromised, transplant

  18. Characterization of oil and gas reservoir heterogeneity; Final report, November 1, 1989--June 30, 1993

    Energy Technology Data Exchange (ETDEWEB)

    Sharma, G.D.

    1993-09-01

    The Alaskan North Slope comprises one of the Nation`s and the world`s most prolific oil province. Original oil in place (OOIP) is estimated at nearly 70 BBL (Kamath and Sharma, 1986). Generalized reservoir descriptions have been completed by the University of Alaska`s Petroleum Development Laboratory over North Slope`s major fields. These fields include West Sak (20 BBL OOIP), Ugnu (15 BBL OOIP), Prudhoe Bay (23 BBL OOIP), Kuparuk (5.5 BBL OOIP), Milne Point (3 BBL OOIP), and Endicott (1 BBL OOIP). Reservoir description has included the acquisition of open hole log data from the Alaska Oil and Gas Conservation Commission (AOGCC), computerized well log analysis using state-of-the-art computers, and integration of geologic and logging data. The studies pertaining to fluid characterization described in this report include: experimental study of asphaltene precipitation for enriched gases, CO{sup 2} and West Sak crude system, modeling of asphaltene equilibria including homogeneous as well as polydispersed thermodynamic models, effect of asphaltene deposition on rock-fluid properties, fluid properties of some Alaskan north slope reservoirs. Finally, the last chapter summarizes the reservoir heterogeneity classification system for TORIS and TORIS database.

  19. SP (N) Treatment of Frustrated Spin Dimer Systems in Magnetic Field

    Science.gov (United States)

    Maltseva, Marianna; Flint, Rebecca; Coleman, Piers

    2007-03-01

    We present a Schwinger boson treatment of a frustrated bilayer dimer spin system using a reformulation of the SP (N) approach to frustrated spin systems. Unlike previous SP (N) approaches[1], our starting model is composed uniquely of SP (N) spin generators, which permits a more symmetric treatment of antiferromagnetic and ferromagnetic bonds. We apply our methods to model the spin condensation process that occurs in Ba CuSi2O6. One of the issues of particular interest is the dependence of the interlayer order-from-disorder effects[4] on the applied magnetic field, and the interesting possibility that these couplings vanish at the critical field[2,3]. [1] S. Sachdev, N. Read, International Journal of Modern Physics B 5, 219 (1991). [2] S. E. Sebastian, N. Harrison, C. D. Batista, L. Balicas, M. Jaime, P. A. Sharma, N. Kawashima, I. R. Fisher, Nature 441, pp 617-620 (2006). [3] C. D. Batista, J. Schmalian, N. Kawashima, S. E. Sebastian, N. Harrison, M. Jaime, I. R. Fisher, cond-mat/0608703. [4] M. Maltseva, P. Coleman, Phys. Rev. B 72, 174415-9 (2005).

  20. ATP potentiates competitive inhibition of guanylyl cyclase A and B by the staurosporine analog, Gö6976: reciprocal regulation of ATP and GTP binding.

    Science.gov (United States)

    Robinson, Jerid W; Potter, Lincoln R

    2011-09-30

    Natriuretic peptides and ATP activate and Gö6976 inhibits guanylyl cyclase (GC)-A and GC-B. Here, the mechanism of inhibition was determined. Gö6976 progressively increased the Michaelis-Menten constant and decreased the Hill coefficient without reducing the maximal velocity of GC-A and GC-B. In the presence of 1 mm ATP, the K(i) was 1 μm for both enzymes. Inhibition of GC-B was minimal in the absence of ATP, and 1 mm ATP increased the inhibition 4-fold. In a reciprocal manner, 10 μm Gö6976 increased the potency of ATP for GC-B 4-fold. In contrast to a recent study (Duda, T., Yadav, P., and Sharma, R. K. (2010) FEBS J. 277, 2550-2553), neither staurosporine nor Gö6976 activated GC-A or GC-B. This is the first study to show that Gö6976 reduces GTP binding and the first demonstration of a competitive inhibitor of a receptor guanylyl cyclase. We conclude that Gö6976 reduces GTP binding to the catalytic site of GC-A and GC-B and that ATP increases the magnitude of the inhibition.

  1. New records of Pteridophytes for Kashmir Valley, India

    Directory of Open Access Journals (Sweden)

    SHAKOOR A. MIR

    2014-10-01

    Full Text Available Mir SA, Mishra AK, Reshi ZA, Sharma MP. 2014. New Records of Pteridophytes for Kashmir Valley, India. Biodiversitas 15: 131-136. During the recent field survey of district Shopian four species of Pteridophytes are reported for the first time that constitutes new records for Kashmir valley. These species are Hypolepis polypodioides (Blume Hook, Pteris stenophylla Wall. ex Hook. & Grev., Dryopteris subimpressa Loyal and Dryopteris wallichiana (Spreng. Hylander. The diagnostic features of H. polypodioides are presence of long-creeping slender rhizome and eglandular, colorless or brown tinged hairs throughout the frond. P. stenophylla is characterized by having dimorphic fronds and 3 to 5 pinnae clustered at stipe apex. D. subimpressa is marked by pale-green lamina and the largest basiscopic basal pinnule in the lowest pair of pinnae. Similarly, the characteristic features of D. wallichiana are presence of huge frond size, glossier and dark-green lamina and dense browner scales in stipe and rachis. In present communication taxonomic description, synonyms, ecology and photographs are provided for each of these newly recorded species.

  2. PATTERN OF TRAUMA AT A GOVERNMENT TERTIARY CARE TEACHING HOSPITAL OF HARYANA

    Directory of Open Access Journals (Sweden)

    Surender

    2014-06-01

    Full Text Available OBJECTIVE: To study the pattern of trauma related surgical emergencies in a government tertiary care public hospital in Haryana. DESIGN: Prospective analysis of patients reported during period of June 2010. SETTING: Accident and Emergency Department, Pt. B.D. Sharma PGIMS, Rohtak. RESULT: A total of 1501 patients reported during the study period and out of which most common mode of trauma were road side accidents (62.23%. Among all patients mostly (57.76% were non referred. Male patients (78.22% outnumbered female patients (21.78%. Most common injury was soft tissue injury of limbs (22.88% and most of the patients (85.25% were managed conservatively. Orthopedic operations were most commonly performed procedure in all operated patients. Mortality of trauma in accident and emergency department during the study period was 1.99%. CONCLUSION: The study revealed that commonest affected populations in trauma were of productive age group. Therefore it is the need of hour to persuade health system administrators to set up some education program to increase the awareness of families and teenagers regarding trauma

  3. 3D critical layers in fully-developed turbulent flows

    Science.gov (United States)

    Saxton-Fox, Theresa; McKeon, Beverley

    2016-11-01

    Recent work has shown that 3D critical layers drive self-sustaining behavior of exact coherent solutions of the Navier-Stokes equations (Wang et al. 2007; Hall and Sherwin 2010; Park and Graham 2015). This study investigates the role of 3D critical layers in fully-developed turbulent flows. 3D critical layer effects are identified in instantaneous snapshots of turbulent boundary layers in both experimental and DNS data (Wu et al. 2014). Additionally, a 3D critical layer effect is demonstrated to appear using only a few resolvent response modes from the resolvent analysis of McKeon and Sharma 2010, with phase relationships appropriately chosen. Connections are sought to the thin shear layers observed in turbulent boundary layers (Klewicki and Hirschi 2004; Eisma et al. 2015) and to amplitude modulation observations (Mathis et al. 2009; Duvvuri and McKeon 2014). This research is made possible by the Department of Defense through the National Defense & Engineering Graduate Fellowship (NDSEG) Program and by the Air Force Office of Scientific Research Grant # FA9550-12-1-0060. The support of the Center for Turbulence Research (CTR) summer program at Stanford is gratefully acknowledged.

  4. Optimization Of Blasting Design Parameters On Open Pit Bench A Case Study Of Nchanga Open Pits

    Directory of Open Access Journals (Sweden)

    Victor Mwango Bowa

    2015-08-01

    Full Text Available Abstract In hard rock mining blasting is the most productive excavation technique applied to fragment insitu rock to the required size for efficient loading and crushing. In order to blast the insitu rock to the desired fragment size blast design parameter such as bench height hole diameter spacing burden hole length bottom charge specific charge and rock factor are considered. The research was carried out as a practical method on Nchanga Open Pits NOP ore Bench to optimize the blasting design parameters that can yield the required fragmentation size thereby reducing the shovel loading times and maximizing efficiency of the subsequent mining unit operations such as hauling and crushing. Fragmentation characteristics such as the mean fragment size were measured by means of a digital measuring tape and predicated using the Kuznetsov equation and rock factor value of ore bench was calculated using Lilly 1986 equations by means of rock characteristics. Traditional blasting design parameters were acquired for NOP and modified using Langerfors and Sharma P.A approaches. Several blast operations were conducted using both traditional and modified blasting design parameters on the same ore bench with the same geological conditions. Loading times of the shovel and fragment sizes were obtained after the blasts from ore bench where both the traditional and modified blasting design parameters were applied. Results show that mean fragment size and loading times were reduced from 51cm and 12minutes to 22cm and 3minutes where traditional and modified blasting design parameters were applied respectively.

  5. AISI 1030 ÇELİĞİNİN AŞINDIRICILI SU JETİ İLE KESİLMESİNDE YÜZEY PÜRÜZLÜLÜĞÜNÜN VE KESME ÖNÜ GEOMETRİSİNİN İNCELENMESİ

    Directory of Open Access Journals (Sweden)

    Adnan AKKURT

    2009-01-01

    Full Text Available Alternatif bir üretim yöntemi olarak gündeme gelen aşındırıcı su jeti (ASJ ile kesme, endüstriyel amaçlı malzemelerdeki gelişmelere paralellik gösterecek şekilde, işlenmesi güç malzemelerin biçimlendirilmesinde etkili bir yöntem olarak kullanılmaktadır. Bu çalışmada, endüstride yaygın kullanılan AISI 1030 malzemeden hazırlanan farklı kalınlıklardaki numuneler işleme parametrelerinden yanal hız değişken, diğer parametreler sabit tutularak, ASJ ile kesilmiş ve elde edilen yüzeylerin kesme önü geometrisi karakterize edilmiştir. Elde edilen sonuçlar dik kenar, keskin köşe ve benzeri yüzeylerin işlenmesinde aşındırıcılı su jeti ile kesme metodunun kullanılabileceğini göstermiştir.

  6. A New GIS based Application of Sequential Technique to Prospect Karstic Groundwater using Remotely Sensed and Geoelectrical Methods in Karstified Tepal Area, Shahrood, Iran

    Directory of Open Access Journals (Sweden)

    Fereydoun Sharifi

    2015-06-01

    Full Text Available In this research, recognition of karstic water-bearing zones using the management of exploration data in Kal-Qorno valley, situated in the Tepal area of Shahrood, has been considered. For this purpose, the sequential exploration method was conducted using geological evidences and applying remote sensing and geoelectrical resistivity methods in two major phases including the regional and local scales. Thus, geological structures and lithological units in regional scale have been investigated for groundwater potential. In this regard, suitable potential maps have been provided in the geographical information system (GIS environment, using fuzzy data-driven and knowledge-driven methods. To obtain the final karstic water potential model, the prepared maps were combined using fuzzy ‘AND’ operator. In the local scale, geoelectrical surveys were conducted in the recognized high potential zones. Consequently, the results of geological investigations, analysis of lineaments extracted from satellite imagery and geoelectrical resistivity data modeling and interpretation were integrated to decide on the position of high yield extraction wells. As a result, karstic water zones in the study area were identified, and based on that, two suitable drilling locations to access and extract karstic groundwater in the study area have been suggested.

  7. Spectroscopic evaluation of the environmental impact on black crusted modern mortars in urban-industrial areas.

    Science.gov (United States)

    Prieto-Taboada, N; Maguregui, M; Martinez-Arkarazo, I; Olazabal, M A; Arana, G; Madariaga, J M

    2011-03-01

    A multianalytical characterisation of black crusted modern construction materials from buildings located in the Bilbao Metropolitan area (North Spain) was carried out. According to the mineral composition determined by Raman spectroscopy, calcite and hematite were the major compounds found while aragonite, limonite, rutile, quartz and some aluminosilicates such as obsidian or amazonite (KAlSi(3)O(8)) were also present in minor percentages. As deterioration products, gypsum and anhydrite were widely found not only in the surface but also in the inner part of strongly deteriorated samples. Coquimbite (Fe(2)(SO(4))(3)·9H(2)O) was identified as well in the most protected facade where high amounts of Fe, having probably an anthropogenic origin, were measured by micro X-ray fluorescence (μ-XRF). Zn was found to be in high amounts while Cu, Pb, Ti, Mn, Sr and K were identified as minor elements. Considering the non-expected concentrations found for some anthropogenic elements, a sequential extraction was carried out in order to determine their chemical form by means of ion chromatography and inductively coupled plasma mass spectrometry. The orientation of the facades, which had a different influence from rain washing and industrial and traffic impact, was shown to affect the accumulation of different compounds in the black crust. Finally, the MEDUSA software was used to simulate the reactions among the original compounds, deposited pollutants and the atmospheric acid gases in order to explain the presence of the decaying species found.

  8. Study of the luminescence properties of a natural amazonite

    Energy Technology Data Exchange (ETDEWEB)

    Correcher, V., E-mail: v.correcher@ciemat.es [CIEMAT, Av. Complutense 22, Madrid 28040 (Spain); Garcia-Guinea, J. [Museo Nacional de Ciencias Naturales, CSIC, C/Jose Gutierrez Abascal 2, Madrid 28006 (Spain)

    2011-09-15

    Most gemstones, being natural materials (silicates, carbonates, phosphates, etc.), exhibit luminescence emission. This property could be potentially employed for personal dosimetry in the case of radiation accident or radiological terrorism where conventional monitoring has not been established. We, herein, report on the thermoluminescence (TL), radioluminescence (RL) and infra-red stimulated luminescence (IRSL) response of a well-characterised natural amazonite (KAlSi{sub 3}O{sub 8}) that, due to its bright blue-green colour when polished, is used as a gemstone. The luminescence emission wavelengths, intensities and thermal kinetics of the amazonite luminescence curves reveal that the ultraviolet band measured on amazonite aliquots is similar to other common K-rich feldspars. On this basis, one can conclude (i) association between twinning and the UV-blue TL emission can be related to structural defects located in the twin-domain boundaries where ionic alkali-self-diffusion, irreversible water losses and irreversible dehydroxylation processes can be involved. (ii) Amazonite exhibits a complex structure with several planar defects (twinning and exsolution interphases which can hold hydroxyl groups, water molecules, etc.) and point defects (impurities, Na, Pb, Mn, etc.) that can act as luminescence centres, and in fact, green and red emissions are respectively associated with the presence of Mn and Fe impurities. Finally, (iv) the thermal stability tests performed on the TL emission of the amazonite confirm a continuum in the trap distribution, i.e. progressive changes in the glow curve shape, intensity and temperature position of the maximum peak.

  9. Clinical and molecular analysis of human reproductive disorders in Brazilian patients

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    A.C. Latronico

    2004-01-01

    Full Text Available Several genes that influence the development and function of the hypothalamic-pituitary-gonadal-axis (HPG have been identified. These genes encode an array of transcription factors, matrix proteins, hormones, receptors, and enzymes that are expressed at multiple levels of the HPG. We report the experience of a single Endocrinology Unit in the identification and characterization of naturally occurring mutations in families affected by HPG disorders, including forms of precocious puberty, hypogonadism and abnormal sexual development due to impaired gonadotropin function. Eight distinct genes implicated in HPG function were studied: KAL, SF1, DAX1, GnRH, GnRHR, FSHß, FSHR, and LHR. Most mutations identified in our cohort are described for the first time in literature. New mutations in SF1, DAX1 and GnRHR genes were identified in three Brazilian patients with hypogonadism. Eight boys with luteinizing hormone- (LH independent precocious puberty due to testotoxicosis were studied, and all have their LH receptor (LHR defects elucidated. Among the identified LHR molecular defects, three were new activating mutations. In addition, these mutations were frequently associated with new clinical and hormonal aspects, contributing significantly to the knowledge of the molecular basis of reproductive disorders. In conclusion, the naturally occurring genetic mutations described in the Brazilian families studied provide important insights into the regulation of the HPG.

  10. Genetics of Isolated Hypogonadotropic Hypogonadism: Role of GnRH Receptor and Other Genes

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    Karges Beate

    2012-01-01

    Full Text Available Hypothalamic gonadotropin releasing hormone (GnRH is a key player in normal puberty and sexual development and function. Genetic causes of isolated hypogonadotropic hypogonadism (IHH have been identified during the recent years affecting the synthesis, secretion, or action of GnRH. Developmental defects of GnRH neurons and the olfactory bulb are associated with hyposmia, rarely associated with the clinical phenotypes of synkinesia, cleft palate, ear anomalies, or choanal atresia, and may be due to mutations of KAL1, FGFR1/FGF8, PROKR2/PROK2, or CHD7. Impaired GnRH secretion in normosmic patients with IHH may be caused by deficient hypothalamic GPR54/KISS1, TACR3/TAC3, and leptinR/leptin signalling or mutations within the GNRH1 gene itself. Normosmic IHH is predominantly caused by inactivating mutations in the pituitary GnRH receptor inducing GnRH resistance, while mutations of the β-subunits of LH or FSH are very rare. Inheritance of GnRH deficiency may be oligogenic, explaining variable phenotypes. Future research should identify additional genes involved in the complex network of normal and disturbed puberty and reproduction.

  11. Artvin yöresinde bazı kurakçıl karakterli türlerle yapılan ağaçlandırma çalışmasında dikim başarısının araştırılması

    OpenAIRE

    Yaşar Balaban, Işık

    2011-01-01

    Bu çalışmada, Artvin Yöresi, Hamamlı mevkiindeki bir erozyon kontrol alanına dikilen kokulu ardıç (Juniperus foetidissima), karaçam (Pinus nigra), peruka çalısı (Cotinus coggyria), fıstıkçamı (Pinus pinea), nar (Punica granatum), kızılçam (Pinus brutia) gibi kurakçıl türlerin yaşama yüzdeleri, fidanların kök boğaz çapı ve boylarına göre başarı durumu belirlenmeye çalışılmıştır. Ayrıca ince odun talaşı ve kalın odun talaşı kullanılarak yapılan malçlama işleminin etkisi araştırılmıştır. Araştır...

  12. Maysari: An Iranian Author of a Rhyme Classical Text on Pharmacy and Medicine in the Islamic Period

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    Naser Naseri

    2012-04-01

    Full Text Available Medicine is one of the sciences that have long been considered by Iranians. The history of this science in Iran before Islam is seen in books like Kalālah and Dimna in a chapter entitled as Burzuyah Tabīb and Khodāynāmeh in Sasanid era and after Islamic books on medical science is written as prose like Hidāyat ul-Muta’illimīn fi t-Tibb by Abubakr Akhavīnī Bukhārāyī and Khārazmshāhī treasure book authorship by Ismā’īl ibne Hasan Jarjānī in the late of fifth century and also books that has been developed in rhythm that one of the most important of them is Maysari's encyclopedia in fourth century (Maysari, 1994. This book contains valuable contents about four types of phlegm and tempers, types of disease and their treatment and hygiene practices and ways to keep body and soul healthy. These books as introduction has provided a field for valuable books of medical science like Ghānūn wa Nijāt written by Abu ‘Ali Sina (Avicenna. In this article, we tried briefly to introduce Maysari and features and contents of his book that is written as poem.

  13. Triple-quantum two-dimentional {sup 27}Al magic-angle spinning nuclear magnetic resonance spectroscopic study of aluminosilicate and aluminate crystals and glasses

    Energy Technology Data Exchange (ETDEWEB)

    Baltisberger, J.H. [Berea College, KY (United States); Xu, Z.; Stebbins, J.F. [Stanford Univ., CA (United States); Wang, S.H.; Pines, A. [Lawrence Berkeley National Lab., CA (United States)

    1996-07-31

    A new two-dimensional magic-angle spinning NMR experiment using multiple-quantum coherence of half-integer quadrupolar nuclei was used to study {sup 27}Al sites in crystalline samples of leucite (KAlSi{sub 2}O{sub 6}), anorthite (CaAl{sub 2}Si{sub 2}O{sub 8}), and kyanite (Al{sub 2}SiO{sub 5}), as well as CaAl{sub 2}Si{sub 2}O{sub 8} glass and a magnesium aluminoborate glass. In the crystals, multiple sites are partially resolved and new results for isotropic chemical shifts and quadrupolar parameters are derived, using data collected at a single magnetic field. Data for both leucite and anorthite are consistent with previous results that correlate chemical shifts with mean intertetrahedral bond angle. Signal can be obtained from sites with quadrupolar coupling constants as large as 9 MHz, but intensities are reduced. In the aluminoborate glass, peaks for sites with different Al coordination numbers are well seperated. The lack of such features in CaAl{sub 2}Si{sub 2}O{sub 8} glass rules out the presence of significant quantities of AlO{sub 5} and AlO{sub 6} groups. 31 refs., 8 figs., 3 tabs.

  14. PREPARATION OF HIGH THERMAL EXPANSION COEFFICIENT PORCELAINS FUSED TO METALS

    Institute of Scientific and Technical Information of China (English)

    J.P. Yang; J.Q. Wu

    2003-01-01

    Usually the thermal expansion coefficients (TEC) of metals are higher than that of porcelains. In order to match the TECs in the case of coating porcelains on metals, high TEC porcelains are needed. In this research, the high TEC phase leucite(KAlSi2 O6) in the high TEC porcelain was prepared by sol-gel method. The crystal size of leucite made by sol-gel is about 77nm through controlling the process parameters. The process from xerogel to leucite was investigated by means of DSC (differential scanning calorimetry), TG (thermogravimetry), XRD ( X-ray diffraction) and IR(infrared absorption spectrum). Leucite had been detected after the gel was treated at 900°C, this formation temperature is about 250°C lower than that of melting method.The porcelain made from 50% of the leucite powder and 50%o of low fused temperature frit has an average TEC of 19.2× 10-6/° C from room temperature to 450°C, which is much higher than the common porcelains.

  15. Test Planning, Collection and Analysis of Pressure Data Resulting from Weapon Systems.

    Science.gov (United States)

    1981-10-01

    0.20 6.66 6.65 6.16 @.IS 6.20 T 11E SEC TIlE SEC P TRACE P TRACE .5. 22.0 1k B40 6.6 _*A a. a TIM KCTi* E P TRAC P TAC 32t -- Measured Calculated...ated Figure 10(d) e=150 2.5~ 2.5 4=9O R 10 m 2.0 a- IL 09 0 .10 @.IS 0.29 0.90 0.65 9.19 6.15 6.26 TIM TRAC TIME SEC P TRACEP TRACE 2.6 2.6 R0 30 Q... VTt CA$<LL M WThC9 - A - EV’?Llŕti A󈧭TW~ALT ; HiUMANr ;o LUNiU/RAUIATICN tFFtCTS ;Ml:ThGD’S MH- - MCDJBL.v STF-,UCTUfKAL ; MCutL$, Tt-itURLTILAi

  16. Interfacial Microstructure and Mechanical Properties of Al Alloy/Mg Alloy Laminated Composite Plates Fabricated by Equal Channel Angular Processing

    Institute of Scientific and Technical Information of China (English)

    LI Guorui; ZHAO Dong; ZHAO Yaojiang; ZHOU Bin; WANG Hongxia

    2016-01-01

    KAl (7075) alloy /Mg (AZ31) alloy laminated composite plates were successfully fabricated by the equal channel angular processing (ECAP) by using route A for 1, 2, and 3 passes at 573 K, respectively. After fabrication, the 1-pass ECAPed laminated composite plates were annealed at different temperatures. The microstructure evolution, phase constituent, and bonding strength near the joining interface of Al (7075) alloy /Mg (AZ31) alloy laminated composites plates were evaluated with scanning electron microscopy, X-ray diffraction, and shear tests. The experimental results indicated that a 20 μm diffusion layer was observed at the joining interface of Al (7075) alloy /Mg (AZ31) alloy laminated composites plates fabricated by the 1-pass ECAP, which mainly included Al3Mg2 and Mg17Al12 phases. With the increase of passes, the increase of diffusion layer thickness was not obvious and the form of crack in these processes led to the decrease of bonding strength. For 1-pass ECAPed composites, the thickness of diffusion layer remained unchanged after annealed at 473 K, while the bonding strength reached its maximum value 29.12 MPa. However, after elevating heat treatment temperature to 573 K, the thickness of diffusion layer increased rapidly, and thus the bonding strength decreased.

  17. A buffered form of creatine does not promote greater changes in muscle creatine content, body composition, or training adaptations than creatine monohydrate

    Directory of Open Access Journals (Sweden)

    Jagim Andrew R

    2012-09-01

    Full Text Available Abstract Background Creatine monohydrate (CrM has been consistently reported to increase muscle creatine content and improve high-intensity exercise capacity. However, a number of different forms of creatine have been purported to be more efficacious than CrM. The purpose of this study was to determine if a buffered creatine monohydrate (KA that has been purported to promote greater creatine retention and training adaptations with fewer side effects at lower doses is more efficacious than CrM supplementation in resistance-trained individuals. Methods In a double-blind manner, 36 resistance-trained participants (20.2 ± 2 years, 181 ± 7 cm, 82.1 ± 12 kg, and 14.7 ± 5% body fat were randomly assigned to supplement their diet with CrM (Creapure® AlzChem AG, Trostberg, Germany at normal loading (4 x 5 g/d for 7-days and maintenance (5 g/d for 21-days doses; KA (Kre-Alkalyn®, All American Pharmaceutical, Billings, MT, USA at manufacturer’s recommended doses (KA-L, 1.5 g/d for 28-days; or, KA with equivalent loading (4 x 5 g/d for 7-days and maintenance (5 g/d doses of CrM (KA-H. Participants were asked to maintain their current training programs and record all workouts. Muscle biopsies from the vastus lateralis, fasting blood samples, body weight, DEXA determined body composition, and Wingate Anaerobic Capacity (WAC tests were performed at 0, 7, and 28-days while 1RM strength tests were performed at 0 and 28-days. Data were analyzed by a repeated measures multivariate analysis of variance (MANOVA and are presented as mean ± SD changes from baseline after 7 and 28-days, respectively. Results Muscle free creatine content obtained in a subgroup of 25 participants increased in all groups over time (1.4 ± 20.7 and 11.9 ± 24.0 mmol/kg DW, p = 0.03 after 7 and 28-days, respectively, with no significant differences among groups (KA-L −7.9 ± 22.3, 4.7 ± 27.0; KA-H 1.0 ± 12.8, 9.1

  18. XVIII amžiaus antrosios pusės Lietuvos Didžiosios Kunigaikštystės universalieji laikmačiai: Vilniaus ir Gardino kalendoriai. Universal Time counters of the Grand Duchy of Lithuania in the second half of the 18th century: Vilnius and Grodno Calendars

    Directory of Open Access Journals (Sweden)

    Jurgita Žąsinaitė-Gedminienė

    2010-01-01

    Full Text Available The article focuses on the calendars of the Grand Duchy of Lithuania (GDL which were published in the second half of the 18th century. Emphasizing the fact that in the Age of Enlightenment calendars as well as other periodicals underwent significant developments in terms of form, content, and audi­ence, Vilnius Calendar (pl. Kalendarz Wileński and Grodno Calendar (Kalędarz Grodzieński are being analysed.Vilnius and Grodno Calendars included news from the whole world and from the area of the GDL. The information concerning astronomy, medicine, and prophesies also used to be published there.The calendars dealt with social and moral issues of the time and were considered to be peculiar in­structors of the society. Apart from that they enabled their readers to express themselves by proclaiming openly society’s interests and needs. In this way a specific communication medium between this uni­versal form of press and its audience was created. From the publications of Vilnius and Grodno Calendars the history of Lithuanian post could be traced. There is also much information of the state management in the GDL in the last decades of the 18th century.In general Vilnius and Grodno Calendars could be regarded as some ABC books of politics, econo­my, and culture that were dedicated to the inquisitive and demanding society of the second half of the 18th century.

  19. Annual input fluxes and source identification of trace elements in atmospheric deposition in Shanxi Basin: the largest coal base in China.

    Science.gov (United States)

    Zhong, Cong; Yang, Zhongfang; Jiang, Wei; Yu, Tao; Hou, Qingye; Li, Desheng; Wang, Jianwu

    2014-11-01

    Industrialization and urbanization have led to a great deterioration of air quality and provoked some serious environmental concerns. One hundred and five samples of atmospheric deposition were analyzed for their concentrations of 13 trace elements (As, Cd, Cu, Fe, Al, Co, Cr, Hg, Mn, Mo, Pb, Se, and Zn) in Shanxi Basin, which includes six isolate basins. The input fluxes of the trace elements in atmospheric deposition were observed and evaluated. Geostatistical analysis (EF, PCA, and CA ) were conducted to determine the spatial distribution, possible sources, and enrichment degrees of trace elements in atmospheric deposition. Fe/Al and K/Al also contribute to identify the sources of atmospheric deposition. The distribution of trace elements in atmospheric deposition was proved to be geographically restricted. The results show that As, Cd, Pb, Zn, and Se mainly come from coal combustion. Fe, Cu, Mn, Hg, and Co originate mainly from interactions between local polluted soils and blowing dust from other places, while the main source of Al, Cr, and Mo are the soil parent materials without pollution. This work provides baseline information to develop policies to control and reduce trace elements, especially toxic elements, from atmospheric deposition. Some exploratory analytical methods applied in this work are also worth considering in similar researches.

  20. Phenotypic variability in X-linked ocular albinism: Relationship to linkage genotypes

    Energy Technology Data Exchange (ETDEWEB)

    Schnur, R.E. [Children`s Hospital of Philadelphia, PA (United States)]|[Univ. of Pennsylvania School of Medicine, Philadelphia, PA (United States); Wick, P.A. [Children`s Hospital of Philadelphia, PA (United States); Bailey, C. [Univ. of Pennsylvania School of Medicine, Philadelphia, PA (United States); Rebbeck, T. [Fox Chase Cancer Center, Philadelphia, PA (United States); Weleber, R.G. [Oregon Health Sciences Univ., Portland, OR (United States); Wagstaff, J. [Boston Children`s Hospital, MA (United States); Grix, A.W. [Univ. of California, Davis, CA (United States); Pagon, R.A. [Children`s Hospital and Medical Center, Seattle, WA (United States); Hockey, A. [Princess Margaret Hospital, Perth (Australia); Edwards, M.J. [Newcastle Western Suburbs Hospital, Waratah (Australia)

    1994-09-01

    One hundred nineteen individuals from 11 families with X-linked ocular albinism (OA1) were studied with respect to both their clinical phenotypes and their linkage genotypes. In a four-generation Australian family, two affected males and an obligatory carrier lacked cutaneous melanin macroglobules (MMGs); ocular features were identical to those of Nettleship-Falls OA1. Four other families had more unusual phenotypic features in addition to OA1. All OA1 families were genotyped at DXS16, DXS85, DXS143, STS, and DXS452 and for a CA-repeat polymorphism at the Kallmann syndrome locus (KAL). Separate two-point linkage analyses were performed for the following: group A, six families with biopsy-proved MMGs in at least one affected male; group B, four families whose biopsy status was not known; and group C, OA-9 only (16 samples), the family without MMGs. At the set of loci closest to OA1, there is no clear evidence in our data set for locus heterogeneity between groups A and C or among the four other families with complex phenotypes. Combined multipoint analysis (LINKMAP) in the 11 families and analysis of individual recombination events confirms that the major locus for OA1 resides within the DXS85-DXS143 interval. The authors suggest that more detailed clinical evaluations of OA1 individuals and families should be performed for future correlation with specific mutations in candidate OA1 genes. 29 refs., 5 figs., 4 tabs.

  1. A course in mathematical physics 2 classical field theory

    CERN Document Server

    Thirring, Walter

    1978-01-01

    In the past decade the language and methods ofmodern differential geometry have been increasingly used in theoretical physics. What seemed extravagant when this book first appeared 12 years ago, as lecture notes, is now a commonplace. This fact has strengthened my belief that today students of theoretical physics have to learn that language-and the sooner the better. Afterall, they willbe the professors ofthe twenty-first century and it would be absurd if they were to teach then the mathematics of the nineteenth century. Thus for this new edition I did not change the mathematical language. Apart from correcting some mistakes I have only added a section on gauge theories. In the last decade it has become evident that these theories describe fundamental interactions, and on the classical level their structure is suffi­ cientlyclear to qualify them for the minimum amount ofknowledge required by a theoretician. It is with much regret that I had to refrain from in­ corporating the interesting developments in Kal...

  2. AMALGAM ve KOMPOZİT REZİN RESTORASYONLARIN AĞIZDA KALMA SÜRELERİ ve YENİLENME NEDENLERİNİN KLİNİK OLARAK DEĞERLENDİRİLMESİ-CLINICAL EVALUATION OF LONGEVITY OF AMALGAM AND COMPOSITE RESIN RESTORATIONS AND REASONS FOR THEIR REPLACEMENTS

    OpenAIRE

    Tiritoğlu, Meserret; Alpaslan, Gönül

    2013-01-01

    ÖZETBu çalışmada, Hacettepe Üniversitesi Diş Hekimliği Fakültesi tedavi Kliniğine başvuran ve dönem IV, dönem V öğrencileri tarafından tedavi edilen hastalara yapılan uygulamaların, ne kadarının ilk kez yapılan, ne kadarının yenilenen restorasyonlar olduğu ve yenilenme nedenleri ile birlikte bu restorasyonların ağızda kalış süreleri, ayrıca son yıllarda amalgam konusunda basında yer alan olumsuz haberlerin yenileme oranlarını ne yönde etkilediği klinik olarak araştırıldı.Bir aylık süre sonund...

  3. Stages of development in Arabic philosophical nomenclature: Emergence, progression and stability

    Directory of Open Access Journals (Sweden)

    Tigani M. A. Zaid

    2016-12-01

    Full Text Available The study of the creation of a technical language within an existing natural language reveals to us both the internal and external dynamics of this complex phenomenon. The history of Arabic lexical definitions of different disciplines in the historical Islamic civilization provides us with a wealth of information on how these processes take place at each level of development. In this article while we will be highlighting on the history of Arabic intellectual lexical definitions we will focus on the development of the disciplines that constitute the Arabic philosophical technical languages i.e. Kalām and falsafah. In each discipline we closely followed the three conventional phases of development i.e. emergence, progression and stability. It should be remarked that though there are distinctive features of each phase, yet there are equally overlaps among these phases. This study brought to our attention the significant place of al-Taʿrifat of al-Jurjānī as the most sophisticated dictionary of sciences in the historical Islamic civilization.

  4. Stability region of K0.2Na0.8AlSi3O8 hollandite at 22 GPa and 2273 K

    Science.gov (United States)

    Zhou, Youmo; Irifune, Tetsuo; Ohfuji, Hiroaki; Shinmei, Toru; Du, Wei

    2017-01-01

    Lingunite (hollandite with Na contents of 80-85 mol%) discovered in the shock veins of strongly shocked meteorites is an important signature of shock metamorphism. To seek the stability region of lingunite, phase relations in the system KAlSi3O8-NaAlSi3O8 have been investigated by multi-anvil experiments at pressures of 20-23 GPa and temperatures of 1873 and 2273 K. Phase assemblages of hollandite + jadeite + stishovite, hollandite + calcium ferrite-type NaAlSiO4 + stishovite and hollandite single phase have been recovered, depending on the pressure-temperature conditions and the compositions of starting materials. Both pressure and temperature have large effects on the solubility of Na in hollandite, and hollandite with 79 mol% Na, similar to the natural lingunite in terms of Na content, has been firstly synthesized at 22 GPa and 2273 K. The stability region of K0.2Na0.8AlSi3O8 hollandite is comparable to the typical pressure-temperature conditions of the shock veins of strongly shocked meteorites (20-25 GPa and 2273-2500 K).

  5. Novel FGFR1 and KISS1R Mutations in Chinese Kallmann Syndrome Males with Cleft Lip/Palate

    Directory of Open Access Journals (Sweden)

    Hao Xu

    2015-01-01

    Full Text Available Kallmann syndrome (KS is characterized by isolated hypogonadotropic hypogonadism (IHH with anosmia and is sometimes associated with cleft lip/palate (CLP. In order to describe the clinical features, genetic etiology, and treatment outcome of KS males with CLP, we performed genetic screening for 15 known causal IHH genes (KAL1, FGFR1, NELF, FGF8, CHD7, WDR11, SEMA3A, KISS1R, KISS1, PROKR2, PROK2, TAC3, TACR3, GNRH1, and GNRHR in four KS with CLP patients and six IHH patients without CLP. Two novel heterozygous missense mutations in FGFR1, (NM_001174066: c.776G>A (p.G259E and (NM_001174066: c.358C>T (p.R120C, were identified in a 23-year-old KS male with cleft lip and an 18-year-old KS patient with cleft lip and palate, dental agenesis, and high arched palate, respectively. These two mutations were not presented in their healthy parents and 200 normal controls. One novel heterozygous missense mutation in KISS1R, (NM_032551: c.587C>A (p.P196H, was identified in an 18-year-old KS male with cleft lip and dental agenesis who developed sperm after being treated with gonadotropin. This mutation was also presented in his healthy father and grandfather. These results have implications for the diagnosis, genetic counseling, and treatment of KS and CLP males with mutations in FGFR1 gene.

  6. Cultural meanings of musculoskeletal diseases in Chile's Mapuche Population.

    Science.gov (United States)

    Alarcon, Ana M; Vidal, Aldo; Castro, Marcela

    2013-10-01

    Eight out of 10 Mapuche indigenous women have a musculoskeletal disorder (MSD) and do not seek early medical aid. To study both the cultural meanings and implications of MSD from the Mapuche worldview. Ethnographic study carried out from 2008 to 2011 on indigenous reserves in southern Chile. Sixty-four Mapuches participated in comprehensive interviews, which were transcribed and analyzed by the research team. Five cultural domains: (a) foro kutran/bone disease is the general denomination of MSD; (b) Re-Rume Kutran/progressive and incurable course, refers to the course of the disease; (c) Kalül fücha mawiza/body is an old tree, describes internal manifestations such as worn bones, dry body, weak blood, and spiritual weakness; (d) witrür tripai foro/deformation is the external manifestation of MSD; and (e) Reñma ka lof kutran/family and community suffering refers to the impact of MSD. The explanation of MSD is consistent with the integrated body-nature-spirit worldview of the Mapuche. To provide cultural nursing health care so that patients receive prompt diagnosis and care.

  7. Manufacturing Microporous Foam Zinc Materials with High Porosity By Electrodeposition

    Institute of Scientific and Technical Information of China (English)

    TIAN QinGhua; GUO Xueyi

    2011-01-01

    In order to get foam zinc materials of porous metal electrode,a novel method for preparing foam zinc was proposed,in which the polyurethane foam with diameter of 0.3 mm as substrate was processed by degreasing,roughening,activating,electroless plating and electrodeposition.The main factors affecting the process,such as ZnSO4 content,temperature,pH value,current density,and electrodes distance,were investigated comprehensively.The optimal process conditions are 250 g/L ZnSO4,20 g/L Al2(SO4)3,40 g/L KAl(SO4)2,30 g/L Na2SO4,pH=3.5,4.0 cm of electrodes distance and 0.04 A/cm2 current density at 30 ℃.The result shows that adding ultrasonic on the process can elevate the deepening plating ability and current efficiency.Foam zinc material with a high porosity of 92.2% and a three-dimensional network structure can be fabricated by electrodeposition.

  8. Authigenetic K—feldspars and Their Relations to Sn—polymetallic Mineralization in the Dachang Ore Field

    Institute of Scientific and Technical Information of China (English)

    潘家华; G.C.AMSTUTZ

    1993-01-01

    Sn-polymetallic ores at Dachang,Guangxi Autonomous Region,China,are hosted in Middle-Upper Devonian reef limestones,siliceous rocks,banded and lenticular limestones,etc.Two types of orebodies can be distinguished according to their telations to the bedding:one is distributed along the bedding and the.other cuts across the bedding.Sn and sulfide orebodies associated with K-feldspare are mostly characterized by laminated ore structure. Microscopic examinations of K-feldspar-bearing rocks,in conjunction with X-ray diffraction,chemical composiion and cathodoluminescence data for K-feldspars,as well as their telations to mineralization,the authors consider that the K-feldspare are of authigenic origin,subordinate to the epigenetic stage of diagenesis,They resulted from the reaction of mixed,deep-seated,circulating underground hot waters rich in K,Al and Si with argillaceous carbonates during the Indo nesian orogenic movement.It is suggested more attention should be paid to the effect of authigenic K-feldspars on Sn mineralization.In the meantime the event related to circulating underground hot waters should also be taken into account so as to provide new clues to blind ore prospecting.

  9. DEPRElVl KlJVVı

    Directory of Open Access Journals (Sweden)

    Hüseyin KASAP

    2003-08-01

    Full Text Available B u ç a l ış nıada , dep rem yükleri al t ı ndaki 4,6, 8 ve 10 katlı perdeli-çerçeveli 3 ayrı tip binanınperde e nkesi t değişinlinin sisteınin kesıne kuvYetidağ ı lı ını na etkisi incelenntiştir.Döşeme kalı n lı ğ ı, döşeme ağırlığı, kiriş a ğ ı r l ığı ,perde a ğırlığ ı duvar a ğır lı ğı ve bunlara b ağlıolarak kolon boyutu ta yi n e dil ıni ş ti r .Kolonboyutlarına bağlı olarak kat ağıı4hkları t ay inedilnıiştir.Hesaplanan kat a ğ ır lı kl a rı ile ta b ankesme kuv,

  10. PFAPA sendromu Çağrılı Editör

    OpenAIRE

    Kasapçopur, Özgür; Arısoy, Nil

    2009-01-01

    PFAPA sendromu çocukluk çağında yineleyen ateş aftöz stomatit farenjit ve servikal adenitle ortaya çıkan bir otoenflamatuar hastalıktır Hastalık çoğunlukla beş yaşın altında ortaya çıkar Hastalığa ait ateş atakları düzensiz aralıklarla yineler ve ortalama 3 4 sürüp kendiliğinden düzelir Ateş çocuklarda genellikle 39 derecenin üzerindedir ve tüm antibiyotik ve ateş düşürücü tedavilere yanıtsızdır Hastalardaki klinik bulguların tümü tek doz kortikosteroid uygulaması ile hemen kaybolur Kalıcı te...

  11. The human interactome knowledge base (hint-kb): An integrative human protein interaction database enriched with predicted protein–protein interaction scores using a novel hybrid technique

    KAUST Repository

    Theofilatos, Konstantinos A.

    2013-07-12

    Proteins are the functional components of many cellular processes and the identification of their physical protein–protein interactions (PPIs) is an area of mature academic research. Various databases have been developed containing information about experimentally and computationally detected human PPIs as well as their corresponding annotation data. However, these databases contain many false positive interactions, are partial and only a few of them incorporate data from various sources. To overcome these limitations, we have developed HINT-KB (http://biotools.ceid.upatras.gr/hint-kb/), a knowledge base that integrates data from various sources, provides a user-friendly interface for their retrieval, cal-culatesasetoffeaturesofinterest and computesaconfidence score for every candidate protein interaction. This confidence score is essential for filtering the false positive interactions which are present in existing databases, predicting new protein interactions and measuring the frequency of each true protein interaction. For this reason, a novel machine learning hybrid methodology, called (Evolutionary Kalman Mathematical Modelling—EvoKalMaModel), was used to achieve an accurate and interpretable scoring methodology. The experimental results indicated that the proposed scoring scheme outperforms existing computational methods for the prediction of PPIs.

  12. Investigation of the Lipophilicity of 2-Benzoylpyridine-Thiosemicarbazone Based on the Ion Transfer across the Liquid/Liquid Interface%液/液界面电子转移研究苯甲酰吡啶-缩氨基硫脲的亲脂性

    Institute of Scientific and Technical Information of China (English)

    AKGEMCI Emine G.; BINGOL Haluk; OZCELIK Mehmet; ERSOZ Mustafa

    2008-01-01

    The ion transfer reaction of 2-benzoylpyridine-thiosemicarbazone (HL), which has antimicrobial and antifungal properties and anticancer activity, has been studied to determine its lipophilicity by cyclic voltammetry at the water/1,2-dichloroethane (1,2-DCE) interface. The physicochemical parameters such as standard partition coefficient (IgP1) and the standard Gibbs energy of transfer (△G0,w→otr,I) of the protonated form of the ligand were measured as a function of pH in aqueous phase. The protonated form of the ligand exhibited reversible or quasi-reversible voltammograms at the 1,2-DCE in the range of pH 1-5. The protonation constants of the ligand, pKal, and pK? were determined spectrophotometrically and were found to be 12.14 and 3.24, respectively. The standard Gibbs energy of transfer (△G0,w→otr,N) and the partition coefficient of neutral species (IgPN) were also determined by the shake-flask method. The standard Gibbs energy of transfer of this compound across the water/1,2-DCE interface was evaluated as the quantitative measure of its lipophilicity. The difference between lgP1 and lgPN was related to the degree of charge delocalization and was used to evaluate qualitatively the lipophilicity of the ligand.

  13. AHMET RIZA’NIN SOSYOLOJİK VE DİNİ GÖRÜŞLERİ

    OpenAIRE

    SARI, Süleyman Arif

    2004-01-01

    Bu tez giriş ve üç bölümden oluşmaktadır. Türkiye’de Pozitivizm akımının öncüsü durumunda olan Ahmet Rıza Bey, ülkeye pozitivist zihniyetin girmesini isterken, dinin sosyal içerikli konularına getirdiği değişik yorumlar ile Türk aydınlarının düşünce ufkunda ve sisteminde farklı bir yol açmıştır. Açtığı bu yol, bazı düşünce kalıpları içerisinde günümüzde de etkisini sürdürmektedir. Giriş bölümünde tezin konusu, amacı, önemi ve yöntemi ortaya konmuştur. Birinci bölümde din sosy...

  14. DO STRUCTURES OF IDIOMS CHANGE? DEYİMLERİN YAPISI DEĞİŞİR Mİ?

    Directory of Open Access Journals (Sweden)

    Ahmet Turan SİNAN

    2009-12-01

    Full Text Available Idioms that have an important place in a language exist as ready word patterns. It has always been emphasized that Turkey Turkish has plentiful idioms. It can even be said that colorful side of idiom structures has directed many researchers to this field. Idiom structures can change and sometimes they can disappear by losing their liveliness in parallel with the change and development of society. We see this talented word combination in the language structure showing each concept’s indications. Short structures, idioms, are also the sings of human’s tendency to convert the meaning in shortcut way. The signs which come together and form idiom as a result of creativeness of language are idioms gain meaning as a whole. Vocabularies are structured with or without affixes. The situation special to word-combinations emerges. The factors constructing the idioms can not be changed due to this structure. However, word changes at the beginning and in the middle of some idioms can be seen. Even if idioms are structured, it is seen that they replace with another word related in meaning sometimes at the beginning of the words, in the middle or at the end. It is also seen that, in idioms ending with infinitive, the words except verbs can change. Bir dilin söz varlığı içinde önemli bir yer işgal deyimler, hazır söz kalıpları olarak bulunurlar. Türkiye Türkçesinin çok zengin bir deyim varlığına sahip olması hep vurgulanır olmuştur. Hatta deyim yapılarının renkli yüzü de birçok araştırmacıyı bu alana yöneltmiştir denebilir. Toplum hayatının değişip gelişmesiyle koşut deyim yapıları da değişebilir, bazen de canlılığını kaybederek ortadan kaybolabilirler. Her kavramın göstergesini yapmak isteyen dilin yapısı içinde bu yetenekli söz birleşmelerini görüyoruz. Kısa yapılar olan deyimler insanın, en az kelime ile anlamı iletme eğiliminin işaretleridir aynı zamanda. Dilin yaratıcılık

  15. PEMANFAATAN BIOMASSA LIMBAH JAMUR TIRAM SEBAGAI BAHAN BAKAR ALTERNATIF UNTUK PROSES STERILISASI JAMUR TIRAM

    Directory of Open Access Journals (Sweden)

    Untung Surya Dharma

    2013-12-01

    Full Text Available Biomassa adalah suatu limbah benda padat yang bisa dimanfaatkan lagi sebagai sumber bahan bakar. Energi biomassa dapat menjadi sumber energi alternatif pengganti bahan bakar fosil (minyak bumi karena beberapa sifatnya yang menguntungkan yaitu sumber energi ini dapat dimanfaatkan secara lestari karena sifatnya yang dapat diperbaharui (renewable resources, sumber energi ini relatif tidak mengandung unsur sulfur sehingga tidak menyebabkan polusi udara dan juga dapat meningkatkan efisiensi pemanfaatan sumber daya hutan dan pertanian. Salah satu biomassa yang sekarang belum termanfaatkan dengan baik adalah limbah jamur. Jenis jamur di Indonesia banyak macamnya contohnya: jamur tiram, jamur merang, jamur kuping dan lain-lain. Sementara ini masih banyak limbah jamur tiram hanya untuk pupuk tanaman bahkan banyak yang hanya di buang begitu saja, padahal dalam proses produksi jamur tiram yaitu sterilisasi baglog (bahan baku jamur dengan cara pengukusannya di atas tungku api selama 8 jam, masyarakat masih menggunakan LPG atau kayu bakar untuk mengukus baglog tersebut yang membutuhkan biaya lebih. Penelitian ini bertujuan membantu masyarakat dalam pengolahan limbah jamur tiram untuk Proses Pembuatan Briket Limbah Jamur Tiram Sebagai Bahan Bakar Alternatif, pembuatan briket ini menggunakan bahan perekat tepung kanji dengan perbandingan 3:1, ukuran partikel 40 mesh (0,250mm , bentuk beriket silinder pejal. Hasil pengujian proksimasi menunjukkan bahwa kandungan kadar air 1,57 %, Kadar abu 28,53 %, nilai kalor 3306 kal/gram, kadar karbon 51,22 %, nilai rata-rata efisiesi pembakaran 60,88% . Berdasarkan uji pembakaran, briket limbah jamur tiram dapat digunakan sebagai bahan bakar.

  16. Louis Massignon l'amour mystique ou l'extase dans l'abandon

    Directory of Open Access Journals (Sweden)

    Jacques Keryell

    2008-09-01

    Full Text Available Parler de Massignon et de son Amour de Dieu n'est pas chose aisée. En effet, si les mystiques musulmans des premiers siècles de l'hégire ont été les hérauts de cet Amour : Al-Hallâj, Râbia al-Adawiyya, Al-Niffâri, Ibn Arabi, Ansâri, Al-Ghazâli, l'Amour de Dieu comme tel, n'est pas au cœur du "ilm al kalâm", de la théologie musulmane traditionnelle. Pour Massignon, langue et spiritualité étaient intimement liées. Si je devais me placer dans une perspective musulmane, je dirais que Louis Massignon se situe dans la ligne de la "wahdat al shuhûd", celle de "l'unicité du témoignage" ou Dieu se témoigne Lui-même en son mystère dans le cœur du soufi.

  17. Geochemical modeling of leaching from MSVI air-pollution-control residues

    DEFF Research Database (Denmark)

    Astrup, Thomas; Dijkstra, J.J.; Comans, R.N.J.

    2006-01-01

    This paper provides an improved understanding of the leaching behavior of waste incineration air-pollution-control (APC) residues in a long-term perspective. Leaching was investigated by a series of batch experiments reflecting leaching conditions after initial washout of highly soluble salts from...... residues. Leaching experiments were performed at a range of pH-values using carbonated and noncarbonated versions of two APC residues. The leaching data were evaluated by geochemical speciation modeling and discussed with respect to possible solubility control. The leaching of major elements as well...... of Al, Ba, Ca, Cr, Pb, S, Si, V, and Zn was found influenced by solubility control from Al2O3, Al(OH)3, Ba(S,Cr)O4 solid solutions, BaSO4, Ca6Al2(SO4)3(OH)12â26H2O, CaAl2Si4O12â2H2O, Ca-(OH)2, CaSiO3, CaSO4â2H2O, CaZn2(OH)6â2H2O, KAlSi2O6, PbCO3, PbCrO4, Pb2O3, Pb2V2O7, Pb3(VO4)2, ZnO, Zn2SiO4, and Zn...

  18. Alkali elemental and potassium isotopic compositions of Semarkona chondrules

    Science.gov (United States)

    Alexander, C.M. O'D.; Grossman, J.N.

    2005-01-01

    We report measurements of K isotope ratios in 28 Semarkona chondrules with a wide range of petrologic types and bulk compositions as well as the compositions of CPX-mesostasis pairs in 17 type I Semarkona chondrules, including two chondrules with radial alkali zonation and 19 type II chondrules. Despite the wide range in K/Al ratios, no systematic variations in K isotopic compositions were found. Semarkona chondrules do not record a simple history of Rayleigh-type loss of K. Experimentally determined evaporation rates suggest that considerable alkali evaporation would have occurred during chondrule formation. Nevertheless, based on Na CPX-mesostasis distribution coefficients, the alkali contents of the cores of most chondrules in Semarkona were probably established at the time of final crystallization. However, Na CPX-mesostasis distribution coefficients also show that alkali zonation in type I Semarkona chondrules was produced by entry of alkalis after solidification, probably during parent body alteration. This alkali metasomatism may have gone to completion in some chondrules. Our preferred explanation for the lack of systematic isotopic enrichments, even in alkali depleted type I chondrule cores, is that they exchanged with the ambient gas as they cooled. ?? The Meteoritical Society, 2005.

  19. Characterization of the Late Barremian in north central Tunisia: Is it a prelude to the oceanic anoxic event 1a?

    Science.gov (United States)

    Khaled, Houda; Chaabani, Fredj; Boulvain, Frederic; Mansoura, Mouez

    2017-01-01

    The Late Barremian-Early Aptian of the Jebel Serdj was studied in detail regarding to lithology, microfacies, mineralogy and geochemistry in order to reconstruct the paleoenvironmental change of the Pre-Selli Event. The studied section is about 37 m-thick and it is consisting of limestone and marlstone interbeds spanning the latest Barremian-Early Aptian. During the latest Barremian, kaolinite/illite intensity ratios show high values possibly indicating a warming trend followed then by decreasing values that may indicate a cooling trend. During the Early Aptian, this cooling trend is reverted into humid/warming trend during the Selli event. During the Late Barremian, the low abundance of Ti/Al and K/Al ratios and the enrichment of some elements such as Ba, Cu and Ni suggests that the studied section is characterized by a high productivity, and a minimal detrital inputs. During the Late Barremian, the δ13C increases sporadically and is associated with enrichments in some redox-sensitive indices U/Th, V/V + Ni, Ni/Co and V/Cr indicating the presence of intermittent dysoxic to anoxic conditions.

  20. Sorption mechanisms of cephapirin, a veterinary antibiotic, onto quartz and feldspar minerals as detected by Raman spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Peterson, Jonathan W., E-mail: peterson@hope.ed [Department of Geological and Environmental Sciences, Hope College, P.O. Box 9000, Holland, MI 49422-9000 (United States); O' Meara, Theresa A. [Department of Geological and Environmental Sciences, Hope College, P.O. Box 9000, Holland, MI 49422-9000 (United States); Seymour, Michael D. [Department of Chemistry, Hope College, P.O. Box 9000, Holland, MI 49422-9000 (United States); Wang Wei; Gu Baohua [Environmental Sciences Division, Oak Ridge National Laboratory, P.O. Box 2008, Oak Ridge, TN 37831 (United States)

    2009-06-15

    Raman spectroscopy was used to investigate sorption mechanisms of cephapirin (CHP), a veterinary antibiotic, onto quartz (SiO{sub 2}) and feldspar (KAlSi{sub 3}O{sub 8}) at different pH. Sorption occurs by electrostatic attraction, monodentate and bidentate complexation. The zwitterion (CHP{sup o}) adsorbs to a quartz{sup (+)} surface by electrostatic attraction of the carboxylate anion group (-COO{sup -}) at low pH, but adsorbs to a quartz{sup (-)} surface through electrostatic attraction of the pyridinium cation, and possibly COO{sup -} bridge complexes, at higher pH. CHP{sup -} bonds to quartz{sup (-)} surfaces by bidentate complexation between one oxygen of -COO{sup -} and oxygen from carbonyl of an acetoxymethyl group. On a feldspar{sup (+/-)} surface, CHP{sup o} forms monodentate complexes between C=O, and possible -COO{sup -} bridges and/or electrostatic attachments to localized edge (hydr)oxy-Al surfaces. CHP{sup -} adsorbs to feldspar{sup (-)} through monodentate C=O complexation. Similar mechanisms may operate for other cephalosporins. Results demonstrate, for the first time, that Raman techniques can be effective for evaluating sorption mechanisms of antibiotics. - Raman spectroscopy indicates that cephapirin, a veterinary antibiotic, sorbs to quartz and feldspar by electrostatic attraction, and monodentate and bidentate complexation.